pubid int32 1.41M 27.9M | instruction stringlengths 202 533 | input stringlengths 66 4.17k | output stringlengths 33 958 |
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24,445,033 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does alcohol use and positive screening result for depression and anxiety are highly prevalent among Chinese children with strabismus? | To study associations between strabismus and alcohol use, anxiety, and depression among 10- to 17-year-old children in Guangdong, southern China.
Cross-sectional, population-based study.
Among 7537 children aged 6-17 years from 9 randomly selected primary and middle schools, ocular alignment was assessed with the Hir... | These Chinese children with strabismus had a significantly higher prevalence of alcohol use and possible markers of emotional problems than children without strabismus. Further research should focus on the appropriateness of classifying surgical treatment for strabismus as "cosmetic" (ineligible for reimbursement) unde... |
24,784,037 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is serum uric acid concentration linked to wearing-off fluctuation in Japanese Parkinson 's disease patients? | Serum uric acid (UA) concentration is linked to the risk of progression of Parkinson's disease (PD).
The aim of this study was to examine the association between serum UA concentration and the occurrence of wearing-off fluctuation (WOF) in Japanese PD patients.
A total of 123 Japanese patients with PD were enrolled i... | Our results showed that serum UA concentration was associated with the occurrence of WOF. Serum UA concentration may be a predictive factor for WOF.
That leads me to Yes. |
20,159,393 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is pelvic examination unnecessary in pregnant patients with a normal bedside ultrasound? | This study examines the necessity of a formal pelvic examination in patients with early pregnancy-related complaints and an intrauterine pregnancy on bedside ultrasound (US).
Data were prospectively collected on emergency department (ED) patients presenting with early pregnancy complaints and bedside US evidence of in... | In patients with a US-documented viable pregnancy, the pelvic examination did not contribute to the patient's immediate obstetric treatment. Occult cervical pathogens may be present in these patients.
That leads me to Yes. |
15,712,232 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Are serum levels of phytanic acid associated with prostate cancer risk? | Recent findings of over-expression of the AMACR gene in prostate cancer and association between sequence variants in the AMACR gene and prostate cancer risk, along with the well established findings of association between prostate cancer risk and over-consumption of dairy products and red meat, indirectly suggest that ... | Conclusion Yes. Although the results from our study suggest phytanic acid levels may be associated with prostate cancer risk, they were based on a study with a small sample size. Much larger studies are required to confirm these important findings. |
16,810,127 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Do plasma HDL subfraction levels increase in rats fed proso-millet protein concentrate? | Millet has been consumed as human food in the countries of Asia and Africa. We reported previously the effects of dietary protein concentrates from proso millet (Panicum miliaceum L.) on plasma levels of high-density lipoprotein HDL cholesterol. Of note is that of these HDL subfractions, HDL2 particles may have the mor... | PMPC could have a beneficial effect on cardiovascular disease because HDL2 subfractions may have the more strongly protective effect against the risk of coronary heart disease.
So overall I'd say Yes. |
15,292,471 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does taurine alter respiratory gas exchange and nutrient metabolism in type 2 diabetic rats? | To assess the effect of taurine supplementation on respiratory gas exchange, which might reflect the improved metabolism of glucose and/or lipid in the type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
Male OLETF rats (16 weeks of age) were randomly divided into two groups: unsupplemented group and tauri... | Taurine supplementation may be an effective treatment for glucose intolerance and fat/lipid accumulation observed in type 2 diabetes associated with obesity. These metabolic changes might be ascribed, in part, to the alteration of circulating blood profiles, where the improved hyperglycemia and/or the blood accumulatio... |
25,521,664 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does novel SNP improve differential survivability and mortality in non-small cell lung cancer patients? | Non-small cell lung cancer (NSCLC) is a major cause of cancer-related death worldwide due to poor patient prognosis and clinical outcome. Here, we studied the genetic variations underlying NSCLC pathogenesis based on their association to patient outcome after gemcitabine therapy.
Bioinformatics analysis was used to in... | Conclusion Yes. The results suggest that POLA2+1747 GG/GA may be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis. |
22,381,828 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is acute normovolemic hemodilution safe in neurosurgery? | To determine the safety of acute normovolemic hemodilution (ANH) for patients undergoing neurosurgical procedures.
A group of 100 patients undergoing neurosurgical procedures was assigned prospectively to receive ANH. A group of 47 patients who underwent craniotomy for aneurysm clipping and standard anesthetic managem... | Conclusion Yes. ANH is a safe procedure for patients undergoing neurosurgical procedures. Further studies are necessary to confirm the improvement in brain oxygen extraction and the clinical impact. Nonetheless, patients undergoing aneurysm clipping with good clinical grades seem to profit from ANH. |
20,814,734 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does cytochrome P450 pathway contribute to methanandamide-induced vasorelaxation in rat aorta... | The generation of hyperpolarising vasorelaxant endothelial cytochrome P450 epoxygenase (CYP)-derived metabolites of arachidonic may provide beneficial effects for the treatment of cardiovascular diseases in which the bioavailability of NO is impaired. The cannabinoid methanandamide has vasodilatory properties linked to... | I'd call it Yes. Methanandamide endothelium-dependent vasorelaxation is mediated by CB(1) and CB(2) cannabinoid receptors. The NO- and CYP-mediated pathways contribute in a concurrent manner in this vascular effect. Stimulation of both cannabinoid receptor subtypes is indistinctly linked to NO or CYP routes to cause va... |
18,366,081 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Do noninvasive blood flow imaging for real-time feedback during laser therapy of port wine stain birthmarks? | During laser therapy of port wine stain (PWS) birthmarks, regions of persistent perfusion may exist. Immediate retreatment of such regions may improve PWS laser therapeutic outcome. To address this need, we propose use of laser speckle imaging (LSI) to provide real-time, quantitative feedback during laser surgery. Here... | Our results demonstrate the potential role of image-guided laser therapy of PWS birthmarks. LSI is a promising tool for noninvasive blood flow characterization during laser therapy due to its relative simplicity and low cost.
That leads me to Yes. |
23,166,823 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does helicobacter pylori colonization ameliorate glucose homeostasis in mice through a PPAR γ-dependent mechanism? | There is an inverse secular trend between the incidence of obesity and gastric colonization with Helicobacter pylori, a bacterium that can affect the secretion of gastric hormones that relate to energy homeostasis. H. pylori strains that carry the cag pathogenicity island (PAI) interact more intimately with gastric epi... | Gastric infection with some commensal strains of H. pylori ameliorates glucose homeostasis in mice through a PPAR γ-dependent mechanism and modulates macrophage and Treg cell infiltration into the abdominal white adipose tissue.
So overall I'd say Yes. |
16,936,149 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does c-peptide affect ocular blood flow in patients with type 1 diabetes? | The aim of the present study was to investigate the effect of intravenous C-peptide infusion on ocular blood flow in patients with type 1 diabetes under euglycemic conditions.
The study was performed in a randomized, placebo-controlled, double-masked, two-way, crossover design in 10 type 1 diabetic patients. C-peptide... | The data of the present study indicate that exogenous C-peptide exerts no effect on ocular hemodynamic parameters in type 1 diabetic patients under euglycemic conditions. The maximum detectable change in these parameters was <25%.
That leads me to No. |
17,545,674 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is high membrane transport status on peritoneal dialysis associated with reduced survival fol... | High transporter status is associated with reduced survival of patients receiving peritoneal dialysis (PD). This may be due primarily to the development of complications related to the PD process, in which case the survival disadvantage may not persist following transfer to haemodialysis (HD). In this study, we aimed t... | I'd call it No. The survival disadvantage associated with high peritoneal membrane transport status during PD treatment does not persist following transfer to HD. Early transfer to HD may be beneficial in this patient group. |
23,050,072 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is ethylene involved in maintaining tomato ( Solanum lycopersicum ) pollen quality under heat-stress conditi... | Exposure to higher-than-optimal temperatures reduces crop yield and quality, mainly due to sensitivity of developing pollen grains. The mechanisms maintaining high pollen quality under heat-stress conditions are poorly understood. Our recently published data indicate high heat-stress-induced expression of ethylene-resp... | Conclusion Yes. Ethylene plays a significant role in tomato pollen thermotolerance. Interfering with the ethylene signalling pathway or reducing ethylene levels increased tomato pollen sensitivity to heat stress, whereas increasing ethylene levels prior to heat-stress exposure increased pollen quality. |
20,655,044 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does long-term LDL-c lowering in heterozygous familial hypercholesterolemia normalize carotid intima-media t... | We investigated the effectiveness of statins in daily practice in reducing the arterial wall thicknesses by comparing the carotid intima-media thickness (cIMT) between statin-treated familial hypercholesterolemia (FH) patients and their unaffected spouses.
FH subjects treated with LDL-c lowering medication for at leas... | Conclusion Yes. Long-term statin treatment normalizes cIMT in severe FH patients and therefore it is likely that the extreme risk of cardiovascular disease in FH patients is significantly reduced by this therapy. |
19,691,826 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is control of chicken CR1 retrotransposons independent of Dicer-mediated RNA interference pat... | Dicer is an RNase III-ribonuclease that initiates the formation of small interfering RNAs as a defence against genomic parasites such as retrotransposons. Despite intensive characterization in mammalian species, the biological functions of Dicer in controlling retrotransposable elements of the non-mammalian vertebrate ... | I'd call it Yes. Our data provide evidence that chicken CR1 retrotransposons, unlike their mammalian L1 counterparts, do not undergo retrotransposition because most CR1 retrotransposons are truncated or mutated at their 5'UTR promoters and thus are not subjected to Dicer-mediated RNAi-silencing control. |
27,451,413 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is a dysregulation of glucose metabolism control associated with carotid atherosclerosis in patients with coronary heart disease ( CORDIOPREV-DIAB study )? | Patients with coexisting coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) are at high risk of cardiovascular recurrence, however, it is not well established whether they exhibit an increased intima-media thickness of both common carotid arteries (IMT-CC). Furthermore, whether this relationship is inhere... | Our results highlight the importance of properly controlling glucose metabolism in CHD patients, in younger populations in particular, providing an easy way of categorizing patients with an increased IMT-CC. Moreover, glucose concentration at 120 min could contribute to CVD risk and its determination could be used as a... |
11,284,764 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is rieger syndrome associated with PAX6 deletion? | Rieger syndrome is an autosomal dominant condition defined by anterior segment dysgenesis in combination with facial, dental, skeletal and umbilical abnormalities. To date Rieger syndrome has been associated with mutations in the PITX2 gene at chromosome 4q25 and a second locus has been found at chromosome 13q14.
We d... | Conclusion Yes. Rieger syndrome can -- in addition to PITX2 gene mutations and abnormalities at chromosome 13q14 -- be associated with PAX6 gene abnormalities. |
19,187,919 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Do relationship between right cervical vagus nerve stimulation and atrial fibrillation inducibility : therapeutic intensities increase arrhythmogenesis? | Strong vagus nerve stimulation (VNS) is routinely used to induce and maintain atrial fibrillation (AF) in acute animal studies. Taken as a surrogate of increased vagal tone, such observations suggest an arrhythmogenic role of VNS in AF. In contrast, VNS has been demonstrated to have profound therapeutic effects in hear... | AF inducibility by right cervical VNS is intensity dependent: strong VNS (producing > or =60% SCL prolongation) facilitates AF, while moderate VNS (producing < or =40% SCL prolongation) appears not to affect AF. The nonarrhythmogenic effect of therapeutic chronic VNS was further verified in conscious animals. We conclu... |
23,404,560 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does p53 immunohistochemical expression correlate with clinical features in 207 carcinomas of the oral cavit... | The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination.
Sections made from two tissu... | Conclusion No. Our failure in detecting any association of the p53 immunohistochemical expression regardless of HPV status with clinical features of these tumours suggests it lacks a prognostic value for squamous cell carcinomas of the oral cavity. |
14,726,547 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is wall shear stress associated with intima-media thickness and carotid atherosclerosis in subjects at low coronary heart disease risk? | Systemic and local coronary heart disease (CHD) risk factors participate in atherogenesis. The role of wall shear stress, a major local risk factor, remains to be elucidated.
Two hundred thirty-four subjects were carefully characterized for the presence of hypertension, hyperlipidemia, diabetes mellitus, obesity, and ... | In subjects traditionally considered at low CHD risk, intima-media thickening and carotid atherosclerosis are significantly associated with low wall shear stress. In contrast, in subjects at high CHD risk, the contribution of wall shear stress seems to be masked, and age becomes the only factor significantly associated... |
20,693,923 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does early administration of L-arginine in experimental acute spinal cord injury impair long-term motor function recovery? | Recently, we reported that L-arginine, a nitric oxide precursor, reverses altered drug disposition induced by acute spinal cord injury (SCI) by increasing hepatic blood flow, without affecting mean arterial pressure and heart rate, whereas others have shown that it produces neuroprotection in several models of acute ne... | L-arginine as used here interfered with the functional outcome of rats subjected to SCI, suggesting that L-arginine or its metabolic products may be neurotoxic. Because of its potential utility for acute SCI suggested in the past, strategies should be designed to block its apparent neurotoxicity.
So overall I'd say Ye... |
21,617,224 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does zeranol induce cell proliferation and protein disulfide isomerase expression in mammary gland of ACI ra... | Zeranol is a non-steroidal anabolic growth promoter with potent estrogenic activity that is widely used as a growth promoter in the US beef industry. Consumption of beef derived from Zeranol-implanted cattle may be a risk factor for breast cancer. Protein disulfide isomerase (PDI) has been studied extensively as a key ... | Conclusion Yes. These findings suggest that up-regulated expression of PDI may play a critical role in mammary tumorigenesis and cell proliferation in response to Zeranol. Our findings implicate PDI as a biomarker for mammary tumorigenesis. |
27,212,082 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does tGF-β1-induced PAI-1 contribute to a profibrotic network in patients with eosinophilic e... | Eosinophilic esophagitis (EoE) is an allergic disease of increasing worldwide incidence. Complications are due to tissue remodeling and involve TGF-β1-mediated fibrosis. Plasminogen activator inhibitor 1 (PAI-1/serpinE1) can be induced by TGF-β1, but its role in EoE is not known.
We sought to understand the expression... | I'd call it Yes. PAI-1 expression is significantly increased in the epithelium in patients with EoE and reflects fibrosis, and its inhibition decreases TGF-β1-induced gene expression. Epithelial PAI-1 might serve as a marker of EoE severity and form part of a TGF-β1-induced profibrotic network. |
22,940,580 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is identification and susceptibility testing of microorganism by direct inoculation from positive blood cult... | The objective of this study was to evaluate the reliability and accuracy of the combined use of MALDI-TOF MS bacterial identification and the Vitek-2 Compact antimicrobial susceptibility testing (AST) directly from positive blood cultures.
Direct identification by MALDI-TOF MS and AST were performed in parallel to the... | Conclusion Yes. We conclude that direct identification by MALDI-TOF and inoculation of Vitek-2 Compact AST with positive blood culture bottles yielded very good results and decreased time between initial inoculation of blood culture media and determination of the antibiotic susceptibility for Gram-negative rods and Gra... |
22,702,055 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Do [ MicroRNA-210 modified human umbilical vein endothelial cells induce capillary formation ]? | To construct human recombinant lentiviral expression vector of microRNA-210 (miR-210) and to explore the over-expression of miR-210 on the capillary formation in human umbilical vein endothelial cells 12 (HUVE-12).
The recombinant lentiviral expression vector of pGCSIL-green fluorescent protein (GFP)-pre-miR-210 was c... | The recombinant lentiviral expression vector of miR-210 is constructed successfully and HUVE-12 over-expressing miR-210 can significantly increase the capillary formation, which facilitates further study on the molecular functions of miR-210 in angiogenesis.
So overall I'd say Yes. |
27,378,611 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does a Health at Every Size intervention improve intuitive eating and diet quality in Canadian women? | Health at Every Size
The HAES
Women who participated in the HAES | The HAES
So overall I'd say Yes. |
23,862,688 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does lutein protect retinal pigment epithelium from cytotoxic oxidative stress? | Lutein (LUT) and zeaxanthin (ZEA) are currently under investigation in clinical trials as prophylactic nutritional agents for age-related macular degeneration (AMD). However, dose used in these trials is empirical and not been investigated in in vitro studies.
In this study, we investigated the dose-response effect of... | Conclusion Yes. Results from our study provide in vitro data to support the epidemiologic studies, which are currently underway to provide evidence that lutein may act as cofactor that modulates processes implicated in AMD pathogenesis. |
26,544,970 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does plasmid DNA Vaccine Co-Immunisation modulate Cellular and Humoral Immune Responses Induc... | An effective HIV vaccine will likely require induction of both mucosal and systemic cellular and humoral immune responses. We investigated whether intramuscular (IM) delivery of electroporated plasmid DNA vaccine and simultaneous protein vaccinations by intranasal (IN) and IM routes could be combined to induce mucosal ... | I'd call it Yes. These data suggest that while IN inoculation alone elicits both cellular and humoral responses, co-administration with homologous DNA vaccination can tailor these towards a more balanced Th1/Th2 phenotype modulating the cellular cytokine profile while eliciting high-levels of antigen-specific antibody.... |
8,445,108 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does glycolic acid peel for the treatment of wrinkles and photoaging? | Glycolic acid is an alpha hydroxyacid that is useful as a chemical peeling agent.
To discuss the techniques using glycolic acid to remove actinic keratoses, fine wrinkles, lentigines, melasma, and seborrheic keratoses.
Applied in a carefully timed manner, the depth of penetration can be titrated by the timed duration... | Conclusion Yes. We have found glycolic acid can be an ideal adjunct to other cosmetic modalities such as soft tissue augmentation. |
24,491,163 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is acute murine antigen-induced arthritis affected by disruption of osteoblastic glucocorticoid signalling? | The role of endogenous glucocorticoids (GC) in the initiation and maintenance of rheumatoid arthritis (RA) remains unclear. We demonstrated previously that disruption of GC signalling in osteoblasts results in a profound attenuation of K/BxN serum-induced arthritis, a mouse model of RA. To determine whether or not the ... | Acute murine AIA is not affected by a disruption in osteoblastic GC signalling. These data indicate that osteoblasts do not modulate the T cell-mediated inflammatory response via a GC-dependent pathway.
So overall I'd say No. |
23,810,537 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does spindle pole body history intrinsically link pole identity with asymmetric fate in budding yeast? | Budding yeast is a unique model for exploring differential fate in a cell dividing asymmetrically. In yeast, spindle orientation begins with the old spindle pole body (SPB) (from the preceding cell cycle) contacting the bud by its existing astral microtubules (aMTs) while the new pole delays astral microtubule organiza... | Spc72 differential recruitment imparting asymmetric aMT organization represents the most upstream determinant linking SPB historical identity and fate.
That leads me to Yes. |
23,992,161 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does intense pulsed light enhance transforming growth factor beta1/Smad3 signaling in acne-prone skin? | Recently, much interest has been generated in the use of intense pulsed light (IPL) sources in the treatment of various skin conditions. However, the underlying mechanism for its therapeutic action has not been elucidated.
To investigate the effect of IPL on the in vivo expression of transforming growth factor beta1 (... | Intense pulsed light upregulates TGF-β1/Smad3 signaling in perilesional skin obtained from patients with mild-to-moderate inflammatory acne vulgaris. Further experiments on lesional skin and downstream effects are warranted to determine whether it may play a role in IPL-induced resolution of acne vulgaris.
That leads ... |
10,689,007 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is pregnancy outcome affected by antiphospholipid antibody status in women referred for in vitro fertilization? | To determine the prevalence of antiphospholipid (aPL) and anti-beta 2 glycoprotein I (anti-beta2-GPI) antibodies in women referred for IVF and to prospectively evaluate the effect of these antibodies on IVF outcome.
Prospective observational study.
A university hospital and IVF unit.
Three hundred eighty consecutive... | Although women referred for IVF have a high prevalence of aPL, these antibodies do not affect the outcome of treatment. Screening women undergoing IVF for aPL is not justified.
So overall I'd say No. |
25,676,404 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does [ Nimotuzumab significantly enhance chemosensitivity of PC9 human lung adenocarcinoma cells to paclitax... | Nimotuzumab is a humanized IgG1 type monoclonal antibody targeting epidermal growth factor receptor, and can enhance chemosensitivity and radiosensitivity of certain cancers. The aim of this study is to investigate the effects of nimotuzumab on the chemosensitivities of PC9 human lung adenocarcinoma cells to common che... | Conclusion Yes. Nimotuzumab enhanced the chemosensitivity of PC9 cell to paclitaxel by enhancing G2/M arrest and aggregation of tublin and microfilaments. Therefore, Nimotuzumab combined with taxane drugs could be a potential effective regimen in non-small cell lung cancer. |
18,550,915 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does hypermethylation-modulated downregulation of claudin-7 expression promote the progression of colorectal carcinoma? | The expression of tight junction-related transmembrane protein claudin-7 (CLDN7) and its regulatory mechanism were investigated in colorectal carcinomas (CRCs).
Methylation-specific polymerase chain reaction and treatment with the demethylating agent 5-aza-2'-deoxycytidine were conducted to analyze the methylation sta... | These findings suggest that the CLDN7 gene silencing by promoter hypermethylation and the resultant reduction of CLDN7 expression may play an important role in the progression of CRCs.
So overall I'd say Yes. |
18,174,826 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does dopamine transporter genotype convey familial risk of attention-deficit/hyperactivity di... | The dopamine transporter (DAT1) gene has been implicated in attention-deficit/hyperactivity disorder (ADHD), although the mechanism by which it exerts its effects remains unknown. The polymorphism associated with ADHD has been shown to affect expression of the transporter in vitro and in vivo. Dopamine transporters are... | I'd call it Yes. These preliminary results suggest that the DAT1 gene effects in the striatum are involved in translating the genetic risk of ADHD into a neurobiological substrate. As such, this study represents a first step in elucidating the neurobiological mechanisms underlying genetic influences in ADHD. Furthermor... |
26,724,835 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is rhinitis in Swiss adults associated with asthma and early life factors , but not second hand tobacco smoke or obesity? | Second hand tobacco smoke (SHS) and overweight/obesity are risk factors for asthma and lower airway respiratory symptoms. We investigated whether SHS or overweight/obesity were also associated with allergic or non-allergic rhinitis.
Cross-sectional data were obtained during the second SAPALDIA Study. Interviewer admin... | Allergic and non-allergic rhinitis have different risk factors apart from asthma. There are significant regional variations within Switzerland, which are not explained by the factors examined.
So overall I'd say Yes. |
19,563,792 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is low catalase activity in blood associated with the diabetes caused by alloxan? | Hydrogen peroxide is enzymatically processed by catalase, and catalase deficiency in blood is known as acatalasemia. We examined whether low catalase activity is a risk factor for diabetes mellitus.
Blood glucose, insulin and glucose tolerance test were examined in acatalasemic and normal mice under non-stress and oxi... | Conclusion Yes. These results indicate that low catalase activity in the blood is associated with the diabetes mellitus caused by alloxan administration. |
24,759,440 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does peer passenger influence on male adolescent drivers ' visual scanning behavior during simulated driving... | There is a higher likelihood of crashes and fatalities when an adolescent drives with peer passengers, especially for male drivers and male passengers. Simulated driving of male adolescent drivers with male peer passengers was studied to examine passenger influences on distraction and inattention.
Male adolescents dro... | Conclusion Yes. The presence of a male peer passenger was associated with a reduction in the visual scanning range of male adolescent drivers. This reduction could be a result of potential cognitive load imposed on the driver due to the presence of a passenger and the real or perceived normative influences or expectati... |
23,948,974 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does the integrin inhibitor cilengitide affect meningioma cell motility and invasion? | Meningiomas are frequent intracranial or spinal neoplasms, which recur frequently and can show aggressive clinical behaviour. We elucidated the impact of the integrin inhibitor cilengitide on migration, proliferation, and radiosensitization of meningioma cells.
We analyzed integrin expression in tissue microarrays of ... | I'd call it Yes. These data show that a monotherapy with cilengitide is not likely to achieve major responses in rapidly growing malignant meningiomas, although brain invasion may be reduced because of the strong antimigratory properties of the drug. The combination with radiotherapy warrants further attention. |
22,382,396 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Do automated reminders decrease postoperative nausea and vomiting incidence in a general surgical population... | Guidelines to minimize the incidence of postoperative nausea and vomiting (PONV) have been implemented in many hospitals. In previous studies, we have demonstrated that guideline adherence is suboptimal and can be improved using decision support (DS). In this study, we investigate whether DS improves patient outcome th... | Conclusion Yes. Automated reminders can improve patient outcome by improving guideline adherence. |
16,525,855 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does blockade of muscarinic acetylcholine receptors in the ventral tegmental area prevent acquisition of food-rewarded operant responding in rats? | We recently found that muscarinic receptor (mAChR) stimulation in the ventral tegmental area (VTA) is involved in the acquisition of a feeding task.
To investigate the involvement of VTA mAChR and nicotinic receptors (nAChR) in the acquisition and performance of a food-rewarded lever-pressing task.
In experiment 1 (N... | Stimulation of VTA mAChR, but not of nAChR, is necessary for the acquisition of a food-rewarded lever-pressing task and neither is necessary for the performance of the task.
So overall I'd say Yes. |
17,552,313 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does interaction with an immersive virtual environment correct users ' distance estimates? | Two experiments examined whether prior interaction within an immersive virtual environment (VE) enabled people to improve the accuracy of their distance judgments and whether an improved ability to estimate distance generalized to other means of estimating distances.
Prior literature has consistently found that users ... | This finding limits the generality of the underestimation effect in VEs and suggests that distance underestimation in VEs may not be a road block to the development of VE applications.
That leads me to Yes. |
24,199,632 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is axis-I comorbidity linked to prospective instability of diagnoses within eating disorders? | Eating disorders (ED) are classified into Anorexia Nervosa, Bulimia Nervosa, and eating disorder not otherwise specified. Prospectively, the diagnostic instability within ED is high, but it is not clear which factors may account for this instability. So far, there is no evidence of whether psychiatric comorbidity may p... | Conclusion Yes. Following previous reports of diagnostic crossover in ED, the present investigation points to an influence of a life-time psychiatric comorbidity, in particular of axis I, on follow-up diagnoses of ED. Comorbid affective disorders like major depression might facilitate a switching between clinical pheno... |
19,673,719 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is intrabdominal fat related to metabolic risk factors in Hispanic Americans , African Americans and in girls? | This study aimed to test the association of individual adipose depots on cardiometabolic outcomes, whether the association varied by depot and if the associations differed by race/ethnicity or gender in early pubertal children.
Three hundred and twenty children (53% male) aged 7-12 years self-identified as African Ame... | IAAT is uniquely related to metabolic risk factors in Hispanic Americans, African Americans and girls, suggesting that either the threshold for adverse effects of IAAT is lower, or the IAAT metabolism differs in these groups.
So overall I'd say Yes. |
20,643,202 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does curcumin attenuate allergic airway inflammation and hyper-responsiveness in mice through... | Curcumin, a polyphenol compound from Curcuma longa L. has been used for centuries as an anti-inflammatory remedy including asthma. Curcumin has been reported to exert an anti-inflammatory effect, in part, through inhibition of the NF-κB pathway.
The purposes of this study were to determine whether curcumin inhibits NF... | I'd call it Yes. Curcumin attenuates the development of allergic airway inflammation and hyper-responsiveness, possibly through inhibition of NF-κB activation in the asthmatic lung tissue. Our results indicate that curcumin may attenuate development of asthma by inhibition of NF-κB activation. |
22,957,985 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is dyspepsia strongly associated with major depression and generalised anxiety disorder - a community study? | The relationship between dyspepsia and psychiatric comorbidity such as anxiety and depression is poorly defined. Previous studies have been limited by lack of standardised diagnostic criteria.
To examine the prevalence and comorbidity of dyspepsia as defined by Rome III (6-month duration) with DSM-IV-TR generalised an... | With stringently adopted Rome III and DSM-IV-TR criteria, dyspepsia was strongly associated and often coincident in onset with generalised anxiety disorder and major depressive episodes in the community. Excessive healthcare utilisation should alert clinicians to risk of psychiatric comorbidity.
That leads me to Yes. |
21,791,104 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is the ColRS system essential for the hunger response of glucose-growing Pseudomonas putida? | The survival of bacteria largely depends on signaling systems that coordinate cell responses to environmental cues. Previous studies on the two-component ColRS signal system in Pseudomonas putida revealed a peculiar subpopulation lysis phenotype of colR mutant that grows on solid glucose medium. Here, we aimed to clari... | Conclusion Yes. We show that Pseudomonas putida growing on solid glucose medium adapts to glucose limitation through up-regulation of the sugar channel protein OprB1 that probably allows enhanced acquisition of a limiting nutrient. However, to survive such hunger response bacteria need signalling by the ColRS system. H... |
26,397,213 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is transient sacroiliac joint-related pain a common problem following lumbar decompressive surgery without instrumentation? | Patients with lumbar stenosis profit substantially from decompressive surgery. The change of body position and walking behaviour after successful surgery might lead to changed force effects on the entire spine and on the sacroiliac joint (SIJ). We analyzed the incidence of postoperative SIJ-related pain.
The authors a... | The adaptation of a changed body posture and gait could lead to transient overload of the SIJ and surrounding myofascial structures. The patients should be informed about this possible condition to avoid uncertainty, discontent, unnecessary diagnostics and to induce a quick, specific treatment. Non-diagnosed sacroiliac... |
22,260,944 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does association of β-blocker exposure with outcomes in heart failure differ between African American and wh... | β-Blockers (BB) are a mainstay of heart failure (HF) treatment, yet there are inconclusive data regarding their efficacy in African American individuals.
We performed a retrospective study of insured patients who received care from a large health system who were hospitalized for HF between January 2000 and June 2008 a... | Conclusion Yes. BB appears to be 40-50% less effective in preventing death or hospitalization among African American patients with HF as compared with white individuals. Further study is needed to better understand BB effectiveness in African Americans with HF. |
17,940,120 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Are nonobese diabetic ( NOD ) mice congenic for a targeted deletion of 12/15-lipoxygenase protected from aut... | 12/15-lipoxygenase (12/15-LO), one of a family of fatty acid oxidoreductase enzymes, reacts with polyenoic fatty acids to produce proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic beta-cells. It enhances interleukin 12 production by macrophages, and several of its products induce apoptosis of ... | Conclusion Yes. These results suggest an important role for 12/15-LO in conferring susceptibility to autoimmune diabetes in NOD mice through its effects on macrophage recruitment or activation. |
20,979,940 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Are nutritional markers , not markers of bone turnover , related predictors of bone mineral density in chron... | this study evaluated the factors associated with bone mineral density (BMD) in chronic peritoneal dialysis (CPD) patients.
in this cross-sectional study in 91 stable CPD patients, BMD was measured using dual-energy X-ray absorptiometry. Markers of bone turnover (iPTH, osteocalcin, bone alkaline phosphatase, serum C-te... | Conclusion Yes. nutritional markers, not markers of bone turnover, are correlated predictors of BMD in CPD patients. |
24,037,102 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is the vessels within epithelial circle ( VEC ) pattern as visualized by magnifying endoscopy... | Pathological studies indicate papillary adenocarcinomas are more aggressive than tubular adenocarcinomas, but a definitive diagnosis is difficult using conventional endoscopy alone. The vessels within an epithelial circle (VEC) pattern, visualized using magnifying endoscopy with narrow-band imaging (ME-NBI), may be a f... | I'd call it Yes. The VEC pattern as visualized using ME-NBI is a promising preoperative diagnostic marker of papillary adenocarcinoma. Coexisting undifferentiated carcinoma and submucosal invasion were each seen in approximately one fourth of VEC-positive cancers. |
10,421,601 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does matrix metalloproteinase inhibitor prevent acute lung injury after cardiopulmonary bypass? | Acute lung injury (ALI) after cardiopulmonary bypass (CPB) results from sequential priming and activation of neutrophils. Activated neutrophils release neutral serine, elastase, and matrix metalloproteinases (MMPs) and oxygen radical species, which damage alveolar-capillary basement membranes and the extracellular matr... | All pathological changes typical of ALI after CPB were prevented by CMT-3. Prevention of lung dysfunction followed an attenuation of both elastase and MMP-2 activity. This study suggests that strategies to combat ARDS should target terminal neutrophil effectors.
That leads me to Yes. |
27,054,196 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is fitness Level Associated with Sex-Specific Regional Fat Differences in Normal Weight Young Adults? | To characterize regional body composition and insulin sensitivity differences between young adults who were normal weight with either high or low fitness determined by VO
A cross-sectional comparison of normal weight males and females with high or low fitness matched on age and sex.
A total of 38 (20M/18F) individual... | Conclusion Yes. Higher fitness does not influence VAT in normal weight individuals. Sex influenced regional fat and insulin sensitivity differences between high fitness and low fitness groups. |
26,095,425 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is c-reactive protein measurement associated with an improved management of acute cholecystitis : a plié for a change? | The diagnosis of acute cholecystitis (AC) is challenging and may result in a delay in surgical treatment and increased mortality. The 2007 and 2013 Tokyo Guidelines for AC proposed to use C-reactive protein (CRP) as an additional bench mark of AC. The aim of this study was to evaluate whether CRP measurement influences... | CRP measurement does not influence management of patients with AC. To improve quality of care and to minimize health care provider costs physiologically fit patients with more advanced forms of AC and higher values of CRP should have their operation performed earlier than patients with mild AC and a lower concentration... |
27,400,789 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Do human iPSCs Differentiate Into Functional MSCs and Repair Bone Defects? | : Mesenchymal stem cells (MSCs) are currently the most established cells for skeletal tissue engineering and regeneration; however, their availability and capability of self-renewal are limited. Recent discoveries of somatic cell reprogramming may be used to overcome these challenges. We hypothesized that induced pluri... | Mesenchymal stem cells (MSCs) are currently the most established cells for skeletal tissue engineering and regeneration of various skeletal conditions; however, availability of autologous MSCs is very limited. This study demonstrates a new method to differentiate human fibroblast-derived induced pluripotent stem cells ... |
23,838,710 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is acute normovolemic hemodilution in the pig associated with renal tissue edema , impaired r... | The authors investigated the impact of acute normovolemic hemodilution (ANH) on intrarenal oxygenation and its functional short-term consequences in pigs.
Renal microvascular oxygenation (µPO2) was measured in cortex, outer and inner medulla via three implanted optical fibers by oxygen-dependent quenching of phosphore... | I'd call it Yes. ANH to a hematocrit of 15% statistically significantly impaired µPO2 and renal function in the crystalloid group. Less tissue edema formation and an unimpaired renal µPO2 in the colloid group might account for a preserved renal function. |
22,070,936 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is carotid endarterectomy in the acute phase of stroke-in-evolution safe and effective in selected patients? | This study documented with independent neurologic assessment the 30-day and 90-day outcomes in selected patients with severe internal carotid artery (ICA) stenosis who underwent carotid endarterectomy (CEA) in the acute phase of stroke-in-evolution (SIE).
From January 2003 to December 2010, data from patients who had ... | Conclusion Yes. This short series demonstrates that CEA in the acute phase of SIE with strict selection criteria and close blood pressure monitoring is safe, even after recent thrombolytic therapy, and is effective in functional outcome at 3 months. Larger series of patients are required to confirm the safety and effic... |
19,075,196 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Do phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia? | Vascular calcification (VC) is commonly seen in patients with chronic kidney disease (CKD). Elevated levels of phosphate and parathormone (PTH) are considered nontraditional risk factors for VC. It has been shown that, in vitro, phosphate transforms vascular smooth muscle cells (VSMCs) into calcifying cells, evidenced ... | Conclusion Yes. Phosphate, by itself is a potential pathogenic factor for VC. It is of note that phosphate overload, even without VC, was associated with overexpression of Runx2 in VSMCs. The mineral imbalance often seen in patients with CKD should be corrected. |
24,618,100 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does paroxetine ameliorate lipopolysaccharide-induced microglia activation via differential regulation of MA... | Paroxetine, a selective serotonin reuptake inhibitor for counteracting depression, has been recently suggested as having a role in prevention of dopaminergic neuronal degeneration in substantia nigra, a hallmark of Parkinson's disease (PD). The pathogenesis of this type of neurological disorders often involves the acti... | Conclusion Yes. Paroxetine inhibits LPS-stimulated microglia activation through collective regulation of JNK1/2 and ERK1/2 signaling. Our results indicate a potential role of paroxetine in neuroprotection via its anti-neuroinflammatory effect besides targeting for depression. |
25,299,387 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does f-spondin inhibit differentiation of clastic precursors via lipoprotein receptor-related protein 8 ( LRP8 )? | F-spondin, known to be a secreted neuronal glycoprotein, is highly expressed on the tooth root surface. The authors previously reported that F-spondin is one of the specific markers of cementoblasts in periodontal tissue. In chronic periodontitis, significant cemental resorption rarely occurs on the root side, although... | These findings indicate that secretory factors from F-spondin-expressing cells, including F-spondin, downregulate differentiation of clastic precursors. Moreover, F-spondin inhibits RANKL-mediated differentiation of clastic cells partially via LRP8. It is suggested that secretory F-spondin may act protectively from cem... |
21,155,094 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is infectious Chlamydia pneumoniae associated with elevated interleukin-8 and airway neutroph... | Neutrophilic asthma is thought to be less responsive than eosinophilic asthma to anti-inflammatory therapies including corticosteroids. Chlamydia pneumoniae has been implicated in asthma, possibly by induction of interleukin (IL-8). We hypothesized that IL-8 is increased in the bronchoalveolar lavage (BAL) fluid from c... | I'd call it Yes. Children with asthma who were PCR-positive for C. pneumoniae demonstrated elevated concentrations of IL-8 and neutrophils in BAL fluid compared with similar patients who were positive for C. trachomatis or Mycoplasma organisms, but PCR-negative for C. pneumoniae. Undiagnosed C. pneumoniae infection in ... |
19,557,603 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does static magnetic field attenuate mortality rate of mice by increasing the production of IL-1 receptor antagonist? | Disseminated intravascular coagulation (DIC) is a complex systemic thrombohemorrhagic disorder involving intravascular coagulation and hemorrhage. The aim of this study is to test whether static magnetic field (SMF) is effective in attenuating lipopolysaccharide (LPS)-induced DIC.
In vivo experiments were performed in... | Exposure to an SMF increases the plasma levels of IL-1ra. This effect may inhibit the reduction in PLT in plasma, resulting in prevention in LPS induced DIC.
So overall I'd say Yes. |
8,217,179 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does midazolam pretreatment ameliorate myoglobinemia or the clinical side effects of succinylcholine? | To determine whether the levels of serum myoglobin and the occurrence of fasciculations and postoperative symptoms following a single dose of succinylcholine are modified by the prior administration of midazolam.
Randomized, double-blind, placebo-controlled study.
Outpatient surgical service of a university hospital.... | Midazolam had no effect on myoglobin level or postoperative symptoms following succinylcholine.
So overall I'd say No. |
25,981,893 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is type 1 diabetes associated with an increased prevalence of hepatic steatosis? | Non-alcoholic fatty liver disease (NAFLD) is commonly associated with Type 2 diabetes. Recently, it has been suggested that NAFLD is also frequently associated with Type 1 diabetes and diabetic complications. In this study, we set out to determine whether Type 1 diabetes was associated with liver fat content measured u... | Our data showed that Type 1 diabetes was not associated with an increased prevalence of steatosis. Moreover, our study provided no specific arguments concerning a link between liver fat content and diabetic complications in patients with Type 1 diabetes.
That leads me to No. |
19,078,785 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Are parotid gland injections of botulinum toxin a effective in treating sialorrhea in amyotrophic lateral sclerosis? | : The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis.
: Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A.
: No adverse ... | : Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.
That leads me to Yes. |
11,889,443 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Is hypertension an independent predictor of delayed graft function and worse renal function only in kidneys with chronic pathological lesions? | Delayed graft function (DGF) has been identified as one of the principal correlates of poor graft survival in cadaveric renal transplantation. However, its risk factors and clinical predictors have been poorly elucidated.
We analyzed the risk factors of DGF with a specific emphasis on the role of histological damage o... | Our findings suggest that the quality of the transplanted organ and the occurrence of DGF are strictly related to each other and can influence graft function through apparently nonimmune mechanisms. In addition, long-standing donor hypertension is a strong independent variable affecting both DGF and graft function of s... |
19,208,366 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does up-regulation of anterior cingulate cortex NR2B receptors contribute to visceral pain re... | Electrophysiologic and behavioral studies have shown that increased N-methyl-D-aspartate (NMDA)-receptor activation of anterior cingulate cortex (ACC) neurons has a critical role in modulating visceral pain responses in viscerally hypersensitive (VH) rats. This study aimed to identify the NMDA receptor subtypes in peri... | I'd call it Yes. The NR2B subunit of the NMDA receptor has a critical role in the modulation of ACC sensitization and visceral pain responses in VH rats. |
23,906,664 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is gATA-3 down-regulated in patients with clear cell renal carcinoma? | GATA-3 is a transcription factor involved in human growth and development. Recent studies found its association with breast cancer, however, its expression profile in renal cell carcinoma (RCC) has not been investigated.
The study included 35 patients submitted to radical nephrectomy with confirmed pathological diagno... | Conclusion Yes. In summary, our present study clarifies that the aberrant expression profile of GATA-3 in human RCC is possibly involved with tumorigenesis, and the complicated mechanism is worthy of further investigation. |
25,012,536 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Are β-catenin ( CTNNB1 ) mutations associated with prognosis in advanced hepatocellular carcinoma? | Mutation of the exon 3 of CTNNB1, the coding gene of β-catenin, is a crucial molecular mechanism leading to aberrant activation of the Wnt/β-catenin pathway, which is highly associated with the carcinogenesis of hepatocellular carcinoma (HCC). The prevalence and clinical significance of CTNNB1 mutations in advanced HCC... | Conclusion No. In patients with advanced HCC, CTNNB1 mutations were not prognostically significant. No apparent increase of CTNNB1 mutations occurred during the progression of HCC. |
19,339,276 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does prognostic significance of p53 codon 72 polymorphism differ with race in colorectal adenocarcinoma? | Several studies have examined the prognostic value of the codon 72 polymorphism of the p53 gene in colorectal adenocarcinoma, but none have addressed patient race/ethnicity. Therefore, this study assessed the prognostic value of this polymorphism in African American and Caucasian colorectal adenocarcinoma patients sepa... | Conclusion Yes. The higher frequency of the Pro/Pro phenotype of p53 in African American patients with colorectal adenocarcinoma is associated with an increased incidence of p53 mutations, with advanced tumor stage, and with short survival. |
12,569,601 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Are overexpression of Glut-1 and increased glucose metabolism in tumors associated with a poor prognosis in patients with oral squamous cell carcinoma? | The overexpression of glucose transporters, especially of Glut-1, is a common characteristic of human malignancies, including head and neck carcinoma. Recently, the assessment of glucose metabolism in the tumor with [(18)F]-2-fluoro-2 deoxy-D-glucose (FDG) and positron emission tomography (FDG-PET) has been used to ide... | Both glucose transport and glucose metabolism determine the glycolytic tumor phenotype, which is a significant negative biomarker of prognosis and overall survival in patients with OSCC.
That leads me to Yes. |
23,915,292 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is early increase in serum-COMP associated with joint damage progression over the first five years in patien... | Currently available biomarkers for the early tissue process leading to joint damage in rheumatoid arthritis are insufficient and lack prognostic accuracy, possibly a result of variable activity of the disease over time. This study represents a novel approach to detect an altered activity of the disease process detected... | Conclusion Yes. Increasing serum-COMP levels between diagnosis and the subsequent 3 months in patients with early RA represents a novel indicator of an activated destructive process in the joint and is a promising tool to identify patients with significant joint damage progression during a 5-year period. |
27,318,994 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does physiological correlate to spontaneous physical activity variability in obese patients w... | Physical activity is promoted in patients with sleep disorders and obesity. The aim of the present study was to assess physiological factors influencing objectively measured spontaneous physical activity in already treated patients for obstructive sleep apnea (OSA) by nocturnal continuous positive airway pressure (CPAP... | I'd call it Yes. In severe obese patients with OSA, exercise capacity, ventilatory requirement, and dyspnea perception were main physiological components of physical activity. These results emphasize the need to consider specific training interventions that increase ability to perform intense physical activity in obese... |
20,303,708 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Do visual feedback and weight reduction of a grip strength dynamometer increase reliability in healthy child... | Test-retest reliability study on grip strength in children.
Measuring grip strength in children is difficult because of the weight and size of the instrument, brief attention span, and possible lack of task understanding. Therefore, adaptations to the measurement protocols to improve reliability would be very importan... | Conclusion No. No statistically significant difference was found among the reliability of the different protocols, but the suspension protocol produced small but significantly higher force levels. |
18,556,048 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does power quality affect teacher wellbeing and student behavior in three Minnesota Schools? | Poor power quality (dirty electricity) is ubiquitous especially in schools with fluorescent lights and computers. Previous studies have shown a relationship between power quality and student behavior/teacher health.
The purpose of this study is to determine the ability of power line filters to reduce dirty electricity... | Conclusion Yes. Dirty electricity in schools may be adversely affecting wellbeing of teachers and behavior of their students, especially younger students in middle and elementary school. Power line filters improve power quality and may also protect those who are sensitive to this energy. Work on electric and magnetic f... |
12,932,804 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is alexithymia in insulin-dependent diabetes mellitus related to depression and not to somatic variables or ... | To assess the prevalence of alexithymia in insulin-dependent diabetic mellitus (IDDM) outpatients. To examine whether alexithymia is associated with diabetic somatic variables, depression, and compliance.
Our sample comprised 69 diabetic outpatients followed in a university hospital. We assessed the prevalence of alex... | Conclusion Yes. In our sample, alexithymia was related to depression and not to somatic factors or compliance. |
27,154,002 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Is interleukin-25 detrimental for recovery after spinal cord injury in mice? | The cytokine, interleukin (IL)-25, is thought to be critically involved in inducing a type 2 immune response which may contribute to regeneration after central nervous system (CNS) trauma. We investigated whether applying recombinant IL-25, locally or systemically, in a mouse model of spinal cord injury (SCI) improves ... | I'd call it Yes. These data show for the first time that IL-25 is either ineffective when applied systemically or detrimental to spinal cord recovery when applied locally. Our findings question the potential neuroprotective role of IL-25 following CNS trauma. |
24,467,768 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is co-expression of HER3 and MUC1 associated with a favourable prognosis in patients with bladder cancer? | To investigate the functional impact of the interaction of MUC1 with the epidermal growth factor receptors HER3 and HER4 in patients with bladder cancer.
Using reverse transcription quantitative polymerase chain reaction, we examined MUC1 expression in 82 bladder cancer biopsies previously examined for the expression ... | Conclusion Yes. A high MUC1 expression was associated with a favourable prognosis in patients with bladder cancer when the expression of HER3 was also high. This suggests an involvement of HER3 in MUC1 function in bladder cancer. |
18,466,863 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does enteral glutamine supplementation impair intestinal blood flow in rats? | Clinical studies have shown that enteral immune-enhancing diets (IEDs) containing l-glutamine decrease septic complications and length of stay in some patient populations. Animal studies suggest IED benefits might include augmented gut blood flow. We hypothesized that enteral glutamine supplementation modulates gastroi... | Enteral glutamine supplementation (as in IEDs) appears to impair gastrointestinal blood flow. Because glutamine provides energy directly to active enterocytes, enteral glutamine availability might diminish metabolic stimuli of absorptive hyperemia. This finding might partially explain the benefits observed with parente... |
15,228,563 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does prospective cohort study of definite spider bite in Australian children? | To describe the clinical effects of spider bites in a paediatric population and compare to bites in an adult population.
Prospective follow up study of children with definite spider bites where the spiders were immediately collected and expertly identified. Cases were recruited from Australian emergency departments an... | Paediatric spider bite causes minor effects in the majority of cases, and is unlikely to cause necrotic ulcers, allergic reactions or infection. The severity and duration of effects differ from adults.
So overall I'd say Yes. |
12,557,146 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does gastric electrical stimulation with short pulses reduce vomiting but not dysrhythmias in... | The aim of this study was to investigate the acute effects of 3 different methods of electrical stimulation in the prevention of vasopressin-induced emetic response and gastric dysrhythmias.
Seven female hound dogs chronically implanted with 4 pairs of electrodes on gastric serosa were used in a 5-session study. Salin... | I'd call it Yes. Long-pulse stimulation normalizes vasopressin-induced slow wave abnormalities with no improvement in vomiting and behaviors suggestive of nausea. Short-pulse stimulation and electroacupuncture prevent vomiting and behaviors suggestive of nausea induced by vasopressin but have no effects on slow waves, ... |
21,739,003 | Below are abstracts and a yes/no-style research question. Synthesize what they imply and respond with your judgment (yes, no, or maybe) plus reasoning.
Question: Does 3D didactic model and useful guide of the semicircular conduct? | Knowledge of the anatomy and physiology of the semicircular canals and their central pathways is essential for the diagnosis of vestibular pathology. This 3 dimensional (3D) scheme of the Semicircular Canals (SSCC) is a teaching tool and a useful reference guide for rapid consultation.
A multicolored cardboard model i... | This 3 dimensional (3D) model of the Semicircular Canals (SSCC) is a practical, low cost tool for use in private and academic settings.
So overall I'd say Yes. |
21,666,393 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does electronic memorandum decrease unnecessary antimicrobial use for asymptomatic bacteriuria and culture-negative pyuria? | Asymptomatic bacteriuria/candidiuria (ASB) and culture-negative pyuria (CNP) are common and often result in inappropriate antibiotic use. We aimed to evaluate whether a standardized educational memorandum could reduce antimicrobial utilization for ASB/CNP.
Quasi-experimental study with a control group, from a convenie... | ASB and CNP resulted in antimicrobial exposure in more than one-quarter of our study patients. Placing a standardized memorandum in the electronic record was associated with a 65% relative reduction in antimicrobial-days for ASB and CNP.
That leads me to Yes. |
18,161,924 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does acanthus ilicifolius plant extract prevent DNA alterations in a transplantable Ehrlich ascites carcinom... | To investigate the chemopreventive efficacy of the Indian medicinal plant Acanthus ilicifolius L Acanthaceae in a transplantable Ehrlich ascites carcinoma (EAC)-bearing murine model.
Male Swiss albino mice were divided into four groups: Group A was the untreated normal control; Group B was the EAC control mice group t... | Conclusion Yes. Our data indicate that, ALE is beneficial in restoring haematological and hepatic histological profiles and in lengthening the survival of the animals against the proliferation of ascites tumour in vivo. Finally, the chemopreventive efficacy of the ALE is manifested in limiting MT expression and in prev... |
9,721,161 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does helicobacter pylori infection induce gastric cancer in mongolian gerbils? | Although epidemiological studies have indicated that Helicobacter pylori infection plays a crucial role in gastric carcinogenesis in humans, there is no direct proof that H. pylori is actually associated with gastric carcinogenesis. The purpose of this study was to elucidate the relationship between H. pylori infection... | We have successfully demonstrated that long-term infection with H. pylori induces adenocarcinoma in Mongolian gerbils. The observations are thus highly suggestive of the involvement of H. pylori infection in gastric carcinogenesis in humans.
That leads me to Yes. |
26,803,534 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does myxoma Virus induce Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells? | Multiple myeloma is a clonal malignancy of plasma B cells. Although recent advances have improved overall prognosis, virtually all myeloma patients still succumb to relapsing disease. Therefore, novel therapies to treat this disease remain urgently needed. We have recently shown that treatment of human multiple myeloma... | I'd call it Yes. Taken together, these results suggest that myxoma virus eliminates human multiple myeloma cells through a pathway unique to oncolytic poxviruses, making it an excellent therapeutic option for the treatment of relapsed or refractory patients. |
27,079,877 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does an Intronic Flk1 Enhancer direct Arterial-Specific Expression via RBPJ-Mediated Venous Repression? | The vascular endothelial growth factor (VEGF) receptor Flk1 is essential for vascular development, but the signaling and transcriptional pathways by which its expression is regulated in endothelial cells remain unclear. Although previous studies have identified 2 Flk1 regulatory enhancers, these are dispensable for Flk... | This study demonstrates a novel mechanism of arterial-venous identity acquisition, indicates a direct link between the Notch and VEGF signaling pathways, and illustrates how cis-regulatory diversity permits differential expression outcomes from a limited repertoire of transcriptional regulators.
That leads me to Yes. |
23,201,704 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Does metabolomic phenotyping validate the infant rhesus monkey as a model of human infant metabolism? | Rhesus macaque monkeys are widely used as models for human physiology and behavior. They are particularly suited for studies on infant nutrition and metabolism; however, few studies have directly compared their metabolic or microbiological phenotypes. The aim of the present study was to compare the metabolomic profiles... | Conclusion Yes. Comparison of the milk microbiome and urine, serum, and milk metabolome of rhesus macaques and humans has revealed substantial similarities that provide unique biological information highlighting the significance of rhesus macaques as a model for infant nutrition and developmental research. |
23,732,361 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does iL6 trans-signaling promote functional recovery of hypofunctional phagocytes through STAT3 activation during peritonitis? | The role of high interleukin 6 (IL6) levels has not been clearly explained in severe sepsis. We show that the augmentation of the IL6 signal by recombinant IL6 receptors (rIL6R) delivery allows the functional recovery of phagocytes in a peritonitis mouse model.
Mice were challenged intraperitoneally (i.p.) with live S... | These results indicate that augmentation of IL6 signaling appears to be critical for the effective management of hypofunctional neutrophils during severe inflammation, such as sepsis.
That leads me to Yes. |
24,353,624 | You are a biomedical assistant. Read the abstracts and the question below. Give a supported conclusion (yes, no, or maybe if the evidence is mixed or unclear) and a short explanation tied to the text.
Question: Is xPG a novel biomarker of clinical outcome in advanced non-small-cell lung cancer? | Polymorphisms in XPG were considered to contribute to the clinical outcome of patients receiving platinum drug chemotherapy. We investigated the impact of several potential SNPs of XPG on the efficacy of platinum-based chemotherapy in NSCLC patients.
A total of 433 patients were consecutively selected between Nov. 200... | Conclusion Yes. Our study suggests rs2296147 CT+TT and rs2094258 AG+GG genotypes contribute to the better survival of NSCLC. Our study provides significant information on role of prognostic value of XPG SNPs, and detecting of XPG could be used as predictive markers toward individualizing NSCLC treatment strategies. |
18,509,277 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Are melatonin secretion and non-specific immune responses differentially expressed in corticotropin-dependent and corticotropin-independent Cushing 's syndrome? | This study was done to clarify the relation between melatonin secretion and the hypothalamic-pituitary-adrenal axis.
In this clinical study using a follow-up approach, we investigated the circadian melatonin secretion and immune parameters of patients with corticotropin-dependent (Cushing's disease) and corticotropin-... | Our results demonstrate a specific mode of melatonin secretion and different nonspecific immune responses in the 2 investigated forms of hypercortisolism, specifically, corticotropin-dependent and corticotropin-independent Cushing's syndrome.
That leads me to Yes. |
12,826,229 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Does fas siRNA reduce apoptotic cell death of allogeneic-transplanted hepatocytes in mouse spleen? | Synthetic siRNAs 21 to 23 nucleotides in length silence gene expression posttranscriptionally, and RNA interference targeting Fas protects mice from fulminant hepatitis. Fas-mediated apoptosis has also been implied in the mechanism of hepatocyte apoptosis upon allogenic hepatocyte transplantation (HTx), and blockade of... | Fas silencing by RNA interference reduces apoptosis and increases survival of allogenic transplanted hepatocytes, and thus holds promise to inhibit acute rejection after hepatocyte transplantation.
That leads me to Yes. |
26,949,741 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Do electrocardiographic Markers and the Left Ventricular Ejection Fraction have Cumulative Effects on Risk of Sudden Cardiac Death? | To assess potential improvement in SCD risk prediction by adding selected risk markers from the 12-lead ECG to measurement of the left ventricular ejection fraction (LVEF).
Novel strategies to improve risk stratification for sudden cardiac death (SCD) are needed. Given the modest odds associated with most individual r... | Combining selected 12-lead ECG markers with LVEF improves SCD risk prediction, and warrants further investigation in prospective studies.
That leads me to Yes. |
14,981,898 | Answer the research question based solely on the provided abstracts. If the abstracts support it, say yes; if they contradict it, say no; if they are insufficient or ambiguous, say maybe. Explain in a few sentences.
Question: Does suppression of cystine uptake by sulfasalazine inhibit proliferation of human mammary ca... | Malignant progression of lymphoma cells is associated with acquisition of the cystine/glutamate antiporter, xc-, enhancing cystine uptake. Recently, we showed that sulfasalazine (SASP) is a specific xc- inhibitor. Here, we investigated xc- in mammary cancer cell lines.
Expression and function of xc- were evaluated by ... | I'd call it Yes. The results suggest: (i) malignant progression of human mammary cancer may be associated with acquisition of xc- expression potentially leading to increased growth autonomy and drug resistance, (ii) xc- may act as a therapeutic target. |
25,492,725 | Using only the evidence in the following abstracts, address the biomedical question. Include whether you conclude yes, no, or maybe, and briefly why.
Is male Gender independently associated with pulmonary tuberculosis among sputum and non-sputum producers people with presumptive tuberculosis in Southwestern Uganda? | Little is known about the association between gender and risk of TB infection. We sought to assess the impact of gender on TB prevalence among people with presumptive tuberculosis at a regional referral hospital in a high TB and HIV prevalence setting.
We analyzed data from two diagnostic TB studies conducted in rural... | In Southwestern Uganda, TB prevalence is higher among male than female people with presumptive TB. The increased risk of TB among males is independent of other TB risk factors. These findings emphasize the need for gender-focused interventions aimed at reducing TB transmission.
That leads me to Yes. |
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