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[ ", the present study focused on the detection of the ongoing inflammatory changes in the bone and neighboring tissues directly affected by the destructive disease in pd patients . however , although how the inflammation develops in the gingival tissue of pd patients is largely described , little is known about the ...	chronic periodontitis is a multifactorial inflammatory disease that affects supporting structures of the teeth . although the gingival response is largely described , little is known about the immune changes in the alveolar bone and neighboring tissues that could indicate periodontal disease ( pd ) activity . then , in...
[ "now a days , its use is not limited to treat narcolepsy and other sleep wake disorders , but also in chronic fatigue syndrome , treatment resistant depression , attention deficit hyperactivity disorder and cocaine dependency.1 ) reportedly it has a much lower abuse potential but some have also suggested it to be h...	apart from sleep wake disorders , nowadays , modafinil is being prescribed for several psychiatric disorders including depression . despite being reported as to be having very low abuse potential , cases of modafinil dependence had come to the limelight . in this case report , we describe a 35 year old man with bipolar...
[ ", we aimed to determine the therapeutic effect of synbiotics ( combination of probiotics containing strains of l. casei , l. rhamnosus , s. thermophilus , b. breve , l. acidophilus , b. infantis , and fructooligo - saccharide as prebiotic ) on childhood constipation . children usually are treated with a combinatio...	objectiveconstipation is a common problem in children . there is some clinical evidence for the role of probiotics and prebiotics in the treatment of constipated children . this is the first study on the therapeutic effect of synbiotics ( combination of probiotics and prebiotic ) in treatment of childhood constipation....
[ "fourier transform infrared ( ft - ir ) was also applied to characterize the structure and purity of the compound . magnetic properties and hysteresis loop of the mnps were studied by vibrating sample magnetometer ( vsm ) . afterwards , we injected these particles intratumorally in mice bearing implanted melanoma c...	background : nowadays , magnetic nanoparticles ( mnps ) have received much attention because of their enormous potentials in many fields such as magnetic fluid hyperthermia ( mfh ) . the goal of hyperthermia is to increase the temperature of malignant cells to destroy them without any lethal effect on normal tissues . ...
[ ", we describe a case of angiosarcoma in which complete remission was archived with low dose docetaxel and bisphosphonate after the standard treatment of angiosarcoma . considerable evidence has implicated matrix metalloproteinases ( mmp ) in the degradation of the extracellular matrix ( ecm ) during the metastatic...	we describe a 78-year - old japanese patient with angiosarcoma on the scalp . interestingly , immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 ( mmp-9 ) . after conventional therapy for angiosarcoma with surgical treatment and radiation therapy , we intravenously administered ...
[ "it delivered bidirectional stimuli , and facilities for measuring various parameters of electrical dose had been incorporated in the device . with the demonstration of cognitive superiority and comparable efficacy of brief - pulse ect , the precision and flexibility of electrical parameters provided by this ect ma...	in 1993 , a device to administer brief - pulse electroconvulsive therapy was indigenously developed through collaboration between the national institution for quality and reliability and the national institute of mental health and neurosciences ( nimhans ) , bengaluru , karnataka , india . the additional feature of com...
[ "the many genetic studies performed in recent years showed that genes such as interleukin 23 receptor ( il23r ) and il12b and tumor necrosis factor alpha ( tnf ) are closely associated with psoriasis and related diseases such as rheumatoid arthritis , psoriatic arthritis , and crohn 's disease . human leukocyte ant...	psoriasis is a chronic skin disease in which genetics play a major role . although many genome - wide association studies have been performed in psoriasis , knowledge of the age at onset remains limited . therefore , we analyzed 173 single - nucleotide polymorphisms in genes associated with psoriasis and other autoimmu...
[ "a case showing sustained structural and functional responses 2 years after a single treatment with iluvien ( 0.2 g / day fluocinolone acetonide , fac ) despite suboptimal responses to ranibizumab .", "a 68-year - old female patient with diabetic macular oedema ( dme ) from type 2 diabetes mellitus was first diag...	importancea case showing sustained structural and functional responses 2 years after a single treatment with iluvien ( 0.2 g / day fluocinolone acetonide , fac ) despite suboptimal responses to ranibizumab.observationsa 68-year - old female patient with diabetic macular oedema ( dme ) from type 2 diabetes mellitus was ...
[ "we used molecular inversion probes to capture all exons and 5 base pairs of flanking intronic depdc5 sequence ; next - generation sequencing and data analysis were performed as described previously in 130 patients with epileptic spasms of unknown etiology . we included an additional novel depdc5 case , identified ...	objective : to assess the presence of depdc5 mutations in a cohort of patients with epileptic spasms.methods:we performed depdc5 resequencing in 130 patients with spasms , segregation analysis of variants of interest , and detailed clinical assessment of patients with possibly and likely pathogenic variants.results:we ...
[ "the correlation between the gray values obtained from cbct and the hus in ct images was evaluated and the effect of the type of tissue , tissue thickness , acquisition parameters and location was assessed in this regard . cone - beam computed tomography ( cbct ) has become a widely used imaging modality for pre - ...	objectives : bone quality and quantity assessment is one of the most important steps in implant treatment planning . different methods such as computed tomography ( ct ) and recently suggested cone beam computed tomography ( cbct ) with lower radiation dose and less time and cost are used for bone density assessment . ...
[ "finally , the accumulation of cadmium , copper , and nickel in cucumber roots was asseyed to estimate to what degree the efficiency of metal absorption may affect the h - atpase activity . moreover , the effect of cantharidin , a specific inhibitor of phosphatases , on the inhibitory action of metals on the h - at...	the effect of heavy metals on the modification of plasma membrane h+-atpase ( ec 3.6.3.14 ) activity in cucumber roots was studied . in plants stressed for 2 h with 10 m or 100 m cd , cu or ni the hydrolytic as well as the transporting activity of h+-atpase in the plasma membranes of root cells was decreased . transcri...
[ "we present recent studies that have using optogenetic and chemogenetic approaches to explore the function of astrocytes and gliotransmitters . although accumulating evidence suggests a coupling between various intracellular changes in astrocytes , such as intracellular calcium increase and gliotransmitter release ...	the brain consists of heterogeneous populations of neuronal and non - neuronal cells . the revelation of their connections and interactions is fundamental to understanding normal brain functions as well as abnormal changes in pathological conditions . optogenetics and chemogenetics have been developed to allow function...
[ "the online version of this article ( doi:10.1007/s10953 - 014 - 0276-y ) contains supplementary material , which is available to authorized users .", "the ternary systems { il ( 1 ) + thiophene , or benzothiophene ( 2 ) + heptane ( 3 ) } were investigated at t = 308.15 k and p = 101.33 kpa . the experi...	in this work , the desulfurization ability of alkyl - piperidinium - based and phosphonium - based ionic liquids ( ils ) for ( thiophene or benzothiophene + heptane ) mixtures are studied . with this aim , ternary liquid liquid phase equilibrium data ( lle ) have been obtained for mixtures of { il ( 1 ) + thiophene...
[ "higher carriage rates are seen in diabetics , intravenous drug users ( ivdu ) , hiv and dialysis patients . all infective foci must be identified and removed as soon as possible ; however , foci are not always obvious and long - term antimicrobial therapy might be necessary . all patients with s. aureus bacteremia...	methicillin - sensitive staphylococcus aureus ( mssa ) meningitis is a rare disease when not related to neurosurgery : there are only few reported cases in the literature to date . we describe a case that highlights not only meningeal but also diffuse and rapidly progressive systemic involvement with multi - organ fail...
[ "the ultimate aim of the present study is , therefore , to test the efficacy of abs nanohemostat formed by combination of a self - assembling pa molecule and ankaferd hemostat for controlling surgical bleeding due to renal injury during partial nephrectomy ( pn ) and to compare its hemostatic effects to the traditi...	purpose . using the classical ankaferd blood stopper ( abs ) solution to create active hemostasis during partial nephrectomy ( pn ) may not be so effective due to insufficient contact surface between the abs hemostatic liquid agent and the bleeding area . in order to broaden the contact surface , we generated a chimeri...
[ "therefore , this study evaluated changes in the physicopsychological functions of elderly \n women with a fear of falling in negotiating obstacles such as a doorstep ( 5.2 cm ) of a \n bathroom , where falling occurs frequently , through a performance - oriented mobility \n assessment ( poma ) in order to underst...	[ purpose ] the aim of the present study was to investigate the effects of core stability exercise ( cse ) on the physical and psychological functions of elderly women while negotiating general obstacles . [ subjects and methods ] after allocating 10 elderly women each to the core stability training group and the...
[ "we present two cases of ica thrombosis with concomitant middle cerebral artery ( mca ) thrombosis secondary to the thrombus present in the ica lumen , in which the postmortem examination , the medical records regarding hospitalization and records of investigation indicated trauma as the cause of thrombosis . neck ...	the following manuscript presents two cases of ischemic stroke secondary to traumatic internal carotid artery thrombosis with concomitant middle cerebral artery thrombosis occurring very rarely in the medico - legal practice . penetrating neck trauma due to an occupational accident and multiple head and neck trauma sec...
[ "erythromelalgia ( em ) is a rare disease characterized by painful swelling and erythema on the extremities [ 1 , 2 , 3 ] . , we describe a case of adult - onset em successfully controlled with steroid pulse and pregabalin . in contrast , em with thrombocythemia is usually treated with aspirin , since the burning p...	adult - onset erythromelalgia ( em ) is a rare disease characterized by episodic bouts of burning pain and erythema for which the optimal therapy is unclear . in this report , we describe a 68-year - old japanese woman with adult - onset em . intravenous administration of methylprednisolone sodium succinate 1,000 mg / ...
[ "the \n aim of the study was to investigate the effect of liaison nurse on patient outcomes after \n icu discharge . discharging patient from intensive care unit ( icu ) is a difficult and complex process \n because icu nurses need to provide a lot of critical information to patients and delegate \n many heavy re...	introduction : recent studies suggest that liaison nurse intervention might be effective to solve the gap between intensive care unit and wards , but little studies are known about the effect of this intervention . the aim of this study was to investigate the effect of liaison nurse service on patient outcomes af...
[ "we believe that what is needed , in addition to developments already highlighted , is to implement recommendation by de cock et al . that hiv and aids be addressed as a disease of the family and the community and that hiv interventions be integrated across the lifecycle of women , families and children . , the cri...	virtual prevention of hiv transmission from parents to children is possible . this is cause for hope and renewed energy for prevention in general . the global plan is the most concerted and ambitious plan to date to protect children and to promote their care . but the inspiring and much appreciated global targets can n...
[ "", ", we explore the genome - wide response of worker bee brains to experimental infection . honey bees are also infected by several rna viruses , and one of the most prevalent is the positive single strand rna virus , black queen cell virus ( bqcv ) . in a previous study , we showed that bqcv and n. ceranae int...	regulation of gene expression in the brain plays an important role in behavioral plasticity and decision making in response to external stimuli . however , both can be severely affected by environmental factors , such as parasites and pathogens . in honey bees , the emergence and re - emergence of pathogens and potenti...
[ "the output of the oligowalk server is a table of sirna candidates , showing the sirna sequences and the probabilities of being efficient ( having silencing efficacy larger than 70% ) . the svm classification model used in the server has been proven to be able to predict efficient sirna ( greater than 70% inhibitio...	given an mrna sequence as input , the oligowalk web server generates a list of small interfering rna ( sirna ) candidate sequences , ranked by the probability of being efficient sirna ( silencing efficacy greater than 70% ) . to accomplish this , the server predicts the free energy changes of the hybridization of an si...
[ "no studies have been conducted on the changes in muscles related to stroke patients \n stability and balance after hippotherapy . in this study , the improvement in stroke patients \n trunk control and changes in abdominal muscle thicknesses after horse riding simulation \n training were examined . therefore , imp...	[ purpose ] the purpose of this study was to assess the effects of horse riding simulation training on changes in balance ability and abdominal muscle thicknesses of stroke patients . [ subjects ] thirty stroke patients with hemiplegia were recruited , and they were randomly assigned to a control or experimental ...
[ ", hydrogen sulfide ( h2s ) has captured the interest of scientists because of its significant role in different systems of the body . a number of gases are produced endogenously in humans and have roles in the pathology of various diseases . among these gases , nitric oxide ( no ) and carbon monoxide ( co ) have v...	in the family of gas transmitters , hydrogen sulfide ( h2s ) is yet not adequately researched . known for its rotten egg smell and adverse effects on the brain , lungs , and kidneys for more than 300 years , the vasorelaxant effects of h2s on blood vessel was first observed in 1997 . since then , research continued to ...
[ "we report a pregnant woman who presented with signs and symptoms of acute mi and whose ecg findings and troponin 1 level were compatible with mi , leading to the final diagnosis of prinzmetal s angina . the risk of myocardial infarction ( mi ) in pregnancy is reported from one per 37,500 to 6.2 per 100,000 deliver...	acute myocardial infarction ( mi ) during pregnancy is rare and mi due to prinzmetal s angina is much rarer . we present a 35-year - old , obese , multigravida , and pre - eclamptic woman , who developed acute anterior wall mi at the 30th week of gestation . on coronary angiography , the second obtuse marginal branch w...
[ "moderate or severe mitral regurgitation ( mr ) is the most frequent valve disease in the usa and the second most common form of valvular heart disease needing surgery in europe . degenerative mitral valve disease ( mvd ) is the leading cause of organic mr in western countries . recent guidelines stated that real -...	degenerative mitral valve disease ( mvd ) is the leading cause of organic mitral regurgitation ( mr ) , one of the most common valvular heart disease in western countries . substantial progresses in the surgical treatment of degenerative mvd have improved life expectancy of patients with significant mr . however , prog...
[ "surgical resections such as unilateral temporal lobectomy and amygdalo - hippo - campectomy have an established place in the management of carefully selected patients with refractory localisation - related epilepsy . adverse cognitive sequelae of epilepsy surgery have been well - recognised since the seminal repor...	we describe a patient who developed significant cognitive decline with profound amnesia following non - dominant temporal lobectomy for refractory seizures , in whom the original suspicion of structural pathology was revised following the discovery of clinical and neuropathological markers of inflammation , neuropsycho...
[ "however , cardiac metastasis is diagnosed in less than 1% of patients with malignant melanoma because less than 10% of these patients present with cardiac symptoms.1 - 3 ) identification of cardiac metastasis from melanoma usually means that the patient is suffering systemic metastasis . unlike typical cardiac met...	malignant melanoma has a very high propensity to metastasize to the heart . however , melanoma may sometimes present as a metastatic lesion in the absence of a primary lesion , which are called melanomas of unknown primary origin . we report a case in which a patient presented with a metastatic maligant melanoma in the...
[ "calcium is released from bone under the effect of vitamin d - pth system to maintain its homeostasis . this raises logical question do all subjects with vdd have clinical disease according to this definition ? the main physiological function of vitamin d is maintenance of calcium homeostasis by its effect on cal...	the main physiological function of vitamin d is maintenance of calcium homeostasis by its effect on calcium absorption , and bone health in association with parathyroid gland . vitamin d deficiency ( vdd ) is defined as serum 25-hydroxy vitamin d ( 25ohd ) levels < 20 ng / ml . do all subjects with vdd have clinical di...
[ "the penn diabetes heart study ( pdhs ) is an ongoing , cross - sectional study of individuals with type 2 diabetes ( aged 3575 years ) without clinical evidence of cvd ( myocardial infarction , coronary revascularization or angiographic disease , positive stress test , clinical peripheral arterial disease or perip...	objectivefetuin - a is an inhibitor of vascular calcification and a mediator of insulin resistance . this study evaluated the association of plasma fetuin - a and peripheral arterial disease ( pad).research design and methodsa total of 738 individuals with type 2 diabetes ( mean age 58.7 years , 37.1% female ) without ...
[ "collecting duct carcinoma ( cdc ) of the kidney is an unusual variant of renal cell carcinoma ( rcc ) , accountings for less than 1% of all renal cancers . the aim of this study is to conduct an investigation of the clinicopathologic findings of cdc and to determine their correlation with the disease status and pr...	purposecollecting duct carcinoma ( cdc ) of the kidney is an aggressive disease with a poor prognosis , accountings for less than 1% of all renal cancers . to date , no standard therapy for cdc has been established . the aim of this study is an investigation of clinicopathologic findings of cdc and correlation of the d...
[ "after approval by the institutional review board of the federal university of so paulo , brazil , 500 patients with dm from the diabetic foot outpatient clinic of orthopaedic department of the federal university of so paulo were enrolled in a prospective study to evaluate the results of minimally invasive surgery ...	complications of diabetes mellitus constitute the most common indications for hospitalization and non - traumatic amputations in the usa . the most important risk factors for the development of diabetic foot ulcerations include the presence of peripheral neuropathy , vasculopathy , limited joint mobility , and pre - ex...
[ "2 ) , and we identified the \" lung point \" sign , which can be used to diagnose pneumothorax . also , chest radiography indicated a < 30% collapse of the right lung ( fig . auscultation of the right lung improved , as well as the appearance of lung sliding sign and the disappearance of the lung point sign in who...	pneumothorax during general anesthesia is more difficult to diagnose compared with that of non - anesthetized patient . furthermore , the early diagnosis of pneumothorax is to some extent difficult due to co2-pneumoperitoneum during laparoscopic surgery . the use of ultrasonography to diagnose pneumothorax has increase...
[ "therefore , to prevent knee \n injuries in females , improved muscle balance around the knee during dynamic motions such as \n landing and balanced strengthening of lower limb muscles are necessary . kim et al.1 found kinematic differences in landing \n motions between male and female college students and reported...	[ purpose ] this study investigated the effect of the single - leg , lateral oblique , decline squat exercise on sacroiliac joint pain with knee pain . [ subjects and methods ] a 39-year - old female had severe pain in the right medial buttock and right anterior knee . this study assessed the anterior pelvic tilt a...
[ "the objective of the present study was to examine whether social isolation in growing male rats affected 24-h variations of activity of the hypophysial gonadal axis . we measured the daily pattern of plasma prolactin , luteinizing hormone ( lh ) , follicle - stimulating hormone ( fsh ) and testosterone levels at 6...	backgroundthis work analyzes the effect of social isolation ( a mild stressor ) on the 24-h variation of pituitary - testicular function in young wistar rats , assessed by measuring circulating levels of prolactin , fsh , lh and testosterone.methodsanimals were either individually caged or kept in groups ( 45 animals p...
[ "we report herein on the clinical outcome of bilateral surgical excisions of cnv in a pic case which failed anti - vegf treatment . electron microscopic evaluation was performed on the excised specimens in an attempt to elucidate the pathogenesis of the condition and the possible mechanisms of treatment failure . p...	purposethis study aims to describe surgical management results and the pathologic features of choroidal neovascularization ( cnv ) secondary to punctate inner choroidopathy ( pic ) following anti - vascular endothelial growth factor treatment.designthis study is a case report on the surgical management and ultrastructu...
[ "the present study , therefore , carried out a systematic review of the relevant studies and performed a meta - analysis of all related parameters for the sake of evaluating the efficacy of cort therapy observed in studies with controlled designs . moreover , evidence regarding the role of corticosteroids in improv...	backgroundhemolysis , elevated liver enzymes , and low platelet count ( hellp ) syndrome is a severe condition of pregnancy that is associated with significant morbidity and mortality . corticoteroid ( cort ) therapy is common in the management of hellp syndrome . this study evaluates the efficacy of cort therapy to pa...
[ "during the last few years , dual - source high - pitch imaging has become increasingly important in the daily routine of radiology departments . in dual - source computed tomography ( ct ) imaging two this makes high - pitch imaging the technique of choice , especially when regions of the body that are normally s...	objectives : the aim of our study was to find out how much energy is applicable in second - generation dual source high - pitch computed tomography ( ct ) in imaging of the abdomen.materials and methods : we examined an upper abdominal phantom using a somatom definition flash ct - scanner ( siemens , forchheim , german...
[ "the cancers associated with different genetic syndromes occur at different ages , they may differ with respect to tumour characteristics , they have different prognosis , and they respond differently to prophylactic and treatment modalities . following the clinical genetic work - up to provide health care to a wom...	inherited breast - ovarian cancer was described in 1866 . the underlying genetic defects in brca1/2 were demonstrated 128 years later . we now have 10 years of experience with genetic testing in brca kindreds . the majority of breast cancer kindreds ( familial breast cancer ) do not demonstrate ovarian cancer and are n...
[ "the past 15 years have seen major advances in our understanding of severity assessment in community - acquired pneumonia ( cap ) . several recent studies , including the study by renaud and colleagues , have challenged us to re - evaluate how we consider severe cap , a concept for which there is still no universal...	the past 15 years have seen major advances in our understanding of severity assessment in community - acquired pneumonia ( cap ) . prognostic tools have been promoted to guide all major management decisions in cap , including admission to the critical care unit . several recent studies , including the study by renaud a...
[ "correlation of this expression with intensity of early neurodegeneration detected in the brain during the et-1 induced model of stroke was also analyzed . additionally , no breakdown in the blood - brain barrier was detected in the white and grey matter . in this study expression of several chemokines including ...	neurodegeneration is a hallmark of most of the central nervous system ( cns ) disorders including stroke . recently inflammation has been implicated in pathogenesis of neurodegeneration and neurodegenerative diseases . the aim of this study was analysis of expression of several inflammatory markers and its correlation ...
[ "some authors have even termed midurethral sling surgery as the new gold - standard for sui . with the available midurethral slings , the trocar has to be passed blindly either from above ( suprapubically ) or below ( transvaginally ) , which increases the chances of injury to the pelvic organs and blood vessels . ...	objectives : we report our experience of pure stress urinary incontinence ( sui ) treated by midurethral synthetic sling placement by modified raz technique.materials and methods : fifty - three patients with pure sui operated at our institute between june 2003 and december 2008 were included in this study . midurethra...
[ "however , despite the half - life of 15 hours , the wakefulness promoting effect of modafinil is found to be ill - sustained in the last one third of night shift hours . this was a randomized , comparative , double - blind , and multicentric study comparing the effects of modafinil 200 mg with armodafinil 150 mg...	aim . to compare the efficacy and safety of armodafinil , the r - enantiomer of modafinil , with modafinil in patients of shift work sleep disorder ( swsd ) . material and methods . this was a 12-week , randomized , comparative , double - blind , multicentric , parallel - group study in 211 patients of swsd , receiving...
[ "patients with hepatic disease , especially those with severe hepatic disease , may be more susceptible to the potential toxicities of the amide - type local anesthetics . when administered in recommended doses and concentrations , bupivacaine hydrochloride does not ordinarily produce irritation or tissue damage an...	one of the most important goal in minor surgical procedures is to achieve proper and sufficient anesthesia and analgesia preoperatively , intraoperatively and in the immediate postoperative period . several local anesthetic agents have been cited in the literature and studied . bupivacaine is one of the most common lon...
[ "in addition , we characterized the phenotypes of sea lion - derived coccidian protozoa in both a mouse model of pathogenesis and in mammalian cell culture . , we examined the diversity of coccidian parasites shed by hospitalized and free - ranging sea lions at coastal haul - out locations in central california . c...	tissue - cyst forming coccidia in the family sarcocystidae are etiologic agents of protozoal encephalitis in marine mammals including the federally listed southern sea otter ( enhydra lutris ) . california sea lions ( zalophus californianus ) , whose coastal habitat overlaps with sea otters , are definitive hosts for c...
[ "both native siderophores and synthetic siderophore mimics \n have been evaluated as platforms for therapeutic development . in the clinic , the native siderophore desferrioxamine \n b is used for iron - chelation therapy in patients with iron overload . \n , we present \n the syntheses and characterization of \n s...	the design , synthesis , and characterization of enterobactin antibiotic conjugates , hereafter ent - amp / amx , where the -lactam antibiotics ampicillin ( amp ) and amoxicillin ( amx ) are linked to a monofunctionalized enterobactin scaffold via a stable poly(ethylene glycol ) linker are reported . under co...
[ "we describe a mild case of adult onset hd early in the disease course along with mri and diffusion tensor imaging ( dti ) features . increased fractional anisotropy ( fa ) of striatum huntington 's disease ( hd ) is a dominantly inherited neurodegenerative disease caused by mutations in the it-15 gene on chromosom...	huntington 's disease ( hd ) is a dominantly inherited neurodegenerative disease best known for chorea . the disorder includes numerous other clinical features including mood disorder , eye movement abnormalities , cognitive disturbance , pendular knee reflexes , motor impersistence , and postural instability . we desc...
[ ", we report on a patient with ich who showed a change in the origin of an injured cst from the premotor cortex ( pmc ) to the primary motor cortex ( m1 ) . because motor weakness is one of the most serious disabling sequelae of stroke , so it is important to elucidate the motor recovery mechanism for successful re...	many studies have attempted to elucidate the motor recovery mechanism of stroke , but the majority of these studies focus on cerebral infarct and relatively little is known about the motor recovery mechanism of intracerebral hemorrhage . in this study , we report on a patient with intracerebral hemorrhage who displayed...
[ "however , due to the nature of the disease , many patients will progress through guideline - recommended standard regimens while maintaining a good performance status . colorectal cancer ( crc ) is one of most common cancers and leading causes of mortality in the usa , accounting for approximately 136,000 new case...	regorafenib , an oral multikinase inhibitor , was approved in september 2012 by the us food and drug administration for the treatment of patients with metastatic colorectal cancer . since this time , however , few case reports outlining real - world usage have been published in the literature . here , we detail the cli...
[ "this article presents an innovative approach that consists of a criss - cross trans - nipple incision to retrieve the fibro - glandular tissues following liposuction method for excellent outcomes . there had to be a solution for the smooth delivery of fibro glandular tissues without added scarring . the trans - ni...	context : the established techniques that have been used to treat gynaecomastia are said to have relatively less patient satisfaction rate as they leave some visible scars or mild elevation over the nipple areola complex , resulting in aesthetically unsatisfactory results . even the slightest elevation or smallest scar...
[ "the natural history of acute myeloid leukamia ( aml ) is typically unfavorable with rapid progression leading to death in the absence of specific therapy . for the first time , we report the cases of three patients with similar genetic characteristics diagnosed with aml m5 according to the fab classification , who...	key clinical messagepatients with npm1-mutated aml m5 who develop spontaneous remission ( sr ) after antibiotic therapy at diagnosis seem to form a favorable prognosis and chemo sensitive subtype . we report three cases of aml m5 patients with the same genotype that experienced transient sr and are now leukemia free af...
[ "therefore , in this study involving nationally representative samples of oncologists , we sought to investigate perceived difficulties with regard to rare cancer care and potential solutions endorsed by oncologists . rare cancers are not rare at all . despite the relatively low incidence of each type of cancer , r...	purposein response to the challenges and difficulties imposed by rare cancers , multi - stakeholder initiatives dedicated to improving rare cancer care was launched , and several recommendations were made by professional societies . however , these primarily reflect the view of the advocates and supporters , and may no...
[ "the purpose of the present study was to determine the relationship between basic physical \n fitness and pulmonary function in healthy korean school students to enable us to present an \n alternative method for improving their pulmonary function . the present study is to our knowledge the \n first to investigate t...	[ purpose ] the purpose of the present study was to determine whether there was a correlation between basic physical fitness and pulmonary function in korean school students , to present an alternative method for improving their pulmonary function . [ subjects and methods ] two hundred forty healthy students aged 6...
[ ", we developed a strategy , which makes use of the site - specific recombination system cre / loxp . by combining gene trap mutagenesis with site - specific recombination we employed this strategy to isolate genes induced in hematopoietic cells ( fdcp1 ) undergoing apoptosis by growth factor withdrawal . analysis ...	backgroundthe existence of a constitutively expressed machinery for death in individual cells has led to the notion that survival factors repress this machinery and , if such factors are unavailable , cells die by default . in many cells , however , mrna and protein synthesis inhibitors induce apoptosis , suggesting th...
[ ", we summarize the available data for noise - induced damage and repair around ihc sgn synapses and discuss the evidence for the contributions of cochlear malfunction and central plasticity to nihhl . noise - induced hidden hearing loss ( nihhl ) refers to any functional impairment seen in subjects with noise exp...	recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift ( pts ) can cause considerable damage around the synapses between inner hair cells ( ihcs ) and type - i afferent auditory nerve fibers ( anfs ) . disruption of these synapses not only disables the innervated ...
[ "we hereby report a closed total talar dislocation in a 25 year old male without an associated fracture around ankle . total talar dislocations are uncommon injuries and usually seen following high velocity injuries . total talar dislocations", "a 25 year old male presented to orthopaedic causality with injury to...	introduction : total talar dislocations are uncommon injuries and usually seen following high velocity injuries . total talar dislocations ( missing talus ) without fractures around the ankle are extremely rare . there are no consensuses on the best treatment of such injuries . to best of our knowledge very few cases h...
[ "therefore , the aim of this review was to assess the evidence for the \n effectiveness of yoga exercises in the management of primary headaches . evidence for the \n efficacy of yoga exercise for a number of conditions is emerging . yoga has been reported \n as a safe and cost - effective intervention for managing...	[ purpose ] to assess the evidence for the effectiveness of yoga exercises in the management of headaches . [ subjects and methods ] a search was conducted of six electronic databases to identify randomized controlled trials ( rcts ) reporting the effects of yogic intervention on headaches published in any langua...
[ "therefore , this study is focused on the genetic identification of staphylococcal exotoxins , sccmec types , and genetic relatedness by pulsed - field gel electrophoresis ( pfge ) of the sig isolates in korea . increased identification of methicillin - resistant sig ( mrsig ) isolates has emphasized the importance...	the staphylococcus ( s. ) intermedius group ( sig ) has been a main research subject in recent years . s. pseudintermedius causes pyoderma and otitis in companion animals as well as foodborne diseases . to prevent sig - associated infection and disease outbreaks , identification of both staphylococcal exotoxins and sta...
[ "therefore , we have conducted a research to determine the frequency of sexual activity , satisfaction and sexual dysfunction among postmenopausal women . no information exists on sexual functioning of postmenopausal women who are living in amol , a city in iran . increasing life expectancy has been accompanied by ...	background : sexual activity is an important part of the human being 's life but this instinct could be influenced by some factors such as diseases , drug using , aging , and menopause . but information about that is limited.aim:the aim of this study is to determine the status of sexual activity among married menopausa...
[ "the tubularized incised plate urethroplasty ( tipu ) repair is the procedure of choice for distal and mid - shaft hypospadias and is increasingly being used for proximal hypospadias and redo repairs . we evaluated the efficacy of spongioplasty alone after mobilization of corpus spongiosum in prevention of urethral...	introduction : additional cover after neourethra formation to decrease the fistula rate , has been described using the dartos , tunica , denuded skin and corpus spongiosum . the use of corpus spongiosum alone to cover the neourethra is infrequent . the objective of this study was to evaluate the efficacy of spongioplas...
[ "therefore , this study was undertaken in order to evaluate the presence of pms and pmdd and find their correlation with depression in a female population primarily comprising nursing students and staff in a rural setting . premenstrual syndrome ( pms ) is a common disorder of young and middle - aged women , charac...	background : premenstrual syndrome ( pms ) , premenstrual dysphoric disorder ( pmdd ) and depressive disorder are fairly common ; symptoms do overlap , often under - identified and under - emphasized , particularly in rural india.objective:the objective was to assess the occurrence of pms and pmdd in a sample of studen...
[ "the following case presentation deals with wt of the left parotid gland and highlights its clinicopathologic concepts along with its therapeutic management . this is a curious benign neoplasm with its intimidating histological name , papillary cyst adenoma lymphomatosum . benign neoplasms of the salivary glands ar...	warthin 's tumor undoubtedly is the most frequent monomorphic adenoma of the major salivary glands . clinically , it appears as a slow - growing tumor often fluctuant on palpation due to its cystic nature . the treatment of choice is complete excision with wide tumor - free margins . this article highlights a case of w...
[ "patients with diabetes are at increased risk of morbidity and mortality from cardiovascular disease ( cvd ) compared to normoglycemic controls.1 several additional factors may be associated with this increased risk , including persistent hyperglycemia , untreated hypertension , and dyslipidemia characterized by ra...	purposethis paper reports the results of an audit that assessed the prevalence of residual hypertriglyceridemia and the potential need for intensified management among patients with statin - treated type 2 diabetes mellitus ( t2 dm ) in primary care in the uk.patients and methodsa cross - sectional , observational , sy...
[ "approximately 95% occur in the neck and axilla , while the remaining 5% are found in the chest and abdomen . this case report documents a lymphangioma of the small bowel mesentery , incidentally discovered on pelvic ultrasound and initially thought to represent a complex cystic adnexal mass . lymphangiomas of the ...	lymphangiomas are benign lesions of mesenchymal origin . although more commonly encountered in the head and neck , intra - abdominal lymphangiomas are a rare entity that typically present as multiloculated intra - abdominal cystic lesions that are often incidentally discovered on imaging . this case report discusses su...
[ "this study reports that the addition of pectinase and cellulase alone or in mixtures enhanced the virulence of f. compactum on broomrape . , pectinolytic and cellulolytic enzymes have been used to enhance the virulence of f. compactum on tomato plants infested with broomrape . a series of experiments were conduc...	the use of enzyme could facilitate pathogen penetration into plant host . here the combination of cellulase and pectinase was ascertained on the pathogenicity of f. compactum ( 1.4 106 propagules ml1 ) on broomrape tubercles . f. compactum alone infected all the inoculated tubercles but did not kill any significant...
[ "isotopic signatures of environmental plutonium are generally used to assess the origin of the material . while decay counting is restricted to pu , pu , and pu the short lived nuclide pu ( t1/2 = 5 h ) decays in a reactor before pu is produced , which results in cm being the isotope of mass 244 produced in a re...	vera , the vienna environmental research accelerator , is especially equipped for the measurement of actinides , and performs a growing number of measurements on environmental samples . while ams is not the optimum method for each particular plutonium isotope , the possibility to measure 239pu , 240pu , 241pu , 242pu a...
[ "the aim of this study was to study the effects of home bleaching on the hardness and surface morphology of a universal nanocomposite , an anterior nanocomposite , and a nanohybrid composite . furthermore , a study was done to evaluate the effects of bleaching on toothbrush abrasion in three types of composites . t...	objective : home bleaching agents may not be safe for composite resins . the purpose of this study was to evaluate the effects of 10 and 20% opalescence pf home bleaching agents on the surface roughness and hardness of universal nanocomposite ( filtek z350 ) , anterior nanocomposite ( kelfil ) , and nanohybrid composit...
[ "penile squamous cell carcinoma ( pscc ) , the predominant histological type ( > 95% ) of penile cancer , is a relatively rare malignant tumor in western countries and japan . we report a case of a pscc with advanced lymph node metastasis treated with combination therapy consisting of taxane - based chemotherapy , ...	abstractpenile squamous cell carcinoma ( pscc ) is a rare disease , making it difficult to establish a standard of care , particularly in the advanced stage . we report a case of pscc with advanced lymph node metastasis treated with multimodal therapy consisting of combination chemotherapy , irradiation , and chemosurg...
[ "the aim of our study was to investigate if pregnant hiv - positive women get referred for special prenatal ultrasound screening services in our tertiary referral center , but also if and at what point the prenatal ultrasonography is performed . pregnant hiv - positive women usually have a combined antenatal care i...	objective . to assess the prevalence of prenatal screening and of adverse outcome in high - risk pregnancies due to maternal hiv infection . study design . the prevalence of prenatal screening in 330 pregnancies of hiv - positive women attending the department for prenatal screening and/or during labour between january...
[ "thus , the goal of this study was to estimate the prevalence of diabetes and its associated risk factors in adults of brasilia , brazil . studies have concluded that a western dietary pattern , sedentary lifestyle , and genetic factors play a central role in diabetes development . the city has the highest human de...	aim . the aim of this study was to estimate the prevalence of diabetes and its associated risk factors in adults from brasilia , brazil . methods . the present cross - sectional population - based study consisted of interviews with individuals aged 1865 years . participants were selected through two - stage probability...
[ "natural killer t ( nkt ) cells are innate - like lymphocytes typified by coexpression of receptors characteristic of natural killer and conventional t cells . as such , murine nkt cells generally bear ly49 receptors , nkg2 family of receptors , cd94 , and nk1.1 ( the latter only being expressed in specific strains...	natural killer t ( nkt ) cells are innate - like lymphocytes that were first described in the late 1980s . since their initial description , numerous studies have collectively shed light on their development and effector function . these studies have highlighted the unique requirements for the activation of these lymph...
[ "as a service to our authors and readers , this journal provides supporting information supplied by the authors . technical support issues arising from supporting information ( other than missing files ) should be addressed to the authors . such materials are peer reviewed and may be reorganized for online delivery...	abstractthe kinetics of formation of the valence tautomers ( tpfc)mniv(ola)]n+ [ where la = znii , caii , sciii , ybiii , b(c6f5)3 , and trifluoroacetic acid ( tfa ) ; tpfc=5,10,15tris(pentafluorophenyl ) corrole ] from ( tpfc)mnv(o ) were followed by uv / vis spectroscopy , giving secondorder rate constants ranging ov...
[ "we report , here , important learning from a small number of patients who completed prototype testing of this tool . the patient - reported outcomes measurement information system ( promis ) survey instruments may be appropriate for this purpose , but promis surveys have been validated only in population studies.1...	introduction : improving symptoms for patients with chronic illness is difficult due to poor recall and imprecise assessments of therapeutic response to inform treatment decisions . daily variation in symptoms may obscure subtle improvement or lead to erroneous associations between symptom changes and alteration in med...
[ "contact endoscopy and its efficacy in head and neck oncology , advantages , limitations , and future potential diagnostic utility will be briefly reviewed in this article . the vast majority of cancers in the oral cavity and in the head and neck are squamous cell carcinomas ( sccs ) . contact endoscopy is another ...	background . there are a variety of described noninvasive optical detection techniques for evaluation of head and neck mucosal lesions . contact endoscopy is a promising method of in vivo microscopic examination whereby a rigid telescope is placed on a previously dye - stained mucosa allowing evaluation of the superfic...
[ "the sts was the first professional organization to seek approval for its measures from the national quality forum ( nqf ) , a multi - stakeholder health policy organization head - quartered in washington , dc . in this manner , the sts has gained a positive reputation with the government and with health policy org...	the jcvsd ( japan cardiovascular surgery database ) was organized in 2000 to improve the quality of cardiovascular surgery in japan . web - based data harvesting on adult cardiac surgery was started ( japan adult cardiovascular surgery database , jacvsd ) in 2001 , and on congenital heart surgery ( japan congenital car...
[ "one of the most interesting approaches to nausea adopted by traditional chinese medicine and , in particular , by acupuncture is the stimulation of the acupoint pc6 neiguan . migraine is a disabling neurological disorder considered by the world health organization as the 19th leading cause of all years lived with ...	migraine is a disabling neurological disorder , aggravated by accompanying symptomatology , such as nausea . one of the most interesting approaches to nausea adopted by traditional chinese medicine is the stimulation of the acupoint pc6 neiguan . actually there are no studies in medical literature as to the efficacy of...
[ "my experience in state government has been that after natural or manmade point - source disasters , a governor reflexively turns to the office of emergency management , the department of public safety ( or homeland security ) , or the national guard for advice and counsel . it is essential , therefore , to establi...	this article proposes and discusses legal and administrative preparations for a bioterrorist attack . to perform the duties expected of public health agencies during a disease outbreak caused by bioterrorism , an agency must have a sufficient number of employees and providers at work and a good communications system be...
[ "marginal zone lymphoma of malt is , apart from diffuse large b - cell lymphoma , the most frequent type of lymphoma that occurs in the stomach . the name of mucosa - associated lymphoid tissue ( malt ) lymphoma was first established in 1983 by isaacson and du . from the beginning , it was adopted well and is still...	nowadays , it is believed that the main role in the development of gastric mucosa - associated lymphoid tissue ( malt ) lymphoma plays helicobacter pylori infection . this world - wide distributed bacteria is in charge of most cases of not only upper gastrointestinal tract disorders but also some of extragastric proble...
[ "airprom : airway disease , predicting outcomes through patient specific computational modeling ( fp7 ) ; bioshare - eu : biobank standardization and harmonization for research excellence in the european union ( fp7 ) ; ict : information communication technology ; medall : mechanisms of the development of allergy (...	we propose an innovative , integrated , cost - effective health system to combat major non - communicable diseases ( ncds ) , including cardiovascular , chronic respiratory , metabolic , rheumatologic and neurologic disorders and cancers , which together are the predominant health problem of the 21st century . this pro...
[ "the purpose of this study was to determine whether postmenopausal current ht users had significantly different iad than those who were former users of ht in the women on the move through activity and nutrition ( woman ) randomized trial . recent attention to the role of the adventitia in vascular remodeling has in...	arterial diameter is an underutilized indicator of vascular health . we hypothesized that interadventitial and lumen diameter of the common carotid artery would be better indicators of vascular health than carotid plaque or intima media thickness ( imt ) . participants were 491 overweight or obese , postmenopausal wome...
[ "several centers have been recently established where urologists partner with radiation oncologists acquire ownership interest in intensity - modulated radiation therapy ( imrt ) equipment and provide integrated prostate cancer care . although not yet validated in the literature , this may allow for improved qualit...	objective . as recent participants in an integrated prostate cancer ( pca ) care center , we sought to evaluate whether financial investment in an intensity - modulated radiation therapy ( imrt ) center resulted in an increased utilization of radiation therapy in our patients with newly diagnosed pca . materials & meth...
[ "common skeletal manifestations of nf-1 include spinal deformities , congenital tibial dysplasia ( congenital bowing and pseudarthrosis ) , sphenoidal dysplasia and cystic lesions in bones . pathological fracture of the acetabulum with anterior dislocation of hip secondary to osseous involvement of the acetabulum ,...	skeletal neurofibromatosis ( nf ) commonly manifests as scoliosis and tibial dysplasias . nf affecting the pelvic girdle is extremely rare . pathological fracture of the acetabulum leading to anterior hip dislocation in a patient with nf-1 has never been reported in the literature . the paper presents the clinical symp...
[ "this study aims to determine the usefulness of mandibular ramus as an aid in sex determination . hence , mandibular condyle and ramus , in particular , are generally the most sexually dimorphic as they are the sites associated with the greatest morphological changes in size and remodeling during growth . among var...	aims and objectives:(1 ) to determine the usefulness of mandibular ramus as an aid in sex determination . ( 2 ) to evaluate anteroposterior \| superioinferior angle of mandibular condyle.materials and methods : a retrospective study was conducted using orthopantomographs of 60 males and 60 females , which were taken usi...
[ "unfortunately , these nutrition - rich components are often discarded during milling out of ignorance , organoleptic reasons , and rancidity problems . knowing the phytochemical constituents and pharmacological profile of bran is expected to give insight to their potential application in promotion of health . bran...	cereal brans singly and in combination were blended at varying levels ( 5 and 10% ) for development of chapattis . cereal bran enriched chapattis were assessed for quality and physicochemical characteristics . on the basis of quality assessment , 10% enrichment level for chapatti was the best . moisture content , water...
[ "glaucoma is a progressive optic neuropathy leading to permanent visual loss that is often associated with elevated intraocular pressure ( iop ) . primary open - angle glaucoma ( poag ) is the most common type of glaucoma . although relatively higher iop , myopia , and older age are known to be factors associated w...	purpose : to investigate whether the glc3a locus harboring the cyp1b1 gene is associated with normal tension glaucoma ( ntg ) in japanese patients.materials and methods : one hundred forty - two japanese patients with ntg and 101 japanese healthy controls were recruited . patients exhibiting a comparatively early onset...
[ "recently , a single center study conducted by oiva and coworkers and published in critical care demonstrated that phospho - specific whole blood flow cytometry could be used to assess activated signaling path - ways in leukocytes isolated from pancreatitis patients . pancreatitis is an inflammatory process in wh...	recently , a single center study conducted by oiva and coworkers and published in critical care demonstrated that phospho - specific whole blood flow cytometry could be used to assess activated signaling pathways in leukocytes isolated from pancreatitis patients . the authors demonstrated that this methodology had the ...
[ "therefore , this study was undertaken to identify the determinants of prevailing misconceptions on diabetes and the management of diabetic patients registered at a diabetes clinic of a tertiary care hospital in the eastern region of saudi arabia . a few excellent studies about prevailing misconceptions about diabe...	objective : to identify the determinants of misconceptions about diabetes in patients registered with a diabetes clinic at a tertiary care hospital in eastern saudi arabia.materials and methods : this cross - sectional survey was carried out at a diabetes clinic of a tertiary care hospital in eastern saudi arabia , fro...
[ "thoracic injury can result in a wide range of clinical manifestations depending on the structures involved like chest wall , diaphragm , mediastinum , trachea , lungs parenchyma etc . while pulmonary contusion is commonly associated with blunt thoracic trauma , appearance of cavitary lesions variably described as ...	blunt thoracic trauma manifests in various ways , depending on the structures injured and type of injury . commonly manifested as parenchymal contusion , at times , pseudacavitation may also been seen on the chest x ray . they are to be differentiated from other causes of pulmonary cavitations which are often done base...
[ ". however , cerebral phaeohyphomycosis ( cp ) caused by darkly pigmented fungi appears to be a common exception to this rule because about one - half of this fungal infection occurred in patients with no underlying disease or risk factors . the authors illustrate a 75-year - old , immunocompetent male patient who ...	cerebral phaeohyphomycosis ( cp ) is a very rare but serious form of central nervous system fungal infection that is caused by dematiaceous fungi . it is commonly associated with poor prognosis irrespective of the immune status of the patient . in this study , the authors describe the first case of cp in korea that occ...
[ "the factors which mainly influence the outcome of the delivery can be summarised as the three ps of the labour : passageway , passenger , and power of the uterus . the purpose of this observational cohort study was to evaluate whether pelvic measurements , especially pelvic outlet , displayed any association wit...	objective . to evaluate whether pelvic measurements have any association with operative vaginal deliveries and the duration of the second stage of the delivery . study design . a retrospective study of pregnant women at an increased risk of fetal - pelvic disproportion during 20002008 in north - carelian central hosp...
[ "a close relationship between tmj and structures of the middle ear110 has been explained by the presence of the anterior mallear ligament ( aml ) , the sphenomandibular ligament ( sml ) and the discomallear ligament ( dml).2,3,8,1113 in the past , aml was accepted as an initial ligament lying between the middle ear...	objectivesto examine histological aspects of the ligaments between the middle ear and temporomandibular joint and suppose a theoretical role of their structural characteristics on mobility of mallear ossicle.methodsthe ligaments were obtained by microdissection of middle cranial fossa on both sites of 15 cadavers fixed...
[ "our working hypothesis is that using a don to control the distance between a dbd and a tad in order to match the distance between a proximal promoter element and a core promoter would enable the selective activation of a downstream gene . as a test system , we took advantage of the gal4uas system . we reasoned tha...	abstractthe unique structuredirecting properties of dna origami nanostructures ( dons ) show great potential to specifically manipulate intracellular processes . we report an innovative concept to selectively activate the transcription of a single gene in the developing zebrafish embryo . we reason that engineering a d...
[ "visfatin , also known as nicotinamide phosphoribosyltransferase ( nampt ) as well as pre - b - cell colony - enhancing factor , is a multifaceted protein with suggested enzymatic , immunological , and metabolic properties . visfatin has been analyzed in hypo- and hyperthyroidism in in vitro and in vivo studies , b...	we hypothesized that regulation of visfatin in hypothyroidism might be altered by coexisting chronic autoimmune thyroiditis . this is a prospective case - control study of 118 subjects . the autoimmune study group ( ait ) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic autoimmune thy...
[ "the purpose of the present study was to determine if ct-1 levels are significantly different in dhf patients compared to controls and to investigate the relationship between ct-1 and echocardiographic parameters . the plasma concentration of ct-1 is increased in various cardiovascular diseases such as congestive h...	summarybackgroundcardiotrophin-1 ( ct-1 ) is a member of the interleukin ( il-6 ) family of cytokines and is increased in various cardiovascular diseases , including chronic heart failure . the aim of the study was to determine if plasma ct-1 is associated with diastolic heart failure ( dhf ) and to investigate the rel...
[ "our research focused on peru , where gastric cancer is the leading cancer killer in men and women combined.15 thus , we searched the literature for reports of primary antibiotic resistance to h. pylori in peru . for example , meta - analyses of european and asian clinical data compared the standard triple therapy ...	objectivesgastric carcinoma is the most common cancer and cause of cancer mortality in peru . helicobacter pylori , a bacterium that colonizes the human stomach , is a group 1 carcinogen due to its causal relationship to gastric carcinoma . while eradication of h. pylori can help prevent gastric cancer , characterizing...
[ "we not only demonstrate an instructive role of neuronal activity in resting microglial motility , but also reveal , for the first time , a previously unappreciated function of microglia in homeostatic regulation of neuronal activity in the healthy brain ( fig . 2 ) . , we further proved that neural activity plays...	microglia are the primary immune cells in the brain . under pathological conditions , they become activated and participate in scavenging , inflammation and tissue repair in response to brain injury . while the function and underlying mechanism of activated microglia have been intensively studied in the past decades , ...
[ "thus , in this study , we assessed the frequency of top2a and dusp6 snps in a cohort of 140 chinese nsclc patients , and probed the association between top2a and dusp6 snps with radiotherapy response and overall survival . we aimed to identify top2a and dusp6 snp biomarkers that predict treatment response and surv...	backgroundmutations of dna topoisomerase ii ( top2a ) are associated with chemotherapy resistance , whereas dual - specificity phosphatase 6 ( dusp6 ) negatively regulates members of the mitogen - activated protein ( map ) kinase superfamily to control cell proliferation . this study assessed top2a and dusp6 single nuc...
[ "a 50-year - old male ( 182.9 cm , 78.5 kg ) was scheduled for arthroscopic debridement of the left shoulder . the patient had a history of old pulmonary tuberculosis and tb pleurisy ( 20 years ago ) and had no previous surgeries . we then attempted to perform a blind intubation by inserting a 6.5 mm reinforced end...	the airway management of patients with subglottic stenosis poses many challenges for the anesthesiologists . many anesthesiologists use a narrow endotracheal tube for airway control . this , however , can lead to complications such as tracheal mucosal trauma , tracheal perforation or bleeding . the asa difficult airway...
[ "we conducted a systematic review of the literature and meta - analysis to test for an association between perioperative bts and recurrence - free , cancer - specific , and overall survival in patients undergoing rc . we sought to assess the impact of bt on cancer - related outcomes and mortality in patients who ha...	background . perioperative blood transfusions are associated with poor survival in patients with solid tumors including bladder cancer . objective . to investigate the impact of perioperative blood transfusions on oncological outcomes after radical cystectomy . design . systematic review and meta - analysis . setting a...
[ ", we tested the effect of interferon proteins and of th1 , th2 , and th17 cytokines on the mucosal barrier structure and function of primary nasal epithelial cells harvested from nasal polyps of crs patients . chronic rhinosinusitis ( crs ) is characterized by severe inflammation of the sinus mucosa leading to blo...	cytokine mediated changes in paracellular permeability contribute to a multitude of pathological conditions including chronic rhinosinusitis ( crs ) . the purpose of this study was to investigate the effect of interferons and of th1 , th2 , and th17 cytokines on respiratory epithelium barrier function . cytokines and i...

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