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[ "the reasons for that may be related to factors such as rejection to the use of two hearing aids , financial issues , aesthetic reasons , problems with manual dexterity , very asymmetric losses , and central processing issues.19 \n given such reality , this work intends to analyze the effects of unilateral adaptat...	introduction hearing loss is one of the most common problems in the elderly population . besides compromising oral communication , it directly affects social relations and prevents elderly patients from living actively in society , possibly leading to the onset of depression or other conditions . objective to analy...
[ "ameloblastomas are rare benign odontogenic tumours , most commonly found in a patient s lower jaw . , i describe a woman who underwent a repair of her mandibular defect by a combination of innovative techniques , in order to reduce the risk of complications and get her back to an aesthetically pleasing level . the...	this case report describes a 35-year - old caucasian radiographer who presented with a significant mandibular bony defect following multiple excisions of an ameloblastoma . as a result , there was an absence of teeth on the lower - right mandible and a clear defect in the mandible . the treatment objectives were to reb...
[ "therefore , dpp4 inhibitor might be more effective in increasing circulating glp1 levels in patients with type 2 diabetes if they have low glp1 levels . based on these lines of evidence , we hypothesized that dpp4 inhibitor would be effective in patients with type 2 diabetes with high serum 3 pufa concentrations...	abstractaims / introduction : eicosapentaenoic acid ( epa ) stimulates glucagonlike peptide1 ( glp1 ) secretion in mice . we investigated the relationship between serum epa concentrations and the efficacy of dipeptidylpeptidase iv ( dpp4 ) inhibitor in patients with type 2 diabetes.materials and methods : serum e...
[ "pregnancy course was regular , except for maternal consumption of mebendazol at 5 weeks ' gestation to treat a pinworm infection . maternal history was negative for consumption of any known teratogenic class drug during the whole pregnancy . final diagnosis was that of a sporadic co. x - ray showing absence of lef...	key clinical messageclassic co ( also called iso kikuchi syndrome ) represents a benign , isolated condition associated with normal patient outcome . nevertheless , clinical follow - up and/or further clinically - based tests are needed to exclude other nail diseases associated with multisystem pathology ; complete fa...
[ "glycogen synthase kinase-3 ( gsk-3 ) , an evolutionarily conserved ubiquitous serine threonine kinase consisting of and isoforms , is a multifaceted protein with diverse cellular and neurophysiological functions . this article reviews the findings supporting the role of gsk-3 inhibition in mediating lithium s n...	the mood stabilizer lithium inhibits glycogen synthase kinase-3 ( gsk-3 ) directly or indirectly by enhancing serine phosphorylation of both and isoforms . lithium robustly protected primary brain neurons from glutamate - induced excitotoxicity ; these actions were mimicked by other gsk-3 inhibitors or silencing / in...
[ "studies have shown the incidence of injury from squash to range from 35.5 to 80.9 per 100,000 players . this is the first case reported of a patient sustaining such extensive head , neck and spinal injuries from a squash - related injury . craniofacial and spinal fractures typically result from high - energy blunt...	squash is a popular racquet sport not usually associated with severe head or spinal injury . the incidence of squash - related injury ranges from 35.5 to 80.9 per 100,000 players , with the most common sites being the lower - limbs and eyes . we present a case of extensive traumatic craniomaxillofacial and vertebral in...
[ "cdh1 expression is frequently absent in a variety of epithelial tumors , and loss of normal intercellular junctions results in promotion of cancer invasion and metastasis and is correlated with several types of cancers.1517 however , the association between and clinicopathological significance of cdh1 promoter hyp...	backgroundcdh1 is a protein encoded by the cdh1 gene in humans . mutations in this gene are linked with several types of cancer . loss of cdh1 function contributes to the progression of cancer by increasing proliferation , invasion , and/or metastasis . however , the association between and clinicopathological signific...
[ "the objective of this study is to quantify ncs repeatability utilizing the nc - stat ( neurometrix , inc . , waltham , massachusetts ) , an automated ncs system [ 810 ] . we hypothesized that use of the nc - stat system would yield highly reproducible ncs results . inter - tester variability refers to variability ...	abstractobjectiveto quantify nerve conduction study ( ncs ) reproducibility utilizing an automated ncs system ( nc - stat , neurometrix , inc.).methodhealthy volunteers without neuropathic symptoms participated in the study . their median , ulnar , peroneal , and tibial nerves were tested twice ( 7 days apart ) by the...
[ "this study was conducted within the north central cancer treatment group , a national cancer cooperative group that is funded in part by the national cancer institute . questionnaire and clinical trial data from two separate cancer therapeutic trials , n9921 and a cox proportional hazards model , which adjusted fo...	background : social support is defined as a network of family / friends who provide practical and emotional help . a sizable literature describes a direct relationship between social support and improved cancer clinical outcomes . this study explored the extent of social support and its potential association with survi...
[ "we hereby report a case of 41-year - old male patient who acquired pws about a year ago . acquired pwss are an uncommon entity developing later in life , but morphologically and histologically similar to the congenital lesions . port - wine stains ( pwss ) are congenital vascular malformations comprised of ectatic...	port - wine stains ( pwss ) are congenital vascular lesions caused by progressive ectasia of blood vessels located in the vascular plexus of the dermis . acquired pwss develop later in life but are identical in morphology and histology to the congenital pwss . less than 75 cases of acquired pwss have been reported in t...
[ "of the total 1338 lncrnas identified to be differentially expressed after ldir in either balb / c or spret / eij , 1337 had a significantly correlated expression pattern with at least one mrna that was also differentially expressed after ldir . however , the relevance of lncrnas in the cell and tissue response to ...	long noncoding rnas ( lncrnas ) are emerging as key regulators of diverse cell functions and processes . however , the relevance of lncrnas in the cell and tissue response to ionizing radiation has not yet been characterized . here we used microarray profiling to determine lncrna and mrna expression in mammary glands o...
[ "\n women with psychiatric diseases are treated with antipsychotic medication(s ) with limited evidence to support the safety of their use during pregnancy.olanzapine , a second - generation antipsychotic , is a us food and drug administration pregnancy category c drug with no unequivocal evidence of harm to the f...	there is a dearth of evidence on the safety of the use of antipsychotics during pregnancy . olanzapine , a pregnancy category c drug , has no unequivocal evidence of harm to the fetus . against this backdrop , we report the first case of a tracheo - esophageal fistula ( tef ) in a newborn following maternal antenatal ...
[ "\n\t\t\t\t olfactory neuroblastoma ( onb ) is a rare malignant tumor arising from the olfactory epithelium of the nasal cavity and the paranasal sinuses . additional information regarding the clinical course and outcome was collected from the patients ' charts and phone calls to the patients , their relatives , an...	objective . the aim of this study was to evaluate clinicopathological findings and the efficacy of the treatment modalities used in patients with olfactory neuroblastomas . study design . retrospective record review . setting . istanbul university , cerrahpasa medical faculty , medical oncology outpatient clinic . subj...
[ "our results suggest that bir either does not occur or is so infrequent that its role within the concert of dsb repair mechanisms can at best be a minor one in organisms with a large dna content ( > 1 mb ) per chromosome arm . unrepaired dsbs are usually lethal for dividing cells due to the subsequent loss of the ...	break - induced replication ( bir ) is considered as one way to repair dna double - strand breaks ( dsbs ) . bir is defined as replication of the proximal break - ends up to the end of the broken chromosome using an undamaged ( homologous ) double - stranded template and mimicking a non - reciprocal translocation . th...
[ "the experimental approaches used in the \n identification of the pacemaker , key enzymes , bottlenecks . thus , any metabolic pathway can be a potential \n therapeutic target . in the absence of a solid \n theoretical background that may build a strategy for the rational design of \n drugs , the \n answer to this...	the traditional experimental approaches used for changing the flux or the concentration of a particular metabolite of a metabolic pathway have been mostly based on the inhibition or over - expression of the presumed rate - limiting step . however , the attempts to manipulate a metabolic pathway by following such approa...
[ "the present review focuses on spindle burst activity in the cerebral cortex of the developing rat during the first postnatal week and summarizes our current understanding ( i ) on the functional properties of spindle bursts , ( ii ) the mechanisms underlying their generation , ( iii ) the synchronous patterns and ...	spontaneous and sensory evoked spindle bursts represent a functional hallmark of the developing cerebral cortex in vitro and in vivo . they have been observed in various neocortical areas of numerous species , including newborn rodents and preterm human infants . spindle bursts are generated in complex neocortical - su...
[ "the high incidence of atrazine to contaminate water resources and the increasing concern about the toxicological properties of atrazine has made researches directed toward bioremediation of atrazine in polluted sites . therefore , the main objectives of this research are evaluating the effects of carbon and nitrog...	atrazine herbicide that is widely used in corn production is frequently detected in water resources . the main objectives of this research were focused on assessing the effects of carbon and nitrogen sources on atrazine biodegradation by mixed bacterial consortium and by evaluating the feasibility of using mixed bacter...
[ "therefore , in this study , we determined the expression pattern of olig1 in neural cells during rat spinal cord development . exploring temporal and spatial expression and distribution of olig1 will contribute to our understanding of the role of olig1 in specialization of neural cells during development . althoug...	purposeour purpose was to systematically investigate the expression pattern and role of olig1 in neural cells during rat spinal cord development.animals and methodsspinal cord tissues were dissected from sprague dawley rats at embryonic day 14.5 ( e14.5 ) and e18.5 , postnatal day 0 ( p0 ) , p3 , p7 , postnatal 2 week...
[ "the purpose of \n this study was to apply joint mobilization and therapeutic exercise to the cervical spine \n and upper spine , investigate the effects on functional impairments caused by the neck pain , \n and examine differences between groups by comparing the intervention group with the group to \n which only ...	[ purpose ] this study evaluated joint mobilization and therapeutic exercise applied to the cervical spine and upper thoracic spine for functional impairment caused by chronic neck pain . [ subjects and methods ] eighteen study subjects were randomly assigned to two groups of nine people each . therapeutic exerci...
[ "adss obtained de - identified data for the entire population of alberta from alberta health and wellness administrative databases ( discharge abstract database , alberta physician claims data , ambulatory care classification system and vital statistics ) . odds ratios ( or ) and 95% confidence intervals were calcu...	objectivesto track and compare trends in diabetes rates from 1995 to 2007 for status aboriginal and general population youth.study designlongitudinal observational research study ( quantitative ) using provincial administrative data.methodsde-identified data was obtained from alberta health and wellness administrative ...
[ "tmc1 mrna is specifically expressed in neurosensory hair cells of the inner ear , and it is required for normal function of cochlear hair cells , although the molecular and cellular functions of the tmc1 protein are unknown ( 8) . mutations in the tmc1 gene have been associated with profound prelingual deafness ( ...	background : non - syndromic hearing loss ( nshl ) is the most common birth defect and occurs in approximately 1/1,000 newborns . nshl is a heterogeneous trait and can arise due to both genetic and environmental factors . mutations of the transmembrane channel - like 1 ( tmc1 ) gene cause non - syndromic deafness in hu...
[ "microleakage between the root canal filling and root - canal walls may adversely affects the results of root - canal treatment.1 apical leakage is considered to be common cause of endodontic failure.2 hence , different endodontic filling materials , sealers and techniques have been introduced to the dental communi...	background : the aim of this study was to quantitatively analyze the amount of dye leakage with ah26 , sealapex and tubliseal sealers in endodonticaly treated teeth.materials and methods : a total of 36 extracted mandibular molar specimens were divided into three groups ; group i : sealapex , group ii : tubliseal , gro...
[ "the early clinical trial data for the second - generation pde4 inhibitors cilomilast ( ariflo , glaxosmithkline , usa ) and roflumilast ( daxas , altana , germany ) all pointed to a successful introduction of a novel non - steroid anti - inflammatory therapy to clinicians in combating severe copd ( gamble et al 20...	targeting type 4 phosphodiesterase ( pde4 ) for treatment of copd has multilevel benefits to patients by reducing inflammation , relieving bronchoconstriction , and improving pulmonary circulation . the isoenzyme - specific narrow spectrum pde4 inhibitors such as cilomilast and roflumilast may have limited clinical eff...
[ "long - acting beta-2 agonists such as salmeterol and formoterol are important controller medications in the maintenance therapy of chronic stable asthma , used as an add - on drug to inhaled corticosteroid . however , their usefulness in the management of acute attacks of asthma has recently been recognized , and ...	arformoterol , a long - acting beta-2 agonist , has a rapid onset and long duration of action . its role as rescue medication in acute asthma attack is undetermined . to compare the efficacy and tolerability of arformoterol with salbutamol nebulization , a study was conducted among 50 patients with acute non - severe a...
[ "hepatic angiomyolipoma ( haml ) is a rare benign mesenchymal liver tumor first described by ishak in 1976 ; it belongs to a group of perivascular epithelioid cell tumors called pecoma . until date , , we have focused on the characteristic features of this tumor shown in imaging studies and by histological analys...	angiomyolipoma ( aml ) is a benign mesenchymal tumor that is frequently found in the kidney and , rarely , in the liver . the natural history of hepatic aml has not been clarified , and , because of the similar patterns in imaging studies , such as ultrasonography , computed tomography , and magnetic resonance imaging ...
[ "the sentinel node is defined as the first tumour - draining lymphatic filter , and its involvement by metastatic disease should predict the global nodal status of the specific patient . skip metastasis in the context of a normal sentinel node is described as a very rare event . in patients with clinically node - n...	summarybackgroundthe aim of this pilot trial was to study the feasibility of sentinel node percutaneous preoperative gamma probe - guided biopsy as a valid preoperative method of assessment of nodal status compared to surgical sentinel lymph node biopsy.material/methodsthis prospective study enrolled 10 consecutive pat...
[ "since the first fontan procedure was introduced by fontan in 1971 , the surgical technique has evolved and the survival rate has shown dramatic improvement . recently , several studies8,9,10,11,12 ) reported the pulmonary vasodilating therapy had an effective influence on fontan patients so we want to determine wh...	decreased exercise capacity after fontan surgery is relatively common and the failure of the fontan state gradually increases with age . however , there is no further treatment for patients with fontan circulation . pulmonary vasodilation therapy is an effective method to solve this problem because pulmonary vascular r...
[ "only two instances of this tumor arising in the tongue have previously been reported [ 1 , 2 ] . angiomyolipoma is a benign tumor that is histologically composed of groups of mature adipose tissue intermixed with convoluted thick - walled blood vessels , interlacing bundles , and irregularly arranged sheets of smo...	a 61-year - old woman was referred to our hospital with a mass in the left proglossis . the lesion was excised with a provisional diagnosis of hemangioma . the mass was well - demarcated and easily dissected with an ultrasonic surgical aspirator . the histopathologic diagnosis was angiomyolipoma arising in the tongue ....
[ "bone and immune system are functionally integrated through complex homeostatic networks and , in all respects , osteoporosis could be considered a chronic immune mediated inflammatory disease which shares clinical and biological features with many other inflammatory conditions , as well as of other immune mediated...	abstract : objectiveosteoimmunology investigates interactions between skeleton and immune system . in the light of recent discoveries in this field , a new reading register of osteoporosis is actually emerging , in which bone and immune cells are strictly interconnected . osteoporosis could therefore be considered a ch...
[ "lam involvement of the uterus is extremely rare and there have been only a few such reported cases ( 2 - 7 ) , and the imaging findings of uterine lam have only been briefly mentioned in two reports ( 2 , 5 ) . in this article , we report the cross - sectional imaging findings of extensive lam involving the uterus...	lymphangioleiomyomatosis ( lam ) is a rare idiopathic disease and this is characterized by a proliferation of abnormal smooth muscle cells in the lungs and in the lymphatic system of the thorax and retroperitoneum . the female genital tract is rarely affected by lam . we report here on the ct and mr imaging findings of...
[ "we performed the ts - dna gene sequence in 68 cancer samples from patients of different dukes ' stages ( a , b , and c ) and histological grade but we did not find any change in the ts - dna structure . this variant form presents a replacement of an evolutionary conserved tyrosine by a histidine at residue 33 of t...	thymidylate synthase ( ts ) catalyzes methylation of dump to dtmp and it is the target for the 5-fluorouracil ( 5-fu ) activity . barbour et al . showed that variant structural forms of ts in tumour cell lines confer resistance to fluoropyrimidines . we pl...
[ "however , because the number of japanese individuals enrolled in the global clinical trials was relatively limited ( 13 ) , the japanese ministry of health , labour and welfare required the market authorization holders to conduct a post - marketing surveillance study , called all cases surveillance ( 18 ) , as a c...	objectivepanitumumab was approved in japan in april 2010 for the treatment of kirsten rat sarcoma-2 virus oncogene wild - type unresectable and recurrent colorectal cancer . we conducted a post - marketing surveillance study to evaluate the safety and effectiveness of panitumumab.methodsafter panitumumab was commercial...
[ "it is classified into two clinical variants : the classical form , usually composed of multiple and grouped skin - colored , pedunculated and cerebriform nodules that often coalesce to form a plaque and a second more rare form , presenting as a solitary dome - shaped sessile papule or nodule.24 we report here eigh...	introductionnevus lipomatosus cutaneous superficialis ( nlcs ) is a rare benign hamartomatous skin tumor characterized by dermal deposition of mature adipose tissue . it s classified in two types : the classical form with multiple soft , pedunculated , cerebriform papules and nodules that coalesce into plaques , and th...
[ "hence , this study was carried out to investigate and compare the protective effect of administration of both tannic and gallic acids on normal and cisplatin induced nephrotoxicity in rats . extensive studies have been carried out on the protective effect of cotreatment and posttreatment of phenolic acids against ...	cisplatin ( cis - diamminedichloroplatinum ( ii ) or cddp ) , used in the treatment of many solid - tissue cancers , has its chief side - effect in nephrotoxicity . hence , this study sought to investigate and compare the protective effect of gallic acid ( ga ) and tannic acid ( ta ) against cisplatin induced nephrotox...
[ "although both orbital cavernous haemangiomas and schwannomas share many similar clinical and radiological characteristics [ 58 ] , it is important to distinguish between the tumours because they demonstrate important different features and the treatments of choice for the two are different [ 3 , 79 ] . consequentl...	objectiveit is important to distinguish between orbital cavernous haemangioma and schwannoma because the treatments of choice for the two tumours are different . the aim was to evaluate mr imaging findings distinguishing the two tumours.methodsmagnetic resonance imaging including t1- and t2-weighted imaging and contras...
[ "gingival enlargement is a common observation in clinical practice that may occur as a result of a response to varied stimuli and/or interactions with the host and the environment . such cases should be treated in a methodical manner , involving a detailed medical history followed by conventional nonsurgical therap...	clinicians are often intrigued by the varied manifestations of the gingival tissue . gingival overgrowth is a common clinical finding and most of them represent a reactive hyperplasia as a direct result of plaque - related inflammatory gingival disease . these types of growth generally respond to good plaque control , ...
[ "it is obvious that more the concentration of epinephrine , the better the control of bleeding , but there will be more cardiovascular changes . in spite of the effect of local anesthetics on vital signs , their accurate application is able to dramatically reduce stress . given the above bodies of evidence and the ...	background : changes in pulse rate and blood pressure are common consequences during oral surgeries . hypoxia during surgical process is another side effect . the objective of the present study was evaluation of blood hemoglobin oxygenation and hemodynamic changes during periodontal surgery.materials and methods : this...
[ "this study was therefore designed to investigate the prevalence of ckd in the korean population using knhanes samples , based on the definition and classification by kdigo 2012 guidelines , as well as the impact of changes through a comparison of the ckd - epi and mdrd study equations for the estimation of gfr , a...	background / aimsan updated chronic kidney disease ( ckd ) definition and classification were proposed by kidney disease : improving global outcomes ( kdigo ) , with adoption of a new equation to estimate glomerular filtration rate ( gfr ) and albuminuria to evaluate kidney structural damage . this study was performed ...
[ "while it is true that not all patients are able to dialyse themselves at home , it is a sad fact that many are never given the chance , despite the fact that patient choice has never been more discussed as an answer to almost any health care problem . although studies suggest that renal physicians and nurses rega...	pre - emptive living donor transplantation should always be promoted as the first - line treatment for kidney failure . where that is not possible , patients must receive timely information and advice regarding all dialysis options available , including home - based peritoneal dialysis and haemodialysis . where a dialy...
[ "ebv is a double stranded dna virus of the herpes virus family and is the most common virus affecting humans . ebv is mainly a b - lymphotropic and epitheliotropic virus and rarely infects t cells and nk cells . the epstein barr virus ( ebv ) was described by michael anthony epstein and yvonne barr , who isolated ...	lymphoproliferations associated with epstein barr virus ( ebv ) in adult patients pose a diagnostic challenge for pathologists for several reasons . first , the ebv lymphoproliferations represent a clinically and histologically very broad spectrum ranging from self - limiting lymphoproliferations to manifest malignant...
[ "the purpose of this study was to determine the effects of abz and mbz on the activity of the gst , alp and proteases in the protoscoleces of hydatid cyst and to evaluate their inhibitory effects on enzyme activity . echinococcosis or cystic hydatid disease is an endemic parasitic disease in human populations in ir...	background : hydatid cysts are formed in human body can be treated clinically by surgery or drugs such as albendazole ( abz ) and mebendazole ( mbz ) . the purpose of this study was comparing the effects of abz and mbz on glutathione - s - transferase , alkaline phosphatase and protease enzymes activities in protoscole...
[ "phased - array mri is recommended as the preferred imaging modality for regional staging . an established association exists with human papillomavirus ( hpv ) infection and premalignant intra - epithelial dysplasia . anal carcinoma is increasingly diagnosed in patients with human immunodeficiency virus ( hiv ) ...	backgroundsquamocellular anal carcinoma is increasingly diagnosed in patients with risk factors.methodsstate-of-the-art imaging with magnetic resonance imaging ( mri ) using phased - array coils and volumetric multidetector computed tomography ( ct ) provides detailed visualisation of anal disorders , identification an...
[ "the aim of the present work is to apply a specific isolation method based on the enrichment of black yeasts by simulating in batch solid state - like cultures the environmental conditions that are found in gas biofilters for the treatment of volatile aromatic hydrocarbons . despite the medical and environmental re...	black yeast members of the herpotrichiellaceae present a complex ecological behavior : they are often isolated from rather extreme environments polluted with aromatic hydrocarbons , while they are also regularly involved in human opportunistic infections . a selective technique to promote the in vitro growth of herpotr...
[ "the aim of our study was to perform a comparative validation of wc , bmi , whr , and whtr for defining the metabolic syndrome in indian population living in the urban and rural areas of rohtak district , haryana , india . we used the idf definition of metabolic syndrome , excluding the measure of obesity , to dete...	aims : to compare waist circumference ( wc ) , body mass index ( bmi ) , waist hip ratio ( whr ) , and waist - to - height ratio ( whtr ) and define an appropriate cut - off , which is most closely predictive of the non - adipose components of the idf metabolic syndrome ( mets ) definition.methods and results : a total...
[ ", we also demonstrated that gfp and a small water - soluble fluorescent molecule ( uranine ) could be encapsulated in the gvs . establishment of a method for preparation of gvs in which materials are densely packed is an important step for creating artificial cells . to confirm the utility of our protocol for vari...	the constructive biology and the synthetic biology approach to creating artificial life involve the bottom - up assembly of biological or nonbiological materials . such approaches have received considerable attention in research on the boundary between living and nonliving matter and have been used to construct artific...
[ "right sided valvular involvement in infective endocarditis has been well - described , but lesions affecting eustachian valve are distinctly rare . in 1986 , edwards et al . first described the entity of eustachian valve endocarditis ( eve ) in an autopsy study of a patient with overwhelming streptococcal sepsis ....	eustachian valve endocarditis ( eve ) is a distinctly rare and underdiagnosed entity . we report 2 new cases caused by vancomycin resistant staphylococcus aureus and staphylococcus hominis diagnosed on transesophageal echocardiography ( tee ) . although , 63% of eustachian valve endocarditis is caused by staphylococcus...
[ "the \n hypothesis tested was that there are significant differences in the surface area , volume \n and specific surface area among the different sizes of endodontic files . the aim of this study was to determine , for the first time , the surface area , volume and \n specific surface area of successive file sizes...	objectivethe aim of this study was to quantify the surface area , volume and specific surface area of endodontic files employing quantitative x - ray micro computed tomography ( mxct ) . material and methodsthree sets ( six files each ) of the flex - master ni - ti system ( n 20 , 25 and 30 , taper .04 ) were uti...
[ "a 2.15-kb fragment of human gip promoter with the a allele at rs3895874 , rs3809770 , rs3848460 , and rs937301 ( 2073 bp to + 77 bp ) was chemically synthesized ( genescript inc . , promoter fragments with ancestral haplotypes were obtained using the site - directed mutagenesis . in the promoter reporter study , e...	objectivealthough recent studies have shown that human genomes contain hundreds of loci that exhibit signatures of positive selection , variants that are associated with adaptation in energy - balance regulation remain elusive . we reasoned that the difficulty in identifying such variants could be due to heterogeneity ...
[ "the conventional definitions of pediatric adiposity depend on a measured body mass index ( bmi , kg / m ) interpreted relative to a reference distribution ( bmi normative growth charts ) for sex and age [ 13 ] . , we examined the performance of bmi z - score ( bmiz , referenced to cdc 2000 growth charts for the un...	convention defines pediatric adiposity by the body mass index z - score ( bmiz ) referenced to normative growth charts . waist - to - height ratio ( whtr ) does not depend on sex - and - age references . in the healthy study enrollment sample , we compared bmiz with whtr for ability to identify adverse cardiometabolic ...
[ "the bucky shuttle being the combination of nanosize carbon structures fullerene and nanotube , has many possible applications : nanoscale storage cells , devices for directed medicine transfer and containers for effective and safe gas storage [ 7 - 13 ] . the nanocapsule - specific structure defines its ads...	the processes of methane adsorption , storage and desorption by the nanocapsule are investigated with molecular - dynamic modeling method . the specific nanocapsule shape defines its functioning uniqueness : methane is adsorbed under 40 mpa and at normal temperature with further blocking of methane molecules the k@c601...
[ "we describe a young male who developed mania while on amisulpride , a newer antipsychotic drug introduced in india . it is an unusual \" atypical \" antipsychotic , as the \" atypical \" profile of the new antipsychotics clozapine , olanzapine , quetiapine , and risperidone has been linked to combined antagonism o...	amisulpride is an atypical antipsychotic used for the management of schizophrenia and other conditions like dysthymia . it has also been used for the management of bipolar disorders as an add on therapy . here , we report a patient of schizophrenia who developed a manic episode while on amisulpride .
[ "this study attempted to evaluate the regional metabolic disorders using h mrs within the frontal , external and medial temporal lobes in patients with mci , as a predictor of clinical deterioration to dementia based on clinical follow - up . we observe the lowering of perfusion and metabolism of glucose and oxygen...	summarybackgroundpurpose of study was evaluation of regional metabolic disorders using 1h mrs in patients with mci , as a predictor of clinical conversion to dementia based on clinical follow-up.material/methodsthe study group consisted of 31 subjects with diagnosis of mci based on criteria the mayo clinic group . 1h m...
[ "intraocular pressure ( iop ) is one the most important modifiable risk factors for glaucoma progression.13 iop measurements in the ophthalmology clinic are often limited to office hours , which do not fully represent the nychthemeral iop peaks and fluctuations.4,5 previously , 24-hour iop monitoring studies have r...	purposeto analyze the 24-hour ocular dimensional profile in normal - tension glaucoma ( ntg ) patients on medical treatment.methodsconsecutive , medically treated ntg subjects were recruited from a university eye center . subjects were on a mean of 1.70.7 types of antiglaucoma medications and 56.6% were on a prostaglan...
[ "we share a novel , simple surgical approach to management of a case of chronic traumatic cyclodialysis cleft with a successful outcome . cyclodialysis cleft is a rare clinical finding , but one that can have significant ocular complications , including decreased vision , shallowing of the anterior chamber , cornea...	cyclodialysis cleft is a rare clinical finding and therefore , reports on surgical repair techniques in the literature are limited . additionally , hypotony can make repair technically challenging . we share a novel , simple surgical approach to management of a case of chronic traumatic cyclodialysis cleft with a succe...
[ "after concentration of the filtrate under reduced pressure , the resulting oil was purified by flash column chromatography ( etoac in hexane ) to afford alcohol 21 ( from 20 ) or 26 ( from 13 ) as a colorless oil . concentration under reduced pressure followed by purification of the residue by flash column chromat...	a concise route to the 6-azido-6-deoxy--galactosyl - phytosphingosine derivative 9 is reported . orthogonal protection of the two amino groups allows elaboration of 9 into a range of 6-n - derivatized -galactosyl ceramides by late - stage introduction of the acyl chain of the ceramide and the 6-n - group in the sugar h...
[ "we report a rare case of acute mastitis caused by enteric organisms passing through a cp shunt catheter , which had penetrated the transverse colon , and was related to a previous failed attempt to remove the shunt resulting in a divided catheter . ventriculoperitoneal and cystoperitoneal ( cp ) shunts are commonl...	we report a rare case of acute mastitis caused by enteric organisms passing through a cystoperitoneal shunt catheter , which had penetrated into the colon . the patient is a 56-year - old woman who underwent shunt placement for cyst formation after surgery for meningioma at the age of 29 . after 26 years , she suffered...
[ "we explore , in mice , the possibility of diagnosing an early - melanoma tumor and following its growth by analyzing the changes that occur throughout the pathological process in vocs excreted in urine and feces . this study will contribute to the development of a noninvasive and reliable diagnostic procedure to d...	melanoma is the most malignant type of skin cancer . early detection of melanoma is thus critical for patient prognosis and survival . at present , examination by a skilled dermatologist followed by biopsy of suspicious lesions is the diagnostic gold standard . the aim of the present study was to examine an alternative...
[ "using these approaches , we demonstrate a role for clec12a in antibacterial autophagy and pinpoint a functionally relevant interaction node of clec12a with an e3 ligase complex that is important for this function . the autophagy pathway targets only a subpopulation of bacteria within a cell , and little is known a...	summarythe polymorphism atg16l1 t300a , associated with increased risk of crohn s disease , impairs pathogen defense mechanisms including selective autophagy , but specific pathway interactions altered by the risk allele remain unknown . here , we use perturbational profiling of human peripheral blood cells to reveal t...
[ "niv was implemented as an add - on modality in an acute medical ward and a respiratory ward at odense university hospital , odense , denmark , in 2004,4 based on local instructions and national recommendations,5 and the modality has since been used as a standard additional treatment primarily for patients with hyp...	implementation of noninvasive ventilation ( niv ) as an add - on treatment has been routinely used in a non - intensive care setting since 2004 for patients with chronic obstructive pulmonary disease ( copd ) and acute hypercapnic respiratory failure at a university hospital in denmark . although randomized controlled ...
[ "takayasu arteritis ( ta ) is a chronic inflammatory arteritis affecting the aorta and its main branches . the occurrence of the disease in young children and infants is extremely rare with only a few cases reported all over the world . the disease has a world - wide distribution , but has a high prevalence in japa...	takayasu arteritis ( ta ) , a chronic inflammatory arteritis affecting the aorta and its main branches , is a rare condition mainly affecting young women in the second and third decades of life . occurrence of ta in infants is extremely rare , with only less than 10 cases reported all over the world until date . we rep...
[ "however , its widely used was limited by the expensive costs , shortage of donor organs and invasive procedure ( 1 ) . hepatocyte transplantation has emerged as a feasible alternative to liver transplantation in some liver diseases ( 2 ) , but it is limited by organ donors and the low cell quality of available liv...	adult stem cells ( ascs ) are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues , which are the powerful sources for cell therapy and tissue engineering . bone marrow - derived mesenchymal stem cells ( bmscs ) , adipose tissue - derived mesenchymal stem...
[ "waldenstrom 's macroglobulinemia ( wm ) is the result of a clonal proliferation of lymphocytes that produce monoclonal immunoglobulin m ( igm ) . the hyperviscosity syndrome is characterized by headache , tinnitus , vertigo , blurred vision , and chronic bleeding from the nose and gums ( 3 ) . it is now considered...	waldenstrom 's macroglobulinemia is an uncommon low - grade b - cell lymphoproliferative disorder in which monoclonal immunoglobulin m is produced . neurological symptoms due to hyperviscosity are frequent manifestations of waldenstrom 's macroglobulinemia . however , central nervous system infiltration by plasmacytoid...
[ "the objective of our study was to determine how maternal physical activity , maternal insulin sensitivity ( isogtt ) , prepregnancy bmi , infant feeding practices ( breastfeeding duration , age of introduction of formula , and complementary foods ) , and screen time contribute to infant weight gain and adiposity a...	increasing evidence supports the contribution of intrauterine environmental exposures on obesity risk in offspring . few studies have included maternal and infant lifestyle factors . our objective was to study the impact of maternal physical activity , infant feeding , and screen time on offspring weight gain and adipo...
[ "phylogenetic networks represent the evolutionary relationships of taxa , including sequences , genes , chromosomes , genomes , or species . specifically , we will quantify the different classes of networks ( regular , tree sibling , tree child , and galled trees ) produced by the coalescent as a function of the po...	phylogenetic networks aim to represent the evolutionary history of taxa . within these , reticulate networks are explicitly able to accommodate evolutionary events like recombination , hybridization , or lateral gene transfer . although several metrics exist to compare phylogenetic networks , they make several assumpti...
[ "we compared the effects of these diets on the development of dental caries in a diabetic rodent model focusing on the difference in hardness between the powdered and pelletized diets . we recently demonstrated that diabetes directly induced dental caries in rats and mice , although a direct association between the...	we have previously shown that dental caries may be produced in diabetic rodent models fed with noncariogenic standard diets ; however , many studies usually add large amounts of sugar to the diet to induce dental caries . moreover , the physical properties of cariogenic diets have been reported as an important factor i...
[ "we conclude that volume exclusion in the presence of a crowding agent such as peg or dextran can be used as a general route to increase encapsulation efficiency of biomacromolecules in both giant and submicrometer lipid vesicles , up to levels expected for passive encapsulation of lower mw solutes ( i.e. , cin = c...	large solutes such as high molecular weight proteins can be difficult to encapsulate in lipid vesicles . passive trapping of these macromolecular solutes during vesicle formation typically results in concentrations inside the vesicles that are much lower than in the external solution . here , we investigated the effect...
[ "we collected all possible literature from the year 1972 ( when kfd was first described ) to the present day conducting a medical search on kikuchi fujimoto disease ( kfd ) in english language . we included publications in authorized medical journals including original and review articles / theses , editorials , ca...	in order to determine the clinical significance of kikuchi fujimoto disease ( histiocytic necrotizing lymhadenitis ) and to review the literature available on this condition , we selected the medicine research papers in english language published between the years 1972 to 2011.kikuchi fujimoto disease ( kfd ) is an unc...
[ "whose attending physician is unsure regarding which modality will be optimal , the results demonstrate a very low feeding success rate with enteral nutrition and that complications are related to the duration of nutritional treatment , regardless of the mode of administration . in general terms it has repeatedly b...	systematic undernutrition of intensive care unit patients is common and neglected . is this inevitable or can better routines and protocols make a difference ? the necessity of feeding may be regarded as self - evident , but more evidence is obviously needed to strengthen this issue . in rich countries it should be a h...
[ "this conclusion is strongly supported by the lack of autoimmune manifestations and changes in thymocyte maturation upon foxn1-cre mediated ablation of a conditional foxp3 allele in the thymic epithelium . in contrast , in control experiments , foxp3 ablation in the t cell lineage resulted in lethal autoimmune pat...	foxp3 is essential for the commitment of differentiating thymocytes to the regulatory cd4 + t ( t reg ) cell lineage . in humans and mice with a genetic foxp3 deficiency , absence of this critical t reg cell population was suggested to be responsible for the severe autoimmune lesions . recently , it has been proposed t...
[ "we herein , report hpv b19 induced aplastic crisis in an asymptomatic and undiagnosed family of three with hs demonstrating pancytopenia on peripheral blood . several similar sporadic cases have been reported by now , but familial hpv b19 induced aplastic crisis leading to the diagnosis of hs in all family members...	human parvovirus ( hpv ) b19 induced aplastic crisis in a family leading to the diagnosis of hereditary spherocytosis ( hs ) is a very rare condition being barely reported in the literature . we herein report a 4-year - old girl , her brother , and their mother who all presented with progressive pallor and jaundice aft...
[ "here , we have tested the therapeutic efficacy of these strategies on a genetic mitochondrial disease model , the sco2 knockout / knockin ( sco2 ) mouse ( yang et al . , 2010 ) . primary mitochondrial disorders due to impaired oxidative phosphorylation ( oxphos ) are a well - established cause of severe disabilit...	summarymitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain . pharmacological activation of mitochondrial biogenesis has been proposed as an effective means to correct the biochemical defects and ameliorate the clinical phenotype in these severely d...
[ "the purpose of this case report is to describe a patient who developed acute paralysis and aphasia while receiving her initial infusion of irinotecan . irinotecan is commonly used in combination with oxaliplatin as a component of folfirinox chemotherapy for several gastrointestinal malignancies .", "a 67-year - ...	backgroundirinotecan is commonly used in combination with oxaliplatin as a component of folfirinox chemotherapy for several gastrointestinal malignancies . the purpose of this case report is to describe a patient who developed acute paralysis and aphasia while receiving her initial infusion of irinotecan.case reporta 6...
[ "given the studies that suggest the preferential involvement of prefrontal cortex among brain structural and functional alterations in alcohol dependence , we hypothesized that patients with alcohol dependence would have thinner prefrontal cortex in comparison with healthy comparison subjects , after correcting for...	alcohol dependence is a serious disorder that can be related with a number of potential health - related and social consequences . cortical thickness measurements would provide important information on the cortical structural alterations in patients with alcohol dependence . twenty - one patients with alcohol dependenc...
[ "the purpose of this study was to examine and compare nutrient intake , dds , mar and health behaviors of asan residents by the three distinctive regions . evaluating the dietary diversity score ( dds ) and mar are , therefore , a good way to predict quality of diet and the entirety of dietary habits . in this stud...	inadequate dietary intakes and poor health behaviors are of concern among rural residents in korea . this study is conducted to compare dietary intakes , dietary diversity score ( dds ) , mean nutrient adequacy ratio ( mar ) and health related behaviors by rural , factory and urban areas in asan . a total of 930 adults...
[ "skin side effects of such drugs have few data available in the literature , although the number of reports has been increasing in the last years , including cosmetic filler site injections . it is well known that cutaneous side effects of treatment with ifnalpha alone or ifnalpha plus ribavirin in patients with ch...	the treatment of chronic hepatitis c ( chc ) has evolved in the past 15 years and combination of pegylated interferon plus ribavirin is its current standard therapy . however , several side effects are commonly observed and frequently lead to transient or definitive interruption of treatment . although sarcoidosis in i...
[ "primary sites of occurrence of extrapulmonary pleomorphic carcinomas have been described in other organs such as the stomach , thyroid , gallbladder , pancreas , kidney , liver , bladder , and colon . to the best of our knowledge , only one report described a case of giant cell carcinoma of the colon resembling th...	pleomorphic carcinoma is an aggressive neoplasm defined by the world health organization ( who ) as a poorly differentiated ( squamous cell carcinoma or adenocarcinoma ) or undifferentiated carcinoma in which at least 10% spindle and/or giant cells are identified , or as a carcinoma constituted purely of spindle and gi...
[ "management of suspected scaphoid fractures with normal x - rays at emergency department ( ed ) presentation is a common clinical challenge . there has long been concern that failure to identify and immobilise a scaphoid fracture might result in avascular necrosis or non - union with significant functional impact f...	aimto characterise current management of adult patients with possible occult scaphoid fracture in australasian emergency departments.methodsinternet-based survey of directors of emergency medicine training throughout australasia . data collected included the most common management used in ed for patients with possible ...
[ "thus , this study was conducted with following objectives among interstate female migrants . \n to study socioeconomic and demographic profile of migrant womento estimate proportion of women utilizing full anc package and reasons for nonutilization of full anc servicesto estimate the proportion of institutional de...	introduction : migrant is a vulnerable population . they face several barriers in accessing health services . the immigration status presents various challenges for maternity services utilization . so this study was conducted ( 1 ) to estimate proportion of women utilizing full anc package and to find out reasons for i...
[ "hence , to explore the mechanism of actions of daidzein , its effect on cell proliferation , mammary gland differentiation , and the expression of ers in a prepubertal mammary tumour model was carried out . although daidzein also has the ability to bind to the ers , the precise mechanism of action by which it show...	mechanism of chemoprevention by daidzein ( 500 g / g bwt ) was examined by injecting it subcutaneously at 16th , 18th , and 20th day postpartum , followed by counting of terminal end buds ( tebs ) , terminal ducts ( tds ) , and lobules and immunohistochemistry of er- , bcl2 , bax , and caspase-3 . dna fragmentation ...
[ "the prevalence of faecoliths in the general population is 3% , and appendicoliths are seen in 10% cases of acute appendicitis . faecoliths formed by mineral deposits layered with faecal debris and lodged in the appendix are called appendicoliths . acute appendicitis , one of the commonest surgical emergencies , af...	acute appendicitis is one of the commonest surgical emergencies worldwide . there is considerable variation in prevalence of appendicoliths with appendicitis . most of the patients with appendicoliths are asymptomatic and they are not pathognomic for acute appendicitis . however , appendicoliths show increased associat...
[ "it is commonly treated with conservative surgery ; prognosis is rapidly improved by performing concomitant chemotherapy after the initial surgery.1,2 gliomatosis peritonei is the metastatic implantation of mature glial tissue within the peritoneal cavity of patients with ovarian teratomas.3 as second - look or sec...	we report a patient who has maintained a regular menstrual cycle despite undergoing cystectomy and chemotherapy for contralateral recurrence of ovarian immature teratoma with gliomatosis peritonei . we initially performed a fertility - sparing right salpingo - oophorectomy , omentectomy and peritoneal biopsy for immatu...
[ "the purpose of this study was to determine cesarean birth rates and to find out social factors affecting the cesarean birth in primiparous women . cesarean delivery rates have been increasing in a fast manner throughout the world within past few decades ( 1 ) . although reasonable cesarean rates have been proposed...	background : p cesarean delivery rates have been increasing throughout the world . parallel to the developments in the world the cesarean rate in turkey has risen to 48.1% in 2013 . some of the social factors were related with cesarean births . the purpose of this study was to determine cesarean birth rates and to find...
[ "las fracturas por fragilidad asociadas a la osteoporosis suponen un gran coste econmico y personal para la sociedad . aunque los productos lcteos son una buena fuente de calcio , los pacientes que no pueden digerir la lactosa tienden a evitarlos y tienen un mayor riesgo de fractura que la poblacin general .", "1...	background : fragility fractures associated with osteoporosis extract a large financial and personal toll on society . pharmaceutical or dietary calcium intake is needed to increase bone mineral density to prevent fragility fractures . although dairy products are a good source of calcium , patients who are unable to di...
[ "the present manuscript sought to exploit dab photo - oxidation of mag - fura 2 for visualizing er ca distribution in hela cells , which are among the most widespread model cell lines used for studying intracellular ca signaling . this method combines the specificity of available fluorophores to the high spatial re...	we propose a tool for a rapid high - resolution detection of calcium ions which can be used in parallel with other techniques . we have applied a new approach by photo - oxidation of diaminobenzidine in presence of the emission of an excited fluorochrome specific for calcium detection . this method combines the selecti...
[ "nearly , 90% of metastatic tumors occur in jaw bones , especially premolar - molar region of the mandible , whereas metastases to soft tissues are extraordinarily rare and account for 0.1% of all oral malignancies . hence , this article emphasizes on detailed dentoalveolar examination and early diagnosis for findi...	oral cavity is an uncommon site for metastasis and is usually an evidence of widespread disease . the clinical presentation of the metastatic lesions differs between the various sites in the oral region . metastatic tumors account for 13% of all oral malignancies . the jawbones , particularly the mandibular molar area ...
[ "wisconsin card sorting test ( wcst-64 ) is a neuropsychological test for assessing problem solving , sorting , abstract thinking , ability to maintain concepts and cognitive flexibility skills which are related to performances of the frontal lobe . in this test all cases in the study and the control group were mat...	objectivethe aim of this study was to examine the differences between adhd subtypes in executive function tasks compared to themselves and normal controls.methodin this study , 45 school aged children with attention deficit hyperactivity disorder ( adhd ) and 30 normal children who were matched based on age and iq scor...
[ "the visual environment provides a vast assortment of information to the sighted individual during the acts of daily living . for the visually - impaired individual , our proposed device uses a vibrotactile stimulator to provide visual information gathered from a color camera system . we believe that this placement...	we present a novel device mounted on the fingertip for acquiring and transmitting visual information through haptic channels . in contrast to previous systems in which the user interrogates an intermediate representation of visual information , such as a tactile display representing a camera generated image , our devic...
[ "it negatively influences the child 's quality of life and is an important cause of absence from school and also a significant factor in health - related costs among children and adolescents . frequency of headache increases with age in this population . in the present study we aimed to determine epidemiologic char...	objectiveheadache is one of the most common neurologic problems in children and adolescents . primary headache including migraine and tension - type headache comprises the vast majority of headaches and are associated with marked incidence , prevalence , and individual and social cost . we aimed to assess demographic c...
[ ". the study will evaluate overall survival of metastatic colorectal cancer patients with cachexia who are administered the mab as a monotherapy . the efficacy and safety of induction and four maintenance regimens of brodalumab compared with placebo and ustekinumab in patients with moderate - to - severe plaque pso...	the transitions of antibody therapeutics to late - stage clinical development , regulatory review and the market are proceeding at a rapid pace in 2013 . since late 2012 , two monoclonal antibody ( mab ) therapeutics ( itolizumab , trastuzumab emtansine ) received their first approvals , first marketing applications fo...
[ "they may be seen in midline or para - axial location , from the brain to the sacral area . the oropharyngeal cavity is exceedingly rare for teratomas , 2% of all teratomas , present as large masses protruding from the oropharyngeal area . they display a particular tendency to locate in the sacrococcygeal and pre -...	for congenital teratomas , oropharyngeal cavity is one of the rarest sites ( 2% of all teratomas ) . they are rarely picked up by prenatal ultrasonography . postnatally , newborns present with respiratory distress and at this point role of pediatricians is very crucial in establishing secure airway after which they nee...
[ "the rationale underlying treatment recommendations based on esthetic impairment come from the social science researches , which indicate that unacceptable dental appearance may stigmatize , impede career advancement and peer group acceptance , encourage negative stereotyping , and have a negative effect on self - ...	aim of the study : the purpose was to assess orthodontic treatment need in a subpopulation as assessed by the orthodontists.materials and methods : the study was conducted on a sample population of 753 patients aged 2025 years to assess the need for orthodontic treatment using the esthetic component ( ac ) of the index...
[ "thus , understanding how nuclear shape is regulated and identifying genes that contribute to nuclear morphology are of interest from both a medical and a basic biology standpoint . in order to proliferate , cells must accurately transmit their chromosomes from one generation to the next . in eukaryotes , the nucle...	in eukaryotes , chromosomes are encased by a dynamic nuclear envelope . in contrast to metazoans , where the nuclear envelope disassembles during mitosis , many fungi including budding yeast undergo closed mitosis , where the nuclear envelope remains intact throughout the cell cycle . consequently , during closed mit...
[ "fibro - osseous lesions ( fol ) are a poorly defined group of lesions affecting the jaws and craniofacial bones . recent world health organization classification ( 2005 ) for fibro - osseous lesions was considered while sub - dividing these into various groups [ table 1 ] . the aim of this study was to analyze var...	background : fibro - osseous lesions ( fols ) are one of the commonest entities reported in the head and neck region . however , studies on these groups of lesions on indian population were not carried out before . so this motivated us to analyze the clinico - pathologic correlation of fibro - osseous lesions reported ...
[ "this paper was focused on developing a rapid analysis method for discriminating specific subproducing areas of longjing tea by electronic tongue and chemometrics . longjing tea is a green tea produced in xihu and its surrounding areas ( hangzhou , china ) . as a famous green tea with protected designation of origi...	the feasibility of electronic tongue and multivariate analysis was investigated for discriminating the specific geographical origins of a chinese green tea with protected designation of origin ( pdo ) . 155 longjing tea samples from three subareas were collected and analyzed by an electronic tongue array of 7 sensors ....
[ "in accordance with the aforementioned dose response relationship , it was hypothesized that muscle protein accretion would be greater with the higher frequency program . therefore , the main purpose of this investigation was to analyze the effect of rt performed at different weekly frequencies on flexibility in u...	objectivethe main purpose of the investigation reported here was to analyze the effect of resistance training ( rt ) performed at different weekly frequencies on flexibility in older women.participants and methodsfifty - three older women ( 60 years old ) were randomly assigned to perform rt either two ( n=28 ; group ...
[ "a fasta database file of all human ecm proteins was constructed . for both human and bovine samples , comprehensive lists of ecm proteins for human and mouse have been compiled ( http://matrisomeproject.mit.edu , in the public domain ) , and the lists of core and ecm - associated proteins for human were used to ex...	purposethe zonule of zinn ( ciliary zonule ) is a system of fibers that centers the crystalline lens on the optical axis of the eye . mutations in zonule components underlie syndromic conditions associated with a broad range of ocular pathologies , including microspherophakia and ectopia lentis . here , we used hplc m...
[ "the subtype of 19 well - characterized breast cancer cell lines was obtained by use of gene expression profiling , including normal - like , basal - like , her2-positive , and luminal a and b. cells from each line were mixed with blood from a healthy donor and subjected to the cellsearch circulating tumor cell ass...	identification of specific subtypes of circulating tumor cells in peripheral blood of cancer patients can provide information about the biology of metastasis and improve patient management . however , to be effective , the method used to identify circulating tumor cells must detect all tumor cell types . we investigate...
[ "pcr is a new alternative to existing diagnostic procedures , such as direct smear of parasites from clinical specimens or by cultivation , with microscopic examination . zoonotic cutaneous leishmaniasis ( zcl ) is polymorphic disease with various clinical manifestations ( 1 , 2 ) . leishmaniasis , a group of paras...	backgroundzoonotic cutaneous leishmaniasis ( zcl ) is polymorphic disease that may show various clinical manifestations.objectivesthis study investigates the determination of genetic variation within the species of leishmania major isolates from new cases in chabahar , a port city in southeast iran ( situated at the ir...
[ "recently , improvement and progress in outcomes have been observed through better understanding of the disease , finding the effective factors in the start and progression of the disease , and ultimately in better management of the disease ( 16 ) . in addition , the research results could have an effective role in...	backgroundoutcomesforcystic fibrosis patients are improving rapidly . the demographic factors are notable variables inoutcomes , which can be evaluated and modified.objectivesthis study was designed to investigate the association between outcome and demographic factors in patients with cystic fibrosis.patients and meth...
[ "the original technique of staining the anterior capsule with trypan blue ( tb ) in eyes with no red reflex involves the injection of the dye with a cannula after filling the anterior chamber with an air bubble.1 the stability of the anterior chamber can be compromised by air escaping when the cannula is introduced...	the original technique of staining the anterior capsule of the lens with trypan blue involves the injection of an air bubble in the anterior chamber . a drawback of this technique is the possible instability of the anterior chamber caused by the sudden exit of air when the dye is injected with the cannula through the s...

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