protein_name stringlengths 4 4 | structure_title stringlengths 3 322 | main_text stringlengths 0 302k |
|---|---|---|
3N4S | Structure of Csm1 C-terminal domain, P21212 form | The monopolin complex cross-links kinetochore components to
regulate chromosome-microtubule attachments
Kevin D. Corbett1, Calvin K. Yip2, Ly-Sha Ee3, Thomas Walz2,4, Angelika Amon3,4, and
Stephen C. Harrison1,4,*
1 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250
Longwood Aven... |
3N4T | apo APH(2")-IVa form I | Crystal structure and kinetic
mechanism of aminoglycoside
phosphotransferase-200-IVa
Marta Toth,1 Hilary Frase,1 Nuno Tiago Antunes,1 Clyde A. Smith,2*
and Sergei B. Vakulenko1*
1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556
2Stanford Synchrotron Radiation Lightsource, St... |
3N4U | app APH(2")-IVa form II | Crystal structure and kinetic
mechanism of aminoglycoside
phosphotransferase-200-IVa
Marta Toth,1 Hilary Frase,1 Nuno Tiago Antunes,1 Clyde A. Smith,2*
and Sergei B. Vakulenko1*
1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556
2Stanford Synchrotron Radiation Lightsource, St... |
3N4V | apo APH(2")-IVa form III | Crystal structure and kinetic
mechanism of aminoglycoside
phosphotransferase-200-IVa
Marta Toth,1 Hilary Frase,1 Nuno Tiago Antunes,1 Clyde A. Smith,2*
and Sergei B. Vakulenko1*
1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556
2Stanford Synchrotron Radiation Lightsource, St... |
3N4X | Structure of Csm1 full-length | The monopolin complex cross-links kinetochore components to
regulate chromosome-microtubule attachments
Kevin D. Corbett1, Calvin K. Yip2, Ly-Sha Ee3, Thomas Walz2,4, Angelika Amon3,4, and
Stephen C. Harrison1,4,*
1 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250
Longwood Aven... |
3N4Y | Crystal structure of wild-type T. celer L30e in low ionic strength condition without precipitant | Electrostatic Contribution of Surface Charge Residues to
the Stability of a Thermophilic Protein: Benchmarking
Experimental and Predicted pKa Values
Chi-Ho Chan1, Cecily C. Wilbanks2, George I. Makhatadze2, Kam-Bo Wong1*
1 Centre for Protein Science and Crystallography, School of Life Science, The Chinese University of... |
3N4Z | Crystal structure of quintuple Arg-to-Lys variant of T. celer L30e | Electrostatic Contribution of Surface Charge Residues to
the Stability of a Thermophilic Protein: Benchmarking
Experimental and Predicted pKa Values
Chi-Ho Chan1, Cecily C. Wilbanks2, George I. Makhatadze2, Kam-Bo Wong1*
1 Centre for Protein Science and Crystallography, School of Life Science, The Chinese University of... |
3N50 | Human Early B-cell factor 3 (EBF3) IPT/TIG and HLHLH domains | Structural Determination of
Functional Domains in Early
B-cell Factor (EBF) Family of
Transcription Factors Reveals
Similarities to Rel DNA-binding
Proteins and a Novel
Dimerization Motif*□
S
Received for publication,June 2, 2010, and in revised form, June 16, 2010
Published, JBC Papers in Press,June 30, 2010, DOI 10.1... |
3N51 | Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor RM-1-95 | Published on Web Date: July 07, 2010
r 2010 American Chemical Society
331
DOI: 10.1021/ml100096t |ACS Med. Chem. Lett. 2010, 1, 331–335
pubs.acs.org/acsmedchemlett
Discovery of Potent and Selective Inhibitors of CDPK1
from C. parvum and T. gondii
Ryan C. Murphy,†,O Kayode K. Ojo,‡,O Eric T. Larson,§,
)
Alejandro Castel... |
3N52 | crystal Structure analysis of MIP2 | A MODEL OF GAG:MIP-2:CXCR2 INTERFACES AND ITS
FUNCTIONAL EFFECTS
Deepa Rajasekaran1, Camille Keeler2, Mansoor A. Syed3, Matthew C. Jones1, Jeffrey K.
Harrison4, Dianqing Wu1, Vineet Bhandari3, Michael E. Hodsdon1,2, and Elias J. Lolis1,5,*
1Department of Pharmacology, Yale University School of Medicine, New Haven, Conn... |
3N54 | Crystal Structure of the GerBC protein | Crystal Structure of the GerBC component of a Bacillus subtilis
Spore Germinant Receptor
Yunfeng Li, Barbara Setlow, Peter Setlow, and Bing Hao*
Department of Molecular, Microbial and Structural Biology, University of Connecticut Health
Center, Farmington, CT 06030-3305, USA
Abstract
The nutrient germinant receptors (n... |
3N55 | SO1698 protein, an aspartic peptidase from Shewanella oneidensis. | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3N5A | Synaptotagmin-7, C2B-domain, calcium bound | Structural and Mutational Analysis of Functional
Differentiation between Synaptotagmins-1 and -7
Mingshan Xue1.¤a, Timothy K. Craig2,3.¤b, Ok-Ho Shin4, Liyi Li1,8, Chad A. Brautigam2, Diana R.
Tomchick2, Thomas C. Su¨ dhof5,6,7, Christian Rosenmund1,8,9,10*, Josep Rizo2,3*
1 Department of Neuroscience, Baylor College o... |
3N5E | Crystal Structure of human thymidylate synthase bound to a peptide inhibitor | Protein–protein interface-binding peptides inhibit the
cancer therapy target human thymidylate synthase
Daniela Cardinalea, Giambattista Guaitolia, Donatella Tondia, Rosaria Luciania, Stefan Henrichb, Outi M. H. Salo-Ahenb,
Stefania Ferraria, Gaetano Marvertic, Davide Guerrieric, Alessio Ligabuec, Chiara Frassinetic, C... |
3N5F | Crystal Structure of L-N-carbamoylase from Geobacillus stearothermophilus CECT43 | Mutational and Structural Analysis of L-N-Carbamoylase Reveals New
Insights into a Peptidase M20/M25/M40 Family Member
Sergio Martínez-Rodríguez,a Abel García-Pino,b Francisco Javier Las Heras-Vázquez,a Josefa María Clemente-Jiménez,a
Felipe Rodríguez-Vico,a Juan M. García-Ruiz,c Remy Loris,b and Jose Antonio Gavirac
D... |
3N5G | Crystal Structure of histidine-tagged human thymidylate synthase | Protein–protein interface-binding peptides inhibit the
cancer therapy target human thymidylate synthase
Daniela Cardinalea, Giambattista Guaitolia, Donatella Tondia, Rosaria Luciania, Stefan Henrichb, Outi M. H. Salo-Ahenb,
Stefania Ferraria, Gaetano Marvertic, Davide Guerrieric, Alessio Ligabuec, Chiara Frassinetic, C... |
3N5K | Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form | Ion Pathways in the
Sarcoplasmic Reticulum
Ca2-ATPase*
Published, JBC Papers in Press, February 11, 2013, DOI 10.1074/jbc.R112.436550
Maike Bublitz‡§1, Maria Musgaard‡¶2, Hanne Poulsen‡§,
Lea Thøgersen‡, Claus Olesen‡**, Birgit Schiøtt¶‡‡§§,
J. Preben Morth‡§3, Jesper Vuust Møller‡**, and Poul Nissen‡§
From the ‡Cent... |
3N5N | Crystal structure analysis of the catalytic domain and interdomain connector of human MutY homologue | A structural hinge in eukaryotic MutY homologues mediates
catalytic activity and Rad9-Rad1-Hus1 checkpoint complex
interactions
Paz J. Luncsford1,†, Dau-Yin Chang1,†, Guoli Shi1,3, Jade Bernstein1, Amrita Madabushi1,
Dimeka N. Patterson1, A-Lien Lu1,2,*, and Eric A. Toth1,2,*
1Department of Biochemistry and Molecular B... |
3N5O | Crystal structure of putative glutathione transferase from Coccidioides immitis bound to glutathione | structural communications
1038
doi:10.1107/S1744309111009493
Acta Cryst. (2011). F67, 1038–1043
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Structures of a putative f-class glutathione
S-transferase from the pathogenic fungus
Coccidioides immitis
Thomas E. Edwar... |
3N5P | Structure of endothelial nitric oxide synthase heme domain complexed with 4-(2-(6-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-2-yl)ethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N5Q | Structure of endothelial nitric oxide synthase heme domain complexed with 6,6'-(2,2'-(5-amino-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N5R | Structure of endothelial nitric oxide synthase heme domain complexed with 4-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N5S | Structure of endothelial nitric oxide synthase heme domain complexed with 4-(2-(5-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)ethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N5T | Structure of endothelial nitric oxide synthase heme domain complexed with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N5U | Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1 | An Overlapping Kinase and Phosphatase Docking Site
Regulates Activity of the Retinoblastoma Protein
Alexander Hirschi1, Matthew Cecchini2, Rachel C. Steinhardt3, Frederick A. Dick2, and Seth
M. Rubin3,*
1)Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz,
CA 95064, USA
2)... |
3N5V | Structure of neuronal nitric oxide synthase heme domain in complex with 4-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N5W | Structure of neuronal nitric oxide synthase heme domain in complex with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N5X | Structure of neuronal nitric oxide synthase heme domain in complex with 4-(2-(5-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)ethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N5Y | Structure of neuronal nitric oxide synthase heme domain in complex with 6,6'-(2,2'-(pyridine-2,6-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N5Z | Structure of neuronal nitric oxide synthase heme domain in complex with 4-(2-(6-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-2-yl)ethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N60 | Structure of neuronal nitric oxide synthase heme domain in complex with 6,6'-(2,2'-(5-amino-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N61 | Structure of neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N62 | Structure of neuronal nitric oxide synthase D597N mutant heme domain in complex with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N63 | Structure of neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with 6,6'-(2,2'-(5-amino-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N64 | Structure of neuronal nitric oxide synthase D597N mutant heme domain in complex with 6,6'-(2,2'-(5-amino-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N65 | Structure of neuronal nitric oxide synthase S602H mutant heme domain in complex with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N66 | Structure of neuronal nitric oxide synthase S602H mutant heme domain in complex with 6,6'-(2,2'-(5-amino-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N67 | Structure of endothelial nitric oxide synthase N368D/V106M double mutant heme domain complexed with 6,6'-(2,2'-(5-amino-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N68 | Structure of endothelial nitric oxide synthase heme domain N368D/V106M double mutant complexed with 4-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N69 | Structure of endothelial nitric oxide synthase N368D/V106M double mutant heme domain complexed with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N6A | Structure of endothelial nitric oxide synthase N368D/V106M double mutant heme domain complexed with 4-(2-(5-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)ethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N6B | Structure of endothelial nitric oxide synthase H373S single mutant heme domain complexed with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N6C | Structure of endothelial nitric oxide synthase H373S single mutant heme domain complexed with 4-(2-(6-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-2-yl)ethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N6D | Structure of endothelial nitric oxide synthase H373S single mutant heme domain complexed with 6,6'-(2,2'-(5-amino-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N6E | Structure of endothelial nitric oxide synthase N368D mutant heme domain complexed with 6,6'-(2,2'-(5-amino-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N6F | Structure of endothelial nitric oxide synthase N368D single mutant heme domain complexed with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine) | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N6G | Structure of endothelial nitric oxide synthase N368D single mutant heme domain complexed with 4-(2-(5-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)ethyl)-6-methylpyridin-2-amine | The Role of Zinc in Isoform Selective Inhibitor Binding to
Neuronal Nitric Oxide Synthase
Silvia L. Delkera, Fengtian Xueb,c, Huiying Lia, Joumana Jamala, Richard B. Silvermanb,*,
and Thomas L. Poulosa,*,†
aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry,
University of Californ... |
3N6L | The crystal structure of RNA-dependent RNA polymerase of EV71 virus | RESEARCH ARTICLE
Structures of EV71 RNA-dependent RNA
polymerase in complex with substrate and
analogue provide a drug target against the
hand-foot-and-mouth disease pandemic in
China
Yang Wu1*, Zhiyong Lou2*, Yi Miao2, Yue Yu2, Hui Dong2, Wei Peng1, Mark Bartlam3, Xuemei Li1,
Zihe Rao1,2,3✉
1 National Laboratory of Ma... |
3N6M | Crystal structure of EV71 RdRp in complex with GTP | RESEARCH ARTICLE
Structures of EV71 RNA-dependent RNA
polymerase in complex with substrate and
analogue provide a drug target against the
hand-foot-and-mouth disease pandemic in
China
Yang Wu1*, Zhiyong Lou2*, Yi Miao2, Yue Yu2, Hui Dong2, Wei Peng1, Mark Bartlam3, Xuemei Li1,
Zihe Rao1,2,3✉
1 National Laboratory of Ma... |
3N6N | crystal structure of EV71 RdRp in complex with Br-UTP | RESEARCH ARTICLE
Structures of EV71 RNA-dependent RNA
polymerase in complex with substrate and
analogue provide a drug target against the
hand-foot-and-mouth disease pandemic in
China
Yang Wu1*, Zhiyong Lou2*, Yi Miao2, Yue Yu2, Hui Dong2, Wei Peng1, Mark Bartlam3, Xuemei Li1,
Zihe Rao1,2,3✉
1 National Laboratory of Ma... |
3N6O | Crystal structure of the GEF and P4M domain of DrrA/SidM from Legionella pneumophila | High-affinity binding of phosphatidylinositol
4-phosphate by Legionella pneumophila DrrA
Stefan Schoebel, Wulf Blankenfeldt, Roger S. Goody+ & Aymelt Itzen++
Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, North Rhine-Westphalia, Germany
The
DrrA
protein
of
Legionella
pneumo... |
3N6Q | Crystal structure of YghZ from E. coli | Macro-to-Micro Structural Proteomics: Native Source
Proteins for High-Throughput Crystallization
Monica Totir1.¤a, Nathaniel Echols1.¤b, Max Nanao2, Christine L. Gee1¤c, Alisa Moskaleva1¤d, Scott
Gradia3, Anthony T. Iavarone3, James M. Berger1, Andrew P. May4, Chloe Zubieta1*¤e, Tom Alber1*
1 Department of Molecular an... |
3N6R | CRYSTAL STRUCTURE OF the holoenzyme of PROPIONYL-COA CARBOXYLASE (PCC) | Crystal structure of the α6β6 holoenzyme of propionyl-coenzyme
A carboxylase
Christine S. Huang1,*, Kianoush Sadre-Bazzaz1,*, Yang Shen1,4, Binbin Deng2, Z. Hong
Zhou2,3, and Liang Tong1
1 Department of Biological Sciences, Columbia University, New York, NY 10027, USA
2 Department of Pathology and Laboratory Medicine... |
3N6V | Structure of the GluA2 NTD-dimer interface mutant, T78A | Subunit-selective N-terminal domain associations
organize the formation of AMPA receptor
heteromers
Maxim Rossmann1,5, Madhav
Sukumaran1,5, Andrew C Penn1,4,5,
Dmitry B Veprintsev2, M Madan Babu3
and Ingo H Greger1,*
1Neurobiology Division, MRC Laboratory of Molecular Biology,
Cambridge, UK, 2MRC Centre for Protein Eng... |
3N71 | Crystal structure of cardiac specific histone methyltransferase SmyD1 | Crystal Structure of Cardiac-specific Histone Methyltransferase
SmyD1 Reveals Unusual Active Site Architecture*
Received for publication,July 24, 2010, and in revised form, September 26, 2010 Published, JBC Papers in Press,October 12, 2010, DOI 10.1074/jbc.M110.168187
Nualpun Sirinupong‡, Joseph Brunzelle§, Jun Ye‡, Al... |
3N75 | X-ray Crystal Structure of the Escherichia coli Inducible Lysine Decarboxylase LdcI | Linkage between the bacterial acid stress and
stringent responses: the structure of the inducible
lysine decarboxylase
Usheer Kanjee1, Irina Gutsche2,
Eftichia Alexopoulos1,3,6, Boyu Zhao1,
Majida El Bakkouri1, Guillaume Thibault1,7,
Kaiyin Liu1, Shaliny Ramachandran1,
Jamie Snider1, Emil F Pai1,3,4,5 and
Walid A Houry... |
3N78 | SgrAI bound to Secondary Site DNA and Mg(II) | research papers
Acta Cryst. (2011). D67, 67–74
doi:10.1107/S0907444910047785
67
Acta Crystallographica Section D
Biological
Crystallography
ISSN 0907-4449
New clues in the allosteric activation of DNA
cleavage by SgrAI: structures of SgrAI bound to
cleaved primary-site DNA and uncleaved
secondary-site DNA
Elizabeth J. ... |
3N79 | PduT C38S Mutant from Salmonella enterica Typhimurium | Structural Insight into the Mechanisms of Transport across
the Salmonella enterica Pdu Microcompartment Shell*□
S
Received for publication,July 1, 2010, and in revised form, September 19, 2010 Published, JBC Papers in Press,September 24, 2010, DOI 10.1074/jbc.M110.160580
Christopher S. Crowley‡, Duilio Cascio¶, Michael... |
3N7B | SgrAI bound to secondary site DNA and Ca(II) | research papers
Acta Cryst. (2011). D67, 67–74
doi:10.1107/S0907444910047785
67
Acta Crystallographica Section D
Biological
Crystallography
ISSN 0907-4449
New clues in the allosteric activation of DNA
cleavage by SgrAI: structures of SgrAI bound to
cleaved primary-site DNA and uncleaved
secondary-site DNA
Elizabeth J. ... |
3N7H | Crystal structure of Odorant Binding Protein 1 from Anopheles gambiae (AgamOBP1) with DEET (N,N-Diethyl-meta-toluamide) and PEG | RESEARCH ARTICLE
Anopheles gambiae odorant binding protein crystal complex
with the synthetic repellent DEET: implications
for structure-based design of novel mosquito repellents
K. E. Tsitsanou • T. Thireou • C. E. Drakou •
K. Koussis • M. V. Keramioti • D. D. Leonidas •
E. Eliopoulos • K. Iatrou • S. E. Zographos
Rec... |
3N7J | Crystal structure of botulinum neurotoxin serotype D binding domain | Identification of a Unique Ganglioside Binding Loop within
Botulinum Neurotoxins C and D-SA
Andrew P-A. KaralewitzA,B, Abby R. KrokenA,B, Zhuji FuC, Michael R. BaldwinD, Jung-Ja P.
KimC,*, and Joseph T. BarbieriA,*
A Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee,
Wisconsin
C... |
3N7K | Crystal structure of botulinum neurotoxin serotype C1 binding domain | Identification of a Unique Ganglioside Binding Loop within
Botulinum Neurotoxins C and D-SA
Andrew P-A. KaralewitzA,B, Abby R. KrokenA,B, Zhuji FuC, Michael R. BaldwinD, Jung-Ja P.
KimC,*, and Joseph T. BarbieriA,*
A Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee,
Wisconsin
C... |
3N7L | Crystal structure of botulinum neurotoxin serotype D/C VPI 5993 binding domain | Identification of a Unique Ganglioside Binding Loop within
Botulinum Neurotoxins C and D-SA
Andrew P-A. KaralewitzA,B, Abby R. KrokenA,B, Zhuji FuC, Michael R. BaldwinD, Jung-Ja P.
KimC,*, and Joseph T. BarbieriA,*
A Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee,
Wisconsin
C... |
3N7M | Crystal structure of W1252A mutant of HCR D/C VPI 5995 | Identification of a Unique Ganglioside Binding Loop within
Botulinum Neurotoxins C and D-SA
Andrew P-A. KaralewitzA,B, Abby R. KrokenA,B, Zhuji FuC, Michael R. BaldwinD, Jung-Ja P.
KimC,*, and Joseph T. BarbieriA,*
A Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee,
Wisconsin
C... |
3N7N | Structure of Csm1/Lrs4 complex | The monopolin complex cross-links kinetochore components to
regulate chromosome-microtubule attachments
Kevin D. Corbett1, Calvin K. Yip2, Ly-Sha Ee3, Thomas Walz2,4, Angelika Amon3,4, and
Stephen C. Harrison1,4,*
1 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250
Longwood Aven... |
3N7X | Crystal structure of Penaeus stylirostris densovirus capsid | JOURNAL OF VIROLOGY, Nov. 2010, p. 11289–11296
Vol. 84, No. 21
0022-538X/10/$12.00
doi:10.1128/JVI.01240-10
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Structure of Penaeus stylirostris Densovirus, a Shrimp Pathogen†
Ba¨rbel Kaufmann,1 Valorie D. Bowman,1 Yi Li,2‡ Jozsef Szelei,2 Peter J.... |
3N7Y | Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV | Published on Web Date: August 17, 2010
r 2010 American Chemical Society
448
DOI: 10.1021/ml100142y |ACS Med. Chem. Lett. 2010, 1, 448–452
pubs.acs.org/acsmedchemlett
Thermodynamic and Structural Effects of Macrocyclic
Constraints in Protein-Ligand Interactions
John E. DeLorbe, John H. Clements, Benjamin B. Whiddon, and... |
3N7Z | Crystal structure of acetyltransferase from Bacillus anthracis | Biochemical and Structural Analysis of an Eis Family
Aminoglycoside Acetyltransferase from Bacillus anthracis
Keith D. Green⊥,◆, Tapan Biswas†,◆, Changsoo Chang∇, Ruiying Wu∇, Wenjing Chen‡,§,
Brian K. Janes∥, Dominika Chalupska○, Piotr Gornicki○, Philip C. Hanna∥, Oleg V.
Tsodikov⊥, Andrzej Joachimiak#,∇, and Sylvi... |
3N84 | Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP | Published on Web Date: August 17, 2010
r 2010 American Chemical Society
448
DOI: 10.1021/ml100142y |ACS Med. Chem. Lett. 2010, 1, 448–452
pubs.acs.org/acsmedchemlett
Thermodynamic and Structural Effects of Macrocyclic
Constraints in Protein-Ligand Interactions
John E. DeLorbe, John H. Clements, Benjamin B. Whiddon, and... |
3N89 | KH domains | REPORT
Four KH domains of the C. elegans Bicaudal-C ortholog
GLD-3 form a globular structural platform
KATHARINA NAKEL,1 SOPHIA A. HARTUNG,2 FABIEN BONNEAU,1 CHRISTIAN R. ECKMANN,3
and ELENA CONTI1
1Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, D-82152 Martinsried, Germany
2Lawrence Berke... |
3N8B | Crystal Structure of Borrelia burgdorferi Pur-alpha | Of Bits and Bugs — On the Use of Bioinformatics and a
Bacterial Crystal Structure to Solve a Eukaryotic Repeat-
Protein Structure
Almut Graebsch1,2, Ste´phane Roche1,2, Dirk Kostrewa2, Johannes So¨ ding2, Dierk Niessing1,2*
1 Institute of Structural Biology, Helmholtz Zentrum Mu¨nchen, Munich, Germany, 2 Department of ... |
3N8D | Crystal structure of Staphylococcus aureus VRSA-9 D-Ala:D-Ala ligase | JOURNAL OF BACTERIOLOGY, Oct. 2010, p. 5465–5471
Vol. 192, No. 20
0021-9193/10/$12.00
doi:10.1128/JB.00613-10
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Molecular Basis of Vancomycin Dependence in
VanA-Type Staphylococcus aureus VRSA-9
Djalal Meziane-Cherif,1 Frederick A. Saul,2 Carole M... |
3N8G | Structure of the (SR)Ca2+-ATPase Ca2-E1-CaAMPPCP form | Ion Pathways in the
Sarcoplasmic Reticulum
Ca2-ATPase*
Published, JBC Papers in Press, February 11, 2013, DOI 10.1074/jbc.R112.436550
Maike Bublitz‡§1, Maria Musgaard‡¶2, Hanne Poulsen‡§,
Lea Thøgersen‡, Claus Olesen‡**, Birgit Schiøtt¶‡‡§§,
J. Preben Morth‡§3, Jesper Vuust Møller‡**, and Poul Nissen‡§
From the ‡Cent... |
3N8M | Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP | Published on Web Date: August 17, 2010
r 2010 American Chemical Society
448
DOI: 10.1021/ml100142y |ACS Med. Chem. Lett. 2010, 1, 448–452
pubs.acs.org/acsmedchemlett
Thermodynamic and Structural Effects of Macrocyclic
Constraints in Protein-Ligand Interactions
John E. DeLorbe, John H. Clements, Benjamin B. Whiddon, and... |
3N8S | Crystal Structure of BlaC-E166A covalently bound with Cefamandole | Structures of the Michaelis-Complex (1.2 Å) and the Covalent
Acyl-Intermediate (2.0 Å) of Cefamandole Bound in the Active
Sites of the Mycobacterium tuberculosis β-Lactamase K73A and
E166A Mutants
Lee W. Tremblay, Hua Xu, and John S. Blanchard*
Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morri... |
3N8U | Crystal structure of an imelysin peptidase (BACOVA_03801) from Bacteroides ovatus at 1.44 A resolution | Structural and Sequence Analysis of Imelysin-Like
Proteins Implicated in Bacterial Iron Uptake
Qingping Xu1,2, Neil D. Rawlings3, Carol L. Farr1,4, Hsiu-Ju Chiu1,2, Joanna C. Grant1,5, Lukasz
Jaroszewski1,6,7, Heath E. Klock1,5, Mark W. Knuth1,5, Mitchell D. Miller1,2, Dana Weekes1,7, Marc-Andre´
Elsliger1,4, Ashley M.... |
3N8V | Crystal Structure of Unoccupied Cyclooxygenase-1 | Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk
Between Monomers Comprising Cyclooxygenase-1 Homodimers
Ranjinder S. Sidhu, Jullia Y. Lee, Chong Yuan, and William L. Smith*
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 USA
Abstract
Prostaglandin endoperoxide H synthases (... |
3N8W | Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with Flurbiprofen | Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk
Between Monomers Comprising Cyclooxygenase-1 Homodimers
Ranjinder S. Sidhu, Jullia Y. Lee, Chong Yuan, and William L. Smith*
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 USA
Abstract
Prostaglandin endoperoxide H synthases (... |
3N8X | Crystal Structure of Cyclooxygenase-1 in Complex with Nimesulide | Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk
Between Monomers Comprising Cyclooxygenase-1 Homodimers
Ranjinder S. Sidhu, Jullia Y. Lee, Chong Yuan, and William L. Smith*
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 USA
Abstract
Prostaglandin endoperoxide H synthases (... |
3N8Y | Structure of Aspirin Acetylated Cyclooxygenase-1 in Complex with Diclofenac | Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk
Between Monomers Comprising Cyclooxygenase-1 Homodimers
Ranjinder S. Sidhu, Jullia Y. Lee, Chong Yuan, and William L. Smith*
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 USA
Abstract
Prostaglandin endoperoxide H synthases (... |
3N8Z | Crystal Structure of Cyclooxygenase-1 in Complex with Flurbiprofen | Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk
Between Monomers Comprising Cyclooxygenase-1 Homodimers
Ranjinder S. Sidhu, Jullia Y. Lee, Chong Yuan, and William L. Smith*
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 USA
Abstract
Prostaglandin endoperoxide H synthases (... |
3N94 | Crystal structure of human pituitary adenylate cyclase 1 Receptor-short N-terminal extracellular domain | Crystal Structure of the PAC1R Extracellular Domain
Unifies a Consensus Fold for Hormone Recognition by
Class B G-Protein Coupled Receptors
Shiva Kumar1,2, Augen Pioszak1¤, Chenghai Zhang1, Kunchithapadam Swaminathan2*, H. Eric Xu1*
1 Laboratory of Structural Sciences, Van Andel Research Institute, Grand Rapids, Michig... |
3N97 | RNA polymerase alpha C-terminal domain (E. coli) and sigma region 4 (T. aq. mutant) bound to (UP,-35 element) DNA | RNA polymerase alpha subunit recognizes the DNA shape of the
Upstream Promoter element
Samuel Lara-Gonzalez1,§, Ana Carolina Dantas Machado2,§, Satyanarayan Rao2,§, Andrew
A. Napoli1, Jens Birktoft1, Rosa Di Felice2,3,4, Remo Rohs2,3,5,6,*, Catherine L. Lawson1,7,*
1Department of Chemistry and Chemical Biology, Rutge... |
3N9B | Crystal Structure of the P. aeruginosa LigD phosphoesterase domain | Structure of bacterial LigD 3′-phosphoesterase
unveils a DNA repair superfamily
Pravin A. Nair, Paul Smith, and Stewart Shuman1
Molecular Biology Program, Sloan-Kettering Institute, New York, NY 10065
Edited by Stephen C. Kowalczykowski, University of California, Davis, CA, and approved May 28, 2010 (received for revie... |
3N9D | Monoclinic Structure of P. aeruginosa LigD phosphoesterase domain | Structure of bacterial LigD 3′-phosphoesterase
unveils a DNA repair superfamily
Pravin A. Nair, Paul Smith, and Stewart Shuman1
Molecular Biology Program, Sloan-Kettering Institute, New York, NY 10065
Edited by Stephen C. Kowalczykowski, University of California, Davis, CA, and approved May 28, 2010 (received for revie... |
3N9G | Crystal structure of the Fab fragment of the human neutralizing anti-West Nile Virus MAb CR4354 | Neutralization of West Nile virus by cross-linking
of its surface proteins with Fab fragments of
the human monoclonal antibody CR4354
Bärbel Kaufmanna, Matthew R. Vogtb, Jaap Goudsmitc, Heather A. Holdawaya, Anastasia A. Aksyuka, Paul R. Chipmana,
Richard J. Kuhna, Michael S. Diamondb,d,e, and Michael G. Rossmanna,1
aD... |
3N9H | Crystal Structural of mutant Y305A in the copper amine oxidase from hansenula polymorpha | Mutation at a Strictly-Conserved, Active-Site Tyrosine in the
Copper Amine Oxidase Leads to Uncontrolled Oxygenase
Activity†
Zhi-wei Chen*, Saumen Datta*,#, Jennifer L. DuBois‡,§, Judith P. Klinman‡,¶, and F. Scott
Mathews*,¶
*Department of Biochemistry and Molecular Biophysics, Washington University School of
Medicine... |
3N9R | Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(4-hydroxybutyl)-phosphoglycolohydroxamic acid, a competitive inhibitor | Rational design, synthesis and evaluation of new selective
inhibitors of microbial class II (zinc dependent) fructose bis-
phosphate aldolases
Racha Dahera,†, Mathieu Coinçonc,†, Matthieu Fonviellea, Petra M. Gestb, Marcelo E.
Guerinb,#, Mary Jacksonb, Jurgen Syguschc,*, and Michel Therisoda,*
aECBB, ICMMO, Univ Paris-... |
3N9S | Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(4-hydroxybutyl)- glycolohydroxamic acid bis-phosphate, a competitive inhibitor | Rational design, synthesis and evaluation of new selective
inhibitors of microbial class II (zinc dependent) fructose bis-
phosphate aldolases
Racha Dahera,†, Mathieu Coinçonc,†, Matthieu Fonviellea, Petra M. Gestb, Marcelo E.
Guerinb,#, Mary Jacksonb, Jurgen Syguschc,*, and Michel Therisoda,*
aECBB, ICMMO, Univ Paris-... |
3N9Y | Crystal structure of human CYP11A1 in complex with cholesterol | Structural basis for pregnenolone biosynthesis
by the mitochondrial monooxygenase system
Natallia Strushkevicha,1, Farrell MacKenziea, Tatyana Cherkesovab, Irina Grabovecb,
Sergey Usanovb, and Hee-Won Parka,c,1
aStructural Genomics Consortium, University of Toronto, 101 College Street, Toronto, ON, Canada M5G 1L7; bIns... |
3N9Z | Crystal structure of human CYP11A1 in complex with 22-hydroxycholesterol | Structural basis for pregnenolone biosynthesis
by the mitochondrial monooxygenase system
Natallia Strushkevicha,1, Farrell MacKenziea, Tatyana Cherkesovab, Irina Grabovecb,
Sergey Usanovb, and Hee-Won Parka,c,1
aStructural Genomics Consortium, University of Toronto, 101 College Street, Toronto, ON, Canada M5G 1L7; bIns... |
3NA0 | Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol | Structural basis for pregnenolone biosynthesis
by the mitochondrial monooxygenase system
Natallia Strushkevicha,1, Farrell MacKenziea, Tatyana Cherkesovab, Irina Grabovecb,
Sergey Usanovb, and Hee-Won Parka,c,1
aStructural Genomics Consortium, University of Toronto, 101 College Street, Toronto, ON, Canada M5G 1L7; bIns... |
3NA1 | Crystal structure of human CYP11A1 in complex with 20-hydroxycholesterol | Structural basis for pregnenolone biosynthesis
by the mitochondrial monooxygenase system
Natallia Strushkevicha,1, Farrell MacKenziea, Tatyana Cherkesovab, Irina Grabovecb,
Sergey Usanovb, and Hee-Won Parka,c,1
aStructural Genomics Consortium, University of Toronto, 101 College Street, Toronto, ON, Canada M5G 1L7; bIns... |
3NA5 | Crystal structure of a bacterial phosphoglucomutase, an enzyme important in the virulence of several human pathogens. | Crystal structure of a bacterial phosphoglucomutase, an enzyme
involved in the virulence of multiple human pathogens
Ritcha Mehra-Chaudhary1, Jacob Mick1, John J. Tanner2, Michael T. Henzl1, and Lesa J.
Beamer1,*
1Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, Missouri
65211
2Departm... |
3NAD | Crystal Structure of Phenolic Acid Decarboxylase from Bacillus pumilus UI-670 | structural communications
Acta Cryst. (2010). F66, 1407–1414
doi:10.1107/S174430911003246X
1407
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Structural analysis of Bacillus pumilus phenolic acid
decarboxylase, a lipocalin-fold enzyme
Allan Matte,a Stephan Grosse,... |
3NAE | RB69 DNA Polymerase (Y567A) Ternary Complex with dATP Opposite Guanidinohydantoin | Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows
dAMP and dGMP To Be Inserted Opposite Guanidinohydantoin†,,‡
Jeff Beckman‡, Mina Wang‡, Gregor Blaha, Jimin Wang*, and William H. Konigsberg*
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut
06520-8024
Abstract
Cont... |
3NAF | Structure of the Intracellular Gating Ring from the Human High-conductance Ca2+ gated K+ Channel (BK Channel) | Structure of the Gating Ring from the Human High-conductance
Ca2+-gated K+ Channel
Yunkun Wu1,2, Yi Yang1, Sheng Ye3, and Youxing Jiang1,2
1Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas
75390-9040
2Howard Hughes Medical Institute, University of Texas Southwestern Medical Cen... |
3NAL | SR Ca(2+)-ATPase in the HnE2 state complexed with the Thapsigargin derivative DTB | Critical Roles of Hydrophobicity and Orientation of Side
Chains for Inactivation of Sarcoplasmic Reticulum
Ca2-ATPase with Thapsigargin and Thapsigargin Analogs*□
S
Received for publication,April 20, 2010, and in revised form, June 2, 2010 Published, JBC Papers in Press,June 15, 2010, DOI 10.1074/jbc.M110.136242
Anne-... |
3NAM | SR Ca(2+)-ATPase in the HnE2 state complexed with the Thapsigargin derivative dOTg | Critical Roles of Hydrophobicity and Orientation of Side
Chains for Inactivation of Sarcoplasmic Reticulum
Ca2-ATPase with Thapsigargin and Thapsigargin Analogs*□
S
Received for publication,April 20, 2010, and in revised form, June 2, 2010 Published, JBC Papers in Press,June 15, 2010, DOI 10.1074/jbc.M110.136242
Anne-... |
3NAN | SR Ca(2+)-ATPase in the HnE2 state complexed with a Thapsigargin derivative Boc-(phi)Tg | Critical Roles of Hydrophobicity and Orientation of Side
Chains for Inactivation of Sarcoplasmic Reticulum
Ca2-ATPase with Thapsigargin and Thapsigargin Analogs*□
S
Received for publication,April 20, 2010, and in revised form, June 2, 2010 Published, JBC Papers in Press,June 15, 2010, DOI 10.1074/jbc.M110.136242
Anne-... |
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