conversations listlengths 2 2 |
|---|
[
{
"from": "human",
"value": "Question: Does treatment with egg antigens of Schistosoma mansoni ameliorate experimental colitis in mice through a colonic T-cell-dependent mechanism?\nContext: {'contexts': ['Helminth-derived molecules are being identified as a new therapeutic approach for immune-mediated dise... |
[
{
"from": "human",
"value": "Question: Is abnormal left ventricular contractile response to exercise in the absence of obstructive coronary artery disease associated with resting left ventricular long-axis dysfunction?\nContext: {'contexts': ['The etiology of reduced left ventricular (LV) ejection fraction ... |
[
{
"from": "human",
"value": "Question: Is sleep efficiency ( but not sleep duration ) of healthy school-age children associated with grades in math and languages?\nContext: {'contexts': ['The objective of this study was to examine the associations between objective measures of sleep duration and sleep effic... |
[
{
"from": "human",
"value": "Question: Are vitamin D levels and bone turnover markers related to non-alcoholic fatty liver disease in severely obese patients?\nContext: {'contexts': ['Morbidly obese patients usually present vitamin D deficiency or secondary hyperparathyroidism. Low vitamin D levels have bee... |
[
{
"from": "human",
"value": "Question: Are outcomes of abdominal wall reconstruction with acellular dermal matrix affected by wound contamination?\nContext: {'contexts': ['The optimal type of mesh for complex abdominal wall reconstruction has not been elucidated. We hypothesized that AWRs using acellular de... |
[
{
"from": "human",
"value": "Question: Does airway pressure release ventilation reduce conducting airway micro-strain in lung injury?\nContext: {'contexts': ['Improper mechanical ventilation can exacerbate acute lung damage, causing a secondary ventilator-induced lung injury (VILI). We hypothesized that VIL... |
[
{
"from": "human",
"value": "Question: Do a simplified method of preventing implant hex drive from aspiration or accidental swallowing during stage two implant recovery?\nContext: {'contexts': ['To prevent accidental ingestion of implant hex dive.', \"Dental floss which is used to stabilize the hex drive is... |
[
{
"from": "human",
"value": "Question: Is late onset spinal motor neuronopathy caused by mutation in CHCHD10?\nContext: {'contexts': ['A study was undertaken to identify the responsible gene defect underlying late onset spinal motor neuronopathy (LOSMoN/SMAJ; Online Mendelian Inheritance in Man #615048), an... |
[
{
"from": "human",
"value": "Question: Does low perfusion index affect the difference in glucose level between capillary and venous blood?\nContext: {'contexts': ['In emergency cases, finger stick testing is primarily used to check the blood glucose value of patients since it takes longer to obtain the veno... |
[
{
"from": "human",
"value": "Question: Are multiple pathways responsible for anti-inflammatory and cardiovascular activities of Hordeum vulgare L?\nContext: {'contexts': ['Hordeum vulgare L. (HV or barley) is used by traditional healers to treat various inflammatory and cardiovascular diseases, without the ... |
[
{
"from": "human",
"value": "Question: Does [ ITF increase the transcriptional activity of ITF promoter via the JAK-STAT3 signal transduction pathway ]?\nContext: {'contexts': ['To investigate the eff ect of intestinal trefoil factor (ITF) on the transcriptional activity of ITF promoter and to explore the r... |
[
{
"from": "human",
"value": "Question: Does clinical evaluation of pazopanib eye drop versus ranibizumab intravitreal injections in subjects with neovascular age-related macular degeneration?\nContext: {'contexts': ['To evaluate pazopanib eye drops in subjects with active subfoveal choroidal neovascularizat... |
[
{
"from": "human",
"value": "Question: Does long-term treadmill exercise attenuate tau pathology in P301S tau transgenic mice?\nContext: {'contexts': [\"Recent epidemiological evidence suggests that modifying lifestyle by increasing physical activity could be a non-pharmacological approach to improving symp... |
[
{
"from": "human",
"value": "Question: Does alpha and beta EEG power reflect L-dopa acute administration in parkinsonian patients?\nContext: {'contexts': ['To evaluate the effect of an acute L-dopa administration on eye-closed resting state electroencephalographic (EEG) activity of cognitively preserved Par... |
[
{
"from": "human",
"value": "Question: Does subclinical left ventricular dysfunction by echocardiographic speckle-tracking strain analysis relate to outcome in sarcoidosis?\nContext: {'contexts': ['Limited data exist on the risk of developing cardiac sarcoidosis (CS) and/or adverse events in sarcoidosis pat... |
[
{
"from": "human",
"value": "Question: Are guanine quadruplexes formed by specific regions of human transposable elements?\nContext: {'contexts': ['Transposable elements form a significant proportion of eukaryotic genomes. Recently, Lexa et al. (Nucleic Acids Res 42:968-978, 2014) reported that plant long t... |
[
{
"from": "human",
"value": "Question: Is circulating soluble LR11 , a novel marker of smooth muscle cell proliferation , enhanced after coronary stenting in response to vascular injury?\nContext: {'contexts': ['Restenosis after vascular intervention remains a major clinical problem. Circulating LR11 has be... |
[
{
"from": "human",
"value": "Question: Are de novo donor-specific HLA antibodies associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation?\nContext: {'contexts': ['The development of human leukocyte antigen (HLA) antibody responses has been associated with ... |
[
{
"from": "human",
"value": "Question: Does a systematic review identify valid comorbidity indices derived from administrative health data?\nContext: {'contexts': ['To conduct a systematic review of studies reporting on the development or validation of comorbidity indices using administrative health data an... |
[
{
"from": "human",
"value": "Question: Do comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production?\nContext: {'contexts': [\"The consumption of an agrarian diet is associated with a reduced risk for many diseases associated with a 'Westernis... |
[
{
"from": "human",
"value": "Question: Is disruption of SOX6 associated with a rapid-onset dopa-responsive movement disorder , delayed development , and dysmorphic features?\nContext: {'contexts': ['Sox6 is a transcription factor that is crucial for the differentiation and development of cortical interneuro... |
[
{
"from": "human",
"value": "Question: Does capsular closure affect development of heterotopic ossification after hip arthroscopy?\nContext: {'contexts': ['The purpose of this study was to evaluate the role of capsular closure after hip arthroscopy in reduction of the incidence of heterotopic ossification (... |
[
{
"from": "human",
"value": "Question: Do smoking and unstable hinge fractures cause delayed gap filling irrespective of early weight bearing after open wedge osteotomy?\nContext: {'contexts': ['The purpose of this study was to examine the osteotomy gap filling rate with new bone after open wedge high tibia... |
[
{
"from": "human",
"value": "Question: Is topical clobetasol in conjunction with topical tretinoin effective in preventing scar formation after superficial partial-thickness burn ulcers of the skin : A retrospective study?\nContext: {'contexts': ['Deep erythema and inflammation after re-epithelialization of... |
[
{
"from": "human",
"value": "Question: Does the rate of hypo-osmotic challenge influence regulatory volume decrease ( RVD ) and mechanical properties of articular chondrocytes?\nContext: {'contexts': ['Osteoarthritis (OA) is associated with a gradual reduction in the interstitial osmotic pressure within art... |
[
{
"from": "human",
"value": "Question: Does liver-specific deletion of augmenter of liver regeneration accelerate development of steatohepatitis and hepatocellular carcinoma in mice?\nContext: {'contexts': ['Augmenter of liver regeneration (ALR, encoded by GFER) is a widely distributed pleiotropic protein o... |
[
{
"from": "human",
"value": "Question: Does transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveal proton pump inhibitor-reversible allergic inflammation?\nContext: {'contexts': ['Esophageal eosinophilia can be proton pump inhibitor (PPI) resistant or responsive, represent... |
[
{
"from": "human",
"value": "Question: Is a high normal thyroid-stimulating hormone associated with arterial stiffness , central systolic blood pressure , and 24-hour systolic blood pressure in males with treatment-naïve hypertension and euthyroid?\nContext: {'contexts': ['We compared the results of laborat... |
[
{
"from": "human",
"value": "Question: Does rotenone impair autophagic flux and lysosomal functions in Parkinson 's disease?\nContext: {'contexts': ['Rotenone is an environmental neurotoxin that induces accumulation of α-synuclein and degeneration of dopaminergic neurons in substantia nigra pars compacta (S... |
[
{
"from": "human",
"value": "Question: Is interleukin-6 associated with obesity , central fat distribution , and disease severity in patients with acute pancreatitis?\nContext: {'contexts': ['Acute pancreatitis (AP) is a systemic inflammatory disease, and cytokines are suggested to be related to the course ... |
[
{
"from": "human",
"value": "Question: Is platelet activation associated with myocardial infarction in patients with pneumonia?\nContext: {'contexts': ['Troponins may be elevated in patients with pneumonia, but associations with myocardial infarction (MI) and with platelet activation are still undefined.', ... |
[
{
"from": "human",
"value": "Question: Is fasting serum dipeptidyl peptidase-4 activity independently associated with alanine aminotransferase in type 1 diabetic patients?\nContext: {'contexts': ['Dipeptidyl peptidase-4 (DPP4) was recently proposed as a novel adipokine linked to insulin resistance (IR). As ... |
[
{
"from": "human",
"value": "Question: Is initial combination therapy with metformin , pioglitazone and exenatide more effective than sequential add-on therapy in subjects with new-onset diabetes . Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes ( EDICT ) : a rand... |
[
{
"from": "human",
"value": "Question: Does diet-induced obesity prevent the development of acute traumatic coagulopathy?\nContext: {'contexts': ['Obesity and hemorrhagic shock following trauma are predictors of mortality but have conflicting effects on coagulation. Following hemorrhage, tissue injury and h... |
[
{
"from": "human",
"value": "Question: Do endothelial progenitor cells induce transplant arteriosclerosis via VEGFR-1/2 activity?\nContext: {'contexts': ['Acute rejection (AR) after organ transplantation results in transplant arteriosclerosis (TA). Endothelial progenitor cells (EPCs) are involved in tissue ... |
[
{
"from": "human",
"value": "Question: Are elevated beta2-glycoprotein I-low-density lipoprotein levels associated with the presence of diabetic microvascular complications?\nContext: {'contexts': ['To investigate serum beta2-glycoprotein I-low-density lipoprotein (β2-GPI-LDL) and oxidized low-density lipop... |
[
{
"from": "human",
"value": "Question: Is bone marrow from blotchy mice dispensable to regulate blood copper and aortic pathologies but required for inflammatory mediator production in LDLR-deficient mice during chronic angiotensin II infusion?\nContext: {'contexts': ['The blotchy mouse caused by mutations ... |
[
{
"from": "human",
"value": "Question: Are maternal salivary cortisol levels during pregnancy positively associated with overweight children?\nContext: {'contexts': ['Animal and human studies suggest that programing of the hypothalamic-pituitary-adrenal (HPA) axis may be involved in the development of obesi... |
[
{
"from": "human",
"value": "Question: Is less advanced disease at initiation of salvage androgen deprivation therapy associated with decreased mortality following biochemical failure post-salvage radiation therapy?\nContext: {'contexts': ['The optimal clinical context for initiation of salvage androgen dep... |
[
{
"from": "human",
"value": "Question: Is low postoperative platelet count associated with negative outcome after liver resection for hepatocellular carcinoma?\nContext: {'contexts': ['Hepatocellular carcinoma is one of the most common malignancies worldwide. The only curative treatment is surgery. As hepat... |
[
{
"from": "human",
"value": "Question: Does early menarche increase the risk of Type 2 diabetes in young and middle-aged Korean women?\nContext: {'contexts': ['To investigate the association between early menarche (menarche age < 12 years) and Type 2 diabetes mellitus in young and middle-aged Korean women.'... |
[
{
"from": "human",
"value": "Question: Does twenty-four hour in-hospital congenital cardiac surgical coverage improve perioperative ECMO support outcomes?\nContext: {'contexts': ['Extracorporeal membrane oxygenation (ECMO) support is often required in the management of perioperative congenital heart surgery... |
[
{
"from": "human",
"value": "Question: Does early primary repair of tetralogy of Fallot lead to increased postoperative resource utilization?\nContext: {'contexts': ['Although early primary repair of tetralogy of Fallot has gained wider acceptance, there is some speculation that repair at a younger age may ... |
[
{
"from": "human",
"value": "Question: Are aggregate National Early Warning Score ( NEWS ) values more important than high scores for a single vital signs parameter for discriminating the risk of adverse outcomes?\nContext: {'contexts': ['The Royal College of Physicians (RCPL) National Early Warning Score (... |
[
{
"from": "human",
"value": "Question: Are plant communities on infertile soils less sensitive to climate change?\nContext: {'contexts': ['Much evidence suggests that plant communities on infertile soils are relatively insensitive to increased water deficit caused by increasing temperature and/or decreasing... |
[
{
"from": "human",
"value": "Question: Does licochalcone-A sensitize human esophageal carcinoma cells to TRAIL-mediated apoptosis by proteasomal degradation of XIAP?\nContext: {'contexts': ['Esophageal carcinoma is one of the most aggressive human cancers, and novel treatment modality is required. Although ... |
[
{
"from": "human",
"value": "Question: Is intranodal cytokeratin particles a predictive marker of efficacy for neoadjuvant therapies in patients with squamous cell carcinoma of the esophagus?\nContext: {'contexts': ['Lymph node metastasis is one of the most important prognostic factors in patients with esop... |
[
{
"from": "human",
"value": "Question: Does iNKT/CD1d-antitumor immunotherapy significantly increase the efficacy of therapeutic CpG/peptide-based cancer vaccine?\nContext: {'contexts': ['Therapeutic cancer vaccines aim to boost the natural immunity against transformed cancer cells, and a series of adjuvant... |
[
{
"from": "human",
"value": "Question: Is pseudomonas aeruginosa in CF and non-CF homes found predominantly in drains?\nContext: {'contexts': ['For patients with cystic fibrosis (CF) Pseudomonas aeruginosa infection is a major contributor to progressive lung disease. While colonizing strains are thought to ... |
[
{
"from": "human",
"value": "Question: Is increased expression of pleiotrophin a prognostic marker for patients with gastric cancer?\nContext: {'contexts': ['BACKGROUND/AIMs: Pleiotrophin (PTN) have been demonstrated to play an important role in the development of human gastric cancer. However, the prognost... |
[
{
"from": "human",
"value": "Question: Does the CC-genotype of the cyclooxygenase-2 gene associate with decreased risk of nasopharyngeal carcinoma in a Tunisian population?\nContext: {'contexts': [\"The cyclooxygenase-2 (cox-2) pathway is now recognized to be important in human cancer development and progre... |
[
{
"from": "human",
"value": "Question: Does a shoe insole delivering subsensory vibratory noise improve balance and gait in healthy elderly people?\nContext: {'contexts': [\"To test whether subsensory vibratory noise applied to the sole of the foot using a novel piezoelectric vibratory insole can significan... |
[
{
"from": "human",
"value": "Question: Do sleep spindle and slow wave frequency reflect motor skill performance in primary school-age children?\nContext: {'contexts': ['The role of sleep in the enhancement of motor skills has been studied extensively in adults. We aimed to determine involvement of sleep and... |
[
{
"from": "human",
"value": "Question: Does the dual CCR5 and CCR2 inhibitor cenicriviroc redistribute HIV into extracellular space : implications for plasma viral load and intracellular DNA decline?\nContext: {'contexts': ['Cenicriviroc is a potent antagonist of the chemokine coreceptors 5 and 2 (CCR5/CCR2... |
[
{
"from": "human",
"value": "Question: Do our experiences on the reconstruction of lateral scalp burn alopecia with tissue expanders?\nContext: {'contexts': ['Cicatricial alopecia is a form of hair loss that causes both cosmetic and psychological concerns. Although tissue expanders are the common approach t... |
[
{
"from": "human",
"value": "Question: Is prostate-specific antigen doubling time subsequent to radical prostatectomy a predictor of outcome following salvage external beam radiation therapy : a single-centre experience?\nContext: {'contexts': ['The aim of this study was to review the impact of salvage exte... |
[
{
"from": "human",
"value": "Question: Is head-shaft angle a risk factor for hip displacement in children with cerebral palsy?\nContext: {'contexts': ['Hip dislocation in children with cerebral palsy (CP) is a common and severe problem. The Swedish follow-up program for CP (CPUP) includes standardized monit... |
[
{
"from": "human",
"value": "Question: Is implementation of a surgical intensive care unit service associated with improved outcomes for trauma patients?\nContext: {'contexts': ['Our trauma service recently transitioned from a pulmonary intensive care unit (ICU) service to a surgical ICU (SICU) service. We ... |
[
{
"from": "human",
"value": "Question: Does elevated amygdala activity during reappraisal anticipation predict anxiety in avoidant personality disorder?\nContext: {'contexts': ['Avoidant personality disorder is characterized by pervasive anxiety, fear of criticism, disapproval, and rejection, particularly i... |
[
{
"from": "human",
"value": "Question: Does prenatal marijuana exposure predict marijuana use in young adulthood?\nContext: {'contexts': ['Studies have reported effects of prenatal marijuana exposure (PME) on cognitive and behavioral outcomes. An earlier publication from this study found that PME predicted ... |
[
{
"from": "human",
"value": "Question: Does nAIF1 inhibit gastric cancer cells migration and invasion via the MAPK pathways?\nContext: {'contexts': ['Nuclear apoptosis-inducing factor 1 (NAIF1) could induce apoptosis in gastric cancer cells. Previously, we have reported that the expression of NAIF1 protein ... |
[
{
"from": "human",
"value": "Question: Is cMV specific cytokine release assay in whole blood optimized by combining synthetic CMV peptides and toll like receptor agonists?\nContext: {'contexts': ['Interferon gamma release assays (IGRAs) are widely used to detect pathogen specific cellular immunity. Cytomega... |
[
{
"from": "human",
"value": "Question: Does light alcohol consumption play a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome?\nContext: {'contexts': ['Although excess alcohol consumption has been believed to cause liver injury, light alcohol consumption (LAC... |
[
{
"from": "human",
"value": "Question: Do genomic selection accuracies within and between environments and small breeding groups in white spruce?\nContext: {'contexts': ['Genomic selection (GS) may improve selection response over conventional pedigree-based selection if markers capture more detailed informa... |
[
{
"from": "human",
"value": "Question: Do local and general anaesthesia influence outcome of transfemoral aortic valve implantation?\nContext: {'contexts': ['There is great variability for the type of anaesthesia used during TAVI, with no clear consensus coming from comparative studies or guidelines. We sou... |
[
{
"from": "human",
"value": "Question: Does multidrug resistant bacteriuria before percutaneous nephrolithotomy predict for postoperative infectious complications?\nContext: {'contexts': ['Multidrug resistant (MDR) uropathogens are increasing in prevalence and may contribute to significant morbidity after p... |
[
{
"from": "human",
"value": "Question: Is higher fibrinogen level independently linked with the presence and severity of new-onset coronary atherosclerosis among Han Chinese population?\nContext: {'contexts': ['Fibrinogen is a coagulation/inflammatory biomarker strongly associated with atherogenesis. Howeve... |
[
{
"from": "human",
"value": "Question: Is the combination of pill count and self-reported adherence a strong predictor of first-line ART failure for adults in South Africa?\nContext: {'contexts': ['Suboptimal adherence to antiretroviral therapy (ART) is a strong predictor of virologic failure (VF) among peo... |
[
{
"from": "human",
"value": "Question: Does microRNA-19a enhance proliferation of bronchial epithelial cells by targeting TGFβR2 gene in severe asthma?\nContext: {'contexts': ['Allergic asthma is characterized by inflammation and airway remodeling. Bronchial epithelium is considered a key player in coordina... |
[
{
"from": "human",
"value": "Question: Are serum triglycerides , but not cholesterol or leptin , decreased in suicide attempters with mood disorders?\nContext: {'contexts': ['Many peripheral biomarkers, including low cholesterol and its fractions, have been examined to identify suicidal behavior. Herein, we... |
[
{
"from": "human",
"value": "Question: Is soft drink consumption associated with depressive symptoms among adults in China?\nContext: {'contexts': ['Research evidence supports a positive link between soft drinks and depressive symptoms. However, data thus far are only from Caucasian populations. We investig... |
[
{
"from": "human",
"value": "Question: Is blood alcohol concentration negatively associated with gambling money won on the Iowa gambling task in naturalistic settings after controlling for trait impulsivity and alcohol tolerance?\nContext: {'contexts': ['Acute alcohol intoxication has been found to increase... |
[
{
"from": "human",
"value": "Question: Does sexual activity predispose to reflux episodes in patients with gastroesophageal reflux disease?\nContext: {'contexts': ['The role of sexual activity on gastroesophageal reflux disease (GERD) is an under-recognized concern of patients, and one rarely assessed by ph... |
[
{
"from": "human",
"value": "Question: Is vascular injury associated with increased mortality in winter sports trauma?\nContext: {'contexts': ['Trauma is the leading cause of injury and death for individuals aged 1-44 years. Up to 8% of the US population participates in winter sports, and although vascular ... |
[
{
"from": "human",
"value": "Question: Is a common variant in RAB27A gene associated with fractional exhaled nitric oxide levels in adults?\nContext: {'contexts': ['Exhaled nitric oxide (FeNO) is a biomarker for eosinophilic inflammation in the airways and for responsiveness to corticosteroids in asthmatics... |
[
{
"from": "human",
"value": "Question: Does a dietary phytochemical blend prevent liver damage associated with adipose tissue mobilization in ovariectomized rats?\nContext: {'contexts': ['Menopausal reduction in estrogen causes increased adipose accumulation, leading many to turn to dietary supplements to p... |
[
{
"from": "human",
"value": "Question: Is real-time three-dimensional transesophageal echocardiography useful for percutaneous closure of multiple secundum atrial septal defects?\nContext: {'contexts': ['The purpose of this study was to investigate the clinical value of real-time three-dimensional transesop... |
[
{
"from": "human",
"value": "Question: Do longitudinal patterns of cortisol regulation differ in maltreated and nonmaltreated children?\nContext: {'contexts': ['Child maltreatment is associated with dysregulation of stress-mediating systems and an increased risk of mental and physical health problems. Speci... |
[
{
"from": "human",
"value": "Question: Does substance Use and Related harm Among Adolescents With and Without Traumatic Brain Injury?\nContext: {'contexts': ['The relationship between self-reported lifetime traumatic brain injury (TBI) and drug and alcohol use and associated harms was examined using an epid... |
[
{
"from": "human",
"value": "Question: Is eGFR-TKI effective regardless of treatment timing in pulmonary adenocarcinoma with EGFR mutation?\nContext: {'contexts': ['Although epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have become key therapeutic agents for non-small cell lung can... |
[
{
"from": "human",
"value": "Question: Is diabetes associated with increased risk of venous thromboembolism : a systematic review and meta-analysis?\nContext: {'contexts': ['Increasing evidence suggests an association between diabetes and risk of venous thromboembolism (VTE); however, the results are incons... |
[
{
"from": "human",
"value": "Question: Is invasion of uterine cervical squamous cell carcinoma cells facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta?\nContext: {'contexts': ['Local invasion is a common pattern of spread in uterine cer... |
[
{
"from": "human",
"value": "Question: Is increased serum cancer antigen-125 a marker for severity of deep endometriosis?\nContext: {'contexts': ['To determine whether cancer antigen-125 (CA-125) levels are increased in women with endometriosis, especially in those with endometriomas (OMAs), deep infiltrati... |
[
{
"from": "human",
"value": "Question: Do detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities?\nContext: {'contexts': ['We examined the phenotype and function of lymphocytes collected from the peripheral blood (PBL) and tumor (TIL... |
[
{
"from": "human",
"value": "Question: Do long-term lung cancer survivors have permanently decreased quality of life after surgery?\nContext: {'contexts': ['Retrospective evaluation of the long-term health-related quality of life (HRQoL) among survivors after non-small-cell lung cancer (NSCLC) surgery.', 'A... |
[
{
"from": "human",
"value": "Question: Does pregestational maternal obesity impair endocrine pancreas in male F1 and F2 progeny?\nContext: {'contexts': ['The aim of this study was to evaluate the effects of maternal obesity on pancreas structure and carbohydrate metabolism in early adult life, focusing on t... |
[
{
"from": "human",
"value": "Question: Does chloroquine enhance temozolomide cytotoxicity in malignant gliomas by blocking autophagy?\nContext: {'contexts': ['In a recent clinical trial, patients with newly diagnosed glioblastoma multiforme benefited from chloroquine (CQ) in combination with conventional th... |
[
{
"from": "human",
"value": "Question: Is long-term therapy with temozolomide a feasible option for newly diagnosed glioblastoma : a single-institution experience with as many as 101 temozolomide cycles?\nContext: {'contexts': [\"The objective of this study was to report the authors' experience with the lon... |
[
{
"from": "human",
"value": "Question: Is thiazide-induced hyponatraemia associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2?\nContext: {'contexts': ['Hyponatraemia is a common, potentially life-threatening, complication ... |
[
{
"from": "human",
"value": "Question: Is weight based heparin dosing for thromboembolic disease associated with earlier anticoagulation in surgical patients?\nContext: {'contexts': ['Achievement of early therapeutic anticoagulation with unfractionated heparin (UFH) is associated with improved outcomes in t... |
[
{
"from": "human",
"value": "Question: Does prospective international cohort study demonstrate inability of interim PET to predict treatment failure in diffuse large B-cell lymphoma?\nContext: {'contexts': ['The International Atomic Energy Agency sponsored a large, multinational, prospective study to furthe... |
[
{
"from": "human",
"value": "Question: Does fungal metabolite myriocin promote human herpes simplex virus-2 infection?\nContext: {'contexts': ['Myriocin is a fungal metabolite with antiviral activity, including influenza, hepatitis B, and hepatitis C viruses. We investigated whether myriocin has activity ag... |
[
{
"from": "human",
"value": "Question: Does prenatal zinc reduce stress response in adult rat offspring exposed to lipopolysaccharide during gestation?\nContext: {'contexts': ['Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 μg/kg, intraperitoneally)... |
[
{
"from": "human",
"value": "Question: Are global histone H3 lysine 27 triple methylation levels reduced in vessels with advanced atherosclerotic plaques?\nContext: {'contexts': ['Alterations in epigenetic processes are frequently noted in human disease. These epigenetic processes involve methylation of DNA... |
[
{
"from": "human",
"value": "Question: Does corn silk maysin induce apoptotic cell death in PC-3 prostate cancer cells via mitochondria-dependent pathway?\nContext: {'contexts': ['Despite recent advances in prostate cancer diagnostics and therapeutics, the overall survival rate still remains low. This study... |
[
{
"from": "human",
"value": "Question: Do some Strychnos spinosa ( Loganiaceae ) leaf extracts and fractions have good antimicrobial activities and low cytotoxicities?\nContext: {'contexts': ['Strychnos spinosa Lam. is a deciduous tree used in traditional medicine to treat infectious diseases. This study is... |
[
{
"from": "human",
"value": "Question: Does maternal immune activation in nonhuman primates alter social attention in juvenile offspring?\nContext: {'contexts': ['Sickness during pregnancy is associated with an increased risk of offspring neurodevelopmental disorders. Rodent models have played a critical ro... |
[
{
"from": "human",
"value": "Question: Does atractylodes macrocephala Koidz stimulate intestinal epithelial cell migration through a polyamine dependent mechanism?\nContext: {'contexts': ['Atractylodes macrocephala Koidz (AMK), a valuable traditional Chinese herbal medicine, has been widely used in clinical... |
[
{
"from": "human",
"value": "Question: Does chronic exercise normalize changes in Cav 1.2 and KCa 1.1 channels in mesenteric arteries from spontaneously hypertensive rats?\nContext: {'contexts': [\"Regular physical activity is an effective non-pharmacological therapy for prevention and control of hypertensi... |
[
{
"from": "human",
"value": "Question: Does cXCR3 antagonist VUF10085 bound to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779?\nContext: {'contexts': ['The chemokine receptor CXCR3 is implicated in a variety of clinically important diseases, notably rheumatoid arthritis and... |
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