protein_name stringlengths 4 4 | structure_title stringlengths 3 322 | main_text stringlengths 0 302k |
|---|---|---|
3MF8 | Crystal Structure of Native cis-CaaD | Crystal Structures of Native and Inactivated cis-3-Chloroacrylic
Acid Dehalogenase: Implications for the Catalytic and
Inactivation Mechanisms†
Youzhong Guoa, Hector Serranoa, William H. Johnson Jr.a, Stephen Ernstb, Marvin L.
Hackertb,*, and Christian P. Whitmana,*
Department of Chemistry and Biochemistry and Division... |
3MF9 | Computationally designed endo-1,4-beta-xylanase | Computational design of an endo-1,4-b-xylanase ligand
binding site
Andrew Morin1, Kristian W.Kaufmann1,
Carie Fortenberry1, Joel M.Harp 2, Laura S.Mizoue 2 and
Jens Meiler 1,3
1Department of Chemistry, Vanderbilt University, Nashville, TN 37235,
USA and 2Department of Biochemistry, Vanderbilt University School of
Medic... |
3MFA | Computationally designed endo-1,4-beta-xylanase | Computational design of an endo-1,4-b-xylanase ligand
binding site
Andrew Morin1, Kristian W.Kaufmann1,
Carie Fortenberry1, Joel M.Harp 2, Laura S.Mizoue 2 and
Jens Meiler 1,3
1Department of Chemistry, Vanderbilt University, Nashville, TN 37235,
USA and 2Department of Biochemistry, Vanderbilt University School of
Medic... |
3MFC | Computationally designed end0-1,4-beta,xylanase | Computational design of an endo-1,4-b-xylanase ligand
binding site
Andrew Morin1, Kristian W.Kaufmann1,
Carie Fortenberry1, Joel M.Harp 2, Laura S.Mizoue 2 and
Jens Meiler 1,3
1Department of Chemistry, Vanderbilt University, Nashville, TN 37235,
USA and 2Department of Biochemistry, Vanderbilt University School of
Medic... |
3MFE | Crystal Structure of Mycobacterium Tuberculosis Proteasome open-gate mutant with H0 movement | Structural basis for the assembly and gate closure
mechanisms of the Mycobacterium tuberculosis
20S proteasome
Dongyang Li1,4, Hua Li1,4, Tao Wang1,
Hong Pan2, Gang Lin3 and Huilin Li1,2,*
1Department of Biology, Brookhaven National Laboratory, Upton,
NY, USA, 2Department of Biochemistry and Cell Biology, Stony Brook
U... |
3MFH | DNA Polymerase Eta in Complex With Undamaged DNA | Structural basis for the suppression of skin cancers by DNA
polymerase η
Timothy D. Silverstein1, Robert E. Johnson2, Rinku Jain1, Louise Prakash2, Satya
Prakash2,*, and Aneel K. Aggarwal1,*
1Department of Structural and Chemical Biology Mount Sinai School of Medicine Box 1677 1425
Madison Avenue New York, NY 10029
2De... |
3MFI | DNA Polymerase Eta in Complex With a cis-syn Thymidine Dimer | Structural basis for the suppression of skin cancers by DNA
polymerase η
Timothy D. Silverstein1, Robert E. Johnson2, Rinku Jain1, Louise Prakash2, Satya
Prakash2,*, and Aneel K. Aggarwal1,*
1Department of Structural and Chemical Biology Mount Sinai School of Medicine Box 1677 1425
Madison Avenue New York, NY 10029
2De... |
3MFK | Ets1 complex with stromelysin-1 promoter DNA | Cell Cycle 9:15, 3054-3062; August 1, 2010; © 2010 Landes Bioscience
Report
3054
Cell Cycle
Volume 9 Issue 15
*Correspondence to: Tahir H. Tahirov; Email: ttahirov@unmc.edu
Submitted: 04/30/10; Accepted: 05/05/10
Previously published online: www.landesbioscience.com/journals/cc/article/12257
DOI: 10.4161/cc.9.15.122... |
3MFM | Crystal Structures and Mutational Analyses of Acyl-CoA Carboxylase Subunit of Streptomyces coelicolor | Crystal Structures and Mutational Analyses of Acyl-CoA
Carboxylase β Subunit of Streptomyces coelicolor
Ana Arabolaza*,2, Mary Elizabeth Shillito*,1, Ting-Wan Lin1, Lautaro Diacovich2, Melrose
Melgar1, Huy Pham1, Deborah Amick1, Hugo Gramajo2, and Shiou-Chuan Tsai1
1Department of Molecular Biology and Biochemistry, Dep... |
3MFQ | A Glance into the Metal Binding Specificity of TroA: Where Elaborate Behaviors Occur in the Active Center | Insight into the Interaction of Metal Ions with TroA from
Streptococcus suis
Beiwen Zheng1,2, Qiangmin Zhang1, Jia Gao1,3, Huiming Han1,2, Ming Li1, Jingren Zhang4, Jianxun Qi1,
Jinghua Yan1, George F. Gao1,2,5*
1 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy o... |
3MFR | CASK-4M CaM Kinase Domain, native | Evolution of CASK into a Mg2+-sensitive kinase
Konark Mukherjee1,4,*, Manu Sharma1, Reinhard Jahn2, Markus C. Wahl3,*, and Thomas C.
Südhof1,*
1Dept. of Mol. and Cellular Physiology Stanford University School of Medicine 1050 Arastradero
Rd. Palo Alto, CA 94304, USA
2Max-Planck-Institut für Biophysikalische Chemie Neur... |
3MFS | CASK-4M CaM Kinase Domain, AMPPNP | Evolution of CASK into a Mg2+-sensitive kinase
Konark Mukherjee1,4,*, Manu Sharma1, Reinhard Jahn2, Markus C. Wahl3,*, and Thomas C.
Südhof1,*
1Dept. of Mol. and Cellular Physiology Stanford University School of Medicine 1050 Arastradero
Rd. Palo Alto, CA 94304, USA
2Max-Planck-Institut für Biophysikalische Chemie Neur... |
3MFT | CASK-4M CaM Kinase Domain, Mn2+ | Evolution of CASK into a Mg2+-sensitive kinase
Konark Mukherjee1,4,*, Manu Sharma1, Reinhard Jahn2, Markus C. Wahl3,*, and Thomas C.
Südhof1,*
1Dept. of Mol. and Cellular Physiology Stanford University School of Medicine 1050 Arastradero
Rd. Palo Alto, CA 94304, USA
2Max-Planck-Institut für Biophysikalische Chemie Neur... |
3MFU | CASK-4M CaM Kinase Domain, AMPPNP-Mn2+ | Evolution of CASK into a Mg2+-sensitive kinase
Konark Mukherjee1,4,*, Manu Sharma1, Reinhard Jahn2, Markus C. Wahl3,*, and Thomas C.
Südhof1,*
1Dept. of Mol. and Cellular Physiology Stanford University School of Medicine 1050 Arastradero
Rd. Palo Alto, CA 94304, USA
2Max-Planck-Institut für Biophysikalische Chemie Neur... |
3MFV | Crystal structure of human arginase I in complex with 2-aminohomohistidine | 2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear
Manganese Metalloenzyme Human Arginase I
Monica Ilies†, Luigi Di Costanzo†,§, Michelle L. North‡, Jeremy A. Scott‡, and David W.
Christianson*,†
† Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania,
Philadelphia, PA 19104-6... |
3MFW | Crystal structure of human arginase I in complex with L-2-aminohistidine and sulphate | 2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear
Manganese Metalloenzyme Human Arginase I
Monica Ilies†, Luigi Di Costanzo†,§, Michelle L. North‡, Jeremy A. Scott‡, and David W.
Christianson*,†
† Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania,
Philadelphia, PA 19104-6... |
3MG0 | Structure of yeast 20S proteasome with bortezomib | Biochem. J. (2010) 430, 461–476 (Printed in Great Britain)
doi:10.1042/BJ20100383
461
Characterization of a new series of non-covalent proteasome inhibitors with
exquisite potency and selectivity for the 20S β5-subunit
Christopher BLACKBURN, Kenneth M. GIGSTAD, Paul HALES, Khristofer GARCIA, Matthew JONES, Frank J. BRU... |
3MG1 | Crystal structure of the orange carotenoid protein from cyanobacteria Synechocystis sp. PCC 6803 | Structural Determinants Underlying Photoprotection in the
Photoactive Orange Carotenoid Protein of Cyanobacteria
□
S
Received for publication,February 22, 2010, and in revised form, March 21, 2010 Published, JBC Papers in Press,April 5, 2010, DOI 10.1074/jbc.M110.115709
Adjele Wilson‡§1, James N. Kinney¶2, Petrus H. Zw... |
3MG2 | Crystal structure of the orange carotenoid protein Y44S mutant from cyanobacteria synechocystis sp. PCC 6803 | Structural Determinants Underlying Photoprotection in the
Photoactive Orange Carotenoid Protein of Cyanobacteria
□
S
Received for publication,February 22, 2010, and in revised form, March 21, 2010 Published, JBC Papers in Press,April 5, 2010, DOI 10.1074/jbc.M110.115709
Adjele Wilson‡§1, James N. Kinney¶2, Petrus H. Zw... |
3MG3 | Crystal structure of the orange carotenoid protein R155L mutant from cyanobacteria synechocystis sp. PCC 6803 | Structural Determinants Underlying Photoprotection in the
Photoactive Orange Carotenoid Protein of Cyanobacteria
□
S
Received for publication,February 22, 2010, and in revised form, March 21, 2010 Published, JBC Papers in Press,April 5, 2010, DOI 10.1074/jbc.M110.115709
Adjele Wilson‡§1, James N. Kinney¶2, Petrus H. Zw... |
3MG4 | Structure of yeast 20S proteasome with Compound 1 | Biochem. J. (2010) 430, 461–476 (Printed in Great Britain)
doi:10.1042/BJ20100383
461
Characterization of a new series of non-covalent proteasome inhibitors with
exquisite potency and selectivity for the 20S β5-subunit
Christopher BLACKBURN, Kenneth M. GIGSTAD, Paul HALES, Khristofer GARCIA, Matthew JONES, Frank J. BRU... |
3MG5 | Core-streptavidin mutant F130L in complex with biotin | A Distal Point Mutation in the Streptavidin-biotin Complex
Preserves Structure but Diminishes Binding Affinity:
Experimental Evidence for Electronic Polarization Effects?
Loren Baugh‡, Isolde Le Trong, David S. Cerutti§, Susanne Gülich‡, Patrick S. Stayton‡,
Ronald E. Stenkamp&, and Terry P. Lybrand*,§
Departments of B... |
3MG6 | Structure of yeast 20S open-gate proteasome with Compound 6 | Biochem. J. (2010) 430, 461–476 (Printed in Great Britain)
doi:10.1042/BJ20100383
461
Characterization of a new series of non-covalent proteasome inhibitors with
exquisite potency and selectivity for the 20S β5-subunit
Christopher BLACKBURN, Kenneth M. GIGSTAD, Paul HALES, Khristofer GARCIA, Matthew JONES, Frank J. BRU... |
3MG7 | Structure of yeast 20S open-gate proteasome with Compound 8 | Biochem. J. (2010) 430, 461–476 (Printed in Great Britain)
doi:10.1042/BJ20100383
461
Characterization of a new series of non-covalent proteasome inhibitors with
exquisite potency and selectivity for the 20S β5-subunit
Christopher BLACKBURN, Kenneth M. GIGSTAD, Paul HALES, Khristofer GARCIA, Matthew JONES, Frank J. BRU... |
3MG8 | Structure of yeast 20S open-gate proteasome with Compound 16 | Biochem. J. (2010) 430, 461–476 (Printed in Great Britain)
doi:10.1042/BJ20100383
461
Characterization of a new series of non-covalent proteasome inhibitors with
exquisite potency and selectivity for the 20S β5-subunit
Christopher BLACKBURN, Kenneth M. GIGSTAD, Paul HALES, Khristofer GARCIA, Matthew JONES, Frank J. BRU... |
3MG9 | Teg 12 Binary Structure Complexed with the Teicoplanin Aglycone | Crystal Structures of the Glycopeptide Sulfotransferase Teg12
Complexed with the Teicoplanin Aglycone
Matthew J. Bick, Jacob J. Banik, Seth A. Darst, and Sean F. Brady*
Howard Hughes Medical Institute, Laboratory of Genetically Encoded Small Molecules, Laboratory
of Molecular Biophysics, The Rockefeller University, 123... |
3MGB | Teg 12 Ternary Structure Complexed with PAP and the Teicoplanin Aglycone | Crystal Structures of the Glycopeptide Sulfotransferase Teg12
Complexed with the Teicoplanin Aglycone
Matthew J. Bick, Jacob J. Banik, Seth A. Darst, and Sean F. Brady*
Howard Hughes Medical Institute, Laboratory of Genetically Encoded Small Molecules, Laboratory
of Molecular Biophysics, The Rockefeller University, 123... |
3MGC | Teg12 Apo | Crystal Structures of the Glycopeptide Sulfotransferase Teg12
Complexed with the Teicoplanin Aglycone
Matthew J. Bick, Jacob J. Banik, Seth A. Darst, and Sean F. Brady*
Howard Hughes Medical Institute, Laboratory of Genetically Encoded Small Molecules, Laboratory
of Molecular Biophysics, The Rockefeller University, 123... |
3MGE | X-ray Structure of Hexameric HIV-1 CA | Disulfide bond stabilization of the hexameric capsomer of
human immunodeficiency virus
Owen Pornillos1,2, Barbie K. Ganser-Pornillos1,2, Sankaran Banumathi3, Yuanzi Hua2, and
Mark Yeager1,2,*
1Department of Molecular Physiology and Biological Physics, University of Virginia,
Charlottesville, VA 22908, USA
2Department o... |
3MGH | Binary complex of a DNA polymerase lambda loop mutant | Loop 1 modulates the fidelity of DNA polymerase j
Katarzyna Bebenek1,2, Miguel Garcia-Diaz1,2, Rui-Zhe Zhou3, Lawrence F. Povirk3 and
Thomas A. Kunkel1,2,*
1Laboratory of Molecular Genetics, 2Laboratory of Structural Biology, National Institute of Environmental Health
Sciences, NIH, DHHS, Research Triangle Park, NC and... |
3MGI | Ternary complex of a DNA polymerase lambda loop mutant | Loop 1 modulates the fidelity of DNA polymerase j
Katarzyna Bebenek1,2, Miguel Garcia-Diaz1,2, Rui-Zhe Zhou3, Lawrence F. Povirk3 and
Thomas A. Kunkel1,2,*
1Laboratory of Molecular Genetics, 2Laboratory of Structural Biology, National Institute of Environmental Health
Sciences, NIH, DHHS, Research Triangle Park, NC and... |
3MGN | D-Peptide inhibitor PIE71 in complex with IQN17 | JOURNAL OF VIROLOGY, Nov. 2010, p. 11235–11244
Vol. 84, No. 21
0022-538X/10/$12.00
doi:10.1128/JVI.01339-10
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Design of a Potent D-Peptide HIV-1 Entry Inhibitor
with a Strong Barrier to Resistance
Brett D. Welch,1† J. Nicholas Francis,1† Joseph S.... |
3MGO | Crystal structure of a H5-specific CTL epitope derived from H5N1 influenza virus in complex with HLA-A*0201 | Identification and structural definition of H5-specific
CTL epitopes restricted by HLA-A*0201 derived
from the H5N1 subtype of influenza A viruses
Yeping Sun,1,2 Jun Liu,1,2 Meng Yang,1 Feng Gao,1,3 Jianfang Zhou,4
Yoshihiro Kitamura,1,5,6 Bin Gao,1,2,6 Po Tien,1 Yuelong Shu,4
Aikichi Iwamoto,5,6 Zhu Chen7 and George F... |
3MGP | Binding of Cobalt ions to the Nucleosome Core Particle | Perturbations in nucleosome structure from
heavy metal association
Kareem Mohideen, Reyhan Muhammad and Curt A. Davey*
Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological
University, 60 Nanyang Drive, Singapore 637551
Received April 9, 2010; Revised May 4, 2010; Accept... |
3MGQ | Binding of Nickel ions to the Nucleosome Core Particle | Perturbations in nucleosome structure from
heavy metal association
Kareem Mohideen, Reyhan Muhammad and Curt A. Davey*
Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological
University, 60 Nanyang Drive, Singapore 637551
Received April 9, 2010; Revised May 4, 2010; Accept... |
3MGR | Binding of Rubidium ions to the Nucleosome Core Particle | Perturbations in nucleosome structure from
heavy metal association
Kareem Mohideen, Reyhan Muhammad and Curt A. Davey*
Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological
University, 60 Nanyang Drive, Singapore 637551
Received April 9, 2010; Revised May 4, 2010; Accept... |
3MGS | Binding of Cesium ions to the Nucleosome Core particle | Perturbations in nucleosome structure from
heavy metal association
Kareem Mohideen, Reyhan Muhammad and Curt A. Davey*
Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological
University, 60 Nanyang Drive, Singapore 637551
Received April 9, 2010; Revised May 4, 2010; Accept... |
3MGT | Crystal structure of a H5-specific CTL epitope variant derived from H5N1 influenza virus in complex with HLA-A*0201 | Identification and structural definition of H5-specific
CTL epitopes restricted by HLA-A*0201 derived
from the H5N1 subtype of influenza A viruses
Yeping Sun,1,2 Jun Liu,1,2 Meng Yang,1 Feng Gao,1,3 Jianfang Zhou,4
Yoshihiro Kitamura,1,5,6 Bin Gao,1,2,6 Po Tien,1 Yuelong Shu,4
Aikichi Iwamoto,5,6 Zhu Chen7 and George F... |
3MGV | Cre recombinase-DNA transition state | Requirements for catalysis in the Cre
recombinase active site
Bryan Gibb, Kushol Gupta, Kaushik Ghosh, Robert Sharp, James Chen and
Gregory D. Van Duyne*
Department of Biochemistry and Biophysics and Howard Hughes Medical Institute,
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Received Apr... |
3MGX | Crystal Structure of P450 OxyD that is involved in the Biosynthesis of Vancomycin-type Antibiotics | Structural Characterization of OxyD, a Cytochrome P450
Involved in -Hydroxytyrosine Formation in Vancomycin
Biosynthesis
□
S
Received for publication,April 8, 2010, and in revised form, May 19, 2010 Published, JBC Papers in Press,June 1, 2010, DOI 10.1074/jbc.M110.131904
Max J. Cryle1, Anton Meinhart, and Ilme Schlich... |
3MH8 | Crystal structure of LprG from Mycobacterium tuberculosis | Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds
triacylated glycolipid agonists of Toll-like receptor 2
Michael G. Drage1,6, Han-Chun Tsai4,6, Nicole D. Pecora1,6, Tan-Yun Cheng5, Ahmad R.
Arida1,2, Supriya Shukla1, Roxana E. Rojas3, Chetan Seshadri5, D. Branch Moody5, W.
Henry Boom3,7, James C. Sacchett... |
3MH9 | Crystal structure of LprG mutant V91W from Mycobacterium tuberculosis | Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds
triacylated glycolipid agonists of Toll-like receptor 2
Michael G. Drage1,6, Han-Chun Tsai4,6, Nicole D. Pecora1,6, Tan-Yun Cheng5, Ahmad R.
Arida1,2, Supriya Shukla1, Roxana E. Rojas3, Chetan Seshadri5, D. Branch Moody5, W.
Henry Boom3,7, James C. Sacchett... |
3MHA | Crystal structure of LprG from Mycobacterium tuberculosis bound to PIM | Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds
triacylated glycolipid agonists of Toll-like receptor 2
Michael G. Drage1,6, Han-Chun Tsai4,6, Nicole D. Pecora1,6, Tan-Yun Cheng5, Ahmad R.
Arida1,2, Supriya Shukla1, Roxana E. Rojas3, Chetan Seshadri5, D. Branch Moody5, W.
Henry Boom3,7, James C. Sacchett... |
3MHB | Crystal structure of Staphylococcal nuclease variant Delta+PHS L38A at cryogenic temperature | Cavities determine the pressure unfolding of proteins
Julien Rochea,1, Jose A. Carob,1, Douglas R. Norbertoa,c, Philippe Barthea, Christian Roumestanda, Jamie L. Schlessmand,
Angel E. Garciae, Bertrand García-Moreno E.b, and Catherine A. Royera,2
aCentre de Biochimie Structurale, Institut National pour la Santé et la R... |
3MHD | Crystal structure of DCR3 | Decoy Strategies: The Structure of TL1A:DcR3 complex
Chenyang Zhan1, Yury Patskovsky1, Qingrong Yan2, Zhenhong Li1, Udupi Ramagopal1,
Huiyong Cheng1, Michael Brenowitz1, Xiao Hui3, Stanley G. Nathenson2,4, and Steven C.
Almo1,5
1Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
2Depa... |
3MHF | Tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes | Structure of a Class I Tagatose-1,6-bisphosphate Aldolase
INVESTIGATION INTO AN APPARENT LOSS OF STEREOSPECIFICITY*□
S
Received for publication,November 6, 2009, and in revised form, February 28, 2010 Published, JBC Papers in Press,April 28, 2010, DOI 10.1074/jbc.M109.080358
Clotilde LowKam, Brigitte Liotard, and Jurge... |
3MHG | Dihydroxyacetone phosphate carbanion intermediate in tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes | Structure of a Class I Tagatose-1,6-bisphosphate Aldolase
INVESTIGATION INTO AN APPARENT LOSS OF STEREOSPECIFICITY*□
S
Received for publication,November 6, 2009, and in revised form, February 28, 2010 Published, JBC Papers in Press,April 28, 2010, DOI 10.1074/jbc.M109.080358
Clotilde LowKam, Brigitte Liotard, and Jurge... |
3MHH | Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module | STRUCTURAL INSIGHTS INTO THE ASSEMBLY AND FUNCTION
OF THE SAGA DEUBIQUITINATING MODULE
Nadine L. Samara1,*, Ajit B. Datta1,2,*, Christopher E. Berndsen1,2, Xiangbin Zhang1,2,
Tingting Yao3, Robert E. Cohen3, and Cynthia Wolberger1,2
1Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University Sch... |
3MHP | FNR-recruitment to the thylakoid | Ferredoxin:NADPH oxidoreductase is recruited to
thylakoids by binding to a polyproline type II
helix in a pH-dependent manner
Ferdinand Altea,b, Anna Stengela,c, J. Philipp Benza,c,1, Eike Petersena,c, Jürgen Solla,c, Michael Grolla,b,2, and Bettina Böltera,c,2
aMunich Center for Integrated Protein Science, Ludwig-Maxi... |
3MHR | 14-3-3 sigma in complex with YAP pS127-peptide | structural communications
978
doi:10.1107/S1744309110025479
Acta Cryst. (2010). F66, 978–984
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Structure of a 14-3-3r–YAP phosphopeptide
complex at 1.15 A˚ resolution
Benjamin Schumacher,
Malgorzata Skwarczynska, Rolf
Ro... |
3MHS | Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to ubiquitin aldehyde | STRUCTURAL INSIGHTS INTO THE ASSEMBLY AND FUNCTION
OF THE SAGA DEUBIQUITINATING MODULE
Nadine L. Samara1,*, Ajit B. Datta1,2,*, Christopher E. Berndsen1,2, Xiangbin Zhang1,2,
Tingting Yao3, Robert E. Cohen3, and Cynthia Wolberger1,2
1Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University Sch... |
3MHV | Crystal Structure of Vps4 and Vta1 | Structural role of the Vps4-Vta1 interface in ESCRT-III recycling
Dong Yang1 and James H. Hurley
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney
Diseases, National Institutes of Health, U.S. Department of Health and Human Services,
Bethesda, MD 20892
SUMMARY
The ESCRT complexes ... |
3MHX | Crystal Structure of Stenotrophomonas maltophilia FeoA complexed with Zinc: A Unique Procaryotic SH3 Domain Protein Possibly Acting as a Bacterial Ferrous Iron Transport Activating Factor | structural communications
636
doi:10.1107/S1744309110013941
Acta Cryst. (2010). F66, 636–642
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Structure of Stenotrophomonas maltophilia FeoA
complexed with zinc: a unique prokaryotic
SH3-domain protein that possibly act... |
3MHZ | 1.7A structure of 2-fluorohistidine labeled Protective Antigen | Evidence that histidine protonation of receptor-bound anthrax
protective antigen is a trigger for pore formation
D. Shyamali Wimalasena‡, Blythe E. Janowiak*, Scott Lovell†, Masaru Miyagi§, Jianjun
Sun*,2, Haiying Zhou‡,3, Jan Hajduch#, Chaya Pooput#, Kenneth L. Kirk#, Kevin P. Battaileξ,
and James G. Bann‡,1
‡ Departm... |
3MI0 | Crystal Structure of Mycobacterium Tuberculosis Proteasome at 2.2 A | Structural basis for the assembly and gate closure
mechanisms of the Mycobacterium tuberculosis
20S proteasome
Dongyang Li1,4, Hua Li1,4, Tao Wang1,
Hong Pan2, Gang Lin3 and Huilin Li1,2,*
1Department of Biology, Brookhaven National Laboratory, Upton,
NY, USA, 2Department of Biochemistry and Cell Biology, Stony Brook
U... |
3MI2 | Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate | Structural Determinants for Inhibitory Ligands of Orotidine-5′-
Monophosphate Decarboxylase
Maria Elena Meza-Avina1,6, Lianhu Wei1, Yan Liu4, Ewa Poduch1, Angelica M. Bello1, Ram
K. Mishra1, Emil F. Pai1,3,4,*, and Lakshmi P. Kotra1,2,5,6,*
1 Center for Molecular Design and Preformulations and Division of Cell & Molecu... |
3MI3 | Homocitrate Synthase Lys4 bound to Lysine | Structural Basis for L-Lysine Feedback Inhibition of
Homocitrate Synthase*□
S
Received for publication,December 11, 2009, and in revised form, January 12, 2010 Published, JBC Papers in Press,January 19, 2010, DOI 10.1074/jbc.M109.094383
Stacie L. Bulfer‡1, Erin M. Scott§2, Lorraine Pillus§, and Raymond C. Trievel‡3
F... |
3MI8 | The structure of TL1A-DCR3 COMPLEX | Decoy Strategies: The Structure of TL1A:DcR3 complex
Chenyang Zhan1, Yury Patskovsky1, Qingrong Yan2, Zhenhong Li1, Udupi Ramagopal1,
Huiyong Cheng1, Michael Brenowitz1, Xiao Hui3, Stanley G. Nathenson2,4, and Steven C.
Almo1,5
1Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
2Depa... |
3MI9 | Crystal structure of HIV-1 Tat complexed with human P-TEFb | Crystal structure of HIV-1 Tat complexed with human P-TEFb
Tahir H. Tahirov1, Nigar D. Babayeva1, Katayoun Varzavand2, Jeffrey J. Cooper2, Stanley
C. Sedore2, and David H. Price2
1Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical
Center, Omaha, NE 68198-7696, USA.
2Biochemist... |
3MIA | Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb | Crystal structure of HIV-1 Tat complexed with human P-TEFb
Tahir H. Tahirov1, Nigar D. Babayeva1, Katayoun Varzavand2, Jeffrey J. Cooper2, Stanley
C. Sedore2, and David H. Price2
1Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical
Center, Omaha, NE 68198-7696, USA.
2Biochemist... |
3MIB | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite | Differential Reactivity Between Two Copper Sites in
Peptidylglycine α-Hydroxylating Monooxygenase (PHM)
Eduardo E. Chufán1, Sean T. Prigge2, Xavier Siebert1, Betty A. Eipper3, Richard E. Mains3,
and L. Mario Amzel1,*
1Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Johns
Hopkins Un... |
3MIC | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained by co-crystallization | Differential Reactivity Between Two Copper Sites in
Peptidylglycine α-Hydroxylating Monooxygenase (PHM)
Eduardo E. Chufán1, Sean T. Prigge2, Xavier Siebert1, Betty A. Eipper3, Richard E. Mains3,
and L. Mario Amzel1,*
1Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Johns
Hopkins Un... |
3MID | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained by soaking (100mM NaN3) | Differential Reactivity Between Two Copper Sites in
Peptidylglycine α-Hydroxylating Monooxygenase (PHM)
Eduardo E. Chufán1, Sean T. Prigge2, Xavier Siebert1, Betty A. Eipper3, Richard E. Mains3,
and L. Mario Amzel1,*
1Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Johns
Hopkins Un... |
3MIE | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained by soaking (50mM NaN3) | Differential Reactivity Between Two Copper Sites in
Peptidylglycine α-Hydroxylating Monooxygenase (PHM)
Eduardo E. Chufán1, Sean T. Prigge2, Xavier Siebert1, Betty A. Eipper3, Richard E. Mains3,
and L. Mario Amzel1,*
1Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Johns
Hopkins Un... |
3MIF | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound carbon monooxide (CO) | Differential Reactivity Between Two Copper Sites in
Peptidylglycine α-Hydroxylating Monooxygenase (PHM)
Eduardo E. Chufán1, Sean T. Prigge2, Xavier Siebert1, Betty A. Eipper3, Richard E. Mains3,
and L. Mario Amzel1,*
1Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Johns
Hopkins Un... |
3MIG | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite, obtained in the presence of substrate | Differential Reactivity Between Two Copper Sites in
Peptidylglycine α-Hydroxylating Monooxygenase (PHM)
Eduardo E. Chufán1, Sean T. Prigge2, Xavier Siebert1, Betty A. Eipper3, Richard E. Mains3,
and L. Mario Amzel1,*
1Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Johns
Hopkins Un... |
3MIH | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide, obtained in the presence of substrate | Differential Reactivity Between Two Copper Sites in
Peptidylglycine α-Hydroxylating Monooxygenase (PHM)
Eduardo E. Chufán1, Sean T. Prigge2, Xavier Siebert1, Betty A. Eipper3, Richard E. Mains3,
and L. Mario Amzel1,*
1Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Johns
Hopkins Un... |
3MII | Crystal structure of Y0R391Cp/HSP33 from Saccharomyces cerevisiae | structural communications
Acta Cryst. (2010). F66, 1557–1561
doi:10.1107/S1744309110039965
1557
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Structure of Hsp33/YOR391Cp from the yeast
Saccharomyces cerevisiae
Peng-Chao Guo, Ye-Yun Zhou,
Xiao-Xiao Ma and Wei-Fang ... |
3MIP | I-MsoI re-designed for altered DNA cleavage specificity (-8GCG) | Computational reprogramming of homing
endonuclease specificity at multiple
adjacent base pairs
Justin Ashworth1,2,*, Gregory K. Taylor3,4, James J. Havranek5, S. Arshiya Quadri1,
Barry L. Stoddard4 and David Baker1,6,*
1Department of Biochemistry, 2Graduate Program in Biomolecular Structure and Design, 3Graduate Progra... |
3MIS | I-MsoI re-designed for altered DNA cleavage specificity (-8G) | Computational reprogramming of homing
endonuclease specificity at multiple
adjacent base pairs
Justin Ashworth1,2,*, Gregory K. Taylor3,4, James J. Havranek5, S. Arshiya Quadri1,
Barry L. Stoddard4 and David Baker1,6,*
1Department of Biochemistry, 2Graduate Program in Biomolecular Structure and Design, 3Graduate Progra... |
3MIX | Crystal structure of the cytosolic domain of B. subtilis FlhA | FlhA provides the adaptor for coordinated
delivery of late flagella building blocks
to the type III secretion system
Gert Bange1, Nico Kümmerer1, Christoph Engel, Gunes Bozkurt, Klemens Wild, and Irmgard Sinning2
Biochemie-Zentrum der Universität Heidelberg, INF328, 69120 Heidelberg, Germany
Edited* by Peter Walter, Un... |
3MJ3 | Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to selenate | REPORT
Identification and characterization of anion binding
sites in RNA
JEFFREY S. KIEFT,1 ELAINE CHASE,2 DAVID A. COSTANTINO,1 and BARBARA L. GOLDEN2
1Howard Hughes Medical Institute and Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine,
Aurora, Colorado, 80045, USA
2Departm... |
3MJ5 | Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation | Severe Acute Respiratory Syndrome-Coronavirus Papain-Like
Novel Protease Inhibitors: Design, Synthesis, Protein-Ligand X-
ray Structure and Biological Evaluation
Arun K. Ghosh*,†, Jun Takayama†, Kalapala Venkateswara Rao†, Kiira Ratia≠, Rima
Chaudhuri≠, Debbie C. Mulhearn≠, Hyun Lee≠, Daniel B. Nichols⊥, Surendranath B... |
3MJ6 | Crystal structure of the gammadelta T cell costimulatory receptor Junctional Adhesion Molecule-Like Protein, JAML | The molecular interaction of CAR and JAML recruits the central
cell signal transducer PI3K
Petra Verdino1, Deborah A. Witherden2, Wendy L. Havran2, and Ian A. Wilson1,3,*
1Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines
Road, La Jolla, California 92037, USA
2Department of Immun... |
3MJ7 | Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR | The molecular interaction of CAR and JAML recruits the central
cell signal transducer PI3K
Petra Verdino1, Deborah A. Witherden2, Wendy L. Havran2, and Ian A. Wilson1,3,*
1Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines
Road, La Jolla, California 92037, USA
2Department of Immun... |
3MJ8 | Crystal structure of HL4E10 Fab, a hamster Ab stimulatory for gammadelta T cells | cDNA Sequence and Fab Crystal Structure of HL4E10, a
Hamster IgG Lambda Light Chain Antibody Stimulatory
for cd T Cells
Petra Verdino1, Deborah A. Witherden2, Katie Podshivalova2, Stephanie E. Rieder2, Wendy L. Havran2,
Ian A. Wilson1,3*
1 Department of Molecular Biology, The Scripps Research Institute, La Jolla, Calif... |
3MJ9 | Crystal structure of JAML in complex with the stimulatory antibody HL4E10 | Molecular insights into γδ T-cell costimulation by an anti-JAML
antibody
Petra Verdino1, Deborah A. Witherden2, M. Sharon Ferguson1, Adam L. Corper1, André
Schiefner1, Wendy L. Havran2, and Ian A. Wilson1,3,*
1Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines
Road, La Jolla, Cali... |
3MJA | Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to selenate, structure #2 | REPORT
Identification and characterization of anion binding
sites in RNA
JEFFREY S. KIEFT,1 ELAINE CHASE,2 DAVID A. COSTANTINO,1 and BARBARA L. GOLDEN2
1Howard Hughes Medical Institute and Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine,
Aurora, Colorado, 80045, USA
2Departm... |
3MJB | Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to sulfate | REPORT
Identification and characterization of anion binding
sites in RNA
JEFFREY S. KIEFT,1 ELAINE CHASE,2 DAVID A. COSTANTINO,1 and BARBARA L. GOLDEN2
1Howard Hughes Medical Institute and Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine,
Aurora, Colorado, 80045, USA
2Departm... |
3MJG | The structure of a platelet derived growth factor receptor complex | Structures of a platelet-derived growth factor/
propeptide complex and a platelet-derived
growth factor/receptor complex
Ann Hye-Ryong Shima,1, Heli Liua,1, Pamela J. Fociaa, Xiaoyan Chena, P. Charles Linb, and Xiaolin Hea,2
aDepartment of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinber... |
3MJH | Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1 | Structural basis for Rab GTPase recognition and
endosome tethering by the C2H2 zinc finger
of Early Endosomal Autoantigen 1 (EEA1)
Ashwini Mishra, Sudharshan Eathiraj, Silvia Corvera, and David G. Lambright1
Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachus... |
3MJK | Structure of a growth factor precursor | Structures of a platelet-derived growth factor/
propeptide complex and a platelet-derived
growth factor/receptor complex
Ann Hye-Ryong Shima,1, Heli Liua,1, Pamela J. Fociaa, Xiaoyan Chena, P. Charles Linb, and Xiaolin Hea,2
aDepartment of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinber... |
3MJR | Human dCK complex with Acyclic Nucleoside | The sugar ring of the nucleoside is required for productive
substrate positioning in the active site of human deoxycytidine
kinase (dCK): implications for the development of dCK-activated
acyclic guanine analogs
Saugata Hazra1, Manfred Konrad2, and Arnon Lavie1,*
1 Department of Biochemistry and Molecular Genetics, Uni... |
3MJZ | The crystal structure of native FG41 MSAD | Kinetic, Mutational, and Structural Analysis of Malonate
Semialdehyde Decarboxylase from Coryneform bacterium strain
FG41: Mechanistic Implications for the Decarboxylase and
Hydratase Activities
Youzhong Guo∥,§, Hector Serrano∥,§, Gerrit J. Poelarends‡, William H. Johnson Jr.∥, Marvin
L. Hackert⊥, and Christian P. Whit... |
3MK0 | Refinement of placental alkaline phosphatase complexed with nitrophenyl | structural communications
866
doi:10.1107/S1744309110019767
Acta Cryst. (2010). F66, 866–870
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Refined structures of placental alkaline phosphatase
show a consistent pattern of interactions at the
peripheral site
Bogusla... |
3MK1 | Refinement of placental alkaline phosphatase complexed with nitrophenyl | structural communications
866
doi:10.1107/S1744309110019767
Acta Cryst. (2010). F66, 866–870
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Refined structures of placental alkaline phosphatase
show a consistent pattern of interactions at the
peripheral site
Bogusla... |
3MK2 | Placental alkaline phosphatase complexed with Phe | structural communications
866
doi:10.1107/S1744309110019767
Acta Cryst. (2010). F66, 866–870
Acta Crystallographica Section F
Structural Biology
and Crystallization
Communications
ISSN 1744-3091
Refined structures of placental alkaline phosphatase
show a consistent pattern of interactions at the
peripheral site
Bogusla... |
3MK4 | X-Ray structure of human PEX3 in complex with a PEX19 derived peptide | Insights into Peroxisome Function from the Structure of PEX3
in Complex with a Soluble Fragment of PEX19*□
S
Received for publication,April 27, 2010, and in revised form, May 17, 2010 Published, JBC Papers in Press,June 16, 2010, DOI 10.1074/jbc.M110.138503
Friederike Schmidt‡1, Nora Treiber§1,2, Georg Zocher‡, Sasa Bj... |
3MK6 | Substrate and Inhibitor Binding to Pank | Modulation of Pantothenate Kinase 3 Activity by Small
Molecules that Interact with the Substrate/Allosteric Regulatory
Domain
Roberta Leonardi1, Yong-Mei Zhang1,4, Mi-Kyung Yun2, Ruobing Zhou1, Fu-Yue Zeng3,5,
Wenwei Lin3, Jimmy Cui3, Taosheng Chen3, Charles O. Rock1, Stephen W. White2, and
Suzanne Jackowski1,*
1Depart... |
3MK8 | The MCL-1 BH3 Helix is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer | The MCL-1 BH3 Helix is an Exclusive MCL-1 inhibitor and
Apoptosis Sensitizer
Michelle L. Stewart1,2, Emiko Fire3, Amy E. Keating3, and Loren D. Walensky1,2,*
1 Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children’s Hospital
Boston, Harvard Medical School, Boston, Massachusetts 02115
2 Program i... |
3MK9 | Stabilized Ricin Immunogen 1-33/44-198 | Introduction of a Disulfide Bond Leads to Stabilization and
Crystallization of a Ricin Immunogen§
Jaimee R. Compton†, Patricia M. Legler†, Benjamin V. Clingan, Mark A. Olson1, and Charles
B. Millard*
Department of Structural Biology, Walter Reed Army Institute of Research, Silver Spring, MD
20910
1Department of Cell Bi... |
3MKA | Crystal Structure of Mycobacterium Tuberculosis Proteasome with propetide and an T1A mutation at beta-subunit | Structural basis for the assembly and gate closure
mechanisms of the Mycobacterium tuberculosis
20S proteasome
Dongyang Li1,4, Hua Li1,4, Tao Wang1,
Hong Pan2, Gang Lin3 and Huilin Li1,2,*
1Department of Biology, Brookhaven National Laboratory, Upton,
NY, USA, 2Department of Biochemistry and Cell Biology, Stony Brook
U... |
3MKB | Crystal structure determination of Shortfin Mako (Isurus oxyrinchus) hemoglobin at 1.9 Angstrom resolution | diffraction structural biology
J. Synchrotron Rad. (2013). 20, 843–847
doi:10.1107/S0909049513021572
843
Journal of
Synchrotron
Radiation
ISSN 0909-0495
Received 9 May 2013
Accepted 2 August 2013
Structural studies of haemoglobin from pisces
species shortfin mako shark (Isurus oxyrinchus)
at 1.9 A˚ resolution
Pandian R... |
3MKE | SHV-1 beta-lactamase complex with LP06 | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 2011, p. 174–183
Vol. 55, No. 1
0066-4804/11/$12.00
doi:10.1128/AAC.00930-10
Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Novel Insights into the Mode of Inhibition of Class A SHV-1 -Lactamases
Revealed by Boronic Acid Transition State Inhibitors... |
3MKF | SHV-1 beta-lactamase complex with GB0301 | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 2011, p. 174–183
Vol. 55, No. 1
0066-4804/11/$12.00
doi:10.1128/AAC.00930-10
Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Novel Insights into the Mode of Inhibition of Class A SHV-1 -Lactamases
Revealed by Boronic Acid Transition State Inhibitors... |
3MKH | Podospora anserina Nitroalkane Oxidase | Identification of a Hypothetical Protein from Podospora anserina
as a Nitroalkane Oxidase†
José R. Tormos‡, Alexander B. Taylor‡, S. Colette Daubner§, P. John Hart‡,#, and Paul F.
Fitzpatrick‡,†,*
‡ Department of Biochemistry, University of Texas Health Science Center, San Antonio TX, 78229
§ Department of Biology, St.... |
3MKO | Crystal Structure of the Lymphocytic Choriomeningitis Virus Membrane Fusion Glycoprotein GP2 in its Postfusion Conformation | X-ray structure of the arenavirus glycoprotein
GP2 in its postfusion hairpin conformation
Sébastien Igoneta,b, Marie-Christine Vaneya,b, Clemens Von
einc, Gérard Bricognec, Enrico A. Sturad, Hans Hengartnere,
Bruno Eschlie, and Félix A. Reya,b,1
aDépartement de Virologie, Unité de Virologie Structurale, Institut Pasteu... |
3MKQ | Crystal structure of yeast alpha/betaprime-COP subcomplex of the COPI vesicular coat | Structure of Coatomer Cage Proteins and the Relationship among
COPI, COPII and Clathrin Vesicle Coats
Changwook Lee and Jonathan Goldberg
Howard Hughes Medical Institute and the Structural Biology Program, Memorial Sloan-Kettering
Cancer Center, 1275 York Avenue, New York, New York 10065
Summary
COPI-coated vesicles fo... |
3MKR | Crystal structure of yeast alpha/epsilon-COP subcomplex of the COPI vesicular coat | Structure of Coatomer Cage Proteins and the Relationship among
COPI, COPII and Clathrin Vesicle Coats
Changwook Lee and Jonathan Goldberg
Howard Hughes Medical Institute and the Structural Biology Program, Memorial Sloan-Kettering
Cancer Center, 1275 York Avenue, New York, New York 10065
Summary
COPI-coated vesicles fo... |
3MKS | Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2 | An allosteric inhibitor of substrate recognition by the SCFCdc4
ubiquitin ligase
Stephen Orlicky1, Xiaojing Tang1, Victor Neduva2, Nadine Elowe3, Eric Brown3, Frank
Sicheri1,*, and Mike Tyers1,2,*
1Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital,
Toronto, Canada M5G 1X5
2Wellcom... |
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