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Almond Milk | Quadruples fire rate, with ×0.3 damage multiplier. Each tear is given a random effect that alters its movement. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/2a/Collectible_Almond_Milk_icon.png/revision/latest?cb=20210822150735 | |
Rock Bottom | Locks Isaac's attributes to their highest values reached. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a5/Collectible_Rock_Bottom_icon.png/revision/latest?cb=20210824100112 | |
Nancy Bombs | +5 Bombs. Each bomb gains 1-4 random bomb synergies. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/80/Collectible_Nancy_Bombs_icon.png/revision/latest?cb=20210824100051 | |
A Bar of Soap | +0.5 Tears, +0.2 Shot Speed. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/c0/Collectible_A_Bar_of_Soap_icon.png/revision/latest?cb=20210822150139 | |
Blood Puppy | Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac, it will also generate Half Red Hearts on enemy kills. It can increase in power one more stage after killing even more enemies. Dealing enough damage to it returns it to normal. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/78/Collectible_Blood_Puppy_icon.png/revision/latest?cb=20210824095947 | |
Dream Catcher | During the transition between floors, Isaac's nightmare shows the contents of the upcoming floor's Treasure Room, as well as the floor's boss. Grants a Half Soul Heart when entering a new floor. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/85/Collectible_Dream_Catcher_icon.png/revision/latest?cb=20210824093531 | |
Paschal Candle | Gives Isaac a familiar that grants +0.4 Fire Rate for each consecutive room he's cleared without taking damage. The bonus stacks up to five times. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/72/Collectible_Paschal_Candle_icon.png/revision/latest?cb=20210824100030 | |
Divine Intervention | Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/86/Collectible_Divine_Intervention_icon.png/revision/latest?cb=20210824100009 | |
Blood Oath | Stabs Isaac at the beginning of each floor, draining his Red Hearts. Increases damage and speed for the floor based on the amount drained. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/7e/Collectible_Blood_Oath_icon.png/revision/latest?cb=20210822150324 | |
Playdough Cookie | Grants multicolored tears. Each color comes with a different status or tear effect. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/3d/Collectible_Playdough_Cookie_icon.png/revision/latest?cb=20210824095927 | |
Orphan Socks | Prevents creep and floor spikes from damaging Isaac. Also gives Isaac +0.3 speed and 2 Soul Hearts. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/99/Collectible_Orphan_Socks_icon.png/revision/latest?cb=20210824095906 | |
Eye of the Occult | +1 damage, +2 range, -0.16 shot speed. Isaac's tears can be controlled mid-flight with tear controls. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/dc/Collectible_Eye_of_the_Occult_icon.png/revision/latest?cb=20210824100236 | |
Immaculate Heart | Adds one Red Heart Container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/e0/Collectible_Immaculate_Heart_icon.png/revision/latest?cb=20210824095845 | |
Monstrance | Isaac gains an aura that deals damage to enemies inside it. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/aa/Collectible_Monstrance_icon.png/revision/latest?cb=20210824095824 | |
The Intruder | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/ae/Collectible_The_Intruder_icon.png/revision/latest?cb=20210824095803 | |
Dirty Mind | Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/60/Collectible_Dirty_Mind_icon.png/revision/latest?cb=20210824095742 | |
Spirit Sword | Instead of tears, Isaac swings a sword. Charging does a spin attack and fires a projectile, and a projectile is sometimes fired with normal swings if Isaac has no empty Red Heart Containers. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/f9/Collectible_Spirit_Sword_icon.png/revision/latest?cb=20210824095720 | |
Psy Fly | Spawns a fly orbital familiar that seeks out incoming enemy shots and destroys them. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/c9/Collectible_Psy_Fly_icon.png/revision/latest?cb=20210822145744 | |
Rocket in a Jar | +5 Bombs. If Isaac is currently firing, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/3d/Collectible_Rocket_in_a_Jar_icon.png/revision/latest?cb=20210824095659 | |
The Stairway | Generates a ladder at the start of every floor that leads to a unique Angel Room shop. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/e9/Collectible_The_Stairway_icon.png/revision/latest?cb=20210824095617 | |
Sol | Reveals the location of the Boss Room. Upon defeating a boss, activates XIX - The Sun, fully recharges Isaac's active item, grants bonus damage and luck for the rest of the floor, and removes curses. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/95/Collectible_Sol_icon.png/revision/latest?cb=20210824095553 | |
Luna | Adds an extra Secret Room and Super Secret Room to each floor. Secret Rooms contain a beam of light that increases Fire Rate for the current floor and gives a Half Soul Heart. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/8e/Collectible_Luna_icon.png/revision/latest?cb=20210824095532 | |
Mercurius | +0.4 speed. Doors stay open after entering a room, even in rooms with enemies. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/96/Collectible_Mercurius_icon.png/revision/latest?cb=20210824095511 | |
Venus | Adds one red Heart container. Heals 1 additional Red Heart. Enemies near Isaac become charmed. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/21/Collectible_Venus_icon.png/revision/latest?cb=20210824095450 | |
Terra | +1 Damage. Replaces tears with rocks that deal variable damage, have increased knockback, and can destroy obstacles. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/ed/Collectible_Terra_icon.png/revision/latest?cb=20210824095430 | |
Mars | Dash by double-tapping the movement key, becoming invulnerable and damaging enemies. There's a short cooldown before Isaac can dash again. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/3e/Collectible_Mars_icon.png/revision/latest?cb=20210824095409 | |
Jupiter | +2 red Heart containers, -0.3 speed. Isaac builds speed while standing still, and releases poison gas clouds when he moves afterwards. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/60/Collectible_Jupiter_icon.png/revision/latest?cb=20210824095348 | |
Saturnus | Upon entering a room, a circle of tears orbits Isaac. Enemy tears have a chance to be caught in orbit, turning them friendly. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/0a/Collectible_Saturnus_icon.png/revision/latest?cb=20210824095327 | |
Uranus | Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/ab/Collectible_Uranus_icon.png/revision/latest?cb=20210824095306 | |
Neptunus | Isaac's mouth fills with tears over time while not firing, up to a cap. Holding the fire button will release all stored tears in rapid succession. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/20/Collectible_Neptunus_icon.png/revision/latest?cb=20210824095245 | |
Pluto | +0.7 tears. Significantly shrinks Isaac, allowing him to squeeze between objects and makes some enemy shots pass over him. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/9b/Collectible_Pluto_icon.png/revision/latest?cb=20210824095224 | |
Voodoo Head | Spawns an additional Curse Room on each floor. Curse Rooms have improved layouts. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/1f/Collectible_Voodoo_Head_icon.png/revision/latest?cb=20210824095203 | |
Eye Drops | Increases the fire rate in Isaac's left eye, causing his eyes to fire at different rates. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/62/Collectible_Eye_Drops_icon.png/revision/latest?cb=20210824095141 | |
Act of Contrition | +0.7 tears, grants an Eternal Heart. Allows Angel Rooms to appear even if a Devil Deal has been taken before. Reduces the Devil/Angel room chance penalty for taking Red heart damage. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/dc/Collectible_Act_of_Contrition_icon.png/revision/latest?cb=20210824095120 | |
Member Card | Adds a trapdoor to every Shop that leads to a second shop with a unique stock and marked-up prices. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/27/Collectible_Member_Card_icon.png/revision/latest?cb=20210824095059 | |
Battery Pack | Recharges Isaac's currently held active item and drops 2-4 batteries. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/98/Collectible_Battery_Pack_icon.png/revision/latest?cb=20210822145810 | |
Ocular Rift | Adds a chance to fire tears that create rifts where they land, which suck enemies, pickups, and shots towards them and damage enemies in the area. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/01/Collectible_Ocular_Rift_icon.png/revision/latest?cb=20210824095038 | |
Boiled Baby | Gives Isaac a familiar that fires chaotic bursts of tears in all directions. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/00/Collectible_Boiled_Baby_icon.png/revision/latest?cb=20210824095017 | |
Freezer Baby | Spawns a shooting familiar that has a chance to petrify enemies, and freezes monsters upon killing them. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/29/Collectible_Freezer_Baby_icon.png/revision/latest?cb=20210824094955 | |
Bird Cage | The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Dead Bird. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/87/Collectible_Bird_Cage_icon.png/revision/latest?cb=20210824094934 | |
Lost Soul | Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul Hearts, Eternal Hearts, or an Item. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/2e/Collectible_Lost_Soul_icon.png/revision/latest?cb=20210824094912 | |
Blood Bombs | Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place Bombs at the cost of half a heart if he doesn't have any. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a6/Collectible_Blood_Bombs_icon.png/revision/latest?cb=20210824094851 | |
Lil Dumpy | Spawns a Dumpy familiar that pushes away nearby enemies and projectiles just before Isaac is about to be hit, then falls asleep. He can be awoken by walking to him. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/61/Collectible_Lil_Dumpy_icon.png/revision/latest?cb=20210824094829 | |
Bird's Eye | Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/53/Collectible_Bird%27s_Eye_icon.png/revision/latest?cb=20210824094808 | |
Lodestone | Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/82/Collectible_Lodestone_icon.png/revision/latest?cb=20210824094747 | |
Rotten Tomato | Adds a chance to fire tears that mark enemies with the Bait status effect. Enemies marked as bait are attacked by other enemies. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a6/Collectible_Rotten_Tomato_icon.png/revision/latest?cb=20210824094726 | |
Birthright | Grants a character-specific effect that enhances their special abilities. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/70/Collectible_Birthright_icon.png/revision/latest?cb=20210824094704 | |
Red Stew | Refills all heart containers. Grants an enormous damage boost that wears off over time. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a6/Collectible_Red_Stew_icon.png/revision/latest?cb=20210824094643 | |
Booster Pack | Drops 5 random cards. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/e0/Collectible_Booster_Pack_icon.png/revision/latest?cb=20210822145837 | |
Knife Piece 1 | Combined with Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/ca/Collectible_Knife_Piece_1_icon.png/revision/latest?cb=20210824094623 | |
Knife Piece 2 | Combined with Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/4c/Collectible_Knife_Piece_2_icon.png/revision/latest?cb=20210824094602 | |
Bot Fly | Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/6c/Collectible_Bot_Fly_icon.png/revision/latest?cb=20210824092101 | |
Evil Charm | +2 luck. Provides immunity to burn, confusion, fear, and poison. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/36/Collectible_Evil_Charm_icon.png/revision/latest?cb=20210824094541 | |
Dogma | Grants flight, +2 damage, and increases speed to 1.1. Grants enough health to have 6 full hearts, if possible. Grants the Holy Mantle effect for the room it was obtained in. Automatically given to Isaac after defeating Dogma. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/1b/Collectible_Dogma_icon.png/revision/latest?cb=20210824094519 | |
Purgatory | While in a room with enemies, spawns red cracks in the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/38/Collectible_Purgatory_icon.png/revision/latest?cb=20210824094458 | |
Knockout Drops | Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/c3/Collectible_Knockout_Drops_icon.png/revision/latest?cb=20210822150207 | |
Akeldama | While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/91/Collectible_Akeldama_icon.png/revision/latest?cb=20210824094437 | |
Revelation | Grants flight and two Soul Hearts. In addition to tears, Isaac can charge up and fire a powerful holy laser. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/94/Collectible_Revelation_icon.png/revision/latest?cb=20210821031539 | |
Consolation Prize | Increases Isaac's lowest stat and drops either 3 Coins, 1 Bomb, or 1 Key depending on what Isaac has the least of. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/f0/Collectible_Consolation_Prize_icon.png/revision/latest?cb=20210822105122 | |
Tinytoma | Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/ff/Collectible_Tinytoma_icon.png/revision/latest?cb=20210824094414 | |
Brimstone Bombs | +5 Bombs. Bombs fire four Brimstone lasers in the cardinal directions upon exploding. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/23/Collectible_Brimstone_Bombs_icon.png/revision/latest?cb=20210824094354 | |
4.5 Volt | Active items don't charge when clearing rooms. Instead, they're charged by dealing damage to enemies. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/25/Collectible_4.5_Volt_icon.png/revision/latest?cb=20210824094332 | |
Fruity Plum | Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/66/Collectible_Fruity_Plum_icon.png/revision/latest?cb=20210824094311 | |
Star of Bethlehem | Spawns a star familiar that slowly travels towards the Boss Room, giving an aura that increases damage and tears and grants homing tears. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/07/Collectible_Star_of_Bethlehem_icon.png/revision/latest?cb=20210824094250 | |
Cube Baby | Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/b/b3/Collectible_Cube_Baby_icon.png/revision/latest?cb=20210824093322 | |
False PHD | Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/57/Collectible_False_PHD_icon.png/revision/latest?cb=20210822145903 | |
Vasculitis | Enemies explode into tears upon death, which inherit the effects of Isaac's tears. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/31/Collectible_Vasculitis_icon.png/revision/latest?cb=20210824094208 | |
Giant Cell | Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/24/Collectible_Giant_Cell_icon.png/revision/latest?cb=20210824093632 | |
Tropicamide | +2.5 Range, Increases tear size. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/4c/Collectible_Tropicamide_icon.png/revision/latest?cb=20210824094147 | |
Card Reading | Spawns two portals at the beginning of each floor that each lead to either the Boss Room, Treasure Room, Secret Room, or the Shop. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/b/b4/Collectible_Card_Reading_icon.png/revision/latest?cb=20210824094106 | |
Quints | The first five enemies killed in a room will spawn stationary shooting familiars where they died. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a8/Collectible_Quints_icon.png/revision/latest?cb=20210824092559 | |
Tooth and Nail | Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/d8/Collectible_Tooth_and_Nail_icon.png/revision/latest?cb=20210824093510 | |
Binge Eater | +1 Red Heart Container and fully heals Isaac. Item pedestals also offer a random food item. Picking up a food item temporarily grants +3.6 damage and permanently boosts 2 stats. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/f2/Collectible_Binge_Eater_icon.png/revision/latest?cb=20210824094045 | |
Guppy's Eye | Shows the contents of Chests, Fire Places, Grab Bags, and Shopkeepers before they're opened/destroyed. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/17/Collectible_Guppy%27s_Eye_icon.png/revision/latest?cb=20210824094024 | |
Strawman | Spawns a controllable Keeper to fight enemies alongside Isaac, functioning similarly to Jacob and Esau. If Keeper dies, he spawns 5 blue spiders and Strawman is removed from Isaac's inventory. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/49/Collectible_Strawman_icon.png/revision/latest?cb=20210824094003 | |
Dad's Note | Sends Isaac on an Ascent toward Home. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/51/Collectible_Dad%27s_Note_icon.png/revision/latest?cb=20210824093942 | |
Sausage | Adds a Red Heart Container, fully heals Isaac, and gives +0.2 Speed, +0.5 Damage, +0.5 Tears, +2.5 Range, +0.2 Shot Speed, and +1.0 Luck. Increases the chance of encountering a Devil Room, Angel Room, and/or Planetarium each by 6.9%. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/1e/Collectible_Sausage_icon.png/revision/latest?cb=20210824093922 | |
Options? | If a room gives a reward when cleared, there will be two different rewards to chose from. Taking one causes the other to disappear. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/06/Collectible_Options%3F_icon.png/revision/latest?cb=20210824093901 | |
Candy Heart | Gives Isaac a permanent stat boost whenever he heals with Red Heart pickups. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/db/Collectible_Candy_Heart_icon.png/revision/latest?cb=20210824093839 | |
A Pound of Flesh | Devil deals now cost Coins, Shop items now cost health, and consumables in shops are free but surrounded by spikes. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/6c/Collectible_A_Pound_of_Flesh_icon.png/revision/latest?cb=20210824093818 | |
Redemption | If Isaac enters a Devil Room but leaves without taking/opening anything in it, he gets +1 Damage and a Soul Heart at the start of the next floor. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/64/Collectible_Redemption_icon.png/revision/latest?cb=20210824093757 | |
Spirit Shackles | On death, Isaac's ghost is chained to his dead body and he can continue to fight with 1/2 of a heart, returning to life after 10 seconds. After it activates, it must be recharged by picking up a Soul Heart. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/12/Collectible_Spirit_Shackles_icon.png/revision/latest?cb=20210824093736 | |
Cracked Orb | Unlocks doors and reveals a random room on the map when Isaac takes damage. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/39/Collectible_Cracked_Orb_icon.png/revision/latest?cb=20210824093714 | |
Empty Heart | If Isaac has one red heart or fewer at the beginning of a floor, he gains an empty red heart container. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/3d/Collectible_Empty_Heart_icon.png/revision/latest?cb=20210824093654 | |
Astral Projection | Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/84/Collectible_Astral_Projection_icon.png/revision/latest?cb=20210824093448 | |
C Section | Replaces tears with fetuses that chase down enemies and deal contact damage. Each shot requires a brief charge up. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/8b/Collectible_C_Section_icon.png/revision/latest?cb=20210824093426 | |
Lil Abaddon | Spawns a familiar that charges a miniature Maw Of The Void attack while Isaac shoots. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/4c/Collectible_Lil_Abaddon_icon.png/revision/latest?cb=20210824093404 | |
Montezuma's Revenge | While firing, Isaac charges up a short-ranged Brimstone-like diarrhea beam that shoots behind him. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/58/Collectible_Montezuma%27s_Revenge_icon.png/revision/latest?cb=20210824093344 | |
Lil Portal | A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/0a/Collectible_Lil_Portal_icon.png/revision/latest?cb=20210824093301 | |
Worm Friend | Gives Isaac a Nerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/7e/Collectible_Worm_Friend_icon.png/revision/latest?cb=20210824093220 | |
Bone Spurs | Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/d5/Collectible_Bone_Spurs_icon.png/revision/latest?cb=20210824093200 | |
Hungry Soul | Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/e0/Collectible_Hungry_Soul_icon.png/revision/latest?cb=20210824093138 | |
Soul Locket | Gives Isaac a permanent stat boost whenever he picks up a Soul Heart. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/fc/Collectible_Soul_Locket_icon.png/revision/latest?cb=20210824093116 | |
Inner Child | Upon death, Isaac respawns in the current room with half of a Red Heart, a massive size down, and +0.2 Speed. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/00/Collectible_Inner_Child_icon.png/revision/latest?cb=20210824093056 | |
Glitched Crown | Item pedestals cycle between 5 random items before being picked up. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/8c/Collectible_Glitched_Crown_icon.png/revision/latest?cb=20210824093035 | |
Belly Jelly | Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/ac/Collectible_Belly_Jelly_icon.png/revision/latest?cb=20210824093014 | |
Sacred Orb | Prevents items of quality 0-1 from appearing, and items of quality 2 from appearing 33% of the time. Quest items are unaffected. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/0f/Collectible_Sacred_Orb_icon.png/revision/latest?cb=20210824092952 | |
Sanguine Bond | Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/fa/Collectible_Sanguine_Bond_icon.png/revision/latest?cb=20210824092930 | |
The Swarm | Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/9d/Collectible_The_Swarm_icon.png/revision/latest?cb=20210824092909 | |
Heartbreak | Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts. | https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/8e/Collectible_Heartbreak_icon.png/revision/latest?cb=20210824092848 |
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