protein_name stringlengths 4 4 | structure_title stringlengths 3 322 | main_text stringlengths 0 302k |
|---|---|---|
7Z21 | BAF A12T bound to the lamin A/C Ig-fold domain | 9260–9278
Nucleic Acids Research, 2022, Vol. 50, No. 16
Published online 30 August 2022
https://doi.org/10.1093/nar/gkac726
The BAF A12T mutation disrupts lamin A/C
interaction, impairing robust repair of nuclear
envelope ruptures in Nestor–Guillermo progeria
syndrome cells
Anne Janssen1, Agathe Marcelot2, Sophia Breus... |
7Z22 | Connexin43 gap junction channel structure in nanodisc | Qi, Acosta Gutierrez et al. eLife 2023;12:RP87616. DOI: https://doi.org/10.7554/eLife.87616
1 of 27
Structure of the connexin-43 gap junction
channel in a putative closed state
Chao Qi1,2†, Silvia Acosta Gutierrez3,4†, Pia Lavriha1,2, Alaa Othman5,
Diego Lopez-Pigozzi6,7, Erva Bayraktar7, Dina Schuster1,2,5, Paol... |
7Z23 | Connexin43 hemi channel in nanodisc | Qi, Acosta Gutierrez et al. eLife 2023;12:RP87616. DOI: https://doi.org/10.7554/eLife.87616
1 of 27
Structure of the connexin-43 gap junction
channel in a putative closed state
Chao Qi1,2†, Silvia Acosta Gutierrez3,4†, Pia Lavriha1,2, Alaa Othman5,
Diego Lopez-Pigozzi6,7, Erva Bayraktar7, Dina Schuster1,2,5, Paol... |
7Z24 | Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with nevirapine | Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1
RT/DNA complexed with inhibitors doravirine and rilpivirine
Abhimanyu K. Singha,b
, Brent De Wijngaerta,b
, Marc Bijnensa,b, Kris Uyttersprota,b, Hoai Nguyenc,d
, Sergio E. Martineza,b, Dominique Scholsa,b,
Piet Herdewijnc,d
, Christophe Pannecouquea,b, Eddy ... |
7Z26 | Crystal structure of YTHDF2 YTH domain in complex with m6A RNA | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
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Supporting Information
ABSTRACT: We report 17 small-molecule ... |
7Z27 | Crystal structure of the SPOC domain of human RBM15 | Article
https://doi.org/10.1038/s41467-023-35853-1
The SPOC domain is a phosphoserine
binding module that bridges transcription
machinery with co- and post-transcriptional
regulators
Lisa-Marie Appel
1,2,3, Vedran Franke
4, Johannes Benedum
1,2,3,5,
Irina Grishkovskaya
6, Xué Strobl3,5, Anton Polyansky
6, Gregor Ammann... |
7Z29 | Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with nevirapine | Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1
RT/DNA complexed with inhibitors doravirine and rilpivirine
Abhimanyu K. Singha,b
, Brent De Wijngaerta,b
, Marc Bijnensa,b, Kris Uyttersprota,b, Hoai Nguyenc,d
, Sergio E. Martineza,b, Dominique Scholsa,b,
Piet Herdewijnc,d
, Christophe Pannecouquea,b, Eddy ... |
7Z2A | P. berghei kinesin-8B motor domain in no nucleotide state bound to tubulin dimer | Article
https://doi.org/10.1038/s41467-022-34710-x
Mechanochemical tuning of a kinesin motor
essential for malaria parasite transmission
Tianyang Liu
1, Fiona Shilliday
1, Alexander D. Cook1,4, Mohammad Zeeshan2,
Declan Brady2, Rita Tewari
2, Colin J. Sutherland
3, Anthony J. Roberts
1 &
Carolyn A. Moores
1
Plasmodium ... |
7Z2B | P. berghei kinesin-8B motor domain in AMPPNP state bound to tubulin dimer | Article
https://doi.org/10.1038/s41467-022-34710-x
Mechanochemical tuning of a kinesin motor
essential for malaria parasite transmission
Tianyang Liu
1, Fiona Shilliday
1, Alexander D. Cook1,4, Mohammad Zeeshan2,
Declan Brady2, Rita Tewari
2, Colin J. Sutherland
3, Anthony J. Roberts
1 &
Carolyn A. Moores
1
Plasmodium ... |
7Z2C | P. falciparum kinesin-8B motor domain in no nucleotide bound to tubulin dimer | Article
https://doi.org/10.1038/s41467-022-34710-x
Mechanochemical tuning of a kinesin motor
essential for malaria parasite transmission
Tianyang Liu
1, Fiona Shilliday
1, Alexander D. Cook1,4, Mohammad Zeeshan2,
Declan Brady2, Rita Tewari
2, Colin J. Sutherland
3, Anthony J. Roberts
1 &
Carolyn A. Moores
1
Plasmodium ... |
7Z2D | Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with rilpivirine | Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1
RT/DNA complexed with inhibitors doravirine and rilpivirine
Abhimanyu K. Singha,b
, Brent De Wijngaerta,b
, Marc Bijnensa,b, Kris Uyttersprota,b, Hoai Nguyenc,d
, Sergio E. Martineza,b, Dominique Scholsa,b,
Piet Herdewijnc,d
, Christophe Pannecouquea,b, Eddy ... |
7Z2E | Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with rilpivirine | Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1
RT/DNA complexed with inhibitors doravirine and rilpivirine
Abhimanyu K. Singha,b
, Brent De Wijngaerta,b
, Marc Bijnensa,b, Kris Uyttersprota,b, Hoai Nguyenc,d
, Sergio E. Martineza,b, Dominique Scholsa,b,
Piet Herdewijnc,d
, Christophe Pannecouquea,b, Eddy ... |
7Z2G | Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine | Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1
RT/DNA complexed with inhibitors doravirine and rilpivirine
Abhimanyu K. Singha,b
, Brent De Wijngaerta,b
, Marc Bijnensa,b, Kris Uyttersprota,b, Hoai Nguyenc,d
, Sergio E. Martineza,b, Dominique Scholsa,b,
Piet Herdewijnc,d
, Christophe Pannecouquea,b, Eddy ... |
7Z2H | Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine | Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1
RT/DNA complexed with inhibitors doravirine and rilpivirine
Abhimanyu K. Singha,b
, Brent De Wijngaerta,b
, Marc Bijnensa,b, Kris Uyttersprota,b, Hoai Nguyenc,d
, Sergio E. Martineza,b, Dominique Scholsa,b,
Piet Herdewijnc,d
, Christophe Pannecouquea,b, Eddy ... |
7Z2J | White Bream virus N7-Methyltransferase | 11186–11198
Nucleic Acids Research, 2022, Vol. 50, No. 19
Published online 21 October 2022
https://doi.org/10.1093/nar/gkac876
A second type of N7-guanine RNA cap
methyltransferase in an unusual locus of a large RNA
virus genome
Ashleigh Shannon
1,†, Bhawna Sama
1,†, Pierre Gauffre
1, Th´eo Guez2,
Franc¸oise Debart
2, ... |
7Z2K | Crystal structure of SARS-CoV-2 Main Protease in orthorhombic space group p212121 | Article
https://doi.org/10.1038/s41467-024-48109-3
SARS-CoV-2 Mpro responds to oxidation by
forming disulfide and NOS/SONOS bonds
A list of authors and their affiliations appears at the end of the paper
The main protease (Mpro) of SARS-CoV-2 is critical for viral function and a key
drug target. Mpro is only active when r... |
7Z2M | Crystal Structure of the 11.003 Fab in complex with human IL-17A | ARTICLE
“Redirecting an anti-IL-1β antibody to bind a new,
unrelated and computationally predicted epitope
on hIL-17A”
Sharon Fischman1,8, Itay Levin1,4,8, Jean-Michel Rondeau
2, Marek Štrajbl
1, Sylvie Lehmann2,
Thomas Huber2,5, Guy Nimrod
1✉, Régis Cebe2, Dotan Omer1,6, Jiri Kovarik2, Shmuel Bernstein1,
Yehezkel Sass... |
7Z2O | PARP15 catalytic domain in complex with OUL215 | [1,2,4]Triazolo[3,4‑b]benzothiazole Scaffold as Versatile
Nicotinamide Mimic Allowing Nanomolar Inhibition of Different
PARP Enzymes
Sudarshan Murthy,⊥Maria Giulia Nizi,⊥Mirko M. Maksimainen,⊥Serena Massari, Juho Alaviuhkola,
Barbara E. Lippok, Chiara Vagaggini, Sven T. Sowa, Albert Galera-Prat, Yashwanth Ashok,
Harika... |
7Z2Q | PARP15 catalytic domain in complex with OUL232 | [1,2,4]Triazolo[3,4‑b]benzothiazole Scaffold as Versatile
Nicotinamide Mimic Allowing Nanomolar Inhibition of Different
PARP Enzymes
Sudarshan Murthy,⊥Maria Giulia Nizi,⊥Mirko M. Maksimainen,⊥Serena Massari, Juho Alaviuhkola,
Barbara E. Lippok, Chiara Vagaggini, Sven T. Sowa, Albert Galera-Prat, Yashwanth Ashok,
Harika... |
7Z2S | Escherichia coli periplasmic phytase AppA, complex with myo-inositol hexakissulfate | Citation: Acquistapace, I.M.;
Thompson, E.J.; Kühn, I.; Bedford,
M.R.; Brearley, C.A.; Hemmings, A.M.
Insights to the Structural Basis for the
Stereospecificity of the Escherichia coli
Phytase, AppA. Int. J. Mol. Sci. 2022,
23, 6346. https://doi.org/10.3390/
ijms23116346
Academic Editors: Antonio Zuorro,
Yung-Chuan Liu ... |
7Z2T | Escherichia coli periplasmic phytase AppA D304A mutant, complex with myo-inositol hexakissulfate | Citation: Acquistapace, I.M.;
Thompson, E.J.; Kühn, I.; Bedford,
M.R.; Brearley, C.A.; Hemmings, A.M.
Insights to the Structural Basis for the
Stereospecificity of the Escherichia coli
Phytase, AppA. Int. J. Mol. Sci. 2022,
23, 6346. https://doi.org/10.3390/
ijms23116346
Academic Editors: Antonio Zuorro,
Yung-Chuan Liu ... |
7Z2U | Wild-type ferulic acid esterase from Lactobacillus buchneri in complex with ferulate | Frontiers in Microbiology
01
frontiersin.org
Crystal structure of the feruloyl
esterase from Lentilactobacillus
buchneri reveals a novel
homodimeric state
Kamyar Mogodiniyai Kasmaei 1,2, Dayanand C. Kalyani 1, Tom
Reichenbach 1, Amparo Jiménez-Quero 3, Francisco Vilaplana 3
and Christina Divne 1*
1 Department of I... |
7Z2V | Ferulic acid esterase variant S114A from Lactobacillus buchneri | Frontiers in Microbiology
01
frontiersin.org
Crystal structure of the feruloyl
esterase from Lentilactobacillus
buchneri reveals a novel
homodimeric state
Kamyar Mogodiniyai Kasmaei 1,2, Dayanand C. Kalyani 1, Tom
Reichenbach 1, Amparo Jiménez-Quero 3, Francisco Vilaplana 3
and Christina Divne 1*
1 Department of I... |
7Z2W | Escherichia coli periplasmic phytase AppA D304A,T305E mutant, complex with myo-inositol hexakissulfate | Citation: Acquistapace, I.M.;
Thompson, E.J.; Kühn, I.; Bedford,
M.R.; Brearley, C.A.; Hemmings, A.M.
Insights to the Structural Basis for the
Stereospecificity of the Escherichia coli
Phytase, AppA. Int. J. Mol. Sci. 2022,
23, 6346. https://doi.org/10.3390/
ijms23116346
Academic Editors: Antonio Zuorro,
Yung-Chuan Liu ... |
7Z2X | Wild-type ferulic acid esterase from Lactobacillus buchneri | Frontiers in Microbiology
01
frontiersin.org
Crystal structure of the feruloyl
esterase from Lentilactobacillus
buchneri reveals a novel
homodimeric state
Kamyar Mogodiniyai Kasmaei 1,2, Dayanand C. Kalyani 1, Tom
Reichenbach 1, Amparo Jiménez-Quero 3, Francisco Vilaplana 3
and Christina Divne 1*
1 Department of I... |
7Z2Y | Escherichia coli periplasmic phytase AppA T305E mutant, complex with myo-inositol hexakissulfate | Citation: Acquistapace, I.M.;
Thompson, E.J.; Kühn, I.; Bedford,
M.R.; Brearley, C.A.; Hemmings, A.M.
Insights to the Structural Basis for the
Stereospecificity of the Escherichia coli
Phytase, AppA. Int. J. Mol. Sci. 2022,
23, 6346. https://doi.org/10.3390/
ijms23116346
Academic Editors: Antonio Zuorro,
Yung-Chuan Liu ... |
7Z2Z | Structure of yeast RNA Polymerase III-DNA-Ty1 integrase complex (Pol III-DNA-IN1) at 3.1 A | Article
https://doi.org/10.1038/s41467-023-37109-4
Structural basis of Ty1 integrase tethering
to RNA polymerase III for targeted
retrotransposon integration
Phong Quoc Nguyen
1,2,6, Sonia Huecas1,6, Amna Asif-Laidin
3,6,
Adrián Plaza-Pegueroles
1, Beatrice Capuzzi3, Noé Palmic3, Christine Conesa4,
Joël Acker
4, Juan R... |
7Z30 | Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.9 A (focus subunit C11 terminal Zn-ribbon in the funnel pore). | Article
https://doi.org/10.1038/s41467-023-37109-4
Structural basis of Ty1 integrase tethering
to RNA polymerase III for targeted
retrotransposon integration
Phong Quoc Nguyen
1,2,6, Sonia Huecas1,6, Amna Asif-Laidin
3,6,
Adrián Plaza-Pegueroles
1, Beatrice Capuzzi3, Noé Palmic3, Christine Conesa4,
Joël Acker
4, Juan R... |
7Z31 | Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.7 A (focus subunit C11, no C11 C-terminal Zn-ribbon in the funnel pore). | Article
https://doi.org/10.1038/s41467-023-37109-4
Structural basis of Ty1 integrase tethering
to RNA polymerase III for targeted
retrotransposon integration
Phong Quoc Nguyen
1,2,6, Sonia Huecas1,6, Amna Asif-Laidin
3,6,
Adrián Plaza-Pegueroles
1, Beatrice Capuzzi3, Noé Palmic3, Christine Conesa4,
Joël Acker
4, Juan R... |
7Z32 | Escherichia coli periplasmic phytase AppA D304A mutant, phosphohistidine intermediate | Citation: Acquistapace, I.M.;
Thompson, E.J.; Kühn, I.; Bedford,
M.R.; Brearley, C.A.; Hemmings, A.M.
Insights to the Structural Basis for the
Stereospecificity of the Escherichia coli
Phytase, AppA. Int. J. Mol. Sci. 2022,
23, 6346. https://doi.org/10.3390/
ijms23116346
Academic Editors: Antonio Zuorro,
Yung-Chuan Liu ... |
7Z34 | Structure of pre-60S particle bound to DRG1(AFG2). | Articles
https://doi.org/10.1038/s41594-022-00832-5
1Institute of Molecular Biosciences, University of Graz, Graz, Austria. 2BioTechMed-Graz, Graz, Austria. 3Research Institute of Molecular Pathology (IMP),
Vienna BioCenter, Vienna, Austria. 4Institute of Science and Technology Austria, Klosterneuburg, Austria. 5Depar... |
7Z36 | Crystal structure of the KAP1 tripartite motif in complex with the ZNF93 KRAB domain | Article
Structure and functional mapping of the
KRAB-KAP1 repressor complex
Guido A Stoll1,2
, Ninoslav Pandiloski3
, Christopher H Douse3
& Yorgo Modis1,2,*
Abstract
Transposable elements are a genetic reservoir from which new
genes and regulatory elements can emerge. However, expression
of transposable elements can b... |
7Z39 | Structure of Belumosudil bound to CK2alpha | research communications
348
https://doi.org/10.1107/S2053230X22008767
Acta Cryst. (2022). F78, 348–353
Received 24 June 2022
Accepted 1 September 2022
Edited by S. Sheriff, Bristol-Myers Squibb, USA
Keywords: belumosudil; CK2 inhibition;
Rho-associated coiled-coil kinase 2; ROCK2
inhibition; kinase inhibitors; selecti... |
7Z3A | AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 | nature communications
Article
https://doi.org/10.1038/s41467-022-32208-0
Identification of IOMA-class neutralizing
antibodies targeting the CD4-binding site on
the HIV-1 envelope glycoprotein
Jelle van Schooten
1, Elinaz Farokhi
2, Anna Schorcht1,
Tom L. G. M. van den Kerkhof1, Hongmei Gao3, Patricia van der Woude1,
Jud... |
7Z3C | Solution structure of GltJ GYF domain from Myxococcus xanthus | Attia et al., Sci. Adv. 10, eadn2789 (2024) 29 May 2024
S c i e n c e A d va n c e s | R e s e a r c h A r t i c l e
1 of 15
M I C R O B I O LO G Y
A molecular switch controls assembly of bacterial
focal adhesions
Bouchra Attia1†, Laetitia My2†, Jean Philippe Castaing2, Céline Dinet2, Hugo Le Guenno3,
Victori... |
7Z3D | XFEL structure of Class Ib ribonucleotide reductase dimanganese(II) NrdF in complex with oxidized NrdI from Bacillus cereus | John et al. eLife 2022;11:e79226. DOI: https://doi.org/10.7554/eLife.79226
1 of 23
Redox-controlled reorganization and
flavin strain within the ribonucleotide
reductase R2b–NrdI complex monitored
by serial femtosecond crystallography
Juliane John1, Oskar Aurelius1,2, Vivek Srinivas1, Patricia Saura1, In-Sik Kim3... |
7Z3E | XFEL structure of Class Ib ribonucleotide reductase dimanganese(II) NrdF in complex with hydroquinone NrdI from Bacillus cereus | John et al. eLife 2022;11:e79226. DOI: https://doi.org/10.7554/eLife.79226
1 of 23
Redox-controlled reorganization and
flavin strain within the ribonucleotide
reductase R2b–NrdI complex monitored
by serial femtosecond crystallography
Juliane John1, Oskar Aurelius1,2, Vivek Srinivas1, Patricia Saura1, In-Sik Kim3... |
7Z3H | Crystal structure of Iba57 from Chaetomium thermophilum | The iron–sulfur cluster assembly (ISC) protein Iba57 executes
a tetrahydrofolate-independent function in mitochondrial
[4Fe–4S] protein maturation
Received for publication, June 3, 2022, and in revised form, August 23, 2022 Published, Papers in Press, September 6, 2022,
https://doi.org/10.1016/j.jbc.2022.102465
Ulrich ... |
7Z3J | Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate | Le Huray et al., Sci. Adv. 8, eabp9688 (2022) 24 June 2022
SCIE N C E A D V A NCES | RESEA R CH A RT ICL E
1 of 15
BI O PH YSICS
Characterization of the membrane interactions
of phospholipase C reveals key features of the
active enzyme
Kyle I. P. Le Huray1,2,3, Tom D. Bunney4*, Nikos Pinotsis5, Antreas C. Kall... |
7Z3N | Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation | Nature Structural & Molecular Biology | Volume 30 | May 2023 | 670–677
670
nature structural & molecular biology
Article
https://doi.org/10.1038/s41594-023-00973-1
Structural inventory of cotranslational
protein folding by the eukaryotic RAC
complex
Miglė Kišonaitė
, Klemens Wild
, Karine Lapouge, Genís Valentí... |
7Z3O | Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation | Nature Structural & Molecular Biology | Volume 30 | May 2023 | 670–677
670
nature structural & molecular biology
Article
https://doi.org/10.1038/s41594-023-00973-1
Structural inventory of cotranslational
protein folding by the eukaryotic RAC
complex
Miglė Kišonaitė
, Klemens Wild
, Karine Lapouge, Genís Valentí... |
7Z3T | Crystal structure of apo human Cathepsin L | ARTICLE
Calpeptin is a potent cathepsin inhibitor and drug
candidate for SARS-CoV-2 infections
Patrick Y. A. Reinke
1,22, Edmarcia Elisa de Souza2,22, Sebastian Günther
1,22, Sven Falke
1, Julia Lieske
1,
Wiebke Ewert
1, Jure Loboda
3,4, Alexander Herrmann
5, Aida Rahmani Mashhour
1,
Katarina Karničar
3,6, Aleksandra U... |
7Z3U | Crystal structure of SARS-CoV-2 Main Protease after incubation with Sulfo-Calpeptin | ARTICLE
Calpeptin is a potent cathepsin inhibitor and drug
candidate for SARS-CoV-2 infections
Patrick Y. A. Reinke
1,22, Edmarcia Elisa de Souza2,22, Sebastian Günther
1,22, Sven Falke
1, Julia Lieske
1,
Wiebke Ewert
1, Jure Loboda
3,4, Alexander Herrmann
5, Aida Rahmani Mashhour
1,
Katarina Karničar
3,6, Aleksandra U... |
7Z3V | Escherichia coli periplasmic phytase AppA D304E mutant, complex with myo-inositol hexakissulfate | Citation: Acquistapace, I.M.;
Thompson, E.J.; Kühn, I.; Bedford,
M.R.; Brearley, C.A.; Hemmings, A.M.
Insights to the Structural Basis for the
Stereospecificity of the Escherichia coli
Phytase, AppA. Int. J. Mol. Sci. 2022,
23, 6346. https://doi.org/10.3390/
ijms23116346
Academic Editors: Antonio Zuorro,
Yung-Chuan Liu ... |
7Z3W | Crystal structure of the AAL160 Fab | ARTICLE
“Redirecting an anti-IL-1β antibody to bind a new,
unrelated and computationally predicted epitope
on hIL-17A”
Sharon Fischman1,8, Itay Levin1,4,8, Jean-Michel Rondeau
2, Marek Štrajbl
1, Sylvie Lehmann2,
Thomas Huber2,5, Guy Nimrod
1✉, Régis Cebe2, Dotan Omer1,6, Jiri Kovarik2, Shmuel Bernstein1,
Yehezkel Sass... |
7Z3Y | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH013545 | Article
https://doi.org/10.1038/s41467-025-56893-9
Virtual fragment screening for DNA repair
inhibitors in vast chemical space
Andreas Luttens
1,2,3, Duc Duy Vo1, Emma R. Scaletti4, Elisée Wiita5,
Ingrid Almlöf5, Olov Wallner5, Jonathan Davies4, Sara Košenina
4,
Liuzhen Meng5, Maeve Long5, Oliver Mortusewicz
5, Geoffre... |
7Z41 | PARP15 catalytic domain in complex with OUL209 | [1,2,4]Triazolo[3,4‑b]benzothiazole Scaffold as Versatile
Nicotinamide Mimic Allowing Nanomolar Inhibition of Different
PARP Enzymes
Sudarshan Murthy,⊥Maria Giulia Nizi,⊥Mirko M. Maksimainen,⊥Serena Massari, Juho Alaviuhkola,
Barbara E. Lippok, Chiara Vagaggini, Sven T. Sowa, Albert Galera-Prat, Yashwanth Ashok,
Harika... |
7Z42 | Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B | RESEARCH ARTICLE
Type B and type A influenza polymerases
have evolved distinct binding interfaces to
recruit the RNA polymerase II CTD
Tim Krischuns1, Catherine Isel1, Petra Drncova2, Maria Lukarska2¤, Alexander Pflug2,
Sylvain Paisant1, Vincent Navratil3, Stephen CusackID2*, Nadia NaffakhID1*
1 Institut Pasteur, Unive... |
7Z43 | Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B | RESEARCH ARTICLE
Type B and type A influenza polymerases
have evolved distinct binding interfaces to
recruit the RNA polymerase II CTD
Tim Krischuns1, Catherine Isel1, Petra Drncova2, Maria Lukarska2¤, Alexander Pflug2,
Sylvain Paisant1, Vincent Navratil3, Stephen CusackID2*, Nadia NaffakhID1*
1 Institut Pasteur, Unive... |
7Z44 | Portal of bacteriophage SU10 | Article
https://doi.org/10.1038/s41467-022-33305-w
Tail proteins of phage SU10 reorganize into
the nozzle for genome delivery
Marta Šiborová
1, Tibor Füzik
1, Michaela Procházková
1, Jiří Nováček1,
Martin Benešík2, Anders S. Nilsson
3 & Pavel Plevka
1
Escherichia coli phage SU10 belongs to the genus Kuravirus from the ... |
7Z45 | Central part (C10) of bacteriophage SU10 capsid | Article
https://doi.org/10.1038/s41467-022-33305-w
Tail proteins of phage SU10 reorganize into
the nozzle for genome delivery
Marta Šiborová
1, Tibor Füzik
1, Michaela Procházková
1, Jiří Nováček1,
Martin Benešík2, Anders S. Nilsson
3 & Pavel Plevka
1
Escherichia coli phage SU10 belongs to the genus Kuravirus from the ... |
7Z46 | Top part (C5) of bacteriophage SU10 capsid | Article
https://doi.org/10.1038/s41467-022-33305-w
Tail proteins of phage SU10 reorganize into
the nozzle for genome delivery
Marta Šiborová
1, Tibor Füzik
1, Michaela Procházková
1, Jiří Nováček1,
Martin Benešík2, Anders S. Nilsson
3 & Pavel Plevka
1
Escherichia coli phage SU10 belongs to the genus Kuravirus from the ... |
7Z47 | Tail of bacteriophage SU10 | Article
https://doi.org/10.1038/s41467-022-33305-w
Tail proteins of phage SU10 reorganize into
the nozzle for genome delivery
Marta Šiborová
1, Tibor Füzik
1, Michaela Procházková
1, Jiří Nováček1,
Martin Benešík2, Anders S. Nilsson
3 & Pavel Plevka
1
Escherichia coli phage SU10 belongs to the genus Kuravirus from the ... |
7Z48 | Bottom part (C5) of bacteriophage SU10 capsid | Article
https://doi.org/10.1038/s41467-022-33305-w
Tail proteins of phage SU10 reorganize into
the nozzle for genome delivery
Marta Šiborová
1, Tibor Füzik
1, Michaela Procházková
1, Jiří Nováček1,
Martin Benešík2, Anders S. Nilsson
3 & Pavel Plevka
1
Escherichia coli phage SU10 belongs to the genus Kuravirus from the ... |
7Z49 | The capsid of bacteriophage SU10. | Article
https://doi.org/10.1038/s41467-022-33305-w
Tail proteins of phage SU10 reorganize into
the nozzle for genome delivery
Marta Šiborová
1, Tibor Füzik
1, Michaela Procházková
1, Jiří Nováček1,
Martin Benešík2, Anders S. Nilsson
3 & Pavel Plevka
1
Escherichia coli phage SU10 belongs to the genus Kuravirus from the ... |
7Z4A | Bacteriophage SU10 tail and bottom part of the capsid (C1) | Article
https://doi.org/10.1038/s41467-022-33305-w
Tail proteins of phage SU10 reorganize into
the nozzle for genome delivery
Marta Šiborová
1, Tibor Füzik
1, Michaela Procházková
1, Jiří Nováček1,
Martin Benešík2, Anders S. Nilsson
3 & Pavel Plevka
1
Escherichia coli phage SU10 belongs to the genus Kuravirus from the ... |
7Z4B | Bacteriophage SU10 virion (C1) | Article
https://doi.org/10.1038/s41467-022-33305-w
Tail proteins of phage SU10 reorganize into
the nozzle for genome delivery
Marta Šiborová
1, Tibor Füzik
1, Michaela Procházková
1, Jiří Nováček1,
Martin Benešík2, Anders S. Nilsson
3 & Pavel Plevka
1
Escherichia coli phage SU10 belongs to the genus Kuravirus from the ... |
7Z4C | SpCas9 bound to 6 nucleotide complementary DNA substrate | Nature | Vol 609 | 1 September 2022 | 191
Article
R-loop formation and conformational
activation mechanisms of Cas9
Martin Pacesa1, Luuk Loeff1,2, Irma Querques1,2, Lena M. Muckenfuss1,2, Marta Sawicka1 &
Martin Jinek1 ✉
Cas9 is a CRISPR-associated endonuclease capable of RNA-guided, site-specific DNA
cleavage... |
7Z4D | Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate | Nature | Vol 609 | 1 September 2022 | 191
Article
R-loop formation and conformational
activation mechanisms of Cas9
Martin Pacesa1, Luuk Loeff1,2, Irma Querques1,2, Lena M. Muckenfuss1,2, Marta Sawicka1 &
Martin Jinek1 ✉
Cas9 is a CRISPR-associated endonuclease capable of RNA-guided, site-specific DNA
cleavage... |
7Z4E | SpCas9 bound to 8-nucleotide complementary DNA substrate | Nature | Vol 609 | 1 September 2022 | 191
Article
R-loop formation and conformational
activation mechanisms of Cas9
Martin Pacesa1, Luuk Loeff1,2, Irma Querques1,2, Lena M. Muckenfuss1,2, Marta Sawicka1 &
Martin Jinek1 ✉
Cas9 is a CRISPR-associated endonuclease capable of RNA-guided, site-specific DNA
cleavage... |
7Z4F | Tail of phage SU10 genome release intermediate | Article
https://doi.org/10.1038/s41467-022-33305-w
Tail proteins of phage SU10 reorganize into
the nozzle for genome delivery
Marta Šiborová
1, Tibor Füzik
1, Michaela Procházková
1, Jiří Nováček1,
Martin Benešík2, Anders S. Nilsson
3 & Pavel Plevka
1
Escherichia coli phage SU10 belongs to the genus Kuravirus from the ... |
7Z4G | SpCas9 bound to 12-nucleotide complementary DNA substrate | Nature | Vol 609 | 1 September 2022 | 191
Article
R-loop formation and conformational
activation mechanisms of Cas9
Martin Pacesa1, Luuk Loeff1,2, Irma Querques1,2, Lena M. Muckenfuss1,2, Marta Sawicka1 &
Martin Jinek1 ✉
Cas9 is a CRISPR-associated endonuclease capable of RNA-guided, site-specific DNA
cleavage... |
7Z4H | SpCas9 bound to 14-nucleotide complementary DNA substrate | Nature | Vol 609 | 1 September 2022 | 191
Article
R-loop formation and conformational
activation mechanisms of Cas9
Martin Pacesa1, Luuk Loeff1,2, Irma Querques1,2, Lena M. Muckenfuss1,2, Marta Sawicka1 &
Martin Jinek1 ✉
Cas9 is a CRISPR-associated endonuclease capable of RNA-guided, site-specific DNA
cleavage... |
7Z4I | SpCas9 bound to 16-nucleotide complementary DNA substrate | Nature | Vol 609 | 1 September 2022 | 191
Article
R-loop formation and conformational
activation mechanisms of Cas9
Martin Pacesa1, Luuk Loeff1,2, Irma Querques1,2, Lena M. Muckenfuss1,2, Marta Sawicka1 &
Martin Jinek1 ✉
Cas9 is a CRISPR-associated endonuclease capable of RNA-guided, site-specific DNA
cleavage... |
7Z4J | SpCas9 bound to 18-nucleotide complementary DNA substrate in the catalytic state | Nature | Vol 609 | 1 September 2022 | 191
Article
R-loop formation and conformational
activation mechanisms of Cas9
Martin Pacesa1, Luuk Loeff1,2, Irma Querques1,2, Lena M. Muckenfuss1,2, Marta Sawicka1 &
Martin Jinek1 ✉
Cas9 is a CRISPR-associated endonuclease capable of RNA-guided, site-specific DNA
cleavage... |
7Z4K | SpCas9 bound to 10-nucleotide complementary DNA substrate | Nature | Vol 609 | 1 September 2022 | 191
Article
R-loop formation and conformational
activation mechanisms of Cas9
Martin Pacesa1, Luuk Loeff1,2, Irma Querques1,2, Lena M. Muckenfuss1,2, Marta Sawicka1 &
Martin Jinek1 ✉
Cas9 is a CRISPR-associated endonuclease capable of RNA-guided, site-specific DNA
cleavage... |
7Z4L | SpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint state | Nature | Vol 609 | 1 September 2022 | 191
Article
R-loop formation and conformational
activation mechanisms of Cas9
Martin Pacesa1, Luuk Loeff1,2, Irma Querques1,2, Lena M. Muckenfuss1,2, Marta Sawicka1 &
Martin Jinek1 ✉
Cas9 is a CRISPR-associated endonuclease capable of RNA-guided, site-specific DNA
cleavage... |
7Z4O | Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A | RESEARCH ARTICLE
Type B and type A influenza polymerases
have evolved distinct binding interfaces to
recruit the RNA polymerase II CTD
Tim Krischuns1, Catherine Isel1, Petra Drncova2, Maria Lukarska2¤, Alexander Pflug2,
Sylvain Paisant1, Vincent Navratil3, Stephen CusackID2*, Nadia NaffakhID1*
1 Institut Pasteur, Unive... |
7Z4S | Crystal structure of SARS-CoV-2 Mpro in complex with cyclic peptide GM4 including unnatural amino acids. | Nature Chemistry | Volume 15 | July 2023 | 998–1005
998
nature chemistry
Article
https://doi.org/10.1038/s41557-023-01205-1
In vitro selection of macrocyclic peptide
inhibitors containing cyclic γ2,4-amino acids
targeting the SARS-CoV-2 main protease
Takashi Miura
1, Tika R. Malla
2, C. David Owen3,4, Anthony T... |
7Z4T | AAL160 FAB IN COMPLEX WITH HUMAN INTERLEUKIN-1 BETA | ARTICLE
“Redirecting an anti-IL-1β antibody to bind a new,
unrelated and computationally predicted epitope
on hIL-17A”
Sharon Fischman1,8, Itay Levin1,4,8, Jean-Michel Rondeau
2, Marek Štrajbl
1, Sylvie Lehmann2,
Thomas Huber2,5, Guy Nimrod
1✉, Régis Cebe2, Dotan Omer1,6, Jiri Kovarik2, Shmuel Bernstein1,
Yehezkel Sass... |
7Z4U | Crystal structure of YTHDF2 with compound YLI_DF_028 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
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ABSTRACT: We report 17 small-molecule ... |
7Z4W | gp6/gp15/gp16 connector complex of bacteriophage SPP1 | Article
https://doi.org/10.1038/s41467-022-34999-8
CryoEM structure and assembly mechanism
of a bacterial virus genome gatekeeper
Igor Orlov1,5,6, Stéphane Roche2,6, Sandrine Brasilès2, Natalya Lukoyanova
3,
Marie-Christine Vaney4, Paulo Tavares
2
& Elena V. Orlova
3
Numerous viruses package their dsDNA genome into pre... |
7Z50 | Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7. | Structural plasticity in I-Ag7 links
autoreactivity to hybrid insulin
peptides in type I diabetes
Elena Erausquin 1,2,3†, Pau Serra 4†, Daniel Parras 4†,
Pere Santamaria 4,5* and Jacinto Lo´ pez-Sagaseta 1,2,3*‡
1Unit of Protein Crystallography and Structural Immunology, Navarrabiomed, Navarra, Spain,
2Public Universit... |
7Z51 | Tick-borne encephalitis virus Kuutsalo-14 |
Citation: Pulkkinen, L.I.A.; Barrass,
S.V.; Domanska, A.; Överby, A.K.;
Anastasina, M.; Butcher, S.J.
Molecular Organisation of Tick-Borne
Encephalitis Virus. Viruses 2022, 14,
792. https://doi.org/10.3390/
v14040792
Academic Editors: David Stuart and
Elizabeth Fry
Received: 25 March 2022
Accepted: 7 ... |
7Z53 | Structure of native leukocyte myeloperoxidase in complex with a truncated version (SPIN truncated) of the Staphyloccal Peroxidase Inhibitor SPIN from Staphylococcus aureus | The staphylococcal inhibitory protein SPIN binds to human
myeloperoxidase with picomolar affinity but only dampens
halide oxidation
Received for publication, July 13, 2022, and in revised form, September 15, 2022 Published, Papers in Press, September 21, 2022,
https://doi.org/10.1016/j.jbc.2022.102514
Urban Leitgeb1, Pa... |
7Z54 | Crystal structure of YTHDF2 with compound YLI_DC1_006 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
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ABSTRACT: We report 17 small-molecule ... |
7Z55 | Crystal Structure of the Ring Nuclease 0455 from Sulfolobus islandicus (Sis0455) in complex with its substrate | Published online 22 October 2022
Nucleic Acids Research, 2022, Vol. 50, No. 19
11199–11213
https://doi.org/10.1093/nar/gkac923
Molecular basis of cyclic tetra-oligoadenylate
processing by small standalone CRISPR-Cas ring
nucleases
Rafael Molina
1,*, Ricardo Garcia-Martin
1, Blanca L´opez-M´endez2,
Anne Louise Grøn Jens... |
7Z56 | Crystal Structure of the Ring Nuclease 0455 from Sulfolobus islandicus (Sis0455) in its apo form | Published online 22 October 2022
Nucleic Acids Research, 2022, Vol. 50, No. 19
11199–11213
https://doi.org/10.1093/nar/gkac923
Molecular basis of cyclic tetra-oligoadenylate
processing by small standalone CRISPR-Cas ring
nucleases
Rafael Molina
1,*, Ricardo Garcia-Martin
1, Blanca L´opez-M´endez2,
Anne Louise Grøn Jens... |
7Z57 | Crystal structure of Human Serum Albumin in complex with surfactant GenX (2,3,3,3-tetrafluoro-2-(heptafluoropropoxy) propanoate) | Investigation of the Interaction between Human Serum Albumin
and Branched Short-Chain Perfluoroalkyl Compounds
Giulia Moro, Stefano Liberi, Filippo Vascon, Sara Linciano, Sofia De Felice, Silvano Fasolato,
Carlo Foresta, Luca De Toni, Andrea Di Nisio, Laura Cendron,* and Alessandro Angelini*
Cite This: Chem. Res. Toxic... |
7Z58 | Crystal structure of human Cathepsin L in complex with covalently bound Calpeptin | ARTICLE
Calpeptin is a potent cathepsin inhibitor and drug
candidate for SARS-CoV-2 infections
Patrick Y. A. Reinke
1,22, Edmarcia Elisa de Souza2,22, Sebastian Günther
1,22, Sven Falke
1, Julia Lieske
1,
Wiebke Ewert
1, Jure Loboda
3,4, Alexander Herrmann
5, Aida Rahmani Mashhour
1,
Katarina Karničar
3,6, Aleksandra U... |
7Z59 | SARS-CoV-2 main protease (Mpro) covalently modified with a penicillin derivative | Penicillin Derivatives Inhibit the SARS-CoV‑2 Main Protease by
Reaction with Its Nucleophilic Cysteine
Tika R. Malla,∥Lennart Brewitz,*,∥Dorian-Gabriel Muntean, Hiba Aslam, C. David Owen,
Eidarus Salah, Anthony Tumber, Petra Lukacik, Claire Strain-Damerell, Halina Mikolajek,
Martin A. Walsh, and Christopher J. Schofield... |
7Z5A | Crystal structure of the trapped complex of mouse Endonuclease VIII-LIKE 3 (mNEIL3) and hairpin DNA with 5'overhang | 10436–10448
Nucleic Acids Research, 2022, Vol. 50, No. 18
Published online 26 September 2022
https://doi.org/10.1093/nar/gkac793
Model of abasic site DNA cross-link repair; from the
architecture of NEIL3 DNA binding domains to the
X-structure model
Andrea Huskova1, Dhurvas Chandrasekaran Dinesh
1, Pavel Srb1, Evzen Bou... |
7Z5B | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH013546 | Article
https://doi.org/10.1038/s41467-025-56893-9
Virtual fragment screening for DNA repair
inhibitors in vast chemical space
Andreas Luttens
1,2,3, Duc Duy Vo1, Emma R. Scaletti4, Elisée Wiita5,
Ingrid Almlöf5, Olov Wallner5, Jonathan Davies4, Sara Košenina
4,
Liuzhen Meng5, Maeve Long5, Oliver Mortusewicz
5, Geoffre... |
7Z5C | Chimera of AP2 with FCHO2 linker domain as a fusion on Cmu2 subunit | Zaccai et al., Sci. Adv. 8, eabn2018 (2022) 29 April 2022
SCIE N C E A D V A NCES | RESEA R CH A RT ICL E
1 of 21
ST RUCTURAL B IOL OG Y
FCHO controls AP2’s initiating role in endocytosis
through a PtdIns(4,5)P2-dependent switch
Nathan R. Zaccai1†, Zuzana Kadlecova1*†, Veronica Kane Dickson1, Kseniya Korobchevska... |
7Z5I | Transcription factor MYF5 bound to symmetrical site | Nature Structural & Molecular Biology | Volume 32 | April 2025 | 650–661
650
nature structural & molecular biology
Article
https://doi.org/10.1038/s41594-024-01449-6
Interfacial water confers transcription
factors with dinucleotide specificity
Ekaterina Morgunova
1, Gabor Nagy
2, Yimeng Yin
3,4, Fangjie Zhu
... |
7Z5K | Transcription factor MYF5 bound to non-symmetrical site | Nature Structural & Molecular Biology | Volume 32 | April 2025 | 650–661
650
nature structural & molecular biology
Article
https://doi.org/10.1038/s41594-024-01449-6
Interfacial water confers transcription
factors with dinucleotide specificity
Ekaterina Morgunova
1, Gabor Nagy
2, Yimeng Yin
3,4, Fangjie Zhu
... |
7Z5M | Crystal structure of YTHDF2 with compound YLI_DC1_008 | Fragment Ligands of the m6A‑RNA Reader YTHDF2
Francesco Nai, Raed Nachawati, František Zálešák, Xiang Wang, Yaozong Li,* and Amedeo Caflisch*
Cite This: ACS Med. Chem. Lett. 2022, 13, 1500−1509
Read Online
ACCESS
Metrics & More
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*
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Supporting Information
ABSTRACT: We report 17 small-molecule ... |
7Z5O | W-formate dehydrogenase from Desulfovibrio vulgaris - Dithionite reduced form | Spectroscopic and Structural Characterization of Reduced
Desulfovibrio vulgaris Hildenborough W‑FdhAB Reveals Stable Metal
Coordination during Catalysis
Ana Rita Oliveira, Cristiano Mota, Kateryna Klymanska, Frédéric Biaso, Maria João Romão,*
Bruno Guigliarelli,* and Inês Cardoso Pereira*
Cite This: ACS Chem. Biol. ... |
7Z5P | Bilirubin oxidase from Bacillus pumilus | Citation: Gihaz, S.; Herzallh, N.S.;
Cohen, Y.; Bachar, O.; Fishman, A.;
Yehezkeli, O. The Structure of
Bilirubin Oxidase from Bacillus
pumilus Reveals a Unique Disulfide
Bond for Site-Specific Direct Electron
Transfer. Biosensors 2022, 12, 258.
https://doi.org/10.3390/
bios12050258
Received: 14 March 2022
Accepted: 15 A... |
7Z5R | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH012035 | Article
https://doi.org/10.1038/s41467-025-56893-9
Virtual fragment screening for DNA repair
inhibitors in vast chemical space
Andreas Luttens
1,2,3, Duc Duy Vo1, Emma R. Scaletti4, Elisée Wiita5,
Ingrid Almlöf5, Olov Wallner5, Jonathan Davies4, Sara Košenina
4,
Liuzhen Meng5, Maeve Long5, Oliver Mortusewicz
5, Geoffre... |
7Z5S | Crystal Structure of botulinum neurotoxin A2 cell binding domain in complex with GD1a | Citation: Gregory, K.S.; Mahadeva,
T.B.; Liu, S.M.; Acharya, K.R.
Structural Features of Clostridium
botulinum Neurotoxin Subtype A2
Cell Binding Domain. Toxins 2022, 14,
356. https://doi.org/10.3390/
toxins14050356
Received: 2 May 2022
Accepted: 18 May 2022
Published: 19 May 2022
Publisher’s Note: MDPI stays neutral
w... |
7Z5T | Crystal Structure of botulinum neurotoxin A2 cell binding domain | Citation: Gregory, K.S.; Mahadeva,
T.B.; Liu, S.M.; Acharya, K.R.
Structural Features of Clostridium
botulinum Neurotoxin Subtype A2
Cell Binding Domain. Toxins 2022, 14,
356. https://doi.org/10.3390/
toxins14050356
Received: 2 May 2022
Accepted: 18 May 2022
Published: 19 May 2022
Publisher’s Note: MDPI stays neutral
w... |
7Z5U | Crystal structure of the peptidase domain of collagenase G from Clostridium histolyticum in complex with a hydroxamate-based inhibitor | Discovery and Characterization of Synthesized and FDA-Approved
Inhibitors of Clostridial and Bacillary Collagenases
Alaa Alhayek,⊥Ahmed S. Abdelsamie,⊥Esther Schönauer, Virgyl Camberlein, Evelyn Hutterer,
Gernot Posselt, Jamil Serwanja, Constantin Blöchl, Christian G. Huber, Jörg Haupenthal,
Hans Brandstetter, Silja We... |
7Z5Y | CRYSTAL STRUCTURE OF WEISSELLA VIRIDESCENS FEMXVV NON-RIBOSOMAL AMINO ACID TRANSFERASE IN COMPLEX WITH A PEPTIDYL-XNA CONJUGATE | Published online 9 November 2022
Nucleic Acids Research, 2022, Vol. 50, No. 20
11415–11425
https://doi.org/10.1093/nar/gkac1023
Amino-acyl tXNA as inhibitors or amino acid donors in
peptide synthesis
Lauriane Rietmeyer
1,†, In`es Li De La Sierra-Gallay
2,†, Guy Schepers3,
Delphine Dorchˆene1, Laura Iannazzo4, Delphine ... |
7Z5Z | CRYSTAL STRUCTURE OF WEISSELLA VIRIDESCENS FEMXVV NON-RIBOSOMAL AMINO ACID TRANSFERASE IN COMPLEX WITH A PEPTIDYL-XNA CONJUGATE | Published online 9 November 2022
Nucleic Acids Research, 2022, Vol. 50, No. 20
11415–11425
https://doi.org/10.1093/nar/gkac1023
Amino-acyl tXNA as inhibitors or amino acid donors in
peptide synthesis
Lauriane Rietmeyer
1,†, In`es Li De La Sierra-Gallay
2,†, Guy Schepers3,
Delphine Dorchˆene1, Laura Iannazzo4, Delphine ... |
7Z61 | Crystal structure of PI3Kgamma with a dihydropurinone inhibitor (compound 18) | Optimization of hERG and Pharmacokinetic Properties for Basic
Dihydro‑8H‑purin-8-one Inhibitors of DNA-PK
Frederick W. Goldberg,* Attilla K. T. Ting, David Beattie, Gillian M. Lamont, Charlene Fallan,
M. Raymond V. Finlay, Beth Williamson, Marianne Schimpl, Alexander R. Harmer,
Oladipupo B. Adeyemi, Pär Nordell, Anna S... |
7Z6A | CRYSTAL STRUCTURE OF WEISSELLA VIRIDESCENS FEMXVV NON-RIBOSOMAL AMINO ACID TRANSFERASE IN COMPLEX WITH A PEPTIDYL-XNA CONJUGATE | Published online 9 November 2022
Nucleic Acids Research, 2022, Vol. 50, No. 20
11415–11425
https://doi.org/10.1093/nar/gkac1023
Amino-acyl tXNA as inhibitors or amino acid donors in
peptide synthesis
Lauriane Rietmeyer
1,†, In`es Li De La Sierra-Gallay
2,†, Guy Schepers3,
Delphine Dorchˆene1, Laura Iannazzo4, Delphine ... |
7Z6B | PET hydrolase PET6 from halophilic organsim Vibrio gazogenes | F U L L - L E N G T H P A P E R
Investigation of the halophilic PET hydrolase PET6 from
Vibrio gazogenes
Sebastian Weigert1
|
Pablo Perez-Garcia2
|
Florian J. Gisdon1
|
Andreas Gagsteiger1
|
Kristine Schweinshaut1
|
G. Matthias Ullmann3
|
Jennifer Chow2
|
Wolfgang R. Streit2
|
Birte Höcker1
1Department of Biochemistry,... |
7Z6C | Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-ispropyl-5-methyl-4-phenoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide. | Targeting Acute Myelogenous Leukemia Using Potent Human
Dihydroorotate Dehydrogenase Inhibitors Based on the
2‑Hydroxypyrazolo[1,5‑a]pyridine Scaffold: SAR of the Aryloxyaryl
Moiety
Stefano Sainas,§§ Marta Giorgis,§§ Paola Circosta, Giulio Poli, Marta Alberti, Alice Passoni,
Valentina Gaidano, Agnese C. Pippione, Nicol... |
7Z6F | Crystal structure of the substrate-binding protein YejA in complex with peptide fragment | PNAS 2025 Vol. 122 No. 1 e2319483121
https://doi.org/10.1073/pnas.2319483121 1 of 10
RESEARCH ARTICLE |
Significance
The need for antibiotics that
target infections from gram-
negative pathogens is a growing
global health concern. Here, we
show that antibiotics with activity
against gram-positive organisms
c... |
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