protein_name stringlengths 4 4 | structure_title stringlengths 3 322 | main_text stringlengths 0 302k |
|---|---|---|
3MQB | Crystal Structure of Ectodomain of BST-2/Tetherin/CD317 (C2) | Structural insight into the mechanisms of
enveloped virus tethering by tetherin
Haitao Yanga,1, Jimin Wanga,1, Xiaofei Jiaa, Matthew W. McNattb, Trinity Zangb, Baocheng Pana, Wuyi Menga,
Hong-Wei Wanga, Paul D. Bieniaszb, and Yong Xionga,2
aDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven... |
3MQC | Crystal Structure of Ectodomain of BST-2/Tetherin/CD317 (P21) | Structural insight into the mechanisms of
enveloped virus tethering by tetherin
Haitao Yanga,1, Jimin Wanga,1, Xiaofei Jiaa, Matthew W. McNattb, Trinity Zangb, Baocheng Pana, Wuyi Menga,
Hong-Wei Wanga, Paul D. Bieniaszb, and Yong Xionga,2
aDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven... |
3MQD | Crystal structure of beta-ketoacyl synthase from brucella melitensis with FOL 0758, (1-methyl-1h-indazol-3-yl) methanol | Structural characterization of β-ketoacyl ACP synthase I bound
to platencin and fragment screening molecules at two substrate
binding sites
Edward I. Patterson1, Jeffrey D. Nanson2,3, Jan Abendroth4,5, Cassie Bryan4,6, Banumathi
Sankaran7, Peter J. Myler4,8, Jade K. Forwood9
1Department of Pathology, University of T... |
3MQG | crystal structure of the 3-N-acetyl transferase WlbB from Bordetella petrii in complex with acetyl-CoA | Molecular Structure of WlbB, a Bacterial N-Acetyltransferase
Involved in the Biosynthesis of 2,3-Diacetamido-2,3-Dideoxy-D-
Mannuronic Acid
James B. Thoden and Hazel M. Holden*
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706
Abstract
The pathogenic bacteria Pseudomonas aeruginosa and Borde... |
3MQH | crystal structure of the 3-N-acetyl transferase WlbB from Bordetella petrii in complex with CoA and UDP-3-amino-2-acetamido-2,3-dideoxy glucuronic acid | Molecular Structure of WlbB, a Bacterial N-Acetyltransferase
Involved in the Biosynthesis of 2,3-Diacetamido-2,3-Dideoxy-D-
Mannuronic Acid
James B. Thoden and Hazel M. Holden*
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706
Abstract
The pathogenic bacteria Pseudomonas aeruginosa and Borde... |
3MQI | Human early B-cell factor 1 (EBF1) IPT/TIG domain | Structural Determination of
Functional Domains in Early
B-cell Factor (EBF) Family of
Transcription Factors Reveals
Similarities to Rel DNA-binding
Proteins and a Novel
Dimerization Motif*□
S
Received for publication,June 2, 2010, and in revised form, June 16, 2010
Published, JBC Papers in Press,June 30, 2010, DOI 10.1... |
3MQK | Cbf5-Nop10-Gar1 complex binding with 17mer RNA containing ACA trinucleotide | Structural and functional evidence of high specificity
of Cbf5 for ACA trinucleotide
JING ZHOU,1 BO LIANG,2 and HONG LI1,2
1Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, USA
2Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA
AB... |
3MQL | Crystal structure of the fibronectin 6FnI1-2FnII7FnI fragment | Implications for Collagen Binding from the Crystallographic
Structure of Fibronectin 6FnI1–2FnII7FnI
□
S
Received for publication,May 3, 2010, and in revised form, August 5, 2010 Published, JBC Papers in Press,August 24, 2010, DOI 10.1074/jbc.M110.139394
Miche`le C. Erat‡1, Ulrich Schwarz-Linek§, Andrew R. Pickford¶2, ... |
3MQM | Crystal Structure of the Bromodomain of human ASH1L | Resource
Histone Recognition and Large-Scale
Structural Analysis of the Human
Bromodomain Family
Panagis Filippakopoulos,1,* Sarah Picaud,1 Maria Mangos,3 Tracy Keates,1 Jean-Philippe Lambert,5
Dalia Barsyte-Lovejoy,3 Ildiko Felletar,1 Rudolf Volkmer,6 Susanne Mu¨ ller,1 Tony Pawson,5,7 Anne-Claude Gingras,5,7
Cheryl H... |
3MQY | SgrAI with cleaved DNA and Magnesium bound | research papers
Acta Cryst. (2011). D67, 67–74
doi:10.1107/S0907444910047785
67
Acta Crystallographica Section D
Biological
Crystallography
ISSN 0907-4449
New clues in the allosteric activation of DNA
cleavage by SgrAI: structures of SgrAI bound to
cleaved primary-site DNA and uncleaved
secondary-site DNA
Elizabeth J. ... |
3MR1 | Crystal structure of methionine aminopeptidase from Rickettsia prowazekii | Rickettsia prowazekii Methionine Aminopeptidase as a
Promising Target for the Development of Antibacterial Agents
Travis R. Helgren†, Congling Chen†, Phumvadee Wangtrakuldee†, Thomas E. Edwards‡,
Bart L. Staker₴,Δ, Jan Abendroth‡, Banumathi SankaranⱵ, Nicole A. Housleyǁ, Peter J. Myler
$,Δ,₸, Jonathon P. Audiaǁ, Jame... |
3MR2 | Human DNA polymerase eta in complex with normal DNA and incoming nucleotide (Nrm) | Structure and Mechanism of Human DNA Polymerase η
Christian Biertümpfel1, Ye Zhao2,1, Yuji Kondo3, Santiago Ramón-Maiques1,6, Mark
Gregory1, Jae Young Lee1,7, Chikahide Masutani3, Alan R. Lehmann5, Fumio Hanaoka3,4,
and Wei Yang1
1Laboratory of Molecular Biology, NIDDK, NIH
2Institute of Nuclear-Agricultural Sciences... |
3MR3 | Human DNA polymerase eta - DNA ternary complex with the 3'T of a CPD in the active site (TT1) | Structure and Mechanism of Human DNA Polymerase η
Christian Biertümpfel1, Ye Zhao2,1, Yuji Kondo3, Santiago Ramón-Maiques1,6, Mark
Gregory1, Jae Young Lee1,7, Chikahide Masutani3, Alan R. Lehmann5, Fumio Hanaoka3,4,
and Wei Yang1
1Laboratory of Molecular Biology, NIDDK, NIH
2Institute of Nuclear-Agricultural Sciences... |
3MR5 | Human DNA polymerase eta - DNA ternary complex with a CPD 1bp upstream of the active site (TT3) | Structure and Mechanism of Human DNA Polymerase η
Christian Biertümpfel1, Ye Zhao2,1, Yuji Kondo3, Santiago Ramón-Maiques1,6, Mark
Gregory1, Jae Young Lee1,7, Chikahide Masutani3, Alan R. Lehmann5, Fumio Hanaoka3,4,
and Wei Yang1
1Laboratory of Molecular Biology, NIDDK, NIH
2Institute of Nuclear-Agricultural Sciences... |
3MR6 | Human DNA polymerase eta - DNA ternary complex with a CPD 2bp upstream of the active site (TT4) | Structure and Mechanism of Human DNA Polymerase η
Christian Biertümpfel1, Ye Zhao2,1, Yuji Kondo3, Santiago Ramón-Maiques1,6, Mark
Gregory1, Jae Young Lee1,7, Chikahide Masutani3, Alan R. Lehmann5, Fumio Hanaoka3,4,
and Wei Yang1
1Laboratory of Molecular Biology, NIDDK, NIH
2Institute of Nuclear-Agricultural Sciences... |
3MRS | Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori | Structures of Helicobacter pylori Shikimate Kinase
Reveal a Selective Inhibitor-Induced-Fit Mechanism
Wen-Chi Cheng1,2., Yen-Fu Chen3., Hung-Jung Wang1,2, Kai-Cheng Hsu3, Shuang-Chih Lin1, Tzu-Jung
Chen1, Jinn-Moon Yang3,4*, Wen-Ching Wang1,2*
1 Institute of Molecular and Cellular Biology and Department of Life Science... |
3MRU | Crystal Structure of Aminoacylhistidine Dipeptidase from Vibrio alginolyticus | Crystal Structure and Mutational Analysis of
Aminoacylhistidine Dipeptidase from Vibrio alginolyticus
Reveal a New Architecture of M20 Metallopeptidases*□
S
Received for publication,May 1, 2010, and in revised form, August 16, 2010 Published, JBC Papers in Press,September 6, 2010, DOI 10.1074/jbc.M110.139683
Chin-Yuan ... |
3MSV | The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor | The hypoxic regulator of sterol synthesis Nro1 is a nuclear
import adaptor
Tzu-Lan Yeh*,1, Chih-Yung S. Lee*,2, L. Mario Amzel1, Peter J. Espenshade2,§, and Mario A.
Bianchet1,§
1Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of
Medicine, 725 N Wolfe St., Baltimore, Maryland USA
2De... |
3MSW | Crystal structure of a Protein with unknown function (BF3112) from Bacteroides fragilis NCTC 9343 at 1.90 A resolution | A R T I C L E
Structures of single-layer β-sheet proteins evolved
from β-hairpin repeats
Qingping Xu1,2,3
|
Matthew Biancalana4
|
Joanna C. Grant1
|
Hsiu-Ju Chiu1,2
|
Lukasz Jaroszewski1,5,6,7
|
Mark W. Knuth1,8
|
Scott A. Lesley1,8,9,10
|
Adam Godzik1,5,6,7
|
Marc-André Elsliger1,9
|
Ashley M. Deacon1,2,11
|
Ian A. Wi... |
3MT5 | Crystal Structure of the Human BK Gating Apparatus | Structure of the Human BK Channel Ca2+-Activation Apparatus at
3.0 Å Resolution
Peng Yuan, Manuel D. Leonetti, Alexander R. Pico*, Yichun Hsiung, and Roderick
MacKinnon†
Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes
Medical Institute, 1230 York Avenue, New York, NY 10065, US... |
3MT6 | Structure of ClpP from Escherichia coli in complex with ADEP1 | Acyldepsipeptide Antibiotics Induces the Formation of a
Structured Axial Channel in ClpP: a Model for the ClpX/ClpA
Bound State of ClpP
Dominic Him Shun Li1,2,#, Yu Seon Chung1,#, Melanie Gloyd1,#, Ebenezer Joseph3,#,
Rodolfo Ghirlando4, Gerard D. Wright1,2, Yi-Qiang Cheng5, Michael R. Maurizi3, Alba
Guarné1, and Joaqu... |
3MTE | Crystal Structure of 16S rRNA Methyltranferase | Structural insights into the function of
aminoglycoside-resistance A1408 16S rRNA
methyltransferases from antibiotic-producing
and human pathogenic bacteria
Rachel Macmaster1,2, Natalia Zelinskaya1, Miloje Savic1, C. Robert Rankin1 and
Graeme L. Conn1,*
1Department of Biochemistry, Emory University School of Medicine, ... |
3MTF | Crystal structure of the ACVR1 kinase in complex with a 2-aminopyridine inhibitor | A New Class of Small Molecule Inhibitor of BMP Signaling
Caroline E. Sanvitale1, Georgina Kerr1, Apirat Chaikuad1, Marie-Christine Ramel2, Agustin H. Mohedas3,
Sabine Reichert2, You Wang4, James T. Triffitt5, Gregory D. Cuny4¤, Paul B. Yu3, Caroline S. Hill2,
Alex N. Bullock1*
1 Structural Genomics Consortium, Universi... |
3MTL | Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804 | Research Article
Structure and inhibitor specificity of the
PCTAIRE-family kinase CDK16
Sarah E. Dixon-Clarke1, Saifeldin N. Shehata2,3, Tobias Krojer1, Timothy D. Sharpe1,*, Frank von Delft1,4,5,
Kei Sakamoto2,3 and Alex N. Bullock1
1Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Driv... |
3MTN | Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor | A Strategy for Modulation of Enzymes in the Ubiquitin System
Andreas Ernst1, George Avvakumov2, Jiefei Tong3, Yihui Fan4, Yanling Zhao4, Philipp
Alberts3, Avinash Persaud3,5, John R Walker2, Ana-Mirela Neculai1, Dante Neculai2,
Andrew Vorobyov1, Pankaj Garg1, Linda Beatty1, Pak-Kei Chan6, Yu-Chi Juang7, Marie-
Claude L... |
3MTR | Crystal structure of the Ig5-FN1 tandem of human NCAM | Structure and Mutagenesis of Neural Cell Adhesion Molecule
Domains
EVIDENCEFORFLEXIBILITYINTHEPLACEMENTOFPOLYSIALICACIDATTACHMENTSITES*□
S
Received for publication,April 30, 2010, and in revised form, June 8, 2010 Published, JBC Papers in Press,June 23, 2010, DOI 10.1074/jbc.M110.140038
Deirdre A. Foley, Kristin G. Swa... |
3MTS | Chromo Domain of Human Histone-Lysine N-Methyltransferase SUV39H1 | Crystal Structure of the Human SUV39H1 Chromodomain
and Its Recognition of Histone H3K9me2/3
Tao Wang1., Chao Xu2., Yanli Liu2,3, Kai Fan1, Zhihong Li2, Xing Sun2, Hui Ouyang2, Xuecheng Zhang4,
Jiahai Zhang1, Yanjun Li2, Farrell MacKenzie2, Jinrong Min2,3*, Xiaoming Tu1*
1 Hefei National Laboratory for Physical Science... |
3MTT | Crystal structure of iSH2 domain of human p85beta, Northeast Structural Genomics Consortium Target HR5531C | structural communications
Acta Cryst. (2010). F66, 1567–1571
doi:10.1107/S1744309110041333
1567
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Structure of the iSH2 domain of human
phosphatidylinositol 3-kinase p85b subunit reveals
conformational plasticity in the ... |
3MTU | Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle | Structure of the Tropomyosin Overlap Complex from Chicken
Smooth Muscle: Insight into the Diversity of N-Terminus
Recognition†,‡
Jeremiah Frye, Vadim A. Klenchin, and Ivan Rayment*
Department of Biochemistry, University of Wisconsin, Madison, U.S.A
Abstract
Tropomyosin is a stereotypical α-helical coiled-coil that poly... |
3MTV | The Crystal Structure of the PRRSV Nonstructural Protein Nsp1 | JOURNAL OF VIROLOGY, July 2010, p. 6461–6471
Vol. 84, No. 13
0022-538X/10/$12.00
doi:10.1128/JVI.00301-10
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
The Crystal Structure of Porcine Reproductive and Respiratory
Syndrome Virus Nonstructural Protein Nsp1 Reveals
a Novel Metal-Dependent Nuc... |
3MTW | Crystal structure of L-Lysine, L-Arginine carboxypeptidase Cc2672 from Caulobacter Crescentus CB15 complexed with N-methyl phosphonate derivative of L-Arginine | Functional Identification and Structure Determination of Two
Novel Prolidases from cog1228 in the Amidohydrolase
Superfamily
Dao Feng Xiang‡, Yury PatskovskyΨ, Chengfu Xu‡, Alexander A. FedorovΨ, Elena V.
FedorovΨ, Abby A. Sisco‡, J. Michael Sauder§, Stephen K. Burley§, Steven C. AlmoΨ,*, and
Frank M. Raushel‡,*
‡Depar... |
3MTX | Crystal structure of chicken MD-1 | Crystal structure of soluble MD-1 and its interaction
with lipid IVa
Sung-il Yoona, Minsun Honga, Gye Won Hana,b, and Ian A. Wilsona,b,1
aDepartment of Molecular Biology and bSkaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037
Edited* by David R. Davies, National Institute of Diabe... |
3MU3 | Crystal structure of chicken MD-1 complexed with lipid IVa | Crystal structure of soluble MD-1 and its interaction
with lipid IVa
Sung-il Yoona, Minsun Honga, Gye Won Hana,b, and Ian A. Wilsona,b,1
aDepartment of Molecular Biology and bSkaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037
Edited* by David R. Davies, National Institute of Diabe... |
3MU6 | Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules | Inhibition of the function of class IIa HDACs by
blocking their interaction with MEF2
Nimanthi Jayathilaka1,2,*, Aidong Han1, Kevin J. Gaffney3, Raja Dey1,
Jamie A. Jarusiewicz3, Kaori Noridomi1,3, Michael A. Philips1, Xiao Lei1,2, Ju He1,
Jun Ye1, Tao Gao1, Nicos A. Petasis3,4,5 and Lin Chen1,2,3,4,6,*
1Molecular and ... |
3MU7 | Crystal structure of the xylanase and alpha-amylase inhibitor protein (XAIP-II) from scadoxus multiflorus at 1.2 A resolution | RESEARCH ARTICLE
Open Access
Modulation of inhibitory activity of xylanase -
a-amylase inhibitor protein (XAIP): binding
studies and crystal structure determination of
XAIP- II from Scadoxus multiflorus at 1.2 Å
resolution
Sanjit Kumar, Nagendra Singh, Biswajit Mishra, Divya Dube, Mau Sinha, S Baskar Singh, Sharmistha ... |
3MUD | Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle | Structure of the Tropomyosin Overlap Complex from Chicken
Smooth Muscle: Insight into the Diversity of N-Terminus
Recognition†,‡
Jeremiah Frye, Vadim A. Klenchin, and Ivan Rayment*
Department of Biochemistry, University of Wisconsin, Madison, U.S.A
Abstract
Tropomyosin is a stereotypical α-helical coiled-coil that poly... |
3MUF | Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP | Structures of Helicobacter pylori Shikimate Kinase
Reveal a Selective Inhibitor-Induced-Fit Mechanism
Wen-Chi Cheng1,2., Yen-Fu Chen3., Hung-Jung Wang1,2, Kai-Cheng Hsu3, Shuang-Chih Lin1, Tzu-Jung
Chen1, Jinn-Moon Yang3,4*, Wen-Ching Wang1,2*
1 Institute of Molecular and Cellular Biology and Department of Life Science... |
3MUG | Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody | Structure and function of broadly reactive antibody
PG16 reveal an H3 subdomain that mediates potent
neutralization of HIV-1
Robert Pejchala, Laura M. Walkerb, Robyn L. Stanfielda, Sanjay K. Phogatc, Wayne C. Koffc, Pascal Poignardb,d,
Dennis R. Burtonb,d,e,1, and Ian A. Wilsona,d,f,1
Departments of aMolecular Biology a... |
3MUH | Crystal structure of PG9 light chain | Structure and function of broadly reactive antibody
PG16 reveal an H3 subdomain that mediates potent
neutralization of HIV-1
Robert Pejchala, Laura M. Walkerb, Robyn L. Stanfielda, Sanjay K. Phogatc, Wayne C. Koffc, Pascal Poignardb,d,
Dennis R. Burtonb,d,e,1, and Ian A. Wilsona,d,f,1
Departments of aMolecular Biology a... |
3MUJ | Early B-cell factor 3 (EBF3) IPT/TIG and dimerization helices | Structural Determination of
Functional Domains in Early
B-cell Factor (EBF) Family of
Transcription Factors Reveals
Similarities to Rel DNA-binding
Proteins and a Novel
Dimerization Motif*□
S
Received for publication,June 2, 2010, and in revised form, June 16, 2010
Published, JBC Papers in Press,June 30, 2010, DOI 10.1... |
3MUM | Crystal Structure of the G20A mutant c-di-GMP riboswith bound to c-di-GMP | Structural and biochemical determinants of ligand binding by
the c-di-GMP riboswitch†,,‡
Kathryn D. Smith1, Sarah V. Lipchock1, Alison L. Livingston2, Carly A. Shanahan1, and
Scott A. Strobel1,2,*
1Department of Chemistry, Yale University, New Haven, Connecticut, USA
2Department of Molecular Biophysics and Biochemistry... |
3MUP | cIAP1-BIR3 domain in complex with the Smac-mimetic compound Smac037 | Recognition of Smac-mimetic compounds
by the BIR domain of cIAP1
Federica Cossu,1 Francesca Malvezzi,1 Giulia Canevari,1 Eloise Mastrangelo,1,2
Daniele Lecis,3 Domenico Delia,3 Pierfausto Seneci,4,5 Carlo Scolastico,4,5
Martino Bolognesi,1 and Mario Milani1,2*
1Dipartimento di Scienze Biomolecolari e Biotecnologie, Uni... |
3MUR | Crystal Structure of the C92U mutant c-di-GMP riboswith bound to c-di-GMP | Structural and biochemical determinants of ligand binding by
the c-di-GMP riboswitch†,,‡
Kathryn D. Smith1, Sarah V. Lipchock1, Alison L. Livingston2, Carly A. Shanahan1, and
Scott A. Strobel1,2,*
1Department of Chemistry, Yale University, New Haven, Connecticut, USA
2Department of Molecular Biophysics and Biochemistry... |
3MUS | 2A Resolution Structure of Rat Type B Cytochrome b5 | Accommodating a Non-Conservative Internal Mutation by Water-
Mediated Hydrogen-Bonding Between β-Sheet Strands: A
Comparison of Human and Rat Type B (Mitochondrial)
Cytochrome b5
Sudharsan Parthasarathy1, Adriana Altuve2, Simon Terzyan3, Xuejun Zhang3, Krzysztof
Kuczera1,2, Mario Rivera2, and David R. Benson1,2,*
1D... |
3MUT | Crystal Structure of the G20A/C92U mutant c-di-GMP riboswith bound to c-di-GMP | Structural and biochemical determinants of ligand binding by
the c-di-GMP riboswitch†,,‡
Kathryn D. Smith1, Sarah V. Lipchock1, Alison L. Livingston2, Carly A. Shanahan1, and
Scott A. Strobel1,2,*
1Department of Chemistry, Yale University, New Haven, Connecticut, USA
2Department of Molecular Biophysics and Biochemistry... |
3MUU | Crystal structure of the Sindbis virus E2-E1 heterodimer at low pH | Structural Changes of Envelope Proteins During Alphavirus
Fusion
Long Li, Joyce Jose, Ye Xiang, Richard J. Kuhn, and Michael G. Rossmann
Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN
47907-2054, USA
Abstract
Alphaviruses are enveloped RNA viruses that have a diameter of... |
3MUV | Crystal Structure of the G20A/C92U mutant c-di-GMP riboswith bound to c-di-AMP | Structural and biochemical determinants of ligand binding by
the c-di-GMP riboswitch†,,‡
Kathryn D. Smith1, Sarah V. Lipchock1, Alison L. Livingston2, Carly A. Shanahan1, and
Scott A. Strobel1,2,*
1Department of Chemistry, Yale University, New Haven, Connecticut, USA
2Department of Molecular Biophysics and Biochemistry... |
3MUW | Pseudo-atomic structure of the E2-E1 protein shell in Sindbis virus | Structural Changes of Envelope Proteins During Alphavirus
Fusion
Long Li, Joyce Jose, Ye Xiang, Richard J. Kuhn, and Michael G. Rossmann
Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN
47907-2054, USA
Abstract
Alphaviruses are enveloped RNA viruses that have a diameter of... |
3MV2 | Crystal Structure of a-COP in Complex with e-COP | Crystal structure of α-COP in complex with
ϵ-COP provides insight into the architecture
of the COPI vesicular coat
Kuo-Chiang Hsia and André Hoelz1
Laboratory of Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065
Communicated by Günter Blobel, The Rockefeller University, New York, NY, May 10... |
3MV3 | Crystal Structure of a-COP in Complex with e-COP | Crystal structure of α-COP in complex with
ϵ-COP provides insight into the architecture
of the COPI vesicular coat
Kuo-Chiang Hsia and André Hoelz1
Laboratory of Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065
Communicated by Günter Blobel, The Rockefeller University, New York, NY, May 10... |
3MV7 | Crystal Structure of the TK3 TCR in complex with HLA-B*3501/HPVG | Article
The Rockefeller University Press $30.00
J. Exp. Med. Vol. 207 No. 7 1555-1567
www.jem.org/cgi/doi/10.1084/jem.20100603
1555
MHC molecules play a critical role in protec-
tive immunity by presenting antigenic peptide
fragments for T cell recognition (Davis and
Bjorkman, 1988). MHC polymorphism enhances
immu... |
3MV8 | Crystal Structure of the TK3-Gln55His TCR in complex with HLA-B*3501/HPVG | Article
The Rockefeller University Press $30.00
J. Exp. Med. Vol. 207 No. 7 1555-1567
www.jem.org/cgi/doi/10.1084/jem.20100603
1555
MHC molecules play a critical role in protec-
tive immunity by presenting antigenic peptide
fragments for T cell recognition (Davis and
Bjorkman, 1988). MHC polymorphism enhances
immu... |
3MV9 | Crystal Structure of the TK3-Gln55Ala TCR in complex with HLA-B*3501/HPVG | Article
The Rockefeller University Press $30.00
J. Exp. Med. Vol. 207 No. 7 1555-1567
www.jem.org/cgi/doi/10.1084/jem.20100603
1555
MHC molecules play a critical role in protec-
tive immunity by presenting antigenic peptide
fragments for T cell recognition (Davis and
Bjorkman, 1988). MHC polymorphism enhances
immu... |
3MVA | Crystal structure of human MTERF1 bound to the termination sequence | Helix unwinding and base flipping enable human MTERF1 to
terminate mitochondrial transcription
Elena Yakubovskaya*, Edison Mejia*, James Byrnes, Elena Hambardjieva, and Miguel
Garcia-Diaz1
Department of Pharmacological Sciences. Stony Brook University. BST 7-169. Stony Brook, New
York, 11794-8651
Summary
Defects in mit... |
3MVB | Crystal structure of a triple RFY mutant of human MTERF1 bound to the termination sequence | Helix unwinding and base flipping enable human MTERF1 to
terminate mitochondrial transcription
Elena Yakubovskaya*, Edison Mejia*, James Byrnes, Elena Hambardjieva, and Miguel
Garcia-Diaz1
Department of Pharmacological Sciences. Stony Brook University. BST 7-169. Stony Brook, New
York, 11794-8651
Summary
Defects in mit... |
3MVC | High resolution crystal structure of the heme domain of GLB-6 from C. elegans | Structure and Properties of a Bis-Histidyl Ligated Globin from
Caenorhabditis elegans†
Jungjoo Yoon‡, Mark A. Herzik Jr.‡,§, Michael B. Winter‡,∥, Rosalie Tran‡,∥, Charles Olea
Jr.‡,§, and Michael A. Marletta*,‡,§,∥,⊥
‡California Institute for Quantitative Biosciences, University of California, Berkeley, California
947... |
3MVD | Crystal structure of the chromatin factor RCC1 in complex with the nucleosome core particle | Structure of RCC1 chromatin factor bound to the nucleosome
core particle
Ravindra D. Makde1, Joseph R. England2, Hemant P. Yennawar, and Song Tan
Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The
Pennsylvania State University, University Park, PA 16802, USA
Abstract
The small ... |
3MVI | Crystal structure of holo mADA at 1.6 A resolution | The Role of Zn2+ on the Structure and Stability of Murine
Adenosine Deaminase
Weiling Niu†,#, Qin Shu*,#, Zhiwei Chen†, Scott Mathews*, Enrico Di Cera†, and Carl
Frieden*
*Department of Biochemistry and Molecular Biophysics, Washington University School of
Medicine, St. Louis, MO 63110
†Edward A. Doisy Department of Bi... |
3MVR | Crystal Structure of cytochrome P450 2B4-H226Y in a closed conformation | Plasticity of Cytochrome P450 2B4 as Investigated by
Hydrogen-Deuterium Exchange Mass Spectrometry
and X-ray Crystallography*□
S
Received for publication,August 31, 2010, and in revised form, September 27, 2010 Published, JBC Papers in Press,September 28, 2010, DOI 10.1074/jbc.M110.180646
P. Ross Wilderman‡1,2, Manish ... |
3MVS | Structure of the N-terminus of Cadherin 23 | Structure of the N terminus of cadherin 23 reveals
a new adhesion mechanism for a subset of
cadherin superfamily members
Heather M. Elledgea,b,1, Piotr Kazmierczaka,b,1, Peter Clarka,1, Jeremiah S. Josepha, Anand Kolatkara, Peter Kuhna,2,
and Ulrich Müllera,b,2
aDepartment of Cell Biology and bDorris Neuroscience Cente... |
3MVT | Crystal structure of apo mADA at 2.2A resolution | The Role of Zn2+ on the Structure and Stability of Murine
Adenosine Deaminase
Weiling Niu†,#, Qin Shu*,#, Zhiwei Chen†, Scott Mathews*, Enrico Di Cera†, and Carl
Frieden*
*Department of Biochemistry and Molecular Biophysics, Washington University School of
Medicine, St. Louis, MO 63110
†Edward A. Doisy Department of Bi... |
3MVV | Crystal structure of Staphylococcal nuclease variant Delta+PHS F34A at cryogenic temperature | Cavities determine the pressure unfolding of proteins
Julien Rochea,1, Jose A. Carob,1, Douglas R. Norbertoa,c, Philippe Barthea, Christian Roumestanda, Jamie L. Schlessmand,
Angel E. Garciae, Bertrand García-Moreno E.b, and Catherine A. Royera,2
aCentre de Biochimie Structurale, Institut National pour la Santé et la R... |
3MW2 | Crystal structure of beta-neurexin 1 with the splice insert 4 | Splice form-dependence of β-neurexin/neuroligin binding
interactions
Jesko Koehnke1,†, Phinikoula S. Katsamba1,2,†, Goran Ahlsen1, Fabiana Bahna1,2, Jeremie
Vendome1,2, Barry Honig1,2,*, Lawrence Shapiro1,3,*, and Xiangshu Jin1,2,†
1 Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY... |
3MW3 | Crystal structure of beta-neurexin 2 with the splice insert 4 | Splice form-dependence of β-neurexin/neuroligin binding
interactions
Jesko Koehnke1,†, Phinikoula S. Katsamba1,2,†, Goran Ahlsen1, Fabiana Bahna1,2, Jeremie
Vendome1,2, Barry Honig1,2,*, Lawrence Shapiro1,3,*, and Xiangshu Jin1,2,†
1 Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY... |
3MW4 | Crystal structure of beta-neurexin 3 without the splice insert 4 | Splice form-dependence of β-neurexin/neuroligin binding
interactions
Jesko Koehnke1,†, Phinikoula S. Katsamba1,2,†, Goran Ahlsen1, Fabiana Bahna1,2, Jeremie
Vendome1,2, Barry Honig1,2,*, Lawrence Shapiro1,3,*, and Xiangshu Jin1,2,†
1 Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY... |
3MW6 | Crystal structure of NMB1681 from Neisseria meningitidis MC58, a FinO-like RNA chaperone | RNA Biology 7:6, 812-819; November/December 2010; © 2010 Landes Bioscience
Research paper
812
RNA Biology
Volume 7 Issue 6
*Correspondence to: J.N. Mark Glover; Email: mark.glover@ualberta.ca
Submitted: 09/03/10; Revised: 09/16/10; Accepted: 09/18/10
Previously published online: www.landesbioscience.com/journals/rna... |
3MWD | Truncated Human ATP-Citrate Lyase with Citrate Bound | Identification of the Citrate-binding Site of Human
ATP-Citrate Lyase Using X-ray Crystallography*□
S
Received for publication,October 22, 2009, and in revised form, May 10, 2010 Published, JBC Papers in Press,June 17, 2010, DOI 10.1074/jbc.M109.078667
Tianjun Sun, Koto Hayakawa, Katherine S. Bateman1, and Marie E. Fra... |
3MWE | Truncated Human ATP-Citrate Lyase with Tartrate Bound | Identification of the Citrate-binding Site of Human
ATP-Citrate Lyase Using X-ray Crystallography*□
S
Received for publication,October 22, 2009, and in revised form, May 10, 2010 Published, JBC Papers in Press,June 17, 2010, DOI 10.1074/jbc.M109.078667
Tianjun Sun, Koto Hayakawa, Katherine S. Bateman1, and Marie E. Fra... |
3MWH | The 1.4 Ang crystal structure of the ArsD arsenic metallochaperone provides insights into its interactions with the ArsA ATPase | The 1.4 Å crystal structure of the ArsD arsenic metallochaperone
provides insights into its interaction with the ArsA ATPase†
Jun Ye‡,#, A. Abdul Ajees§,#, Jianbo Yang‡, and Barry P. Rosen*,§
‡Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine,
Detroit, MI 48201
§Department of ... |
3MWM | Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur | Graded expression of zinc-responsive genes through
two regulatory zinc-binding sites in Zur
Jung-Ho Shina,1, Hoi Jong Jungb,1, Young Jun Anb, Yoo-Bok Choa, Sun-Shin Chab,c,2, and Jung-Hye Roea,2
aLaboratory of Molecular Microbiology, School of Biological Sciences, and Institute of Microbiology, Seoul National Universit... |
3MWO | Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination | short communications
950
doi:10.1107/S0907444910023723
Acta Cryst. (2010). D66, 950–952
Acta Crystallographica Section D
Biological
Crystallography
ISSN 0907-4449
Emerging from pseudo-symmetry: the
redetermination of human carbonic anhydrase II in
monoclinic P21 with a doubled a axis
Arthur H. Robbins, John F.
Domsic, ... |
3MWP | Nucleoprotein structure of lassa fever virus | Cap binding and immune evasion revealed by Lassa
nucleoprotein structure
Xiaoxuan Qi1, Shuiyun Lan2, Wenjian Wang3, Lisa McLay Schelde2, Haohao Dong1, Gregor
D. Wallat1, Hinh Ly2,*, Yuying Liang2,*, and Changjiang Dong1,*
1Biomedical Sciences Research Complex, School of Chemistry, University of St. Andrews, North
Ha... |
3MWS | Crystal Structure of Group N HIV-1 Protease | Autocatalytic maturation, physical/
chemical properties, and crystal structure
of Group N HIV-1 protease: Relevance to
drug resistance
Jane M. Sayer,1 Johnson Agniswamy,2 Irene T. Weber,2 and John M. Louis1*
1Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Inst... |
3MWT | Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+ | Cap binding and immune evasion revealed by Lassa
nucleoprotein structure
Xiaoxuan Qi1, Shuiyun Lan2, Wenjian Wang3, Lisa McLay Schelde2, Haohao Dong1, Gregor
D. Wallat1, Hinh Ly2,*, Yuying Liang2,*, and Changjiang Dong1,*
1Biomedical Sciences Research Complex, School of Chemistry, University of St. Andrews, North
Ha... |
3MWU | Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95 | Published on Web Date: July 07, 2010
r 2010 American Chemical Society
331
DOI: 10.1021/ml100096t |ACS Med. Chem. Lett. 2010, 1, 331–335
pubs.acs.org/acsmedchemlett
Discovery of Potent and Selective Inhibitors of CDPK1
from C. parvum and T. gondii
Ryan C. Murphy,†,O Kayode K. Ojo,‡,O Eric T. Larson,§,
)
Alejandro Castel... |
3MWY | Crystal structure of the chromodomain-ATPase portion of the yeast Chd1 chromatin remodeler | The Chromodomains of the Chd1 Chromatin Remodeler
Regulate DNA Access to the ATPase Motor
Glenn Hauk*, Jeffrey N. McKnight*, Ilana M. Nodelman, and Gregory D. Bowman1
T.C. Jenkins Department of Biophysics, Johns Hopkins University Baltimore, Maryland
21218-2685, USA
Summary
Chromatin remodelers are ATP-driven machines ... |
3MWZ | Crystal structure of the selenomethionine derivative of the L 22,47,100 M mutant of sialostatin L2 | The crystal structures of two salivary cystatins from the tick
Ixodes scapularis and the effect of these inhibitors on the
establishment of Borrelia burgdorferi infection in a murine
model
Michalis Kotsyfakis1,2, Helena Horka1,3, Jiri Salat3,4, and John F. Andersen2
1 Laboratory of Genomics and Proteomics of Disease Ve... |
3MX0 | Crystal Structure of EphA2 ectodomain in complex with ephrin-A5 | Architecture of Eph receptor clusters
Juha P. Himanena,1, Laila Yermekbayevab,1, Peter W. Janesc,1, John R. Walkerb,1, Kai Xua, Lakmali Atapattuc,
Kanagalaghatta R. Rajashankard, Anneloes Mensingac, Martin Lackmannc,2,
Dimitar B. Nikolova,2, and Sirano Dhe-Paganonb,e,2
aStructural Biology Program, Memorial Sloan-Ketter... |
3MX1 | The structure of GIY-YIG endonuclease R.Eco29kI | Folding, DNA recognition and function of GIY-YIG
endonucleases: crystal structures of R.Eco29kI
Amanda Nga-Sze Mak1, Abigail R. Lambert1,2, and Barry L. Stoddard1,3
1 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N.
A3-025 Seattle, WA 98109
Abstract
The GIY-YIG endonuclease fami... |
3MX2 | Lassa fever virus Nucleoprotein complexed with dTTP | Cap binding and immune evasion revealed by Lassa
nucleoprotein structure
Xiaoxuan Qi1, Shuiyun Lan2, Wenjian Wang3, Lisa McLay Schelde2, Haohao Dong1, Gregor
D. Wallat1, Hinh Ly2,*, Yuying Liang2,*, and Changjiang Dong1,*
1Biomedical Sciences Research Complex, School of Chemistry, University of St. Andrews, North
Ha... |
3MX4 | DNA binding and cleavage by the GIY-YIG endonuclease R.Eco29KI inactive variant E142Q | Folding, DNA recognition and function of GIY-YIG
endonucleases: crystal structures of R.Eco29kI
Amanda Nga-Sze Mak1, Abigail R. Lambert1,2, and Barry L. Stoddard1,3
1 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N.
A3-025 Seattle, WA 98109
Abstract
The GIY-YIG endonuclease fami... |
3MX5 | Lassa fever virus nucleoprotein complexed with UTP | Cap binding and immune evasion revealed by Lassa
nucleoprotein structure
Xiaoxuan Qi1, Shuiyun Lan2, Wenjian Wang3, Lisa McLay Schelde2, Haohao Dong1, Gregor
D. Wallat1, Hinh Ly2,*, Yuying Liang2,*, and Changjiang Dong1,*
1Biomedical Sciences Research Complex, School of Chemistry, University of St. Andrews, North
Ha... |
3MX6 | Crystal structure of methionine aminopeptidase from Rickettsia prowazekii bound to methionine | Rickettsia prowazekii Methionine Aminopeptidase as a
Promising Target for the Development of Antibacterial Agents
Travis R. Helgren†, Congling Chen†, Phumvadee Wangtrakuldee†, Thomas E. Edwards‡,
Bart L. Staker₴,Δ, Jan Abendroth‡, Banumathi SankaranⱵ, Nicole A. Housleyǁ, Peter J. Myler
$,Δ,₸, Jonathon P. Audiaǁ, Jame... |
3MX9 | Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus | Molecular basis of engineered meganuclease
targeting of the endogenous human RAG1 locus
Ine´ s G. Mun˜ oz1, Jesu´ s Prieto1, Sunita Subramanian1, Javier Coloma1, Pilar Redondo1,
Maider Villate2, Nekane Merino2, Marco Marenchino3, Marco D’Abramo4,
Francesco L. Gervasio4, Sylvestre Grizot5, Fayza Daboussi5, Julianne Smit... |
3MXA | Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus | Molecular basis of engineered meganuclease
targeting of the endogenous human RAG1 locus
Ine´ s G. Mun˜ oz1, Jesu´ s Prieto1, Sunita Subramanian1, Javier Coloma1, Pilar Redondo1,
Maider Villate2, Nekane Merino2, Marco Marenchino3, Marco D’Abramo4,
Francesco L. Gervasio4, Sylvestre Grizot5, Fayza Daboussi5, Julianne Smit... |
3MXB | Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus | Molecular basis of engineered meganuclease
targeting of the endogenous human RAG1 locus
Ine´ s G. Mun˜ oz1, Jesu´ s Prieto1, Sunita Subramanian1, Javier Coloma1, Pilar Redondo1,
Maider Villate2, Nekane Merino2, Marco Marenchino3, Marco D’Abramo4,
Francesco L. Gervasio4, Sylvestre Grizot5, Fayza Daboussi5, Julianne Smit... |
3MXD | Crystal structure of HIV-1 protease inhibitor KC53 in complex with wild-type protease | Structure-Based Design, Synthesis and Structure-Activity
Relationship Studies of HIV-1 Protease Inhibitors Incorporating
Phenyloxazolidinones
Akbar Ali†,‡,§, G. S. Kiran Kumar Reddy†,‡,§, Madhavi N. L. Nalam‡, Saima Ghafoor
Anjum†,‡, Hong Cao†,‡, Celia A. Schiffer‡,*, and Tariq M. Rana†,‡,*,¶
Celia A. Schiffer: Celia.S... |
3MXE | Crystal structure of HIV-1 protease inhibitor, KC32 complexed with wild-type protease | Structure-Based Design, Synthesis and Structure-Activity
Relationship Studies of HIV-1 Protease Inhibitors Incorporating
Phenyloxazolidinones
Akbar Ali†,‡,§, G. S. Kiran Kumar Reddy†,‡,§, Madhavi N. L. Nalam‡, Saima Ghafoor
Anjum†,‡, Hong Cao†,‡, Celia A. Schiffer‡,*, and Tariq M. Rana†,‡,*,¶
Celia A. Schiffer: Celia.S... |
3MXF | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JQ1 | Selective inhibition of BET bromodomains
Panagis Filippakopoulos1,*, Jun Qi2,*, Sarah Picaud1,*, Yao Shen3, William B. Smith2, Oleg
Fedorov1, Elizabeth M. Morse2, Tracey Keates1, Tyler T. Hickman4, Ildiko Felletar1, Martin
Philpott1, Shonagh Munro5, Michael R. McKeown2,9, Yuchuan Wang6, Amanda L. Christie7,
Nathan W... |
3MXG | Structure of Shiga Toxin type 2 (Stx2) B Pentamer Mutant Q40L | Molecular Basis of Differential B-Pentamer Stability of
Shiga Toxins 1 and 2
Deborah G. Conrady., Michael J. Flagler.¤a, David R. Friedmann.¤b, Bradley D. Vander Wielen, Rhett A.
Kovall*, Alison A. Weiss*, Andrew B. Herr*
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College ... |
3MXH | Native structure of a c-di-GMP riboswitch from V. cholerae | Structural and biochemical determinants of ligand binding by
the c-di-GMP riboswitch†,,‡
Kathryn D. Smith1, Sarah V. Lipchock1, Alison L. Livingston2, Carly A. Shanahan1, and
Scott A. Strobel1,2,*
1Department of Chemistry, Yale University, New Haven, Connecticut, USA
2Department of Molecular Biophysics and Biochemistry... |
3MXL | Crystal structure of nitrososynthase from Micromonospora carbonacea var. africana | Structure and mechanism of ORF36, an Aminosugar Oxidizing
Enzyme in Everninomicin Biosynthesis†
Jessica L. Vey1, Ahmad Al-Mestarihi2, Yunfeng Hu2,&, Michael A. Funk1,@, Brian O.
Bachmann2,3,*, and T. M. Iverson1,3,*
1Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
2Department ... |
3MXN | Crystal structure of the RMI core complex | Structure and cellular roles of the RMI core complex from the
Bloom syndrome dissolvasome
Kelly A. Hoadley1, Dongyi Xu2, Yutong Xue2, Kenneth A. Satyshur1, Weidong Wang2,‡, and
James L. Keck1,‡
1 Department of Biomolecular Chemistry, 550 Medical Science Center, 1300 University Avenue,
University of Wisconsin School of ... |
3MXO | Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5) | Article
Structures of PGAM5 Provide Insight into Active Site
Plasticity and Multimeric Assembly
Graphical Abstract
Highlights
d PGAM5 catalytic domain shares phosphoglycerate mutase
fold and forms stable dimer
d WDPNWD motif allosterically activates the fully active
dodecameric form
d Crystal structures reveal conforma... |
3MXP | Crystal structure of Staphylococcal nuclease variant Delta+PHS T62A at cryogenic temperature | Cavities determine the pressure unfolding of proteins
Julien Rochea,1, Jose A. Carob,1, Douglas R. Norbertoa,c, Philippe Barthea, Christian Roumestanda, Jamie L. Schlessmand,
Angel E. Garciae, Bertrand García-Moreno E.b, and Catherine A. Royera,2
aCentre de Biochimie Structurale, Institut National pour la Santé et la R... |
3MXR | SHV-1 beta-lactamase complex with compound 1 | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 2011, p. 174–183
Vol. 55, No. 1
0066-4804/11/$12.00
doi:10.1128/AAC.00930-10
Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Novel Insights into the Mode of Inhibition of Class A SHV-1 -Lactamases
Revealed by Boronic Acid Transition State Inhibitors... |
3MXS | SHV-1 beta-lactamase complex with compound 2 | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 2011, p. 174–183
Vol. 55, No. 1
0066-4804/11/$12.00
doi:10.1128/AAC.00930-10
Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Novel Insights into the Mode of Inhibition of Class A SHV-1 -Lactamases
Revealed by Boronic Acid Transition State Inhibitors... |
3MXV | Crystal structure of fab fragment of anti-Shh 5E1 chimera | Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the
Pseudo-active Site
Received for publication,February 8, 2010, and in revised form, May 14, 2010 Published, JBC Papers in Press,May 26, 2010, DOI 10.1074/jbc.M110.112284
Henry R. Maun‡, Xiaohui Wen§, Andreas Lingel‡, Frederic J. de Sauvage§, Robert A. Lazarus‡, Suzie... |
3MXW | Crystal structure Sonic hedgehog bound to the 5E1 fab fragment | Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the
Pseudo-active Site
Received for publication,February 8, 2010, and in revised form, May 14, 2010 Published, JBC Papers in Press,May 26, 2010, DOI 10.1074/jbc.M110.112284
Henry R. Maun‡, Xiaohui Wen§, Andreas Lingel‡, Frederic J. de Sauvage§, Robert A. Lazarus‡, Suzie... |
3MY0 | Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 | BRIEF COMMUNICATION
A small molecule targeting ALK1 prevents Notch cooperativity
and inhibits functional angiogenesis
Georgina Kerr • Helen Sheldon • Apirat Chaikuad •
Ivan Alfano • Frank von Delft • Alex N. Bullock •
Adrian L. Harris
Received: 20 August 2014 / Accepted: 22 December 2014 / Published online: 4 January 2... |
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