protein_name stringlengths 4 4 | structure_title stringlengths 3 322 | main_text stringlengths 0 302k |
|---|---|---|
3NH4 | Crystal structure of murine aminoacylase 3 | Structures of aminoacylase 3 in complex
with acetylated substrates
Jennifer M. Hsieha,b,1, Kirill Tsirulnikovc,1, Michael R. Sawayad, Nathaniel Magilnickc, Natalia Abuladzec, Ira Kurtzc,
Jeff Abramsonb,2, and Alexander Pushkinc,2
aDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095... |
3NH5 | Crystal structure of E177A-mutant murine aminoacylase 3 | Structures of aminoacylase 3 in complex
with acetylated substrates
Jennifer M. Hsieha,b,1, Kirill Tsirulnikovc,1, Michael R. Sawayad, Nathaniel Magilnickc, Natalia Abuladzec, Ira Kurtzc,
Jeff Abramsonb,2, and Alexander Pushkinc,2
aDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095... |
3NH7 | Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA | A Selection Fit Mechanism in BMP Receptor IA as a
Possible Source for BMP Ligand-Receptor Promiscuity
Stefan Harth1, Alexander Kotzsch2, Junli Hu1, Walter Sebald1, Thomas D. Mueller2*
1 Lehrstuhl fu¨r Physiologische Chemie II, Theodor-Boveri-Institut fu¨r Biowissenschaften der Universita¨t Wu¨rzburg, Wu¨rzburg, Germany... |
3NH8 | Crystal structure of murine aminoacylase 3 in complex with N-acetyl-S-1,2-dichlorovinyl-L-cysteine | Structures of aminoacylase 3 in complex
with acetylated substrates
Jennifer M. Hsieha,b,1, Kirill Tsirulnikovc,1, Michael R. Sawayad, Nathaniel Magilnickc, Natalia Abuladzec, Ira Kurtzc,
Jeff Abramsonb,2, and Alexander Pushkinc,2
aDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095... |
3NHC | GYMLGS segment 127-132 from human prion with M129 | Crystallographic Studies of
Prion Protein (PrP) Segments
Suggest How Structural
Changes Encoded by
Polymorphism at Residue 129
Modulate Susceptibility to
Human Prion Disease*
Received for publication,June 24, 2010, and in revised form, July 19, 2010
Published, JBC Papers in Press,August 4, 2010, DOI 10.1074/jbc.C110.15... |
3NHD | GYVLGS segment 127-132 from human prion with V129 | Crystallographic Studies of
Prion Protein (PrP) Segments
Suggest How Structural
Changes Encoded by
Polymorphism at Residue 129
Modulate Susceptibility to
Human Prion Disease*
Received for publication,June 24, 2010, and in revised form, July 19, 2010
Published, JBC Papers in Press,August 4, 2010, DOI 10.1074/jbc.C110.15... |
3NHG | RB69 DNA Polymerase (S565G/Y567A) Ternary Complex with dTTP Opposite dG | Variation in Mutation Rates Caused by RB69pol Fidelity Mutants
Can Be Rationalized on the Basis of Their Kinetic Behavior and
Crystal Structures
Shuangluo Xia1,¥, Mina Wang1,¥, Harold R. Lee1,*, Arjun Sinha1,Δ, Gregor Blaha2,
Thomas Christian1, Jimin Wang2,Ω,†, and William Konigsberg1,Ω,†
1 Department of Molecular Biop... |
3NHH | Crystal structure of Staphylococcal nuclease variant V23E-L36K at cryogenic temperature | Structural and thermodynamic consequences of burial
of an artificial ion pair in the hydrophobic interior
of a protein
Aaron C. Robinsona, Carlos A. Castañedaa, Jamie L. Schlessmana,b, and Bertrand García-Moreno E.a,1
aDepartment of Biophysics, Johns Hopkins University, Baltimore, MD 21218; and bChemistry Department, U... |
3NHI | Crystal structure of the AnSt-D7L1-leukotriene C4 complex | The Function and Three-Dimensional Structure of a
Thromboxane A2/Cysteinyl Leukotriene-Binding Protein
from the Saliva of a Mosquito Vector of the Malaria
Parasite
Patricia H. Alvarenga1,2, Ivo M. B. Francischetti1, Eric Calvo1, Anderson Sa´-Nunes1,3, Jose´ M. C. Ribeiro1,
John F. Andersen1*
1 Laboratory of Malaria and... |
3NHN | Crystal structure of the SRC-family kinase HCK SH3-SH2-linker regulatory region | Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker
Regulatory Region Supports an SH3-dominant Activation
Mechanism*
Received for publication,May 17, 2010, and in revised form, July 8, 2010 Published, JBC Papers in Press,September 1, 2010, DOI 10.1074/jbc.M110.145102
John J. Alvarado‡, Laurie Betts‡, Jamie A.... |
3NHQ | The dark Pfr structure of the photosensory core module of P. aeruginosa Bacteriophytochrome | Temperature-Scan Cryocrystallography Reveals Reaction
Intermediates in Bacteriophytochrome
Xiaojing Yang*,≠, Zhong Ren#, Jane Kuk*, and Keith Moffat*,#,≠
*Department of Biochemistry and Molecular Biology, The University of Chicago 929 East 57th
Street Chicago, IL 60637, U.S.A.
≠Institute for Biophysical Dynamics, The U... |
3NHT | Crystal structure of the AnSt-D7L1-U46619 complex | The Function and Three-Dimensional Structure of a
Thromboxane A2/Cysteinyl Leukotriene-Binding Protein
from the Saliva of a Mosquito Vector of the Malaria
Parasite
Patricia H. Alvarenga1,2, Ivo M. B. Francischetti1, Eric Calvo1, Anderson Sa´-Nunes1,3, Jose´ M. C. Ribeiro1,
John F. Andersen1*
1 Laboratory of Malaria and... |
3NHZ | Structure of N-terminal Domain of MtrA | Regulation of Response Regulator Autophosphorylation
through Interdomain Contacts*□
S
Received for publication,June 25, 2010, and in revised form, July 29, 2010 Published, JBC Papers in Press,August 11, 2010, DOI 10.1074/jbc.M110.157164
Christopher M. Barbieri‡§¶, Timothy R. Mack‡§1, Victoria L. Robinson‡§¶2, Matthe... |
3NI0 | Crystal Structure of Mouse BST-2/Tetherin Ectodomain | Structural and Biophysical Analysis of BST-2/Tetherin
Ectodomains Reveals an Evolutionary Conserved Design to
Inhibit Virus Release
□
S
Received for publication,September 30, 2010, and in revised form, November 2, 2010 Published, JBC Papers in Press,November 17, 2010, DOI 10.1074/jbc.M110.190538
Melissa Swiecki‡1, Suza... |
3NI3 | 54-Membered ring macrocyclic beta-sheet peptide | X-ray Crystallographic Structure of an Artificial -Sheet Dimer
Omid Khakshoor,† Aaron J. Lin,† Tyler P. Korman,† Michael R. Sawaya,‡
Shiou-Chuan Tsai,† David Eisenberg,‡ and James S. Nowick*,†
Department of Chemistry, UniVersity of California, IrVine, California 92697-2025, and Howard
Hughes Medical Institute, UCLA-DOE... |
3NI6 | Crystal structure of the FK506 binding domain of Plasmodium vivax FKBP35 | Structural Insights into Substrate Binding by PvFKBP35, a
Peptidylprolyl cis-trans Isomerase from the Human Malarial Parasite
Plasmodium vivax
Reema Alag, Asha Manikkoth Balakrishna, Sreekanth Rajan, Insaf A. Qureshi,* Joon Shin, Julien Lescar, Gerhard Grüber, Ho Sup Yoon
School of Biological Sciences, Nanyang Technolo... |
3NI9 | GES-2 carbapenemase apo form | Kinetic and Structural Requirements for Carbapenemase Activity in
GES-Type β‑Lactamases
Nichole K. Stewart,† Clyde A. Smith,‡ Hilary Frase,† D. J. Black,§ and Sergei B. Vakulenko*,†
†Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
‡Stanford Synchrotron Radiat... |
3NIB | Teg14 Apo | research papers
1278
doi:10.1107/S0907444910036681
Acta Cryst. (2010). D66, 1278–1286
Acta Crystallographica Section D
Biological
Crystallography
ISSN 0907-4449
The 2.7 A˚ resolution structure of the glycopeptide
sulfotransferase Teg14
Matthew J. Bick,a Jacob J.
Banik,b Seth A. Darsta and
Sean F. Bradyb*
aLaboratory of... |
3NIC | DNA binding and cleavage by the GIY-YIG endonuclease R.Eco29kI inactive variant Y49F | Folding, DNA recognition and function of GIY-YIG
endonucleases: crystal structures of R.Eco29kI
Amanda Nga-Sze Mak1, Abigail R. Lambert1,2, and Barry L. Stoddard1,3
1 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N.
A3-025 Seattle, WA 98109
Abstract
The GIY-YIG endonuclease fami... |
3NIR | Crystal structure of small protein crambin at 0.48 A resolution | structural communications
424
doi:10.1107/S1744309110052607
Acta Cryst. (2011). F67, 424–428
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Crystal structure of small protein crambin at 0.48 A˚
resolution
Andrea Schmidt,a* Martha
Teeter,b Edgar Weckertc and
Victor ... |
3NJ0 | X-ray crystal structure of the PYL2-pyrabactin A complex | Structural basis for selective activation of ABA receptors
Francis C. Peterson1,5, E. Sethe Burgie2,5, Sang-Youl Park3, Davin R. Jensen1, Joshua J.
Weiner1, Craig A. Bingman2, Chia-An Chang3, Sean R. Cutler3,4, George N. Phillips Jr.2,
and Brian F. Volkman1
1Dept. of Biochemistry and Center for Eukaryotic Structural ... |
3NJ1 | X-ray crystal structure of the PYL2(V114I)-pyrabactin A complex | Structural basis for selective activation of ABA receptors
Francis C. Peterson1,5, E. Sethe Burgie2,5, Sang-Youl Park3, Davin R. Jensen1, Joshua J.
Weiner1, Craig A. Bingman2, Chia-An Chang3, Sean R. Cutler3,4, George N. Phillips Jr.2,
and Brian F. Volkman1
1Dept. of Biochemistry and Center for Eukaryotic Structural ... |
3NJ2 | Crystal structure of cce_0566 from the cyanobacterium Cyanothece 51142, a protein associated with nitrogen fixation from the DUF269 family | Crystal structure of cce_0566 from Cyanothece 51142, a protein
associated with nitrogen fixation in the DUF269 family
Garry W. Buchkoa,* and Howard Robinsonb
aBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
bBiology Department, Brookhaven National Laboratory, Upton, NY 11973... |
3NJ6 | 0.95 A resolution X-ray structure of (GGCAGCAGCC)2 | Atomic resolution structure of CAG RNA repeats:
structural insights and implications for the
trinucleotide repeat expansion diseases
Agnieszka Kiliszek, Ryszard Kierzek, Wlodzimierz J. Krzyzosiak and
Wojciech Rypniewski*
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, P... |
3NJ7 | 1.9 A resolution X-ray structure of (GGCAGCAGCC)2 | Atomic resolution structure of CAG RNA repeats:
structural insights and implications for the
trinucleotide repeat expansion diseases
Agnieszka Kiliszek, Ryszard Kierzek, Wlodzimierz J. Krzyzosiak and
Wojciech Rypniewski*
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, P... |
3NJ8 | Crystal structure of T. gondii enoyl acyl carrier protein reductase with bound triclosan like inhibitor | Identification and Development of Novel Inhibitors of
Toxoplasma gondii Enoyl Reductase
Suresh K. Tipparaju‡,+, Stephen P. Muench†,+, Ernest J. Mui#,+, Sergey N. Ruzheinikov^,+,
Jeffrey Z. Lu§, Samuel L. Hutson#, Michael J. Kirisits#, Sean T. Prigge§, Craig W. Roberts∫,
Fiona L. Henriquez∫, Alan P. Kozikowski‡, David W... |
3NJB | Crystal structure of enoyl-coa hydratase from Mycobacterium smegmatis, iodide soak | SAD phasing using iodide ions in a high-throughput structural
genomics environment
Jan Abendroth • Anna S. Gardberg • John I. Robinson •
Jeff S. Christensen • Bart L. Staker • Peter J. Myler •
Lance J. Stewart • Thomas E. Edwards
Received: 19 November 2010 / Accepted: 14 February 2011 / Published online: 27 February 20... |
3NJD | Crystal structure of enoyl-coa hydratase from mycobacterium smegmatis | Increasing the Structural Coverage of Tuberculosis Drug Targets
Loren Baugha,b, Isabelle Phana,b, Darren W. Begleya,c, Matthew C. Cliftona,c, Brianna
Armoura,c, David M. Dranowa,c, Brandy M. Taylora,c, Marvin M. Muruthia,c, Jan
Abendrotha,c, James W. Fairmanc, David Fox IIIc, Shellie H. Dieterichc, Bart L. Stakera,b,... |
3NJE | Structure of the Minor Pseudopilin XcpW from the Pseudomonas aeruginosa Type II Secretion System | research papers
124
doi:10.1107/S0907444910051954
Acta Cryst. (2011). D67, 124–130
Acta Crystallographica Section D
Biological
Crystallography
ISSN 0907-4449
Structure of the minor pseudopilin XcpW from the
Pseudomonas aeruginosa type II secretion system
Laura P. Franz,a Badreddine
Douzi,b,c Eric Durand,d David H.
Dyer... |
3NJF | Y26F mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3NJG | K98A mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis. | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3NJH | D37A mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis. | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3NJI | S114A mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis. | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3NJJ | P115A mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3NJK | D116A mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis, at pH5.5 | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3NJL | D116A mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis, at pH7.5 | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3NJM | P117A mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis. | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3NJN | Q118A mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis | Characterization of Member of DUF1888 Protein Family,
Self-cleaving and Self-assembling Endopeptidase*□
S
Received for publication,March 2, 2012, and in revised form, March 27, 2012 Published, JBC Papers in Press,April 5, 2012, DOI 10.1074/jbc.M112.358069
Jerzy Osipiuk‡, Rory Mulligan‡, Monireh Bargassa‡, John E. Hamil... |
3NJO | X-ray crystal structure of the Pyr1-pyrabactin A complex | Structural basis for selective activation of ABA receptors
Francis C. Peterson1,5, E. Sethe Burgie2,5, Sang-Youl Park3, Davin R. Jensen1, Joshua J.
Weiner1, Craig A. Bingman2, Chia-An Chang3, Sean R. Cutler3,4, George N. Phillips Jr.2,
and Brian F. Volkman1
1Dept. of Biochemistry and Center for Eukaryotic Structural ... |
3NJP | The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling | MOLECULAR AND CELLULAR BIOLOGY, Nov. 2010, p. 5432–5443
Vol. 30, No. 22
0270-7306/10/$12.00
doi:10.1128/MCB.00742-10
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Structural Evidence for Loose Linkage between Ligand Binding and
Kinase Activation in the Epidermal Growth Factor Receptor
Chafe... |
3NJQ | Crystal structure of Kaposi's sarcoma-associated herpesvirus protease in complex with dimer disruptor | Enzyme Inhibition by Allosteric Capture of an Inactive
Conformation
Gregory M. Lee1, Tina Shahian2, Aida Baharuddin1, Jonathan E. Gable3, and Charles S.
Craik1,*
1Department of Pharmaceutical Chemistry, University of California, San Francisco, CA
94158-2280, USA
2Graduate Group in Biochemistry and Molecular Biology, Un... |
3NJR | Crystal structure of C-terminal domain of precorrin-6Y C5,15-methyltransferase from Rhodobacter capsulatus | An enzyme-trap approach allows isolation of intermediates in
cobalamin biosynthesis
Evelyne Deery1, Susanne Schroeder1,*, Andrew D. Lawrence1,*, Samantha L. Taylor1,
Arefeh Seyedarabi2, Jitka Waterman3, Keith S. Wilson3, David Brown1, Michael A. Geeves1,
Mark J. Howard1, Richard W. Pickersgill2, and Martin J. Warren1
1... |
3NJY | Crystal structure of JMJD2A complexed with 5-carboxy-8-hydroxyquinoline | Quantitative High-Throughput Screening Identifies 8-
Hydroxyquinolines as Cell-Active Histone Demethylase
Inhibitors
Oliver N. F. King1., Xuan Shirley Li2., Masaaki Sakurai3.¤a, Akane Kawamura4", Nathan R. Rose4",
Stanley S. Ng1, Amy M. Quinn3, Ganesha Rai3, Bryan T. Mott3, Paul Beswick1¤b, Robert J. Klose2, Udo
Opperm... |
3NK5 | Crystal structure of AqpZ mutant F43W | Structural context shapes the
aquaporin selectivity filter
David F. Savagea,b, Joseph D. O’Connell IIIb, Larry J. W. Mierckeb, Janet Finer-Mooreb, and Robert M. Strouda,b,1
aGraduate Group in Biophysics, and bDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2517
Edited by Pet... |
3NK9 | Crystal structure of Staphylococcal nuclease variant Delta+PHS V74A at cryogenic temperature | Cavities determine the pressure unfolding of proteins
Julien Rochea,1, Jose A. Carob,1, Douglas R. Norbertoa,c, Philippe Barthea, Christian Roumestanda, Jamie L. Schlessmand,
Angel E. Garciae, Bertrand García-Moreno E.b, and Catherine A. Royera,2
aCentre de Biochimie Structurale, Institut National pour la Santé et la R... |
3NKA | Crystal structure of AqpZ H174G,T183F | Structural context shapes the
aquaporin selectivity filter
David F. Savagea,b, Joseph D. O’Connell IIIb, Larry J. W. Mierckeb, Janet Finer-Mooreb, and Robert M. Strouda,b,1
aGraduate Group in Biophysics, and bDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2517
Edited by Pet... |
3NKC | Crystal structure of AqpZ F43W,H174G,T183F | Structural context shapes the
aquaporin selectivity filter
David F. Savagea,b, Joseph D. O’Connell IIIb, Larry J. W. Mierckeb, Janet Finer-Mooreb, and Robert M. Strouda,b,1
aGraduate Group in Biophysics, and bDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2517
Edited by Pet... |
3NKD | Structure of CRISP-associated protein Cas1 from Escherichia coli str. K-12 | A dual function of the CRISPR-Cas system in bacterial antivirus
immunity and DNA repair
Mohan Babu1,◆, Natalia Beloglazova1,◆, Robert Flick1, Chris Graham1, Tatiana Skarina1,
Boguslaw Nocek2, Alla Gagarinova1, Oxana Pogoutse1, Greg Brown1, Andrew
Binkowski2, Sadhna Phanse1, Andrzej Joachimiak2, Eugene V. Koonin3, Alexe... |
3NKE | High resolution structure of the C-terminal domain CRISP-associated protein Cas1 from Escherichia coli str. K-12 | A dual function of the CRISPR-Cas system in bacterial antivirus
immunity and DNA repair
Mohan Babu1,◆, Natalia Beloglazova1,◆, Robert Flick1, Chris Graham1, Tatiana Skarina1,
Boguslaw Nocek2, Alla Gagarinova1, Oxana Pogoutse1, Greg Brown1, Andrew
Binkowski2, Sadhna Phanse1, Andrzej Joachimiak2, Eugene V. Koonin3, Alexe... |
3NKF | Crystal structure of human ligand-free mature caspase-6 with intersubunit linker attached | Substrate-induced conformational changes occur in all cleaved
forms of caspase-6
Sravanti Vaidya, Elih M. Velázquez-Delgado, Genevieve Abbruzzese, and Jeanne A. Hardy*
Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003
Abstract
Caspase-6 is an apoptotic cysteine protease that also governs d... |
3NKX | Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome | MOLECULAR AND CELLULAR BIOLOGY, Oct. 2010, p. 4698–4711
Vol. 30, No. 19
0270-7306/10/$12.00
doi:10.1128/MCB.01636-09
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests
New Approaches in Diseases with Increased Ras Signaling
Manuela ... |
3NKY | Structure of a mutant P44S of Foot-and-mouth disease Virus RNA-dependent RNA polymerase | A Multi-Step Process of Viral Adaptation to a Mutagenic
Nucleoside Analogue by Modulation of Transition Types
Leads to Extinction-Escape
Rube´n Agudo1, Cristina Ferrer-Orta2, Armando Arias1¤, Ignacio de la Higuera1, Celia Perales1,3, Rosa
Pe´rez-Luque2, Nuria Verdaguer2, Esteban Domingo1,3*
1 Centro de Biologia Molecul... |
3NL0 | Mutant P44S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase | A Multi-Step Process of Viral Adaptation to a Mutagenic
Nucleoside Analogue by Modulation of Transition Types
Leads to Extinction-Escape
Rube´n Agudo1, Cristina Ferrer-Orta2, Armando Arias1¤, Ignacio de la Higuera1, Celia Perales1,3, Rosa
Pe´rez-Luque2, Nuria Verdaguer2, Esteban Domingo1,3*
1 Centro de Biologia Molecul... |
3NL2 | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Domain Organization in Candida glabrata THI6, a Bifunctional
Enzyme Required for Thiamin Biosynthesis in Eukaryotes†,||,‡
Debamita Paula, Abhishek Chatterjeeb, Tadhg P. Begleyb,*, and Steven E. Ealicka,*
a Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853
b Department of Chemistry, Texa... |
3NL3 | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Domain Organization in Candida glabrata THI6, a Bifunctional
Enzyme Required for Thiamin Biosynthesis in Eukaryotes†,||,‡
Debamita Paula, Abhishek Chatterjeeb, Tadhg P. Begleyb,*, and Steven E. Ealicka,*
a Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853
b Department of Chemistry, Texa... |
3NL5 | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Domain Organization in Candida glabrata THI6, a Bifunctional
Enzyme Required for Thiamin Biosynthesis in Eukaryotes†,||,‡
Debamita Paula, Abhishek Chatterjeeb, Tadhg P. Begleyb,*, and Steven E. Ealicka,*
a Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853
b Department of Chemistry, Texa... |
3NL6 | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Domain Organization in Candida glabrata THI6, a Bifunctional
Enzyme Required for Thiamin Biosynthesis in Eukaryotes†,||,‡
Debamita Paula, Abhishek Chatterjeeb, Tadhg P. Begleyb,*, and Steven E. Ealicka,*
a Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853
b Department of Chemistry, Texa... |
3NL7 | Human Hemoglobin A mutant beta H63W carbonmonoxy-form | Blocking the Gate to Ligand Entry in Human Hemoglobin*□
S
Received for publication,August 17, 2010, and in revised form, December 6, 2010 Published, JBC Papers in Press,December 29, 2010, DOI 10.1074/jbc.M110.176271
Ivan Birukou, Jayashree Soman, and John S. Olson1
From the Department of Biochemistry and Cell Biology a... |
3NL9 | Crystal structure of a putative NTP pyrophosphohydrolase (Exig_1061) from EXIGUOBACTERIUM SP. 255-15 at 1.78 A resolution | structural communications
Acta Cryst. (2010). F66, 1237–1244
doi:10.1107/S1744309110025534
1237
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Structure of a putative NTP pyrophosphohydrolase:
YP_001813558.1 from Exiguobacterium sibiricum
255-15
Gye Won Han,a,b Mar... |
3NLB | Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death | Context-Dependent Cell Cycle Checkpoint Abrogation by
a Novel Kinase Inhibitor
Andrew J. Massey*, Jenifer Borgognoni, Carol Bentley, Nicolas Foloppe, Andrea Fiumana, Lee Walmsley
Vernalis (R&D) Ltd., Granta Park, Cambridge, United Kingdom
Abstract
Background: Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinase... |
3NLD | Structure of endothelial nitric oxide synthase heme domain complexed with 6-{{(3'S,4'S)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLE | Structure of endothelial nitric oxide synthase heme domain complexed with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLF | Structure of endothelial nitric oxide synthase heme domain complexed with 6-{{(3'R,4'S)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLG | Structure of endothelial nitric oxide synthase heme domain complexed with 6-{{(3'S,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLH | Structure of endothelial nitric oxide synthase heme domain N368D mutant complexed with 6-{{(3'S,4'S)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLI | Structure of endothelial nitric oxide synthase N368D mutant heme domain complexed with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLJ | Structure of neuronal nitric oxide synthase D597N/M336V/Y706A triple mutant heme domain complexed with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy] pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLK | Structure of neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-{{(3'S,4'S)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLM | Structure of neuronal nitric oxide synthase heme domain in complex with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLN | Structure of neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-{{(3'R,4'S)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLO | Structure of neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-{{(3'S,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLP | Structure of neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with 6-{{(3'S,4'S)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLQ | Structure of neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLR | Structure of neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with 6-{{(3'R,4'S)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine | Exploration of the Active Site of Neuronal Nitric Oxide Synthase
by the Design and Synthesis of Pyrrolidinomethyl 2-
Aminopyridine Derivatives
Haitao Ji†, Silvia L. Delker‡, Huiying Li‡, Pavel Martásek§,¥, Linda J. Roman§, Thomas L.
Poulos*,‡, and Richard B. Silverman*,†
† Department of Chemistry, Department of Molecul... |
3NLT | Structure of endothelial nitric oxide synthase heme domain complexed with N1-{(3'S,4'S)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}- N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride | Potent, Highly Selective, and Orally Bioavailable Gem-
Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide
Synthase
Fengtian Xue1,5, Huiying Li2, Silvia L. Delker2, Jianguo Fang1, Pavel Martásek3,4, Linda J.
Roman3, Thomas L. Poulos2,*, and Richard B. Silverman1,*
1 Department of Chemistry, Department of Bio... |
3NLU | Structure of endothelial nitric oxide synthase heme domain complexed with N1-{(3'R,4'R)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride | Potent, Highly Selective, and Orally Bioavailable Gem-
Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide
Synthase
Fengtian Xue1,5, Huiying Li2, Silvia L. Delker2, Jianguo Fang1, Pavel Martásek3,4, Linda J.
Roman3, Thomas L. Poulos2,*, and Richard B. Silverman1,*
1 Department of Chemistry, Department of Bio... |
3NLV | Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3S,4S)-4-(2-(2,2-Difluoro-2-(3-fluorophenyl)ethylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine | Potent, Highly Selective, and Orally Bioavailable Gem-
Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide
Synthase
Fengtian Xue1,5, Huiying Li2, Silvia L. Delker2, Jianguo Fang1, Pavel Martásek3,4, Linda J.
Roman3, Thomas L. Poulos2,*, and Richard B. Silverman1,*
1 Department of Chemistry, Department of Bio... |
3NLW | Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3S,4S)-4-(2-(2,2-Difluoro-2-(piperidin-2-yl)ethylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine | Potent, Highly Selective, and Orally Bioavailable Gem-
Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide
Synthase
Fengtian Xue1,5, Huiying Li2, Silvia L. Delker2, Jianguo Fang1, Pavel Martásek3,4, Linda J.
Roman3, Thomas L. Poulos2,*, and Richard B. Silverman1,*
1 Department of Chemistry, Department of Bio... |
3NLX | Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2- (2,2-Difluoro-2-(3-fluorophenyl)ethylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine | Potent, Highly Selective, and Orally Bioavailable Gem-
Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide
Synthase
Fengtian Xue1,5, Huiying Li2, Silvia L. Delker2, Jianguo Fang1, Pavel Martásek3,4, Linda J.
Roman3, Thomas L. Poulos2,*, and Richard B. Silverman1,*
1 Department of Chemistry, Department of Bio... |
3NLY | Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2- (2,2-Difluoro-2-(4-fluorophenyl)ethylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine | Potent, Highly Selective, and Orally Bioavailable Gem-
Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide
Synthase
Fengtian Xue1,5, Huiying Li2, Silvia L. Delker2, Jianguo Fang1, Pavel Martásek3,4, Linda J.
Roman3, Thomas L. Poulos2,*, and Richard B. Silverman1,*
1 Department of Chemistry, Department of Bio... |
3NLZ | Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-(2,2-Difluoro-2-phenylethylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine | Potent, Highly Selective, and Orally Bioavailable Gem-
Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide
Synthase
Fengtian Xue1,5, Huiying Li2, Silvia L. Delker2, Jianguo Fang1, Pavel Martásek3,4, Linda J.
Roman3, Thomas L. Poulos2,*, and Richard B. Silverman1,*
1 Department of Chemistry, Department of Bio... |
3NM0 | Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-(2,2-Difluoro-2-phenylethylamino)ethoxy) pyrrolidin-3-yl)methyl)-4-methyl-3,4,5,6-tetrahydropyridin-2-amine | Potent, Highly Selective, and Orally Bioavailable Gem-
Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide
Synthase
Fengtian Xue1,5, Huiying Li2, Silvia L. Delker2, Jianguo Fang1, Pavel Martásek3,4, Linda J.
Roman3, Thomas L. Poulos2,*, and Richard B. Silverman1,*
1 Department of Chemistry, Department of Bio... |
3NM1 | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Domain Organization in Candida glabrata THI6, a Bifunctional
Enzyme Required for Thiamin Biosynthesis in Eukaryotes†,||,‡
Debamita Paula, Abhishek Chatterjeeb, Tadhg P. Begleyb,*, and Steven E. Ealicka,*
a Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853
b Department of Chemistry, Texa... |
3NM3 | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Domain Organization in Candida glabrata THI6, a Bifunctional
Enzyme Required for Thiamin Biosynthesis in Eukaryotes†,||,‡
Debamita Paula, Abhishek Chatterjeeb, Tadhg P. Begleyb,*, and Steven E. Ealicka,*
a Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853
b Department of Chemistry, Texa... |
3NM4 | Helicobacter pylori MTAN | Enzyme–ligand interactions that drive
active site rearrangements in the
Helicobacter pylori 50-methylthioadenosine/
S-adenosylhomocysteine nucleosidase
Donald R. Ronning,* Natalie M. Iacopelli, and Vidhi Mishra
Department of Chemistry, University of Toledo, Toledo, Ohio 43606
Received 1 July 2010; Accepted 24 September... |
3NM5 | Helicobacter pylori MTAN complexed with Formycin A | Enzyme–ligand interactions that drive
active site rearrangements in the
Helicobacter pylori 50-methylthioadenosine/
S-adenosylhomocysteine nucleosidase
Donald R. Ronning,* Natalie M. Iacopelli, and Vidhi Mishra
Department of Chemistry, University of Toledo, Toledo, Ohio 43606
Received 1 July 2010; Accepted 24 September... |
3NM6 | Helicobacter pylori MTAN complexed with adenine and tris | Enzyme–ligand interactions that drive
active site rearrangements in the
Helicobacter pylori 50-methylthioadenosine/
S-adenosylhomocysteine nucleosidase
Donald R. Ronning,* Natalie M. Iacopelli, and Vidhi Mishra
Department of Chemistry, University of Toledo, Toledo, Ohio 43606
Received 1 July 2010; Accepted 24 September... |
3NM9 | HMGD(M13A)-DNA complex | Structural Analysis of HMGD-DNA Complexes Reveal Influence
of Intercalation on Sequence Selectivity and DNA Bending
Mair E.A. Churchill1,2,*, Janet Klass1, and David L. Zoetewey2
1 Department of Pharmacology, The University of Colorado Denver, School of Medicine, Aurora,
CO 80045, USA
2 Molecular Biology Program, The U... |
3NMA | Mutant P169S of Foot-and-mouth disease Virus RNA dependent RNA-polymerase | A Multi-Step Process of Viral Adaptation to a Mutagenic
Nucleoside Analogue by Modulation of Transition Types
Leads to Extinction-Escape
Rube´n Agudo1, Cristina Ferrer-Orta2, Armando Arias1¤, Ignacio de la Higuera1, Celia Perales1,3, Rosa
Pe´rez-Luque2, Nuria Verdaguer2, Esteban Domingo1,3*
1 Centro de Biologia Molecul... |
3NMD | Crystal structure of the leucine zipper domain of cGMP dependent protein kinase I beta | A Crystal Structure of the Cyclic
GMP-dependent Protein Kinase
I Dimerization/Docking Domain
Reveals Molecular Details of
Isoform-specific Anchoring*□
S
Received for publication,July 5, 2010, and in revised form, July 30, 2010
Published, JBC Papers in Press,September 8, 2010, DOI 10.1074/jbc.C110.161430
Darren E. Cast... |
3NME | Structure of a plant phosphatase | Structural basis for the glucan phosphatase
activity of Starch Excess4
Craig W. Vander Kooia,1, Adam O. Taylora, Rachel M. Pacea, David A. Meekinsa, Hou-Fu Guoa,
Youngjun Kimb, and Matthew S. Gentrya,1
aMolecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Biomedical Biological ... |
3NMH | Crystal structure of the abscisic receptor PYL2 in complex with pyrabactin | Identification and Mechanism of ABA Receptor Antagonism
Karsten Melcher1,§,*, Yong Xu1,*, Ley-Moy Ng1,2,*, X. Edward Zhou1,*, Fen-Fen Soon1,2,*,
Viswanathan Chinnusamy3,4, Kelly M. Suino-Powell1, Amanda Kovach1, Fook S. Tham3,
Sean R. Cutler4, Jun Li1,2, Eu-Leong Yong2, Jian-Kang Zhu4,5, and H. Eric Xu1,§
1Laboratory... |
3NML | Sperm whale myoglobin mutant H64W carbonmonoxy-form | Blocking the Gate to Ligand Entry in Human Hemoglobin*□
S
Received for publication,August 17, 2010, and in revised form, December 6, 2010 Published, JBC Papers in Press,December 29, 2010, DOI 10.1074/jbc.M110.176271
Ivan Birukou, Jayashree Soman, and John S. Olson1
From the Department of Biochemistry and Cell Biology a... |
3NMM | Human Hemoglobin A mutant alpha H58W deoxy-form | Blocking the Gate to Ligand Entry in Human Hemoglobin*□
S
Received for publication,August 17, 2010, and in revised form, December 6, 2010 Published, JBC Papers in Press,December 29, 2010, DOI 10.1074/jbc.M110.176271
Ivan Birukou, Jayashree Soman, and John S. Olson1
From the Department of Biochemistry and Cell Biology a... |
3NMN | Crystal structure of pyrabactin-bound abscisic acid receptor PYL1 in complex with type 2C protein phosphatase ABI1 | Identification and Mechanism of ABA Receptor Antagonism
Karsten Melcher1,§,*, Yong Xu1,*, Ley-Moy Ng1,2,*, X. Edward Zhou1,*, Fen-Fen Soon1,2,*,
Viswanathan Chinnusamy3,4, Kelly M. Suino-Powell1, Amanda Kovach1, Fook S. Tham3,
Sean R. Cutler4, Jun Li1,2, Eu-Leong Yong2, Jian-Kang Zhu4,5, and H. Eric Xu1,§
1Laboratory... |
3NMO | Crystal structure of an engineered monomeric CLC-ec1 Cl-/H+ transporter | Design, function, and structure of a monomeric CLC transporter
Janice L. Robertson, Ludmila Kolmakova-Partensky, and Christopher Miller
Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham,
Massachusetts 02454
Abstract
Channels and transporters of the CLC family bring about transme... |
3NMP | Crystal structure of the abscisic receptor PYL2 mutant A93F in complex with pyrabactin | Identification and Mechanism of ABA Receptor Antagonism
Karsten Melcher1,§,*, Yong Xu1,*, Ley-Moy Ng1,2,*, X. Edward Zhou1,*, Fen-Fen Soon1,2,*,
Viswanathan Chinnusamy3,4, Kelly M. Suino-Powell1, Amanda Kovach1, Fook S. Tham3,
Sean R. Cutler4, Jun Li1,2, Eu-Leong Yong2, Jian-Kang Zhu4,5, and H. Eric Xu1,§
1Laboratory... |
3NMR | Crystal Structure of CUGBP1 RRM1/2-RNA Complex | Structural Insights into RNA Recognition by the Alternate-
splicing Regulator CUG Binding Protein 1
Marianna Teplova, Jikui Song, Hai Yan Gaw, Alexei Teplov, and Dinshaw J. Patel
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Abstract
CUG binding protein 1 (CUGBP1) regulates... |
3NMS | Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement C3c | Molecular Basis for Complement Recognition and Inhibition
Determined by Crystallographic Studies of the Staphylococcal
Complement Inhibitor (SCIN) Bound to C3c and C3b
Brandon L. Garcia1, Kasra X. Ramyar1, Apostolia Tzekou2, Daniel Ricklin2, William J.
McWhorter1, John D. Lambris2, and Brian V. Geisbrecht1,*
1 Division... |
3NMT | Crystal structure of pyrabactin bound abscisic acid receptor PYL2 mutant A93F in complex with type 2C protein phosphatase HAB1 | Identification and Mechanism of ABA Receptor Antagonism
Karsten Melcher1,§,*, Yong Xu1,*, Ley-Moy Ng1,2,*, X. Edward Zhou1,*, Fen-Fen Soon1,2,*,
Viswanathan Chinnusamy3,4, Kelly M. Suino-Powell1, Amanda Kovach1, Fook S. Tham3,
Sean R. Cutler4, Jun Li1,2, Eu-Leong Yong2, Jian-Kang Zhu4,5, and H. Eric Xu1,§
1Laboratory... |
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