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[ "most commonly affects people of african descent . in nigeria , sickle cell anaemia affects about 1 - 3% of the nigerian population . couples at risk for the transmission of genetic diseases can now choose ivf and pgd to avoid the problem of selective abortion that is associated with pre - natal diagnosis during pr...	a couple , both carriers of the sickle cell anaemia trait ( genotype hbas ) with an offspring already affected with the genetic disease underwent a pre - implantation genetic diagnosis / polymerase chain reaction screening of biopsied blastomeres . dna analysis of single blastomeres was carried out to find out indicate...
[ "we previously reported pulse rate - associated loci from the korea association resource ( kare ) genomewide association study ( gwas ) , comprising 8,842 samples in the korean population . in this study , we extended the previous study and reexamined the relevance of pulse rate - associated single - nucleotide pol...	pulse rate is known to be related to diverse phenotypes , such as cardiovascular diseases , lifespan , arrhythmia , hypertension , lipids , diabetes , and menopause . we have reported two genomewide significant genetic loci responsible for the variation in pulse rate as a part of the korea association resource ( kare )...
[ "this complication usually occurs during abdominal aortic surgery and is an unusual complication following live donor nephrectomy . therefore , it is of utmost importance to minimize the risks of this procedure and thus maximize donor safety . live kidney donors are healthy individuals who willingly undergo major s...	we present the first case report of chylous ascites following total robot - assisted donor nephrectomy . a 39-year - old female underwent a transperitoneal left - sided total robot - assisted donor nephrectomy . the procedure was uneventful and the patient was discharged without any symptoms . at postoperative day 29 ,...
[ ", we aimed to investigate the influence of obesity on the association between epicardial fat thickness ( eft ) and circadian bp changes in patients with recently diagnosed essential hypertension ( eh ) , with a gender subgroup analysis . furthermore , a higher prevalence of hypertension among overweight adults is ...	this study aimed to investigate the effects of gender on the association between epicardial fat thickness ( eft ) and circadian blood pressure ( bp ) changes in patients with recently diagnosed essential hypertension ( eh ) . a total of 441 patients with eh ( male / female : 236/205 , mean age : 50.7 13.8 ) and 83 con...
[ "during the past 2 decades , laparoscopic surgery has gained worldwide popularity resulting from its well - known characteristics of less postoperative pain , fewer complications , earlier discharge , and better cosmesis . keyless abdominal rope - lifting surgery ( kars ) is a novel , gasless ( isobaric ) , single ...	background and objectives : keyless abdominal rope - lifting surgery is a novel , gasless , single - incision laparoscopic surgical technique . in this study we aimed to compare the postoperative pain from keyless abdominal rope - lifting surgery with carbon dioxide laparoscopy performed for benign ovarian cysts.method...
[ "precise identification of risk factors is of great importance for recognition of high - risk cases in which ercp should be avoided if possible or protective modalities should be considered to minimize patients risk of morbidity and mortality . the present study examined prospectively the potential patient- and pro...	backgroundpancreatitis remains the most common complication of endoscopic retrograde cholangiopancreatography ( ercp ) , resulting in substantial morbidity and occasional mortality . there are notable controversies and conflicting reports about risk factors of post - ercp pancreatitis ( pep).aimto evaluate the potentia...
[ "the aim of the study was to evaluate and compare the efficacy of 4% articaine hydrochloride and 2% lignocaine hydrochloride for the orthodontic extraction . it also contains maximum 0.6 mg na - sulfite in 1.0 ml and sodium chloride . once injected , absorption starts from the site of injection into the vascular co...	background : articaine in an anesthetic agent , which is used less frequently in dentistry . it differs from other agents due to the presence of a thiophene ring in its molecular structure . few groups of researchers claim that it is superior to lignocaine . hence , the purpose of this study was to compare the efficacy...
[ "rassf1 isoform a ( rassf1a ) is the most characterized member of the rassf family . importantly , all isoforms contain a ras association ( ra ) domain either in their c - terminal ( rassf1 - 6 ) or n - terminal ( rassf7 - 10 ) regions . to date , no known catalytic activity has been described for this family , and...	the rassf proteins are a family of polypeptides , each containing a conserved ras association domain , suggesting that these scaffold proteins may be effectors of activated ras or ras - related small gtpases . rassf proteins are characterized by their ability to inhibit cell growth and proliferation while promoting cel...
[ "we report the case of an adult woman with psoriatic arthritis who developed acute severe hepatitis following long - term treatment with mtx . it is one of the most commonly used medicines in the treatment of rheumatoid arthritis or psoriatic arthritis .", "mtx was stopped in the year 2005 due to remission of the...	methotrexate ( mtx ) is one of the most commonly used medicines in the treatment of psoriatic arthritis . the drug can produce steatosis and cirrhosis . autoimmune hepatitis is a rare and serious adverse effect . we describe the case of a 53-year - old woman who developed autoimmune hepatitis after a long - term use of...
[ "mirizzi syndrome is a rare complication of cholecystolithiasis characterized by jaundice due to compression of the common hepatic duct . the diagnosis may not be immediately apparent , and management is controversial with open surgery still recommended by some authors .", "laparoscopic retrograde ( fundus first ...	background : mirizzi syndrome is a rare complication of cholecystolithiasis characterized by jaundice due to compression of the common hepatic duct . the diagnosis may not be immediately apparent , and management is controversial with open surgery still recommended by some authors.method:a case is detailed herein of a ...
[ "dirofilaria immitis ( the canine heartworm ) is a filarial nematode naturally hosted by dogs , cats , foxes , muskrat , raccoons , and bears . pathologically , spherical subpleural infarct with a central thrombosed artery containing the parasite in stage of degeneration is most commonly seen [ 4 - 6 ] . in the rep...	dirofilariasis is a rare disease in humans . we report here a case of a 48-year - old male who was diagnosed with pulmonary dirofilariasis in korea . on chest radiographs , a coin lesion of 1 cm in diameter was shown . although it looked like a benign inflammatory nodule , malignancy could not be excluded . so , the no...
[ "a 5-year clinical study demonstrated the clinical success of 2sis.24 the purpose of this study was to compare the stress distribution of various types of 2sis that were installed and restored in severely atrophied maxillary molar sites . the 2si approach is a minimally invasive procedure that solely utilizes resid...	purposethe aim of this study was to investigate the stress distribution of 2-short implants ( 2sis ) installed in a severely atrophic maxillary molar site.materials and methodsthree different diameters of internal connection implants were modeled : narrow platform ( np ) , regular platform ( rp ) , and wide platform ( ...
[ "the aim of this retrospective study was to investigate the skeletal manifestations of hydatid disease in serbia , it 's demographic distribution , site involvement , complications , and bone tissue comorbidities . hydatid disease ( echionococcosis ; hydatidosis ) is a parasitic disease , endemic in many sheep rais...	although serbia is recognized as an endemic country for echinococcosis , no information about precise incidence in humans has been available . the aim of this study was to investigate the skeletal manifestations of hydatid disease in serbia . this retrospective study was conducted by reviewing the medical database of i...
[ "this may lead to adverse health effects in workers ; therefore , the government has implemented regulations to protect worker health , such as the occupational safety and health ( osh ) act . based on the employment contract , every employer has a certain amount of control / power and the expectation that workers ...	the management system of occupational diseases in korea can be assessed from the perspective of a surveillance system . workers ' compensation insurance reports are used to produce official statistics on occupational diseases in korea . national working conditions surveys are used to monitor the magnitude of work - rel...
[ "a cross - sectional retrospective study was carried out according to world health organization guidelines over 6 months and included 197 general practitioners ( gps ) and 19,700 prescriptions.this study revealed that the overall index of rational drug prescribing ( irdp ) indicator for gps was below the optimal p...	backgroundthe appropriate use of medicines is essential for the provision of quality health services , patient safety , and the rational use of health resources . in sudan , general practitioners ( gps ) provide 80 % of insured patients health services . pharmaceutical service costs have been increasing since 2010.obj...
[ "blunt traumatic infrarenal aortic injuries are rare , with a few case reports in the literature . this article presents the case of a young woman found to have an intimal flap in the infrarenal abdominal aorta after a car accident , and the injury progressed to a pseudoaneurysm over 3 months .", "a 47-year - old...	blunt traumatic infrarenal aortic injuries are unusual , and the formation of a delayed pseudoaneurysm of the aorta is even more rare . in this report , a young woman developed a small intimal flap of the infrarenal aorta after a motor vehicle accident which progressed into a 3 cm pseudoaneurysm after 3 months . opera...
[ "strains carrying proa - tev - rpt1 were grown in 6 l of sd medium to od600 0.8 to 1.2 . bp1 was then released from the resin by incubating with actev protease ( invitrogen ) at 2.5 unit / l culture in proteasome buffer containing 2 mm atp and protease inhibitors for 1 hr at 30c . resins were collected at 900 g fo...	substrates of the proteasome are recognized and unfolded by the regulatory particle ( rp ) , then translocated into the core particle ( cp ) to be degraded1 . a hetero - hexameric atpase ring , containing subunits rpt1-rpt6 , is situated within the base subassembly of the rp1 . the atpase ring sits atop the cp , with t...
[ "worldwide , head injury is the single largest cause of death and disability following an injury . most patients with severe traumatic brain injuries ( tbi ) in developing countries are discharged to home - based care due to lack of rehabilitative facilities and health insurance . however , resources have not been ...	introduction : it is well - known that severe traumatic brain injuries ( tbi ) have a poor outcome . however , what is not well - known is the outcome for those who survive but remain unconscious at the time of discharge from the hospital.aims and objectives : to assess the outcome of severe tbi patients who have a mot...
[ "the current paper reviews the characteristics and health benefit of highly marbled beef from wagyu and hanwoo cattle . in fact , meat has played a crucial role in human evolution of a healthy and well balanced diet ( pereira and vicente , 2013 ) . their marbling has been increased over many decades to meet domesti...	this review addresses the characteristics and health benefit of highly marbled wagyu and hanwoo beef . marbling of wagyu and hanwoo beef has been increased in japan and korea to meet domestic consumer preferences . wagyu and hanwoo cattle have high potential of accumulating intramuscular fat ( imf ) and producing highl...
[ "the fe(ii ) complex with tptz has a twice higher molar absorptivity coefficient ( 2.2 10 l mol cm ) than the fe(ii ) complex with 1,10-phenanthroline ( 1.1 10 l mol cm ) . we report a simple and cost - effective spectrophotometric method for the reliable analysis of nac and mpg in pharmaceutical formulatio...	a simple spectrophotometric method for the determination of n - acetyl - l - cysteine ( nac ) and n-(2-mercaptopropionyl)glycine ( mpg ) in pharmaceutical preparations was developed , validated , and used . the proposed equilibrium method is based on a coupled two - step redox and complexation reaction . in the fir...
[ "management of arteriovenous malformations ( avms ) remains challenging because of their unpredictable behavior and high recurrence rate if treated by curettage alone without inadequate ligation of the feeder vessels . we present our experience in treating palatal vascular malformation using direct ethanol scleroth...	arteriovenous malformation is treated by variety of techniques over the years . sclerotherapy is considered an effective and conservative technique for the treatment of benign vascular lesions and replaced the traditional role of surgical therapy , especially for the venous lesions that are surgically difficult or at i...
[ "the aim of this study was to characterize the risk factors for development of rickets in elbw infants fed with high mineral containing preterm formula . however , it is often practically difficult to achieve ideal nutrition support in sick elbw infants , the current incidence of rickets in elbw infants is unknown ...	risk factors for rickets of prematurity have not been re - examined since introduction of high mineral formula , particularly in elbw infants . we analyzed the incidence and the risk factors of rickets in extremely low birth weight ( elbw ) infants . as a retrospective case - control study from 2004 to 2008 , risk fact...
[ "kyphosis is a progressive curvature of the thoracic spine , which results in rounding or bowing of the back . a curved spine accompanied by restricted neck motion and poor lung reserve present challenges for an ophthalmic surgeon , who is used to patients neck and head resting flat on the operating table and the e...	we describe a 49-year - old man with advanced kyphosis and dense cataract , who could only recline to about 40 from the vertical axis despite a maximal reverse trendelenburg position and pillows under the head , neck , shoulders and knees . with a single corneal retraction suture at 6 o'clock , the eye could be rotated...
[ "we have also shown that bis- and tris ( indolyl)alkanes can be synthesized in presence of bronsted acid in water . in continuation of our research in hydrated media , herein , we wish to disclose the dual catalytic activity of the system i2-sds - h2o which behaves as a lewis acid for the cleavage of 2,3-diaza-1,...	a novel catalytic system consisting of i2-sds - h2o has been developed which cleaves 2,3-diaza-1,3-butadiene , 1-aza-1,3-butadienes , oximes and in presence of indoles in the medium uses the corresponding aldehyde products to produce bis(indolyl)alkanes in situ . this one pot simple and mild dual catalytic system works...
[ "parental drug misuse and its effects on children and families are policy priorities in the uk and elsewhere ( flavin & paltrow , 2010 ; hm government , 2010 ) . polydrug use is the norm among drug users in the uk , and benzodiazepine use is common ( bird & robertson , 2011 ; department of health ( england ) , 2007...	aimsto explore the ways in which opioid - dependent parents accounted for their use of opioids and benzodiazepines during and after pregnancy.methodslongitudinal qualitative interviews [ n = 45 ] with 19 opioid - dependent adults recruited in scotland , uk , were held during the antenatal and post - natal period . in...
[ "the aim of this study was to explore the vascular and cardiac changes of opg and trail in experimental models of dyslipidemia and diabetes . epidemiological studies have shown that there is an association between circulating opg , trail , and cvd . , we hypothesized that dyslipidemia and diabetes , which are two w...	background . dyslipidemia and diabetes are two of the most well established risk factors for the development of cardiovascular disease ( cvd ) . both of them usually activate a complex range of pathogenic pathways leading to organ damage . here we hypothesized that dyslipidemia and diabetes could affect osteoprotegerin...
[ "compounds 14 , 7 , 8 , and 11 were \n synthesized following our previously reported synthetic routes . these data indicate that the three - dimensional molecular \n shape of ( )-palmyrolide a was crucial for the interaction \n with vgscs . in order to support these observations and to better \n , we examined \n th...	a small library of synthetic ( )-palmyrolide a diastereomers , analogues , and acyclic precursors have been examined with respect to their interaction with voltage - gated sodium channels ( vgscs ) . toward this goal , the ability of ( )-palmyrolide a and analogues to antagonize veratridine - stimulated na+ i...
[ "the online version of this article ( doi:10.1007/s00414 - 009 - 0352 - 9 ) contains supplementary material , which is available to authorized users .", "if a comparable relationship exists between humans and their skin microbiota , as has been observed for h. pylori , new methods for human geographic origin dete...	human fingertip microflora is transferred to touched objects and may provide forensically relevant information on individual hosts , such as on geographic origins , if endogenous microbial skin species / strains would be retrievable from physical fingerprints and would carry geographically restricted dna diversity . we...
[ "carlucci and colleagues have recently studied patient - ventilator interactions in 69 acutely ill patients receiving non - invasive ventilation ( niv ) for a variety of reasons . this study is important as it underscores that patient - ventilator trigger dys - synchrony is common and can be a major barrier to ...	patient - ventilator trigger dys - synchronies are common with the use of assisted forms of mechanical ventilatory support , including non - invasive mechanical ventilatory support ( niv ) . future system designs need to address this in order to improve the effectiveness of niv .
[ "we report a case of predominantly external jugular vein ( ejv ) involvement in an adolescent male with negative blood culture results . postanginal septicaemia in the early 20 century ; originally associated with a mortality reaching 90% it involves a classic triad of oropahryngeal sepsis , internal jugular vein (...	oropharyngeal infections are routinely encountered within general practice and accident and emergency departments . most settle with simple analgesia and antibiotics ; occasionally such patients may develop lemierre s syndrome ( ls ) a rare and potentially fatal sequela that can be easily overlooked . we aim to highlig...
[ "helicobacter pylori is a gram - negative , spiral and microaerophilic microorganism that was first isolated from the stomach of patients afflicted with peptic ulcer ( 1 , 2 ) . it is suspected that gastroesophageal reflux is involved in the pathogenesis of chronic otitis media . evidence showed that stomach pepsin...	background : tympanosclerosis is a condition caused by calcification of tissues in the middle ear mucosa that sometimes results hearing loss . helicobacter pylori is one of the pathological and etiologic factors in the development of tympanosclerosis.objectives:the purpose of this study was to show the role of h. pylor...
[ "the goal of this paper is to provide a modern review of the literature thoroughly analyzing the efficacy of gkrs in the treatment of patients with tn , as well as evaluating the treatment planning and methods associated with this evolving modality . trigeminal neuralgia ( tn ) is a disorder of cranial nerve ( cn )...	since its introduction by leksell , gamma knife radiosurgery ( gkrs ) has become increasingly popular as a management approach for patients diagnosed with trigeminal neuralgia ( tn ) . for this reason , we performed a modern review of the literature analyzing the efficacy of gkrs in the treatment of patients who suffer...
[ "a 55-year - old caucasian female was undergoing elective coronary artery bypass surgery following a recent myocardial infarction . approximately 20 minutes after endoscopic vein harvesting started , we noticed the patient 's end - tidal co2 ( etco2 ) had increased from 36 to 44 mmhg followed by increasing pulmonar...	a carbon dioxide ( co2 ) embolism during endoscopic vein harvesting is a rare but potentially fatal complication . early and accurate diagnosis is crucial for limiting the extent of the embolism and stabilizing the resulting cardiovascular compromise . we report a case of co2 embolization during endoscopic vein harvest...
[ "rather than simply signaling the general presence of termites or providing a diagnosis of the species of termite inhabiting the wood , we postulated that these pellets could be chemically characterized so as to determine the status of a colony as active ( alive ) or inactive ( dead ) . here , we report quantificat...	hydrocarbon mixtures extracted from fecal pellets of drywood termites are species - specific and can be characterized to identify the termites responsible for damage , even when termites are no longer present or are unable to be recovered easily . in structures infested by drywood termites , it is common to find fecal ...
[ "here , we describe \n field - sea , a considerable improvement over sea , which gives accurate \n free energies of transfer of ions and charged solutes , at no additional \n computational cost and with no degradation of the predictions for \n nonpolar and uncharged polar solutes . in overview , we studied full \n ...	previous work describes a computational solvation model called semi - explicit assembly ( sea ) . the sea water model computes the free energies of solvation of nonpolar and polar solutes in water with good efficiency and accuracy . however , sea gives systematic errors in the solvation free energies of ions ...
[ "healthy and cystic liver tissues were compared and mentioned gst enzyme importance for diagnostic biomarker in hydatid cyst disease . however , the hydatid cyst diagnosis technique is under developing due to specificity and sensitivity problems . in the present study , gst enzyme activity of hydatid cyst protoscol...	abstractbackgroundthe aim of this study was to detect the glutathione s - transferase(gst ) enzyme activity of healthy / cystic liver as a diagnostic biomarker for hydatidosis . in order to compare with liver tissue , the level of the gsts enzyme activity of parasite was also determined.methodsparasites were collected ...
[ "we studied fibrinolytic activity , as measured by tpa and pai-1 activity , and a marker of endothelial dysfunction , as measured by tpa antigen , in a population sample with normal glucose tolerance at baseline and analysed data according to conversion to diabetes or not over nine years of follow - up . the possib...	backgroundimpaired fibrinolysis is found in impaired glucose tolerance and type 2 diabetes , associated with components of the metabolic syndrome . there are no data concerning fibrinolysis in subjects with normal glucose tolerance that convert to diabetes.methodswe studied the activities of tissue plasminogen activato...
[ "recent meta - analyses have used mixed treatment comparisons in which both direct and indirect comparisons were used.11,12 duloxetine , a second - generation norepinephrine reuptake inhibitor that has demonstrated efficacy , safety , and tolerability in patients with mdd,1316 has been the subject of several recent...	backgroundapproved doses of antidepressants in japan are usually lower than those in the usa and european union , but to date meta - analyses comparing antidepressants have all used the higher doses approved in the usa and european union and often have used indirect comparisons . the purpose of this study was to conduc...
[ "this paper sets out to discuss the possibility of supplementing the above - described methods with methodological approaches and concepts from another discipline based in cultural studies , namely medical anthropology ( or medical ethnology ) , and to apply these in the context of a specifically designed form of e...	this paper examines the new teaching concept providing medical care on the fringe of society : participant observation and change in perspectives in the context of the interdisciplinary field of querschnittsbereich 2/q 2 ( the transdisciplinary section under ao , the german regulations for licensed physicians ) that ...
[ "the present study was performed to determine the actual status of infection with foodborne trematodes by recovery of adult flukes from riparian people of saravane and champasak province , lao pdr . the primary goal was to control opisthorchiasis in endemic areas and to reduce the incidence of cholangiocarcinoma in...	in this study , we found that haplorchis taichui , a heterophyid intestinal fluke , is highly prevalent , with heavy worm loads , among riparian people in saravane and champasak province , lao pdr . fecal specimens were collected from 1,460 people ( 717 men and 743 women ) in 12 riparian ( mekong river ) districts and ...
[ "for patients and families , the issue of data quality is personal . when treatment decisions or research conclusions are based on incomplete or inaccurate information a misdiagnosis , an incomplete medication list , the wrong demographic data ", "thanks in part to the power of health information technology , in...	introduction : for patients and families , the issue of data quality is personal . when treatment decisions or research conclusions are based on incomplete or inaccurate information a misdiagnosis , an incomplete medication list , the wrong demographic data care safety , quality , and outcomes suffer and patients an...
[ "adverse drug reactions ( adrs ) , including interactions , in older people are a common cause of admission to hospital1 and are also a common cause of disease in hospitalized patients . frail elderly patients appear to be particularly at risk of adrs . in some cases , this is because insufficient account is taken ...	rhabdomyolysis is a clinical and laboratory syndrome that is caused by various etiologies , involving the skeletal muscle . clarithromycin , like other macrolides , is an inhibitor of cyp450 3a4 , the major enzyme responsible for the metabolism of several drugs , in particular some statins . rhabdomyolysis related to m...
[ "supravalvar mitral ring is a circumferential ridge or membrane arising from the left atrial wall overlying the mitral valve and frequently attached to the mitral valve.1 variable in thickness and extent , the ring ranges from a thin membrane to a thick discrete fibrous ridge.2 the membranous variety may be difficu...	supravalvar mitral ring is a rare congenital heart defect of surgical importance . the condition is characterized by an abnormal ridge of the connective tissue on the atrial side of the mitral valve . it often substantially obstructs the mitral valve inflow . we herein introduce a case of a supravalvar mitral ring in a...
[ "a literature review was carried out in international electronic databases including pubmed , web of sciences , cumulative index to nursing and allied health literature ( cinahl ) , scopus , ebsco , embase and science direct without any time limitation , using the search terms qualitative research , authors of t...	considering the nature of qualitative studies , the interaction between researchers and participants can be ethically challenging for the former , as they are personally involved in different stages of the study . therefore , formulation of specific ethical guidelines in this respect seems to be essential . the present...
[ "there is limited data on the antibiotic resistance of bacteria in fish and other cultured organisms sampled directly from fish farms as well as the aquaculture environment . this sector is challenged with the diverse type of diseases and bacterial infections ; and antibiotics are an excellent tool to circumvent th...	the administration of antimicrobials in aquaculture provides a selective pressure creating a reservoir of multiple resistant bacteria in the cultured fish and shrimps as well as the aquaculture environment . the objective of this study was to determine the extent of antibiotic resistance in aquaculture products and aqu...
[ "with an incidence rate of 0.92% , maternal puerperal lower extremity nerve injuries are rare . lateral femoral cutaneous neuropathy ( meralgia paraesthetica ) is the most common , followed by femoral neuropathy . the presented case involved a 32-year - old woman with bilateral heel numbness due to bilateral neurop...	we describe the case of a 32-year - old woman who developed bilateral heel numbness after obstetric epidural analgesia . we diagnosed her with bilateral neuropathy of the medial calcaneal nerve , most likely due to longstanding pressure on both heels . risk factors for the development of this neuropathy were prolonged ...
[ "the aim of this study was to evaluate , using a conventional pcr assay , the prevalence of mhf and cmhm infections in stray cats from colonies in milan and to identify possible risk factors for these infections . their zoonotic potential has recently been substantiated by the molecular identification of a feline h...	this study investigated the prevalence of feline haemoplasma infections in a number of stray cat colonies in milan , northern italy . blood samples from 260 stray cats were evaluated , with conventional pcr , for the presence of dna associated with mycoplasma haemofelis ( mhf ) and candidatus mycoplasma haemominutum ...
[ "in a case - control study , 140 patients including two equal groups of traumatic due to traffic injuries and non - traumatic patients were evaluated . using the persian version of the conners adult adhd rating scale ( caars ) self - report ( screening version ) the diagnosis of adhd was for children , a rating sca...	objectivenowadays , it is well known that the attention - deficit / hyperactivity disorder ( adhd ) is not confined to children and adolescents . recent data showed that a considerable portion of the general adult population may be affected by adhd . on the other hand , the impact of adhd on driving performance , a maj...
[ "region , the methylation of which is related to tissue specific gene expression . therefore , in the present investigation we have explored the possibility that methylation of the promoter contributes to the control of crh expression in trophoblast cells . crh is a 41-amino - acid peptide hormone synthesized in th...	corticotropin releasing hormone ( crh ) production by the human placenta increases exponentially as pregnancy advances , and the rate of increase predicts gestational length . crh gene expression is regulated by camp in trophoblasts through a cyclic amp - response element ( cre ) , which changes its transcription facto...
[ "these ab initio calculations consist of the following steps : the choosing the model structures , geometry optimization , natural bond orbital analysis ( nbo ) , atoms in molecules analysis ( aim ) , and spectroscopic nmr parameter calculations , which are currently among the most popular methods used for conforma...	lincosamides are a class of antibiotics used both in clinical and veterinary practice for a wide range of pathogens . this group of drugs inhibits the activity of the bacterial ribosome by binding to the 23s rna of the large ribosomal subunit and blocking protein synthesis . currently , three x - ray structures of the ...
[ "initial evaluations suggest that pcmcs can provide timelier assessment , lead to a high degree of satisfaction among referring physicians , patients , and caregivers , and streamline access to specialists . in order to retain the fidelity of such programs and consistency with initial training and practice guidelin...	backgroundprimary care - based memory clinics ( pcmcs ) have been established in several jurisdictions to improve the care for persons with alzheimer s disease and related dementias . we sought to identify key quality indicators ( qis ) , quality improvement mechanisms , and potential barriers and facilitators to the e...
[ "symptomatic supravesical obstructive uropathy in a patient with dual functioning kidneys is classically characterized by bilateral hydroureters / hydronephrosis and an empty urinary bladder . our recent experience with a uraemic 56-year - old caucasian showing only unilateral moderate right - sided hydronephrosis ...	bilateral hydronephrosis is classic for supravesical obstructive uropathy causing uraemia with dual functioning kidneys . recently , a patient presented with uraemia and metastatic urinary bladder carcinoma but only unilateral right - sided hydronephrosis . a right ureteral stent was placed retrograde and no further in...
[ "there are now quite a few programs for mimotope based epitope mapping , none of them , however , has a procedure to scan , report and exclude target - unrelated peptides [ 1523 ] . in this study , we describe a web server named sarotup , which is an acronym for scanner and reporter of target - unrelated peptides ...	as epitope mimics , mimotopes have been widely utilized in the study of epitope prediction and the development of new diagnostics , therapeutics , and vaccines . screening the random peptide libraries constructed with phage display or any other surface display technologies provides an efficient and convenient approach ...
[ "we report an adult who presented with non - specific dizziness and lesions of the scc on magnetic resonance imaging ( mri ) who was diagnosed with hemorrhagic fever with renal failure syndrome ( hfrs ) with serologically proven hantaan virus infection . reversible focal lesions in the splenium of the corpus callos...	this is the first case of virus - associated encephalitis / encephalopathy in which the pathogen was hantaan virus . a 53-yr - old man presented fever , renal failure and a hemorrhagic tendency and he was diagnosed with hemorrhagic fever with renal failure syndrome ( hfrs ) . in the course of his illness , mild neurolo...
[ "we present a case of critical as with significant symptom manifested as chest pain that was managed successfully without surgical avr or tavr . as is the most common cause of left ventricular outflow obstruction in children and adults . it is most common type of valvular heart disease in europe and north america ,...	aortic valve replacement ( avr ) remains the cornerstone of treatment for symptomatic critical aortic stenosis ( as ) . it is a class i indication that symptomatic patients with critical as undergo either surgical or transcatheter aortic valve replacement ( tavr ) . we present a patient with critical as and new angina ...
[ "this paper will discuss progress in utilising novel cellular reprogramming techniques to treat rbc diseases . the various blood cell lineages in mammals arise from a multipotent haematopoietic stem cell via particular differentiation pathways . there are a number of severe diseases caused by the disruption of adul...	haemoglobinopathies such as thalassaemia and sickle cell disease present a major health burden . currently , the main forms of treatment for these diseases are packed red blood cell transfusions and the administration of drugs which act to nonspecifically reactivate the production of foetal haemoglobin . these treatmen...
[ "vasopressin 0.6 iu was quickly administered intravenously , and the transesophageal echocardiography ( tee ) revealed a massive gas floating at the orifice of the rca ( fig . the co2 blower was more aggressively used to aid grafting at a flow rate of 3 - 5 l / min . although the patient remained in normal sinus rh...	although compressed gas ( co2 ) blowers have been used safely to aid accurate grafting during off - pump coronary bypass surgery , hemodynamic collapse due to gas embolism into the right coronary artery may occur . supportive measures to facilitate gas clearance by increasing the coronary perfusion pressure have been r...
[ "multiple sclerosis ( ms ) is a chronic progressive inflammatory and neurodegenerative disease of human central nervous system ( cns ) which usually affects young adults , with a reported median age of onset of approximately 30 years.1 in approximately 85% of patients with ms , the disease is initially recognized b...	multiple sclerosis ( ms ) is a progressive immune - mediated neurodegenerative disease of human central nervous system ( cns ) , which causes irreversible disability in young adults . the cause and cure for ms remain unknown . pathophysiology of ms includes two arms : inflammatory demyelination and neurodegeneration . ...
[ "several imaging modalities including pa , occlusal and panoramic radiography , cone beam computed tomography ( cbct ) and ct are used before and after implant treatment as well as in the maintenance sessions . after successful implant placement , the popularity of digital radiography in dentistry is mainly due to ...	objectives : this study aimed to compare the diagnostic accuracy of inverted and unprocessed digitized periapical radiographs for detection of peri - implant defects.materials and methods : a total of 30 osteotomy sites were prepared in three groups of control , study group 1 with 0.425 mm defects and study group 2 wit...
[ "aorto - esophageal fistula ( aef ) , an abnormal anatomical communication between the aorta and esophagus is a rare cause of ugib . we present a case of aef which was initially treated as variceal bleeding and later promptly diagnosed with computed tomography ( ct ) . upper gastrointestinal bleeding ( ugib ) is a ...	aorto - esophageal fistula is a rare cause of upper gastrointestinal bleeding . thoracic aneurysm , the most common cause of this condition , will slowly increase over time and can erode the wall of the aorta creating a fistula and leading to torrential bleeding . high clinical suspicion is required for timely diagnosi...
[ "we have shown that the pn junction formed by combining p - type and n - type gels together in much closer contact rectifies the current . the discovery of the silicon pn junction is a landmark in the development of modern microelectronics . these semiconductor polymeric gels can be doped with both negative ( n - t...	in this study , we synthesized the new kinds of semiconducting polymeric gels having negative ( n - type ) and positive ( p - type ) counter ions as charge carriers . the polyacrylamide gel was doped with pyranine ( 8-hydroxypyrene-1,3,6-trisulfonic acid , trisodium salt ) , havingions as side groups and na+ as counter...
[ "we decided to continue observing fdg uptake in the mediastinal and peribronchial lymph nodes rather than prescribing chemotherapy , because metastasis of leiomyosarcoma to the lymph nodes is rare . a chest ct scan done 1 year after surgery demonstrated no changes in the pulmonary nodules and no recurrence of the m...	pulmonary benign metastasizing leiomyoma ( pbml ) is defined as metastasis of a leiomyoma to lung tissue . it was first reported in 1937 . p bml is known as a benign disease , but can undergo malignant transformation . only 1 case of the malignant transformation of pbml to leiomyosarcoma has been reported previously . ...
[ "the purpose of this study was to compare these two questionnaires in the general japanese population , as no previous research has done so , as well as to assess the ability of both instruments to discriminate between subjects with and without persistent ao . another copd screening tool , the international primary...	backgroundthe incidence of chronic obstructive pulmonary disease ( copd ) is increasing worldwide . in japan and other countries , epidemiological studies have found that many patients with copd are underdiagnosed and untreated , and thus , early detection and treatment of copd has been emphasized . screening questionn...
[ "the aim of this study was to assess the incidence and risk of acquiring cmv infection in pregnant women in an urban area in northern italy in the period 20052007 . the human cytomegalovirus ( cmv ) or human herpesvirus 5 is one of the major causes of congenital infections . as far as prevention is concerned , in a...	the fetal consequences of cmv infection make it one of the most serious infections contracted during pregnancy , but the scientific community is divided over the proposed implementation of preventive screening for anti - cmv antibodies . the aim of this study was to assess the incidence and risk of infection during pre...
[ "when considering a patient 's prognosis with nmibc , it is necessary to consider not only clinical and pathological factors but also take into account the potential effect of the intravesical treatment received and molecular alterations present in the tumors . bladder cancer is the second most commonly diagnosed g...	introduction : non - muscle invasive bladder cancer ( nmibc ) comprises about 70% of all newly diagnosed bladder cancer , and includes tumors with stage ta , t1 and carcinoma in situ ( cis . ) since , nmibc patients with progression to muscle - invasive disease tend to have worse prognosis than with patients with prima...
[ "three publicly available data sets of interest in this paper are pediatric acute myeloid leukemia ( aml ) , b - cell chronic lymphocytic leukemia ( b - cll ) , and primary cutaneous melanoma . given that differences in the biology of lung cancer and other diseases exist between men and women [ 14 , 15 ] , investig...	numerous studies have demonstrated sex differences in drug reactions to the same drug treatment , steering away from the traditional view of one - size - fits - all medicine . a premise of this study is that the sex of a patient influences difference in disease characteristics and risk factors . in this study , we inte...
[ "we have applied a duplex - nested pcr for the amplification of both the causative mutation and the y chromosome specific sry gene , and fish for aneuploidy screening of chromosome x , y and 18 . , we describe the successful pregnancy and birth after pgd for otc deficiency with simultaneous analyses of fish and dup...	ornithine transcarbamylase ( otc ) deficiency is an x - linked co - dominant disorder . a couple , with a previous history of a neonatal death and a therapeutical termination due to otc deficiency , was referred to our center for preimplantation genetic diagnosis ( pgd ) . the female partner has a nonsense mutation in ...
[ "therefore , we investigated \n the effects of an unstable inclined board on the active and passive ankle rom in patients \n with ankle stiffness . studies have reported that balance - training \n programs that alter the somatosensory input , such as the use of an unstable surface to \n induce equalized weight dist...	[ purpose ] the present study assessed the effects of using an unstable inclined board on the active and passive ankle range of motion in patients with ankle stiffness . [ subjects ] the study included 10 young female patients with ankle stiffness . [ methods ] the patients were divided into the following two gro...
[ ", we describe a case a young female with ss who presented with features of gitelman syndrome and hypokalemic paralysis . renal tubular involvement in sjgren 's syndrome ( ss ) usually manifests with fanconi syndrome , distal ( type 1 ) renal tubular acidosis ( rta ) , nephrogenic diabetes insipidus , and hypokalem...	we report a case of a young female patient who presented with weakness of upper and lower limbs . on evaluation , she had hypokalemia , hypomagnesemia , metabolic alkalosis and hypocalciuria . anti - ro ( ssa ) antibody was positive . she had an acquired gitelman syndrome due to primary sjgren 's syndrome ( ss ) . ss p...
[ "inadequate organization has been identified as an important cause of inappropriate courses of treatment for patients in the health care system [ 1 , 2 ] . a response to this challenge has been to focus on integrated health care and co - ordination between the actors involved in the process [ 37 ] . the aim of this...	objectivesthe aim of follow - up visits by the general practitioner and district nurse ( within a week after discharge from hospital ) is to reduce hospital readmissions and improve the overall wellbeing of the patient . there is strong evidence that these programmes are effective , but are difficult to implement becau...
[ "alzheimer s disease ( ad ) is a progressive neurodegenerative disorder starting with mild memory loss and manifesting in severe cognitive decline . our discussion presented here attempts to integrate two major factors that are associated with neurodegeneration , protein homeostasis and aging . today , we know that...	alzheimer s disease ( ad ) is one key medical challenge of the aging society and despite a great amount of effort and a huge collection of acquired data on molecular mechanisms that are associated with the onset and progression of this devastating disorder , no causal therapy is in sight . the two main hypotheses of ad...
[ "we intended to study this effect and analyze if teriparatide can be an effective adjunct therapy to achieve solid posterolateral fusion mass and reduce the incidence of subsequent screw loosening after multilevel instrumented lumbar fusion surgeries in elderly patients . its action as a direct anabolic agent in bo...	abstractelderly patients with chronic nonresolving symptoms due to degenerative spine pathologies are prone to have poor surgical outcomes and hardware - related complications , especially following multilevel instrumented lumbar fusion surgeries . with intention of analyzing if teriparatide can be an effective adjunct...
[ "this study aims to establish the prevalence of hypertension , diabetes , obesity , and metabolic syndrome in the participants of a major health screening programme in nepal . metabolic syndrome ( ms ) is a constellation of overweight / obesity , hypertension , and disturbances of lipid and carbohydrate metabolism ...	background . this study was carried out to establish the prevalence of cardiovascular risks such as hypertension , obesity , and diabetes in eastern nepal . this study also establishes the prevalence of metabolic syndrome ( ms ) and its relationships to these cardiovascular risk factors and lifestyle . methods . 14,425...
[ "hence , simulator \n horseback riding exercise equipment using virtual reality has been developed for use at home \n and in small spaces . horseback riding exercise is one such therapy . in research conducted by arajo et al . as balance ability and falls are closely related in the elderly , exercise therapies need...	[ purpose ] the aim of this study was to examine the effects of horse - riding simulator exercise on balance in elderly with knee osteoarthritis . [ subjects and methods ] fifty elderly patients with knee osteoarthritis were recruited , a horse - riding simulator group performed exercise three times a week for ei...
[ "we focus on shh medulloblastoma and discuss how cell senescence shapes the natural history and molecular evolution of this childhood cancer . are characterized by activation of the hedgehog ( hh ) signaling pathway and are often driven by mutations in hh pathway components . here , medulloblastomas can be classifi...	abstractthe mechanisms leading to brain tumor formation are poorly understood . using ptch1+/ mice as a medulloblastoma model , sequential mutations were found to shape tumor evolution . initially , medulloblastoma preneoplastic lesions display loss of heterozygosity of the ptch1 wild - type allele , an event associate...
[ "the clinical working diagnosis was pregnancy - related vt of right ventricular outflow tract origin . a 33-year - old woman , ( gravida 3 , para 2 ) , at 34 weeks of gestation , presented with episodes of lightheadedness , and dyspnea . she was asymptomatic until 18 weeks of gestation , when she started having epi...	ventricular tachycardia although not common , can occasionally complicate pregnancy . its presence may indicate an underlying cardiac structural abnormality , or undiagnosed congenital arrhythmic disease . however , some pregnant patients with ventricular tachycardia have structurally normal hearts . two cases of ventr...
[ "the aim of this study was to investigate system - wide changes in protein expression during growth on dibenzofuran , a nontoxic surrogate for dibenzo - p - dioxin , as compared to nonselective growth media . thus , any changes measured in response to cells grown on dibenzofuran should represent cell - wide effects...	sphingomonas wittichii rw1 is a bacterium of interest due to its ability to degrade polychlorinated dioxins , which represent priority pollutants in the usa and worldwide . although its genome has been fully sequenced , many questions exist regarding changes in protein expression of s. wittichii rw1 in response to diox...
[ "we compare , for the first time , a novel ba formulation ( containing bosexil , inci : lecithin , bse ) with a placebo formulation in the treatment of psoriasis or eczema . a third arm of the trial received a formulation of vaccinium myrtillus seed oil , which was previously demonstrated as an efficient local trea...	backgroundboswellic acids ( bas ) show anti - inflammatory properties in a variety of inflammatory diseases , including rheumatoid arthritis , osteoarthritis , and asthma . a topical administration route is currently used to deliver active compounds in psoriatic and eczematous patients . in this double - blind study we...
[ "the fragment was confirmed by sequencing and ligated to the ecori and bamhi \n sites of the peyfp - c1 vector to give the in - frame fusion gene . the binding to each protein was visualized using a select western blotting detection system \n ( ge healthcare bio - sci . local dna damage induction using laser and ce...	clinically , many chemotherapeutics and ionizing radiation ( ir ) have been applied for the treatment of various types of human and animal malignancies . these treatments kill tumor cells by causing dna double - strand breaks ( dsbs ) . core factors of classical nonhomologous dna - end joining ( c - nhej ) play a...
[ "our results showed that the uptake of folic - acid modified nanoparticles by 5rp7 cancer cells was also much higher than that of 3t3 cells . this modification can be used for successful targeting of cancer cells expressing the folate receptor . folic acid modification of magnetic nanoparticles could be used to fac...	background : magnetic nanoparticles show great promise for use as tools in a wide variety of biomedical applications . the purpose of this study was to investigate the potential effects of methacrylamido - folic acid ( ma - fol)-modified magnetic nanoparticles on 5rp7 ( h - ras - transformed rat embryonic fibroblasts )...
[ "on the basis of the collected data , participants were dichotomized into those with or without lbp , while indicating the sports discipline in which they were injured or that they were injured after cumulative fatigue due to the large number of hours spent in practicing sports and physical activities . in 1 week ,...	introductionfor obvious reasons , athletes are at greater risk of sustaining a lumber ( lower ) spine injury due to physical activity . to our knowledge , no previous studies have examined the prevalence of low back pain ( lbp ) in a tunisian sports and physical education institute.aimto assess the prevalence of lbp in...
[ "therefore , this study explored the meaning of health as perceived by iranian kurdish diabetic patients in order to develop an appropriate multidisciplinary outlook toward this ethnicity of patients . prior studies have shown lack of awareness about the concept of health among iranian kurdish diabetic patients . a...	introductionhealth is an exclusive and subjective phenomenon , and one of the most important situations with regard to perception of health , arises when patients suffer from a chronic disease.this study was conducted within the qualitative research framework and aimed to explore the meanings of health as perceived by ...
[ ", we try to clarify this topic from the perspective of avicenna and traditional persian medicine ( tpm ) . however , proper amount of daily water intake in a healthy individual is controversial . there is a prevalent thought that we all have to drink eight glasses of water daily", "furthermore , medline , embase...	background : fluid intake is an essential factor in having a normal homeostasis . however , proper amount of daily water intake in a healthy individual is controversial . there is a prevalent thought that we all have to drink eight glasses of water daily , however , it lacks enough supportive evidence at least for heal...
[ "it was visually noted that subcutaneous fat in the abdominal region was still present , despite severe losses in the peripheral limbs , protruding ribs , and lack of prominent chest and shoulder musculature . a 34year - old male presented for general examination on day 49 of a 50-day self - imposed fast , seeking ...	a 34-year - old obese male ( 96.8 kg ; bmi , 30.2 kg m1 ) volitionally undertook a 50-day fast with the stated goal of losing body mass . during this time , only tea , coffee , water , and a daily multivitamin were consumed . severe and linear loss of body mass is recorded during these 50 days ( final 75.4 kg ; bmi , 2...
[ "one of the important developments in the surgical approach is peeling of the internal limiting membrane ( ilm ) . tangential tractions on the vitreomacular interface are usually responsible for the development of idiopathic macular holes . the most difficult aspect of surgery is due to the tight attachment of the ...	purpose : the evaluation of anatomic and visual outcomes in macular hole cases treated with internal limiting membrane ( ilm ) peeling , brilliant blue ( bb ) , and 23-gauge pars plana vitrectomy ( ppv).materials and methods : fifty eyes of 48 patients who presented between july 2007 and december 2009 with the diagnosi...
[ "a total of 339 white patients with type 2 diabetes who had survived an mi were studied . the study included 340 whites from italy with type 2 diabetes ( according to american diabetes association 2003 criteria ) and coronary artery disease ( cad ) , as indicated by previous myocardial infarction ( mi ) or > 50% st...	objectiveinsulin resistance ( ir ) and cardiovascular disease may share a common genetic background . we investigated the role of ir - associated enpp1 k121q polymorphism ( rs1044498 ) on cardiovascular disease in high - risk individuals.research design and methodsa prospective study ( average follow - up , 37 months )...
[ "also , recent data support the combined roles of protein - coding genes and non - coding rnas , such as micrornas , in the pathogenesis of frequent diseases ( such as cancer , immune and cardiac disorders ) . the authors developed a modular device composed of a sensor ( an aptamer ) and a gene - regulatory compo...	synthetic rna - based regulatory systems are used to program higher - level biological functions that could be exploited , among many applications , for in vivo diagnostic and therapeutic applications . chen and colleagues have recently reported a significant technological advance by producing an rna modular device bas...
[ ", we present two cases of idms with different wt1 gene mutations that had previously been reported in association with dds . the nephropathies in dds are characterized by the histological finding of diffuse mesangial sclerosis ( dms ) , a finding also described in some cases of congenital nephrotic syndrome ( isol...	here we report two cases of isolated diffuse mesangial sclerosis ( idms ) with early onset end - stage renal failure . these female patients did not show abnormalities of the gonads or external genitalia . direct sequencing of wt1 pcr products from genomic dna identified wt1 mutations in exons 8 ( 366 arg > his ) and 9...
[ "the aim of present study was to derive a phototoxicity ratio between the results of the nanotio2 experiments conducted in the absence of sunlight and conducted in the presence of solar or simulated solar radiation ( ssr ) . to achieve this aim , we searched the literature for studies that included nanotio2 experim...	abstracttitanium dioxide nanoparticles are photoactive and produce reactive oxygen species under natural sunlight . reactive oxygen species can be detrimental to many organisms , causing oxidative damage , cell injury , and death . most studies investigating tio2 nanoparticle toxicity did not consider photoactivation a...
[ "we report 2 patients infected with panton - valentine leukocidin ( pvl)positive mrsa t034 . each patient had a medical history typical of that reported for community - acquired mrsa of other lineages , which in most cases are pvl positive ( 8) . the first patient , a previously healthy 36-year - old male physiothe...	panton - valentine leukocidin ( pvl)positive methicillin - resistant staphylococcus aureus ( mrsa ) , sequence type 398 is believed to be of animal origin . we report 2 cases of infection due to pvl positive mrsa , spa type t034 , in patients in sweden who had had no animal contact .
[ "the selective melatonin receptor agonism effect of ramelteon is useful for insomnia.1 ) here we wanted to present a refractory chronic migraine case , who had significant improvements in migraine after using ramelteon .", "the precipitating factors were the stress , increase in physical activities and sudden col...	the selective melatonin receptor agonism effect of ramelteon is useful for insomnia . here we wanted to present a refractory chronic migraine case , who had significant improvements in migraine after using ramelteon . the possible mechanism for the ramelteon in the migraine relief might be related to melatonin effects ...
[ "therefore , our study was aimed to determine is levels and three different types of antioxidant enzyme activities gsh - px , gr , and sod , in t2d with ati and li . , oxidative stress can be an important component for astrocytic cell death following metabolic stress . until now , experimental studies provided ev...	we analyzed ( a ) insulin sensitivity ( is ) and ( b ) glutathione peroxidase ( gsh - px ) , glutathione reductase ( gr ) , and superoxide dismutase ( sod ) antioxidant enzyme activity in type 2 diabetic ( t2d ) patients with atherothrombotic infarction ( ati ) ( group a ) , lacunar infarction ( li ) ( b ) , or without...
[ "in particular , we were interested in the differentiation between different types of soil such as grasslands ( pasture , meadow ) , allotment gardens , and forests , as well as fluvial sediments , the relationship of soil parameters ( carbon - to - nitrogen ratio ) on the occurrence of bacterial spores , and the d...	spore formation is a survival mechanism of microorganisms when facing unfavorable environmental conditions resulting in dormant states . we investigated the occurrence of bacterial endospores in soils from various locations including grasslands ( pasture , meadow ) , allotment gardens , and forests , as well as fluvi...
[ ", we investigated the time - ordered changes of pro - apoptotic and anti - apoptotic factors to determine the role of the upr signaling pathway in cognitive decline of 5fad mice alzheimer 's disease ( ad ) is a common neurodegenerative disease in the central nervous system . many studies have shown that ers is inv...	background : amyloid ( a ) deposits and the endoplasmic reticulum stress ( ers ) are both well established in the development and progression of alzheimer 's disease ( ad ) . however , the mechanism and role of a-induced ers in ad - associated pathological progression remain to be elucidated.methods:the five familial ...
[ "thus , in this study , we aimed at identifying ip in symptomatic multivessel cad patients and compared the results among patients with and without type 2 dm . ischemic heart disease is the most frequent [ 5 , 6 ] and is associated with the highest morbidity and mortality in patients with type 2 dm . despite the ad...	backgroundthe influence of diabetes mellitus on myocardial ischemic preconditioning is not clearly defined . experimental studies are conflicting and human studies are scarce and inconclusive.objectivesidentify whether diabetes mellitus intervenes on ischemic preconditioning in symptomatic coronary artery disease patie...
[ "most malignant heart tumors are sarcomas : myxosarcoma , liposarcoma , angiosarcoma , fibrosarcoma , leiomyosarcoma , osteosarcoma , synovial sarcoma , rhabdomyosarcoma , undifferentiated sarcoma , reticulum cell sarcoma , neurofibrosarcoma , and malignant fibrous histiocytoma . arrhythmias can develop from intraa...	backgroundtotal artificial heart ( tah ) implantation in patients with aggressive tumor infiltration of the heart can be challenging.case reportwe report on a patient with a rare primary undifferentiated high - grade spindle cell sarcoma of the mitral valve and in the left atrium , first diagnosed in 2014 . the referri...
[ "as we watch the effects of the legalization of cannabis in colorado , washington , alaska , oregon , and the district of columbia , other jurisdictions are debating the future of this illicit drug . cannabis is a prominent political , health , and law enforcement issue in north america that is currently receiving ...	cannabis is the most commonly used illicit substance among youth . recent policy developments and ongoing debate related to this drug underscore the urgent need to clear the smoke and better understand what the scientific evidence says about the health and behavioral effects of cannabis use , particularly on youth wh...
[ "hypertension and its sequelae , heart failure ( hf ) , are a progressive disease . hypertension ( htn ) is the most common comorbidity in the world with significant public health implications [ 1 , 2 ] . the overall u.s . heart failure in comparison to the most prevalent gender malignancies ( bowel cancer in m...	hypertension ( htn ) is the most common co - morbidity in the world , and its sequelae , heart failure ( hf ) is one of most common causes of mortality and morbidity in the world . current understanding of pathophysiology and management of htn in hf is mainly based on studies , which have mainly included whites . among...
[ "radiological investigations and therapeutics have become an integral part of the management of critically ill patients in the intensive care unit ( icu ) . we , therefore , carried out this study to determine the total radiation exposure to icu resident doctors involved in the course of their duties . the conclusi...	background and aims : with the expanding use of diagnostic and therapeutic radiological modalities in critically ill patients , doctors working in intensive care units ( icus ) are increasingly exposed to ionizing radiation . this risk of radiation exposure occurs not only during bedside radiologic procedures , but als...
[ "this is largely to blame on lack of access to viral load quantification , because this is considered a mandatory component of the diagnostic work - up in all international liver society guidelines . without a viral load measurement , despite the huge burden of hepatitis b worldwide , with an estimated 350 million ...	viral hepatitis claims one million lives each year . scaling up treatment for hepatitis b and c in resource - limited settings is not possible without access to reliable diagnostic tools . this article gives an overview of current technologies and the pipeline for easy - to - use assays for serological and virological ...

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