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7ZEW
Complex Cyp33-RRM : AAUAAA RNA
C EL L BIOLOGY RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription Markus Blatter1*†, Charlotte Meylan1, Antoine Cléry1, Roberto Giambruno2‡§, Yaroslav Nikolaev1, Michel Heidecker1, Jessica Arvindbhai Solanki3, Manuel O. Diaz3, Davide Gabellini2, Frédéric H.-T. Allain1* Mixed-lineag...
7ZEX
Complex Cyp33-RRMdelta alpha : UAAUGUCG RNA
C EL L BIOLOGY RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription Markus Blatter1*†, Charlotte Meylan1, Antoine Cléry1, Roberto Giambruno2‡§, Yaroslav Nikolaev1, Michel Heidecker1, Jessica Arvindbhai Solanki3, Manuel O. Diaz3, Davide Gabellini2, Frédéric H.-T. Allain1* Mixed-lineag...
7ZEY
Complex Cyp33-RRM : MLL1-PHD3
C EL L BIOLOGY RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription Markus Blatter1*†, Charlotte Meylan1, Antoine Cléry1, Roberto Giambruno2‡§, Yaroslav Nikolaev1, Michel Heidecker1, Jessica Arvindbhai Solanki3, Manuel O. Diaz3, Davide Gabellini2, Frédéric H.-T. Allain1* Mixed-lineag...
7ZEZ
Trimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3
C EL L BIOLOGY RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription Markus Blatter1*†, Charlotte Meylan1, Antoine Cléry1, Roberto Giambruno2‡§, Yaroslav Nikolaev1, Michel Heidecker1, Jessica Arvindbhai Solanki3, Manuel O. Diaz3, Davide Gabellini2, Frédéric H.-T. Allain1* Mixed-lineag...
7ZF0
Crystal structure of UGT85B1 from Sorghum bicolor in complex with UDP and p-hydroxymandelonitrile
Structure-guided engineering of key amino acids in UGT85B1 controlling substrate and stereo-specificity in aromatic cyanogenic glucoside biosynthesis Rita Del Giudice1,† , Natalia Putkaradze2,†, Bruna Marques dos Santos1, Cecilie Cetti Hansen1, Christoph Crocoll3, Mohammed Saddik Motawia1, Folmer Fredslund2, Tomas Laurs...
7ZF1
Structure of ubiquitinated FANCI in complex with FANCD2 and double-stranded DNA
Article Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination Kimon Lemonidis1,* , Martin L Rennie1 , Connor Arkinson1,† , Viduth K Chaugule1 , Mairi Clarke2 , James Streetley2 & Helen Walden1,** Abstract Di-monoubiquitination of the FANCI-FANCD2 (ID2) complex is a central and crucial step for ...
7ZF2
Protomeric substructure from an octameric assembly of M. tuberculosis RNA polymerase in complex with sigma-b initiation factor
Article https://doi.org/10.1038/s41467-023-36113-y Structural basis of the mycobacterial stress- response RNA polymerase auto-inhibition via oligomerization Zakia Morichaud 1, Stefano Trapani 2, Rishi K. Vishwakarma1,4, Laurent Chaloin1, Corinne Lionne 2, Joséphine Lai-Kee-Him2, Patrick Bron 2 & Konstantin Brodolin 1,3...
7ZFN
BRD4 in complex with FragLite24
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZFO
BRD4 in complex with FragLite28
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZFS
BRD4 in complex with FragLite32
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZFT
BRD4 in complex with FragLite33
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZFU
BRD4 in complex with PepLite-Pro
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZFV
BRD4 in complex with PepLite-Ala
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZFW
Structure of human 80S ribosome obtained from ssDNA coated grid
research papers Acta Cryst. (2022). D78, 1337–1346 https://doi.org/10.1107/S2059798322009299 1337 Received 9 June 2022 Accepted 21 September 2022 Edited by B. Kobe, University of Queensland, Australia Keywords: cryo-EM; sample preparation; ssDNA; coating cryo-EM grids; aggregation. EMDB references: hexamerin on ssDNA-c...
7ZFY
BRD4 in complex with PepLite-Gly
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZFZ
BRD4 in complex with PepLite-Val
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZG1
BRD4 in complex with PepLite-Tyr
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZG2
BRD4 in complex with Acetyl-Lys
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions Gemma Davison,§ Mathew P. Martin,§ Shannon Turberville,§ Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sand...
7ZG3
Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH011228
Article https://doi.org/10.1038/s41467-025-56893-9 Virtual fragment screening for DNA repair inhibitors in vast chemical space Andreas Luttens 1,2,3, Duc Duy Vo1, Emma R. Scaletti4, Elisée Wiita5, Ingrid Almlöf5, Olov Wallner5, Jonathan Davies4, Sara Košenina 4, Liuzhen Meng5, Maeve Long5, Oliver Mortusewicz 5, Geoffre...
7ZG4
Crystal structure of YTHDF2 with compound YLI_DF_042
Fragment Ligands of the m6A‑RNA Reader YTHDF2 Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch* Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509 Read Online ACCESS Metrics & More Article Recommendations * sı Supporting Information ABSTRACT: We report 17 small-molecule ...
7ZG5
The crystal structure of Salmonella TacAT3-DNA complex
Molecular Stripping Underpins Derepression of a Toxin-Antitoxin System Grzegorz J. Grabe1,*, Rachel T. Giorgio1, Miłosz Wieczór2, Bridget Gollan1, Molly Sargen1, Modesto Orozco2, Stephen A. Hare3, Sophie Helaine1,* 1Department of Microbiology, Harvard Medical School, Boston, MA, USA 2Institute for Research in Biomedi...
7ZG6
TacA1 antitoxin
Molecular Stripping Underpins Derepression of a Toxin-Antitoxin System Grzegorz J. Grabe1,*, Rachel T. Giorgio1, Miłosz Wieczór2, Bridget Gollan1, Molly Sargen1, Modesto Orozco2, Stephen A. Hare3, Sophie Helaine1,* 1Department of Microbiology, Harvard Medical School, Boston, MA, USA 2Institute for Research in Biomedi...
7ZG7
Structure of human Apoferritin obtained from ssDNA coated grid
research papers Acta Cryst. (2022). D78, 1337–1346 https://doi.org/10.1107/S2059798322009299 1337 Received 9 June 2022 Accepted 21 September 2022 Edited by B. Kobe, University of Queensland, Australia Keywords: cryo-EM; sample preparation; ssDNA; coating cryo-EM grids; aggregation. EMDB references: hexamerin on ssDNA-c...
7ZG8
Crystal structure of A. baumannii penicillin-binding protein 2
PNAS  2023  Vol. 120  No. 8  e2215237120 https://doi.org/10.1073/pnas.2215237120   1 of 10 RESEARCH ARTICLE |  Significance Acinetobacter baumannii is an opportunistic gram-negative bacterial pathogen associated with hospital-acquired infections, and carbapenem-resistant strains present a particularly acute biom...
7ZG9
Structure of yeast Sec14p with himbacine
Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity Received for publication, November 5, 2022, and in revised form, December 27, 2022 Published, Papers in Press, January 2, 2023, https://doi.org/10.1016/j.jbc.2022.102861 Xiao-Ru Chen1 , Lokendra Poudel1, Zebin Hong2, Philipp ...
7ZGA
Structure of yeast Sec14p with ergoline
Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity Received for publication, November 5, 2022, and in revised form, December 27, 2022 Published, Papers in Press, January 2, 2023, https://doi.org/10.1016/j.jbc.2022.102861 Xiao-Ru Chen1 , Lokendra Poudel1, Zebin Hong2, Philipp ...
7ZGB
Structure of yeast Sec14p with NPPM112
Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity Received for publication, November 5, 2022, and in revised form, December 27, 2022 Published, Papers in Press, January 2, 2023, https://doi.org/10.1016/j.jbc.2022.102861 Xiao-Ru Chen1 , Lokendra Poudel1, Zebin Hong2, Philipp ...
7ZGC
Structure of yeast Sec14p with NPPM481
Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity Received for publication, November 5, 2022, and in revised form, December 27, 2022 Published, Papers in Press, January 2, 2023, https://doi.org/10.1016/j.jbc.2022.102861 Xiao-Ru Chen1 , Lokendra Poudel1, Zebin Hong2, Philipp ...
7ZGD
Structure of yeast Sec14p with NPPM244
Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity Received for publication, November 5, 2022, and in revised form, December 27, 2022 Published, Papers in Press, January 2, 2023, https://doi.org/10.1016/j.jbc.2022.102861 Xiao-Ru Chen1 , Lokendra Poudel1, Zebin Hong2, Philipp ...
7ZGI
chloroplast trigger factor (TIG1)
research papers Acta Cryst. (2022). D78, 1259–1272 https://doi.org/10.1107/S2059798322009068 1259 Received 14 April 2022 Accepted 11 September 2022 Edited by K. Djinovic-Carugo, University of Vienna, Austria Keywords: molecular chaperones; chaperone trigger factor; chloroplasts; Chlamydomonas reinhardtii; co-translatio...
7ZGJ
Trypanosoma brucei gambiense ISG65 in complex with human complement component C3
Article https://doi.org/10.1038/s41467-023-37988-7 Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction Hagen Sülzen 1,2, Jakub Began 1,7, Arun Dhillon1, Sami Kereïche1,3, Petr Pompach4, Jitka Votrubova1, Farnaz Zahedifard5, Adriana...
7ZGK
Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b
Article https://doi.org/10.1038/s41467-023-37988-7 Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction Hagen Sülzen 1,2, Jakub Began 1,7, Arun Dhillon1, Sami Kereïche1,3, Petr Pompach4, Jitka Votrubova1, Farnaz Zahedifard5, Adriana...
7ZGL
Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism Madeline E. Kavanagh,* Kirsty J. McLean,* Sophie H. Gilbert, Cecilia N. Amadi, Matthew Snee, Richard B. Tunnicliffe, Kriti Arora, Helena I. M. Boshoff, Alexander Fanourakis, Maria Jose Rebollo-Lopez, Fati...
7ZGM
Plant N-glycan specific alpha-1,3-mannosidase
Plant N-glycan breakdown by human gut Bacteroides Lucy I. Croucha,1 , Paulina A. Urbanowiczb, Arnaud Baslec , Zhi-Peng Caid , Li Liud, Josef Voglmeird, Javier M. Melo Diazb,e, Samuel T. Benedictf, Daniel I. R. Spencerb , and David N. Bolamc,1 Edited by Natalie Ahn, University of Colorado Boulder, Boulder, CO; received...
7ZGN
Plant/insect N-glycan active PNGase
Plant N-glycan breakdown by human gut Bacteroides Lucy I. Croucha,1 , Paulina A. Urbanowiczb, Arnaud Baslec , Zhi-Peng Caid , Li Liud, Josef Voglmeird, Javier M. Melo Diazb,e, Samuel T. Benedictf, Daniel I. R. Spencerb , and David N. Bolamc,1 Edited by Natalie Ahn, University of Colorado Boulder, Boulder, CO; received...
7ZGO
Cryo-EM structure of human NKCC1 (TM domain)
Article Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity Caroline Neumann1,2 , Lena Lindtoft Rosenbæk3 , Rasmus Kock Flygaard1,2 , Michael Habeck1,2 , Jesper Lykkegaard Karlsen2, Yong Wang4,5 , Kresten Lindorff-Larsen4 , Hans Henrik Gad2 , Rune Hartmann2 , Joseph Antho...
7ZGS
Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor 2-phenylethan-1-amine
Discovery of Small-Molecule Allosteric Inhibitors of PfATC as Antimalarials Chao Wang,# Bidong Zhang,# Arne Krüger, Xiaochen Du, Lidia Visser, Alexander S S Dömling, Carsten Wrenger, and Matthew R Groves* Cite This: J. Am. Chem. Soc. 2022, 144, 19070−19077 Read Online ACCESS Metrics & More Article Recommendations * sı...
7ZGX
S-layer Deinoxanthin Binding Complex, C1 symmetry
The cryo-EM structure of the S-layer deinoxanthin-binding complex of Deinococcus radiodurans informs properties of its environmental interactions Received for publication, April 13, 2022, and in revised form, May 10, 2022 Published, Papers in Press, May 13, 2022, https://doi.org/10.1016/j.jbc.2022.102031 Domenica Farci...
7ZGY
S-layer Deinoxanthin Binding Complex, C3 symmetry
The cryo-EM structure of the S-layer deinoxanthin-binding complex of Deinococcus radiodurans informs properties of its environmental interactions Received for publication, April 13, 2022, and in revised form, May 10, 2022 Published, Papers in Press, May 13, 2022, https://doi.org/10.1016/j.jbc.2022.102031 Domenica Farci...
7ZH0
Structure of human OCT3 in lipid nanodisc
Article https://doi.org/10.1038/s41467-022-34284-8 Structural basis of organic cation transporter-3 inhibition Basavraj Khanppnavar1,2,9, Julian Maier 3,9, Freja Herborg 4, Ralph Gradisch 3, Erika Lazzarin3, Dino Luethi 3, Jae-Won Yang 3, Chao Qi 1, Marion Holy3, Kathrin Jäntsch3, Oliver Kudlacek3, Klaus Schicker3, Tho...
7ZH1
SARS CoV Spike protein, Closed C3 conformation
V IRO LOGY The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron Christine Toelzer1,2†, Kapil Gupta1,2,3†, Sathish K. N. Yadav1,2†, Lorna Hodgson1,2†, Maia Kavanagh Williamson4, Dora Buzas1,2,5, Ufuk Borucu1,2, Kyle Powers1,2, Richard Stenne...
7ZH2
SARS CoV Spike protein, Closed C1 conformation
V IRO LOGY The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron Christine Toelzer1,2†, Kapil Gupta1,2,3†, Sathish K. N. Yadav1,2†, Lorna Hodgson1,2†, Maia Kavanagh Williamson4, Dora Buzas1,2,5, Ufuk Borucu1,2, Kyle Powers1,2, Richard Stenne...
7ZH3
USP1 bound to ubiquitin conjugated to FANCD2 (focused refinement)
Rennie et al., Sci. Adv. 8, eabq6353 (2022) 28 September 2022 SCIE N C E A D V A NCES | RESEA R CH A RT ICL E 1 of 8 ST RUCTURAL B IOL OG Y Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site Martin L. Rennie*, Connor Arkinson, Viduth K. Chaugule, Helen Walden* Repair of DNA damage is cr...
7ZH4
USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement)
Rennie et al., Sci. Adv. 8, eabq6353 (2022) 28 September 2022 SCIE N C E A D V A NCES | RESEA R CH A RT ICL E 1 of 8 ST RUCTURAL B IOL OG Y Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site Martin L. Rennie*, Connor Arkinson, Viduth K. Chaugule, Helen Walden* Repair of DNA damage is cr...
7ZH5
SARS CoV Spike protein, Open conformation
V IRO LOGY The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron Christine Toelzer1,2†, Kapil Gupta1,2,3†, Sathish K. N. Yadav1,2†, Lorna Hodgson1,2†, Maia Kavanagh Williamson4, Dora Buzas1,2,5, Ufuk Borucu1,2, Kyle Powers1,2, Richard Stenne...
7ZH6
Structure of human OCT3 in complex with inhibitor Corticosterone
Article https://doi.org/10.1038/s41467-022-34284-8 Structural basis of organic cation transporter-3 inhibition Basavraj Khanppnavar1,2,9, Julian Maier 3,9, Freja Herborg 4, Ralph Gradisch 3, Erika Lazzarin3, Dino Luethi 3, Jae-Won Yang 3, Chao Qi 1, Marion Holy3, Kathrin Jäntsch3, Oliver Kudlacek3, Klaus Schicker3, Tho...
7ZH7
Cryo-EM structure of ex vivo AA amyloid from renal tissue of a short hair cat deceased in a shelter
Article https://doi.org/10.1038/s41467-022-34743-2 Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter Tim Schulte1,13, Antonio Chaves-Sanjuan 2,3,13, Giulia Mazzini 4,5, Valentina Speranzini 2, Francesca Lavatelli 4, Filippo Ferri6, Carlo Palizzotto6, Maria Mazza7, Pa...
7ZH9
Uba1 in complex with ATP
nature communications Article https://doi.org/10.1038/s41467-022-32040-6 Structures of UBA6 explain its dual specificity for ubiquitin and FAT10 Ngoc Truongvan1,2,5, Shurong Li1,5, Mohit Misra1,3,4, Monika Kuhn1 & Hermann Schindelin 1 The covalent modification of target proteins with ubiquitin or ubiquitin-like modifiers ...
7ZHA
Structure of human OCT3 in complex with inhibitor decynium-22
Article https://doi.org/10.1038/s41467-022-34284-8 Structural basis of organic cation transporter-3 inhibition Basavraj Khanppnavar1,2,9, Julian Maier 3,9, Freja Herborg 4, Ralph Gradisch 3, Erika Lazzarin3, Dino Luethi 3, Jae-Won Yang 3, Chao Qi 1, Marion Holy3, Kathrin Jäntsch3, Oliver Kudlacek3, Klaus Schicker3, Tho...
7ZHD
Crystal structure of CtaZ in complex with Closthioamide
Antibiotics A Specialized Polythioamide-Binding Protein Confers Antibiotic Self-Resistance in Anaerobic Bacteria Finn Gude, Evelyn M. Molloy, Therese Horch, Maria Dell, Kyle L. Dunbar, Jana Krabbe, Michael Groll,* and Christian Hertweck* Abstract: Understanding antibiotic resistance mecha- nisms is central to the devel...
7ZHE
Crystal structure of CtaZ from Ruminiclostridium cellulolyticum
Antibiotics A Specialized Polythioamide-Binding Protein Confers Antibiotic Self-Resistance in Anaerobic Bacteria Finn Gude, Evelyn M. Molloy, Therese Horch, Maria Dell, Kyle L. Dunbar, Jana Krabbe, Michael Groll,* and Christian Hertweck* Abstract: Understanding antibiotic resistance mecha- nisms is central to the devel...
7ZHF
GPN-loop GTPase from Sulfolobus acidocaldarius closed state (GppNHp)
| Structural Biology | Research Article Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis Lukas Korf,1 Xing Ye,2 Marian S. Vogt,1 Wieland Steinchen,1,3 Mohamed Watad,1 Chris van der Does,2 Maxime Tourte,2 Shamphavi Sivabalasarma,2,4 Sonja-Verena Albers,2 Lars-Oliver Essen1 AUTHOR AFFI...
7ZHG
High-resolution cryo-EM structure of Pyrococcus abyssi 30S ribosomal subunit bound to mRNA and initiator tRNA anticodon stem-loop
6532–6548 Nucleic Acids Research, 2022, Vol. 50, No. 11 Published online 13 June 2022 https://doi.org/10.1093/nar/gkac490 Role of aIF5B in archaeal translation initiation Ramy Kazan1, Gabrielle Bourgeois1, Christine Lazennec-Schurdevin1, Eric Larquet2, Yves Mechulam1,*, Pierre-Damien Coureux1,* and Emmanuelle Schmitt 1...
7ZHH
Complex structure of drosophila Unr CSD789 and a poly(A) RNA sequence
Published online 23 January 2023 Nucleic Acids Research, 2023, Vol. 51, No. 4 1895–1913 https://doi.org/10.1093/nar/gkac1277 Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein Nele Merret Hollmann1,2, Pravin Kumar Ankush Jagtap 1,3...
7ZHI
Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor indole
Discovery of Small-Molecule Allosteric Inhibitors of PfATC as Antimalarials Chao Wang,# Bidong Zhang,# Arne Krüger, Xiaochen Du, Lidia Visser, Alexander S S Dömling, Carsten Wrenger, and Matthew R Groves* Cite This: J. Am. Chem. Soc. 2022, 144, 19070−19077 Read Online ACCESS Metrics & More Article Recommendations * sı...
7ZHJ
Tail tip of siphophage T5 : tip proteins
ST RUCTURAL BIOLOGY Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation Romain Linares, Charles-Adrien Arnaud, Grégory Effantin, Claudine Darnault, Nathan Hugo Epalle, Elisabetta Boeri Erba, Guy Schoehn, Cécile Breyton* Most bacteriophages present a tail allowing host recognition, c...
7ZHK
GPN-loop GTPase from Sulfolobus acidocaldarius open state (GDP)
| Structural Biology | Research Article Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis Lukas Korf,1 Xing Ye,2 Marian S. Vogt,1 Wieland Steinchen,1,3 Mohamed Watad,1 Chris van der Does,2 Maxime Tourte,2 Shamphavi Sivabalasarma,2,4 Sonja-Verena Albers,2 Lars-Oliver Essen1 AUTHOR AFFI...
7ZHL
Salmonella enterica Rhs1 C-terminal toxin TreTu
13114–13127 Nucleic Acids Research, 2022, Vol. 50, No. 22 Published online 9 December 2022 https://doi.org/10.1093/nar/gkac1162 Salmonella antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of EF-Tu P-loop Dukas Jur˙enas1,*, Martial Rey2, Deborah Byrne3, Julia Chamot-Rooke 2, Laurent Terr...
7ZHM
Salmonella enterica Rhs1 C-terminal toxin TreTu complex with TriTu immunity protein
13114–13127 Nucleic Acids Research, 2022, Vol. 50, No. 22 Published online 9 December 2022 https://doi.org/10.1093/nar/gkac1162 Salmonella antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of EF-Tu P-loop Dukas Jur˙enas1,*, Martial Rey2, Deborah Byrne3, Julia Chamot-Rooke 2, Laurent Terr...
7ZHN
Crystal structure of TTBK1 in complex with AMG28
1 Vol.:(0123456789) Scientific Reports | (2023) 13:6118 | https://doi.org/10.1038/s41598-023-32854-4 www.nature.com/scientificreports Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis Frances M. Bashore  1, Ariana B. Marquez 2, Apirat Chaikuad  3,4, Stefanie Howell  1, Andrea S. Dunn...
7ZHO
Crystal structure of TTBK1 in complex with compound 3 (7-001)
1 Vol.:(0123456789) Scientific Reports | (2023) 13:6118 | https://doi.org/10.1038/s41598-023-32854-4 www.nature.com/scientificreports Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis Frances M. Bashore  1, Ariana B. Marquez 2, Apirat Chaikuad  3,4, Stefanie Howell  1, Andrea S. Dunn...
7ZHP
Crystal structure of TTBK1 in complex with compound 9 (7-005)
1 Vol.:(0123456789) Scientific Reports | (2023) 13:6118 | https://doi.org/10.1038/s41598-023-32854-4 www.nature.com/scientificreports Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis Frances M. Bashore  1, Ariana B. Marquez 2, Apirat Chaikuad  3,4, Stefanie Howell  1, Andrea S. Dunn...
7ZHQ
Crystal structure of TTBK1 in complex with compound 10 (7-009)
1 Vol.:(0123456789) Scientific Reports | (2023) 13:6118 | https://doi.org/10.1038/s41598-023-32854-4 www.nature.com/scientificreports Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis Frances M. Bashore  1, Ariana B. Marquez 2, Apirat Chaikuad  3,4, Stefanie Howell  1, Andrea S. Dunn...
7ZHR
Complex structure of drosophila Unr CSD789 and pAbp RRM3
Published online 23 January 2023 Nucleic Acids Research, 2023, Vol. 51, No. 4 1895–1913 https://doi.org/10.1093/nar/gkac1277 Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein Nele Merret Hollmann1,2, Pravin Kumar Ankush Jagtap 1,3...
7ZHS
3D reconstruction of the cylindrical assembly of DnaJA2 delta G/F by imposing D5 symmetry
Article https://doi.org/10.1038/s41467-023-41150-8 The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70 Lorea Velasco-Carneros 1,2,5, Jorge Cuéllar 3,5, Leire Dublang1,2,5, César Santiago 3, Jean-Didier Maréchal 4, Jaime Martín-Benito 3, Moisés Maestro 3, ...
7ZHT
Leishmania donovani Glucose 6-Phosphate Dehydrogenase apo form
ARTICLE Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain Isabell Berneburg 1, Stefan Rahlfs1, Katja Becker1 & Karin Fritz-Wolf 1,2✉ Since unicellular parasites highly depend on NADPH as a source for reducing equivalents, the pentose phosphate pathway, especia...
7ZHU
Leishmania donovani Glucose 6-Phosphate Dehydrogenase complexed with NADP(H)
ARTICLE Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain Isabell Berneburg 1, Stefan Rahlfs1, Katja Becker1 & Karin Fritz-Wolf 1,2✉ Since unicellular parasites highly depend on NADPH as a source for reducing equivalents, the pentose phosphate pathway, especia...
7ZHV
Leishmania donovani Glucose 6-Phosphate Dehydrogenase complexed with Glucose 6-Phosphate
ARTICLE Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain Isabell Berneburg 1, Stefan Rahlfs1, Katja Becker1 & Karin Fritz-Wolf 1,2✉ Since unicellular parasites highly depend on NADPH as a source for reducing equivalents, the pentose phosphate pathway, especia...
7ZHW
Leishmania donovani Glucose 6-Phosphate Dehydrogenase complexed with NADP(H) and Glucose 6-Phosphate
ARTICLE Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain Isabell Berneburg 1, Stefan Rahlfs1, Katja Becker1 & Karin Fritz-Wolf 1,2✉ Since unicellular parasites highly depend on NADPH as a source for reducing equivalents, the pentose phosphate pathway, especia...
7ZHX
Leishmania donovani Glucose 6-Phosphate Dehydrogenase (N-terminal deletion variant)complexed with NADP(H)
ARTICLE Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain Isabell Berneburg 1, Stefan Rahlfs1, Katja Becker1 & Karin Fritz-Wolf 1,2✉ Since unicellular parasites highly depend on NADPH as a source for reducing equivalents, the pentose phosphate pathway, especia...
7ZHY
Leishmania donovani Glucose 6-Phosphate Dehydrogenase C138S mutant complexed with NADP(H)
ARTICLE Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain Isabell Berneburg 1, Stefan Rahlfs1, Katja Becker1 & Karin Fritz-Wolf 1,2✉ Since unicellular parasites highly depend on NADPH as a source for reducing equivalents, the pentose phosphate pathway, especia...
7ZHZ
Leishmania donovani Glucose 6-Phosphate Dehydrogenase mutant C138S complexed with G6P and NADP(H)
ARTICLE Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain Isabell Berneburg 1, Stefan Rahlfs1, Katja Becker1 & Karin Fritz-Wolf 1,2✉ Since unicellular parasites highly depend on NADPH as a source for reducing equivalents, the pentose phosphate pathway, especia...
7ZI0
Structure of human Smoothened in complex with cholesterol and SAG
Kinnebrew et al., Sci. Adv. 8, eabm5563 (2022) 3 June 2022 SCIE N C E A D V A NCES | RESEA R CH A RT ICL E 1 of 17 BI O CHEM ISTRY Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain Maia Kinnebrew1, Rachel E. Woolley2, T. Bertie Ansell3, Eamon F. X. Byrne2, Sara...
7ZI1
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the dCKi1 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZI2
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the dCKi2 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZI3
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0642 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZI5
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0274 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZI6
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0325 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZI7
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0345 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZI8
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0602 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZI9
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0624 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZIA
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0634 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZIB
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0635 inhibitor
Article https://doi.org/10.1038/s41467-023-38668-2 From a drug repositioning to a structure- based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala 1,6 , Laurent Hoffer 1,4, Sébastien Abel1, Khaoula Ben Yaala1, Benoit Sicard1, Guillaume P. Andrieu 2, Mehdi Latiri2, Emma K. Davison 3,5, Marc...
7ZIC
Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism Madeline E. Kavanagh,* Kirsty J. McLean,* Sophie H. Gilbert, Cecilia N. Amadi, Matthew Snee, Richard B. Tunnicliffe, Kriti Arora, Helena I. M. Boshoff, Alexander Fanourakis, Maria Jose Rebollo-Lopez, Fati...
7ZID
Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with BDA-14
Discovery of Small-Molecule Allosteric Inhibitors of PfATC as Antimalarials Chao Wang,# Bidong Zhang,# Arne Krüger, Xiaochen Du, Lidia Visser, Alexander S S Dömling, Carsten Wrenger, and Matthew R Groves* Cite This: J. Am. Chem. Soc. 2022, 144, 19070−19077 Read Online ACCESS Metrics & More Article Recommendations * sı...
7ZIR
Cryo-EM structure of hnRNPDL amyloid fibrils
Article https://doi.org/10.1038/s41467-023-35854-0 Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb- girdle muscular dystrophy D3 Javier Garcia-Pardo 1, Andrea Bartolomé-Nafría 1, Antonio Chaves-Sanjuan 2,3, Marcos Gil-Garcia 1, Cristina Visentin2,4, Martino Bolognesi 2,3, Stefano Ricagn...
7ZIT
14-3-3 in complex with SARS-COV2 N phospho-peptide
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its C...
7ZIY
X-ray structure of the haloalkane dehalogenase HaloTag7 bound to a pentyltrifluoromethanesulfonamide tetramethylrhodamine ligand (TMR-T5)
Exchangeable HaloTag Ligands for Super-Resolution Fluorescence Microscopy Julian Kompa, Jorick Bruins, Marius Glogger, Jonas Wilhelm, Michelle S. Frei, Miroslaw Tarnawski, Elisa D’Este, Mike Heilemann, Julien Hiblot,* and Kai Johnsson* Cite This: J. Am. Chem. Soc. 2023, 145, 3075−3083 Read Online ACCESS Metrics & More ...
7ZIZ
X-ray structure of the dead variant haloalkane dehalogenase HaloTag7-D106A bound to a pentanol tetramethylrhodamine ligand (TMR-Hy5)
Exchangeable HaloTag Ligands for Super-Resolution Fluorescence Microscopy Julian Kompa, Jorick Bruins, Marius Glogger, Jonas Wilhelm, Michelle S. Frei, Miroslaw Tarnawski, Elisa D’Este, Mike Heilemann, Julien Hiblot,* and Kai Johnsson* Cite This: J. Am. Chem. Soc. 2023, 145, 3075−3083 Read Online ACCESS Metrics & More ...
7ZJ0
X-ray structure of the haloalkane dehalogenase HaloTag7 bound to a pentylmethanesulfonamide tetramethylrhodamine ligand (TMR-S5)
Exchangeable HaloTag Ligands for Super-Resolution Fluorescence Microscopy Julian Kompa, Jorick Bruins, Marius Glogger, Jonas Wilhelm, Michelle S. Frei, Miroslaw Tarnawski, Elisa D’Este, Mike Heilemann, Julien Hiblot,* and Kai Johnsson* Cite This: J. Am. Chem. Soc. 2023, 145, 3075−3083 Read Online ACCESS Metrics & More ...
7ZJ2
Amyloid fibril (in vitro) from full-length hnRNPA1 protein
Cryo-EM structure of the full-length hnRNPA1 amyloid fibril Kartikay Sharma1,*, Sambhasan Banerjee1, Dilan Savran2, Cedric Rajes1, Sebastian Wiese3, Amandeep Girdhar4, Nadine Schwierz5, Christopher Lee4, James Shorter6, Matthias Schmidt1, Lin Guo4,6, Marcus Fändrich1 1Institute of Protein Biochemistry, Ulm University...
7ZJ3
Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate
Article https://doi.org/10.1038/s41467-022-35300-7 Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity Diego Esposito 1, Jane Dudley-Fraser 1, Acely Garza-Garcia 2 & Katrin Rittinger 1 Tripartite motif (TRIM) proteins constitute a large family of RING-type E3 l...
7ZJ6
X-31 Hemagglutinin Precursor HA0 at pH 7.5
Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Eva Garcia-Moroa , Jie Zhangb, Lesley J. Caldera , Nick R. Brownb , Steven J. Gamblinb , John J. Skehelb,1 , and Peter B. Rosenthala,1 Contributed by John J. Skehel; received May 9, 2022; accepted July 1, 2022; reviewed by Steph...
7ZJ7
X-31 Hemagglutinin Precursor HA0 at pH 4.8
Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Eva Garcia-Moroa , Jie Zhangb, Lesley J. Caldera , Nick R. Brownb , Steven J. Gamblinb , John J. Skehelb,1 , and Peter B. Rosenthala,1 Contributed by John J. Skehel; received May 9, 2022; accepted July 1, 2022; reviewed by Steph...
7ZJ8
X-31 Hemagglutinin Precursor HA0 at pH 7.5 after reneutralization
Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Eva Garcia-Moroa , Jie Zhangb, Lesley J. Caldera , Nick R. Brownb , Steven J. Gamblinb , John J. Skehelb,1 , and Peter B. Rosenthala,1 Contributed by John J. Skehel; received May 9, 2022; accepted July 1, 2022; reviewed by Steph...
7ZJB
Structural and functional characterization of the bacterial lytic polysaccharide Monooxygenase ScLPMO10D
1 Vol.:(0123456789) Scientific Reports | (2023) 13:5345 | https://doi.org/10.1038/s41598-023-32263-7 www.nature.com/scientificreports Structural and functional characterization of the catalytic domain of a cell‑wall anchored bacterial lytic polysaccharide monooxygenase from Streptomyces coelicolor Amanda...
7ZJC
Crystal structure (native) of outer surface protein BBA14 (OrfD) from Borrelia burgdorferi
  Citation: Akopjana, I.; Brangulis, K. Structural Analysis of the Outer Membrane Lipoprotein BBA14 (OrfD) and the Corresponding Paralogous Gene Family 143 (PFam143) from Borrelia burgdorferi. Pathogens 2022, 11, 154. https://doi.org/10.3390/ pathogens11020154 Academic Editor: José A. Oteo Received: 11 ...
7ZJD
Transient receptor potential cation channel subfamily V member 2,Enhanced green fluorescent protein
Article https://doi.org/10.1038/s41467-022-35163-y Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function Liying Zhang1,2,3,11, Charlotte Simonsen1,11, Lucie Zimova 4, Kaituo Wang 3, Lavanya Moparthi 5,6, Rachelle Gaudet 7, Maria Ekoff8, Gunnar Nilsson 8, Ute A. Hellmich 9,10, Viktorie Vlachova 4, ...
7ZJE
C16-2
Article https://doi.org/10.1038/s41467-022-35163-y Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function Liying Zhang1,2,3,11, Charlotte Simonsen1,11, Lucie Zimova 4, Kaituo Wang 3, Lavanya Moparthi 5,6, Rachelle Gaudet 7, Maria Ekoff8, Gunnar Nilsson 8, Ute A. Hellmich 9,10, Viktorie Vlachova 4, ...
7ZJG
Probenecid
Article https://doi.org/10.1038/s41467-022-35163-y Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function Liying Zhang1,2,3,11, Charlotte Simonsen1,11, Lucie Zimova 4, Kaituo Wang 3, Lavanya Moparthi 5,6, Rachelle Gaudet 7, Maria Ekoff8, Gunnar Nilsson 8, Ute A. Hellmich 9,10, Viktorie Vlachova 4, ...