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7ELM
Structure of Csy-AcrIF24
ARTICLE Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24 Lingguang Yang 1,2,6, Laixing Zhang 3,6, Peipei Yin1,2,6, Hao Ding1,6, Yu Xiao3, Jianwei Zeng 3, Wenhe Wang3, Huan Zhou4, Qisheng Wang4, Yi Zhang 1, Zeliang Chen1,5, Maojun Yang3 & Yue Feng 1✉ CRISPR-Cas ...
7ELN
Structure of Csy-AcrIF24-dsDNA
ARTICLE Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24 Lingguang Yang 1,2,6, Laixing Zhang 3,6, Peipei Yin1,2,6, Hao Ding1,6, Yu Xiao3, Jianwei Zeng 3, Wenhe Wang3, Huan Zhou4, Qisheng Wang4, Yi Zhang 1, Zeliang Chen1,5, Maojun Yang3 & Yue Feng 1✉ CRISPR-Cas ...
7ELP
Crystal structure of xanthine riboswitch with xanthine, iridium hexammine soak
Published online 14 June 2021 Nucleic Acids Research, 2021, Vol. 49, No. 12 7139–7153 https://doi.org/10.1093/nar/gkab486 Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition Xiaochen Xu1,†, Michaela Egger2,†, Hao Chen1,†, Karolina Bartosik2, Ronald Micura2,* and Aiming Ren1,* 1Life Sci...
7ELQ
Crystal structure of xanthine riboswitch with xanthine, manganese saok
Published online 14 June 2021 Nucleic Acids Research, 2021, Vol. 49, No. 12 7139–7153 https://doi.org/10.1093/nar/gkab486 Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition Xiaochen Xu1,†, Michaela Egger2,†, Hao Chen1,†, Karolina Bartosik2, Ronald Micura2,* and Aiming Ren1,* 1Life Sci...
7ELR
Crystal structure of xanthine riboswitch with xanthine
Published online 14 June 2021 Nucleic Acids Research, 2021, Vol. 49, No. 12 7139–7153 https://doi.org/10.1093/nar/gkab486 Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition Xiaochen Xu1,†, Michaela Egger2,†, Hao Chen1,†, Karolina Bartosik2, Ronald Micura2,* and Aiming Ren1,* 1Life Sci...
7ELS
Crystal structure of xanthine riboswitch with 8-azaxanthine
Published online 14 June 2021 Nucleic Acids Research, 2021, Vol. 49, No. 12 7139–7153 https://doi.org/10.1093/nar/gkab486 Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition Xiaochen Xu1,†, Michaela Egger2,†, Hao Chen1,†, Karolina Bartosik2, Ronald Micura2,* and Aiming Ren1,* 1Life Sci...
7ELY
A peptide with high affinity for B-Cell lymphoma2(Bcl-2)
An evolution-inspired strategy to design disulfide- rich peptides tolerant to extensive sequence manipulation† Jun Zha,ab Jinjing Li,a Shihui Fan,a Zengping Duan,a Yibing Zhaoa and Chuanliu Wu *a Natural disulfide-rich peptides (DRPs) are valuable scaffolds for the development of new bioactive molecules and therapeutics. ...
7EM1
Crystal structure of the PI5P4Kbeta-ITP complex
The GTP-responsiveness of PI5P4Kβ is evolved by a compromised trade-off between activity and specificity Koh Takeuchi1,2,17,*,#, Yoshiki Ikeda3,13,#, Miki Senda4,#, Ayaka Harada4,15, Koji Okuwaki5, Kaori Fukuzawa6, So Nakagawa7, Hong Yang Yu3,4, Lisa Nagase4, Misaki Imai1,2, Mika Sasaki3, Yu-Hua Lo4,14, Doshun Ito4,...
7EM2
Crystal structure of the PI5P4Kbeta-XTP complex
The GTP-responsiveness of PI5P4Kβ is evolved by a compromised trade-off between activity and specificity Koh Takeuchi1,2,17,*,#, Yoshiki Ikeda3,13,#, Miki Senda4,#, Ayaka Harada4,15, Koji Okuwaki5, Kaori Fukuzawa6, So Nakagawa7, Hong Yang Yu3,4, Lisa Nagase4, Misaki Imai1,2, Mika Sasaki3, Yu-Hua Lo4,14, Doshun Ito4,...
7EM3
Crystal structure of the PI5P4Kbeta-2a-ATP complex
The GTP-responsiveness of PI5P4Kβ is evolved by a compromised trade-off between activity and specificity Koh Takeuchi1,2,17,*,#, Yoshiki Ikeda3,13,#, Miki Senda4,#, Ayaka Harada4,15, Koji Okuwaki5, Kaori Fukuzawa6, So Nakagawa7, Hong Yang Yu3,4, Lisa Nagase4, Misaki Imai1,2, Mika Sasaki3, Yu-Hua Lo4,14, Doshun Ito4,...
7EM4
Crystal structure of the PI5P4Kbeta F205L-ITP complex
The GTP-responsiveness of PI5P4Kβ is evolved by a compromised trade-off between activity and specificity Koh Takeuchi1,2,17,*,#, Yoshiki Ikeda3,13,#, Miki Senda4,#, Ayaka Harada4,15, Koji Okuwaki5, Kaori Fukuzawa6, So Nakagawa7, Hong Yang Yu3,4, Lisa Nagase4, Misaki Imai1,2, Mika Sasaki3, Yu-Hua Lo4,14, Doshun Ito4,...
7EM5
Crystal structure of the PI5P4Kbeta F205L-XTP complex
The GTP-responsiveness of PI5P4Kβ is evolved by a compromised trade-off between activity and specificity Koh Takeuchi1,2,17,*,#, Yoshiki Ikeda3,13,#, Miki Senda4,#, Ayaka Harada4,15, Koji Okuwaki5, Kaori Fukuzawa6, So Nakagawa7, Hong Yang Yu3,4, Lisa Nagase4, Misaki Imai1,2, Mika Sasaki3, Yu-Hua Lo4,14, Doshun Ito4,...
7EM6
Crystal structure of the PI5P4Kbeta N203D-ITP complex
The GTP-responsiveness of PI5P4Kβ is evolved by a compromised trade-off between activity and specificity Koh Takeuchi1,2,17,*,#, Yoshiki Ikeda3,13,#, Miki Senda4,#, Ayaka Harada4,15, Koji Okuwaki5, Kaori Fukuzawa6, So Nakagawa7, Hong Yang Yu3,4, Lisa Nagase4, Misaki Imai1,2, Mika Sasaki3, Yu-Hua Lo4,14, Doshun Ito4,...
7EM7
Crystal structure of the PI5P4Kbeta N203D-XTP complex
The GTP-responsiveness of PI5P4Kβ is evolved by a compromised trade-off between activity and specificity Koh Takeuchi1,2,17,*,#, Yoshiki Ikeda3,13,#, Miki Senda4,#, Ayaka Harada4,15, Koji Okuwaki5, Kaori Fukuzawa6, So Nakagawa7, Hong Yang Yu3,4, Lisa Nagase4, Misaki Imai1,2, Mika Sasaki3, Yu-Hua Lo4,14, Doshun Ito4,...
7EM8
Crystal structure of the PI5P4Kbeta T201M-2a-ATP complex
The GTP-responsiveness of PI5P4Kβ is evolved by a compromised trade-off between activity and specificity Koh Takeuchi1,2,17,*,#, Yoshiki Ikeda3,13,#, Miki Senda4,#, Ayaka Harada4,15, Koji Okuwaki5, Kaori Fukuzawa6, So Nakagawa7, Hong Yang Yu3,4, Lisa Nagase4, Misaki Imai1,2, Mika Sasaki3, Yu-Hua Lo4,14, Doshun Ito4,...
7EM9
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I Can Yue,a,b Wangzhen Xiang,c Xiaowen Huang,a,b Yuan Sun,d Jin Xiao,c Kefang Liu,e Zeyu Sun,f Peiwen Qiao,b Hongmei Li,b Jingxuan Gan,g...
7EMA
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I Can Yue,a,b Wangzhen Xiang,c Xiaowen Huang,a,b Yuan Sun,d Jin Xiao,c Kefang Liu,e Zeyu Sun,f Peiwen Qiao,b Hongmei Li,b Jingxuan Gan,g...
7EMB
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I Can Yue,a,b Wangzhen Xiang,c Xiaowen Huang,a,b Yuan Sun,d Jin Xiao,c Kefang Liu,e Zeyu Sun,f Peiwen Qiao,b Hongmei Li,b Jingxuan Gan,g...
7EMC
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I Can Yue,a,b Wangzhen Xiang,c Xiaowen Huang,a,b Yuan Sun,d Jin Xiao,c Kefang Liu,e Zeyu Sun,f Peiwen Qiao,b Hongmei Li,b Jingxuan Gan,g...
7EMD
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I
Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I Can Yue,a,b Wangzhen Xiang,c Xiaowen Huang,a,b Yuan Sun,d Jin Xiao,c Kefang Liu,e Zeyu Sun,f Peiwen Qiao,b Hongmei Li,b Jingxuan Gan,g...
7EMN
The atomic structure of SHP2 E76A mutant
A novel partially open state of SHP2 points to a “multiple gear” regulation mechanism Received for publication, August 22, 2020, and in revised form, March 3, 2021 Published, Papers in Press, March 12, 2021, https://doi.org/10.1016/j.jbc.2021.100538 Youqi Tao1,‡, Jingfei Xie2,3,‡, Qinglu Zhong3,4,‡, Yongyao Wang5,6,‡, ...
7EMY
Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module
ARTICLE Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain Jialiang Wang 1,4, Dandan Li 1,4, Lu Chen1, Wei Cao1, Liangliang Kong2, Wei Zhang1, Tristan Croll3, Zixin Deng 1✉, Jingdan Liang 1✉& Zhijun Wang 1✉ Nonribosomal peptide synthetases (NRPSs) are modular ass...
7EMZ
iron and alpha-ketoglutarate-dependent endoperoxidase NvfI W199F variant
ARTICLE Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI Takahiro Mori 1,2,3,6✉, Rui Zhai1,6, Richiro Ushimaru1,2,4, Yudai Matsuda 5 & Ikuro Abe 1,2✉ Endoperoxide-containing natural products are a group of compounds with structurally unique cyclized peroxide moieties. Although ...
7EN0
Structure and Activity of SLAC1 Channels for Stomatal Signaling in Leaves
Structure and activity of SLAC1 channels for stomatal signaling in leaves Ya-nan Denga,b,c, Hamdy Kashtoha,b,1, Quan Wangd,1, Guang-xiao Zhena,b,c, Qi-yu Lia,b,c, Ling-hui Tanga,b,c, Hai-long Gaod, Chun-rui Zhanga,b,c, Li Qina,b,c, Min Sua,b, Fei Lie, Xia-he Huanga,b, Ying-chun Wanga,b,c, Qi Xiea,b,c, Oliver B. Cl...
7EN1
Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module-after-condensation
ARTICLE Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain Jialiang Wang 1,4, Dandan Li 1,4, Lu Chen1, Wei Cao1, Liangliang Kong2, Wei Zhang1, Tristan Croll3, Zixin Deng 1✉, Jingdan Liang 1✉& Zhijun Wang 1✉ Nonribosomal peptide synthetases (NRPSs) are modular ass...
7EN2
Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module-after-condensation, condensation
ARTICLE Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain Jialiang Wang 1,4, Dandan Li 1,4, Lu Chen1, Wei Cao1, Liangliang Kong2, Wei Zhang1, Tristan Croll3, Zixin Deng 1✉, Jingdan Liang 1✉& Zhijun Wang 1✉ Nonribosomal peptide synthetases (NRPSs) are modular ass...
7EN5
The crystal structure of Escherichia coli MurR in complex with N-acetylglucosamine-6-phosphate
5948–5960 Nucleic Acids Research, 2022, Vol. 50, No. 10 Published online 30 May 2022 https://doi.org/10.1093/nar/gkac442 Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli Ya Zhang1,2,†, Weizhong Chen1,†, Di Wu3,†, Yushi Liu1, Zhaowei Wu1, Jian Li 1, Shu-Yu Zhang 3,...
7EN6
The crystal structure of Escherichia coli MurR in apo form
5948–5960 Nucleic Acids Research, 2022, Vol. 50, No. 10 Published online 30 May 2022 https://doi.org/10.1093/nar/gkac442 Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli Ya Zhang1,2,†, Weizhong Chen1,†, Di Wu3,†, Yushi Liu1, Zhaowei Wu1, Jian Li 1, Shu-Yu Zhang 3,...
7EN7
The crystal structure of Escherichia coli MurR in complex with N-acetylmuramic-acid-6-phosphate
5948–5960 Nucleic Acids Research, 2022, Vol. 50, No. 10 Published online 30 May 2022 https://doi.org/10.1093/nar/gkac442 Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli Ya Zhang1,2,†, Weizhong Chen1,†, Di Wu3,†, Yushi Liu1, Zhaowei Wu1, Jian Li 1, Shu-Yu Zhang 3,...
7EN8
Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-04
Development of Highly Potent Noncovalent Inhibitors of SARS- CoV‑2 3CLpro Ningke Hou,† Lei Shuai,† Lijing Zhang,† Xuping Xie,† Kaiming Tang, Yunkai Zhu, Yin Yu, Wenyi Zhang, Qiaozhu Tan, Gongxun Zhong, Zhiyuan Wen, Chong Wang, Xijun He, Hong Huo, Haishan Gao, You Xu, Jing Xue, Chen Peng, Jing Zou, Craig Schindewolf, Vi...
7EN9
Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-02
Development of Highly Potent Noncovalent Inhibitors of SARS- CoV‑2 3CLpro Ningke Hou,† Lei Shuai,† Lijing Zhang,† Xuping Xie,† Kaiming Tang, Yunkai Zhu, Yin Yu, Wenyi Zhang, Qiaozhu Tan, Gongxun Zhong, Zhiyuan Wen, Chong Wang, Xijun He, Hong Huo, Haishan Gao, You Xu, Jing Xue, Chen Peng, Jing Zou, Craig Schindewolf, Vi...
7ENB
iron and alpha-ketoglutarate-dependent endoperoxidase NvfI with different conformation
ARTICLE Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI Takahiro Mori 1,2,3,6✉, Rui Zhai1,6, Richiro Ushimaru1,2,4, Yudai Matsuda 5 & Ikuro Abe 1,2✉ Endoperoxide-containing natural products are a group of compounds with structurally unique cyclized peroxide moieties. Although ...
7END
Crystal structure of SARS-CoV 3CLpro in complex with the non-covalent inhibitor WU-04
Development of Highly Potent Noncovalent Inhibitors of SARS- CoV‑2 3CLpro Ningke Hou,† Lei Shuai,† Lijing Zhang,† Xuping Xie,† Kaiming Tang, Yunkai Zhu, Yin Yu, Wenyi Zhang, Qiaozhu Tan, Gongxun Zhong, Zhiyuan Wen, Chong Wang, Xijun He, Hong Huo, Haishan Gao, You Xu, Jing Xue, Chen Peng, Jing Zou, Craig Schindewolf, Vi...
7ENE
Crystal structure of MERS-CoV 3CLpro in complex with the non-covalent inhibitor WU-04
Development of Highly Potent Noncovalent Inhibitors of SARS- CoV‑2 3CLpro Ningke Hou,† Lei Shuai,† Lijing Zhang,† Xuping Xie,† Kaiming Tang, Yunkai Zhu, Yin Yu, Wenyi Zhang, Qiaozhu Tan, Gongxun Zhong, Zhiyuan Wen, Chong Wang, Xijun He, Hong Huo, Haishan Gao, You Xu, Jing Xue, Chen Peng, Jing Zou, Craig Schindewolf, Vi...
7ENN
The structure of ALC1 bound to the nucleosome
ARTICLE Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome Li Wang1,2,4, Kangjing Chen1,2,4 & Zhucheng Chen 1,2,3✉ Chromatin remodeler ALC1 (amplification in liver cancer 1) is crucial for repairing damaged DNA. It is autoinhibited and activated by nucleosomal epitopes. Howev...
7ENO
Mutant strain M3 of foot-and-mouth disease virus type O
A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity Hu Dong,a,b Yuanlu Lu,a Yun Zhang,a Suyu Mu,a Nan Wang,c Ping Du,a Xiaoying Zhi,a Xiaobo Wen,d Xiangxi Wang,c Shiqi Sun,a Yanming Zhang,b Huichen Guoa,e aState Key Laboratory of Veterinary Etiological ...
7ENP
wild type of O type Foot-and-mouth disease virus
A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity Hu Dong,a,b Yuanlu Lu,a Yun Zhang,a Suyu Mu,a Nan Wang,c Ping Du,a Xiaoying Zhi,a Xiaobo Wen,d Xiangxi Wang,c Shiqi Sun,a Yanming Zhang,b Huichen Guoa,e aState Key Laboratory of Veterinary Etiological ...
7ENQ
Crystal structure of human NAMPT in complex with compound NAT
ARTICLE Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity Hong Yao1,2,10, Minghui Liu 1,10, Leibo Wang1,10, Yumeng Zu1,10, Chou Wu1,3,10, Chenyu Li1, Ruoxi Zhang1, Haigen Lu4, Feifei Li1, Shuang Xi1, Shuangquan Chen1, Xuanyu Gu1, Tian...
7ENV
crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2 (BRD2-BD1).
research communications Acta Cryst. (2022). F78, 119–127 https://doi.org/10.1107/S2053230X22001066 119 Received 1 December 2021 Accepted 31 January 2022 Edited by R. Sankaranarayanan, Centre for Cellular and Molecular Biology, Hyderabad, India ‡ These authors made an equal contribution. Keywords: BET family; bromodomai...
7ENZ
Crystal structure of Phenanthredinone moiety in complex with the second bromodomain of BRD2 (BRD2-BD2).
research communications Acta Cryst. (2022). F78, 119–127 https://doi.org/10.1107/S2053230X22001066 119 Received 1 December 2021 Accepted 31 January 2022 Edited by R. Sankaranarayanan, Centre for Cellular and Molecular Biology, Hyderabad, India ‡ These authors made an equal contribution. Keywords: BET family; bromodomai...
7EO0
FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY C4
Two Cross-Protective Antigen Sites on Foot-and-Mouth Disease Virus Serotype O Structurally Revealed by Broadly Neutralizing Antibodies from Cattle Kun Li,a Yong He,b,c,d,e Li Wang,a Pinghua Li,a Sheng Wang,a Pu Sun,a Huifang Bao,a Yimei Cao,a Xuerong Liu,f Guoqiang Zhu,a Yali Song,a Xingwen Bai,a Xueqing Ma,a Yuanfang ...
7EO5
Crystal structure of pyrano 1,3, oxazine derivative in complex with the second bromodomain of BRD2
research communications Acta Cryst. (2022). F78, 119–127 https://doi.org/10.1107/S2053230X22001066 119 Received 1 December 2021 Accepted 31 January 2022 Edited by R. Sankaranarayanan, Centre for Cellular and Molecular Biology, Hyderabad, India ‡ These authors made an equal contribution. Keywords: BET family; bromodomai...
7EO7
Crystal structure of HCoV-NL63 3C-like protease in complex with an inhibitor Shikonin
Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus Yuting Zhang,a,b Hongxia Gao,c Xiaohui Hu,a Qisheng Wang,d Fanglin Zhong,e,f Xuelan Zhou,a,b Cheng Lin,e,f Yang Yang,g Junkang Wei,h Weian Du,i Huaiqiu Huang,i Huan Zhou,d Wei He,b Hua Zhang...
7EO8
Crystal structure of SARS coronavirus main protease in complex with an inhibitor Shikonin
Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus Yuting Zhang,a,b Hongxia Gao,c Xiaohui Hu,a Qisheng Wang,d Fanglin Zhong,e,f Xuelan Zhou,a,b Cheng Lin,e,f Yang Yang,g Junkang Wei,h Weian Du,i Huaiqiu Huang,i Huan Zhou,d Wei He,b Hua Zhang...
7EO9
Crystal structure of KIF1A Motor-Neck domain with ADP-Mg-AlFx
Article A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle Manatsu Morikawa1, Nivedita U Jerath2,3, Tadayuki Ogawa1,4 , Momo Morikawa1,5 , Yosuke Tanaka1 , Michael E Shy2, Stephan Zuchner6 & Nobutaka Hirokawa1,* Abstract The mechanochemical coupling of ATP...
7EOB
Crystal structure of KIF1A Motor-Neck domain E239K mutant with ADP-Mg-AlFx
Article A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle Manatsu Morikawa1, Nivedita U Jerath2,3, Tadayuki Ogawa1,4 , Momo Morikawa1,5 , Yosuke Tanaka1 , Michael E Shy2, Stephan Zuchner6 & Nobutaka Hirokawa1,* Abstract The mechanochemical coupling of ATP...
7EOD
MITF HLHLZ Delta AKE
ARTICLE A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy Zaizhou Liu1,12, Kaige Chen2,9,12, Jun Dai3,4, Peng Xu1,5, Wei Sun6, Wanlin Liu6, Zhixin Zhao1, Steven P. Bennett7, Peifeng Li1, Tiancheng Ma1, Yuqi Lin1, Akinori Kawakami3, Jing Yu 1,...
7EOY
Engineered Hepatitis B virus core antigen T=3
International Journal of Molecular Sciences Article Structural and Functional Characterizations of Cancer Targeting Nanoparticles Based on Hepatitis B Virus Capsid Yunseok Heo 1,†, Hyeongseop Jeong 2,3,†, Youngki Yoo 4, Ji-Hye Yun 1,5 , Bumhan Ryu 6, Young-je Cha 4, Bo-Ram Lee 7, Ye-Eun Jeon 1, Jongmin Kim 1, Sojin ...
7EP6
Engineered Hepatitis B virus core antigen T=4
International Journal of Molecular Sciences Article Structural and Functional Characterizations of Cancer Targeting Nanoparticles Based on Hepatitis B Virus Capsid Yunseok Heo 1,†, Hyeongseop Jeong 2,3,†, Youngki Yoo 4, Ji-Hye Yun 1,5 , Bumhan Ryu 6, Young-je Cha 4, Bo-Ram Lee 7, Ye-Eun Jeon 1, Jongmin Kim 1, Sojin ...
7EP7
The complex structure of Gpsm2 and Whirlin
Shi et al., Sci. Adv. 8, eabn4556 (2022) 10 June 2022 SCIE N C E A D V A NCES | RESEA R CH A RT ICL E 1 of 11 BI O CHEM ISTRY Promotion of row 1–specific tip complex condensates by Gpsm2-Gi provides insights into row identity of the tallest stereocilia Yingdong Shi1†, Lin Lin2†, Chao Wang1*, Jinwei Zhu2* The me...
7EP8
Crystal structure of PCNA from Neurospora crassa
Interdomain connecting loop and J loop structures determine cross-species compatibility of PCNA Received for publication, May 3, 2021, and in revised form, June 17, 2021 Published, Papers in Press, June 25, 2021, https://doi.org/10.1016/j.jbc.2021.100911 Premlata Kumari1,2,‡, Rajivgandhi Sundaram3,4,‡, Kodavati Manohar...
7EPG
Crystal structure of E.coli CcdB mutant S12G
RESEARCH ARTICLE Mechanistic insights into global suppressors of protein folding defects Gopinath Chattopadhyay1☯, Jayantika Bhowmick1☯, Kavyashree ManjunathID2, Shahbaz Ahmed1, Parveen GoyalID3, Raghavan VaradarajanID1* 1 Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India, 2 Centre for Chemical B...
7EPI
Crystal structure of E.coli CcdB mutant S60E
RESEARCH ARTICLE Mechanistic insights into global suppressors of protein folding defects Gopinath Chattopadhyay1☯, Jayantika Bhowmick1☯, Kavyashree ManjunathID2, Shahbaz Ahmed1, Parveen GoyalID3, Raghavan VaradarajanID1* 1 Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India, 2 Centre for Chemical B...
7EPJ
Crystal structure of E.coli CcdB mutant V46L
RESEARCH ARTICLE Mechanistic insights into global suppressors of protein folding defects Gopinath Chattopadhyay1☯, Jayantika Bhowmick1☯, Kavyashree ManjunathID2, Shahbaz Ahmed1, Parveen GoyalID3, Raghavan VaradarajanID1* 1 Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India, 2 Centre for Chemical B...
7EPM
human LDHC complexed with NAD+ and ethylamino acetic acid
ORIGINAL ARTICLE Identification of human LDHC4 as a potential target for anticancer drug discovery Hong Tana,y, Huali Wangb,y, Jinhu Mab,y, Hui Dengc, Qinghua Hed,*, Qiang Chenb,*, Qinglian Zhangc,* aThe Research Institute of Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China bState Key Laboratory ...
7EPU
Crystal structure of HsALC1
ARTICLE Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome Li Wang1,2,4, Kangjing Chen1,2,4 & Zhucheng Chen 1,2,3✉ Chromatin remodeler ALC1 (amplification in liver cancer 1) is crucial for repairing damaged DNA. It is autoinhibited and activated by nucleosomal epitopes. Howev...
7EPX
S protein of SARS-CoV-2 in complex with GW01
Wang et al. Cell Discovery (2022) 8:36 Cell Discovery https://doi.org/10.1038/s41421-022-00401-6 www.nature.com/celldisc A R T I C L E O p e n A c c e s s Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses Ying...
7EPZ
Overall structure of Erastin-bound xCT-4F2hc complex
LETTER TO THE EDITOR OPEN The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis © The Author(s) 2022 Cell Research (2022) 32:687–690; https://doi.org/10.1038/s41422-022-00642-w Dear Editor, Ferroptosis is an iron-dependent, non-apoptotic form of regulated c...
7EQ4
Crystal Structure of the N-terminus of Nonstructural protein 1 from SARS-CoV-2
Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1 Kaitao Zhao,a Zunhui Ke,b Hongbing Hu,b Yahui Liu,c Aixin Li,a Rong Hua,a Fangteng Guo,a Junfeng Xiao,c Yu Zhang,d Ling Duan,b Xin-Fu Yan,e Yong-Gui Gao,e Bing Liu,f,g Yuchen Xia,a Yan Lic,h aState Key Laboratory of Virology and Hubei...
7EQB
Crystal structure of the dimerization domain of ZEN-4
Mechanistic insights into central spindle assembly mediated by the centralspindlin complex Han Pana,b,1, Ruifang Guanb,1,2, Ruixue Zhaob,1, Guangshuo Oua,b,3, and Zhucheng Chena,b,c,3 aMinistry of Education (MOE) Key Laboratory of Protein Science, Tsinghua University, Beijing 100084, People’s Republic of China; bSch...
7EQC
Crystal structure of the mini-centralspindlin complex
Mechanistic insights into central spindle assembly mediated by the centralspindlin complex Han Pana,b,1, Ruifang Guanb,1,2, Ruixue Zhaob,1, Guangshuo Oua,b,3, and Zhucheng Chena,b,c,3 aMinistry of Education (MOE) Key Laboratory of Protein Science, Tsinghua University, Beijing 100084, People’s Republic of China; bSch...
7EQH
Crystal structure of Arabidopsis GUN2/HO1 in complex with heme
Enzymological and structural characterization of Arabidopsis thaliana heme oxygenase-1 Jia Wang1, Xiaoyi Li2, Jing-Wen Chang1, Tong Ye1, Ying Mao1, Xiao Wang1 and Lin Liu1 1 School of Life Sciences, Anhui University, Hefei, China 2 Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijin...
7EQI
ChlB3 [Aceyltransferase]
Citation: Saeed, A.U.; Rahman, M.U.; Chen, H.-F.; Zheng, J. Structural Insight of KSIII (β-Ketoacyl-ACP Synthase)-like Acyltransferase ChlB3 in the Biosynthesis of Chlorothricin. Molecules 2022, 27, 6405. https:// doi.org/10.3390/molecules27196405 Academic Editors: Lothar Elling and Athina Geronikaki Received: 6 August...
7EQJ
crystal structure of E. coli Valine tRNA
Unique anticodon loop conformation with the flipped-out wobble nucleotide in the crystal structure of unbound tRNAVal HYEONJU JEONG and JUNGWOOK KIM Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Korea ABSTRACT During protein synthesis on ribosome, tRNA recognizes its cognate codon...
7EQL
Crystal structure of (+)-pulegone reductase from Mentha piperita
ORIGINAL RESEARCH published: 30 November 2021 doi: 10.3389/fpls.2021.780970 Edited by: Supaart Sirikantaramas, Chulalongkorn University, Thailand Reviewed by: Dinesh A. Nagegowda, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research (CSIR), India Raimund Nagel, University of ...
7EQM
Apo Truncated VhChiP (Delta 1-19)
Structural displacement model of chitooligosaccharide transport through chitoporin Received for publication, February 20, 2023, and in revised form, June 26, 2023 Published, Papers in Press, July 1, 2023, https://doi.org/10.1016/j.jbc.2023.105000 Surapoj Sanram‡, Anuwat Aunkham‡, Robert Robinson, and Wipa Suginta* From...
7EQR
Crystal structure of Truncated (Delta 1-19) Chitoporin VhChiP from Vibrio harveyi in complex with chitohexaose
Structural displacement model of chitooligosaccharide transport through chitoporin Received for publication, February 20, 2023, and in revised form, June 26, 2023 Published, Papers in Press, July 1, 2023, https://doi.org/10.1016/j.jbc.2023.105000 Surapoj Sanram‡, Anuwat Aunkham‡, Robert Robinson, and Wipa Suginta* From...
7EQS
Crystal structure of capsid P domain of norovirus GI.3 DSV
Structural Insight into Terminal Galactose Recognition by Two Non-HBGA Binding GI.3 Noroviruses Chenlong Wang,a,b,d Huiling Kang,a,b,c Ming Tan,e,f Jingyuan Cong,a,d Dan Su,c Xuemei Li,a Yutao Chena aNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China bSchool o...
7EQT
Crystal structure of capsid P domain of norovirus GI.3 DSV complexed with Gala1-3Galb1-4Glc
Structural Insight into Terminal Galactose Recognition by Two Non-HBGA Binding GI.3 Noroviruses Chenlong Wang,a,b,d Huiling Kang,a,b,c Ming Tan,e,f Jingyuan Cong,a,d Dan Su,c Xuemei Li,a Yutao Chena aNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China bSchool o...
7EQV
Crystal structure of JMJD2A complexed with 3,4-dihydroxybenzoic acid
Liu et al. Journal of Biomedical Science (2022) 29:29 https://doi.org/10.1186/s12929-022-00812-3 RESEARCH Natural product myricetin is a pan‑KDM4 inhibitor which with poly lactic‑co‑glycolic acid formulation effectively targets castration‑resistant prostate cancer Jai‑Shin Liu1,2†, Wei‑Kai Fang1,3†, Shan...
7EQW
Crystal structure of capsid P domain of norovirus GI.3 DSV complexed with NA2 N-glycan
Structural Insight into Terminal Galactose Recognition by Two Non-HBGA Binding GI.3 Noroviruses Chenlong Wang,a,b,d Huiling Kang,a,b,c Ming Tan,e,f Jingyuan Cong,a,d Dan Su,c Xuemei Li,a Yutao Chena aNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China bSchool o...
7EQX
Crystal structure of an Aedes aegypti procarboxypeptidase B1
Research Article Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection Edem Gavor1, Yeu Khai Choong1, Nikhil Kumar Tulsian1,2, Digant Nayak1, Fakhriedzwan Idris3,4, Hariharan Sivaraman1, Donald Heng Rong Ting3,4, Alonso Sylvie3,4, Yu Keung Mok1, R Manjunatha Kini1...
7EQZ
Crystal structure of Carboxypeptidase B complexed with Potato Carboxypeptidase Inhibitor
F U L L - L E N G T H P A P E R Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non- mosquito insect carboxypeptidase inhibition mechanism Edem Gavor1 | Yeu Khai Choong1 | Chacko Jobichen1 | Yu Keung Mok1 | R. Manjunatha Kini1,2 | J. Sivaraman1 1Department of ...
7ER0
Crystal structure of capsid P domain of norovirus GI.3 VA115
Structural Insight into Terminal Galactose Recognition by Two Non-HBGA Binding GI.3 Noroviruses Chenlong Wang,a,b,d Huiling Kang,a,b,c Ming Tan,e,f Jingyuan Cong,a,d Dan Su,c Xuemei Li,a Yutao Chena aNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China bSchool o...
7ER1
Crystal structure of capsid P domain of norovirus GI.3 VA115 complexed with Gala1-3Galb1-4Glc
Structural Insight into Terminal Galactose Recognition by Two Non-HBGA Binding GI.3 Noroviruses Chenlong Wang,a,b,d Huiling Kang,a,b,c Ming Tan,e,f Jingyuan Cong,a,d Dan Su,c Xuemei Li,a Yutao Chena aNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China bSchool o...
7ER2
Crystal structure of EGFR 696-1022 T790M/C797S in complex with LS_2_40
Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFRT790M/C797S Mutants Shan Li,∇Tao Zhang,∇Su-Jie Zhu,∇Chong Lei, Mengzhen Lai, Lijie Peng, Linjiang Tong, Zilu Pang, Xiaoyun Lu, Jian Ding, Xiaomei Ren,* Cai-Hong Yun,* Hua Xie,* and Ke Ding* Cite This: ACS Med. Chem. Lett. 2022, 13, 196−202 Read Onlin...
7ERP
The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from Cronobacter sakazakii (sulfite-bound form)
Crystal structures of YeiE from Cronobacter sakazakii and the role of sulfite tolerance in gram-negative bacteria Seokho Honga,b,1 , Jinshil Kima,b,1 , Eunshin Choa,b , Soohui Naa,b, Yeon-Ji Yooc, You-Hee Choc , Sangryeol Ryua,b,2, and Nam-Chul Haa,b,2 Edited by Gisela Storz, National Institute of Child Health and Human...
7ERQ
The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from Cronobacter sakazakii (ligand-free form)
Crystal structures of YeiE from Cronobacter sakazakii and the role of sulfite tolerance in gram-negative bacteria Seokho Honga,b,1 , Jinshil Kima,b,1 , Eunshin Choa,b , Soohui Naa,b, Yeon-Ji Yooc, You-Hee Choc , Sangryeol Ryua,b,2, and Nam-Chul Haa,b,2 Edited by Gisela Storz, National Institute of Child Health and Human...
7ERX
Glycosyltransferase in complex with UDP and STB
ARTICLE Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides Jinzhu Zhang1,5, Minghai Tang1,5, Yujie Chen1,5, Dan Ke1, Jie Zhou1, Xinyu Xu1, Wenxian Yang1, Jianxiong He1, Haohao Dong 1, Yuquan Wei1, James H. Naismith 1,2,3, Yi Lin4, Xiaofeng Zhu 1,6✉& Wei Cheng 1...
7ERY
apo form of the glycosyltransferase
ARTICLE Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides Jinzhu Zhang1,5, Minghai Tang1,5, Yujie Chen1,5, Dan Ke1, Jie Zhou1, Xinyu Xu1, Wenxian Yang1, Jianxiong He1, Haohao Dong 1, Yuquan Wei1, James H. Naismith 1,2,3, Yi Lin4, Xiaofeng Zhu 1,6✉& Wei Cheng 1...
7ES0
a rice glycosyltransferase in complex with UDP and REX
ARTICLE Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides Jinzhu Zhang1,5, Minghai Tang1,5, Yujie Chen1,5, Dan Ke1, Jie Zhou1, Xinyu Xu1, Wenxian Yang1, Jianxiong He1, Haohao Dong 1, Yuquan Wei1, James H. Naismith 1,2,3, Yi Lin4, Xiaofeng Zhu 1,6✉& Wei Cheng 1...
7ES1
glycosyltransferase in complex with UDP and ST
ARTICLE Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides Jinzhu Zhang1,5, Minghai Tang1,5, Yujie Chen1,5, Dan Ke1, Jie Zhou1, Xinyu Xu1, Wenxian Yang1, Jianxiong He1, Haohao Dong 1, Yuquan Wei1, James H. Naismith 1,2,3, Yi Lin4, Xiaofeng Zhu 1,6✉& Wei Cheng 1...
7ES2
a mutant of glycosyktransferase in complex with UDP and Reb D
ARTICLE Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides Jinzhu Zhang1,5, Minghai Tang1,5, Yujie Chen1,5, Dan Ke1, Jie Zhou1, Xinyu Xu1, Wenxian Yang1, Jianxiong He1, Haohao Dong 1, Yuquan Wei1, James H. Naismith 1,2,3, Yi Lin4, Xiaofeng Zhu 1,6✉& Wei Cheng 1...
7ESA
the complex structure of flavin transferase FmnB complexed with FAD
Received: 29 August 2021 Revised: 5 October 2021 Accepted: 20 October 2021 DOI: 10.1002/mco2.99 O R I G I NA L A RT I C L E Structural insights into the catalytic and inhibitory mechanisms of the flavin transferase FmnB in Listeria monocytogenes Yanhui Zheng Weizhu Yan Chao Dou Dan Zhou Yunying Chen Ying Jin Lulu Yang ...
7ESB
FmnB complexed with ATP
Received: 29 August 2021 Revised: 5 October 2021 Accepted: 20 October 2021 DOI: 10.1002/mco2.99 O R I G I NA L A RT I C L E Structural insights into the catalytic and inhibitory mechanisms of the flavin transferase FmnB in Listeria monocytogenes Yanhui Zheng Weizhu Yan Chao Dou Dan Zhou Yunying Chen Ying Jin Lulu Yang ...
7ESC
FmnB complexed with AMP
Received: 29 August 2021 Revised: 5 October 2021 Accepted: 20 October 2021 DOI: 10.1002/mco2.99 O R I G I NA L A RT I C L E Structural insights into the catalytic and inhibitory mechanisms of the flavin transferase FmnB in Listeria monocytogenes Yanhui Zheng Weizhu Yan Chao Dou Dan Zhou Yunying Chen Ying Jin Lulu Yang ...
7ESD
Mature Donggang virus
Replication is the key barrier during the dual-host adaptation of mosquito-borne flaviviruses Yanan Zhanga,b,1 , Dening Liangc,1 , Fei Yuana, Yiran Yana,b, Zuoshu Wangd, Pan Liuc, Qi Yuc, Xing Zhange , Xiangxi Wangc,2, and Aihua Zhenga,b,f,2 Edited by Scott C. Weaver, The University of Texas Medical Branch at Galveston,...
7ESI
Crystal structure of the collagenase unit of a Vibrio collagenase from Vibrio harveyi VHJR7 at 1. 8 angstrom resolution.
ARTICLE Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis Yan Wang1,2,3,10, Peng Wang2,3,10, Hai-Yan Cao1,3, Hai-Tao Ding4, Hai-Nan Su1,3, Shi-Cheng Liu5, Guangfeng Liu6, Xia Zhang5, Chun-Yang Li2,3, Ming Peng1,3, Fuchuan Li 7, Shengying Li 1,3, Yin Chen 2,8, Xiu-Lan C...
7ESK
Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, Ligand free form
Structural and functional analysis of gum arabic L-rhamnose- α-1,4-D-glucuronate lyase establishes a novel polysaccharide lyase family Received for publication, May 21, 2021, and in revised form, July 20, 2021 Published, Papers in Press, July 23, 2021, https://doi.org/10.1016/j.jbc.2021.101001 Tatsuya Kondo1 , Miyu Kic...
7ESL
Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, N247A N-glycan free form
Structural and functional analysis of gum arabic L-rhamnose- α-1,4-D-glucuronate lyase establishes a novel polysaccharide lyase family Received for publication, May 21, 2021, and in revised form, July 20, 2021 Published, Papers in Press, July 23, 2021, https://doi.org/10.1016/j.jbc.2021.101001 Tatsuya Kondo1 , Miyu Kic...
7ESM
Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, L-Rha complex
Structural and functional analysis of gum arabic L-rhamnose- α-1,4-D-glucuronate lyase establishes a novel polysaccharide lyase family Received for publication, May 21, 2021, and in revised form, July 20, 2021 Published, Papers in Press, July 23, 2021, https://doi.org/10.1016/j.jbc.2021.101001 Tatsuya Kondo1 , Miyu Kic...
7ESN
Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, H105F Rha-GlcA complex
Structural and functional analysis of gum arabic L-rhamnose- α-1,4-D-glucuronate lyase establishes a novel polysaccharide lyase family Received for publication, May 21, 2021, and in revised form, July 20, 2021 Published, Papers in Press, July 23, 2021, https://doi.org/10.1016/j.jbc.2021.101001 Tatsuya Kondo1 , Miyu Kic...
7ESX
Crystal structure of Wolbachia cytoplasmic incompatibility factor CidA from wPip
Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors Yunjie Xiaoa,b,1, Hongli Chenc,1, Haofeng Wanga,b,d,1, Mengwen Zhangc,e,1, Xia Chena, Jason M. Berkc, Lilin Zhanga, Yi Weia, Wenling Lia, Wen Cuia,d, Fenghua Wanga, Qianfan Wanga, Can Cuia, Ting Lia, Cheng ...
7ESY
Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CidA and CidBND1-ND2 from wPip
Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors Yunjie Xiaoa,b,1, Hongli Chenc,1, Haofeng Wanga,b,d,1, Mengwen Zhangc,e,1, Xia Chena, Jason M. Berkc, Lilin Zhanga, Yi Weia, Wenling Lia, Wen Cuia,d, Fenghua Wanga, Qianfan Wanga, Can Cuia, Ting Lia, Cheng ...
7ESZ
Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CinA and CinB with Mn2+ from wPip
Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors Yunjie Xiaoa,b,1, Hongli Chenc,1, Haofeng Wanga,b,d,1, Mengwen Zhangc,e,1, Xia Chena, Jason M. Berkc, Lilin Zhanga, Yi Weia, Wenling Lia, Wen Cuia,d, Fenghua Wanga, Qianfan Wanga, Can Cuia, Ting Lia, Cheng ...
7ET0
Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CinA and CinB from wPip
Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors Yunjie Xiaoa,b,1, Hongli Chenc,1, Haofeng Wanga,b,d,1, Mengwen Zhangc,e,1, Xia Chena, Jason M. Berkc, Lilin Zhanga, Yi Weia, Wenling Lia, Wen Cuia,d, Fenghua Wanga, Qianfan Wanga, Can Cuia, Ting Lia, Cheng ...
7ET1
Cryo-EM structure of the gastric proton pump K791S/E820D/Y340N/E936V/Y799W mutant in K+-occluded (K+)E2-AlF state
ARTICLE Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations Kazuhiro Abe 1,2✉, Kenta Yamamoto1,2, Katsumasa Irie3, Tomohiro Nishizawa4 & Atsunori Oshima 1,2 The gastric H+,K+-ATPase mediates electroneutral exchange of 1H+/1K+ per ATP hydro- lysed across the membrane. Previous structur...
7ET2
Human Cytomegalovirus, C12 portal
ARTICLE Structural basis for genome packaging, retention, and ejection in human cytomegalovirus Zhihai Li 1,3, Jingjing Pang 1,2,3, Lili Dong 1,3 & Xuekui Yu 1,2✉ How the human cytomegalovirus (HCMV) genome—the largest among human herpes- viruses—is packaged, retained, and ejected remains unclear. We present the in sit...
7ET3
C5 portal vertex in the enveloped virion capsid
ARTICLE Structural basis for genome packaging, retention, and ejection in human cytomegalovirus Zhihai Li 1,3, Jingjing Pang 1,2,3, Lili Dong 1,3 & Xuekui Yu 1,2✉ How the human cytomegalovirus (HCMV) genome—the largest among human herpes- viruses—is packaged, retained, and ejected remains unclear. We present the in sit...
7ET4
Crystal structure of Arabidopsis TEM1 AP2 domain
TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis Hongmiao Hua,b,c,1, Shu Tiana,c,1, Guohui Xieb, Rui Liub, Nana Wangb, Sisi Lib, Yuehui Hea,d,e,2, and Jiamu Dub,2 aNational Key Laboratory of Plant Molecular Genetics and Shanghai Center f...