protein_name stringlengths 4 4 | structure_title stringlengths 3 322 | main_text stringlengths 0 302k |
|---|---|---|
7YY3 | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 7 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YY4 | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 8 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YY5 | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 9 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YY6 | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 10 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YY7 | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 11 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YY8 | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 12 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YY9 | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 13 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YYA | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 14 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YYB | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 15 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YYC | Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 16 | Structural Characterization of
Mycobacterium abscessus
Phosphopantetheine Adenylyl
Transferase Ligand Interactions:
Implications for Fragment-Based Drug
Design
Sherine E. Thomas 1*†, William J. McCarthy 2†, Jamal El Bakali 2†, Karen P. Brown 3,
So Yeon Kim 1, Michal Blaszczyk 1†, Vítor Mendes 1,3, Chris Abell 2, R. And... |
7YYG | Crystal structure of gatekeeper of type III secretion system in Bordetella BopN | BopN is a Gatekeeper of the Bordetella Type III Secretion System
Kevin Munoz Navarrete,a
Ladislav Bumba,b Tatyana Prudnikova,c Ivana Malcova,a Tania Romero Allsop,a
Peter Sebo,b
Jana Kamanovaa
aLaboratory of Infection Biology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
bLaborator... |
7YYH | Structure of the human CCANdeltaT CENP-A alpha-satellite complex | Structure of the human inner kinetochore bound to a
centromeric CENP-A nucleosome
Stanislau Yatskevich#1, Kyle W. Muir#1, Dom Bellini1, Ziguo Zhang1, Jing Yang1, Thomas
Tischer1, Masa Predin1, Tom Dendooven1, Stephen H. McLaughlin1, David Barford1,*
1MRC Laboratory of Molecular Biology; Francis Crick Avenue, Cambridg... |
7YYI | Solution NMR structure of N-acetylglucosaminyltransferase V (GnTV) TMD | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:20987
| https://doi.org/10.1038/s41598-022-24772-8
www.nature.com/scientificreports
Helical stability of the GnTV
transmembrane domain impacts
on SPPL3 dependent cleavage
Alkmini A. Papadopoulou 1, Walter Stelzer 2, Mara Silber 3,8, Christine Schlosser 1,
C... |
7YYK | Crystal structure of the O-fucosylated form of TSRs1-3 from the human thrombospondin 1 | O-fucosylation stabilizes the TSR3 motif in thrombospondin-1
by interacting with nearby amino acids and protecting a
disulfide bond
Received for publication, April 7, 2022, and in revised form, May 14, 2022 Published, Papers in Press, May 18, 2022,
https://doi.org/10.1016/j.jbc.2022.102047
Steven J. Berardinelli1 , Alex... |
7YYL | nucleotide-free DCCP:DCCP-R complex | Structural basis for coupled ATP-driven electron transfer in the
double-cubane cluster protein
Jae-Hun Jeounga
, Sabine Nicklischa
, and Holger Dobbeka,1
Edited by Douglas Rees, HHMI, California Institute of Technology, Pasadena, CA; received February 28, 2022; accepted June 22, 2022
Electron transfers coupled to the h... |
7YYO | Cryo-EM structure of an a-carboxysome RuBisCO enzyme at 2.9 A resolution | Article
Single-particle cryo-EM analysis of the shell
architecture and internal organization of an intact
a-carboxysome
Graphical abstract
Highlights
d Carboxysomes are prokaryotic microcompartments that
sequester photosynthetic enzymes
d We used single-particle cryo-EM analysis to characterize
intact carboxysome compl... |
7YYP | Structure of aIF5B from Pyrococcus abyssi complexed with GDP | 6532–6548
Nucleic Acids Research, 2022, Vol. 50, No. 11
Published online 13 June 2022
https://doi.org/10.1093/nar/gkac490
Role of aIF5B in archaeal translation initiation
Ramy Kazan1, Gabrielle Bourgeois1, Christine Lazennec-Schurdevin1, Eric Larquet2,
Yves Mechulam1,*, Pierre-Damien Coureux1,* and Emmanuelle Schmitt
1... |
7YYY | Molecular snapshots of drug release from tubulin: 1 microsecond after photoactivation | Article
https://doi.org/10.1038/s41467-023-36481-5
Watching the release of a photo-
pharmacological drug from tubulin
using time-resolved serial crystallography
Maximilian Wranik1, Tobias Weinert
1, Chavdar Slavov
2, Tiziana Masini3,
Antonia Furrer
1, Natacha Gaillard1, Dario Gioia3, Marco Ferrarotti3,
Daniel James1, H... |
7YYZ | Molecular snapshots of drug release from tubulin: 10 microseconds after photoactivation. | Article
https://doi.org/10.1038/s41467-023-36481-5
Watching the release of a photo-
pharmacological drug from tubulin
using time-resolved serial crystallography
Maximilian Wranik1, Tobias Weinert
1, Chavdar Slavov
2, Tiziana Masini3,
Antonia Furrer
1, Natacha Gaillard1, Dario Gioia3, Marco Ferrarotti3,
Daniel James1, H... |
7YZ0 | Molecular snapshots of drug release from tubulin: 100 microseconds after photoactivation. | Article
https://doi.org/10.1038/s41467-023-36481-5
Watching the release of a photo-
pharmacological drug from tubulin
using time-resolved serial crystallography
Maximilian Wranik1, Tobias Weinert
1, Chavdar Slavov
2, Tiziana Masini3,
Antonia Furrer
1, Natacha Gaillard1, Dario Gioia3, Marco Ferrarotti3,
Daniel James1, H... |
7YZ1 | Molecular snapshots of drug release from tubulin: 1 millisecond after photoactivation. | Article
https://doi.org/10.1038/s41467-023-36481-5
Watching the release of a photo-
pharmacological drug from tubulin
using time-resolved serial crystallography
Maximilian Wranik1, Tobias Weinert
1, Chavdar Slavov
2, Tiziana Masini3,
Antonia Furrer
1, Natacha Gaillard1, Dario Gioia3, Marco Ferrarotti3,
Daniel James1, H... |
7YZ2 | Molecular snapshots of drug release from tubulin: 10 milliseconds after photoactivation. | Article
https://doi.org/10.1038/s41467-023-36481-5
Watching the release of a photo-
pharmacological drug from tubulin
using time-resolved serial crystallography
Maximilian Wranik1, Tobias Weinert
1, Chavdar Slavov
2, Tiziana Masini3,
Antonia Furrer
1, Natacha Gaillard1, Dario Gioia3, Marco Ferrarotti3,
Daniel James1, H... |
7YZ3 | Molecular snapshots of drug release from tubulin: Apo state | Article
https://doi.org/10.1038/s41467-023-36481-5
Watching the release of a photo-
pharmacological drug from tubulin
using time-resolved serial crystallography
Maximilian Wranik1, Tobias Weinert
1, Chavdar Slavov
2, Tiziana Masini3,
Antonia Furrer
1, Natacha Gaillard1, Dario Gioia3, Marco Ferrarotti3,
Daniel James1, H... |
7YZ5 | Molecular snapshots of drug release from tubulin: 100 milliseconds (steady state) | Article
https://doi.org/10.1038/s41467-023-36481-5
Watching the release of a photo-
pharmacological drug from tubulin
using time-resolved serial crystallography
Maximilian Wranik1, Tobias Weinert
1, Chavdar Slavov
2, Tiziana Masini3,
Antonia Furrer
1, Natacha Gaillard1, Dario Gioia3, Marco Ferrarotti3,
Daniel James1, H... |
7YZ6 | Molecular snapshots of drug release from tubulin: Dark (steady state) | Article
https://doi.org/10.1038/s41467-023-36481-5
Watching the release of a photo-
pharmacological drug from tubulin
using time-resolved serial crystallography
Maximilian Wranik1, Tobias Weinert
1, Chavdar Slavov
2, Tiziana Masini3,
Antonia Furrer
1, Natacha Gaillard1, Dario Gioia3, Marco Ferrarotti3,
Daniel James1, H... |
7YZ7 | Crystal structure of the zebrafish FoxH1 bound to the TGTGGATT site | Article
https://doi.org/10.1038/s41467-022-34925-y
Molecular basis for DNA recognition by the
maternal pioneer transcription factor FoxH1
Radoslaw Pluta
1,8, Eric Aragón1,8, Nicholas A. Prescott
2,3, Lidia Ruiz1,
Rebeca A. Mees
1, Blazej Baginski
1, Julia R. Flood3, Pau Martin-Malpartida
1,
Joan Massagué
4, Yael David
... |
7YZ9 | Structure of catalytic domain of Rv1625c bound to nanobody NB4 | Mehta, Khanppnavar et al. eLife 2022;11:e77032. DOI: https://doi.org/10.7554/eLife.77032
1 of 21
Structure of Mycobacterium tuberculosis
Cya, an evolutionary ancestor of the
mammalian membrane adenylyl cyclases
Ved Mehta1†, Basavraj Khanppnavar1,2†, Dina Schuster1,2,3, Ilayda Kantarci1,
Irene Vercellino1, Angela K... |
7YZA | Crystal structure of the zebrafish FoxH1 bound to the TGTGTATT site | Article
https://doi.org/10.1038/s41467-022-34925-y
Molecular basis for DNA recognition by the
maternal pioneer transcription factor FoxH1
Radoslaw Pluta
1,8, Eric Aragón1,8, Nicholas A. Prescott
2,3, Lidia Ruiz1,
Rebeca A. Mees
1, Blazej Baginski
1, Julia R. Flood3, Pau Martin-Malpartida
1,
Joan Massagué
4, Yael David
... |
7YZB | Crystal structure of the human FoxH1 bound to the TGTGGATT site | Article
https://doi.org/10.1038/s41467-022-34925-y
Molecular basis for DNA recognition by the
maternal pioneer transcription factor FoxH1
Radoslaw Pluta
1,8, Eric Aragón1,8, Nicholas A. Prescott
2,3, Lidia Ruiz1,
Rebeca A. Mees
1, Blazej Baginski
1, Julia R. Flood3, Pau Martin-Malpartida
1,
Joan Massagué
4, Yael David
... |
7YZC | Crystal structure of the zebrafish FoxH1 bound to the TGTTTATT site | Article
https://doi.org/10.1038/s41467-022-34925-y
Molecular basis for DNA recognition by the
maternal pioneer transcription factor FoxH1
Radoslaw Pluta
1,8, Eric Aragón1,8, Nicholas A. Prescott
2,3, Lidia Ruiz1,
Rebeca A. Mees
1, Blazej Baginski
1, Julia R. Flood3, Pau Martin-Malpartida
1,
Joan Massagué
4, Yael David
... |
7YZD | Crystal structure of the zebrafish FoxH1 bound to the TGTTTACT site (fkh motif GTAAACA) | Article
https://doi.org/10.1038/s41467-022-34925-y
Molecular basis for DNA recognition by the
maternal pioneer transcription factor FoxH1
Radoslaw Pluta
1,8, Eric Aragón1,8, Nicholas A. Prescott
2,3, Lidia Ruiz1,
Rebeca A. Mees
1, Blazej Baginski
1, Julia R. Flood3, Pau Martin-Malpartida
1,
Joan Massagué
4, Yael David
... |
7YZE | Crystal structure of the human FoxA2 bound to the TGTTTACT site (forkhead motif GTAAACA) | Article
https://doi.org/10.1038/s41467-022-34925-y
Molecular basis for DNA recognition by the
maternal pioneer transcription factor FoxH1
Radoslaw Pluta
1,8, Eric Aragón1,8, Nicholas A. Prescott
2,3, Lidia Ruiz1,
Rebeca A. Mees
1, Blazej Baginski
1, Julia R. Flood3, Pau Martin-Malpartida
1,
Joan Massagué
4, Yael David
... |
7YZF | Crystal structure of the human FoxA2 bound to the TGTTTATT site (forkhead motif ATAAACA) | Article
https://doi.org/10.1038/s41467-022-34925-y
Molecular basis for DNA recognition by the
maternal pioneer transcription factor FoxH1
Radoslaw Pluta
1,8, Eric Aragón1,8, Nicholas A. Prescott
2,3, Lidia Ruiz1,
Rebeca A. Mees
1, Blazej Baginski
1, Julia R. Flood3, Pau Martin-Malpartida
1,
Joan Massagué
4, Yael David
... |
7YZG | Crystal structure of the Xenopus FoxH1 bound to the TGTGGATT site | Article
https://doi.org/10.1038/s41467-022-34925-y
Molecular basis for DNA recognition by the
maternal pioneer transcription factor FoxH1
Radoslaw Pluta
1,8, Eric Aragón1,8, Nicholas A. Prescott
2,3, Lidia Ruiz1,
Rebeca A. Mees
1, Blazej Baginski
1, Julia R. Flood3, Pau Martin-Malpartida
1,
Joan Massagué
4, Yael David
... |
7YZH | Schistosoma Mansoni Carbonic Anhydrase in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carbothioamide | RESEARCH PAPER
Development of Praziquantel sulphonamide derivatives as antischistosomal drugs
Andrea Angelia,b
, Marta Ferraronic, Fabrizio Cartaa, Cecile H€aberlid,e
, Jennifer Keiserd,e
, Gabriele
Costantinob and Claudiu T. Supurana
aNEUROFARBA Department, Sezione di Scienze Farmaceutiche, University of Florence, Fl... |
7YZI | Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya | Mehta, Khanppnavar et al. eLife 2022;11:e77032. DOI: https://doi.org/10.7554/eLife.77032
1 of 21
Structure of Mycobacterium tuberculosis
Cya, an evolutionary ancestor of the
mammalian membrane adenylyl cyclases
Ved Mehta1†, Basavraj Khanppnavar1,2†, Dina Schuster1,2,3, Ilayda Kantarci1,
Irene Vercellino1, Angela K... |
7YZK | Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya | Mehta, Khanppnavar et al. eLife 2022;11:e77032. DOI: https://doi.org/10.7554/eLife.77032
1 of 21
Structure of Mycobacterium tuberculosis
Cya, an evolutionary ancestor of the
mammalian membrane adenylyl cyclases
Ved Mehta1†, Basavraj Khanppnavar1,2†, Dina Schuster1,2,3, Ilayda Kantarci1,
Irene Vercellino1, Angela K... |
7YZM | MgADPNP-bound DCCP:DCCP-R complex | Structural basis for coupled ATP-driven electron transfer in the
double-cubane cluster protein
Jae-Hun Jeounga
, Sabine Nicklischa
, and Holger Dobbeka,1
Edited by Douglas Rees, HHMI, California Institute of Technology, Pasadena, CA; received February 28, 2022; accepted June 22, 2022
Electron transfers coupled to the h... |
7YZN | Structure of C-terminally truncated aIF5B from Pyrococcus abyssi complexed with GTP | 6532–6548
Nucleic Acids Research, 2022, Vol. 50, No. 11
Published online 13 June 2022
https://doi.org/10.1093/nar/gkac490
Role of aIF5B in archaeal translation initiation
Ramy Kazan1, Gabrielle Bourgeois1, Christine Lazennec-Schurdevin1, Eric Larquet2,
Yves Mechulam1,*, Pierre-Damien Coureux1,* and Emmanuelle Schmitt
1... |
7YZQ | MgADP-AlF4-bound DCCP:DCCP-R complex | Structural basis for coupled ATP-driven electron transfer in the
double-cubane cluster protein
Jae-Hun Jeounga
, Sabine Nicklischa
, and Holger Dobbeka,1
Edited by Douglas Rees, HHMI, California Institute of Technology, Pasadena, CA; received February 28, 2022; accepted June 22, 2022
Electron transfers coupled to the h... |
7YZR | 50 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model) | The Na+,K+-ATPase in complex with beryllium fluoride mimics
an ATPase phosphorylated state
Received for publication, April 16, 2022, and in revised form, July 23, 2022 Published, Papers in Press, August 2, 2022,
https://doi.org/10.1016/j.jbc.2022.102317
Marlene U. Fruergaard1, Ingrid Dach1, Jacob L. Andersen1,2, Mette O... |
7YZS | Crystal structure of the sulfoquinovosyl binding protein SmoF complexed with sulfoquinovose | The sulfoquinovosyl glycerol binding protein SmoF binds and
accommodates plant sulfolipids
Alexander J.D. Snow a, Mahima Sharma a, James P. Lingford b,c, Yunyang Zhang d,
Janice W.-Y. Mui d, Ruwan Epa d, Ethan D. Goddard-Borger b,c, Spencer J. Williams d, Gideon
J. Davies a,*
a York Structural Biology Laboratory, Depar... |
7YZU | Crystal structure of the sulfoquinovosyl binding protein SmoF complexed with SQMe | The sulfoquinovosyl glycerol binding protein SmoF binds and
accommodates plant sulfolipids
Alexander J.D. Snow a, Mahima Sharma a, James P. Lingford b,c, Yunyang Zhang d,
Janice W.-Y. Mui d, Ruwan Epa d, Ethan D. Goddard-Borger b,c, Spencer J. Williams d, Gideon
J. Davies a,*
a York Structural Biology Laboratory, Depar... |
7YZV | Ryegrass mottle virus serine protease domain S159A mutant | Citation: Kalnins, G.; Ludviga, R.;
Kalnciema, I.; Resevica, G.; Zeltina,
V.; Bogans, J.; Tars, K.; Zeltins, A.;
Balke, I. VPg Impact on Ryegrass
Mottle Virus Serine-like 3C Protease
Proteolysis and Structure. Int. J. Mol.
Sci. 2023, 24, 5347. https://doi.org/
10.3390/ijms24065347
Academic Editor: Irmgard Tegeder
Recei... |
7YZX | ScpA from Streptococcus pyogenes, D783A mutant. | Data in Brief 46 (2023) 108778
Contents lists available at ScienceDirect
Data in Brief
journal homepage: www.elsevier.com/locate/dib
Data Article
X-ray diffraction data for the C5a-peptidase
mutant with modified activity and specificity
Todd F. Kagawa a , c , ∗, Monica Jain a , Jakki C. Cooney a , b , c , ∗
a Depa... |
7YZY | pMMO structure from native membranes by cryoET and STA | nature communications
Article
https://doi.org/10.1038/s41467-022-32752-9
Structure and activity of particulate methane
monooxygenase arrays in methanotrophs
Yanan Zhu
1,8, Christopher W. Koo2,8, C. Keith Cassidy
3, Matthew C. Spink4,
Tao Ni1, Laura C. Zanetti-Domingues
5, Benji Bateman
5,
Marisa L. Martin-Fernandez
5, ... |
7Z01 | Z-SBTubA4 photoswitch bound to tubulin-DARPin D1 complex | In Vivo Photocontrol of Microtubule Dynamics and Integrity,
Migration and Mitosis, by the Potent GFP-Imaging-Compatible
Photoswitchable Reagents SBTubA4P and SBTub2M
Li Gao, Joyce C. M. Meiring, Adam Varady, Iris E. Ruider, Constanze Heise, Maximilian Wranik,
Cecilia D. Velasco, Jennifer A. Taylor, Beatrice Terni, Tobi... |
7Z02 | Z-SBTub2M photoswitch bound to tubulin-DARPin D1 complex | In Vivo Photocontrol of Microtubule Dynamics and Integrity,
Migration and Mitosis, by the Potent GFP-Imaging-Compatible
Photoswitchable Reagents SBTubA4P and SBTub2M
Li Gao, Joyce C. M. Meiring, Adam Varady, Iris E. Ruider, Constanze Heise, Maximilian Wranik,
Cecilia D. Velasco, Jennifer A. Taylor, Beatrice Terni, Tobi... |
7Z04 | 10 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model) | The Na+,K+-ATPase in complex with beryllium fluoride mimics
an ATPase phosphorylated state
Received for publication, April 16, 2022, and in revised form, July 23, 2022 Published, Papers in Press, August 2, 2022,
https://doi.org/10.1016/j.jbc.2022.102317
Marlene U. Fruergaard1, Ingrid Dach1, Jacob L. Andersen1,2, Mette O... |
7Z05 | White Bream virus N7-Methyltransferase | 11186–11198
Nucleic Acids Research, 2022, Vol. 50, No. 19
Published online 21 October 2022
https://doi.org/10.1093/nar/gkac876
A second type of N7-guanine RNA cap
methyltransferase in an unusual locus of a large RNA
virus genome
Ashleigh Shannon
1,†, Bhawna Sama
1,†, Pierre Gauffre
1, Th´eo Guez2,
Franc¸oise Debart
2, ... |
7Z06 | Structure of YwlG (Q2FF14) from Staphylococcus aureus | Bidirectional sequestration between a bacterial hibernation
factor and a glutamate metabolizing protein
David Ranavaa
, Christopher M. Scheidlerb, Martin Pfanzeltc, Michaela Fiedlerc
, Stephan A. Sieberc,1, Sabine Schneiderb,1
, and
Mee-Ngan F. Yapa,1
Edited by Susan Gottesman, NIH, Bethesda, MD; received April 27, 202... |
7Z07 | Solution NMR structure of N-acetylglucosaminyltransferase V (GnTV) G26P mutant TMD | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:20987
| https://doi.org/10.1038/s41598-022-24772-8
www.nature.com/scientificreports
Helical stability of the GnTV
transmembrane domain impacts
on SPPL3 dependent cleavage
Alkmini A. Papadopoulou 1, Walter Stelzer 2, Mara Silber 3,8, Christine Schlosser 1,
C... |
7Z08 | Solution NMR structure of N-acetylglucosaminyltransferase V (GnTV) G22L mutant TMD | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:20987
| https://doi.org/10.1038/s41598-022-24772-8
www.nature.com/scientificreports
Helical stability of the GnTV
transmembrane domain impacts
on SPPL3 dependent cleavage
Alkmini A. Papadopoulou 1, Walter Stelzer 2, Mara Silber 3,8, Christine Schlosser 1,
C... |
7Z0B | Solution NMR structure of N-acetylglucosaminyltransferase V (GnTV) G22L and G26L double mutant TMD | 1
Vol.:(0123456789)
Scientific Reports | (2022) 12:20987
| https://doi.org/10.1038/s41598-022-24772-8
www.nature.com/scientificreports
Helical stability of the GnTV
transmembrane domain impacts
on SPPL3 dependent cleavage
Alkmini A. Papadopoulou 1, Walter Stelzer 2, Mara Silber 3,8, Christine Schlosser 1,
C... |
7Z0F | CPAP:S-TUBULIN:IIH5 ALPHAREP COMPLEX | Structural convergence for tubulin binding of CPAP and vinca
domain microtubule inhibitors
Valerie Campanaccia
, Agathe Urvoasa
, Liza Ammar Khodjaa
, Magali Aumont-Nicaisea
, Magali Noiraya
, Sylvie Lachkarb
, Patrick A. Curmic,
Philippe Minarda, and Benoît Giganta,1
Edited by Eva Nogales, University of California, B... |
7Z0G | CPAP:TUBULIN:IE5 ALPHAREP COMPLEX P1 SPACE GROUP | Structural convergence for tubulin binding of CPAP and vinca
domain microtubule inhibitors
Valerie Campanaccia
, Agathe Urvoasa
, Liza Ammar Khodjaa
, Magali Aumont-Nicaisea
, Magali Noiraya
, Sylvie Lachkarb
, Patrick A. Curmic,
Philippe Minarda, and Benoît Giganta,1
Edited by Eva Nogales, University of California, B... |
7Z0H | Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.6 A (focus subunit AC40). | Article
https://doi.org/10.1038/s41467-023-37109-4
Structural basis of Ty1 integrase tethering
to RNA polymerase III for targeted
retrotransposon integration
Phong Quoc Nguyen
1,2,6, Sonia Huecas1,6, Amna Asif-Laidin
3,6,
Adrián Plaza-Pegueroles
1, Beatrice Capuzzi3, Noé Palmic3, Christine Conesa4,
Joël Acker
4, Juan R... |
7Z0I | human PEX13 SH3 domain | Article
https://doi.org/10.1038/s41467-024-47605-w
Modulation of peroxisomal import by the
PEX13 SH3 domain and a proximal FxxxF
binding motif
Stefan Gaussmann
1,2,5, Rebecca Peschel
3,5, Julia Ott3, Krzysztof M. Zak2,
Judit Sastre4, Florent Delhommel
1,2, Grzegorz M. Popowicz
1,2,
Job Boekhoven
4, Wolfgang Schliebs3, ... |
7Z0J | human PEX13 SH3 domain in complex with internal FxxxF motif | Article
https://doi.org/10.1038/s41467-024-47605-w
Modulation of peroxisomal import by the
PEX13 SH3 domain and a proximal FxxxF
binding motif
Stefan Gaussmann
1,2,5, Rebecca Peschel
3,5, Julia Ott3, Krzysztof M. Zak2,
Judit Sastre4, Florent Delhommel
1,2, Grzegorz M. Popowicz
1,2,
Job Boekhoven
4, Wolfgang Schliebs3, ... |
7Z0K | human PEX13 SH3 in complex with PEX5 W4 (WxxxF/Y) motif | Article
https://doi.org/10.1038/s41467-024-47605-w
Modulation of peroxisomal import by the
PEX13 SH3 domain and a proximal FxxxF
binding motif
Stefan Gaussmann
1,2,5, Rebecca Peschel
3,5, Julia Ott3, Krzysztof M. Zak2,
Judit Sastre4, Florent Delhommel
1,2, Grzegorz M. Popowicz
1,2,
Job Boekhoven
4, Wolfgang Schliebs3, ... |
7Z0L | IL-27 signalling complex | Article
Structural insights into the assembly and activation
of the IL-27 signaling complex
Yibo Jin1,†
, Paul K Fyfe2,†
, Scott Gardner1
, Stephan Wilmes2
, Doryen Bubeck1,*,‡
&
Ignacio Moraga2,**,‡
Abstract
Interleukin 27 (IL-27) is a heterodimeric cytokine that elicits potent
immunosuppressive responses. Comprised o... |
7Z0N | Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators | Structure-Based Design of a Novel Class of Autotaxin Inhibitors
Based on Endogenous Allosteric Modulators
Jennifer M. Clark,∥Fernando Salgado-Polo,∥Simon J. F. Macdonald, Tim N. Barrett,
Anastassis Perrakis,* and Craig Jamieson*
Cite This: J. Med. Chem. 2022, 65, 6338−6351
Read Online
ACCESS
Metrics & More
Article Reco... |
7Z0O | Structure of transcription factor UAF in complex with TBP and 35S rRNA promoter DNA | Baudin et al., Sci. Adv. 8, eabn5725 (2022) 20 April 2022
SCIE N C E A D V A NCES | RESEA R CH A RT ICL E
1 of 9
BI O PH YSICS
Mechanism of RNA polymerase I selection by
transcription factor UAF
Florence Baudin1†, Brice Murciano1†, Herman K. H. Fung1†, Simon A. Fromm1,2†,
Simone Mattei1,2, Julia Mahamid1, Christ... |
7Z0P | SARS-COV2 Main Protease in complex with inhibitor MG-131 | Citation: Göhl, M.; Zhang, L.; El
Kilani, H.; Sun, X.; Zhang, K.;
Brönstrup, M.; Hilgenfeld, R. From
Repurposing to Redesign:
Optimization of Boceprevir to Highly
Potent Inhibitors of the SARS-CoV-2
Main Protease. Molecules 2022, 27,
4292. https://doi.org/10.3390/
molecules27134292
Academic Editor: Joel D. A. Tyndall
R... |
7Z0Q | MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange | Nature Chemical Biology | Volume 19 | October 2023 | 1196–1204
1196
nature chemical biology
Article
https://doi.org/10.1038/s41589-023-01316-3
MHC-II dynamics are maintained in
HLA-DR allotypes to ensure catalyzed
peptide exchange
Esam T. Abualrous
1,2,3,10, Sebastian Stolzenberg2,10, Jana Sticht
1,4,10,
Marek... |
7Z0S | Structure of the Escherichia coli formate hydrogenlyase complex (anaerobic preparation, without formate dehydrogenase H) | nature communications
Article
https://doi.org/10.1038/s41467-022-32831-x
Structure of the membrane-bound formate
hydrogenlyase complex from Escherichia coli
Ralf Steinhilper
1, Gabriele Höff2, Johann Heider2,3 & Bonnie J. Murphy
1
The prototypical hydrogen-producing enzyme, the membrane-bound for-
mate hydrogenlyase (F... |
7Z0T | Structure of the Escherichia coli formate hydrogenlyase complex (aerobic preparation, composite structure) | nature communications
Article
https://doi.org/10.1038/s41467-022-32831-x
Structure of the membrane-bound formate
hydrogenlyase complex from Escherichia coli
Ralf Steinhilper
1, Gabriele Höff2, Johann Heider2,3 & Bonnie J. Murphy
1
The prototypical hydrogen-producing enzyme, the membrane-bound for-
mate hydrogenlyase (F... |
7Z0V | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | Engineering enhanced thermostability into the Geobacillus pallidus
nitrile hydratase
Jennifer C. Van Wyk a,b,e,*, B. Trevor Sewell c,f, Michael J. Danson d, Tsepo L. Tsekoa a,b,g,
Muhammed F. Sayed a,b, Don A. Cowan a,b,h
a Institute for Microbial Biotechnology and Metagenomics, University of the Western Cape, Bellvill... |
7Z0W | E. coli NfsA bound to NADP+ | RESEARCH ARTICLE
The 3D-structure, kinetics and dynamics of the E. coli
nitroreductase NfsA with NADP+ provide glimpses of its
catalytic mechanism
Scott A. White1
, Andrew J. Christofferson2
, Alastair I. Grainger1,*, Martin A. Day1,3,†,
David Jarrom1,‡
, Antonio E. Graziano1,¶, Peter F. Searle3 and Eva I. Hyde1
1 Scho... |
7Z0X | THSC20.HVTR26 Fab bound to SARS-CoV-2 Receptor Binding Domain | RESEARCH ARTICLE
A combination of potently neutralizing
monoclonal antibodies isolated from an
Indian convalescent donor protects against
the SARS-CoV-2 Delta variant
Nitin Hingankar1☯, Suprit Deshpande1☯, Payel Das1, Zaigham Abbas Rizvi2,3,
Constantinos Kurt Wibmer4, Poppy Mashilo4, Mohammed Yousuf Ansari1,
Alison Bur... |
7Z0Y | THSC20.HVTR04 Fab bound to SARS-CoV-2 Receptor Binding Domain | RESEARCH ARTICLE
A combination of potently neutralizing
monoclonal antibodies isolated from an
Indian convalescent donor protects against
the SARS-CoV-2 Delta variant
Nitin Hingankar1☯, Suprit Deshpande1☯, Payel Das1, Zaigham Abbas Rizvi2,3,
Constantinos Kurt Wibmer4, Poppy Mashilo4, Mohammed Yousuf Ansari1,
Alison Bur... |
7Z0Z | Abortive infection DNA polymerase AbiK from Lactococcus lactis, Y44F variant | 10026–10040
Nucleic Acids Research, 2022, Vol. 50, No. 17
Published online 15 September 2022
https://doi.org/10.1093/nar/gkac772
Mechanism of protein-primed template-independent
DNA synthesis by Abi polymerases
Małgorzata Figiel1,*,†, Marta Gapi´nska1,†, Mariusz Czarnocki-Cieciura1, Weronika Zajko1,
Małgorzata Sroka1, ... |
7Z11 | Structure of substrate bound DRG1 (AFG2) | Articles
https://doi.org/10.1038/s41594-022-00832-5
1Institute of Molecular Biosciences, University of Graz, Graz, Austria. 2BioTechMed-Graz, Graz, Austria. 3Research Institute of Molecular Pathology (IMP),
Vienna BioCenter, Vienna, Austria. 4Institute of Science and Technology Austria, Klosterneuburg, Austria. 5Depar... |
7Z12 | VAR2 complex with PAM1.4 | RESEARCH ARTICLE
Cryo-EM reveals the conformational epitope
of human monoclonal antibody PAM1.4
broadly reacting with polymorphic malarial
protein VAR2CSA
Sai Sundar Rajan Raghavan1, Robert Dagil1, Mary Lopez-Perez1, Julian Conrad2, Maria
Rosaria Bassi1, Maria del Pilar Quintana1, Swati Choudhary1, Tobias Gustavsson1,
... |
7Z13 | S. cerevisiae CMGE dimer nucleating origin DNA melting | Nature | Vol 606 | 30 June 2022 | 1007
Article
Mechanism of replication origin melting
nucleated by CMG helicase assembly
Jacob S. Lewis1, Marta H. Gross2,5, Joana Sousa1,4,5, Sarah S. Henrikus1, Julia F. Greiwe1,
Andrea Nans3, John F. X. Diffley2 & Alessandro Costa1 ✉
The activation of eukaryotic origins of re... |
7Z14 | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain neurotoxin. | nature communications
Article
https://doi.org/10.1038/s41467-022-32174-7
The molecular mechanism of snake short-
chain α-neurotoxin binding to muscle-type
nicotinic acetylcholine receptors
Mieke Nys
1,8
, Eleftherios Zarkadas
2,3,8, Marijke Brams
1,
Aujan Mehregan
1, Kumiko Kambara
4, Jeroen Kool
5,
Nicholas R. Casewel... |
7Z15 | E. coli C-P lyase bound to a PhnK/PhnL dual ABC dimer and ADP + Pi | Article
https://doi.org/10.1038/s41467-023-36604-y
Structural remodelling of the
carbon–phosphorus lyase machinery
by a dual ABC ATPase
Søren K. Amstrup1,3, Sui Ching Ong1, Nicholas Sofos1,3, Jesper L. Karlsen1,
Ragnhild B. Skjerning1, Thomas Boesen
2, Jan J. Enghild
1,
Bjarne Hove-Jensen1 & Ditlev E. Brodersen
1
In Es... |
7Z16 | E. coli C-P lyase bound to PhnK/PhnL dual ABC dimer with AMPPNP and PhnK E171Q mutation | Article
https://doi.org/10.1038/s41467-023-36604-y
Structural remodelling of the
carbon–phosphorus lyase machinery
by a dual ABC ATPase
Søren K. Amstrup1,3, Sui Ching Ong1, Nicholas Sofos1,3, Jesper L. Karlsen1,
Ragnhild B. Skjerning1, Thomas Boesen
2, Jan J. Enghild
1,
Bjarne Hove-Jensen1 & Ditlev E. Brodersen
1
In Es... |
7Z17 | E. coli C-P lyase bound to a PhnK ABC dimer in an open conformation | Article
https://doi.org/10.1038/s41467-023-36604-y
Structural remodelling of the
carbon–phosphorus lyase machinery
by a dual ABC ATPase
Søren K. Amstrup1,3, Sui Ching Ong1, Nicholas Sofos1,3, Jesper L. Karlsen1,
Ragnhild B. Skjerning1, Thomas Boesen
2, Jan J. Enghild
1,
Bjarne Hove-Jensen1 & Ditlev E. Brodersen
1
In Es... |
7Z18 | E. coli C-P lyase bound to a PhnK ABC dimer and ATP | Article
https://doi.org/10.1038/s41467-023-36604-y
Structural remodelling of the
carbon–phosphorus lyase machinery
by a dual ABC ATPase
Søren K. Amstrup1,3, Sui Ching Ong1, Nicholas Sofos1,3, Jesper L. Karlsen1,
Ragnhild B. Skjerning1, Thomas Boesen
2, Jan J. Enghild
1,
Bjarne Hove-Jensen1 & Ditlev E. Brodersen
1
In Es... |
7Z19 | E. coli C-P lyase bound to a single PhnK ABC domain | Article
https://doi.org/10.1038/s41467-023-36604-y
Structural remodelling of the
carbon–phosphorus lyase machinery
by a dual ABC ATPase
Søren K. Amstrup1,3, Sui Ching Ong1, Nicholas Sofos1,3, Jesper L. Karlsen1,
Ragnhild B. Skjerning1, Thomas Boesen
2, Jan J. Enghild
1,
Bjarne Hove-Jensen1 & Ditlev E. Brodersen
1
In Es... |
7Z1A | Nanobody H11 and F2 bound to RBD | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z1B | Nanobody H11-A10 and F2 bound to RBD | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z1C | Nanobody H11-B5 and H11-F2 bound to RBD | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z1D | Nanobody H11-H6 bound to RBD | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z1E | Nanobody H11-H4 Q98R H100E bound to RBD | Correlation between the binding affinity and the
conformational entropy of nanobody SARS-CoV-2 spike
protein complexes
Halina Mikolajeka,b,1
, Miriam Weckenerc,1
, Z. Faidon Brotzakisd,1, Jiandong Huob,c,e,1, Evmorfia V. Dalietouc,1, Audrey Le Basb,c,1, Pietro Sormannid
,
Peter J. Harrisona,b, Philip N. Wardb,c
, Steven... |
7Z1H | VAR2CSA APO | RESEARCH ARTICLE
Cryo-EM reveals the conformational epitope
of human monoclonal antibody PAM1.4
broadly reacting with polymorphic malarial
protein VAR2CSA
Sai Sundar Rajan Raghavan1, Robert Dagil1, Mary Lopez-Perez1, Julian Conrad2, Maria
Rosaria Bassi1, Maria del Pilar Quintana1, Swati Choudhary1, Tobias Gustavsson1,
... |
7Z1J | Escherichia coli periplasmic phytase AppA, complex with phosphate | Citation: Acquistapace, I.M.;
Thompson, E.J.; Kühn, I.; Bedford,
M.R.; Brearley, C.A.; Hemmings, A.M.
Insights to the Structural Basis for the
Stereospecificity of the Escherichia coli
Phytase, AppA. Int. J. Mol. Sci. 2022,
23, 6346. https://doi.org/10.3390/
ijms23116346
Academic Editors: Antonio Zuorro,
Yung-Chuan Liu ... |
7Z1K | Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA polymerase II CTD heptapeptide phosphorylated on Ser5 | Article
https://doi.org/10.1038/s41467-023-35853-1
The SPOC domain is a phosphoserine
binding module that bridges transcription
machinery with co- and post-transcriptional
regulators
Lisa-Marie Appel
1,2,3, Vedran Franke
4, Johannes Benedum
1,2,3,5,
Irina Grishkovskaya
6, Xué Strobl3,5, Anton Polyansky
6, Gregor Ammann... |
7Z1P | X-ray crystal structure of SLPYL1-E151D mutant | ORIGINAL RESEARCH
published: 06 June 2022
doi: 10.3389/fpls.2022.884029
Edited by:
Raul Antonio Sperotto,
Universidade do Vale do Taquari -
Univates, Brazil
Reviewed by:
Guangfu Yang,
Central China Normal University,
China
Anil Kumar Singh,
Academy of Scientific and Innovative
Research (AcSIR), India
*Correspondence:
Ar... |
7Z1Q | X-ray crystal structure of SLPYL1-E151D mutant with NIO molecules | ORIGINAL RESEARCH
published: 06 June 2022
doi: 10.3389/fpls.2022.884029
Edited by:
Raul Antonio Sperotto,
Universidade do Vale do Taquari -
Univates, Brazil
Reviewed by:
Guangfu Yang,
Central China Normal University,
China
Anil Kumar Singh,
Academy of Scientific and Innovative
Research (AcSIR), India
*Correspondence:
Ar... |
7Z1R | X-ray crystal structure of SLPYL1-E151D mutant ABA complex | ORIGINAL RESEARCH
published: 06 June 2022
doi: 10.3389/fpls.2022.884029
Edited by:
Raul Antonio Sperotto,
Universidade do Vale do Taquari -
Univates, Brazil
Reviewed by:
Guangfu Yang,
Central China Normal University,
China
Anil Kumar Singh,
Academy of Scientific and Innovative
Research (AcSIR), India
*Correspondence:
Ar... |
7Z1S | X-ray crystal structure of SLPYL1-NIO complex | ORIGINAL RESEARCH
published: 06 June 2022
doi: 10.3389/fpls.2022.884029
Edited by:
Raul Antonio Sperotto,
Universidade do Vale do Taquari -
Univates, Brazil
Reviewed by:
Guangfu Yang,
Central China Normal University,
China
Anil Kumar Singh,
Academy of Scientific and Innovative
Research (AcSIR), India
*Correspondence:
Ar... |
7Z1T | Connexin43 gap junction channel structure in digitonin | Qi, Acosta Gutierrez et al. eLife 2023;12:RP87616. DOI: https://doi.org/10.7554/eLife.87616
1 of 27
Structure of the connexin-43 gap junction
channel in a putative closed state
Chao Qi1,2†, Silvia Acosta Gutierrez3,4†, Pia Lavriha1,2, Alaa Othman5,
Diego Lopez-Pigozzi6,7, Erva Bayraktar7, Dina Schuster1,2,5, Paol... |
7Z1U | Biochemical implications of the substitution of a unique cysteine residue in sugar beet phytoglobin BvPgb 1.2 | Citation: Christensen, S.; Groth, L.;
Leiva-Eriksson, N.; Nyblom, M.;
Bülow, L. Oxidative Implications of
Substituting a Conserved Cysteine
Residue in Sugar Beet Phytoglobin
BvPgb 1.2. Antioxidants 2022, 11, 1615.
https://doi.org/10.3390/
antiox11081615
Academic Editor: Giorgio Ricci
Received: 29 June 2022
Accepted: 17... |
7Z1V | PARP15 catalytic domain in complex with OUL208 | [1,2,4]Triazolo[3,4‑b]benzothiazole Scaffold as Versatile
Nicotinamide Mimic Allowing Nanomolar Inhibition of Different
PARP Enzymes
Sudarshan Murthy,⊥Maria Giulia Nizi,⊥Mirko M. Maksimainen,⊥Serena Massari, Juho Alaviuhkola,
Barbara E. Lippok, Chiara Vagaggini, Sven T. Sowa, Albert Galera-Prat, Yashwanth Ashok,
Harika... |
7Z1W | PARP15 catalytic domain in complex with OUL246 | [1,2,4]Triazolo[3,4‑b]benzothiazole Scaffold as Versatile
Nicotinamide Mimic Allowing Nanomolar Inhibition of Different
PARP Enzymes
Sudarshan Murthy,⊥Maria Giulia Nizi,⊥Mirko M. Maksimainen,⊥Serena Massari, Juho Alaviuhkola,
Barbara E. Lippok, Chiara Vagaggini, Sven T. Sowa, Albert Galera-Prat, Yashwanth Ashok,
Harika... |
7Z1X | Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6 | Article
https://doi.org/10.1038/s41467-023-43707-z
Pyroptosis inhibiting nanobodies block
Gasdermin D pore formation
Anja Kopp
1,2, Gregor Hagelueken
1, Isabell Jamitzky
1, Jonas Moecking
1,
Lisa D. J. Schiffelers
3, Florian I. Schmidt
3 & Matthias Geyer
1
Human Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pr... |
7Z1Y | PARP15 catalytic domain in complex with OUL245 | [1,2,4]Triazolo[3,4‑b]benzothiazole Scaffold as Versatile
Nicotinamide Mimic Allowing Nanomolar Inhibition of Different
PARP Enzymes
Sudarshan Murthy,⊥Maria Giulia Nizi,⊥Mirko M. Maksimainen,⊥Serena Massari, Juho Alaviuhkola,
Barbara E. Lippok, Chiara Vagaggini, Sven T. Sowa, Albert Galera-Prat, Yashwanth Ashok,
Harika... |
7Z20 | 70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia and a stalled filamin domain 5 nascent chain | ARTICLE
Modulating co-translational protein folding by
rational design and ribosome engineering
Minkoo Ahn
1,6, Tomasz Włodarski1,6, Alkistis Mitropoulou1,6, Sammy H. S. Chan
1, Haneesh Sidhu1,
Elena Plessa
1, Thomas A. Becker
2, Nediljko Budisa3,4, Christopher A. Waudby
1, Roland Beckmann
2,
Anaïs M. E. Cassaignau
1, ... |
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