protein_name stringlengths 4 4 | structure_title stringlengths 3 322 | main_text stringlengths 0 302k |
|---|---|---|
7ZSK | K3DAK4 bimodule core of BGC11 from Brevibacillus brevis. | Tittes et al., Sci. Adv. 8, eabo6918 (2022) 21 September 2022
SCIE N C E A D V A NCES | RESEA R CH A RT ICL E
1 of 9
ST RUCTURAL B IOL OG Y
The structure of a polyketide synthase bimodule core
Yves U. Tittes, Dominik A. Herbst†, Solène F. X. Martin, Hugo Munoz-Hernandez,
Roman P. Jakob, Timm Maier*
Polyketide syn... |
7ZSL | human purine nucleoside phosphorylase in complex with JS-196 | Design, Synthesis, Biological Evaluation, and Crystallographic Study
of Novel Purine Nucleoside Phosphorylase Inhibitors
Jan Skácel,⊥Stefan Djukic,⊥Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský,
Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldři... |
7ZSM | human purine nucleoside phosphorylase in complex with JS-375 | Design, Synthesis, Biological Evaluation, and Crystallographic Study
of Novel Purine Nucleoside Phosphorylase Inhibitors
Jan Skácel,⊥Stefan Djukic,⊥Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský,
Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldři... |
7ZSN | human purine nucleoside phosphorylase in complex with JS-379 | Design, Synthesis, Biological Evaluation, and Crystallographic Study
of Novel Purine Nucleoside Phosphorylase Inhibitors
Jan Skácel,⊥Stefan Djukic,⊥Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský,
Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldři... |
7ZSO | human purine nucleoside phosphorylase in complex with JS-554 | Design, Synthesis, Biological Evaluation, and Crystallographic Study
of Novel Purine Nucleoside Phosphorylase Inhibitors
Jan Skácel,⊥Stefan Djukic,⊥Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský,
Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldři... |
7ZSP | human purine nucleoside phosphorylase in complex with JS-555 | Design, Synthesis, Biological Evaluation, and Crystallographic Study
of Novel Purine Nucleoside Phosphorylase Inhibitors
Jan Skácel,⊥Stefan Djukic,⊥Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský,
Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldři... |
7ZSQ | human purine nucleoside phosphorylase in complex with JS-555 | Design, Synthesis, Biological Evaluation, and Crystallographic Study
of Novel Purine Nucleoside Phosphorylase Inhibitors
Jan Skácel,⊥Stefan Djukic,⊥Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský,
Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldři... |
7ZSR | purine nucleoside phosphorylase in complex with JS-379 | Design, Synthesis, Biological Evaluation, and Crystallographic Study
of Novel Purine Nucleoside Phosphorylase Inhibitors
Jan Skácel,⊥Stefan Djukic,⊥Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský,
Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldři... |
7ZSS | cryo-EM structure of D614 spike in complex with de novo designed binder | 176 | Nature | Vol 617 | 4 May 2023
Article
De novo design of protein interactions with
learned surface fingerprints
Pablo Gainza1,2,10,11, Sarah Wehrle1,2,11, Alexandra Van Hall-Beauvais1,2,11, Anthony Marchand1,2,11,
Andreas Scheck1,2,11, Zander Harteveld1,2, Stephen Buckley1,2, Dongchun Ni3,4, Shuguang Tan5,... |
7ZST | Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with FLA-01 | Discovery of Small-Molecule Allosteric Inhibitors of PfATC as
Antimalarials
Chao Wang,# Bidong Zhang,# Arne Krüger, Xiaochen Du, Lidia Visser, Alexander S S Dömling,
Carsten Wrenger, and Matthew R Groves*
Cite This: J. Am. Chem. Soc. 2022, 144, 19070−19077
Read Online
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sı... |
7ZSU | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor | Structure Based Discovery of Inhibitors of CYP125 and
CYP142 from Mycobacterium tuberculosis
Mona M. Katariya+,[b] Matthew Snee+,[c] Richard B. Tunnicliffe,[c] Madeline E. Kavanagh,[b, d]
Helena I. M. Boshoff,[e] Cecilia N. Amadi,[c] Colin W. Levy,[c] Andrew W. Munro,[c] Chris Abell,[b]
David Leys,[c] Anthony G. Coyne,... |
7ZSV | F32V Cytochrome c prime beta from Methylococcus capsulatus (Bath) Chemically Reduced Ferrous Form | A heme pocket aromatic quadrupole modulates gas binding
to cytochrome c0-β: Implications for NO sensors
Received for publication, January 24, 2023, and in revised form, April 15, 2023 Published, Papers in Press, April 24, 2023,
https://doi.org/10.1016/j.jbc.2023.104742
Hannah R. Adams1 , Dimitri A. Svistunenko1 , Micha... |
7ZSW | F32V Cytochrome c prime beta from Methylococcus capsulatus (Bath): NO Complex | A heme pocket aromatic quadrupole modulates gas binding
to cytochrome c0-β: Implications for NO sensors
Received for publication, January 24, 2023, and in revised form, April 15, 2023 Published, Papers in Press, April 24, 2023,
https://doi.org/10.1016/j.jbc.2023.104742
Hannah R. Adams1 , Dimitri A. Svistunenko1 , Micha... |
7ZSX | F32V Cytochrome c prime beta from Methylococcus capsulatus (Bath): CO Complex | A heme pocket aromatic quadrupole modulates gas binding
to cytochrome c0-β: Implications for NO sensors
Received for publication, January 24, 2023, and in revised form, April 15, 2023 Published, Papers in Press, April 24, 2023,
https://doi.org/10.1016/j.jbc.2023.104742
Hannah R. Adams1 , Dimitri A. Svistunenko1 , Micha... |
7ZSZ | Crystal structure of the GH11 domain of a multidomain xylanase from the hindgut metagenome of Trinervitermes trinervoides | RESEARCH ARTICLE
Structural and biophysical characterization of
the multidomain xylanase Xyl
Valentine AnyeID, Robert F. Kruger, Wolf-Dieter SchubertID*
Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences,
University of Pretoria, Pretoria, South Africa
* wolf-dieter.schub... |
7ZT0 | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor | Structure Based Discovery of Inhibitors of CYP125 and
CYP142 from Mycobacterium tuberculosis
Mona M. Katariya+,[b] Matthew Snee+,[c] Richard B. Tunnicliffe,[c] Madeline E. Kavanagh,[b, d]
Helena I. M. Boshoff,[e] Cecilia N. Amadi,[c] Colin W. Levy,[c] Andrew W. Munro,[c] Chris Abell,[b]
David Leys,[c] Anthony G. Coyne,... |
7ZT2 | Structure of E8 TCR in complex with human MR1 bound to 5-OP-RU | ARTICLE
Promiscuous recognition of MR1 drives self-reactive
mucosal-associated invariant T cell responses
Andrew Chancellor1*, Robert Alan Simmons2*, Rahul C. Khanolkar2, Vladimir Nosi1,3, Aisha Beshirova1, Giuliano Berloffa1,
Rodrigo Colombo1, Vijaykumar Karuppiah2, Johanne M. Pentier2, Vanessa Tubb2, Hemza ... |
7ZT3 | Structure of E8 TCR in complex in human MR1 K43A | ARTICLE
Promiscuous recognition of MR1 drives self-reactive
mucosal-associated invariant T cell responses
Andrew Chancellor1*, Robert Alan Simmons2*, Rahul C. Khanolkar2, Vladimir Nosi1,3, Aisha Beshirova1, Giuliano Berloffa1,
Rodrigo Colombo1, Vijaykumar Karuppiah2, Johanne M. Pentier2, Vanessa Tubb2, Hemza ... |
7ZT4 | Structure of E8 TCR in complex with human MR1 bound to 6FP | ARTICLE
Promiscuous recognition of MR1 drives self-reactive
mucosal-associated invariant T cell responses
Andrew Chancellor1*, Robert Alan Simmons2*, Rahul C. Khanolkar2, Vladimir Nosi1,3, Aisha Beshirova1, Giuliano Berloffa1,
Rodrigo Colombo1, Vijaykumar Karuppiah2, Johanne M. Pentier2, Vanessa Tubb2, Hemza ... |
7ZT5 | Structure of E8 TCR in complex in human MR1 bound to 3FSA | ARTICLE
Promiscuous recognition of MR1 drives self-reactive
mucosal-associated invariant T cell responses
Andrew Chancellor1*, Robert Alan Simmons2*, Rahul C. Khanolkar2, Vladimir Nosi1,3, Aisha Beshirova1, Giuliano Berloffa1,
Rodrigo Colombo1, Vijaykumar Karuppiah2, Johanne M. Pentier2, Vanessa Tubb2, Hemza ... |
7ZT6 | Cryo-EM structure of Ku 70/80 bound to inositol hexakisphosphate | Nucleic Acids Research , 2023, 51 , 11732–11747
https://doi.org/10.1093/nar/gkad863
Advance access publication date: 23 October 2023
Genome integrity, repair and replication
Structural and functional basis of inositol hexaphosphate
stimulation of NHEJ through stabilization of Ku-XLF
int er action
Antonia Kefala ... |
7ZT7 | Structure of E8 TCR in complex in human MR1 bound to 5FSA | ARTICLE
Promiscuous recognition of MR1 drives self-reactive
mucosal-associated invariant T cell responses
Andrew Chancellor1*, Robert Alan Simmons2*, Rahul C. Khanolkar2, Vladimir Nosi1,3, Aisha Beshirova1, Giuliano Berloffa1,
Rodrigo Colombo1, Vijaykumar Karuppiah2, Johanne M. Pentier2, Vanessa Tubb2, Hemza ... |
7ZT8 | Structure of E8 TCR in complex in human MR1 bound to 3FBA | ARTICLE
Promiscuous recognition of MR1 drives self-reactive
mucosal-associated invariant T cell responses
Andrew Chancellor1*, Robert Alan Simmons2*, Rahul C. Khanolkar2, Vladimir Nosi1,3, Aisha Beshirova1, Giuliano Berloffa1,
Rodrigo Colombo1, Vijaykumar Karuppiah2, Johanne M. Pentier2, Vanessa Tubb2, Hemza ... |
7ZT9 | Structure of E8 TCR in complex in human MR1 bound to 4FBA | ARTICLE
Promiscuous recognition of MR1 drives self-reactive
mucosal-associated invariant T cell responses
Andrew Chancellor1*, Robert Alan Simmons2*, Rahul C. Khanolkar2, Vladimir Nosi1,3, Aisha Beshirova1, Giuliano Berloffa1,
Rodrigo Colombo1, Vijaykumar Karuppiah2, Johanne M. Pentier2, Vanessa Tubb2, Hemza ... |
7ZTB | Structure of the Salmonella tRNA pyrophosphokinase CapRel | 132 | Nature | Vol 612 | 1 December 2022
Article
Direct activation of a bacterial innate
immune system by a viral capsid protein
Tong Zhang1, Hedvig Tamman2, Kyo Coppieters ’t Wallant3, Tatsuaki Kurata4,
Michele LeRoux1, Sriram Srikant1, Tetiana Brodiazhenko5, Albinas Cepauskas2,
Ariel Talavera2, Chloe Martens... |
7ZTH | Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the open conformation | Published online 28 June 2023
Nucleic Acids Research, 2023, Vol. 51, No. 15 8237–8254
https://doi.org/10.1093/nar/gkad552
Structural insights into the DNA recognition
mechanism by the bacterial transcription factor PdxR
Ida Freda 1 , † , C ´ecile Exertier 2 , † , Anna Barile 2 , Antonio Chaves-Sanjuan 3 ,
Mirella... |
7ZTI | F61V Cytochrome c prime beta from Methylococcus capsulatus (Bath): CO Complex | A heme pocket aromatic quadrupole modulates gas binding
to cytochrome c0-β: Implications for NO sensors
Received for publication, January 24, 2023, and in revised form, April 15, 2023 Published, Papers in Press, April 24, 2023,
https://doi.org/10.1016/j.jbc.2023.104742
Hannah R. Adams1 , Dimitri A. Svistunenko1 , Micha... |
7ZTK | NME1 in complex with CoA | L IF E S CIEN CE S
Nucleoside diphosphate kinases 1 and 2 regulate a
protective liver response to a high-fat diet
Domenico Iuso1†, Isabel Garcia-Saez2, Yohann Couté3, Yoshiki Yamaryo-Botté1,
Elisabetta Boeri Erba2, Annie Adrait3, Nour Zeaiter4, Malgorzata Tokarska-Schlattner4,
Zuzana Macek Jilkova1,5, Fayçal Boussouar1... |
7ZTL | Crystal structure of a covalently linked Aurora-A N-Myc complex | research papers
Acta Cryst. (2023). D79, 1–9
https://doi.org/10.1107/S2059798322011433
1
Received 7 July 2022
Accepted 28 November 2022
Edited by M. Rudolph, F. Hoffmann-La Roche
Ltd, Switzerland
Keywords: Aurora-A; MYCN; cross-linking;
neuroblastoma cells; oncogenic transcription
factors; cancer targets.
PDB reference... |
7ZTS | Saccharomyces cerevisiae L-BC virus, open particle, asymmetric reconstruction | ARTICLE
Structures of L-BC virus and its open particle
provide insight into Totivirus capsid assembly
Danyil Grybchuk
1, Michaela Procházková1, Tibor Füzik
1, Aleksandras Konovalovas2, Saulius Serva
2,
Vyacheslav Yurchenko3 & Pavel Plevka
1✉
L-BC virus persists in the budding yeast Saccharomyces cerevisiae, whereas oth... |
7ZTV | Crystal structure of mutant AR-LBD (F755L) bound to dihydrotestosterone | BI O CHEM ISTRY
A hotspot for posttranslational modifications on the
androgen receptor dimer interface drives pathology
and anti-androgen resistance
Andrea Alegre-Martí1,2†, Alba Jiménez-Panizo1,2†, Adrián Martínez-Tébar3†, Coralie Poulard4,
M. Núria Peralta-Moreno5, Montserrat Abella1,2, Rosa Antón6, Marcos Chiñas3,7,... |
7ZTX | Crystal structure of mutant AR-LBD (F755V) bound to dihydrotestosterone | BI O CHEM ISTRY
A hotspot for posttranslational modifications on the
androgen receptor dimer interface drives pathology
and anti-androgen resistance
Andrea Alegre-Martí1,2†, Alba Jiménez-Panizo1,2†, Adrián Martínez-Tébar3†, Coralie Poulard4,
M. Núria Peralta-Moreno5, Montserrat Abella1,2, Rosa Antón6, Marcos Chiñas3,7,... |
7ZTY | Structure of Vps39 N-terminal domain from Chaetomium thermophilum | Shvarev, Schoppe, König et al. eLife 2022;11:e80901. DOI: https://doi.org/10.7554/eLife.80901
1 of 20
Structure of the HOPS tethering complex,
a lysosomal membrane fusion machinery
Dmitry Shvarev1†, Jannis Schoppe2†, Caroline König2†, Angela Perz2,
Nadia Füllbrunn2, Stephan Kiontke3, Lars Langemeyer2, Dovile Januli... |
7ZTZ | Crystal structure of mutant AR-LBD (Y764C) bound to dihydrotestosterone | BI O CHEM ISTRY
A hotspot for posttranslational modifications on the
androgen receptor dimer interface drives pathology
and anti-androgen resistance
Andrea Alegre-Martí1,2†, Alba Jiménez-Panizo1,2†, Adrián Martínez-Tébar3†, Coralie Poulard4,
M. Núria Peralta-Moreno5, Montserrat Abella1,2, Rosa Antón6, Marcos Chiñas3,7,... |
7ZU0 | HOPS tethering complex from yeast | Shvarev, Schoppe, König et al. eLife 2022;11:e80901. DOI: https://doi.org/10.7554/eLife.80901
1 of 20
Structure of the HOPS tethering complex,
a lysosomal membrane fusion machinery
Dmitry Shvarev1†, Jannis Schoppe2†, Caroline König2†, Angela Perz2,
Nadia Füllbrunn2, Stephan Kiontke3, Lars Langemeyer2, Dovile Januli... |
7ZU1 | Crystal structure of mutant AR-LBD (V758A) bound to dihydrotestosterone | BI O CHEM ISTRY
A hotspot for posttranslational modifications on the
androgen receptor dimer interface drives pathology
and anti-androgen resistance
Andrea Alegre-Martí1,2†, Alba Jiménez-Panizo1,2†, Adrián Martínez-Tébar3†, Coralie Poulard4,
M. Núria Peralta-Moreno5, Montserrat Abella1,2, Rosa Antón6, Marcos Chiñas3,7,... |
7ZU2 | Crystal structure of mutant AR-LBD (Q799E) bound to dihydrotestosterone | BI O CHEM ISTRY
A hotspot for posttranslational modifications on the
androgen receptor dimer interface drives pathology
and anti-androgen resistance
Andrea Alegre-Martí1,2†, Alba Jiménez-Panizo1,2†, Adrián Martínez-Tébar3†, Coralie Poulard4,
M. Núria Peralta-Moreno5, Montserrat Abella1,2, Rosa Antón6, Marcos Chiñas3,7,... |
7ZU8 | Crystal Structure of the zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 2.05 A resolution in presence of the crystallophore Lu-Xo4. | nature communications
Article
https://doi.org/10.1038/s41467-022-32215-1
Molecular and in vivo studies of a
glutamate-class prolyl-endopeptidase
for coeliac disease therapy
Laura del Amo-Maestro1,4, Soraia R. Mendes
1,4, Arturo Rodríguez-Banqueri1,
Laura Garzon-Flores
1, Marina Girbal2,3, María José Rodríguez-Lagunas
2... |
7ZU9 | CRYSTAL STRUCTURE OF THE C89A_C113A GMP SYNTHETASE INACTIVE DOUBLE MUTANT FROM PLASMODIUM FALCIPARUM | Citation: Ballut, L.; Violot, S.;
Galisson, F.; Gonçalves, I.R.; Martin,
J.; Shivakumaraswamy, S.; Carrique,
L.; Balaram, H.; Aghajari, N. Tertiary
and Quaternary Structure
Organization in GMP Synthetases:
Implications for Catalysis.
Biomolecules 2022, 12, 871.
https://doi.org/10.3390/
biom12070871
Academic Editor: Bea... |
7ZUB | Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex | Article
https://doi.org/10.1038/s41467-022-34773-w
Cryo-EM structure of the agonist-bound
Hsp90-XAP2-AHR cytosolic complex
Jakub Gruszczyk
1
, Loïc Grandvuillemin1, Josephine Lai-Kee-Him1,
Matteo Paloni
1, Christos G. Savva2, Pierre Germain1, Marina Grimaldi3,
Abdelhay Boulahtouf3, Hok-Sau Kwong1, Julien Bous
4, Auréli... |
7ZUF | Saccharomyces cerevisiae L-BC virus, open particle, C5 reconstruction | ARTICLE
Structures of L-BC virus and its open particle
provide insight into Totivirus capsid assembly
Danyil Grybchuk
1, Michaela Procházková1, Tibor Füzik
1, Aleksandras Konovalovas2, Saulius Serva
2,
Vyacheslav Yurchenko3 & Pavel Plevka
1✉
L-BC virus persists in the budding yeast Saccharomyces cerevisiae, whereas oth... |
7ZUH | PENICILLIN-BINDING PROTEIN 1B (PBP-1B) Streptococcus pneumoniae R6 | Combined Structural Analysis and Molecular Dynamics Reveal
Penicillin-Binding Protein Inhibition Mode with β-Lactones
Parker L. Flanders,
Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55454,
United States
Carlos Contreras-Martel,
Université Grenoble Alpes, CNRS, CEA, Institut de B... |
7ZUI | PENICILLIN-BINDING PROTEIN 1B (PBP-1B) in complex with lactone 5Az - Streptococcus pneumoniae R6 | Combined Structural Analysis and Molecular Dynamics Reveal
Penicillin-Binding Protein Inhibition Mode with β-Lactones
Parker L. Flanders,
Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55454,
United States
Carlos Contreras-Martel,
Université Grenoble Alpes, CNRS, CEA, Institut de B... |
7ZUJ | PENICILLIN-BINDING PROTEIN 1B (PBP-1B) in complex with lactone 6Az - Streptococcus pneumoniae R6 | Combined Structural Analysis and Molecular Dynamics Reveal
Penicillin-Binding Protein Inhibition Mode with β-Lactones
Parker L. Flanders,
Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55454,
United States
Carlos Contreras-Martel,
Université Grenoble Alpes, CNRS, CEA, Institut de B... |
7ZUK | PENICILLIN-BINDING PROTEIN 1B (PBP-1B) in complex with lactone 7Az - Streptococcus pneumoniae R6 | Combined Structural Analysis and Molecular Dynamics Reveal
Penicillin-Binding Protein Inhibition Mode with β-Lactones
Parker L. Flanders,
Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55454,
United States
Carlos Contreras-Martel,
Université Grenoble Alpes, CNRS, CEA, Institut de B... |
7ZUL | PENICILLIN-BINDING PROTEIN 1B (PBP-1B) in complex with 8Az lactone - Streptococcus pneumoniae R6 | Combined Structural Analysis and Molecular Dynamics Reveal
Penicillin-Binding Protein Inhibition Mode with β-Lactones
Parker L. Flanders,
Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55454,
United States
Carlos Contreras-Martel,
Université Grenoble Alpes, CNRS, CEA, Institut de B... |
7ZUP | Human PRMT5:MEP50 structure with Fragment (Example 18) and MTA Bound | RSC
Medicinal Chemistry
RESEARCH ARTICLE
Cite this: RSC Med. Chem., 2022, 13,
1549
Received 27th May 2022,
Accepted 27th August 2022
DOI: 10.1039/d2md00163b
rsc.li/medchem
Fragment optimization and elaboration strategies
– the discovery of two lead series of PRMT5/MTA
inhibitors from five fragment hits†
Christopher R. ... |
7ZUQ | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | RSC
Medicinal Chemistry
RESEARCH ARTICLE
Cite this: RSC Med. Chem., 2022, 13,
1549
Received 27th May 2022,
Accepted 27th August 2022
DOI: 10.1039/d2md00163b
rsc.li/medchem
Fragment optimization and elaboration strategies
– the discovery of two lead series of PRMT5/MTA
inhibitors from five fragment hits†
Christopher R. ... |
7ZUR | Four carbons pendant pyridine derivative of the natural alkaloid Berberine as Human Telomeric G-quadruplex Binder | Citation: Bazzicalupi, C.; Bonardi, A.;
Biver, T.; Ferraroni, M.; Papi, F.;
Savastano, M.; Lombardi, P.; Gratteri,
P. Probing the Efficiency of
13-Pyridylalkyl Berberine Derivatives
to Human Telomeric G-Quadruplexes
Binding: Spectroscopic, Solid State
and In Silico Analysis. Int. J. Mol. Sci.
2022, 23, 14061. https://do... |
7ZUU | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | RSC
Medicinal Chemistry
RESEARCH ARTICLE
Cite this: RSC Med. Chem., 2022, 13,
1549
Received 27th May 2022,
Accepted 27th August 2022
DOI: 10.1039/d2md00163b
rsc.li/medchem
Fragment optimization and elaboration strategies
– the discovery of two lead series of PRMT5/MTA
inhibitors from five fragment hits†
Christopher R. ... |
7ZUW | Structure of RQT (C1) bound to the stalled ribosome in a disome unit from S. cerevisiae | Article
https://doi.org/10.1038/s41467-023-36230-8
Structural basis for clearing of ribosome
collisions by the RQT complex
Katharina Best1, Ken Ikeuchi
1, Lukas Kater1,2, Daniel Best1, Joanna Musial1,
Yoshitaka Matsuo
3, Otto Berninghausen1, Thomas Becker1,
Toshifumi Inada3
& Roland Beckmann
1
Translation of aberrant m... |
7ZUX | Collided ribosome in a disome unit from S. cerevisiae | Article
https://doi.org/10.1038/s41467-023-36230-8
Structural basis for clearing of ribosome
collisions by the RQT complex
Katharina Best1, Ken Ikeuchi
1, Lukas Kater1,2, Daniel Best1, Joanna Musial1,
Yoshitaka Matsuo
3, Otto Berninghausen1, Thomas Becker1,
Toshifumi Inada3
& Roland Beckmann
1
Translation of aberrant m... |
7ZUY | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | RSC
Medicinal Chemistry
RESEARCH ARTICLE
Cite this: RSC Med. Chem., 2022, 13,
1549
Received 27th May 2022,
Accepted 27th August 2022
DOI: 10.1039/d2md00163b
rsc.li/medchem
Fragment optimization and elaboration strategies
– the discovery of two lead series of PRMT5/MTA
inhibitors from five fragment hits†
Christopher R. ... |
7ZV2 | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | RSC
Medicinal Chemistry
RESEARCH ARTICLE
Cite this: RSC Med. Chem., 2022, 13,
1549
Received 27th May 2022,
Accepted 27th August 2022
DOI: 10.1039/d2md00163b
rsc.li/medchem
Fragment optimization and elaboration strategies
– the discovery of two lead series of PRMT5/MTA
inhibitors from five fragment hits†
Christopher R. ... |
7ZV3 | Crystal structure of indoleamine 2,3-dioxygenase 1 (IDO1) in complex with ferric heme and MMG-0472 | RESEARCH PAPER
Structure-based optimization of type III indoleamine 2,3-dioxygenase 1
(IDO1) inhibitors
Ute F. R€ohriga†
, Somi Reddy Majjigapua,b†
, Pierre Vogelb
, Aline Reynaudc
, Florence Pojerc
,
Nahzli Dileka
, Patrick Reichenbachd, Kelly Ascenc¸~aoa
, Melita Irvingd
, George Coukosd
,
Olivier Michielina,e
and V... |
7ZV5 | Crystal structure of SARS Cov-2 main protease in complex with an inhibitor 4 |
Since January 2020 Elsevier has created a COVID-19 resource centre with
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19. The COVID-19 resource centre is hosted on Elsevier Connect, the
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Elsevier hereby grants permission to make all its C... |
7ZV7 | Crystal structure of SARS Cov-2 main protease in complex with an inhibitor 57 |
Since January 2020 Elsevier has created a COVID-19 resource centre with
free information in English and Mandarin on the novel coronavirus COVID-
19. The COVID-19 resource centre is hosted on Elsevier Connect, the
company's public news and information website.
Elsevier hereby grants permission to make all its C... |
7ZV8 | Crystal structure of SARS Cov-2 main protease in complex with an inhibitor 58 |
Since January 2020 Elsevier has created a COVID-19 resource centre with
free information in English and Mandarin on the novel coronavirus COVID-
19. The COVID-19 resource centre is hosted on Elsevier Connect, the
company's public news and information website.
Elsevier hereby grants permission to make all its C... |
7ZVA | Crystal Structure of the native zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 1.80 A resolution. | nature communications
Article
https://doi.org/10.1038/s41467-022-32215-1
Molecular and in vivo studies of a
glutamate-class prolyl-endopeptidase
for coeliac disease therapy
Laura del Amo-Maestro1,4, Soraia R. Mendes
1,4, Arturo Rodríguez-Banqueri1,
Laura Garzon-Flores
1, Marina Girbal2,3, María José Rodríguez-Lagunas
2... |
7ZVB | Crystal Structure of the mature form of the glutamic-class prolyl-endopeptidase neprosin at 2.35 A resolution. | nature communications
Article
https://doi.org/10.1038/s41467-022-32215-1
Molecular and in vivo studies of a
glutamate-class prolyl-endopeptidase
for coeliac disease therapy
Laura del Amo-Maestro1,4, Soraia R. Mendes
1,4, Arturo Rodríguez-Banqueri1,
Laura Garzon-Flores
1, Marina Girbal2,3, María José Rodríguez-Lagunas
2... |
7ZVC | Second crystal form of the mature glutamic-class prolyl-endopeptidase neprosin at 1.85 A resolution. | nature communications
Article
https://doi.org/10.1038/s41467-022-32215-1
Molecular and in vivo studies of a
glutamate-class prolyl-endopeptidase
for coeliac disease therapy
Laura del Amo-Maestro1,4, Soraia R. Mendes
1,4, Arturo Rodríguez-Banqueri1,
Laura Garzon-Flores
1, Marina Girbal2,3, María José Rodríguez-Lagunas
2... |
7ZVD | K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+ | Article
https://doi.org/10.1038/s41467-023-41895-2
Acetylation-dependent coupling between
G6PD activity and apoptotic signaling
Fang Wu1, Natali H. Muskat1, Inbar Dvilansky2, Omri Koren3, Anat Shahar4,
Roi Gazit
3,5, Natalie Elia2,5 & Eyal Arbely
1,2,5
Lysine acetylation has been discovered in thousands of non-histone ... |
7ZVE | K403 acetylated glucose-6-phosphate dehydrogenase (G6PD) | Article
https://doi.org/10.1038/s41467-023-41895-2
Acetylation-dependent coupling between
G6PD activity and apoptotic signaling
Fang Wu1, Natali H. Muskat1, Inbar Dvilansky2, Omri Koren3, Anat Shahar4,
Roi Gazit
3,5, Natalie Elia2,5 & Eyal Arbely
1,2,5
Lysine acetylation has been discovered in thousands of non-histone ... |
7ZVF | Crystal structure of human cathepsin L in complex with covalently bound CLIK148 | Structural Elucidation and Antiviral Activity of Covalent Cathepsin L
Inhibitors
Published as part of Journal of Medicinal Chemistry virtual special issue “Exploring Covalent Modulators in
Drug Discovery and Chemical Biology”.
Sven Falke,* Julia Lieske, Alexander Herrmann, Jure Loboda, Katarina Karničar, Sebastian Gü... |
7ZVI | Non-canonical Staphylococcus aureus pathogenicity island repression | Published online 6 October 2022
Nucleic Acids Research, 2022, Vol. 50, No. 19
11109–11127
https://doi.org/10.1093/nar/gkac855
Non-canonical Staphylococcus aureus pathogenicity
island repression
Laura Miguel-Romero1,2,†, Mohammed Alqasmi2,3,†, Julio Bacarizo1,4, Jason A. Tan5,
Richard J. Cogdell6, John Chen7, Olwyn Byro... |
7ZVJ | Homodimeric structure of LARGE1 | RESEARCH ARTICLE
Structural basis for matriglycan synthesis by
the LARGE1 dual glycosyltransferase
Michael Katz, Ron DiskinID*
Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel
* ron.diskin@weizmann.ac.il
Abstract
LARGE1 is a bifunctional glycosyltransferase responsible for g... |
7ZVL | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | RSC
Medicinal Chemistry
RESEARCH ARTICLE
Cite this: RSC Med. Chem., 2022, 13,
1549
Received 27th May 2022,
Accepted 27th August 2022
DOI: 10.1039/d2md00163b
rsc.li/medchem
Fragment optimization and elaboration strategies
– the discovery of two lead series of PRMT5/MTA
inhibitors from five fragment hits†
Christopher R. ... |
7ZVM | Thermococcus barophilus phosphomannose isomerase protein structure at 1.6 A |
Citation: Caliò, A.; Dubois, C.;
Fontanay, S.; Koza, M.M.; Hoh, F.;
Roumestand, C.; Oger, P.; Peters, J.
Unravelling the Adaptation
Mechanisms to High Pressure in
Proteins. Int. J. Mol. Sci. 2022, 23,
8469. https://doi.org/10.3390/
ijms23158469
Academic Editor: Istvan Simon
Received: 6 July 2022
Accep... |
7ZVN | Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution | Published online 17 September 2022
Nucleic Acids Research, 2023, Vol. 51, No. 3
1409–1423
https://doi.org/10.1093/nar/gkac774
Structures of annexin A2-PS DNA complexes show
dominance of hydrophobic interactions in
phosphorothioate binding
Malwina Hyjek-Składanowska1, Brooke A. Anderson2, Vitaliy Mykhaylyk3, Christian O... |
7ZVO | Structure of CBM BT0996-C from Bacteroides thetaiotaomicron | Journal of Structural Biology: X 7 (2023) 100084
Available online 2 January 2023
2590-1524/© 2022 Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
The structure of a Bacteroides thetaiotaomicron carbohydrate-binding
module provides new ins... |
7ZVP | Crystal structure of poplar glutathione transferase U19 in complex with glutathione | Biochemical and Structural Insights on
the Poplar Tau Glutathione
Transferase GSTU19 and 20 Paralogs
Binding Flavonoids
Elodie Sylvestre-Gonon 1, Laura Morette 1,2, Morgane Viloria 2, Sandrine Mathiot 2,
Alexis Boutilliat 1, Frédérique Favier 2, Nicolas Rouhier 1, Claude Didierjean 2* and
Arnaud Hecker 1*
1Université d... |
7ZVS | Crystal structure of the Schistosoma mansoni VKR2 kinase domain in an active-like state (ADP-bound) | Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase
Domain
Indran Mathavan,■Lawrence J. Liu,■Sean W. Robinson, Nelly El-Sakkary, Adam Jo J. Elatico,
Darwin Gomez, Ricky Nellas, Raymond J. Owens, William Zuercher, Iva Navratilova, Conor R. Caffrey,*
and Konstantinos Beis*
Cite This: ACS Med. Chem. Lett. ... |
7ZVT | CryoEM structure of Ku heterodimer bound to DNA | Nucleic Acids Research , 2023, 51 , 11732–11747
https://doi.org/10.1093/nar/gkad863
Advance access publication date: 23 October 2023
Genome integrity, repair and replication
Structural and functional basis of inositol hexaphosphate
stimulation of NHEJ through stabilization of Ku-XLF
int er action
Antonia Kefala ... |
7ZVU | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | RSC
Medicinal Chemistry
RESEARCH ARTICLE
Cite this: RSC Med. Chem., 2022, 13,
1549
Received 27th May 2022,
Accepted 27th August 2022
DOI: 10.1039/d2md00163b
rsc.li/medchem
Fragment optimization and elaboration strategies
– the discovery of two lead series of PRMT5/MTA
inhibitors from five fragment hits†
Christopher R. ... |
7ZVX | Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution | Published online 17 September 2022
Nucleic Acids Research, 2023, Vol. 51, No. 3
1409–1423
https://doi.org/10.1093/nar/gkac774
Structures of annexin A2-PS DNA complexes show
dominance of hydrophobic interactions in
phosphorothioate binding
Malwina Hyjek-Składanowska1, Brooke A. Anderson2, Vitaliy Mykhaylyk3, Christian O... |
7ZVY | Thermococcus kadokarensis phosphomannose isomerase |
Citation: Caliò, A.; Dubois, C.;
Fontanay, S.; Koza, M.M.; Hoh, F.;
Roumestand, C.; Oger, P.; Peters, J.
Unravelling the Adaptation
Mechanisms to High Pressure in
Proteins. Int. J. Mol. Sci. 2022, 23,
8469. https://doi.org/10.3390/
ijms23158469
Academic Editor: Istvan Simon
Received: 6 July 2022
Accep... |
7ZVZ | Cytochrome c prime beta from Methylococcus capsulatus (Bath): Chemically Reduced Ferrous Form | A heme pocket aromatic quadrupole modulates gas binding
to cytochrome c0-β: Implications for NO sensors
Received for publication, January 24, 2023, and in revised form, April 15, 2023 Published, Papers in Press, April 24, 2023,
https://doi.org/10.1016/j.jbc.2023.104742
Hannah R. Adams1 , Dimitri A. Svistunenko1 , Micha... |
7ZW1 | Human PRPH2-ROM1 hetero-dimer | El Mazouni and Gros, Sci. Adv. 8, eadd3677 (2022) 9 November 2022
SCIE N C E A D V A NCES | RESEA R CH A RT ICL E
1 of 8
ST RUCTURAL B IOL OG Y
Cryo-EM structures of peripherin-2 and ROM1
suggest multiple roles in photoreceptor
membrane morphogenesis
Dounia El Mazouni and Piet Gros*
Mammalian peripherin-2 (PRP... |
7ZW3 | Crystal Structure of human MAO B in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide (inhibitor 19) | ORIGINAL ARTICLE
8-Hydroxyquinolylnitrones as multifunctional
ligands for the therapy of neurodegenerative
diseases
Damijan Kneza,y, Daniel Diez-Iriepab,c,y, Mourad Chiouab,c,y,
Andrea Gottingerd, Milica Denice, Fabien Chantegreile,
Florian Nachone, Xavier Brazzolottoe, Anna Skrzypczak-Wierciochf,
Anze Medena, Anja Pi... |
7ZW6 | Oligomeric structure of SynDLP | Article
https://doi.org/10.1038/s41467-023-37746-9
SynDLP is a dynamin-like protein of Syne-
chocystis sp. PCC 6803 with eukaryotic
features
Lucas Gewehr1,8, Benedikt Junglas
2,3,8, Ruven Jilly1, Johannes Franz4,
Wenyu Eva Zhu1, Tobias Weidner
5, Mischa Bonn
4, Carsten Sachse
2,3,6
&
Dirk Schneider
1,7
Dynamin-like pro... |
7ZW9 | Crystal structure of a gamma-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei | Biochemical, structural, and computational studies of a c-carbonic
anhydrase from the pathogenic bacterium Burkholderia pseudomallei
Anna Di Fiore a,⇑, Viviana De Luca b, Emma Langella a, Alessio Nocentini c, Martina Buonanno a,
Simona Maria Monti a, Claudiu T. Supuran c, Clemente Capasso b, Giuseppina De Simone a,⇑
a ... |
7ZWA | CryoEM structure of Ku heterodimer bound to DNA and PAXX | ST RUCTURAL BIOLOGY
PAXX binding to the NHEJ machinery explains
functional redundancy with XLF
Murielle Seif-El-Dahan1†, Antonia Kefala-Stavridi2†‡, Philippe Frit3†, Steven W. Hardwick4†,
Dima Y. Chirgadze4, Taiana Maia De Oliviera5, Jessica Andreani1, Sébastien Britton3,
Nadia Barboule3, Madeleine Bossaert3, A... |
7ZWC | Structure of SNAPc:TBP-TFIIA-TFIIB sub-complex bound to U5 snRNA promoter | Nature Structural & Molecular Biology | Volume 29 | December 2022 | 1159–1169
1159
nature structural & molecular biology
https://doi.org/10.1038/s41594-022-00857-w
Article
Structural basis of SNAPc-dependent snRNA
transcription initiation by RNA polymerase II
Srinivasan Rengachari1, Sandra Schilbach
1, Thangavelu K... |
7ZWD | Structure of SNAPc containing Pol II pre-initiation complex bound to U5 snRNA promoter (CC) | Nature Structural & Molecular Biology | Volume 29 | December 2022 | 1159–1169
1159
nature structural & molecular biology
https://doi.org/10.1038/s41594-022-00857-w
Article
Structural basis of SNAPc-dependent snRNA
transcription initiation by RNA polymerase II
Srinivasan Rengachari1, Sandra Schilbach
1, Thangavelu K... |
7ZWE | The Crystal structure of GW8695 bound to CK2alpha | Nature Chemical Biology | Volume 20 | May 2024 | 577–585
577
nature chemical biology
https://doi.org/10.1038/s41589-023-01459-3
Article
Chemical proteomics reveals the target
landscape of 1,000 kinase inhibitors
Maria Reinecke1,2, Paul Brear
3, Larsen Vornholz
4,5,
Benedict-Tilmann Berger
6,7, Florian Seefri... |
7ZWF | Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3 | Article
https://doi.org/10.1038/s41467-022-33379-6
Structure of the malaria vaccine candidate
Pfs48/45 and its recognition by transmission
blocking antibodies
Kuang-Ting Ko1,2,6, Frank Lennartz1,6, David Mekhaiel
3,6, Bora Guloglu
1,2,
Arianna Marini3, Danielle J. Deuker3, Carole A. Long4, Matthijs M. Jore
5,
Kazutoyo ... |
7ZWG | The Crystal structure of RO4493940 bound to CK2alpha | Nature Chemical Biology | Volume 20 | May 2024 | 577–585
577
nature chemical biology
https://doi.org/10.1038/s41589-023-01459-3
Article
Chemical proteomics reveals the target
landscape of 1,000 kinase inhibitors
Maria Reinecke1,2, Paul Brear
3, Larsen Vornholz
4,5,
Benedict-Tilmann Berger
6,7, Florian Seefri... |
7ZWI | Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3 | Article
https://doi.org/10.1038/s41467-022-33379-6
Structure of the malaria vaccine candidate
Pfs48/45 and its recognition by transmission
blocking antibodies
Kuang-Ting Ko1,2,6, Frank Lennartz1,6, David Mekhaiel
3,6, Bora Guloglu
1,2,
Arianna Marini3, Danielle J. Deuker3, Carole A. Long4, Matthijs M. Jore
5,
Kazutoyo ... |
7ZWM | Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 | Article
https://doi.org/10.1038/s41467-022-33379-6
Structure of the malaria vaccine candidate
Pfs48/45 and its recognition by transmission
blocking antibodies
Kuang-Ting Ko1,2,6, Frank Lennartz1,6, David Mekhaiel
3,6, Bora Guloglu
1,2,
Arianna Marini3, Danielle J. Deuker3, Carole A. Long4, Matthijs M. Jore
5,
Kazutoyo ... |
7ZWN | Crystal structure of human BCL6 BTB domain in complex with a WVIP peptide | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWO | Crystal structure of human BCL6 BTB domain in complex with compound 2 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWP | Crystal structure of human BCL6 BTB domain in complex with compound 7 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWQ | Crystal structure of human BCL6 BTB domain in complex with compound 10 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWR | Crystal structure of human BCL6 BTB domain in complex with compound 11 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWS | Crystal structure of human BCL6 BTB domain in complex with compound 13 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWT | Crystal structure of human BCL6 BTB domain in complex with compound 14 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWU | Crystal structure of human BCL6 BTB domain in complex with compound 15 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWV | Crystal structure of human BCL6 BTB domain in complex with compound 17 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWW | Crystal structure of human BCL6 BTB domain in complex with compound 18 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
7ZWX | Crystal structure of human BCL6 BTB domain in complex with compound 19 | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:18633
| https://doi.org/10.1038/s41598-022-23264-z
www.nature.com/scientificreports
Discovering cell‑active BCL6
inhibitors: effectively combining
biochemical HTS with multiple
biophysical techniques, X‑ray
crystallography and cell‑based
assays
Olivier A.... |
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