headings sequence | keywords sequence | title stringlengths 30 189 | id stringlengths 14 14 | sections sequence | abstract sequence | summary sequence | year stringclasses 11
values |
|---|---|---|---|---|---|---|---|
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"epidemiology and global health"
] | National and regional seasonal dynamics of all-cause and cause-specific mortality in the USA from 1980 to 2016 | elife-35500-v1 | [
[
"It is well-established that death rates vary throughout the year , and in temperate climates there tend to be more deaths in winter than in summer ( Campbell , 2017; Fowler et al . , 2015; Healy , 2003; McKee , 1989 ) .",
"It has therefore been hypothesized that a warmer world may lower winter mortality ... | [
"In temperate climates , winter deaths exceed summer ones .",
"However , there is limited information on the timing and the relative magnitudes of maximum and minimum mortality , by local climate , age group , sex and medical cause of death .",
"We used geo-coded mortality data and wavelets to analyse the seaso... | [
"In the USA , more deaths happen in the winter than the summer .",
"But when deaths occur varies greatly by sex , age , cause of death , and possibly region .",
"Seasonal differences in death rates can change over time due to changes in factors that cause disease or affect treatment .",
"Analyzing the seasona... | 2018 |
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"microbiology and infectious disease",
"immunology and inflammation"
] | Complement and CD4+ T cells drive context-specific corneal sensory neuropathy | elife-48378-v2 | [
[
"Dysregulated complement activation is increasingly recognized as a significant pathological event in a variety of neurodegenerative and neuroinflammatory diseases of the central nervous system ( Tenner et al . , 2018 ) .",
"These include conditions from Alzheimer’s disease and age-related macular degener... | [
"Whether complement dysregulation directly contributes to the pathogenesis of peripheral nervous system diseases , including sensory neuropathies , is unclear .",
"We addressed this important question in a mouse model of ocular HSV-1 infection , where sensory nerve damage is a common clinical problem .",
"Throu... | [
"Most people have likely experienced the discomfort of an eyelash falling onto the surface of their eye .",
"Or that gritty sensation when dust blows into the eye and irritates the surface .",
"These sensations are warnings from sensory nerves in the cornea , the transparent tissue that covers the iris and pupi... | 2019 |
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"microbiology and infectious disease",
"immunology and inflammation"
] | Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection | elife-04494-v1 | [
[
"HOIL-1 ( encoded by the RBCK1 gene ) , HOIP ( RNF31 ) and SHARPIN form the linear ubiquitin chain assembly complex ( LUBAC ) , which linearly ubiquitinates receptor signaling complex components such as NEMO to enhance NF-κB activation after engagement of immune receptors including TNF-R1 , IL-1R , CD40 , TLR... | [
"Variation in the presentation of hereditary immunodeficiencies may be explained by genetic or environmental factors .",
"Patients with mutations in HOIL1 ( RBCK1 ) present with amylopectinosis-associated myopathy with or without hyper-inflammation and immunodeficiency .",
"We report that barrier-raised HOIL-1-... | [
"The immune system protects an individual from invading bacteria , viruses and parasites , as well as malfunctioning or cancerous host cells .",
"However , some people inherit genetic defects that cause part of the immune system to be missing or to not work properly .",
"This is called a genetic immunodeficienc... | 2015 |
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"neuroscience"
] | Cascade of neural processing orchestrates cognitive control in human frontal cortex | elife-12352-v2 | [["Flexible control of cognitive processes is fundamental to daily activities , including the execut(...TRUNCATED) | ["Rapid and flexible interpretation of conflicting sensory inputs in the context of current goals is(...TRUNCATED) | ["The brain adapts to control our behavior in different ways depending on the specific situation , w(...TRUNCATED) | 2016 |
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"structural biology and molecular biophysics"
] | "Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering mic(...TRUNCATED) | elife-05413-v2 | [["Myosin 5a moves in a hand-over-hand fashion with individual heads moving by 74 nm and the center (...TRUNCATED) | ["Myosin 5a is a dual-headed molecular motor that transports cargo along actin filaments .","By foll(...TRUNCATED) | ["Cells use motor proteins that to move organelles and other cargos from one place to another .","Th(...TRUNCATED) | 2015 |
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"microbiology and infectious disease"
] | Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir | elife-60933-v1 | [["Combination antiretroviral therapy ( ART ) suppresses HIV replication but does not eliminate the (...TRUNCATED) | ["The latent reservoir is a major barrier to HIV cure .","As latently infected cells cannot be pheno(...TRUNCATED) | ["There is no cure for the human immunodeficiency virus infection ( HIV ) , but anti-retroviral drug(...TRUNCATED) | 2020 |
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"ecology",
"computational and systems biology"
] | Tree crickets optimize the acoustics of baffles to exaggerate their mate-attraction signal | elife-32763-v2 | [["Animals produce conspicuous intraspecific communication signals whose intensity is maximised thro(...TRUNCATED) | ["Object manufacture in insects is typically inherited , and believed to be highly stereotyped .","O(...TRUNCATED) | ["Male tree crickets produce sounds at a specific pitch to attract females .","The louder the call ,(...TRUNCATED) | 2017 |
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"neuroscience"
] | "Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects d(...TRUNCATED) | elife-17834-v2 | [["IBMPFD is an autosomal dominant disease that afflicts multiple body systems ( Kimonis et al . , 2(...TRUNCATED) | ["Missense mutations of valosin-containing protein ( VCP ) cause an autosomal dominant disease known(...TRUNCATED) | ["A disease called “inclusion body myopathy , Paget disease and frontotemporal dementia ( IBMPFD )(...TRUNCATED) | 2017 |
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"structural biology and molecular biophysics",
"microbiology and infectious disease"
] | Structural basis of malodour precursor transport in the human axilla | elife-34995-v2 | [["In Homo sapiens the skin of the underarm ( axilla ) provides a unique niche for bacteria .","Thr(...TRUNCATED) | ["Mammals produce volatile odours that convey different types of societal information .","In Homo sa(...TRUNCATED) | ["Human body odour contains a number of chemicals , but the most pungent and recognisable are thioal(...TRUNCATED) | 2018 |
[
"Introduction",
"Results",
"Discussion",
"Materials and methods"
] | [
"cell biology",
"immunology and inflammation"
] | Immune surveillance of the lung by migrating tissue monocytes | elife-07847-v2 | [["The mononuclear phagocytic system ( MPS ) consists of a family of cells—including monocytes , m(...TRUNCATED) | ["Monocytes are phagocytic effector cells in the blood and precursors of resident and inflammatory t(...TRUNCATED) | ["White blood cells form part of the immune system , which protects the body against infectious dise(...TRUNCATED) | 2015 |
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