"""
Optional peptide UI helpers: 3D approximation (py3Dmol), known-AMP similarity, residue highlighting.

Does not modify model loading or prediction logic.
"""
from __future__ import annotations

import csv
import math
import pathlib
from typing import List, Optional, Tuple, Any

import numpy as np

# Fallback if `Data/ampData.csv` is missing (e.g. local dev without Data/).
_FALLBACK_KNOWN_AMPS: Tuple[str, ...] = (
    "KWKLFKKIGAVLKVL",
    "GIGKFLHSAKKFGKAFVGEIMNS",
    "LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLV",
    "KLFKKILKYL",
    "FLPLLAGLAANFLPKIFCKITRKC",
)


def _amp_data_csv_path() -> pathlib.Path:
    # StreamlitApp/utils/peptide_extras.py -> repo root is parents[2]
    return pathlib.Path(__file__).resolve().parents[2] / "Data" / "ampData.csv"


def _load_known_amps_from_csv() -> List[str]:
    """
    Load unique sequences labeled as AMP (label == 1) from Data/ampData.csv.
    Sequences are uppercased for consistent similarity matching.
    """
    path = _amp_data_csv_path()
    if not path.exists():
        return list(_FALLBACK_KNOWN_AMPS)

    seen: set[str] = set()
    amps: List[str] = []
    try:
        with path.open(newline="", encoding="utf-8") as f:
            reader = csv.DictReader(f)
            if not reader.fieldnames or "sequence" not in reader.fieldnames:
                return list(_FALLBACK_KNOWN_AMPS)
            for row in reader:
                label = str(row.get("label", "")).strip()
                if label != "1":
                    continue
                raw = (row.get("sequence") or "").strip()
                if not raw:
                    continue
                seq = raw.upper()
                if seq in seen:
                    continue
                seen.add(seq)
                amps.append(seq)
    except Exception:
        return list(_FALLBACK_KNOWN_AMPS)

    return amps if amps else list(_FALLBACK_KNOWN_AMPS)


# Known AMP pool for similarity search (from ampData.csv label=1, or fallback list).
KNOWN_AMPS: List[str] = _load_known_amps_from_csv()

# py3Dmol viewer: skip very long sequences (labels + sticks scale with length).
MAX_3D_SEQUENCE_LENGTH: int = 60

STRUCTURE_3D_LEGEND_MARKDOWN: str = """
**Color legend**
- **Blue:** Positively charged residues (K, R, H)  
- **Red:** Negatively charged residues (D, E)  
- **Green:** Hydrophobic residues (A, V, I, L, M, F, W, Y)  
- **Gray:** Other / polar or unclassified residues  
"""

STRUCTURE_3D_INTERPRETATION_MARKDOWN: str = """
**Structural interpretation (approximation only)**

This is a **simplified helical CA trace** used to visualize how residue chemistry is arranged in 3D space — **not** an experimentally determined fold.

- **Clusters of green** often correspond to membrane-facing / hydrophobic patches.  
- **Blue regions** highlight cationic residues that can promote binding to anionic bacterial surfaces.  
- **Spatial separation** between hydrophobic and charged segments can suggest **amphipathic** character, common among many AMPs.  

Together, these cues help discuss whether a sequence has motifs frequently associated with antimicrobial peptides — **wet-lab validation is still required**.
"""

# One-letter -> three-letter (for minimal PDB lines for py3Dmol).
_ONE_TO_THREE = {
    "A": "ALA",
    "R": "ARG",
    "N": "ASN",
    "D": "ASP",
    "C": "CYS",
    "Q": "GLN",
    "E": "GLU",
    "G": "GLY",
    "H": "HIS",
    "I": "ILE",
    "L": "LEU",
    "K": "LYS",
    "M": "MET",
    "F": "PHE",
    "P": "PRO",
    "S": "SER",
    "T": "THR",
    "W": "TRP",
    "Y": "TYR",
    "V": "VAL",
}


def sequence_similarity(seq1: str, seq2: str) -> float:
    """Position-wise match rate normalized by max length (as specified)."""
    if not seq1 or not seq2:
        return 0.0
    matches = sum(1 for a, b in zip(seq1, seq2) if a == b)
    return matches / max(len(seq1), len(seq2))


def find_most_similar(sequence: str) -> Tuple[Optional[str], float]:
    if not sequence or not KNOWN_AMPS:
        return None, 0.0
    seq = "".join(c for c in sequence.upper() if not c.isspace())
    if not seq:
        return None, 0.0
    best_seq = KNOWN_AMPS[0]
    best_score = sequence_similarity(seq, KNOWN_AMPS[0])
    for amp in KNOWN_AMPS[1:]:
        score = sequence_similarity(seq, amp)
        if score > best_score:
            best_score = score
            best_seq = amp
    return best_seq, best_score


def get_residue_color(aa: str) -> str:
    """Map one-letter residue to a py3Dmol color name (single-letter, uppercased)."""
    ch = aa.upper() if aa else ""
    positive = ["K", "R", "H"]
    negative = ["D", "E"]
    hydrophobic = ["A", "V", "I", "L", "M", "F", "W", "Y"]
    if ch in positive:
        return "blue"
    if ch in negative:
        return "red"
    if ch in hydrophobic:
        return "green"
    return "gray"


def residue_color_mpl(aa: str) -> str:
    """Matplotlib-compatible hex colors matching `get_residue_color` categories (high-contrast for plots)."""
    cat = get_residue_color(aa)
    return {
        "blue": "#1D4ED8",
        "red": "#DC2626",
        "green": "#16A34A",
        "gray": "#57534E",
    }.get(cat, "#57534E")


HELIX_WHEEL_LEGEND_MARKDOWN: str = """
**Helical wheel readout**
- **Blue wedge:** cationic (K, R, H) — often important for initial membrane association.  
- **Red wedge:** anionic (D, E).  
- **Green wedge:** hydrophobic — often grouped on one face in amphipathic helices (membrane-facing).  
- **Gray:** polar / other — may participate in solubility or hydrogen bonding.  

Residues are placed using a **100° step** per position (common α-helical wheel convention). This is a **2D projection**, not a solved 3D structure.
"""

# Short blurbs for compact UI expanders (Visualize Peptide page)
COMPACT_3D_LEGEND: str = """
**How to read this 3D view**
- **Blue:** positively charged residues (K, R, H)
- **Red:** negatively charged residues (D, E)
- **Green:** hydrophobic residues (A, V, I, L, M, F, W, Y)
- **Gray:** other / polar residues
- Backbone is a **helix-like approximation**, not an experimental structure.
"""
COMPACT_WHEEL_LEGEND: str = """
**How to read this helical wheel**
- **Radial spokes:** residue positions around the helix (100 degrees per residue)
- **Black connectors:** sequence order (`i -> i+1`) across the wheel
- **Colored circles:** residue chemistry classes
- Color mapping matches the 3D view (**blue / red / green / gray**)
"""
COMPACT_MAP_LEGEND: str = """
**How to read this sequence map**
- Uses the same residue color mapping as 3D and helical wheel
- Highlights where charged vs hydrophobic residues cluster along the sequence
- Useful for quick amphipathic pattern checks
"""


def plot_helical_wheel(sequence: str, figsize: Tuple[float, float] = (6.2, 6.2)) -> Any:
    """
    Detailed helical wheel (matplotlib polar): radial spokes, sequence-order connectors (i→i+1),
    and colored residue disks — same chemistry classes as 3D / HTML maps (high-contrast colors).
    """
    import matplotlib.pyplot as plt
    from matplotlib import patheffects as pe

    clean = "".join(c for c in (sequence or "").upper() if not c.isspace())
    n = len(clean)
    fig, ax = plt.subplots(figsize=figsize, subplot_kw={"projection": "polar"})
    fig.patch.set_facecolor("white")
    if n == 0:
        ax.set_facecolor("#ffffff")
        ax.set_title("Helical wheel (empty sequence)", pad=12)
        return fig

    ax.set_facecolor("#ffffff")

    angles_deg = np.array([i * 100.0 for i in range(n)], dtype=float) % 360.0
    angles_rad = np.deg2rad(angles_deg)
    r_inner, r_ring = 0.06, 0.88
    fs = max(7, min(11, int(220 / max(n, 1))))
    pt_size = float(np.clip(8000.0 / max(n, 1), 130.0, 420.0))

    ax.set_theta_zero_location("N")
    ax.set_theta_direction(-1)

    # Radial spokes (residue positions)
    for i in range(n):
        th = angles_rad[i]
        ax.plot(
            [th, th],
            [r_inner, r_ring],
            color="#1a1a1a",
            linewidth=0.65,
            alpha=0.45,
            zorder=1,
        )

    # Sequence-order connections (straight chords in the plane — classic wheel “star”)
    for i in range(n - 1):
        ax.plot(
            [angles_rad[i], angles_rad[i + 1]],
            [r_ring, r_ring],
            color="#0a0a0a",
            linewidth=1.05,
            solid_capstyle="round",
            zorder=2,
        )

    colors = [residue_color_mpl(aa) for aa in clean]
    ax.scatter(
        angles_rad,
        np.full(n, r_ring),
        s=pt_size,
        c=colors,
        edgecolors="#111111",
        linewidths=1.2,
        zorder=4,
    )

    for i, aa in enumerate(clean):
        t = ax.text(
            angles_rad[i],
            r_ring,
            aa,
            ha="center",
            va="center",
            fontsize=fs,
            color="#0a0a0a",
            fontweight="bold",
            zorder=5,
        )
        t.set_path_effects([pe.withStroke(linewidth=2.2, foreground="white")])

    ax.set_ylim(0, 1.0)
    ax.set_yticklabels([])
    ax.set_xticklabels([])
    ax.grid(False)
    ax.set_title(
        "Helical wheel (α-helix, 100°/residue) — spokes + sequence connectors",
        pad=14,
        fontsize=11,
        color="#111111",
    )
    return fig


def get_residue_style(aa: str) -> str:
    """Inline styles for sequence map — colors aligned with wheel / 3D categories (high contrast)."""
    positive = ["K", "R", "H"]
    negative = ["D", "E"]
    hydrophobic = ["A", "V", "I", "L", "M", "F", "W", "Y"]
    if aa in positive:
        return "background-color: #1D4ED8; color: #ffffff; padding: 2px 3px; border-radius: 2px;"
    if aa in negative:
        return "background-color: #DC2626; color: #ffffff; padding: 2px 3px; border-radius: 2px;"
    if aa in hydrophobic:
        return "background-color: #16A34A; color: #ffffff; padding: 2px 3px; border-radius: 2px;"
    return "background-color: #57534E; color: #ffffff; padding: 2px 3px; border-radius: 2px;"


def build_importance_map_html(sequence: str) -> str:
    """Build HTML for residue importance highlighting (escape non-AA safely)."""
    import html as html_mod

    parts: List[str] = []
    for ch in sequence:
        if ch.isspace():
            continue
        aa = ch.upper()
        style = get_residue_style(aa)
        parts.append(f'<span style="{style}">{html_mod.escape(aa)}</span>')
    return "".join(parts)


def generate_helix_pdb(sequence: str, smooth: bool = False) -> str:
    """
    Generate a minimal PDB string (helix-like CA trace).
    When smooth=True, apply light coordinate smoothing for a softer backbone path.
    """
    pdb_lines: List[str] = []
    atom_index = 1
    clean = "".join(c for c in sequence.upper() if not c.isspace())
    n = len(clean)
    if n == 0:
        return ""

    theta_step = 100.0 * math.pi / 180.0  # ~α-helix angular step on the wheel
    rise = 1.45
    coords: List[Tuple[float, float, float]] = []
    for i in range(n):
        angle = i * theta_step
        r = 5.0 + 0.12 * math.sin(i * 0.4)
        x = math.cos(angle) * r
        y = math.sin(angle) * r
        z = i * rise
        coords.append((x, y, z))

    if smooth and n >= 3:
        xs = np.array([c[0] for c in coords], dtype=float)
        ys = np.array([c[1] for c in coords], dtype=float)
        zs = np.array([c[2] for c in coords], dtype=float)
        k = np.array([0.2, 0.6, 0.2])
        for _ in range(2):
            xs = np.convolve(xs, k, mode="same")
            ys = np.convolve(ys, k, mode="same")
            zs = np.convolve(zs, k, mode="same")
        xs[0], xs[-1] = coords[0][0], coords[-1][0]
        ys[0], ys[-1] = coords[0][1], coords[-1][1]
        zs[0], zs[-1] = coords[0][2], coords[-1][2]
        coords = list(zip(xs.tolist(), ys.tolist(), zs.tolist()))

    for i, aa in enumerate(clean):
        res_name = _ONE_TO_THREE.get(aa, "UNK")
        x, y, z = coords[i]
        res_num = i + 1
        pdb_lines.append(
            f"ATOM  {atom_index:5d}  CA  {res_name:3s} A{res_num:4d}    "
            f"{x:8.3f}{y:8.3f}{z:8.3f}  1.00  0.00           C"
        )
        atom_index += 1
    return "\n".join(pdb_lines)


def render_3d_structure(
    sequence: str,
    width: int = 500,
    height: int = 400,
    iframe_height: int = 420,
    *,
    enhanced: bool = False,
    spin: bool = False,
) -> bool:
    """
    Render py3Dmol view: gray stick backbone + colored spheres per residue (CA-only PDB).
    When enhanced=True: smoother helix path, slightly larger spheres, more labels.
    When spin=True: enable viewer spin (off by default).
    Not a real folded structure — helix-like CA trace only.
    """
    import streamlit.components.v1 as components

    clean = "".join(c for c in (sequence or "").upper() if not c.isspace())
    if not clean:
        return False
    if len(clean) > MAX_3D_SEQUENCE_LENGTH:
        return False
    try:
        import py3Dmol  # type: ignore
    except Exception:
        return False

    try:
        pdb_data = generate_helix_pdb(clean, smooth=enhanced)
        view = py3Dmol.view(width=width, height=height)
        view.addModel(pdb_data, "pdb")

        try:
            view.setBackgroundColor("#0f0f12" if enhanced else "#1e1e1e")
        except Exception:
            pass

        add_style = getattr(view, "addStyle", None)

        stick_radius = 0.14 if enhanced else 0.12
        sphere_radius = 0.48 if enhanced else 0.42
        try:
            view.setStyle({}, {"stick": {"radius": stick_radius, "color": "#9e9e9e"}})
        except Exception:
            pass

        for i, aa in enumerate(clean):
            color = get_residue_color(aa)
            sel = {"resi": i + 1}
            sphere_style = {"sphere": {"radius": sphere_radius, "color": color}}
            if callable(add_style):
                add_style(sel, sphere_style)
            else:
                view.setStyle(sel, sphere_style)

        if enhanced:
            try:
                if callable(add_style):
                    add_style({}, {"cartoon": {"color": "#dddddd", "opacity": 0.25}})
            except Exception:
                pass

        max_labels = 60 if enhanced else 40
        label_every = max(1, (len(clean) + max_labels - 1) // max_labels)
        fs = 10 if enhanced else 9
        for i, aa in enumerate(clean):
            if i % label_every != 0:
                continue
            try:
                view.addLabel(
                    aa,
                    {
                        "position": {"resi": i + 1, "atom": "CA"},
                        "backgroundColor": "#1a1a1a",
                        "fontColor": "#ffffff",
                        "fontSize": fs,
                    },
                )
            except Exception:
                pass

        view.zoomTo()

        if spin:
            try:
                view.spin(True)
            except Exception:
                try:
                    sp = getattr(view, "spin", None)
                    if callable(sp):
                        sp()
                except Exception:
                    pass

        if hasattr(view, "_make_html"):
            html = view._make_html()
        else:
            html = view.write()
        components.html(html, height=iframe_height)
        return True
    except Exception:
        return False