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Bloody Gust | The first 6 times Isaac takes damage on a given floor, he gains Speed and Fire Rate for the rest of the floor, up to a maximum of +1.02 and +3.00, respectively. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/f3/Collectible_Bloody_Gust_icon.png/revision/latest?cb=20210824092826 | |
Salvation | Gives Isaac a halo that summons beams of light on enemies inside it. The halo grows larger the more times Isaac has taken damage this floor. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/56/Collectible_Salvation_icon.png/revision/latest?cb=20210824092805 | |
Vanishing Twin | Spawns a familiar that becomes a weaker clone of the floor's boss when entering the Boss Room. Defeating it drops an extra item. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/58/Collectible_Vanishing_Twin_icon.png/revision/latest?cb=20210824092745 | |
Twisted Pair | Spawns two familiars that float on either side of Isaac and fire tears that use his tears, range, shot speed, and tear effects, and scale with damage. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/3c/Collectible_Twisted_Pair_icon.png/revision/latest?cb=20210824092724 | |
Azazel's Rage | Isaac builds rage every time a room is cleared. After four rooms, fires a large Brimstone laser when entering the next room. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/ac/Collectible_Azazel%27s_Rage_icon.png/revision/latest?cb=20210824092702 | |
Echo Chamber | When Isaac uses a Card, Pill, or Rune, he also uses a copy of the previous three Cards/Pills/Runes he used after picking up Echo Chamber. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/f4/Collectible_Echo_Chamber_icon.png/revision/latest?cb=20210824092641 | |
Isaac's Tomb | Spawns an Old Chest at the start of each floor. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/96/Collectible_Isaac%27s_Tomb_icon.png/revision/latest?cb=20210824092620 | |
Vengeful Spirit | After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/0b/Collectible_Vengeful_Spirit_icon.png/revision/latest?cb=20210824092538 | |
Supper | Grants one full Red Heart container. Heals 1 additional Red Heart. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/6d/Collectible_Supper_icon.png/revision/latest?cb=20210824092517 | |
Stapler | +1 Damage. Prevents Isaac from firing tears from his left eye, like Cain. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/16/Collectible_Stapler_icon.png/revision/latest?cb=20210824092455 | |
Keeper's Sack | Gives range, speed, or damage when buying things from a shop. Also spawns three coins and a Key on pickup. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/41/Collectible_Keeper%27s_Sack_icon.png/revision/latest?cb=20211111110832 | |
Keeper's Kin | Rocks and other Obstacles spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/7d/Collectible_Keeper%27s_Kin_icon.png/revision/latest?cb=20210824092412 | |
TMTRAINER | Causes all future items to be "glitched", granting them completely random effects. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/62/Collectible_TMTRAINER_icon.png/revision/latest?cb=20210824092350 | |
Hypercoagulation | After Isaac takes damage from an enemy or donates health, launches Red Hearts from Isaac that despawn after 1.5 seconds. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/7f/Collectible_Hypercoagulation_icon.png/revision/latest?cb=20210824092329 | |
IBS | Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/cb/Collectible_IBS_icon.png/revision/latest?cb=20210824092308 | |
Hemoptysis | Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him. Affected enemies are cursed and take more damage from Brimstone-like attacks. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/8f/Collectible_Hemoptysis_icon.png/revision/latest?cb=20210824092248 | |
Ghost Bombs | +5 Bombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/0f/Collectible_Ghost_Bombs_icon.png/revision/latest?cb=20210824092227 | |
Glass Eye | +0.75 damage, +1 luck. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/09/Collectible_Glass_Eye_icon.png/revision/latest?cb=20211111111506 | |
Stye | Tears fired from Isaac's right eye have +28% Damage, +6.5 Range, and -0.3 Shot Speed. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/eb/Collectible_Stye_icon.png/revision/latest?cb=20211111111526 | |
Mom's Ring | +1 Damage. Drops a random Rune or Soul Stone upon pickup. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/6f/Collectible_Mom%27s_Ring_icon.png/revision/latest?cb=20211111111546 |
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