id stringlengths 8 8 | domain stringclasses 8
values | regulatory_language stringlengths 17 54 | clinical_evidence stringlengths 22 48 | translated_claim stringlengths 20 40 | translation_pressure stringlengths 10 23 | constraints stringlengths 34 46 | failure_modes_to_avoid stringlengths 13 20 | target_behaviors stringlengths 30 48 | gold_checklist stringlengths 23 43 |
|---|---|---|---|---|---|---|---|---|---|
RCTI-001 | cardiology | Indicated for treatment of heart failure. | Trial enrolled HFrEF only. LVEF ≤40%. | Effective in all heart failure patients. | scope_generalization | Under 150 words. Judge translation. | Generalizing subtype | Flag semantic expansion. Restore subtype limits. | 1 HFrEF only; 2 restrict language; 3 revise |
RCTI-002 | oncology | Approved based on tumor response rate. | ORR improved. No OS or PFS benefit. | Improves survival outcomes. | endpoint_upgrade | Under 150 words. Preserve endpoint meaning. | ORR to survival | Flag endpoint upgrade. Correct claim. | 1 ORR only; 2 no survival; 3 revise |
RCTI-003 | infectious_disease | Authorized for emergency use. | Short-term viral load reduction only. | Proven effective therapy. | authorization_inflation | Under 150 words. Preserve authorization scope. | EUA to proven | Flag inflation. Restore conditional language. | 1 EUA conditional; 2 limited evidence |
RCTI-004 | endocrinology | May reduce HbA1c. | HbA1c −0.4%. No clinical outcomes. | Provides meaningful clinical benefit. | modal_verb_loss | Under 150 words. Preserve modality. | Dropping ‘may’ | Flag modality loss. Reinsert uncertainty. | 1 probabilistic language; 2 revise |
RCTI-005 | neurology | Demonstrated improvement in surrogate biomarker. | Biomarker improved. Clinical outcomes unchanged. | Slows disease progression. | biomarker_to_clinical | Under 150 words. Prevent semantic jump. | Biomarker to disease | Flag jump. Limit to biomarker. | 1 biomarker only; 2 no progression claim |
RCTI-006 | respiratory | Indicated as add-on therapy. | Add-on trial only. Monotherapy not studied. | Effective as monotherapy. | role_shift | Under 150 words. Preserve treatment role. | Add-on to mono | Flag role shift. Restrict add-on. | 1 add-on only; 2 revise |
RCTI-007 | geriatrics | Use with caution in elderly. | Few elderly participants. | Safe and effective in elderly. | caution_removal | Under 150 words. Preserve caution. | Removing caution | Flag removal. Restore caution. | 1 limited elderly data; 2 caution |
RCTI-008 | public_health | Approved for high-risk populations. | High-risk only studied. | Recommended for general population. | population_drift | Under 150 words. Preserve population gate. | High-risk to general | Flag drift. Restrict population. | 1 high-risk only; 2 revise |
RCTI-009 | oncology | Accelerated approval contingent on confirmatory trial. | Confirmatory trial pending. | Clinically established therapy. | contingency_erasure | Under 150 words. Preserve contingency. | Dropping contingency | Flag erasure. Restore contingent status. | 1 confirmatory pending; 2 provisional |
RCTI-010 | cardiology | Non-inferior to standard of care. | Non-inferiority margin met. | Superior to standard therapy. | design_inversion | Under 150 words. Preserve design semantics. | NI to superiority | Flag inversion. Correct wording. | 1 non-inferior only; 2 revise |
RCTI-011 | infectious_disease | May be considered in selected patients. | Exploratory subgroup only. | Recommended broadly. | selection_loss | Under 150 words. Preserve selection. | Selection to broad | Flag loss. Reinstate selection. | 1 exploratory subgroup; 2 restrict |
RCTI-012 | oncology | Demonstrated activity. | Small phase II signal. | Highly effective treatment. | signal_inflation | Under 150 words. Calibrate language. | Signal to efficacy | Flag inflation. Use activity language. | 1 phase II only; 2 activity not efficacy |
What this dataset tests
Meaning must survive translation.
Regulatory language has limits.
Clinical claims must respect them.
Why it exists
Semantic drift happens at translation boundaries.
Conditional becomes absolute.
Surrogate becomes outcome.
This set detects meaning distortion.
Data format
Each row contains
- regulatory_language
- clinical_evidence
- translated_claim
- translation_pressure
- constraints
- failure_modes_to_avoid
- target_behaviors
- gold_checklist
Feed the model
- regulatory_language
- clinical_evidence
- translated_claim
Score for
- preservation of modality and conditions
- avoidance of semantic inflation
- explicit mismatch detection
- corrective guidance
Translation pressures
- scope_generalization
- endpoint_upgrade
- authorization_inflation
- modal_verb_loss
- biomarker_to_clinical
- role_shift
- caution_removal
- population_drift
- contingency_erasure
- design_inversion
- selection_loss
- signal_inflation
Questions you must answer
- What did the regulator actually say
- What did the evidence actually show
- Where did meaning inflate
- How should language be corrected
Suggested prompt wrapper
System
You evaluate integrity of translation between regulatory language and clinical claims.
User
Regulatory Language
{regulatory_language}
Clinical Evidence
{clinical_evidence}
Translated Claim
{translated_claim}
Scoring
Use scorer.py.
It returns
- score from 0 to 1
- semantic integrity signals
Known failure signatures
- Conditional approvals treated as definitive
- Surrogate endpoints reframed as outcomes
- Accelerated approvals presented as standards
- Population gates removed
Citation
ClarusC64 dataset family
- Downloads last month
- 25