messages listlengths 2 2 | source stringclasses 2
values | protein_id stringlengths 6 11 ⌀ |
|---|---|---|
[
{
"role": "user",
"content": "Retbindin\nWhat is the long-term effect of the absence of the riboflavin-binding protein on the retina?"
},
{
"role": "assistant",
"content": "The long-term effect of the absence of the riboflavin-binding protein on the retina is retinal degeneration."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "E3 ubiquitin-protein ligase Mdm2\nDoes this protein have any regulatory functions in the cell?"
},
{
"role": "assistant",
"content": "Yes, this protein has regulatory functions in the cell, including the regulation of cell cycle progression and apoptosis."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Bcl-2-related protein A1\nWhat happens to neutrophils when this protein is knocked down?"
},
{
"role": "assistant",
"content": "Knocking down this protein impairs the maintenance of neutrophil progenitors."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Glucosylceramidase\nWhat type of cells are affected by changes in the level of this enzyme?"
},
{
"role": "assistant",
"content": "Dopaminergic cells may be affected by changes in the level of this enzyme."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Activin receptor type-1\nCan a mutation in this protein cause malformation of normal skeletal elements?"
},
{
"role": "assistant",
"content": "Yes, patients with diseases associated with mutations in this protein can variably show malformation of normal skeletal ele... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Transient receptor potential cation channel subfamily M member 5\nCan the function of this protein be modulated by genetic variants?"
},
{
"role": "assistant",
"content": "Yes, as shown in the luciferase and electrophoretic mobility shift assays"
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Vesicle-associated membrane protein 7\nWhat is the impact of the protein's function on airway hyperresponsiveness?"
},
{
"role": "assistant",
"content": "The protein"
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Uteroglobin\nIs the protein's effect on cells dependent on its overexpression or endogenous expression?"
},
{
"role": "assistant",
"content": "Both forms of expression have been observed to have an anti-inflammatory effect."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Pancreatic triacylglycerol lipase\nWhat type of biochemical process is this protein likely involved in?"
},
{
"role": "assistant",
"content": "This protein is likely involved in a process known as lipid digestion, where triglycerides are broken down into smaller com... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "7-dehydrocholesterol reductase\nCan the protein be inhibited to potentially improve outcomes?"
},
{
"role": "assistant",
"content": "Yes, inhibiting this protein using AY9944 completely rescued zebrafish from lipopolysaccharide death."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Latent-transforming growth factor beta-binding protein 4\nIs the protein found in control dogs?"
},
{
"role": "assistant",
"content": "Yes, the protein is found in control dogs."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Fibroblast growth factor 19\nWhat is the type of the protein based on its function?"
},
{
"role": "assistant",
"content": "The protein is a type of growth factor."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Sphingosine-1-phosphate lyase 1\nWhat is the primary function of this protein in fat metabolism?"
},
{
"role": "assistant",
"content": "This protein may be a key regulator of fat metabolism."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "TP53-regulated inhibitor of apoptosis 1\nHow does the expression of the protein relate to the presence of TP53?"
},
{
"role": "assistant",
"content": "The expression of the protein is induced by the binding of TP53, indicating a regulatory relationship between the t... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "L-selectin\nWhat type of groups were compared to identify this protein as a biomarker?"
},
{
"role": "assistant",
"content": "The study compared a healthy control group, a group with single episode MDD, a group with recurrent MDD, and a group with more than two epis... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "CD5 antigen-like\nWhat is the role of the protein in medical research and diagnosis?"
},
{
"role": "assistant",
"content": "The protein is used in medical research and diagnosis to predict kidney disease in individuals with diabetes."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Transmembrane protein 33\nWhere is Transmembrane protein 33 located within a cell?"
},
{
"role": "assistant",
"content": "It is located in the endoplasmic reticulum."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Betaine--homocysteine S-methyltransferase 1\nHow was the protein identified in the study?"
},
{
"role": "assistant",
"content": "It was identified through co-immunoprecipitation, 2-dimensional electrophoresis, and mass spectrometry detection."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Axin-2\nIs this protein related to cell proliferation?"
},
{
"role": "assistant",
"content": "Yes, it is a target gene that can be involved in cell proliferation processes, as it is associated with the Wnt signaling pathway."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Diacylglycerol kinase iota\nCan the absence of the protein affect the way sensory neurons respond to stimuli?"
},
{
"role": "assistant",
"content": "Yes, the absence of the protein can affect the way sensory neurons respond to certain stimuli, leading to enhanced ca... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "C-C chemokine receptor type 7\nHow does the protein respond to different ligands in terms of desensitisation phase?"
},
{
"role": "assistant",
"content": "It induces distinct impedance profiles with an apparent bias during the desensitisation phase of the response."... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Junction-mediating and -regulatory protein\nWhat is the relationship between this protein and Bax expression?"
},
{
"role": "assistant",
"content": "With GC treatment, overexpression of this protein could significantly increase the expression of Bax, while knockdown... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Myelin transcription factor 1\nWhat is the expression pattern of the protein in xenograft tissues?"
},
{
"role": "assistant",
"content": "The expression of the protein is increased in xenograft tissues."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "3-mercaptopyruvate sulfurtransferase\nWhat does this protein provide to the cell?"
},
{
"role": "assistant",
"content": "This protein provides robust antioxidant defenses."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "SEC7 domain-containing protein\nWhat is the role of this protein in the malaria parasite Plasmodium falciparum?"
},
{
"role": "assistant",
"content": "It is presumably involved in the regulation of the parasite"
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Neurexin-3\nDoes the protein work with other types of neurons to regulate pain signals?"
},
{
"role": "assistant",
"content": "The protein interacts with GABAergic cells and excitatory or dynorphin positive neurons to regulate pain signals."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Transmembrane protease serine 4\nDoes the presence of this protein in PDAC patients have any impact on their prognosis?"
},
{
"role": "assistant",
"content": "Yes, it is associated with a poor prognosis of PDAC patients."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Myeloid-derived growth factor\nWhat is the protein's role in regulating neutrophils in response to damage?"
},
{
"role": "assistant",
"content": "It regulates their behavior."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "SAM pointed domain-containing Ets transcription factor\nIs this protein involved in the regulation of airway mechanics?"
},
{
"role": "assistant",
"content": "Yes, the loss of club cell CREB prevents IL-1B-mediated impairments in airway mechanics, suggesting a role ... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Histidine ammonia-lyase\nHow does this protein help in adaptation to adverse environmental conditions?"
},
{
"role": "assistant",
"content": "This protein helps in the production and accumulation of metabolites for adaptation to adverse terrestrial environmental con... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Calpain-3\nWhat is the effect of loss-of-function mutations in the gene that codes for this protein?"
},
{
"role": "assistant",
"content": "It causes a dystrophy of the limb-girdle muscles."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Zinc finger protein 609\nCan the protein's influence be alleviated by adding a specific microRNA?"
},
{
"role": "assistant",
"content": "Yes, the protein's influence can be partly alleviated by the addition of anti-miR-501-3p."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Uroporphyrinogen-III synthase\nWas there a specific causal effect model used in the MR analysis?"
},
{
"role": "assistant",
"content": "Yes, the random-effect inverse-variance-weighted (IVW) method was used."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "P2Y purinoceptor 1\nWhat effect does the presence of an electrical field have on the expression of the protein?"
},
{
"role": "assistant",
"content": "The electrical field up-regulates the protein."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "DNA (cytosine-5)-methyltransferase 3B\nIs the CT genotype associated with a lower risk of breast cancer?"
},
{
"role": "assistant",
"content": "Yes, in comparison to the homozygous CC genotype, it has a significantly lower risk."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "E3 ubiquitin-protein ligase SMURF2\nWhat type of ubiquitin chain is involved in the modification of MOR1?"
},
{
"role": "assistant",
"content": "MOR1 is modified by a Lys48-linked polyubiquitin chain."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Fibroblast growth factor 8\nIs the protein's mRNA expression affected at different developmental stages?"
},
{
"role": "assistant",
"content": "Yes, it is downregulated at different stages."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Dual specificity protein phosphatase 1\nHow does the overexpression of miR-101 affect the activity of this protein?"
},
{
"role": "assistant",
"content": "The overexpression of miR-101 decreases the activity of this protein."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Zinc finger protein 408\nAre all detected variants pathogenic?"
},
{
"role": "assistant",
"content": "It is suspected that most detected variants are pathogenic."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Somatostatin receptor type 1\nCan hypermethylation of the protein be used as a biomarker for disease?"
},
{
"role": "assistant",
"content": "Yes, hypermethylation of the protein showed highly discriminating receiver operator characteristic curve profiles, which clea... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Ubiquitin-protein ligase E3C\nWhat is the effect of knocking down the protein's expression on cell behavior?"
},
{
"role": "assistant",
"content": "Knocking down the protein's expression inhibits cell proliferation, migration, and invasion."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Peptidyl-prolyl cis-trans isomerase FKBP5\nDoes the presence of hormone affect the interaction between this protein and estrogen receptors?"
},
{
"role": "assistant",
"content": "The interaction between this protein and ERα was not changed by 17β-estradiol (E2) trea... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Protein 4.1\nWhat is the potential impact of altering the protein's activity?"
},
{
"role": "assistant",
"content": "Altering its activity may affect the sensitivity of gastric cancer cells to cisplatin."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Oxysterol-binding protein-related protein 2\nHow does this protein control the trafficking of late endosomes?"
},
{
"role": "assistant",
"content": "This protein increases PI(4,5)P2 in late endosomes in a FAK-dependent manner, controlling their tubulovesicular traff... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Gamma-synuclein\nAre the functionalities of synuclein proteins highly diversified?"
},
{
"role": "assistant",
"content": "Yes, their interactors are involved in a broad spectrum of highly diversified functional pathways."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Catenin delta-1\nDoes the protein play a role in apoptosis?"
},
{
"role": "assistant",
"content": "Yes, the protein is involved in apoptosis."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "DNA helicase\nDoes this protein have a role in cancer cell behavior?"
},
{
"role": "assistant",
"content": "Yes, it facilitates the proliferation, migration, invasion, and EMT of cancer cells."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Neuroendocrine secretory protein 55\nHow do mice without this protein behave?"
},
{
"role": "assistant",
"content": "Mice without this protein show abnormal reactivity to novel environments, independent of general locomotor activity and anxiety."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "C-terminal-binding protein 1\nIs the protein's role in PCOS patients related to its function in MetS-associated diseases?"
},
{
"role": "assistant",
"content": "Yes, the protein"
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Organic anion transporter 3\nCan proteasome inhibition be used to restore the impairment of this protein under pathological conditions?"
},
{
"role": "assistant",
"content": "Yes, it can be used."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Uteroglobin\nWhat is the potential role of this protein as a biomarker?"
},
{
"role": "assistant",
"content": "This protein is a potential early biomarker for a chronic inflammatory condition in type 2 diabetes."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Legumain\nWhat kind of health issue is the protein associated with?"
},
{
"role": "assistant",
"content": "Cardiovascular diseases."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "C-terminal-binding protein 1\nWhat is the role of the protein in adipogenic differentiation and function?"
},
{
"role": "assistant",
"content": "The protein plays a key role in the inhibitory effect of Ang II on adipogenesis."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Osteocalcin\nWhat is the general function of the protein?"
},
{
"role": "assistant",
"content": "The protein is associated with bone health, specifically involved in bone mineralization and density."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Spartin\nWhat is the overall effect of the protein on the cell?"
},
{
"role": "assistant",
"content": "It is beneficial and plays a vital role in cell protection during aging."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Muscarinic acetylcholine receptor M1\nWhat is one of the techniques that can be used to study this protein?"
},
{
"role": "assistant",
"content": "Photoaffinity labeling."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Myelin-associated oligodendrocyte basic protein\nAre there any known associations between the levels of the protein and cognitive functions?"
},
{
"role": "assistant",
"content": "Yes, lower amounts of the protein are associated with cognitive dysfunction."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Adiponectin\nIs the protein associated with a lower risk of certain cardiovascular diseases?"
},
{
"role": "assistant",
"content": "Yes, its levels are lower in patients with increased risk of heart diseases."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Interferon regulatory factor 6\nCan a mutation in this gene cause abnormalities in the oral cavity and digits?"
},
{
"role": "assistant",
"content": "Yes, a mutation in this gene can cause abnormalities in the oral cavity and digits."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Protein SLX4IP\nHow is the protein related to metastatic progression?"
},
{
"role": "assistant",
"content": "The protein is an essential driver of metastatic progression."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Myelin transcription factor 1\nHow does this protein contribute to cell proliferation?"
},
{
"role": "assistant",
"content": "The enforced expression of miR-141 attenuated its expression and suppressed cell proliferation."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Doublesex- and mab-3-related transcription factor 1\nWhat is the primary role of this protein in birds?"
},
{
"role": "assistant",
"content": "The primary role of this protein in birds is sex determination, and it is essential for testis development."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Carbohydrate sulfotransferase 14\nWhat type of complications can occur if the protein's function is impaired?"
},
{
"role": "assistant",
"content": "Complications such as thoracic kyphosis, hypotonia, and myopathy can occur if the protein's function is impaired."
... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Mitochondrial glycine transporter\nWhat is the primary function of this protein in the mitochondria?"
},
{
"role": "assistant",
"content": "This protein is required for haem biosynthesis and also doubles as an isopentenyl pyrophosphate (IPP) transporter."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Adhesion G protein-coupled receptor B1\nIs this protein typically found on the surface of cells?"
},
{
"role": "assistant",
"content": "Yes, this protein is associated with the gastric epithelial cell membrane."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Adhesion G protein-coupled receptor L3\nWhat are some common symptoms associated with the protein's genetic mutations?"
},
{
"role": "assistant",
"content": "Autism spectrum disorder, attention deficit/hyperactivity disorder, aggressive behavior, mood instability, s... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Sestrin-3\nWhat type of enzyme is the protein?"
},
{
"role": "assistant",
"content": "The protein is an antioxidant enzyme."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Hemojuvelin\nWhat is the effect of mutations in the protein on the body?"
},
{
"role": "assistant",
"content": "Mutations in the protein can lead to iron overload, damage in multiple organs, and a range of clinical symptoms, including liver fibrosis, diabetes, and s... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Laminin subunit beta-1\nWhat is the general function of this protein?"
},
{
"role": "assistant",
"content": "This protein is involved in cell adhesion and is a component of the extracellular matrix."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "RNA ligase 1\nWhat is the effect of using a high concentration of polyethylene glycol (PEG) in the reaction?"
},
{
"role": "assistant",
"content": "It helps the protein to perform its function."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "NPC intracellular cholesterol transporter 1\nIs this protein involved in any human diseases?"
},
{
"role": "assistant",
"content": "This protein is associated with Niemann-Pick disease type C."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "PH domain-containing protein\nWhat triggers the cleavage of the protein?"
},
{
"role": "assistant",
"content": "Sel-dependent palmitoylation of the protein leads to cleavage by calpain-2."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "G-protein coupled receptor 143\nCan the protein be modulated by other substances?"
},
{
"role": "assistant",
"content": "Yes, a certain antagonist, pimozide, also modulates the protein activity."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Betaine--homocysteine S-methyltransferase 1\nIs this protein found in the mitochondria?"
},
{
"role": "assistant",
"content": "Yes, it is found in the mitochondria."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Zinc finger protein 419\nIs the expression of this protein different between tumor and normal samples?"
},
{
"role": "assistant",
"content": "Yes, it was found to be differentially expressed between tumor and normal samples."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Dual specificity tyrosine-phosphorylation-regulated kinase 2\nIn some cancers, does amplification of the gene that encodes this protein occur?"
},
{
"role": "assistant",
"content": "Yes, amplification of the gene occurs in esophageal/lung adenocarcinoma."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Four and a half LIM domains protein 2\nIs this protein involved in any glucose-related cellular responses?"
},
{
"role": "assistant",
"content": "Yes, it is involved in a response to glucose sensing."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Myoblast determination protein 1\nWhat effect does overexpressing Dusp13 in muscle stem cells have on muscle differentiation?"
},
{
"role": "assistant",
"content": "It causes premature muscle differentiation."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Transcription elongation factor SPT6\nWhat is the primary function of this protein?"
},
{
"role": "assistant",
"content": "It acts as a histone chaperone, promoting the reassembly of nucleosomes following the passage of RNA polymerase II."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Caspase-6\nIs the protein involved in enhancing cellular activities?"
},
{
"role": "assistant",
"content": "No, the protein is involved in reducing cellular activities."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Lysine-specific demethylase 2A\nDoes the protein play a role in the pathogenesis of cancer?"
},
{
"role": "assistant",
"content": "Yes, the protein has a vital role in the pathogenesis of clear cell renal cell carcinoma."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Peptidyl-prolyl cis-trans isomerase FKBP5\nIs this protein associated with transcriptionally active or inactive chromatin?"
},
{
"role": "assistant",
"content": "Significant portions of this protein were associated with both transcriptionally active and inactive chr... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Myeloid-derived growth factor\nCan this protein help in restoring the function of damaged tissues?"
},
{
"role": "assistant",
"content": "Yes, it has tissue-functional restorative abilities."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Cerebellin-1\nWhat happens when the protein is downregulated in inflammatory and neuropathic pain models?"
},
{
"role": "assistant",
"content": "The protein is downregulated, and AMPA receptor is upregulated."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Transmembrane protein 132A\nWhat are the underlying causes of developmental defects in multiple caudal structures?"
},
{
"role": "assistant",
"content": "Hindgut malformation is the underlying cause."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Sterol O-acyltransferase 1\nWhat is the role of this protein in cholesterol metabolism?"
},
{
"role": "assistant",
"content": "It is a key enzyme in cholesterol metabolism, driving cholesterol ester (CE) accumulation."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Ubiquitin carboxyl-terminal hydrolase\nCan this protein be inhibited or targeted in order to achieve a specific effect?"
},
{
"role": "assistant",
"content": "Yes, there is a known inhibitor called TCID that can reduce its deubiquitinase activity and has therapeutic... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Muscarinic acetylcholine receptor M1\nWhat type of molecules bind to this protein?"
},
{
"role": "assistant",
"content": "Agonists and antagonists"
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Hypoxia-inducible factor 1-alpha inhibitor\nWhat type of cells might be affected by the protein's inhibition?"
},
{
"role": "assistant",
"content": "Glioblastoma cells."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Myelin-associated glycoprotein\nHow does the concentration of this protein change in the cerebrospinal fluid of individuals with relapsing disease compared to control individuals?"
},
{
"role": "assistant",
"content": "The concentration of this protein is reduced in... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Endoglin\nIs there a correlation between the total exosomal protein and the protein levels?"
},
{
"role": "assistant",
"content": "In HHT patients, a negative correlation between the total exosomal protein and the protein levels was found."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Actin-related protein 2\nIs this protein involved in the formation of synapses between neurons?"
},
{
"role": "assistant",
"content": "Yes, it plays a role in regulating the formation of synapses."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Glutamyl aminopeptidase\nHow is this protein related to M2 macrophage infiltration and activation?"
},
{
"role": "assistant",
"content": "This protein is reliably associated with M2 macrophage infiltration and activation."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Integrin alpha-9\nWhat is the type of receptor that the protein belongs to?"
},
{
"role": "assistant",
"content": "It is a membrane receptor."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Calcineurin subunit B type 1\nIs this protein associated with the structure of the DG area of the brain?"
},
{
"role": "assistant",
"content": "This protein is associated with the structure of the DG area of the brain."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Matrix metalloproteinase-21\nHow is the protein involved in establishing left-right asymmetry in vertebrate embryos?"
},
{
"role": "assistant",
"content": "The protein is involved in establishing left-right asymmetry through the regulation of morphogenetic signals."... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Stromelysin-1\nWhat is the primary function of the protein?"
},
{
"role": "assistant",
"content": "It is possibly responsible for structural destruction and apoptosis of follicular cells."
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Opalin\nWhat type of conditions does the protein's expression increase in?"
},
{
"role": "assistant",
"content": "Inflammatory conditions"
}
] | Protein2Text-QA | null |
[
{
"role": "user",
"content": "inositol-phosphate phosphatase\nWhat are the specific soluble inositol phosphates that are depleted by this protein?"
},
{
"role": "assistant",
"content": "Inositol 1,3,4,5,6-pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) are depleted by this protei... | Protein2Text-QA | null |
[
{
"role": "user",
"content": "Cytosol aminopeptidase\nWhat is the relationship between the protein activity and cell activation as measured by DNA synthesis rate?"
},
{
"role": "assistant",
"content": "Their dose-response curves are similar."
}
] | Protein2Text-QA | null |
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