protein_name stringlengths 4 4 | structure_title stringlengths 3 322 | main_text stringlengths 0 302k |
|---|---|---|
7Z6H | Structure of DNA-bound human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp | Published online 12 July 2022
Nucleic Acids Research, 2022, Vol. 50, No. 14
8279–8289
https://doi.org/10.1093/nar/gkac588
Structure of the human RAD17–RFC clamp loader and
9–1–1 checkpoint clamp bound to a dsDNA–ssDNA
junction
Matthew Day
1,*, Antony W. Oliver
1 and Laurence H. Pearl
1,2,*
1Cancer Research UK DNA Repai... |
7Z6I | Crystal structure of p38alpha C162S in complex with SB20358 and CAS 2094667-81-7 (behind catalytic site; Y35 in), P 21 21 21 | Article
https://doi.org/10.1038/s41467-023-39051-x
Characterization of p38α
autophosphorylation inhibitors that target
the non-canonical activation pathway
Lorena González1, Lucía Díaz
2, Joan Pous
1, Blazej Baginski
1,
Anna Duran-Corbera1, Margherita Scarpa1, Isabelle Brun-Heath
1, Ana Igea1,
Pau Martin-Malpartida
1, ... |
7Z6K | CRYSTAL STRUCTURE OF WEISSELLA VIRIDESCENS FEMXVV NON-RIBOSOMAL AMINO ACID TRANSFERASE IN COMPLEX WITH A PEPTIDYL-XNA CONJUGATE | Published online 9 November 2022
Nucleic Acids Research, 2022, Vol. 50, No. 20
11415–11425
https://doi.org/10.1093/nar/gkac1023
Amino-acyl tXNA as inhibitors or amino acid donors in
peptide synthesis
Lauriane Rietmeyer
1,†, In`es Li De La Sierra-Gallay
2,†, Guy Schepers3,
Delphine Dorchˆene1, Laura Iannazzo4, Delphine ... |
7Z6L | Crystal structure of PROTAC 5 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Article
https://doi.org/10.1038/s41467-022-33430-6
A selective and orally bioavailable VHL-
recruiting PROTAC achieves SMARCA2
degradation in vivo
A list of authors and their affiliations appears at the end of the paper
A list of authors and their affiliations appears at the end of the paper
Targeted protein degradation ... |
7Z6M | Crystal structure of Zn2+-transporter BbZIP in a cadmium bound state | Wiuf et al., Sci. Adv. 8, eabn4331 (2022) 13 July 2022
SCIE N C E A D V A NCES | RESEA R CH A RT ICL E
1 of 13
ST RUCTURAL B IOL OG Y
The two-domain elevator-type mechanism of
zinc-transporting ZIP proteins
Anders Wiuf1, Jonas Hyld Steffen1, Eva Ramos Becares1, Christina Grønberg1, Dhani Ram Mahato2,
Søren G. F... |
7Z6N | Crystal structure of Zn2+-transporter BbZIP in a metal-stripped state | Wiuf et al., Sci. Adv. 8, eabn4331 (2022) 13 July 2022
SCIE N C E A D V A NCES | RESEA R CH A RT ICL E
1 of 13
ST RUCTURAL B IOL OG Y
The two-domain elevator-type mechanism of
zinc-transporting ZIP proteins
Anders Wiuf1, Jonas Hyld Steffen1, Eva Ramos Becares1, Christina Grønberg1, Dhani Ram Mahato2,
Søren G. F... |
7Z6O | X-Ray studies of Ku70/80 reveal the binding site for IP6 | Nucleic Acids Research , 2023, 51 , 11732–11747
https://doi.org/10.1093/nar/gkad863
Advance access publication date: 23 October 2023
Genome integrity, repair and replication
Structural and functional basis of inositol hexaphosphate
stimulation of NHEJ through stabilization of Ku-XLF
int er action
Antonia Kefala ... |
7Z6Q | Cryo-EM structure of the whole photosynthetic complex from the green sulfur bacteria | PNAS 2023 Vol. 120 No. 5 e2216734120
https://doi.org/10.1073/pnas.2216734120 1 of 11
RESEARCH ARTICLE |
Significance
Photosynthesis is the
fundamental process that
maintains life on Earth. The
photosynthetic apparatus of
green sulfur bacteria exhibits an
unusual organization of their
intermediate light-ha... |
7Z6R | Psychrobacter arcticus ATPPRT (HisGZ) R56A mutant bound to ATP and PRPP | Article
https://doi.org/10.1038/s41467-022-34960-9
Allosteric rescue of catalytically impaired
ATP phosphoribosyltransferase variants
links protein dynamics to active-site
electrostatic preorganisation
Gemma Fisher1, Marina Corbella
2, Magnus S. Alphey1, John Nicholson1,
Benjamin J. Read1, Shina C. L. Kamerlin
2,3
& Ra... |
7Z6V | CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11 nanobody complex | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z6W | Complex of E. coli LolA and lipoprotein | Structural basis of lipoprotein recognition by the bacterial Lol
trafficking chaperone LolA
Elise Kaplana,1
, Nicholas P. Greenea,1,2
, Abigail E. Jepsona
, and Vassilis Koronakisa,2
Edited by Thomas Silhavy, Princeton University, Princeton, NJ; received May 19, 2022; accepted July 13, 2022
In gram-negative bacteria, li... |
7Z6X | Complex of E. coli LolA R43L mutant and lipoprotein | Structural basis of lipoprotein recognition by the bacterial Lol
trafficking chaperone LolA
Elise Kaplana,1
, Nicholas P. Greenea,1,2
, Abigail E. Jepsona
, and Vassilis Koronakisa,2
Edited by Thomas Silhavy, Princeton University, Princeton, NJ; received May 19, 2022; accepted July 13, 2022
In gram-negative bacteria, li... |
7Z6Z | Crystal structure of Angiotensin-1 converting enzyme N-domain in complex with fosinoprilat | Structural basis for the inhibition of human angiotensin-1
converting enzyme by fosinoprilat
Gyles E. Cozier1, Emma C. Newby1, Sylva L. U. Schwager2, R. Elwyn Isaac3, Edward D. Sturrock2
and K. Ravi Acharya1
1 Department of Biology and Biochemistry, University of Bath, UK
2 Department of Integrative Biomedical Sciences... |
7Z70 | Crystal structure of Angiotensin-1 converting enzyme C-domain in complex with fosinoprilat | Structural basis for the inhibition of human angiotensin-1
converting enzyme by fosinoprilat
Gyles E. Cozier1, Emma C. Newby1, Sylva L. U. Schwager2, R. Elwyn Isaac3, Edward D. Sturrock2
and K. Ravi Acharya1
1 Department of Biology and Biochemistry, University of Bath, UK
2 Department of Integrative Biomedical Sciences... |
7Z71 | Crystal structure of p63 DBD in complex with darpin C14 | ARTICLE
OPEN
Designed Ankyrin Repeat Proteins as a tool box for
analyzing p63
Alexander Strubel
1,5, Philipp Münick
1,5, Apirat Chaikuad2,3, Birgit Dreier4, Jonas Schaefer4, Jakob Gebel1, Christian Osterburg
1,
Marcel Tuppi1, Birgit Schäfer1, Stefan Knapp
2,3, Andreas Plückthun
4 and Volker Dötsch
1✉
© The Author(s) 20... |
7Z72 | Crystal structure of p63 SAM in complex with darpin A5 | ARTICLE
OPEN
Designed Ankyrin Repeat Proteins as a tool box for
analyzing p63
Alexander Strubel
1,5, Philipp Münick
1,5, Apirat Chaikuad2,3, Birgit Dreier4, Jonas Schaefer4, Jakob Gebel1, Christian Osterburg
1,
Marcel Tuppi1, Birgit Schäfer1, Stefan Knapp
2,3, Andreas Plückthun
4 and Volker Dötsch
1✉
© The Author(s) 20... |
7Z73 | Crystal structure of p63 tetramerization domain in complex with darpin 8F1 | ARTICLE
OPEN
Designed Ankyrin Repeat Proteins as a tool box for
analyzing p63
Alexander Strubel
1,5, Philipp Münick
1,5, Apirat Chaikuad2,3, Birgit Dreier4, Jonas Schaefer4, Jakob Gebel1, Christian Osterburg
1,
Marcel Tuppi1, Birgit Schäfer1, Stefan Knapp
2,3, Andreas Plückthun
4 and Volker Dötsch
1✉
© The Author(s) 20... |
7Z74 | PI3KC2a core in complex with PITCOIN2 | Articles
https://doi.org/10.1038/s41589-022-01118-z
1Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. 2Max-Delbrück-Centrum für Molekulare Medizin, Kristallographie,
Berlin, Germany. 3Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany. 4MRC Laboratory... |
7Z75 | PI3KC2a core in complex with PITCOIN3 | Articles
https://doi.org/10.1038/s41589-022-01118-z
1Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. 2Max-Delbrück-Centrum für Molekulare Medizin, Kristallographie,
Berlin, Germany. 3Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany. 4MRC Laboratory... |
7Z76 | Crystal structure of compound 10 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Article
https://doi.org/10.1038/s41467-022-33430-6
A selective and orally bioavailable VHL-
recruiting PROTAC achieves SMARCA2
degradation in vivo
A list of authors and their affiliations appears at the end of the paper
A list of authors and their affiliations appears at the end of the paper
Targeted protein degradation ... |
7Z77 | Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Article
https://doi.org/10.1038/s41467-022-33430-6
A selective and orally bioavailable VHL-
recruiting PROTAC achieves SMARCA2
degradation in vivo
A list of authors and their affiliations appears at the end of the paper
A list of authors and their affiliations appears at the end of the paper
Targeted protein degradation ... |
7Z78 | Crystal structure of compound 4 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Article
https://doi.org/10.1038/s41467-022-33430-6
A selective and orally bioavailable VHL-
recruiting PROTAC achieves SMARCA2
degradation in vivo
A list of authors and their affiliations appears at the end of the paper
A list of authors and their affiliations appears at the end of the paper
Targeted protein degradation ... |
7Z7B | Crystal structure of YTHDF2 with compound YLI_DC1_003 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
Read Online
ACCESS
Metrics & More
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*
sı
Supporting Information
ABSTRACT: We report 17 small-molecule ... |
7Z7C | Broadly neutralizing DARPin bnD.8 in complex with the HIV-1 envelope variable loop 3 peptide V3 (BF520) | Nature Structural & Molecular Biology | Volume 30 | September 2023 | 1323–1336
1323
nature structural & molecular biology
https://doi.org/10.1038/s41594-023-01062-z
Article
Trapping the HIV-1 V3 loop in a helical
conformation enables broad neutralization
Matthias Glögl
1, Nikolas Friedrich
1,7, Gabriele Cerutti ... |
7Z7D | Tubulin-Todalam-Vinblastine-complex | Drug Design Hot Paper
Rational Design of a Novel Tubulin Inhibitor with a Unique
Mechanism of Action
Tobias Mühlethaler+, Lampros Milanos+,* Jose Antonio Ortega, Thorsten B. Blum,
Dario Gioia, Bibhas Roy, Andrea E. Prota, Andrea Cavalli,* and Michel O. Steinmetz*
Abstract: In this study, we capitalized on our previousl... |
7Z7E | Crystal structure of p63 DNA binding domain in complex with inhibitory DARPin G4 | ARTICLE
OPEN
Designed Ankyrin Repeat Proteins as a tool box for
analyzing p63
Alexander Strubel
1,5, Philipp Münick
1,5, Apirat Chaikuad2,3, Birgit Dreier4, Jonas Schaefer4, Jakob Gebel1, Christian Osterburg
1,
Marcel Tuppi1, Birgit Schäfer1, Stefan Knapp
2,3, Andreas Plückthun
4 and Volker Dötsch
1✉
© The Author(s) 20... |
7Z7F | Crystal structure of YTHDF2 with compound YLI_DC1_005 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
Read Online
ACCESS
Metrics & More
Article Recommendations
*
sı
Supporting Information
ABSTRACT: We report 17 small-molecule ... |
7Z7H | Structure of P. luminescens TccC3-F-actin complex | ARTICLE
Mechanism of threonine ADP-ribosylation of
F-actin by a Tc toxin
Alexander Belyy
1,6, Florian Lindemann
2,6, Daniel Roderer
1,5, Johanna Funk3, Benjamin Bardiaux
4,
Jonas Protze
2, Peter Bieling
3, Hartmut Oschkinat
2,7✉& Stefan Raunser
1,7✉
Tc toxins deliver toxic enzymes into host cells by a unique injection ... |
7Z7I | Structure of ADP-ribosylated F-actin | ARTICLE
Mechanism of threonine ADP-ribosylation of
F-actin by a Tc toxin
Alexander Belyy
1,6, Florian Lindemann
2,6, Daniel Roderer
1,5, Johanna Funk3, Benjamin Bardiaux
4,
Jonas Protze
2, Peter Bieling
3, Hartmut Oschkinat
2,7✉& Stefan Raunser
1,7✉
Tc toxins deliver toxic enzymes into host cells by a unique injection ... |
7Z7K | REP-related Chom18 variant with double AT base pairing | research papers
Acta Cryst. (2023). D79, 655–665
https://doi.org/10.1107/S2059798323004679
655
Received 22 December 2022
Accepted 26 May 2023
Edited by R. J. Read, University of Cambridge,
United Kingdom
Keywords: DNA structure; dnatco.datmos.org;
structure validation; structure refinement; base
pairing.
PDB references... |
7Z7L | REP-related Chom18 variant with double AC mismatch | research papers
Acta Cryst. (2023). D79, 655–665
https://doi.org/10.1107/S2059798323004679
655
Received 22 December 2022
Accepted 26 May 2023
Edited by R. J. Read, University of Cambridge,
United Kingdom
Keywords: DNA structure; dnatco.datmos.org;
structure validation; structure refinement; base
pairing.
PDB references... |
7Z7M | REP-related Chom18 variant with double CC mismatch | research papers
Acta Cryst. (2023). D79, 655–665
https://doi.org/10.1107/S2059798323004679
655
Received 22 December 2022
Accepted 26 May 2023
Edited by R. J. Read, University of Cambridge,
United Kingdom
Keywords: DNA structure; dnatco.datmos.org;
structure validation; structure refinement; base
pairing.
PDB references... |
7Z7N | Mot1E1434Q:TBP:DNA - substrate recognition state | Structural basis for TBP displacement from TATA box DNA by
the Swi2/Snf2 ATPase Mot1
Stephan Woike1,2, Sebastian Eustermann#1,2,3, James Jung#1,2, Simon Josef Wenzl1,2, Götz
Hagemann1,2, Joseph Bartho1,2, Katja Lammens1,2, Agata Butryn1,2,4, Franz Herzog2,5,
Karl-Peter Hopfner1,2,*
1Department of Biochemistry, Ludwi... |
7Z7O | Structure of the fluorescent protein NeonCyan0.95 at pH 7.5 | Received: November 22, 2021. Revised: March 17, 2022. Accepted: April 5, 2022
© The Author(s) 2022. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which
permits unrestricted reuse... |
7Z7P | Structure of the fluorescent protein NeonCyan0.95 at pH 5.6 | Received: November 22, 2021. Revised: March 17, 2022. Accepted: April 5, 2022
© The Author(s) 2022. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which
permits unrestricted reuse... |
7Z7Q | Structure of the T207D single-point mutant of the fluorescent protein NeonCyan1 at pH 6.5 | Received: November 22, 2021. Revised: March 17, 2022. Accepted: April 5, 2022
© The Author(s) 2022. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which
permits unrestricted reuse... |
7Z7U | REP-related Chom18 variant with double CG base pair | research papers
Acta Cryst. (2023). D79, 655–665
https://doi.org/10.1107/S2059798323004679
655
Received 22 December 2022
Accepted 26 May 2023
Edited by R. J. Read, University of Cambridge,
United Kingdom
Keywords: DNA structure; dnatco.datmos.org;
structure validation; structure refinement; base
pairing.
PDB references... |
7Z7W | REP-related Chom18 variant with double GC base pairing | research papers
Acta Cryst. (2023). D79, 655–665
https://doi.org/10.1107/S2059798323004679
655
Received 22 December 2022
Accepted 26 May 2023
Edited by R. J. Read, University of Cambridge,
United Kingdom
Keywords: DNA structure; dnatco.datmos.org;
structure validation; structure refinement; base
pairing.
PDB references... |
7Z7X | CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H6 nanobody complex | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z7Y | REP-related Chom18 variant with double GT mismatch | research papers
Acta Cryst. (2023). D79, 655–665
https://doi.org/10.1107/S2059798323004679
655
Received 22 December 2022
Accepted 26 May 2023
Edited by R. J. Read, University of Cambridge,
United Kingdom
Keywords: DNA structure; dnatco.datmos.org;
structure validation; structure refinement; base
pairing.
PDB references... |
7Z7Z | REP-related Chom18 variant with double TA base pair | research papers
Acta Cryst. (2023). D79, 655–665
https://doi.org/10.1107/S2059798323004679
655
Received 22 December 2022
Accepted 26 May 2023
Edited by R. J. Read, University of Cambridge,
United Kingdom
Keywords: DNA structure; dnatco.datmos.org;
structure validation; structure refinement; base
pairing.
PDB references... |
7Z81 | REP-related Chom18 variant with double TC mismatch | research papers
Acta Cryst. (2023). D79, 655–665
https://doi.org/10.1107/S2059798323004679
655
Received 22 December 2022
Accepted 26 May 2023
Edited by R. J. Read, University of Cambridge,
United Kingdom
Keywords: DNA structure; dnatco.datmos.org;
structure validation; structure refinement; base
pairing.
PDB references... |
7Z82 | REP-related Chom18 variant with double AG mismatch | research papers
Acta Cryst. (2023). D79, 655–665
https://doi.org/10.1107/S2059798323004679
655
Received 22 December 2022
Accepted 26 May 2023
Edited by R. J. Read, University of Cambridge,
United Kingdom
Keywords: DNA structure; dnatco.datmos.org;
structure validation; structure refinement; base
pairing.
PDB references... |
7Z85 | CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-B5 nanobody complex | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z86 | CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 1Up2Down conformation | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z87 | DNA-PK in the active state | Nature Structural & Molecular Biology | Volume 30 | February 2023 | 140–147
140
nature structural & molecular biology
Article
https://doi.org/10.1038/s41594-022-00881-w
Human DNA-dependent protein kinase
activation mechanism
Shikang Liang
1,2
& Tom L. Blundell
1,2
DNA-dependent protein kinase (DNA-PK), a mult... |
7Z88 | DNA-PK in the intermediate state | Nature Structural & Molecular Biology | Volume 30 | February 2023 | 140–147
140
nature structural & molecular biology
Article
https://doi.org/10.1038/s41594-022-00881-w
Human DNA-dependent protein kinase
activation mechanism
Shikang Liang
1,2
& Tom L. Blundell
1,2
DNA-dependent protein kinase (DNA-PK), a mult... |
7Z89 | Sam68 | F U L L - L E N G T H P A P E R
Structure and function analysis of Sam68 and hnRNP A1
synergy in the exclusion of exon 7 from SMN2 transcripts
Marta Nadal1
|
Rosa Anton1
|
Jonatan Dorca-Arévalo1
|
Eva Estébanez-Perpiña2
|
Eduardo F. Tizzano3,4
|
Pablo Fuentes-Prior1
1Molecular Bases of Disease, Biomedical
Research Ins... |
7Z8A | Sam68 | F U L L - L E N G T H P A P E R
Structure and function analysis of Sam68 and hnRNP A1
synergy in the exclusion of exon 7 from SMN2 transcripts
Marta Nadal1
|
Rosa Anton1
|
Jonatan Dorca-Arévalo1
|
Eva Estébanez-Perpiña2
|
Eduardo F. Tizzano3,4
|
Pablo Fuentes-Prior1
1Molecular Bases of Disease, Biomedical
Research Ins... |
7Z8B | Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation | Articles
https://doi.org/10.1038/s41594-022-00815-6
1Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany. 2Department of Biochemistry and
Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 3Presen... |
7Z8E | Crystal structure of the substrate-binding protein YejA from S. meliloti in complex with peptide fragment | Dual-Uptake Mode of the Antibiotic Phazolicin Prevents
Resistance Acquisition by Gram-Negative Bacteria
Dmitrii Y. Travin,a,b Romain Jouan,c Armelle Vigouroux,c Satomi Inaba-Inoue,d,e Joy Lachat,c* Fazal Haq,c Tatiana Timchenko,c
Dmitry Sutormin,a,b Svetlana Dubiley,a,b§ Konstantinos Beis,d,e Solange Moréra,c Konstanti... |
7Z8F | Composite structure of dynein-dynactin-BICDR on microtubules | Structure of dynein-dynactin on microtubules shows tandem
adaptor binding
Sami Chaaban,
Andrew P. Carter*
Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Francis
Crick Avenue, Cambridge, CB2 0QH, UK
Summary Paragraph
Cytoplasmic dynein is a microtubule motor that is activated... |
7Z8G | Cytoplasmic dynein-1 motor domain | Structure of dynein-dynactin on microtubules shows tandem
adaptor binding
Sami Chaaban,
Andrew P. Carter*
Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Francis
Crick Avenue, Cambridge, CB2 0QH, UK
Summary Paragraph
Cytoplasmic dynein is a microtubule motor that is activated... |
7Z8H | Cytoplasmic dynein-1 motor domain AAA1, AAA2, and AAA3 subunits | Structure of dynein-dynactin on microtubules shows tandem
adaptor binding
Sami Chaaban,
Andrew P. Carter*
Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Francis
Crick Avenue, Cambridge, CB2 0QH, UK
Summary Paragraph
Cytoplasmic dynein is a microtubule motor that is activated... |
7Z8I | The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2) | Structure of dynein-dynactin on microtubules shows tandem
adaptor binding
Sami Chaaban,
Andrew P. Carter*
Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Francis
Crick Avenue, Cambridge, CB2 0QH, UK
Summary Paragraph
Cytoplasmic dynein is a microtubule motor that is activated... |
7Z8J | Cytoplasmic dynein (A2) bound to BICDR1 | Structure of dynein-dynactin on microtubules shows tandem
adaptor binding
Sami Chaaban,
Andrew P. Carter*
Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Francis
Crick Avenue, Cambridge, CB2 0QH, UK
Summary Paragraph
Cytoplasmic dynein is a microtubule motor that is activated... |
7Z8K | Cytoplasmic dynein (A1) bound to BICDR1 | Structure of dynein-dynactin on microtubules shows tandem
adaptor binding
Sami Chaaban,
Andrew P. Carter*
Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Francis
Crick Avenue, Cambridge, CB2 0QH, UK
Summary Paragraph
Cytoplasmic dynein is a microtubule motor that is activated... |
7Z8L | Cytoplasmic dynein light intermediate chain (B1) bound to the motor domain (A2). | Structure of dynein-dynactin on microtubules shows tandem
adaptor binding
Sami Chaaban,
Andrew P. Carter*
Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Francis
Crick Avenue, Cambridge, CB2 0QH, UK
Summary Paragraph
Cytoplasmic dynein is a microtubule motor that is activated... |
7Z8M | The pointed end complex of dynactin bound to BICDR1 | Structure of dynein-dynactin on microtubules shows tandem
adaptor binding
Sami Chaaban,
Andrew P. Carter*
Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Francis
Crick Avenue, Cambridge, CB2 0QH, UK
Summary Paragraph
Cytoplasmic dynein is a microtubule motor that is activated... |
7Z8O | Crystal structure of SARS-CoV-2 S RBD in complex with a stapled peptide | Article
https://doi.org/10.1038/s41467-023-39158-1
Multivalent bicyclic peptides are an effective
antiviral modality that can potently inhibit
SARS-CoV-2
Katherine U. Gaynor
1,6, Marina Vaysburd2,6, Maximilian A. J. Harman
1,
Anna Albecka2, Phillip Jeffrey1, Paul Beswick1, Guido Papa
2, Liuhong Chen
1,
Donna Mallery
2,... |
7Z8P | Crystal structure of YTHDF2 with compound ZA_166 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
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ABSTRACT: We report 17 small-molecule ... |
7Z8S | Mot1:TBP:DNA - post hydrolysis state | Structural basis for TBP displacement from TATA box DNA by
the Swi2/Snf2 ATPase Mot1
Stephan Woike1,2, Sebastian Eustermann#1,2,3, James Jung#1,2, Simon Josef Wenzl1,2, Götz
Hagemann1,2, Joseph Bartho1,2, Katja Lammens1,2, Agata Butryn1,2,4, Franz Herzog2,5,
Karl-Peter Hopfner1,2,*
1Department of Biochemistry, Ludwi... |
7Z8U | Catalytic subunit HisG R56A mutant from Psychrobacter arcticus ATPPRT (HisGZ) in complex with ATP and PRPP | Article
https://doi.org/10.1038/s41467-022-34960-9
Allosteric rescue of catalytically impaired
ATP phosphoribosyltransferase variants
links protein dynamics to active-site
electrostatic preorganisation
Gemma Fisher1, Marina Corbella
2, Magnus S. Alphey1, John Nicholson1,
Benjamin J. Read1, Shina C. L. Kamerlin
2,3
& Ra... |
7Z8W | Crystal structure of YTHDF2 with compound YLI_DC1_018 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
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ABSTRACT: We report 17 small-molecule ... |
7Z8X | Crystal structure of YTHDF2 with compound YLI_DC1_017 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
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ABSTRACT: We report 17 small-molecule ... |
7Z8Y | Crystal structure of the SUN1-KASH6 9:6 complex | ARTICLE
The crystal structure of SUN1-KASH6 reveals an
asymmetric LINC complex architecture compatible
with nuclear membrane insertion
Manickam Gurusaran1, Benedikte S. Erlandsen1 & Owen R. Davies
1✉
The LINC complex transmits cytoskeletal forces into the nucleus to control the structure and
movement of nuclear content... |
7Z8Z | Crystal structure of the MEILB2-BRME1 2:2 core complex | Article
https://doi.org/10.1038/s41467-024-50920-x
MEILB2-BRME1 forms a V-shaped DNA clamp
upon BRCA2-binding in meiotic
recombination
Manickam Gurusaran
1, Jingjing Zhang2, Kexin Zhang2, Hiroki Shibuya
2,3 &
Owen R. Davies
1
DNA double-strand break repair by homologous recombination has a specia-
lised role in meiosis... |
7Z92 | Crystal structure of YTHDF2 with compound YLI_DF_024 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
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ABSTRACT: We report 17 small-molecule ... |
7Z93 | Crystal structure of YTHDF2 with compound YLI_DF_022 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
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ABSTRACT: We report 17 small-molecule ... |
7Z9A | Sam68 | F U L L - L E N G T H P A P E R
Structure and function analysis of Sam68 and hnRNP A1
synergy in the exclusion of exon 7 from SMN2 transcripts
Marta Nadal1
|
Rosa Anton1
|
Jonatan Dorca-Arévalo1
|
Eva Estébanez-Perpiña2
|
Eduardo F. Tizzano3,4
|
Pablo Fuentes-Prior1
1Molecular Bases of Disease, Biomedical
Research Ins... |
7Z9B | Sam68 | F U L L - L E N G T H P A P E R
Structure and function analysis of Sam68 and hnRNP A1
synergy in the exclusion of exon 7 from SMN2 transcripts
Marta Nadal1
|
Rosa Anton1
|
Jonatan Dorca-Arévalo1
|
Eva Estébanez-Perpiña2
|
Eduardo F. Tizzano3,4
|
Pablo Fuentes-Prior1
1Molecular Bases of Disease, Biomedical
Research Ins... |
7Z9C | E.coli gyrase holocomplex with 217 bp DNA and albicidin | Nature Catalysis | Volume 6 | January 2023 | 52–67
52
nature catalysis
Article
https://doi.org/10.1038/s41929-022-00904-1
Molecular mechanism of topoisomerase
poisoning by the peptide antibiotic albicidin
Elizabeth Michalczyk
1,7, Kay Hommernick
2,7, Iraj Behroz2, Marcel Kulike2,
Zuzanna Pakosz-Stępień
1,3, ... |
7Z9F | Human anionic trypsin after autoproteolysis at Arg122 | O R I G I N A L R E S E A R C H
Structural Basis of the Pancreatitis-Associated
Autoproteolytic Failsafe Mechanism in Human
Anionic Trypsin
Felix Nagel
1, Anne Susemihl
1,2, Norman Geist
1, Kevin Möhlis1,3, Gottfried J Palm
4,
Michael Lammers4, Mihaela Delcea
1
1Biophysical Chemistry, Institute of Biochemistry, Univers... |
7Z9G | E.coli gyrase holocomplex with 217 bp DNA and Albi-2 | Nature Catalysis | Volume 6 | January 2023 | 52–67
52
nature catalysis
Article
https://doi.org/10.1038/s41929-022-00904-1
Molecular mechanism of topoisomerase
poisoning by the peptide antibiotic albicidin
Elizabeth Michalczyk
1,7, Kay Hommernick
2,7, Iraj Behroz2, Marcel Kulike2,
Zuzanna Pakosz-Stępień
1,3, ... |
7Z9H | ATAD2 in complex with PepLite-Asp | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7Z9I | ATAD2 in complex with PepLite-Ala | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7Z9J | ATAD2 in complex with PepLite-Gly | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7Z9K | E.coli gyrase holocomplex with 217 bp DNA and Albi-1 (site TG) | Nature Catalysis | Volume 6 | January 2023 | 52–67
52
nature catalysis
Article
https://doi.org/10.1038/s41929-022-00904-1
Molecular mechanism of topoisomerase
poisoning by the peptide antibiotic albicidin
Elizabeth Michalczyk
1,7, Kay Hommernick
2,7, Iraj Behroz2, Marcel Kulike2,
Zuzanna Pakosz-Stępień
1,3, ... |
7Z9L | Phen-DC3 intercalation causes hybrid-to-antiparallel transformation of human telomeric DNA G-quadruplex | G-Quadruplex
Phen-DC3 Induces Refolding of Human Telomeric DNA into a
Chair-Type Antiparallel G-Quadruplex through Ligand Intercalation
Anirban Ghosh, Marko Trajkovski, Marie-Paule Teulade-Fichou, Valérie Gabelica,* and
Janez Plavec*
Abstract: Human telomeric G-quadruplex DNA structures are attractive anticancer drug t... |
7Z9M | E.coli gyrase holocomplex with 217 bp DNA and Albi-1 (site AA) | Nature Catalysis | Volume 6 | January 2023 | 52–67
52
nature catalysis
Article
https://doi.org/10.1038/s41929-022-00904-1
Molecular mechanism of topoisomerase
poisoning by the peptide antibiotic albicidin
Elizabeth Michalczyk
1,7, Kay Hommernick
2,7, Iraj Behroz2, Marcel Kulike2,
Zuzanna Pakosz-Stępień
1,3, ... |
7Z9N | ATAD2 in complex with PepLite-Val | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7Z9O | ATAD2 in complex with PepLite-Tyr | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7Z9P | The novel DNA binding mechanism of ridinilazole, a precision Clostridiodes difficile antibiotic | The Novel DNA Binding Mechanism of Ridinilazole, a Precision
Clostridiodes difficile Antibiotic
Clive S. Mason,a Tim Avis,a Chenlin Hu,b Nabeetha Nagalingam,a Manikhandan Mudaliar,a Chris Coward,a Khurshida Begum,b
Kathleen Gajewski,c M. Jahangir Alam,b Eugenie Bassères,b Stephen Moss,d Stefanie Reich,d Esther Duperchy,... |
7Z9Q | CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-A10 nanobody complex | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z9R | CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 2Up1Down conformation | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z9S | ATAD2 in complex with PepLite-Arg | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7Z9T | Crystal structure of p38alpha C162S in complex with ATPgS and CAS 2094667-81-7 (in catalytic site, Y35 out), P 1 21 1 | Article
https://doi.org/10.1038/s41467-023-39051-x
Characterization of p38α
autophosphorylation inhibitors that target
the non-canonical activation pathway
Lorena González1, Lucía Díaz
2, Joan Pous
1, Blazej Baginski
1,
Anna Duran-Corbera1, Margherita Scarpa1, Isabelle Brun-Heath
1, Ana Igea1,
Pau Martin-Malpartida
1, ... |
7Z9U | ATAD2 in complex with Acetyl-Lys | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7Z9W | BRD4 in complex with FragLite1 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7Z9Y | BRD4 in complex with FragLite2 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7ZA4 | GSTF sh155 mutant | Citation: Ioannou, E.; Papageorgiou,
A.C.; Labrou, N.E. Directed Evolution
of Phi Class Glutathione Transferases
Involved in Multiple-Herbicide
Resistance of Grass Weeds and Crops.
Int. J. Mol. Sci. 2022, 23, 7469.
https://doi.org/10.3390/
ijms23137469
Academic Editor: Irmgard Tegeder
Received: 1 June 2022
Accepted: 1 ... |
7ZA5 | GSTF sh101 mutant | Citation: Ioannou, E.; Papageorgiou,
A.C.; Labrou, N.E. Directed Evolution
of Phi Class Glutathione Transferases
Involved in Multiple-Herbicide
Resistance of Grass Weeds and Crops.
Int. J. Mol. Sci. 2022, 23, 7469.
https://doi.org/10.3390/
ijms23137469
Academic Editor: Irmgard Tegeder
Received: 1 June 2022
Accepted: 1 ... |
7ZA6 | BRD4 in complex with FragLite4 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7ZA7 | BRD4 in complex with FragLite5 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7ZA8 | BRD4 in complex with FragLite6 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7ZA9 | BRD4 in complex with FragLite7 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7ZAA | BRD4 in complex with FragLite11 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
7ZAB | Sam68 | F U L L - L E N G T H P A P E R
Structure and function analysis of Sam68 and hnRNP A1
synergy in the exclusion of exon 7 from SMN2 transcripts
Marta Nadal1
|
Rosa Anton1
|
Jonatan Dorca-Arévalo1
|
Eva Estébanez-Perpiña2
|
Eduardo F. Tizzano3,4
|
Pablo Fuentes-Prior1
1Molecular Bases of Disease, Biomedical
Research Ins... |
7ZAC | Sam68 | F U L L - L E N G T H P A P E R
Structure and function analysis of Sam68 and hnRNP A1
synergy in the exclusion of exon 7 from SMN2 transcripts
Marta Nadal1
|
Rosa Anton1
|
Jonatan Dorca-Arévalo1
|
Eva Estébanez-Perpiña2
|
Eduardo F. Tizzano3,4
|
Pablo Fuentes-Prior1
1Molecular Bases of Disease, Biomedical
Research Ins... |
7ZAD | BRD4 in complex with FragLite12 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2
with FragLites and PepLitesHalogenated Probes of Druglike and
Peptide-like Molecular Interactions
Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath,
Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand... |
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