id stringclasses 6
values | condition_family stringclasses 6
values | medication_set stringclasses 6
values | baseline_coherence_metrics stringclasses 6
values | post_combination_coherence_metrics stringclasses 6
values | variance_shift stringclasses 3
values | synchrony_shift stringclasses 3
values | net_coherence_score stringclasses 3
values | interpretation stringclasses 6
values | notes stringclasses 6
values | constraints stringclasses 1
value | gold_checklist stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|
CCP-001 | diabetes | metformin + GLP1 | High glucose variance; low activity鈥搒leep coupling | Lower glucose variance; improved sleep鈥揳ctivity coupling | Decrease | Increase | High | System-wide coherence gain | Upstream appetite and insulin effects align | Under 220 words. | baseline+post+score |
CCP-002 | heart_failure | ACEi + beta-blocker + diuretic | BP variability; exertional intolerance | BP stabilized; functional tolerance improved | Decrease | Increase | High | Coherent combination | Classic guideline synergy | Under 220 words. | baseline+post+score |
CCP-003 | autoimmune | steroid + NSAID | Low symptom score; high lab volatility | Symptoms quiet; lab variance increases | Increase | Decrease | Low | Cosmetic suppression | Fragility masked | Under 220 words. | baseline+post+score |
CCP-004 | psychiatric | SSRI + benzodiazepine | Anxiety spikes; sleep fragmented | Anxiety lower; sleep fragmented persists | Neutral | Neutral | Medium | Partial coherence | Symptom relief without system alignment | Under 220 words. | baseline+post+score |
CCP-005 | respiratory | ICS + LABA | Frequent wheeze; eosinophils high | Wheeze reduced; eosinophils lower | Decrease | Increase | High | Coherent airway control | Aligned inflammatory and functional effects | Under 220 words. | baseline+post+score |
CCP-006 | cardiac | antiarrhythmic + stimulant | HR variability unstable | Arrhythmia suppressed; autonomic volatility rises | Increase | Decrease | Low | Hidden antagonism | Control with systemic cost | Under 220 words. | baseline+post+score |
What this dataset tests
Whether a drug combination
improves system-wide coherence
or merely suppresses symptoms.
Required outputs
- baseline coherence metrics
- post-combination coherence metrics
- variance and synchrony shifts
- net coherence score
- interpretation
Use case
Front layer of the Polypharmacy Coherence Matrix.
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