Datasets:
PRMegathon26
/
PISCES

Dataset card Data Studio Files
xet
 Community
1
pdb_code
stringlengths
4
4
release_date
stringdate
1991-10-15 00:00:00
2026-01-28 00:00:00
classification
stringclasses
1 value
chains
stringlengths
61
5.01k
formula_weight
float64
387
271k
symmetry
stringclasses
66 values
crystal_structure(a|b|c|alpha|beta|gamma)
stringlengths
5
45
exptl_method
stringclasses
6 values
synthesis_comment
stringclasses
73 values
authors
stringlengths
7
521
⌀
publication
stringlengths
15
254
publication_ref(doi|pubmed|csd|issn|astm)
stringlengths
4
62
publication_country
stringclasses
9 values
subtitle
stringlengths
6
213
tags
stringlengths
9
287
sequence_related_designs_above_50_bits
stringlengths
8
1.39k
⌀
sequence_related_natural_proteins_above_50_bits
stringlengths
8
115k
⌀
structure_related_designs_above_95_lddt
stringlengths
7
1.13k
⌀
structure_related_natural_above_95_lddt
stringclasses
247 values
highest_sequence_related_design
stringlengths
7
10
⌀
highest_sequence_related_natural_protein
stringlengths
8
10
⌀
highest_structure_related_design
stringlengths
7
18
⌀
highest_structure_related_natural_protein
stringlengths
7
18
⌀
cath_full
stringlengths
9
3.45k
⌀
data_curation_comments
stringclasses
3 values
6c9k
2018-03-21
other
id:A,B,C,D,I,J,K,L,Q,R,S,T;type:D;source:synthetic;length:322;seq_nat:MRITTKVGDKGSTRLFGGEEVWKDSPIIEANGTLDELTSFIGEAKHYVDEEMKGILEEIQNDIYKIMGEIGSKGKIEGISEERIAWLLKLILRYMEMVNLKSFVLPGGTLESAKLDVCRTIARRALRKVLTVTREFGIGAEAAAYLLALSDLLFLLARVIEIELGKKLLEAARAGQDDEVRILMANGADVNAHDDQGSTPLHLAAWIGHPEIVEVLLKHGADVNARDTDGWTPLHLAADNGHLEIVEVLL...
35,018.965
null
|||||
ELECTRON MICROSCOPY
null
Y. Liu;S. Gonen;T. Gonen;T.O. Yeates
"Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system", Proc. Natl. Acad. Sci. U.S.A., 115, 3362-3367
10.1073/pnas.1718825115|29507202|0040|1091-6490|PNASA6
US
Single-particle reconstruction of darp14 - a designed protein scaffold displaying ~17kda darpin proteins
scaffold;darpin;single-particle cryo-em;de novo protein;designed complex
8ve7(582);8v9o(315);8vdz(271);5op3(269);5oou(266);5oos(265);7dng(265);7dnf(265);7b4w(264);2bkg(264);8ql6(261);8ql5(261);8ql9(261);9u6a(261);8ql2(261);8ql3(261);9f8g(261);8qlb(261);8qla(261);8ql7(261);8ql8(261);8qea(261);8ql4(261);4dui(261);9f22(260);6fpa(260);6fpb(260);9fe2(259);9fe3(259);7z7e(258);6fp9(258);4atz(257);...
3zu7(324);6c9i(321);1wy1(292);5cy5(281);5oyj(275);4f6r(269);4hna(269);5mad(267);3noc(265);3nog(265);5o2s(265);5mlb(265);2p2c(263);5o2t(263);5mla(263);5nm5(261);5eib(261);1svx(261);4lnu(261);5nqt(261);5nqu(261);4drx(261);2bkk(260);5enr(259);5nc5(259);4dx6(259);4u96(259);5ens(259);4dx7(259);4u8v(259);5en5(259);5jmn(259);...
null
null
8ve7(582)
3zu7(324)
8vdz(0.9433000088)
6c9i(0.9478999972)
1.20.120.160;1.20.1440.150;1.25.10.10;1.20.120.290;1.20.1440.70;1.10.8.930;1.20.900.10;1.20.120.1370;1.25.40.750;1.25.40.70;1.20.58.1800;1.20.120.960;1.25.40.580;1.20.1440.20;1.20.1440.210;1.20.120.50;1.25.40.850;1.20.1440.60;1.25.40.290;1.25.60.10;1.25.40.10;1.20.1260.10;1.25.40.320;1.20.1050.50;1.25.40.490;1.10.490.1...
null
6cfa
2019-03-06
other
id:A;type:U;source:unknown;length:19;seq_nat:PMARNKKLLKKLRLKIAFK;seq_unnat:PMARNKKLLKKLRLKIAFK
2,305.013
null
|||||
SOLUTION NMR
null
E.S.F. Alves;L.M. Liao
To be published
||||
null
Peptide paamp1r3
de novo protein;design;helix
null
null
null
null
6cfa(0)
null
6cfa(0)
null
4.10.180.60;6.10.250.400;1.20.5.640;6.10.250.1960
null
6czg
2018-09-19
other
id:A,B;type:D;source:synthetic construct;length:116;seq_nat:GSSMCRAASLLPGTWQVTMTNEDGQTSQGQMHFQPRSPYTLDVKAQGTISDGRPISGKGKVTCKTPDTMDVDITYPSLGNMKVQGQLTLDSPTQFKFDGTTSDGSKLTGTLQRQE;seq_unnat:GSSMCRAASLLPGTWQVTMTNEDGQTSQGQMHFQPRSPYTLDVKAQGTISDGRPISGKGKVTCKTPDTMDVDITYPSLGNMKVQGQLTLDSPTQFKFDGTTSDGSKLTGTLQRQE
12,387.794
C 1 2 1
84.920|35.314|59.554|90.000|90.870|90.000
X-RAY DIFFRACTION
null
J. Dou;A.A. Vorobieva;W. Sheffler;L.A. Doyle;H. Park;M.J. Bick;B. Mao;G.W. Foight;M.Y. Lee;L.A. Gagnon;L. Carter;B. Sankaran;S. Ovchinnikov;E. Marcos;P.S. Huang;J.C. Vaughan;B.L. Stoddard;D. Baker
"De novo design of a fluorescence-activating beta-barrel", Nature, 561, 485-491
10.1038/s41586-018-0509-0|30209393|0006|1476-4687|NATUAS
UK
Structure of a redesigned beta barrel, b11l5f_lgl
ligand binding;de novo protein;rossetta;beta barrel;de novo;computational
6czh(193);6czi(188);6ohh(186);6czj(123);6d0t(71);8ah9(50)
null
null
null
6czh(193)
null
6czi(0.8799999952)
1jmx(0.7014999986)
2.40.128.350;2.40.128.600;2.40.128.380;2.40.128.360;2.40.128.220;2.40.128.30;2.40.128.340;2.30.31.50;2.40.128.270;2.40.128.80;2.40.160.90;2.40.128.10;2.40.128.240;2.40.128.640;2.40.128.420;2.40.128.20;2.40.370.10;2.40.128.500;2.40.128.50;2.40.128.180;2.40.128.300;2.40.160.20;2.40.128.280;2.40.128.200;2.70.130.10;2.40.1...
null
6czh
2018-09-19
other
id:A,B;type:D;source:synthetic construct;length:113;seq_nat:MSRAAQLLPGTWQVTMTNEDGQTSQGQMHFQPRSPYTLDIVAQGTISDGRPITGYGKVTVKTDDTLHVNITYPSLGNIKVQGQITMDSPTQATWNSTTSDGKKLTGTLQRQE;seq_unnat:MSRAAQLLPGTWQVTMTNEDGQTSQGQMHFQPRSPYTLDIVAQGTISDGRPITGYGKVTVKTDDTLHVNITYPSLGNIKVQGQITMDSPTQATWNSTTSDGKKLTGTLQRQE
12,237.574
P 21 21 21
48.061|59.382|72.836|90.000|90.000|90.000
X-RAY DIFFRACTION
null
J. Dou;A.A. Vorobieva;W. Sheffler;L.A. Doyle;H. Park;M.J. Bick;B. Mao;G.W. Foight;M.Y. Lee;L.A. Gagnon;L. Carter;B. Sankaran;S. Ovchinnikov;E. Marcos;P.S. Huang;J.C. Vaughan;B.L. Stoddard;D. Baker
"De novo design of a fluorescence-activating beta-barrel", Nature, 561, 485-491
10.1038/s41586-018-0509-0|30209393|0006|1476-4687|NATUAS
UK
Structure of a redesigned beta barrel, mfap0, bound to dfhbi
de novo protein;ligand binder;rossetta;beta barrel;de novo;computational
6czi(222);6czg(196);6ohh(187);6czj(112);6d0t(68)
null
null
null
6czi(222)
null
6czi(0.9409000278)
1jmx(0.7566999793)
2.40.128.350;2.40.128.600;2.40.128.380;2.40.128.360;2.40.128.30;2.40.128.340;2.40.128.270;2.40.128.80;2.40.160.90;2.40.128.10;2.40.128.240;2.40.128.640;2.40.128.420;2.40.370.10;2.40.128.50;2.40.128.180;2.40.128.300;2.40.160.20;2.40.128.280;2.40.128.200;2.70.130.10;3.30.1120.40;2.40.128.160
null
6czi
2018-09-19
other
id:A,B;type:D;source:synthetic construct;length:113;seq_nat:MSRAAQLLPGTWQVTMTNEDGQTSQGQWHFQPRSPYTLDIVAQGTISDGRPITGYGKATVKTDDTLHANLTYPSLGNIKAQGQITYDSPTQFTWNSTTSDGKKLTGTLQRQE;seq_unnat:MSRAAQLLPGTWQVTMTNEDGQTSQGQWHFQPRSPYTLDIVAQGTISDGRPITGYGKATVKTDDTLHANLTYPSLGNIKAQGQITYDSPTQFTWNSTTSDGKKLTGTLQRQE
12,316.503
P 1 21 1
40.142|47.930|52.843|90.000|91.490|90.000
X-RAY DIFFRACTION
null
J. Dou;A.A. Vorobieva;W. Sheffler;L.A. Doyle;H. Park;M.J. Bick;B. Mao;G.W. Foight;M.Y. Lee;L.A. Gagnon;L. Carter;B. Sankaran;S. Ovchinnikov;E. Marcos;P.S. Huang;J.C. Vaughan;B.L. Stoddard;D. Baker
"De novo design of a fluorescence-activating beta-barrel", Nature, 561, 485-491
10.1038/s41586-018-0509-0|30209393|0006|1476-4687|NATUAS
UK
Structure of a redesigned beta barrel, mfap1, bound to dfhbi
de novo protein;rossetta;beta barrel;de novo;computational
6czh(220);6ohh(194);6czg(190);6czj(110);6d0t(64)
null
null
null
6czh(220)
null
6ohh(0.9283000231)
1jmx(0.7238000035)
2.40.128.350;2.40.128.600;2.40.128.380;2.40.128.360;2.40.128.220;2.40.128.30;2.40.128.340;2.40.128.270;2.40.128.80;2.40.160.90;2.40.128.10;2.40.128.240;2.40.128.640;2.40.128.420;3.30.450.130;2.40.370.10;2.40.128.50;2.40.128.180;2.40.128.300;2.40.160.20;2.40.128.280;2.40.128.200;2.40.128.160
null
6czj
2018-09-19
other
id:A,B;type:D;source:synthetic construct;length:110;seq_nat:SALAQQLPGTWKMDVTSEDGVRTTGQMHIQPKTPTTMDVTLTGTHADGKPFTGQGKITVKTPTTVDITVTYEDGSTATGQLTVDSPTQFKFDMTASDGTRFTGTVQRQS;seq_unnat:SALAQQLPGTWKMDVTSEDGVRTTGQMHIQPKTPTTMDVTLTGTHADGKPFTGQGKITVKTPTTVDITVTYEDGSTATGQLTVDSPTQFKFDMTASDGTRFTGTVQRQS
11,651.869
P 1 21 1
42.915|36.678|61.912|90.000|91.080|90.000
X-RAY DIFFRACTION
null
J. Dou;A.A. Vorobieva;W. Sheffler;L.A. Doyle;H. Park;M.J. Bick;B. Mao;G.W. Foight;M.Y. Lee;L.A. Gagnon;L. Carter;B. Sankaran;S. Ovchinnikov;E. Marcos;P.S. Huang;J.C. Vaughan;B.L. Stoddard;D. Baker
"De novo design of a fluorescence-activating beta-barrel", Nature, 561, 485-491
10.1038/s41586-018-0509-0|30209393|0006|1476-4687|NATUAS
UK
Structure of a redesigned beta barrel, b10
de novo protein;rossetta;beta barrel;de novo;computational
6czg(132);6czh(118);6czi(117);6ohh(114);6d0t(77);8ah9(64)
null
null
null
6czg(132)
null
6czg(0.8626000285)
1jmx(0.7325000167)
2.40.128.350;2.40.128.600;2.40.128.380;2.40.128.360;2.40.128.220;2.40.128.30;2.40.128.340;2.30.31.50;2.40.128.270;2.40.128.80;2.40.160.90;2.40.128.10;2.40.128.240;2.40.128.640;2.30.30.660;2.40.128.420;2.40.128.20;2.40.370.10;2.40.128.500;2.40.128.50;2.40.128.180;2.40.128.300;2.40.128.280;2.40.160.20;2.40.128.200;2.40.1...
null
6d02
2019-02-20
other
id:A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f;type:U;source:unknown;length:27;seq_nat:XSKLLELLRKLLEALHKAIELLEKWGX;seq_unnat:(ACE)SKLLELLRKLLEALHKAIELLEKWG(NH2)
2,974.649
P 21 21 2
107.546|107.777|99.374|90.00|90.00|90.00
X-RAY DIFFRACTION
null
S.Q. Zhang;H. Huang;J. Yang;H.T. Kratochvil;M. Lolicato;Y. Liu;X. Shu;L. Liu;W.F. DeGrado
"Designed peptides that assemble into cross-alpha amyloid-like structures", Nat. Chem. Biol., 14, 870-875
10.1038/s41589-018-0105-5|30061717||1552-4469|
US
Cross-alpha amyloid-like structure alphaaml, 2nd form
de novo;protein desidn;coiled-coil;alpha-amyloid;fabril;de novo protein
null
null
6c51(1);6c4y(1);6c4z(1);6c52(1);6c4x(0.9767000079);6o3n(0.9937999845)
null
6d02(0)
null
6c52(1)
null
6.10.250.770;6.10.250.1960;1.20.5.420;1.20.5.2620;1.20.5.1450;6.10.250.1560;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;1.20.5.3960;6.10.250.740;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.400;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.25...
null
6d0t
2018-09-19
other
id:A,B;type:D;source:synthetic construct;length:121;seq_nat:MVDAAQYFPGTWEFRFRSSDGKEYRGTVEMQPRTPTEIEIRFKGQSSDGRPVEGRGSIEVRSPYEYRFEMQSSDGARWEGTLQVRSPDSVEVRFKSSDGREYSGEFRRQEGSLEHHHHHH;seq_unnat:MVDAAQYFPGTWEFRFRSSDGKEYRGTVEMQPRTPTEIEIRFKGQSSDGRPVEGRGSIEVRSPYEYRFEMQSSDGARWEGTLQVRSPDSVEVRFKSSDGREYSGEFRRQEGSLEHHHHHH
14,065.296
P 1 21 1
55.760|32.270|81.650|90.00|100.64|90.00
X-RAY DIFFRACTION
null
J. Dou;A.A. Vorobieva;W. Sheffler;L.A. Doyle;H. Park;M.J. Bick;B. Mao;G.W. Foight;M.Y. Lee;L.A. Gagnon;L. Carter;B. Sankaran;S. Ovchinnikov;E. Marcos;P.S. Huang;J.C. Vaughan;B.L. Stoddard;D. Baker
"De novo design of a fluorescence-activating beta-barrel", Nature, 561, 485-491
10.1038/s41586-018-0509-0|30209393|0006|1476-4687|NATUAS
UK
De novo design of a fluorescence-activating beta barrel - bb1
de novo protein;beta-barrel;design
6czg(74);6czj(70);6czh(68);8ah9(68);6czi(64);6ohh(58)
null
null
null
6czg(74)
null
6czh(0.7892000079)
1jmx(0.7117999792)
2.40.128.350;2.40.128.280;2.40.128.160;2.40.160.90;2.40.128.10;2.40.128.50;3.30.1120.40;2.40.128.240;2.40.128.640;2.40.128.300
null
6d37
2019-03-13
other
id:A;type:U;source:unknown;length:21;seq_nat:XAYAQWLADAGPASAVPPPSX;seq_unnat:(ACE)AYAQWLAD(DAL)GPAS(DAL)(NVA)PPPS(NH2)
1,893.083
null
|||||
SOLUTION NMR
null
K.A. Graham;A. Byrne;R. Son;N.H. Andersen
"Reversing the typical pH stability profile of the Trp-cage", Biopolymers, 110, e23260-e23260
10.1002/bip.23260|30779444|0161|1097-0282|BIPMAA
US
Trp-cage tr16b r16nva : elimination of ph dependent interactions
circular permutant;trp-cage;microprotein;miniprotein;de novo protein
null
null
null
3uc7(0.9581999779)
2jof(34)
null
1l2y(0.8980000019)
3uc7(0.9581999779)
6.10.250.1960;6.10.250.1110;6.10.250.1560
null
6dkm
2018-12-19
other
id:A,C,E,G;type:D;source:synthetic construct;length:79;seq_nat:GSDESDRIRKIVEESDEIVKESRKLAERARELIKESEDKRVSEERNERLLEELLRILDENAELLKRNLELLKEVLYRTR;seq_unnat:GSDESDRIRKIVEESDEIVKESRKLAERARELIKESEDKRVSEERNERLLEELLRILDENAELLKRNLELLKEVLYRTR|id:B,D,F,H;type:U;source:unknown;length:79;seq_nat:GSDEDDELERLLREYHRVLREYEKLLEELRRLYEEY...
9,540.786
P 1 21 1
39.199|74.709|105.257|90.00|92.75|90.00
X-RAY DIFFRACTION
null
Z. Chen;S.E. Boyken;M. Jia;F. Busch;D. Flores-Solis;M.J. Bick;P. Lu;Z.L. VanAernum;A. Sahasrabuddhe;R.A. Langan;S. Bermeo;T.J. Brunette;V.K. Mulligan;L.P. Carter;F. DiMaio;N.G. Sgourakis;V.H. Wysocki;D. Baker
"Programmable design of orthogonal protein heterodimers", Nature, 565, 106-111
10.1038/s41586-018-0802-y|30568301|0006|1476-4687|NATUAS
UK
Dhd131
de novo protein;computational design;coiled-coil;heterodimer
null
null
null
null
6dmp(36)
null
6msq(0.8802000284)
5szg(0.8837000132)
1.10.287.660;1.10.287.3810;6.10.140.1300;1.10.287.70;1.10.287.690;1.10.287.3290;6.10.140.1450;6.10.140.1740;1.10.287.210;1.10.287.310;1.20.20.10;6.10.260.10;1.20.5.730;1.20.85.10;1.10.287.550;6.10.140.1460;1.10.287.610;1.10.287.230;1.10.287.1890;6.10.250.1010;6.10.280.110;6.10.250.190;6.10.140.1720;1.10.287.540;1.10.28...
null
6dlc
2018-12-26
other
id:A;type:D;source:synthetic construct;length:116;seq_nat:MDSDEHLYKLKTFLENLRRHLDRLDKHIKQLRDILSENPEDERVKDAIDLSERSVRIVKTVIKIFEDSVRKKEKRPIDKRDDKELDKLLDTLEKILQTATKIIDDANKLLEYLRR;seq_unnat:MDSDEHLYKLKTFLENLRRHLDRLDKHIKQLRDILSENPEDERVKDAIDLSERSVRIVKTVIKIFEDSVRKKEKRPIDKRDDKELDKLLDTLEKILQTATKIIDDANKLLEYLRR|id:B;type:U;source:u...
13,897.054
P 64
96.885|96.885|27.846|90.00|90.00|120.00
X-RAY DIFFRACTION
null
Z. Chen;S.E. Boyken;M. Jia;F. Busch;D. Flores-Solis;M.J. Bick;P. Lu;Z.L. VanAernum;A. Sahasrabuddhe;R.A. Langan;S. Bermeo;T.J. Brunette;V.K. Mulligan;L.P. Carter;F. DiMaio;N.G. Sgourakis;V.H. Wysocki;D. Baker
"Programmable design of orthogonal protein heterodimers", Nature, 565, 106-111
10.1038/s41586-018-0802-y|30568301|0006|1476-4687|NATUAS
UK
Designed protein dhd1:234_a, designed protein dhd1:234_b
de novo protein;computational design;coiled-coil;heterodimer
6xns(121)
null
null
null
6xns(121)
null
6xns(0.9416999817)
4l0r(0.7057999969)
6.10.250.770;1.20.5.420;1.10.287.660;6.10.250.2070;1.20.1270.410;1.20.5.430;1.20.5.770;1.20.5.1450;1.10.1220.80;6.10.250.810;1.20.1270.20;1.20.5.700;6.10.250.2150;6.10.250.200;6.10.250.2720;1.10.287.210;6.10.250.2060;6.10.250.110;6.10.250.1090;6.10.250.2370;6.10.250.1020;6.10.250.1440;1.20.1270.50;1.20.5.1610;6.10.250....
null
6dlm
2018-12-19
other
id:A;type:D;source:synthetic construct;length:75;seq_nat:GSPRSYLLKELADLSQHLVRLLERLVRESERVVEVLERGEVDEEELKRLEDLHRELEKAVREVRETHREIRERSR;seq_unnat:GSPRSYLLKELADLSQHLVRLLERLVRESERVVEVLERGEVDEEELKRLEDLHRELEKAVREVRETHREIRERSR|id:B;type:U;source:unknown;length:76;seq_nat:GSDREYIIKDILDSQEHLLRLIEELLETQKELLEILKRRPDSVERVRELVRRSKEI...
9,119.329
P 21 21 21
44.918|48.755|64.152|90.00|90.00|90.00
X-RAY DIFFRACTION
null
Z. Chen;S.E. Boyken;M. Jia;F. Busch;D. Flores-Solis;M.J. Bick;P. Lu;Z.L. VanAernum;A. Sahasrabuddhe;R.A. Langan;S. Bermeo;T.J. Brunette;V.K. Mulligan;L.P. Carter;F. DiMaio;N.G. Sgourakis;V.H. Wysocki;D. Baker
"Programmable design of orthogonal protein heterodimers", Nature, 565, 106-111
10.1038/s41586-018-0802-y|30568301|0006|1476-4687|NATUAS
UK
Dhd127
de novo protein;computational design;coiled-coil;heterodimer
null
null
null
null
6dlm(0)
null
5j2l(0.8396000266)
5nfd(0.8644999862)
1.10.287.110;1.20.5.420;1.10.287.660;6.10.140.630;1.10.287.3810;6.10.140.1300;1.10.287.70;6.10.140.790;1.10.287.690;1.10.287.3290;6.10.140.1450;1.10.287.140;1.10.287.210;1.10.287.310;1.20.20.10;6.10.260.10;1.10.287.550;1.20.85.10;6.10.140.1460;1.10.287.610;1.10.287.230;1.10.287.1890;6.10.250.1010;6.10.280.110;6.10.140....
null
6dm9
2018-12-19
other
id:A,C;type:D;source:synthetic construct;length:78;seq_nat:MTREELLRENIELAKEHIEIMREILELLQKMEELLEKARGADEDVAKTIKELLRRLKEIIERNQRIAKEHEYIARERS;seq_unnat:(FME)TREELLRENIELAKEHIEIMREILELLQKMEELLEKARGADEDVAKTIKELLRRLKEIIERNQRIAKEHEYIARERS|id:B,D;type:U;source:unknown;length:78;seq_nat:GTERKLLERSRRLQEESKRLLDEMAEIMRRIKKLLKKARGAD...
9,529.052
P 21 21 21
27.854|92.739|115.333|90.00|90.00|90.00
X-RAY DIFFRACTION
null
Z. Chen;S.E. Boyken;M. Jia;F. Busch;D. Flores-Solis;M.J. Bick;P. Lu;Z.L. VanAernum;A. Sahasrabuddhe;R.A. Langan;S. Bermeo;T.J. Brunette;V.K. Mulligan;L.P. Carter;F. DiMaio;N.G. Sgourakis;V.H. Wysocki;D. Baker
"Programmable design of orthogonal protein heterodimers", Nature, 565, 106-111
10.1038/s41586-018-0802-y|30568301|0006|1476-4687|NATUAS
UK
Dhd15_extended
de novo protein;computational design;coiled-coil;heterodimer
6dma(138)
null
null
null
6dma(138)
null
6dma(0.9244999886)
null
1.20.5.2950;6.10.250.1520;6.10.250.2700;1.20.5.2280;1.10.287.340;1.20.5.4090;6.10.250.990;4.10.93.10;1.20.5.340;1.20.5.730;6.10.250.370;6.10.250.1060;1.20.5.390;1.20.5.1700;1.20.5.190;6.10.250.230;4.10.270.10;6.10.250.2630;1.20.5.530;1.20.5.110;1.20.5.620;1.20.5.1180;6.10.250.1970;1.20.5.1500;1.20.5.1060;6.10.250.780;6...
null
6dma
2018-12-19
other
id:A,C,E,G;type:D;source:synthetic construct;length:78;seq_nat:MTREELLRENIELAKEHIEIMREILELLQKMEELLEKARGADEDVAKTIKELLRRLKEIIERNQRIAKEHEYIARERS;seq_unnat:MTREELLRENIELAKEHIEIMREILELLQKMEELLEKARGADEDVAKTIKELLRRLKEIIERNQRIAKEHEYIARERS|id:B,D,F,H;type:U;source:unknown;length:78;seq_nat:GTERKLLERSRRLQEESKRLLDEMAEIMRRIKKLLKKA...
9,501.041
P 32
57.615|57.615|130.861|90.00|90.00|120.00
X-RAY DIFFRACTION
null
Z. Chen;S.E. Boyken;M. Jia;F. Busch;D. Flores-Solis;M.J. Bick;P. Lu;Z.L. VanAernum;A. Sahasrabuddhe;R.A. Langan;S. Bermeo;T.J. Brunette;V.K. Mulligan;L.P. Carter;F. DiMaio;N.G. Sgourakis;V.H. Wysocki;D. Baker
"Programmable design of orthogonal protein heterodimers", Nature, 565, 106-111
10.1038/s41586-018-0802-y|30568301|0006|1476-4687|NATUAS
UK
Dhd15_closed
de novo protein;computational design;coiled-coil;heterodimer
6dm9(138)
null
null
null
6dm9(138)
null
8d9o(0.8507999778)
5xns(0.8457000256)
1.10.287.110;1.20.5.420;1.10.287.660;1.10.287.3810;6.10.140.1300;1.20.5.1430;1.10.287.70;1.10.287.690;1.10.287.3290;6.10.250.980;1.20.5.3730;1.10.287.210;1.10.287.310;1.20.20.10;1.10.287.550;6.10.230.10;6.10.140.1460;1.10.287.610;1.20.5.290;1.10.287.230;1.10.287.1890;6.10.250.1010;6.10.280.110;6.10.250.190;6.10.140.172...
null
6dmp
2018-12-19
other
id:A;type:D;source:synthetic construct;length:77;seq_nat:GTKEDILERQRKIIERAQEIHRRQQEILEELERIIRKPGSSEEAMKRMLKLLEESLRLLKELLELSEESAQLLYEQR;seq_unnat:GTKEDILERQRKIIERAQEIHRRQQEILEELERIIRKPGSSEEAMKRMLKLLEESLRLLKELLELSEESAQLLYEQR|id:B;type:U;source:unknown;length:83;seq_nat:TEKRLLEEAERAHREQKEIIKKAQELHRRLEEIVRQSGSSEEAKKEAKKILE...
9,344.792
null
|||||
SOLUTION NMR
null
Z. Chen;S.E. Boyken;M. Jia;F. Busch;D. Flores-Solis;M.J. Bick;P. Lu;Z.L. VanAernum;A. Sahasrabuddhe;R.A. Langan;S. Bermeo;T.J. Brunette;V.K. Mulligan;L.P. Carter;F. DiMaio;N.G. Sgourakis;V.H. Wysocki;D. Baker
"Programmable design of orthogonal protein heterodimers", Nature, 565, 106-111
10.1038/s41586-018-0802-y|30568301|0006|1476-4687|NATUAS
UK
De novo design of a protein heterodimer with specificity mediated by hydrogen bond networks
de novo protein;computational design;coiled coil
null
null
null
null
6dmp(0)
null
5j10(0.8421999812)
1l8d(0.8646000028)
1.10.287.660;1.10.287.3810;1.10.287.70;1.10.287.690;1.10.287.3290;6.10.140.1450;6.10.140.1740;1.10.287.140;1.10.287.210;1.10.287.450;1.10.287.310;1.20.20.10;6.10.260.10;1.20.5.730;1.20.85.10;1.10.287.550;6.10.140.1460;1.10.287.610;1.10.287.230;1.10.287.1890;6.10.250.1010;6.10.280.110;6.10.250.190;6.10.140.1720;6.10.140...
null
6ds9
2018-10-03
other
id:A;type:D;source:synthetic construct;length:94;seq_nat:GSWAEFKQRLAAIKTRLAAIKTRLQALGGSEAELAAFEKEIAAFESEIAAFESELQAYKGKGNPEVEALRKEAAAIRDEAAAIRDELQAYRHN;seq_unnat:GSWAEFKQRLAAIKTRLAAIKTRLQALGGSEAELAAFEKEIAAFESEIAAFESELQAYKGKGNPEVEALRKEAAAIRDEAAAIRDELQAYRHN
10,220.457
H 3
46.396|46.396|109.303|90.000|90.000|120.000
X-RAY DIFFRACTION
null
K.J. Koebke;L. Ruckthong;J.L. Meagher;E. Mathieu;J. Harland;A. Deb;N. Lehnert;C. Policar;C. Tard;J.E. Penner-Hahn;J.A. Stuckey;V.L. Pecoraro
"Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein", Inorg Chem, 57, 12291-12302
10.1021/acs.inorgchem.8b01989|30226758|0009|1520-510X|INOCAJ
US
Elongated version of a de novo designed three helix bundle structure (gra3d)
de novo scaffold;de novo protein;three helix bundle
2a3d(117)
2mtq(113)
null
null
2a3d(117)
2mtq(113)
9rgx(0.7200999856)
3uun(0.7210000157)
1.20.58.740;1.20.58.60;1.20.1280.280;1.20.120.400;1.20.58.160;1.20.58.400;1.20.58.1150;1.20.120.30;1.20.58.1800;1.20.58.1360;1.20.58.150;1.20.1440.210;1.20.58.70;1.20.58.200;1.20.1440.60;1.10.287.750;1.20.58.1200;1.20.58.80;1.20.58.220;1.20.1280.20;1.20.58.910;1.20.1280.140;1.20.120.230;1.20.58.340;1.20.1280.290;1.20.5...
null
6e5c
2018-11-07
other
id:A;type:D;source:synthetic construct;length:78;seq_nat:TRETKVTVNPGEEYEVKVNPGTRVEIQAKGPAEFEGGGTRTRLNPGESYKFENLTSQPLRIRLRNLSDTPIEFRIREE;seq_unnat:TRETKVTVNPGEEYEVKVNPGTRVEIQAKGPAEFEGGGTRTRLNPGESYKFENLTSQPLRIRLRNLSDTPIEFRIREE
8,916.916
null
|||||
SOLUTION NMR
null
E. Marcos;T.M. Chidyausiku;A.C. McShan;T. Evangelidis;S. Nerli;L. Carter;L.G. Nivon;A. Davis;G. Oberdorfer;K. Tripsianes;N.G. Sgourakis;D. Baker
"De novo design of a non-local beta-sheet protein with high stability and accuracy", Nat. Struct. Mol. Biol., 25, 1028-1034
10.1038/s41594-018-0141-6|30374087||1545-9985|
US
Solution nmr structure of a de novo designed double-stranded beta-helix
de novo;de novo protein;beta sheet;beta protein
null
null
null
null
8bl6(35)
null
8a1a(0.4726999998)
2gu9(0.7164999843)
2.60.120.380;2.60.40.2410;2.60.120.340;2.60.120.770;2.60.120.1300;2.60.40.290;2.60.120.260;2.60.120.1090;2.60.40.1780;2.60.40.4070;2.60.120.10;2.60.40.1170
null
6e5h
2018-11-21
other
id:A;type:U;source:unknown;length:28;seq_nat:NDKCKELKKRYAGCEVRCDPPRYEVHCX;seq_unnat:NDKCKELKKRY(AIB)GCEVRCD(DPR)PRYEVHC(NH2)
3,260.814
null
|||||
SOLUTION NMR
null
C.C. Cabalteja;D.S. Mihalko;W.S. Horne
"Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein", Chembiochem, 20, 103-110
10.1002/cbic.201800558|30326175||1439-7633|
GE
Heterogeneous-backbone mimics of a designed disulfide-rich protein: aib turn
de novo protein;heterogeneous backbone foldamer
6e5j(68);5kvn(63);6e5k(61);6e5i(60)
null
null
null
6e5j(68)
null
5kvn(0.9110000134)
1wdj(0.7074000239)
null
null
6e5i
2018-11-21
other
id:A;type:U;source:unknown;length:27;seq_nat:NDKCKELKKRYACEVRCDPPRYEVHCX;seq_unnat:NDKCKELKKRY(ORN)CEVRCD(DPR)PRYEVHC(NH2)
3,232.803
null
|||||
SOLUTION NMR
null
C.C. Cabalteja;D.S. Mihalko;W.S. Horne
"Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein", Chembiochem, 20, 103-110
10.1002/cbic.201800558|30326175||1439-7633|
GE
Heterogeneous-backbone mimics of a designed disulfide-rich protein: orn turn
de novo protein;heterogeneous backbone foldamer
6e5h(61);6e5j(61);5kvn(59);6e5k(54)
null
null
null
6e5h(61)
null
6e5h(0.8883000016)
5zcy(0.6588000059)
6.10.250.1990
null
6e5j
2018-11-21
other
id:A;type:U;source:unknown;length:28;seq_nat:NDKCKELKKRYAGCEVRCDPPRYEVHCX;seq_unnat:ND(B3K)CK(B3E)LK(B3K)RY(AIB)GCE(MVA)RCD(DPR)PRYE(MVA)HC(NH2)
3,328.933
null
|||||
SOLUTION NMR
null
C.C. Cabalteja;D.S. Mihalko;W.S. Horne
"Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein", Chembiochem, 20, 103-110
10.1002/cbic.201800558|30326175||1439-7633|
GE
Heterogeneous-backbone mimics of a designed disulfide-rich protein: aib turn, beta3 helix, n-methyl hairpin
de novo protein;heterogeneous backbone foldamer
6e5h(68);5kvn(63);6e5k(61);6e5i(60)
null
null
null
6e5h(68)
null
6e5k(0.8241999745)
2meo(0.611899972)
null
null
6e5k
2018-11-21
other
id:A;type:U;source:unknown;length:28;seq_nat:NDACKALKARYAGCEVRCDPPRYEVHCX;seq_unnat:ND(AIB)CK(AIB)LK(AIB)RY(AIB)GCE(MVA)RCD(DPR)PRYE(MVA)HC(NH2)
3,156.709
null
|||||
SOLUTION NMR
null
C.C. Cabalteja;D.S. Mihalko;W.S. Horne
"Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein", Chembiochem, 20, 103-110
10.1002/cbic.201800558|30326175||1439-7633|
GE
Heterogeneous-backbone mimics of a designed disulfide-rich protein: aib turn, aib helix, n-methyl hairpin
de novo protein;heterogeneous backbone foldamer
6e5h(61);6e5j(61);5kvn(56);6e5i(53)
null
null
null
6e5h(61)
null
6e5h(0.8669999838)
5hd9(0.5503000021)
null
null
6e9t
2018-11-21
other
id:B,A,N,C,O,D,P,E,Q,F,R,G,S,H,T,I,U,J,V,K,W,L,X,M;type:D;source:synthetic construct;length:229;seq_nat:PEVELLRVVMLVKEAEELLTLAVIKGSEDDLQKALRTAVEAAREAVKVLLQAVKRGDPEVALRAVELVVRVAELLLRIAKESGSELALKMALLVAEEAARLAKIVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQ...
25,273.379
null
|||||
ELECTRON MICROSCOPY
null
H. Shen;J.A. Fallas;E. Lynch;W. Sheffler;B. Parry;N. Jannetty;J. Decarreau;M. Wagenbach;J.J. Vicente;J. Chen;L. Wang;Q. Dowling;G. Oberdorfer;L. Stewart;L. Wordeman;J. De Yoreo;C. Jacobs-Wagner;J. Kollman;D. Baker
"De novo design of self-assembling helical protein filaments", Science, 362, 705-709
10.1126/science.aau3775|30409885|0038|1095-9203|SCIEAS
US
Dhf58 filament
filament;protein design;protein fibril
5cwm(314);6e9z(311);6e9y(272);6e9v(266);6xr1(124);6xns(115);8e0n(104);6xr2(102);9dze(94);8fbo(89);8e12(82);8fit(81);8f6r(79);8e0o(78);7udl(77);5cwo(76);5cwj(70);6xh5(70);8fiq(61);8fin(59);8tm9(59);8tlp(59);7rkc(57)
6e9r(63);9k7u(58)
null
null
5cwm(314)
6e9r(63)
5cwm(0.8816999793)
4hwh(0.4722000062)
1.10.287.110;1.10.287.1520;1.25.40.410;1.25.40.90;1.20.58.160;1.20.1440.70;1.10.287.310;1.20.58.150;1.20.58.1910;1.20.1310.30;1.10.287.1890;1.20.58.2150;1.20.58.1440;1.20.58.70;1.20.58.80;1.20.58.600;1.20.58.220;1.20.1280.20;1.20.58.1080;1.20.1310.10;1.20.58.910;1.20.58.2070;6.10.140.590;1.25.40.150;1.20.870.10;1.20.58...
null
6e9v
2018-11-21
other
id:Q,A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,R,S,T,U,V,W,X,Y,Z;type:D;source:synthetic construct;length:213;seq_nat:PEDELKRVEKLVKEAEMLLMLAKIKGSEKDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALMTALLVAVVAATLAVRVLVLAAVQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAQEQGDPVVAIAAVMLVKRVAELLERIARESGSEEAKERAERVREE;...
23,111.928
null
|||||
ELECTRON MICROSCOPY
null
H. Shen;J.A. Fallas;E. Lynch;W. Sheffler;B. Parry;N. Jannetty;J. Decarreau;M. Wagenbach;J.J. Vicente;J. Chen;L. Wang;Q. Dowling;G. Oberdorfer;L. Stewart;L. Wordeman;J. De Yoreo;C. Jacobs-Wagner;J. Kollman;D. Baker
"De novo design of self-assembling helical protein filaments", Science, 362, 705-709
10.1126/science.aau3775|30409885|0038|1095-9203|SCIEAS
US
Dhf79 filament
filament;protein design;protein fibril
6e9z(292);5cwm(286);6e9t(269);6e9y(258);6xr1(121);6xr2(99);9dze(96);6xns(95);8e0n(91);8fbj(89);8e0o(85);5cwn(81);8e0l(77);8f6r(73);8fit(72);8e12(70);8f6q(68);5cwj(64);6xh5(64);8tm9(51);8tlp(51)
null
5cwm(0.9779000282)
null
6e9z(292)
null
5cwm(0.9779000282)
5nz7(0.4763000011)
1.10.287.110;1.10.287.1520;1.25.40.410;6.10.250.2850;1.25.40.90;1.20.58.160;6.10.140.790;6.10.140.480;1.20.1440.70;1.10.287.690;1.10.287.310;1.20.58.150;1.20.58.1910;1.20.1310.30;6.10.140.1480;1.10.287.610;1.10.287.1890;1.10.287.2500;1.20.58.1440;1.20.58.80;1.20.58.600;1.20.58.220;6.10.140.820;1.20.1280.20;1.20.1280.31...
null
6e9y
2018-11-21
other
id:A,B,C,D,E,F,G,H,I,J,K,L,M,N,O;type:D;source:synthetic construct;length:229;seq_nat:AEELLKRVEKLVKEAEELLRQAMKKGSEELLEVALVVAQMAAREAKKVLTMAEVEGDPEVALRAVELVVRVAELLLRIALVSGSEEALERALRVAEEAARLAKRVLELAESQGDPEVALRAVELVVRVAELLLLIAKVSGSEEALERALRVAEEAARLAKRVLELAEKQGDPAVAILAVMLVKRVAELLENIARESGSEEAKERAERVREEARELQERVKELKERAG;seq_un...
25,066.168
null
|||||
ELECTRON MICROSCOPY
null
H. Shen;J.A. Fallas;E. Lynch;W. Sheffler;B. Parry;N. Jannetty;J. Decarreau;M. Wagenbach;J.J. Vicente;J. Chen;L. Wang;Q. Dowling;G. Oberdorfer;L. Stewart;L. Wordeman;J. De Yoreo;C. Jacobs-Wagner;J. Kollman;D. Baker
"De novo design of self-assembling helical protein filaments", Science, 362, 705-709
10.1126/science.aau3775|30409885|0038|1095-9203|SCIEAS
US
Dhf38 filament
filament;protein design;protein fibril
5cwm(301);6e9z(280);6e9t(271);6e9v(254);6xr1(122);6xns(105);9dze(102);8fbj(102);6xr2(100);8e0n(99);8flx(87);8e12(80);8e0o(78);8f6q(77);8fit(77);8fbo(74);8tm9(68);8tlp(68);7rkc(66);8f6r(60);6xss(59);5cwp(57);5cwq(53);8fin(51);8fiq(50)
null
null
null
5cwm(301)
9drl(46)
6e9z(0.8359000087)
1w99(0.4607999921)
1.10.287.1520;1.25.40.410;1.25.40.90;1.20.58.160;1.20.1440.70;1.20.58.1190;1.20.1310.30;1.10.287.1890;1.20.58.80;1.20.58.600;1.20.58.220;1.20.1280.20;1.20.58.1080;1.20.1310.10;1.25.40.810;1.20.58.910;1.20.58.2070;6.10.140.590;1.20.58.240;1.20.870.10;1.20.58.310;1.10.1240.10;1.20.120.420;1.20.58.1280;1.25.40.240;1.20.58...
null
6e9z
2018-11-21
other
id:B,A,C,F,D,H,G,E,I;type:D;source:synthetic construct;length:227;seq_nat:PEDELKRVEKLVKEAEALLIVAKIKGSKRDLEKALRTAEEAAREAVKVLVQALLEGDPEVALRAVELVVRVAELLLRIAKESGSREALLRALIVAEEAAKLAKMVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEEQGDPLVAKMAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER;seq_unnat:PEDELKRVEK...
25,120.242
null
|||||
ELECTRON MICROSCOPY
null
H. Shen;J.A. Fallas;E. Lynch;W. Sheffler;B. Parry;N. Jannetty;J. Decarreau;M. Wagenbach;J.J. Vicente;J. Chen;L. Wang;Q. Dowling;G. Oberdorfer;L. Stewart;L. Wordeman;J. De Yoreo;C. Jacobs-Wagner;J. Kollman;D. Baker
"De novo design of self-assembling helical protein filaments", Science, 362, 705-709
10.1126/science.aau3775|30409885|0038|1095-9203|SCIEAS
US
Dhf119 filament
filament;protein design;protein fibril
5cwm(315);6e9t(310);6e9v(288);6e9y(280);6xr1(122);8fbj(112);6xr2(100);9dze(99);8e0n(98);6xns(98);8fbo(88);8e0o(87);8e0l(79);8f6r(78);8e12(76);5cwj(68);7rkc(56);7unj(55);6n4n(55);8vx7(52)
6e9r(53);9drl(50)
null
null
5cwm(315)
6e9r(53)
5cwm(0.8643000126)
6e9r(0.4706999958)
1.25.40.410;1.25.40.90;1.20.58.160;1.20.1440.70;1.20.58.1190;1.20.58.150;1.20.1310.30;1.20.120.1940;1.20.58.1440;1.20.58.70;1.20.58.80;1.20.58.600;1.20.58.220;1.20.1280.20;1.20.58.1080;1.20.1310.10;1.20.58.910;1.20.58.2070;6.10.140.590;1.20.58.240;1.20.870.10;1.25.40.150;1.20.58.310;1.20.58.1250;1.10.1240.10;1.10.287.1...
null
6ee5
2018-08-29
other
id:A;type:D;source:synthetic construct;length:383;seq_nat:MHHHHHHENLYFQGAASSHKLAEANTDFAFSLYRELAKSSPDKNIFFSPVSISSALAMLSLGAKGDTHTQILEGLGFNSEADIHQGFQHLLQTLNRPKGLQLKTANGLFVDKSLKLLDSFLEDSKKLYQAEAFSVDFDPEEAKKQINDWVEKQTNGKIKDLLKDLDSDTVLVLVNAIYFKGKWKKPFDPENTKEEDFHVDEKTTVKVPMMSQKGKFYYYHDDELSCKVLELPYKGNASMLIILPDEGGLQHLEQSLTPETLS...
42,741.586
C 2 2 21
68.060|75.280|150.450|90.00|90.00|90.00
X-RAY DIFFRACTION
null
E.M. Marijanovic;J. Fodor;B.T. Riley;B.T. Porebski;M.G.S. Costa;I. Kass;D.E. Hoke;S. McGowan;A.M. Buckle
"Reactive centre loop dynamics and serpin specificity", Sci Rep, 9, 3870-3870
10.1038/s41598-019-40432-w|30846766||2045-2322|
UK
Reactive centre loop dynamics and serpin specificity
protein engineering;de novo protein;protein dynamics
null
5cdx(744);5cdz(744);5ce0(743);1kct(445);5nbu(443);8r13(443);4pyw(443);1atu(441);5nbv(441);1hp7(441);1oo8(441);1oph(441);8r21(441);8qz5(441);3ne4(441);1iz2(440);3cwl(440);3cwm(440);2qug(440);1qlp(440);3drm(440);3dru(439);1psi(438);3t1p(436);5io1(436);2d26(398);1ezx(395);9api(395);8api(395);7api(395);5hgc(392);9hud(391);...
null
5cdx(0.9927999973);5ce0(0.9728999734)
9epa(44)
5cdx(744)
6xeh(0.3023000062)
5cdx(0.9927999973)
3.30.497.10;2.30.39.10
null
6egc
2019-05-29
other
id:A;type:D;source:synthetic construct;length:157;seq_nat:GSHMTRTEIIRELERSLREQEELAKRLKELLRELERLQREGSSDEDVRELLREIKELVEEIEKLAREQKYLVEELKRQQGPPGNEIIRELERSLREQEELAKRLKELLRELERLQREGSSDEDVRELLREIKELVEEIEKLAREQKYLVEELKRQD;seq_unnat:GSHMTRTEIIRELERSLREQEELAKRLKELLRELERLQREGSSDEDVRELLREIKELVEEIEKLAREQKYLVEELKRQQGPPGNEIIRELERSLR...
19,030.6
P 1 21 1
41.253|49.360|41.239|90.00|104.30|90.00
X-RAY DIFFRACTION
null
Z. Chen;M.C. Johnson;J. Chen;M.J. Bick;S.E. Boyken;B. Lin;J.J. De Yoreo;J.M. Kollman;D. Baker;F. DiMaio
"Self-Assembling 2D Arrays with de Novo Protein Building Blocks", J.Am.Chem.Soc., 141, 8891-8895
10.1021/jacs.9b01978|31050411||1520-5126|JACSAT
US
Single-chain version of 2l4hc2_23 (pdb 5j0k)
helical bundle;de novo protein;computational design;coiled-coil
5j0k(130);8cwy(99);6b87(86);8cws(68)
9drl(51)
null
null
5j0k(130)
9drl(51)
8tnb(0.7659000158)
8w6f(0.6108999848)
6.10.250.770;6.10.250.3050;1.20.5.420;1.20.5.930;6.10.250.2070;1.20.120.870;1.20.5.430;6.10.250.810;1.20.1270.410;1.20.5.1450;1.20.58.400;1.20.5.750;1.10.8.930;1.20.5.700;1.20.120.330;1.20.58.410;1.20.120.20;6.10.250.2150;6.10.250.2720;1.10.287.210;6.10.250.2060;1.20.120.470;1.20.120.30;1.20.5.520;6.10.250.1020;6.10.25...
null
6egl
2019-04-03
other
id:A;type:U;source:unknown;length:36;seq_nat:EWEALEKKLAALESKCQALEKKLQALEKKLEALEHG;seq_unnat:EWEALEKKLAA(DLE)ESKCQALEKKLQALEKKLEALEHG
4,114.8
H 3 2
38.213|38.213|140.655|90.000|90.000|120.000
X-RAY DIFFRACTION
null
L. Ruckthong;J.A. Stuckey;V.L. Pecoraro
"How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation", Chemistry, 25, 6773-6787
10.1002/chem.201806040|30861211||0947-6539|
GE
Crystal structure of a de novo three-stranded coiled coil peptide containing a d-leu in the second coordination sphere of a non-metalated tris-thiolate binding site
de novo three-stranded coiled coil peptide;engineered protein by d-amino acids;d-leu;tris-thiolate binding site;de novo protein
6egm(69);6egn(69);7n2y(67);5kb2(67);6egp(67);7n2z(67);6ego(67);5kb0(66);5kb1(66);6mcd(63);5u9t(51);5u9u(51);5k92(51)
null
5kb2(1);6egm(0.9991999865);7n2z(1);6egp(1);6egn(1);6ego(0.993900001);7n2y(0.9962999821);6mcd(1);5kb0(0.9925000072);5kb1(0.9735000134)
null
6egm(69)
null
5kb2(1)
null
6.10.250.770;1.20.5.420;1.20.5.930;6.10.250.2070;1.20.5.430;6.10.250.810;1.20.5.770;1.20.5.1450;1.20.5.750;1.20.5.700;6.10.250.2150;6.10.250.2720;1.10.287.210;6.10.250.2060;6.10.250.110;6.10.250.1090;6.10.250.270;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.850;6.10.250.380;6.10.250.2230;1.20.5.110;1.20...
null
6egm
2019-04-03
other
id:A;type:U;source:unknown;length:36;seq_nat:EWEALEKKLAALESKCQALEKKLQALEKKLEALEHG;seq_unnat:EWEALEKKLAALESKCQA(DLE)EKKLQALEKKLEALEHG
4,114.8
H 3 2
37.898|37.898|140.667|90.000|90.000|120.000
X-RAY DIFFRACTION
null
L. Ruckthong;J.A. Stuckey;V.L. Pecoraro
"How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation", Chemistry, 25, 6773-6787
10.1002/chem.201806040|30861211||0947-6539|
GE
Crystal structure of a de novo three-stranded coiled coil peptide containing d-leu in a d-site position of a tris-thiolate binding site
metalloprotein;d-amino acids;three-stranded coiled coil peptide;d-leu;de novo protein;engineered protein
6egl(69);6egn(69);7n2y(67);5kb2(67);6egp(67);7n2z(67);6ego(67);5kb0(66);5kb1(66);6mcd(63);5u9t(51);5u9u(51);5k92(51)
null
6egl(0.9991999865);5kb2(1);6egp(1);7n2z(1);6egn(0.9980999827);6ego(0.9975000024);7n2y(0.9950000048);6mcd(1);5kb0(0.9930999875);5kb1(0.9692000151)
null
6egl(69)
null
5kb2(1)
null
6.10.250.770;1.20.5.420;6.10.250.2070;1.20.5.430;6.10.250.810;1.20.5.1450;1.20.5.750;1.20.5.700;6.10.250.2150;6.10.250.2720;1.10.287.210;6.10.250.2060;6.10.250.1090;6.10.250.270;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.850;6.10.250.380;6.10.250.2230;1.20.5.110;1.20.5.250;1.20.5.160;1.20.5.580;6.10.2...
null
6egn
2019-04-03
other
id:A,B,C;type:U;source:unknown;length:38;seq_nat:XEWEALEKKLAALESKCQALEKKLQALEKKLEALEHGX;seq_unnat:(ACE)EWEALEKKLAALESKCQA(DLE)EKKLQALEKKLEALEHG(NH2)
4,138.846
P 21 21 21
32.636|80.508|88.730|90.000|90.000|90.000
X-RAY DIFFRACTION
null
L. Ruckthong;J.A. Stuckey;V.L. Pecoraro
"How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation", Chemistry, 25, 6773-6787
10.1002/chem.201806040|30861211||0947-6539|
GE
Crystal structure of a three-stranded coiled coil peptide containing a trigonal planar hg(ii)s3 site modified by d-leu in the second coordination sphere
hg(ii)s3 complex;de novo three-stranded helical coiled coil peptide;trigonal planar hg(ii) structure;d-amino acids;d-leu;de novo protein
6egl(69);6egm(69);7n2y(67);5kb2(67);6egp(67);7n2z(67);6ego(67);5kb0(66);5kb1(66);6mcd(63);5u9t(51);5u9u(51);5k92(51)
null
5kb2(0.9933999777);6egl(0.9929000139);6egm(0.9887999892);6egp(0.9894000292);7n2z(0.9911000133);6ego(0.9839000106);7n2y(0.9854999781);5kb0(0.9952999949);6mcd(0.9927999973);5kb1(0.9824000001)
null
6egl(69)
null
5kb0(0.9952999949)
null
6.10.250.770;1.20.5.420;6.10.250.2070;1.20.5.430;6.10.250.810;1.20.5.1450;1.20.5.750;1.20.5.700;6.10.250.2150;6.10.250.200;6.10.250.2720;1.10.287.210;6.10.250.2060;6.10.250.1090;6.10.250.270;1.20.5.520;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.950;6.10.250.850;6.10.250.380;1.20.5.110;1.20.5.250;1.20....
null
6ego
2019-04-03
other
id:A;type:U;source:unknown;length:36;seq_nat:EWEALEKKLAAAESKCQALEKKLQALEKKLEALEHG;seq_unnat:EWEALEKKLAAAESKCQALEKKLQALEKKLEALEHG
4,072.72
H 3 2
38.186|38.186|142.345|90.000|90.000|120.000
X-RAY DIFFRACTION
null
L. Ruckthong;J.A. Stuckey;V.L. Pecoraro
"How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation", Chemistry, 25, 6773-6787
10.1002/chem.201806040|30861211||0947-6539|
GE
Crystal structure of a de novo three-stranded coiled coil peptide containing an ala residue in the second coordination sphere of the hg(ii)s3 binding site
de novo three-stranded helical coiled coil peptide;de novo protein;tris-thiolate hg(ii) complex;trigonal planar hg(ii)s3
5kb2(69);6egp(69);6egl(67);6egm(67);6egn(67);7n2y(65);7n2z(65);5kb0(64);5kb1(64);6mcd(63)
null
5kb2(0.9965000153);6egp(0.9951999784);6egl(0.9932000041);6egm(0.997699976);7n2y(0.9955000281);6egn(0.9975000024);7n2z(0.9904000163);5kb0(0.9871000051);6mcd(0.9858000278);5kb1(0.9677000046)
null
5kb2(69)
null
6egm(0.997699976)
null
6.10.250.770;1.20.5.420;1.20.5.930;6.10.250.2070;1.20.5.430;6.10.250.810;1.20.5.1450;1.20.5.750;1.20.5.700;6.10.250.2720;1.10.287.210;6.10.250.2060;6.10.250.110;6.10.250.1090;1.20.5.520;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.2110;6.10.250.850;6.10.250.380;6.10.250.2230;1.20.5.110;1.20.5.250;1.20.5...
null
6egp
2020-02-26
other
id:A;type:U;source:unknown;length:36;seq_nat:EWEALEKKLAAAESKCQALEKKLQALEKKLEALEHG;seq_unnat:EWEALEKKLAAAESKCQALEKKLQALEKKLEALEHG
4,072.72
H 3 2
37.726|37.726|140.042|90.000|90.000|120.000
X-RAY DIFFRACTION
null
L. Ruckthong;J.A. Stuckey;V.L. Pecoraro
To be published
||||
null
Crystal structure of a trigonal pyramidal pb(ii)s3 complex in a three-stranded coiled coil peptide
de novo three-stranded coiled coil peptide;tris-thiolate;metalloprotein;de novo protein;trigonal pyramidal pb(ii)s3
5kb2(69);6ego(69);6egl(67);6egm(67);6egn(67);7n2y(65);7n2z(65);5kb0(64);5kb1(64);6mcd(63)
null
5kb2(1);6ego(0.9950000048);6egl(1);6egm(1);6egn(1);7n2z(1);7n2y(0.9937999845);5kb0(0.992200017);6mcd(1);5kb1(0.970600009)
null
5kb2(69)
null
5kb2(1)
null
6.10.250.770;1.20.5.420;6.10.250.1610;6.10.250.2070;1.20.5.930;1.20.5.430;6.10.250.810;1.20.5.1450;1.20.5.750;1.20.5.700;6.10.250.2720;1.10.287.210;6.10.250.2060;6.10.250.110;6.10.250.1090;1.20.5.520;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.80;6.10.250.850;6.10.250.2110;6.10.250.380;6.10.250.2230;1....
null
6eik
2018-07-18
other
id:A,B,C,D,E,F,G;type:U;source:unknown;length:32;seq_nat:XGEIAKALREIAKALREIAWALREEAKALRGX;seq_unnat:(ACE)GEIAKALREIAKALREIAWALREEAKALRG(NH2)
3,364.985
P 42 21 2
62.210|62.210|108.680|90.00|90.00|90.00
X-RAY DIFFRACTION
null
F. Thomas;W.M. Dawson;E.J.M. Lang;A.J. Burton;G.J. Bartlett;G.G. Rhys;A.J. Mulholland;D.N. Woolfson
"De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules", ACS Synth Biol, 7, 1808-1816
10.1021/acssynbio.8b00225|29944338||2161-5063|
US
A de novo designed heptameric coiled coil cc-hept-i24e
de novo protein;alpha-helical coiled-coil barrel
null
null
5ezc(1);7nfn(1);5eze(1);5ez9(1);5f2y(0.9929000139);7nfk(1);4pna(1);7bim(1);7nfl(1);5ez8(1);7nfj(1);8a09(0.996999979);4pn9(1);6eiz(1);8b15(1);8b16(0.9962999821);5eza(1);6xy1(1);6zt1(1);6g6f(0.9990000129);7a1t(0.9965999722);7bas(0.9986000061);7qwe(0.9990000129);7nfo(1);7qwb(0.9990000129);7qwd(0.9951000214);7nfp(1);7bav(1...
null
6eik(0)
null
5ezc(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;6.10.250.270;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2720;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110...
null
6eiz
2018-07-11
other
id:A,B,C,D,E,F;type:U;source:unknown;length:32;seq_nat:XGEIAKSLKEIAKSLKEIAWSLKEIAKSLKGX;seq_unnat:(ACE)GEIAKSLKEIAKSLKEIAWSLKEIAKSLKG(NH2)
3,300.973
C 2 2 21
59.080|126.230|58.240|90.00|90.00|90.00
X-RAY DIFFRACTION
null
F. Thomas;W.M. Dawson;E.J.M. Lang;A.J. Burton;G.J. Bartlett;G.G. Rhys;A.J. Mulholland;D.N. Woolfson
"De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules", ACS Synth Biol, 7, 1808-1816
10.1021/acssynbio.8b00225|29944338||2161-5063|
US
A de novo designed hexameric coiled coil cc-hex2 with farnesol bound in the channel
de novo protein;alpha-helical coiled-coil barrel
null
null
4pn9(1);8a09(1);8b16(0.9986000061);8b15(0.9972000122);7bas(1);7bim(0.9984999895);7bav(1);7a1t(1);4pna(1);7qwe(1);7qwb(1);7qwd(1);6xy1(1);5ez8(0.9973000288);7nfj(1);7nfk(1);6g6f(1);7bat(0.9961000085);7qwa(0.9987999797);7baw(1);7nfo(1);5ez9(0.9990000129);6eik(0.9990000129);7bau(0.9970999956);6g6d(0.9966999888);7nfn(1);7n...
null
6eiz(0)
null
4pn9(1)
null
null
null
6f0q
2018-03-21
other
id:A,B;type:D;source:synthetic construct;length:259;seq_nat:GSHMSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAG;seq...
25,857.506
P 1 21 1
47.010|70.350|58.210|90.00|100.60|90.00
X-RAY DIFFRACTION
null
H. Noguchi;B. Mylemans;E. De Zitter;L. Van Meervelt;J.R.H. Tame;A. Voet
"Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies", Biochem. Biophys. Res. Commun., 497, 1038-1042
10.1016/j.bbrc.2018.02.168|29481797|0146|1090-2104|BBRCA9
US
Crystal structure of pizza6-ayw
de novo protein;beta propeller;artificial protein
6i3b(502);6f0s(501);7zq2(498);7zqg(498);7zcj(496);6reh(492);6qsf(492);6rei(492);7ov7(492);6qsg(492);6qsh(492);6reg(492);6qsd(492);7zpz(492);6qse(492);7zpw(490);6i37(488);6rej(486);6rek(486);6f0t(486);6rem(486);6rel(486);6i3a(483);6i38(482);7zph(482);6i39(462);6reo(461);6rlh(461);6rli(461);6ren(461);4zcn(163);5f53(163);...
1rwi(329);1rwl(329);2z2p(91);2z2n(89);2z2o(89);2qc5(87);3v64(57);3v65(57);5gje(53);5fww(53);3s8v(53);3s8z(53);4a0p(53);3s2k(53);9g41(52);9g2h(52);9g2f(52);9g42(51)
7zpw(0.9684000015);6reg(0.9523000121);6rei(0.9588999748);6reo(0.9596999884);6qsg(0.9602000117);7zqg(0.9563999772);6rli(0.9509999752)
null
6i3b(502)
1rwi(329)
7zpw(0.9684000015)
1rwl(0.8737000227)
2.40.10.500;2.20.25.400;2.40.128.190;2.40.10.360;2.20.25.650;2.40.128.630;2.20.25.10;2.30.30.660
null
6f0s
2018-03-21
other
id:A;type:D;source:synthetic construct;length:259;seq_nat:GSHMSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAG;seq_u...
25,788.4
P 1 21 1
33.710|69.910|46.940|90.00|107.23|90.00
X-RAY DIFFRACTION
null
H. Noguchi;B. Mylemans;E. De Zitter;L. Van Meervelt;J.R.H. Tame;A. Voet
"Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies", Biochem. Biophys. Res. Commun., 497, 1038-1042
10.1016/j.bbrc.2018.02.168|29481797|0146|1090-2104|BBRCA9
US
Crystal structure of pizza6-syw
de novo protein;beta propeller;artificial protein
6f0q(499);6reh(497);6qsf(497);6rei(497);7ov7(497);6qsg(497);6qsh(497);6reg(497);6qsd(497);6qse(497);6i3b(492);6rej(492);6rek(492);6f0t(492);6rem(492);6rel(492);7zq2(488);7zqg(488);7zcj(485);7zpz(481);7zpw(480);6i37(478);6i3a(473);6i38(472);7zph(471);6reo(467);6rlh(467);6rli(467);6ren(467);6i39(454);4zcn(165);5f53(165);...
1rwi(334);1rwl(334);2z2p(80);2z2n(78);2z2o(78);2qc5(77);3v64(59);3v65(59);9g41(58);9g2h(58);9g2f(58);5gje(57);5fww(57);3s8v(57);3s8z(57);4a0p(57);3s2k(57);9g42(57)
6qse(0.9764999747);7zcj(0.9843000174);6qsg(0.9671000242);6rli(0.9623000026);6reo(0.9549000263);6rei(0.9628000259);3ww9(0.9589999914);6reg(0.9584000111);6reh(0.9585000277);7zpw(0.9657999873);7ov7(0.950600028);7zph(0.9574999809);6qsf(0.9575999975);7zpz(0.9545000196);6rlh(0.9534000158)
null
6f0q(499)
1rwi(334)
7zcj(0.9843000174)
1rwl(0.8680999875)
2.40.10.500;2.20.25.400;2.40.128.190;2.40.10.360;2.20.25.650;2.40.10.300;2.40.128.630;2.30.30.660
null
6f0t
2018-03-21
other
id:A,B,C;type:D;source:synthetic construct;length:259;seq_nat:GSHMSNTQTVLPWTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPWTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPWTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAG;s...
25,836.4
P 1
32.529|69.454|78.710|65.36|89.80|77.16
X-RAY DIFFRACTION
null
H. Noguchi;B. Mylemans;E. De Zitter;L. Van Meervelt;J.R.H. Tame;A. Voet
"Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies", Biochem. Biophys. Res. Commun., 497, 1038-1042
10.1016/j.bbrc.2018.02.168|29481797|0146|1090-2104|BBRCA9
US
Crystal structure of pizza6-sfw
de novo protein;beta propeller;artificial protein
6reh(497);6qsf(497);6rei(497);7ov7(497);6qsg(497);6qsh(497);6reg(497);6qsd(497);6qse(497);6rej(492);6rek(492);6rem(492);6rel(492);6f0s(490);7zq2(488);7zqg(488);7zcj(485);6f0q(483);7zpz(481);7zpw(480);6i3b(475);7zph(471);6reo(467);6rlh(467);6rli(467);6ren(467);6i37(461);6i38(457);6i3a(456);6i39(438);4zcn(165);5f53(165);...
1rwi(334);1rwl(334);3v64(64);3v65(64);5gje(64);5fww(64);3s8v(64);3s8z(64);4a0p(64);3s2k(64);9g2h(61);9g42(60);9g41(60);9g2f(60);3soq(53);3sov(53);3sob(52);4dg6(52);3s94(52);1l0q(51)
6rei(0.956799984);6qsg(0.9602000117);6rel(0.9517999887);6reg(0.956099987);7ov7(0.9549000263);7zpw(0.962199986);6reh(0.9559000134)
null
6reh(497)
1rwi(334)
7zpw(0.962199986)
1rwi(0.8744999766)
2.40.10.500;2.40.128.190;2.40.128.660;2.20.25.650;2.40.128.630;2.40.128.650
null
6fes
2018-09-05
other
id:A,B,C,D;type:D;source:synthetic construct;length:371;seq_nat:GPGSDLGKKLLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKNGADARAQDKFGKTPEDLARDNGYESVARLARKEIIRAVVDELKELIQNVNDDIKEVEKNPEDMEYWNKIYRLVHTMKEITETMGFSPVALVLEAIMMLVKLMLNSEIKITSDLIDAVKKMLDMVTRLLD...
41,061.582
P 1
52.990|63.000|133.540|97.99|91.92|110.81
X-RAY DIFFRACTION
null
M. ElGamacy;M. Coles;P. Ernst;H. Zhu;M.D. Hartmann;A. Pluckthun;A.N. Lupas
"An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture", ACS Synth Biol, 7, 2226-2235
10.1021/acssynbio.8b00224|30148951||2161-5063|
US
Crystal structure of novel repeat protein bric2 fused to darpin d12
de novo protein;novel fold;computational design;corrugated repeat
6sa6(314);6sa7(304);5le6(301);5le8(301);5leb(301);5le2(301);5le7(298);6sa8(297);5le3(295);5lee(294);5led(294);5lec(294);5le4(293);5lw2(288);7dne(283);5le9(244);6fp9(241);5lea(240);7z7e(239);5op3(239);6fpa(237);7b4t(237);6fpb(237);4ydw(237);7b4w(235);5kng(234);5knh(234);9gtk(233);7z7c(231);9ivp(231);5oos(230);5oou(229);...
6f5e(302);5aq7(282);5lw1(261);5lel(247);5mad(240);5aq9(239);5aqb(239);5ma6(238);5ma8(238);5fin(238);5fio(238);5ma4(238);5mak(238);5ma3(238);5ma5(238);5ma9(238);5lem(238);4ydy(237);5aq8(237);1svx(234);5oyj(232);2y1l(232);5op1(231);3noc(230);4k5b(230);5aqa(230);5oov(228);4f6r(228);3nog(228);4hna(228);4hrm(227);5enr(226);...
9epa(0.9503999949)
null
6sa6(314)
6f5e(302)
9epa(0.9503999949)
5fin(0.940500021)
1.20.120.160;1.20.1440.140;1.20.120.310;1.20.1280.280;1.20.120.360;1.25.10.10;1.25.40.420;1.20.120.290;1.20.58.810;1.20.120.330;1.20.1280.250;1.20.120.580;1.20.1440.50;1.20.58.1150;1.25.40.750;1.20.120.30;1.10.167.10;1.20.1270.430;1.20.120.960;1.20.120.260;1.25.40.580;1.20.1440.210;1.20.58.930;1.20.1270.90;1.20.58.120;...
null
6ff6
2018-09-05
other
id:A;type:D;source:synthetic construct;length:252;seq_nat:MGSSHHHHHHSSGLVPRGSHMFYQTFFDEADELLADMEQHLLDLVPESPDAEQLNAIFRAAHSIKGGAGTFGFTMLQYAVELMENMLDFARRGEMQLNTDIINLFLELKDLMQRMLDYYKNKPQSFYQAFFDMADVMLKVMEQLLKLLVPESPDAAMLNAIFRAAHFIKGAAGTFGFTILQETTHLMENLLDEARRGEMQLNTDIINLFLETKDIMQEQLDAYKNSEEPDAASFEYICNALRQLALEAK;seq_unnat:MG...
28,491.473
C 1 2 1
113.661|41.953|58.263|90.00|90.46|90.00
X-RAY DIFFRACTION
null
M. ElGamacy;M. Coles;P. Ernst;H. Zhu;M.D. Hartmann;A. Pluckthun;A.N. Lupas
"An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture", ACS Synth Biol, 7, 2226-2235
10.1021/acssynbio.8b00224|30148951||2161-5063|
US
Crystal structure of novel repeat protein bric1
de novo protein;novel fold;computational design;corrugated repeat
7m0q(55);8c66(51);8adx(51);7k3h(50);6y07(50)
1i5n(215);2lp4(213);1t57(58);2ix1(58);3ssm(57);3ssn(57);3sso(57);3cp2(57);4u3e(57);2oba(56);3l20(56);2i22(56);2i2w(56);4r9v(56);2i4l(56);2i4m(56);2i4n(56);2i4o(56);3zmd(55);5e1l(55);8vab(55);8vag(55);8va9(55);8vai(55);4lbd(55);3lbd(55);2lbd(55);8z1i(55);4txd(55);3vax(55);4uqa(55);5a6m(55);4uqb(55);4uqc(55);4uqd(55);4uq...
null
null
7m0q(55)
1i5n(215)
7t2y(0.7947999835)
1i5n(0.8496999741)
1.20.120.160;1.20.1440.140;1.20.120.310;1.20.1280.280;1.20.120.400;1.20.120.360;1.20.120.290;1.20.58.810;1.20.1270.20;1.20.120.20;1.20.120.330;1.20.1280.250;1.20.120.580;1.20.1440.50;1.20.58.1150;1.20.120.470;1.20.120.30;1.20.120.960;1.20.1270.430;1.20.120.260;1.20.1440.210;1.20.1270.90;1.10.3450.10;1.20.120.50;1.20.58...
null
6fp9
2018-10-03
other
id:B,A;type:D;source:synthetic construct;length:184;seq_nat:MRGSHHHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNATDWVGMTPLHLAAWKGHLEIVEVLLKTGADVNAHDVFGTTPLHLAAHRGHLEIVEVLLKAGADVNAQDMVGKTPLHLAAYYGHLEIVEVLLKHGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAAKLNDYKDDDDK;seq_unnat:MRGSHHHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNATDWVGMTPLHLAAWKGHLEIVEV...
19,879.373
P 1 21 1
51.746|91.597|54.410|90.00|116.93|90.00
X-RAY DIFFRACTION
null
M.A. Vigano;D. Bieli;J.V. Schaefer;R.P. Jakob;S. Matsuda;T. Maier;A. Pluckthun;M. Affolter
"DARPins recognizing mTFP1 as novel reagents forin vitroandin vivoprotein manipulations", Biol Open, 7
10.1242/bio.036749|30237292||2046-6390|
UK
Crystal structure of anti-mtfp1 darpin 1238_e11
de novo protein;protein binder;designed ankyrin repeat proteins;darpin
8u1b(327);9dmi(327);6fpa(299);6fpb(299);9gtk(296);7b4w(286);7z7c(286);7b4t(284);7zyu(282);5kng(281);5knh(281);9fe2(280);9fe3(280);5op3(279);8ql6(279);8ql5(279);8ql9(279);9u6a(279);8ql2(279);8ql3(279);9f8g(279);8qlb(279);8qla(279);8ql7(279);8ql8(279);8qea(279);8ql4(279);4dui(279);7z7e(278);5oou(278);2bkg(277);4j7w(277);...
6fp8(375);6fp7(334);4hrm(297);4k5b(296);5fin(292);5fio(292);4k5a(287);4hrl(287);2p2c(286);5aqb(286);5op1(285);5aq8(285);3nog(282);5enr(280);5nc5(280);4dx6(280);4u96(280);5ens(280);4dx7(280);4u8v(280);5en5(280);5jmn(280);9fhc(280);3zu7(280);5ent(280);4u8y(280);5eno(280);2j8s(280);5enp(280);9fhg(280);9fhj(280);5enq(280);...
6fpb(0.9726999998);6fpa(0.9700999856);9gtk(0.9818000197);7b4w(0.969900012);7b4t(0.9581999779);7z7e(0.9710999727);2xeh(0.9674999714);7zyu(0.9549000263);5kng(0.9532999992);7z7c(0.962100029);7z71(0.9542000294);5le8(0.9624000192);2xee(0.9648000002);5knh(0.951300025);1mj0(0.9573000073);4ydw(0.9526000023);8aed(0.9532999992);...
6fp8(0.9782000184);6fp7(0.9667000175);5fin(0.9660000205);5aq9(0.9635000229);5ma9(0.9714000225);4k5a(0.9696999788);5ma8(0.951399982);5aq8(0.9556999803);5ma5(0.9641000032);4k5b(0.9545000196);4ydy(0.9556000233);5ma4(0.9535999894);4jb8(0.9545000196);5aq7(0.9534999728)
8u1b(327)
6fp8(375)
9gtk(0.9818000197)
6fp8(0.9782000184)
1.10.10.10;1.10.10.2400;1.25.40.70;1.10.220.10;1.20.970.10;1.25.10.10;1.25.40.20
null
6fpa
2018-10-03
other
id:A,B;type:D;source:synthetic construct;length:166;seq_nat:GPGSDLGKKLLEAARAGQDDEVRILMANGADVNAEDWMGATPLHLAAQSGHLEIVEVLLKTGADVNAHDAFGWTPLHLAASQGHLEIVEVLLKAGADVNATDMVGRTPLHLAARRGHLEIVEVLLKHGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAAKLN;seq_unnat:GPGSDLGKKLLEAARAGQDDEVRILMANGADVNAEDWMGATPLHLAAQSGHLEIVEVLLKTGADVNAHDAFGWTPLHLAASQGHL...
17,364.582
P 21 21 21
37.990|89.156|103.838|90.00|90.00|90.00
X-RAY DIFFRACTION
null
M.A. Vigano;D. Bieli;J.V. Schaefer;R.P. Jakob;S. Matsuda;T. Maier;A. Pluckthun;M. Affolter
"DARPins recognizing mTFP1 as novel reagents forin vitroandin vivoprotein manipulations", Biol Open, 7
10.1242/bio.036749|30237292||2046-6390|
UK
Crystal structure of anti-mtfp1 darpin 1238_g01 in space group p212121
de novo protein;protein binder;designed ankyrin repeat proteins;darpin
6fpb(334);6fp9(301);9gtk(291);7b4t(284);7b4w(281);7zyu(280);7z7e(278);7z7c(278);9g8i(277);8u1b(277);9dmi(277);7z71(276);2xee(269);7z72(265);9gnb(263);8aed(263);5op3(263);5oou(262);2xeh(261);2bkg(261);7dng(261);5kng(261);7dnf(261);5knh(261);8a19(261);5oos(258);6c9k(258);8ql6(256);8ql5(256);9fe2(256);8ql9(256);9fe3(256);...
6fp7(305);6fp8(301);4hrm(285);5ma4(278);5mak(278);5ma3(278);5ma5(278);5ma6(277);5ma8(277);5ma9(277);4k5b(274);4hrl(274);5fin(273);5fio(273);5op1(267);4k5a(267);3zu7(266);2p2c(265);3noc(263);5o2s(263);5mlb(263);2bkk(262);5aq8(262);4k5c(261);3nog(260);5lel(260);5oov(259);6d65(259);1svx(259);5ooy(258);4f6r(258);4hna(258);...
6fpb(0.972299993);6fp9(0.9764999747);9gtk(0.975300014);7b4w(0.9695000052);7z7e(0.9684000015);2xeh(0.9631000161);7zyu(0.9588000178);7z7c(0.9715999961);7b4t(0.9523000121);7z71(0.962199986);2xee(0.9659000039);5kng(0.9599000216);5knh(0.9538000226);8aed(0.9635000229);1mj0(0.9575999975);9epa(0.962199986);5le8(0.9620000124);5...
6fp7(0.9559999704);6fp8(0.9620000124);5ma8(0.9519000053);5fin(0.9667999744);5aq8(0.9641000032);4k5a(0.9666000009);5ma9(0.9653999805);5ma5(0.9682999849);4k5c(0.9552000165);5mak(0.959100008);5ma4(0.9546999931);4k5b(0.9577999711);4ydy(0.9534000158);4jb8(0.9517999887);5aq7(0.9520999789)
6fpb(334)
6fp7(305)
6fp9(0.9764999747)
5ma5(0.9682999849)
1.10.10.2400;1.25.40.40;1.10.220.10
null
6fpb
2018-10-03
other
id:A;type:D;source:synthetic construct;length:166;seq_nat:GPGSDLGKKLLEAARAGQDDEVRILMANGADVNAEDWMGATPLHLAAQSGHLEIVEVLLKTGADVNAHDAFGWTPLHLAASQGHLEIVEVLLKAGADVNATDMVGRTPLHLAARRGHLEIVEVLLKHGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAAKLN;seq_unnat:GPGSDLGKKLLEAARAGQDDEVRILMANGADVNAEDWMGATPLHLAAQSGHLEIVEVLLKTGADVNAHDAFGWTPLHLAASQGHLEI...
17,364.582
I 4
66.224|66.224|77.913|90.00|90.00|90.00
X-RAY DIFFRACTION
null
M.A. Vigano;D. Bieli;J.V. Schaefer;R.P. Jakob;S. Matsuda;T. Maier;A. Pluckthun;M. Affolter
"DARPins recognizing mTFP1 as novel reagents forin vitroandin vivoprotein manipulations", Biol Open, 7
10.1242/bio.036749|30237292||2046-6390|
UK
Crystal structure of anti-mtfp1 darpin 1238_g01 in space group i4
de novo protein;protein binder;designed ankyrin repeat protein;darpin
6fpa(334);6fp9(301);9gtk(291);7b4t(284);7b4w(281);7zyu(280);7z7e(278);7z7c(278);9g8i(277);8u1b(277);9dmi(277);7z71(276);2xee(269);7z72(265);9gnb(263);8aed(263);5op3(263);5oou(262);2xeh(261);2bkg(261);7dng(261);5kng(261);7dnf(261);5knh(261);8a19(261);5oos(258);6c9k(258);8ql6(256);8ql5(256);9fe2(256);8ql9(256);9fe3(256);...
6fp7(305);6fp8(301);4hrm(285);5ma4(278);5mak(278);5ma3(278);5ma5(278);5ma6(277);5ma8(277);5ma9(277);4k5b(274);4hrl(274);5fin(273);5fio(273);5op1(267);4k5a(267);3zu7(266);2p2c(265);3noc(263);5o2s(263);5mlb(263);2bkk(262);5aq8(262);4k5c(261);3nog(260);5lel(260);5oov(259);6d65(259);1svx(259);5ooy(258);4f6r(258);4hna(258);...
6fpa(0.9740999937);6fp9(0.9781000018);9gtk(0.9836000204);2xeh(0.9679999948);7b4w(0.9728999734);7z7e(0.9812999964);5kng(0.9574000239);7z7c(0.9739999771);7zyu(0.9624999762);2xee(0.9704999924);7b4t(0.9670000076);5knh(0.9625999928);7z71(0.9725000262);1mj0(0.9689999819);4j8y(0.9578999877);4ydw(0.9613999724);5le8(0.963100016...
6fp8(0.9750999808);6fp7(0.9657999873);5fin(0.9717000127);5ma9(0.9800999761);4k5c(0.9585000277);5aq9(0.9646999836);4k5a(0.9733999968);5ma8(0.9599000216);5aq8(0.9577000141);4k5b(0.9656000137);5ma5(0.9713000059);4hrl(0.9570999742);4ydy(0.956799984);5ma6(0.9552999735);5mak(0.9599000216);6f5e(0.9514999986);5ma4(0.9580000043...
6fpa(334)
6fp7(305)
9gtk(0.9836000204)
5ma9(0.9800999761)
1.10.10.2400;1.25.40.70;1.10.220.10;1.25.10.10;1.25.40.1040;1.25.40.20
null
6g65
2018-10-17
other
id:A,B,C,D,E,F,G,H,I,J,K,L;type:U;source:unknown;length:32;seq_nat:XGEVAQAVKEVAKAVKEVAWAVKEVAQAVKGX;seq_unnat:(ACE)GEVAQAVKEVAKAVKEVAWAVKEVAQAVKG(NH2)
3,122.655
C 1 2 1
65.561|96.793|56.400|90.000|124.020|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel six-helix coiled coil cc-type2-vv
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
4pna(1);5ez8(1);6g66(1);6g67(1);6g6e(1);7nfj(1);7nfl(1);7nfm(1);9f5a(1);6g68(0.9987000227);6g69(0.9987000227);6xy1(0.9987000227);7baw(0.9987000227);7bim(0.9973999858);7nff(1);7nfi(0.9973999858);6g6a(0.9898999929);6g6c(0.9977999926);6g6f(0.9901000261);6g6g(0.9977999926);8b16(0.9987000227);7nfk(0.9575999975);4pn9(0.97820...
null
6g65(0)
null
5ez8(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110...
null
6g66
2018-10-17
other
id:A,B,C,D,E,F,G;type:U;source:unknown;length:32;seq_nat:XGEVAQAIKEVAKAIKEVAWAIKEVAQAIKGX;seq_unnat:(ACE)GEVAQAIKEVAKAIKEVAWAIKEVAQAIKG(NH2)
3,178.763
P 2 21 21
38.240|48.350|130.009|90.000|90.000|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel seven-helix coiled coil cc-type2-iv
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
6g69(1);6g68(1);9f5a(1);6g65(1);6g67(1);7baw(1);6g6c(1);6g6g(1);7nff(0.9986000061);6g6a(0.992200017);6g6b(0.994599998);6g6d(1);7bat(0.992299974);7nfl(1);4pna(1);5ez8(1);6g6e(1);7bim(1);7nfh(0.9714999795);7nfi(1);7nfj(1);7nfm(1);7nfk(0.9575999975);6xy1(1);7nfo(0.9796000123);8b16(1);6g6f(0.9990000129);8b15(0.9549999833);...
null
6g66(0)
null
6g69(1)
null
1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.770;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;6.10.250.2370;1.20.5.3960;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1.20.5.250;1.20...
null
6g67
2018-10-17
other
id:A,B;type:U;source:unknown;length:32;seq_nat:XGEIAQAIKEIAKAIKEIAWAIKEIAQAIKGX;seq_unnat:(ACE)GEIAQAIKEIAKAIKEIAWAIKEIAQAIKG(NH2)
3,234.871
I 4 2 2
48.110|48.110|126.969|90.000|90.000|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel eight-helix coiled coil cc-type2-ii
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
4pna(1);5ez8(1);6g65(1);6g66(1);6g6e(1);7bim(1);7nff(0.9986000061);7nfi(1);7nfj(1);7nfl(1);7nfm(1);9f5a(1);6g69(1);6xy1(1);7baw(1);6g68(1);6g6c(1);6g6f(0.9930999875);6g6g(1);8b16(1);7nfk(0.9575999975);4pn9(0.9857000113);6eiz(0.9775999784);6g6a(0.9875000119);6g6b(0.9934999943);6g6d(0.9908999801);6yb2(0.9944000244);7bat(...
null
6g67(0)
null
4pna(1)
null
1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;6.10.250.2370;1.20.5.3960;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1.20.5.250;1...
null
6g68
2018-10-17
other
id:A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R;type:U;source:unknown;length:32;seq_nat:XGELAQSIKELAKSIKELAWSIKELAQSIKGX;seq_unnat:(ACE)GELAQSIKELAKSIKELAWSIKELAQSIKG(NH2)
3,298.871
P 2 21 21
58.361|90.030|112.470|90.000|90.000|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel six-helix coiled coil cc-type2-il-sg
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
6g69(1);6g6d(1);7bat(0.9887999892);7baw(1);7bau(0.97299999);6g66(1);4pn9(0.997600019);6eiz(0.9965000153);6g6a(0.9902999997);8b16(1);6g65(0.9987000227);6g67(1);6g6b(1);6g6c(1);7bo8(1);7bo9(1);9f5a(0.9988999963);8b15(0.9563999772);8a09(0.9575999975);7boa(1);3r4a(0.9983999729);3r4h(0.9879999757);6g6f(1);6g6g(1);7nfh(0.976...
null
6g68(0)
null
8b16(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;6.10.250.1210;1.20.5.470;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850...
null
6g69
2018-10-17
other
id:A,B,C,D,E,F,G,H,I,J,K,L,M,N;type:U;source:unknown;length:32;seq_nat:XGELAQSIKELAKSIKEEAWSIKELAQSIKGX;seq_unnat:(ACE)GELAQSIKELAKSIKEEAWSIKELAQSIKG(NH2)
3,314.827
H 3
66.770|66.770|243.197|90.000|90.000|120.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel seven-helix coiled coil cc-type2-il-sg-l17e
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
6g68(1);6g6d(1);6g6c(1);7baw(1);7bat(0.9897999763);8b16(1);6g6b(0.9986000061);7bau(0.989199996);6g66(1);4pn9(0.9986000061);6eiz(0.9897999763);7bo8(1);7bo9(1);6g65(0.9987000227);6g67(1);6g6a(0.9937999845);9f5a(0.9990000129);8a09(0.9772999883);6g6f(1);7bim(1);8b15(0.9714000225);7bav(0.9800000191);6g6g(0.9800999761);7nfh(...
null
6g69(0)
null
6g68(1)
null
6.10.250.770;6.10.250.1960;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;6.10.250.1560;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;6.10.250.270;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.2720;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250...
null
6g6a
2018-10-17
other
id:A,B,C;type:U;source:unknown;length:32;seq_nat:XGELAQALKELAKALKELAWALKELAQALKGX;seq_unnat:(ACE)GELAQALKELAKALKELAWALKELAQALKG(NH2)
3,234.871
P 41 3 2
103.529|103.529|103.529|90.000|90.000|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel six-helix coiled coil cc-type2-ll
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
6g6d(0.9983999729);6xy1(0.9955000281);4pn9(0.9961000085);6eiz(0.9940000176);6g68(0.9929999709);6g69(0.993900001);6g6b(0.9918000102);6g6c(0.992200017);6g6f(0.996999979);6g6g(0.996900022);6yb2(0.9983999729);7baw(0.9983999729);7nfg(0.9951999784);8b16(0.996900022);4pna(0.9990000129);7bat(0.9898999929);7nff(0.9951000214);7n...
null
6g6a(0)
null
4pna(0.9990000129)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;1.20.5.470;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850...
null
6g6b
2018-10-17
other
id:A,B,C;type:U;source:unknown;length:32;seq_nat:XGELAQALKELAKALKEQAWALKELAQALKGX;seq_unnat:(ACE)GELAQALKELAKALKEQAWALKELAQALKG(NH2)
3,249.842
P 41 3 2
104.790|104.790|104.790|90.000|90.000|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel six-helix coiled coil cc-type2-ll-l17q
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
8b16(0.9986000061);6g6f(0.996999979);7baw(0.9941999912);8a09(0.9923999906);4pn9(0.996999979);4pna(0.9973000288);5ez8(0.9962000251);6eiz(0.9984999895);6g6a(0.9940000176);7nfk(0.9936000109);8b15(0.9882000089);7bat(0.9933000207);7bim(0.9930999875);7nfj(0.9957000017);5ezc(0.9972000122);7nfo(0.9900000095);5eze(0.9909999967)...
null
6g6b(0)
null
6g68(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;6.10.250.270;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2720;6.10.250.2370;1.20.5.470;6.10.250.1210;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380...
null
6g6c
2018-10-17
other
id:A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X;type:U;source:unknown;length:32;seq_nat:XGELAQALKELAKALKEEAWALKELAQALKGX;seq_unnat:(ACE)GELAQALKELAKALKEEAWALKELAQALKG(NH2)
3,250.827
P 1 21 1
45.319|117.940|59.240|90.000|101.240|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel six-helix coiled coil cc-type2-ll-l17e
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
6g69(1);6g6b(0.994599998);8b16(1);6g6f(1);4pn9(1);6eiz(0.9955000281);6xy1(1);7nfo(0.9811999798);4pna(1);6g6a(0.9921000004);6g6d(0.9983999729);7bat(0.9983999729);7baw(1);7nff(0.9986000061);7nfj(1);6yb0(0.9769999981);5ez8(1);6g6g(1);7bim(1);7nfi(1);7nfl(1);7nfm(1);5eza(1);5ezc(1);6g65(0.9977999926);6g66(1);6g68(1);7nfh(0...
null
6g6c(0)
null
6g69(1)
null
null
null
6g6d
2018-10-17
other
id:A,B,C;type:U;source:unknown;length:32;seq_nat:XGELAQSLKELAKSLKELAWSLKELAQSLKGX;seq_unnat:(ACE)GELAQSLKELAKSLKELAWSLKELAQSLKG(NH2)
3,298.871
P 41 3 2
104.160|104.160|104.160|90.000|90.000|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel six-helix coiled coil cc-type2-ll-sg
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
4pn9(0.9966999888);6eiz(0.9907000065);6g68(0.9987000227);6g69(0.9987000227);8b16(0.9951999784);8a09(0.9728000164);8b15(0.9682000279);7bat(0.992200017);7baw(1);7bas(0.9937999845);7bav(0.9955000281);7bau(0.9851999879);7bim(0.9936000109);7a1t(0.9983000159);6g6a(0.9983999729);6g6b(0.9879000187);6g6c(0.9983999729);6g6f(0.99...
null
6g6d(0)
null
7baw(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;1.20.5.470;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850...
null
6g6e
2018-10-17
other
id:A,B,C,D,E,F,G;type:U;source:unknown;length:32;seq_nat:XGEIAQAXKEIAKAXKEIAWAXKEIAQAXKGX;seq_unnat:(ACE)GEIAQA(EO2)KEIAKA(EO2)KEIAWA(EO2)KEIAQA(EO2)KG(NH2)
3,226.807
P 2 21 21
38.201|47.950|129.339|90.000|90.000|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel seven-helix coiled coil cc-type2-deli
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
7nfm(1);5ez8(1);6g6g(1);7nfi(1);7nfj(1);6yaz(0.9599999785);4pna(1);6yb2(1);7bim(1);6xy1(1);5ez9(1);7nfg(1);4pn9(0.997699976);6eiz(0.9957000017);7nff(1);5eza(1);7nfh(0.9728000164);7nfl(1);7nfn(1);9f5a(1);6zt1(1);7a1t(1);7nfo(0.9779999852);8b16(1);6g65(1);6g67(1);7bas(1);7bav(1);7baw(1);7qwa(1);7qwd(1);7qwe(1);5ezc(1);6g...
null
6g6e(0)
null
7nfm(1)
null
1.20.5.420;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.270;6.10.250.2060;6.10.250.1090;6.10.250.1210;6.10.250.1020;1.20.5.1610;6.10.250.490;1.20.5.110;1.20.5.250;1.20.5.460;1.20.5.740;6.10.250.450;1.20.5.170;6.10.250.860;1.20.5.100;1.20.5.70;1.20.5.510;1.20.5.220;1.20.5.1190;1.20.5.590;1.20.5.140;6.10.250.2330
null
6g6f
2018-10-17
other
id:A,B,C,D,E,F,G,H;type:U;source:unknown;length:32;seq_nat:XGEFAQALKEFAKALKEFAWALKEFAQALKGX;seq_unnat:(ACE)GEFAQALKEFAKALKEFAWALKEFAQALKG(NH2)
3,370.935
P 1 21 1
42.000|58.990|47.050|90.000|109.130|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel eight-helix coiled coil cc-type2-lf
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
7bo8(1);7bo9(1);6eiz(1);4pn9(1);6xy1(1);8b16(1);7nfl(1);8a09(0.9983999729);4pna(1);7bim(1);7nff(1);7nfg(1);7nfo(0.9957000017);8b15(0.9951000214);7nfk(0.9990000129);5ez8(1);6g6c(1);7bav(1);7nfm(1);6eik(0.9990000129);6g6b(0.996999979);6yb2(1);7a1t(1);7bas(1);7qwa(1);7qwd(1);7qwe(1);6zt1(1);7nfj(1);7nfn(1);7qwb(0.99659997...
null
6g6f(0)
null
4pn9(1)
null
null
null
6g6g
2018-10-17
other
id:A,B,C,D,E,F,G,H,I,J,K,L;type:U;source:unknown;length:32;seq_nat:XGEIAQAFKEIAKAFKEIAWAFKEIAQAFKGX;seq_unnat:(ACE)GEIAQAFKEIAKAFKEIAWAFKEIAQAFKG(NH2)
3,370.935
P 1 21 1
30.660|85.000|59.608|90.000|92.490|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of a parallel six-helix coiled coil cc-type2-fi
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
null
null
6g6e(1);7nfj(1);6yb2(1);7nfi(1);6yaz(0.9611999989);4pn9(1);6eiz(1);6xy1(1);7nfg(1);7nfm(1);4pna(1);5ez8(1);7bim(1);7nfh(0.9778000116);8a09(0.9714000225);8b16(1);9f5a(0.997699976);5ez9(1);7nff(1);7nfo(0.9792000055);5eza(1);7nfl(1);8b15(0.9664000273);7a1t(1);7bas(1);7bav(1);7qwd(1);6zt1(1);7nfn(1);7qwa(1);7qwe(1);7nfk(0....
null
6g6g(0)
null
6g6e(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;1.20.5.470;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850...
null
6g6h
2018-10-17
other
id:A,B,C,D,E;type:U;source:unknown;length:35;seq_nat:XTQEYLLKELMKLLKEQIKLLKEQIKMLKELEKQX;seq_unnat:(ACE)TQEYLLKELMKLLKEQIKLLKEQIKMLKELEKQ(NH2)
4,134.103
P 21 21 21
34.290|65.320|83.370|90.000|90.000|90.000
X-RAY DIFFRACTION
Solid-phase peptide synthesis using the fmoc-based strategy
G.G. Rhys;C.W. Wood;E.J.M. Lang;A.J. Mulholland;R.L. Brady;A.R. Thomson;D.N. Woolfson
"Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nat Commun, 9, 4132-4132
10.1038/s41467-018-06391-y|30297707||2041-1723|
UK
Crystal structure of an antiparallel five-helix coiled coil 5h2l_2.1-i9l
de novo protein;synthetic construct;alpha-helical bundle;de novo;coiled coil
4uot(55)
null
4uot(1);6dm9(0.9718000293)
null
4uot(55)
null
4uot(1)
null
6.10.250.770;1.20.5.420;6.10.250.2070;1.20.5.430;1.20.5.1450;1.20.5.750;1.20.5.700;6.10.250.2150;6.10.250.200;6.10.250.2720;1.10.287.210;6.10.250.2060;1.20.5.470;6.10.250.1090;6.10.250.270;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.850;6.10.250.380;1.20.5.110;1.20.5.250;1.20.5.580;1.20.5.460;1.20.890....
null
6g6m
2018-11-28
other
id:A;type:D;source:synthetic construct;length:329;seq_nat:GSHMGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQ...
35,024.23
P 42 21 2
90.401|90.401|91.854|90.00|90.00|90.00
X-RAY DIFFRACTION
null
H. Noguchi;C. Addy;D. Simoncini;S. Wouters;B. Mylemans;L. Van Meervelt;T. Schiex;K.Y.J. Zhang;J.R.H. Tame;A.R.D. Voet
"Computational design of symmetrical eight-bladed beta-propeller proteins", IUCrJ, 6, 46-55
10.1107/S205225251801480X|30713702||2052-2525|
UK
Crystal structure of the computationally designed tako8 protein in p42212
wd40 proteins;de novo protein;artificial protein
6g6n(649);6y7n(649);6y7p(649);6y7o(646);6g6o(440);6g6p(440);7bie(243);6g6q(227);7bid(227);7big(223);7bif(218);6r5z(96)
5v4b(323);2ovp(323);2ovq(323);2ovr(323);2ymu(255);5mzh(246);1p22(243);5nnz(242);3emh(205);9kfm(204);9kfn(204);9kfo(204);9l0t(204);9l0v(204);4a7j(204);2h9p(204);2h9l(204);5m23(204);5m25(204);6byn(203);2g99(203);5vfc(203);2g9a(203);2h6k(203);3ur4(203);4es0(203);4esg(203);4qqe(203);3smr(203);4erq(203);5eal(203);2h6n(203);...
6y7n(0.9912999868);6y7p(0.9696999788);6y7o(0.9620000124);6g6n(0.9800999761)
null
6g6n(649)
5v4b(323)
6y7n(0.9912999868)
5mzh(0.868900001)
2.40.10.500;2.40.128.660;2.20.25.650;2.40.128.630;2.40.128.650
null
6g6n
2018-11-28
other
id:A,B,C;type:D;source:synthetic construct;length:329;seq_nat:GSHMGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAVTSLQFNDNIVVSGSDDSTVKVWDIKTGQSLRTLQGHQSAV...
35,024.23
C 1 2 1
93.548|132.297|81.015|90.00|125.26|90.00
X-RAY DIFFRACTION
null
H. Noguchi;C. Addy;D. Simoncini;S. Wouters;B. Mylemans;L. Van Meervelt;T. Schiex;K.Y.J. Zhang;J.R.H. Tame;A.R.D. Voet
"Computational design of symmetrical eight-bladed beta-propeller proteins", IUCrJ, 6, 46-55
10.1107/S205225251801480X|30713702||2052-2525|
UK
Crystal structure of the computationally designed tako8 protein in c2
wd40 proteins;de novo protein;artificial protein
6g6m(649);6y7n(649);6y7p(649);6y7o(646);6g6o(440);6g6p(440);7bie(243);6g6q(227);7bid(227);7big(223);7bif(218);6r5z(96)
5v4b(323);2ovp(323);2ovq(323);2ovr(323);2ymu(255);5mzh(246);1p22(243);5nnz(242);3emh(205);9kfm(204);9kfn(204);9kfo(204);9l0t(204);9l0v(204);4a7j(204);2h9p(204);2h9l(204);5m23(204);5m25(204);6byn(203);2g99(203);5vfc(203);2g9a(203);2h6k(203);3ur4(203);4es0(203);4esg(203);4qqe(203);3smr(203);4erq(203);5eal(203);2h6n(203);...
6g6m(0.983099997);6y7p(0.9775000215);6y7n(0.9839000106);6y7o(0.9649000168)
null
6g6m(649)
5v4b(323)
6y7n(0.9839000106)
5mzh(0.861100018)
2.130.10.150;2.130.10.120;2.130.10.80;2.120.10.80;2.130.10.130;2.120.10.60;2.130.10.110;2.120.10.70;2.130.10.10;2.130.10.30;2.120.10.10;2.120.10.30
null
6g6o
2018-11-28
other
id:A,B,C;type:D;source:synthetic construct;length:328;seq_nat:GSHMGQELVSLEGHQSAITALAFSKNIVVSGAADGTIKVWDILTGQLLRDHDGHQSEVTALQFKDNIVVSGAKDGTVKVWYIGTGQELVSLEGHQSAITALAFSKNIVVSGAADGTIKVWDILTGQLLRDHDGHQSEVTALQFKDNIVVSGAKDGTVKVWYIGTGQELVSLEGHQSAITALAFSKNIVVSGAADGTIKVWDILTGQLLRDHDGHQSEVTALQFKDNIVVSGAKDGTVKVWYIGTGQELVSLEGHQSAI...
34,421.574
P 63
218.609|218.609|53.569|90.00|90.00|120.00
X-RAY DIFFRACTION
null
H. Noguchi;C. Addy;D. Simoncini;S. Wouters;B. Mylemans;L. Van Meervelt;T. Schiex;K.Y.J. Zhang;J.R.H. Tame;A.R.D. Voet
"Computational design of symmetrical eight-bladed beta-propeller proteins", IUCrJ, 6, 46-55
10.1107/S205225251801480X|30713702||2052-2525|
UK
Crystal structure of the computationally designed ika8 protein: crystal packing no.1 in p63
wd40 proteins;de novo protein;artificial protein
6g6p(655);6y7o(439);6g6n(437);6g6m(437);6y7n(437);6y7p(437);6g6q(333);7bie(173);7big(162);7bid(161);7bif(156);6r5z(69)
5v4b(249);2ovp(249);2ovq(249);2ovr(249);5nnz(196);5mzh(192);1p22(188);2ymu(180);5yzv(169);4cy3(161);4cy5(161);8rl2(161);9kfm(157);9kfn(157);9kfo(157);9l0t(157);9l0v(157);6byn(156);2g99(156);5vfc(156);2g9a(156);2h6k(156);3ur4(156);4es0(156);4esg(156);4qqe(156);3smr(156);4erq(156);5eal(156);2h6n(156);4ql1(156);5eam(156);...
6g6p(0.9697999954)
null
6g6p(655)
5v4b(249)
6g6p(0.9697999954)
5mzh(0.7620000243)
2.130.10.150;2.40.128.190;2.40.10.360;2.120.10.80;2.120.10.60;2.130.10.30;2.120.10.70;2.40.128.630;2.130.10.10;2.60.40.790;2.120.10.10;2.120.10.30
null
6g6p
2018-11-28
other
id:A;type:D;source:synthetic construct;length:328;seq_nat:GSHMGQELVSLEGHQSAITALAFSKNIVVSGAADGTIKVWDILTGQLLRDHDGHQSEVTALQFKDNIVVSGAKDGTVKVWYIGTGQELVSLEGHQSAITALAFSKNIVVSGAADGTIKVWDILTGQLLRDHDGHQSEVTALQFKDNIVVSGAKDGTVKVWYIGTGQELVSLEGHQSAITALAFSKNIVVSGAADGTIKVWDILTGQLLRDHDGHQSEVTALQFKDNIVVSGAKDGTVKVWYIGTGQELVSLEGHQSAITALA...
34,421.574
P 63
127.374|127.374|53.869|90.00|90.00|120.00
X-RAY DIFFRACTION
null
H. Noguchi;C. Addy;D. Simoncini;S. Wouters;B. Mylemans;L. Van Meervelt;T. Schiex;K.Y.J. Zhang;J.R.H. Tame;A.R.D. Voet
"Computational design of symmetrical eight-bladed beta-propeller proteins", IUCrJ, 6, 46-55
10.1107/S205225251801480X|30713702||2052-2525|
UK
Crystal structure of the computationally designed ika8 protein: crystal packing no.2 in p63
wd40 proteins;de novo protein;artificial protein
6g6o(655);6y7o(439);6g6n(437);6g6m(437);6y7n(437);6y7p(437);6g6q(333);7bie(173);7big(162);7bid(161);7bif(156);6r5z(69)
5v4b(249);2ovp(249);2ovq(249);2ovr(249);5nnz(196);5mzh(192);1p22(188);2ymu(180);5yzv(169);4cy3(161);4cy5(161);8rl2(161);9kfm(157);9kfn(157);9kfo(157);9l0t(157);9l0v(157);6byn(156);2g99(156);5vfc(156);2g9a(156);2h6k(156);3ur4(156);4es0(156);4esg(156);4qqe(156);3smr(156);4erq(156);5eal(156);2h6n(156);4ql1(156);5eam(156);...
6g6o(0.970600009)
null
6g6o(655)
5v4b(249)
6g6o(0.970600009)
5mzh(0.7659000158)
2.40.10.500;2.120.10.80;2.40.10.360;2.120.10.90;2.120.10.60;2.130.10.10;2.40.128.630;2.120.10.30
null
6g6q
2018-11-28
other
id:A,B,C,D,E,F,G,H,I,J,K,L;type:D;source:synthetic construct;length:166;seq_nat:GSHMGQELVSLEGHQSAITALAFSKNIVVSGAADGTIKVWDILTGQLLRDHDGHQSEVTALQFKDNIVVSGAKDGTVKVWYIGTGQELVSLEGHQSAITALAFSKNIVVSGAADGTIKVWDILTGQLLRDHDGHQSEVTALQFKDNIVVSGAKDGTVKVWYIGT;seq_unnat:GSHMGQELVSLEGHQSAITALAFSKNIVVSGAADGTIKVWDILTGQLLRDHDGHQSEVTALQFKD...
17,426.537
P 21 21 21
53.520|219.190|264.910|90.00|90.00|90.00
X-RAY DIFFRACTION
null
H. Noguchi;C. Addy;D. Simoncini;S. Wouters;B. Mylemans;L. Van Meervelt;T. Schiex;K.Y.J. Zhang;J.R.H. Tame;A.R.D. Voet
"Computational design of symmetrical eight-bladed beta-propeller proteins", IUCrJ, 6, 46-55
10.1107/S205225251801480X|30713702||2052-2525|
UK
Crystal structure of the computationally designed ika4 protein
wd40 proteins;de novo protein;artificial protein
6g6o(333);6g6p(333);6y7o(226);6g6n(226);6g6m(226);6y7n(226);6y7p(226);7big(96);7bif(95);7bid(95);7bie(95);6r5z(69)
5v4b(138);2ovp(138);2ovq(138);2ovr(138);5mzh(129);1p22(118);5nnz(111);5yzv(106);4cy3(106);4cy5(106);6byn(100);2g99(100);5vfc(100);2g9a(100);2h6k(100);3ur4(100);4es0(100);4esg(100);4qqe(100);3smr(100);4erq(100);5eal(100);2h6n(100);4ql1(100);5eam(100);5eap(100);2h6q(100);5ear(100);4ia9(100);4ewr(100);4ery(100);4o45(100);...
6g6o(0.9866999984)
null
6g6o(333)
5v4b(138)
6g6o(0.9866999984)
2ovr(0.8399999738)
2.40.10.500;2.60.220.10;2.40.128.660;2.20.25.650;2.40.128.630;2.40.128.650
null
6h5h
2018-12-12
other
id:A;type:D;source:synthetic construct;length:122;seq_nat:MKHHHHHHPMSDYDIPTTENLYFQGAMGGQETLNGALVNMLKEEGNKALSVGNIDDALQYYAAAITLDKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFL;seq_unnat:MKHHHHHHPMSDYDIPTTENLYFQGAMGGQETLNGALVNMLKEEGNKALSVGNIDDALQYYAAAITLDKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFL
13,443.259
null
|||||
SOLUTION NMR
null
M. ElGamacy;M. Coles;A. Lupas
"Asymmetric protein design from conserved supersecondary structures", J. Struct. Biol., 204, 380-387
10.1016/j.jsb.2018.10.010|30558718|0803|1095-8657|JSBIEM
US
A computationally designed drp lyase domain reconstructed from two heterologous fragments
protein design;drp lyase domain;unknown function
null
3v7j(128);3v7k(126);3v7l(126);4nlk(123);4phe(123);4nln(123);4pgq(123);5hhi(123);4tur(123);4nlz(123);4pgy(123);4pha(123);4o5c(123);4o5e(123);4mf8(123);4nm1(123);4nm2(123);4tup(123);4phd(123);1mq2(123);2pxi(123);3c2l(123);5eoz(123);5j0t(123);5ugo(123);6bte(123);1zqh(123);3isd(123);3jpn(123);3v72(123);4doa(123);4klh(123);...
null
null
6h5h(0)
3v7j(128)
9y59(0.6687999964)
6bte(0.9110999703)
1.10.150.80;1.20.1440.140;1.20.120.710;1.10.150.50;1.10.150.130;1.10.150.110;1.10.287.10;1.10.150.20;1.20.1440.50
null
6h7i
2019-08-14
other
id:A;type:U;source:unknown;length:13;seq_nat:SWTWENGKWTWKX;seq_unnat:SWTWENGKWTWK(NH2)
1,608.776
null
|||||
SOLUTION NMR
null
S.H. Prior;I.J. Scowen
To be published
||||
null
Trpzip2 structure in presence of exogenous haloprotectant molecule
de novo protein;halophilic;stabilisation
null
null
null
null
6h7i(0)
2mnu(36)
1le3(0.8927000165)
6h7q(0.9237999916)
null
null
6hqe
2019-06-26
other
id:A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f,g,h,i,j,k,l,m,n,o,p,q,r,s,t,u,v,w,x,y,z;type:U;source:unknown;length:23;seq_nat:PEALERLAADPDREVRAAVARRL;seq_unnat:PEALERLAADPDREVRAAVARRL
2,579.933
null
|||||
ELECTRON MICROSCOPY
null
S.A. Hughes;F. Wang;S. Wang;M.A.B. Kreutzberger;T. Osinski;A. Orlova;J.S. Wall;X. Zuo;E.H. Egelman;V.P. Conticello
"Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs", Proc.Natl.Acad.Sci.USA, 116, 14456-14464
10.1073/pnas.1903910116|31262809|0040|1091-6490|PNASA6
US
Cryo-em of self-assembly peptide filament lrv_m3delta1
filament;cryo-em;self-assembly peptide filament;protein fibril
null
null
null
null
null
null
null
null
null
null
6hsh
2018-10-31
other
id:A,B,C,D;type:N;source:Schistosoma mansoni;length:452;seq_nat:HMSVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSTPPETSPNRQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNMVDNDKLPIFLNGAGRGRFSAFNLPLEEGIND...
50,583.027
P 1
70.750|70.800|97.820|78.03|75.67|85.74
X-RAY DIFFRACTION
null
M. Marek;T.B. Shaik;T. Heimburg;A. Chakrabarti;J. Lancelot;E. Ramos-Morales;C. Da Veiga;D. Kalinin;J. Melesina;D. Robaa;K. Schmidtkunz;T. Suzuki;R. Holl;E. Ennifar;R.J. Pierce;M. Jung;W. Sippl;C. Romier
"Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants", J. Med. Chem., 61, 10000-10016
10.1021/acs.jmedchem.8b01087|30347148|0151|1520-4804|JMCMAR
US
Crystal structure of schistosoma mansoni hdac8 complexed with quisinostat
pathogen;epigenetics;hdac8;hydrolase;histone deacetylase;selective inhibitor
null
null
null
null
null
null
null
null
null
null
6i1j
2019-09-04
other
id:A;type:U;source:unknown;length:32;seq_nat:GEIAAIKQEIAAHKKEHAAIKWEIAAIKQGYG;seq_unnat:GEIAAIKQEIAAHKKEHAAIKWEIAAIKQGYG
3,481.029
P 63 2 2
30.517|30.517|106.035|90.00|90.00|120.00
X-RAY DIFFRACTION
null
A.L. Boyle;M. Rabe;N.S.A. Crone;G.G. Rhys;N. Soler;P. Voskamp;N.S. Pannu;A. Kros
"Selective coordination of three transition metal ions within a coiled-coil peptide scaffold", Chem Sci, 10, 7456-7465
10.1039/c9sc01165j|31489168||2041-6520|
UK
Selective formation of trinuclear transition metal centers in a trimeric helical peptide
de novo protein;copper-binding peptide;trimeric coiled coil
null
null
3r4a(0.9926000237);8b45(0.9828000069);3r4h(0.9862999916);4dzl(0.9926999807);6q5p(0.9951999784);6q5n(0.9897000194);3r46(0.9933000207);4dzm(0.9980999827);4dzn(0.997600019);6q5j(0.9919000268);4h8g(0.9937000275);4h8m(0.9912999868);4h7r(0.9947000146);3r48(0.9923999906);3r3k(0.9919999838);7qdk(0.996999979);8bfe(0.9876999855)...
4kvt(0.9923999906)
6i1j(0)
null
4dzm(0.9980999827)
4kvt(0.9923999906)
1.20.5.110
null
6i37
2019-11-20
other
id:A;type:D;source:synthetic construct;length:258;seq_nat:GSHMFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVL;seq_un...
25,760.391
P 21 21 21
48.256|55.977|69.352|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B. Mylemans;H. Noguchi;E. Deridder;E. Lescrinier;J.R.H. Tame;A.R.D. Voet
"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein", Protein Sci.
10.1002/pro.3961|33006397|0795|1469-896X|PRCIEI
US
Crystal structure of nv1pizza6-ayw, a circularly permuted designer protein
circularly permuted designer protein;beta-propeller;pizza;artificial protein;de novo protein
6i38(498);6f0q(488);6i3b(487);6f0s(479);7zq2(475);7zqg(475);7zcj(474);6i39(471);6reh(469);6qsf(469);6rei(469);7ov7(469);6qsg(469);6qsh(469);6reg(469);6qsd(469);7zpz(469);6qse(469);7zpw(468);6i3a(466);6rej(464);6rek(464);6f0t(464);6rem(464);6rel(464);7zph(460);6reo(439);6rlh(439);6rli(439);6ren(439);4zcn(170);5f53(170);...
1rwi(319);1rwl(319);2z2p(91);6fpt(90);6fql(90);6fq3(90);2z2n(89);2z2o(89);2qc5(87);6d69(68);3v64(57);3v65(57);5gje(53);6h15(53);6h16(53);5fww(53);3s8v(53);3s8z(53);4a0p(53);3s2k(53);6fb3(53);9g2h(53);6cmx(52);9g42(52);9g41(52);9g2f(52)
null
null
6i38(498)
1rwi(319)
6reo(0.940500021)
1rwl(0.8463000059)
2.40.10.500;2.40.128.190;2.40.10.360;2.20.25.650;2.40.128.630
null
6i38
2019-11-20
other
id:A;type:D;source:synthetic construct;length:258;seq_nat:GSHMLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFT;seq_un...
25,800.455
P 21 21 21
49.295|57.397|69.827|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B. Mylemans;H. Noguchi;E. Deridder;E. Lescrinier;J.R.H. Tame;A.R.D. Voet
"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein", Protein Sci.
10.1002/pro.3961|33006397|0795|1469-896X|PRCIEI
US
Crystal structure of nv2pizza6-ayw, a circularly permuted designer protein
circularly permuted designer protein;beta-propeller;pizza;artificial protein;de novo protein
6i37(497);6i3b(481);6f0q(481);6i39(479);6f0s(471);7zq2(468);7zqg(468);7zcj(467);6reh(462);6qsf(462);6rei(462);7ov7(462);6qsg(462);6qsh(462);6reg(462);6qsd(462);7zpz(462);6qse(462);7zpw(461);6i3a(460);6f0t(459);6rej(456);6rek(456);6rem(456);6rel(456);7zph(452);6reo(432);6rlh(432);6rli(432);6ren(432);4zcn(162);5f53(162);...
1rwi(316);1rwl(316);2z2p(91);6fpt(91);6fql(91);6fq3(91);2z2n(89);2z2o(89);2qc5(87);6d69(68);3v64(57);3v65(57);5gje(53);6h15(53);6h16(53);5fww(53);3s8v(53);3s8z(53);4a0p(53);3s2k(53);6fb3(53);9g2h(53);6cmx(52);9g42(52);9g41(52);9g2f(52)
null
null
6i37(497)
1rwi(316)
7zpw(0.945200026)
1rwl(0.8500999808)
2.40.10.500;2.20.25.400;2.40.128.190;2.20.25.650;2.40.128.630;2.20.25.10
null
6i39
2019-11-20
other
id:A;type:D;source:synthetic construct;length:258;seq_nat:GSHMGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDS;seq_un...
25,786.428
P 43 21 2
69.953|69.953|84.782|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B. Mylemans;H. Noguchi;E. Deridder;E. Lescrinier;J.R.H. Tame;A.R.D. Voet
"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein", Protein Sci.
10.1002/pro.3961|33006397|0795|1469-896X|PRCIEI
US
Crystal structure of v31pizza6-ayw, a circularly permuted designer protein
circularly permuted designer protein;beta-propeller;pizza;artificial protein;de novo protein
6i3a(482);6i38(479);6i37(471);6i3b(461);6f0q(460);6f0s(454);7zq2(448);7zqg(448);7zcj(446);6reh(445);6qsf(445);6rei(445);7ov7(445);6qsg(445);6qsh(445);6reg(445);6qsd(445);6qse(445);7zpz(442);7zpw(441);6rej(439);6rek(439);6f0t(439);6rem(439);6rel(439);7zph(431);6reo(414);6rlh(414);6rli(414);6ren(414);4zcn(162);5f53(162);...
1rwi(307);1rwl(307);2z2p(85);2qc5(85);2z2n(83);2z2o(83);6d69(64);3v64(57);3v65(57)
null
null
6i3a(482)
1rwi(307)
7zpw(0.9113000035)
1rwl(0.8303999901)
2.120.10.80;2.120.10.60;2.115.10.10;2.130.10.10;2.110.10.10;2.40.128.630;2.20.25.10;2.120.10.30
null
6i3a
2019-11-20
other
id:A;type:D;source:synthetic construct;length:258;seq_nat:GSHMNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDH;seq_un...
25,800.457
P 21 21 21
49.196|56.892|69.952|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B. Mylemans;H. Noguchi;E. Deridder;E. Lescrinier;J.R.H. Tame;A.R.D. Voet
"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein", Protein Sci.
10.1002/pro.3961|33006397|0795|1469-896X|PRCIEI
US
Crystal structure of v22pizza6-ayw, a circularly permuted designer protein
circularly permuted designer protein;beta-propeller;pizza;artificial protein;de novo protein
6i39(482);6i3b(481);6f0q(481);6f0s(472);7zq2(469);7zqg(469);7zcj(467);6i37(466);6reh(463);6qsf(463);6rei(463);7ov7(463);6qsg(463);6qsh(463);6reg(463);6qsd(463);7zpz(463);6qse(463);7zpw(462);6i38(460);6f0t(458);6rej(457);6rek(457);6rem(457);6rel(457);7zph(453);6reo(432);6rlh(432);6rli(432);6ren(432);4zcn(162);5f53(162);...
1rwi(314);1rwl(314);2z2p(84);2z2n(82);2z2o(82);6fpt(80);6fql(80);6fq3(80);6d69(64);3v64(57);3v65(57);5gje(53);6h15(53);6h16(53);5fww(53);3s8v(53);3s8z(53);4a0p(53);3s2k(53)
null
null
6i39(482)
1rwi(314)
6i38(0.9301999807)
1rwl(0.8154000044)
2.40.10.500;2.40.128.190;2.40.10.360;2.110.10.10;2.20.25.650;2.40.128.630
null
6i3b
2019-11-20
other
id:A,B;type:D;source:synthetic construct;length:255;seq_nat:SNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVWVTDHGNNRVVKLAAG;seq_unn...
25,444.033
P 1 21 1
47.051|70.442|58.144|90.00|100.51|90.00
X-RAY DIFFRACTION
null
B. Mylemans;H. Noguchi;E. Deridder;E. Lescrinier;J.R.H. Tame;A.R.D. Voet
"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein", Protein Sci.
10.1002/pro.3961|33006397|0795|1469-896X|PRCIEI
US
Crystal structure of cpizza6-ayw, a circularly permuted designer protein
circularly permuted designer protein;beta-propeller;pizza;artificial protein;de novo protein
6f0q(501);6f0s(492);7zq2(489);7zqg(489);6i37(487);7zcj(487);6reh(483);6qsf(483);6rei(483);7ov7(483);6qsg(483);6qsh(483);6reg(483);6qsd(483);7zpz(483);6qse(483);6i38(482);6i3a(482);7zpw(482);6rej(477);6rek(477);6f0t(477);6rem(477);6rel(477);7zph(473);6i39(462);6reo(452);6rlh(452);6rli(452);6ren(452);4zcn(162);5f53(162);...
1rwi(329);1rwl(329);2z2p(91);6fpt(90);6fql(90);6fq3(90);2z2n(89);2z2o(89);2qc5(87);6d69(68);3v64(57);3v65(57);5gje(53);6h15(53);6h16(53);5fww(53);3s8v(53);3s8z(53);4a0p(53);3s2k(53);6fb3(53);6cmx(52);9g41(52);9g2h(52);9g2f(52);9g42(51)
7zpw(0.9641000032);6qsg(0.9542999864)
null
6f0q(501)
1rwi(329)
7zpw(0.9641000032)
1rwl(0.851000011)
2.40.10.500;2.20.25.400;2.40.128.190;2.40.10.360;2.110.10.10;2.20.25.650;2.40.128.630;2.20.25.10
null
6iwb
2019-12-11
other
id:A,C;type:N;source:Homo sapiens;length:157;seq_nat:MHHHHHHGSGQRWELALGRFLEYLSWVSTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEVQAMLGQSTEELRVRLASHLIALQLRLIGDAFDLQKRLAVYQAGAAEQ;seq_unnat:MHHHHHHGSGQRWELALGRFLEYLSWVSTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRG...
17,844.191
P 65
129.718|129.718|80.291|90.000|90.000|120.000
X-RAY DIFFRACTION
null
G. Giordano-Attianese;P. Gainza;E. Gray-Gaillard;E. Cribioli;S. Shui;S. Kim;M.J. Kwak;S. Vollers;A.J. Corria Osorio;P. Reichenbach;J. Bonet;B.H. Oh;M. Irving;G. Coukos;B.E. Correia
"A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy", Nat.Biotechnol., 38, 426-432
10.1038/s41587-019-0403-9|32015549|2119|1087-0156|NABIF9
US
Crystal structure of a computationally designed protein (ld3) in complex with bcl-2
apoptosis
null
null
null
null
null
null
null
null
null
null
6jcc
2019-03-13
other
id:A;type:D;source:synthetic construct;length:98;seq_nat:HHHMTPEQREFLLEILAEIIANLDPTKILEEPLRRGLLTPAELQEVLDLKTPEEQAKKLIDFILKLSPAEAQALIDALRAHGYQALADKLKKYLPLE;seq_unnat:HHHMTPEQREFLLEILAEIIANLDPTKILEEPLRRGLLTPAELQEVLDLKTPEEQAKKLIDFILKLSPAEAQALIDALRAHGYQALADKLKKYLPLE
11,085.901
P 21 21 21
35.321|38.159|64.153|90.00|90.00|90.00
X-RAY DIFFRACTION
null
W. Meng;L. Haiyan
To be published
||||
null
Structure of a de novo protein d_1cy5_m1
de novo protein;designed protein evolution crystal structure helix
2mn4(171)
null
null
null
2mn4(171)
null
7vty(0.6123999953)
5wve(0.643599987)
1.10.533.10;1.10.506.20;1.10.60.30;1.10.260.40
null
6kos
2020-01-29
other
id:A,B,C,D;type:D;source:synthetic construct;length:103;seq_nat:MYGKLNKLVEHIKELLQQLNKNWHRLQSNLHDMLQQMEQLFQEFQHFMQGNQDDGKLQNMIHEMQQFMNQLDNHLQSLSDTVHHFHNKLQELMNNFHHLVHK;seq_unnat:MYGKLNKLVEHIKELLQQLNKNWHRLQSNLHDMLQQMEQLFQEFQHFMQGNQDDGKLQNMIHEMQQFMNQLDNHLQSLSDTVHHFHNKLQELMNNFHHLVHK
12,542.261
P 21 21 21
65.636|71.930|81.563|90.000|90.000|90.000
X-RAY DIFFRACTION
null
N. Kimura;K. Mochizuki;K. Umezawa;M.H. Hecht;R. Arai
"HyperstableDe NovoProtein with a Dimeric Bisecting Topology", Acs Synth Biol, 9, 254-259
10.1021/acssynbio.9b00501|31951376||2161-5063|
US
Crystal structure of suwa (super wa20), a hyper-stable de novo protein with a dimeric bisecting topology
3d domain swapping;binary patterned design;thermostable protein design;four helix bundle;bisecting u topology;de novo protein
3vjf(192);8h7c(103);8h7d(103);8h7e(103)
null
null
null
3vjf(192)
null
3vjf(0.9153000116)
5nfd(0.7498999834)
1.10.287.1520;6.10.140.1300;1.20.5.1430;1.10.287.70;1.10.287.3290;6.10.140.1450;6.10.140.1740;1.10.287.2320;1.10.287.210;1.10.287.450;6.10.140.2090;1.20.20.10;6.10.230.10;1.10.287.710;1.20.58.350;6.10.140.1460;1.10.287.920;1.10.287.1890;6.10.250.190;6.10.140.1720;1.10.287.850;1.10.287.380;1.10.287.3610;1.10.287.1060;1....
null
6m6z
2020-06-24
other
id:A,B,C,D;type:N;source:Escherichia coli;length:205;seq_nat:SAEELLRRSREYLKKVALIQLVIAFVFLILLILLSWRSEELIRELEEKGAASEAELARMKQQHMTAYLQAALTAWEIISKSVIALLLLQQNQLNLELNTDTDKNVAEELLRRSREYLKKVALIQLVIAFVFLILLILLSWRSEELIRELEEKGAASEAELARMKQQHMTAYLQAALTAWEIISKSVIALLLLQQNQLNLELRH;seq_unnat:SAEELLRRSREYLKKVALIQLVIAFVFLILLILLSWRSEELIREL...
23,455.572
P 1
1.00|1.00|1.00|90.00|90.00|90.00
ELECTRON MICROSCOPY
null
C. Xu;P. Lu;T.M. Gamal El-Din;X.Y. Pei;M.C. Johnson;A. Uyeda;M.J. Bick;Q. Xu;D. Jiang;H. Bai;G. Reggiano;Y. Hsia;T.J. Brunette;J. Dou;D. Ma;E.M. Lynch;S.E. Boyken;P.S. Huang;L. Stewart;F. DiMaio;J.M. Kollman;B.F. Luisi;T. Matsuura;W.A. Catterall;D. Baker
"Computational design of transmembrane pores", Nature, 585, 129-134
10.1038/s41586-020-2646-5|32848250|0006|1476-4687|NATUAS
UK
A de novo designed transmembrane nanopore, tmh4c4
nanopore;de novo protein;de novo design;membrane protein
null
null
null
null
null
null
null
null
null
null
6mcd
2020-03-04
other
id:A;type:U;source:unknown;length:38;seq_nat:XEWEALEKKLAACESKAQALEKKLQALEKKLEALEHGX;seq_unnat:(ACE)EWEALEKKLAACESKAQALEKKLQALEKKLEALEHG(NH2)
4,096.766
H 3 2
38.304|38.304|141.141|90.000|90.000|120.000
X-RAY DIFFRACTION
null
A.E. Tolbert;C.S. Ervin;L. Ruckthong;T.J. Paul;V.M. Jayasinghe-Arachchige;K.P. Neupane;J.A. Stuckey;R. Prabhakar;V.L. Pecoraro
"Heteromeric three-stranded coiled coils designed using a Pb(II)(Cys)3template mediated strategy", Nat.Chem., 12, 405-411
10.1038/s41557-020-0423-6|32123337||1755-4349|
UK
Crystal structure of tris-thiolate pb(ii) complex with adjacent water in a de novo three stranded coiled coil peptide
de novo protein;metallopeptide de novo design
5kb2(64);6egp(64);6ego(64);6egl(63);6egm(63);6egn(63);5kb0(61);7n2y(61);5kb1(61);7n2z(61)
null
6egl(1);6egm(1);5kb2(1);6egn(1);6egp(1);6ego(0.9864000082);7n2z(1);5kb0(0.9918000102);7n2y(0.9912999868);5kb1(0.9742000103)
null
5kb2(64)
null
6egl(1)
null
6.10.250.770;1.20.5.420;1.20.5.930;6.10.250.2070;6.10.250.1610;1.20.5.430;6.10.250.810;1.20.5.770;1.20.5.1450;1.20.5.750;1.20.5.700;6.10.250.2720;1.10.287.210;6.10.250.2060;1.20.5.470;6.10.250.110;6.10.250.1090;1.20.5.520;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.850;6.10.250.380;1.20.5.110;1.20.5.25...
null
6mct
2019-04-03
other
id:A,B,C,D,E,F,G,H,I,J,K,L,M,N,O;type:U;source:unknown;length:27;seq_nat:DSLKWIVFLLFLIVLLLLAIVFLLRGX;seq_unnat:DSLKWIVFLLFLIVLLLLAIVFLLRG(NH2)
3,028.867
P 21 21 2
52.894|165.630|41.067|90.00|90.00|90.00
X-RAY DIFFRACTION
null
M. Mravic;J.L. Thomaston;M. Tucker;P.E. Solomon;L. Liu;W.F. DeGrado
"Packing of apolar side chains enables accurate design of highly stable membrane proteins", Science, 363, 1418-1423
10.1126/science.aav7541|30923216|0038|1095-9203|SCIEAS
US
A designed pentameric membrane protein stabilized by van der waals interaction
protein design;de novo protein;membrane protein
null
null
6mpw(1);7udy(1);6mq2(0.9879999757);7udw(0.9980999827);7udv(0.9505000114);7udz(0.9505000114);7udx(0.9505000114)
null
6mpw(43)
null
6mpw(1)
null
null
null
6mk1
2019-06-26
other
id:A,a,B,b,C,c,D,d,E,e,F,f,G,g,H,h,I,i,J,j,K,k,L,l,M,m,N,n,O,o,P,p,Q,q,R,r,S,s,T,t,U,u,V,v,W,w,X,x,Y,y,Z,z;type:U;source:unknown;length:30;seq_nat:DERAVEALIKALKDPDWYVRKAAAEALGRI;seq_unnat:DERAVEALIKALKDPDWYVRKAAAEALGRI
3,374.886
null
|||||
ELECTRON MICROSCOPY
null
S.A. Hughes;F. Wang;S. Wang;M.A.B. Kreutzberger;T. Osinski;A. Orlova;J.S. Wall;X. Zuo;E.H. Egelman;V.P. Conticello
"Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs", Proc.Natl.Acad.Sci.USA, 116, 14456-14464
10.1073/pnas.1903910116|31262809|0040|1091-6490|PNASA6
US
Cryo-em of self-assembly peptide filament heat_r1
filament;self-assembly peptide filament;protein fibril
null
null
null
null
null
null
null
null
null
null
6mpw
2019-04-03
other
id:A,B,C,D,E;type:U;source:unknown;length:27;seq_nat:DSLKWIVFLLFLIVLLLLAIVFLLRGX;seq_unnat:DSLKWIVFLLFLIVLLLLAIVFLLRG(NH2)
3,028.867
C 2 2 21
55.580|88.802|48.207|90.00|90.00|90.00
X-RAY DIFFRACTION
null
M. Mravic;J.L. Thomaston;M. Tucker;P.E. Solomon;L. Liu;W.F. DeGrado
"Packing of apolar side chains enables accurate design of highly stable membrane proteins", Science, 363, 1418-1423
10.1126/science.aav7541|30923216|0038|1095-9203|SCIEAS
US
De novo design of membrane protein--mini-evgl membrane protein, c2221 form-1
pentameric bundle;de novo protein;de novo design;membrane protein
null
null
6mq2(1);7udz(1);7udv(1);7udx(1);7udy(1);7udw(0.9980000257);6mct(1);6mqu(0.967599988)
null
6mct(43)
null
7udz(1)
null
6.10.250.770;6.10.250.1960;1.20.5.420;1.20.5.2620;1.20.5.1450;6.10.250.1560;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1.20.5.250;6.10.250.3...
null
6mq2
2019-04-03
other
id:A,B,C,D,E;type:U;source:unknown;length:27;seq_nat:DSLKWIVFLLFLIVLLLLAIVFLLRGX;seq_unnat:DSLKWIVFLLFLIVLLLLAIVFLLRG(NH2)
3,028.867
C 2 2 21
55.550|81.890|47.840|90.00|90.00|90.00
X-RAY DIFFRACTION
null
M. Mravic;J.L. Thomaston;M. Tucker;P.E. Solomon;L. Liu;W.F. DeGrado
"Packing of apolar side chains enables accurate design of highly stable membrane proteins", Science, 363, 1418-1423
10.1126/science.aav7541|30923216|0038|1095-9203|SCIEAS
US
De novo design of membrane protein--mini-evgl membrane protein, c2221 form-2
de novo protein;helical bundle;de novo design;membrane protein
null
null
7udy(1);6mct(1);6mpw(1);7udw(1);7udv(1);6mqu(0.9672999978);7udz(1);7udx(1)
null
6mct(43)
null
7udy(1)
null
6.10.250.1960;6.10.250.2050;4.10.180.60;1.20.5.640;4.10.180.10;6.10.250.2830;6.10.250.1560;6.10.250.1110
null
6mqu
2019-04-03
other
id:A,B,C,D,E,F,G,H,I,J;type:U;source:unknown;length:33;seq_nat:DPEQLKWISFCLFLICLLLLCIIFMLYRGRGSX;seq_unnat:DPEQLKWISFCLFLICLLLLCIIFMLYRG(DAR)GS(NH2)
3,806.718
I 41
124.230|124.230|51.940|90.00|90.00|90.00
X-RAY DIFFRACTION
null
M. Mravic;J.L. Thomaston;M. Tucker;P.E. Solomon;L. Liu;W.F. DeGrado
"Packing of apolar side chains enables accurate design of highly stable membrane proteins", Science, 363, 1418-1423
10.1126/science.aav7541|30923216|0038|1095-9203|SCIEAS
US
Pl5, synthetic transmembrane domain variant of human phospholamban
phospholamban;pentamer;transmembrane;designed;de novo protein;engineered
null
null
null
null
6mqu(0)
null
7udv(0.9337999821)
null
6.10.250.770;6.10.250.1960;1.20.5.420;1.20.5.2620;1.20.5.1450;6.10.250.1560;1.20.5.700;6.10.250.500;6.10.250.1150;6.10.250.200;6.10.250.2150;6.10.250.880;6.10.250.270;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.2720;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10....
null
6mrr
2019-06-12
other
id:A;type:D;source:synthetic construct;length:68;seq_nat:GWSTELEKHREELKEFLKKEGITNVEIRIDNGRLEVRVEGGTERLKRFLEELRQKLEKKGYTVDIKIE;seq_unnat:GWSTELEKHREELKEFLKKEGITNVEIRIDNGRLEVRVEGGTERLKRFLEELRQKLEKKGYTVDIKIE
8,158.348
P 1 21 1
24.045|43.584|29.276|90.00|99.00|90.00
X-RAY DIFFRACTION
null
B. Koepnick;J. Flatten;T. Husain;A. Ford;D.A. Silva;M.J. Bick;A. Bauer;G. Liu;Y. Ishida;A. Boykov;R.D. Estep;S. Kleinfelter;T. Norgard-Solano;L. Wei;F. Players;G.T. Montelione;F. DiMaio;Z. Popovic;F. Khatib;S. Cooper;D. Baker
"De novo protein design by citizen scientists", Nature, 570, 390-394
10.1038/s41586-019-1274-4|31168091|0006|1476-4687|NATUAS
UK
De novo designed protein foldit1
de novo protein;foldit
null
null
null
null
8y9c(38)
null
8y9b(0.7008000016)
3tuf(0.6105999947)
3.30.300.90;3.30.300.20;3.30.300.70;3.30.70.240;3.30.1360.100;3.30.70.2210;3.30.70.1350;3.30.70.600;3.30.300.50;3.30.70.1770;3.30.70.120;3.30.1340.30
null
6mrs
2019-06-12
other
id:A;type:D;source:synthetic construct;length:77;seq_nat:GSGRQEKVLKSIEETVRKMGVTMETHRSGNEVKVVIKGLHESQQEQLKKDVEETSKKQGVETRIEFHGDTVTIVVRE;seq_unnat:GSGRQEKVLKSIEETVRKMGVTMETHRSGNEVKVVIKGLHESQQEQLKKDVEETSKKQGVETRIEFHGDTVTIVVRE
8,749.917
P 31 2 1
52.414|52.414|56.086|90.00|90.00|120.00
X-RAY DIFFRACTION
null
B. Koepnick;J. Flatten;T. Husain;A. Ford;D.A. Silva;M.J. Bick;A. Bauer;G. Liu;Y. Ishida;A. Boykov;R.D. Estep;S. Kleinfelter;T. Norgard-Solano;L. Wei;F. Players;G.T. Montelione;F. DiMaio;Z. Popovic;F. Khatib;S. Cooper;D. Baker
"De novo protein design by citizen scientists", Nature, 570, 390-394
10.1038/s41586-019-1274-4|31168091|0006|1476-4687|NATUAS
UK
De novo designed protein peak6
de novo protein;foldit
9dd4(99);9dcz(96);9dd0(96);9dcx(96);9olq(96);9dd2(96);9dd3(95);9dcy(95);9dd1(91);7mwr(82);8ure(57)
9drl(82)
null
null
9dd4(99)
9drl(82)
9dcz(0.9004999995)
5iuj(0.5799999833)
3.30.70.1410;3.90.1070.10;3.30.70.990;3.30.70.1710;3.30.300.20;3.30.70.240;3.30.1360.100;3.30.70.2210;3.30.1240.20;3.30.980.10;3.30.70.600;3.30.1370.30;3.90.1070.20;3.30.460.10;3.30.200.20;3.30.70.1770;3.30.1340.30
null
6msp
2019-06-12
other
id:A;type:D;source:synthetic construct;length:98;seq_nat:MGHHHHHHENLYFQSHMTDELLERLRQLFEELHERGTEIVVEVHINGERDEIRVRNISKEELKKLLERIREKIEREGSSEVEVNVHSGGQTWTFNEK;seq_unnat:MGHHHHHHENLYFQSHMTDELLERLRQLFEELHERGTEIVVEVHINGERDEIRVRNISKEELKKLLERIREKIEREGSSEVEVNVHSGGQTWTFNEK
11,725.06
null
|||||
SOLUTION NMR
null
B. Koepnick;J. Flatten;T. Husain;A. Ford;D.A. Silva;M.J. Bick;A. Bauer;G. Liu;Y. Ishida;A. Boykov;R.D. Estep;S. Kleinfelter;T. Norgard-Solano;L. Wei;F. Players;G.T. Montelione;F. DiMaio;Z. Popovic;F. Khatib;S. Cooper;D. Baker
"De novo protein design by citizen scientists", Nature, 570, 390-394
10.1038/s41586-019-1274-4|31168091|0006|1476-4687|NATUAS
UK
De novo designed protein foldit3
de no designed foldit foldit3;de novo protein
null
4zrs(56)
null
null
9n0i(36)
4zrs(56)
7dkk(0.5970000029)
2v6a(0.5220999718)
3.30.1490.240;3.30.360.10;3.30.1490.70;3.30.1490.20;3.30.190.20;2.60.40.1930
null
6msq
2019-05-08
other
id:A,B;type:D;source:synthetic construct;length:76;seq_nat:GSEYEIRKALEELKASTAELKRATASLRAITEELKKNPSEDALVEHNRAIVEHNAIIVENNRIIAAVLELIVRAIK;seq_unnat:GSEYEIRKALEELKASTAELKRATASLRAITEELKKNPSEDALVEHNRAIVEHNAIIVENNRIIAAVLELIVRAIK
8,488.75
P 63
50.566|50.566|130.753|90.00|90.00|120.00
X-RAY DIFFRACTION
null
S.E. Boyken;M.A. Benhaim;F. Busch;M. Jia;M.J. Bick;H. Choi;J.C. Klima;Z. Chen;C. Walkey;A. Mileant;A. Sahasrabuddhe;K.Y. Wei;E.A. Hodge;S. Byron;A. Quijano-Rubio;B. Sankaran;N.P. King;J. Lippincott-Schwartz;V.H. Wysocki;K.K. Lee;D. Baker
"De novo design of tunable, pH-driven conformational changes", Science, 364, 658-664
10.1126/science.aav7897|31097662|0038|1095-9203|SCIEAS
US
Crystal structure of pro-2.3
helical bundle;de novo protein;computational design
6msr(125);8ubg(121);8ub3(120);8uao(116);8glt(107);8cws(98);8cwy(93);5j0h(67);9dkk(67);9cwp(67);9cwr(67);5j0i(59)
9drl(113)
6msr(0.9610000253);8uao(0.9503999949);8cwy(0.9578999877)
null
6msr(125)
9drl(113)
6msr(0.9610000253)
2ic6(0.8830999732)
1.10.287.660;1.10.287.70;6.10.140.1450;1.10.287.210;1.20.20.10;6.10.250.1010;6.10.280.110;6.10.140.1720;1.10.287.540;1.10.287.850;1.10.287.380;1.10.287.740;1.10.287.1060;1.10.287.470;6.10.140.820;1.10.287.170;1.20.5.300;1.10.287.180;6.10.280.160;1.20.58.1710;6.10.140.1340;1.10.287.990;1.20.5.1930;1.20.58.850;1.10.287.1...
null
6msr
2019-05-08
other
id:A,B,C;type:D;source:synthetic construct;length:76;seq_nat:GSEYEIRKALEELKASTAELKRATASLRASTEELKKNPSEDALVENNRLIVEHNAIIVENNRIIAAVLELIVRAIK;seq_unnat:GSEYEIRKALEELKASTAELKRATASLRASTEELKKNPSEDALVENNRLIVEHNAIIVENNRIIAAVLELIVRAIK
8,480.706
C 1 2 1
57.618|33.281|114.455|90.00|99.56|90.00
X-RAY DIFFRACTION
null
S.E. Boyken;M.A. Benhaim;F. Busch;M. Jia;M.J. Bick;H. Choi;J.C. Klima;Z. Chen;C. Walkey;A. Mileant;A. Sahasrabuddhe;K.Y. Wei;E.A. Hodge;S. Byron;A. Quijano-Rubio;B. Sankaran;N.P. King;J. Lippincott-Schwartz;V.H. Wysocki;K.K. Lee;D. Baker
"De novo design of tunable, pH-driven conformational changes", Science, 364, 658-664
10.1126/science.aav7897|31097662|0038|1095-9203|SCIEAS
US
Crystal structure of pro-2.5
helical bundle;de novo protein;computational design
6msq(128);8ub3(113);8ubg(113);8uao(109);8glt(100);8cws(91);8cwy(86);5j0h(74);9dkk(74);9cwp(73);9cwr(73);5j0i(65);6n9h(55);6naf(55)
9drl(106)
6msq(0.9541000128);8uao(0.9593999982)
null
6msq(128)
9drl(106)
8uao(0.9593999982)
2ic6(0.9106000066)
1.10.287.660;6.10.140.630;1.10.287.70;1.10.287.690;1.10.287.3290;1.10.287.120;6.10.140.1450;1.10.287.140;1.10.287.210;1.10.287.450;1.10.287.310;1.20.20.10;6.10.260.10;1.10.287.550;1.20.85.10;6.10.140.1460;1.10.287.230;1.10.287.1890;6.10.250.1010;6.10.280.110;6.10.140.1720;4.10.860.10;1.10.287.540;1.10.287.750;6.10.140....
null
6n4n
2019-09-11
other
id:A,B;type:N;source:Hepacivirus C;length:199;seq_nat:MKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSAGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTMRSP;seq_unnat:MKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIVSTATQTF...
20,915.699
P 1 21 1
70.840|69.256|99.344|90.000|108.590|90.000
X-RAY DIFFRACTION
null
G.W. Foight;Z. Wang;C.T. Wei;P. Jr Greisen;K.M. Warner;D. Cunningham-Bryant;K. Park;T.J. Brunette;W. Sheffler;D. Baker;D.J. Maly
"Multi-input chemical control of protein dimerization for programming graded cellular responses", Nat.Biotechnol., 37, 1209-1216
10.1038/s41587-019-0242-8|31501561|2119|1087-0156|NABIF9
US
Crystal structure of the designed protein dncr2/danoprevir/ns3a complex
procisir;de novo protein/hydrolase/inhibitor;rosetta design;ns3a;de novo protein-hydrolase-inhibitor complex;danoprevir
5cwp(349);8f6r(306);7unj(278);6xss(262);6xi6(130);8tlp(63);8fbi(63);8tm9(62);8evm(61);8fbo(58);7rkc(57);5cwn(56);8e55(55);7rmx(55)
9drl(206)
null
null
5cwp(349)
9drl(206)
8f6r(0.768599987)
3vrn(0.4541000128)
1.10.287.110;1.20.5.420;1.10.287.660;6.10.140.630;6.10.140.1300;1.10.287.3810;1.20.120.870;6.10.140.790;1.10.287.690;1.10.287.120;1.20.930.20;1.20.120.470;1.20.20.10;1.10.287.550;6.10.140.1480;6.10.250.2860;4.10.860.20;1.10.287.230;1.20.1270.90;6.10.250.1010;6.10.280.110;1.20.58.730;4.10.860.10;1.10.287.540;1.10.287.75...
null
6n9h
2019-12-18
other
id:A;type:D;source:synthetic construct;length:80;seq_nat:GSHMGDAQDKLKYLVKQLERALRELKKSLDELERSLEELEKNPSEDALVENNRLNVENNKIIVEVLRIILELAKASAKLA;seq_unnat:GSHMGDAQDKLKYLVKQLERALRELKKSLDELERSLEELEKNPSEDALVENNRLNVENNKIIVEVLRIILELAKASAKLA
9,139.512
P 63
49.986|49.986|67.339|90.00|90.00|120.00
X-RAY DIFFRACTION
null
J. Park;B. Selvaraj;A.C. McShan;S.E. Boyken;K.Y. Wei;G. Oberdorfer;W. DeGrado;N.G. Sgourakis;M.J. Cuneo;D.A. Myles;D. Baker
"De novo design of a homo-trimeric amantadine-binding protein", Elife, 8
10.7554/eLife.47839|31854299||2050-084X|
US
De novo designed homo-trimeric amantadine-binding protein
amantadine-binding protein;de novo protein;helical bundle;trimer
6naf(144);5j0h(105);9dkk(91);9cwp(87);9cwr(87);5j0i(63);6msr(54);8uao(53);8ub3(53);8ubg(53);8glt(51);6msq(50)
9drl(54)
6naf(0.9732999802)
null
6naf(144)
9drl(54)
6naf(0.9732999802)
2ic6(0.913500011)
1.10.287.660;1.10.287.70;1.10.287.310;1.20.20.10;6.10.250.1010;6.10.280.110;4.10.860.10;1.10.287.740;1.10.287.1060;1.10.287.1240;1.10.287.470;6.10.140.820;1.10.287.180;6.10.280.160;1.20.58.1710;1.10.287.80;6.10.140.1340;1.10.287.990;6.10.280.80;1.10.287.130;6.10.280.190;6.10.140.1530;1.10.287.770;1.20.58.90
null
6naf
2019-12-18
other
id:A;type:D;source:synthetic construct;length:80;seq_nat:GSHMGDAQDKLKYLVKQLERALRELKKSLDELERSLEELEKNPSEDALVENNRLNVENNKIIVEVLRIILELAKASAKLA;seq_unnat:GSHMGDAQDKLKYLVKQLERALRELKKSLDELERSLEELEKNPSEDALVENNRLNVENNKIIVEVLRIILELAKASAKLA
9,139.512
P 63
50.610|50.610|68.820|90.00|90.00|120.00
X-RAY DIFFRACTION|NEUTRON DIFFRACTION
null
J. Park;B. Selvaraj;A.C. McShan;S.E. Boyken;K.Y. Wei;G. Oberdorfer;W. DeGrado;N.G. Sgourakis;M.J. Cuneo;D.A. Myles;D. Baker
"De novo design of a homo-trimeric amantadine-binding protein", Elife, 8
10.7554/eLife.47839|31854299||2050-084X|
US
De novo designed homo-trimeric amantadine-binding protein
amantadine-binding protein;de novo protein;helical bundle;trimer
6n9h(144);5j0h(105);9dkk(91);9cwp(87);9cwr(87);5j0i(63);6msr(54);8uao(53);8ub3(53);8ubg(53);8glt(51);6msq(50)
9drl(54)
6n9h(0.9800999761);6msr(0.9610999823)
null
6n9h(144)
9drl(54)
6n9h(0.9800999761)
2ic6(0.9319999814)
1.10.287.660;1.10.287.70;1.10.287.690;1.10.287.3290;1.10.287.120;6.10.140.1450;1.10.287.140;1.10.287.210;1.10.287.310;1.20.20.10;1.20.5.730;1.10.287.550;1.10.287.610;1.10.287.230;1.10.287.1890;6.10.280.110;1.10.287.540;1.10.287.750;1.10.287.850;1.10.287.380;6.10.140.1790;1.10.287.740;1.10.287.1060;1.10.287.1240;1.10.28...
null
6nek
2019-12-25
other
id:A;type:D;source:synthetic construct;length:94;seq_nat:MGWEELTVELEKDGEGLGFSLGDGGIFVSSVVPGGPAARAGRLRVGDRILEVNGVSVEGLTLEEAVKLLRSSGTTVTLTVLRERGGGHHHHHH;seq_unnat:MGWEELTVELEKDGEGLGFSLGDGGIFVSSVVPGGPAARAGRLRVGDRILEVNGVSVEGLTLEEAVKLLRSSGTTVTLTVLRERGGGHHHHHH
9,820.028
I 2 2 2
53.620|60.090|73.300|90.00|90.00|90.00
X-RAY DIFFRACTION
null
Y.J. Sun;M. Sternke;D. Barrick;E.J. Fuentes
To be published
||||
null
Crystal structure of a consensus pdz domain
de novo protein;pdz domain;consensus design
null
1rgr(78);1x5q(74);6esp(74);6mye(73);6myf(73);6ms1(72);2m3m(72);2w4f(72);2oqs(72);5vwc(72);2koj(72);6mtu(72);6mtv(72);5vwk(72);2mho(71);2dlu(71);2kom(71);3gsl(71);6spv(71);6spz(71);1iu0(70);1iu2(70);1kef(70);2ogp(70);2ka9(70);3zrt(70);2xkx(70);2dkr(69);6eey(69);5zds(69);2aww(69);2awx(69);2wl7(68);4h11(68);1uju(68);4wyt(...
null
null
6nek(0)
1rgr(78)
2jre(0.6906999946)
5wou(0.8292000294)
null
null
6nuk
2019-06-12
other
id:A,B;type:D;source:synthetic construct;length:105;seq_nat:MGHHHHHHGWSENLYFQGSTVRIEIRFTNMRREEVQKELEKFKERLKELEKRTGSEIRIEIEERDGEVRVEVEIRNSHEEEVRQIIEEIERWVRKMGGELRVEK;seq_unnat:MGHHHHHHGWSENLYFQGSTVRIEIRFTNMRREEVQKELEKFKERLKELEKRTGSEIRIEIEERDGEVRVEVEIRNSHEEEVRQIIEEIERWVRKMGGELRVEK
12,829.47
P 42 21 2
69.210|69.210|90.590|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B. Koepnick;J. Flatten;T. Husain;A. Ford;D.A. Silva;M.J. Bick;A. Bauer;G. Liu;Y. Ishida;A. Boykov;R.D. Estep;S. Kleinfelter;T. Norgard-Solano;L. Wei;F. Players;G.T. Montelione;F. DiMaio;Z. Popovic;F. Khatib;S. Cooper;D. Baker
"De novo protein design by citizen scientists", Nature, 570, 390-394
10.1038/s41586-019-1274-4|31168091|0006|1476-4687|NATUAS
UK
De novo designed protein ferredog-diesel
de novo protein;foldit
null
null
null
null
9f8y(44)
5ui3(48)
4ney(0.5960999727)
4pxd(0.6406000257)
3.30.70.790;3.30.70.2860;3.30.70.380;3.30.70.1430;3.30.70.870;3.30.1370.10;3.30.70.250;3.30.1360.210;3.30.70.600;3.30.70.3250;3.30.70.1380;3.30.70.1440;3.30.70.340;3.30.70.1130;3.30.70.330;3.30.70.2750;3.30.70.2370;3.30.70.360;3.30.70.1320;3.30.310.50;3.30.70.2690;3.30.70.420;3.30.70.100;3.30.70.120;3.30.70.3400;3.30.7...
null
6nx2
2020-04-22
other
id:A,B,C;type:D;source:synthetic construct;length:99;seq_nat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIENNEAIGGGTKQLEEMKKQLKDLKRSLERG;seq_unnat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIENNEAIGGGTKQLEEMKKQLKDLKRSLERG
11,153.59
C 1 2 1
89.592|51.650|85.527|90.00|110.48|90.00
X-RAY DIFFRACTION
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Crystal structure of computationally designed protein aaa
de novo protein;helix;homotrimer
6o0i(173);6nyi(164);6nz3(160);6nye(160);6nyk(158);6ny8(155);6nxm(155);6o0c(154);6nz1(154)
null
6ny8(0.9973999858);6nz3(0.9763000011)
null
6o0i(173)
null
6ny8(0.9973999858)
3jbp(0.8550000191)
1.10.287.1520;6.10.250.2700;1.10.12.10;1.20.5.4090;4.10.93.10;1.20.5.340;1.20.5.4010;1.10.150.160;1.20.5.1940;1.20.5.730;6.10.250.370;1.20.1270.50;1.20.5.1700;1.20.58.1290;1.10.287.1040;1.20.5.110;1.20.5.620;1.20.5.1180;1.20.58.1200;1.20.5.1500;4.10.280.10;6.20.450.10;1.20.5.170;1.20.5.500;6.10.250.1550;1.20.5.440;1.20...
null
6nxm
2020-04-22
other
id:A,B,C;type:D;source:synthetic construct;length:97;seq_nat:GSHMGDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGVDQKILEEMKKQLKDLKRSLERG;seq_unnat:GSHMGDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGVDQKILEEMKKQLKDLKRSLERG
10,991.57
C 1 2 1
101.045|58.282|58.793|90.000|125.050|90.000
X-RAY DIFFRACTION
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Crystal structure of computationally designed protein xaa_gvdq
de novo protein;helix;homotrimer
6ny8(176);6o0c(175);6nz3(169);6o0i(164);6nz1(161);6nyk(159);6nyi(155);6nx2(154);6nye(151)
null
6nz1(0.9556999803);6nyk(0.9624000192)
null
6ny8(176)
null
6nyk(0.9624000192)
2ic9(0.9034000039)
1.10.287.1520;4.10.910.10;6.10.250.2150;1.20.5.1940;6.10.250.1090;6.10.250.1210;1.20.5.730;6.10.250.160;1.20.5.190;6.10.250.20;6.10.250.490;6.10.250.2630;6.10.250.330;1.20.5.80;6.10.250.1970;6.10.250.30;1.20.5.460;6.10.250.1900;6.10.250.2970;1.20.5.300;6.10.250.1550;6.10.250.2580;6.10.250.1000;1.20.5.450;6.10.250.3070;...
null
6ny8
2020-04-22
other
id:A,B,C;type:D;source:synthetic construct;length:97;seq_nat:GSHMGDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGVDQKILEEMKKQLKDLKRSLERG;seq_unnat:GSHMGDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGVDQKILEEMKKQLKDLKRSLERG
10,991.57
C 1 2 1
86.158|49.602|85.032|90.00|109.71|90.00
X-RAY DIFFRACTION
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Crystal structure of computationally designed protein xaa_gvdq with calcium
de novo protein;helix;homotrimer
6nxm(176);6o0c(175);6nz3(169);6o0i(164);6nz1(161);6nyk(159);6nyi(155);6nx2(154);6nye(151)
null
6nz3(0.9811000228);6nx2(0.9794999957)
null
6nxm(176)
null
6nz3(0.9811000228)
1h2v(0.8525999784)
1.10.287.1520;6.10.250.2700;1.10.12.10;1.20.5.4090;4.10.93.10;1.20.5.340;1.20.5.4010;1.10.150.160;1.20.5.1940;1.20.5.730;6.10.250.370;1.20.1270.50;1.20.5.1700;1.20.58.1290;1.10.287.1040;1.20.5.110;1.20.5.620;1.20.5.1180;1.20.58.1200;1.10.287.1060;1.20.5.1500;4.10.280.10;6.20.450.10;1.20.5.170;1.20.5.500;6.10.250.1550;1...
null
6nye
2020-04-22
other
id:A,B,C;type:D;source:synthetic construct;length:99;seq_nat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVEILALIVENNRAIIEALEAIGGGTKILEEMKKQLKDLKRALERG;seq_unnat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVEILALIVENNRAIIEALEAIGGGTKILEEMKKQLKDLKRALERG
11,061.786
P 21 21 21
35.179|75.322|96.944|90.000|90.000|90.000
X-RAY DIFFRACTION
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Crystal structure of computationally designed protein xax
de novo protein;helix;homotrimer
6o0i(170);6nyk(169);6nyi(161);6nx2(160);6nz3(156);6ny8(152);6nxm(152);6o0c(151);6nz1(151)
null
null
null
6o0i(170)
null
6nyk(0.9186999798)
5och(0.8345000148)
1.10.287.660;1.10.150.160;1.20.5.1940;6.10.140.2090;1.20.58.1290;1.10.287.1040;1.10.287.2500;6.10.280.110;1.10.287.3610;6.10.140.1310;1.10.287.1060;1.20.58.80;1.20.5.170;6.10.140.1570;6.10.280.160;1.10.287.80;1.20.58.860;1.20.58.1000;1.10.287.130;1.20.58.90
null
6nyi
2020-04-22
other
id:A,B,C;type:D;source:synthetic construct;length:99;seq_nat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVEILRAIIEALEAIGGGTKILEEMKKLLKDLKRSLERG;seq_unnat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVEILRAIIEALEAIGGGTKILEEMKKLLKDLKRSLERG
11,077.787
C 1 2 1
129.403|51.213|48.838|90.000|102.450|90.000
X-RAY DIFFRACTION
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Crystal structure of computationally designed protein xxa
de novo protein;helix;homotrimer
6o0i(171);6nz1(169);6nx2(162);6nz3(158);6nye(158);6nyk(156);6ny8(153);6nxm(153);6o0c(153)
null
6nz1(0.9678999782)
null
6o0i(171)
null
6nz1(0.9678999782)
1dov(0.736800015)
1.10.287.660;1.10.150.160;1.20.5.1940;1.20.58.1290;6.10.250.1010;6.10.280.110;1.10.287.1040;1.20.58.1200;1.10.287.740;1.10.287.3610;6.10.140.1310;1.10.287.1060;6.10.140.820;1.10.287.470;1.20.5.170;1.10.287.940;6.10.280.170;6.10.280.160;1.10.287.80;1.20.58.860;1.20.58.340;1.20.58.1000;1.10.287.130;1.20.58.90
null
6nyk
2020-04-22
other
id:A,B,C;type:D;source:synthetic construct;length:99;seq_nat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVEILAQIVENNRAIIEALEAIGGDQKILEEMKKQLKDLKRALERG;seq_unnat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVEILAQIVENNRAIIEALEAIGGDQKILEEMKKQLKDLKRALERG
11,161.817
C 1 2 1
95.416|55.002|57.906|90.000|123.380|90.000
X-RAY DIFFRACTION
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Crystal structure of computationally designed protein xax_ggdq
de novo protein;helix;homotrimer
6nye(170);6o0i(168);6ny8(160);6nxm(160);6nz3(160);6o0c(159);6nyi(159);6nz1(158);6nx2(158)
null
null
null
6nye(170)
null
6nye(0.939800024)
3txq(0.7969999909)
1.20.58.1200;1.10.287.80;6.10.140.2110;6.10.140.1310;1.10.287.1060;1.20.58.860;1.20.58.1290;1.20.58.1000;1.20.5.170;1.10.287.130;1.10.287.1040;1.20.58.90;1.10.150.160;1.20.5.1940
null
6nz1
2020-04-22
other
id:A,B,C,D,E,F;type:D;source:synthetic construct;length:99;seq_nat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVEILRAIIEALEAIGVDQKILEEMKKLLKDLKRSLERG;seq_unnat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVEILRAIIEALEAIGVDQKILEEMKKLLKDLKRSLERG
11,204.926
P 1 21 1
50.647|76.747|91.946|90.000|106.060|90.000
X-RAY DIFFRACTION
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Crystal structure of computationally designed protein xxa_gvdq
de novo protein;helix;homotrimer
6nyi(171);6o0i(163);6ny8(161);6nxm(161);6o0c(160);6nyk(157);6nz3(154);6nx2(153);6nye(150)
null
6nyi(0.9735999703)
null
6nyi(171)
null
6nyi(0.9735999703)
3dkq(0.8309000134)
1.10.287.660;1.10.287.650;1.10.150.160;1.20.5.1940;1.20.1270.50;1.20.58.1290;6.10.280.110;1.10.287.1040;1.20.58.1200;1.10.287.740;1.10.287.3610;6.10.140.1310;1.10.287.1060;6.10.140.820;1.10.287.470;1.20.5.170;6.10.140.1570;6.10.280.160;1.10.287.80;1.20.58.860;1.20.58.340;1.20.58.1000;1.10.287.130;1.20.58.90
null
6nz3
2020-04-22
other
id:A,B,C;type:D;source:synthetic construct;length:97;seq_nat:GSHMGDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGGHNKILEEMKKQLKDLKRSLERG;seq_unnat:GSHMGDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGGHNKILEEMKKQLKDLKRSLERG
10,958.525
C 1 2 1
88.741|51.271|85.873|90.000|110.080|90.000
X-RAY DIFFRACTION
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Crystal structure of computationally designed protein xaa_gghn
de novo protein;helix;homotrimer
6ny8(168);6nxm(168);6o0c(168);6o0i(168);6nyi(159);6nyk(158);6nx2(158);6nye(155);6nz1(154)
null
6ny8(0.9708999991);6nx2(0.9582999945)
null
6ny8(168)
null
6ny8(0.9708999991)
2ic6(0.8442000151)
1.10.287.1520;6.10.250.2700;1.10.12.10;1.20.5.4090;4.10.93.10;1.20.5.340;1.20.5.4010;1.10.150.160;1.20.5.1940;1.20.5.730;6.10.250.370;1.20.1270.50;1.20.5.1700;1.20.58.1290;1.10.287.1040;1.20.5.110;1.20.5.620;1.20.5.1180;1.20.58.1200;1.10.287.1060;1.20.5.1500;4.10.280.10;1.20.5.170;1.20.5.500;6.10.250.1550;1.20.5.440;1....
null
6o0c
2020-04-22
other
id:A,B,C;type:D;source:synthetic construct;length:97;seq_nat:GSHLGDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGVDQKILEEMKKQLKDLKRSLERG;seq_unnat:GSHLGDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGVDQKILEEMKKQLKDLKRSLERG
10,973.532
null
|||||
SOLUTION NMR
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Nmr ensemble of computationally designed protein xaa_gvdq mutant m4l
de novo protein
6ny8(175);6nxm(175);6nz3(168);6o0i(163);6nz1(160);6nyk(158);6nyi(154);6nx2(153);6nye(150)
null
null
null
6ny8(175)
null
6nz1(0.8669000268)
3jbp(0.7369999886)
6.10.280.160;1.10.287.80;6.10.140.1310;1.10.287.1060;1.20.58.860;1.20.58.1290;1.20.5.170;1.10.287.130;1.10.287.1040;6.10.280.110;1.20.58.90;1.10.150.160;1.20.5.1940
null
6o0i
2020-04-22
other
id:A,B,C;type:D;source:synthetic construct;length:99;seq_nat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGGGTKILEEMKKQLKDLKRSLERG;seq_unnat:GSHMGTEDLKYSLERLREILERLEENPSEKQIVEAIRAIVENNAQIVEAIRAIVENNAQIVENNRAIIEALEAIGGGTKILEEMKKQLKDLKRSLERG
11,094.648
null
|||||
SOLUTION NMR
null
K.Y. Wei;D. Moschidi;M.J. Bick;S. Nerli;A.C. McShan;L.P. Carter;P.S. Huang;D.A. Fletcher;N.G. Sgourakis;S.E. Boyken;D. Baker
"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds", Proc.Natl.Acad.Sci.USA, 117, 7208-7215
10.1073/pnas.1914808117|32188784|0040|1091-6490|PNASA6
US
Nmr ensemble of computationally designed protein xaa
de novo protein
6nyi(172);6nx2(171);6nz3(168);6nye(168);6nyk(166);6ny8(163);6nxm(163);6o0c(162);6nz1(162)
null
null
null
6nyi(172)
null
6naf(0.8384000063)
5udo(0.7321000099)
6.10.140.130;1.10.287.660;1.20.58.410;1.10.150.160;6.10.140.1740;1.20.5.1940;1.20.58.1290;6.10.280.110;1.20.58.1200;1.10.287.740;1.10.287.3610;6.10.140.1310;1.10.287.1060;1.20.5.170;6.10.280.160;1.10.287.80;1.20.1270.390;1.20.58.860;1.20.58.1000;1.10.287.130;1.20.58.90
null