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Circle of Protection
Surrounds Isaac with a large white halo that occasionally deals Isaac's tear damage to enemies inside it, and can convert enemy shots into friendly homing tears.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/93/Collectible_Circle_of_Protection_icon.png/revision/latest?cb=20210821162606
Sack Head
Spawns a Grab Bag on pickup. Coins, Bombs, Keys, cards, runes and batteries have a chance to become Grab Bags.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/7a/Collectible_Sack_Head_icon.png/revision/latest?cb=20210821134849
Night Light
A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/71/Collectible_Night_Light_icon.png/revision/latest?cb=20210821145758
Obsessed Fan
Spawns a familiar that follows Isaac's movements on a delay and deals 30 contact damage per second to enemies.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/2a/Collectible_Obsessed_Fan_icon.png/revision/latest?cb=20210821182742
PJs
Grants 4 Soul Hearts and fully restores Isaac's health.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/b/b6/Collectible_PJs_icon.png/revision/latest?cb=20210821150319
Head of the Keeper
Isaac's tears become coins. Hitting an enemy has a 5% chance to drop a Penny.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/68/Collectible_Head_of_the_Keeper_icon.png/revision/latest?cb=20210821182525
Papa Fly
Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/93/Collectible_Papa_Fly_icon.png/revision/latest?cb=20210821183028
Multidimensional Baby
Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/2b/Collectible_Multidimensional_Baby_icon.png/revision/latest?cb=20210821150633
Glitter Bombs
+5 Bombs. Bombs have a chance to drop random pickups or charm enemies when they explode.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/41/Collectible_Glitter_Bombs_icon.png/revision/latest?cb=20210821150348
My Shadow
Inflicts fear on all enemies in the room upon taking damage and spawns black friendly Chargers that attack enemies. Spawns a shadow familiar that closely follows behind Isaac. It spawns a black friendly Charger whenever an enemy touches it.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/4c/Collectible_My_Shadow_icon.png/revision/latest?cb=20210821163754
Lil Loki
Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/da/Collectible_Lil_Loki_icon.png/revision/latest?cb=20210821182500
Milk!
Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room. After the milk spills, Isaac's fire rate is increased by 1 for the current room.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/cc/Collectible_Milk%21_icon.png/revision/latest?cb=20210821182810
Binky
Grants one Soul Heart, +0.75 tears and decreases Isaac's size.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/75/Collectible_Binky_icon.png/revision/latest?cb=20210821150424
Kidney Stone
Isaac is occasionally forced to stop firing and charge an attack that launches a massive piercing, spectral kidney stone and a barrage of tears. -0.2 speed, decreases range.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/eb/Collectible_Kidney_Stone_icon.png/revision/latest?cb=20210821163625
Dark Prince's Crown
When at exactly one Red Heart, +0.75 tears, +1.5 range, and +0.2 shot speed. When at exactly one Red Heart, +2 fire rate, +1.5 range, and +0.2 shot speed.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/01/Collectible_Dark_Prince%27s_Crown_icon.png/revision/latest?cb=20210822015132
Apple!
+0.3 tears. Adds a chance to fire a razor blade that deals 4× Isaac's damage.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/65/Collectible_Apple%21_icon.png/revision/latest?cb=20210822014307
Lead Pencil
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/2f/Collectible_Lead_Pencil_icon.png/revision/latest?cb=20210822020422
Dog Tooth
+0.3 damage, +0.1 speed. Plays a howl or bark sound when entering a room with undiscovered Secret Rooms or Crawl Spaces.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/76/Collectible_Dog_Tooth_icon.png/revision/latest?cb=20210822015439
Dead Tooth
While firing, Isaac gains a green aura that poisons nearby enemies.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/62/Collectible_Dead_Tooth_icon.png/revision/latest?cb=20210822015236
Linger Bean
Constantly shooting causes Isaac to release gas clouds that can be pushed by his tears and damage nearby enemies.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/9e/Collectible_Linger_Bean_icon.png/revision/latest?cb=20210822020502
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room. Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/13/Collectible_Shard_of_Glass_icon.png/revision/latest?cb=20210822021323
Metal Plate
Grants one Soul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a5/Collectible_Metal_Plate_icon.png/revision/latest?cb=20210822020645
Eye of Greed
Every 20 tears, Isaac loses 1 Penny and shoots an additional gold tear that petrifies enemies and turns them into gold. Any enemy killed while in this state will drop coins.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/26/Collectible_Eye_of_Greed_icon.png/revision/latest?cb=20210822015844
Tarot Cloth
Drops a random card or rune. Doubles the effects of most cards and runes. Doubles the effects of tarot cards.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/7c/Collectible_Tarot_Cloth_icon.png/revision/latest?cb=20210822021609
Varicose Veins
Taking damage releases a ring of 10 high damage tears.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a0/Collectible_Varicose_Veins_icon.png/revision/latest?cb=20210822021724
Compound Fracture
Increases Range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/e1/Collectible_Compound_Fracture_icon.png/revision/latest?cb=20210822014751
Polydactyly
Allows Isaac to carry two cards, pills, or any combination of both. Spawns one random card, rune, or pill.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/26/Collectible_Polydactyly_icon.png/revision/latest?cb=20210822021111
Dad's Lost Coin
+1.5 range, +1 tear falling speed. Drops a Lucky Penny. +2.5 range. Drops a Lucky Penny.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/d0/Collectible_Dad%27s_Lost_Coin_icon.png/revision/latest?cb=20210822015102
Midnight Snack
Grants one full Red Heart container. Heals 1 additional Red Heart.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/9a/Collectible_Midnight_Snack_icon.png/revision/latest?cb=20210822020801
Cone Head
Grants a Soul Heart. Gives Isaac a chance to ignore any damage taken.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/af/Collectible_Cone_Head_icon.png/revision/latest?cb=20210822014817
Belly Button
Drops a random trinket. Grants a second trinket slot.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a4/Collectible_Belly_Button_icon.png/revision/latest?cb=20210822014419
Sinus Infection
Adds a chance to fire a booger that sticks to enemies and deals damage over time.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/03/Collectible_Sinus_Infection_icon.png/revision/latest?cb=20210822021430
Glaucoma
Adds a chance to shoot tears that confuse enemies for an extremely long time.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/27/Collectible_Glaucoma_icon.png/revision/latest?cb=20210822020031
Parasitoid
Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/af/Collectible_Parasitoid_icon.png/revision/latest?cb=20210822020900
Eye of Belial
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/1f/Collectible_Eye_of_Belial_icon.png/revision/latest?cb=20210822015805
Sulfuric Acid
+0.3 damage. Adds a chance to fire acidic tears which can destroy obstacles and open doors.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/b/be/Collectible_Sulfuric_Acid_icon.png/revision/latest?cb=20210822021543
Glyph of Balance
Grants 2 Soul Hearts and modifies drops from Champion monsters based on certain conditions. Also modifies room clear drops.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/50/Collectible_Glyph_of_Balance_icon.png/revision/latest?cb=20210822020100
Analog Stick
+0.35 tears up. Allows Isaac to fire tears diagonally.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/c2/Collectible_Analog_Stick_icon.png/revision/latest?cb=20210822014235
Contagion
The first enemy killed in a room releases a gas cloud that poisons nearby enemies. Affected enemies will also release gas upon death, spreading the effect.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/d9/Collectible_Contagion_icon.png/revision/latest?cb=20210822014847
Finger!
Spawns a finger familiar that faces in the same direction as Isaac, rapidly damaging enemies it points at for 10% of Isaac's damage.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/2f/Collectible_Finger%21_icon.png/revision/latest?cb=20210822015923
Shade
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/59/Collectible_Shade_icon.png/revision/latest?cb=20210822021255
Depression
Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/85/Collectible_Depression_icon.png/revision/latest?cb=20210822015358
Hushy
Spawns a Error: Error: The given entity ("Hush") does not exist. familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/8f/Collectible_Hushy_icon.png/revision/latest?cb=20210822020208
Lil Monstro
Spawns a familiar that fires clusters of tears. Must be charged before shooting.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/21/Collectible_Lil_Monstro_icon.png/revision/latest?cb=20210821211013
King Baby
Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, other familiars stop moving.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/f9/Collectible_King_Baby_icon.png/revision/latest?cb=20210822020305
Big Chubby
Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/b/bc/Collectible_Big_Chubby_icon.png/revision/latest?cb=20210822014451
Tonsil
Grants a familiar that follows Isaac and blocks enemy shots.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/8f/Trinket_Tonsil_icon.png/revision/latest?cb=20210825081441
Acid Baby
Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/95/Collectible_Acid_Baby_icon.png/revision/latest?cb=20210822014123
YO LISTEN!
+1 luck. Spawns a fairy familiar that points out Secret Rooms, Crawl Space entrances, and tinted rocks.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/63/Collectible_YO_LISTEN%21_icon.png/revision/latest?cb=20210822021643
Adrenaline
Increases damage based on how many empty Red Heart containers Isaac has.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/80/Collectible_Adrenaline_icon.png/revision/latest?cb=20210822014206
Jacob's Ladder
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/31/Collectible_Jacob%27s_Ladder_icon.png/revision/latest?cb=20210822020235
Ghost Pepper
Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them. Gives a chance to shoot blue fires alongside tears that become smaller as they travel.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a3/Collectible_Ghost_Pepper_icon.png/revision/latest?cb=20210822020002
Euthanasia
Adds a luck-based chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/ca/Collectible_Euthanasia_icon.png/revision/latest?cb=20210822015723
Camo Undies
Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused. Isaac gains +0.5 Speed while camouflaged, and gains Tears and Damage upon breaking it.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/dd/Collectible_Camo_Undies_icon.png/revision/latest?cb=20210822014623
Duality
Whenever a Devil Room or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/dc/Collectible_Duality_icon.png/revision/latest?cb=20210822015508
Eucharist
An Angel Room will always spawn after every boss fight, excluding the first floor and floors after Chapter 4.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/f8/Collectible_Eucharist_icon.png/revision/latest?cb=20210822015650
Sack of Sacks
Spawns a familiar that drops a Grab Bag every 5-6 rooms cleared.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/1e/Collectible_Sack_of_Sacks_icon.png/revision/latest?cb=20210822021220
Greed's Gullet
Grants a Red Heart container for every 25 Coins Isaac has.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/23/Collectible_Greed%27s_Gullet_icon.png/revision/latest?cb=20210822020132
Large Zit
Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/43/Collectible_Large_Zit_icon.png/revision/latest?cb=20210822020341
Little Horn
Adds a chance to fire a piercing tear that instantly kills any enemy that it touches. Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/97/Collectible_Little_Horn_icon.png/revision/latest?cb=20210822020536
Poke Go
Upon entering a room with enemies in it, has a chance to spawn a random friendly enemy that persists across rooms.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/24/Collectible_Poke_Go_icon.png/revision/latest?cb=20210822021043
Backstabber
Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/5d/Collectible_Backstabber_icon.png/revision/latest?cb=20210822014338
Mom's Razor
Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/2d/Collectible_Mom%27s_Razor_icon.png/revision/latest?cb=20210822020830
Bloodshot Eye
Spawns an orbital familiar that deals contact damage and fires a tear every 2 seconds. Spawns an orbital familiar that deals contact damage, blocks shots, and fires tears at enemies in its line of sight.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/22/Collectible_Bloodshot_Eye_icon.png/revision/latest?cb=20210822014522
Angry Fly
Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/07/Collectible_Angry_Fly_icon.png/revision/latest?cb=20210822050012
Bozo
+0.1 flat damage, grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a Rainbow Poop.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/c6/Collectible_Bozo_icon.png/revision/latest?cb=20210822050109
Broken Modem
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals. The reward from clearing a room will sometimes be duplicated.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/6/6c/Collectible_Broken_Modem_icon.png/revision/latest?cb=20210822050137
Fast Bombs
+7 Bombs. Removes the delay between bomb placements, allowing them to be placed rapidly. Bombs will no longer knock each other away.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/ee/Collectible_Fast_Bombs_icon.png/revision/latest?cb=20210822045824
Buddy in a Box
Spawns a familiar with a random tear effect. The familiar is randomized at the start of each floor.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/af/Collectible_Buddy_in_a_Box_icon.png/revision/latest?cb=20210822045754
Lil Delirium
Grants a familiar that transforms into another random familiar every 10 seconds.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/7d/Collectible_Lil_Delirium_icon.png/revision/latest?cb=20210822045849
Jumper Cables
Grants an active item charge every 15 enemies killed.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/0c/Collectible_Jumper_Cables_icon.png/revision/latest?cb=20210822050657
Technology Zero
Connects Isaac's tears with electricity that can damage enemies.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/3b/Collectible_Technology_Zero_icon.png/revision/latest?cb=20210822050812
Leprosy
Taking damage grants a body part orbital that blocks shots and deals contact damage, up to a maximum of three. The body parts are destroyed after blocking enough damage.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/0/01/Collectible_Leprosy_icon.png/revision/latest?cb=20210822050724
7 Seals
Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/90/Collectible_7_Seals_icon.png/revision/latest?cb=20210822062850
Angelic Prism
Spawns an orbital familiar with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/c/c7/Collectible_Angelic_Prism_icon.png/revision/latest?cb=20210822062758
Pop!
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/76/Collectible_Pop%21_icon.png/revision/latest?cb=20210822062733
Death's List
Grants a pickup or stat upgrade if all enemies in a room are killed in the order they are marked.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/9d/Collectible_Death%27s_List_icon.png/revision/latest?cb=20210822064754
Haemolacria
Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/48/Collectible_Haemolacria_icon.png/revision/latest?cb=20210822064726
Lachryphagy
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/30/Collectible_Lachryphagy_icon.png/revision/latest?cb=20210822064658
Trisagion
Tears are replaced with piercing white blasts of light that deal less damage but can damage the same enemy multiple times.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/2/25/Collectible_Trisagion_icon.png/revision/latest?cb=20210822064628
Schoolbag
Allows Isaac to hold two active items.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/d7/Collectible_Schoolbag_icon.png/revision/latest?cb=20210822064600
Blanket
Grants one Soul Heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/e2/Collectible_Blanket_icon.png/revision/latest?cb=20210822090842
Lil Spewer
Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/a/a3/Collectible_Lil_Spewer_icon.png/revision/latest?cb=20210822090936
Marbles
Spawns 3 random trinkets. Taking damage has a 5% chance to swallow Isaac's currently held trinket, gaining its effect permanently.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/3/38/Collectible_Marbles_icon.png/revision/latest?cb=20210822091000
Mystery Egg
Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room. The power of the monster improves for each consecutive room cleared without taking damage.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/5f/Collectible_Mystery_Egg_icon.png/revision/latest?cb=20210822091029
Flat Stone
Tears bounce off the floor, creating splashes. Splashes deal 25% of Isaac's tear damage to all enemies in a small area.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/46/Collectible_Flat_Stone_icon.png/revision/latest?cb=20210822091053
Marrow
Grants one Bone Heart and spawns three Red Hearts.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/59/Collectible_Marrow_icon.png/revision/latest?cb=20210822091122
Slipped Rib
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/77/Collectible_Slipped_Rib_icon.png/revision/latest?cb=20210822091149
Hallowed Ground
Spawns a white poop familiar, which turns into a White Poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots. The aura also increases damage by 20% and gives homing.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/5/51/Collectible_Hallowed_Ground_icon.png/revision/latest?cb=20210822091216
Pointy Rib
Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/b/b4/Collectible_Pointy_Rib_icon.png/revision/latest?cb=20210822091243
Dad's Ring
Creates a ring of light around Isaac that petrifies enemies in contact.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/e/e5/Collectible_Dad%27s_Ring_icon.png/revision/latest?cb=20210822091337
Divorce Papers
Grants one Bone Heart, +0.7 tears, spawns a Mysterious Paper.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/8/8e/Collectible_Divorce_Papers_icon.png/revision/latest?cb=20210822091404
Jaw Bone
Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/b/bc/Collectible_Jaw_Bone_icon.png/revision/latest?cb=20210822091433
Brittle Bones
Replaces all Red Heart Containers with 6 empty Bone Hearts. Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a tears up. Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a fire rate up.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/4/49/Collectible_Brittle_Bones_icon.png/revision/latest?cb=20210822091500
Broken Shovel 2
One of two parts necessary to create Mom's Shovel. No effect if somehow obtained on its own.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/d/d6/Collectible_Broken_Shovel_2_icon.png/revision/latest?cb=20210822091553
Mucormycosis
Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/f0/Collectible_Mucormycosis_icon.png/revision/latest?cb=20210824093551
2Spooky
Enemies near Isaac are afflicted with fear.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/9/92/Collectible_2Spooky_icon.png/revision/latest?cb=20210824100215
Eye Sore
Causes Isaac to occasionally fire extra tears in random directions while shooting.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/10/Collectible_Eye_Sore_icon.png/revision/latest?cb=20210824100154
120 Volt
Repeatedly zaps enemies that are close to Isaac.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/7/7c/Collectible_120_Volt_icon.png/revision/latest?cb=20210824100133
It Hurts
Releases a ring of tears and increases fire rate for the current room when Isaac takes damage.
https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/f/f5/Collectible_It_Hurts_icon.png/revision/latest?cb=20210822150350