id stringlengths 10 13 | question_id stringlengths 10 13 | document_id stringlengths 10 13 | question stringlengths 23 23 | type stringclasses 1
value | choices list | context stringlengths 8.99k 109k | answer list |
|---|---|---|---|---|---|---|---|
MH_train_200 | MH_train_200 | MH_train_200 | interacts_with DB00796? | multiple_choice | [
"DB00278",
"DB00477",
"DB00712",
"DB00877",
"DB01032",
"DB01182",
"DB01281",
"DB01356",
"DB06643"
] | The influence of costimulation and regulatory P01730 + T cells on intestinal IgA immune responses . It is thought that IgA B-cell differentiation is highly dependent on activated P01730 + T cells . In particular , cell-cell interactions in the Peyer 's patches involving P25942 and/or P33681 / P42081 have been implicate... | [
"DB01356"
] |
MH_train_201 | MH_train_201 | MH_train_201 | interacts_with DB00428? | multiple_choice | [
"DB00472",
"DB00514",
"DB00620",
"DB00864",
"DB00946",
"DB00989",
"DB03880",
"DB04868",
"DB09053"
] | DB00197 inhibits vascular endothelial growth factor-induced angiogenic signaling via suppression of reactive oxygen species production and extracellular signal-regulated kinase phosphorylation in endothelial cells . Thiazolidinediones , peroxisome proliferators-activated receptor gamma ( PPARgamma ) ligands , have been... | [
"DB00864"
] |
MH_train_202 | MH_train_202 | MH_train_202 | interacts_with DB00451? | multiple_choice | [
"DB00207",
"DB00227",
"DB00266",
"DB00452",
"DB00501",
"DB00820",
"DB01120",
"DB04871",
"DB06616"
] | Polymorphism identification in the P11310 , P01008 , P22301 , P15173 and P01222 genes of cattle . Two thyroid hormone regulated genes , the beta-subunits of nerve growth factor ( P01138 ) and thyroid stimulating hormone ( P01222 ) , are located less than 310 kb apart in both human and mouse genomes . Two thyroid hormon... | [
"DB00266"
] |
MH_train_203 | MH_train_203 | MH_train_203 | interacts_with DB00674? | multiple_choice | [
"DB00317",
"DB00341",
"DB00382",
"DB00461",
"DB00630",
"DB01037",
"DB02546",
"DB06271",
"DB09068"
] | Induction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancer . Gefitinib ( DB00317 (®) , ZD1839 ) is a small molecule inhibitor of the epidermal growth factor receptor ( P00533 ) tyrosine kinase . We report on an early cellular response to gefitinib that involves inductio... | [
"DB09068"
] |
MH_train_204 | MH_train_204 | MH_train_204 | interacts_with DB08870? | multiple_choice | [
"DB00391",
"DB00459",
"DB00544",
"DB00951",
"DB01039",
"DB01050",
"DB01095",
"DB01128",
"DB01259"
] | Synergistic activity of ixabepilone plus other anticancer agents : preclinical and clinical evidence . DB04845 demonstrates marked synergistic activity in combination with capecitabine , which served as the rationale for the evaluation of this combination in the clinic . DB04845 plus capecitabine is currently approved ... | [
"DB01259"
] |
MH_train_205 | MH_train_205 | MH_train_205 | interacts_with DB09079? | multiple_choice | [
"DB00184",
"DB00338",
"DB00605",
"DB00784",
"DB01406",
"DB01656",
"DB06589",
"DB06684",
"DB09280"
] | Guggulsterone inhibits angiogenesis by blocking P40763 and P15692 expression in colon cancer cells . The plant sterol guggulsterone has been shown to exert anti-tumor effects , making it a candidate chemotherapeutic agent . We investigated the anti-tumor effects of guggulsterone on colon cancer cells and elucidated the... | [
"DB09280"
] |
MH_train_206 | MH_train_206 | MH_train_206 | interacts_with DB00998? | multiple_choice | [
"DB00290",
"DB00677",
"DB00762",
"DB00783",
"DB00977",
"DB01024",
"DB01114",
"DB01238",
"DB08815"
] | DB00998 Vernalis . Vanguard ( now Vernalis ) has developed frovatriptan , a selective P28222 /1D partial agonist licensed from GlaxoSmithKline as a potential treatment for migraine [ 188478 ] , [ 194382 ] , [ 377863 ] . DB00998 , a P28222 /1D receptor agonist for migraine . DB00998 is one of the most recent serotonin r... | [
"DB01238"
] |
MH_train_207 | MH_train_207 | MH_train_207 | interacts_with DB00099? | multiple_choice | [
"DB00588",
"DB00620",
"DB00834",
"DB01030",
"DB01200",
"DB06212",
"DB06779",
"DB06822",
"DB08910"
] | Dopamine agonist-induced hypothermia and disruption of prepulse inhibition : evidence for a role of D3 receptors ? The dopamine D3/D2 receptor agonists 7-OH-DPAT , quinpirole , quinelorane , and PD128907 , the mixed dopamine agonist apomorphine , the D2 agonist bromocriptine , and the D1/D5 agonist SKF38393 were examin... | [
"DB01030"
] |
MH_train_208 | MH_train_208 | MH_train_208 | interacts_with DB06692? | multiple_choice | [
"DB00502",
"DB00559",
"DB00909",
"DB01151",
"DB01197",
"DB01285",
"DB04839",
"DB08827",
"DB08877"
] | A Q8NBP7 -binding antibody that structurally mimics the P01133 (A) domain of LDL-receptor reduces LDL cholesterol in vivo . Proprotein convertase subtilisin-like/kexin type 9 ( Q8NBP7 ) regulates LDL cholesterol levels by inhibiting P01130 ( LDLr ) -mediated cellular LDL uptake . We have identified a fragment antigen-b... | [
"DB01197"
] |
MH_train_209 | MH_train_209 | MH_train_209 | interacts_with DB00153? | multiple_choice | [
"DB00035",
"DB00215",
"DB00707",
"DB00991",
"DB01067",
"DB01406",
"DB01590",
"DB02901",
"DB06144"
] | Relative Expression of Vitamin D Hydroxylases , O15528 and Q07973 , and of P35354 and Heterogeneity of Human Colorectal Cancer in Relation to Age , Gender , Tumor Location , and Malignancy : Results from Factor and Cluster Analysis . Previous studies on the significance of vitamin D insufficiency and chronic inflammati... | [
"DB01406"
] |
MH_train_210 | MH_train_210 | MH_train_210 | interacts_with DB09030? | multiple_choice | [
"DB00031",
"DB00175",
"DB00191",
"DB00293",
"DB00563",
"DB00819",
"DB00850",
"DB04844",
"DB06287"
] | Clot penetration and retention by plasminogen activators promote fibrinolysis . P00750 ( tPA ) remains the sole thrombolytic approved by the FDA for the treatment of pulmonary embolism (PE). tPA has not been replaced by third generation plasminogen activators , e.g. DB00015 ( Ret ) and DB00031 ( TNK ) that circulate wi... | [
"DB00031"
] |
MH_train_211 | MH_train_211 | MH_train_211 | interacts_with DB00360? | multiple_choice | [
"DB00086",
"DB00203",
"DB00622",
"DB00912",
"DB01171",
"DB01267",
"DB05039",
"DB08881",
"DB09073"
] | DB00360 regulation of P29474 redox function . DB00360 ( BH4 ) is an essential cofactor of nitric oxide synthase ( NOS ) . In the cardiovascular system , endothelial NOS ( P29474 ) has a major role in maintaining vascular tone and endothelial function , as well as in mediating many other vascular protective properties .... | [
"DB00203"
] |
MH_train_212 | MH_train_212 | MH_train_212 | interacts_with DB00480? | multiple_choice | [
"DB00351",
"DB00459",
"DB00988",
"DB01109",
"DB01296",
"DB01656",
"DB02546",
"DB04908",
"DB06209"
] | P06401 level as a predictor of response to megestrol acetate in advanced breast cancer : a retrospective study . DB00351 ( 160 mg/day ) produced a response rate of 44 % in a retrospective series of 39 evaluable patients with advanced breast cancer . The estrogen-receptor ( ER ) level was greater than 10 fmols/mg of pro... | [
"DB01656"
] |
MH_train_213 | MH_train_213 | MH_train_213 | interacts_with DB06825? | multiple_choice | [
"DB00333",
"DB00877",
"DB01024",
"DB01032",
"DB01050",
"DB01120",
"DB01182",
"DB06212",
"DB09280"
] | Improvement of chloride transport defect by gonadotropin-releasing hormone ( DB00644 ) in cystic fibrosis epithelial cells . Cystic fibrosis ( CF ) , the most common autosomal recessive disease in Caucasians , is due to mutations in the P13569 gene . F508del , the most frequent mutation in patients , impairs P13569 pro... | [
"DB01120"
] |
MH_train_214 | MH_train_214 | MH_train_214 | interacts_with DB00549? | multiple_choice | [
"DB00290",
"DB00382",
"DB00559",
"DB00619",
"DB00712",
"DB00741",
"DB00977",
"DB01109",
"DB09073"
] | S-sulfhydration of Q02750 leads to P09874 activation and DNA damage repair . The repair of DNA damage is fundamental to normal cell development and replication . Hydrogen sulfide ( H2S ) is a novel gasotransmitter that has been reported to protect cellular aging . Here , we show that H2S attenuates DNA damage in human ... | [
"DB00559"
] |
MH_train_215 | MH_train_215 | MH_train_215 | interacts_with DB00594? | multiple_choice | [
"DB00007",
"DB00341",
"DB00422",
"DB00486",
"DB00668",
"DB00707",
"DB00988",
"DB00991",
"DB08816"
] | [ Prominent features of management strategies in acute coronary syndromes with the new oral antiplatelet agents ] . The novel oral Q9H244 inhibitors ( prasugrel and ticagrelor ) have been incorporated into the recently updated acute coronary syndrome ( ACS ) guidelines , as an adjunct antiplatelet treatment to aspirin ... | [
"DB00422"
] |
MH_train_216 | MH_train_216 | MH_train_216 | interacts_with DB01248? | multiple_choice | [
"DB00015",
"DB00086",
"DB00233",
"DB00379",
"DB00501",
"DB00620",
"DB00784",
"DB00863",
"DB09048"
] | P04626 / P21860 signaling regulates NK cell-mediated cytotoxicity via MHC class I chain-related molecule A and B expression in human breast cancer cell lines . Overexpression of the receptor tyrosine kinases P04626 and P21860 is associated with a poor prognosis in several types of cancer . Presently , P04626 - as well ... | [
"DB09048"
] |
MH_train_217 | MH_train_217 | MH_train_217 | interacts_with DB01407? | multiple_choice | [
"DB00191",
"DB00461",
"DB00502",
"DB00677",
"DB00904",
"DB00909",
"DB01037",
"DB06822",
"DB08879"
] | Effects of phenytoin , ketamine , and atropine methyl nitrate in preventing neuromuscular toxicity of acetylcholinesterase inhibitors soman and diisopropylphosphorofluoridate . Toxic manifestations of acetylcholinesterase inhibitors ( P22303 -I ) include muscle twitching and muscle fiber necrosis , in addition to musca... | [
"DB00191"
] |
MH_train_218 | MH_train_218 | MH_train_218 | interacts_with DB00153? | multiple_choice | [
"DB00227",
"DB00495",
"DB00682",
"DB01098",
"DB01238",
"DB06209",
"DB08827",
"DB08881",
"DB08910"
] | Inhibitory effects of imatinib on vitamin D₃ synthesis in human keratinocytes . Chronic myeloid leukemia ( CML ) is a myeloproliferative disease characterized by the presence of the BCR‑ P00519 fusion gene , a constitutively active , oncogenic tyrosine kinase that is responsible for the clinical features of CML . Tyros... | [
"DB00682"
] |
MH_train_219 | MH_train_219 | MH_train_219 | interacts_with DB00773? | multiple_choice | [
"DB00278",
"DB00313",
"DB00472",
"DB00477",
"DB00989",
"DB01114",
"DB01259",
"DB06643",
"DB08815"
] | An important role for P24941 in P55008 to S checkpoint activation and DNA damage response in human embryonic stem cells . A precise understanding of mechanisms used by human embryonic stem cells ( hESCs ) to maintain genomic integrity is very important for their potential clinical applications . The P55008 checkpoint s... | [
"DB06643"
] |
MH_train_220 | MH_train_220 | MH_train_220 | interacts_with DB06288? | multiple_choice | [
"DB00009",
"DB00104",
"DB00222",
"DB01267",
"DB04839",
"DB06271",
"DB06287",
"DB06616",
"DB08899"
] | Modeling of Q14654 and inhibition mechanism of the natural ligand , ellagic acid , using molecular docking . Diabetes mellitus is a disorder in which blood sugar ( glucose ) levels are abnormally high because the body does not produce enough insulin to meet its needs . Post-prandial hyperglycemia ( PPHG ) is an indepen... | [
"DB01267"
] |
MH_train_221 | MH_train_221 | MH_train_221 | interacts_with DB06655? | multiple_choice | [
"DB00007",
"DB00175",
"DB00316",
"DB00351",
"DB01285",
"DB01418",
"DB01576",
"DB04905",
"DB06779"
] | DB06655 : clinical pharmacology and considerations for therapy . DB06655 is a United States Food and Drug Administration ( FDA ) -approved glucagon-like peptide-1 ( P0C6A0 ) analog that is 97 % homologous to native human P0C6A0 . The additional 16-carbon fatty acid chain causes noncovalent binding to albumin , which sl... | [
"DB00007"
] |
MH_train_222 | MH_train_222 | MH_train_222 | interacts_with DB00216? | multiple_choice | [
"DB00317",
"DB00544",
"DB00762",
"DB00834",
"DB00912",
"DB01128",
"DB06684",
"DB08907",
"DB09026"
] | Effect of canagliflozin on renal threshold for glucose , glycemia , and body weight in normal and diabetic animal models . BACKGROUND : DB08907 is a sodium glucose co-transporter ( SGLT ) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus ( T2DM ) . METHODS : (14)C-alpha-methylglucoside u... | [
"DB00834"
] |
MH_train_223 | MH_train_223 | MH_train_223 | interacts_with DB01169? | multiple_choice | [
"DB00203",
"DB00322",
"DB00514",
"DB00630",
"DB01016",
"DB01197",
"DB01296",
"DB05039",
"DB09068"
] | DB01296 sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis . BACKGROUND : DB01296 sulfate may have an ex vivo inhibitory effect on the plasminogen activator ( PA ) /plasmin system and gelatinases expression during the early develo... | [
"DB01016"
] |
MH_train_224 | MH_train_224 | MH_train_224 | interacts_with DB08932? | multiple_choice | [
"DB00734",
"DB00758",
"DB00864",
"DB01151",
"DB01356",
"DB01590",
"DB03880",
"DB04871",
"DB08820"
] | P25116 activation inhibits monocyte spreading by induction of ET(B) receptor-coupled nitric oxide release . The effect of thrombin receptor activation on monocyte conformation was evaluated using the human monocyte cell line , THP-1 , and the thrombin mimetic peptide , Q8NHU6 -14 . Treatment of THP-1 cells with Q8NHU6 ... | [
"DB08820"
] |
MH_train_225 | MH_train_225 | MH_train_225 | interacts_with DB05812? | multiple_choice | [
"DB00031",
"DB00391",
"DB00603",
"DB00622",
"DB00623",
"DB00783",
"DB01393",
"DB04868",
"DB08877"
] | DB05812 inhibits 1α,25-dihydroxyvitamin D3 metabolism by P08684 in human liver and intestine in vitro . The chemopreventive and therapeutic effects of vitamin D3 are exerted through its dihydroxylated metabolite , 1α,25-dihydroxyvitamin D3 [ 1α,25(OH)2D3 ] . Inactivation of 1α,25(OH)2D3 by cytochrome P450 3A4 ( P08684 ... | [
"DB00623"
] |
MH_train_226 | MH_train_226 | MH_train_226 | interacts_with DB00368? | multiple_choice | [
"DB00072",
"DB00215",
"DB00266",
"DB00563",
"DB00588",
"DB00755",
"DB00946",
"DB01076",
"DB04946"
] | Molecular systematics of armadillos ( Xenarthra , Dasypodidae ) : contribution of maximum likelihood and Bayesian analyses of mitochondrial and nuclear genes . The 30 living species of armadillos , anteaters , and sloths ( Mammalia : Xenarthra ) represent one of the three major clades of placentals . Armadillos ( Cingu... | [
"DB00588"
] |
MH_train_227 | MH_train_227 | MH_train_227 | interacts_with DB01221? | multiple_choice | [
"DB00293",
"DB00294",
"DB00452",
"DB00819",
"DB01171",
"DB01200",
"DB02901",
"DB04844",
"DB09048"
] | Agonist-induced glycogenolysis in rabbit retinal slices and cultures . 1. The effects of different putative retinal transmitters and/or modulators on glycogenolysis in rabbit retinal slices and in retinal Müller cell cultures were examined . 2 . Incubation of rabbit retinal slices or primary retinal cultures ( either 3... | [
"DB09048"
] |
MH_train_228 | MH_train_228 | MH_train_228 | interacts_with DB08918? | multiple_choice | [
"DB00184",
"DB00207",
"DB00338",
"DB00605",
"DB00820",
"DB00951",
"DB01039",
"DB01095",
"DB06144"
] | Metabolic stress modulates Alzheimer 's β-secretase gene transcription via Q96EB6 -PPARγ- P20142 -1 in neurons . Classic cardio-metabolic risk factors such as hypertension , stroke , diabetes , and hypercholesterolemia all increase the risk of Alzheimer 's disease . We found increased transcription of β-secretase/ P568... | [
"DB06144"
] |
MH_train_229 | MH_train_229 | MH_train_229 | interacts_with DB01240? | multiple_choice | [
"DB00035",
"DB00563",
"DB00622",
"DB00850",
"DB01067",
"DB01109",
"DB01281",
"DB06589",
"DB09053"
] | Human prostacyclin receptor . DB01240 , a member of the eicosanoid family of lipid mediators , is the major product of arachidonic acid metabolism formed in the marcovascular endothelium . It is a potent vasodilator , antithrombotic , and antiplatelet agent that mediates it effects through a membrane-associated recepto... | [
"DB01109"
] |
MH_train_230 | MH_train_230 | MH_train_230 | interacts_with DB00159? | multiple_choice | [
"DB00175",
"DB00382",
"DB00486",
"DB00502",
"DB01067",
"DB01197",
"DB04905",
"DB06684",
"DB09026"
] | DB00171 -sensitive potassium channels ( K( DB00171 ) ) in retina : a key role for delayed ischemic tolerance . The objectives of the present study were to determine the localization of K( DB00171 ) channels in normal retina and to evaluate their potential roles in ischemic preconditioning ( IPC ) in a rat model of isch... | [
"DB06684"
] |
MH_train_231 | MH_train_231 | MH_train_231 | interacts_with DB00549? | multiple_choice | [
"DB00317",
"DB00379",
"DB00677",
"DB00682",
"DB00762",
"DB00819",
"DB00946",
"DB01656",
"DB06287"
] | Gating properties of Q14524 mutations and the response to mexiletine in long-QT syndrome type 3 patients . BACKGROUND : DB00379 ( Mex ) has been proposed as a gene-specific therapy for patients with long-QT syndrome type 3 ( LQT3 ) caused by mutations in the cardiac sodium channel gene ( Q14524 ) . The degree of QT sho... | [
"DB00682"
] |
MH_train_232 | MH_train_232 | MH_train_232 | interacts_with DB04835? | multiple_choice | [
"DB00015",
"DB00035",
"DB00338",
"DB00904",
"DB01128",
"DB01356",
"DB01406",
"DB08820",
"DB08907"
] | Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques . OBJECTIVES : To investigate the pharmacokinetics ( PK ) of maraviroc , a P51681 -targeted HIV-1 entry inhibitor , in rhesus macaques following vaginal administration of various maraviroc-loaded aqueous DB11602 ( O14777 ) gels ,... | [
"DB08820"
] |
MH_train_233 | MH_train_233 | MH_train_233 | interacts_with DB09078? | multiple_choice | [
"DB00184",
"DB00322",
"DB00461",
"DB00834",
"DB00912",
"DB01182",
"DB01238",
"DB04868",
"DB04908"
] | P11362 - 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity . BACKGROUND : The hippocampus and its 5-hydroxytryptamine transmission plays an important role in depression related to its involvement in limbic circuit plasticity . METHODS : The analysis was made with biolumines... | [
"DB00834"
] |
MH_train_234 | MH_train_234 | MH_train_234 | interacts_with DB00624? | multiple_choice | [
"DB00072",
"DB00278",
"DB00313",
"DB00316",
"DB00588",
"DB00734",
"DB00783",
"DB01200",
"DB03880"
] | Glucocorticoid-induced surface expression of annexin 1 blocks beta2-integrin adhesion of human eosinophils to intercellular adhesion molecule 1 surrogate protein . BACKGROUND : Glucocorticoids attenuate the population of eosinophils and T lymphocytes in asthmatic airways . The decrease in airway eosinophilia is caused ... | [
"DB01200"
] |
MH_train_235 | MH_train_235 | MH_train_235 | interacts_with DB06366? | multiple_choice | [
"DB00215",
"DB00472",
"DB00707",
"DB01114",
"DB02546",
"DB04871",
"DB06616",
"DB08879",
"DB09068"
] | Identification of an acetylation-dependant P12956 /FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis . FLIP is a potential anti-cancer therapeutic target that inhibits apoptosis by blocking caspase 8 activation by death receptors . We report a novel interaction between FLIP and the DNA re... | [
"DB08879"
] |
MH_train_236 | MH_train_236 | MH_train_236 | interacts_with DB00731? | multiple_choice | [
"DB00266",
"DB00712",
"DB01037",
"DB01151",
"DB01171",
"DB01211",
"DB08816",
"DB08910",
"DB09073"
] | Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance . Adipose tissue expresses tumor necrosis factor ( P01375 ) and interleukin ( IL ) -6 , which may cause obesity-related insulin resistance . We measured P01375 and P05231 expression in the adipose tissue of 50 lean... | [
"DB09073"
] |
MH_train_237 | MH_train_237 | MH_train_237 | interacts_with DB00074? | multiple_choice | [
"DB00501",
"DB00850",
"DB00864",
"DB00989",
"DB01267",
"DB01285",
"DB01590",
"DB04946",
"DB08877"
] | Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB . Adult T-cell leukemia ( ATL ) is a highly aggressive T-cell malignancy caused by human T-cell leukemia virus type 1 ( HTLV-1 ) . The activation of NF-kappaB by Tax has been reported to play a crucial role in HTLV-... | [
"DB00864"
] |
MH_train_238 | MH_train_238 | MH_train_238 | interacts_with DB00169? | multiple_choice | [
"DB00086",
"DB00207",
"DB00233",
"DB00559",
"DB00863",
"DB01406",
"DB05039",
"DB06144",
"DB08899"
] | Expression of Th2-skewed pathology mediators in monocyte-derived type 2 of dendritic cells ( DC2 ) . The information conveyed from dendritic cells ( DCs ) to naïve P01730 (+) T cells has crucial influence on their differentiation toward effector T cells . In an effort to identify DC-derived molecules directly contribut... | [
"DB01406"
] |
MH_train_239 | MH_train_239 | MH_train_239 | interacts_with DB00973? | multiple_choice | [
"DB00293",
"DB00422",
"DB00977",
"DB01032",
"DB01039",
"DB01281",
"DB06209",
"DB06589",
"DB08881"
] | miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1 . MicroRNAs ( miRNAs ) are short noncoding RNAs that play crucial roles in tumorigenesis and tumor progression . Melanoma is the most aggressive skin cancer that is resistant or rapidly develops resistance to a variety of chemot... | [
"DB01039"
] |
MH_train_240 | MH_train_240 | MH_train_240 | interacts_with DB06480? | multiple_choice | [
"DB00341",
"DB00495",
"DB00741",
"DB00758",
"DB01095",
"DB01576",
"DB04908",
"DB06643",
"DB06779"
] | Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women . Heterosexual transmission of human immunodeficiency virus ( HIV-1 ) is the predominant mode of infection world-wide . To better understand sexual transmission of HIV-1 in women we h... | [
"DB04908"
] |
MH_train_241 | MH_train_241 | MH_train_241 | interacts_with DB03615? | multiple_choice | [
"DB00009",
"DB00294",
"DB00351",
"DB00668",
"DB00951",
"DB00991",
"DB01024",
"DB04839",
"DB04844"
] | P06401 level as a predictor of response to megestrol acetate in advanced breast cancer : a retrospective study . DB00351 ( 160 mg/day ) produced a response rate of 44 % in a retrospective series of 39 evaluable patients with advanced breast cancer . The estrogen-receptor ( ER ) level was greater than 10 fmols/mg of pro... | [
"DB00991"
] |
MH_train_242 | MH_train_242 | MH_train_242 | interacts_with DB01407? | multiple_choice | [
"DB00031",
"DB00104",
"DB00391",
"DB00514",
"DB00605",
"DB00623",
"DB00988",
"DB01076",
"DB08815"
] | Normal and perturbed endothelial cells from canine femoral arteries and femoral veins exhibit heterogeneity in hemostatic properties and growth characteristics . BACKGROUND : We sought to examine the heterogeneity of endothelial cells from the same anatomic site but different vascular systems and described P04275 ( P04... | [
"DB00988"
] |
MH_train_243 | MH_train_243 | MH_train_243 | interacts_with DB00482? | multiple_choice | [
"DB00191",
"DB00203",
"DB00222",
"DB00290",
"DB00459",
"DB00755",
"DB06822",
"DB09053",
"DB09280"
] | Expression of vitamin D3 receptor and retinoid receptors in human breast cancer : identification of potential heterodimeric receptors . DB00169 ( VD ) and all-trans-retinoic acid ( DB00755 ) have been postulated as a novel treatment option for breast carcinoma . Since the combined effects of retinoids and VD derivative... | [
"DB09280"
] |
MH_train_244 | MH_train_244 | MH_train_244 | interacts_with DB06441? | multiple_choice | [
"DB00544",
"DB00603",
"DB00630",
"DB00877",
"DB01030",
"DB01098",
"DB01296",
"DB01393",
"DB06212"
] | The P04035 inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes . Human preadipocytes and adipocytes are known to produce the proatherogenic factor P05121 and proinflammatory cytokines , and obesity was found to be state of increased adipose production of these ... | [
"DB01296"
] |
MH_train_245 | MH_train_245 | MH_train_245 | interacts_with DB01022? | multiple_choice | [
"DB00203",
"DB00227",
"DB00333",
"DB00477",
"DB00784",
"DB01016",
"DB01050",
"DB01418",
"DB08827"
] | Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-α in children . BACKGROUND : P02818 , a protein secreted by osteoblasts during bone formation , is negatively associated with adult periodontal disease . Little is known about this association in children . AIM : To examine t... | [
"DB01418"
] |
MH_train_246 | MH_train_246 | MH_train_246 | interacts_with DB00051? | multiple_choice | [
"DB00233",
"DB00333",
"DB00619",
"DB00820",
"DB00864",
"DB00877",
"DB00909",
"DB01259",
"DB08910"
] | Nearly Complete Response of Brain Metastases from P04626 Overexpressing Breast Cancer with DB01259 and DB01101 after Whole Brain Irradiation . DB00072 treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in P04626 overexpressing breast cancer patie... | [
"DB00864"
] |
MH_train_247 | MH_train_247 | MH_train_247 | interacts_with DB00083? | multiple_choice | [
"DB00072",
"DB00215",
"DB00422",
"DB00605",
"DB00755",
"DB00850",
"DB01120",
"DB01393",
"DB06271"
] | Evidence for anterograde transport and transcytosis of botulinum neurotoxin A ( DB00083 ) . Botulinum neurotoxin type A ( DB00083 ) is a metalloprotease that blocks synaptic transmission via the cleavage of P60880 ( synaptosomal-associated protein of 25 kDa ) . DB00083 is successfully used in clinical neurology for the... | [
"DB00850"
] |
MH_train_248 | MH_train_248 | MH_train_248 | interacts_with DB00360? | multiple_choice | [
"DB00452",
"DB00501",
"DB00502",
"DB00820",
"DB01576",
"DB04871",
"DB06144",
"DB08816",
"DB08907"
] | P25021 overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate DB02527 signalling . Knowing that cell-surface receptors that recognize and respond to extracellular stimuli are key components for the regular communication between individual cells required for the survival of any living... | [
"DB00820"
] |
MH_train_249 | MH_train_249 | MH_train_249 | interacts_with DB06692? | multiple_choice | [
"DB00009",
"DB00622",
"DB00762",
"DB00977",
"DB00988",
"DB01109",
"DB01281",
"DB02546",
"DB02901"
] | Stage-dependent inhibition of Plasmodium falciparum by potent Ca2+ and calmodulin modulators . The effects of Ca2+ channel blockers , verapamil , nicardipine and diltiazem , and of potent calmodulin ( P62158 ) inhibitors , trifluoperazine ( Q9HCM9 ) , calmidazolium , W-7 and W-5 , on Plasmodium falciparum in culture we... | [
"DB00009"
] |
MH_train_250 | MH_train_250 | MH_train_250 | interacts_with DB00146? | multiple_choice | [
"DB00278",
"DB00317",
"DB00682",
"DB00784",
"DB00946",
"DB02901",
"DB04946",
"DB06684",
"DB06779"
] | P00734 in normal human cerebrospinal fluid originates from the blood . In spite of the fact that prothrombin is produced by cells within the central nervous system , its presence in the cerebrospinal fluid ( P04141 ) has not been investigated . We determined the concentration of prothrombin in P04141 with reference to ... | [
"DB00682"
] |
MH_train_251 | MH_train_251 | MH_train_251 | interacts_with DB01241? | multiple_choice | [
"DB00191",
"DB00227",
"DB00477",
"DB01211",
"DB06287",
"DB06616",
"DB08881",
"DB09048",
"DB09053"
] | [ Functional characteristics of calcium-sensitive adenylyl cyclase of ciliate Tetrahymena pyriformis ] . DB01373 -sensitive forms of adenylyl cyclase ( AC ) were revealed in most vertebrates and invertebrates and also in some unicellular organisms , in particular ciliates . We have shown for the first time that calcium... | [
"DB00227"
] |
MH_train_252 | MH_train_252 | MH_train_252 | interacts_with DB09030? | multiple_choice | [
"DB00222",
"DB00382",
"DB00495",
"DB00834",
"DB00909",
"DB01032",
"DB01067",
"DB01128",
"DB01296"
] | Thrombin-induced DB00171 release from human umbilical vein endothelial cells . DB00171 and its degradation products play an important role as signaling molecules in the vascular system , and endothelial cells are considered to be an important source of nucleotide release . To investigate the mechanism and physiological... | [
"DB01296"
] |
MH_train_253 | MH_train_253 | MH_train_253 | interacts_with DB00921? | multiple_choice | [
"DB00486",
"DB00544",
"DB00630",
"DB01016",
"DB01024",
"DB01030",
"DB01095",
"DB01182",
"DB08877"
] | DB01095 inhibits growth and alters the malignant phenotype of the P13671 glioma cell line . BACKGROUND : DB01095 is a member of the family of P04035 inhibitors ( statins ) extensively used in medical practice . Increasing evidence suggests that fluvastatin may be implicated in suppression of cancer growth and developme... | [
"DB00486"
] |
MH_train_254 | MH_train_254 | MH_train_254 | interacts_with DB01367? | multiple_choice | [
"DB00007",
"DB00031",
"DB00184",
"DB00316",
"DB00341",
"DB00904",
"DB06643",
"DB08827",
"DB09073"
] | Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA . We developed , synthesized , and tested a multifunctional nanostructured lipid nanocarrier-based system ( NLCS ) for efficient delivery of an anticancer drug and siRNA directly into the lungs... | [
"DB00904"
] |
MH_train_255 | MH_train_255 | MH_train_255 | interacts_with DB06674? | multiple_choice | [
"DB00015",
"DB00712",
"DB00783",
"DB00819",
"DB01098",
"DB01120",
"DB01656",
"DB04839",
"DB06212"
] | Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent DB05876 inhibitors . 2-Phenyl-4-piperidinyl-6,7-dihydrothieno[3,4-d]pyrimidine derivative ( 2 ) was found to be a new DB05876 inhibitor with moderate Q07343 activity ( IC50=150 nM ) . A number of derivatives with a variety o... | [
"DB01656"
] |
MH_train_256 | MH_train_256 | MH_train_256 | interacts_with DB00242? | multiple_choice | [
"DB00035",
"DB00175",
"DB00514",
"DB00603",
"DB01200",
"DB04868",
"DB06209",
"DB06643",
"DB09026"
] | Human gray matter : feasibility of single-slab 3D double inversion-recovery high-spatial-resolution MR imaging . The purpose of this study was to develop and prospectively evaluate the feasibility of a single-slab three-dimensional ( 3D ) double inversion-recovery , or P30518 , sequence for magnetic resonance imaging a... | [
"DB06643"
] |
MH_train_257 | MH_train_257 | MH_train_257 | interacts_with DB01278? | multiple_choice | [
"DB00459",
"DB00559",
"DB00951",
"DB00989",
"DB01171",
"DB01267",
"DB01285",
"DB04908",
"DB09280"
] | Potentiator ivacaftor abrogates pharmacological correction of ΔF508 P13569 in cystic fibrosis . Cystic fibrosis ( CF ) is caused by mutations in the CF transmembrane conductance regulator ( P13569 ) . Newly developed " correctors " such as DB09280 ( VX-809 ) that improve P13569 maturation and trafficking and " potentia... | [
"DB01171"
] |
MH_train_258 | MH_train_258 | MH_train_258 | interacts_with DB06681? | multiple_choice | [
"DB00294",
"DB00461",
"DB00668",
"DB00741",
"DB00912",
"DB01039",
"DB01076",
"DB01418",
"DB01656"
] | Expression of cyclooxygenase-2 in urinary bladder in rats with cyclophosphamide-induced cystitis . These studies examined the expression of cyclooxygenase-2 ( P35354 ) expression in the urothelium and suburothelial space and detrusor from rats treated with cyclophosphamide ( CYP ) to induce acute ( 4 h ) , intermediate... | [
"DB01656"
] |
MH_train_259 | MH_train_259 | MH_train_259 | interacts_with DB09079? | multiple_choice | [
"DB00266",
"DB00322",
"DB00391",
"DB00619",
"DB00623",
"DB01037",
"DB01114",
"DB05039",
"DB08820"
] | [ The role of matrix metalloproteinases and their inhibitors in pathogenesis of pancreatic pseudocysts ] . The investigation was conducted in 47 patients , operated on for pancreatic pseudocysts ( PP ) . Activity of matrix metalloproteinases ( P14780 ) and content of their tissue inhibitor ( P16035 ) were determined in... | [
"DB00266"
] |
MH_train_260 | MH_train_260 | MH_train_260 | interacts_with DB01276? | multiple_choice | [
"DB00007",
"DB00452",
"DB00472",
"DB00863",
"DB00991",
"DB04905",
"DB06589",
"DB06822",
"DB08879"
] | Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line . To examine the influence of the putative satiety factor ( P0C6A0 ) on the hypothalamo-pituitary-gonadal axis , we used GT1-7 cells as a model of neuronal luteinizing hormone- releasing hormon... | [
"DB00007"
] |
MH_train_261 | MH_train_261 | MH_train_261 | interacts_with DB00163? | multiple_choice | [
"DB00207",
"DB00290",
"DB00313",
"DB00379",
"DB00677",
"DB00734",
"DB01238",
"DB08899",
"DB09068"
] | Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines . Q07869 involvement in cell growth was investigated " in vivo " and " in vitro " and was correlated with cell proliferation and apoptotic death . " In vivo " PPARgamma and alpha were evaluated i... | [
"DB09068"
] |
MH_train_262 | MH_train_262 | MH_train_262 | interacts_with DB00966? | multiple_choice | [
"DB00293",
"DB00588",
"DB00707",
"DB00758",
"DB01050",
"DB01356",
"DB03880",
"DB04844",
"DB06271"
] | Prevention of thrombus formation and growth by antithrombin III and heparin cofactor II-dependent thrombin inhibitors : importance of heparin cofactor II . DB01109 ( HEP ) prevents thrombus formation ( TF ) and thrombus growth ( TG ) , by accelerating thrombin ( THR ) inhibition by antithrombin III ( P01008 ) . Recent ... | [
"DB01356"
] |
MH_train_263 | MH_train_263 | MH_train_263 | interacts_with DB00279? | multiple_choice | [
"DB00086",
"DB00104",
"DB00338",
"DB00351",
"DB01076",
"DB01151",
"DB01197",
"DB01590",
"DB08815"
] | Downregulation of protein tyrosine phosphatase Q12923 alters cell cycle and upregulates invasion-related genes in prostate cancer cells . Q12923 , a non-receptor type protein tyrosine phosphatase , has been involved in the regulation of apoptosis and invasiveness of various tumour cell types , but its role in prostate ... | [
"DB01151"
] |
MH_train_264 | MH_train_264 | MH_train_264 | interacts_with DB00328? | multiple_choice | [
"DB00104",
"DB00351",
"DB00391",
"DB00563",
"DB00741",
"DB00758",
"DB00951",
"DB01050",
"DB01259"
] | [ DB00391 in the management of functional dyspepsia and delayed gastric emptying ] . DB00391 is a sulpiride isomer that exerts its prokinetic action through a dual mechanism : 1 ) as a P14416 antagonist and 2 ) as a serotonin 5HT(4) receptor agonist , conferring this drug with a cholinergic effect . At a dosage of 25mg... | [
"DB00563"
] |
MH_train_265 | MH_train_265 | MH_train_265 | interacts_with DB08439? | multiple_choice | [
"DB00009",
"DB00477",
"DB00514",
"DB00563",
"DB00682",
"DB00863",
"DB00904",
"DB04871",
"DB09026"
] | Cytochromes P450 are differently expressed in normal and varicose human saphenous veins : linkage with varicosis . The expression of cytochrome P450 ( CYP ) enzymes and cyclo-oxygenases ( P36551 ) was investigated in human saphenous veins by reverse transcription-polymerase chain reaction analysis . Non-varicose veins ... | [
"DB00514"
] |
MH_train_266 | MH_train_266 | MH_train_266 | interacts_with DB09052? | multiple_choice | [
"DB00072",
"DB00382",
"DB00544",
"DB00755",
"DB00762",
"DB01016",
"DB06589",
"DB08899",
"DB09048"
] | Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes . We developed concise , accurate prediction models of the in vitro activity for 8 anticancer drugs ( DB00544 , DB00515 , DB00305 , DOX , CPT-11 , SN-38 , TXL and TXT ) , along with individual clinical responses to ... | [
"DB00072"
] |
MH_train_267 | MH_train_267 | MH_train_267 | interacts_with DB00714? | multiple_choice | [
"DB00495",
"DB00605",
"DB00619",
"DB00834",
"DB01067",
"DB01098",
"DB04905",
"DB08907",
"DB08910"
] | Polyamines and membrane transporters . In recent years , our understanding of the importance of membrane transporters ( MTs ) in the disposition of and response to drugs has increased significantly . MTs are proteins that regulate the transport of endogenous molecules and xenobiotics across the cell membrane . In mamma... | [
"DB00834"
] |
MH_train_268 | MH_train_268 | MH_train_268 | interacts_with DB00641? | multiple_choice | [
"DB00227",
"DB00293",
"DB00559",
"DB00819",
"DB00850",
"DB00977",
"DB00989",
"DB01114",
"DB09280"
] | DB00227 . A preliminary review of its pharmacodynamic properties and therapeutic use in hyperlipidaemia . DB00227 is the first of a new class of cholesterol lowering drugs that competitively inhibit P04035 . This new drug decreases cholesterol synthesis and apolipoprotein B concentrations , and increases P01130 activit... | [
"DB00559"
] |
MH_train_269 | MH_train_269 | MH_train_269 | interacts_with DB00530? | multiple_choice | [
"DB00086",
"DB00184",
"DB00622",
"DB00630",
"DB00909",
"DB04908",
"DB04946",
"DB08816",
"DB08820"
] | Enhanced sensitivity to the P00533 /epidermal growth factor receptor tyrosine kinase inhibitor erlotinib hydrochloride in chemotherapy-resistant tumor cell lines . PURPOSE : Erlotinib ( Tarceva , DB00530 ) is a potent and specific inhibitor of the P00533 /epidermal growth factor receptor ( P00533 ) tyrosine kinase . In... | [
"DB08820"
] |
MH_train_270 | MH_train_270 | MH_train_270 | interacts_with DB00205? | multiple_choice | [
"DB00203",
"DB00501",
"DB00820",
"DB01030",
"DB01032",
"DB01109",
"DB01197",
"DB06209",
"DB08879"
] | Persistence of Sulfadoxine- DB00205 Resistance Despite Reduction of Drug Pressure in Malawi . BACKGROUND : In 2007 , Malawi replaced sulfadoxine-pyrimethamine ( SP ) with an artemisinin-based combination therapy as the first-line treatment for uncomplicated Plasmodium falciparum malaria in response to failing SP effica... | [
"DB00203"
] |
MH_train_271 | MH_train_271 | MH_train_271 | interacts_with DB00136? | multiple_choice | [
"DB00175",
"DB00313",
"DB00783",
"DB00864",
"DB01039",
"DB01095",
"DB02546",
"DB04844",
"DB09073"
] | 1Alpha,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter . Although transactivation by the liganded vitamin D receptor ( P11473 ) is well described at the molecular level , the precise molecular mechanism of negative regulation by the liga... | [
"DB09073"
] |
MH_train_272 | MH_train_272 | MH_train_272 | interacts_with DB08870? | multiple_choice | [
"DB00233",
"DB00266",
"DB00734",
"DB00988",
"DB01024",
"DB01267",
"DB01296",
"DB06822",
"DB08881"
] | [ Immunoregulatory genes in autoimmune thyroid disease ] . Autoimmune thyroid diseases ( AITD ) has a strong genetic basis . Although several candidate genes have been studied , the AITD causing genes are still unknown . Major candidate immune regulatory genes include human leukocyte antigen ( HLA ) gene , Ig heavy cha... | [
"DB08881"
] |
MH_train_273 | MH_train_273 | MH_train_273 | interacts_with DB00098? | multiple_choice | [
"DB00015",
"DB00278",
"DB00316",
"DB00588",
"DB00712",
"DB00864",
"DB01285",
"DB03880",
"DB08815"
] | Glucocorticoid-induced surface expression of annexin 1 blocks beta2-integrin adhesion of human eosinophils to intercellular adhesion molecule 1 surrogate protein . BACKGROUND : Glucocorticoids attenuate the population of eosinophils and T lymphocytes in asthmatic airways . The decrease in airway eosinophilia is caused ... | [
"DB00864"
] |
MH_train_274 | MH_train_274 | MH_train_274 | interacts_with DB00082? | multiple_choice | [
"DB00338",
"DB00461",
"DB00502",
"DB00707",
"DB00877",
"DB01182",
"DB01200",
"DB02901",
"DB06144"
] | DB00082 : current and potential novel therapeutic applications . BACKGROUND : DB00082 is a genetically engineered molecule , which exhibits specific growth hormone ( GH ) antagonism by directly interacting with the P10912 . It is currently licensed for the treatment of acromegaly where surgery and medical therapy with ... | [
"DB01200"
] |
MH_train_275 | MH_train_275 | MH_train_275 | interacts_with DB00005? | multiple_choice | [
"DB00459",
"DB00623",
"DB01259",
"DB01576",
"DB06212",
"DB06684",
"DB08877",
"DB08879",
"DB09068"
] | The effect of etanercept on cardiac transplant recipients : a study of TNFalpha antagonism and cardiac allograft hypertrophy . Cardiac allograft hypertrophy is associated with persistent expression of cardiac tumor necrosis factor ( P01375 ) -alpha . We investigated whether TNFalpha antagonism would impact allograft hy... | [
"DB08879"
] |
MH_train_276 | MH_train_276 | MH_train_276 | interacts_with DB01233? | multiple_choice | [
"DB00207",
"DB00317",
"DB00677",
"DB01238",
"DB01406",
"DB01418",
"DB06271",
"DB06779",
"DB09053"
] | Effects of metoclopramide and tropisetron on aldosterone secretion possibly due to agonism and antagonism at the Q13639 receptor . OBJECTIVE : Part of the prokinetic activity of metoclopramide can possibly be ascribed to agonist activity at Q13639 receptors . The 5- Q9H205 antagonist tropisetron is thought to act as an... | [
"DB01238"
] |
MH_train_277 | MH_train_277 | MH_train_277 | interacts_with DB00181? | multiple_choice | [
"DB00191",
"DB00486",
"DB00668",
"DB00912",
"DB00946",
"DB00991",
"DB01037",
"DB01211",
"DB06616"
] | [ Differential gene expression in nasopharyngeal carcinoma cell with reduced and normal expression of 6A8 alpha-mannosidase ] . OBJECTIVE : To detect the differential display of mRNA expression between human nasopharyngeal carcinoma cell CNE-2L2 with reduced malignancy caused by transduction of a DNA antisense to 6A8 a... | [
"DB00486"
] |
MH_train_278 | MH_train_278 | MH_train_278 | interacts_with DB06698? | multiple_choice | [
"DB00333",
"DB00603",
"DB00784",
"DB01128",
"DB01171",
"DB01356",
"DB01393",
"DB01590",
"DB04868"
] | P03372 -immunoreactive neurons contain calcitonin gene-related peptide , methionine-enkephalin or tyrosine hydroxylase in the female rat preoptic area . We have shown in our previous studies that estrogen treatment selectively influences calcitonin gene-related peptide ( P80511 ) - , methionine-enkephalin ( DB00134 -En... | [
"DB01171"
] |
MH_train_279 | MH_train_279 | MH_train_279 | interacts_with DB00519? | multiple_choice | [
"DB00290",
"DB00322",
"DB00379",
"DB00452",
"DB00472",
"DB01039",
"DB01120",
"DB05039",
"DB06287"
] | Functional characterisation of a novel mutation affecting the catalytic domain of P08253 in siblings with multicentric osteolysis , nodulosis and arthropathy . Multicentric osteolysis , nodulosis and arthropathy ( MONA ) is a rare autosomal recessive disorder . To date , 13 mutations of the matrix metalloproteinase 2 (... | [
"DB06287"
] |
MH_train_280 | MH_train_280 | MH_train_280 | interacts_with DB00814? | multiple_choice | [
"DB00035",
"DB00203",
"DB00215",
"DB00222",
"DB00341",
"DB00819",
"DB01151",
"DB01281",
"DB09048"
] | Dietary conjugated linoleic acid enhances spleen P37231 mRNA expression in broiler chicks . 1. The anti-inflammatory effects of dietary conjugated linoleic acid ( DB01211 ) on broilers repeatedly challenged with lipopolysaccharide ( LPS ) were investigated . 2 . Day-old broiler chicks were allotted into three treatment... | [
"DB00035"
] |
MH_train_281 | MH_train_281 | MH_train_281 | interacts_with DB06813? | multiple_choice | [
"DB00007",
"DB00031",
"DB00422",
"DB00712",
"DB00877",
"DB01238",
"DB04839",
"DB08827",
"DB08881"
] | Spline-fitting with a genetic algorithm : a method for developing classification structure-activity relationships . Classification methods allow for the development of structure-activity relationship models when the target property is categorical rather than continuous . We describe a classification method which fits d... | [
"DB00712"
] |
MH_train_282 | MH_train_282 | MH_train_282 | interacts_with DB00099? | multiple_choice | [
"DB00031",
"DB00290",
"DB00677",
"DB00758",
"DB01067",
"DB01114",
"DB01120",
"DB01128",
"DB04868"
] | Sulfonylureas inhibit cytokine-induced eosinophil survival and activation . Eosinophils play a key role in the pathogenesis of asthma and other allergic inflammatory diseases . We have previously shown that treatment of eosinophils with lidocaine preferentially inhibits P05113 -induced survival . This inhibition can no... | [
"DB00290"
] |
MH_train_283 | MH_train_283 | MH_train_283 | interacts_with DB01248? | multiple_choice | [
"DB00294",
"DB00502",
"DB00563",
"DB00605",
"DB00946",
"DB04905",
"DB06212",
"DB08816",
"DB08910"
] | Pharmacological approach to acute pancreatitis . The aim of the present review is to summarize the current knowledge regarding pharmacological prevention and treatment of acute pancreatitis ( AP ) based on experimental animal models and clinical trials . Somatostatin ( SS ) and octreotide inhibit the exocrine productio... | [
"DB04905"
] |
MH_train_284 | MH_train_284 | MH_train_284 | interacts_with DB08875? | multiple_choice | [
"DB00086",
"DB00391",
"DB00863",
"DB01211",
"DB06616",
"DB06684",
"DB06822",
"DB08877",
"DB08907"
] | Molecular targeted therapy in acute myeloid leukemia . The treatment of acute myeloid leukemia has not changed significantly over the last 40 years . Recent progress in understanding the biology of this disease and identification of driver mutations has ushered in a new era of molecular therapeutics . Although a number... | [
"DB01211"
] |
MH_train_285 | MH_train_285 | MH_train_285 | interacts_with DB00073? | multiple_choice | [
"DB00009",
"DB00233",
"DB00317",
"DB00477",
"DB00501",
"DB00630",
"DB00820",
"DB01281",
"DB01356"
] | [ Functional significance of P25942 and P29965 linking on human lung cells ] . OBJECTIVE : To determine the possible functional significance of P25942 and P29965 ( CD154 ) linking on human lung carcinomas and to assess the potential of P25942 as a therapeutic target . METHODS : We evaluated the effect of P29965 on the ... | [
"DB01281"
] |
MH_train_286 | MH_train_286 | MH_train_286 | interacts_with DB00928? | multiple_choice | [
"DB00072",
"DB00338",
"DB00622",
"DB00912",
"DB00988",
"DB01024",
"DB01285",
"DB05039",
"DB09053"
] | A new role for the P40763 inhibitor , Q9Y6X2 : a repressor of microphthalmia transcription factor . In vitro and in vivo evidence suggest that microphthalmia transcription factor ( O75030 ) plays a key regulatory role in tissue-specific gene regulation in several cell types , including melanocytes , osteoclasts , and m... | [
"DB00072"
] |
MH_train_287 | MH_train_287 | MH_train_287 | interacts_with DB00996? | multiple_choice | [
"DB00191",
"DB00316",
"DB00544",
"DB00707",
"DB00783",
"DB01076",
"DB01418",
"DB08827",
"DB09280"
] | Association analysis between 12 genetic variants of ten genes and personality traits in a young chinese Han population . Some genes involved in neurotransmission synthesis and transmission have been hypothesized to affect personality traits . To investigate the possible roles of these genes in personality traits of 16 ... | [
"DB00316"
] |
MH_train_288 | MH_train_288 | MH_train_288 | interacts_with DB00836? | multiple_choice | [
"DB00278",
"DB00623",
"DB00682",
"DB00951",
"DB00977",
"DB01151",
"DB01171",
"DB02546",
"DB09280"
] | Genetic factors influencing outcome from neurotrauma . PURPOSE OF REVIEW : Clinical outcome after neurotrauma is considerably variable and can only partly be explained by known prognostic factors . There is converging evidence from genetic research that a number of genetic variants may contribute to this variability . ... | [
"DB09280"
] |
MH_train_289 | MH_train_289 | MH_train_289 | interacts_with DB00065? | multiple_choice | [
"DB00104",
"DB00207",
"DB00351",
"DB00382",
"DB00452",
"DB00619",
"DB00909",
"DB01050",
"DB04908"
] | Does anti- P01375 therapy reduce the requirement for surgery in ulcerative colitis ? A systematic review . DB00065 has demonstrated its efficacy in moderate to severe ulcerative colitis . The Active Ulcerative Colitis Trial ( ACT ) -1 and 2 have demonstrated the beneficial impact of infliximab on the short-term colecto... | [
"DB01050"
] |
MH_train_290 | MH_train_290 | MH_train_290 | interacts_with DB05773? | multiple_choice | [
"DB00379",
"DB00459",
"DB00486",
"DB00495",
"DB01109",
"DB01393",
"DB06144",
"DB06643",
"DB08899"
] | Gating properties of Q14524 mutations and the response to mexiletine in long-QT syndrome type 3 patients . BACKGROUND : DB00379 ( Mex ) has been proposed as a gene-specific therapy for patients with long-QT syndrome type 3 ( LQT3 ) caused by mutations in the cardiac sodium channel gene ( Q14524 ) . The degree of QT sho... | [
"DB06643"
] |
MH_train_291 | MH_train_291 | MH_train_291 | interacts_with DB06148? | multiple_choice | [
"DB00035",
"DB00603",
"DB01032",
"DB01037",
"DB01200",
"DB01576",
"DB03880",
"DB04946",
"DB06779"
] | Proopiomelanocortin but not vasopressin or renin-angiotensin system induces resuscitative effects of central P08908 activation in haemorrhagic shock in rats . The aim of this study was to determine the effectory mechanisms : vasopressin , renin-angiotensin system and proopiomelanocortin-derived peptides ( P01189 ) , pa... | [
"DB01037"
] |
MH_train_292 | MH_train_292 | MH_train_292 | interacts_with DB01194? | multiple_choice | [
"DB00293",
"DB00341",
"DB00588",
"DB00668",
"DB00755",
"DB00762",
"DB01211",
"DB01296",
"DB04871"
] | TSII toxin isolated from Tityus serrulatus scorpion venom : behavioral , electroencephalographic , and histopathologic studies . We have reported earlier that intrahippocampal administration of the C-pool from Tityus serrulatus scorpion venom induces convulsions in rats . Here we report the effects of seven toxins isol... | [
"DB01211"
] |
MH_train_293 | MH_train_293 | MH_train_293 | interacts_with DB01409? | multiple_choice | [
"DB00215",
"DB00266",
"DB00333",
"DB00461",
"DB00734",
"DB01267",
"DB02901",
"DB08820",
"DB09026"
] | Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population . DB00734 non-compliance is often high due to undesirable side effects , whose development is in part genetically determined . Studies with genetic variants involved in the pharmacokinetics and pharmacodynamics ... | [
"DB00734"
] |
MH_train_294 | MH_train_294 | MH_train_294 | interacts_with DB01101? | multiple_choice | [
"DB00313",
"DB00472",
"DB00784",
"DB00834",
"DB01590",
"DB01656",
"DB06271",
"DB06589",
"DB08815"
] | Targeting Q01196 / Q06455 -histone deacetylase repressor complex : a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in Q01196 / Q06455 -positive acute myeloid leukemia cells . In t(8;21) acute myeloid leukemia ( AML ) , the Q01196 / Q06455 fusion protein promotes leukemogenesis ... | [
"DB01656"
] |
MH_train_295 | MH_train_295 | MH_train_295 | interacts_with DB06825? | multiple_choice | [
"DB00294",
"DB01016",
"DB01095",
"DB01098",
"DB01259",
"DB01406",
"DB06209",
"DB09068",
"DB09073"
] | A P04035 inhibitor possesses a potent anti-atherosclerotic effect other than serum lipid lowering effects -- the relevance of endothelial nitric oxide synthase and superoxide anion scavenging action . We have determined whether the anti-atherosclerotic effect of a 3-hydroxy-3-methyl-glutaryl- DB01992 ( HMG- DB01992 ) r... | [
"DB01016"
] |
MH_train_296 | MH_train_296 | MH_train_296 | interacts_with DB04845? | multiple_choice | [
"DB00175",
"DB00184",
"DB00222",
"DB00227",
"DB00834",
"DB00850",
"DB01030",
"DB01197",
"DB04844"
] | Implantation of P15692 transfected preadipocytes improves vascularization of fibrin implants on the cylinder chorioallantoic membrane ( P62158 ) model . The successful substitution or augmentation of soft tissues by implantation of three dimensional cell constructs , consisting of human preadipocytes and fibrin glue as... | [
"DB00834"
] |
MH_train_297 | MH_train_297 | MH_train_297 | interacts_with DB00112? | multiple_choice | [
"DB00227",
"DB00422",
"DB00452",
"DB00559",
"DB00904",
"DB00991",
"DB01182",
"DB06287",
"DB08879"
] | DB00112 ( avastin ) in ocular processes other than choroidal neovascularization . DB00112 is a full-length humanized murine monoclonal anti- P15692 ( vascular endothelial growth factor ) IgG1 antibody that was approved by the U.S . Food and Drug Administration in 2004 for the treatment of metastatic colorectal cancer .... | [
"DB08879"
] |
MH_train_298 | MH_train_298 | MH_train_298 | interacts_with DB00987? | multiple_choice | [
"DB00015",
"DB00514",
"DB00741",
"DB00850",
"DB00864",
"DB00909",
"DB00989",
"DB01296",
"DB04839"
] | Effects of DNA polymerase inhibitors on replicative and repair DNA synthesis in ultraviolet-irradiated HeLa cells . Aphidicolin specifically inhibits eukaryotic DNA polymerase alpha , while 2',3'-dideoxythymidine 5'-triphosphate ( d2TTP ) inhibits P06746 and gamma but not alpha . DB00987 5'-triphosphate ( araCTP ) inhi... | [
"DB00864"
] |
MH_train_299 | MH_train_299 | MH_train_299 | interacts_with DB00952? | multiple_choice | [
"DB00009",
"DB00072",
"DB00175",
"DB00222",
"DB00486",
"DB00514",
"DB00904",
"DB00946",
"DB01109"
] | Regulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis . Implications for the neurobiology of suicide . Disturbances in the serotonin ( 5-HT ) system is the neurobiological abnormality most consistently associated with suicide . Hyperactivity of the hypothalamic-pituitary-adrenal ( Q9Y251 ) axis is al... | [
"DB00904"
] |
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