Split (1)

train · 500 rows

patient_id string	sex string	race_ethnicity string	geographic_region string	residence_type string	socioeconomic_status string	primary_language string	insurance_type string	primary_disease_category string	disease_class string	orpha_code int64	omim_number int64	inheritance_pattern string	disease_severity_index float64	expected_mortality_by18_untreated float64	age_at_symptom_onset_yrs float64	age_at_diagnosis_yrs float64	diagnostic_delay_years float64	prior_misdiagnoses_count int64	specialists_seen_count int64	pcp_visits_count int64	er_visits_pre_diagnosis int64	hospitalization_pre_diagnosis int64	newborn_screening_eligible int64	newborn_screening_caught int64	newborn_screening_age_at_flag_days float64	genetic_test_modality string	time_to_genetic_test_months float64	genetic_test_insurance_denial_flag int64	genetic_test_cost_usd int64	pathogenic_variant_confirmed int64	diagnosis_source string	diagnostic_odyssey_cost_usd float64	parent_self_advocacy_score float64	developmental_milestones_status string	gross_motor_quotient float64	fine_motor_quotient float64	expressive_language_quotient float64	receptive_language_quotient float64	cognitive_quotient float64	autism_spectrum_comorbid_flag int64	adhd_comorbid_flag int64	seizure_flag int64	seizure_onset_age_yrs float64	seizure_medications_count int64	cardiac_involvement_flag int64	lvh_severity string	respiratory_involvement_flag int64	fvc_pct_predicted float64	niv_use_flag int64	tracheostomy_flag int64	gi_involvement_flag int64	g_tube_flag int64	hepatic_involvement_flag int64	renal_involvement_flag int64	ophthalmologic_involvement_flag int64	hearing_loss_flag int64	skeletal_involvement_flag int64	short_stature_zscore float64	bmi_zscore float64	plasma_amino_acids_abnormal int64	urine_organic_acids_abnormal int64	acylcarnitine_profile_abnormal int64	urine_gag_elevated int64	chitotriosidase_u_l float64	lyso_gb1_ng_ml float64	lyso_gb3_ng_ml float64	gaa_activity_nmol_hr_mg float64	gla_activity_nmol_hr_mg float64	ammonia_umol_l float64	lactate_mmol_l float64	pyruvate_mmol_l float64	ck_u_l float64	ldh_u_l float64	ast_u_l float64	ferritin_ng_ml float64	soluble_il2r_u_ml float64	orphan_drug_available_for_condition int64	treatment_received string	ert_product string	gene_therapy_product string	aso_product string	small_molecule_product string	treatment_start_age_yrs float64	treatment_delay_from_dx_months float64	treatment_cost_annual_usd float64	payer_coverage_status string	appeal_submitted_flag int64	appeal_success_flag int64	time_to_treatment_access_months float64	patient_assistance_program_enrolled_flag int64	copay_out_of_pocket_annual_usd float64	icer_value_assessment string	qaly_estimate_per_year float64	treatment_adherence_pct float64	infusion_reaction_flag int64	antidrug_antibody_flag int64	treatment_efficacy_response string	hsct_performed_flag int64	hsct_donor_type string	hsct_gvhd_flag int64	hsct_engraftment_success_flag int64	disease_progression_velocity string	hospitalization_annual_count int64	hospitalization_days_annual int64	metabolic_crisis_count int64	icu_admission_flag int64	respiratory_failure_event_flag int64	ambulation_status_age18 string	communication_status_age18 string	g_tube_dependent_age18 int64	ventilator_dependent_age18 int64	school_placement string	iep_504_plan_flag int64	therapies_received_count int64	mortality_flag int64	age_at_death_yrs float64	cause_of_death string	hospice_palliative_care_flag int64	caregiver_zarit_score float64	caregiver_phq9_score float64	caregiver_gad7_score float64	caregiver_employment_disruption_flag int64	caregiver_lost_income_annual_usd float64	caregiver_sleep_hours_per_night float64	household_out_of_pocket_annual_usd float64	ped_qol_total float64	ped_qol_physical float64	ped_qol_emotional float64	ped_qol_social float64	ped_qol_school float64	sibling_impact_score float64	marital_strain_flag int64	divorce_separation_flag int64	parent_advocacy_group_member_flag int64	social_media_rare_community_engagement_flag int64	clinical_trial_participation_flag int64	natural_history_study_enrollment_flag int64	patient_registry_enrollment_flag int64	distance_to_specialty_center_miles float64	travel_burden_days_per_year int64	telehealth_use_flag int64	language_barrier_interpretation_needed_flag int64	immigration_status_concern_flag int64	food_insecurity_flag int64	housing_instability_flag int64	transportation_barrier_flag int64	missed_appointments_annual_count int64	sdoh_composite_risk_score float64
HCG5-0000200	Male	Black_non_Hispanic	Latin_America	Urban	Middle	Spanish	TRICARE	Achondroplasia	SKEL	15	100,800	AD	3.11	0.04	0.079	1.325	1.246	1	3	20	1	0	0	0	null	Single_gene	18.94	0	800	0	Metabolic_specialist	24,789.88	5.43	Delayed	105.4	120	97.8	86.8	71.4	1	0	1	3.3	0	0	null	1	125	0	0	0	0	0	0	0	0	1	-0.64	1.03	0	0	0	0	72.69	6.483	6.65	2.63	5.82	23.5	3.11	0.078	530.3	453.5	43.7	50.1	1,185.9	0	Small_molecule	null	null	null	Supportive_metabolic	2.48	27.38	199,064	Denied	0	0	13.74	1	2,077	Intermediate	0.355	0.616	0	0	Responder	0	null	0	0	Stable	3	16	1	1	0	Ambulatory	Verbal	1	0	Mainstream_with_support	1	0	1	15.78	Respiratory_failure	1	40.1	10.9	14.6	1	26,583	4.9	3,876	69.2	58.2	65.4	45.9	64.5	37.1	0	1	1	0	0	0	1	126.2	15	1	0	0	0	0	0	5	0.35
HCG5-0000201	Male	Black_non_Hispanic	Sub_Saharan_Africa	Rural	Middle	Other	Medicaid	22q11_2_DiGeorge	SYN	567	188,400	AD	4.85	0.08	0.209	4.704	4.495	7	11	13	2	0	0	0	null	WES	2.7	0	4,500	1	NBS_followup	56,647.75	6.12	Delayed	66.9	68.9	74.5	67.3	104.5	0	1	0	1.47	1	1	Moderate	0	113.7	0	0	0	0	0	0	0	0	0	-1.19	0.97	0	0	0	0	280.57	11.779	29.232	2.53	7.84	45	3.01	0.098	686.7	575.1	57.7	3,604.4	1,733.4	0	Supportive_only	null	null	null	null	null	20.45	0	Fully_covered	0	0	5.76	0	1,220	Low_value	0.482	null	0	0	Not_applicable	0	null	0	0	Slow_progression	2	32	1	0	0	Assisted	Limited_verbal	0	0	Mainstream	1	5	1	18	Respiratory_failure	1	24.3	17	17.8	1	20,359	3.3	3,031	57.9	53.4	57.5	49.3	52.8	57.4	0	0	1	1	1	0	0	63.4	13	0	1	0	0	0	0	1	1.15
HCG5-0000202	Male	Hispanic	North_America	Rural	Middle	Other	Commercial	MERRF	MITO	551	545,000	MT	7.76	0.22	10.235	18	8.925	3	9	21	4	0	0	0	null	Karyotype	4.76	0	1,200	1	Geneticist	7,809.24	8.09	Regression	55.2	35.7	57.3	76.3	46.6	0	1	0	3	1	0	null	1	60.4	1	0	1	1	0	0	1	1	0	-0.5	0.02	0	0	0	0	370.77	48.352	10.012	3.81	1.11	27.4	1.68	0.233	169.7	147.2	17.4	36.5	1,475	0	Supportive_only	null	null	null	null	null	7.44	0	Fully_covered	0	0	10.37	0	316	Intermediate	0.329	null	0	0	Not_applicable	0	null	0	0	Slow_progression	1	12	0	1	1	Wheelchair	AAC_device	1	0	Home_school_medical	0	0	1	18	Cardiac	1	66.4	14.4	17.2	0	0	5.2	6,737	65.7	47.1	51.5	42.3	26.2	30.9	0	0	1	1	0	0	1	507.9	15	1	1	0	0	0	0	2	0.57
HCG5-0000203	Female	Hispanic	Europe	Urban	High	Spanish	Commercial	Pompe_infantile	LSD	365	232,300	AR	7.6	0.85	0.028	0.028	0	0	2	8	1	0	1	1	10.1	Metabolic	0.72	0	900	1	NBS_followup	6,783.77	7.02	Regression	46.9	42.4	53.8	54.1	93.5	0	0	0	3.39	8	1	Moderate	0	98.6	0	0	0	1	0	0	1	1	1	-1.77	-0.93	0	0	0	0	132.22	14.4	6.216	4.36	2.25	20	1.9	0.148	50.6	156.1	61.4	1,764.5	21,392.5	1	ERT	Avalglucosidase_alfa	null	null	null	2.01	2.09	582,504	Denied	1	1	7.08	1	2,279	Intermediate	0.253	0.747	0	0	Non_responder	0	null	0	0	Slow_progression	7	19	2	0	0	Wheelchair	AAC_device	1	0	Special_ed	1	5	1	6.85	Cardiac	1	25.4	15.5	9.3	1	21,553	5.2	4,435	58.9	10.2	54.4	61.2	54.3	52.7	1	0	1	1	1	1	1	4.1	18	1	1	0	0	0	1	1	2.65
HCG5-0000204	Male	White_non_Hispanic	Europe	Urban	Middle	Other	Medicaid	Gaucher_type1	LSD	355	230,800	AR	6.07	0.05	1.572	5.179	3.607	3	11	5	3	1	0	0	null	Karyotype	24.21	0	1,200	0	Neurologist	52,840.86	3.83	Regression	58.3	71.3	77.7	75.3	70.4	1	0	0	2.33	8	0	null	1	65.4	0	0	1	0	0	0	0	1	1	0.02	-1.03	0	0	1	0	327.41	17.115	6.904	8.99	4.48	200.5	1.29	0.218	175	158.7	53.8	239.4	780.6	1	ERT	Velaglucerase	null	null	null	5.36	2.67	158,791	Prior_auth_required	0	0	26.79	0	291	Intermediate	0.325	0.77	0	0	Responder	0	null	0	0	Stable	5	47	2	1	0	Wheelchair	AAC_device	0	1	Home_school_medical	1	4	0	null	null	0	59.3	18.1	13.5	0	0	4.5	2,211	66.1	78.7	64.3	88.4	52.5	45.2	0	0	0	1	0	0	1	2.8	10	1	1	0	1	0	0	5	3.08
HCG5-0000205	Female	White_non_Hispanic	Sub_Saharan_Africa	Suburban	Middle	English	Medicaid	MPS_III_Sanfilippo	LSD	581	252,900	AR	8.43	0.7	3.047	6.372	3.325	3	9	15	8	0	0	0	null	WES	16.54	0	4,500	1	Geneticist	18,923.69	7.21	Profound_delay	48.2	56.9	68.3	54.8	47.6	1	0	0	0.8	2	0	null	1	53	0	0	1	0	0	0	1	1	1	-3.28	-2.12	0	0	0	1	183.57	29.079	4.054	4.85	3.2	64.3	1.9	0.193	101.4	294.7	59.9	200.1	4,152.4	0	Supportive_only	null	null	null	null	null	13.13	0	Prior_auth_required	0	0	10.9	0	387	Intermediate	0.489	null	0	0	Not_applicable	0	null	0	0	Stable	14	20	0	0	1	Bedbound	Nonverbal	1	1	Mainstream_with_support	1	1	1	12.53	Cardiac	1	43.2	16.5	8.8	1	156,624	6.3	10,226	39.7	52.9	51.3	21.6	32.4	50.5	0	0	1	0	0	0	1	41.5	4	0	0	0	0	1	1	4	4.81
HCG5-0000206	Female	Black_non_Hispanic	North_America	Suburban	High	English	Medicaid	Pompe_infantile	LSD	365	232,300	AR	8.48	0.85	0.017	0.017	0	0	4	6	1	0	1	1	6.1	Karyotype	1.88	0	1,200	1	NBS_followup	24,792.04	6	Profound_delay	75.5	51.4	34.6	64.3	10.8	1	0	1	1.08	2	1	Moderate	1	71.6	0	0	0	1	0	0	0	0	1	-1.88	-0.11	0	0	1	0	47.74	12.14	2.089	2.48	1.1	20	4.13	0.183	230.4	169.1	49.1	467.9	330.5	1	ASO	null	null	Custom_ASO	null	0.47	4.74	863,142	Partial_coverage	0	0	9.65	0	15,103	Intermediate	0.584	0.76	0	0	Responder	0	null	0	0	Stable	7	4	1	0	1	Bedbound	Nonverbal	1	0	Home_school_medical	1	6	0	null	null	0	36	9.9	5.4	1	100,651	5	19,410	38.7	26.6	17.3	71.8	100	19.5	0	0	0	1	1	1	1	222.3	5	0	0	0	0	0	0	1	0.72
HCG5-0000207	Female	White_non_Hispanic	Europe	Urban	Low	English	Commercial	MLD	LD	512	250,100	AR	9.82	0.7	0.013	0.013	0	0	3	18	1	0	1	1	4.7	Panel	1.07	1	1,500	0	NBS_followup	14,856.99	4.15	Profound_delay	52.7	23	48.5	19.3	89.7	1	0	1	1.03	4	0	null	0	84.6	0	0	0	0	0	0	1	0	0	-3.03	-1.38	0	0	0	0	264.68	3.687	2.647	25.79	6.58	20	3.69	0.113	135.2	678.7	57.6	87.2	693.7	1	HSCT	null	null	null	null	0.44	5.37	311,147	Partial_coverage	0	0	9.34	1	8,450	Intermediate	0.191	0.42	0	0	Responder	1	Cord	0	1	Slow_progression	3	8	3	1	0	Bedbound	Nonverbal	1	1	Home_school_medical	1	3	0	null	null	0	36.5	24.2	10.3	0	0	4.7	11,492	43.8	20.6	51.4	68	14.3	61	0	0	0	1	0	0	1	46	25	0	0	0	0	0	0	1	0
HCG5-0000208	Male	White_non_Hispanic	Latin_America	Urban	Low	English	Medicaid_CHIP	Pompe_infantile	LSD	365	232,300	AR	8.04	0.85	0.003	0.003	0	0	4	15	3	0	1	1	1.2	MLPA	0.5	0	1,000	1	NBS_followup	61,177.17	6.07	Profound_delay	62.6	71.2	16.5	51.5	53.3	0	0	0	5.77	5	1	Mild	1	32.7	1	0	0	1	1	0	0	0	1	-0.31	-1.1	0	0	1	0	134.22	11.344	12.694	3.62	8.76	20	3.11	0.17	32.7	330.4	33.4	580.3	1,327.2	1	ERT	Alglucosidase_alfa	null	null	null	1.58	9.2	843,076	Fully_covered	0	0	36	1	1,449	Intermediate	0.386	0.648	0	1	Partial	0	null	0	0	Stable	4	27	1	0	0	Bedbound	Nonverbal	0	1	Home_school_medical	0	2	1	14.57	Cardiac	1	49.1	2	15.1	1	108,374	4.7	7,173	61.1	58.2	37.5	57.6	55.9	90.8	1	0	1	1	0	0	1	34.4	7	1	0	0	0	0	0	13	0
HCG5-0000209	Male	White_non_Hispanic	North_America	Urban	Middle	English	Commercial	MERRF	MITO	551	545,000	MT	9.24	0.22	11.899	13.982	2.083	1	12	9	0	0	0	0	null	WES	48.82	0	4,500	1	Geneticist	35,217.37	8.18	Profound_delay	31.8	79.5	10	37.2	10	1	1	0	1.07	3	0	null	0	98.6	0	0	1	1	0	0	0	0	0	-1.3	0.6	0	0	0	0	13.27	19.913	22.297	2.17	2.57	20	3.96	0.183	1,119.2	496.5	61	629	1,586.1	0	Supportive_only	null	null	null	null	null	6.34	0	Partial_coverage	0	0	6.43	0	196	Intermediate	0.41	null	0	0	Not_applicable	0	null	0	0	Moderate	5	18	2	1	0	Bedbound	Nonverbal	1	1	Mainstream	1	6	0	null	null	0	44.3	19.2	10	0	0	4.1	5,555	53.8	42.5	74.8	45.5	54.8	45.8	1	0	0	1	0	0	0	6.8	10	1	0	0	1	0	0	3	0.66
HCG5-0000210	Female	Hispanic	Asia_Pacific	Rural	High	English	Commercial	X_ALD	LD	43	300,100	XLR	7.29	0.55	0.015	0.015	0	0	2	9	2	0	1	1	5.3	Panel	0.55	0	1,500	1	NBS_followup	33,409.57	7.7	Regression	36.5	55.4	87.3	65	79.5	1	0	0	4.18	8	1	Moderate	0	101.5	0	0	0	1	0	0	1	0	0	-0.38	2.3	0	0	0	0	122.64	33.839	117.571	0.99	6.79	158.6	1.79	0.399	206.7	285.4	99.6	247.9	1,374.1	1	ASO	null	null	Custom_ASO	null	0.07	1.46	193,120	Fully_covered	0	0	7.75	1	2,004	Intermediate	0.17	0.778	0	0	Responder	0	null	0	0	Stable	2	26	0	0	0	Wheelchair	AAC_device	1	0	Mainstream_with_support	1	3	0	null	null	0	47.9	15.8	18.1	0	0	5.1	10,781	65.8	50.4	65.5	69.2	40.3	27.8	0	0	1	1	0	0	1	39	15	1	1	0	0	0	0	4	0.73
HCG5-0000211	Female	Hispanic	North_America	Urban	Low	Spanish	Commercial	SMA_type2	NM	83,418	253,550	AR	7.18	0.25	0.016	0.016	0	0	4	7	1	0	1	1	5.7	WES	1.68	1	4,500	1	NBS_followup	9,389.45	6.4	Regression	60.3	89.9	42.7	58.2	57.3	0	0	0	3.38	2	1	Severe	1	51.8	1	1	0	1	0	0	0	1	0	-3.48	0.2	1	1	0	0	33.33	18.435	11.737	4.82	20.62	136.7	1.1	0.144	164.7	551.4	31.6	322.2	1,637	1	Supportive_only	null	null	null	null	null	2.31	0	Fully_covered	0	0	7.35	0	104	High_value	0.501	null	0	0	Not_applicable	0	null	0	0	Stable	10	14	0	1	1	Wheelchair	AAC_device	1	0	Not_enrolled	1	1	0	null	null	0	19.9	20.6	11.2	0	0	5.1	3,462	36.9	54.5	76.4	55.3	52.4	63.5	1	0	0	1	0	1	1	30.5	0	1	1	0	1	0	0	3	4.41
HCG5-0000212	Male	Black_non_Hispanic	MENA	Rural	Low	Mandarin	Other_public	MPS_II_Hunter	LSD	580	309,900	XLR	9.85	0.72	0.854	5.199	4.344	6	14	12	0	0	0	0	null	WGS	9.85	0	8,500	1	Geneticist	42,249.8	7.78	Profound_delay	58.4	55.4	36.3	24.3	22.4	0	0	0	5.92	5	1	Moderate	1	61.8	1	0	0	1	1	0	1	1	1	-2.52	-0.57	0	0	1	1	52.9	33.336	3.85	7.79	13.1	20	2.03	0.222	65	136.7	32.4	2,043.9	907.8	1	ERT	Idursulfase	null	null	null	5.74	2.37	104,514	Fully_covered	0	0	1.14	0	2,048	High_value	0.401	0.56	0	0	Responder	0	null	0	0	Stable	0	19	1	0	0	Bedbound	Nonverbal	1	1	Special_ed	1	6	0	null	null	0	21	12.6	6.1	1	8,132	5.5	13,925	21.4	40	41.9	45.1	50.1	39	0	0	1	0	0	0	1	45.3	3	0	0	0	0	0	0	1	0
HCG5-0000213	Male	White_non_Hispanic	Latin_America	Urban	Low	English	Commercial	SCID	IMM	183	300,400	XLR	9.21	0.92	0.021	0.021	0	0	2	9	0	0	1	1	7.8	Panel	1.94	0	1,500	1	NBS_followup	11,014.95	5	Profound_delay	71.1	85	10	33.7	67.1	1	1	1	4.54	2	0	null	0	109.1	0	0	1	1	0	0	0	0	0	-3.94	-0.43	0	1	0	0	141.32	51.021	11.874	1.8	2.67	247.8	2.12	0.157	138.3	356.2	69.5	500.8	6,552.3	1	Supportive_only	null	null	null	null	null	4.48	0	Prior_auth_required	0	0	7.27	0	456	Cost_saving	0.251	null	0	0	Not_applicable	0	null	0	0	Slow_progression	2	7	4	0	0	Bedbound	Nonverbal	1	1	Special_ed	1	0	1	0.91	Respiratory_failure	0	23.9	10.8	9.9	1	12,599	6.3	1,667	38.4	0	70.5	13.5	40.3	52.9	0	1	0	1	1	0	1	46.7	13	1	0	0	1	1	0	3	3.66
HCG5-0000214	Female	White_non_Hispanic	North_America	Rural	High	English	Commercial	Canavan	LD	141	271,900	AR	10	0.82	0.1	3.627	3.527	0	14	13	3	1	0	0	null	Single_gene	6.02	0	800	0	Immunologist	14,872.99	4.17	Profound_delay	10	47	10	66.3	10	0	0	1	3.06	6	0	null	0	86.9	0	0	0	1	1	1	0	0	0	-1.37	1.42	1	0	0	0	168.14	60.856	22.934	7.39	1.23	86.8	3.34	0.125	86.8	468.9	30.3	103.5	664.9	0	Supportive_only	null	null	null	null	null	11.01	0	Fully_covered	0	0	16.69	0	433	Intermediate	0.333	null	0	0	Not_applicable	0	null	0	0	Stable	6	40	4	0	0	Bedbound	Nonverbal	1	0	Mainstream_with_support	1	4	1	7.89	Metabolic_crisis	1	61.2	7.4	8.3	1	33,788	7.6	1,049	33.3	26.8	30.7	57.2	27.6	41.6	0	0	1	1	0	0	1	116.8	31	1	0	0	0	1	0	6	2.67
HCG5-0000215	Male	Black_non_Hispanic	Asia_Pacific	Urban	Low	Spanish	Commercial	OI_type1_to_4	SKEL	666	166,200	AD	3.16	0.06	0.714	6.838	6.124	1	14	6	3	1	0	0	null	WGS	31.58	0	8,500	1	Neurologist	7,872.94	8.12	Delayed	123.5	83	62.9	47.3	66	0	0	0	3.87	6	0	null	0	78.2	0	0	0	0	0	0	0	0	1	-2.31	0.22	0	0	0	0	78.65	25.922	30.789	4.79	4.08	48.6	3.02	0.234	58.4	489.1	27	558.7	3,806.5	1	Supportive_only	null	null	null	null	null	10.53	0	Partial_coverage	0	0	10.63	0	664	Intermediate	0.516	null	0	0	Not_applicable	0	null	0	0	Slow_progression	2	7	3	1	0	Ambulatory	Verbal	0	0	Special_ed	1	2	1	15.04	Respiratory_failure	1	64.8	5.6	16.4	1	25,339	7	11,088	45.2	66.7	65.3	91	55.3	24.7	1	0	0	1	0	1	1	33.8	13	1	1	1	1	1	1	3	10
HCG5-0000216	Female	White_non_Hispanic	North_America	Urban	Middle	English	Commercial	Pompe_infantile	LSD	365	232,300	AR	8.47	0.85	0.026	0.026	0	0	4	7	2	0	1	1	9.4	Metabolic	4.37	0	900	0	NBS_followup	23,367.76	3.27	Profound_delay	52.5	63.5	54.2	58.4	44.3	0	0	0	1.03	0	1	Severe	1	39.4	1	0	1	1	0	0	1	1	1	-0.89	-0.09	1	0	1	0	307.14	7.977	28.214	1.08	27.45	122.3	4.08	0.352	297.5	311.4	60.1	135.4	3,560.4	1	ERT	Alglucosidase_alfa	null	null	null	2.16	36.79	117,236	Partial_coverage	0	0	26.05	0	5,719	Low_value	0.596	0.695	0	0	Partial	0	null	0	0	Slow_progression	0	22	5	0	1	Bedbound	Nonverbal	1	1	Mainstream_with_support	0	5	1	1.2	Cardiac	0	45.1	12.5	13.6	1	28,069	3.9	2,052	45.1	52.5	37.7	23.4	30.4	56.7	0	0	1	1	0	0	0	21.4	8	1	0	0	0	0	0	1	0
HCG5-0000217	Male	Black_non_Hispanic	Europe	Rural	High	English	Commercial	Pompe_infantile	LSD	365	232,300	AR	9.48	0.85	0.02	0.02	0	0	2	6	5	0	1	1	7.3	WES	2.97	0	4,500	1	NBS_followup	70,124.39	6.76	Profound_delay	54.8	33	22.8	62	63.8	0	1	1	2.93	3	1	Mild	1	49.4	0	0	0	1	0	0	0	1	1	-1.76	0.02	0	0	0	0	161.66	7.239	20.399	7.39	11.07	87	0.66	0.184	139.4	155.2	33.1	109.4	700.8	1	Small_molecule	null	null	null	Supportive_metabolic	0.63	2.12	17,004	Fully_covered	0	0	13.56	1	630	Intermediate	0.481	0.924	0	0	Responder	0	null	0	0	Slow_progression	6	44	3	1	0	Bedbound	Nonverbal	1	1	Home_school_medical	1	1	1	10.72	Neurodegeneration	1	60	8.8	11.1	0	0	6.9	2,820	23.3	27.1	64.3	31.4	71.4	41.5	1	0	0	1	0	0	0	55.7	0	0	0	0	0	0	0	3	1.19
HCG5-0000218	Female	Hispanic	Europe	Rural	Low	English	Uninsured	CDKL5_encephalopathy	SYN	3,095	300,672	XLD	9.8	0.22	0.603	5.424	4.821	0	15	15	2	0	0	0	null	Single_gene	12.91	0	800	1	Geneticist	32,992.17	8.64	Profound_delay	10	47	24.4	47.3	92.5	0	0	1	1.12	1	0	null	0	121.8	0	0	0	1	0	0	0	0	0	-4.36	-2.69	0	0	0	0	118.63	7.872	13.273	3.63	3.3	45.4	1.38	0.126	600.8	605.3	105.1	430.1	1,252.6	0	Supportive_only	null	null	null	null	null	13.97	0	Fully_covered	0	0	10.5	0	3,093	Cost_saving	0.763	null	0	0	Not_applicable	0	null	0	0	Moderate	12	6	0	0	0	Bedbound	Nonverbal	1	0	Mainstream	1	4	0	null	null	0	54.7	9.7	15.2	1	152,947	7.1	2,126	35.5	34.9	85.1	39	59.7	27.3	0	0	1	1	0	1	1	53.5	12	0	0	0	0	1	0	3	1.47
HCG5-0000219	Female	White_non_Hispanic	Asia_Pacific	Urban	Middle	English	Medicaid_CHIP	OTC	UCD	664	311,250	XLR	8.92	0.52	0.178	1.349	1.17	2	8	9	1	0	0	0	null	WES	7.13	0	4,500	1	Cardiologist	18,076.38	4.83	Profound_delay	37.7	70	21.9	79.4	42.9	0	0	1	4.06	1	0	null	1	50.6	1	0	0	1	0	0	0	0	1	-3.79	0.22	1	0	1	0	189.31	8.437	23.644	1.82	13.55	26.2	2.11	0.199	158.8	300	32.3	80.6	1,803.6	1	Small_molecule	null	null	null	Supportive_metabolic	1.76	4.2	950,862	Fully_covered	0	0	14.88	1	13,034	High_value	0.621	0.794	0	0	Responder	0	null	0	0	Stable	6	29	2	0	1	Bedbound	Nonverbal	0	1	Special_ed	1	3	1	12.31	Other	1	65.5	7.3	7.4	1	23,050	6.7	10,900	30.3	61.5	60.8	44.8	44.3	56.8	0	0	0	1	0	0	0	14.2	12	1	0	0	0	0	1	3	1.04
HCG5-0000220	Female	White_non_Hispanic	North_America	Urban	Middle	English	Commercial	MMA	OA	27	251,000	AR	8.31	0.45	0.013	0.013	0	0	4	17	0	1	1	1	4.7	Single_gene	12	1	800	1	NBS_followup	29,680.09	4.7	Profound_delay	60.8	64	66.3	63.8	61.9	1	0	0	1.15	2	0	null	0	95.9	0	0	1	1	1	0	0	0	0	-1.7	-1.8	1	1	0	0	604.9	24.275	4.194	9.64	9.51	31.5	2.97	0.185	280.8	313.3	25.2	257.5	9,656.8	0	Supportive_only	null	null	null	null	null	72	0	Fully_covered	0	0	9.28	0	17,600	Cost_saving	0.519	null	0	0	Not_applicable	0	null	0	0	Slow_progression	1	32	2	1	0	Bedbound	Nonverbal	1	0	Home_school_medical	1	3	0	null	null	0	65.5	19.7	5.4	0	0	5.3	2,704	28.2	68.2	26.9	37.3	27.8	97.6	0	0	1	1	0	1	1	82.4	3	0	0	0	1	0	0	0	0.73
HCG5-0000221	Male	White_non_Hispanic	North_America	Urban	High	Mandarin	Commercial	MELAS	MITO	550	540,000	MT	8.27	0.28	2.091	5.061	2.97	0	11	17	1	0	0	0	null	Panel	4.09	0	1,500	1	Geneticist	29,532.68	6.85	Profound_delay	25.1	48.1	60.3	53.5	112.5	0	0	0	2.83	0	1	Moderate	1	47.9	0	1	1	1	0	0	1	1	0	-1.24	0.23	0	0	1	0	21.11	121.352	1.999	9.49	0.6	20	7.82	0.401	271.4	1,107.2	44.6	513.4	1,249.9	0	Small_molecule	null	null	null	Supportive_metabolic	5.41	8.88	125,332	Prior_auth_required	0	0	5.19	1	4,084	Cost_saving	0.294	0.743	0	0	Non_responder	0	null	0	0	Moderate	1	47	1	0	1	Bedbound	Nonverbal	1	0	Home_school_medical	1	4	0	null	null	0	31.3	9.1	4.8	1	33,212	7.6	24,103	27.2	46.8	42.6	77.1	37.3	67.9	1	1	0	1	0	0	1	13.6	37	0	1	0	0	0	1	3	5.2
HCG5-0000222	Male	Asian	Asia_Pacific	Urban	Middle	Spanish	Commercial	Myotonic_congenital	NM	590	160,900	AD	6.07	0.1	2.017	3.978	1.961	2	7	13	1	1	0	0	null	Single_gene	26.61	0	800	1	Other	28,551.42	7.39	Regression	10	66.2	47.3	51.7	64.9	0	0	0	1.94	1	1	Mild	0	79	0	0	0	0	0	0	0	0	0	-4.46	-1.58	0	0	0	0	664.83	26.862	80.152	1.79	8.63	20	1.24	0.222	388.3	383.1	60.6	1,999.6	50,000	0	Supportive_only	null	null	null	null	null	5.38	0	Partial_coverage	0	0	5.96	0	6,363	Intermediate	0.624	null	0	0	Not_applicable	0	null	0	0	Slow_progression	2	6	0	1	0	Wheelchair	AAC_device	0	0	Home_school_medical	1	2	0	null	null	0	49.6	15.2	1.4	0	0	4.7	12,940	37.2	64.6	100	96.5	36.8	49.2	0	0	1	1	1	0	0	111.9	3	1	0	0	0	0	0	2	0
HCG5-0000223	Female	Black_non_Hispanic	Europe	Urban	Middle	Spanish	Medicaid_CHIP	Williams	SYN	904	194,050	AD	1.93	0.04	0.117	2.375	2.258	0	11	13	7	0	0	0	null	WES	15.38	0	4,500	1	NBS_followup	31,558.59	4.39	On_track	93.5	102.4	100.9	95.1	99.1	0	1	0	1.81	1	1	Mild	1	35.7	0	0	1	0	1	0	0	0	0	-1.9	0.55	0	0	0	0	97.84	20.582	11.678	5.67	3.69	455	1.45	0.114	89.2	281.6	55.9	493.8	3,896.7	0	Supportive_only	null	null	null	null	null	13.49	0	Partial_coverage	0	0	0.78	0	3,175	Intermediate	0.282	null	0	0	Not_applicable	0	null	0	0	Moderate	3	45	1	0	0	Ambulatory	Verbal	0	0	Mainstream	1	2	0	null	null	0	55.5	10.8	4.2	0	0	7.1	7,819	74.5	66.3	83.7	70.1	57.9	95.1	0	0	1	1	0	0	0	30.6	6	1	0	0	0	0	0	5	0.01
HCG5-0000224	Male	White_non_Hispanic	Europe	Rural	Low	English	Commercial	MMA	OA	27	251,000	AR	9.23	0.45	0.015	0.015	0	0	4	17	4	1	1	1	5.6	Panel	1.04	0	1,500	1	NBS_followup	10,551.31	3.83	Profound_delay	39.1	56.5	30.2	53	19.2	0	0	0	1.42	4	0	null	1	57.2	0	0	1	1	0	1	0	0	0	-3.02	-0.64	1	1	1	0	83.19	52.757	19.698	5.27	1.52	20	1.73	0.275	719.8	273.3	65.2	48.6	2,549.1	0	Small_molecule	null	null	null	Supportive_metabolic	1.84	12.39	671,548	Fully_covered	0	0	28.09	1	3,521	Intermediate	0.554	0.602	0	0	Responder	0	null	0	0	Moderate	4	39	4	1	0	Bedbound	Nonverbal	1	1	Special_ed	1	2	0	null	null	0	61.4	15.9	14.1	0	0	7	29,714	41.8	51.4	38.8	36.4	6.5	24.3	0	0	1	1	0	0	1	15.6	8	0	0	0	1	0	0	3	3.87
HCG5-0000225	Male	Asian	North_America	Urban	Middle	Mandarin	Commercial	CDKL5_encephalopathy	SYN	3,095	300,672	XLD	7.49	0.22	0.279	2.581	2.302	2	10	14	1	0	0	0	null	Single_gene	13.27	0	800	1	Other	29,610.51	7.41	Regression	77.2	67.8	40.4	51.4	99.6	0	0	1	5.62	4	0	null	1	43.6	1	0	0	0	1	0	1	0	0	-3.13	-2.23	0	1	0	0	121.25	10.531	0.979	4.24	3.6	20	1.42	0.225	59.4	504	30.3	57.7	4,377.4	0	Supportive_only	null	null	null	null	null	6.57	0	Partial_coverage	0	0	5.59	0	147	High_value	0	null	0	0	Not_applicable	0	null	0	0	Slow_progression	2	14	1	0	1	Wheelchair	AAC_device	1	0	Mainstream_with_support	0	1	1	6.35	Respiratory_failure	0	58.7	11.7	14.5	1	76,564	6.4	2,358	53.3	42.3	74.5	56.7	33.9	60.2	0	1	1	0	0	0	1	1,152.2	13	1	0	0	0	0	1	2	1.21
HCG5-0000226	Male	White_non_Hispanic	North_America	Suburban	Middle	Spanish	Uninsured	Gaucher_type1	LSD	355	230,800	AR	5.38	0.05	0.342	5.777	5.436	3	10	20	0	0	0	0	null	Panel	6.62	0	1,500	0	Other	5,542.92	7.44	Delayed	62.2	73.1	61.3	50.9	53.1	0	0	0	5.42	2	0	null	0	116	0	0	1	0	0	0	1	1	1	-2.59	-0.87	0	0	1	0	74.69	56.703	48.931	2.97	4.82	129.7	1.31	0.24	257.5	242.2	99	1,634.3	324.2	1	ERT	Imiglucerase	null	null	null	6.27	19.17	313,009	Fully_covered	0	0	2.61	0	9,446	High_value	0.331	0.886	1	0	Non_responder	0	null	0	0	Slow_progression	0	9	1	0	0	Assisted	Limited_verbal	0	0	Not_enrolled	0	6	0	null	null	0	45.8	17.3	6	1	293,108	3.6	6,837	52.9	36.8	63.6	35.7	27.3	78.6	0	0	1	0	1	1	0	61.3	14	1	0	0	0	0	1	10	2.11
HCG5-0000227	Male	White_non_Hispanic	Latin_America	Urban	Low	English	Medicaid	SMA_type1	NM	83,330	253,300	AR	9.72	0.9	0.01	0.01	0	0	3	15	8	0	1	1	3.5	WES	1.69	1	4,500	1	NBS_followup	45,164.26	4	Profound_delay	35.3	24.1	45.5	14	49.5	0	0	1	3.69	1	1	Severe	1	52.6	1	0	0	1	0	0	0	0	1	-1.65	3.13	0	0	0	0	64.05	53.044	34.477	3.98	1.62	51.8	2.29	0.197	57.6	471.5	14	121.8	5,836.4	1	Supportive_only	null	null	null	null	null	52.53	0	Fully_covered	0	0	4.81	0	1,132	Low_value	0.168	null	0	0	Not_applicable	0	null	0	0	Stable	3	30	0	0	0	Bedbound	Nonverbal	1	1	Special_ed	1	3	1	5.28	Infection	1	59.2	17.6	1.4	1	148,346	6	608	57.2	72.9	100	44.3	25.1	36.5	0	0	1	1	1	0	1	174.7	6	1	0	0	1	0	0	4	2.11
HCG5-0000228	Male	Asian	North_America	Urban	Middle	Spanish	Commercial	CMT_1A_1B	NM	101,081	118,220	AD	4.06	0.02	12	13.541	1.541	2	7	10	1	1	0	0	null	Panel	15.13	0	1,500	1	Geneticist	9,971.89	8.12	Delayed	86.2	62.2	52.9	77.2	81.8	0	0	1	4.81	1	0	null	0	87	0	0	0	0	1	0	0	0	0	-2.65	-4.04	0	0	0	0	422.77	23.408	2.977	9.5	2.98	56.1	4.02	0.247	211.7	633.1	25.9	46.1	481.6	0	Supportive_only	null	null	null	null	null	27.38	0	Partial_coverage	0	0	32.51	0	9,881	Cost_saving	0.368	null	0	0	Not_applicable	0	null	0	0	Slow_progression	3	14	1	0	0	Assisted	Limited_verbal	0	0	Home_school_medical	1	2	0	null	null	0	25.4	19.5	8	0	0	6.8	3,541	68.9	88.8	65.2	71.9	95	53.1	1	0	1	0	1	1	0	50.4	15	1	1	0	0	0	0	10	2.05
HCG5-0000229	Male	White_non_Hispanic	North_America	Suburban	High	English	Commercial	Fabry	LSD	324	301,500	XLR	3.67	0.04	6.105	8.358	2.253	4	9	20	10	1	0	0	null	Single_gene	120	0	800	1	Geneticist	77,640	4.47	Delayed	94.7	86	84.8	48	80.6	0	0	0	0.85	3	0	null	0	84	0	0	0	0	1	1	0	1	1	-4.18	-0.13	0	0	1	0	212.66	146.112	9.156	6.22	2.47	29.4	2.39	0.197	712.7	349.3	45.9	81	4,314.2	1	ASO	null	null	Custom_ASO	null	9.53	8.47	343,482	Partial_coverage	0	0	7.13	0	7,603	High_value	0.143	0.9	0	0	Responder	0	null	0	0	Stable	1	48	0	0	0	Ambulatory	Verbal	0	0	Mainstream_with_support	1	5	0	null	null	0	25.7	8.1	12.4	1	25,447	5.9	1,608	70.4	54.5	59.8	74.9	48.6	37.9	1	0	0	0	0	1	1	231.3	39	1	0	0	0	0	0	18	0.92
HCG5-0000230	Male	White_non_Hispanic	MENA	Urban	Low	English	Uninsured	Pompe_infantile	LSD	365	232,300	AR	6.67	0.85	0.003	0.003	0	0	2	7	7	0	1	1	1	WES	3.22	1	4,500	1	NBS_followup	2,978.83	6.95	Regression	43.9	74.4	105.7	47.7	51.7	0	0	0	2.9	5	1	Mild	1	63.2	1	1	1	0	1	0	1	1	1	-1.66	-2.02	1	0	1	0	26.64	60.564	15.481	0.96	6.79	131	1.33	0.149	476.6	598.2	27.4	586.1	999.7	1	ERT	Avalglucosidase_alfa	null	null	null	0.21	70.41	447,246	Fully_covered	0	0	8.43	1	11,827	Cost_saving	0.425	0.519	0	0	Non_responder	0	null	0	0	Rapid	6	60	0	0	1	Wheelchair	AAC_device	1	0	Home_school_medical	1	0	1	16.95	Other	0	68.5	7.9	14.8	1	17,202	5.7	14,913	50	52.9	57.3	66.4	52.5	44.9	0	0	1	1	0	1	0	122.8	15	1	0	0	0	0	1	1	2.38
HCG5-0000231	Male	Black_non_Hispanic	North_America	Suburban	Low	English	TRICARE	CPS1	UCD	147	237,300	AR	7.3	0.62	0.161	0.637	0.476	2	5	26	1	1	0	0	null	WGS	18.47	0	8,500	1	Other	121,416.55	4.66	Regression	69.6	68.1	52.8	10	63	0	0	0	1.75	0	0	null	0	120.8	0	0	1	1	1	0	0	0	0	-2.22	1.8	1	0	0	1	355.71	23.124	3.906	0.81	2.53	311.5	1.98	0.174	871.5	352.7	36	277	813	1	Supportive_only	null	null	null	null	null	16.95	0	Fully_covered	0	0	36	0	360	Intermediate	0.504	null	0	0	Not_applicable	0	null	0	0	Slow_progression	3	12	2	1	0	Wheelchair	AAC_device	0	0	Mainstream_with_support	1	5	1	9.94	Respiratory_failure	0	63.1	10.9	12	1	40,175	5.4	21,175	51.1	46.5	50	44.5	41.7	57.4	0	1	1	1	0	1	0	40.3	7	0	0	0	0	0	0	1	0.19
HCG5-0000232	Male	White_non_Hispanic	Asia_Pacific	Urban	Middle	English	Commercial	22q11_2_DiGeorge	SYN	567	188,400	AD	5.99	0.08	0.156	5.874	5.718	0	10	12	2	1	0	0	null	WGS	19.6	0	8,500	1	Geneticist	6,153.04	8.11	Delayed	51.7	50	58.8	76.9	103.9	1	1	0	2.85	7	1	Moderate	0	65.1	0	0	0	0	0	0	0	0	0	-2.93	0.91	0	0	0	0	307.49	19.506	18.914	1.01	0.72	20	1.19	0.158	170.1	258.9	22.5	498.7	10,641.4	0	Small_molecule	null	null	null	Supportive_metabolic	6.88	2.98	1,361,851	Prior_auth_required	0	0	14.18	0	3,799	High_value	0.303	0.603	0	0	Responder	0	null	0	0	Stable	4	18	0	0	0	Assisted	Limited_verbal	0	0	Special_ed	1	0	0	null	null	0	69	13.5	5.5	1	10,466	5.2	4,576	33.8	48.1	46.4	59.4	63.7	21.6	1	0	1	1	1	0	0	159	12	1	0	1	0	0	0	1	3.68
HCG5-0000233	Male	Hispanic	North_America	Rural	Low	English	Commercial	SMA_type2	NM	83,418	253,550	AR	5.26	0.25	0.003	0.003	0	0	5	11	1	0	1	1	1	WES	6.94	1	4,500	1	NBS_followup	9,136.74	6.75	Delayed	66.1	64.5	61.4	87.7	119.6	0	0	0	3.37	8	0	null	1	61.1	1	0	0	0	0	0	1	0	0	-2.17	-0.1	0	0	1	0	41.08	15.049	31.22	1.51	2.22	88.8	4.01	0.189	728.3	158.8	38.6	236	1,636.5	1	Supportive_only	null	null	null	null	null	10.6	0	Fully_covered	0	0	5.16	0	55	High_value	0.362	null	0	0	Not_applicable	0	null	0	0	Slow_progression	2	17	4	0	1	Assisted	Limited_verbal	0	0	Home_school_medical	1	0	1	6.37	Cardiac	0	44.1	15.7	14	0	0	5.7	59,016	44.2	51.1	40.1	51.3	43.2	33.1	0	0	0	0	0	0	1	201.8	10	1	0	0	0	1	0	10	0.52
HCG5-0000234	Male	White_non_Hispanic	Latin_America	Suburban	Low	English	Medicaid	Angelman	SYN	72	105,830	AD	4.94	0.08	1.228	11.58	10.352	2	12	17	4	1	0	0	null	WES	4.18	0	4,500	1	Geneticist	35,212.32	5.11	Delayed	79.9	47	75.4	69.4	67.5	0	1	1	1.08	3	0	null	0	53.5	0	0	0	0	0	0	0	0	0	-2.22	1.07	0	0	0	0	217.08	19.734	16.31	2.45	1.42	175.2	5.38	0.171	106.6	418.9	61.8	72.7	391.1	0	Supportive_only	null	null	null	null	null	7.86	0	Fully_covered	0	0	1.45	0	1,759	Low_value	0.46	null	0	0	Not_applicable	0	null	0	0	Stable	0	40	2	1	0	Assisted	Limited_verbal	0	0	Mainstream_with_support	1	1	0	null	null	0	32.3	8.7	12.2	1	23,897	7.2	2,579	70.9	73.6	53	76.6	40.5	49.6	1	0	1	1	0	0	1	34.5	21	0	0	0	0	0	0	0	0
HCG5-0000235	Male	White_non_Hispanic	Asia_Pacific	Rural	Middle	English	Other_public	SCID	IMM	183	300,400	XLR	9.5	0.92	0.003	0.003	0	0	2	14	6	0	1	1	1	WGS	0.92	0	8,500	0	NBS_followup	46,950.23	7.88	Profound_delay	53.5	14.7	10	73	35	0	0	0	1.15	4	1	Moderate	0	114.9	0	0	0	1	0	0	0	0	0	-1.75	-0.01	0	0	0	0	337.13	20.255	2.975	3.12	1.04	20	0.85	0.146	141.2	423.3	30.7	34.3	4,792.4	1	ASO	null	null	Custom_ASO	null	1.28	5.5	186,721	Denied	0	0	11.88	1	14,837	Intermediate	0.412	0.855	0	0	Responder	1	MUD	1	0	Stable	3	23	2	0	0	Bedbound	Nonverbal	1	1	Mainstream	1	0	1	2.37	Cardiac	1	47	15	15.1	1	38,142	5	1,831	36.3	15.1	67.6	57.4	26.1	24.5	0	1	0	1	0	0	1	53.7	5	1	0	0	0	0	0	2	0
HCG5-0000236	Male	White_non_Hispanic	Latin_America	Urban	Low	Other	Medicaid	Leigh_syndrome	MITO	506	256,000	MT	7.27	0.68	2.136	6.93	4.794	2	12	10	2	1	0	0	null	WES	1.64	0	4,500	1	Neurologist	20,846.75	4.63	Regression	58.5	56.5	84.9	78.4	40.1	1	0	1	2.42	3	1	Moderate	1	52.6	1	1	1	1	0	1	1	1	0	-2.1	-0.39	0	0	0	0	36.44	16.651	4.792	4.25	9.61	302.9	2.55	0.154	286	596.2	24.2	97.7	533.4	0	Supportive_only	null	null	null	null	null	14.09	0	Fully_covered	0	0	3.63	0	5,680	Intermediate	0.663	null	0	0	Not_applicable	0	null	0	0	Stable	2	14	1	0	0	Wheelchair	AAC_device	0	0	Mainstream	1	3	0	null	null	1	74.9	12.1	6.4	1	45,981	6.3	3,496	47.2	31	52.6	87.1	30.4	44.9	0	0	0	1	0	0	1	543.9	17	0	1	0	1	1	0	1	6.52
HCG5-0000237	Male	White_non_Hispanic	North_America	Urban	Middle	English	Commercial	Hypophosphatasia	SKEL	436	241,500	AR	6.35	0.25	0.01	1.231	1.221	1	15	21	2	1	0	0	null	WES	19.27	0	4,500	1	Geneticist	60,074.78	5.17	Regression	39.3	86.4	76.2	67.9	122.3	0	0	0	2.31	1	0	null	0	55.1	0	0	1	0	0	1	0	0	1	-1.6	-1.36	0	1	0	0	241.12	18.31	10.898	4.36	6.84	174.4	1.4	0.165	678.6	568.2	32.4	279.8	7,049.8	1	Small_molecule	null	null	null	Supportive_metabolic	4.73	1.26	1,816,331	Partial_coverage	0	0	12.11	1	1,641	Intermediate	0.297	0.767	0	0	Partial	0	null	0	0	Slow_progression	7	11	2	1	0	Wheelchair	AAC_device	1	0	Special_ed	1	6	0	null	null	0	35.3	11.3	13.2	0	0	2.6	8,796	64.9	64.6	48.3	62.5	82.2	25.7	0	0	1	1	1	0	0	67.8	30	0	0	0	0	0	0	2	0
HCG5-0000238	Male	White_non_Hispanic	Europe	Urban	Middle	English	Commercial	Gaucher_type1	LSD	355	230,800	AR	5.1	0.05	3.783	6.336	2.553	0	6	8	4	0	0	0	null	Single_gene	25.74	1	800	0	Neurologist	13,135.86	6.5	Delayed	33.2	70.3	50.8	64.7	73.3	0	1	0	2	7	0	null	0	59.9	0	0	0	1	0	1	1	1	1	-1.86	-0.98	0	0	1	0	92.29	7.589	9.732	4.31	1.39	20	2.31	0.081	126.9	1,026.3	96.8	66.6	1,779	1	ERT	Taliglucerase	null	null	null	6.39	58.17	539,365	Prior_auth_required	0	0	6.4	1	213	High_value	0.517	0.706	0	0	Responder	0	null	0	0	Slow_progression	0	18	1	0	0	Assisted	Limited_verbal	0	0	Special_ed	0	1	0	null	null	0	43.7	12.5	14.6	1	82,402	5.2	15,465	61.5	53.4	36.6	41.6	60.6	25.7	0	0	0	1	1	0	0	185.7	15	0	0	0	0	0	0	4	0
HCG5-0000239	Male	White_non_Hispanic	Asia_Pacific	Urban	Middle	English	Medicaid_CHIP	Fabry	LSD	324	301,500	XLR	5.34	0.04	11.483	15.02	3.537	1	5	22	1	1	0	0	null	Panel	4.07	0	1,500	1	Neurologist	18,774.92	5.83	Delayed	61.9	103.2	63.3	58.7	93.6	0	0	0	1.17	6	1	Moderate	1	72.9	1	0	1	0	0	0	0	0	0	-0.82	-1.14	0	0	1	0	311.75	13.312	9.911	11.19	1.06	341.4	2.11	0.249	563.5	273	96.2	721.4	505.8	1	Gene_therapy	null	Clinical_trial	null	null	17.78	19.55	5,000,000	Fully_covered	0	0	9.66	1	1,271	High_value	0.467	0.591	0	0	Responder	0	null	0	0	Slow_progression	4	21	1	0	1	Assisted	Limited_verbal	0	0	Home_school_medical	1	1	1	18	Respiratory_failure	1	63.3	21.6	3.6	1	54,049	6.7	13,268	56.7	74.9	74.7	34	38.1	64	1	1	1	1	0	0	0	135.7	10	0	0	1	0	0	1	3	5.26
HCG5-0000240	Male	Hispanic	North_America	Urban	Low	Other	Medicaid	WAS_Wiskott	IMM	906	301,000	XLR	6.24	0.55	0.454	5.034	4.58	0	11	24	3	0	0	0	null	Panel	46.3	0	1,500	1	Metabolic_specialist	20,498.97	7.26	Regression	76.9	58.2	44.6	70.1	79.1	0	1	0	1.63	4	1	Mild	0	51.4	0	0	0	1	0	1	0	0	0	0.1	-0.38	1	0	0	0	71.26	5.272	9.6	1.17	3.03	20	1	0.19	322.9	436.1	32	81.4	4,110.6	1	Supportive_only	null	null	null	null	null	1.32	0	Partial_coverage	0	0	14.97	0	726	Cost_saving	0.134	null	1	0	Not_applicable	0	null	0	0	Stable	1	10	0	0	0	Wheelchair	AAC_device	0	0	Special_ed	1	0	0	null	null	0	48.1	17.6	7.5	0	0	7	4,277	49.9	48.5	90.1	59.4	67.8	51.6	0	0	0	1	0	1	0	181.6	15	0	1	0	1	1	0	10	6.81
HCG5-0000241	Male	White_non_Hispanic	North_America	Urban	High	English	Medicaid	Diastrophic	SKEL	628	222,600	AR	5.67	0.1	0.015	0.723	0.708	1	19	15	1	0	0	0	null	Panel	5.37	0	1,500	1	Other	16,571.57	6.23	Delayed	71.2	65.4	66.6	60.5	115.7	0	0	0	1.39	3	0	null	1	61.1	0	0	1	0	0	0	1	0	1	-1.82	-3.43	0	0	0	0	514.01	32.233	2.402	5.85	1.01	20	4.6	0.129	366.6	258.8	63.8	39.8	3,044.8	0	Supportive_only	null	null	null	null	null	19.3	0	Partial_coverage	0	0	1.41	0	1,434	Intermediate	0.436	null	0	0	Not_applicable	0	null	0	0	Slow_progression	1	33	3	0	1	Assisted	Limited_verbal	0	0	Special_ed	1	2	0	null	null	0	41.1	19	2.8	1	50,209	4.5	18,456	70.3	55.9	44.6	10.9	76.1	46	0	0	1	1	1	0	0	163.7	15	1	0	0	0	0	0	5	0
HCG5-0000242	Female	White_non_Hispanic	North_America	Urban	Low	Other	Commercial	MPS_III_Sanfilippo	LSD	581	252,900	AR	8.98	0.7	2.104	5.795	3.691	0	7	16	3	0	0	0	null	Metabolic	7.83	0	900	0	Geneticist	4,718.47	3.98	Profound_delay	46	25.5	38.4	52.1	42.5	0	0	1	0.46	0	0	null	1	45.6	0	0	0	1	1	0	1	1	1	-2.55	1.25	0	0	1	1	142.09	23.856	25.156	5.83	2.67	95.3	2.03	0.209	87.7	581.2	44.1	244.9	216.3	0	Supportive_only	null	null	null	null	null	16.24	0	Fully_covered	0	0	7.51	0	47	High_value	0.404	null	0	0	Not_applicable	0	null	0	0	Moderate	4	11	2	1	0	Bedbound	Nonverbal	1	0	Special_ed	1	2	0	null	null	0	59.8	15.9	7.2	0	0	6.1	3,572	35.6	34.8	41.9	42.1	26.8	45.1	0	0	0	1	0	0	0	2.7	31	0	1	0	0	0	0	1	3.64
HCG5-0000243	Male	White_non_Hispanic	MENA	Urban	Middle	English	Commercial	Alpers	MITO	726	203,700	AR	6.97	0.75	2.955	9.882	6.928	5	6	10	0	1	0	0	null	Panel	12.42	0	1,500	1	Geneticist	26,312.51	6.24	Regression	54.6	50.2	56	66.5	35.2	0	0	1	1.7	1	0	null	0	83.7	0	0	0	0	0	0	1	1	0	-3.52	2.71	0	0	0	0	98.01	19.879	21.424	1.63	3.54	157.3	1.68	0.135	154.2	229.6	109.8	565	1,696.9	0	Small_molecule	null	null	null	Supportive_metabolic	10.4	49.99	165,912	Fully_covered	0	0	6.58	1	2,330	Low_value	0.331	0.804	0	0	Responder	0	null	0	0	Stable	10	19	1	0	0	Wheelchair	AAC_device	0	0	Special_ed	1	0	1	18	Infection	0	40.9	23.7	10.2	1	36,645	6.7	110,089	58.2	71.9	40.6	42.9	41.1	55.6	0	1	0	1	0	1	0	30.5	7	1	0	0	0	0	0	4	0
HCG5-0000244	Male	White_non_Hispanic	Asia_Pacific	Urban	Middle	English	Medicaid	SMA_type3	NM	83,419	253,400	AR	4.76	0.04	6.128	14.828	8.7	4	6	6	3	1	1	0	null	WES	54.28	0	4,500	1	Metabolic_specialist	24,257.8	7.47	Delayed	74.6	47.9	45.1	64.7	113.3	0	1	0	6.93	5	0	null	1	40.2	0	0	0	0	0	0	0	0	0	-1.02	-1.09	0	0	0	0	88.01	49.285	19.495	6.87	4.37	42	2.39	0.135	218.7	576.4	51.1	1,263.7	2,437.8	1	Small_molecule	null	null	null	Supportive_metabolic	15.38	66.45	930,498	Denied	0	0	8.66	0	631	Intermediate	0.739	0.742	0	0	Responder	0	null	0	0	Stable	4	23	0	0	0	Assisted	Limited_verbal	0	0	Special_ed	1	6	0	null	null	0	52.5	17.8	3	1	21,697	4.8	17,574	53	69	78	43.4	53.3	41.2	1	1	1	1	1	0	1	39.2	5	1	0	0	0	0	0	0	0
HCG5-0000245	Male	White_non_Hispanic	Europe	Urban	Middle	English	Commercial	EB_simplex	DERM	304	131,800	AD	3.64	0.04	0.016	0.281	0.265	1	15	8	7	0	0	0	null	null	4.67	1	0	0	Metabolic_specialist	70,994.98	8.75	Delayed	58.4	48.1	64.4	97.2	98.8	0	0	0	5.58	7	1	Moderate	0	67	0	0	1	0	0	1	0	0	0	-2.88	1.48	0	0	0	0	434.42	10.204	17.935	6.04	4.51	20	1.32	0.192	366.9	252.6	38.8	41.6	2,299.7	0	Supportive_only	null	null	null	null	null	72	0	Fully_covered	0	0	10.53	0	6,131	High_value	0.651	null	0	0	Not_applicable	0	null	0	0	Slow_progression	1	18	0	0	0	Ambulatory	Verbal	0	0	Home_school_medical	1	2	0	null	null	0	11.1	3.5	15.5	1	40,820	3.8	800	70.5	32.3	84.5	64.7	39	35.9	0	0	0	1	0	0	1	75.3	16	0	0	1	0	0	0	1	0.47
HCG5-0000246	Male	Black_non_Hispanic	Asia_Pacific	Urban	Low	English	Medicaid	SMA_type3	NM	83,419	253,400	AR	4.65	0.04	0.028	0.028	0	0	3	12	10	0	1	1	10.2	WES	1.48	1	4,500	1	NBS_followup	8,456.16	6.38	Delayed	83.8	48.9	91.5	65.4	83.1	0	0	0	1.87	8	0	null	0	77.3	0	0	0	0	1	0	0	0	0	1.02	-0.61	0	0	0	0	87.96	11.708	9.434	4.33	1.64	25.4	1.99	0.293	92.9	535.5	137	1,171.5	1,503.1	1	Gene_therapy	null	Onasemnogene_abeparvovec	null	null	0.27	7.35	2,392,660	Prior_auth_required	0	0	7.67	0	103	Cost_saving	0.283	0.63	0	0	Responder	0	null	0	0	Stable	5	21	1	0	0	Assisted	Limited_verbal	0	1	Mainstream_with_support	1	1	0	null	null	0	21.2	16.8	15.8	1	51,910	4.2	3,688	69.5	64.3	65.6	39	42.5	65.5	0	0	1	1	0	0	0	20.7	20	1	0	0	0	0	0	1	0.26
HCG5-0000247	Male	White_non_Hispanic	Europe	Suburban	Low	Mandarin	Commercial	CPS1	UCD	147	237,300	AR	9.37	0.62	0.01	1.735	1.725	4	15	10	8	1	0	0	null	Panel	23.92	0	1,500	0	Other	15,131.49	5.25	Profound_delay	54.3	43.5	23.2	39.5	79.4	0	0	0	3.78	2	1	Severe	1	67.6	1	0	0	1	1	0	0	0	0	1.54	-1.36	0	0	1	0	523.45	5.853	7.054	0.65	3.54	21.5	0.74	0.185	51.9	667.3	23.4	300	3,808.5	1	Small_molecule	null	null	null	Supportive_metabolic	2.31	18.08	251,297	Partial_coverage	0	0	3.73	0	11,134	Cost_saving	0.534	0.675	0	0	Partial	0	null	0	0	Slow_progression	1	24	2	1	0	Bedbound	Nonverbal	1	1	Mainstream_with_support	1	5	1	12.32	Neurodegeneration	0	46.2	15.8	10.7	1	19,163	3.9	2,819	48.5	58.4	30.7	17.7	30.7	42.6	0	0	0	1	0	1	0	48.5	15	1	1	0	0	1	0	2	5.92
HCG5-0000248	Female	Asian	Europe	Urban	Middle	Other	Medicaid	HCU_homocystinuria	OA	394	236,200	AR	5.29	0.08	0.003	0.003	0	0	2	5	2	0	1	1	1	Metabolic	1.95	0	900	0	NBS_followup	79,470.57	6.98	Delayed	59.2	53.2	10	47.1	80.6	0	0	0	3.63	1	0	null	1	48.6	0	0	0	0	1	0	0	0	0	-2.06	-1.01	1	1	1	0	224.4	55.741	4.875	9.69	10.51	118.8	0.54	0.121	20	167.8	55.9	123.6	3,193.7	0	Supportive_only	null	null	null	null	null	5.88	0	Partial_coverage	0	0	2.42	0	647	Intermediate	0.554	null	0	0	Not_applicable	0	null	0	0	Rapid	8	12	3	0	0	Assisted	Limited_verbal	0	0	Home_school_medical	1	4	0	null	null	0	64.9	16.3	7	0	0	6.6	49,978	75.6	49.3	68.8	68.1	48.5	70.7	0	0	1	1	1	0	1	13.7	9	1	1	0	0	0	0	3	3.89
HCG5-0000249	Female	Asian	Europe	Urban	Low	English	Medicaid	ASL	UCD	23	207,900	AR	8.6	0.42	0.701	2.135	1.433	1	25	5	6	0	0	0	null	Panel	20.19	1	1,500	1	Geneticist	35,030	4.89	Profound_delay	52	37.2	36.7	39	84.7	0	1	0	2.18	1	0	null	0	97.3	0	0	0	0	0	0	1	0	0	-3.8	-0.26	1	1	1	0	45.35	38.282	48.844	5.37	0.5	20.7	1.24	0.144	598.8	186.1	116.3	517.4	1,865.2	1	SRT	null	null	null	null	2.36	29.26	1,481,344	Partial_coverage	0	0	1.6	1	154	High_value	0.446	0.403	0	0	Non_responder	0	null	0	0	Moderate	4	52	4	1	0	Bedbound	Nonverbal	1	0	Home_school_medical	1	0	1	7.79	Cardiac	1	46.6	4.6	10.9	1	7,933	5.9	2,363	60.9	54	59.3	43.6	100	43	1	0	1	1	0	1	0	5.9	17	1	0	0	0	1	0	7	1.64
HCG5-0000250	Male	White_non_Hispanic	Europe	Urban	Low	Other	Medicaid	Congenital_myopathy	NM	97,245	160,150	AR	7.45	0.18	1.131	5.202	4.071	0	16	5	1	0	0	0	null	Single_gene	23.61	0	800	1	Cardiologist	44,110	9.07	Regression	20.7	61.6	98.5	92.6	62.2	1	0	0	6.35	6	1	Mild	1	49.7	0	0	0	0	0	0	1	0	0	-1.02	-1.55	0	0	1	0	186.04	73.452	11.96	6.19	4.45	20	1.62	0.232	759.7	410.5	71.3	1,086.7	1,427.4	0	Supportive_only	null	null	null	null	null	0.93	0	Partial_coverage	0	0	7.45	0	8,471	Intermediate	0.222	null	0	0	Not_applicable	0	null	0	0	Rapid	2	61	1	0	1	Wheelchair	AAC_device	1	0	Special_ed	1	6	0	null	null	0	47.2	4.5	18.2	1	100,141	5.3	632	46.1	69.5	63.4	60.2	26.5	63	0	1	0	1	0	1	1	1,047.4	15	1	1	0	0	1	0	6	3.46
HCG5-0000251	Male	White_non_Hispanic	North_America	Suburban	Middle	English	Commercial	EB_simplex	DERM	304	131,800	AD	5.59	0.04	0.146	0.311	0.165	1	24	9	0	1	0	0	null	Panel	6.33	0	1,500	1	Other	40,460.86	6.61	Delayed	66.9	35.9	78.7	46.6	87.4	0	1	1	7.64	0	0	null	1	68.4	1	0	0	0	0	0	0	0	0	0.72	0.57	0	0	0	0	189.97	92.233	2.733	0.3	1.15	20	0.78	0.194	21.9	389.3	26.2	38.6	2,096.7	0	Small_molecule	null	null	null	Supportive_metabolic	2.21	2.45	93,566	Partial_coverage	0	0	10.74	0	17,860	High_value	0.249	0.792	0	0	Responder	0	null	0	0	Moderate	0	38	0	0	1	Assisted	Limited_verbal	0	0	Special_ed	1	3	0	null	null	0	50	12.1	13.5	0	0	4.7	16,605	59.8	47.1	41	61.1	18.7	53.6	0	0	1	0	1	0	1	34	29	1	0	0	1	0	0	2	2.02
HCG5-0000252	Male	White_non_Hispanic	Latin_America	Urban	High	English	Medicaid_CHIP	Leigh_syndrome	MITO	506	256,000	MT	8.98	0.68	0.01	1.188	1.178	1	13	20	0	1	0	0	null	Panel	59.61	0	1,500	1	Metabolic_specialist	40,622.79	4.34	Profound_delay	39.2	45.8	24.8	49.9	59.5	0	0	0	1.51	1	0	null	0	97.1	0	0	1	1	0	0	0	1	0	-3.37	-1.23	0	0	0	0	43.9	15.151	11.866	2.93	11.75	20	1.65	0.243	268	315.4	25.2	152.3	988.6	0	Supportive_only	null	null	null	null	null	6.19	0	Partial_coverage	0	0	4.91	0	4,657	Intermediate	0.515	null	0	0	Not_applicable	0	null	0	0	Stable	1	29	2	0	0	Bedbound	Nonverbal	1	0	Mainstream_with_support	1	5	1	10.22	Other	1	43.4	3.2	2.2	1	9,333	7.1	339	52.1	45.8	32.9	60.7	64.1	61.2	0	0	0	1	0	1	1	222	12	0	0	0	0	0	0	3	1.43
HCG5-0000253	Male	Black_non_Hispanic	Asia_Pacific	Suburban	Low	English	Commercial	MPS_VI_Maroteaux	LSD	583	253,200	AR	8.32	0.32	0.472	3.753	3.281	1	10	23	4	1	0	0	null	WGS	9.86	0	8,500	1	Geneticist	138,544.24	6.17	Profound_delay	68.6	64.5	40.7	37.3	44.6	0	0	0	3.42	4	0	null	1	43.1	0	1	1	0	1	0	1	1	1	0.48	-2.12	0	0	1	1	182.78	11.704	1.867	1.42	6.93	31	1.62	0.193	155.6	287.7	16.7	134.4	650.3	1	Small_molecule	null	null	null	Supportive_metabolic	4.44	9.33	97,505	Prior_auth_required	0	0	14.12	0	3,073	Low_value	0.511	0.624	0	0	Partial	0	null	0	0	Stable	0	11	3	0	0	Bedbound	Nonverbal	1	1	Special_ed	1	4	0	null	null	0	26.1	17.7	0	0	0	5.5	4,235	66.2	31.4	24.5	55.8	48.2	56.3	0	0	0	1	0	0	0	146.7	9	0	0	0	0	0	0	5	0.2
HCG5-0000254	Female	White_non_Hispanic	North_America	Rural	High	English	Medicaid_CHIP	MPS_IV_Morquio	LSD	582	253,000	AR	6.96	0.3	2.533	11.874	9.34	4	8	19	2	1	0	0	null	Panel	8.64	0	1,500	1	Metabolic_specialist	29,213.51	6.25	Regression	51.2	74.6	65.5	12.7	55.1	0	0	0	2.77	6	0	null	0	67	0	0	0	0	0	0	0	0	1	-4.02	-0.43	0	0	1	1	311.74	4.411	15.229	12.61	6.73	20	2.14	0.225	1,054.1	238	126.2	487.2	587.7	1	Small_molecule	null	null	null	Supportive_metabolic	12.76	11.94	186,849	Prior_auth_required	0	0	6.03	0	1,053	Cost_saving	0.369	0.753	0	0	Partial	0	null	0	0	Moderate	0	38	0	1	0	Wheelchair	AAC_device	0	0	Home_school_medical	1	5	0	null	null	0	57.2	14	6.2	0	0	6.2	13,550	26.2	55.7	80	66.2	40.8	62	0	0	1	1	0	0	0	34.6	5	1	0	1	0	0	0	4	2.8
HCG5-0000255	Male	Hispanic	Europe	Urban	Middle	Mandarin	Medicaid	OI_type1_to_4	SKEL	666	166,200	AD	3.5	0.06	0.01	2.857	2.847	0	22	5	4	0	0	0	null	WGS	42.42	0	8,500	0	Geneticist	10,826.92	3.97	Delayed	92.9	88.1	38.6	87.9	71.1	0	0	0	4.34	0	1	Moderate	0	109	0	0	0	0	0	0	0	0	1	-3.55	-1.51	0	0	0	1	560.12	8.263	13.855	1.85	1.54	20	3.22	0.37	190.1	430.8	20.2	1,219.3	1,636	1	Chaperone	null	null	null	null	3.45	40.52	86,037	Fully_covered	0	0	6.19	1	2,955	Intermediate	0.657	0.706	0	0	Responder	0	null	0	0	Moderate	4	12	2	1	0	Ambulatory	Verbal	0	0	Special_ed	1	2	0	null	null	1	48.5	23.7	9.7	1	29,320	4.7	4,116	80.4	36.6	87.5	96.1	75.3	71.1	0	0	1	0	0	0	0	292.4	12	1	0	0	0	0	0	3	0.7
HCG5-0000256	Male	Hispanic	North_America	Rural	High	English	Medicaid	SCID	IMM	183	300,400	XLR	8.05	0.92	0.019	0.019	0	0	2	7	1	0	1	1	6.8	Single_gene	0.59	0	800	0	NBS_followup	47,806.54	7.69	Profound_delay	40.6	49.1	25.7	37.1	59.2	0	0	0	0.53	1	0	null	1	37.1	0	0	0	1	0	0	0	0	0	-1.43	-0.92	0	0	0	0	536.11	16.57	7.48	14.63	4.21	144.3	6.22	0.096	470.9	225.4	73.7	265.3	766.8	1	Chaperone	null	null	null	null	0.14	4.88	182,949	Fully_covered	0	0	1.83	0	5,793	High_value	0.689	0.687	0	0	Partial	1	MSD	1	1	Moderate	10	36	0	0	0	Bedbound	Nonverbal	1	0	Mainstream_with_support	1	1	1	7.12	Cardiac	1	53.2	15.7	2.5	0	0	4.4	25,209	21.8	55.1	25.1	58.8	18	37.4	1	0	1	0	0	0	0	20.5	23	0	0	0	0	0	0	1	1.13
HCG5-0000257	Male	Hispanic	MENA	Suburban	Middle	English	Medicaid	Fabry	LSD	324	301,500	XLR	4.75	0.04	6.412	18	14.692	1	14	25	3	1	0	0	null	MLPA	15.18	1	1,000	1	Neurologist	16,156.92	6.63	Delayed	28	58.7	75.1	75.2	62.4	1	0	0	3.18	8	1	Mild	1	66	0	0	0	0	1	1	1	1	1	-0.58	-0.49	0	1	0	0	1,976.4	3.473	5.23	9.6	4.65	20	2.88	0.433	146.9	438.4	16.5	177.4	1,542.6	1	ASO	null	null	Custom_ASO	null	18	2.41	73,521	Prior_auth_required	0	0	4.49	0	1,262	Low_value	0.687	0.689	0	0	Responder	0	null	0	0	Stable	0	63	0	0	1	Assisted	Limited_verbal	1	0	Mainstream	1	5	0	null	null	0	30.2	16.6	9.2	0	0	7	9,005	66	82.5	47.3	70.6	60.1	72.6	0	0	1	1	0	1	0	50.3	10	1	0	0	0	0	0	1	0.86
HCG5-0000258	Male	Black_non_Hispanic	Latin_America	Urban	Middle	English	Uninsured	Gaucher_type2_3	LSD	77,259	230,900	AR	7.9	0.72	0.01	5.271	5.261	2	14	3	1	1	0	0	null	Single_gene	5.35	0	800	1	Metabolic_specialist	24,368.75	6.65	Regression	44.6	49.5	78.2	67.5	63.8	1	0	1	2.01	2	0	null	1	55.7	1	0	1	0	0	0	0	0	1	-1.88	-2.54	0	0	0	0	181.38	8.418	20.21	5.35	0.39	20	1.23	0.24	107.3	273.9	267.7	399.4	6,836.9	1	HSCT	null	null	null	null	7.66	6.51	98,701	Fully_covered	0	0	15.31	1	812	High_value	0.687	0.685	0	0	Responder	0	null	0	0	Stable	1	25	2	0	0	Wheelchair	AAC_device	1	0	Special_ed	1	5	0	null	null	0	69.7	16.8	2.6	0	0	5.9	2,440	58	24.7	41.1	54.7	41.1	46.6	0	1	0	1	1	0	0	106.9	4	1	0	0	0	1	1	2	3.36
HCG5-0000259	Male	Other_Multi	Latin_America	Urban	Middle	English	Medicaid	SMA_type2	NM	83,418	253,550	AR	7.43	0.25	0.003	0.003	0	0	4	10	2	0	1	1	1	MLPA	12	0	1,000	0	NBS_followup	37,540.02	9.33	Regression	55.3	85.4	38.8	56.2	65.8	0	0	0	3.76	1	1	Moderate	1	44.8	1	1	0	1	0	1	0	0	0	-1.26	1.93	1	0	0	0	315.39	20.603	11.305	11.12	3.79	329.4	3.32	0.472	614.4	295.5	17.3	189.1	1,469.9	1	Supportive_only	null	null	null	null	null	5.12	0	Prior_auth_required	0	0	23.52	0	1,614	Cost_saving	0.417	null	0	0	Not_applicable	0	null	0	0	Rapid	1	78	1	1	0	Wheelchair	AAC_device	0	0	Special_ed	1	0	0	null	null	0	41.9	13.7	10.9	1	33,648	6	7,560	47.7	70.5	74.4	15.7	47.2	22	0	0	0	1	0	1	1	56.6	20	1	0	0	0	0	0	6	0.16
HCG5-0000260	Female	White_non_Hispanic	North_America	Suburban	Middle	English	Other_public	Pompe_infantile	LSD	365	232,300	AR	8.03	0.85	0.011	0.011	0	0	4	8	5	0	1	1	4	Single_gene	11.09	0	800	1	NBS_followup	12,845.91	7.45	Profound_delay	50.5	55.4	76.7	54	57.9	0	0	0	2.13	6	1	Mild	1	64.4	0	0	1	1	0	0	0	1	1	-0.47	0.9	0	0	1	0	98.87	49.605	2.122	2.11	5.77	120.1	5.16	0.112	892.5	670.4	46.1	22.5	2,075.9	1	SRT	null	null	null	null	0.33	18.33	505,553	Fully_covered	0	0	5.63	0	3,546	Low_value	0.18	0.731	0	0	Responder	0	null	0	0	Stable	2	21	2	0	0	Bedbound	Nonverbal	0	0	Special_ed	0	0	1	4.09	Cardiac	0	68.5	14.1	12.1	1	147,468	6.2	34,837	60.3	41.6	57.6	49.5	46	62.4	0	0	1	0	0	0	0	45.9	10	1	0	0	1	0	0	2	1.55
HCG5-0000261	Male	White_non_Hispanic	North_America	Rural	High	Spanish	Medicaid	WAS_Wiskott	IMM	906	301,000	XLR	9.91	0.55	0.701	5.26	4.559	0	5	13	6	0	0	0	null	Karyotype	9.87	0	1,200	1	Geneticist	16,996.02	7.74	Profound_delay	38.6	36.5	14.8	19.1	47.4	0	0	0	4.56	2	0	null	0	118.1	0	0	1	1	0	0	0	0	0	-0.34	-1.41	0	0	0	0	1,193	11.642	35.999	2.43	0.93	153.8	1.14	0.193	53.4	588.3	104.4	432.1	1,438.4	1	Small_molecule	null	null	null	Supportive_metabolic	8.11	53.38	375,977	Fully_covered	0	0	14.59	0	9,861	Intermediate	0.362	0.699	0	0	Partial	0	null	0	0	Rapid	1	25	0	1	0	Bedbound	Nonverbal	1	0	Mainstream	1	2	1	11.7	Metabolic_crisis	1	20.4	13.6	20	1	27,084	7	7,777	23.8	23.9	81.5	75	92.7	66.2	1	0	1	1	0	0	0	6.4	21	1	0	0	0	0	0	2	0.94
HCG5-0000262	Male	White_non_Hispanic	North_America	Urban	Low	English	Medicaid	MMA	OA	27	251,000	AR	7.38	0.45	0.015	0.015	0	0	2	15	0	0	1	1	5.5	WGS	1.85	0	8,500	1	NBS_followup	41,285.38	5.42	Regression	42.9	65	10	65.5	44.8	1	1	0	1.12	3	0	null	1	68.8	1	1	0	1	0	0	0	0	0	-2.55	-0.43	1	1	0	0	74.37	24.908	5.229	9.37	5.71	74.2	1.17	0.176	963.8	221.7	27.3	723.6	6,677.6	0	Supportive_only	null	null	null	null	null	48.35	0	Fully_covered	0	0	23.88	0	6,825	High_value	0.399	null	0	0	Not_applicable	0	null	0	0	Slow_progression	8	40	2	0	1	Wheelchair	AAC_device	0	0	Special_ed	1	2	1	13.94	Infection	1	41.9	0	10.2	1	282,588	7.2	10,311	37.2	40.1	51.7	63.4	35.5	58.9	0	0	0	1	1	0	1	127.3	8	0	0	0	1	0	0	2	2.52
HCG5-0000263	Male	Asian	North_America	Urban	Low	English	Medicaid	Pompe_infantile	LSD	365	232,300	AR	8.99	0.85	0.421	1.863	1.442	2	10	22	2	0	1	0	null	WES	11.08	0	4,500	0	Cardiologist	16,419.41	6.33	Profound_delay	35.7	45.2	52.7	38	41.7	1	0	0	2.21	2	1	Moderate	1	57.8	1	0	0	0	0	0	1	1	1	-2.84	0.62	0	0	1	0	1,140.52	118.793	3.72	2.11	3.63	229.5	0.95	0.235	76	235.9	66.3	797.2	9,488.1	1	Small_molecule	null	null	null	Supportive_metabolic	2.33	33.06	5,000,000	Fully_covered	0	0	2.88	0	8,945	Low_value	0.307	0.734	0	0	Responder	0	null	0	0	Moderate	5	46	0	0	1	Bedbound	Nonverbal	1	1	Home_school_medical	1	5	1	18	Cardiac	1	70.5	20.4	9.5	1	185,634	4.4	9,695	28.4	40.2	28.6	40.5	24	46.8	1	0	1	1	0	0	0	149.4	25	1	0	0	0	0	0	2	0.56
HCG5-0000264	Female	Black_non_Hispanic	North_America	Suburban	Low	English	Medicaid	Rett	SYN	778	312,750	XLD	6.7	0.12	1.244	8.668	7.424	3	16	8	2	1	0	0	null	Single_gene	7.78	1	800	1	Geneticist	64,604.98	5.76	Regression	36.2	62.8	64.5	18.5	24.4	1	0	1	2.38	2	0	null	1	90.7	0	0	0	0	0	0	0	0	1	-0.54	-0.07	0	0	0	0	1,003.19	4.369	41.38	1.55	11.51	126.1	1.59	0.199	20	538.6	36.7	68.6	1,130.6	0	Supportive_only	null	null	null	null	null	5.33	0	Prior_auth_required	0	0	8.9	0	161	Intermediate	0.351	null	0	0	Not_applicable	0	null	0	0	Stable	4	17	2	1	0	Wheelchair	AAC_device	0	1	Special_ed	1	3	0	null	null	0	45.4	19.8	17.3	1	14,722	5.5	2,958	41.3	38.6	44.6	62.6	60.1	35.3	0	0	1	1	1	0	1	32.2	12	1	0	0	1	1	0	0	4.36
HCG5-0000265	Male	Hispanic	North_America	Urban	High	English	Commercial	Pompe_late_onset	LSD	365	232,300	AR	4.3	0.1	0.012	0.012	0	0	2	27	2	1	1	1	4.2	WES	1.24	0	4,500	1	NBS_followup	11,075.14	8.32	Delayed	36.1	68.7	85.4	87.8	72.4	0	0	0	3.94	7	1	Mild	0	51.2	0	0	1	0	0	0	1	1	0	-1.25	2.61	0	1	0	0	82.69	58.985	31.615	3.47	2.29	22.6	2.78	0.191	247.9	178.2	58.7	477.2	3,743.6	1	Small_molecule	null	null	null	Supportive_metabolic	0.63	8.35	83,936	Fully_covered	0	0	7.94	1	2,649	Intermediate	0.212	0.696	0	0	Partial	0	null	0	0	Rapid	5	35	4	0	0	Assisted	Limited_verbal	1	0	Special_ed	1	0	0	null	null	0	11.1	17.5	13.3	1	79,975	4.5	1,156	77.8	76.4	46.1	38.3	76.7	40	0	0	1	1	0	0	0	152.6	13	1	0	0	0	1	1	3	2.48
HCG5-0000266	Male	White_non_Hispanic	Sub_Saharan_Africa	Suburban	Middle	English	Commercial	MMA	OA	27	251,000	AR	7.35	0.45	0.016	0.016	0	0	6	12	1	0	1	1	5.9	WES	1.06	0	4,500	1	NBS_followup	11,041.63	7.44	Regression	50.3	46.6	63.2	73.8	35.7	0	1	0	2.9	4	0	null	0	63.5	0	0	0	1	1	0	1	0	1	-1.09	-0.78	1	1	1	0	510.98	31.271	8.344	2.21	3.9	20	5.42	0.226	449.7	755.2	95.3	1,320.9	14,634.7	0	Supportive_only	null	null	null	null	null	15.91	0	Denied	0	0	17.59	0	1,391	Low_value	0.549	null	0	0	Not_applicable	0	null	0	0	Slow_progression	2	13	5	0	0	Wheelchair	AAC_device	1	0	Not_enrolled	0	3	1	8.97	Other	1	34.4	13.7	11.1	0	0	6	8,964	73.7	39	77.3	67.6	16.9	53.5	0	0	1	1	0	0	1	71.9	15	1	0	0	0	0	0	1	0.56
HCG5-0000267	Male	Other_Multi	North_America	Urban	Middle	Spanish	Medicaid	Pompe_late_onset	LSD	365	232,300	AR	5.53	0.1	5.956	18	15	0	6	20	1	0	1	0	null	WES	2.41	0	4,500	1	Neurologist	149,559.6	2.22	Delayed	50.6	84.6	65.3	92.2	70.1	1	0	0	5.09	8	0	null	0	77.8	0	0	0	0	1	0	0	1	1	-2.59	1.5	0	0	0	0	286.21	69.399	3.946	19.93	4.51	20	3.8	0.158	39.7	390.6	33.1	3,958.7	566.4	1	Chaperone	null	null	null	null	18	4.27	360,399	Fully_covered	0	0	3.15	0	8,374	Low_value	0.713	0.88	0	0	Responder	0	null	0	0	Slow_progression	7	15	2	1	0	Assisted	Limited_verbal	1	0	Special_ed	1	1	0	null	null	0	50.4	11.8	8.9	0	0	5.3	26,062	54.4	56.3	97.5	48.1	59.8	45	1	1	1	0	0	1	0	184.1	7	1	1	0	0	0	0	1	0.73
HCG5-0000268	Male	White_non_Hispanic	North_America	Suburban	High	Other	Commercial	Fabry	LSD	324	301,500	XLR	4.9	0.04	6.73	16.663	9.933	6	11	6	0	1	0	0	null	WES	14.34	0	4,500	1	Neurologist	6,787.22	7.69	Delayed	87.6	32.6	60.3	109.4	55.9	0	0	0	4.17	6	1	Severe	0	119.2	0	0	0	1	0	0	1	1	1	-1.03	-2.54	1	0	0	0	120.06	52.995	5.372	8.33	0.27	30.1	2.8	0.134	22.7	273.4	127.5	414.4	4,819	1	ERT	Agalsidase_alfa	null	null	null	18	4.73	148,167	Partial_coverage	0	0	8.88	0	8,967	Intermediate	0.849	0.798	0	0	Partial	0	null	0	0	Stable	12	28	2	1	0	Assisted	Limited_verbal	1	0	Home_school_medical	1	4	0	null	null	0	66	5.7	18.7	1	10,614	5.4	11,066	61	94.3	71.5	62.6	27.1	32.2	1	0	1	1	0	1	0	129.3	6	1	0	0	0	0	0	6	0
HCG5-0000269	Female	White_non_Hispanic	Asia_Pacific	Rural	High	English	Commercial	Gaucher_type1	LSD	355	230,800	AR	6.99	0.05	4.51	12.077	7.567	2	17	16	2	0	0	0	null	Metabolic	10.57	0	900	1	Metabolic_specialist	26,264.02	5.99	Regression	15.3	65.8	46.5	69.3	14.4	0	0	0	5.07	8	1	Mild	0	108.7	0	0	1	1	1	0	1	1	0	-3.11	-2.29	0	0	1	0	158.25	12.221	8.217	2.83	2.41	20	2.29	0.198	135.1	367	57.2	722.2	317.1	1	ASO	null	null	Custom_ASO	null	12.25	15.06	556,641	Partial_coverage	0	0	5.3	0	2,487	Intermediate	0.465	0.789	0	0	Responder	0	null	0	0	Stable	3	10	3	0	0	Wheelchair	AAC_device	0	0	Mainstream_with_support	1	4	0	null	null	0	43.6	5.6	7.1	1	35,702	5.5	1,589	86.8	42.2	44.8	34.2	17.7	46.4	1	0	0	1	1	0	0	39.4	15	1	0	1	1	0	0	6	5.13
HCG5-0000270	Male	Other_Multi	Europe	Suburban	Low	Other	Uninsured	Gaucher_type1	LSD	355	230,800	AR	4.85	0.05	0.01	3.316	3.306	0	15	3	3	1	0	0	null	null	15.06	0	0	1	Metabolic_specialist	142,391.48	7.45	Delayed	73.7	60.9	56.4	78.3	121.4	0	0	0	5.7	8	0	null	0	50.2	0	0	1	1	1	0	1	1	1	-1.5	2.3	0	0	1	0	236.39	22.234	36.4	2.01	3.59	20	2.81	0.134	115.1	720.9	174.8	82.1	1,862.4	1	ERT	Taliglucerase	null	null	null	4.27	2.22	172,879	Fully_covered	0	0	9.8	1	1,358	Cost_saving	0.389	0.671	0	1	Responder	0	null	0	0	Stable	1	17	2	1	0	Assisted	Limited_verbal	0	0	Mainstream_with_support	0	4	0	null	null	0	61.2	8.9	2.8	1	300,000	5.5	9,319	50.4	42.3	67.2	63.6	48	35.6	1	0	0	1	0	1	1	548.2	32	1	0	0	0	0	0	1	0
HCG5-0000271	Female	White_non_Hispanic	Asia_Pacific	Suburban	Middle	English	Uninsured	MPS_I_Hurler	LSD	579	607,014	AR	8.4	0.8	0.008	0.008	0	0	4	14	5	0	1	1	3.1	WES	1.02	0	4,500	0	NBS_followup	26,219.74	7.83	Profound_delay	83.6	11.7	32.8	66.2	46.2	1	0	0	1.22	8	0	null	1	45.4	0	1	0	0	0	0	0	0	1	-1.67	-1.09	0	0	1	1	259.99	5.963	39.075	5.88	0.4	29.6	2.92	0.157	1,265.9	125.8	25	71.1	1,571.7	1	ERT	Laronidase	null	null	null	2.41	33.18	261,644	Prior_auth_required	0	0	20.07	1	11,072	Low_value	0.413	0.737	0	0	Non_responder	0	null	0	0	Moderate	3	18	0	1	0	Bedbound	Nonverbal	1	1	Home_school_medical	1	2	1	11.94	Cardiac	0	54.2	14.7	10.1	0	0	8.8	15,676	36.8	33.8	24.2	3.4	29.4	41	1	1	0	1	0	1	1	20.5	24	1	0	0	0	0	0	0	0
HCG5-0000272	Female	White_non_Hispanic	Europe	Suburban	High	Spanish	Commercial	Gaucher_type1	LSD	355	230,800	AR	5.98	0.05	7.114	18	13.712	2	4	15	5	0	0	0	null	Single_gene	7.69	0	800	1	Geneticist	90,408.5	7.7	Delayed	57.8	44.4	20.1	44.3	97.2	0	0	0	2.44	1	0	null	0	58.9	0	0	1	0	0	0	0	0	1	-1.66	-2.27	1	1	1	0	807.7	13.865	14.145	11.59	6.09	259.1	4.86	0.093	248.3	609.8	28.5	724.9	328	1	Chaperone	null	null	null	null	18	6.41	1,816,072	Fully_covered	0	0	25.27	1	4,576	Low_value	0.665	0.231	0	0	Partial	0	null	0	0	Stable	3	19	4	1	0	Assisted	Limited_verbal	0	0	Home_school_medical	1	4	0	null	null	0	41	15	8.9	1	70,806	3.5	20,134	71.4	70.9	56.2	48.2	21.7	61.4	0	0	0	1	1	1	0	2	41	0	1	1	0	0	0	3	3.38
HCG5-0000273	Female	Black_non_Hispanic	Latin_America	Suburban	Low	Spanish	Commercial	SMA_type2	NM	83,418	253,550	AR	6.79	0.25	0.009	0.009	0	0	2	8	8	1	1	1	3.3	Single_gene	2.64	0	800	0	NBS_followup	48,398.66	6.8	Regression	55.8	57.2	26.9	24.1	49	0	0	0	4.38	1	0	null	1	54.1	0	1	0	0	1	0	0	0	0	-0.86	-0.48	0	1	0	0	320.93	22.79	21.87	5.66	3.59	20	2.2	0.169	590.8	663.3	38	26.1	5,373.5	1	Chaperone	null	null	null	null	0.46	18.08	414,944	Partial_coverage	0	0	20.23	1	4,000	High_value	0.662	0.497	0	0	Partial	0	null	0	0	Moderate	2	8	1	1	0	Wheelchair	AAC_device	0	0	Mainstream	1	1	1	7.44	Other	1	58.5	9.9	16.7	1	43,271	5.6	11,351	43.5	44.2	26.6	39.7	29.3	31.4	1	0	1	1	0	0	0	3.1	13	0	1	0	0	0	1	1	4.75
HCG5-0000274	Male	White_non_Hispanic	Europe	Rural	Middle	Spanish	Commercial	MLD	LD	512	250,100	AR	9.15	0.7	0.017	0.017	0	0	3	17	2	0	1	1	6.2	WES	1.88	0	4,500	1	NBS_followup	26,729.37	3.46	Profound_delay	48.2	45.2	32.5	31.5	84.3	1	0	1	0.93	8	0	null	0	107.8	0	1	1	0	1	0	1	1	0	-3.02	1.62	0	0	0	0	83.94	29.173	10.09	2.09	3.57	38.2	2.6	0.114	314.7	310.9	19.1	290.3	2,095.7	1	Small_molecule	null	null	null	Supportive_metabolic	0.34	12.52	711,786	Fully_covered	0	0	2.74	0	1,006	High_value	0.377	0.398	0	0	Partial	1	MUD	1	1	Stable	0	29	7	0	0	Bedbound	Nonverbal	1	0	Not_enrolled	1	1	1	8.11	Metabolic_crisis	1	62.8	5.9	12.1	1	25,648	4	7,909	29.7	44.3	62.8	35.2	30.7	57.6	0	0	1	0	0	1	1	89.1	17	1	0	0	0	0	0	11	0
HCG5-0000275	Male	White_non_Hispanic	Europe	Urban	Middle	Mandarin	Medicaid_CHIP	OTC	UCD	664	311,250	XLR	6.47	0.52	1.242	3.192	1.95	0	14	9	0	0	0	0	null	Metabolic	44.52	0	900	1	Metabolic_specialist	23,918.78	6.25	Regression	67.1	74	10	82.2	37.2	1	0	0	2.44	4	0	null	0	109.5	0	0	0	0	1	0	0	0	0	-0.99	-1.62	1	0	0	0	381.31	45.173	5.554	1.42	6.35	20	1.74	0.163	1,607.5	352.2	85.5	1,180.5	715.3	1	Supportive_only	null	null	null	null	null	39.63	0	Fully_covered	0	0	4.37	0	15,302	Intermediate	0.637	null	0	0	Not_applicable	0	null	0	0	Moderate	3	16	4	0	0	Wheelchair	AAC_device	0	0	Special_ed	1	3	0	null	null	0	43.1	8.9	15.2	0	0	6	3,233	69.4	33	55.9	0	62.5	41.5	0	0	0	1	1	0	1	4.5	4	1	1	0	0	0	0	0	3.11
HCG5-0000276	Female	White_non_Hispanic	Asia_Pacific	Suburban	Middle	English	Commercial	PA	OA	35	606,054	AR	5.97	0.5	0.011	0.011	0	0	2	17	0	0	1	1	4.1	Panel	1.81	1	1,500	0	NBS_followup	3,994.26	7.16	Delayed	53.8	78.3	16	48.6	69.2	0	0	0	3.22	1	0	null	0	93.9	0	0	0	0	1	0	0	1	0	-1.78	-0.47	1	1	1	0	31.57	92.262	3.156	3.31	2.29	20	2.38	0.107	83.9	390.8	42.4	535.8	2,511.4	0	Supportive_only	null	null	null	null	null	0.96	0	Fully_covered	0	0	16.54	0	1,147	Intermediate	0.449	null	0	0	Not_applicable	0	null	0	0	Slow_progression	4	22	3	1	1	Assisted	Limited_verbal	0	1	Mainstream_with_support	1	1	1	14.74	Respiratory_failure	1	36.7	12.1	0	0	0	4.1	5,090	79.4	42.5	75.6	43	28.5	54.1	1	0	1	1	1	0	1	27.2	16	0	0	0	0	0	0	0	0.91
HCG5-0000277	Male	White_non_Hispanic	Europe	Urban	Middle	English	Medicaid	MERRF	MITO	551	545,000	MT	6.65	0.22	9.537	12.891	3.354	2	8	16	2	0	0	0	null	Single_gene	9.05	1	800	1	NBS_followup	20,187.11	6.88	Regression	38.6	29.4	46.5	65.6	37.4	0	0	1	1.68	8	0	null	0	78.6	0	0	0	0	0	0	1	1	0	-2.75	-3.37	0	1	0	0	123.15	14.999	16.291	5.77	3.45	134.5	1.91	0.164	220.2	526.8	20	532	4,464.2	0	Supportive_only	null	null	null	null	null	39.9	0	Fully_covered	0	0	11.52	0	717	Intermediate	0.288	null	0	0	Not_applicable	0	null	0	0	Rapid	2	30	4	0	1	Wheelchair	AAC_device	0	0	Mainstream_with_support	1	4	0	null	null	0	24.7	3.6	9	1	38,143	5.7	16,614	44.5	65.7	72.8	60.5	50	35.5	0	0	1	1	0	0	0	187.2	4	1	0	0	0	0	0	2	1
HCG5-0000278	Female	Hispanic	North_America	Rural	Low	English	Commercial	EB_dystrophic	DERM	305	131,750	AD	6.72	0.18	0.14	2.46	2.32	6	13	9	2	1	0	0	null	Panel	20.43	0	1,500	1	Geneticist	33,156.59	3.51	Regression	68.1	65.5	50.3	67.2	118.2	0	0	1	3.25	0	0	null	1	52.9	1	0	0	0	0	0	0	0	0	-3.39	-1.15	1	0	0	0	135.6	62.196	27.394	3.08	7.23	20	1.09	0.237	37.2	253.4	25.1	231.7	308.3	0	Supportive_only	null	null	null	null	null	38.94	0	Denied	1	0	5.28	0	1,147	Cost_saving	0.392	null	0	0	Not_applicable	0	null	0	0	Slow_progression	0	14	0	0	0	Wheelchair	AAC_device	0	0	Special_ed	1	6	0	null	null	0	53.2	14.1	18.1	1	47,574	4.9	2,630	52.6	17	48	37.3	7.6	46.8	0	0	1	1	0	0	0	3.4	13	1	0	1	1	0	0	2	4.65
HCG5-0000279	Female	Black_non_Hispanic	Europe	Suburban	Low	English	Uninsured	HLH	IMM	540	267,700	AR	8.03	0.8	0.506	1.668	1.162	4	10	10	0	1	0	0	null	Panel	1.52	0	1,500	1	Geneticist	33,140.01	6.21	Profound_delay	13.5	64.1	37.2	52.5	47.9	0	0	0	2.33	8	0	null	0	103	0	0	1	0	0	0	1	1	0	0.47	1.2	0	0	0	0	350.13	28.235	7.694	10.04	3.49	25.3	3.76	0.13	647.9	362.4	24.3	155.9	100	0	Supportive_only	null	null	null	null	null	13.59	0	Prior_auth_required	0	0	2.93	0	673	High_value	0.727	null	0	0	Not_applicable	0	null	0	0	Rapid	5	29	1	1	0	Bedbound	Nonverbal	1	1	Mainstream	1	5	0	null	null	1	40.4	23.1	5.6	0	0	7.1	2,533	65.9	6.7	75.2	61.5	40.1	37.6	0	0	1	1	0	0	0	41.9	18	0	0	0	0	0	1	4	0.73
HCG5-0000280	Male	White_non_Hispanic	North_America	Urban	Low	Spanish	Medicaid	Gaucher_type1	LSD	355	230,800	AR	5.15	0.05	1.317	5.761	4.443	2	8	4	1	1	0	0	null	null	90.35	0	0	1	Other	247,526.49	5.56	Delayed	81.5	72.3	14	42.3	88.4	1	1	0	1.06	8	0	null	1	106.6	0	0	0	0	1	0	0	1	1	-1.88	-1.65	0	0	1	0	1,065.08	6.844	35.473	6.83	0.63	44.6	5.44	0.114	931.5	347.3	85.3	2,618.2	1,733.7	1	ERT	Taliglucerase	null	null	null	6.46	17.7	168,728	Prior_auth_required	0	0	0.2	1	444	Intermediate	0.55	0.516	1	1	Non_responder	0	null	0	0	Slow_progression	3	20	1	0	0	Assisted	Limited_verbal	0	0	Special_ed	1	1	0	null	null	0	53.4	7.7	8.9	0	0	4	12,522	43.5	40.8	39.2	76.6	68.3	53.8	1	0	1	0	0	1	0	50.3	9	0	0	0	1	1	0	4	3.74
HCG5-0000281	Female	White_non_Hispanic	Asia_Pacific	Urban	Low	English	Commercial	MPS_I_Hurler	LSD	579	607,014	AR	8.75	0.8	0.016	0.016	0	0	4	14	1	1	1	1	5.7	WES	1.45	1	4,500	1	NBS_followup	34,643.39	8.44	Profound_delay	36.1	55.3	71.3	49.6	59.2	0	1	0	2.73	1	0	null	1	28.9	1	0	0	1	0	0	0	0	1	-2.23	-2.44	0	0	0	1	225.36	19.388	8.615	5.42	3.48	97.7	2.18	0.226	697.4	512.6	61.6	950.5	838.6	1	ERT	Laronidase	null	null	null	0.27	19.22	1,134,658	Partial_coverage	0	0	1.59	0	4,098	Intermediate	0.329	0.792	0	1	Responder	1	MUD	0	1	Stable	2	17	0	0	1	Bedbound	Nonverbal	1	0	Home_school_medical	1	2	0	null	null	0	53.1	26.3	15.4	1	240,152	4.2	8,933	65	32	100	56.5	32.6	22.7	1	1	1	0	0	0	0	10	10	1	0	0	0	1	0	1	2.44
HCG5-0000282	Male	White_non_Hispanic	North_America	Urban	Middle	English	Uninsured	MPS_IV_Morquio	LSD	582	253,000	AR	5.65	0.3	3.003	15.198	12.194	4	5	15	1	1	0	0	null	Single_gene	97.95	0	800	0	Geneticist	47,435.72	6.94	Delayed	63.3	28.3	30.3	55.3	66.7	0	0	0	4.42	0	0	null	1	90	0	0	0	0	1	0	0	1	1	-3.17	-1.64	0	0	1	1	126.3	24.638	13.136	6.73	3.52	20	2.72	0.238	210.7	1,390.9	40.7	620.7	6,894.6	1	Small_molecule	null	null	null	Supportive_metabolic	15.31	3.7	684,916	Partial_coverage	0	0	5.08	1	353	High_value	0.589	0.847	0	0	Partial	0	null	0	0	Rapid	7	27	0	1	1	Assisted	Limited_verbal	0	0	Special_ed	0	5	1	18	Neurodegeneration	1	51.4	8.5	7.9	1	9,373	4.4	26,447	81.9	43.9	35.2	65.1	62.6	47.9	1	0	1	0	0	1	0	72.1	17	1	0	0	0	0	0	1	0
HCG5-0000283	Female	Black_non_Hispanic	North_America	Suburban	Middle	English	Medicaid	MPS_VI_Maroteaux	LSD	583	253,200	AR	6.38	0.32	2.622	8.572	5.95	3	17	14	2	1	0	0	null	Panel	4.62	0	1,500	0	Metabolic_specialist	76,762.14	7.65	Regression	49.1	41.6	38.2	90.9	74.4	0	0	0	1.22	0	0	null	0	93.4	0	0	0	0	0	0	1	1	1	-0.49	-1.38	0	0	1	1	90.17	10.454	9.985	1.48	7.47	213.8	3.73	0.196	41	252.9	34.6	252.3	1,248.4	1	ERT	Galsulfase	null	null	null	9.01	10.59	29,099	Prior_auth_required	0	0	5.15	0	3,116	High_value	0.549	0.613	0	0	Responder	0	null	0	0	Stable	3	26	2	0	0	Wheelchair	AAC_device	0	0	Home_school_medical	1	4	0	null	null	0	44.8	11.6	14.5	1	24,334	6.2	15,193	31.8	42.2	73.4	61.2	6.9	28.9	1	1	0	1	0	0	0	44.1	20	0	0	0	0	1	0	0	2.51
HCG5-0000284	Female	Asian	North_America	Urban	Low	English	Commercial	SMA_type2	NM	83,418	253,550	AR	7.26	0.25	0.029	0.029	0	0	3	13	2	1	1	1	10.7	Single_gene	0.36	1	800	1	NBS_followup	43,758.94	6.22	Regression	78.6	80.9	22.7	74.4	87.8	0	0	0	1.62	2	0	null	1	73	0	0	1	1	0	0	0	0	0	-0.59	0.82	0	0	0	0	417.82	8.701	37.07	3.01	2.44	20	2.04	0.137	220.6	379.7	37.8	128.7	2,463.7	1	Gene_therapy	null	Onasemnogene_abeparvovec	null	null	0.55	26.55	2,413,530	Partial_coverage	0	0	9.68	0	290	Low_value	0.364	0.662	0	0	Partial	0	null	0	0	Slow_progression	3	22	0	0	0	Wheelchair	AAC_device	1	0	Special_ed	0	5	0	null	null	0	30	16.1	7.8	1	105,768	6	3,520	27.7	44.6	81.1	64.8	22.3	40.2	1	0	1	1	0	0	1	107.3	12	1	0	0	0	0	0	5	1.07
HCG5-0000285	Male	Asian	Asia_Pacific	Urban	Middle	Spanish	Uninsured	CPS1	UCD	147	237,300	AR	7.27	0.62	0.01	1.877	1.867	4	19	12	5	1	0	0	null	WES	15.89	0	4,500	0	Neurologist	24,898.33	7.83	Regression	57.2	49.6	76.4	45.4	72.5	0	0	0	2.56	0	0	null	0	92.1	0	0	1	1	0	0	0	0	0	-0.82	0.21	1	0	0	0	149.18	8.442	18.98	1.95	1.38	72.1	2.49	0.128	108.5	249.5	155.5	802.4	1,499.7	1	HSCT	null	null	null	null	3.21	1.4	733,253	Denied	1	1	11.49	0	132	Cost_saving	0.286	0.794	0	0	Partial	0	null	0	0	Slow_progression	5	17	3	0	0	Wheelchair	AAC_device	1	0	Special_ed	1	6	1	14.01	Cardiac	1	54.4	12.9	10.6	0	0	5.4	28,763	22.8	36	60.9	40.4	59.2	45.3	1	0	1	1	0	0	1	51.6	14	0	0	0	0	0	0	6	0
HCG5-0000286	Female	White_non_Hispanic	North_America	Rural	Middle	Spanish	Uninsured	Gaucher_type1	LSD	355	230,800	AR	4.28	0.05	7.333	13.339	6.007	3	9	14	2	1	0	0	null	WES	15.84	0	4,500	1	Geneticist	25,007.51	7.28	Delayed	66.4	115.7	78.9	105.8	78.8	0	0	0	2.74	1	0	null	0	118.9	1	0	0	0	1	0	1	0	1	-1.87	0.52	0	0	0	0	109.6	13.61	11.559	6.1	1.38	28.1	1.95	0.145	740.4	285.9	37.9	174.6	385.3	1	ERT	Imiglucerase	null	null	null	15.05	16.75	1,275,776	Fully_covered	0	0	36	1	6,363	High_value	0.22	0.384	0	0	Responder	0	null	0	0	Slow_progression	4	11	5	0	0	Assisted	Limited_verbal	0	0	Mainstream_with_support	1	5	0	null	null	0	57.2	2.1	13.4	1	45,099	6.5	8,306	50	80.5	43.8	43.3	68.2	59.7	0	0	1	1	0	0	0	31.9	26	1	1	0	0	0	0	2	0.19
HCG5-0000287	Male	White_non_Hispanic	Asia_Pacific	Suburban	Middle	English	Medicaid	HCU_homocystinuria	OA	394	236,200	AR	6.14	0.08	0.006	0.006	0	0	3	8	0	0	1	1	2	Single_gene	1.55	0	800	1	NBS_followup	19,622.08	6.99	Regression	53.8	37.6	47.1	66.6	75.8	1	0	0	2.29	3	0	null	0	95.3	0	0	0	0	0	0	0	0	0	-0.9	-0.35	1	1	0	0	469.32	10.194	13.052	1.97	12.16	103.3	1.6	0.161	146.6	213.2	81.5	266.8	1,864.1	0	Supportive_only	null	null	null	null	null	10.98	0	Partial_coverage	0	0	3.34	0	173	Intermediate	0.124	null	0	0	Not_applicable	0	null	0	0	Stable	3	24	2	1	0	Wheelchair	AAC_device	0	0	Special_ed	1	6	0	null	null	0	79.5	14.3	5.1	1	18,182	3.1	12,407	32	64.1	45	39.7	90.8	22.7	1	0	1	0	1	0	1	81.3	4	1	0	0	0	0	0	6	0.1
HCG5-0000288	Male	White_non_Hispanic	Asia_Pacific	Urban	High	English	Medicaid	Barth_syndrome	MITO	111	302,060	XLR	6.97	0.35	0.97	8.234	7.264	7	4	27	0	0	0	0	null	Panel	13.27	0	1,500	1	Geneticist	40,126.41	8.51	Regression	52	86.5	39.8	22.9	101.7	0	0	0	4.39	5	1	Moderate	0	73.7	0	0	1	0	1	0	0	0	0	-2.79	-1.39	0	0	0	0	583.63	67.179	4.179	4.79	4.31	625.5	3.04	0.083	142.9	169.8	35.5	481.7	480	1	Small_molecule	null	null	null	Elamipretide	8.51	19.89	70,021	Partial_coverage	0	0	1.15	1	4,954	Intermediate	0.302	0.661	0	0	Responder	0	null	0	0	Stable	3	16	0	0	0	Wheelchair	AAC_device	0	0	Not_enrolled	1	2	0	null	null	0	39.3	13.6	6.7	1	12,609	5.5	4,312	72.1	42.8	38.6	67.9	63.1	20.4	0	0	0	1	0	0	1	220.7	13	1	0	0	0	0	0	1	2.44
HCG5-0000289	Male	Black_non_Hispanic	North_America	Urban	Middle	English	Commercial	Fabry	LSD	324	301,500	XLR	4.43	0.04	0.582	6.138	5.557	1	6	12	4	0	0	0	null	MLPA	5.88	0	1,000	0	Other	23,079.76	8.25	Delayed	114.4	60.9	72.8	69.7	65.2	0	0	0	2.48	6	1	Moderate	1	64.9	1	0	0	0	0	1	0	0	1	-1.54	-1.64	0	0	0	0	69.45	2.445	1.632	3.93	11.62	24.8	3.03	0.112	3,323.5	659.5	145.1	308.1	457.1	1	Gene_therapy	null	Clinical_trial	null	null	6.54	2.46	84,419	Fully_covered	0	0	2.9	0	3,419	Intermediate	0.388	0.688	0	0	Responder	0	null	0	0	Moderate	0	11	5	0	0	Assisted	Limited_verbal	1	0	Mainstream	1	4	0	null	null	0	30.9	10.8	14.7	1	25,971	5.8	10,248	41.6	71	63	43.2	79.4	66.3	1	1	0	0	0	0	0	249.2	16	1	0	0	0	0	0	5	0
HCG5-0000290	Male	White_non_Hispanic	Asia_Pacific	Rural	High	English	Medicaid	CGD	IMM	379	306,400	XLR	5.42	0.25	0.01	11.818	11.808	1	7	19	0	0	0	0	null	WGS	2.5	0	8,500	1	Geneticist	47,213.86	8.18	Delayed	41.1	82.8	35.9	95.9	27.8	0	1	1	6.65	2	0	null	0	112.8	0	0	1	0	0	0	0	0	0	-1.87	0.29	0	0	0	0	40.59	24.536	7.551	7.24	13.23	35.8	3.87	0.273	638.5	436.2	19	1,346.1	603.3	1	HSCT	null	null	null	null	16.6	4.4	2,368,987	Fully_covered	0	0	30.24	1	3,313	High_value	0.647	0.614	0	0	Responder	0	null	0	0	Stable	8	49	1	0	0	Assisted	Limited_verbal	1	0	Mainstream	1	2	0	null	null	0	30	13.1	6.4	1	71,858	6	3,651	49.1	0	76.2	52	30.4	43.6	0	0	1	1	0	1	0	105.5	18	1	0	0	0	0	1	6	0.73
HCG5-0000291	Male	Black_non_Hispanic	North_America	Suburban	Low	Spanish	Medicaid	Gaucher_type1	LSD	355	230,800	AR	3.78	0.05	4.455	9.375	4.921	1	8	14	2	1	0	0	null	WES	14.63	1	4,500	0	Geneticist	10,848.93	6.61	Delayed	94.9	70.9	81.5	59.8	53.9	1	1	0	5.74	1	0	null	0	88	0	0	1	0	1	0	1	0	1	-1.48	2.14	0	1	0	0	164.39	35.712	10.231	1.72	1.7	20	2.22	0.18	889.9	382.4	78.6	57.3	552.6	1	ERT	Velaglucerase	null	null	null	11.04	2.15	60,475	Denied	0	0	6.76	1	1,121	Intermediate	0.568	0.769	0	0	Responder	0	null	0	0	Stable	6	26	0	0	0	Ambulatory	Verbal	0	0	Special_ed	1	3	0	null	null	0	44.3	14.8	10.6	1	24,216	5.9	735	67	61.5	73.6	52.9	55.4	19.9	0	0	1	0	0	0	0	134.8	26	1	0	0	0	0	0	2	0.56
HCG5-0000292	Female	Black_non_Hispanic	North_America	Suburban	Middle	English	Medicaid	CDKL5_encephalopathy	SYN	3,095	300,672	XLD	8.34	0.22	0.057	7.825	7.768	1	13	31	1	0	0	0	null	WES	3.06	0	4,500	1	Neurologist	30,704.47	8.68	Profound_delay	56	50.5	30.1	44.5	29.1	1	0	1	2.95	4	0	null	0	42.4	1	0	0	0	0	0	0	1	0	-3.98	-1.91	0	1	1	0	57.96	9.332	19.651	6.43	1.59	20	1.08	0.27	132.4	235.8	26.3	263.5	1,464.9	0	Supportive_only	null	null	null	null	null	2.12	0	Partial_coverage	0	0	16.63	0	674	High_value	0.455	null	0	0	Not_applicable	0	null	0	0	Rapid	3	26	0	0	0	Bedbound	Nonverbal	1	0	Not_enrolled	1	3	0	null	null	0	59.9	8.2	16	1	36,522	6.1	37,915	34.3	58.2	56.4	54.9	13.8	44.7	0	0	1	0	0	1	1	26.5	18	1	0	0	1	0	0	0	2.33
HCG5-0000293	Male	White_non_Hispanic	Asia_Pacific	Urban	High	English	Medicaid	Fabry	LSD	324	301,500	XLR	7.43	0.04	0.01	4.425	4.415	3	15	17	5	1	0	0	null	null	2.78	0	0	1	Geneticist	108,755.83	9.41	Regression	79.4	65.2	58.9	25.9	37.5	0	0	0	2.47	0	1	Mild	0	85.5	0	0	0	1	1	0	1	0	1	0.44	-2.03	0	1	1	0	50.55	18.016	10.519	1.9	2.96	20	4.33	0.248	65.3	351.6	210.5	2,570.5	1,221.7	1	ERT	Agalsidase_beta	null	null	null	10.29	24.88	225,007	Fully_covered	0	0	4.03	1	1,076	High_value	0.083	0.785	0	0	Responder	0	null	0	0	Stable	2	25	0	0	0	Wheelchair	AAC_device	1	0	Special_ed	1	5	0	null	null	0	60.4	16.4	11.3	1	26,271	6.3	2,593	51.6	32.5	30.6	65.9	70.3	43.1	0	0	0	1	0	0	0	40.9	8	1	0	0	0	0	0	7	0.58
HCG5-0000294	Male	White_non_Hispanic	Latin_America	Urban	High	English	Commercial	HLH	IMM	540	267,700	AR	9.68	0.8	1.232	1.353	0.121	1	6	8	0	1	0	0	null	WES	7.53	0	4,500	1	Neurologist	21,978.91	4.65	Profound_delay	48.4	28.3	42.4	14.3	25.2	0	0	0	3.3	1	0	null	1	57.2	0	0	1	1	0	0	0	0	0	0.14	-2.22	0	1	0	0	64.03	16.315	7.986	2.07	5.77	35.7	1.43	0.146	880.2	204.8	72.8	656.4	2,402.2	0	Supportive_only	null	null	null	null	null	5.22	0	Denied	0	0	4.26	0	3,037	High_value	0.473	null	0	0	Not_applicable	1	Haplo	0	1	Slow_progression	13	26	5	0	0	Bedbound	Nonverbal	1	0	Mainstream_with_support	1	4	1	8.97	Other	1	71.7	10.2	12.8	0	0	8.1	3,528	57.4	47.7	85	60.9	34.4	43.3	0	0	1	1	0	0	1	91.4	5	1	0	0	0	0	0	6	2.19
HCG5-0000295	Female	White_non_Hispanic	North_America	Urban	Middle	Other	Commercial	Rett	SYN	778	312,750	XLD	5.9	0.12	2.472	8.55	6.078	2	13	17	2	0	0	0	null	Metabolic	16.96	0	900	0	Geneticist	141,308.6	3.08	Delayed	61.7	78.6	46.2	45.8	65.3	1	0	1	3.34	2	1	Mild	0	87	0	0	0	1	0	1	0	0	0	-3.18	0.93	0	0	0	0	516.22	20.705	0.858	4	0.94	20	1.42	0.147	1,466.3	360.1	13.6	197	374.6	0	Small_molecule	null	null	null	Supportive_metabolic	10.6	4.81	651,123	Denied	1	1	1.43	1	1,372	Low_value	0.124	0.48	0	0	Responder	0	null	0	0	Stable	5	43	0	1	0	Assisted	Limited_verbal	0	0	Not_enrolled	1	6	0	null	null	0	52.1	22	18.2	0	0	6.6	3,309	100	35.7	56.9	21	60.9	53.1	0	1	0	1	1	0	1	71.6	13	1	1	0	0	0	0	10	0.79
HCG5-0000296	Male	White_non_Hispanic	Europe	Suburban	Middle	Spanish	Commercial	22q11_2_DiGeorge	SYN	567	188,400	AD	5.85	0.08	0.617	4.506	3.889	4	13	11	2	1	0	0	null	Single_gene	80.46	0	800	0	Metabolic_specialist	31,172.9	8.88	Delayed	80.3	58.7	16	38.7	71.5	1	0	0	2.24	7	1	Mild	0	77.1	0	0	0	0	0	0	0	0	0	-1.11	-0.47	0	0	0	0	347.37	40.312	19.579	11.65	5	20	1.62	0.243	52.3	431.3	23.3	589.2	1,405.7	0	Supportive_only	null	null	null	null	null	33.1	0	Partial_coverage	0	0	4.96	0	572	Intermediate	0.577	null	0	0	Not_applicable	0	null	0	0	Rapid	5	10	2	1	0	Assisted	Limited_verbal	0	0	Mainstream_with_support	1	4	0	null	null	0	29.9	19	21	1	35,864	4	38,128	62.2	55.2	53.1	63.8	0	22.3	0	0	0	1	0	1	1	106.9	3	1	1	0	0	0	0	3	2.76
HCG5-0000297	Male	White_non_Hispanic	North_America	Urban	Middle	English	Commercial	Diastrophic	SKEL	628	222,600	AR	4.59	0.1	0.045	0.278	0.233	1	9	13	3	0	0	0	null	Panel	29.35	1	1,500	1	Geneticist	25,569.17	6.58	Delayed	74.3	74.9	62.7	58.4	78.6	0	0	1	2.86	2	0	null	0	117.1	0	0	0	0	0	0	0	1	0	-3.58	0.49	0	0	0	0	2,116.41	37.19	14.73	2.29	4.78	20	0.78	0.224	131.5	278.3	72.2	232.2	1,117.3	0	HSCT	null	null	null	null	2.87	6.84	570,950	Fully_covered	0	0	6.75	0	7,651	Intermediate	0.582	0.653	0	0	Responder	0	null	0	0	Moderate	7	21	0	1	0	Assisted	Limited_verbal	0	0	Mainstream_with_support	0	1	0	null	null	1	49	6.4	10.8	1	29,682	6.8	10,061	30.1	26.2	67.2	58.7	0	49.1	0	0	1	1	0	1	0	266.7	7	0	0	1	0	0	0	3	1.98
HCG5-0000298	Female	Hispanic	Europe	Urban	Middle	English	Medicaid_CHIP	Achondroplasia	SKEL	15	100,800	AD	3.99	0.04	0.05	0.852	0.802	0	4	9	0	0	0	0	null	Single_gene	46.21	0	800	1	Metabolic_specialist	29,880.36	4.42	Delayed	87.6	25	41.6	107.1	60.8	0	0	1	6.6	1	0	null	0	35.8	0	0	0	0	0	0	0	0	0	-1.7	-1.21	0	0	1	0	95.4	12.936	25.342	1.08	1.21	254.4	1.95	0.245	81.7	250	70.8	1,227.8	2,211.4	0	Supportive_only	null	null	null	null	null	28.79	0	Fully_covered	0	0	14.6	0	339	Low_value	0.429	null	0	0	Not_applicable	0	null	0	0	Rapid	0	21	0	0	0	Ambulatory	Verbal	0	0	Mainstream_with_support	0	3	0	null	null	0	15.8	19.6	7.9	1	18,942	5.6	11,696	72.4	72.1	32.5	64.4	93.8	40.4	0	0	0	0	0	0	1	48.1	37	0	0	0	0	0	1	7	2.42
HCG5-0000299	Female	White_non_Hispanic	Europe	Suburban	Middle	English	Medicaid	Congenital_myopathy	NM	97,245	160,150	AR	5.79	0.18	1.033	4.056	3.024	1	8	16	1	1	0	0	null	Karyotype	21.19	0	1,200	1	Geneticist	20,327.28	5.22	Delayed	88.1	57.7	61.1	61.7	88.3	1	0	1	0.64	7	0	null	1	57.1	0	1	0	0	1	0	0	0	0	-4.43	0.59	1	0	0	0	685.29	5.732	12.485	2.1	1.24	365.5	3.23	0.164	436	285.4	67.2	603.9	2,320.1	0	Small_molecule	null	null	null	Supportive_metabolic	4.14	3.14	497,642	Prior_auth_required	0	0	11.08	1	220	High_value	0.567	0.841	0	0	Responder	0	null	0	0	Stable	7	3	2	1	0	Assisted	Limited_verbal	0	0	Special_ed	1	2	0	null	null	0	41.8	15.2	14.6	0	0	5.1	16,326	61	48.7	59.3	50.2	100	48.3	1	0	0	1	0	0	0	10.7	23	1	0	0	0	0	0	0	0

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