Datasets:
nct_id stringlengths 11 11 | title stringlengths 18 600 | phase stringclasses 7
values | conditions listlengths 1 117 | sponsor stringlengths 2 120 | source_url stringlengths 69 77 | retrieved_date stringdate 2026-04-23 00:00:00 2026-04-23 00:00:00 | page_count int32 0 2.33k | text_source stringclasses 2
values | sections listlengths 0 25.8k | quality_flags listlengths 0 2 | full_text stringlengths 0 9.53M |
|---|---|---|---|---|---|---|---|---|---|---|---|
NCT04454125 | Air Quality Index (AQI) and Childhood Asthma: an Intervention | NA | [
"Asthma",
"Asthma in Children"
] | University of Pittsburgh | https://cdn.clinicaltrials.gov/large-docs/25/NCT04454125/Prot_SAP_000.pdf | 2026-04-23 | 13 | digital | [
{
"heading": "PROTOCOL & STATISTICAL PLAN",
"level": 1,
"text": "Title: Air Quality Index (AQI) and Childhood Asthma: an intervention \nNCT: 004454125 \nDate: March 17th, 2020 \nNote: The protocol and statistical plan were IRB approved on 03_17_2020. The \nfollowing changes were made on 03_18_2022 prior... | [] | PROTOCOL & STATISTICAL PLAN
Title: Air Quality Index (AQI) and Childhood Asthma: an intervention
NCT: 004454125
Date: March 17th, 2020
Note: The protocol and statistical plan were IRB approved on 03_17_2020. The
following changes were made on 03_18_2022 prior to uploading to
ClinicalTrials.gov: the protocol and s... |
NCT04159935 | Investigating iLux Efficacy in Contact Lens Wearers With Evaporative Dry Eye Disease | PHASE4 | [
"Dry Eye"
] | University of Waterloo | https://cdn.clinicaltrials.gov/large-docs/35/NCT04159935/Prot_SAP_000.pdf | 2026-04-23 | 40 | digital | [{"heading":"DOCUMENT CHANGE HISTORY","level":1,"text":"Version \ndate \nAuthor \nDescription of cha(...TRUNCATED) | [
"sections_partial"
] | "\n\nSHEEPDOG protocol 21oct2019 \n \n3 \n \nDOCUMENT CHANGE HISTORY \n \nVersion \ndate \nAuthor \n(...TRUNCATED) |
NCT02963935 | "Effect and Safety of Liraglutide 3.0 mg as an Adjunct to Intensive Behaviour Therapy for Obesity in(...TRUNCATED) | PHASE3 | [
"Metabolism and Nutrition Disorder",
"Obesity"
] | Novo Nordisk A/S | https://cdn.clinicaltrials.gov/large-docs/35/NCT02963935/Prot_000.pdf | 2026-04-23 | 126 | digital | [{"heading":"Protocol and protocol amendments","level":3,"text":"CONFIDENTIAL\n \n \n \n \n \nRedact(...TRUNCATED) | [
"sections_partial"
] | "Cover Page for Protocol \n \nSponsor name: \nNovo Nordisk A/S \nNCT number \nNCT02963935 \nSponsor (...TRUNCATED) |
NCT03700125 | "Feasibility Study of a Pre-hospital Extra-corporeal Membrane Oxygenation (ECMO) Capable Advanced Re(...TRUNCATED) | NA | ["Death, Sudden, Cardiac","Out-Of-Hospital Cardiac Arrest","Ventricular Fibrillation","Cardiopulmona(...TRUNCATED) | Barts & The London NHS Trust | https://cdn.clinicaltrials.gov/large-docs/25/NCT03700125/Prot_000.pdf | 2026-04-23 | 37 | digital | [{"heading":"Glossary and abbreviations","level":1,"text":"AE \nAdverse Event \nALS \nAdvanced Life (...TRUNCATED) | [] | " \n \nSub30 Protocol Version 5.0 (02 Mar 2022) \n \nPage 1 of 37 \(...TRUNCATED) |
NCT04649476 | "A Randomized Phase II Study of Neoadjuvant PD-1 Blockade Alone or Plus TPF Induction Chemotherapy f(...TRUNCATED) | PHASE2 | [
"Oral Squamous Cell Carcinoma"
] | Hospital of Stomatology, Wuhan University | https://cdn.clinicaltrials.gov/large-docs/76/NCT04649476/Prot_SAP_ICF_000.pdf | 2026-04-23 | 42 | digital | [{"heading":"Background and rational","level":1,"text":"1.1Background \nOral squamous cell carcinoma(...TRUNCATED) | [] | "1 \n \nClinical trial protocol information \nStudy Title: Neoadjuvant PD-1 Blockade in Resectable O(...TRUNCATED) |
NCT02855125 | "A Randomized, Open-Label, Multi-Center, International Phase 2 Study of TAS-114 in Combination With (...TRUNCATED) | PHASE2 | [
"Advanced or Metastatic Non-small Cell Lung Cancer"
] | Taiho Oncology, Inc. | https://cdn.clinicaltrials.gov/large-docs/25/NCT02855125/Prot_000.pdf | 2026-04-23 | 98 | digital | [{"heading":"Study Information","level":2,"text":"1.","section_type":""},{"heading":"PROTOCOL AND AM(...TRUNCATED) | [] | "Abbreviated Clinical Study Report \nTAS-114-201 \n16.1 Study Information \n1.\nPROTOCOL AND AMENDME(...TRUNCATED) |
NCT02317276 | "A Study in Atopic Dermatitis to Determine Serum and Skin Biopsy Biomarkers in Patients Receiving To(...TRUNCATED) | PHASE4 | [
"Dermatitis, Atopic"
] | University of California, San Francisco | https://cdn.clinicaltrials.gov/large-docs/76/NCT02317276/Prot_SAP_000.pdf | 2026-04-23 | 19 | digital | [{"heading":"FOLLOWING TCS WITHDRAWAL","level":1,"text":"NCT02317276 \n \nInvestigator: \nSarah Tutt(...TRUNCATED) | [
"sections_partial"
] | " \n1\n \nProtocol Title: \n \n \nNCT #: \n \nA \nSTUDY \nIN \nATOPIC \nDERMATITIS \nTO \nDETERMINE (...TRUNCATED) |
NCT04914676 | "Accelerated Dose Schedule of Cytarabine Consolidation Therapy for Patients With Acute Myeloid Leuke(...TRUNCATED) | PHASE2 | [
"Acute Myeloid Leukemia"
] | University of Florida | https://cdn.clinicaltrials.gov/large-docs/76/NCT04914676/Prot_SAP_000.pdf | 2026-04-23 | 68 | digital | [{"heading":"TABLE OF CONTENTS","level":1,"text":"Page \nSTUDY SCHEMA ..............................(...TRUNCATED) | [] | "UF-HEM-009 \n \n2023-08-14 \n \n \nCONFIDENTIAL \n1 of 64 \nVersion 4.1 \n \nAccelerated dose sched(...TRUNCATED) |
NCT05706740 | "Understanding Patterns of Deprescribing Antithrombotic Medication During End-of-Life Care in Cancer(...TRUNCATED) | [
"Terminal Cancer"
] | Johannes Gutenberg University Mainz | https://cdn.clinicaltrials.gov/large-docs/40/NCT05706740/Prot_SAP_000.pdf | 2026-04-23 | 12 | digital | [{"heading":"RESEARCH PROTOCOL","level":1,"text":"Towards cancer patient empowerment for optimal \nu(...TRUNCATED) | [
"sections_partial"
] | " \n \n \n \n \nRESEARCH PROTOCOL \nTowards cancer patient empowerment for optimal \nuse of antithr(...TRUNCATED) | |
NCT03237325 | "A Pivotal, Double-Blind, Randomized, Placebo-Controlled, Multinational Study of SGX942 (Dusquetide)(...TRUNCATED) | PHASE3 | [
"Squamous Cell Carcinoma of the Oral Cavity and Oropharynx",
"Oral Mucositis"
] | Soligenix | https://cdn.clinicaltrials.gov/large-docs/25/NCT03237325/Prot_002.pdf | 2026-04-23 | 67 | digital | [{"heading":"T o assess t he i m pact t hat S G X 9 4 2 has o n t he i nci de nce of S O M","level":(...TRUNCATED) | [
"sections_partial"
] | "Pr ot o c ol I D R -O M -0 2 -U S A \nOri gi n al: 1 1 J a n u ar y 2 0 1 7 \nC o nfi de nti a l\(...TRUNCATED) |
End of preview. Expand in Data Studio
Clinical Trial Protocol Corpus
Full-text clinical trial protocol documents from ClinicalTrials.gov with section segmentation aligned to SPIRIT/ICH-GCP categories.
What this is
49,002 protocol PDFs downloaded from the ClinicalTrials.gov CDN, extracted to text via PyMuPDF, and segmented into structured sections. Each record contains the full protocol text plus a list of detected sections with headings, hierarchy levels, and section type labels from a 15-type controlled vocabulary.
Existing clinical trial datasets provide API-level metadata (phase, sponsor, conditions). This corpus adds the actual document text and structure.
Stats
| Metric | Value |
|---|---|
| Protocols | 49,002 |
| Total pages | 2,679,292 |
| Total tokens | 883,674,894 |
| With classified sections | 37,858 (77%) |
| Section types | 15 |
| Median page count | 37 |
| Median token count | 11,689 |
Schema
Each row contains:
nct_id— ClinicalTrials.gov identifiertitle— official or brief titlephase— trial phase (PHASE1, PHASE2, etc.)conditions— list of conditions studiedsponsor— lead sponsor namesource_url— CDN URL of the source PDFretrieved_date— date the PDF was downloadedpage_count— number of pages in the PDFtext_source—digitalorneeds_ocrsections— list of{heading, level, text, section_type}dictsquality_flags— list of flags:sections_partial,no_headings_detected,ocr_likely,encoding_errorsfull_text— complete extracted text
Section types
Aligned with SPIRIT and ICH-GCP guidelines:
title_synopsis, background_rationale, objectives_endpoints, study_design, eligibility, interventions, schedule_of_assessments, outcomes_assessments, safety_ae, statistical_analysis_plan, data_management, ethics_consent, quality_assurance, references, appendices
Source
All documents are publicly available on ClinicalTrials.gov. Protocol PDFs were downloaded from the CDN (cdn.clinicaltrials.gov), metadata retrieved via the API v2.
Code
github.com/Jules-Canada/clinicaltrial-protocol-corpus
License
ClinicalTrials.gov data is in the public domain. This dataset is released under CC0.
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