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Card restructure: symmetric two-views design (no primary/secondary), shared Data Model + How-Built combined, forward-compatible 'a supplement' phrasing for survival_derived, trimmed disclaimer.

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@@ -145,81 +145,81 @@ configs:
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  # TCGA Patients (Open Access)
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- Open-access TCGA data from the NCI Genomic Data Commons (GDC), reshaped as
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- one HuggingFace (HF) subset per TCGA project; one row per patient. Covers
150
  all 33 TCGA projects.
151
 
152
- - **Generated:** 2026-05-09 20:13:48 UTC
 
 
153
  - **Schema:** derived from the [GDC Data Dictionary][gdc-dict].
154
  - **GDC data release:** Data Release 45.0 - December 04, 2025
155
 
156
  ## Data model
157
 
158
- Closely follows the GDC data model — see the [GDC Data Dictionary][gdc-dict]
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- for the canonical entity-by-entity definitions. Each row is one `case` (one
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- patient) with the full biospecimen subtree:
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-
162
- ```
163
- case one patient (TCGA-XX-1234)
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- └── sample physical specimen taken from the patient at one timepoint
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- (Primary Tumor, Solid Tissue Normal, Blood Derived Normal, ...)
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- └── portion a piece of that sample for a specific lab process
167
- └── analyte extracted material of one type (DNA or RNA)
168
- └── aliquot a vial of that analyte handed off for sequencing
169
- ```
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-
171
-
172
- ### Where this dataset deviates from the GDC
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-
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- The few places this row layout differs from a direct mapping of the GDC `case`
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- tree:
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-
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- - **Top-level convenience columns.** Each row carries `gdc_portal_url`
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- (templated link to the patient's GDC Data Portal page) and
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- `samples_<gdc_data_type_snake_case>` molecular vectors (e.g.
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- `samples_masked_somatic_mutation`,
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- `samples_gene_expression_quantification`). These let consumers
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- column-project just the modalities they need; each entry carries foreign
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- keys (FKs) back to `samples[].portions[].analytes[].aliquots[]`.
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- - **Resolved sample FKs on Mutation Annotation Format (MAF) rows.** The GDC
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- ships MAF variants with aliquot UUIDs in `Tumor_Sample_UUID` /
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- `Matched_Norm_Sample_UUID`; we additionally resolve those to
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- `tumor_sample_id` / `matched_normal_sample_id` so consumers can join
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- straight to `samples[]`.
189
- - **Stranded RNA-Seq columns dropped.** Each Gene Expression record drops
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- `stranded_first` / `stranded_second`; the GDC pipeline [harmonizes
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- RNA-Seq reads as
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- unstranded](https://docs.gdc.cancer.gov/Data/Bioinformatics_Pipelines/Expression_mRNA_Pipeline/),
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- so `unstranded` is the canonical column.
194
 
195
- ## How this dataset was built
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-
197
- Every row originates in the NCI Genomic Data Commons (GDC). Three
198
- sources feed each project's data:
199
 
200
  - **Case-level clinical structure** — fetched from the GDC `/cases`
201
  endpoint, returning the full nested case JSON (demographic + diagnoses
202
  → treatments + follow_ups + exposures + family_histories + samples →
203
- portions → analytes → aliquots).
 
 
 
 
 
 
 
 
 
 
204
  - **Per-modality molecular files** — discovered via `/files` (filtered
205
  by the clauses in the table below) and downloaded via `/data`. Each
206
- combination locks one `data_type` to a specific GDC pipeline so future
207
- GDC additions can't silently ship different content under the same
208
- `data_type`.
209
- - **BCR Clinical Supplement files** — original Biospecimen Core Resource
210
- (BCR) clinical biotab forms (per-project TSVs: patient, follow_up,
211
- nte, drug, radiation, etc.). The harmonized `/cases` endpoint drops
212
- or under-populates a number of clinical fields that the BCR-original
213
- biotabs preserve most importantly Liu et al. 2018's
214
- `treatment_outcome_first_course`, used by `survival_derived`.
215
- Discovered via `/files` filtered to `data_type="Clinical Supplement"`
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- + `data_format="bcr biotab"`, downloaded via `/data`.
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-
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- | Lands at | data_type | data_format | data_category | experimental_strategy | analysis.workflow_type |
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- |---|---|---|---|---|---|
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- | `samples_masked_somatic_mutation` array | `Masked Somatic Mutation` | `MAF` | `Simple Nucleotide Variation` | `WXS` | `Aliquot Ensemble Somatic Variant Merging and Masking` |
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- | `samples_gene_expression_quantification` array | `Gene Expression Quantification` | `TSV` | `Transcriptome Profiling` | `RNA-Seq` | `STAR - Counts` |
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- | consumed in-memory for `survival_derived` | `Clinical Supplement` | `bcr biotab` | `Clinical` | | |
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
223
 
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  ### Provenance pinned per build
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@@ -232,17 +232,18 @@ sources feed each project's data:
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  See the [repository][repo] for full request payloads, filter clauses,
233
  and the build pipeline source.
234
 
 
235
  ## Survival endpoints (`survival_derived`)
236
 
237
- The only value-added enrichment in this dataset. Four standard survival
238
- endpoints — Overall Survival (OS), Disease-Specific Survival (DSS),
239
- Progression-Free Interval (PFI), Disease-Free Interval (DFI) — re-derived
240
- from the current GDC data using the algorithm from **Liu et al. 2018**
241
  ([DOI 10.1016/j.cell.2018.02.052](https://doi.org/10.1016/j.cell.2018.02.052)).
242
 
243
- Each patient row carries a top-level **`survival_derived` struct** with eight sub-fields: `os_event` / `os_time`, `dss_event` / `dss_time`, `pfi_event` / `pfi_time`, `dfi_event` / `dfi_time`. `*_event` is 0/1 (event observed vs censored); `*_time` is days
244
- from `index_date` (TCGA: diagnosis date). DFI is null for SKCM / THYM /
245
- UVM / LAML — Liu specifies no DFI for those tumor types.
246
 
247
  We've reimplemented Liu's method against the current TCGA data and find
248
  broad agreement with the original curated CDR. Differences exist and are
@@ -253,25 +254,23 @@ migrations all contribute to the gap. This work is evolving; see the
253
  methodology.
254
 
255
  **Why we don't ship Liu's curated 2018 values directly:** the CDR is a
256
- frozen 2018 snapshot derived from a since-modified GDC release. Including
257
- those values would lock in irreproducible source-data drift. We re-derive
258
- on every build, so the values reflect the current GDC and are reproducible
259
- from this dataset's other tables alone.
260
 
261
  ## Loading
262
 
263
- The [`tcga2hf` package][repo] ships a typed `TcgaHfPatient` pydantic model
264
- that mirrors this schema and adds convenience joins (tumor/normal pairs,
265
- mutations-by-gene, expression-by-gene, longitudinal timeline).
266
-
267
  ```python
268
- import pyarrow.parquet as pq
269
- from tcga2hf.models import TcgaHfPatient
270
 
271
- t = pq.read_table("TCGA-CHOL/data.parquet")
272
- patients = [TcgaHfPatient.model_validate(r) for r in t.to_pylist()]
273
  ```
274
 
 
 
 
275
  ## GDC references
276
 
277
  - [Data dictionary][gdc-dict] (every entity + field definition)
@@ -332,11 +331,9 @@ Policy references:
332
 
333
  **This project is not affiliated with the NCI, GDC, or the TCGA Research
334
  Network.** It is an experimental open-source pipeline that may change
335
- significantly between versions; pin the GDC release and dataset commit
336
- if you depend on a specific snapshot. Re-derive from the GDC for any
337
- analysis where freshness matters — the dataset reflects the GDC release
338
- pinned in each project's `gdc_status.json`. Pipeline source:
339
- [`galtay/tcga2hf`][repo].
340
 
341
  [gdc-dict]: https://docs.gdc.cancer.gov/Data_Dictionary/
342
  [repo]: https://github.com/galtay/tcga2hf
 
 
 
145
 
146
  # TCGA Patients (Open Access)
147
 
148
+ Open-access TCGA data from the NCI Genomic Data Commons (GDC). Covers
 
149
  all 33 TCGA projects.
150
 
151
+ **This view presents one HuggingFace subset per TCGA project**, with one row per patient. See the [`tcga-tabular-open`][tabular] companion for a per-table view of the same underlying data.
152
+
153
+ - **Generated:** 2026-05-09 21:21:40 UTC
154
  - **Schema:** derived from the [GDC Data Dictionary][gdc-dict].
155
  - **GDC data release:** Data Release 45.0 - December 04, 2025
156
 
157
  ## Data model
158
 
159
+ ### Where the data comes from
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
160
 
161
+ Three sources feed each project's data, all open-access:
 
 
 
162
 
163
  - **Case-level clinical structure** — fetched from the GDC `/cases`
164
  endpoint, returning the full nested case JSON (demographic + diagnoses
165
  → treatments + follow_ups + exposures + family_histories + samples →
166
+ portions → analytes → aliquots). The biospecimen subtree on each case:
167
+
168
+ ```
169
+ case one patient (TCGA-XX-1234)
170
+ └── sample physical specimen taken from the patient at one timepoint
171
+ (Primary Tumor, Solid Tissue Normal, Blood Derived Normal, ...)
172
+ └── portion a piece of that sample for a specific lab process
173
+ └── analyte extracted material of one type (DNA or RNA)
174
+ └── aliquot a vial of that analyte handed off for sequencing
175
+ ```
176
+
177
  - **Per-modality molecular files** — discovered via `/files` (filtered
178
  by the clauses in the table below) and downloaded via `/data`. Each
179
+ combination locks one `data_type` to a specific GDC pipeline so a
180
+ future GDC addition can't quietly substitute a different pipeline
181
+ under the same `data_type`.
182
+ - **BCR Clinical Supplement biotabs** — original Biospecimen Core
183
+ Resource (BCR) clinical forms shipped as per-project TSVs (one per
184
+ form: patient, follow_up, nte, drug, radiation, etc.). The harmonized
185
+ `/cases` endpoint drops or under-populates a number of clinical fields
186
+ the BCR-original biotabs preserve. The schema varies by cancer type
187
+ (e.g. BLCA's BCG-response columns don't exist in CHOL's hepatic-marker
188
+ forms), so each project's biotabs ship only the columns they actually
189
+ carry. Discovered via `/files` filtered to `data_type="Clinical
190
+ Supplement"` + `data_format="bcr biotab"`, downloaded via `/data`.
191
+
192
+ ### Source data filters (canonical)
193
+
194
+ Same in both views of the dataset; each row locks the `/files` query
195
+ for one source:
196
+
197
+ | data_type | data_format | data_category | experimental_strategy | analysis.workflow_type |
198
+ |---|---|---|---|---|
199
+ | `Masked Somatic Mutation` | `MAF` | `Simple Nucleotide Variation` | `WXS` | `Aliquot Ensemble Somatic Variant Merging and Masking` |
200
+ | `Gene Expression Quantification` | `TSV` | `Transcriptome Profiling` | `RNA-Seq` | `STAR - Counts` |
201
+ | `Clinical Supplement` | `bcr biotab` | `Clinical` | | |
202
+
203
+ ### How each source appears in this view
204
+
205
+ | Source | Where it lands |
206
+ |---|---|
207
+ | GDC `/cases` | nested fields on each patient row (`demographic`, `diagnoses`, `follow_ups`, `exposures`, `family_histories`, `samples`); `gdc_portal_url` link added |
208
+ | Masked Somatic Mutation MAFs | `samples_masked_somatic_mutation` array on each patient row (sample FKs resolved alongside GDC's aliquot UUIDs) |
209
+ | Gene Expression Quantification | `samples_gene_expression_quantification` array on each patient row (`stranded_first` / `stranded_second` dropped — GDC harmonizes as unstranded) |
210
+ | BCR Clinical Supplements | consumed in-memory for the `survival_derived` supplement (see below); not surfaced as columns on the row |
211
+
212
+
213
+ ### Specific to this view
214
+
215
+ - Convenience: each row carries `samples_<modality>` array columns so
216
+ you can column-project just the molecular data you need without
217
+ walking the nested GDC entities.
218
+ - Loading: the [`tcga2hf` package][repo] ships a typed `TcgaHfPatient`
219
+ pydantic model that mirrors this schema and adds convenience joins
220
+ (tumor/normal pairs, mutations-by-gene, expression-by-gene,
221
+ longitudinal timeline).
222
+
223
 
224
  ### Provenance pinned per build
225
 
 
232
  See the [repository][repo] for full request payloads, filter clauses,
233
  and the build pipeline source.
234
 
235
+
236
  ## Survival endpoints (`survival_derived`)
237
 
238
+ We have provided a supplement to the GDC source data: re-derived
239
+ survival endpoints — Overall Survival (OS), Disease-Specific Survival
240
+ (DSS), Progression-Free Interval (PFI), Disease-Free Interval (DFI) —
241
+ following the algorithm published by **Liu et al. 2018**
242
  ([DOI 10.1016/j.cell.2018.02.052](https://doi.org/10.1016/j.cell.2018.02.052)).
243
 
244
+ Each patient row carries a top-level **`survival_derived` struct** with eight sub-fields: `os_event` / `os_time`, `dss_event` / `dss_time`, `pfi_event` / `pfi_time`, `dfi_event` / `dfi_time`. `*_event` is 0/1 (event observed vs censored); `*_time` is
245
+ days from `index_date` (TCGA: diagnosis date). DFI is null for SKCM /
246
+ THYM / UVM / LAML — Liu specifies no DFI for those tumor types.
247
 
248
  We've reimplemented Liu's method against the current TCGA data and find
249
  broad agreement with the original curated CDR. Differences exist and are
 
254
  methodology.
255
 
256
  **Why we don't ship Liu's curated 2018 values directly:** the CDR is a
257
+ frozen 2018 snapshot derived from a since-modified GDC release.
258
+ Including those values would lock in irreproducible source-data drift.
259
+ We re-derive on every build, so the values reflect the current GDC and
260
+ are reproducible from this dataset's other tables alone.
261
 
262
  ## Loading
263
 
 
 
 
 
264
  ```python
265
+ from datasets import load_dataset
 
266
 
267
+ # One config per TCGA project.
268
+ luad = load_dataset("gabrielaltay/tcga-patients-open", "TCGA-LUAD")
269
  ```
270
 
271
+ Each row is one patient with the full GDC `case` structure nested
272
+ in-place plus the `survival_derived` struct.
273
+
274
  ## GDC references
275
 
276
  - [Data dictionary][gdc-dict] (every entity + field definition)
 
331
 
332
  **This project is not affiliated with the NCI, GDC, or the TCGA Research
333
  Network.** It is an experimental open-source pipeline that may change
334
+ significantly between versions. Pipeline source: [`galtay/tcga2hf`][repo].
 
 
 
 
335
 
336
  [gdc-dict]: https://docs.gdc.cancer.gov/Data_Dictionary/
337
  [repo]: https://github.com/galtay/tcga2hf
338
+ [patients]: https://huggingface.co/datasets/gabrielaltay/tcga-patients-open
339
+ [tabular]: https://huggingface.co/datasets/gabrielaltay/tcga-tabular-open