pubid int32 1.41M 27.9M | instruction stringlengths 202 533 | input stringlengths 66 4.17k | output stringlengths 33 958 |
|---|---|---|---|
11,174,726 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does lung volume reduction surgery restore the normal diaphragmatic length-tension relationsh... | Improved respiratory muscle function is a major effect of a lung volume reduction surgery. We studied length adaptation in rat diaphragmatic muscle in an attempt to elucidate the mechanism by which diaphragmatic function improves after this controversial operation.
We developed a model of elastase-induced emphysema an... | I'd call it Yes. In this experimental model of emphysema and lung volume reduction surgery, emphysema shortens the length at which maximal twitch force is generated and shifts the diaphragmatic length-tension curve to lower lengths; volume reduction returns the length at which maximal twitch force is generated toward n... |
26,707,994 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Are methylation patterns of Vegfb promoter associated with gene and protein expression levels... | We have investigated the epigenetic regulation by dietary fatty acids of Vegfb levels in rats' white adipose tissue and 3T3-L1 cells.
A group of rats were assigned to three diets, each one with a different composition of saturated, monounsaturated and polyunsaturated fatty acids. Samples of white adipose tissues were ... | I'd call it Yes. According to our results, the regulation of Vegfb gene expression by dietary fatty acids may be mediated, at least in part, by epigenetic modifications on Vegfb promoter methylation. Considering the deep association between angiogenesis and tissue growth, we suggest the nutriepigenetic regulation of Ve... |
18,660,423 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does curcumin modulate SDF-1alpha/CXCR4-induced migration of human retinal endothelial cells ( HRECs )? | The stromal-derived factor (SDF)-1alpha and the CXC receptor (CXCR)-4 jointly regulate the trafficking of various cell types and play a pivotal role in cell migration, proliferation, and survival. The purpose of this study was to assess whether curcumin inhibits human retinal endothelial cell (HREC) migration by interf... | This study indicates that curcumin has an inhibitory effect on SDF-1alpha-induced HREC migration. The plausible mechanism of action could be upstream blockage of Ca(2+) influx and the downstream reduction of PI3-K/AKT signals.
So overall I'd say Yes. |
27,448,782 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does microwave coagulation/ablation in combination with sorafenib suppress the overgrowth of ... | Our study is to evaluate the effect of thermal ablation on residual VX2 tumor tissue and the efficiency of sorafenib as an adjuvant therapy after insufficient microwave coagulation (MWC) on a rabbit VX2 liver tumor model.
Thirty-seven rabbits with orthotic VX2 liver tumors were randomly divided into MWC group (n=11), ... | I'd call it Yes. Insufficient thermal ablation promotes residual tumor progression. While the adjuvant therapy of sorafenib serves as an effective way to suppress the overgrowth and neovascularization of residual tumor after insufficient thermal ablation. |
9,699,177 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does the L-arginine-nitric oxide system regulate platelet aggregation in pregnancy? | To investigate the ex vivo platelet aggregation in response to a substrate (L-arginine [L-Arg]) and a donor (sodium nitroprusside [SN]) of nitric oxide (NO) in nonpregnant women and in normotensive pregnancies.
Platelet aggregation was studied with a dual-channel aggregometer and expressed as a percentage of light tra... | The L-Arg-NO system regulates platelet aggregation during pregnancy. Moreover, a physiologic reduction of platelet sensitivity to the antithrombotic effect of NO occurs.
That leads me to Yes. |
11,128,658 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Do antifilaggrin antibodies within `` normal '' range predict rheumatoid arthritis in a linea... | Increasing attention has been paid to the significance of antifilaggrin antibodies (AFA) in rheumatoid arthritis (RA). We studied the prediction of RA by AFA in serum specimens from the period prior to the onset of clinical RA.
A case-control study was nested within a Finnish cohort of 19.072 adults who had neither ar... | I'd call it Yes. AFA still within the "normal" range predicts RA in a linear fashion. AFA and RF are associated markers of the rheumatoid immunological process. |
11,066,139 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does estradiol administration after trauma-hemorrhage improve cardiovascular and hepatocellular functions in male animals? | To determine whether female sex steroids have any salutary effects on the depressed cardiovascular and hepatocellular functions following trauma and hemorrhage in male animals.
Studies indicate that gender difference exists in the immune and cardiovascular responses to trauma-hemorrhage, and that male sex steroids app... | Administration of estrogen appears to be a useful adjunct for restoring cardiovascular and hepatocellular functions after trauma-hemorrhage in male rats.
So overall I'd say Yes. |
9,305,556 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does tranexamic acid reduce blood loss and transfusion in reoperative cardiac surgery? | The objective of this study was to assess the effect of tranexamic acid (TA), a synthetic antifibrinolytic, on blood loss and the need for transfusion of blood products following repeat cardiac valve surgery.
After ethics committee approval, 41 patients scheduled for reoperative valve replacement were enrolled in this... | Conclusion Yes. Tranexamic acid reduced blood loss and the need for blood product transfusion and appears to be an effective treatment for patients undergoing reoperative cardiac valvular surgery. |
11,747,282 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does home testing of fructosamine improve glycemic control in patients with diabetes? | To determine whether weekly fructosamine testing at home by patients with type 2 diabetes, combined with therapeutic intervention when necessary on the basis of the results, would lead to improved glycemic control in comparison with usual care during a 3-month period.
In a prospective study, 25 patients with glycosyla... | I'd call it Yes. In the 3 months after a change in therapy for type 2 diabetes, weekly home testing of fructosamine, combined with therapeutic interventions based on the results, led to a more rapid and significant improvement in glycemic control than did the usual regimen of glucose-only testing. |
25,422,036 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is swarm motility of Salmonella enterica serovar Typhimurium inhibited by compounds from fruit peel extracts... | Controlling spread of human pathogens on fresh produce is a top priority for public health reasons. Isolation of compounds from agricultural waste that would control spread of human pathogens was explored using Salmonella enterica serovar Typhimurium as a model organism. In the environment, micro-organisms migrate as a... | Conclusion Yes. Controlling the spread of food-borne pathogens in moist environments is an important microbial food safety issue. Isolation of compounds from agricultural waste (such as fruit peels) that would control spread of human pathogens was explored using Salmonella enterica serovar Typhimurium as a model organi... |
21,529,839 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does vitamin E derivative ETS-GS reduce liver ischemia-reperfusion injury in rats? | Ischemic liver injury is often the result of surgical procedures such as liver transplantation and hepatic resection. Liver damage occurs after reperfusion, leading to increased systemic inflammation. Recent studies have reported that vitamin E and glutathione can ameliorate ischemia-reperfusion (I/R) injury. In the pr... | Taken together, our results demonstrate that ETS-GS attenuates I/R injury in a rat model and suggests that ETS-GS may exert anti-inflammatory effects. Accordingly, ETS-GS may have therapeutic potential to treat various clinical conditions involving I/R injury.
So overall I'd say Yes. |
10,360,868 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does halothane presynaptically depress synaptic transmission in wild-type Drosophila larvae but not in halot... | General anesthetics produce important changes in neural function, but the relation between the many individual changes produced by anesthetics in neural components and the responsiveness of the whole organism is uncertain. An analysis of genetically altered animals that have modified responses to volatile anesthetics m... | Conclusion Yes. Halothane depresses synaptic transmission at the wild-type Drosophila neuromuscular junction, most likely by affecting presynaptic properties. The absence of an effect by halothane in the har mutants provides evidence that the depression of presynaptic function at the glutamate-mediated synapses is an i... |
23,934,017 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is motor skill learning associated with diffusion characteristics of white matter in individuals with chronic stroke? | Imaging advances allow investigation of white matter after stroke; a growing body of literature has shown links between diffusion-based measures of white matter microstructure and motor function. However, the relationship between these measures and motor skill learning has not been considered in individuals with stroke... | Diffusion characteristics of posttraining ipsilesional PLIC were linked to the magnitude of change in skilled motor behavior. These results imply that the microstructural properties of regional white matter indexed by diffusion behavior may be an important factor to consider when determining potential response to rehab... |
12,504,973 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is mid-trimester severe intrauterine growth restriction associated with a high prevalence of thrombophilia? | To investigate the association between severe mid-trimester IUGR, whose causes are unknown in most cases, and maternal thrombophilias.
Case-control study.
Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University.
Twenty-six women with severe mid-trimester (22-26 ... | Women with mid-trimester severe IUGR have an increased prevalence of inherited and acquired thrombophilias.
That leads me to Yes. |
20,627,100 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is soluble receptor for advanced glycation end products ( sRAGE ) in plasma and synovial fluid inversely ass... | The aim of this study was to measure soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid of knee osteoarthritis (OA) patients and to determine the correlation between sRAGE levels and disease severity.
Thirty-six OA patients and 15 healthy controls were enrolled in this study. OA ... | Conclusion Yes. sRAGE levels were significantly lower in OA patients compared with controls, and sRAGE levels in plasma and synovial fluid also decreased significantly as the disease severity increased. Accordingly, sRAGE levels could be used as a biochemical marker for assessing the severity and progression of knee OA... |
16,235,460 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does intrathecal midazolam combined with low-dose bupivacaine improve postoperative recovery in diabetic mel... | Intrathecal midazolam acts synergically with other anesthetics to relieve surgical pain, and the drug combination may decrease complications attributable to each component drug. This prospective study was to determine the spinal effects of low-dose of bupivacaine (5 mg) combined with intrathecal midazolam (2 mg) in dia... | Conclusion Yes. The combination of intrathecal midazolam and bupivacaine was a safe and effective anesthetic technique, and it also provided early recovery of motor function and reduced the requirement of analgesics postoperatively. |
27,676,674 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does contrast Runoff correlate with the Clinical Outcome of Cervical Epidural Neuroplasty Usi... | Epidural neuroplasty using a Racz catheter has a therapeutic effect. Studies have found no correlation between foraminal stenosis and the outcome of epidural neuroplasty, which is thought to depend on contrast runoff.
To examine the correlation between the contrast spread pattern and pain reduction in cervical epidura... | I'd call it Yes. This study lacked a control group, and the patients were not classified by their diagnosed disease, such as spinal stenosis, herniated nucleus pulposus, and post-spinal surgery syndrome. |
26,111,756 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does bufalin inhibit the Differentiation and Proliferation of Cancer Stem Cells Derived from Primary Osteosa... | Osteosarcoma (OS) is the second leading cause of cancer-related death in children and young adults. Chemoresistance is the most important cause of treatment failure in OS, largely resulting from presence of cancer stem cells (CSCs). However, CSCs isolated from cancer cell lines do not necessarily represent those from p... | Conclusion Yes. Our data suggest that bufalin may be a promising treatment for OS, and its function may be conducted through regulation of miR-148a. |
9,736,884 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is hyaline membrane disease underreported in a linked birth-infant death certificate database? | This study compared the Missouri State Department of Health linked birth-infant death certificate database and medical records with respect to recording hyaline membrane disease in very low-birth-weight infants.
We reviewed the records for all 976 infants weighing 500 to 1500 g who were born to St. Louis, Mo, resident... | Conclusion Yes. The Missouri State Department of Health birth-infant death certificate database underestimates the incidence of hyaline membrane disease, which suggest that national statistics for the disease are also underestimated. |
25,581,573 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is tM6SF2 E167K variant associated with severe steatosis in chronic hepatitis C , regardless of PNPLA3 polymorphism? | A common non-synonymous polymorphism, E167K, in transmembrane six superfamily member 2 (TM6SF2) gene has been recently associated with an increased hepatic triglyceride content, dyslipidemia and liver fibrosis in NAFLD patients. We investigated possible associations between the TM6SF2 variants and liver lesions in chro... | This is the first demonstration that TM6SF2 E167K variant is an independent predictor of liver steatosis in chronic hepatitis C.
That leads me to Yes. |
8,238,172 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is coitus during pregnancy related to bacterial vaginosis or preterm birth? | Our goal was to assess the relationship between bacterial vaginosis and sexual intercourse and the impact of both on preterm birth.
The presence of bacterial vaginosis was assessed in 790 healthy nulliparous women between 8 and 17 weeks' gestation, and they were then asked to record weekly the number of occasions of s... | Conclusion No. For healthy nulliparous women, coitus during pregnancy is not related to bacterial vaginosis and does not predispose to preterm birth. |
17,126,343 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is serum C-reactive protein response to percutaneous coronary intervention in patients with unstable or stable angina pectoris associated with the risk of cl... | Inflammation plays a pivotal role in the pathogenesis of atherosclerosis. Previous reports have used vaccination as a model to stimulate inflammation. The aim of the present study was to investigate the role of C-reactive protein response to PCI in the risk of clinical restenosis or new coronary stenosis, considering P... | The CRP response to PCI, as a model to stimulate inflammation, is associated with an increased risk of clinical restenosis. The results emphasize the role of CRP in the pathogenesis of coronary artery disease progression and in particular restenosis.
So overall I'd say Yes. |
19,332,048 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Are polymorphisms of MMP-2 gene associated with systolic heart failure prognosis? | MMP-2 is a proteolytic enzyme involved in myocardial remodeling that occurs in congestive heart failure (HF). We hypothesized MMP-2 genetic variations could influence the prognosis of systolic HF.
To test our hypothesis, we performed a follow-up study of 605 patients with systolic HF. Three single nucleotide polymorph... | Conclusion Yes. The findings of the present study suggest that MMP-2 rs17859821 A allele was associated with better prognosis of systolic HF in the northern Han Chinese population. |
27,459,545 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does high Specificity in Circulating Tumor Cell Identification be Required for Accurate Evaluation of Programmed Death-Ligand 1? | Expression of programmed-death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) is typically evaluated through invasive biopsies; however, recent advances in the identification of circulating tumor cells (CTCs) may be a less invasive method to assay tumor cells for these purposes. These liquid biopsies rely on ac... | Interfering myeloid populations can be differentiated from true CTCs with additional staining criteria, thus improving the specificity of CTC identification and the accuracy of biomarker evaluation.
That leads me to Yes. |
26,215,776 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Are simultaneous bilateral multiligamentous knee injuries associated with more severe multisystem trauma com... | To compare the knee ligamentous injury patterns and associated multisystem trauma in patients who have sustained simultaneous bilateral knee multiligamentous injuries (MLI) to patients with unilateral MLIs.
Patients with simultaneous bilateral and unilateral knee MLIs after motor vehicle accidents were identified from... | Conclusion Yes. Compared to unilateral MLIs with similar mechanisms, patients with traumatic simultaneous bilateral knee multiligamentous knee injuries are at high risk of concomitant head, chest and abdominal injuries. Although the ligament injury profile is similar, the post-operative complication rate is higher for ... |
26,141,959 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does chromosomal copy number variation reveal differential levels of genomic plasticity in distinct Trypanosoma cruzi strains? | Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided into six discrete typing units (DTUs), named TcI-TcVI. CL Brener, the reference strain of the T. cruzi genome project, is a hybrid with a genome assembled into 41 putative chromosomes. Gene copy number variation (CNV) is well documented as a... | Increased gene copy number due to chromosome amplification may contribute to alterations in gene expression, which represents a strategy that may be crucial for parasites that mainly depend on post-transcriptional mechanisms to control gene expression.
So overall I'd say Yes. |
22,221,312 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does thiazolidinedione-dependent activation of sphingosine kinase 1 cause an anti-fibrotic effect in renal m... | PPARγ agonists [thiazolidinediones (TZDs)] are known to exert anti-fibrotic effects in the kidney. In addition, we previously demonstrated that sphingosine kinase 1 (SK-1) and intracellular sphingosine-1-phosphate (S1P), by reducing the expression of connective tissue growth factor (CTGF), have a protective role in the... | Conclusion Yes. These data show that TZD-induced SK-1 up-regulation results in lower amounts of CTGF, demonstrating novel facets for the anti-fibrotic effects of this class of drugs. |
10,618,306 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is plasminogen activator inhibitor 4G polymorphism associated with decreased risk of cerebrov... | A common 4G allele of a 4G/5G polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene is associated with increased transcription of the PAI-1 protein, which may lead to decreased fibrinolysis. It has therefore been proposed as a candidate risk factor for myocardial infarction or stroke... | I'd call it Yes. These findings are suggestive of an important contribution of PAI-1 in cerebrovascular pathology, probably via pathways other than fibrinolysis. PAI-1 may protect against destabilization of the atherosclerotic plaque, or it may inhibit neurotoxicity of tissue plasminogen activator in the brain. |
17,324,777 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does cyclic mechanical strain increase production of regulators of bone healing in cultured murine osteoblasts? | The adaptive response of bone to mechanical strain, for which angiogenesis is required, is underscored during fracture healing. Vascular endothelial growth factor (VEGF) and transforming growth factor beta-1 (TGF-beta1) are critical regulators of angiogenesis. The purpose of this study was to examine the effect of stra... | We demonstrated simultaneous, dose-dependent increases in VEGF and TGF-beta1 protein production by osteoblastic cells in response to increasing strain. VEGF mRNA also increased in response to strain. This strain-induced increase in angiogenic cytokines suggests a potential mechanism by which injured bone may recruit a ... |
26,586,019 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is current tobacco use associated with higher rates of implant revision and deep infection after total hip or knee arthroplasty : a prospective cohort study? | Tobacco smoking is a risk factor for several adverse post-operative outcomes. We aimed to compare the rates of complications in current tobacco users and non-users who underwent primary total hip arthroplasty (THA) or total knee arthroplasty (TKA).
All patients who underwent primary THA or TKA at the Mayo Clinic from ... | We noted that current tobacco use was associated with high risk of deep infection and implant revision after primary THA or TKA. Future studies should determine the optimal time for tobacco use cessation before elective surgeries such as THA and TKA to improve short-term and long-term arthroplasty outcomes.
So overall... |
23,667,632 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is glioma cell death induced by irradiation or alkylating agent chemotherapy independent of the intrinsic ce... | Resistance to genotoxic therapy is a characteristic feature of glioma cells. Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and glucosylceramide synthase (GCS) catalyzes ceramide metabolism. Increased ceramide levels have been suggested to enhance chemotherapy-induced death of cancer cells.
Microarra... | Conclusion Yes. Modulation of intrinsic glioma cell ceramide levels by ASM overexpression or GCS inhibition does not enhance the anti-glioma activity of alkylating chemotherapy or irradiation. |
12,168,837 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is butyrate-enhanced TNFalpha-induced apoptosis associated with inhibition of NF-kappaB? | Tumor necrosis factor (TNFalpha)-induced apoptosis is limited by concomitant activation of nuclear factor kappa B (NF-kappaB)-dependent anti-apoptotic genes. Butyrate inhibits NF-kappaB activation so that co-treatment with butyrate effectively enhances TNFalpha-induced apoptosis. In this context, the inhibition of NF-k... | Butyrate enhances TNFalpha-induced apoptosis in the human adenocarcinoma cell line SW620. This additive effect may, at least in part, be mediated by the inhibition of NF-kappaB activation, presumably by impairing the anti-apoptotic properties of NF-kappaB.
That leads me to Yes. |
16,140,366 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is expression of estrogen-responsive finger protein ( Efp ) associated with advanced disease ... | The estrogen-responsive ring finger protein (Efp) gene, one of estrogen receptor (ER) target genes, is considered to be essential for estrogen-dependent cell proliferation. To understand the estrogenic action on ovarian cancer, we studied the relationships between Efp and ERs expressions and the correlations of Efp exp... | I'd call it Yes. The expression of Efp was detected in human epithelial ovarian cancer and high expression of Efp was correlated with advanced disease and serous adenocarcinoma, and ERs status. |
16,519,813 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does use of private gynaecologist relate to better prevention outcomes - an ecological analysis from Finland? | Control of reproduction and prevention of reproductive health problems are important reasons for women to use health services, but the proper organisational level of service provision is not clear. The purpose of this study was to investigate whether visits to private gynaecologists correlate with better health outcome... | This ecological analysis suggests that frequent use of private gynaecologists relates somewhat to lower organised screening for cancer participation, and is not better in preventing abortions or in detecting cancer earlier. Our results suggest that a planned system relying mainly on general practitioners and public hea... |
15,007,085 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does azacitidine induce demethylation of the Epstein-Barr virus genome in tumors? | To determine whether therapy with a DNA methyltransferase inhibitor is effective in achieving demethylation and gene re-expression in tumor DNA in patients.
Biopsy specimens were obtained from patients with Epstein-Barr virus-associated tumors, enrolled on a clinical trial of 5-azacitidine, within 72 hours of the conc... | Pharmacologic reversal of dense CpG methylation in tumor tissue can be achieved in patients.
That leads me to Yes. |
7,978,486 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does subarachnoid morphine reduce stimulation-induced but not basal expression of preproenkep... | To evaluate directly the possibility that the potent exogenous opioid analgesic morphine may alter neuronal expression of opioid peptide genes, we assessed the effect of subarachnoid morphine on basal and noxious stimulation-induced expression of preproenkephalin in spinal cord neurons.
Twenty male Sprague-Dawley rats... | I'd call it Yes. Subarachnoid morphine does not acutely alter basal expression of preproenkephalin in spinal cord neurons but inhibits the increase in preproenkephalin expression that would otherwise occur after noxious stimulation. |
21,853,148 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is somaclonal variation induced de novo via the tissue culture process : a study quantifying mutated cells i... | The origin of somaclonal variation has not been questioned previously, i.e., "pre-existing mutations" in explants and "newly induced mutations" arising from the tissue culture process have not been distinguished. This is primarily because there has been no reliable molecular method for estimating or quantifying variati... | Conclusion Yes. The estimation of mutated cell percentages became possible using the quantitative real-time PCR. The origins of mutations were successfully distinguished; it was confirmed that somaclonal variations are mainly caused by newly generated mutations arising from tissue culture process. |
14,967,723 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does reoxygenation of hypoxic coronary smooth muscle cells amplify growth-retarding effects of ionizing irradiation? | Hypoxic human coronary smooth muscle cells (HCSMCs) are possible targets for brachytherapy to prevent restenosis after percutaneous transluminal coronary angiography. It is unclear whether growth kinetics and gene expression of these cells undergoing gamma-irradiation are changed by reoxygenation.
Hypoxic (H) and hypo... | Reoxygenation of hypoxic HCSMCs markedly amplifies growth-retarding effects of ionizing irradiation. On the basis of these findings, oxygenating radiosensitizers should be analyzed with regard to suitability for coronary brachytherapy to prevent restenosis.
So overall I'd say Yes. |
21,334,995 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does simvastatin stimulate apoptosis in cholangiocarcinoma by inhibition of Rac1 activity? | Simvastatin is a cholesterol-lowering drug that is widely used to prevent and treat atherosclerotic cardiovascular disease. Simvastatin exhibits numerous pleiotropic effects including anti-cancer activity. However, the effect of simvastatin on cholangiocarcinoma has not been evaluated.
The aim of our study was to dete... | Collectively, our results demonstrate that simvastatin induces cholangiocarcinoma cancer cell death by disrupting Rac1/lipid raft colocalisation and depression of Rac1 activity.
So overall I'd say Yes. |
16,546,078 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does the Arabidopsis MAX pathway control shoot branching by regulating auxin transport? | Plants achieve remarkable plasticity in shoot system architecture by regulating the activity of secondary shoot meristems, laid down in the axil of each leaf. Axillary meristem activity, and hence shoot branching, is regulated by a network of interacting hormonal signals that move through the plant. Among these, auxin,... | I'd call it Yes. The MAX-dependent hormone is a novel regulator of auxin transport. Modulation of auxin transport in the stem is sufficient to regulate bud outgrowth, independent of AXR1-mediated auxin signaling. We therefore propose an additional mechanism for long-range signaling by auxin in which bud growth is regul... |
1,959,184 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is aspirin-induced decline in prostacyclin production in patients with coronary artery disease due to decrea... | It was the purpose of this study to determine the effects of the combination of aspirin (ASA) and fish oil, which is rich in n-3 polyunsaturated fatty acids, on the eicosanoid profile of patients with coronary artery disease. Specifically, we wanted to determine whether the ASA-induced reduction in prostacyclin product... | Conclusion Yes. Moderate-dose (325 mg per day or less) ASA taken once daily has no effect on PGI3 production despite significantly reducing PGI2 production. This suggests that endothelial cell cyclooxygenase is minimally inhibited by such doses of ASA and that a large percent of the PGI2 produced in patients with advan... |
25,886,087 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is use of off-label doses frequent in biologic therapy for moderate to severe psoriasis : A cross-sectional study in clinical practice? | Biologic medications increase dramatically the burden of a chronic and high prevalent disease like psoriasis. The objective of the study was to quantify the use of dose reduction or dose escalation strategies, not reflected in the drug summary of product characteristics, in clinical practice.
An observational, cross-s... | Off-label doses of biologic agents for psoriasis are frequent in clinical practice. This information is especially relevant for pharmacoeconomic models.
So overall I'd say Yes. |
16,600,417 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is interleukin-6 a key mediator of the hepatoprotective and pro-proliferative effects of ischaemic preconditioning in mice? | The biological effects of ischaemic preconditioning include NF-kappaB activation, increased TNF synthesis, stimulation of cell cycle entry and hepatoprotection against ischaemia-reperfusion (IR) injury. Low dose TNF initiates the priming phase of liver regeneration via NF-kappaB and IL-6. To determine whether (1) IL-6 ... | IL-6 is one likely mediator of the hepatoprotective and pro-proliferative effects of ischaemic preconditioning.
That leads me to Yes. |
27,193,563 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Do weight Change and Obesity Are Associated with a Risk of Adenoma Recurrence? | Obesity is reportedly a risk factor for colorectal adenoma. However, the influence of weight change and obesity on colorectal adenoma recurrence is unclear.
To investigate whether weight change and obesity are associated with recurrence and development of colorectal adenoma.
Of 62,171 asymptomatic subjects who underw... | Weight change over 2.2 years affected adenoma recurrence and obesity was related to advanced adenoma recurrence and adenoma development.
So overall I'd say Yes. |
17,465,503 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is expression of p21 ( WAF1 ) related to acetylation of histone H3 in total chromatin in human colorectal cancer? | To explore the relationship between acetylation of histone in total chromatin and p21(WAF1) expression regulation in human colorectal carcinoma.
We analyzed the expression of tumor suppressor gene p21(WAF1) mRNA by RT-PCR or real-time PCR in 33 samples of colorectal cancerous tissue, corresponding para-cancerous tissu... | The down-regulation of p21(WAF1) transcription is involved in the tumorigenesis and development of colorectal carcinoma. The down-expression of p21(WAF1) mRNA in colorectal carcinoma might be associated with histone hypoacetylation in chromatin but not with biological behaviors.
So overall I'd say Yes. |
15,850,448 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Are aquaporin-1 and -9 differentially regulated by oestrogen in the efferent ductule epithelium and initial ... | Efferent ductules reabsorb more than 90% of the rete testis fluid, a process that involves ion transporters and AQP (aquaporin) water channels. Oestrogen has been shown to modulate the expression of the ion transporters involved in this activity, but reports of AQP regulation in the male tract have been confounding. To... | Conclusion Yes. These results demonstrate that efferent ductules are unique in requiring both oestrogen and androgen to regulate an important mediator of fluid reabsorption, whereas the initial segment is dependent only on androgen stimulation. |
18,239,382 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does low-dose local kidney irradiation inhibit progression of experimental crescentic nephrit... | Crescentic glomerulonephritis is a rapidly progressive form of nephritis and is usually resistant to therapeutic intervention. Apoptosis plays a role in the resolution of glomerulonephritis. We investigated the effects of local kidney irradiation on the progression of experimental crescentic glomerulonephritis.
The fo... | I'd call it Yes. Our study showed that renal radiation can alter acute glomerular inflammation by inducing apoptosis of intrinsic and infiltrating cells in the kidney in a rat model of crescentic glomerulonephritis. Low-dose kidney irradiation can inhibit the progression of experimental nephritis through inducing apopt... |
24,044,699 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is the level of leisure time physical activity associated with work ability-a cross sectional and prospective study of health care workers? | With increasing age, physical capacity decreases, while the need and time for recovery increases. At the same time, the demands of work usually do not change with age. In the near future, an aging and physically changing workforce risks reduced work ability. Therefore, the impact of different factors, such as physical ... | The level of physical activity seems to be related to work ability. Assessment of physical activity may also be useful as a predictive tool, potentially making it possible to prevent poor work ability and improve future work ability. For employers, the main implications of this study are the importance of promoting and... |
26,018,800 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Do ω3-polyunsaturated fatty acids suppress lipoprotein-associated phospholipase A2 expression in macrophages... | ω3-polyunsaturated fatty acids (ω3-PUFAs) have beneficial effects on cardiovascular function, and lipoprotein-associated phospholipase A2 (Lp-PLA2 ) is associated with the risk of cardiovascular disease. Here, we investigated the effects of ω3-PUFAs on Lp-PLA2 expression in vitro and in vivo and explored the mechanisms... | Conclusion Yes. Our results demonstrate that the protective effects of ω3-PUFAs against cardiovascular events may be related to the suppression of Lp-PLA2 levels. |
10,846,125 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Do salivary epidermal growth factor levels decrease in patients receiving radiation therapy to the head and neck? | The objective of this study was to assess changes in salivary epidermal growth factor (EGF) in patients receiving radiation therapy to the head and neck and to determine whether salivary EGF levels correlate with the severity of radiation-induced oral mucositis.
Thirteen patients and 18 control subjects were enrolled ... | A strong negative correlation between normalized EGF and mucositis severity suggests a possible role for EGF in the progression of radiation-induced mucosal breakdown.
That leads me to Yes. |
20,350,296 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does the neuroepithelial basement membrane serve as a boundary and a substrate for neuron migration in the z... | The facial branchiomotor neurons of cranial nerve VII undergo a stereotyped tangential migration in the zebrafish hindbrain that provides an ideal system for examining the complex interactions between neurons and their environment that result in directed migration. Several studies have shown the importance of the plana... | Conclusion Yes. Our results suggest that the laminin-containing ventral basement membrane, dependent on the activity of the PAR-aPKC complex in the hindbrain neuroepithelium, is both a substrate for migration and a boundary that constrains facial branchiomotor neurons to the appropriate migratory path. |
25,444,379 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does polyphenol-enriched diet prevent coronary endothelial dysfunction by activating the Akt/eNOS pathway? | The Mediterranean diet, rich in polyphenols, has shown to be cardioprotective. However the mechanisms involved remain unknown. We investigated whether supplementation with a pomegranate extract rich in polyphenols renders beneficial effects on coronary function in a clinically relevant experimental model and characteri... | Pomanox supplementation hinders hyperlipemia-induced coronary endothelial dysfunction by activating the Akt/endothelial nitric oxide-synthase pathway and favorably counteracting vascular inflammation and oxidative damage.
So overall I'd say Yes. |
22,074,289 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is dynamic hyperinflation associated with a poor cardiovascular response to exercise in COPD patients? | Pulmonary hyperinflation has the potential for significant adverse effects on cardiovascular function in COPD. The aim of this study was to investigate the relationship between dynamic hyperinflation and cardiovascular response to maximal exercise in COPD patients.
We studied 48 patients (16F; age 68 yrs ± 8; BMI 26 ±... | The present study shows that COPD patients with dynamic hyperinflation have a poor cardiovascular response to exercise. This finding supports the view that in COPD patients, dynamic hyperinflation may affect exercise performance not only by affecting ventilation, but also cardiac function.
That leads me to Yes. |
16,318,625 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does computational modeling reveal molecular details of epidermal growth factor binding? | The ErbB family of receptors are dysregulated in a number of cancers, and the signaling pathway of this receptor family is a critical target for several anti-cancer drugs. Therefore a detailed understanding of the mechanisms of receptor activation is critical. However, despite a plethora of biochemical studies and rece... | Our computer simulations reveal the mechanism of EGF binding on EGFR. Overall, we show that spatial simulation of receptor dynamics can be used to gain a mechanistic understanding of receptor activation which may in turn enable improved cancer treatments in the future.
That leads me to Yes. |
20,136,697 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Are paxillin expression levels correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma? | To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC).
A total of 47 SACC were assessed histochemically for paxillin expression. Paxillin immunoreactivity was compared with histological type, clinical stage and distant me... | Our observations indicate that paxillin expression is upregulated in SACC. High expression of paxillin was correlated with a more advanced stage and metastasis in SACC, suggesting that paxillin is a disease marker in advanced SACC and SACC with distant metastasis, and, consequently, may have value as a therapeutic targ... |
17,306,649 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is distribution of cervical intraepithelial neoplasia across the cervix random? | This study was undertaken to assess the validity of an assumption that histologically confirmed cervical intraepithelial neoplasia (CIN) lesions are not randomly distributed across the cervix.
This retrospective study included 359 women ranging in age from 17-81 years (mean +/- SD, 34.4 +/- 12.1 years) who underwent c... | Contrary to previous assumptions, histologically confirmed CIN lesions are randomly distributed across the cervix site.
That leads me to Yes. |
18,775,714 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Do mEN1 missense mutations impair sensitization to apoptosis induced by wild-type menin in en... | Missense mutations account for 30% of mutations identified in patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome. They raise several issues: the distinction between pathogenic mutations and polymorphisms is sometimes difficult and the functional effects of missense mutations are unclear. We aimed to ... | I'd call it Yes. Taking advantage of a new endocrine cellular model, we show a loss of function for 2 missense disease-related menin mutants and for a controversial variant as well. Furthermore, our results suggest the existence of functional interactions between p53 and menin for the control of apoptosis, which may ca... |
24,910,417 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is actinomycin D , cisplatin , and etoposide regimen associated with almost universal cure in patients with high-risk gestational trophoblastic neoplasia? | Patients with high-risk gestational trophoblastic neoplasia (GTN) need multi-agent chemotherapy to be cured. The most common regimen is etoposide (E), methotrexate (M) and actinomycin D (A), alternating weekly with cyclophosphamide (C) plus vincristine (O) (EMA/CO). Cisplatin (P) is a very active drug, but it is usuall... | With a 97% long-term overall survival rate, limited long-term toxicity, and an excellent reproductive outcome, APE could be regarded as an alternative option to EMA/CO as a standard therapy for high-risk GTN.
That leads me to Yes. |
24,968,990 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is long-term air humidification therapy cost-effective for patients with moderate or severe c... | To establish the cost-effectiveness of long-term humidification therapy (LTHT) added to usual care for patients with moderate or severe chronic obstructive pulmonary disease or bronchiectasis.
Resource usage in a 12-month clinical trial of LTHT was estimated from hospital records, patient diaries, and the equipment su... | I'd call it Yes. LTHT is moderately cost-effective for patients with moderate to severe chronic obstructive pulmonary disease or bronchiectasis at a WTP threshold that is acceptable for public funding of medicines in New Zealand. These findings must be interpreted with caution because of the modest size of the clinical... |
23,043,617 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does pearl extract enhance the migratory ability of fibroblasts in a wound healing model? | For 2000 years, traditional Chinese medicine has been used as a remedy for general health improvement, including the fight against aging. Pearl powder has recently been used as a health food that has antioxidant, antiaging, antiradioactive, and tonic activities for cells; it is also applied to cure aphthous ulcer, gast... | The present study found that the migration-promoting effect in PL, which could be a supplement in cell culture. These data suggest PL could be useful for enhancing the wound healing of fibroblasts.
That leads me to Yes. |
25,341,381 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does multi-scale symbolic entropy analysis provide prognostic prediction in patients receiving extracorporeal life support? | Extracorporeal life support (ECLS) can temporarily support cardiopulmonary function, and is occasionally used in resuscitation. Multi-scale entropy (MSE) derived from heart rate variability (HRV) is a powerful tool in outcome prediction of patients with cardiovascular diseases. Multi-scale symbolic entropy analysis (MS... | MSsE provides additional prognostic information in patients receiving ECLS.
That leads me to Yes. |
22,192,385 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Do plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India? | The mechanisms underlying the pathogenesis of cerebral malaria (CM) syndrome are not well understood. Previous studies have shown a strong association of inflammatory chemokines, apoptotic markers and angiogenic molecules with CM associated mortality. Recognizing the importance of angiopoietins (ANG) in the pathogenesi... | These results suggest that at the time of admission plasma levels of ANG-2 and ratio of ANG-2/ANG-1 are clinically informative biomarkers to predict fatal CM from MM cases while they have limited usefulness in discriminating fatal CM outcomes in a pool of CM cases in endemic settings of Central India.
That leads me to... |
17,391,000 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does hyperthermia enhance tumour necrosis factor-related apoptosis-inducing ligand ( TRAIL ) -induced apopto... | This study investigated whether hyperthermia can enhance TRAIL-induced apoptotic death.
Human prostate adenocarcinoma DU-145, human pancreatic carcinoma MIA PaCa-2 and BxPC-3, human colon fibroblast CCD-33Co and rat prostate endothelial YPEN-1 cells were treated with various concentrations of TRAIL (0-200 ngml(-1)) wi... | Conclusion Yes. These data suggest that cancer cells are more susceptible to TRAIL in the condition of hyperthermia (40-42 degrees C). The promotion of caspase enzyme activity by hyperthermia may be responsible for enhancement of TRAIL-induced apoptotic death. |
23,241,174 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does the hemicellulolytic enzyme arsenal of Thermobacillus xylanilyticus depend on the compos... | Thermobacillus xylanilyticus is a thermophilic and highly xylanolytic bacterium. It produces robust and stable enzymes, including glycoside hydrolases and esterases, which are of special interest for the development of integrated biorefineries. To investigate the strategies used by T. xylanilyticus to fractionate plant... | I'd call it Yes. This study provides insight into the ability of T. xylanilyticus to grow on abundant agricultural by-products, which are inexpensive carbon sources for enzyme production. The composition of the biomass upon which the bacteria grew influenced their growth, and differences in the biomass provided resulte... |
24,902,772 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does circumstances and causes of fall by patients at a Spanish acute care hospital? | A major problem in hospitals is that of falls, which can seriously reduce patients' quality of life. Fall rates vary considerably depending on health care practices, the hospital environment and the measurement method used. The aim of this study was to determine the characteristics of hospitalized acute patients who su... | Conclusion Yes. Falls have diverse causes. Determining these circumstances can contribute to promoting a culture of prevention and to reducing the injuries provoked by falls. Notification procedures should be standardized in order to enable comparisons among different environments. |
11,588,325 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does endothelium-derived endothelin-1 reduce cerebral artery sensitivity to nitric oxide by a protein kinase C-independent pathway? | Nitric oxide (NO) reduces endothelin-1 (ET-1) production and blunts ET-1 dependent vasoconstriction. The direct effects of smooth muscle ET(A) receptor stimulation on NO-mediated relaxation are unknown. We hypothesized that endothelium-derived ET-1 regulates vascular tone by reducing smooth muscle sensitivity to NO, po... | Blockade of ET(A) but not ET(B) receptors sensitizes vascular smooth muscle to exogenous and endothelium-derived NO. This suggests that ET-1 regulates smooth muscle sensitivity to NO by a PKC-independent pathway. This represents an alternative pathway by which NO and ET-1 interact to regulate vascular tone.
That leads... |
19,275,099 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Do [ Screening human keratinocyte growth factor mimic peptide with Ph.D.-7 phage display peptide library ]? | To harvest human keratinocyte growth factor (KGF) mimic peptides with Ph.D.-7 phage display peptide library.
Ph.D.-7 phage display peptide library was biopanned for 4 rounds to harvest monoclonal anti-body human KGF and then phage titer was detected. ELISA detection was performed to detect the binding force of random-... | The phage mimic peptides resembling or related to human KGF DNA can be harvested from Ph.D.-7 phage display peptide library, which may be conducive to improve human KGF performance, wound healing and the quality of tissue engineered skin substitutes.
So overall I'd say Yes. |
24,929,195 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is proinflammatory milieu in combat-related PTSD independent of depression and early life stress? | Chronic inflammation may be involved in combat-related post-traumatic stress disorder (PTSD) and may help explain comorbid physical diseases. However, the extent to which combat exposure per se, depression, or early life trauma, all of which are associated with combat PTSD, may confound the relationship between PTSD an... | Combat-related PTSD in males is associated with higher levels of pro-inflammatory cytokines, even after accounting for depression and early life trauma. These results, from one of the largest studies of inflammatory cytokines in PTSD to date, suggest that immune activation may be a core element of PTSD pathophysiology ... |
24,845,399 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Are expressions of tight junction proteins Occludin and Claudin-1 under the circadian control in the mouse large intestine : implications in intestinal perme... | The circadian clock drives daily rhythms in behavior and physiology. A recent study suggests that intestinal permeability is also under control of the circadian clock. However, the precise mechanisms remain largely unknown. Because intestinal permeability depends on tight junction (TJ) that regulates the epithelial par... | Occludin and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis.
So overall I'd say Yes. |
22,233,138 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is cancer-associated ischemic stroke associated with elevated D-dimer and fibrin degradation ... | Although several studies have reported various causes of ischemic stroke in patients with cancer, only a few have evaluated the clinical relevance of ischemic stroke pathogenesis to cancer. The aim of the present study was to elucidate the clinical characteristics of cancer-associated ischemic stroke.
We evaluated 154... | I'd call it Yes. In acute ischemic stroke, the cancer-associated ischemic stroke is associated with elevated D-dimer and fibrin degradation products, even after controlling hypertension, hyperlipidemia and advanced cancer (clinical stage IV). |
19,476,621 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does progesterone receptor improve the performance and test effectiveness of the conventional 3-marker panel , consisting of estrogen receptor , vimentin and carcinoembr... | Endocervical adenocarcinomas (ECA) and endometrial adenocarcinomas (EMA) are uterine malignancies that have differing biological behaviors. The choice of an appropriate therapeutic plan rests on the tumor's site of origin. In this study, we propose to evaluate whether PR adds value to the performance and test effective... | According to our data, when histomorphological and clinical doubt exists as to the primary site of origin, we recommend that the conventional 3-marker (ER/Vim/CEA) panel is easier, sufficient and appropriate to use in distinguishing between primary ECA and EMA. Although the 4-marker panel containing PR also reveals sta... |
24,435,467 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Do gamma-linolenic acid levels correlate with clinical efficacy of evening primrose oil in patients with atopic dermatitis? | Atopic dermatitis (AD) has been related to a deficiency of delta-6-desaturase, an enzyme responsible for the conversion of linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) contains high amounts of GLA. Therefore, this study investigated whether EPO supplementation results in an increase in plasma... | The clinical disease activity under EPO treatment correlates with the individual increase in plasma GLA levels. Thus, the results of this pilot study indicate that an increase in plasma GLA might be used as predictive parameter for responsiveness of AD to EPO therapy.
So overall I'd say Yes. |
26,014,607 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is cardiopulmonary fitness related to disease severity in multiple sclerosis? | In persons with MS (pwMS), a lower cardiopulmonary fitness has been associated with a higher risk for secondary disorders, decreased functional capacity, symptom worsening and reduced health-related quality of life.
To investigate the association between disease severity and cardiopulmonary fitness.
Data from cardiop... | There was a significant association between disease severity and cardiopulmonary fitness. The close relation between cardiopulmonary fitness and chronic conditions associated with physical inactivity, suggest a progressive increase in risk of secondary health conditions in pwMS.
So overall I'd say Yes. |
27,637,829 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does state challenge to child health quality measure reporting and recommendations for improvement? | The Children's Health Insurance Program (CHIP) was re-authorized in 2009, ushering in an unprecedented focus on children's health care quality one of which includes identifying a core set of performance measures for voluntary reporting by states' Medicaid/CHIP programs. However, there is a wide variation in the quantit... | Based on state responses, possible solutions to improve reporting includes funding and staff support, refining the technical assistance provided, and creating venues for state-to-state interaction. Realistic and tangible improvements are within reach and opportunities for CMS and states to collaborate to improve child ... |
8,625,633 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does small-volume resuscitation restore hemorrhage-induced microcirculatory disorders in rat pancreas? | Pancreatic hypoxia/ischemia, as a consequence of shock-induced microcirculatory failure, is considered a causative factor in the initiation and/or progression of pancreatic tissue injury. The aim of this study was to compare the effects of "small volume resuscitation" with conventional isovolemic colloid and hypervolem... | Despite replacement of only 10% of actual blood loss, small-volume resuscitation with hypertonic hydroxyethyl starch is as effective as the ten-fold volume of isotonic hydroxyethyl starch and, due to prevention of microvascular endothelial cell swelling, superior to the 40-fold volume of isotonic lactated Ringer's solu... |
11,006,889 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does a common polymorphism in methionine synthase reductase increase risk of premature coronary artery disease? | Methionine synthase reductase (MTRR) catalyzes the regeneration of methylcobalamin, a cofactor of methionine synthase, an enzyme essential for maintaining adequate intracellular pools of methionine and tetrahydrofolate, as well as for maintaining homocysteine concentrations at nontoxic levels. We recently identified a ... | Our findings suggest that the GG genotype of MTRR is a significant risk factor for the development of premature CAD, by a mechanism independent of the detrimental vascular effects of hyperhomocysteinemia. This association needs to be confirmed in other studies.
That leads me to Yes. |
18,978,678 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does candidate gene/loci studies in cleft lip/palate and dental anomalies found novel suscept... | We revisited 42 families with two or more cleft-affected siblings who participated in previous studies. Complete dental information was collected to test the hypothesis that dental anomalies are part of the cleft phenotype spectrum, and can provide new opportunities for identification of cleft susceptibility genes.
Ge... | I'd call it Yes. These findings support the hypothesis that some loci may contribute to both clefts and congenital dental anomalies. Thus, including dental anomalies information in the genetics analysis of cleft lip and palate will provide new opportunities to map susceptibility loci for clefts. |
12,928,122 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is neuron-specific enolase an effective tumour marker in non-small cell lung cancer ( NSCLC )... | Neuron-specific enolase (NSE) is a well known marker of small cell lung cancer. The present study was designed to assess the clinical value of NSE in non-small cell lung cancer (NSCLC), as compared to that of carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA).
The study comprised 448 new consecutive N... | I'd call it Yes. This data indicates that serum assay of NSE is a useful marker also in NSCLC and a significant predictor of survival, independently of the other prognostic factors. |
23,110,194 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is dimethylarginine dimethylaminohydrolase1 an organ-specific mediator of end organ damage in... | The endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) is an independent predictor of cardiovascular and overall mortality. Moreover, elevated ADMA plasma concentrations are associated with the extent of hypertension. However, data from small-sized clinical trials and experimental approaches ... | I'd call it Yes. Our data reveal that hDDAH1 organ-specifically modulates the inflammatory response in this murine model of hypertension. The lack of protection in cardiac and aortic tissues may be due to DDAH1 tissue selectivity and/or the extent of hypertension by the used combined model. However, our study underline... |
20,184,533 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Are c-reactive protein variants associated with susceptibility to stroke and stroke recurrence? | C-reactive protein (CRP) has been shown to contribute to the risk of cardiovascular disease. Several single nucleotide polymorphisms (SNPs) at the CRP locus have been found to be associated with CRP concentrations. We hypothesized that genetic variants associated with high CRP may confer a greater risk of stroke and re... | Although these variants and corresponding haplotypes in the CRP gene are associated with serum CRP concentrations, our study does not support that variants and corresponding haplotypes studied here have a major influence on risk of stroke and stroke recurrence. Therefore, we speculate that CRP is not a causal factor fo... |
25,227,556 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is local gentamicin delivery from resorbable viscous hydrogels therapeutically effective? | Local delivery can achieve the high antimicrobial concentrations necessary to kill biofilm-related microbes. Degradation times for resorbable carriers are too long. Hydrogels (gels of hydrophilic polymer in water) can degrade faster but release antimicrobials too quickly. We previously developed hydrogels based on the ... | Conclusion Yes. Gentamicin is delivered from PNDJ hydrogel with low systemic exposure and decreased treatment failure for orthopaedic infection. Transient renal dysfunction occurs at high doses. Biodistribution and toxicity testing are needed for G-PNDJ to be clinically usable. |
19,676,146 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is vitamin B12 deficiency associated with coronary artery disease in an Indian population? | The incidence of coronary artery disease (CAD) is increasing at an alarming rate, especially in developing countries, such as India. It is often advocated that a vegetarian lifestyle could reduce the burden of CAD. However, in spite of a majority of Indians being vegetarians, the incidence of CAD is highest in this pop... | I'd call it Yes. We believe that, when vitamin B12 is deficient, homocysteine is rapidly metabolized via the transsulfuration pathway leading to increased cysteine levels. |
21,432,309 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does low fasting serum insulin in Japanese alcohol consumers imply improved coronary risk factors? | The effects of alcohol consumption on coronary risk factors (CRFs) and insulin resistance (IR) have seemed equivocal in previous studies. This study aimed to clarify the implications of low fasting blood insulin observed in alcohol consumers as related to CRFs and IR.
A cross-sectional observation in 2133 middle-aged ... | Low fasting serum insulin observed in drinkers does not imply improved CRFs, and thus may not imply improved IR. High serum GGT may reflect increased IR in both drinkers and nondrinkers.
That leads me to No. |
17,541,276 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does theophylline attenuate the neutrophil-dependent augmentation of eosinophil trans-basement membrane migr... | Recent evidence suggests that both neutrophilic and eosinophilic inflammation persist in the airways of patients with severe asthma. Neutrophils can secrete a variety of mediators which may augment the migration of eosinophils. We have reported that activated neutrophils augment the trans-basement membrane migration (T... | Conclusion Yes. Our results show that theophylline can attenuate the neutrophil-dependent augmentation of eosinophil TBM. This effect is possibly attributable to the suppression of neutrophil activation provoked by the combination of basement membrane and IL-8. |
25,889,954 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Do mosquito host preferences affect their response to synthetic and natural odour blends? | The anthropophilic malaria mosquito Anopheles gambiae sensu stricto (hereafter termed Anopheles gambiae) primarily takes blood meals from humans, whereas its close sibling Anopheles arabiensis is more opportunistic. Previous studies have identified several compounds that play a critical role in the odour-mediated behav... | I'd call it Yes. Different odour baits elicit varying responses among mosquito species. Synthetic odour blends are highly effective for trapping mosquitoes; however, not all mosquitoes respond equally to the same odour blend. Combining fermenting molasses with synthetic blends in a trap represents the most effective to... |
16,832,771 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does [ ApoE genotype influence on efficacy and safety of thrombolytic treatment for ischemic stroke ]? | Apolipoprotein E has been associated with intracerebral hemorrhages and with neurological outcome of ischemic stroke patients treated with rt-PA. Therefore, we hypothesized that ApoE genotype might influence the appearance of post-tPA hemorrhagic transformation and that the favorable outcome of E2 patients might be due... | In our group of stroke patients, ApoE genotypes are not related with the presence of hemorrhagic transformations neither with the rates of recanalization following thrombolytic treatment.
So overall I'd say Yes. |
10,907,644 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does all-trans-retinoic acid induce tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leuk... | All-trans-retinoic acid (RA) is a potent inducer of differentiation of acute promyelocytic leukemia (APL) cells in vitro and in vivo. It also exhibits synergistic effects with interferons on the induction of differentiation and growth inhibition in vitro. Recent studies showed that interferons engage a signaling pathwa... | Conclusion Yes. These findings demonstrate that the CBL-CrkL pathway is one of the mediators of the effects of RA on APL cells and suggest that one of the mechanisms of synergy between RA and interferons may involve regulation of components of this signaling cascade. |
20,456,284 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Are metabolic syndrome abnormalities associated with severity of anxiety and depression and with tricyclic a... | The metabolic syndrome (MetSyn) predisposes to cardiovascular disease and diabetes mellitus. There might also be an association between the MetSyn and anxiety and depression, but its nature is unclear. We aimed to investigate whether diagnosis, symptom severity and antidepressant use are associated with the MetSyn.
We... | Conclusion Yes. The most severely depressed people and TCA users more often have the MetSyn, which is driven by abdominal adiposity and dyslipidemia. |
22,248,662 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is response of the upper esophageal sphincter to esophageal distension affected by posture , ... | Studies of the pressure response of the upper esophageal sphincter (UES) to simulated or spontaneous gastroesophageal reflux have shown conflicting results. These discrepancies could result from uncontrolled influence of variables such as posture, volume, and velocity of distension. We characterized in humans the effec... | I'd call it Yes. The UES response to esophageal distension is affected by combined effects of posture (spatial orientation of the esophagus), physical properties, and volume of refluxate, as well as the magnitude and rate of increase in intraesophageal pressure. The UES response to esophageal distension can be predicte... |
24,933,491 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is hyperconnectivity a fundamental response to neurological disruption? | In the cognitive and clinical neurosciences, the past decade has been marked by dramatic growth in a literature examining brain "connectivity" using noninvasive methods. We offer a critical review of the blood oxygen level dependent functional MRI (BOLD fMRI) literature examining neural connectivity changes in neurolog... | This summary of the functional imaging literature using fMRI methods reveals that hyperconnectivity is a common response to neurological disruption and that it may be differentially observable across brain regions. We discuss the factors contributing to both hyper- and hypoconnectivity results after neurological disrup... |
18,031,394 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is tumor size associated with the systemic inflammatory response but not survival in patients... | To examine the relationship between tumor diameter, C-reactive protein concentrations and survival in patients undergoing surgery for colorectal cancer.
Tumor diameter and pathological characteristics of the resected specimen were assessed in 227 patients. Circulating concentrations of C-reactive protein were measured... | I'd call it Yes. Prior to surgery, the maximal tumor diameter is associated with an elevated preoperative C-reactive protein concentration but not survival in patients with primary operable colorectal cancer. |
16,156,893 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does aggregation as bacterial inclusion bodies imply inactivation of enzymes and fluorescent proteins? | Many enzymes of industrial interest are not in the market since they are bio-produced as bacterial inclusion bodies, believed to be biologically inert aggregates of insoluble protein.
By using two structurally and functionally different model enzymes and two fluorescent proteins we show that physiological aggregation ... | This observation offers promising possibilities for the exploration of inclusion bodies as catalysts for industrial purposes, without any previous protein-refolding step.
That leads me to No. |
21,836,085 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Do chronically epileptic human and rat neocortex display a similar resistance against spreading depolarization in vitro? | Experimental and clinical evidence suggests that prolonged spreading depolarizations (SDs) are a promising target for therapeutic intervention in stroke because they recruit tissue at risk into necrosis by protracted intracellular calcium surge and massive glutamate release. Unfortunately, unlike SDs in healthy tissue,... | Our results suggest that chronic epilepsy confers resistance against SD. This should be considered when human tissue is used for screening of neuroprotective drugs. The finding of similar potassium thresholds for SD in epileptic human and rat neocortex challenges previous speculations that the resistance of the human b... |
17,378,893 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is prognosis after unmanipulated HLA-haploidentical blood and marrow transplantation correlated to the numbers of KIR ligands in recipients? | The goal of this study was to explore the role of NK cell alloreaction in predicting prognosis under unmanipulated HLA-haploidentical blood and marrow transplantation and examine whether the presence of any individual donor-activating KIR gene had an influence on the clinical outcome.
We studied the HLA and KIR genoty... | These data indicate that prognosis after transplantation is associated with the numbers of KIR ligands in recipients and T-cell alloreaction may play a predominant role in this model.
That leads me to Yes. |
22,534,544 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does modest alcohol consumption have an inverse association with liver fat content? | Modest alcohol consumption has been suggested to be protective against alanine amino-transferase activities and ultrasonography-defined fat-ty liver. We aimed to explore the association between alcohol consumption and liver fat content as quantitative-ly determined by computed tomography (CT).
One-thousand two-hundred... | Conclusion Yes. Alcohol consumption has an inverse association with CT-determined liv-er fat content independent of metabolic syndrome factors, liver enzyme activities and physical activities. |
19,262,738 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveal an epig... | Increasing evidence implicates the critical roles of epigenetic regulation in cancer. Very recent reports indicate that global gene silencing in cancer is associated with specific epigenetic modifications. However, the relationship between epigenetic switches and more dynamic patterns of gene activation and repression ... | I'd call it Yes. This work offers a dynamic picture of epigenetic switches in carcinogenesis and contributes to an overall understanding of coordinated regulation of gene expression in cancer. Our data indicate an H3K4me3/H3K27me3 epigenetic signature of prostate carcinogenesis. |
21,298,510 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does sleep apnea determine soluble TNF-α receptor 2 response to massive weight loss? | The effects of surgical weight loss (WL) on inflammatory biomarkers associated with sleep apnea remain unknown. We sought to determine if any biomarkers can predict amelioration of sleep apnea achieved by bariatric surgery. We hypothesized that surgical WL would substantially reduce severity of sleep apnea and levels o... | I'd call it Yes. Of all the biomarkers, the decrease in sTNFαR2 was independently determined by the amelioration of sleep apnea achieved by bariatric surgery. The results suggest that sTNFαR2 may be a specific sleep apnea biomarker across a wide range of body weight. |
14,992,899 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does lung perfusion with protective solution relieve lung injury in corrections of Tetralogy of Fallot? | The aim of this study was to evaluate the protective effect of pulmonary perfusion with hypothermic protective solution on lung function after cardiopulmonary bypass in corrections of Tetralogy of Fallot.
Sixty-four consecutive children with Tetralogy of Fallot were randomly divided into a control group (n = 30) and a... | Lung perfusion with hypothermic protective solution during cardiopulmonary bypass relieved lung injury in corrections of Tetralogy of Fallot. The inhibition of lung vascular endothelial cell injury may be the major mechanism of relieving cardiopulmonary bypass-induced lung injury.
So overall I'd say Yes. |
26,095,288 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does lymphocyte activation gene 3 negatively regulate the function of intrahepatic hepatitis C virus-specifi... | Chronic hepatitis C (CHC) in humans caused by persistent hepatitis C virus (HCV) infection is a global public health problem. The functional exhaustion of HCV-specific CD8(+) T cells regulated by several inhibitory receptors has been shown to contribute to chronic HCV infection. Lymphocyte activation gene 3 (LAG-3), wh... | Conclusion Yes. LAG-3 negatively regulated the function of HCV-specific CD8(+) T cells in CHC patients. |
27,166,702 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is prenatal exposure to multiple pesticides associated with auditory brainstem response at 9m... | Pesticides are associated with poorer neurodevelopmental outcomes, but little is known about the effects on sensory functioning.
Auditory brainstem response (ABR) and pesticide data were available for 27 healthy, full-term 9-month-old infants participating in a larger study of early iron deficiency and neurodevelopmen... | I'd call it Yes. ABR processing was slower in infants with greater prenatal pesticide exposure, indicating impaired neuromaturation. Infants with lower cord blood ferritin appeared to be more sensitive to the effects of prenatal pesticide exposure on ABR latency delay, suggesting an additive or multiplicative effect. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.