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[ [ "we review recent data on glp-1ras to help better understand their current risk / benefit profile and provide primary care practitioners with guidance on how this evidence can inform their clinical practice .", "this rapid increase in the prevalence of t2 dm in asia has been fuelled by urbanization , econ...	glucagon - like peptide-1 receptor agonists ( glp-1ras ) reduce glycosylated hemoglobin ( hba1c , 0.5% to 1.0% ) , and are associated with moderate weight loss and a relatively low risk of hypoglycemia . there are differences between asian and non - asian populations . we reviewed available data on glp-1ras , focusing ...
[ [ "this article is the first to describe the restoration of maxillary defects with inflatable obturator prostheses based on silicone , which also represented an alternative technique for maxillofacial rehabilitation .", "a recent survey showed that oral cancer , which accounts for 2.8% of all malignant tumo...	the presence of a large palatal or maxillary defect after partial or total maxillectomy for tumor , trauma or congenital deformation poses a challenge to prosthodontists , particularly when the use of an implant can not be considered . this case report described the use of an air valve in a hollow silicone obturator to...
[ [ "the targets included in this report were the percent of diabetic subjects with the last a1c 7.5% , with last blood pressure 145/85 mmhg , or with the last measured total cholesterol 5 mmol / l .", " exceptions arise because practices are permitted to identify some individuals as ineligible for evaluation...	objective to evaluate diabetes outcomes under a national pay - for - performance program.research design and methods data were analyzed for 98% of all english family practices . for each practice , the proportion of diabetic subjects with a1c 7.5% , blood pressure 145/85 mmhg , and cholesterol 5 mmol / l was determi...
[ [ "facchinetti et al . discovered that the physiological mi / dci ratio was 40 : 1 and , based on this finding , as well as on the specific behavior of both stereoisomers , we investigated the effects of a therapy that combines mi plus dci in the ratio of 40 : 1 , versus placebo , in order to improve some...	introduction . we evaluated the effects of a therapy that combines myo - inositol ( mi ) and d - chiro - inositol ( dci ) in young overweight women affected by polycystic ovary syndrome ( pcos ) , characterized by oligo- or anovulation and hyperandrogenism , correlated to insulin resistance . methods . we enrolled 46 p...
[ [ "the aim of this study was to identify potential risk factors for cm to inform future clinical research and possible prevention interventions .", "based on a previous case - series work , we hypothesized that breastfeeding and reproductive factors would have important associations with diagnosis of cm .",...	chronic mastitis is a prolonged inflammatory breast disease , and little is known about its etiology . we identified 85 cases and 112 controls from 5 hospitals in morocco and egypt . cases were women with chronic mastitis ( including periductal , lobular , granulomatous , lymphocytic , and duct ectasia with mastitis ) ...
[ [ "the clinical application of cancer genomics should be considered in the context of unmet clinical needs to maximize the value of this novel paradigm . here , we dealt with the potential clinical application of cancer genomics in the aspect of practical management of cancer patients , along with a clinical sc...	the large amount of data on cancer genome research has contributed to our understanding of cancer biology . indeed , the genomics approach has a strong advantage for analyzing multi - factorial and complicated problems , such as cancer . it is time to think about the actual usage of cancer genomics in the clinical fiel...
[ [ "transcriptional activation of adhesion molecules , on the other hand , enables circulating leukocytes to attach to the endothelium and establish a pro - inflammatory microenvironment .", "therefore , elucidation of the mechanisms underlying these characteristic transcriptional events will potentially fur...	atherosclerosis is a progressive human pathology that encompasses several stages of development . endothelial dysfunction represents an early sign of lesion within the vasculature . a number of risk factors for atherosclerosis , including hyperlipidemia , diabetes , and hypertension , target the vascular endothelium by...
[ [ "therefore , this study aimed to evaluate the efficacy of intraoral application of lllt \n ( 660 nm ) in controlling pain intensity , swelling and interincisal opening in oral \n surgery .", "the lllt protocol should be determined considering the type of light used as well as the \n tissue layers that ne...	[ purpose ] this study aimed to evaluate the anti - inflammatory and analgesic effects of intraoral application of low - level laser therapy ( 660 nm ) to control pain , swelling and interincisal opening following the extraction of mandibular third molars . [ subjects and methods ] ten patients underwent removal...
[ [ "the transversus abdominis plane ( tap ) block provides effective post - operative analgesia after abdominal surgery .", "rafi first described tap block , who injected local anesthetic through the ilio - lumbar triangle of petit within the tap between the internal oblique muscle and transversus abdominis ...	although transversus abdominis plane ( tap ) block is an effective way of providing analgesia in post - operative abdominal surgery patients ; however , it can be considered as an anesthetic technique in high - risk cases for surgery . we report a case of a geriatric female with chronic obstructive pulmonary disease in...
[ [ "the mr images were graded for extent and severity of cortex and white matter vasogenic edema , degree of confluence , mass effect and ventricular distortion on a scale from 1 to 5 .", "a retrospective review of clinical records of late postpartum eclampsia patients who had presented with acute onset of v...	the purpose of this study was to determine the prevalence of visual disturbances in patients with posterior reversible encephalopathy syndrome ( pres ) associated with late postpartum eclampsia . we retrospectively reviewed the clinical records of late postpartum eclampsia patients with features of pres for the presenc...
[ [ "isotretinoin is a systemic synthetic retinoid used to treat moderate to severe nodulocystic acne vulgaris that is not responding to other therapies , as well as a number of other dermatologic diseases , including psoriasis , hidradenitis suppurativa , ichthyosis , lesions associated with lupus erythematosus ...	isotretinoin , a drug used for moderate to severe acne , has been repeatedly associated with various psychiatric complications , although a definitive causal relationship has not been established to date . this case report describes a 25-year - old male who developed obsessive - compulsive disorder at the age of 23 yea...
[ [ "furthermore , several studies have suggested that supplementations of herbal extracts such as ginkgo biloba , bauhinia variegata , pongamia pinnata flower , and grape seed may attenuate gm - induced nephrotoxicity .", "althaea officinalis ( marshmallow , marshmallow , or a common marshmallow ) , the memb...	background : gentamicin ( gm ) is used as antibiotic for gram - negative infections , but its administration is limited due to a side - effect of nephrotoxicity . it was attempted to investigate the effect of althaea officinalis flower extract ( aofe ) against nephrotoxicity induced by gm in male rats.methods:30-year-o...
[ [ "items for four concepts identified in the literature were glucose control , well - being and side - effects , lifestyle burden , and treatment complexity and convenience and were evaluated in a series of five focus groups made up of five to eight patients drawn from an evaluation study of community d...	objective to develop and test a patient questionnaire on treatment satisfaction with diabetes regimens.research design and methods survey items were developed from community clinic focus groups , pretested in patients with diabetes , and examined in two samples of treated patients.resultssixteen items performed well ...
[ [ "ie is located on the tricuspid valve in 46 to 58% of patients with iv drug abuse .", "tee is superior to tte for detecting invasive infection in patients with nve and prosthetic valve endocarditis ( pve ) .", "the risk of ie among iv drug abusers , 2 to 5% per patient - years , is several - fold grea...	infective endocarditis is a serious complication of intravenous ( iv ) drug abuse , with a reported mortality of 5 to 10% . a 21-year - old man , who was an intravenous drug abuser , presented with fever and dyspnea . transthoracic echocardiography showed a highly mobile , large vegetation on the anterior leaflet of th...
[ [ "the peritraumatic distress scale ( pds ) was used to assess emotional , cognitive , and physical reactions occuring during a critical incident and immediatly after .", "number of exposure to critical incidents ranged from 2 to 670 ( mean [ m]= 171.27 , sd=130.93).the incident selected for completing the ...	posttraumatic stress disorder ( ptsd ) occurs when significant intrusion , avoidance , and hyperarousal symptoms are manifest for at least 1 month following exposure to a traumatic event , with at least 1 month following exposure to a traumatic event , with at least 1 month elapsed betwenn the event and the diagnossis ...
[ [ "the present study identifies the potential impact of application of open source software in developing national electronic health record in iran .", ", the application of oss in the establishment of national ehr and other health information systems would create a great opportunity to improve national hea...	abstractelectronic health record ( ehr ) is a repository of patient health information shared among multiple authorized users . as a modern method of storing and processing health information , it is a solution for improving quality , safety and efficiency of patient care and health system . however , establishment of ...
[ [ "the purpose of this study was to evaluate the role of angiogenesis in the pathogenesis of olp , using cd34 stain to highlight the blood vessels for measuring the mvd .", "better understanding of the etiopathological mechanism underlying olp will help in the development of new treatment strategies , as we...	background : the etiology of oral lichen planus ( olp ) is not fully understood . it is generally considered to be a t - cell mediated chronic inflammatory oral mucosal disease . there is increasing evidence that chronic inflammation is linked to the diseases associated with endothelial dysfunction and is involved in t...
[ [ "the aim of the present study was to evaluate the impact of aging on saccular function using cvemp response . \n", "however , little is known about the influence of aging on the function of otolith organ . in recent years", "\n age - related structural and functional deterioration of sensory and motor...	background : aging can cause loss of balance , which may lead to physical and psychological problems . as the role of the otolith organs in maintaining postural stability has been emphasized in recent years , the present study investigated the effect of aging on saccular function using cervical vestibular evoked my...
[ [ "malaria testing ( conducted in sierra leone only ) was performed at each laboratory site using the commercially available binaxnow rapid diagnostic test , which identifies 4 plasmodium species : falciparum , malariae , vivax , and ovale . throughout hospitalization ,", "this retrospective , cohort study ...	summary.in a large , retrospective cohort of ebola virus infected children aged < 18 years , the odds of death were 5-fold higher if patients were aged < 5 years , had evidence of bleeding , or real - time polymerase chain reaction cycle threshold value 20 .
[ [ "our study was carried out to highlight the spectrum of perforation peritonitis ( diffuse ) in a single unit at lok nayak hospital , a tertiary care hospital in delhi .", "management of these patients continues to be highly demanding despite the advances made in diagnosis and surgical therapy .", "\n ...	background . perforation peritonitis is the one of the commonest emergency encountered by surgeons . the aim of this paper is to provide an overview of the spectrum of perforation peritonitis managed in a single unit of a tertiary care hospital in delhi . methods . a retrospective study was carried out between may 2010...
[ [ "we hereby describe a young girl who developed lesions of lichen planus pemphigoides ( lpp ) over preexisting atrophic scars , an example of wolf 's isotopic response . to the best of our knowledge , such a clinical presentation of lichen planus ( lp ) pemphigoides is not documented yet in the english liter...	an 18-year - old girl presented with multiple itchy hyperpigmented papules and plaques , along with tense blisters over the lower limbs and buttocks for last 3 months . these papules , plaques , and bullae were mostly localized to preexisting scars . the histopathological findings from papule and bulla were consistent ...
[ [ "charcoal was originally used for localizing a non - palpable tumor mass ( 1 ) , however , it is being increasingly used for localizing suspicious metastatic cervical lymph nodes or recurrent tumors in the thyroid bed after surgery ( 2).although , charcoal is known to be safe and stable when injected subcutan...	charcoal can be used for preoperative localization of metastatic lymph nodes in the neck . charcoal remains stable without causing foreign body reactions during as hort period . however , foreign body reactions may develop if charcoal is left in situ for more than 6 months . we reported a case of charcoal granuloma mim...
[ [ "lns is a rare x - linked recessive disorder , resulting from a mutation on the gene encoding for the enzyme hypoxanthine - guanine phosphoribosyltransferase ( hgprt ) , located on the long arm of the x chromosome between xq26 and xq27 .", "lesch - nyhan syndrome was first recognized and clinically charac...	lesch - nyhan syndrome , described in 1964 by lesch and nyhan , is a x - linked recessive disorder , occurring in 1 : 100000 to 1 : 380000 live births . lns is characterized by a decrease in activity of hypoxanthine guanine phosphoribosyl transferase , an enzyme involved in purine metabolism , resulting in overprod...
[ [ "it well also compares some of the research done on scorpions from different parts of the world to highlight open areas of interest .", "this review will focus on scorpion venom and its major toxins and their functions in excitable cells ." ], [ "table 3 shows the summarized characteristics of the...	scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions , as well as chemical compositions , toxicity , and pharmacokinetic and pharmacodynamic characteristics . these venoms are associated with high morbility and mortality , especially among children . vict...
[ [ "the knowledge of cytokine function has not only contributed to the development of supportive therapies ( i.e. , erythropoietin ( epo ) ) , but dysregulation of cytokines also argues in the diagnosis of some hematopoietic disorders . for example , one of the minor criteria of polycythemia vera ( pv ) accordin...	cytokines are well known mediators of numerous physiological and pathological processes . they contribute to the regulation of normal hematopoiesis but increasing data suggest that they also have a clinical impact in some hematopoietic malignancies . in particular , there is evidence that cytokines are implicated in th...
[ [ "determination of effect of bagv in oviposition and life cycle of mosquitoes : culex quinquefasciatus and cx .", "determination of jev / wnv replication in bagv infected mosquitoes : the influence of bagv in replication of jev and wnv was studied using two methods . in the first method , mosquitoes were i...	background & objectives : studies have shown that certain flaviviruses influence susceptibility of mosquitoes by inhibiting / enhancing replication of important flaviviruses . hence , a study was designed to determine whether bagaza virus ( bagv ) , a flavivirus isolated from culex tritaeniorhynchus mosquitoes in india...
[ [ "signature peptide based quantification of proteins using liquid chromatography - tandem mass spectrometry ( lc - ms / ms ) is increasingly used to measure endogenous or therapeutic proteins because it is a high - throughput , selective , and sensitive method when compared with other quantitative proteomics a...	we studied the precision of quantification of organic anion - transporting polypeptide 1b1 ( oatp1b1 ) , oatp1b3 , oatp2b1 , and p - glycoprotein ( p - gp ) in human livers by surrogate peptide based lc - ms / ms approach using two different internal standards : stable isotope labeled peptide ( sil ) versus stable isot...
[ [ "our objectives for this study were to determine whether abnormal cgm results are associated with subsequent development of cfrd , lung function , and bmi decline and increased rate of cf pulmonary exacerbations .", "advances in treatment have led to an increase in survival in people with cystic fibrosis ...	rationale . cystic fibrosis related diabetes ( cfrd ) is the most common comorbidity in patients with cf . in spite of increased screening , diagnosis , and treatment of cfrd , the mortality rate in patients with cfrd still far exceeds the mortality rate in those without cfrd . guidelines suggest that screening for cfr...
[ [ ". \n the baff / april axis plays an important role in the pathogenesis of various autoimmune diseases including sle ; inhibitors of this axis are therefore useful in treatment of these disordersresults from bliss-52 and bliss-76 trials have shown belimumab to be efficacious in treating patients with sleserio...	belimumab is the only approved biological agent for the treatment of systemic lupus erythematosus ( sle ) . it is a fully humanized igg1 monoclonal antibody directed against soluble b lymphocyte stimulator ( blys ) . it is indicated as an add - on therapy for the treatment of adult patients with active , autoantibody -...
[ [ "a standard approach to therapy is to surgically remove surgically as much of the tumor(s ) as possible , a process known as surgical cytoreduction .", "the following sections describe our approach to using the jnkk1/mkk4 metastasis suppressor to dissect molecular events governing omental metastatic colon...	ovarian cancer affects approximately 25,000 women in the united states each year and remains one of the most lethal female malignancies . a standard approach to therapy is surgical cytoreduction , after which the remaining microscopic residual disease is treated with chemotherapy . the vast majority of patients have di...
[ [ "in this study we evaluated the extent to which [ f]fdg pet imaging can accurately characterize the antitumor activity of enzastaurin in two different mouse xenograft tumor models .", "recently , enzastaurin has shown antitumor activity in xenograft models of the colorectal cancer cell line hct116 and in ...	background . the use of 2-[18f]fluoro-2-deoxy - d - glucose ( [ 18f]fdg ) may help to establish the antitumor activity of enzastaurin , a novel protein kinase c - beta ii ( pkc-ii ) inhibitor , in mouse xenografts . methods . the hematologic cell line raji and the solid tumor cell line u87 mg were each implanted in nod...
[ [ "review articles in the scientific literature can be classified as a general review article , a systematic review ( sr ) , or meta - analysis ( ma ) .", "the purpose of a review article is to provide readers with a summary of published research in a particular field", "a general review article attempt...	systematic reviews are currently favored methods of evaluating research in order to reach conclusions regarding medical practice . the need for such reviews is necessitated by the fact that no research is perfect and experts are prone to bias . by combining many studies that fulfill specific criteria , one hopes that t...
[ [ "histologically , it presents as a well - circumscribed tumor composed of cementum like tissue surrounded by a fibrous capsule .", "cementoblastoma in the current world health organization classification of odontogenic tumor , is in the category of tumors of mesenchyme and/or odontogenic ectomesenchyme wi...	we present a rare case of radiopaque lesion with radiolucent rim in the right body of mandible , with history of extraction of involved tooth , which made diagnosis confusing unless pre - extraction intraoral periapical radiography radiograph was recovered , finally diagnosed as benign cementoblastoma . it was surgical...
[ [ "the amber99 force field overestimates the fraction of syn conformations for the base orientation and of c2-endo sugar puckering of the pyrimidines , while the results of amber99 are more consistent with that of the experimental nmr data .", "simulations on adenosine ( a ) and guanosine ( g ) show that am...	a reparameterization of the torsional parameters for the glycosidic dihedral angle , , for the amber99 force field in rna nucleosides is used to provide a modified force field , amber99. molecular dynamics simulations of cytidine , uridine , adenosine , and guanosine in aqueous solution using the amber99 and amber99 f...
[ [ "however , in most countries the main source of fructose is from sucrose , a disaccharide composed of equal portions of fructose and glucose . in the united states another major source of fructose is high - fructose corn syrup ( hfcs ) , which is a commercial liquid product consisting of fructose and glucose ...	fructose is a sugar present in sucrose , high - fructose corn syrup , honey , and fruits . fructose intake has increased markedly in the last two centuries , primarily due to increased intake of added sugars . increasing evidence suggests that the excessive intake of fructose may induce fatty liver , insulin resistance...
[ [ "timeline of investigation of secondary and tertiary transmission of vaccinia virus from a us military service member , new york , usa , 2010 .", "on february 23 , 2010 , a military service member preparing for deployment received smallpox vaccination and was counseled by the us department of defense abou...	during february and march 2010 , the new york state department of health investigated secondary and tertiary vaccinia contact transmission from a military vaccinee to 4 close contacts . identification of these cases underscores the need for strict adherence to postvaccination infection control guidance to avoid transmi...
[ [ "we have \n performed x - ray absorption near - edge structure ( xanes ) , x - ray and \n ultraviolet photoelectron spectroscopy ( xps / ups ) , and scanning tunneling \n microscopy ( stm ) to determine the effects of adsorption of nio onto \n the sto(110)-(4 1 ) surface .", "nio was prepared by either (...	nickel oxide ( nio ) , deposited onto the strontium titanate ( srtio3 ) ( 110)-(4 1 ) surface , was studied using photoemission spectroscopy ( pes ) , x - ray absorption near edge structure ( xanes ) , and low - energy he+ ion scattering ( leis ) , as well as scanning tunneling microscopy ( stm ) . the main mo...
[ [ "we report an anti - gbm antibody - positive patient with fgn associated with tma .", "anti - glomerular basement membrane ( gbm ) antibody glomerulonephritis is considered to be a glomerular nephritis of a systemic disease . here ,", "according to the world health organization 's classification of gl...	we present the first report of a case of fibrillary glomerulonephritis ( fgn ) associated with thrombotic microangiopathy ( tma ) and anti - glomerular basement membrane antibody ( anti - gbm antibody ) . a 54-year - old man was admitted to our hospital for high fever and anuria . on the first hospital day , we initiat...
[ [ "recently , the broad acceptance of novel bloodbased biomarkers has emerged in the arena of risk stratification , even though the true incremental value of such measures in routine clinical practice has been challenged in populationbased studies .", "traditionally , the presence of specific clinical signs...	backgroundfew studies have investigated functional capacity selfassessment tools in either prediction of future major adverse cardiac outcomes beyond allcause mortality or direct comparisons with clinically available biomarkers.methods and resultswe estimated functional capacity using the duke activity status index ( d...
[ [ "eph is the most dramatic operation in modern obstetrics and is generally performed when all conservative measures have failed to achieve haemostasis in the setting of life threatening hemorrhage . the unplanned nature of the surgery and the need for performing it expeditiously , compound matters .", "eme...	background : peripartum hysterectomy is a major operation and is invariably performed in the presence of life threatening hemorrhage during or immediately after abdominal or vaginal deliveries.material and methods : a medline search was conducted to review the recent relevant articles in english literature on emergency...
[ [ "i ( n=25 ) , 250 mg bupivacaine 0.5% and 400 g fentanyl in 150 cc saline 0.9% and in group ii ( n=25 ) , 250 mg levobupivacaine 0.5% and 400 g fentanyl in 150 cc saline 0.9% was infused via epidural pca .", "0.25% bupivacaine in 10 ml for group i and 0.25% levobupivacaine for group ii was injected via ep...	background : opioid and local anesthetic infusion by an epidural catheter is widely used as a postoperative pain management method after major abdominal surgeries . there are several agents nowadays to provide sufficient analgesia . the agents which cause less side effects but better quality of analgesia are more valua...
[ [ "encouragingly , the majority of these studies reported good hrqol and functional status post - icu , although some discordance was evident , suggesting a change in conceptualization of quality of life following critical illness .", "they urge the need for further research , which must be well designed , ...	tracheostomies have been around for close to 3000 years , so one would hope that the controversies might have been thrashed out by now , but apparently not . judging by some recent publications it would appear that we still do not know when or how to insert them . monitoring is fundamental to critical care ; two papers...
[ [ "the premise of d is that the availability of simple , inexpensive equipment and procedures for each of the core scientific drug discovery disciplines ( computational chemistry , synthetic chemistry , and biochemical screening ) will enable large drug discovery problems to be broken down into manageable small...	distributed drug discovery ( d3 ) proposes solving large drug discovery problems by breaking them into smaller units for processing at multiple sites . a key component of the synthetic and computational stages of d3 is the global rehearsal of prospective reagents and their subsequent use in the creation of virtual cata...
[ [ "liquid - based cytology ( lbc ) as a technique was introduced and tried on pap smears .", "thereafter , this technique was performed for non - gynecological cytology , including conventional fine needle aspiration cytology ( fnac ) , guided fnac and fluid cytology .", ". the pathologist should be cau...	background : liquid - based cytology ( lbc ) is fast becoming a useful method in evaluating both gynecological and non - gynecological preparations , including fine needle aspiration ( fna ) cytology . even distribution of cells , decreasing obscuring background elements like blood and mucus , well preserved nuclear an...
[ [ "we used multivariate logistic regressions to evaluate the association between mets and svr after adjusting for age , smoking , alcohol consumption , bmi , menopausal status , and hormonal replacement therapy ( women only ) .", "the vat area was defined as intra - abdominal fat bound by parietal peritoneu...	objectivethis study aimed to assess the correlation between abdominal subcutaneous adipose tissue ( sat ) and metabolic syndrome ( mets ) in korean adults after adjusting for the effects of visceral adipose tissue ( vat).research design and methodsthe sat / vat ratio ( svr ) was calculated using abdominal computed tomo...
[ [ "thus , the present study was aimed to investigate the therapeutic effects of zm for treatment of oral aphthous lesions .", "recurrent aphthous stomatitis ( ras ) is the most common recurrent lesion of the oral epithelium .", "it also has been reported that the eos and extracts of zm can stimulate inn...	background : aphthous lesions are one of the most common diseases of the oral cavity . they can cause severe pain , and there is no definite treatment . the purpose of this study was to determine the efficacy of zataria multiflora ( zm , a thyme - like plant ) essential oil for the control and treatment of aphthous les...
[ [ "many studies have demonstrated considerable effects of diabetes mellitus ( dm ) on all the layers of the cornea .", "it has the ability to assess corneal endothelium features and measure cct at the same time with accuracy of 10 m.7 the aim of this study was to compare corneal ecd , morphological features...	purposethis study was conducted to compare the corneal endothelial cell density ( ecd ) , morphological features , and central corneal thickness ( cct ) in type 2 diabetes mellitus ( dm ) with age - matched , nondiabetic control subjects using em-3000 specular microscope.study designthis was a prospective , hospital - ...
[ [ "the purpose of this study was to investigate the antimicrobial action of ciprofloxacin hydrochloride and metronidazole , and the vehicles polyethylene glycol and natrosol , either alone or associated , supported by the fact that intracanal medication is an important adjuvant of the endodontic treatment proto...	in some situations , endodontic infections do not respond to therapeutic protocol . in these cases , it is suggested the administration of an alternative intracanal medication that presents a wide spectrum of action and has an in - depth effect on the root canal system . the purpose of this study was to assess the anti...
[ [ "breast stage b2 corresponded to the breast bud stage with palpable glandular breast tissue and elevation of the papilla , stage b3 with further enlargement of the breast and areola with no separation of the contours , stage b4 where the areola and papilla form a secondary mound above the level of the breast ...	background : this study aimed to compare the timing of puberty between various geographic locations and different ethnicities.methods:this national survey was conducted in 20 provinces in iran . healthy iranian girls were selected from public schools using cluster random sampling . a total number of 30 clusters includi...
[ [ "indeed , mln4924 , a selective inhibitor of nae , has potent tumor - suppressing activity in a wide range of tumors , including acute myeloid leukemia and diffuse large b cell lymphomas , .", "notably , bortezomib has been used successfully as an anticancer drug for multiple myeloma and mantle cell lymph...	ubiquitination is crucial for cellular processes , such as protein degradation , apoptosis , autophagy , and cell cycle progression . dysregulation of the ubiquitination network accounts for the development of numerous diseases , including cancer . thus , targeting ubiquitination is a promising strategy in cancer thera...
[ [ "the present study therefore aimed to identify the actual gastrointestinal fauna in these free - ranging sea lions within their natural habitat in the river of the city of valdivia , chile , and to gain some insights in their potential zoonotic impact on public health issues .", "the south american sea li...	the present study represents the first report on the gastrointestinal endoparasite fauna of a free - ranging urban colony of south american sea lions ( otaria flavescens ) living within the city of valdivia , chile . a total of 40 individual faecal samples of south american sea lions were collected during the year 201...
[ [ "in 2014 , the szent - gyrgyi prize for progress in cancer research was awarded to james allison , phd , chairman of the department of immunology at the university of texas md anderson cancer center ( figure 3 ) .", "this year 's szent - gyrgyi prize celebrates the world - renowned immunologist who opene...	the szent - gyrgyi prize for progress in cancer research is a prestigious scientific award established by the national foundation for cancer research ( nfcr)a leading cancer research charitable organization in the united states that is committed to supporting innovative cancer research on the global scale that aims to ...
[ [ "we report a case with ruptured cerebral aneurysm arising from pcoma , which originated from the internal carotid artery ( ica ) distal to the origin of achoa .", "the anterior choroidal artery ( achoa ) supplies several important structures including the optic tract , geniculate body , posterior limb of ...	the anterior choroidal artery has several kinds of variations . among them , the transposition of anterior choroidal artery and posterior communicating artery origins has been extremely rare . we report a case with cerebral aneurysm arising from posterior communicating artery which origin was distal to the anterior cho...
[ [ "our metaproteomic analyses revealed that the 1 and 1 symbionts express a surprisingly high number of their transposase proteins , many of which are intact and possibly active , and we hypothesize that abundant transposase expression plays a key role in te expansion .", "based on the high numbers of trans...	abstracttransposases , enzymes that catalyze the movement of mobile genetic elements , are the most abundant genes in nature . while many bacteria encode an abundance of transposases in their genomes , the current paradigm is that the expression of transposase genes is tightly regulated and generally low due to its sev...
[ [ "joubert syndrome ( js ) was initially described in 1968 in 4 siblings with agenesis of the cerebellar vermis presented with episodic hyperpnea , abnormal eye movements , ataxia , and intellectual disability1 ) .", "several years later , a pathognomonic midbrain - hindbrain malformation the molar tooth ...	joubert syndrome ( js ) is characterized by the molar tooth sign ( mts ) with cerebellar vermis agenesis , episodic hyperpnea , abnormal eye movements , and hypotonia . ocular and oculomotor abnormalities have been observed ; however , horner syndrome ( hs ) has not been documented in children with js . we present the...
[ [ "the patient was a 77-year - old female patient admitted for surgery for the chief complaint of an intraductal carcinoma in the left breast that was diagnosed at another hospital .", "the plain chest radiographs taken 3 years earlier showed \" no detection of abnormal findings \" , and dyspnea occurred du...	bronchial anthracosis was recently defined in the english radiology literature as a luminal narrowing associated with anthracotic pigmentation on bronchoscopy without a relevant history of pneumoconiosis or smoking . anthracosis refers to the presence of carbon particles in the lungs , not to a disorder per se . anthra...
[ [ "a patient with severe papulopustular rosacea ( ppr ) and severe background erythema responded well to a treatment regimen consisting of a short course of antibiotics in combination with a corticosteroid , followed by monotherapy with isotretinoin.in patients with very severe , inflamed disease , it is necess...	rosacea is a chronic inflammatory disease that can manifest as a spectrum of symptoms including erythema , inflammatory lesions , edema , and telangiectasia . treatment decisions need to be adapted to reflect the nature and severity of the different symptoms present . in this report , we discuss the case of a female pa...
[ [ "the typical adult individual seen by a primary care physician most likely believes that cancer screening is a good idea , but without comprehending the trade - off of harms to benefit or the uncertainties surrounding their magnitude .", "while professional society screening guidelines generally promote b...	abstractthis article reviews four important screening principles applicable to screening mammography in order to facilitate informed choice . the first principle is that screening may help , hurt , or have no effect . in order to reduce mortality and mastectomy rates , screening must reduce the rate of advanced disease...
[ [ "we demonstrate how this rationally driven , systematic strategy enabled \n the rapid optimization of an unselective artemisinin - hydroxylating \n p450 variant ( figure 1c ) into a set of p450 \n oxidation catalysts with highly refined regio- and stereoselectivity \n for the hydroxylation of each of the thre...	the selective oxyfunctionalization of isolated sp3 c h bonds in complex molecules represents a formidable challenge in organic chemistry . here , we describe a rational , systematic strategy to expedite the development of p450 oxidation catalysts with refined regio- and stereoselectivity for the hydroxylation ...
[ [ "however , according to the literature studied , no research has made the correlation between the findings of the swallowing performance with oral health in elderly patients after stroke", ". therefore , the aim of this study was to relate the condition of oral health to the level of oral intake and the d...	backgroundaccording to the literature , the occurrence of dysphagia is high in cases of stroke , and its severity can be enhanced by loss of teeth and the use of poorly fitting prostheses.objectiveto verify that the status of oral health influences the level of oral intake and the degree of swallowing dysfunction in el...
[ [ "in recent years , video - assisted intubation devices have flooded theaters , and , to a lesser extent , are also being used in icus . but can such new technology really contribute to making tracheal intubation in the icu less life - threatening , or even more life - saving ? noppens and colleagues , in a st...	the c - mac video laryngoscope substantially reduced poor glottic views and increased intubation success in icu patients with at least one predictor for difficult intubation . however , all video - assisted and optical intubation devices have different view angles , thus producing different images with particular disto...
[ [ "pulsed - field gel electrophoresis patterns of 6 listeria monocytogenes serotype 1/2b isolates collected from listeriosis patients in gipuzkoa , northern spain , during january 2013february 2014 .", "the presence of the outbreak strain was confirmed in high amounts ( 5.2 10 cfu / g ) by several other cu...	in the province of gipuzkoa , spain ( 700,000 inhabitants ) , 712 episodes of human listeriosis were recorded annually during 20092012 . however , during january 2013february 2014 , 27 episodes were detected , including 11 pregnancy - associated cases . fifteen cases in 2 epidemiologically unrelated outbreaks were caus...
[ [ "this review of peer - reviewed literature was conducted to evaluate the cumulative state of knowledge related to toothbrush contamination , its possible role in disease transmission , and in preparation for a research study related to toothbrush contamination in critically ill adults .", "toothbrushes ma...	toothbrushes are commonly used in hospital settings and may harbor potentially harmful microorganisms . a peer - reviewed literature review was conducted to evaluate the cumulative state of knowledge related to toothbrush contamination and its possible role in disease transmission . a systematic review was conducted on...
[ [ "this article briefly reviews the need for emergency care in africa and barriers to its integration into health systems in the region .", "we describe an example of an emergency care initiative at muhimbili national hospital ( mnh ) in dar es salaam that has integrated a multi - cadre training program wit...	even though sub - saharan africa faces a disproportionate burden of acute injury and illness , few clinical facilities are configured to take an integrated approach to resuscitation and stabilization . emergency care is a high - impact and cost - effective form of secondary prevention ; disease surveillance at faciliti...
[ [ ". , 2003 ) confirmed the existence of a distinct regulatory t cell ( treg ) population .", "there is growing evidence that cytokines substantially add to the immune regulatory function of treg in vivo .", "together these findings classify camp as a key component of treg suppressive mechanism in vitro...	understanding tolerance mechanisms at the cellular and molecular level holds the promise to establish novel immune intervention therapies in patients with allergy or autoimmunity and to prevent transplant rejection . administration of mab against the cd4 molecule has been found to be exceptionally well suited for inten...
[ [ "herein , we report the results of our cross - sectional analyses of hcv genotype distribution and its association with certain clinical features in patients with chronic hcv infection in khuzestan province conducted from september 2006 to september 2009 . \n", "these observations have led us to determine...	background hepatitis c virus ( hcv ) infection is responsible for considerable morbidity and mortality worldwide . the hcv genotype has a geographic distribution and an important role in clinical and histological outcomes . this study determined hcv genotypes and their related risk factors among patients from khuzes...
[ [ "this was achieved by replacing some of the image details . in this paper , a robust medical image watermarking scheme using fractional wavelets is proposed .", "we conclude the work presenting the future enhancements to obtain more robust medical image watermarking schemes .", "digital image watermar...	exchanging of medical data requires efficient authentication and protection of medical data that can be illegally modified . watermarking plays an important role in protecting , sharing , and securing medical data . in this work , a robust nonblind medical image watermarking scheme is proposed . the process involves tw...
[ [ "septic shock is consistently the most common causative factor identified for acute kidney injury ( aki ) in critical illness , and has been associated with nearly 50% of cases internationally . despite advances in our understanding of the pathophysiology of septic aki ,", "the association between elevate...	in critical illness , septic shock is a contributing factor in nearly half of all cases of acute kidney injury ( aki ) . traditional approaches to prevention of organ dysfunction in early sepsis have focused on prevention of hypoperfusion by optimisation of systemic haemodynamics , primarily by fluid resuscitation . fl...
[ [ "the large through and through periapical pathosis with both buccal and palatal bone loss is managed by periapical surgery adopting a novel method of separation of lesion after nonresponsiveness of the pathosis to intracanal medicament and of the smaller periapical pathosis to long - term intracanal medicam...	conventional nonsurgical endodontic treatment has a high degree of clinical success , but in certain cases surgical intervention becomes necessary . this is the case report of a patient presenting with bilaterally separate periapical lesions in the maxillary anterior region . one lesion was managed by periapical surger...
[ [ "however , there is a lack of information that describes the risk factors and prognostic implications of fu among hd patients in the arab middle east .", "we aim to evaluate this association and its impact on the outcomes over a 5-year period .", "interestingly , a recent study advocated a higher inci...	foot ulceration ( fu ) remains a serious concern for patients worldwide . we analyzed the incidence , risk factors , and outcome of fu in hemodialysis ( hd ) patients . a retrospective cohort study was conducted for 252 hd patients who were followed up for 5 years . patients were categorized according to whether they d...
[ [ "the neuronavigation had proven to be a great device for the surgical treatment of variable neurosurgical problems such as tumor resection or biopsy , the surgery for epilepsy , vascular neurosurgery , the localization of functional and eloquent area , spinal neurosurgery and the operation for hydrocephalus9,...	objectiveneuroendoscopy is applied to various intracranial pathologic conditions . but this technique needs informations for the anatomy , critically . neuronavigation makes the operation more safe , exact and lesser invasive procedures . but classical neuronavigation systems with rigid pinning fixations were difficult...
[ [ "these strains were isolated from 74 cerebrospinal fluid ( csf ) samples and 73 sputum samples from 147 different patients .", "unexpectedly , the results showed that the 7-bp insertion of pks15 that causes a frameshift mutation resulting in an intact pks15/1 was found in most strains of all genotypes , e...	to determine whether intact pks15/1 is unique to the w - beijing family , we investigated 147 mycobacterium tuberculosis strains with different is6110 genotypes . intact pks15/1 was found in 87.8% of cerebrospinal fluid and 84.9% of sputum isolates . it was found not only in w - beijing strains ( 97% ) but also in othe...
[ [ "oligodendroglioma cells are detectablein the cerebrospinal fluid in up to 14% of patients , and we recently treated a case of multiple anaplastic oligodendrogliomas , describe the case in detail and discuss the distinction between multicentric and dissemination via cerebrospinal pathways and the treatmen...	a 72 year - old male hospitalized with aphasia , abnormal behavior , and rapidlyprogressive dementia.magnetic resonance imaging ( mri ) enhanced by contrast media demonstrated multiplebrain tumors in left parietal lobe and left paraventricular region . biopsy was performed , andhistopathological examination and genetic...
[ [ "a study showed that the improvement of ir , following diet and/or surgery - induced weight loss , was associated with the magnitude of decrease in serum pedf levels and pedf expression of adipose tissue . in this context , the present study was undertaken to get insights into the effect of metformin on the e...	objective . pigment epithelium - derived factor ( pedf ) plays an important role in obesity - induced insulin resistance ( ir ) . the study aims to investigate the effect of metformin , a widely used agent to improve ir , on pedf production both in vivo and in vitro . methods . sd rats were divided into normal control ...
[ [ "the detected molecular species were subsequently analyzed for protein and glycan composition and compared to established psa forms .", "circulating psa - igm complexes separated by gel filtration from subjects with bph and pca were subjected to on - chip immunoaffinity profiling using monoclonal anti - p...	this study was aimed at defining molecular species of prostate - specific antigen ( psa ) in immune complexes with immunoglobulin m ( igm ) . having in mind the oligoreactivity of igm and its preference for carbohydrate antigens , there is the possibility that it can selectively recognize known psa glycoisoforms . psa ...
[ [ "however , self - report fails to identify undiagnosed diabetes and tends to underestimate diabetes prevalence and incidence in our study group ( 9 ) . at baseline , whi participants", "a total of 161,808 women ( 68,132 in clinical trials and 93,676 in an observational study ) were enrolled in the whi bet...	objectiveto examine determinants of racial / ethnic differences in diabetes incidence among postmenopausal women participating in the women s health initiative.research design and methodsdata on race / ethnicity , baseline diabetes prevalence , and incident diabetes were obtained from 158,833 women recruited from 19931...
[ [ "cholelithiasis presented as chronic right back pain in the case discussed in this report . according to the clinical practice guidelines , gallbladder lithiasis is a common condition . around two - thirds of the cases", "are asymptomatic , with the most frequent clinical presentation being the presence o...	chronic right back pain is a symptom in both biliary lithiasis and chronic cholecystitis . ten percent of the population in the world suffers from biliary lithiasis . only 20% are symptomatic . the first diagnostic test of choice is an abdominal ultrasound . when a suggestive clinical sign of biliary colic with negativ...
[ [ "the process of odontogenesis is under the control of homeobox ( hox ) genes ; a number of different mesenchymal regulatory molecules and their receptors .", "pax9 is a transcription factor required for tooth morphogenesis and plays a role in the establishment of the inductive capacity of the tooth mesenc...	the interruption of odontogenesis by any etiological factor may result in dental anomalies . apart from the environmental factors , the impact of genetics in dental anomalies was found to be a factor in different levels . many authors had questioned a common genetic defect resulting in different phenotypic conditions s...
[ [ "it is however possible that some empirical knowledge is successfully used in homeopathy unrelated to its axioms like can be cured with like , less is more or the memory of water .", "homeopathy claims a curative reaction from a small dose of a drug of which high doses cause symptoms similar to tho...	homeopathy claims a curative reaction from small doses of a substance , high doses of which cause symptoms similar to those the patient is suffering from . hormesis is a concept of biphasic dose - response to different pharmacological and toxicological agents . according to this concept , a small dose of a noxious agen...
[ [ "although several reports of tart sonographic features have been described previously , the reports are limited by a small numbers of cases or the old age of the patients .", "testicular adrenal rest tumors ( tarts ) are benign intratesticular masses that occur in male patients with congenital adrenal hyp...	abstractthe aim of this study was to evaluate the imaging features of testicular adrenal rest tumors ( tarts ) on baseline ultrasound ( bus).the imaging features of 30 tart lesions pathologically or clinically confirmed in 15 patients who had undergone bus were evaluated , and the sonographic characteristics of the les...
[ [ ", however , zimmerman and colleagues demonstrated that the predictors of bone density in nursing home patients were the same as for those living in the community , namely , age , gender , race , and weight . ", "we have compared hip fracture rate in long - term care ( ltc ) and community - dwelling men ...	introduction . this study compares hip fracture rates in long term care ( ltc ) residents with those in the community to determine if their high rate of fracturing reflects the extreme age and predominantly female nature of that population . methods . hospital discharge data in london ontario ( population 350,000 ) and...
[ [ "we investigated the angiogenic response induced by gelatin sponges soaked with the cell suspensions and implantedonthecamsurfacefrom8today12ofincu - bation and we studied the effects of mmec and mgusec on the expression of endogenous levels in the cam of vegf , fgf-2 , angiopoietin-1(ang-1 ) , hypoxia - indu...	abstractwe have attempted a fine characterization of the angiogenic response induced by multiple myeloma endothelial cells ( mmec ) by using the chick embryo chorioallantoic membrane ( cam ) assay and by reverse transcriptase - polymerase chain reaction ( rt - pcr ) . results showed that in the cam assay mmec induced a...
[ [ "preeclampsia , a pregnancy - complicated syndrome , is one of the leading causes of maternal and fetal morbidity and mortality .", "risk factors involved in preeclampsia have been increasingly identified ( table 1 ) , and emergence of any risk factor may cause a woman to develop preeclampsia . however , ...	preeclampsia , a relatively common pregnancy disorder , is one of the major causes of maternal and fetal morbidity and mortality . despite numerous research , the etiology of this syndrome remains not well understood as the pathogenesis of preeclampsia is complex , involving interaction between genetic , immunologic , ...
[ [ "spending hours in plastic surgery opd in a government medical college and dealing with the kind of queries posed to us by patients and often having to see delayed and neglected patients made us question and wonder on various views that people have of plastic surgery .", "most of the patients had no idea ...	the field of plastic surgery , while being famous for aesthetic surgery , also includes craniofacial surgery , hand surgery , burn surgery , microsurgery , reconstructive plastic surgery and paediatric plastic surgery . the magnanimous progress in these areas , though a hot topic in conferences , remains cryptic to the...
[ [ "this mixed - methods study ( yin , 2003 ) seeks to more accurately identify perceptions of acceptance for various age- , race- , and sexual identity - based segments of the population within the gay and mainstream communities at a pivotal time in the evolution of both urban gay communities and mainstream soc...	changes in gay and bisexual men s connectedness to the gay community are related to the declining public visibility of hiv / aids and greater acceptance for homosexuality and bisexuality in mainstream society . little work , however , has focused on perceived acceptance for subgroups within the gay community or broader...
[ [ "thus , the aim of this paper is to both describe and discuss the animal models used for the study of ms .", "studies on animal models can be relevant as they mimic the aspects of the human disease as the development and maintenance of ms characteristics , particularly obesity , type 2 diabetes , dyslipid...	metabolic syndrome has been defined as a group of risk factors that directly contribute to the development of cardiovascular disease and/or type 2 diabetes . insulin resistance seems to have a fundamental role in the genesis of this syndrome . over the past years to the present day , basic and translational research ha...
[ [ "the goal of this prospective study was to determine the effects of adt on body composition and resting metabolic rate in patients with metastatic pca .", "decreases with age , physical inactivity , sympathetic nervous system and endocrine status.7,8 to our knowledge , the effects of adt on ree have not b...	introductiontestosterone is needed for normal male development , muscle strength , bone mineralization , hematopoietic function , and sexual and reproductive functions . the main purpose of androgen deprivation therapy in prostate cancer is to reduce tumor progression , but therapy is often accompanied by significant a...
[ [ "hela is a human cervical cancer cell line ; nih/3t3s is a mouse embryonic fibroblast line ; hepg3 is from hepatocellular carcinoma ; raw264.7 is a mouse leukemic monocyte macrophage cell line .", "resulting nanoparticles are separated from the solution by addition of ethanol and ethyl acetate followed by...	one way to image the molecular pathology in alzheimer s disease ( ad ) is by positron emission tomography using probes that target amyloid fibrils . however , these fibrils are not closely linked to the development of the disease . it is now thought that early stage biomarkers that instigate memory loss comprise of a o...
[ [ "the reduction of the intraocular pressure ( iop ) represents an additional advantage of clonidine because it makes the eye surgery easier and reduces the frequency of complications , such as expulsion of the vitreous humor when the lens posterior capsule is broken during phacoemulsification .", "this led...	objectives . the aim of this study was to assess the effects of clonidine on intraoperative analgesia , sedation , intraocular and blood pressure , arrhythmia , and ischemia . methods . forty patients undergoing cataract surgery were allocated into two groups . they were monitored with holter machine , the pupil was ...
[ [ "hypertension , a notable sequela of obesity , was already common in sub - saharan africa but has been reported to be worsening in prevalence in recent years .", "rates of obesity for younger schoolchildren in east africa remain unclear , though obesity at younger ages may carry greater importance becau...	cardiovascular disease ( cvd ) frequently has roots in childhood , including following childhood - onset hypertension . incidence of cvd has increased in developing countries in east africa during recent urbanization . effects of these shifts on childhood hypertension are unclear . our objectives were to ( 1 ) determin...
[ [ "herein , we analyze the existing literature on lvhr , in an effort to examine the optimal surgical technique , complications , and long - term results in comparison with the open ventral hernia repair ( ovhr ) .", "incisional hernia is a common long - term complication of abdominal surgery and is estimat...	background : the purpose of this study was to analyse the surgical techniques , perioperative complications , and recurrence rate of laparocopic ventral hernia repair ( lvhr ) , in comparison with the open ventral hernia repair ( ovhr ) , based on the international literature.methods:a medline search of the english lit...
[ [ "we report a case of serious neurotoxicity following 5-fu infusion for malignant gastrointestinal stromal tumor ( gist ) and also briefly review 5-fu related neurotoxicity .", "neurotoxicites of 5-fu with manifestations of somnolence , upper motor neuronal signs , cerebellar ataxia and a cluster of sympto...	5-fluorouracil ( 5-fu ) is a commonly used chemotherapeutic agent . however , its neurotoxicity is rare and not well recognized . we report a case of 5-fu neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year - old male patient having malignant gastrointestinal stromal...
[ [ "these observations prompted us now to assess the association between celiac disease and severe chronic depression and schizophrenia .", "greater awareness of its varying presentation and the availability of new serologic tests have shown celiac disease to be relatively common ( 10 ) .", "celiac disea...	aimthe aim of this study was to determine the prevalence of celiac disease in iranian patients suffering from chronic depression or schizophrenia.backgroundpsychiatric disorders are common in untreated celiac disease.patients and methodstwo hundred iranian inpatient men with in chronic phase of depressive disorders or ...
[ [ "comparison of confirmed cases of dengue fever and of symptomatic malaria in patients examined at the emergency department of cayenne hospital , cayenne , french guiana , january 2004march 2006 .", "concurrent dengue ( edc and ldc ) and malaria were confirmed in 17 of the 1,723 patients ( 1% ) , corr...	dengue malaria co - infection reports are scarce . of 1,723 consecutive febrile patients in cayenne hospital , 238 had dengue ( 174 early dengue fever cases ) and 393 had malaria ( 371 acute malaria ) ; 17 had both . diagnosis of 1 of these 2 infections should not rule out testing for the other infection .
[ [ "to date , kaposi sarcoma has not been mentioned among the adverse effects of triptolide / tripdiolide , ethyl acetate extracts or polyglycosides of the chinese herbal remedy tripterygium wilfordii hook f." ], [ "she underwent treatment with corticosteroids , methotrexate and gold sodium thiosulfate ,...	summarybackgroundto date , kaposi sarcoma has not been mentioned among the adverse effects of triptolide / tripdiolide , ethyl acetate extracts or polyglycosides of the chinese herbal remedy tripterygium wilfordii hook f.case reporta patient was diagnosed with rheumatoid arthritis at the age of 29 years . she underwent...
[ [ "on the other hand , the researcher , despite searching thoroughly , did not find any studies on family - focused supportive care in heart failure patients in iran . therefore , the present study aimed to define the effect of family supportive intervention on heart failure self - care behaviors .", "nurse...	background : heart failure is one of the chronic heart diseases and a debilitating condition of increased prevalence in the elderly . one of the important and non - pharmacological strategies for improving clinical outcomes in these patients is promotion of the self - care . background and social environment in which a...
[ [ "this paper aims to analyze whether innovations introduced by veneto regional law 7/2007 have modified immunization coverage rates and parents participation in vaccination acceptance .", "all italian national vaccine plans ( nvp ) , from 2005 to present , notice the opportunity to begin a cultural and soc...	summarythe burden of infectious diseases preventable by vaccination decreased considerably over last decades in all countries provided with effective immunization schedules . implementation of these programs with new vaccines has started discussion on duality between mandatory and recommended vaccinations . regional au...
[ [ "therefore , this study performed to assess personnel blood pressure and its risk factors in one of the medical universities of tehran in te health day of 2013 . \n", "the first step of planning and policy making for intervention and modification of cardiovascular diseases in a defined population is to as...	background hypertension is a risk factor for life threatening diseases such as cerebrovascular accidents , coronary artery diseases , congestive heart failure and chronic renal failure . the prevalence of non - communicable diseases such as hypertension and diabetes including obesity has increased over the past few yea...
[ [ "hlgdb provides a user - friendly interface through which information can be easily retrieved , including the union and intersection of different gene lists , searches for mirna predictions and visualization on the gene transcript sequence of the mirna target predictions .", "hlgdb aims to providing a use...	lysosomes are cytoplasmic organelles present in almost all eukaryotic cells , which play a fundamental role in key aspects of cellular homeostasis such as membrane repair , autophagy , endocitosis and protein metabolism . the characterization of the genes and enzymes constituting the lysosome represents a central issue...
[ [ "the authors report a very rare case of spinal cord and brain metastasis of mpnst in the lumbar spine that occurred in a 18-year - old man without nf .", "a malignant peripheral nerve sheath tumor ( mpnst ) is a sarcoma that arises from peripheral nerves or cells of the associated nerve sheath ( schwann c...	a malignant peripheral nerve sheath tumor ( mpnst ) is a type of sarcoma that arises from peripheral nerves or cells of the associated nerve sheath . this tumor most commonly metastasizes to the lung and metastases to the spinal cord and brain are very rare . we describe a case of young patient with spinal cord and bra...

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