protein_name stringlengths 4 4 | structure_title stringlengths 3 322 | main_text stringlengths 0 302k |
|---|---|---|
3MY2 | Crystal structure of LptC | Structure and Functional Analysis of LptC, a Conserved
Membrane Protein Involved in the Lipopolysaccharide Export
Pathway in Escherichia coli*□
S
Received for publication,May 13, 2010, and in revised form, July 13, 2010 Published, JBC Papers in Press,August 18, 2010, DOI 10.1074/jbc.M110.144709
An X. Tran‡1, Changjiang... |
3MYA | Crystal Structure of HP67 H41F - P61 | On Unsatisfied Hydrogen Bonds in the N-Terminal Subdomain of
Villin Headpiece
Jeffrey W. Brown1, Jeremiah D. Farelli1,2, and C. James McKnight1
1Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany
Street, W302, Boston, MA 02118
Abstract
Villin headpiece is a small, autonomously fol... |
3MYB | Crystal structure of enoyl-coa hydratase mycobacterium smegmatis | Increasing the Structural Coverage of Tuberculosis Drug Targets
Loren Baugha,b, Isabelle Phana,b, Darren W. Begleya,c, Matthew C. Cliftona,c, Brianna
Armoura,c, David M. Dranowa,c, Brandy M. Taylora,c, Marvin M. Muruthia,c, Jan
Abendrotha,c, James W. Fairmanc, David Fox IIIc, Shellie H. Dieterichc, Bart L. Stakera,b,... |
3MYC | Crystal Structure of HP67 H41F - P212121 | On Unsatisfied Hydrogen Bonds in the N-Terminal Subdomain of
Villin Headpiece
Jeffrey W. Brown1, Jeremiah D. Farelli1,2, and C. James McKnight1
1Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany
Street, W302, Boston, MA 02118
Abstract
Villin headpiece is a small, autonomously fol... |
3MYD | Structure of the Cytoplasmic domain of FlhA from Helicobacter pylori | Structure of the Cytoplasmic Domain of the Flagellar
Secretion Apparatus Component FlhA from
Helicobacter pylori*□
S
Received for publication,March 2, 2010, and in revised form, April 21, 2010 Published, JBC Papers in Press,May 4, 2010, DOI 10.1074/jbc.M110.119412
Stanley A. Moore1 and Yunhua Jia
From the Department of... |
3MYG | Aurora A Kinase complexed with SCH 1473759 | Published on Web Date: June 07, 2010
r 2010 American Chemical Society
214
DOI: 10.1021/ml100063w |ACS Med. Chem. Lett. 2010, 1, 214–218
pubs.acs.org/acsmedchemlett
Discovery of a Potent, Injectable Inhibitor of Aurora
Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core
Tao Yu,† Jayaram R. Tagat,*,† Angela D. Kerekes,† R... |
3MYH | Insights into the Importance of Hydrogen Bonding in the Gamma-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Ser236 | pubs.acs.org/Biochemistry
Published on Web 05/11/2010
r 2010 American Chemical Society
Biochemistry 2010, 49, 4897–4907
4897
DOI: 10.1021/bi1001344
Insights into the Importance of Hydrogen Bonding in the γ-Phosphate Binding
Pocket of Myosin: Structural and Functional Studies of Serine 236†,‡
Jeremiah J. Frye,§ Vadim A.... |
3MYI | Human metavinculin tail domain | A Helix Replacement Mechanism Directs Metavinculin
Functions
Erumbi S. Rangarajan, Jun Hyuck Lee, S. D. Yogesha, Tina Izard*
Cell Adhesion Laboratory, Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America
Abstract
Cells require distinct adhesion comple... |
3MYJ | Human Class I MHC HLA-A2 in complex with the WT-1 (126-134) (R1Y) peptide variant. | Structures of native and affinity-enhanced WT1 epitopes bound to
HLA-A*0201: implications for WT1-based cancer therapeutics
Oleg Y. Borbulevych1, Priscilla Do1, and Brian M. Baker1,2,*
1 Department of Chemistry and Biochemistry, 251, Nieuwland Science Hall, University of Notre
Dame, Notre Dame, IN 46556
2 Walther Cance... |
3MYK | Insights into the Importance of Hydrogen Bonding in the Gamma-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Ser236 | pubs.acs.org/Biochemistry
Published on Web 05/11/2010
r 2010 American Chemical Society
Biochemistry 2010, 49, 4897–4907
4897
DOI: 10.1021/bi1001344
Insights into the Importance of Hydrogen Bonding in the γ-Phosphate Binding
Pocket of Myosin: Structural and Functional Studies of Serine 236†,‡
Jeremiah J. Frye,§ Vadim A.... |
3MYL | Insights into the Importance of Hydrogen Bonding in the Gamma-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Ser236 | pubs.acs.org/Biochemistry
Published on Web 05/11/2010
r 2010 American Chemical Society
Biochemistry 2010, 49, 4897–4907
4897
DOI: 10.1021/bi1001344
Insights into the Importance of Hydrogen Bonding in the γ-Phosphate Binding
Pocket of Myosin: Structural and Functional Studies of Serine 236†,‡
Jeremiah J. Frye,§ Vadim A.... |
3MYM | Mutation of Methionine-86 in Dehaloperoxidase-hemoglobin: Effects of the Asp-His-Fe Triad in a 3/3 Globin | The Functional Consequences of the Creation of an Asp-His-Fe
Triad in a 3/3 Globin†,,‡
Edward L. D’Antonio, Jennifer D’Antonio, Vesna de Serrano, Hanna Gracz, Matthew K.
Thompson, Reza A. Ghiladi, Edmond F. Bowden*, and Stefan Franzen*
Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204
Abs... |
3MYN | Mutation of Methionine-86 in Dehaloperoxidase-hemoglobin: Effects of the Asp-His-Fe Triad in a 3/3 Globin | The Functional Consequences of the Creation of an Asp-His-Fe
Triad in a 3/3 Globin†,,‡
Edward L. D’Antonio, Jennifer D’Antonio, Vesna de Serrano, Hanna Gracz, Matthew K.
Thompson, Reza A. Ghiladi, Edmond F. Bowden*, and Stefan Franzen*
Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204
Abs... |
3MYU | Mycoplasma genitalium MG289 | Insights into Mycoplasma genitalium Metabolism Revealed by
the Structure of MG289, an Extracytoplasmic Thiamine Binding
Lipoprotein
Katherine H. Sippel1, Balasubramanian Venkatakrishnan1, Susan K. Boehlein2, Banumathi
Sankaran3, Jeanne G. Quirit1, Lakshamanan Govindasamy1, Mavis Agbandje-McKenna1,
Steve Goodison4,§, Ch... |
3MYY | Structure of E. Coli CheY mutant A113P bound to Beryllium fluoride | The role of position K+4 in phosphorylation and
dephosphorylation reaction kinetics of the CheY response
regulator
Clay A. Foster†,1, Ruth E. Silversmith, Robert M. Immormino†,2, Luke R. Vass†,3, Emily N.
Kennedy, Yael Pazy†,4, Edward J. Collins†,5, Robert B. Bourret*
Department of Microbiology and Immunology, Unive... |
3MYZ | Protein induced photophysical changes to the amyloid indicator dye, thioflavin T | Protein-induced photophysical changes to
the amyloid indicator dye thioflavin T
Leslie S. Wolfe1, Matthew F. Calabrese1, Abhinav Nath1, Dorottya V. Blaho, Andrew D. Miranker2, and Yong Xiong2
Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, CT 06520-8114
Edited by Jos... |
3MZ3 | Crystal structure of Co2+ HDAC8 complexed with M344 | Structures of Metal-Substituted Human Histone Deacetylase 8
Provide Mechanistic Inferences on Biological Function,†,‡
Daniel P. Dowling§, Samuel G. Gattis£, Carol A. Fierke£, and David W. Christianson§,*
§ Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania,
Philadelphia, PA 19104-63... |
3MZ4 | Crystal structure of D101L Mn2+ HDAC8 complexed with M344 | Structures of Metal-Substituted Human Histone Deacetylase 8
Provide Mechanistic Inferences on Biological Function,†,‡
Daniel P. Dowling§, Samuel G. Gattis£, Carol A. Fierke£, and David W. Christianson§,*
§ Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania,
Philadelphia, PA 19104-63... |
3MZ5 | Crystal structure of Staphylococcal nuclease variant Delta+PHS L103A at cryogenic temperature | Cavities determine the pressure unfolding of proteins
Julien Rochea,1, Jose A. Carob,1, Douglas R. Norbertoa,c, Philippe Barthea, Christian Roumestanda, Jamie L. Schlessmand,
Angel E. Garciae, Bertrand García-Moreno E.b, and Catherine A. Royera,2
aCentre de Biochimie Structurale, Institut National pour la Santé et la R... |
3MZ6 | Crystal structure of D101L Fe2+ HDAC8 complexed with M344 | Structures of Metal-Substituted Human Histone Deacetylase 8
Provide Mechanistic Inferences on Biological Function,†,‡
Daniel P. Dowling§, Samuel G. Gattis£, Carol A. Fierke£, and David W. Christianson§,*
§ Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania,
Philadelphia, PA 19104-63... |
3MZ7 | Crystal structure of D101L Co2+ HDAC8 complexed with M344 | Structures of Metal-Substituted Human Histone Deacetylase 8
Provide Mechanistic Inferences on Biological Function,†,‡
Daniel P. Dowling§, Samuel G. Gattis£, Carol A. Fierke£, and David W. Christianson§,*
§ Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania,
Philadelphia, PA 19104-63... |
3MZ8 | Crystal Structure of Zinc-Bound Natrin From Naja atra | Cobra CRISP Functions as an Inflammatory Modulator via a
Novel Zn2- and Heparan Sulfate-dependent Transcriptional
Regulation of Endothelial Cell Adhesion Molecules*
Received for publication,May 20, 2010, and in revised form, September 11, 2010 Published, JBC Papers in Press,October 2, 2010, DOI 10.1074/jbc.M110.146290... |
3MZD | Structure of penicillin-binding protein 5 from E. coli: cloxacillin acyl-enzyme complex | Crystal structures of covalent complexes of β-lactam antibiotics
with E. coli penicillin-binding protein 5: toward an understanding
of antibiotic specificity†
George Nicola1,§, Joshua Tomberg2, R. F. Pratt3, Robert A. Nicholas2, and Christopher
Davies1,*
1Department of Biochemistry, Medical University of South Carolina... |
3MZE | Structure of penicillin-binding protein 5 from E.coli: cefoxitin acyl-enzyme complex | Crystal structures of covalent complexes of β-lactam antibiotics
with E. coli penicillin-binding protein 5: toward an understanding
of antibiotic specificity†
George Nicola1,§, Joshua Tomberg2, R. F. Pratt3, Robert A. Nicholas2, and Christopher
Davies1,*
1Department of Biochemistry, Medical University of South Carolina... |
3MZF | Structure of penicillin-binding protein 5 from E. coli: imipenem acyl-enzyme complex | Crystal structures of covalent complexes of β-lactam antibiotics
with E. coli penicillin-binding protein 5: toward an understanding
of antibiotic specificity†
George Nicola1,§, Joshua Tomberg2, R. F. Pratt3, Robert A. Nicholas2, and Christopher
Davies1,*
1Department of Biochemistry, Medical University of South Carolina... |
3MZG | Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor | Two Independent Histidines, One in Human Prolactin and
One in Its Receptor, Are Critical for pH-dependent Receptor
Recognition and Activation*□
S
Received for publication,August 4, 2010, and in revised form, September 8, 2010 Published, JBC Papers in Press,September 30, 2010, DOI 10.1074/jbc.M110.172072
Mandar V. Kulka... |
3MZI | Crystallographic structure of the pseudo-Signaling State of the BLUF Photoreceptor PixD (slr1694) Y8F mutant | Mutational And Structural Studies Of The PixD BLUF Output
Signal That Affects Light-Regulated Interactions With PixE
Hua Yuan, Vladimira Dragnea, Qiong Wu, Kevin H. Gardner, and Carl E. Bauer*
Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405,
Department of Biochemistry, Unive... |
3MZK | Sec13/Sec16 complex, S.cerevisiae | JCB: Article
The Rockefeller University Press $30.00
J. Cell Biol. Vol. 190 No. 3 347–361
www.jcb.org/cgi/doi/10.1083/jcb.201003092
JCB
347
Correspondence to Thomas U. Schwartz: tus@mit.edu
Abbreviations used in this paper: CCD, central conserved domain; NE, nuclear
envelope; NPC, nuclear pore complex; PEG, polyeth... |
3MZL | Sec13/Sec31 edge element, loop deletion mutant | JCB: Article
The Rockefeller University Press $30.00
J. Cell Biol. Vol. 190 No. 3 347–361
www.jcb.org/cgi/doi/10.1083/jcb.201003092
JCB
347
Correspondence to Thomas U. Schwartz: tus@mit.edu
Abbreviations used in this paper: CCD, central conserved domain; NE, nuclear
envelope; NPC, nuclear pore complex; PEG, polyeth... |
3MZQ | RNase crystals grown by the hanging drop method | short communications
J. Appl. Cryst. (2010). 43, 1513–1518
doi:10.1107/S0021889810040409
1513
Journal of
Applied
Crystallography
ISSN 0021-8898
Received 5 June 2010
Accepted 8 October 2010
# 2010 International Union of Crystallography
Printed in Singapore – all rights reserved
Diffraction study of protein crystals grow... |
3MZR | RNase crystals grown in loops/micromounts | short communications
J. Appl. Cryst. (2010). 43, 1513–1518
doi:10.1107/S0021889810040409
1513
Journal of
Applied
Crystallography
ISSN 0021-8898
Received 5 June 2010
Accepted 8 October 2010
# 2010 International Union of Crystallography
Printed in Singapore – all rights reserved
Diffraction study of protein crystals grow... |
3MZS | Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol | Structural Basis for Three-step Sequential Catalysis by the
Cholesterol Side Chain Cleavage Enzyme CYP11A1*□
S
Received for publication,September24,2010,andinrevisedform,November24,2010 Published, JBC Papers in Press,December15,2010,DOI10.1074/jbc.M110.188433
Natalia Mast‡, Andrew J. Annalora§, David T. Lodowski¶, Krzy... |
3MZT | Protein-induced photophysical changes to the amyloid indicator dye, thioflavin T | Protein-induced photophysical changes to
the amyloid indicator dye thioflavin T
Leslie S. Wolfe1, Matthew F. Calabrese1, Abhinav Nath1, Dorottya V. Blaho, Andrew D. Miranker2, and Yong Xiong2
Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, CT 06520-8114
Edited by Jos... |
3MZV | Crystal structure of a decaprenyl diphosphate synthase from Rhodobacter capsulatus | Prediction of function for the polyprenyl transferase
subgroup in the isoprenoid synthase superfamily
Frank H. Wallrappa,b, Jian-Jung Panc, Gurusankar Ramamoorthyc, Daniel E. Almonacidb,d, Brandan S. Hilleriche,
Ronald Seidele, Yury Patskovskye, Patricia C. Babbittb,d, Steven C. Almoe, Matthew P. Jacobsona,b,1,
and C. ... |
3MZW | HER2 extracelluar region with affinity matured 3-helix affibody ZHER2:342 | Structural basis for high-affinity HER2 receptor
binding by an engineered protein
Charles Eigenbrota,b,1, Mark Ultscha, Anatoly Dubnovitskyc, Lars Abrahmsénd,1, and Torleif Härdc,1
aDepartment of Structural Biology and bDepartment of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080; cDepar... |
3N00 | Crystal Structure of a deletion mutant of human Reverba ligand binding domain bound with an NCoR ID1 peptide determined to 2.60A | Structural Analysis of Rev-erbα Bound to NCoR Reveals a
Unique Mechanism of Nuclear Receptor-Corepressor Interaction
Caroline A. Phelan1,*, Robert T. Gampe Jr.2,*, Millard H. Lambert2, Derek J. Parks3, Valerie
Montana2, Jane Bynum3, Timothy M. Broderick3, Xiao Hu1, Shawn P. Williams2, Robert T.
Nolte2,#, and Mitchell A... |
3N02 | Thaumatic crystals grown in loops/micromounts | short communications
J. Appl. Cryst. (2010). 43, 1513–1518
doi:10.1107/S0021889810040409
1513
Journal of
Applied
Crystallography
ISSN 0021-8898
Received 5 June 2010
Accepted 8 October 2010
# 2010 International Union of Crystallography
Printed in Singapore – all rights reserved
Diffraction study of protein crystals grow... |
3N03 | Thaumatin crystals grown from drops | short communications
J. Appl. Cryst. (2010). 43, 1513–1518
doi:10.1107/S0021889810040409
1513
Journal of
Applied
Crystallography
ISSN 0021-8898
Received 5 June 2010
Accepted 8 October 2010
# 2010 International Union of Crystallography
Printed in Singapore – all rights reserved
Diffraction study of protein crystals grow... |
3N06 | A mutant human Prolactin receptor antagonist H27A in complex with the extracellular domain of the human prolactin receptor | Two Independent Histidines, One in Human Prolactin and
One in Its Receptor, Are Critical for pH-dependent Receptor
Recognition and Activation*□
S
Received for publication,August 4, 2010, and in revised form, September 8, 2010 Published, JBC Papers in Press,September 30, 2010, DOI 10.1074/jbc.M110.172072
Mandar V. Kulka... |
3N07 | Structure of putative 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Vibrio cholerae | The Structural Basis for Divergence of Substrate Specificity and
Biological Function within HAD Phosphatases in
Lipopolysaccharide and Sialic Acid Biosynthesis
Kelly D. Daughtry†, Hua Huang§, Vladimir Malashkevich‡, Yury Patskovsky‡, Weifeng Liu‡,
Udupi Ramagopal‡, J. Michael Sauder‖, Stephen K. Burley‖,ˆ, Steven C. Al... |
3N0A | Crystal structure of auxilin (40-400) | Structure of the PTEN-like region of auxilin, a detector of
clathrin-coated vesicle budding
Rong Guan1, Dai Han3, Stephen C. Harrison3,4, and Tomas Kirchhausen1,2
1 Department of Cell Biology, Harvard Medical School, Boston, MA 02115
2 Immune Disease Institute and Program in Cellular and Molecular Medicine at Children'... |
3N0B | TM0449 mutant crystals grown in loops/micromounts | short communications
J. Appl. Cryst. (2010). 43, 1513–1518
doi:10.1107/S0021889810040409
1513
Journal of
Applied
Crystallography
ISSN 0021-8898
Received 5 June 2010
Accepted 8 October 2010
# 2010 International Union of Crystallography
Printed in Singapore – all rights reserved
Diffraction study of protein crystals grow... |
3N0C | TM0449 mutant crystal grown by hanging drop method | short communications
J. Appl. Cryst. (2010). 43, 1513–1518
doi:10.1107/S0021889810040409
1513
Journal of
Applied
Crystallography
ISSN 0021-8898
Received 5 June 2010
Accepted 8 October 2010
# 2010 International Union of Crystallography
Printed in Singapore – all rights reserved
Diffraction study of protein crystals grow... |
3N0F | Crystal Structure of Isoprene Synthase from Grey Poplar Leaves (Populus x canescens) | Structure of isoprene synthase illuminates the chemical
mechanism of teragram atmospheric carbon emission
Mustafa Köksal§, Ina Zimmer#, Jörg-Peter Schnitzler#, and David W. Christianson§,*
§ Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231
South 34th Street, Philadelphia, PA ... |
3N0G | Crystal Structure of Isoprene Synthase from Grey Poplar Leaves (Populus x canescens) in complex with three Mg2+ ions and dimethylallyl-S-thiolodiphosphate | Structure of isoprene synthase illuminates the chemical
mechanism of teragram atmospheric carbon emission
Mustafa Köksal§, Ina Zimmer#, Jörg-Peter Schnitzler#, and David W. Christianson§,*
§ Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231
South 34th Street, Philadelphia, PA ... |
3N0H | hDHFR double mutant Q35S/N64F Trimethoprim Binary Complex | Crystallographic Analysis Reveals a Novel Second Binding Site
for Trimethoprim in Active Site Double Mutants of Human
Dihydrofolate Reductase†,,‡
Vivian Cody*,§,∥, Jim Pace§, Jennifer Piraino§, and Sherry F. Queener⊥
§Structural Biology Department, Hauptman Woodward Medical Research Institute, 700 Ellicott St.
Buffalo,... |
3N0K | Proteinase inhibitor from Coprinopsis cinerea | Structural Basis of Trypsin Inhibition and Entomotoxicity of
Cospin, Serine Protease Inhibitor Involved in Defense of
Coprinopsis cinerea Fruiting Bodies*□
S
Received for publication,July 25, 2011, and in revised form, November 26, 2011 Published, JBC Papers in Press,December 14, 2011, DOI 10.1074/jbc.M111.285304
Jeric... |
3N0M | Crystal structure of BA2930 mutant (H183G) in complex with AcCoA | Structural analysis of a putative aminoglycoside N-
acetyltransferase from Bacillus anthracis
Maria M. Klimecka1,6, Maksymilian Chruszcz1,6, Jose Font1,6, Tatiana Skarina2,6, Igor
Shumilin1,6, Olena Onopryienko2,6, Przemyslaw J. Porebski1,6,7, Marcin Cymborowski1,6,
Matthew D. Zimmerman1,6, Jeremy Hasseman4,6, Ian J. G... |
3N0P | A mutant human Prolactin receptor antagonist H30A in complex with the extracellular domain of the human prolactin receptor | Two Independent Histidines, One in Human Prolactin and
One in Its Receptor, Are Critical for pH-dependent Receptor
Recognition and Activation*□
S
Received for publication,August 4, 2010, and in revised form, September 8, 2010 Published, JBC Papers in Press,September 30, 2010, DOI 10.1074/jbc.M110.172072
Mandar V. Kulka... |
3N0R | Structure of the PhyR stress response regulator at 1.25 Angstrom resolution | A structural model of anti-anti-σ inhibition by a two-component
receiver domain: the PhyR stress response regulator
Julien Herrou1, Robert Foreman2, Aretha Fiebig1, and Sean Crosson1,2,*
1 Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL,
USA
2 The Committee on Microbiology, The ... |
3N0S | Crystal structure of BA2930 mutant (H183A) in complex with AcCoA | Structural analysis of a putative aminoglycoside N-
acetyltransferase from Bacillus anthracis
Maria M. Klimecka1,6, Maksymilian Chruszcz1,6, Jose Font1,6, Tatiana Skarina2,6, Igor
Shumilin1,6, Olena Onopryienko2,6, Przemyslaw J. Porebski1,6,7, Marcin Cymborowski1,6,
Matthew D. Zimmerman1,6, Jeremy Hasseman4,6, Ian J. G... |
3N11 | Crystal stricture of wild-type chitinase from Bacillus cereus NCTU2 | Crystal Structures of Bacillus cereus NCTU2 Chitinase
Complexes with Chitooligomers Reveal Novel Substrate
Binding for Catalysis
A CHITINASE WITHOUT CHITIN BINDING AND INSERTION DOMAINS*□
S
Received for publication,June 3, 2010, and in revised form, July 27, 2010 Published, JBC Papers in Press,August 4, 2010, DOI 10.10... |
3N12 | Crystal stricture of chitinase in complex with zinc atoms from Bacillus cereus NCTU2 | Crystal Structures of Bacillus cereus NCTU2 Chitinase
Complexes with Chitooligomers Reveal Novel Substrate
Binding for Catalysis
A CHITINASE WITHOUT CHITIN BINDING AND INSERTION DOMAINS*□
S
Received for publication,June 3, 2010, and in revised form, July 27, 2010 Published, JBC Papers in Press,August 4, 2010, DOI 10.10... |
3N13 | Crystal stricture of D143A chitinase in complex with NAG from Bacillus cereus NCTU2 | Crystal Structures of Bacillus cereus NCTU2 Chitinase
Complexes with Chitooligomers Reveal Novel Substrate
Binding for Catalysis
A CHITINASE WITHOUT CHITIN BINDING AND INSERTION DOMAINS*□
S
Received for publication,June 3, 2010, and in revised form, July 27, 2010 Published, JBC Papers in Press,August 4, 2010, DOI 10.10... |
3N15 | Crystal stricture of E145Q chitinase in complex with NAG from Bacillus cereus NCTU2 | Crystal Structures of Bacillus cereus NCTU2 Chitinase
Complexes with Chitooligomers Reveal Novel Substrate
Binding for Catalysis
A CHITINASE WITHOUT CHITIN BINDING AND INSERTION DOMAINS*□
S
Received for publication,June 3, 2010, and in revised form, July 27, 2010 Published, JBC Papers in Press,August 4, 2010, DOI 10.10... |
3N17 | Crystal stricture of E145Q/Y227F chitinase in complex with NAG from Bacillus cereus NCTU2 | Crystal Structures of Bacillus cereus NCTU2 Chitinase
Complexes with Chitooligomers Reveal Novel Substrate
Binding for Catalysis
A CHITINASE WITHOUT CHITIN BINDING AND INSERTION DOMAINS*□
S
Received for publication,June 3, 2010, and in revised form, July 27, 2010 Published, JBC Papers in Press,August 4, 2010, DOI 10.10... |
3N18 | Crystal stricture of E145G/Y227F chitinase in complex with NAG from Bacillus cereus NCTU2 | Crystal Structures of Bacillus cereus NCTU2 Chitinase
Complexes with Chitooligomers Reveal Novel Substrate
Binding for Catalysis
A CHITINASE WITHOUT CHITIN BINDING AND INSERTION DOMAINS*□
S
Received for publication,June 3, 2010, and in revised form, July 27, 2010 Published, JBC Papers in Press,August 4, 2010, DOI 10.10... |
3N1A | Crystal stricture of E145G/Y227F chitinase in complex with cyclo-(L-His-L-Pro) from Bacillus cereus NCTU2 | Crystal Structures of Bacillus cereus NCTU2 Chitinase
Complexes with Chitooligomers Reveal Novel Substrate
Binding for Catalysis
A CHITINASE WITHOUT CHITIN BINDING AND INSERTION DOMAINS*□
S
Received for publication,June 3, 2010, and in revised form, July 27, 2010 Published, JBC Papers in Press,August 4, 2010, DOI 10.10... |
3N1B | C-terminal domain of Vps54 subunit of the GARP complex | Structural basis for the wobbler mouse neurodegenerative
disorder caused by mutation in the Vps54
subunit of the GARP complex
F. Javier Pérez-Victoriaa,1, Guillermo Abascal-Palaciosb,1, Igor Tascónb, Andrey Kajavac,
Javier G. Magadána, Erik P. Piorod, Juan S. Bonifacinoa,2, and Aitor Hierrob,2
aCell Biology and Metabol... |
3N1C | Crystal structure of the phosphofructokinase-2 from Escherichia coli in complex with fructose-6-phosphate | The Crystal Complex of Phosphofructokinase-2 of
Escherichia coli with Fructose-6-phosphate
KINETIC AND STRUCTURAL ANALYSIS OF THE ALLOSTERIC ATP INHIBITION*□
S
Received for publication,July 12, 2010, and in revised form, October 15, 2010 Published, JBC Papers in Press,December 8, 2010, DOI 10.1074/jbc.M110.163162
Ricar... |
3N1E | Vps54 C-terminal domain | Structural basis for the wobbler mouse neurodegenerative
disorder caused by mutation in the Vps54
subunit of the GARP complex
F. Javier Pérez-Victoriaa,1, Guillermo Abascal-Palaciosb,1, Igor Tascónb, Andrey Kajavac,
Javier G. Magadána, Erik P. Piorod, Juan S. Bonifacinoa,2, and Aitor Hierrob,2
aCell Biology and Metabol... |
3N1F | Crystal Structure of IhhN bound to CDOFn3 | All Mammalian Hedgehog Proteins Interact with Cell
Adhesion Molecule, Down-regulated by Oncogenes (CDO)
and Brother of CDO (BOC) in a Conserved Manner*□
S
Received for publication,April 7, 2010, and in revised form, May 24, 2010 Published, JBC Papers in Press,June 1, 2010, DOI 10.1074/jbc.M110.131680
Jennifer M. Kavran... |
3N1G | Crystal structure of DhhN bound to BOCFn3 | All Mammalian Hedgehog Proteins Interact with Cell
Adhesion Molecule, Down-regulated by Oncogenes (CDO)
and Brother of CDO (BOC) in a Conserved Manner*□
S
Received for publication,April 7, 2010, and in revised form, May 24, 2010 Published, JBC Papers in Press,June 1, 2010, DOI 10.1074/jbc.M110.131680
Jennifer M. Kavran... |
3N1M | Crystal Structure of IhhN bound to BOCFn3 | All Mammalian Hedgehog Proteins Interact with Cell
Adhesion Molecule, Down-regulated by Oncogenes (CDO)
and Brother of CDO (BOC) in a Conserved Manner*□
S
Received for publication,April 7, 2010, and in revised form, May 24, 2010 Published, JBC Papers in Press,June 1, 2010, DOI 10.1074/jbc.M110.131680
Jennifer M. Kavran... |
3N1O | Crystal structure of IhhN | All Mammalian Hedgehog Proteins Interact with Cell
Adhesion Molecule, Down-regulated by Oncogenes (CDO)
and Brother of CDO (BOC) in a Conserved Manner*□
S
Received for publication,April 7, 2010, and in revised form, May 24, 2010 Published, JBC Papers in Press,June 1, 2010, DOI 10.1074/jbc.M110.131680
Jennifer M. Kavran... |
3N1P | Crystal Structure of IhhN bound to BOCFn3 | All Mammalian Hedgehog Proteins Interact with Cell
Adhesion Molecule, Down-regulated by Oncogenes (CDO)
and Brother of CDO (BOC) in a Conserved Manner*□
S
Received for publication,April 7, 2010, and in revised form, May 24, 2010 Published, JBC Papers in Press,June 1, 2010, DOI 10.1074/jbc.M110.131680
Jennifer M. Kavran... |
3N1Q | Crystal Structure of DhhN bound to CDOFn3 | All Mammalian Hedgehog Proteins Interact with Cell
Adhesion Molecule, Down-regulated by Oncogenes (CDO)
and Brother of CDO (BOC) in a Conserved Manner*□
S
Received for publication,April 7, 2010, and in revised form, May 24, 2010 Published, JBC Papers in Press,June 1, 2010, DOI 10.1074/jbc.M110.131680
Jennifer M. Kavran... |
3N1X | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201C Mutant | Active Site Threonine Facilitates Proton Transfer During
Dioxygen Activation at the Diiron Center of Toluene/o-Xylene
Monooxygenase Hydroxylase
Woon Ju Song†, Michael S. McCormick†, Rachel K. Behan†, Matthew H. Sazinsky§, Wei
Jiang‡, Jeffery Lin§, Carsten Krebs‡, and Stephen J. Lippard†,*
† Department of Chemistry, Mas... |
3N1Y | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201G Mutant | Active Site Threonine Facilitates Proton Transfer During
Dioxygen Activation at the Diiron Center of Toluene/o-Xylene
Monooxygenase Hydroxylase
Woon Ju Song†, Michael S. McCormick†, Rachel K. Behan†, Matthew H. Sazinsky§, Wei
Jiang‡, Jeffery Lin§, Carsten Krebs‡, and Stephen J. Lippard†,*
† Department of Chemistry, Mas... |
3N1Z | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201S Mutant | Active Site Threonine Facilitates Proton Transfer During
Dioxygen Activation at the Diiron Center of Toluene/o-Xylene
Monooxygenase Hydroxylase
Woon Ju Song†, Michael S. McCormick†, Rachel K. Behan†, Matthew H. Sazinsky§, Wei
Jiang‡, Jeffery Lin§, Carsten Krebs‡, and Stephen J. Lippard†,*
† Department of Chemistry, Mas... |
3N20 | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201V Mutant | Active Site Threonine Facilitates Proton Transfer During
Dioxygen Activation at the Diiron Center of Toluene/o-Xylene
Monooxygenase Hydroxylase
Woon Ju Song†, Michael S. McCormick†, Rachel K. Behan†, Matthew H. Sazinsky§, Wei
Jiang‡, Jeffery Lin§, Carsten Krebs‡, and Stephen J. Lippard†,*
† Department of Chemistry, Mas... |
3N25 | The structure of muscle pyruvate kinase in complex with proline, pyruvate, and Mn2+ | PROTEIN STRUCTURE REPORT
The pyruvate kinase model system, a
cautionary tale for the use of osmolyte
perturbations to support conformational
equilibria in allostery
Aron W. Fenton,* Troy A. Johnson, and Todd Holyoak
Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, ... |
3N26 | Cpn0482 : the arginine binding protein from the periplasm of chlamydia Pneumoniae | Exploiting Antigenic Diversity for Vaccine Design
THE CHLAMYDIA ArtJ PARADIGM*□
S
Received for publication,February 26, 2010, and in revised form, May 18, 2010 Published, JBC Papers in Press,June 30, 2010, DOI 10.1074/jbc.M110.118513
Marco Soriani‡, Pierre Petit§, Renata Grifantini‡1, Roberto Petracca‡, Giovanni Gancit... |
3N29 | Crystal structure of carboxynorspermidine decarboxylase complexed with Norspermidine from Campylobacter jejuni | Evolution of Substrate Specificity within a Diverse Family of
/-Barrel-fold Basic Amino Acid Decarboxylases
X-RAY STRUCTURE DETERMINATION OF ENZYMES WITH SPECIFICITY FOR L-ARGININE
AND CARBOXYNORSPERMIDINE*□
S
Received for publication,March 8, 2010, and in revised form, April 14, 2010 Published, JBC Papers in Press,J... |
3N2C | Crystal structure of prolidase eah89906 complexed with n-methylphosphonate-l-proline | Functional Identification and Structure Determination of Two
Novel Prolidases from cog1228 in the Amidohydrolase
Superfamily
Dao Feng Xiang‡, Yury PatskovskyΨ, Chengfu Xu‡, Alexander A. FedorovΨ, Elena V.
FedorovΨ, Abby A. Sisco‡, J. Michael Sauder§, Stephen K. Burley§, Steven C. AlmoΨ,*, and
Frank M. Raushel‡,*
‡Depar... |
3N2E | Crystal structure of Helicobactor pylori shikimate kinase in complex with NSC162535 | Structures of Helicobacter pylori Shikimate Kinase
Reveal a Selective Inhibitor-Induced-Fit Mechanism
Wen-Chi Cheng1,2., Yen-Fu Chen3., Hung-Jung Wang1,2, Kai-Cheng Hsu3, Shuang-Chih Lin1, Tzu-Jung
Chen1, Jinn-Moon Yang3,4*, Wen-Ching Wang1,2*
1 Institute of Molecular and Cellular Biology and Department of Life Science... |
3N2G | TUBULIN-NSC 613863: RB3 Stathmin-like domain complex | Stathmin and Interfacial Microtubule Inhibitors Recognize a
Naturally Curved Conformation of Tubulin Dimers*□
S
Received for publication,May 19, 2010, and in revised form, July 15, 2010 Published, JBC Papers in Press,July 30, 2010, DOI 10.1074/jbc.M110.141929
Pascale Barbier‡1, Audrey Dorle´ans§2, Francois Devred‡, Lau... |
3N2K | TUBULIN-NSC 613862: RB3 Stathmin-like domain complex | Stathmin and Interfacial Microtubule Inhibitors Recognize a
Naturally Curved Conformation of Tubulin Dimers*□
S
Received for publication,May 19, 2010, and in revised form, July 15, 2010 Published, JBC Papers in Press,July 30, 2010, DOI 10.1074/jbc.M110.141929
Pascale Barbier‡1, Audrey Dorle´ans§2, Francois Devred‡, Lau... |
3N2N | The Crystal Structure of Tumor Endothelial Marker 8 (TEM8) extracellular domain | The Structure of Tumor Endothelial Marker 8 (TEM8)
Extracellular Domain and Implications for Its Receptor
Function for Recognizing Anthrax Toxin
Sheng Fu1,2., Xiaohang Tong1,2., Chenguang Cai3, Ying Zhao2, Yang Wu1,2, Yuanyuan Li1,2, Junjie Xu3,
Xuejun C. Zhang1, Long Xu4, Wei Chen3*, Zihe Rao1,2,5*
1 National Laborato... |
3N2O | X-ray crystal structure of arginine decarboxylase complexed with Arginine from Vibrio vulnificus | Evolution of Substrate Specificity within a Diverse Family of
/-Barrel-fold Basic Amino Acid Decarboxylases
X-RAY STRUCTURE DETERMINATION OF ENZYMES WITH SPECIFICITY FOR L-ARGININE
AND CARBOXYNORSPERMIDINE*□
S
Received for publication,March 8, 2010, and in revised form, April 14, 2010 Published, JBC Papers in Press,J... |
3N2R | Structure of neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R/3S,4S)-4-(3-Phenoxyphenoxy)pyrrolidin-3-yl)methyl)pyridin-2-amine | Structure-based design, synthesis, and biological evaluation of
lipophilic-tailed monocationic inhibitors of neuronal nitric oxide
synthase
Fengtian Xue1,5,6, Jinwen Huang1,5, Haitao Ji1, Jianguo Fang1, Huiying Li2, Pavel
Martásek3,4, Linda J. Roman3, Thomas L. Poulos2,*, and Richard B. Silverman1,*
1 Department of Che... |
3N2Y | Crystal structure of tyrosyl-tRNA synthetase complexed with p-(2-tetrazolyl)-phenylalanine | A Biosynthetic Route to Photoclick Chemistry on Protein
Jiangyun Wang1,*, Wei Zhang1, Wenjiao Song2, Yizhong Wang2, Zhipeng Yu2, Jiasong Li3,
Minhao Wu3, Lin Wang3, Jianye Zang3, and Qing Lin2,*
1 National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of
Sciences, Beijing 100101, China
2... |
3N2Z | The Structure of Human Prolylcarboxypeptidase at 2.80 Angstroms Resolution | Soisson et al. BMC Structural Biology 2010, 10:16
http://www.biomedcentral.com/1472-6807/10/16
Open Access
RESEARCH ARTICLE
© 2010 Soisson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.... |
3N37 | Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli | Structural Basis for Activation of Class Ib Ribonucleotide
Reductase
Amie K. Boal1, Joseph A. Cotruvo Jr.2, JoAnne Stubbe2,3,*, and Amy C. Rosenzweig1,*
1Departments of Biochemistry, Molecular Biology and Cell Biology, and Chemistry, Northwestern
University, Evanston, IL 60208, USA
2Department of Chemistry, Massachuset... |
3N38 | Ribonucleotide Reductase NrdF from Escherichia coli Soaked with Ferrous Ions | Structural Basis for Activation of Class Ib Ribonucleotide
Reductase
Amie K. Boal1, Joseph A. Cotruvo Jr.2, JoAnne Stubbe2,3,*, and Amy C. Rosenzweig1,*
1Departments of Biochemistry, Molecular Biology and Cell Biology, and Chemistry, Northwestern
University, Evanston, IL 60208, USA
2Department of Chemistry, Massachuset... |
3N39 | Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli in Complex with NrdI | Structural Basis for Activation of Class Ib Ribonucleotide
Reductase
Amie K. Boal1, Joseph A. Cotruvo Jr.2, JoAnne Stubbe2,3,*, and Amy C. Rosenzweig1,*
1Departments of Biochemistry, Molecular Biology and Cell Biology, and Chemistry, Northwestern
University, Evanston, IL 60208, USA
2Department of Chemistry, Massachuset... |
3N3A | Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli in Complex with Reduced NrdI | Structural Basis for Activation of Class Ib Ribonucleotide
Reductase
Amie K. Boal1, Joseph A. Cotruvo Jr.2, JoAnne Stubbe2,3,*, and Amy C. Rosenzweig1,*
1Departments of Biochemistry, Molecular Biology and Cell Biology, and Chemistry, Northwestern
University, Evanston, IL 60208, USA
2Department of Chemistry, Massachuset... |
3N3B | Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli in Complex with Reduced NrdI with a Trapped Peroxide | Structural Basis for Activation of Class Ib Ribonucleotide
Reductase
Amie K. Boal1, Joseph A. Cotruvo Jr.2, JoAnne Stubbe2,3,*, and Amy C. Rosenzweig1,*
1Departments of Biochemistry, Molecular Biology and Cell Biology, and Chemistry, Northwestern
University, Evanston, IL 60208, USA
2Department of Chemistry, Massachuset... |
3N3E | Zebrafish AlphaA crystallin | PROTEIN STRUCTURE REPORT
Non-3D domain swapped crystal structure
of truncated zebrafish alphaA crystallin
A. Laganowsky1,2,3 and D. Eisenberg1,2,3*
1UCLA-DOE, Institute for Genomics and Proteomics, Los Angeles, California
2Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, Cali... |
3N3F | Crystal Structure of the Human Collagen XV Trimerization Domain: A Potent Trimerizing Unit Common to Multiplexin Collagens | Crystal Structure of the Human Collagen XV Trimerization
Domain: A Potent Trimerizing Unit Common to Multiplexin
Collagens
Jacqueline A. Wirza,b, Sergei P. Boudkoa,b, Thomas F. Lerchb, Michael S. Chapmanb, and
Hans Peter Bächingera,b,*
a Research Department of Shriners Hospital for Children, 3101 SW Sam Jackson Pk. Rd.... |
3N3K | The catalytic domain of USP8 in complex with a USP8 specific inhibitor | A Strategy for Modulation of Enzymes in the Ubiquitin System
Andreas Ernst1, George Avvakumov2, Jiefei Tong3, Yihui Fan4, Yanling Zhao4, Philipp
Alberts3, Avinash Persaud3,5, John R Walker2, Ana-Mirela Neculai1, Dante Neculai2,
Andrew Vorobyov1, Pankaj Garg1, Linda Beatty1, Pak-Kei Chan6, Yu-Chi Juang7, Marie-
Claude L... |
3N3T | Crystal structure of putative diguanylate cyclase/phosphodiesterase complex with cyclic di-gmp | Structural insight into the mechanism of cyclic di-GMP
hydrolysis by EAL domain phosphodiesterases
Anatoli Tchigvintsev1,5, Xiaohui Xu1,5, Alexander Singer1, Changsoo Chang2, Greg
Brown1, Michael Proudfoot1, Hong Cui1, Robert Flick1, Wayne F. Anderson3, Andrzej
Joachimiak2, Michael Y. Galperin4, Alexei Savchenko1, and ... |
3N3U | Crystal Structure of IbpAFic2 | Structural basis of Fic mediated adenylylation
Junyu Xiao1, Carolyn A. Worby1,2,3, Seema Mattoo4, Banumathi Sankaran5, and Jack E.
Dixon1,2,3,4
1Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
2Department of Cellular and Molecular Medicine, University of California, San Diego, ... |
3N4I | Crystal structure of the SHV-1 D104E beta-lactamase/beta-lactamase inhibitor protein (BLIP) complex | Specificity and Cooperativity at β-lactamase Position 104 in
TEM-1/BLIP and SHV-1/BLIP interactions
Melinda S. Hanes1,2, Kimberly A. Reynolds1,2,7, Case McNamara3, Partho Ghosh3, Robert
A. Bonomo4,5, Jack F. Kirsch6, and Tracy M. Handel2
1Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94729... |
3N4M | E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA | RNA polymerase alpha subunit recognizes the DNA shape of the
Upstream Promoter element
Samuel Lara-Gonzalez1,§, Ana Carolina Dantas Machado2,§, Satyanarayan Rao2,§, Andrew
A. Napoli1, Jens Birktoft1, Rosa Di Felice2,3,4, Remo Rohs2,3,5,6,*, Catherine L. Lawson1,7,*
1Department of Chemistry and Chemical Biology, Rutge... |
3N4N | Insights into the stabilizing contributions of a bicyclic cytosine analogue: crystal structures of DNA duplexes containing 7,8-dihydropyrido[2,3-d]pyrimidin-2-one | Insights into the DNA stabilizing contributions of a
bicyclic cytosine analogue: crystal structures of
DNA duplexes containing 7,8-dihydropyrido
[2,3-d]pyrimidin-2-one
Ella Czarina Magat Juan1, Satoru Shimizu1, Xiao Ma1, Taizo Kurose1,
Tsuyoshi Haraguchi1, Fang Zhang2, Masaru Tsunoda2, Akihiro Ohkubo1,
Mitsuo Sekine1, ... |
3N4O | Insights into the stabilizing contributions of a bicyclic cytosine analogue: crystal structures of DNA duplexes containing 7,8-dihydropyrido[2,3-d]pyrimidin-2-one | Insights into the DNA stabilizing contributions of a
bicyclic cytosine analogue: crystal structures of
DNA duplexes containing 7,8-dihydropyrido
[2,3-d]pyrimidin-2-one
Ella Czarina Magat Juan1, Satoru Shimizu1, Xiao Ma1, Taizo Kurose1,
Tsuyoshi Haraguchi1, Fang Zhang2, Masaru Tsunoda2, Akihiro Ohkubo1,
Mitsuo Sekine1, ... |
3N4P | Human cytomegalovirus terminase nuclease domain | Structure and inhibition of herpesvirus DNA
packaging terminase nuclease domain
Marta Nadala,b, Philippe J. Masc, Alexandre G. Blancoa,b, Carme Arnana,b, Maria Solàb, Darren J. Hartc, and Miquel Colla,b,1
aInstitute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain; bInstitu... |
3N4Q | Human cytomegalovirus terminase nuclease domain, Mn soaked | Structure and inhibition of herpesvirus DNA
packaging terminase nuclease domain
Marta Nadala,b, Philippe J. Masc, Alexandre G. Blancoa,b, Carme Arnana,b, Maria Solàb, Darren J. Hartc, and Miquel Colla,b,1
aInstitute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain; bInstitu... |
3N4R | Structure of Csm1 C-terminal domain, R3 form | The monopolin complex cross-links kinetochore components to
regulate chromosome-microtubule attachments
Kevin D. Corbett1, Calvin K. Yip2, Ly-Sha Ee3, Thomas Walz2,4, Angelika Amon3,4, and
Stephen C. Harrison1,4,*
1 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250
Longwood Aven... |
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