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1 | TITLE: Effectiveness of two preventive interventions for coronary heart disease in primary care.ABSTRACT: 1. To compare a patient-centred, self-directive intervention with conventional care; 2. To evaluate longitudinal within-group changes of coronary heart disease risk.Risk factor changes were evaluated in 110 men wit... |
1 | TITLE: Sulbactam/cefoperazone versus cefotaxime for the treatment of moderate-to-severe bacterial infections: results of a randomized, controlled clinical trial.ABSTRACT: We conducted a randomized, open-label, controlled, multicenter study to compare sulbactam/cefoperazone with cefotaxime in terms of efficacy and safet... |
1 | TITLE: Comparison of single-dose cefuroxime axetil with ciprofloxacin in treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing Neisseria gonorrhoeae strains.ABSTRACT: A randomized, multicenter, investigator-blind trial was conducted to compare the efficacies of cefuroxim... |
1 | TITLE: Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial.ABSTRACT: The Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial compared the efficacy and safety of intravenous hirudin with heparin as adjuncti... |
1 | TITLE: Intravenous amiodarone in treatment of recent-onset atrial fibrillation: results of a randomized, controlled study.ABSTRACT: This study was designed to determine the efficacy of intravenous amiodarone in the management of recent-onset atrial fibrillation.The optimal approach for acute atrial fibrillation has not... |
0 | TITLE: Differing metabolism and bioactivity of atrial and brain natriuretic peptides in essential hypertension.ABSTRACT: Plasma concentrations of both atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are elevated in severe hypertension, acute myocardial infarction, and heart failure. In the current ... |
0 | TITLE: Partial vs full beta-receptor agonism. A clinical study of inhaled albuterol and fenoterol.ABSTRACT: To compare the maximal extrapulmonary effects of the beta-agonists albuterol and fenoterol in eight healthy volunteers.In this double-blind study, we have examined the maximum cardiac effects (electromechanical s... |
1 | TITLE: A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Français du Myélome.ABSTRACT: The median survival of patients with myeloma after conventional chemotherapy is three years or less. Promising results have been reported with high-dose therap... |
1 | TITLE: Patient-controlled analgesia for conscious sedation during endoscopic retrograde cholangiopancreatography: a randomized controlled trial.ABSTRACT: Adequate comfort is essential to patients undergoing invasive procedures. This study was designed to evaluate whether patient-controlled analgesia could improve sedat... |
0 | TITLE: The effects of clonidine premedication on sevoflurane requirements and anesthetic induction time.ABSTRACT: We assessed the effects of oral clonidine preanesthetic medication (4.5 microg/kg) on the vital capacity rapid-inhalation anesthetic induction time (VCRII time) and minimum alveolar anesthetic concentration... |
1 | TITLE: Emergence and clinical relevance of mutations associated with zidovudine resistance in asymptomatic HIV-1 infected patients.ABSTRACT: The dynamics leading to the emergence of a zidovudine-resistant mutation at codon 215 of the reverse transcriptase coding region was investigated in a cohort of HIV-infected indiv... |
0 | TITLE: Relationships of blood pressure to fibrinolysis: influence of anthropometry, metabolic profile and behavioural variables.ABSTRACT: To investigate the relationship between blood pressure and the plasma fibrinolytic system and to verify whether this association was independent or mediated by one or more potential ... |
1 | TITLE: Butorphanol: an opioid for day-care paediatric surgery.ABSTRACT: The purpose of this study was to compare the side effects and efficacy of equianalgesic doses of morphine (M) and butorphanol (B) in children undergoing similar surgical procedures associated with moderate postoperative pain. We studied 156 healthy... |
0 | TITLE: Inner city air pollution and respiratory health and atopy in children.ABSTRACT: The impact of inner city air pollution on the development of respiratory and atopic diseases in childhood is still unclear. In a cross sectional study in Dresden, Germany, 5,421 children in two age groups (5-7 yrs and 9-11 yrs) were ... |
1 | TITLE: Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam.ABSTRACT: The calcium channel blockers mibefradil and isradipine inhibit CYP3A4 in vitro. However, their in vivo inhibitory effects on CYP3A4 are not known in detail, although mibefradil was recently ... |
1 | TITLE: Bone densitometry: a new, highly responsive region of interest in the distal forearm to monitor the effect of osteoporosis treatment.ABSTRACT: The bisphosphonates have been introduced as alternatives to hormone replacement therapy (HRT) for the treatment and prevention of postmenopausal osteoporosis. The expecte... |
1 | TITLE: Effects of digoxin and digitoxin on circadian blood pressure profile in healthy volunteers.ABSTRACT: The aim of the study was to investigate the potential effects of chronic digoxin or digitoxin treatment or circadian blood pressure profile in normotensive subjects.In two randomized double-blind, placebo-control... |
1 | TITLE: Efficacy of ondansetron and prochlorperazine for the prevention of postoperative nausea and vomiting after total hip replacement or total knee replacement procedures: a randomized, double-blind, comparative trial.ABSTRACT: Limited data are available on the efficacy of ondansetron hydrochloride compared with proc... |
1 | TITLE: Effect of diaspirin cross-linked hemoglobin on endothelin-1 and blood pressure in acute ischemic stroke in man.ABSTRACT: For almost 50 years it has been known that hemolysed blood can increase blood pressure. Although preclinical studies suggest that this pressor response is due to an interaction of hemoglobin w... |
1 | TITLE: Effects of an ionic versus a nonionic low osmolar contrast agent on the thrombotic complications of coronary angioplasty.ABSTRACT: An increasing body of evidence suggests that the potential for thrombotic complications is greater with nonionic than with ionic contrast agents. This is a particularly important con... |
1 | TITLE: Weight gain of Kenyan school children infected with hookworm, Trichuris trichiura and Ascaris lumbricoides is improved following once- or twice-yearly treatment with albendazole.ABSTRACT: We studied growth in infected children given one dose (600 mg) or two doses of albendazole per school year. Children were exa... |
1 | TITLE: Effects of enalapril on ventricular volumes and neurohumoral status after inferior wall myocardial infarction.ABSTRACT: The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system and its beneficial modification with the use of angiotensin-converting enzyme inhibin after inferio... |
1 | TITLE: Relationship between salt and blood pressure in hypertensive patients on chronic ACE-inhibition.ABSTRACT: We investigated the effect of a 4-day oral salt load (150 mmol NaCl extra per day) on blood pressure, erythrocyte sodium transport and the activity in the renin-angiotensin system in six males with primary h... |
1 | TITLE: Re-evaluation of i.m. ephedrine as prophylaxis against hypotension associated with spinal anaesthesia for Caesarean section.ABSTRACT: To assess the safety and efficacy of 37.5 mg ephedrine i.m. in preventing hypotension associated with spinal anaesthesia for Caesarean section.In a double-blind randomised control... |
0 | TITLE: Insulin therapy in burn patients does not contribute to hepatic triglyceride production.ABSTRACT: Lipid kinetics were studied in six severely burned patients who were treated with a high dose of exogenous insulin plus glucose to promote protein metabolism. The patients were 20+/-2-yr-old (SD) with 63+/-8% total ... |
0 | TITLE: An oral sodium citrate-citric acid non-particulate buffer in humans.ABSTRACT: We have investigated the effect on the pH of the gastric fluid of a single dose of sodium citrate 0.3 mol litre-1 (antacid) and a solution containing sodium citrate dehydrate (100 mg ml-1) with citric acid monohydrate (66 mg ml-1) (buf... |
1 | TITLE: A randomised, double-blind, parallel-group study to compare the efficacy and safety of ondansetron (GR38032F) plus dexamethasone with metoclopramide plus dexamethasone in the prophylaxis of nausea and emesis induced by carboplatin chemotherapy.ABSTRACT: A double-blind, parallel-group study in 189 ovarian cancer ... |
1 | TITLE: Randomized trial of two versus five years of adjuvant tamoxifen for postmenopausal early stage breast cancer. Swedish Breast Cancer Cooperative Group.ABSTRACT: Postsurgical treatment with tamoxifen has been shown to improve overall survival among patients with early stage breast cancer. However, the optimal dura... |
1 | TITLE: Hemodynamic effects of the class III antiarrhythmic drug, d-sotalol, in patients with congestive heart failure.ABSTRACT: In contrast to Vaughan Williams class I drugs, class III drugs, such as d-sotalol, may not be negative inotropic. These drugs block potassium ion channels and prolong repolarization, theoretic... |
1 | TITLE: Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast/Beclomethasone Study Group.ABSTRACT: Oral leukotriene receptor antagonists have been shown to have efficacy in chronic asthma.To compare the clinical benefit of montelukast, a once-daily oral leu... |
1 | TITLE: The contribution of the swallowed fraction of an inhaled dose of salmeterol to it systemic effects.ABSTRACT: Salmeterol is approximately eight times as potent as salbutamol for systemic effects. This may be because the drug is eight times more potent on receptors or there may be differences in systemic bioavaila... |
1 | TITLE: Corticosteroid treatment of erythema multiforme major (Stevens-Johnson syndrome) in children.ABSTRACT: The effectiveness of systemic corticosteroids in erythema multiforme major (EMM) is controversial. We therefore evaluated the efficacy of corticosteroids in the treatment of EMM in a prospective study of 16 chi... |
1 | TITLE: Triazolam is ineffective in patients taking rifampin.ABSTRACT: Triazolam is metabolized predominantly by cytochrome P450 3A4 (CYP3A4). Rifampin (rifampicin) is a potent inducer of CYP3A4 and it is known to markedly reduce plasma concentrations and effects of drugs such as midazolam. The possible interaction betw... |
1 | TITLE: Post-partum urinary retention: a comparison between two methods of epidural analgesia.ABSTRACT: To compare two methods of epidural labor analgesia regarding the incidence of post-partum urinary retention.One thousand parturients who requested epidural analgesia for the relief of labor pain received, at random, e... |
1 | TITLE: Use of tunneled femoral catheters to prevent catheter-related infection. A randomized, controlled trial.ABSTRACT: The risk for catheter-related infection seems higher with femoral catheters than with catheters inserted at other sites.To evaluate the effect of catheter tunneling on femoral catheter-related infect... |
1 | TITLE: A high dose of albuterol does not overcome bronchoprotective subsensitivity in asthmatic subjects receiving regular salmeterol or formoterol.ABSTRACT: Regular treatment with inhaled, long-acting beta2 -agonists is associated with subsensitivity for bronchoprotective effects. It is not known whether a high dose o... |
1 | TITLE: Serum S100beta release after coronary artery bypass grafting: roller versus centrifugal pump.ABSTRACT: Microemboli generated during cardiopulmonary bypass (CPB) are implicated in the cerebral injury seen after coronary artery bypass grafting. Centrifugal pumps generate fewer microemboli than roller pumps. Increa... |
1 | TITLE: A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations.ABSTRACT: Tocotrienols, lipid-soluble antioxidants with vitamin E activity, have been reported to lower LDL-cholesterol concentrations and platelet... |
0 | TITLE: Clonidine premedication modifies responses to adrenoceptor agonists and baroreflex sensitivity.ABSTRACT: To evaluate the effects of clonidine on responses to adrenoceptor agonists and baroreflex sensitivity, we examined arterial blood pressure (AP) responses to phenylephrine and heart rate (HR) responses to isop... |
1 | TITLE: Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity--a controlled crossover trial.ABSTRACT: Plant-derived estrogen analogs (phytoestrogens) may confer significant health advantages including cholesterol reduction, antioxidant activity, and possibly a reduced... |
1 | TITLE: Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland)ABSTRACT: Some epidemiological investigations suggest that higher intake or biochemical status of vitamin E and beta-carotene might be associated with reduced risk of colorectal cancer.We tes... |
1 | TITLE: Improvement in exercise capacity with nitric oxide inhalation in patients with precapillary pulmonary hypertension.ABSTRACT: Patients with precapillary pulmonary hypertension (PH) exhibit a poor exercise capacity due to an impaired vasodilatory response of their pulmonary arteries. By causing the pulmonary arter... |
1 | TITLE: Pulmonary effects of short-term exposure to low levels of toluene diisocyanate in asymptomatic subjects.ABSTRACT: Isocyanates may be involved in the development of chronic obstructive airway disease among exposed workers. A short-term exposure to toluene diisocyanate (TDI) at concentrations near the permissible ... |
1 | TITLE: Oestrogen has no short-term effect on intestinal strontium absorption in healthy postmenopausal women.ABSTRACT: Impaired intestinal calcium absorption in postmenopausal women is often indirectly linked to decreased serum 1,25(OH)2D or to intestinal resistance to its action rather than directly to low circulating... |
1 | TITLE: Comparative efficacy and safety of calcium carbasalate plus metoclopramide versus ergotamine tartrate plus caffeine in the treatment of acute migraine attacks.ABSTRACT: This randomized, double-blind, double-dummy, multicenter, parallel-group study aimed at comparing the efficacy and safety of calcium carbasalate... |
1 | TITLE: Benzalkonium chloride in a decongestant nasal spray aggravates rhinitis medicamentosa in healthy volunteers.ABSTRACT: A randomized double-blind parallel study with 20 healthy volunteers was performed to research the effect of a preservative in a decongestant nasal spray on the development of rhinitis medicamento... |
1 | TITLE: Randomized comparison of oral misoprostol and oxytocin for labor induction in term prelabor membrane rupture.ABSTRACT: To compare labor induction intervals between oral misoprostol and intravenous oxytocin in women who present at term with premature rupture of membranes.One hundred eight women were randomly assi... |
1 | TITLE: The safety and efficacy of prophylactic ondansetron in patients undergoing modified radical mastectomy.ABSTRACT: We aimed to evaluate the antiemetic efficacy, safety, and clinical utility of prophylactic ondansetron administered at the end of the surgery for the prevention of postoperative nausea and vomiting (P... |
1 | TITLE: Effect of chronic magnesium supplementation on magnesium distribution in healthy volunteers evaluated by 31P-NMRS and ion selective electrodes.ABSTRACT: The role of magnesium (Mg) intake in the prevention and treatment of diseases is greatly debated. Mg biodistribution after chronic Mg supplementation was invest... |
0 | TITLE: Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome.ABSTRACT: In 43 amenorrheic women with polycystic ovary syndrome (PCOS), 31 (74%) with fasting hyperinsulinemia (> or =20 microU/mL), our aim was to determine whether Metformin (Bristol... |
0 | TITLE: CYP2D6 status of extensive metabolizers after multiple-dose fluoxetine, fluvoxamine, paroxetine, or sertraline.ABSTRACT: The aim of this study was to evaluate the CYP2D6 inhibitory effects of four selective rerotonin re-uptake inhibitors (SSRIs). Thirty-one healthy subjects were phenotyped as extensive metaboliz... |
1 | TITLE: Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non-Small Cell Lung Cancer Study Group.ABSTRACT: To confirm the promising phase II results of docetaxel mono... |
0 | TITLE: Human vascular renin-angiotensin system and its functional changes in relation to different sodium intakes.ABSTRACT: A growing body of evidence supports the existence of a tissue-based renin-angiotensin system (RAS) in the vasculature, but the functional capacity of vascular RAS was not investigated in humans. I... |
1 | TITLE: A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group.ABSTRACT: Critically ill patients who require mechanical ventilation are at increased risk for gastrointestinal bleeding from stress ul... |
0 | TITLE: The course of labor with and without epidural analgesia.ABSTRACT: Our purpose was to measure effects of epidural analgesia on labor compared with boluses of meperidine in a cohort of women with similar clinical circumstances.One hundred ninety-nine nulliparous women who were delivered spontaneously at term and w... |
0 | TITLE: Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study.ABSTRACT: DNA damage from polycyclic aromatic hydrocarbons (PAH) and other aromatic/hydrophobic compounds has been implicated in case-control studies as a ri... |
1 | TITLE: A study of hormone replacement therapy in postmenopausal women with ischaemic heart disease: the Papworth HRT atherosclerosis study.ABSTRACT: To assess the possible benefit of hormone replacement therapy (HRT) in the secondary prevention of ischaemic heart disease.A prospective randomised trial of transdermal HR... |
0 | TITLE: Calcium and zinc absorption from lactose-containing and lactose-free infant formulas.ABSTRACT: Calcium absorption is enhanced by the presence of lactose, but the quantitative significance of this effect in infant formulas is uncertain. It is also not known whether lactose affects zinc absorption.We measured the ... |
1 | TITLE: The dose-sparing effect of clonidine added to ropivacaine for labor epidural analgesia.ABSTRACT: To determine the effects of clonidine with ropivacaine during epidural labor analgesia, we studied 66 nulliparous women in early active labor. Women were randomized to receive ropivacaine 0.1% 8 mL plus 75 microg of ... |
1 | TITLE: Increased presence of anti-HLA antibodies early after allogeneic granulocyte colony-stimulating factor-mobilized peripheral blood hematopoietic stem cell transplantation compared with bone marrow transplantation.ABSTRACT: We have recently shown that the use of allogeneic granulocyte colony-stimulating factor (G-... |
1 | TITLE: Midodrine in neurally mediated syncope: a double-blind, randomized, crossover study.ABSTRACT: Neurally mediated syncope is the most frequent cause of syncope in patients without structural heart disease. Its most common trigger is a reduction in venous return to the heart due to excessive venous pooling in the l... |
1 | TITLE: Improved suppression of recurrent atrial fibrillation with dual-site right atrial pacing and antiarrhythmic drug therapy.ABSTRACT: We compared the safety, tolerance and effectiveness of overdrive high right atrial (RA), dual-site RA and support (DDI or VDI) pacing (SP) in patients with symptomatic atrial fibrill... |
1 | TITLE: Two-site phacotrabeculectomy with intraoperative mitomycin-C: fornix- versus limbus-based conjunctival opening in fellow eyes.ABSTRACT: To prospectively compare the influence of fornix-based and limbus-based conjunctival flaps on the final outcome and complications of 2-site phacotrabeculectomy with mitomycin-C ... |
1 | TITLE: Ofloxacin for the treatment of urinary tract infections and biofilms in spinal cord injury.ABSTRACT: Forty two paraplegic and quadriplegic hospitalized spinal cord injured patients with urinary tract infections (UTI) were included in a double blind, randomized treatment study comparing 7 days ofloxacin (300 mg b... |
1 | TITLE: Early identification of neutropenic patients at risk of grampositive bacteraemia and the impact of empirical administration of vancomycin.ABSTRACT: The aim of this multicentre randomised trial was to determine whether it was possible to predict grampositive bacteraemia, and whether the empirical use of vancomyci... |
1 | TITLE: Effect of flumazenil on ventilatory drive during sedation with midazolam and alfentanil.ABSTRACT: Patients who receive a combination of a benzodiazepine and an opioid for conscious sedation are at risk for developing respiratory depression. While flumazenil effectively antagonizes the respiratory depression asso... |
1 | TITLE: Effects of the new class III antiarrhythmic drug dofetilide on the atrial and ventricular intracardiac monophasic action potential in patients with angina pectoris.ABSTRACT: The class III antiarrhythmic drug dofetilide is known to prolong action potential duration by specific blockade of the delayed rectifier po... |
1 | TITLE: Changes in the cerebral arteriovenous oxygen content difference by surgical incision are similar during sevoflurane and isoflurane anaesthesia.ABSTRACT: To investigate changes of cerebral arteriovenous oxygen content difference (AVDO2) induced by surgical incision and to determine carbon dioxide (CO2) reactivity... |
1 | TITLE: The effect of glimepiride on pancreatic beta-cell function under hyperglycaemic clamp and hyperinsulinaemic, euglycaemic clamp conditions in non-insulin-dependent diabetes mellitus.ABSTRACT: The comparative effects of glimepiride (Amaryl; HOE 490) and glibenclamide on insulin and glucose metabolism under hypergl... |
1 | TITLE: Progesterone alone versus progesterone combined with HCG as luteal support in GnRHa/HMG induced IVF cycles: a randomized clinical trial.ABSTRACT: Two different regimens of luteal support in gonadotrophin hormone-releasing hormone (GnRH) analogue/human menopausal gonadotrophin (GnRHa/HMG)-induced in-vitro fertili... |
1 | TITLE: Effectiveness of diclofenac eyedrops in reducing inflammation and the incidence of cystoid macular edema after cataract surgery.ABSTRACT: To evaluate the effectiveness of diclofenac eyedrops in reducing inflammation and the incidence of angiographic cystoid macular edema (CME) after cataract surgery and intraocu... |
1 | TITLE: Hormonal regulation of lipoprotein(a) levels: effects of estrogen replacement therapy on lipoprotein(a) and acute phase reactants in postmenopausal women.ABSTRACT: Estrogen lowers lipoprotein(a) [Lp(a)] levels, but the mechanisms involved have not been clarified. To address the relationship between estrogenic ef... |
1 | TITLE: Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation.ABSTRACT: Whether antiarrhythmic drugs improve the rate of successful resuscitation after out-of-hospital cardiac arrest has not been determined in randomized clinical trials.We conducted a randomized, double-blind,... |
1 | TITLE: Postdural puncture headache is not an age-related symptom in children: a prospective, open-randomized, parallel group study comparing a22-gauge Quincke with a 22-gauge Whitacre needle.ABSTRACT: Many reports have shown a low incidence of postdural puncture headache (PDPH) and other complaints in young children. T... |
1 | TITLE: Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. Systolic Hypertension in Europe Trial Investigators.ABSTRACT: The clinical use of ambulatory blood pressure (BP) monitoring requires further validation in prospective outcome studies.To co... |
1 | TITLE: Diabetes mellitus, glycoprotein IIb/IIIa blockade, and heparin: evidence for a complex interaction in a multicenter trial. EPILOG Investigators.ABSTRACT: After angioplasty, major complications and ischemic events occur more frequently in diabetic than nondiabetic patients. To determine whether treatment with abc... |
1 | TITLE: Piperacillin/tazobactam versus imipenem: a double-blind, randomized formulary feasibility study at a major teaching hospital.ABSTRACT: With the introduction of piperacillin/tazobactam to the North American market, hospitals have been faced with the task of making a decision regarding its formulary role. In view ... |
0 | TITLE: Effect of oral antidiabetic agents on plasma amylin level in patients with non-insulin-dependent diabetes mellitus (type 2).ABSTRACT: The purpose of the study was the comparison of the effect of the oral therapy of non-insulin-dependent diabetes mellitus (NIDDM) with either a sulphonylurea or biguanide derivativ... |
1 | TITLE: Teriparatide effects on vertebral fractures and bone mineral density in men with osteoporosis: treatment and discontinuation of therapy.ABSTRACT: Teriparatide (rhPTH[1-34]), a bone-forming agent for the treatment of osteoporosis, increases bone mineral density in men and women, and reduces the risk of fractures ... |
1 | TITLE: Levobupivacaine 0.2% or 0.125% for continuous sciatic nerve block: a prospective, randomized, double-blind comparison with 0.2% ropivacaine.ABSTRACT: In 60 patients receiving elective hallux valgus repair, we compared the efficacy of continuous popliteal sciatic nerve block produced with 0.2% ropivacaine (n = 20... |
1 | TITLE: Raloxifene to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer: a randomized controlled trial.ABSTRACT: GnRH agonists decrease bone mineral density and increase fracture risk in men with prostate cancer. Raloxifene increases bone mineral density in postmenopausal women... |
0 | TITLE: Another way to estimate outcome of advanced nasopharyngeal carcinoma--is concurrent chemoradiotherapy adequate?ABSTRACT: To evaluate a simple risk grouping system and determine whether concurrent chemoradiotherapy (CCRT) is adequate for patients with advanced nasopharyngeal carcinoma (NPC).A total of 284 patient... |
1 | TITLE: Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis.ABSTRACT: Oral daily (2.5 mg) and intermittent ibandronate (between-dose interval of >2 months), delivering a similar cumulative exposure, were evaluated in 2946 osteoporotic women with prevalent vert... |
1 | TITLE: Comprehensive lifestyle modification and blood pressure control: a review of the PREMIER trial.ABSTRACT: The PREMIER trial assessed the aggregate effect on blood pressure (BP) of nationally recommended lifestyle modifications in free-living adults with high-normal (stage 1) hypertension. Participants (N=810) wer... |
1 | TITLE: Once-daily insulin glargine compared with twice-daily NPH insulin in patients with type 1 diabetes.ABSTRACT: To present the findings in a randomized, parallel-group study, comparing once-daily insulin glargine with twice-daily NPH insulin in patients with type 1 diabetes previously treated with multiple daily in... |
0 | TITLE: Low-dose international normalized ratio self-management: a promising tool to achieve low complication rates after mechanical heart valve replacement.ABSTRACT: International normalized ratio (INR) self-management can significantly reduce INR fluctuations, bleeding, and thromboembolic events compared with INR cont... |
1 | TITLE: Rectal paracetamol has a significant morphine-sparing effect after hysterectomy.ABSTRACT: We have evaluated the morphine-sparing effect of rectal paracetamol during the first 24 h after abdominal hysterectomy in a placebo-controlled, double-blind study. We studied 72 patients receiving patient-controlled analges... |
1 | TITLE: Randomised controlled trial of thiopental for intubation in neonates.ABSTRACT: To determine the effects of premedication with thiopental on heart rate, blood pressure, and oxygen saturation during semi-elective nasotracheal intubation in neonates.A randomised, placebo controlled, non-blinded study design was use... |
1 | TITLE: The misoprostol third stage of labour study: a randomised controlled comparison between orally administered misoprostol and standard management.ABSTRACT: To compare misoprostol with standard oxytocic regimens in the prevention of postpartum haemorrhage.Randomised controlled trial.Obstetric unit in a large teachi... |
0 | TITLE: Long-term, open-label study of the safety and efficacy of atomoxetine in adults with attention-deficit/hyperactivity disorder: an interim analysis.ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is an early-onset neuropsychiatric disorder that affects 3% to 7% of school-age children and 4% of adults. I... |
1 | TITLE: Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial.ABSTRACT: This double-blind, randomized, placebo-controlled study in epileptic children, aged 3 to 12 years, evaluated the effect of add-on melatonin on the sleep behavior of these children on s... |
1 | TITLE: A randomized trial of electronic clinical reminders to improve quality of care for diabetes and coronary artery disease.ABSTRACT: The aim of this study was to evaluate the impact of an integrated patient-specific electronic clinical reminder system on diabetes and coronary artery disease (CAD) care and to assess... |
1 | TITLE: Losartan benefits over atenolol in non-smoking hypertensive patients with left ventricular hypertrophy: the LIFE study.ABSTRACT: We studied the impact of smoking in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study, which showed superiority of losartan over atenolol for reduction of c... |
1 | TITLE: Analysis of morbidity in patients with endometrial cancer: is there a commitment to offer laparoscopy?ABSTRACT: Benefits of laparoscopy over laparotomy in patients with endometrial cancer (EC) are well known. As many patients with EC carry co-morbid conditions, surgery is exposing them to increased risk of compl... |
1 | TITLE: Impact of an adherence clinic on behavioral outcomes and virologic response in treatment of HIV infection: a prospective, randomized, controlled pilot study.ABSTRACT: The aim of this randomized, controlled pilot study was to examine the impact of a pharmacist operated adherence clinic on adherence to highly acti... |
1 | TITLE: Comparative trial of short-course ofloxacin for uncomplicated typhoid fever in Vietnamese children.ABSTRACT: An open, randomised comparison of 2 or 3 days of oral ofloxacin (10 mg/kg/day) for uncomplicated typhoid fever was conducted in 235 Vietnamese children. Multi-drug-resistant Salmonella typhi was isolated ... |
1 | TITLE: Twenty-four-hour diurnal curve comparison of commercially available latanoprost 0.005% versus the timolol and dorzolamide fixed combination.ABSTRACT: To evaluate the efficacy and safety of commercially available latanoprost 0.005% given every evening versus timolol 0.5% and dorzolamide 2% fixed combination (TDFC... |
1 | TITLE: Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: a double-blind trial using proton and lithium magnetic resonance spectroscopy.ABSTRACT: Oral choline administration has been reported to increase brain phosphatidylcholine levels. As phospholipid synthesis... |
0 | TITLE: Effects of iron(II) salts and iron(III) complexes on trace element status in children with iron-deficiency anemia.ABSTRACT: Iron-deficiency anemia (IDA) is the most common nutritional deficiency in childhood throughout the world. Although it has been shown that IRA is associated with elevated plasma copper and d... |
1 | TITLE: The effects of sevelamer and calcium acetate on proxies of atherosclerotic and arteriosclerotic vascular disease in hemodialysis patients.ABSTRACT: We recently determined that in hemodialysis patients, the use of calcium salts to correct hyperphosphatemia led to progressive coronary artery and aortic calcificati... |
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