id
string
sources
list
title
string
abstract
string
authors
list
categories
list
fields_of_study
list
published_date
timestamp[s]
url
string
pdf_url
string
arxiv_id
string
doi
string
citation_count
int64
influential_citation_count
int64
has_code
bool
code_url
string
venue
string
quality_score
float64
a0b7cc577019d1575ad631664c31136505b36d6e08d9c62369f9516a5113e6e7
[ "arxiv", "semantic_scholar" ]
PatchProt: Hydrophobic patch prediction using protein foundation models
Hydrophobic patches on protein surfaces play important functional roles in protein-protein and protein-ligand interactions. Large hydrophobic surfaces are also involved in the progression of aggregation diseases. Predicting exposed hydrophobic patches from a protein sequence has been shown to be a difficult task. Fine-...
[ "Dea Gogishvili", "Emmanuel Minois-Genin", "Jan van Eck", "Sanne Abeln" ]
[ "q-bio.QM", "cs.AI", "cs.LG" ]
[ "Biology", "Computer Science", "Medicine" ]
2024-05-24T00:00:00
https://arxiv.org/abs/2405.15928
https://arxiv.org/pdf/2405.15928v1
2405.15928
10.1093/bioadv/vbae154
6
0
false
null
Bioinformatics Advances
0.2113
70122fc9f0338bf385215485ac3fa710996065401d7bd83abdab3517d8eb2ba0
[ "arxiv", "semantic_scholar" ]
Learning the Language of Protein Structure
Representation learning and \emph{de novo} generation of proteins are pivotal computational biology tasks. Whilst natural language processing (NLP) techniques have proven highly effective for protein sequence modelling, structure modelling presents a complex challenge, primarily due to its continuous and three-dimensio...
[ "Benoit Gaujac", "Jérémie Donà", "Liviu Copoiu", "Timothy Atkinson", "Thomas Pierrot", "Thomas D. Barrett" ]
[ "q-bio.QM", "cs.LG" ]
[ "Computer Science", "Biology" ]
2024-05-24T00:00:00
https://arxiv.org/abs/2405.15840
https://arxiv.org/pdf/2405.15840v2
2405.15840
10.48550/arXiv.2405.15840
17
1
false
null
null
0.3138
71d2f676af919902dbd3ee3ab6e0affdfbe5ab43b26320eb6033f12732353e22
[ "arxiv", "semantic_scholar" ]
Babysit A Language Model From Scratch: Interactive Language Learning by Trials and Demonstrations
Humans are efficient language learners and inherently social creatures. Our language development is largely shaped by our social interactions, for example, the demonstration and feedback from caregivers. Contrary to human language learning, recent advancements in large language models have primarily adopted a non-inter...
[ "Ziqiao Ma", "Zekun Wang", "Joyce Chai" ]
[ "cs.CL", "cs.AI" ]
[ "Computer Science" ]
2024-05-22T00:00:00
https://arxiv.org/abs/2405.13828
https://arxiv.org/pdf/2405.13828v2
2405.13828
10.48550/arXiv.2405.13828
14
0
false
null
North American Chapter of the Association for Computational Linguistics
0.294
3ae1698ce8c0a871547135b6242855a4ebb9129b0fe0085882bba33e307ab8c3
[ "arxiv", "semantic_scholar" ]
Identifying the minimal sets of distance restraints for FRET-assisted protein structural modeling
Proteins naturally occur in crowded cellular environments and interact with other proteins, nucleic acids, and organelles. Since most previous experimental protein structure determination techniques require that proteins occur in idealized, non-physiological environments, the effects of realistic cellular environments ...
[ "Zhuoyi Liu", "Alex T. Grigas", "Jacob Sumner", "Edward Knab", "Caitlin M. Davis", "Corey S. O'Hern" ]
[ "physics.bio-ph", "q-bio.BM" ]
[ "Physics", "Biology", "Medicine" ]
2024-05-13T00:00:00
https://arxiv.org/abs/2405.07983
https://arxiv.org/pdf/2405.07983v2
2405.07983
10.1002/pro.5219
0
0
false
null
Protein Science
0
27aa4f17a5d75f6efa1677455377ada76e922dcabfe586039b56b09597bef78d
[ "arxiv", "semantic_scholar" ]
Fine-tuning Protein Language Models with Deep Mutational Scanning improves Variant Effect Prediction
Protein Language Models (PLMs) have emerged as performant and scalable tools for predicting the functional impact and clinical significance of protein-coding variants, but they still lag experimental accuracy. Here, we present a novel fine-tuning approach to improve the performance of PLMs with experimental maps of var...
[ "Aleix Lafita", "Ferran Gonzalez", "Mahmoud Hossam", "Paul Smyth", "Jacob Deasy", "Ari Allyn-Feuer", "Daniel Seaton", "Stephen Young" ]
[ "q-bio.GN", "cs.LG" ]
[ "Computer Science", "Biology" ]
2024-05-10T00:00:00
https://arxiv.org/abs/2405.06729
https://arxiv.org/pdf/2405.06729v1
2405.06729
10.48550/arXiv.2405.06729
16
2
false
null
arXiv.org
0.3076
e8e9616cc1ca90d9351412243e1e3a9787ea28c3e7130bdb0c637635c1158e0c
[ "arxiv", "semantic_scholar" ]
Protein binding affinity prediction under multiple substitutions applying eGNNs on Residue and Atomic graphs combined with Language model information: eGRAL
Protein-protein interactions (PPIs) play a crucial role in numerous biological processes. Developing methods that predict binding affinity changes under substitution mutations is fundamental for modelling and re-engineering biological systems. Deep learning is increasingly recognized as a powerful tool capable of bridg...
[ "Arturo Fiorellini-Bernardis", "Sebastien Boyer", "Christoph Brunken", "Bakary Diallo", "Karim Beguir", "Nicolas Lopez-Carranza", "Oliver Bent" ]
[ "q-bio.QM", "cs.AI", "cs.LG" ]
[ "Biology", "Computer Science" ]
2024-05-03T00:00:00
https://arxiv.org/abs/2405.02374
https://arxiv.org/pdf/2405.02374v1
2405.02374
10.48550/arXiv.2405.02374
1
0
false
null
arXiv.org
0.0753
bd9fa1e533ac60d118af2ff6e4816192fd52a4d2e0bca7b7b99b1e5c7671df31
[ "arxiv", "semantic_scholar" ]
Detection of circular permutations by Protein Language Models
Protein circular permutations are crucial for understanding protein evolution and functionality. Traditional detection methods, sequence-based or structure-based, struggle with accuracy and computational efficiency, the latter also limited by treating proteins as rigid bodies. The plmCP method, utilizing a protein lang...
[ "Yue Hu", "Bin Huang", "Chunzi Zang" ]
[ "q-bio.QM" ]
[ "Medicine", "Biology" ]
2024-04-23T00:00:00
https://arxiv.org/abs/2404.15087
https://arxiv.org/pdf/2404.15087v2
2404.15087
10.1016/j.csbj.2024.12.029
1
0
false
null
Computational and Structural Biotechnology Journal
0.0753
3178545dea9826a95d7ef4b463c338df7ae9d07165c419654c9276ae6c49d870
[ "arxiv", "semantic_scholar" ]
Simple, Efficient and Scalable Structure-aware Adapter Boosts Protein Language Models
Fine-tuning Pre-trained protein language models (PLMs) has emerged as a prominent strategy for enhancing downstream prediction tasks, often outperforming traditional supervised learning approaches. As a widely applied powerful technique in natural language processing, employing Parameter-Efficient Fine-Tuning technique...
[ "Yang Tan", "Mingchen Li", "Bingxin Zhou", "Bozitao Zhong", "Lirong Zheng", "Pan Tan", "Ziyi Zhou", "Huiqun Yu", "Guisheng Fan", "Liang Hong" ]
[ "cs.CL", "cs.LG", "q-bio.BM" ]
[ "Computer Science", "Biology", "Medicine" ]
2024-04-23T00:00:00
https://arxiv.org/abs/2404.14850
https://arxiv.org/pdf/2404.14850v1
2404.14850
10.48550/arXiv.2404.14850
21
0
true
https://github.com/tyang816/SES-Adapter
Journal of Chemical Information and Modeling
0.3356
82bac94f1ebc01f0031e52a53e4916ee4a3feb7c0e0d19033e465a62b854845d
[ "arxiv", "semantic_scholar" ]
ScaleFold: Reducing AlphaFold Initial Training Time to 10 Hours
AlphaFold2 has been hailed as a breakthrough in protein folding. It can rapidly predict protein structures with lab-grade accuracy. However, its implementation does not include the necessary training code. OpenFold is the first trainable public reimplementation of AlphaFold. AlphaFold training procedure is prohibitivel...
[ "Feiwen Zhu", "Arkadiusz Nowaczynski", "Rundong Li", "Jie Xin", "Yifei Song", "Michal Marcinkiewicz", "Sukru Burc Eryilmaz", "Jun Yang", "Michael Andersch" ]
[ "cs.LG", "cs.AI", "cs.DC", "q-bio.QM" ]
[ "Computer Science", "Biology" ]
2024-04-17T00:00:00
https://arxiv.org/abs/2404.11068
https://arxiv.org/pdf/2404.11068v1
2404.11068
10.1145/3649329.3657326
11
0
false
null
Design Automation Conference
0.2698
2e66784743ed2c15fd4452170a70c0787c82369075458d2d53884a6d81f0c93e
[ "arxiv", "semantic_scholar" ]
HelixFold-Multimer: Elevating Protein Complex Structure Prediction to New Heights
While monomer protein structure prediction tools boast impressive accuracy, the prediction of protein complex structures remains a daunting challenge in the field. This challenge is particularly pronounced in scenarios involving complexes with protein chains from different species, such as antigen-antibody interactions...
[ "Xiaomin Fang", "Jie Gao", "Jing Hu", "Lihang Liu", "Yang Xue", "Xiaonan Zhang", "Kunrui Zhu" ]
[ "q-bio.BM", "cs.AI" ]
[ "Computer Science", "Biology" ]
2024-04-16T00:00:00
https://arxiv.org/abs/2404.10260
https://arxiv.org/pdf/2404.10260v2
2404.10260
10.48550/arXiv.2404.10260
14
1
false
null
arXiv.org
0.294
ea062e2411156c0d3caa22f40dafc93738cd42fbcaf81582356fd02b79a16076
[ "arxiv", "semantic_scholar" ]
PRODIS -- a speech database and a phoneme-based language model for the study of predictability effects in Polish
We present a speech database and a phoneme-level language model of Polish. The database and model are designed for the analysis of prosodic and discourse factors and their impact on acoustic parameters in interaction with predictability effects. The database is also the first large, publicly available Polish speech cor...
[ "Zofia Malisz", "Jan Foremski", "Małgorzata Kul" ]
[ "cs.CL", "cs.SD", "eess.AS" ]
[ "Computer Science", "Engineering" ]
2024-04-15T00:00:00
https://arxiv.org/abs/2404.10112
https://arxiv.org/pdf/2404.10112v1
2404.10112
10.48550/arXiv.2404.10112
1
0
false
null
International Conference on Language Resources and Evaluation
0.0753
12bb9962964829e2930b933f77322bdfffdc9979d32f6509b3d9ba2fefb95c37
[ "arxiv", "semantic_scholar" ]
Auxiliary task demands mask the capabilities of smaller language models
Developmental psychologists have argued about when cognitive capacities such as language understanding or theory of mind emerge. These debates often hinge on the concept of "task demands" -- the auxiliary challenges associated with performing a particular evaluation -- that may mask the child's underlying ability. The ...
[ "Jennifer Hu", "Michael C. Frank" ]
[ "cs.CL", "cs.AI" ]
[ "Computer Science" ]
2024-04-03T00:00:00
https://arxiv.org/abs/2404.02418
https://arxiv.org/pdf/2404.02418v2
2404.02418
10.48550/arXiv.2404.02418
62
3
false
null
arXiv.org
0.4498
66acb8541b33578b36663425d587945f09653793619d871d74cc701ba2bb2bba
[ "arxiv", "semantic_scholar" ]
ProLLM: Protein Chain-of-Thoughts Enhanced LLM for Protein-Protein Interaction Prediction
The prediction of protein-protein interactions (PPIs) is crucial for understanding biological functions and diseases. Previous machine learning approaches to PPI prediction mainly focus on direct physical interactions, ignoring the broader context of nonphysical connections through intermediate proteins, thus limiting ...
[ "Mingyu Jin", "Haochen Xue", "Zhenting Wang", "Boming Kang", "Ruosong Ye", "Kaixiong Zhou", "Mengnan Du", "Yongfeng Zhang" ]
[ "q-bio.BM", "cs.LG", "q-bio.MN" ]
[ "Biology", "Computer Science" ]
2024-03-30T00:00:00
https://arxiv.org/abs/2405.06649
https://arxiv.org/pdf/2405.06649v2
2405.06649
10.1101/2024.04.18.590025
35
0
true
https://github.com/MingyuJ666/ProLLM
bioRxiv
0.3891
e7a4c05fe267c4a25bd9ae4c2c68e3a040840bc2e647b6cafb71fa1342ac3e93
[ "arxiv", "semantic_scholar" ]
IDP-Bert: Predicting Properties of Intrinsically Disordered Proteins (IDP) Using Large Language Models
Intrinsically Disordered Proteins (IDPs) constitute a large and structure-less class of proteins with significant functions. The existence of IDPs challenges the conventional notion that the biological functions of proteins rely on their three-dimensional structures. Despite lacking well-defined spatial arrangements, t...
[ "Parisa Mollaei", "Danush Sadasivam", "Chakradhar Guntuboina", "Amir Barati Farimani" ]
[ "q-bio.BM" ]
[ "Medicine", "Biology" ]
2024-03-28T00:00:00
https://arxiv.org/abs/2403.19762
https://arxiv.org/pdf/2403.19762v2
2403.19762
10.1021/acs.jpcb.4c02507
10
0
false
null
Journal of Physical Chemistry B
0.2603
79e2e96fd884323e4fb0ed5426f8afc7b716b92f7a54400662b72aef932b8b45
[ "arxiv", "semantic_scholar" ]
Are Compressed Language Models Less Subgroup Robust?
To reduce the inference cost of large language models, model compression is increasingly used to create smaller scalable models. However, little is known about their robustness to minority subgroups defined by the labels and attributes of a dataset. In this paper, we investigate the effects of 18 different compression ...
[ "Leonidas Gee", "Andrea Zugarini", "Novi Quadrianto" ]
[ "cs.LG", "cs.CL" ]
[ "Computer Science" ]
2024-03-26T00:00:00
https://arxiv.org/abs/2403.17811
https://arxiv.org/pdf/2403.17811v1
2403.17811
10.18653/v1/2023.emnlp-main.983
2
0
false
null
Conference on Empirical Methods in Natural Language Processing
0.1193
f13a3031b7e1b19d233f29125e0d9d81ff088cb8330048b9c0dd1024e2bf25a7
[ "arxiv", "semantic_scholar" ]
Emergent World Models and Latent Variable Estimation in Chess-Playing Language Models
Language models have shown unprecedented capabilities, sparking debate over the source of their performance. Is it merely the outcome of learning syntactic patterns and surface level statistics, or do they extract semantics and a world model from the text? Prior work by Li et al. investigated this by training a GPT mod...
[ "Adam Karvonen" ]
[ "cs.LG", "cs.CL" ]
[ "Computer Science" ]
2024-03-21T00:00:00
https://arxiv.org/abs/2403.15498
https://arxiv.org/pdf/2403.15498v2
2403.15498
10.48550/arXiv.2403.15498
59
2
false
null
arXiv.org
0.4445
5cf25741665611e22072be9eb97db4afa25dc5927046a6b41539586549068b00
[ "arxiv", "semantic_scholar" ]
Clinical information extraction for Low-resource languages with Few-shot learning using Pre-trained language models and Prompting
Automatic extraction of medical information from clinical documents poses several challenges: high costs of required clinical expertise, limited interpretability of model predictions, restricted computational resources and privacy regulations. Recent advances in domain-adaptation and prompting methods showed promising ...
[ "Phillip Richter-Pechanski", "Philipp Wiesenbach", "Dominic M. Schwab", "Christina Kiriakou", "Nicolas Geis", "Christoph Dieterich", "Anette Frank" ]
[ "cs.CL", "cs.AI", "cs.LG" ]
[ "Computer Science" ]
2024-03-20T00:00:00
https://arxiv.org/abs/2403.13369
https://arxiv.org/pdf/2403.13369v2
2403.13369
10.1017/nlp.2024.52
12
0
false
null
Natural Language Processing
0.2785
5906bbc9c25873cbc482ed652fd00b99c63697c63b94defd62768fe697692e1d
[ "arxiv", "semantic_scholar" ]
Document Author Classification Using Parsed Language Structure
Over the years there has been ongoing interest in detecting authorship of a text based on statistical properties of the text, such as by using occurrence rates of noncontextual words. In previous work, these techniques have been used, for example, to determine authorship of all of \emph{The Federalist Papers}. Such met...
[ "Todd K Moon", "Jacob H. Gunther" ]
[ "cs.CL", "eess.AS" ]
[ "Computer Science", "Engineering" ]
2024-03-20T00:00:00
https://arxiv.org/abs/2403.13253
https://arxiv.org/pdf/2403.13253v1
2403.13253
10.5121/ijnlc.2024.13104
0
0
false
null
International Journal on Natural Language Computing
0
85e0b9ee143f1fcc602843116f647c2421c54521c54cbd63c84b4e8d608feda1
[ "arxiv", "semantic_scholar" ]
Pragmatic Competence Evaluation of Large Language Models for the Korean Language
Benchmarks play a significant role in the current evaluation of Large Language Models (LLMs), yet they often overlook the models' abilities to capture the nuances of human language, primarily focusing on evaluating embedded knowledge and technical skills. To address this gap, our study evaluates how well LLMs understan...
[ "Dojun Park", "Jiwoo Lee", "Hyeyun Jeong", "Seohyun Park", "Sungeun Lee" ]
[ "cs.CL" ]
[ "Computer Science" ]
2024-03-19T00:00:00
https://arxiv.org/abs/2403.12675
https://arxiv.org/pdf/2403.12675v2
2403.12675
null
9
0
false
null
Pacific Asia Conference on Language, Information and Computation
0.25
c308ff793346730f430bd9bb7891dc496dbe4dd1d152b39a6e64dc671afd1e2a
[ "arxiv", "semantic_scholar" ]
Language Evolution with Deep Learning
Computational modeling plays an essential role in the study of language emergence. It aims to simulate the conditions and learning processes that could trigger the emergence of a structured language within a simulated controlled environment. Several methods have been used to investigate the origin of our language, incl...
[ "Mathieu Rita", "Paul Michel", "Rahma Chaabouni", "Olivier Pietquin", "Emmanuel Dupoux", "Florian Strub" ]
[ "cs.CL", "cs.MA" ]
[ "Computer Science" ]
2024-03-18T00:00:00
https://arxiv.org/abs/2403.11958
https://arxiv.org/pdf/2403.11958v1
2403.11958
10.48550/arXiv.2403.11958
4
0
false
null
arXiv.org
0.1747
23bf9dbb62f19e2e7d79222f2d0a38475c004cd7f6e6c33bc1d7527e99668ef4
[ "arxiv", "semantic_scholar" ]
On Recovering Higher-order Interactions from Protein Language Models
Protein language models leverage evolutionary information to perform state-of-the-art 3D structure and zero-shot variant prediction. Yet, extracting and explaining all the mutational interactions that govern model predictions remains difficult as it requires querying the entire amino acid space for $n$ sites using $20^...
[ "Darin Tsui", "Amirali Aghazadeh" ]
[ "q-bio.BM", "cs.AI", "cs.LG" ]
[ "Biology", "Computer Science" ]
2024-03-15T00:00:00
https://arxiv.org/abs/2405.06645
https://arxiv.org/pdf/2405.06645v1
2405.06645
10.48550/arXiv.2405.06645
9
0
true
https://github.com/amirgroup-codes/InteractionRecovery
arXiv.org
0.25
81d8ac72001a2f9a2b9ff6141d4704d9d34de13762fb0325af67c9facc5e2fe9
[ "arxiv", "semantic_scholar" ]
Diffusion on language model encodings for protein sequence generation
Protein sequence design has seen significant advances through discrete diffusion and autoregressive approaches, yet the potential of continuous diffusion remains underexplored. Here, we present DiMA, a latent diffusion framework that operates on protein language model representations. Through systematic exploration of ...
[ "Viacheslav Meshchaninov", "Pavel Strashnov", "Andrey Shevtsov", "Fedor Nikolaev", "Nikita Ivanisenko", "Olga Kardymon", "Dmitry Vetrov" ]
[ "cs.LG", "cs.AI", "q-bio.BM" ]
[ "Computer Science", "Biology" ]
2024-03-06T00:00:00
https://arxiv.org/abs/2403.03726
https://arxiv.org/pdf/2403.03726v4
2403.03726
null
25
1
true
https://github.com/MeshchaninovViacheslav/DiMA}{GitHub}
International Conference on Machine Learning
0.3537
627b133b064603a539be91a0e27517549ec47db60c456d6c79068192dd878eae
[ "arxiv", "semantic_scholar" ]
ESM All-Atom: Multi-scale Protein Language Model for Unified Molecular Modeling
Protein language models have demonstrated significant potential in the field of protein engineering. However, current protein language models primarily operate at the residue scale, which limits their ability to provide information at the atom level. This limitation prevents us from fully exploiting the capabilities of...
[ "Kangjie Zheng", "Siyu Long", "Tianyu Lu", "Junwei Yang", "Xinyu Dai", "Ming Zhang", "Zaiqing Nie", "Wei-Ying Ma", "Hao Zhou" ]
[ "q-bio.BM", "cs.CE", "cs.LG" ]
[ "Biology", "Computer Science" ]
2024-03-05T00:00:00
https://arxiv.org/abs/2403.12995
https://arxiv.org/pdf/2403.12995v4
2403.12995
10.1101/2024.03.04.583284
19
1
true
https://github.com/zhengkangjie/ESM-AA
bioRxiv
0.3253
16fe3c2c6abb50260051879d07d2e2f84b992b27d92b039395736072129baf9c
[ "arxiv", "semantic_scholar" ]
A Protein Structure Prediction Approach Leveraging Transformer and CNN Integration
Proteins are essential for life, and their structure determines their function. The protein secondary structure is formed by the folding of the protein primary structure, and the protein tertiary structure is formed by the bending and folding of the secondary structure. Therefore, the study of protein secondary structu...
[ "Yanlin Zhou", "Kai Tan", "Xinyu Shen", "Zheng He", "Haotian Zheng" ]
[ "q-bio.BM", "cs.LG" ]
[ "Computer Science", "Biology" ]
2024-02-29T00:00:00
https://arxiv.org/abs/2402.19095
https://arxiv.org/pdf/2402.19095v2
2402.19095
10.1109/ICAACE61206.2024.10548253
17
0
false
null
null
0.3138
8566277431df6c4de2e60b89887ee89d0def38c46ca1933ed95fa6d808171f0f
[ "arxiv", "semantic_scholar" ]
Protein Multimer Structure Prediction via Prompt Learning
Understanding the 3D structures of protein multimers is crucial, as they play a vital role in regulating various cellular processes. It has been empirically confirmed that the multimer structure prediction~(MSP) can be well handled in a step-wise assembly fashion using provided dimer structures and predicted protein-pr...
[ "Ziqi Gao", "Xiangguo Sun", "Zijing Liu", "Yu Li", "Hong Cheng", "Jia Li" ]
[ "cs.CE" ]
[ "Computer Science" ]
2024-02-29T00:00:00
https://arxiv.org/abs/2402.18813
https://arxiv.org/pdf/2402.18813v1
2402.18813
10.48550/arXiv.2402.18813
16
1
true
https://github.com/zqgao22/PromptMSP}
International Conference on Learning Representations
0.3076
f7ed9611db3d0e691778ac27b501a598a3db0c1ab01301849aecc792b84bbdcf
[ "arxiv", "semantic_scholar" ]
ProtLLM: An Interleaved Protein-Language LLM with Protein-as-Word Pre-Training
We propose ProtLLM, a versatile cross-modal large language model (LLM) for both protein-centric and protein-language tasks. ProtLLM features a unique dynamic protein mounting mechanism, enabling it to handle complex inputs where the natural language text is interspersed with an arbitrary number of proteins. Besides, we...
[ "Le Zhuo", "Zewen Chi", "Minghao Xu", "Heyan Huang", "Heqi Zheng", "Conghui He", "Xian-Ling Mao", "Wentao Zhang" ]
[ "q-bio.BM", "cs.AI", "cs.CL", "cs.LG" ]
[ "Computer Science", "Biology" ]
2024-02-28T00:00:00
https://arxiv.org/abs/2403.07920
https://arxiv.org/pdf/2403.07920v1
2403.07920
10.48550/arXiv.2403.07920
29
3
false
null
Annual Meeting of the Association for Computational Linguistics
0.3693
1db93edbc47a3acd607b4e620e329fa4ed25c4c0dc0f48470727c205b67da618
[ "arxiv", "semantic_scholar" ]
Diffusion Language Models Are Versatile Protein Learners
This paper introduces diffusion protein language model (DPLM), a versatile protein language model that demonstrates strong generative and predictive capabilities for protein sequences. We first pre-train scalable DPLMs from evolutionary-scale protein sequences within a generative self-supervised discrete diffusion prob...
[ "Xinyou Wang", "Zaixiang Zheng", "Fei Ye", "Dongyu Xue", "Shujian Huang", "Quanquan Gu" ]
[ "cs.LG", "q-bio.BM" ]
[ "Computer Science", "Biology" ]
2024-02-28T00:00:00
https://arxiv.org/abs/2402.18567
https://arxiv.org/pdf/2402.18567v2
2402.18567
10.48550/arXiv.2402.18567
130
15
true
https://github.com/bytedance/dplm}
International Conference on Machine Learning
0.6021
2d361a6742ab3b6880d0db2962ed86fa6848d91092645eb75a088e08a9a77af2
[ "arxiv", "semantic_scholar" ]
ProLLaMA: A Protein Large Language Model for Multi-Task Protein Language Processing
Recent advances in Protein Language Models (PLMs) have transformed protein engineering, yet unlike their counterparts in Natural Language Processing (NLP), current PLMs exhibit a fundamental limitation: they excel in either Protein Language Understanding (PLU) or Protein Language Generation (PLG), but rarely both. This...
[ "Liuzhenghao Lv", "Zongying Lin", "Hao Li", "Yuyang Liu", "Jiaxi Cui", "Calvin Yu-Chian Chen", "Li Yuan", "Yonghong Tian" ]
[ "cs.CE", "q-bio.BM" ]
[ "Computer Science", "Biology" ]
2024-02-26T00:00:00
https://arxiv.org/abs/2402.16445
https://arxiv.org/pdf/2402.16445v3
2402.16445
10.1109/TAI.2025.3564914
89
10
true
https://github.com/PKU-YuanGroup/ProLLaMA
IEEE Transactions on Artificial Intelligence
0.5207
4b3fa5ac2b12de8e3fe36b67a29a76eac458045ee52277a5a15fbff825a5860a
[ "arxiv", "semantic_scholar" ]
How Important Is Tokenization in French Medical Masked Language Models?
Subword tokenization has become the prevailing standard in the field of natural language processing (NLP) over recent years, primarily due to the widespread utilization of pre-trained language models. This shift began with Byte-Pair Encoding (BPE) and was later followed by the adoption of SentencePiece and WordPiece. W...
[ "Yanis Labrak", "Adrien Bazoge", "Beatrice Daille", "Mickael Rouvier", "Richard Dufour" ]
[ "cs.CL", "cs.AI", "cs.LG" ]
[ "Computer Science" ]
2024-02-22T00:00:00
https://arxiv.org/abs/2402.15010
https://arxiv.org/pdf/2402.15010v2
2402.15010
10.48550/arXiv.2402.15010
2
0
false
null
International Conference on Language Resources and Evaluation
0.1193
cd6a8a9ee40166a4dba02d9f168ca0a5b9b5acd51793aa42d5108a5cb53cd484
[ "arxiv", "semantic_scholar" ]
Analysing The Impact of Sequence Composition on Language Model Pre-Training
Most language model pre-training frameworks concatenate multiple documents into fixed-length sequences and use causal masking to compute the likelihood of each token given its context; this strategy is widely adopted due to its simplicity and efficiency. However, to this day, the influence of the pre-training sequence ...
[ "Yu Zhao", "Yuanbin Qu", "Konrad Staniszewski", "Szymon Tworkowski", "Wei Liu", "Piotr Miłoś", "Yuxiang Wu", "Pasquale Minervini" ]
[ "cs.CL" ]
[ "Computer Science" ]
2024-02-21T00:00:00
https://arxiv.org/abs/2402.13991
https://arxiv.org/pdf/2402.13991v1
2402.13991
10.18653/v1/2024.acl-long.427
23
2
false
null
Annual Meeting of the Association for Computational Linguistics
0.3451
4f29fe266275011a800fbb298a64913404ac6356e54a4aebabdf381b53238deb
[ "arxiv", "semantic_scholar" ]
TEXT2AFFORD: Probing Object Affordance Prediction abilities of Language Models solely from Text
We investigate the knowledge of object affordances in pre-trained language models (LMs) and pre-trained Vision-Language models (VLMs). A growing body of literature shows that PTLMs fail inconsistently and non-intuitively, demonstrating a lack of reasoning and grounding. To take a first step toward quantifying the effec...
[ "Sayantan Adak", "Daivik Agrawal", "Animesh Mukherjee", "Somak Aditya" ]
[ "cs.CL" ]
[ "Computer Science" ]
2024-02-20T00:00:00
https://arxiv.org/abs/2402.12881
https://arxiv.org/pdf/2402.12881v3
2402.12881
10.18653/v1/2024.conll-1.27
7
0
true
https://github.com/sayantan11995/Text2Afford
Conference on Computational Natural Language Learning
0.2258
97aa69029586ee3c37de4bdabc558289466e08f5b3c14f62f8e8e5e2bb8e8d51
[ "arxiv", "semantic_scholar" ]
Exploring the Frontier of Vision-Language Models: A Survey of Current Methodologies and Future Directions
The advent of Large Language Models (LLMs) has significantly reshaped the trajectory of the AI revolution. Nevertheless, these LLMs exhibit a notable limitation, as they are primarily adept at processing textual information. To address this constraint, researchers have endeavored to integrate visual capabilities with L...
[ "Akash Ghosh", "Arkadeep Acharya", "Sriparna Saha", "Vinija Jain", "Aman Chadha" ]
[ "cs.CV", "cs.AI", "cs.CL" ]
[ "Computer Science" ]
2024-02-20T00:00:00
https://arxiv.org/abs/2404.07214
https://arxiv.org/pdf/2404.07214v4
2404.07214
10.48550/arXiv.2404.07214
85
3
false
null
arXiv.org
0.4836
c2e884c616d99c0b45de7f42f49d7c491805537ba6d607e924412c2438ec1a06
[ "arxiv", "semantic_scholar" ]
Learning From Failure: Integrating Negative Examples when Fine-tuning Large Language Models as Agents
Large language models (LLMs) have achieved success in acting as agents, which interact with environments through tools such as search engines. However, LLMs are optimized for language generation instead of tool use during training or alignment, limiting their effectiveness as agents. To resolve this problem, previous w...
[ "Renxi Wang", "Haonan Li", "Xudong Han", "Yixuan Zhang", "Timothy Baldwin" ]
[ "cs.CL" ]
[ "Computer Science" ]
2024-02-18T00:00:00
https://arxiv.org/abs/2402.11651
https://arxiv.org/pdf/2402.11651v2
2402.11651
10.48550/arXiv.2402.11651
46
4
false
null
arXiv.org
0.418
3a2b4d363f14a51266e4ed10929e95c205685227469ebebdb852655f7bbbe91d
[ "arxiv", "semantic_scholar" ]
Fast Vocabulary Transfer for Language Model Compression
Real-world business applications require a trade-off between language model performance and size. We propose a new method for model compression that relies on vocabulary transfer. We evaluate the method on various vertical domains and downstream tasks. Our results indicate that vocabulary transfer can be effectively us...
[ "Leonidas Gee", "Andrea Zugarini", "Leonardo Rigutini", "Paolo Torroni" ]
[ "cs.CL", "cs.AI", "cs.LG" ]
[ "Computer Science" ]
2024-02-15T00:00:00
https://arxiv.org/abs/2402.09977
https://arxiv.org/pdf/2402.09977v1
2402.09977
10.18653/v1/2022.emnlp-industry.41
50
10
false
null
Conference on Empirical Methods in Natural Language Processing
0.5207
09101d37ca0bf2bb7fcbd8d414984aefb5842198af722f0c99dd9890c458ac97
[ "arxiv", "semantic_scholar" ]
ProtChatGPT: Towards Understanding Proteins with Large Language Models
Protein research is crucial in various fundamental disciplines, but understanding their intricate structure-function relationships remains challenging. Recent Large Language Models (LLMs) have made significant strides in comprehending task-specific knowledge, suggesting the potential for ChatGPT-like systems specialize...
[ "Chao Wang", "Hehe Fan", "Ruijie Quan", "Yi Yang" ]
[ "cs.CE", "cs.AI", "q-bio.BM" ]
[ "Computer Science", "Biology" ]
2024-02-15T00:00:00
https://arxiv.org/abs/2402.09649
https://arxiv.org/pdf/2402.09649v2
2402.09649
10.48550/arXiv.2402.09649
27
1
false
null
arXiv.org
0.3618
af4a70d73d6e73598363457efb55c1a5c0a988b1c5b1c542c05311e5cad1a24a
[ "arxiv", "semantic_scholar" ]
Structured Language Generation Model: Loss Calibration and Formatted Decoding for Robust Structure Prediction and Knowledge Retrieval
Modern generative pre-trained language models excel at open-ended text generation, yet continue to underperform on structure-related tasks such as NER, relation extraction, and semantic role labeling, especially when compared to encoder-only models of similar sizes. While this gap has been attributed to limited structu...
[ "Minho Lee", "Junghyun Min", "Yerang Kim", "Woochul Lee", "Yeonsoo Lee" ]
[ "cs.CL" ]
[ "Computer Science" ]
2024-02-14T00:00:00
https://arxiv.org/abs/2402.08971
https://arxiv.org/pdf/2402.08971v3
2402.08971
null
2
0
false
null
null
0.1193
0be0aad374a66a9f6877747bee25bb60c6bb085669c69dbea7c4edb89a9bdeac
[ "arxiv", "semantic_scholar" ]
PSC-CPI: Multi-Scale Protein Sequence-Structure Contrasting for Efficient and Generalizable Compound-Protein Interaction Prediction
Compound-Protein Interaction (CPI) prediction aims to predict the pattern and strength of compound-protein interactions for rational drug discovery. Existing deep learning-based methods utilize only the single modality of protein sequences or structures and lack the co-modeling of the joint distribution of the two moda...
[ "Lirong Wu", "Yufei Huang", "Cheng Tan", "Zhangyang Gao", "Bozhen Hu", "Haitao Lin", "Zicheng Liu", "Stan Z. Li" ]
[ "q-bio.BM", "cs.AI", "cs.LG" ]
[ "Computer Science", "Biology" ]
2024-02-13T00:00:00
https://arxiv.org/abs/2402.08198
https://arxiv.org/pdf/2402.08198v1
2402.08198
10.48550/arXiv.2402.08198
22
1
false
null
AAAI Conference on Artificial Intelligence
0.3404
6152b478148e883b6b67f2f7ce39b9dcf85e58a28cc4a0d08f29ba870cb5498e
[ "arxiv", "semantic_scholar" ]
Do Membership Inference Attacks Work on Large Language Models?
Membership inference attacks (MIAs) attempt to predict whether a particular datapoint is a member of a target model's training data. Despite extensive research on traditional machine learning models, there has been limited work studying MIA on the pre-training data of large language models (LLMs). We perform a large-sc...
[ "Michael Duan", "Anshuman Suri", "Niloofar Mireshghallah", "Sewon Min", "Weijia Shi", "Luke Zettlemoyer", "Yulia Tsvetkov", "Yejin Choi", "David Evans", "Hannaneh Hajishirzi" ]
[ "cs.CL" ]
[ "Computer Science" ]
2024-02-12T00:00:00
https://arxiv.org/abs/2402.07841
https://arxiv.org/pdf/2402.07841v2
2402.07841
null
217
34
false
null
arXiv.org
0.772
a4d05d6d7fa04c8f551b6e7015b8894144a07e894a3d4fa58469030ed72d5354
[ "arxiv", "semantic_scholar" ]
X-LoRA: Mixture of Low-Rank Adapter Experts, a Flexible Framework for Large Language Models with Applications in Protein Mechanics and Molecular Design
We report a mixture of expert strategy to create fine-tuned large language models using a deep layer-wise token-level approach based on low-rank adaptation (LoRA). Starting with a set of pre-trained LoRA adapters, our gating strategy uses the hidden states to dynamically mix adapted layers, allowing the resulting X-LoR...
[ "Eric L. Buehler", "Markus J. Buehler" ]
[ "cond-mat.soft", "cond-mat.dis-nn", "cs.AI", "cs.CL", "cs.LG", "q-bio.QM" ]
[ "Computer Science", "Physics", "Biology" ]
2024-02-11T00:00:00
https://arxiv.org/abs/2402.07148
https://arxiv.org/pdf/2402.07148v2
2402.07148
10.48550/arXiv.2402.07148
62
1
false
null
APL Machine Learning
0.4498
8567ed94c811fb0acafc4bf47e5ad5a9ea8e1da988728f978eb076b99d1de874
[ "arxiv", "semantic_scholar" ]
Structure-Informed Protein Language Model
Protein language models are a powerful tool for learning protein representations through pre-training on vast protein sequence datasets. However, traditional protein language models lack explicit structural supervision, despite its relevance to protein function. To address this issue, we introduce the integration of re...
[ "Zuobai Zhang", "Jiarui Lu", "Vijil Chenthamarakshan", "Aurélie Lozano", "Payel Das", "Jian Tang" ]
[ "q-bio.BM", "cs.LG" ]
[ "Computer Science", "Biology" ]
2024-02-07T00:00:00
https://arxiv.org/abs/2402.05856
https://arxiv.org/pdf/2402.05856v1
2402.05856
10.48550/arXiv.2402.05856
15
1
true
https://github.com/DeepGraphLearning/esm-s
arXiv.org
0.301
1b5f3e7b743400689022dd8e7a65b34aee90f3aa1c54b82344006df5df4ef40e
[ "arxiv", "semantic_scholar" ]
AlphaFold Meets Flow Matching for Generating Protein Ensembles
The biological functions of proteins often depend on dynamic structural ensembles. In this work, we develop a flow-based generative modeling approach for learning and sampling the conformational landscapes of proteins. We repurpose highly accurate single-state predictors such as AlphaFold and ESMFold and fine-tune them...
[ "Bowen Jing", "Bonnie Berger", "Tommi Jaakkola" ]
[ "q-bio.BM", "cs.LG" ]
[ "Computer Science", "Biology" ]
2024-02-07T00:00:00
https://arxiv.org/abs/2402.04845
https://arxiv.org/pdf/2402.04845v2
2402.04845
10.48550/arXiv.2402.04845
248
29
true
https://github.com/bjing2016/alphaflow
International Conference on Machine Learning
0.7386
b81cd57a435f3ce758b52e1895bf8bf730a90b96d5d694c2442416da4e683c36
[ "arxiv", "semantic_scholar" ]
Learning immune receptor representations with protein language models
Protein language models (PLMs) learn contextual representations from protein sequences and are profoundly impacting various scientific disciplines spanning protein design, drug discovery, and structural predictions. One particular research area where PLMs have gained considerable attention is adaptive immune receptors,...
[ "Andreas Dounas", "Tudor-Stefan Cotet", "Alexander Yermanos" ]
[ "q-bio.QM" ]
[ "Biology" ]
2024-02-06T00:00:00
https://arxiv.org/abs/2402.03823
https://arxiv.org/pdf/2402.03823v1
2402.03823
null
6
1
false
null
null
0.2113
fb085fe9398a841835cd9372771b9700e807793afcd55db9c85ad2ce34045fd2
[ "arxiv", "semantic_scholar" ]
Detecting Mode Collapse in Language Models via Narration
No two authors write alike. Personal flourishes invoked in written narratives, from lexicon to rhetorical devices, imply a particular author--what literary theorists label the implied or virtual author; distinct from the real author or narrator of a text. Early large language models trained on unfiltered training sets ...
[ "Sil Hamilton" ]
[ "cs.CL", "cs.AI" ]
[ "Computer Science" ]
2024-02-06T00:00:00
https://arxiv.org/abs/2402.04477
https://arxiv.org/pdf/2402.04477v1
2402.04477
10.48550/arXiv.2402.04477
23
2
false
null
https://aclanthology.org/2024.scalellm-1.5/
0.3451
fd4cfe0bd527b1bd43e1d6ea9570458bf2d506069cc816171da590de9bfcc101
[ "arxiv", "semantic_scholar" ]
idMotif: An Interactive Motif Identification in Protein Sequences
This article introduces idMotif, a visual analytics framework designed to aid domain experts in the identification of motifs within protein sequences. Motifs, short sequences of amino acids, are critical for understanding the distinct functions of proteins. Identifying these motifs is pivotal for predicting diseases or...
[ "Ji Hwan Park", "Vikash Prasad", "Sydney Newsom", "Fares Najar", "Rakhi Rajan" ]
[ "q-bio.QM", "cs.GR", "cs.HC", "cs.LG" ]
[ "Computer Science", "Medicine", "Biology" ]
2024-02-04T00:00:00
https://arxiv.org/abs/2402.05953
https://arxiv.org/pdf/2402.05953v1
2402.05953
10.1109/MCG.2023.3345742
1
0
false
null
IEEE Computer Graphics and Applications
0.0753
2f8b82da1e82d858fbc26124887f99cefef76b9f162500cdc450cc0476227f11
[ "arxiv", "semantic_scholar" ]
Enhancing the efficiency of protein language models with minimal wet-lab data through few-shot learning
Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Recently, due to their capacity and representation ability, pre-trained protein language models have achieved state-of-the-art performance in predicting protein fitness without experimental data. However, their prediction...
[ "Ziyi Zhou", "Liang Zhang", "Yuanxi Yu", "Mingchen Li", "Liang Hong", "Pan Tan" ]
[ "q-bio.BM" ]
[ "Biology" ]
2024-02-03T00:00:00
https://arxiv.org/abs/2402.02004
https://arxiv.org/pdf/2402.02004v1
2402.02004
null
29
0
false
null
null
0.3693
3d9e936cd078517bd1fe6d4648569f3659b30448339c583e849328caced87184
[ "arxiv", "semantic_scholar" ]
ProtAgents: Protein discovery via large language model multi-agent collaborations combining physics and machine learning
Designing de novo proteins beyond those found in nature holds significant promise for advancements in both scientific and engineering applications. Current methodologies for protein design often rely on AI-based models, such as surrogate models that address end-to-end problems by linking protein structure to material p...
[ "A. Ghafarollahi", "M. J. Buehler" ]
[ "cond-mat.soft", "cs.AI", "cs.CL", "q-bio.BM" ]
[ "Physics", "Computer Science", "Biology", "Medicine" ]
2024-01-27T00:00:00
https://arxiv.org/abs/2402.04268
https://arxiv.org/pdf/2402.04268v1
2402.04268
10.48550/arXiv.2402.04268
95
3
false
null
Digital Discovery
0.4956
c918f07b1044ab6165a8297f19832449868e3fdceabfe75befb2e433ed4ed2ec
[ "arxiv", "semantic_scholar" ]
Endowing Protein Language Models with Structural Knowledge
Understanding the relationships between protein sequence, structure and function is a long-standing biological challenge with manifold implications from drug design to our understanding of evolution. Recently, protein language models have emerged as the preferred method for this challenge, thanks to their ability to ha...
[ "Dexiong Chen", "Philip Hartout", "Paolo Pellizzoni", "Carlos Oliver", "Karsten Borgwardt" ]
[ "q-bio.QM", "cs.LG", "q-bio.BM" ]
[ "Computer Science", "Biology" ]
2024-01-26T00:00:00
https://arxiv.org/abs/2401.14819
https://arxiv.org/pdf/2401.14819v1
2401.14819
10.48550/arXiv.2401.14819
22
1
true
https://github.com/BorgwardtLab/PST
arXiv.org
0.3404
430fe979c85df95218bd9cc2f622d91b779bb0843c78d836fab1ec81156f253e
[ "arxiv", "semantic_scholar" ]
Evolutionary Computation in the Era of Large Language Model: Survey and Roadmap
Large language models (LLMs) have not only revolutionized natural language processing but also extended their prowess to various domains, marking a significant stride towards artificial general intelligence. The interplay between LLMs and evolutionary algorithms (EAs), despite differing in objectives and methodologies,...
[ "Xingyu Wu", "Sheng-hao Wu", "Jibin Wu", "Liang Feng", "Kay Chen Tan" ]
[ "cs.NE", "cs.AI", "cs.CL" ]
[ "Computer Science" ]
2024-01-18T00:00:00
https://arxiv.org/abs/2401.10034
https://arxiv.org/pdf/2401.10034v3
2401.10034
10.1109/TEVC.2024.3506731
181
4
true
https://github.com/wuxingyu-ai/LLM4EC
IEEE Transactions on Evolutionary Computation
0.565
41713d942bb1746a0ee489db986fbd387a9cc8313e22da375315c07efebfd623
[ "arxiv", "semantic_scholar" ]
Part-of-Speech Tagger for Bodo Language using Deep Learning approach
Language Processing systems such as Part-of-speech tagging, Named entity recognition, Machine translation, Speech recognition, and Language modeling (LM) are well-studied in high-resource languages. Nevertheless, research on these systems for several low-resource languages, including Bodo, Mizo, Nagamese, and others, i...
[ "Dhrubajyoti Pathak", "Sanjib Narzary", "Sukumar Nandi", "Bidisha Som" ]
[ "cs.CL", "cs.AI", "cs.LG" ]
[ "Computer Science" ]
2024-01-06T00:00:00
https://arxiv.org/abs/2401.03175
https://arxiv.org/pdf/2401.03175v1
2401.03175
10.1017/nlp.2024.15
7
0
false
null
Natural Language Processing
0.2258
2fa521d10b2118188e460da13c2744ad40d4f1140016c5b8f2c3fe00778a9c71
[ "arxiv", "semantic_scholar" ]
ACP-ESM: A novel framework for classification of anticancer peptides using protein-oriented transformer approach
Anticancer peptides (ACPs) are a class of molecules that have gained significant attention in the field of cancer research and therapy. ACPs are short chains of amino acids, the building blocks of proteins, and they possess the ability to selectively target and kill cancer cells. One of the key advantages of ACPs is th...
[ "Zeynep Hilal Kilimci", "Mustafa Yalcin" ]
[ "q-bio.BM", "cs.AI", "cs.CE", "cs.LG" ]
[ "Medicine", "Computer Science", "Biology" ]
2024-01-04T00:00:00
https://arxiv.org/abs/2401.02124
https://arxiv.org/pdf/2401.02124v1
2401.02124
10.48550/arXiv.2401.02124
14
0
false
null
null
0.294
157542eac9f9fb89d45719a0a43aec218affed145b09d578667be3383fcba9ef
[ "arxiv", "semantic_scholar" ]
Identification of Knowledge Neurons in Protein Language Models
Neural language models have become powerful tools for learning complex representations of entities in natural language processing tasks. However, their interpretability remains a significant challenge, particularly in domains like computational biology where trust in model predictions is crucial. In this work, we aim t...
[ "Divya Nori", "Shivali Singireddy", "Marina Ten Have" ]
[ "cs.LG", "cs.AI", "cs.CL", "q-bio.BM" ]
[ "Computer Science", "Biology" ]
2023-12-17T00:00:00
https://arxiv.org/abs/2312.10770
https://arxiv.org/pdf/2312.10770v1
2312.10770
10.48550/arXiv.2312.10770
4
0
false
null
arXiv.org
0.1747
fad3b06eab1c317aa9fda2813083959535c503618961a660e23072540982672d
[ "arxiv", "semantic_scholar" ]
Demystifying Instruction Mixing for Fine-tuning Large Language Models
Instruction tuning significantly enhances the performance of large language models (LLMs) across various tasks. However, the procedure to optimizing the mixing of instruction datasets for LLM fine-tuning is still poorly understood. This study categorizes instructions into three primary types: NLP downstream tasks, codi...
[ "Renxi Wang", "Haonan Li", "Minghao Wu", "Yuxia Wang", "Xudong Han", "Chiyu Zhang", "Timothy Baldwin" ]
[ "cs.CL", "cs.AI" ]
[ "Computer Science" ]
2023-12-17T00:00:00
https://arxiv.org/abs/2312.10793
https://arxiv.org/pdf/2312.10793v3
2312.10793
10.18653/v1/2024.acl-srw.15
8
0
false
null
Annual Meeting of the Association for Computational Linguistics
0.2386
9438d738250c9b7e92a49cf30c6731c4c24d0dc520f3a0d6c8957ac9a4b41d70
[ "arxiv", "semantic_scholar" ]
Beneath the Surface: Unveiling Harmful Memes with Multimodal Reasoning Distilled from Large Language Models
The age of social media is rife with memes. Understanding and detecting harmful memes pose a significant challenge due to their implicit meaning that is not explicitly conveyed through the surface text and image. However, existing harmful meme detection approaches only recognize superficial harm-indicative signals in a...
[ "Hongzhan Lin", "Ziyang Luo", "Jing Ma", "Long Chen" ]
[ "cs.CL" ]
[ "Computer Science" ]
2023-12-09T00:00:00
https://arxiv.org/abs/2312.05434
https://arxiv.org/pdf/2312.05434v1
2312.05434
10.18653/v1/2023.findings-emnlp.611
27
2
false
null
Conference on Empirical Methods in Natural Language Processing
0.3618
830d7d6cce586c2b9f8f0a9cf11b2d2e937491630cdad176be024e936edc6f37
[ "arxiv", "semantic_scholar" ]
Efficiently Predicting Protein Stability Changes Upon Single-point Mutation with Large Language Models
Predicting protein stability changes induced by single-point mutations has been a persistent challenge over the years, attracting immense interest from numerous researchers. The ability to precisely predict protein thermostability is pivotal for various subfields and applications in biochemistry, including drug develop...
[ "Yijie Zhang", "Zhangyang Gao", "Cheng Tan", "Stan Z. Li" ]
[ "q-bio.BM", "cs.AI" ]
[ "Biology", "Computer Science" ]
2023-12-07T00:00:00
https://arxiv.org/abs/2312.04019
https://arxiv.org/pdf/2312.04019v1
2312.04019
10.48550/arXiv.2312.04019
3
0
false
null
arXiv.org
0.1505
4f084ea725e9aaa737730044e57b254527a6592d2a675a7049cd6043006f7198
[ "arxiv", "semantic_scholar" ]
Using a Large Language Model to generate a Design Structure Matrix
The Design Structure Matrix (DSM) is an established method used in dependency modelling, especially in the design of complex engineering systems. The generation of DSM is traditionally carried out through manual means and can involve interviewing experts to elicit critical system elements and the relationships between ...
[ "Edwin C. Y. Koh" ]
[ "cs.AI", "cs.CL" ]
[ "Computer Science" ]
2023-12-07T00:00:00
https://arxiv.org/abs/2312.04134
https://arxiv.org/pdf/2312.04134v1
2312.04134
10.1016/j.nlp.2024.100103
5
0
false
null
Natural Language Processing Journal
0.1945
2792a97a581ecad2d219f85cfb3cc2d13788ec28cf60f8b9723d84f3937bd38a
[ "arxiv", "semantic_scholar" ]
Protein Language Model-Powered 3D Ligand Binding Site Prediction from Protein Sequence
Prediction of ligand binding sites of proteins is a fundamental and important task for understanding the function of proteins and screening potential drugs. Most existing methods require experimentally determined protein holo-structures as input. However, such structures can be unavailable on novel or less-studied prot...
[ "Shuo Zhang", "Lei Xie" ]
[ "q-bio.QM", "cs.CL", "cs.LG" ]
[ "Biology", "Computer Science" ]
2023-12-05T00:00:00
https://arxiv.org/abs/2312.03016
https://arxiv.org/pdf/2312.03016v1
2312.03016
10.48550/arXiv.2312.03016
10
1
false
null
arXiv.org
0.2603
93ba3aa005e82c440388e61de11cadb1e28c33bad7c9da202fe42cb094499353
[ "arxiv", "semantic_scholar" ]
ESM-NBR: fast and accurate nucleic acid-binding residue prediction via protein language model feature representation and multi-task learning
Protein-nucleic acid interactions play a very important role in a variety of biological activities. Accurate identification of nucleic acid-binding residues is a critical step in understanding the interaction mechanisms. Although many computationally based methods have been developed to predict nucleic acid-binding res...
[ "Wenwu Zeng", "Dafeng Lv", "Wenjuan Liu", "Shaoliang Peng" ]
[ "q-bio.QM", "cs.LG" ]
[ "Biology", "Computer Science" ]
2023-12-01T00:00:00
https://arxiv.org/abs/2312.00842
https://arxiv.org/pdf/2312.00842v1
2312.00842
10.1109/BIBM58861.2023.10385509
8
0
true
https://github.com/wwzll123/ESM-NBR
IEEE International Conference on Bioinformatics and Biomedicine
0.2386
b41de1ba79d23211754acef5ceee8a3cc8ba11133ac1e9a857834fdafda2d3eb
[ "arxiv", "semantic_scholar" ]
A perspective on protein structure prediction using quantum computers
Despite the recent advancements by deep learning methods such as AlphaFold2, \textit{in silico} protein structure prediction remains a challenging problem in biomedical research. With the rapid evolution of quantum computing, it is natural to ask whether quantum computers can offer some meaningful benefits for approach...
[ "Hakan Doga", "Bryan Raubenolt", "Fabio Cumbo", "Jayadev Joshi", "Frank P. DiFilippo", "Jun Qin", "Daniel Blankenberg", "Omar Shehab" ]
[ "quant-ph" ]
[ "Physics", "Medicine" ]
2023-12-01T00:00:00
https://arxiv.org/abs/2312.00875
https://arxiv.org/pdf/2312.00875v1
2312.00875
10.1021/acs.jctc.4c00067
50
1
false
null
Journal of Chemical Theory and Computation
0.4269
ecc7d6bb5abf282df6a48a895466f03eacf25aaea8fe124a09eb8067e9ad9af1
[ "arxiv", "semantic_scholar" ]
Acoustic Prompt Tuning: Empowering Large Language Models with Audition Capabilities
The auditory system plays a substantial role in shaping the overall human perceptual experience. While prevailing large language models (LLMs) and visual language models (VLMs) have shown their promise in solving a wide variety of language and vision understanding tasks, only a few of them can be generalised to the aud...
[ "Jinhua Liang", "Xubo Liu", "Wenwu Wang", "Mark D. Plumbley", "Huy Phan", "Emmanouil Benetos" ]
[ "eess.AS" ]
[ "Engineering" ]
2023-11-30T00:00:00
https://arxiv.org/abs/2312.00249
https://arxiv.org/pdf/2312.00249v2
2312.00249
10.1109/TASLPRO.2025.3533375
24
1
true
https://github.com/JinhuaLiang/APT
IEEE Transactions on Audio, Speech, and Language Processing
0.3495
f44525bd159e0fb1c03ffe0c5b1d2d856e535635fb152a020c8a95121b5e301f
[ "arxiv", "semantic_scholar" ]
When a Language Question Is at Stake. A Revisited Approach to Label Sensitive Content
Many under-resourced languages require high-quality datasets for specific tasks such as offensive language detection, disinformation, or misinformation identification. However, the intricacies of the content may have a detrimental effect on the annotators. The article aims to revisit an approach of pseudo-labeling sens...
[ "Stetsenko Daria" ]
[ "cs.CL" ]
[ "Computer Science" ]
2023-11-17T00:00:00
https://arxiv.org/abs/2311.10514
https://arxiv.org/pdf/2311.10514v1
2311.10514
10.48550/arXiv.2311.10514
2
0
false
null
arXiv.org
0.1193
cd67b4d29cbff9423c4daa1e0bd25558dcb9305aa7c799bd807e62a6ac03bc79
[ "arxiv", "semantic_scholar" ]
Efficiently Adapting Pretrained Language Models To New Languages
Recent large language models (LLM) exhibit sub-optimal performance on low-resource languages, as the training data of these models is usually dominated by English and other high-resource languages. Furthermore, it is challenging to train models for low-resource languages, especially from scratch, due to a lack of high ...
[ "Zoltan Csaki", "Pian Pawakapan", "Urmish Thakker", "Qiantong Xu" ]
[ "cs.CL", "cs.AI", "cs.LG" ]
[ "Computer Science" ]
2023-11-09T00:00:00
https://arxiv.org/abs/2311.05741
https://arxiv.org/pdf/2311.05741v2
2311.05741
10.48550/arXiv.2311.05741
33
4
true
null
arXiv.org
0.3829
9e8ccae539771af72541e502e79594757be3df8ab5317589d61ca0c7f813d676
[ "arxiv", "semantic_scholar" ]
Impact of the Ce $4f$ states in the electronic structure of the intermediate-valence superconductor CeIr$_3$
The electronic structure of the $f$-based superconductor $\mathrm{CeIr_3}$ was studied by photoelectron spectroscopy. The energy distribution of the $\mathrm{Ce}~4f$ states were revealed by the $\mathrm{Ce}~3d-4f$ resonant photoelectron spectroscopy. The $\mathrm{Ce}~4f$ states were mostly distributed in the vicinity o...
[ "Shin-ichi Fujimori", "Ikuto Kawasaki", "Yukiharu Takeda", "Hiroshi Yamagami", "Norimasa Sasabe", "Yoshiki J. Sato", "Ai Nakamura", "Yusei Shimizu", "Arvind Maurya", "Yoshiya Homma", "Dexin Li", "Fuminori Honda", "Dai Aoki" ]
[ "cond-mat.str-el", "cond-mat.supr-con" ]
[ "Physics" ]
2023-11-07T00:00:00
https://arxiv.org/abs/2311.03640
https://arxiv.org/pdf/2311.03640v1
2311.03640
10.1088/2516-1075/ad0a3d
0
0
false
null
Electronic Structure
0
202b5db5492de11698d8518a7534bc87276f14ec3f24b48215395d1c9edb48ce
[ "arxiv", "semantic_scholar" ]
Can Language Models Be Tricked by Language Illusions? Easier with Syntax, Harder with Semantics
Language models (LMs) have been argued to overlap substantially with human beings in grammaticality judgment tasks. But when humans systematically make errors in language processing, should we expect LMs to behave like cognitive models of language and mimic human behavior? We answer this question by investigating LMs' ...
[ "Yuhan Zhang", "Edward Gibson", "Forrest Davis" ]
[ "cs.CL" ]
[ "Computer Science" ]
2023-11-02T00:00:00
https://arxiv.org/abs/2311.01386
https://arxiv.org/pdf/2311.01386v2
2311.01386
10.18653/v1/2023.conll-1.1
8
1
false
null
Conference on Computational Natural Language Learning
0.2386
e2fbc9168d24e9c011e6ed8f23d41ac3dc7fe947b022b22ba95e7d317447bfa8
[ "arxiv", "semantic_scholar" ]
Exploring Post-Training Quantization of Protein Language Models
Recent advancements in unsupervised protein language models (ProteinLMs), like ESM-1b and ESM-2, have shown promise in different protein prediction tasks. However, these models face challenges due to their high computational demands, significant memory needs, and latency, restricting their usage on devices with limited...
[ "Shuang Peng", "Fei Yang", "Ning Sun", "Sheng Chen", "Yanfeng Jiang", "Aimin Pan" ]
[ "cs.LG", "cs.AI", "q-bio.QM" ]
[ "Computer Science", "Biology" ]
2023-10-30T00:00:00
https://arxiv.org/abs/2310.19624
https://arxiv.org/pdf/2310.19624v1
2310.19624
10.1109/BIBM58861.2023.10385775
0
0
false
null
IEEE International Conference on Bioinformatics and Biomedicine
0
634c2cf0178fbc4edabe9241f2b824bf01875a929aeb821b964e6509992cfaf3
[ "arxiv", "semantic_scholar" ]
GPCR-BERT: Interpreting Sequential Design of G Protein Coupled Receptors Using Protein Language Models
With the rise of Transformers and Large Language Models (LLMs) in Chemistry and Biology, new avenues for the design and understanding of therapeutics have opened up to the scientific community. Protein sequences can be modeled as language and can take advantage of recent advances in LLMs, specifically with the abundanc...
[ "Seongwon Kim", "Parisa Mollaei", "Akshay Antony", "Rishikesh Magar", "Amir Barati Farimani" ]
[ "cs.LG", "q-bio.BM" ]
[ "Computer Science", "Biology", "Medicine" ]
2023-10-30T00:00:00
https://arxiv.org/abs/2310.19915
https://arxiv.org/pdf/2310.19915v1
2310.19915
10.1021/acs.jcim.3c01706
17
0
false
null
Journal of Chemical Information and Modeling
0.3138
06df6b82b7242860ccc174055d0dc1d0bd831a9a619d6d207ba5a3453961ea83
[ "arxiv", "semantic_scholar" ]
Large Language Models and Multimodal Retrieval for Visual Word Sense Disambiguation
Visual Word Sense Disambiguation (VWSD) is a novel challenging task with the goal of retrieving an image among a set of candidates, which better represents the meaning of an ambiguous word within a given context. In this paper, we make a substantial step towards unveiling this interesting task by applying a varying set...
[ "Anastasia Kritharoula", "Maria Lymperaiou", "Giorgos Stamou" ]
[ "cs.CL" ]
[ "Computer Science" ]
2023-10-21T00:00:00
https://arxiv.org/abs/2310.14025
https://arxiv.org/pdf/2310.14025v1
2310.14025
10.18653/v1/2023.emnlp-main.807
10
0
false
null
Conference on Empirical Methods in Natural Language Processing
0.2603
c3b6fa685318d64bd0e2bc2f7af01c5b37567e5d261138e9c1c9961420714cfb
[ "arxiv", "semantic_scholar" ]
ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a protein language diffusion model
Through evolution, nature has presented a set of remarkable protein materials, including elastins, silks, keratins and collagens with superior mechanical performances that play crucial roles in mechanobiology. However, going beyond natural designs to discover proteins that meet specified mechanical properties remains c...
[ "Bo Ni", "David L. Kaplan", "Markus J. Buehler" ]
[ "cond-mat.mtrl-sci", "cond-mat.mes-hall", "cs.CL", "cs.LG", "q-bio.BM" ]
[ "Computer Science", "Physics", "Biology", "Medicine" ]
2023-10-16T00:00:00
https://arxiv.org/abs/2310.10605
https://arxiv.org/pdf/2310.10605v3
2310.10605
10.48550/arXiv.2310.10605
5
0
false
null
arXiv.org
0.1945
89093eeb1c7ae6ee601b9244a24075254cf96f8a5d3a70ccfdc737cd8cd08467
[ "arxiv", "semantic_scholar" ]
Joint Music and Language Attention Models for Zero-shot Music Tagging
Music tagging is a task to predict the tags of music recordings. However, previous music tagging research primarily focuses on close-set music tagging tasks which can not be generalized to new tags. In this work, we propose a zero-shot music tagging system modeled by a joint music and language attention (JMLA) model to...
[ "Xingjian Du", "Zhesong Yu", "Jiaju Lin", "Bilei Zhu", "Qiuqiang Kong" ]
[ "cs.SD", "cs.CL", "eess.AS" ]
[ "Computer Science", "Engineering" ]
2023-10-16T00:00:00
https://arxiv.org/abs/2310.10159
https://arxiv.org/pdf/2310.10159v1
2310.10159
10.1109/ICASSP48485.2024.10447760
15
2
false
null
IEEE International Conference on Acoustics, Speech, and Signal Processing
0.301
dcab335dc09cd6f12d3c1fd70d5d10ae35fe37845b8b858c30762f26f961bb00
[ "arxiv", "semantic_scholar" ]
Protein 3D Graph Structure Learning for Robust Structure-based Protein Property Prediction
Protein structure-based property prediction has emerged as a promising approach for various biological tasks, such as protein function prediction and sub-cellular location estimation. The existing methods highly rely on experimental protein structure data and fail in scenarios where these data are unavailable. Predicte...
[ "Yufei Huang", "Siyuan Li", "Jin Su", "Lirong Wu", "Odin Zhang", "Haitao Lin", "Jingqi Qi", "Zihan Liu", "Zhangyang Gao", "Yuyang Liu", "Jiangbin Zheng", "Stan. ZQ. Li" ]
[ "cs.LG", "cs.AI", "q-bio.QM" ]
[ "Computer Science", "Biology" ]
2023-10-14T00:00:00
https://arxiv.org/abs/2310.11466
https://arxiv.org/pdf/2310.11466v2
2310.11466
10.48550/arXiv.2310.11466
18
0
false
null
AAAI Conference on Artificial Intelligence
0.3197
361b7e3af0b692812d098f5ae248a268fe6c998a9e7b05bfdea77af1c241e0aa
[ "arxiv", "semantic_scholar" ]
Humans and language models diverge when predicting repeating text
Language models that are trained on the next-word prediction task have been shown to accurately model human behavior in word prediction and reading speed. In contrast with these findings, we present a scenario in which the performance of humans and LMs diverges. We collected a dataset of human next-word predictions for...
[ "Aditya R. Vaidya", "Javier Turek", "Alexander G. Huth" ]
[ "cs.CL" ]
[ "Computer Science" ]
2023-10-10T00:00:00
https://arxiv.org/abs/2310.06408
https://arxiv.org/pdf/2310.06408v2
2310.06408
10.48550/arXiv.2310.06408
15
1
true
https://github.com/HuthLab/lm-repeating-text
Conference on Computational Natural Language Learning
0.301
f31bb63467688df60672e649c8fb9063df8069b9bc9c5f6d833b2550b5b47fba
[ "arxiv", "semantic_scholar" ]
Growing ecosystem of deep learning methods for modeling protein$\unicode{x2013}$protein interactions
Numerous cellular functions rely on protein$\unicode{x2013}$protein interactions. Efforts to comprehensively characterize them remain challenged however by the diversity of molecular recognition mechanisms employed within the proteome. Deep learning has emerged as a promising approach for tackling this problem by explo...
[ "Julia R. Rogers", "Gergő Nikolényi", "Mohammed AlQuraishi" ]
[ "q-bio.BM", "cs.LG" ]
[ "Biology", "Computer Science", "Medicine" ]
2023-10-10T00:00:00
https://arxiv.org/abs/2310.06725
https://arxiv.org/pdf/2310.06725v2
2310.06725
10.48550/arXiv.2310.06725
9
0
false
null
null
0.25
11968fb1f30519423fc8cd131f2541da67034c72ffcbd30765eaa38747acda38
[ "arxiv", "semantic_scholar" ]
VQPL: Vector Quantized Protein Language
Is there a foreign language describing protein sequences and structures simultaneously? Protein structures, represented by continuous 3D points, have long posed a challenge due to the contrasting modeling paradigms of discrete sequences. To represent protein sequence-structure as discrete symbols, we propose a VQProtei...
[ "Zhangyang Gao", "Cheng Tan", "Stan Z. Li" ]
[ "cs.CE" ]
[ "Computer Science" ]
2023-10-08T00:00:00
https://arxiv.org/abs/2310.04985
https://arxiv.org/pdf/2310.04985v1
2310.04985
10.48550/arXiv.2310.04985
7
0
false
null
arXiv.org
0.2258
6c4f17468cc3ae2785cd6725e7a910eaa7007408737bdc8613171652308449a8
[ "arxiv", "semantic_scholar" ]
PGraphDTA: Improving Drug Target Interaction Prediction using Protein Language Models and Contact Maps
Developing and discovering new drugs is a complex and resource-intensive endeavor that often involves substantial costs, time investment, and safety concerns. A key aspect of drug discovery involves identifying novel drug-target (DT) interactions. Existing computational methods for predicting DT interactions have prima...
[ "Rakesh Bal", "Yijia Xiao", "Wei Wang" ]
[ "cs.LG", "q-bio.QM" ]
[ "Computer Science", "Biology" ]
2023-10-06T00:00:00
https://arxiv.org/abs/2310.04017
https://arxiv.org/pdf/2310.04017v3
2310.04017
10.48550/arXiv.2310.04017
6
0
true
https://github.com/Yijia-Xiao/PgraphDTA/
arXiv.org
0.2113
9f71c553ac494a20e1db34707694b9703cf41a23d0caddf2dbf6621c16f4c76c
[ "arxiv", "semantic_scholar" ]
InstructProtein: Aligning Human and Protein Language via Knowledge Instruction
Large Language Models (LLMs) have revolutionized the field of natural language processing, but they fall short in comprehending biological sequences such as proteins. To address this challenge, we propose InstructProtein, an innovative LLM that possesses bidirectional generation capabilities in both human and protein l...
[ "Zeyuan Wang", "Qiang Zhang", "Keyan Ding", "Ming Qin", "Xiang Zhuang", "Xiaotong Li", "Huajun Chen" ]
[ "q-bio.BM", "cs.CL" ]
[ "Computer Science", "Biology" ]
2023-10-05T00:00:00
https://arxiv.org/abs/2310.03269
https://arxiv.org/pdf/2310.03269v1
2310.03269
10.48550/arXiv.2310.03269
40
1
false
null
Annual Meeting of the Association for Computational Linguistics
0.4032
cfa49c929a45cf3d611e30bbaa3596c403ce7fe03f7ea34732e0a8cb8e9e2c3b
[ "arxiv", "semantic_scholar" ]
CrysFormer: Protein Structure Prediction via 3d Patterson Maps and Partial Structure Attention
Determining the structure of a protein has been a decades-long open question. A protein's three-dimensional structure often poses nontrivial computation costs, when classical simulation algorithms are utilized. Advances in the transformer neural network architecture -- such as AlphaFold2 -- achieve significant improvem...
[ "Chen Dun", "Qiutai Pan", "Shikai Jin", "Ria Stevens", "Mitchell D. Miller", "George N. Phillips,", "Anastasios Kyrillidis" ]
[ "cs.LG" ]
[ "Computer Science" ]
2023-10-05T00:00:00
https://arxiv.org/abs/2310.03899
https://arxiv.org/pdf/2310.03899v1
2310.03899
10.48550/arXiv.2310.03899
2
0
false
null
arXiv.org
0.1193
3ae1a41de90b8fd376c39a07f3979c4f1402250234232ce12ad8a5dab07ad991
[ "arxiv", "semantic_scholar" ]
All Languages Matter: On the Multilingual Safety of Large Language Models
Safety lies at the core of developing and deploying large language models (LLMs). However, previous safety benchmarks only concern the safety in one language, e.g. the majority language in the pretraining data such as English. In this work, we build the first multilingual safety benchmark for LLMs, XSafety, in response...
[ "Wenxuan Wang", "Zhaopeng Tu", "Chang Chen", "Youliang Yuan", "Jen-tse Huang", "Wenxiang Jiao", "Michael R. Lyu" ]
[ "cs.CL", "cs.AI" ]
[ "Computer Science" ]
2023-10-02T00:00:00
https://arxiv.org/abs/2310.00905
https://arxiv.org/pdf/2310.00905v2
2310.00905
10.48550/arXiv.2310.00905
50
5
true
https://github.com/Jarviswang94/Multilingual_safety_benchmark
arXiv.org
0.4269
65372dce4caf433ef4defe378813c06c16895b8a33e6bb0ad84a3d05a759c0b7
[ "arxiv", "semantic_scholar" ]
PB-LLM: Partially Binarized Large Language Models
This paper explores network binarization, a radical form of quantization, compressing model weights to a single bit, specifically for Large Language Models (LLMs) compression. Due to previous binarization methods collapsing LLMs, we propose a novel approach, Partially-Binarized LLM (PB-LLM), which can achieve extreme l...
[ "Yuzhang Shang", "Zhihang Yuan", "Qiang Wu", "Zhen Dong" ]
[ "cs.LG", "cs.AI", "cs.CL" ]
[ "Computer Science" ]
2023-09-29T00:00:00
https://arxiv.org/abs/2310.00034
https://arxiv.org/pdf/2310.00034v2
2310.00034
10.48550/arXiv.2310.00034
95
15
true
https://github.com/hahnyuan/BinaryLLM
International Conference on Learning Representations
0.6021
7230ecfbb022cebc7c7f39de0dc235be982dbc84969c15e212e0c203da79972c
[ "arxiv", "semantic_scholar" ]
pLMFPPred: a novel approach for accurate prediction of functional peptides integrating embedding from pre-trained protein language model and imbalanced learning
Functional peptides have the potential to treat a variety of diseases. Their good therapeutic efficacy and low toxicity make them ideal therapeutic agents. Artificial intelligence-based computational strategies can help quickly identify new functional peptides from collections of protein sequences and discover their di...
[ "Zebin Ma", "Yonglin Zou", "Xiaobin Huang", "Wenjin Yan", "Hao Xu", "Jiexin Yang", "Ying Zhang", "Jinqi Huang" ]
[ "q-bio.QM", "cs.LG" ]
[ "Computer Science", "Biology" ]
2023-09-25T00:00:00
https://arxiv.org/abs/2309.14404
https://arxiv.org/pdf/2309.14404v1
2309.14404
10.48550/arXiv.2309.14404
4
0
false
null
arXiv.org
0.1747
d2dd2d2d7a18e63289156f8dcf91630610e899794fd94a3681e763db652b77af
[ "arxiv", "semantic_scholar" ]
Speaker attribution in German parliamentary debates with QLoRA-adapted large language models
The growing body of political texts opens up new opportunities for rich insights into political dynamics and ideologies but also increases the workload for manual analysis. Automated speaker attribution, which detects who said what to whom in a speech event and is closely related to semantic role labeling, is an import...
[ "Tobias Bornheim", "Niklas Grieger", "Patrick Gustav Blaneck", "Stephan Bialonski" ]
[ "cs.CL" ]
[ "Computer Science" ]
2023-09-18T00:00:00
https://arxiv.org/abs/2309.09902
https://arxiv.org/pdf/2309.09902v2
2309.09902
10.21248/jlcl.37.2024.244
2
0
false
null
Journal for Language Technology and Computational Linguistics
0.1193
1228aed58d0055d19b8c959ff70dd01706e62c39d913f12f1e0e3648a1b174a6
[ "arxiv", "semantic_scholar" ]
Jais and Jais-chat: Arabic-Centric Foundation and Instruction-Tuned Open Generative Large Language Models
We introduce Jais and Jais-chat, new state-of-the-art Arabic-centric foundation and instruction-tuned open generative large language models (LLMs). The models are based on the GPT-3 decoder-only architecture and are pretrained on a mixture of Arabic and English texts, including source code in various programming langua...
[ "Neha Sengupta", "Sunil Kumar Sahu", "Bokang Jia", "Satheesh Katipomu", "Haonan Li", "Fajri Koto", "William Marshall", "Gurpreet Gosal", "Cynthia Liu", "Zhiming Chen", "Osama Mohammed Afzal", "Samta Kamboj", "Onkar Pandit", "Rahul Pal", "Lalit Pradhan", "Zain Muhammad Mujahid", "Mass...
[ "cs.CL", "cs.AI", "cs.LG" ]
[ "Computer Science" ]
2023-08-30T00:00:00
https://arxiv.org/abs/2308.16149
https://arxiv.org/pdf/2308.16149v2
2308.16149
10.48550/arXiv.2308.16149
81
8
false
null
arXiv.org
0.4785
b4998bcc11ee75a6f15470d1055606546eff53b29cf64efe7465db3b36b9531a
[ "arxiv", "semantic_scholar" ]
Atom-by-atom protein generation and beyond with language models
Protein language models learn powerful representations directly from sequences of amino acids. However, they are constrained to generate proteins with only the set of amino acids represented in their vocabulary. In contrast, chemical language models learn atom-level representations of smaller molecules that include eve...
[ "Daniel Flam-Shepherd", "Kevin Zhu", "Alán Aspuru-Guzik" ]
[ "q-bio.BM", "cs.LG" ]
[ "Biology", "Computer Science" ]
2023-08-16T00:00:00
https://arxiv.org/abs/2308.09482
https://arxiv.org/pdf/2308.09482v1
2308.09482
10.48550/arXiv.2308.09482
3
0
false
null
arXiv.org
0.1505
165d61fc97b194ebbd7908388675d1dc3d0baa5a9a690e0a7c6d1b30fdd73a13
[ "arxiv", "semantic_scholar" ]
PEvoLM: Protein Sequence Evolutionary Information Language Model
With the exponential increase of the protein sequence databases over time, multiple-sequence alignment (MSA) methods, like PSI-BLAST, perform exhaustive and time-consuming database search to retrieve evolutionary information. The resulting position-specific scoring matrices (PSSMs) of such search engines represent a cr...
[ "Issar Arab" ]
[ "q-bio.QM", "cs.AI", "cs.LG" ]
[ "Computer Science", "Biology" ]
2023-08-16T00:00:00
https://arxiv.org/abs/2308.08578
https://arxiv.org/pdf/2308.08578v1
2308.08578
10.1109/CIBCB56990.2023.10264890
2
0
true
https://github.com/issararab/PEvoLM
IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology
0.1193
79ee2d23699659e8f8dfd6574dadff8595d3f1d64fc3fbe285910f5670d64158
[ "arxiv", "semantic_scholar" ]
Pairing interacting protein sequences using masked language modeling
Predicting which proteins interact together from amino-acid sequences is an important task. We develop a method to pair interacting protein sequences which leverages the power of protein language models trained on multiple sequence alignments, such as MSA Transformer and the EvoFormer module of AlphaFold. We formulate ...
[ "Umberto Lupo", "Damiano Sgarbossa", "Anne-Florence Bitbol" ]
[ "q-bio.BM", "cs.LG" ]
[ "Biology", "Computer Science", "Medicine" ]
2023-08-14T00:00:00
https://arxiv.org/abs/2308.07136
https://arxiv.org/pdf/2308.07136v1
2308.07136
10.1073/pnas.2311887121
25
0
false
null
bioRxiv
0.3537
21f4235e78a1427494d2450af10a9541f7dbcf443ccf0d7c985287a6da7a244b
[ "arxiv", "semantic_scholar" ]
FFF: Fragments-Guided Flexible Fitting for Building Complete Protein Structures
Cryo-electron microscopy (cryo-EM) is a technique for reconstructing the 3-dimensional (3D) structure of biomolecules (especially large protein complexes and molecular assemblies). As the resolution increases to the near-atomic scale, building protein structures de novo from cryo-EM maps becomes possible. Recently, rec...
[ "Weijie Chen", "Xinyan Wang", "Yuhang Wang" ]
[ "cs.CV", "cs.AI", "q-bio.BM", "q-bio.QM" ]
[ "Computer Science", "Biology" ]
2023-08-07T00:00:00
https://arxiv.org/abs/2308.03654
https://arxiv.org/pdf/2308.03654v1
2308.03654
10.48550/arXiv.2308.03654
0
0
false
null
arXiv.org
0
0a642f9f6efbfc66378e8980e6f5b9942da1ba7d30574abde9f6f6d54e154e66
[ "arxiv", "semantic_scholar" ]
Turkish Native Language Identification V2
This paper presents the first application of Native Language Identification (NLI) for the Turkish language. NLI is the task of automatically identifying an individual's native language (L1) based on their writing or speech in a non-native language (L2). While most NLI research has focused on L2 English, our study exten...
[ "Ahmet Yavuz Uluslu", "Gerold Schneider" ]
[ "cs.CL" ]
[ "Computer Science" ]
2023-07-27T00:00:00
https://arxiv.org/abs/2307.14850
https://arxiv.org/pdf/2307.14850v6
2307.14850
10.48550/arXiv.2307.14850
1
0
false
null
International Conference on Natural Language and Speech Processing
0.0753
4688455352a2350cb465f83bacb075b7c6a9c5b5c763f6fb34dbcf797ee6fbc5
[ "arxiv", "semantic_scholar" ]
Artificial intelligence-aided protein engineering: from topological data analysis to deep protein language models
Protein engineering is an emerging field in biotechnology that has the potential to revolutionize various areas, such as antibody design, drug discovery, food security, ecology, and more. However, the mutational space involved is too vast to be handled through experimental means alone. Leveraging accumulative protein d...
[ "Yuchi Qiu", "Guo-Wei Wei" ]
[ "q-bio.BM" ]
[ "Biology", "Medicine", "Computer Science" ]
2023-07-27T00:00:00
https://arxiv.org/abs/2307.14587
https://arxiv.org/pdf/2307.14587v1
2307.14587
10.1093/bib/bbad289
58
0
false
null
null
0.4427
94ee3581db609718775287ea45a7d4826c8c10bb02973a8493afe0f5c420d1b8
[ "arxiv", "semantic_scholar" ]
Predicting Relative Populations of Protein Conformations without a Physics Engine Using AlphaFold2
This paper presents a novel approach for predicting the relative populations of protein conformations using AlphaFold 2, an AI-powered method that has revolutionized biology by enabling the accurate prediction of protein structures. While AlphaFold 2 has shown exceptional accuracy and speed, it is designed to predict p...
[ "Gabriel Monteiro da Silva", "Jennifer Y. Cui", "David C. Dalgarno", "George P. Lisi", "Brenda M. Rubenstein" ]
[ "physics.bio-ph", "physics.chem-ph", "q-bio.BM" ]
[ "Medicine", "Physics", "Biology" ]
2023-07-26T00:00:00
https://arxiv.org/abs/2307.14470
https://arxiv.org/pdf/2307.14470v1
2307.14470
null
7
0
false
null
arXiv.org
0.2258
b3b0ab95b1e40b071c2aebb956d54dc75c2f07564e335dfa5c473c89063e313b
[ "arxiv", "semantic_scholar" ]
DeepGATGO: A Hierarchical Pretraining-Based Graph-Attention Model for Automatic Protein Function Prediction
Automatic protein function prediction (AFP) is classified as a large-scale multi-label classification problem aimed at automating protein enrichment analysis to eliminate the current reliance on labor-intensive wet-lab methods. Currently, popular methods primarily combine protein-related information and Gene Ontology (...
[ "Zihao Li", "Changkun Jiang", "Jianqiang Li" ]
[ "q-bio.QM", "cs.LG" ]
[ "Computer Science", "Biology" ]
2023-07-24T00:00:00
https://arxiv.org/abs/2307.13004
https://arxiv.org/pdf/2307.13004v1
2307.13004
10.48550/arXiv.2307.13004
8
0
false
null
arXiv.org
0.2386
f3aab11a568876ce9f21e28c56cc7d916b42434cbed2ab7b91381f260de2dd75
[ "arxiv", "semantic_scholar" ]
A Zero-shot and Few-shot Study of Instruction-Finetuned Large Language Models Applied to Clinical and Biomedical Tasks
We evaluate four state-of-the-art instruction-tuned large language models (LLMs) -- ChatGPT, Flan-T5 UL2, Tk-Instruct, and Alpaca -- on a set of 13 real-world clinical and biomedical natural language processing (NLP) tasks in English, such as named-entity recognition (NER), question-answering (QA), relation extraction ...
[ "Yanis Labrak", "Mickael Rouvier", "Richard Dufour" ]
[ "cs.CL", "cs.AI", "cs.LG" ]
[ "Computer Science" ]
2023-07-22T00:00:00
https://arxiv.org/abs/2307.12114
https://arxiv.org/pdf/2307.12114v3
2307.12114
10.48550/arXiv.2307.12114
63
5
false
null
International Conference on Language Resources and Evaluation
0.4515
e09c4ec93ac0d80e35f185502401934500279dc4fd67d293757fcca9dbd9e961
[ "arxiv", "semantic_scholar" ]
Introduction to Protein Structure
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims to give an introduction into Structural Bioinformatics, which is where the previo...
[ "Annika Jacobsen", "Erik van Dijk", "Halima Mouhib", "Bas Stringer", "Olga Ivanova", "Jose Gavaldá-Garciá", "Laura Hoekstra", "K. Anton Feenstra", "Sanne Abeln" ]
[ "q-bio.BM" ]
[ "Biology" ]
2023-07-05T00:00:00
https://arxiv.org/abs/2307.02169
https://arxiv.org/pdf/2307.02169v2
2307.02169
null
0
0
false
null
null
0
b67040e6728c6049ff97178b0f8d58e3edb2eda84dc343b385566d4b379b4c1f
[ "arxiv", "semantic_scholar" ]
Monte Carlo for Protein Structures
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims to give an introduction into Structural Bioinformatics, which is where the previo...
[ "Juami H. M. van Gils", "Maurits Dijkstra", "Halima Mouhib", "Arriën Symon Rauh", "Jocelyne Vreede", "K. Anton Feenstra", "Sanne Abeln" ]
[ "q-bio.BM" ]
[ "Biology" ]
2023-07-05T00:00:00
https://arxiv.org/abs/2307.02177
https://arxiv.org/pdf/2307.02177v2
2307.02177
null
0
0
false
null
null
0
8803f9c3723342877cd7b90741b917c21c128cf98987c89e96ad46ad28585d5b
[ "arxiv", "semantic_scholar" ]
Introduction to Protein Folding
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims to give an introduction into Structural Bioinformatics, which is where the previo...
[ "Juami H. M. van Gils", "Erik van Dijk", "Ali May", "Halima Mouhib", "Jochem Bijlard", "Annika Jacobsen", "Isabel Houtkamp", "K. Anton Feenstra", "Sanne Abeln" ]
[ "q-bio.BM" ]
[ "Biology" ]
2023-07-05T00:00:00
https://arxiv.org/abs/2307.02174
https://arxiv.org/pdf/2307.02174v2
2307.02174
null
0
0
false
null
null
0
0aa4313a168da4d589fcc11b16703456d3f1ee1dbe52620ac3b49dd933fc74ec
[ "arxiv", "semantic_scholar" ]
Thermodynamics of Protein Folding
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims to give an introduction into Structural Bioinformatics, which is where the previo...
[ "Juami H. M. van Gils", "Halima Mouhib", "Erik van Dijk", "Maurits Dijkstra", "Isabel Houtkamp", "Arthur Goetzee", "Sanne Abeln", "K. Anton Feenstra" ]
[ "q-bio.BM" ]
[ "Biology" ]
2023-07-05T00:00:00
https://arxiv.org/abs/2307.02175
https://arxiv.org/pdf/2307.02175v2
2307.02175
null
0
0
false
null
null
0
822191eb0e475024e980d71ca2c9754eb00c498a83d38f5529a96b725354c8be
[ "arxiv", "semantic_scholar" ]
Structural Property Prediction
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims to give an introduction into Structural Bioinformatics, which is where the previo...
[ "Maurits Dijkstra", "Punto Bawono", "Isabel Houtkamp", "Jose Gavaldá-Garciá", "Mascha Okounev", "Robbin Bouwmeester", "Bas Stringer", "Jaap Heringa", "Sanne Abeln", "K. Anton Feenstra", "Juami H. M. van Gils" ]
[ "q-bio.BM" ]
[ "Biology" ]
2023-07-05T00:00:00
https://arxiv.org/abs/2307.02172
https://arxiv.org/pdf/2307.02172v2
2307.02172
null
0
0
false
null
null
0
29aaefc8e021637a00efd7fff11e81207b59d9f4d9aa4a02983744fc1ab594a2
[ "arxiv", "semantic_scholar" ]
ALBERTI, a Multilingual Domain Specific Language Model for Poetry Analysis
The computational analysis of poetry is limited by the scarcity of tools to automatically analyze and scan poems. In a multilingual settings, the problem is exacerbated as scansion and rhyme systems only exist for individual languages, making comparative studies very challenging and time consuming. In this work, we pre...
[ "Javier de la Rosa", "Álvaro Pérez Pozo", "Salvador Ros", "Elena González-Blanco" ]
[ "cs.CL" ]
[ "Computer Science" ]
2023-07-03T00:00:00
https://arxiv.org/abs/2307.01387
https://arxiv.org/pdf/2307.01387v1
2307.01387
10.48550/arXiv.2307.01387
8
0
false
null
null
0.2386
c714534d49d494626999c2b5bef1b85eda6b63f907c37e0f72de4408c5c243a0
[ "arxiv", "semantic_scholar" ]
Protein-DNA binding sites prediction based on pre-trained protein language model and contrastive learning
Protein-DNA interaction is critical for life activities such as replication, transcription, and splicing. Identifying protein-DNA binding residues is essential for modeling their interaction and downstream studies. However, developing accurate and efficient computational methods for this task remains challenging. Impro...
[ "Yufan Liu", "Boxue Tian" ]
[ "q-bio.BM", "q-bio.QM" ]
[ "Computer Science", "Medicine", "Biology" ]
2023-06-28T00:00:00
https://arxiv.org/abs/2306.15912
https://arxiv.org/pdf/2306.15912v1
2306.15912
10.1093/bib/bbad488
61
7
true
https://github.com/YAndrewL/clape
null
0.4515
f75160157dcd663bc2a9ff5731e270fa8bc08480d6ea61b4a875280fa8dff6d8
[ "arxiv", "semantic_scholar" ]
WizardCoder: Empowering Code Large Language Models with Evol-Instruct
Code Large Language Models (Code LLMs), such as StarCoder, have demonstrated exceptional performance in code-related tasks. However, most existing models are solely pre-trained on extensive raw code data without instruction fine-tuning. In this paper, we introduce WizardCoder, which empowers Code LLMs with complex inst...
[ "Ziyang Luo", "Can Xu", "Pu Zhao", "Qingfeng Sun", "Xiubo Geng", "Wenxiang Hu", "Chongyang Tao", "Jing Ma", "Qingwei Lin", "Daxin Jiang" ]
[ "cs.CL", "cs.AI" ]
[ "Computer Science" ]
2023-06-14T00:00:00
https://arxiv.org/abs/2306.08568
https://arxiv.org/pdf/2306.08568v2
2306.08568
null
977
121
true
https://github.com/nlpxucan/WizardLM
International Conference on Learning Representations
1
9db460d1af736c051401613b8615638ff279f21b69b4179ca548436666064249
[ "arxiv", "semantic_scholar" ]
A Comprehensive Review of State-of-The-Art Methods for Java Code Generation from Natural Language Text
Java Code Generation consists in generating automatically Java code from a Natural Language Text. This NLP task helps in increasing programmers' productivity by providing them with immediate solutions to the simplest and most repetitive tasks. Code generation is a challenging task because of the hard syntactic rules an...
[ "Jessica López Espejel", "Mahaman Sanoussi Yahaya Alassan", "El Mehdi Chouham", "Walid Dahhane", "El Hassane Ettifouri" ]
[ "cs.CL" ]
[ "Computer Science" ]
2023-06-10T00:00:00
https://arxiv.org/abs/2306.06371
https://arxiv.org/pdf/2306.06371v1
2306.06371
10.1016/j.nlp.2023.100013
17
0
false
null
Natural Language Processing Journal
0.3138
8071b56548c07b7216e56ef0bac05ee8b9de4ffdf5b5d21634663515949a078d
[ "arxiv", "semantic_scholar" ]
Multi-level Protein Representation Learning for Blind Mutational Effect Prediction
Directed evolution plays an indispensable role in protein engineering that revises existing protein sequences to attain new or enhanced functions. Accurately predicting the effects of protein variants necessitates an in-depth understanding of protein structure and function. Although large self-supervised language model...
[ "Yang Tan", "Bingxin Zhou", "Yuanhong Jiang", "Yu Guang Wang", "Liang Hong" ]
[ "q-bio.QM", "cs.AI" ]
[ "Computer Science", "Biology" ]
2023-06-08T00:00:00
https://arxiv.org/abs/2306.04899
https://arxiv.org/pdf/2306.04899v1
2306.04899
10.48550/arXiv.2306.04899
3
0
false
null
arXiv.org
0.1505
63c3cfddf3d9d87820a32183a90cf09eafbcb096448027be5e58cb8551352036
[ "arxiv", "semantic_scholar" ]
Enhancing the Protein Tertiary Structure Prediction by Multiple Sequence Alignment Generation
The field of protein folding research has been greatly advanced by deep learning methods, with AlphaFold2 (AF2) demonstrating exceptional performance and atomic-level precision. As co-evolution is integral to protein structure prediction, AF2's accuracy is significantly influenced by the depth of multiple sequence alig...
[ "Le Zhang", "Jiayang Chen", "Tao Shen", "Yu Li", "Siqi Sun" ]
[ "q-bio.QM", "cs.CE", "cs.LG", "q-bio.BM" ]
[ "Biology", "Computer Science" ]
2023-06-02T00:00:00
https://arxiv.org/abs/2306.01824
https://arxiv.org/pdf/2306.01824v1
2306.01824
10.48550/arXiv.2306.01824
10
1
false
null
arXiv.org
0.2603