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A total of approximately 550 subjects will be","confidence":0.99853515625,"confidence_rate":0.9999859047370074},{"cnt":[[245,2131],[1884,2131],[1884,2179],[245,2179]],"region":{"top_left_x":244,"top_left_y":2131,"width":1641,"height":48},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cdbee85a7144c28a6a9059ed194d821","type":"text","conversion_output":true,"text":"randomized (until accrual of at least 275 participants on each treatment arm) during periods of","text_display":" randomized (until accrual of at least 275 participants on each treatment arm) during periods of","confidence":1,"confidence_rate":1},{"cnt":[[245,2176],[1313,2176],[1313,2224],[245,2224]],"region":{"top_left_x":244,"top_left_y":2176,"width":1069,"height":48},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69aef346ad224553929bcaead3cde937","type":"text","conversion_output":true,"text":"neutropenia associated with chemotherapy for the treatment of AML.","text_display":" neutropenia associated with chemotherapy for the treatment of AML.","confidence":1,"confidence_rate":1},{"cnt":[[245,2264],[1880,2264],[1880,2310],[245,2310]],"region":{"top_left_x":244,"top_left_y":2264,"width":1636,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"578bb97726cf4e65a0fe0430682f6687","type":"text","conversion_output":true,"text":"The frequency and severity of IFI in immunocompromised patients has increased steadily over the past","text_display":"\n\nThe frequency and severity of IFI in immunocompromised patients has increased steadily over the past","confidence":1,"confidence_rate":1},{"cnt":[[245,2307],[1880,2307],[1880,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2307,"width":1636,"height":50},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"811b356177574fe9916bac783ce8826b","type":"text","conversion_output":true,"text":"2 decades. \\({ }^{1-3}\\) The incidence of IFI as a cause of sepsis has more than tripled with 5,231 cases in 1979","text_display":" 2 decades. \\({ }^{1-3}\\) The incidence of IFI as a cause of sepsis has more than tripled with 5,231 cases in 1979","confidence":0.9785456513077975,"confidence_rate":0.9998130533486225},{"cnt":[[245,2350],[1880,2350],[1880,2398],[245,2398]],"region":{"top_left_x":244,"top_left_y":2350,"width":1636,"height":48},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"627fd923d3f147148ce0574eede00fbc","type":"text","conversion_output":true,"text":"compared with 16,042 cases in \\(2000 .^{4}\\) In children with fungal sepsis, the case fatality rate has been","text_display":" compared with 16,042 cases in \\(2000 .^{4}\\) In children with fungal sepsis, the case fatality rate has been","confidence":0.6635780187531282,"confidence_rate":0.9965305338645298},{"cnt":[[245,2393],[1878,2393],[1878,2443],[245,2443]],"region":{"top_left_x":244,"top_left_y":2393,"width":1634,"height":50},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7916c3ec12b04c9f8ca709bc79d6bad8","type":"text","conversion_output":true,"text":"estimated to be \\(13 \\% .^{5}\\) Among children with cancer, those undergoing hematopoietic stem cell","text_display":" estimated to be \\(13 \\% .^{5}\\) Among children with cancer, those undergoing hematopoietic stem cell","confidence":0.99755859375,"confidence_rate":0.9999767203534344},{"cnt":[[245,2441],[1880,2441],[1880,2486],[245,2486]],"region":{"top_left_x":244,"top_left_y":2440,"width":1636,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26a1caab5d9644479356b40eb0a1eb98","type":"text","conversion_output":true,"text":"transplantation (HSCT) and those receiving AML therapy are at highest risk for IFI. The most common","text_display":" transplantation (HSCT) and those receiving AML therapy are at highest risk for IFI. The most common","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[614,2582],[614,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":371,"height":42},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a26858b53c244122b853e0e944e8cb79","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1766,2582],[1880,2582],[1880,2628],[1766,2628]],"region":{"top_left_x":1766,"top_left_y":2582,"width":114,"height":46},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2b6cbaed6ed42e2a22df4d86abd2744","type":"page_info","conversion_output":false,"text":"Page 8","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"30d0fca4-08d7-48bb-b63f-1324b67d52fd-09","page":9,"lines":[{"cnt":[[262,88],[436,88],[436,122],[262,122]],"region":{"top_left_x":262,"top_left_y":88,"width":175,"height":35},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8167e45afc2e4f01876ceb4317483070","type":"page_info","conversion_output":false,"text":"CHILDREN'S","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,120],[415,120],[415,157],[262,157]],"region":{"top_left_x":262,"top_left_y":120,"width":153,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6fd14d98b8c341dc8c6c098a4fc04c71","type":"page_info","conversion_output":false,"text":"ONCOLOGY","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[494,131],[1493,131],[1493,170],[494,170]],"region":{"top_left_x":494,"top_left_y":131,"width":1000,"height":39},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5f507aed7cdb409ca8fce381909f92b6","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.6674760914652325,"confidence_rate":0.9949595993241329},{"cnt":[[1693,125],[1880,125],[1880,165],[1693,165]],"region":{"top_left_x":1692,"top_left_y":124,"width":188,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce81dea202414fcdbbf3b54003a7acc3","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[363,155],[363,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":102,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bcee191605ca4df69dabcab528bddd8a","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1403,249],[1403,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1159,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d2c069f6c314c6896975b85e6d8ecf0","type":"text","conversion_output":true,"text":"causes of IFI in children with cancer are Candida spp. and Aspergillus spp.","text_display":"\ncauses of IFI in children with cancer are Candida spp. and Aspergillus spp.","confidence":0.9970715045928955,"confidence_rate":0.9999633407739673},{"cnt":[[245,339],[1884,339],[1884,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1641,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"732e31ffb8f94ec39dca3c49fedcda47","type":"text","conversion_output":true,"text":"Candida spp. are commensal organisms that normally reside on mucosal and skin surfaces. The portal of","text_display":"\nCandida spp. are commensal organisms that normally reside on mucosal and skin surfaces. The portal of","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1880,382],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1636,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69b3a1a58122470db7f003123ba25671","type":"text","conversion_output":true,"text":"entry is typically the gut mucosa and less commonly the skin. Therefore, children undergoing intensive","text_display":" entry is typically the gut mucosa and less commonly the skin. Therefore, children undergoing intensive","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26e5b9b5ef744416a4a65085e25c2d4c","type":"text","conversion_output":true,"text":"therapy for cancer that results in mucositis are at high risk for infection with Candida spp. Although","text_display":" therapy for cancer that results in mucositis are at high risk for infection with Candida spp. Although","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1880,471],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1636,"height":48},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d41f65e5320d4c479d44c321b43b4c49","type":"text","conversion_output":true,"text":"mucosal candidal infections occur, candidemia is the most serious clinical syndrome caused by Candida","text_display":" mucosal candidal infections occur, candidemia is the most serious clinical syndrome caused by Candida","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1880,511],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1636,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a03f59d2614d48cb841508197ebde1a4","type":"text","conversion_output":true,"text":"spp. Its manifestations may include fever unresponsive to antibiotics, macronodular skin lesions,","text_display":" spp. Its manifestations may include fever unresponsive to antibiotics, macronodular skin lesions,","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5743b0b4d4734f7ea008e4b86b5c14ab","type":"text","conversion_output":true,"text":"myalgias, and sepsis. Acute hematogenous dissemination of Candida to 1 or more organs can occur","text_display":" myalgias, and sepsis. Acute hematogenous dissemination of Candida to 1 or more organs can occur","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1880,602],[1880,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1636,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbf59e1e176948e28fb616635b3bbc28","type":"text","conversion_output":true,"text":"including the heart, lung, brain, eye, kidney, liver and spleen. Immunocompromised children are at higher","text_display":" including the heart, lung, brain, eye, kidney, liver and spleen. Immunocompromised children are at higher","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1880,645],[1880,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1636,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6686471b2f9345169cd270d617b38142","type":"text","conversion_output":true,"text":"risk for disseminated disease. Disseminated infections are considered to be more severe and require","text_display":" risk for disseminated disease. Disseminated infections are considered to be more severe and require","confidence":1,"confidence_rate":1},{"cnt":[[245,690],[1880,690],[1880,737],[245,737]],"region":{"top_left_x":244,"top_left_y":689,"width":1636,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c13126f483c440fc8c6335ffa955c7a1","type":"text","conversion_output":true,"text":"longer courses of antifungal therapy. The attributable mortality of invasive candidiasis in children has","text_display":" longer courses of antifungal therapy. The attributable mortality of invasive candidiasis in children has","confidence":1,"confidence_rate":1},{"cnt":[[245,733],[1880,733],[1880,780],[245,780]],"region":{"top_left_x":244,"top_left_y":732,"width":1636,"height":48},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1a3b1d6a6ba4272a38f6845a8fb638f","type":"text","conversion_output":true,"text":"been reported to be \\(10 \\%\\). These data suggest that 1 child would be saved for every 10 children in whom","text_display":" been reported to be \\(10 \\%\\). These data suggest that 1 child would be saved for every 10 children in whom","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[245,778],[724,778],[724,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":481,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a896e26f09d0493fbdb76e15413bef50","type":"text","conversion_output":true,"text":"candidemia can be prevented. \\({ }^{6}\\)","text_display":" candidemia can be prevented. \\({ }^{6}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,864],[1880,864],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":863,"width":1636,"height":51},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2a292dcb260428ca643c52d427599c2","type":"text","conversion_output":true,"text":"Infections with Aspergillus spp. account for the vast majority of non-Candida IFI in children with cancer.","text_display":"\n\nInfections with Aspergillus spp. account for the vast majority of non-Candida IFI in children with cancer.","confidence":0.9980475902557373,"confidence_rate":0.9999823936848974},{"cnt":[[245,907],[1880,907],[1880,956],[245,956]],"region":{"top_left_x":244,"top_left_y":906,"width":1636,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbc2232b9e5c4897999ecd5aa8426788","type":"text","conversion_output":true,"text":"Children undergoing AML therapy have the highest risk of IA outside the transplant setting. IA most","text_display":" Children undergoing AML therapy have the highest risk of IA outside the transplant setting. IA most","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1880,954],[1880,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1636,"height":49},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"05ad81a9135f400dad25de41f04ada83","type":"text","conversion_output":true,"text":"commonly presents as pneumonia. Infiltrates are commonly wedge-shaped, pleural-based or nodular and","text_display":" commonly presents as pneumonia. Infiltrates are commonly wedge-shaped, pleural-based or nodular and","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1880,997],[1880,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1636,"height":49},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a4856ab695a446eb0ec1b258aeb7403","type":"text","conversion_output":true,"text":"visible on chest radiographs or CT scans. The infiltrates may initially be accompanied by a halo sign and","text_display":" visible on chest radiographs or CT scans. The infiltrates may initially be accompanied by a halo sign and","confidence":0.998046875,"confidence_rate":0.9999822271139778},{"cnt":[[245,1040],[1880,1040],[1880,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1039,"width":1636,"height":51},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2bb948595914e99a977887177b15a70","type":"text","conversion_output":true,"text":"later by a crescent sign. In children with uncontrolled infection, the infiltrates may be diffuse. Less","text_display":" later by a crescent sign. In children with uncontrolled infection, the infiltrates may be diffuse. Less","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1878,1087],[1878,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1634,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed4a73d7ed3e45cd858e5782b51bccaa","type":"text","conversion_output":true,"text":"commonly, sinusitis may also occur. Finally, Aspergillus can disseminate to the central nervous system.","text_display":" commonly, sinusitis may also occur. Finally, Aspergillus can disseminate to the central nervous system.","confidence":1,"confidence_rate":1},{"cnt":[[245,1126],[1362,1126],[1362,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1125,"width":1119,"height":51},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6faa560372b4a1b91f62cd48d76204a","type":"text","conversion_output":true,"text":"IA is associated with mortality rates in children of greater than \\(50 \\% .^{1,7-11}\\)","text_display":" IA is associated with mortality rates in children of greater than \\(50 \\% .^{1,7-11}\\)","confidence":0.7808017730712891,"confidence_rate":0.997159971876127},{"cnt":[[245,1216],[1880,1216],[1880,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1636,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06e9872f3a414920b5824cd9e724f2bf","type":"text","conversion_output":true,"text":"The burden of IFI in pediatric AML is considerable. CCG 2961 demonstrated that the incidence of IFI in","text_display":"\n\nThe burden of IFI in pediatric AML is considerable. CCG 2961 demonstrated that the incidence of IFI in","confidence":1,"confidence_rate":1},{"cnt":[[245,1261],[1880,1261],[1880,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1261,"width":1636,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26e9e8548ab946ffbba2b56623e53c6e","type":"text","conversion_output":true,"text":"children with AML was \\(13 \\%\\) per treatment phase. Approximately half the infections were caused by","text_display":" children with AML was \\(13 \\%\\) per treatment phase. Approximately half the infections were caused by","confidence":0.9956097602844238,"confidence_rate":0.99995728338697},{"cnt":[[243,1306],[1880,1306],[1880,1351],[243,1351]],"region":{"top_left_x":242,"top_left_y":1306,"width":1638,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3981cd7c8964538bd7a04324215c7d5","type":"text","conversion_output":true,"text":"Aspergillus and the other half by Candida. Most importantly, \\(31 \\%\\) of infection-related deaths were","text_display":" Aspergillus and the other half by Candida. Most importantly, \\(31 \\%\\) of infection-related deaths were","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1880,1349],[1880,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1349,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc3f11243fff41d49d156021aa5b0220","type":"text","conversion_output":true,"text":"associated with Aspergillus, and 25.9\\% of infectious deaths were associated with Candida. \\({ }^{12}\\) In order to","text_display":" associated with Aspergillus, and 25.9\\% of infectious deaths were associated with Candida. \\({ }^{12}\\) In order to","confidence":0.6891164779663086,"confidence_rate":0.9968759407443285},{"cnt":[[245,1392],[1878,1392],[1878,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1634,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45a8a0aa9d6f44f781b9d373e82b04ae","type":"text","conversion_output":true,"text":"impact on survival of children with AML, strategies to reduce IFI are urgently needed. In general, the 3","text_display":" impact on survival of children with AML, strategies to reduce IFI are urgently needed. In general, the 3","confidence":1,"confidence_rate":1},{"cnt":[[245,1435],[1884,1435],[1884,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1435,"width":1641,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"867edc32396f4bab9aa60d4e062292ce","type":"text","conversion_output":true,"text":"types of strategies directed toward fungal infections are prophylaxis, empiric therapy, and treatment of","text_display":" types of strategies directed toward fungal infections are prophylaxis, empiric therapy, and treatment of","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1882,1482],[1882,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1482,"width":1639,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be23b67729fe40cea71bcf91f8891efa","type":"text","conversion_output":true,"text":"IFI. The current rates of IFIs and attributable mortality due to IFI are primarily derived from the setting of","text_display":" IFI. The current rates of IFIs and attributable mortality due to IFI are primarily derived from the setting of","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1880,1525],[1880,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85e67f38b26a4e548cb1c3c2d1659856","type":"text","conversion_output":true,"text":"empiric therapy and treatment with best available agents, and thus, these strategies currently are","text_display":" empiric therapy and treatment with best available agents, and thus, these strategies currently are","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1880,1568],[1880,1616],[245,1616]],"region":{"top_left_x":244,"top_left_y":1568,"width":1636,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"737c6c32318e46548e63e39eefe361b5","type":"text","conversion_output":true,"text":"insufficient to make a major impact on fungal morbidity and mortality. Thus, strategies to prevent IFI","text_display":" insufficient to make a major impact on fungal morbidity and mortality. Thus, strategies to prevent IFI","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1880,1611],[1880,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1636,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76ff5fec8631403c87fe16343b179d30","type":"text","conversion_output":true,"text":"should be the priority. Furthermore, IFIs likely impact on the ability to deliver anti-leukemic therapy and","text_display":" should be the priority. 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best agent for patients with AML since it lacks activity against filamentous fungi (e.g. Aspergillus),","text_display":"\nthe best agent for patients with AML since it lacks activity against filamentous fungi (e.g. Aspergillus),","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1184,296],[1184,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":940,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4194e876e7f649d5bad3ec8b39ceca59","type":"text","conversion_output":true,"text":"which represent half the causes of IFI in children with AML.","text_display":" which represent half the causes of IFI in children with 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The first European Conference on Infections in Leukemia, published in 2007, recommended","text_display":" guidelines. 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Itraconazole has","text_display":"\n\nAnother possible agent which could have been chosen as the control arm is itraconazole. 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However,","text_display":" to be more effective than fluconazole when used for prophylaxis in patients with neutropenia. However,","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1880,1042],[1880,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1636,"height":49},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42681e047d37499cafc2e3fdddf43063","type":"text","conversion_output":true,"text":"the clinical usefulness of itraconazole is limited by poor tolerability and bioavailability of the oral","text_display":" the clinical usefulness of itraconazole is limited by poor tolerability and bioavailability of the oral","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[458,1087],[458,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1087,"width":214,"height":41},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d721019cc574f2188c13503f8e68e3d","type":"text","conversion_output":true,"text":"formulations.","text_display":" formulations.","confidence":1,"confidence_rate":1},{"cnt":[[241,1169],[1304,1169],[1304,1222],[241,1222]],"region":{"top_left_x":240,"top_left_y":1168,"width":1065,"height":55},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcfc00e5de3b4b0e9052367972239d40","type":"section_header","conversion_output":false,"children_ids":["c35171e809bf4849a8b9569c46b1b932"],"text":"","text_display":""},{"cnt":[[245,1173],[1300,1173],[1300,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1173,"width":1056,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c35171e809bf4849a8b9569c46b1b932","type":"text","conversion_output":true,"parent_id":"bcfc00e5de3b4b0e9052367972239d40","text":"2.2.2 Choice of Caspofungin Prophylaxis as the Intervention Arm","text_display":"\n\n\\subsection*{2.2.2 Choice of Caspofungin Prophylaxis as the Intervention Arm}","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1880,1216],[1880,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1636,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2b65dc2492d4f6494e72777fcb70ce5","type":"text","conversion_output":true,"text":"Newer antifungal agents with a broader spectrum of activity that have been considered as study","text_display":"\n\nNewer antifungal agents with a broader spectrum of activity that have been considered as study","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1878,1263],[1878,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1263,"width":1634,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be45a669591040e9910142c4c5f5b220","type":"text","conversion_output":true,"text":"medications include the newer azoles (voriconazole, posaconazole) and the echinocandins (caspofungin,","text_display":" medications include the newer azoles (voriconazole, posaconazole) and the echinocandins (caspofungin,","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1880,1306],[1880,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"238a1c5869474fac9694ad52d644296b","type":"text","conversion_output":true,"text":"micafungin, anidulafungin). 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Voriconazole was compared to liposomal","text_display":" antifungal setting as it may shed insight into its efficacy. 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The overall success rates were \\(26 \\%\\) for","text_display":" was a large, randomized trial that included over 800 patients. The overall success rates were \\(26 \\%\\) for","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1880,2402],[1880,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1636,"height":51},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5aeef61fdbe42f6915ea80faee8bf58","type":"text","conversion_output":true,"text":"voriconazole and \\(30.6 \\%\\) for liposomal amphotericin B ( \\(95 \\%\\) confidence interval for the difference, -10.6","text_display":" voriconazole and \\(30.6 \\%\\) for liposomal amphotericin B ( \\(95 \\%\\) confidence interval for the difference, -10.6","confidence":0.9680914445971212,"confidence_rate":0.999727526803126},{"cnt":[[245,2447],[1880,2447],[1880,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2447,"width":1636,"height":48},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab89c37fc87d4981b4ad9dbc079ee131","type":"text","conversion_output":true,"text":"to 1.6). 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of voriconazole was an open label, compassionate-use evaluation in","text_display":"\n\nThe largest pediatric study of voriconazole was an open label, compassionate-use evaluation in","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1880,430],[1880,477],[245,477]],"region":{"top_left_x":244,"top_left_y":429,"width":1636,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a411395326be4df49897f5dfbdc13944","type":"text","conversion_output":true,"text":"58 children with proven or probable IFI refractory to or intolerant of conventional antifungal therapy. \\({ }^{23}\\)","text_display":" 58 children with proven or probable IFI refractory to or intolerant of conventional antifungal therapy. \\({ }^{23}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,475],[1463,475],[1463,522],[245,522]],"region":{"top_left_x":244,"top_left_y":474,"width":1220,"height":49},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5070d1a2d3e442fa8645a6beb9176454","type":"text","conversion_output":true,"text":"Forty-five percent of the patients had a complete or partial response to therapy.","text_display":" Forty-five percent of the patients had a complete or partial response to therapy.","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[245,563],[1880,563],[1880,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b04752a0e664bfabf2f46a66065ba6d","type":"text","conversion_output":true,"text":"Metabolism of voriconazole occurs in the liver via CYP450 enzyme family, including CYP2C9,","text_display":"\n\nMetabolism of voriconazole occurs in the liver via CYP450 enzyme family, including CYP2C9,","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1880,606],[1880,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1636,"height":51},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d73d027802ed4bd6bdfb5787b7be2640","type":"text","conversion_output":true,"text":"CYP3A4, and CYP2C19 isoenzymes \\({ }^{24}\\) and therefore, the potential for drug interactions with voriconazole","text_display":" CYP3A4, and CYP2C19 isoenzymes \\({ }^{24}\\) and therefore, the potential for drug interactions with voriconazole","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1880,649],[1880,694],[245,694]],"region":{"top_left_x":244,"top_left_y":648,"width":1636,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc1883afe3fb4679af55e021cfd7a9cf","type":"text","conversion_output":true,"text":"is high. The main side effects of voriconazole include visual disturbances, skin rashes, elevations in","text_display":" is high. The main side effects of voriconazole include visual disturbances, skin rashes, elevations in","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1216,692],[1216,741],[245,741]],"region":{"top_left_x":244,"top_left_y":691,"width":973,"height":51},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4af929cd28c94c2db775ad88f0e49ae1","type":"text","conversion_output":true,"text":"hepatic enzymes and rarely, severe, life-threatening hepatitis. \\({ }^{24}\\)","text_display":" hepatic enzymes and rarely, severe, life-threatening hepatitis. \\({ }^{24}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1880,782],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":782,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0dc8416638c4b438c67bf3c8140642b","type":"text","conversion_output":true,"text":"When evaluating studies of antifungal agents with anti-mold activity vs. fluconazole, there are three trials","text_display":"\n\nWhen evaluating studies of antifungal agents with anti-mold activity vs. fluconazole, there are three trials","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1880,825],[1880,870],[245,870]],"region":{"top_left_x":244,"top_left_y":825,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e516f9af3934056913f164fed76b0cb","type":"text","conversion_output":true,"text":"that showed improved survival and/or a lower rate of IFI when anti-mold agents were compared to","text_display":" that showed improved survival and/or a lower rate of IFI when anti-mold agents were compared to","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1880,868],[1880,917],[245,917]],"region":{"top_left_x":244,"top_left_y":867,"width":1636,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb50e315a01d47dda3f900e426075a9f","type":"text","conversion_output":true,"text":"fluconazole. Two of the studies used posaconazole and one trial used micafungin. \\({ }^{25,26}\\) In other words,","text_display":" fluconazole. Two of the studies used posaconazole and one trial used micafungin. \\({ }^{25,26}\\) In other words,","confidence":1,"confidence_rate":1},{"cnt":[[245,915],[1880,915],[1880,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"065edced5f344cefb6c63c5f89f5bd6f","type":"text","conversion_output":true,"text":"there are no studies that have demonstrated that voriconazole is superior to fluconazole as prophylaxis","text_display":" there are no studies that have demonstrated that voriconazole is superior to fluconazole as prophylaxis","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[1880,958],[1880,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":958,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"983b31a246df4fe88ab5d38a89873720","type":"text","conversion_output":true,"text":"against IFI. Therefore, the decision not to use voriconazole as the comparator in this trial was based on","text_display":" against IFI. Therefore, the decision not to use voriconazole as the comparator in this trial was based on","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1880,1001],[1880,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1636,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cafe834c2ac240b680cab30d578f8382","type":"text","conversion_output":true,"text":"available data that show no significant advantage over fluconazole or itraconazole, the potential for","text_display":" available data that show no significant advantage over fluconazole or itraconazole, the potential for","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,1044],[1880,1044],[1880,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":1636,"height":50},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42eca980148e4b64b2dc1a2c9dcfc9a0","type":"text","conversion_output":true,"text":"toxicity, and the potential for drug interactions in children receiving AML chemotherapy. Furthermore,","text_display":" toxicity, and the potential for drug interactions in children receiving AML chemotherapy. Furthermore,","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[1880,1091],[1880,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1091,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"070ecbb00c37476db16e66b2bd224891","type":"text","conversion_output":true,"text":"pharmacokinetics and appropriate dosing are less certain in children compared with adults, thus making","text_display":" pharmacokinetics and appropriate dosing are less certain in children compared with adults, thus making","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[1038,1134],[1038,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1134,"width":794,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc617d7a29d84dd5a1f203979ec8d06a","type":"text","conversion_output":true,"text":"voriconazole even less attractive in this population.","text_display":" voriconazole even less attractive in this population.","confidence":1,"confidence_rate":1},{"cnt":[[245,1222],[1880,1222],[1880,1268],[245,1268]],"region":{"top_left_x":244,"top_left_y":1222,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"444f2bfea2f04606a0f8609b4511e21a","type":"text","conversion_output":true,"text":"Posaconazole is an attractive agent to consider as antifungal prophylaxis in the AML population. A","text_display":"\n\nPosaconazole is an attractive agent to consider as antifungal prophylaxis in the AML population. A","confidence":1,"confidence_rate":1},{"cnt":[[245,1265],[1880,1265],[1880,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1265,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8217702f314e492e8538dd6f906c6103","type":"text","conversion_output":true,"text":"randomized, multi-center study of posaconazole vs. fluconazole or itraconazole in patients with","text_display":" randomized, multi-center study of posaconazole vs. fluconazole or itraconazole in patients with","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1880,1311],[1880,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1310,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86f26e1ec41a454b9326d739b12b9bef","type":"text","conversion_output":true,"text":"neutropenia associated with the treatment of AML or myelodysplastic syndrome found that posaconazole","text_display":" neutropenia associated with the treatment of AML or myelodysplastic syndrome found that posaconazole","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1882,1354],[1882,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1639,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e24ffac9dae457d842cf9eb53e1658b","type":"text","conversion_output":true,"text":"reduced the rate of IFI from \\(8 \\%\\) to \\(2 \\%\\) compared to fluconazole. However, children less than 13 years of","text_display":" reduced the rate of IFI from \\(8 \\%\\) to \\(2 \\%\\) compared to fluconazole. However, children less than 13 years of","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[245,1396],[1880,1396],[1880,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1636,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8a7c01327b04976966dfb72166fac5a","type":"text","conversion_output":true,"text":"age were excluded and the median age of study subjects was approximately 50 years of age. \\({ }^{25}\\) Its use is","text_display":" age were excluded and the median age of study subjects was approximately 50 years of age. \\({ }^{25}\\) Its use is","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1880,1439],[1880,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"587691f0a8ca43178e52c038e32ecff2","type":"text","conversion_output":true,"text":"limited in children because of insufficient dosing information for young children. Furthermore,","text_display":" limited in children because of insufficient dosing information for young children. Furthermore,","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1880,1487],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f401e933e79e42b5b3c858bb54c872f1","type":"text","conversion_output":true,"text":"posaconazole has the same concerns regarding hepatotoxicity and drug interactions as exist for","text_display":" posaconazole has the same concerns regarding hepatotoxicity and drug interactions as exist for","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1880,1530],[1880,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1706f407c533460fa4681ea7d2761c9a","type":"text","conversion_output":true,"text":"voriconazole. Finally, posaconazole can only be administered as an oral agent currently and children","text_display":" voriconazole. Finally, posaconazole can only be administered as an oral agent currently and children","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1878,1573],[1878,1620],[245,1620]],"region":{"top_left_x":244,"top_left_y":1572,"width":1634,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"499c17ec485f4b15ab6f475d39c15a13","type":"text","conversion_output":true,"text":"receiving AML therapy may not be able to comply with oral medication during the neutropenic period.","text_display":" receiving AML therapy may not be able to comply with oral medication during the neutropenic period.","confidence":1,"confidence_rate":1},{"cnt":[[245,1616],[1678,1616],[1678,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1615,"width":1434,"height":51},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d36f1c72497140aaa6d23fa4f2d686d3","type":"text","conversion_output":true,"text":"Therefore, posaconazole is not an appropriate agent to use in children with AML at this time.","text_display":" Therefore, posaconazole is not an appropriate agent to use in children with AML at this time.","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,1706],[1880,1706],[1880,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1705,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f54f23d3459f42bab4448c7e91088398","type":"text","conversion_output":true,"text":"The next COG Phase 3 AML trial will randomize subjects to receive or not receive bortezomib and there","text_display":"\n\nThe next COG Phase 3 AML trial will randomize subjects to receive or not receive bortezomib and there","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1880,1749],[1880,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c12982841d74b7a9e6d002d8cb08a65","type":"text","conversion_output":true,"text":"is considerable risk of drug interactions with concurrent administration of bortezomib and either","text_display":" is considerable risk of drug interactions with concurrent administration of bortezomib and either","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1764,1792],[1764,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1520,"height":51},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d84fd1280f44d129be6f750a5995c7f","type":"text","conversion_output":true,"text":"voriconazole or posaconazole, thus further decreasing the feasibility of their use in pediatric AML.","text_display":" voriconazole or posaconazole, thus further decreasing the feasibility of their use in pediatric AML.","confidence":1,"confidence_rate":1},{"cnt":[[241,1878],[874,1878],[874,1927],[241,1927]],"region":{"top_left_x":240,"top_left_y":1877,"width":635,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4059a0d79c924448886b636579e9912c","type":"section_header","conversion_output":false,"children_ids":["c7fb672c4dfb487aa41aa8e836927a65"],"text":"","text_display":""},{"cnt":[[245,1882],[870,1882],[870,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1882,"width":627,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7fb672c4dfb487aa41aa8e836927a65","type":"text","conversion_output":true,"parent_id":"4059a0d79c924448886b636579e9912c","text":"2.2.2.2 Echinocandin Antifungal Agents","text_display":"\n\n\\subsection*{2.2.2.2 Echinocandin Antifungal Agents}","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1880,1925],[1880,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3d0ca57e3544439ac559521e422ef07","type":"text","conversion_output":true,"text":"Echinocandins target cell wall biosynthesis of \\(\\beta\\)-1, 3-glucan and exhibit in vitro activity against both","text_display":"\n\nEchinocandins target cell wall biosynthesis of \\(\\beta\\)-1, 3-glucan and exhibit in vitro activity against both","confidence":0.928643105053311,"confidence_rate":0.9993392292527479},{"cnt":[[245,1968],[1878,1968],[1878,2015],[245,2015]],"region":{"top_left_x":244,"top_left_y":1967,"width":1634,"height":49},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6add8de85ee045ada5d2af4411c11af1","type":"text","conversion_output":true,"text":"Candida and Aspergillus species. There are 3 currently available echinocandins, namely micafungin,","text_display":" Candida and Aspergillus species. There are 3 currently available echinocandins, namely micafungin,","confidence":0.9990234375,"confidence_rate":0.9999907826873116},{"cnt":[[245,2011],[737,2011],[737,2058],[245,2058]],"region":{"top_left_x":244,"top_left_y":2010,"width":493,"height":49},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29832b92de214a7c99c857feb18cdb2f","type":"text","conversion_output":true,"text":"anidulofungin and caspofungin.","text_display":" anidulofungin and caspofungin.","confidence":1,"confidence_rate":1},{"cnt":[[245,2099],[1880,2099],[1880,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2099,"width":1636,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c930672550fd4346aa84252d01223a3a","type":"text","conversion_output":true,"text":"Micafungin has been studied in children with cancer. A Phase I pediatric febrile neutropenia study found","text_display":"\n\nMicafungin has been studied in children with cancer. A Phase I pediatric febrile neutropenia study found","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1880,2144],[1880,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1636,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21b3d118055d40f3917ef8313737944b","type":"text","conversion_output":true,"text":"that doses up to \\(4 mg / kg /\\) day IV were well tolerated with no side effects. \\({ }^{27}\\) A recent study of micafungin","text_display":" that doses up to \\(4 mg / kg /\\) day IV were well tolerated with no side effects. \\({ }^{27}\\) A recent study of micafungin","confidence":0.99951171875,"confidence_rate":0.9999962139567942},{"cnt":[[245,2187],[1880,2187],[1880,2232],[245,2232]],"region":{"top_left_x":244,"top_left_y":2187,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebe4f07e0f124e7d9f3c8d0a70176f56","type":"text","conversion_output":true,"text":"in combination with a second antifungal agent in pediatric and adult bone marrow recipients with IA","text_display":" in combination with a second antifungal agent in pediatric and adult bone marrow recipients with IA","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1880,2230],[1880,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1636,"height":50},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5145380938f943018305e4f04c63df9b","type":"text","conversion_output":true,"text":"revealed an overall response rate of \\(40 \\% .^{28}\\) The success rate in the pediatric patient population was similar","text_display":" revealed an overall response rate of \\(40 \\% .^{28}\\) The success rate in the pediatric patient population was similar","confidence":0.93994140625,"confidence_rate":0.999496567907267},{"cnt":[[245,2277],[1880,2277],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2277,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9785924923f445ef8468756f59e452a2","type":"text","conversion_output":true,"text":"to the adult patients. Pediatric patients were also enrolled in a recent micafungin prophylaxis study in","text_display":" to the adult patients. Pediatric patients were also enrolled in a recent micafungin prophylaxis study in","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1884,2316],[1884,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2316,"width":1641,"height":50},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59856196e7a9443191b3bffa2743b7b1","type":"text","conversion_output":true,"text":"patients undergoing HSCT. \\({ }^{26}\\) This study was a randomized, double-blind, multi-center study of","text_display":" patients undergoing HSCT. \\({ }^{26}\\) This study was a randomized, double-blind, multi-center study of","confidence":1,"confidence_rate":1},{"cnt":[[245,2363],[1880,2363],[1880,2411],[245,2411]],"region":{"top_left_x":244,"top_left_y":2363,"width":1636,"height":48},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32942b840e0d427aabf4ef3202b1092b","type":"text","conversion_output":true,"text":"882 patients, of which \\(10 \\%\\) were children younger than 16 years of age. Although the study did not have","text_display":" 882 patients, of which \\(10 \\%\\) were children younger than 16 years of age. Although the study did not have","confidence":0.9367848699912429,"confidence_rate":0.9994171197838891},{"cnt":[[245,2408],[1880,2408],[1880,2454],[245,2454]],"region":{"top_left_x":244,"top_left_y":2408,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"585045096e394fc3ba70b490ff6f4046","type":"text","conversion_output":true,"text":"statistical power to specifically address efficacy in the pediatric subgroup, the magnitude and the direction","text_display":" statistical power to specifically address efficacy in the pediatric subgroup, the magnitude and the direction","confidence":1,"confidence_rate":1},{"cnt":[[245,2449],[1880,2449],[1880,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2449,"width":1636,"height":50},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61ad591232724937b445d24d8f51fcfc","type":"text","conversion_output":true,"text":"of micafungin efficacy were similar in children and adults. \\({ }^{26}\\) Dosing in children under the age of 8 years","text_display":" of micafungin efficacy were similar in children and adults. \\({ }^{26}\\) Dosing in children under the age of 8 years","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[612,2582],[612,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":369,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0523003bc9b46bea7f3770d21619e75","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1876,2582],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":128,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9beb03ea62e94bebad98beb84598241c","type":"page_info","conversion_output":false,"text":"Page 11","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"30d0fca4-08d7-48bb-b63f-1324b67d52fd-12","page":12,"lines":[{"cnt":[[262,88],[436,88],[436,122],[262,122]],"region":{"top_left_x":262,"top_left_y":88,"width":175,"height":35},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b29e1388c4ef4b249af3704eef9d7cfc","type":"page_info","conversion_output":false,"text":"CHILDREN'S","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,120],[415,120],[415,157],[262,157]],"region":{"top_left_x":262,"top_left_y":120,"width":153,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6cf98f587df54493a5d77d794ada8ae1","type":"page_info","conversion_output":false,"text":"ONCOLOGY","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[494,129],[1497,129],[1497,170],[494,170]],"region":{"top_left_x":494,"top_left_y":128,"width":1004,"height":42},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"33b2000067dc4e9586923317bdc532f6","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.9761475823079309,"confidence_rate":0.999698276869841},{"cnt":[[1691,125],[1880,125],[1880,165],[1691,165]],"region":{"top_left_x":1690,"top_left_y":124,"width":190,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3aedc62b18f944debbf6c889267c29ba","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[363,155],[363,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":102,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5c0d37b68166443da264ca8d2ea23bdb","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1880,249],[1880,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1636,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d36dc2e7fd8438eb18cf48fe681329a","type":"text","conversion_output":true,"text":"appears to yield a higher clearance of micafungin, resulting in the likely need for an increased dose in this","text_display":"\nappears to yield a higher clearance of micafungin, resulting in the likely need for an increased dose in this","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5f14caf050b4ad7b83fae016b0efa03","type":"text","conversion_output":true,"text":"age group. Despite the pharmacokinetic studies and its recent FDA approval in adults, there is no","text_display":" age group. Despite the pharmacokinetic studies and its recent FDA approval in adults, there is no","confidence":0.99560546875,"confidence_rate":0.9999568223480155},{"cnt":[[245,339],[1051,339],[1051,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":807,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50a06c6ea9f747a9821580f6833ed3c7","type":"text","conversion_output":true,"text":"accepted dosage of micafungin in pediatric patients.","text_display":" accepted dosage of micafungin in pediatric patients.","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e766114ebd34efcb92d5861e95f8a0f","type":"text","conversion_output":true,"text":"Anidulafungin has the least data in pediatric patients. A Phase I/II dose escalation study of anidulafungin","text_display":"\n\nAnidulafungin has the least data in pediatric patients. A Phase I/II dose escalation study of anidulafungin","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1880,473],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bef728f600804b729789db944f6d6e57","type":"text","conversion_output":true,"text":"in children with persistent neutropenia showed that the drug was well tolerated in pediatric patients and","text_display":" in children with persistent neutropenia showed that the drug was well tolerated in pediatric patients and","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1880,516],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f776d28910947d0b80073ab0fc1b9e2","type":"text","conversion_output":true,"text":"can be dosed based on body weight. Pediatric patients receiving 0.75 or \\(1.5 mg / kg / day\\) IV have","text_display":" can be dosed based on body weight. Pediatric patients receiving 0.75 or \\(1.5 mg / kg / day\\) IV have","confidence":0.64404296875,"confidence_rate":0.9960792257296336},{"cnt":[[245,556],[1609,556],[1609,608],[245,608]],"region":{"top_left_x":244,"top_left_y":556,"width":1366,"height":53},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25c7dada905e4c91abfbdfefc11b7d34","type":"text","conversion_output":true,"text":"pharmacokinetic properties similar to adults receiving \\(50-100 mg / kg /\\) day, respectively. \\({ }^{29}\\)","text_display":" pharmacokinetic properties similar to adults receiving \\(50-100 mg / kg /\\) day, respectively. \\({ }^{29}\\)","confidence":0.67919921875,"confidence_rate":0.9964572921379816},{"cnt":[[245,647],[1880,647],[1880,694],[245,694]],"region":{"top_left_x":244,"top_left_y":646,"width":1636,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eec72ffa0d6644f192a9eec221ba3d03","type":"text","conversion_output":true,"text":"Among the echinocandins, caspofungin is the most extensively studied agent in children. Caspofungin","text_display":"\n\nAmong the echinocandins, caspofungin is the most extensively studied agent in children. Caspofungin","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1880,692],[1880,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c51f595e0f7344c28e38adfd30625d3a","type":"text","conversion_output":true,"text":"recently received FDA approval for use in children \\(\\geq 3\\) months of age. There have been 5 pediatric","text_display":" recently received FDA approval for use in children \\(\\geq 3\\) months of age. There have been 5 pediatric","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1880,735],[1880,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f297e43e380d4bc5b90310fde12316d3","type":"text","conversion_output":true,"text":"caspofungin studies ( 3 pharmacokinetic and 2 safety/efficacy trials). A multicenter, prospective, open-","text_display":" caspofungin studies ( 3 pharmacokinetic and 2 safety/efficacy trials). A multicenter, prospective, open","confidence":0.951195478439331,"confidence_rate":0.9995650017074649},{"cnt":[[245,776],[1880,776],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":775,"width":1636,"height":53},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48c476ce1495458e913c6e398f29ec8d","type":"text","conversion_output":true,"text":"label study in 50 children with proven candidiasis or aspergillosis was recently completed. \\({ }^{30}\\) Caspofungin","text_display":"label study in 50 children with proven candidiasis or aspergillosis was recently completed. \\({ }^{30}\\) Caspofungin","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1880,821],[1880,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1636,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94e592cada834b379f57ac0c2cd335d3","type":"text","conversion_output":true,"text":"was well-tolerated. Fifty percent of children with IA and \\(81 \\%\\) of children with invasive candidiasis were","text_display":" was well-tolerated. Fifty percent of children with IA and \\(81 \\%\\) of children with invasive candidiasis were","confidence":1,"confidence_rate":1},{"cnt":[[245,866],[1880,866],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":865,"width":1636,"height":49},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c24094ba4c249ffab75808af2ea8c0b","type":"text","conversion_output":true,"text":"successfully treated. These efficacy outcomes were consistent with previous adult studies focused on","text_display":" successfully treated. These efficacy outcomes were consistent with previous adult studies focused on","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1880,911],[1880,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1636,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e65dbd4c584419e9e3ace7877c297e7","type":"text","conversion_output":true,"text":"these infections. A randomized, double-blind, multicenter trial of caspofungin vs. liposomal amphotericin","text_display":" these infections. A randomized, double-blind, multicenter trial of caspofungin vs. liposomal amphotericin","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1880,954],[1880,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1636,"height":49},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"562315fb1f764ae5b4f088f7796e6581","type":"text","conversion_output":true,"text":"for empirical antifungal therapy of pediatric patients with persistent fever and neutropenia was also","text_display":" for empirical antifungal therapy of pediatric patients with persistent fever and neutropenia was also","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1880,997],[1880,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1636,"height":49},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fa29fe1fd7c43cca6fad2286d99e3dd","type":"text","conversion_output":true,"text":"completed. Overall success rates were \\(41 \\%\\) for caspofungin vs. \\(28 \\%\\) for liposomal amphotericin;","text_display":" completed. Overall success rates were \\(41 \\%\\) for caspofungin vs. \\(28 \\%\\) for liposomal amphotericin;","confidence":1,"confidence_rate":1},{"cnt":[[245,1040],[1880,1040],[1880,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1039,"width":1636,"height":51},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8958d9cf40814fa38d78674dedb8f867","type":"text","conversion_output":true,"text":"however, this difference did not reach statistical significance. \\({ }^{31}\\) Caspofungin demonstrated efficacy","text_display":" however, this difference did not reach statistical significance. \\({ }^{31}\\) Caspofungin demonstrated efficacy","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1880,1087],[1880,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c64aeead8d846389bad0f48abcc81a9","type":"text","conversion_output":true,"text":"consistent with adult data for this indication. A comprehensive review of the safety of caspofungin across","text_display":" consistent with adult data for this indication. A comprehensive review of the safety of caspofungin across","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1880,1130],[1880,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2376b4b6ac8a41408eee140fb4f6f209","type":"text","conversion_output":true,"text":"the 5 pediatric studies was performed. Of the 171 children receiving caspofungin, therapy was","text_display":" the 5 pediatric studies was performed. Of the 171 children receiving caspofungin, therapy was","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1880,1173],[1880,1220],[245,1220]],"region":{"top_left_x":244,"top_left_y":1173,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75a915a48cca46e88db420d1c458839a","type":"text","conversion_output":true,"text":"discontinued due to drug-related adverse events in 3 patients. Elevations in serum transaminases were","text_display":" discontinued due to drug-related adverse events in 3 patients. Elevations in serum transaminases were","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1880,1216],[1880,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1636,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b71c869bb0c24f02b771eac63636fc96","type":"text","conversion_output":true,"text":"seen in \\(8 \\%\\) of patients. \\({ }^{32}\\) The currently recommended pediatric dose of caspofungin in children is","text_display":" seen in \\(8 \\%\\) of patients. \\({ }^{32}\\) The currently recommended pediatric dose of caspofungin in children is","confidence":1,"confidence_rate":1},{"cnt":[[245,1259],[1880,1259],[1880,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1258,"width":1636,"height":51},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e618c372bb5450c8c37e80894b882c1","type":"text","conversion_output":true,"text":"\\(70 mg / m ^{2} /\\) day IV on the first day of therapy followed by \\(50 mg / m ^{2} /\\) day IV for subsequent days. The","text_display":" \\(70 mg / m ^{2} /\\) day IV on the first day of therapy followed by \\(50 mg / m ^{2} /\\) day IV for subsequent days. The","confidence":0.6038243207149208,"confidence_rate":0.9960970010493523},{"cnt":[[245,1306],[1601,1306],[1601,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1357,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"912b6350dd0c4188b8e6e2e6bf91c348","type":"text","conversion_output":true,"text":"maximum daily loading dose is 70 mg . The maximum daily maintenance dose is 50 mg .","text_display":" maximum daily loading dose is 70 mg . The maximum daily maintenance dose is 50 mg .","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[1880,1392],[1880,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1636,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afd5e24210fa4cef9b02f916efc870e5","type":"text","conversion_output":true,"text":"Based on the available dosing data, safety data, and efficacy data regarding the echinocandins,","text_display":"\n\nBased on the available dosing data, safety data, and efficacy data regarding the echinocandins,","confidence":1,"confidence_rate":1},{"cnt":[[245,1437],[1878,1437],[1878,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1437,"width":1634,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a46a7034a16a4fbd98a9391412eefb1c","type":"text","conversion_output":true,"text":"caspofungin has been chosen as the best suited agent to take forward into studies of antifungal","text_display":" caspofungin has been chosen as the best suited agent to take forward into studies of antifungal","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1880,1482],[1880,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1482,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a42181dc5de8402a8f9281f31f693520","type":"text","conversion_output":true,"text":"prophylaxis in pediatric AML patients because it is the only echinocandin approved for use in children as","text_display":" prophylaxis in pediatric AML patients because it is the only echinocandin approved for use in children as","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1880,1525],[1880,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"908f69c001bf4eae9af63db61bdcff6a","type":"text","conversion_output":true,"text":"young as 3 months of age and because of extensive experience in children with cancer. Furthermore, there","text_display":" young as 3 months of age and because of extensive experience in children with cancer. Furthermore, there","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1880,1568],[1880,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1636,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6039200a27ff47659c216f912f385de0","type":"text","conversion_output":true,"text":"have been safety concerns raised recently regarding the use of micafungin in children from the European","text_display":" have been safety concerns raised recently regarding the use of micafungin in children from the European","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1699,1611],[1699,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1456,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6062e7bb8484be28a26392a16826b0c","type":"text","conversion_output":true,"text":"Medicines Agency. \\({ }^{33}\\) Finally, there is no approved dosing for anidulofungin in young children.","text_display":" Medicines Agency. \\({ }^{33}\\) Finally, there is no approved dosing for anidulofungin in young children.","confidence":1,"confidence_rate":1},{"cnt":[[236,1693],[1637,1693],[1637,1755],[236,1755]],"region":{"top_left_x":236,"top_left_y":1692,"width":1402,"height":64},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecff00bf531d4e3c8084aca54ab4377f","type":"section_header","conversion_output":false,"children_ids":["49f26cfbb0bb4708ab6fce4e02720c60"],"text":"","text_display":""},{"cnt":[[245,1697],[1629,1697],[1629,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1697,"width":1385,"height":50},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49f26cfbb0bb4708ab6fce4e02720c60","type":"text","conversion_output":true,"parent_id":"ecff00bf531d4e3c8084aca54ab4377f","text":"2.3 Rationale for Platelia EIA Aspergillus GM and Serum Beta-D Glucan Assays","text_display":"\n\n\\subsection*{2.3 Rationale for Platelia EIA Aspergillus GM and Serum Beta-D Glucan Assays}","confidence":0.99951171875,"confidence_rate":0.9999939703823991},{"cnt":[[245,1745],[1880,1745],[1880,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1744,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e6e986d770f4689b652c8b00e831f5d","type":"text","conversion_output":true,"text":"The diagnosis of IFI, especially IA, is often difficult because of the lack of specific clinical symptoms in","text_display":"\n\nThe diagnosis of IFI, especially IA, is often difficult because of the lack of specific clinical symptoms in","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1880,1788],[1880,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1636,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65dbddd1c899413db28ebdce55bda5b4","type":"text","conversion_output":true,"text":"high-risk patients and the invasiveness of standard diagnostic tests. Therefore much attention has been","text_display":" high-risk patients and the invasiveness of standard diagnostic tests. Therefore much attention has been","confidence":1,"confidence_rate":1},{"cnt":[[245,1833],[1880,1833],[1880,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1832,"width":1636,"height":48},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4b7d5422e3746bba43e0b44afca5559","type":"text","conversion_output":true,"text":"focused on developing non-invasive tests for diagnosing IFI. GM is a polysaccharide cell-wall component","text_display":" focused on developing non-invasive tests for diagnosing IFI. GM is a polysaccharide cell-wall component","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1880,1878],[1880,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1877,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0fdede2c9f345e88c805f6fa499e3bd","type":"text","conversion_output":true,"text":"that is released by Aspergillus during growth. The Platelia EIA Aspergillus GM assay was approved by","text_display":" that is released by Aspergillus during growth. The Platelia EIA Aspergillus GM assay was approved by","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1880,1921],[1880,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6cd67d68faa4416a5b257103ff3cf7c","type":"text","conversion_output":true,"text":"the FDA in 2003 for use in adult patients. \\({ }^{34}\\) Early large scale clinical testing included few children, but","text_display":" the FDA in 2003 for use in adult patients. \\({ }^{34}\\) Early large scale clinical testing included few children, but","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1880,1964],[1880,2011],[245,2011]],"region":{"top_left_x":244,"top_left_y":1963,"width":1636,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ab4b87c8c654aa8b7809dae87034b54","type":"text","conversion_output":true,"text":"available data suggest that detection values for adult patients may not be extrapolated to children. \\({ }^{35}\\)","text_display":" available data suggest that detection values for adult patients may not be extrapolated to children. \\({ }^{35}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1880,2007],[1880,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1636,"height":51},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01efb5a7e8c84bac802f9dd7c4d5b6bf","type":"text","conversion_output":true,"text":"Furthermore, the utility of the GM assay in pediatric patients has not been rigorously studied in a","text_display":" Furthermore, the utility of the GM assay in pediatric patients has not been rigorously studied in a","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1880,2054],[1880,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2053,"width":1636,"height":47},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"389339bfb1cb4fd79660713edd4b879e","type":"text","conversion_output":true,"text":"prospective manner and therefore its true value as a diagnostic test in children is still unclear. Serum beta-","text_display":" prospective manner and therefore its true value as a diagnostic test in children is still unclear. Serum beta","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1880,2097],[1880,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07f0d31aa02845d2ad8c915dd77cc46f","type":"text","conversion_output":true,"text":"D glucan (found in all fungi except Cryptococcus species and Zygomycetes) can be detected using an","text_display":"D glucan (found in all fungi except Cryptococcus species and Zygomycetes) can be detected using an","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1880,2140],[1880,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2139,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e0afc1cc4974cf6ac92e711043680f9","type":"text","conversion_output":true,"text":"approved diagnostic serum assay and has been found to have high specificity and high positive predictive","text_display":" approved diagnostic serum assay and has been found to have high specificity and high positive predictive","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1880,2183],[1880,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2182,"width":1636,"height":49},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b647c743b5e14a51bb94b0f8513022fe","type":"text","conversion_output":true,"text":"values for the detection of IFI in adults. \\({ }^{36}\\) However, data on the performance of this assay in children are","text_display":" values for the detection of IFI in adults. \\({ }^{36}\\) However, data on the performance of this assay in children are","confidence":1,"confidence_rate":1},{"cnt":[[245,2228],[1880,2228],[1880,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2227,"width":1636,"height":49},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35e0c02a41944462aa50fd8046a4b159","type":"text","conversion_output":true,"text":"limited. Data suggests that combining GM testing with beta-D glucan testing would further improve the","text_display":" limited. Data suggests that combining GM testing with beta-D glucan testing would further improve the","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1880,2273],[1880,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"292277b1c9dc40d99ce615f2f996c725","type":"text","conversion_output":true,"text":"usefulness of the test; twice weekly testing having been suggested as practical to enable reasonably","text_display":" usefulness of the test; twice weekly testing having been suggested as practical to enable reasonably","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1588,2316],[1588,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2316,"width":1344,"height":50},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"efe54bb7526647cc8e14163663c9156f","type":"text","conversion_output":true,"text":"prompt diagnosis of IFI. \\({ 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Rationale for Single Nucleotide Polymorphism (SNP) Aim","text_display":"\n\n\\subsection*{2.4 Rationale for Single Nucleotide Polymorphism (SNP) Aim}","confidence":1,"confidence_rate":1},{"cnt":[[245,294],[1880,294],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":294,"width":1636,"height":48},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19111d5dba7344a590ca96a9030a65f8","type":"text","conversion_output":true,"text":"In addition to early detection of fungal infections, there also is interest in identifying children particularly","text_display":"\n\nIn addition to early detection of fungal infections, there also is interest in identifying children particularly","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fdeb71bc854c451d9c9a902fb059d195","type":"text","conversion_output":true,"text":"susceptible to these infections. There is considerable evidence that there is a genetic component to the","text_display":" susceptible to these infections. There is considerable evidence that there is a genetic component to the","confidence":1,"confidence_rate":1},{"cnt":[[245,380],[1880,380],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":380,"width":1636,"height":52},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7c28f26ede740a7ae1d434e10ad321b","type":"text","conversion_output":true,"text":"susceptibility and outcome of infection in both normal and immunocompromised populations. \\({ }^{38,39}\\) For","text_display":" susceptibility and outcome of infection in both normal and immunocompromised populations. \\({ }^{38,39}\\) For","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1880,425],[1880,473],[245,473]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":48},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b734819c269404bb632e1a4947f7087","type":"text","conversion_output":true,"text":"example, a study using a Danish adoption registry found that premature death from infection is much","text_display":" example, a study using a Danish adoption registry found that premature death from infection is much","confidence":1,"confidence_rate":1},{"cnt":[[245,468],[1880,468],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":468,"width":1636,"height":50},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e3444e52a08449f89508e9679f33364","type":"text","conversion_output":true,"text":"more heritable compared to premature death from cardiovascular disease or cancer. \\({ }^{40}\\) Redundancy in the","text_display":" more heritable compared to premature death from cardiovascular disease or cancer. \\({ }^{40}\\) Redundancy in the","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1884,511],[1884,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1641,"height":50},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fd3c697c3424af0b95eb04373b5b64b","type":"text","conversion_output":true,"text":"immune system may be important for protection against serious infection and in the face of","text_display":" immune system may be important for protection against serious infection and in the face of","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f74c3ced6a34c5297870764d7d9a9dd","type":"text","conversion_output":true,"text":"immunosuppression, defects in redundant pathways may be uncovered, leading to invasive bacterial or","text_display":" immunosuppression, defects in redundant pathways may be uncovered, leading to invasive bacterial or","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1880,602],[1880,647],[245,647]],"region":{"top_left_x":244,"top_left_y":601,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9aa15cc2f095419488c6d2234d055bd1","type":"text","conversion_output":true,"text":"fungal infections. \\({ }^{41,42}\\) While defects in immunity may contribute to susceptibility to infection and","text_display":" fungal infections. \\({ }^{41,42}\\) While defects in immunity may contribute to susceptibility to infection and","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1880,645],[1880,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1636,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79a9bdc148334615b4c944603ab2112d","type":"text","conversion_output":true,"text":"outcome, excessive inflammation during infection may also contribute to septic shock and mortality. \\({ }^{43}\\)","text_display":" outcome, excessive inflammation during infection may also contribute to septic shock and mortality. \\({ }^{43}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1878,692],[1878,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1634,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f434c196a233461c882de3b229a05c8b","type":"text","conversion_output":true,"text":"Thus, variation in immunity and inflammatory genes likely plays a role in an individual's susceptibility,","text_display":" Thus, variation in immunity and inflammatory genes likely plays a role in an individual's susceptibility,","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1882,735],[1882,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1639,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b7a9d6122b74979ad91c82266952f16","type":"text","conversion_output":true,"text":"response and prognosis related to infection. There is evidence specifically to link SNPs and the risk of","text_display":" response and prognosis related to infection. There is evidence specifically to link SNPs and the risk of","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1880,778],[1880,823],[245,823]],"region":{"top_left_x":244,"top_left_y":777,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8db5be366a4438e8bb1aa62e6d53081","type":"text","conversion_output":true,"text":"fungal infections. For example, Choi and colleagues found that 2 polymorphisms in IL-4 were associated","text_display":" fungal infections. For example, Choi and colleagues found that 2 polymorphisms in IL-4 were associated","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1880,821],[1880,868],[245,868]],"region":{"top_left_x":244,"top_left_y":820,"width":1636,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d51a4ae80add4240b83944fd78f7ac13","type":"text","conversion_output":true,"text":"with chronic disseminated candidiasis in patients with acute leukemia. \\({ }^{42}\\) In addition, a polymorphism in","text_display":" with chronic disseminated candidiasis in patients with acute leukemia. \\({ }^{42}\\) In addition, a polymorphism in","confidence":1,"confidence_rate":1},{"cnt":[[245,864],[1880,864],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":863,"width":1636,"height":51},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"728ef8a353494b768835be9743537132","type":"text","conversion_output":true,"text":"DEF \\(\\beta\\) was associated with Candida carriage in type 1 diabetes. \\({ }^{44}\\) Based on these and other studies, we","text_display":" DEF \\(\\beta\\) was associated with Candida carriage in type 1 diabetes. \\({ }^{44}\\) Based on these and other studies, we","confidence":0.5533874034881592,"confidence_rate":0.9952010076342955},{"cnt":[[245,909],[1800,909],[1800,956],[245,956]],"region":{"top_left_x":244,"top_left_y":908,"width":1557,"height":49},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0516736fb94d443ca5f0af07bf27c4b9","type":"text","conversion_output":true,"text":"propose to test for associations between genetic variants in genes mediating innate immunity and IFI.","text_display":" propose to test for associations between genetic variants in genes mediating innate immunity and IFI.","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[236,1036],[1326,1036],[1326,1091],[236,1091]],"region":{"top_left_x":236,"top_left_y":1035,"width":1090,"height":57},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6f9853a586e4abea89f37c402202015","type":"section_header","conversion_output":false,"children_ids":["f6e46ee9a21d4156861b4d3987847ac6"],"text":"","text_display":""},{"cnt":[[245,1040],[1319,1040],[1319,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1039,"width":1076,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6e46ee9a21d4156861b4d3987847ac6","type":"text","conversion_output":true,"parent_id":"e6f9853a586e4abea89f37c402202015","text":"3.0 STUDY ENROLLMENT AND PATIENT ELIGIBILITY","text_display":"\n\n\\subsection*{3.0 STUDY ENROLLMENT AND PATIENT ELIGIBILITY}","confidence":1,"confidence_rate":1},{"cnt":[[241,1113],[681,1113],[681,1171],[241,1171]],"region":{"top_left_x":240,"top_left_y":1112,"width":442,"height":59},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0030cc7f4a24a179f43e8b01aa3013a","type":"section_header","conversion_output":false,"children_ids":["3a25b9e0dd9f4e82a5c66be3948a924d"],"text":"","text_display":""},{"cnt":[[245,1117],[672,1117],[672,1164],[245,1164]],"region":{"top_left_x":244,"top_left_y":1117,"width":429,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a25b9e0dd9f4e82a5c66be3948a924d","type":"text","conversion_output":true,"parent_id":"e0030cc7f4a24a179f43e8b01aa3013a","text":"3.1 Study Enrollment","text_display":"\n\n\\subsection*{3.1 Study Enrollment}","confidence":1,"confidence_rate":1},{"cnt":[[241,1186],[690,1186],[690,1244],[241,1244]],"region":{"top_left_x":240,"top_left_y":1185,"width":450,"height":59},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18ad2154ebe044b2be23025dd62af601","type":"section_header","conversion_output":false,"children_ids":["94752fb37aa14248a54949c3e78bf40c"],"text":"","text_display":""},{"cnt":[[245,1195],[683,1195],[683,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1194,"width":440,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94752fb37aa14248a54949c3e78bf40c","type":"text","conversion_output":true,"parent_id":"18ad2154ebe044b2be23025dd62af601","text":"3.1.1 Patient Registration","text_display":"\n\n\\subsection*{3.1.1 Patient Registration}","confidence":1,"confidence_rate":1},{"cnt":[[245,1238],[1880,1238],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1237,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5319fa13c9b5475e9f7bf31c83cb039f","type":"text","conversion_output":true,"text":"Prior to enrollment on this study, patients must be assigned a COG patient ID number. 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The COG patient ID number is used to identify the patient in all future interactions with","text_display":" been obtained. The COG patient ID number is used to identify the patient in all future interactions with","confidence":1,"confidence_rate":1},{"cnt":[[245,1366],[1476,1366],[1476,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1366,"width":1232,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e96c2fc839049a9a95dc9a3e5b63ffa","type":"text","conversion_output":true,"text":"COG. If you have problems with the registration, please refer to the online help.","text_display":" COG. 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For Time of Need registrations, in addition to marking your submissions as","text_display":" Need\" registration. 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The clinical significance of the above effects is","text_display":" fluconazole can induce the metabolism of these drugs. 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(TDM) for fluconazole prophylaxis is on the next page.","text_display":"\n\nThe therapy delivery map (TDM) for fluconazole prophylaxis is on the next page.","confidence":1,"confidence_rate":1},{"cnt":[[245,2161],[1880,2161],[1880,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2161,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70b918b69a7c491db354ef36efcb2a4f","type":"text","conversion_output":true,"text":"Following completion of prophylaxis in each course of chemotherapy, prophylaxis will restart at the end","text_display":"\nFollowing completion of prophylaxis in each course of chemotherapy, prophylaxis will restart at the 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04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1880,2582],[1880,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":132,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cc70c054f354832ad6562795678f188","type":"page_info","conversion_output":false,"text":"Page 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Fluconazole Treatment Arm. \\\\\nPatients randomized to fluconazole arm.\n\\end{tabular}","cell_row":0,"cell_column":0,"cell_row_span":2,"cell_col_span":1},{"cnt":[[107,294],[741,294],[741,385],[107,385]],"region":{"top_left_x":106,"top_left_y":293,"width":636,"height":92},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3357b9c815744a2a1862a53b60dad2b","type":"complex_cell","conversion_output":false,"parent_id":"c200c00986eb441c80172790a69f6957","children_ids":["b8747387ee6e4ed9ac6e4683a04d7b2d","f059a732987e487ea6be6a566cb1a86c"],"text":"\\begin{tabular}{l}\n4.2.1. Fluconazole Treatment Arm. \\\\\nPatients randomized to fluconazole arm.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n4.2.1. Fluconazole Treatment Arm. \\\\\nPatients randomized to fluconazole arm.\n\\end{tabular}","cell_row":0,"cell_column":0,"cell_row_span":2,"cell_col_span":1,"confidence":0.9931640625,"confidence_rate":0.9999097486840676},{"cnt":[[113,298],[692,298],[692,339],[113,339]],"region":{"top_left_x":113,"top_left_y":297,"width":579,"height":43},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8747387ee6e4ed9ac6e4683a04d7b2d","type":"text","conversion_output":false,"parent_id":"d3357b9c815744a2a1862a53b60dad2b","text":"4.2.1. Fluconazole Treatment Arm.","text_display":"4.2.1. 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CBC, diff, plts, creatinine, SGPT, SGOT, bilirubin \\\\\nb. IFI Checklist (see Section 10.2) \\\\\nOptional: \\\\\nc. Galactomannan and beta-D glucan testing \\\\\nd. SNP \\\\\nOBTAIN OTHER STUDIES AS \\\\\nREQUIRED FOR GOOD \\\\\nPATIENT CARE\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline FLUCONAZOLE & Slow IV infusion over 1-2 hours* (or longer) OR by mouth. & \\begin{tabular}{l}\n\\(\\geq 3\\) months - 17.99 years: \\(12 mg / kg /\\) day (IV or enteral dose) \\\\\nMaximum dose: \\(4 0 0 ~ m g / d a y\\) \\\\\n18-30 years: \\(6 mg / kg /\\) day (IV or enteral dose) \\\\\nMaximum dose: \\(4 0 0 ~ m g / d a y\\)\n\\end{tabular} & Once daily & \\begin{tabular}{l}\nStart within 24-72 hours following completion of each systemic chemotherapy course. \\\\\n*For IV: The infusion rate should not exceed 200 mg /hour. \\\\\nSee Section 4.2 for oral drug administration.\n\\end{tabular} & \\begin{tabular}{l}\na. CBC, diff, plts, creatinine, SGPT, SGOT, bilirubin \\\\\nb. 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DOSE MODIFICATIONS FOR TOXICITIES","text_display":"\n\n\\subsection*{5.0 DOSE MODIFICATIONS FOR TOXICITIES}","confidence":1,"confidence_rate":1},{"cnt":[[241,331],[797,331],[797,389],[241,389]],"region":{"top_left_x":240,"top_left_y":330,"width":558,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70c2d7870a56408288eaecc49ddc7fa8","type":"section_header","conversion_output":false,"children_ids":["53388a036e084bf4bdf1eeef01f96379"],"text":"","text_display":""},{"cnt":[[245,337],[793,337],[793,385],[245,385]],"region":{"top_left_x":244,"top_left_y":337,"width":549,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53388a036e084bf4bdf1eeef01f96379","type":"text","conversion_output":true,"parent_id":"70c2d7870a56408288eaecc49ddc7fa8","text":"5.1 Impaired Renal Function","text_display":"\n\n\\subsection*{5.1 Impaired Renal Function}","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1880,382],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1636,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68ecff3c14464a9391af862e689fc666","type":"text","conversion_output":true,"text":"When estimating renal function for adjusting drug doses, use the Schwartz formula for patients \\(<18\\) years","text_display":"\n\nWhen estimating renal function for adjusting drug doses, use the Schwartz formula for patients \\(<18\\) years","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[245,425],[1396,425],[1396,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1153,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fcd39e1776343ffa71050c38e6f2515","type":"text","conversion_output":true,"text":"of age and the Cockcroft and Gault equation for patients \\(\\geq 18\\) years of age.","text_display":" of age and the Cockcroft and Gault equation for patients \\(\\geq 18\\) years of age.","confidence":1,"confidence_rate":1},{"cnt":[[236,507],[466,507],[466,561],[236,561]],"region":{"top_left_x":236,"top_left_y":507,"width":231,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec14c2b8692442f0820262a5868cf873","type":"section_header","conversion_output":false,"children_ids":["676cdc9bcd414e089da8bceda568eef0"],"text":"","text_display":""},{"cnt":[[245,516],[462,516],[462,556],[245,556]],"region":{"top_left_x":244,"top_left_y":515,"width":218,"height":42},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"676cdc9bcd414e089da8bceda568eef0","type":"text","conversion_output":true,"parent_id":"ec14c2b8692442f0820262a5868cf873","text":"Fluconazole:","text_display":"\n\n\\section*{Fluconazole:}","confidence":1,"confidence_rate":1},{"cnt":[[223,552],[1901,552],[1901,836],[223,836]],"region":{"top_left_x":223,"top_left_y":552,"width":1679,"height":284},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5a6c2e89b5a45aab7501ca89e631f42","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline \\multirow{2}{*}{\\begin{tabular}{l} \nCreatinine clearance \\\\\n\\(\\left( mL / min / 1.73 m^{2}\\right)\\)\n\\end{tabular}} & \\multirow{2}{*}{ Percent of dose } & \\multicolumn{2}{|c|}{ Dose in mg/kg (max dose) } \\\\\n\\cline { 3 - 4 } & & \\(\\geq 3 ~ m o n t h s\\) to 17.99 years: & \\(\\geq 1 8\\) years to 30 years: \\\\\n\\hline\\(>50\\) & \\(100 \\%\\) & \\(12 mg / kg ( max 400 mg )\\) & \\(6 mg / kg ( max 400 mg )\\) \\\\\n\\hline\\(\\leq 50( no\\) dialysis \\()\\) & \\(50 \\%\\) & \\(6 mg / kg ( max 200 mg )\\) & \\(3 mg / kg ( max 200 mg )\\) \\\\\n\\hline Hemodialysis & \\begin{tabular}{l}\n\\(100 \\%\\) after each \\\\\ndialysis\n\\end{tabular} & \\begin{tabular}{l}\n\\(12 mg / kg ( max 400 mg\\) \\\\\nafter each dialysis \\()\\)\n\\end{tabular} & \\begin{tabular}{l}\n\\(6 mg / kg ( max 400 mg\\) \\\\\nafter each dialysis \\()\\)\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|}\n\\hline \\multirow{2}{*}{\\begin{tabular}{l} \nCreatinine clearance \\\\\n\\(\\left( mL / min / 1.73 m^{2}\\right)\\)\n\\end{tabular}} & \\multirow{2}{*}{ Percent of dose } & \\multicolumn{2}{|c|}{ Dose in mg/kg (max dose) } \\\\\n\\cline { 3 - 4 } & & \\(\\geq 3 ~ m o n t h s\\) to 17.99 years: & \\(\\geq 1 8\\) years to 30 years: \\\\\n\\hline\\(>50\\) & \\(100 \\%\\) & \\(12 mg / kg ( max 400 mg )\\) & \\(6 mg / kg ( max 400 mg )\\) \\\\\n\\hline\\(\\leq 50( no\\) dialysis \\()\\) & \\(50 \\%\\) & \\(6 mg / kg ( max 200 mg )\\) & \\(3 mg / kg ( max 200 mg )\\) \\\\\n\\hline Hemodialysis & \\begin{tabular}{l}\n\\(100 \\%\\) after each \\\\\ndialysis\n\\end{tabular} & \\begin{tabular}{l}\n\\(12 mg / kg ( max 400 mg\\) \\\\\nafter each dialysis \\()\\)\n\\end{tabular} & \\begin{tabular}{l}\n\\(6 mg / kg ( max 400 mg\\) \\\\\nafter each dialysis \\()\\)\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.07451281115164897,"confidence_rate":0.9957933142183416},{"cnt":[[243,872],[1850,872],[1850,922],[243,922]],"region":{"top_left_x":242,"top_left_y":872,"width":1608,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b60dee689d1e4b0797ec5c735f177df8","type":"text","conversion_output":true,"text":"Note: When renal function improves to \\(>50 mL / min / 1.73 m^{2}\\), the dose can be increased to the full dose.","text_display":"\n\nNote: When renal function improves to \\(>50 mL / min / 1.73 m^{2}\\), the dose can be increased to the full dose.","confidence":0.9980475902557373,"confidence_rate":0.9999842394937093},{"cnt":[[241,956],[479,956],[479,1016],[241,1016]],"region":{"top_left_x":240,"top_left_y":956,"width":240,"height":61},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"674704215afa47fc93c708eb099fed5b","type":"section_header","conversion_output":false,"children_ids":["fadd1ec8458a4262bec6950ccaf78a9a"],"text":"","text_display":""},{"cnt":[[245,962],[473,962],[473,1010],[245,1010]],"region":{"top_left_x":244,"top_left_y":962,"width":229,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fadd1ec8458a4262bec6950ccaf78a9a","type":"text","conversion_output":true,"parent_id":"674704215afa47fc93c708eb099fed5b","text":"Caspofungin:","text_display":"\n\n\\section*{Caspofungin:}","confidence":1,"confidence_rate":1},{"cnt":[[245,1005],[1882,1005],[1882,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1005,"width":1639,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95be4c26763d445aba52acc62168f53e","type":"text","conversion_output":true,"text":"Adjustment of the dose is not needed in the setting of impaired renal function. Caspofungin is not","text_display":"\n\nAdjustment of the dose is not needed in the setting of impaired renal function. Caspofungin is not","confidence":0.9990234375,"confidence_rate":0.9999905142231666},{"cnt":[[245,1051],[1347,1051],[1347,1098],[245,1098]],"region":{"top_left_x":244,"top_left_y":1050,"width":1104,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff0e8a964657457492fc3d3c7dfdb954","type":"text","conversion_output":true,"text":"dialyzable and supplementation is not required following hemodialysis.","text_display":" dialyzable and supplementation is not required following hemodialysis.","confidence":1,"confidence_rate":1},{"cnt":[[241,1130],[795,1130],[795,1192],[241,1192]],"region":{"top_left_x":240,"top_left_y":1130,"width":555,"height":63},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17b6f3b56ed74887ba3c8d309185d5f3","type":"section_header","conversion_output":false,"children_ids":["00525686de814217ae33194a2acf81fe"],"text":"","text_display":""},{"cnt":[[245,1137],[788,1137],[788,1188],[245,1188]],"region":{"top_left_x":244,"top_left_y":1136,"width":545,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00525686de814217ae33194a2acf81fe","type":"text","conversion_output":true,"parent_id":"17b6f3b56ed74887ba3c8d309185d5f3","text":"5.2 Impaired Liver Function","text_display":"\n\n\\subsection*{5.2 Impaired Liver Function}","confidence":0.99951171875,"confidence_rate":0.9999847376009057},{"cnt":[[241,1220],[466,1220],[466,1274],[241,1274]],"region":{"top_left_x":240,"top_left_y":1220,"width":227,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bc4d16f92be464fb7785eaa87539c76","type":"section_header","conversion_output":false,"children_ids":["e0933f66d7b24c11a3d05eaf0aea0157"],"text":"","text_display":""},{"cnt":[[245,1229],[462,1229],[462,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1228,"width":218,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0933f66d7b24c11a3d05eaf0aea0157","type":"text","conversion_output":true,"parent_id":"0bc4d16f92be464fb7785eaa87539c76","text":"Fluconazole:","text_display":"\n\n\\section*{Fluconazole:}","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1880,1268],[1880,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1267,"width":1636,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2ae8c37d98c4b419e31ce2451545ea1","type":"text","conversion_output":true,"text":"Fluconazole should be held in patients who develop signs and symptoms consistent with liver disease or","text_display":"\n\nFluconazole should be held in patients who develop signs and symptoms consistent with liver disease or","confidence":1,"confidence_rate":1},{"cnt":[[245,1315],[1880,1315],[1880,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1314,"width":1636,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6e83d3efb2f45c39c1f1194106ed782","type":"text","conversion_output":true,"text":"elevations in hepatic function tests as defined by an ALT or AST \\(>5 x\\) ULN or serum bilirubin \\(>2 x\\)","text_display":" elevations in hepatic function tests as defined by an ALT or AST \\(>5 x\\) ULN or serum bilirubin \\(>2 x\\)","confidence":0.7247436046600342,"confidence_rate":0.9970235372209336},{"cnt":[[245,1358],[342,1358],[342,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1357,"width":98,"height":42},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a112438b8544d2ab6482a0cb6ec79cc","type":"text","conversion_output":true,"text":"ULN.","text_display":" ULN.","confidence":1,"confidence_rate":1},{"cnt":[[241,1439],[490,1439],[490,1500],[241,1500]],"region":{"top_left_x":240,"top_left_y":1439,"width":250,"height":61},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7a70031fcdb48d3a2776b30d1ad2e9a","type":"section_header","conversion_output":false,"children_ids":["47d19b1bcbcb4dcf8f93b5423cf70f2b"],"text":"","text_display":""},{"cnt":[[245,1448],[475,1448],[475,1493],[245,1493]],"region":{"top_left_x":244,"top_left_y":1448,"width":231,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47d19b1bcbcb4dcf8f93b5423cf70f2b","type":"text","conversion_output":true,"parent_id":"c7a70031fcdb48d3a2776b30d1ad2e9a","text":"Caspofungin:","text_display":"\n\n\\section*{Caspofungin:}","confidence":1,"confidence_rate":1},{"cnt":[[245,1491],[492,1491],[492,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1491,"width":248,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b13f499a9e0a44cf915e19dd6f18c766","type":"text","conversion_output":true,"text":"For all patients:","text_display":"\n\nFor all patients:","confidence":1,"confidence_rate":1},{"cnt":[[226,1525],[1899,1525],[1899,1854],[226,1854]],"region":{"top_left_x":225,"top_left_y":1525,"width":1675,"height":330},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6895ea39fcd44e0a6c0badc29921a17","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\begin{tabular}{l} \nChild - Pugh \\\\\nscore\n\\end{tabular}\\(|\\) & Percent of dose & Dose in mg/kg (max dose) \\\\\n\\hline Mild (5-6) & \\(100 \\%\\) & \\begin{tabular}{l} \nLoading dose: \\(70 mg / m ^{2} /\\) dose \\((\\max 70 mg )\\) \\\\\nMaintenance dose: \\(50 mg / m ^{2} /\\) dose \\((\\max 50 mg )\\)\n\\end{tabular} \\\\\n\\hline Moderate \\((7-9)\\) & \\begin{tabular}{l} \nLoading dose-100\\% \\\\\nMaintenance dose- \\(70 \\%\\)\n\\end{tabular} & \\begin{tabular}{l} \nLoading dose: \\(70 mg / m ^{2} /\\) dose \\((\\max 70 mg )\\) \\\\\nMaintenance dose: \\(35 mg / m ^{2} /\\) dose \\((\\max 35 mg )\\)\n\\end{tabular} \\\\\n\\hline Severe \\((>9)\\) & Hold & Hold \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\begin{tabular}{l} \nChild - Pugh \\\\\nscore\n\\end{tabular}\\(|\\) & Percent of dose & Dose in mg/kg (max dose) \\\\\n\\hline Mild (5-6) & \\(100 \\%\\) & \\begin{tabular}{l} \nLoading dose: \\(70 mg / m ^{2} /\\) dose \\((\\max 70 mg )\\) \\\\\nMaintenance dose: \\(50 mg / m ^{2} /\\) dose \\((\\max 50 mg )\\)\n\\end{tabular} \\\\\n\\hline Moderate \\((7-9)\\) & \\begin{tabular}{l} \nLoading dose-100\\% \\\\\nMaintenance dose- \\(70 \\%\\)\n\\end{tabular} & \\begin{tabular}{l} \nLoading dose: \\(70 mg / m ^{2} /\\) dose \\((\\max 70 mg )\\) \\\\\nMaintenance dose: \\(35 mg / m ^{2} /\\) dose \\((\\max 35 mg )\\)\n\\end{tabular} \\\\\n\\hline Severe \\((>9)\\) & Hold & Hold \\\\\n\\hline\n\\end{tabular}","confidence":0.046070826124915615,"confidence_rate":0.994399726878066},{"cnt":[[245,1891],[793,1891],[793,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1890,"width":549,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfb88248ae99468b8efdddd4b4e4472c","type":"text","conversion_output":true,"text":"To calculate the Child-Pugh Score:","text_display":"\n\nTo calculate the Child-Pugh 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In healthy adults","confidence":1,"confidence_rate":1},{"cnt":[[245,2131],[1880,2131],[1880,2181],[245,2181]],"region":{"top_left_x":244,"top_left_y":2131,"width":1636,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f12557fe03914f0a97243a19d20c4a00","type":"text","conversion_output":true,"text":"receiving 50 - or \\(100- mg\\) doses of fluconazole given once daily by IV infusion over 30 minutes, serum","text_display":" receiving 50 - or \\(100- mg\\) doses of fluconazole given once daily by IV infusion over 30 minutes, serum","confidence":0.9791073342785239,"confidence_rate":0.9998195546940664},{"cnt":[[245,2179],[1880,2179],[1880,2228],[245,2228]],"region":{"top_left_x":244,"top_left_y":2178,"width":1636,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9ac2290f88f4e3ea396203808cfee82","type":"text","conversion_output":true,"text":"concentrations of the drug 1 hour after dosing on the sixth or seventh day of therapy ranged from 2.14-","text_display":" concentrations of the drug 1 hour after dosing on the sixth or seventh day of therapy ranged from 2.14","confidence":0.9931640625,"confidence_rate":0.9999382054269228},{"cnt":[[245,2226],[1880,2226],[1880,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2225,"width":1636,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cbc4d5fffa24deaa51add097b8dfcf4","type":"text","conversion_output":true,"text":"2.81 or \\(3.86-4.96 mcg / mL\\), respectively. In a multiple-dose study in children \\(5-15\\) years of age, IV","text_display":"2.81 or \\(3.86-4.96 mcg / mL\\), respectively. In a multiple-dose study in children \\(5-15\\) years of age, IV","confidence":0.7877011299133301,"confidence_rate":0.9979088864672678},{"cnt":[[245,2273],[1884,2273],[1884,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2273,"width":1641,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f716c879e223481db6b64cf894901fe5","type":"text","conversion_output":true,"text":"administration of \\(2-\\), \\(4-\\), or \\(8- mg / kg\\) doses of fluconazole resulted in mean peak plasma concentrations of","text_display":" administration of \\(2-\\), \\(4-\\), or \\(8- mg / kg\\) doses of fluconazole resulted in mean peak plasma concentrations of","confidence":0.6186469690874219,"confidence_rate":0.9961959799271483},{"cnt":[[245,2322],[1880,2322],[1880,2374],[245,2374]],"region":{"top_left_x":244,"top_left_y":2322,"width":1636,"height":53},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f8a3b589c91405192ab85ba24520ecc","type":"text","conversion_output":true,"text":"\\(5.5,11.4\\), or \\(14.1 mcg / mL\\), respectively. Fluconazole is widely distributed into body tissues and fluids","text_display":" \\(5.5,11.4\\), or \\(14.1 mcg / mL\\), respectively. Fluconazole is widely distributed into body tissues and fluids","confidence":0.9990236759185791,"confidence_rate":0.9999915793372107},{"cnt":[[245,2372],[1880,2372],[1880,2419],[245,2419]],"region":{"top_left_x":244,"top_left_y":2371,"width":1636,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9b28cd2e1f84364ae964acc7e7e2783","type":"text","conversion_output":true,"text":"following oral or IV administration. In adult humans with normal renal function, concentrations of the","text_display":" following oral or IV administration. In adult humans with normal renal function, concentrations of the","confidence":1,"confidence_rate":1},{"cnt":[[245,2419],[1880,2419],[1880,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2419,"width":1636,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"695832e12ff74b33947537f9858217f2","type":"text","conversion_output":true,"text":"drug in urine and skin may be 10 times higher than concurrent plasma concentrations. Concentrations in","text_display":" drug in urine and skin may be 10 times higher than concurrent plasma concentrations. Concentrations in","confidence":0.99609375,"confidence_rate":0.9999644197300734},{"cnt":[[245,2582],[612,2582],[612,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":369,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3335a4d6610844b2a2f4019ed5acbf3f","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1876,2582],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":128,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbdd52796c1b4adf97b76ba4de1f2b3c","type":"page_info","conversion_output":false,"text":"Page 23","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"30d0fca4-08d7-48bb-b63f-1324b67d52fd-24","page":24,"lines":[{"cnt":[[262,88],[436,88],[436,122],[262,122]],"region":{"top_left_x":262,"top_left_y":88,"width":175,"height":35},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5bed43f0baf14a38b6def215f8a01106","type":"page_info","conversion_output":false,"text":"CHILDREN'S","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,120],[415,120],[415,157],[262,157]],"region":{"top_left_x":262,"top_left_y":120,"width":153,"height":37},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"099a31261d4f4a0ea1744509e3a4f9fb","type":"page_info","conversion_output":false,"text":"ONCOLOGY","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[494,131],[1497,131],[1497,170],[494,170]],"region":{"top_left_x":494,"top_left_y":131,"width":1004,"height":39},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"48722700bc46492e94e018ed489e91e9","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.8456400741124526,"confidence_rate":0.9979064264110613},{"cnt":[[1691,125],[1880,125],[1880,165],[1691,165]],"region":{"top_left_x":1690,"top_left_y":124,"width":190,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6435138a1034979b91df16499d4dc19","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[363,155],[363,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":102,"height":38},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a227e15976e4434b7040156056e15ed","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,254],[1880,254],[1880,303],[245,303]],"region":{"top_left_x":244,"top_left_y":253,"width":1636,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0be727b27c494bd89eb16caa44219222","type":"text","conversion_output":true,"text":"saliva, sputum, nails, blister fluid, blister skin, and vaginal tissue are approximately equal to concurrent","text_display":"\nsaliva, sputum, nails, blister fluid, blister skin, and vaginal tissue are approximately equal to concurrent","confidence":1,"confidence_rate":1},{"cnt":[[245,301],[1880,301],[1880,350],[245,350]],"region":{"top_left_x":244,"top_left_y":300,"width":1636,"height":51},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df4b6d03590348f7aa7a2bfa64cedacf","type":"text","conversion_output":true,"text":"plasma concentrations. Fluconazole, unlike some azole-derivative antifungal agents (e.g., itraconazole,","text_display":" plasma concentrations. Fluconazole, unlike some azole-derivative antifungal agents (e.g., itraconazole,","confidence":1,"confidence_rate":1},{"cnt":[[245,348],[1880,348],[1880,397],[245,397]],"region":{"top_left_x":244,"top_left_y":348,"width":1636,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3567a14dabf048bca56e48eeae42de71","type":"text","conversion_output":true,"text":"ketoconazole), distributes readily into the CSF following oral or IV administration. Another difference","text_display":" ketoconazole), distributes readily into the CSF following oral or IV administration. Another difference","confidence":1,"confidence_rate":1},{"cnt":[[245,397],[1880,397],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":397,"width":1636,"height":53},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b95e73d8516648ff87cff972d4ffc661","type":"text","conversion_output":true,"text":"from other azole-derivative antifungals (e.g., itraconazole, ketoconazole, miconazole), is that fluconazole","text_display":" from other azole-derivative antifungals (e.g., itraconazole, ketoconazole, miconazole), is that fluconazole","confidence":1,"confidence_rate":1},{"cnt":[[245,447],[1783,447],[1783,494],[245,494]],"region":{"top_left_x":244,"top_left_y":446,"width":1540,"height":49},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d8aba0331544e2584afa2ba5414d80d","type":"text","conversion_output":true,"text":"is only \\(11-12 \\%\\) bound to plasma proteins while the other azole derivatives are highly protein bound.","text_display":" is only \\(11-12 \\%\\) bound to plasma proteins while the other azole derivatives are highly protein bound.","confidence":0.99169921875,"confidence_rate":0.999922101869927},{"cnt":[[245,533],[1880,533],[1880,582],[245,582]],"region":{"top_left_x":244,"top_left_y":532,"width":1636,"height":51},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b87a1f27b5b47cf9fcaef2b45795fe0","type":"text","conversion_output":true,"text":"The plasma elimination half-life of fluconazole in adults with normal renal function is approximately","text_display":"\n\nThe plasma elimination half-life of fluconazole in adults with normal renal function is approximately","confidence":1,"confidence_rate":1},{"cnt":[[245,578],[1880,578],[1880,625],[245,625]],"region":{"top_left_x":244,"top_left_y":577,"width":1636,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b8f93ebb62c40409226129a00ae2fe7","type":"text","conversion_output":true,"text":"30 hours (range: 20-50 hours). The mean plasma half-life of fluconazole in children 5 to 15 years of age","text_display":" 30 hours (range: 20-50 hours). The mean plasma half-life of fluconazole in children 5 to 15 years of age","confidence":0.9520732155069709,"confidence_rate":0.9995692740162501},{"cnt":[[245,623],[1880,623],[1880,668],[245,668]],"region":{"top_left_x":244,"top_left_y":623,"width":1636,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"081733bc02b5494e823de503c1f90a44","type":"text","conversion_output":true,"text":"after multiple IV doses is at the range of 15-18 hours. In healthy adults, fluconazole is eliminated mainly","text_display":" after multiple IV doses is at the range of 15-18 hours. In healthy adults, fluconazole is eliminated mainly","confidence":0.9306640625,"confidence_rate":0.9993586262864537},{"cnt":[[245,666],[1882,666],[1882,713],[245,713]],"region":{"top_left_x":244,"top_left_y":666,"width":1639,"height":48},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7882f6e92be24ab582a9e462f022b9aa","type":"text","conversion_output":true,"text":"by renal excretion with approximately \\(80 \\%\\) excreted in the urine as unchanged drug. Small amounts of","text_display":" by renal excretion with approximately \\(80 \\%\\) excreted in the urine as unchanged drug. Small amounts of","confidence":1,"confidence_rate":1},{"cnt":[[245,709],[1880,709],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1636,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6152d70fbcb7427ebd82c3aab5ace0bc","type":"text","conversion_output":true,"text":"the drug are excreted in feces. Metabolism accounts for only \\(11 \\%\\) of total drug excreted. The renal","text_display":" the drug are excreted in feces. Metabolism accounts for only \\(11 \\%\\) of total drug excreted. The renal","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1880,752],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c3e7314df3047db88967e932ec806a6","type":"text","conversion_output":true,"text":"clearance rate in adults is 0.27 to \\(0.63 mL / min / kg\\) and in children age 5 to 15 years it is 0.4 to","text_display":" clearance rate in adults is 0.27 to \\(0.63 mL / min / kg\\) and in children age 5 to 15 years it is 0.4 to","confidence":0.9965856060155147,"confidence_rate":0.9999726384836921},{"cnt":[[245,799],[509,799],[509,844],[245,844]],"region":{"top_left_x":244,"top_left_y":799,"width":266,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd31aebbbd1f4b8ba3758fb32ac4337e","type":"text","conversion_output":true,"text":"\\(0.66 mL / min / kg\\).","text_display":" \\(0.66 mL / min / kg\\).","confidence":0.998046875,"confidence_rate":0.9999301797648388},{"cnt":[[245,889],[1880,889],[1880,939],[245,939]],"region":{"top_left_x":244,"top_left_y":889,"width":1636,"height":50},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e7032b8ae604858b31ac544b277abef","type":"text","conversion_output":true,"text":"Some azoles, including fluconazole, have been associated with prolongation of the QT interval on the","text_display":"\n\nSome azoles, including fluconazole, have been associated with prolongation of the QT interval on the","confidence":1,"confidence_rate":1},{"cnt":[[245,937],[1880,937],[1880,986],[245,986]],"region":{"top_left_x":244,"top_left_y":936,"width":1636,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"054879096d904d7dbd88083ce249bcf8","type":"text","conversion_output":true,"text":"electrocardiogram. Fluconazole should be administered with caution to patients with this potentially","text_display":" electrocardiogram. Fluconazole should be administered with caution to patients with this potentially","confidence":1,"confidence_rate":1},{"cnt":[[245,986],[1880,986],[1880,1036],[245,1036]],"region":{"top_left_x":244,"top_left_y":986,"width":1636,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00bea8b0e37c43b88deec72691b299e8","type":"text","conversion_output":true,"text":"proarrhythmic condition. Clinically or potentially significant drug interactions between fluconazole and","text_display":" proarrhythmic condition. Clinically or potentially significant drug interactions between fluconazole and","confidence":1,"confidence_rate":1},{"cnt":[[245,1033],[1876,1033],[1876,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1033,"width":1632,"height":52},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1e5b614c1f143df87258ef5bbf48163","type":"text","conversion_output":true,"text":"the following agents/classes have been observed: oral hypoglycemics (tolbutamide, glyburide, glipizide),","text_display":" the following agents/classes have been observed: oral hypoglycemics (tolbutamide, glyburide, glipizide),","confidence":1,"confidence_rate":1},{"cnt":[[245,1083],[1880,1083],[1880,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1082,"width":1636,"height":51},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92c5aedc487f4488b2bbe52e66a08a6b","type":"text","conversion_output":true,"text":"coumarin-type anticoagulants (e.g., warfarin), phenytoin, cyclosporine, rifampin, theophylline,","text_display":" coumarin-type anticoagulants (e.g., warfarin), phenytoin, cyclosporine, rifampin, theophylline,","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1880,1130],[1880,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1130,"width":1636,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33bff203c5e94dc8869c487072914cdd","type":"text","conversion_output":true,"text":"terfenadine, cisapride, astemizole, rifabutin, tacrolimus, short-acting benzodiazepines (more pronounced","text_display":" terfenadine, cisapride, astemizole, rifabutin, tacrolimus, short-acting benzodiazepines (more pronounced","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1880,1177],[1880,1227],[245,1227]],"region":{"top_left_x":244,"top_left_y":1177,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68baa90e6e5445718d7fd3a4150d7da4","type":"text","conversion_output":true,"text":"with oral fluconazole). Coadministration of oral fluconazole with combination contraceptives has resulted","text_display":" with oral fluconazole). Coadministration of oral fluconazole with combination contraceptives has resulted","confidence":1,"confidence_rate":1},{"cnt":[[245,1227],[1878,1227],[1878,1276],[245,1276]],"region":{"top_left_x":244,"top_left_y":1226,"width":1634,"height":51},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33030b77734e4dd793405865853df349","type":"text","conversion_output":true,"text":"in an overall mean increase in ethinyl estradiol and levonorgestrel levels. However, in some patients","text_display":" in an overall mean increase in ethinyl estradiol and levonorgestrel levels. However, in some patients","confidence":1,"confidence_rate":1},{"cnt":[[245,1274],[1880,1274],[1880,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1274,"width":1636,"height":52},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7228ea76696d4514ba82981eb601f1cd","type":"text","conversion_output":true,"text":"levels of ethinyl estradiol and levonorgestrel decreased by up to \\(47 \\%\\) and \\(33 \\%\\), respectively. The clinical","text_display":" levels of ethinyl estradiol and levonorgestrel decreased by up to \\(47 \\%\\) and \\(33 \\%\\), respectively. The clinical","confidence":0.99658203125,"confidence_rate":0.9999707369807385},{"cnt":[[245,1323],[1880,1323],[1880,1373],[245,1373]],"region":{"top_left_x":244,"top_left_y":1323,"width":1636,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0886647e4a064c7e9b2bbaa4fae9e38f","type":"text","conversion_output":true,"text":"significance of the above effects is currently undetermined and may simply be a product of interindividual","text_display":" significance of the above effects is currently undetermined and may simply be a product of interindividual","confidence":1,"confidence_rate":1},{"cnt":[[245,1371],[625,1371],[625,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1370,"width":382,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4713930b1b8749aaa66f33542762e8cf","type":"text","conversion_output":true,"text":"variation in metabolism.","text_display":" variation in metabolism.","confidence":1,"confidence_rate":1},{"cnt":[[243,1414],[402,1414],[402,1467],[243,1467]],"region":{"top_left_x":242,"top_left_y":1413,"width":160,"height":55},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6f8058e33d54432a152a1ddaba11309","type":"section_header","conversion_output":false,"children_ids":["975729b24a564d6583f85f8db2bb35bf"],"text":"","text_display":""},{"cnt":[[245,1418],[400,1418],[400,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1417,"width":156,"height":47},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"975729b24a564d6583f85f8db2bb35bf","type":"text","conversion_output":true,"parent_id":"d6f8058e33d54432a152a1ddaba11309","text":"Toxicity:","text_display":"\n\n\\section*{Toxicity:}","confidence":1,"confidence_rate":1},{"cnt":[[245,1454],[1882,1454],[1882,2479],[245,2479]],"region":{"top_left_x":244,"top_left_y":1454,"width":1639,"height":1026},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20c2f57d19de4e28870cf2de4a0be425","type":"table","conversion_output":true,"children_ids":["3df7cd3de0754d8184520ed724164640","480115aef85d4f27b0784fbb53e62a33","8ea10993bdcb4d9a9b4113625bb06057","eb8eafc54858429c8a2e52f3a86ac096","9c883b8e1e1040e68374d799934f4a13","dbda26ab02a14db2869ba98acd4d01ab","84e4cb5fffd94ef8999a2c08dee143b6","62ef7bb61a994fa89e35bad74e3e6b3d","8ae1e872e9e1483aa3d84357c8f7a9cb","0957ac5cce6c4650be3b969750280da6","3a73cee1044f440b9bce5e037bf0ce0d","e035d25b985a43d288572ac591b7c1c5","8c2302fcfec546d785c28a0657f38848","0c45d5df98504b1aaaf68acada811c20","cdd2d36855fa4c8bb31e48a416531e15","8974b47ab8c44a0c933a0507ef2d8fe2","f7482d2f200f48f9ab9038b54aa89d47","52301bd3981a4f87bd6b73e91a73cdd5","94192c28d46a45499e2edd012b584a3c","8d7d9556e9294947ac6a529ba7a8f151","40a2cb1ad9364f7daaab829a8507c5e2","1137876d2ad54acf92ca36cecc8e6733"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline & \\begin{tabular}{l}\nCommon \\\\\nHappens to 21-100 subjects out of every 100\n\\end{tabular} & \\begin{tabular}{l}\nOccasional \\\\\nHappens to 5-20 subjects out of every 100\n\\end{tabular} & \\begin{tabular}{l}\nRare \\\\\nHappens to < 5 subjects out of every 100\n\\end{tabular} \\\\\n\\hline Immediate: Within 1-2 days of receiving drug & & Nausea, vomiting, diarrhea, abdominal pain, rash, pruritus. & Anaphylaxis, allergic reaction, dyspnea, bloating, dyspepsia, taste perversion, QT prolongation, torsade de pointes, headache, dizziness, seizure. \\\\\n\\hline Prompt: Within 2-3 weeks, prior to next course & & Elevated ALT/AST & Stevens-Johnson syndrome and toxic epidermal necrolysis, hypokalemia, hypercholesterolemia, hypertriglyceridemia, leucopenia including neutropenia and agranulocytosis, eosinophilia, thrombocytopenia \\({ }^{ L }\\), hepatitis, cholestasis, fulminant liver failure \\\\\n\\hline Delayed: Any time later during therapy, excluding the above conditions & & & Alopecia with prolonged used \\\\\n\\hline Unknown Frequency and Timing: & & & Pregnancy Category C. There are no adequate and well controlled studies in pregnant women. There have been reports of multiple congenital abnormalities in infants whose mothers were being treated for 3 or more months with high dose ( \\(400-800 mg /\\) day \\()\\) of fluconazole. The relationship between \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|}\n\\hline & \\begin{tabular}{l}\nCommon \\\\\nHappens to 21-100 subjects out of every 100\n\\end{tabular} & \\begin{tabular}{l}\nOccasional \\\\\nHappens to 5-20 subjects out of every 100\n\\end{tabular} & \\begin{tabular}{l}\nRare \\\\\nHappens to < 5 subjects out of every 100\n\\end{tabular} \\\\\n\\hline Immediate: Within 1-2 days of receiving drug & & Nausea, vomiting, diarrhea, abdominal pain, rash, pruritus. & Anaphylaxis, allergic reaction, dyspnea, bloating, dyspepsia, taste perversion, QT prolongation, torsade de pointes, headache, dizziness, seizure. \\\\\n\\hline Prompt: Within 2-3 weeks, prior to next course & & Elevated ALT/AST & Stevens-Johnson syndrome and toxic epidermal necrolysis, hypokalemia, hypercholesterolemia, hypertriglyceridemia, leucopenia including neutropenia and agranulocytosis, eosinophilia, thrombocytopenia \\({ }^{ L }\\), hepatitis, cholestasis, fulminant liver failure \\\\\n\\hline Delayed: Any time later during therapy, excluding the above conditions & & & Alopecia with prolonged used \\\\\n\\hline Unknown Frequency and Timing: & & & Pregnancy Category C. There are no adequate and well controlled studies in pregnant women. There have been reports of multiple congenital abnormalities in infants whose mothers were being treated for 3 or more months with high dose ( \\(400-800 mg /\\) day \\()\\) of fluconazole. The relationship between 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There","confidence":1,"confidence_rate":1},{"cnt":[[458,2394],[1844,2394],[1844,2435],[458,2435]],"region":{"top_left_x":458,"top_left_y":2393,"width":1387,"height":42},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41dbf884e016488f8bbe7ac7eaadec3b","type":"text","conversion_output":false,"parent_id":"1137876d2ad54acf92ca36cecc8e6733","text":"have been reports of multiple congenital abnormalities in infants whose mothers were being treated","text_display":" have been reports of multiple congenital abnormalities in infants whose mothers were being treated","confidence":1,"confidence_rate":1},{"cnt":[[458,2433],[1810,2433],[1810,2474],[458,2474]],"region":{"top_left_x":458,"top_left_y":2432,"width":1352,"height":42},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2dd18c76fef4168a4e3621b927dd688","type":"text","conversion_output":false,"parent_id":"1137876d2ad54acf92ca36cecc8e6733","text":"for 3 or more months with high dose ( \\(400-800 mg /\\) day \\()\\) of fluconazole. The relationship between","text_display":" for 3 or more months with high dose ( \\(400-800 mg /\\) day \\()\\) of fluconazole. 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Fluconazole should be used in pregnancy only if the","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[455,292],[1214,292],[1214,337],[455,337]],"region":{"top_left_x":455,"top_left_y":292,"width":759,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19033e7d890a4b66bdf7880c603328a6","type":"page_info","conversion_output":false,"text":"potential benefit justifies the possible risk to the fetus.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,335],[660,335],[660,376],[245,376]],"region":{"top_left_x":244,"top_left_y":335,"width":416,"height":41},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7f626cdc19e4266b0c5e11460ecf4ea","type":"text","conversion_output":true,"text":"(L) Toxicity may also occur later.","text_display":"\n(L) Toxicity may also occur later.","confidence":0.9990234375,"confidence_rate":0.999974948015144},{"cnt":[[241,415],[685,415],[685,466],[241,466]],"region":{"top_left_x":240,"top_left_y":414,"width":446,"height":53},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d4a2c99c5cb4299bdd0946c67289565","type":"section_header","conversion_output":false,"children_ids":["d638df90217d4f23b90f81db5f17fc53"],"text":"","text_display":""},{"cnt":[[245,417],[681,417],[681,462],[245,462]],"region":{"top_left_x":244,"top_left_y":416,"width":438,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d638df90217d4f23b90f81db5f17fc53","type":"text","conversion_output":true,"parent_id":"2d4a2c99c5cb4299bdd0946c67289565","text":"Formulation and Stability:","text_display":"\n\n\\section*{Formulation and Stability:}","confidence":1,"confidence_rate":1},{"cnt":[[245,464],[1880,464],[1880,509],[245,509]],"region":{"top_left_x":244,"top_left_y":464,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff55e6db874f4092a738a43b54273f53","type":"text","conversion_output":true,"text":"Fluconazole injection is an iso-osmotic, sterile, nonpyrogenic solution of fluconazole in a sodium chloride","text_display":"\n\nFluconazole injection is an iso-osmotic, sterile, nonpyrogenic solution of fluconazole in a sodium chloride","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1882,511],[1882,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1639,"height":50},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86c2845189ac4e3a99bcacc178847cfa","type":"text","conversion_output":true,"text":"or dextrose diluent. Each mL contains 2 mg of fluconazole and 9 mg of sodium chloride or 56 mg of","text_display":" or dextrose diluent. Each mL contains 2 mg of fluconazole and 9 mg of sodium chloride or 56 mg of","confidence":0.99755859375,"confidence_rate":0.9999801270971291},{"cnt":[[245,561],[1880,561],[1880,608],[245,608]],"region":{"top_left_x":244,"top_left_y":560,"width":1636,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41422b808b554828a7b78b583f669ec9","type":"text","conversion_output":true,"text":"dextrose. The pH ranges from 4.0 to 8.0 in the sodium chloride diluent and from 3.5 to 6.5 in the dextrose","text_display":" dextrose. The pH ranges from 4.0 to 8.0 in the sodium chloride diluent and from 3.5 to 6.5 in the dextrose","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1878,606],[1878,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1634,"height":51},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d22e29b2447427ea94377d47ffc758e","type":"text","conversion_output":true,"text":"diluent. Injection volumes of 100 mL and 200 mL are packaged in glass or in polyvinylchloride (PVC)","text_display":" diluent. Injection volumes of 100 mL and 200 mL are packaged in glass or in polyvinylchloride (PVC)","confidence":1,"confidence_rate":1},{"cnt":[[245,655],[1880,655],[1880,707],[245,707]],"region":{"top_left_x":244,"top_left_y":655,"width":1636,"height":52},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c92d210aba34e35bee49ce066eca797","type":"text","conversion_output":true,"text":"bags. Specific storage requirements may vary among manufacturers. In general, fluconazole injection in","text_display":" bags. Specific storage requirements may vary among manufacturers. In general, fluconazole injection in","confidence":1,"confidence_rate":1},{"cnt":[[245,705],[1880,705],[1880,754],[245,754]],"region":{"top_left_x":244,"top_left_y":704,"width":1636,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"760944f1295948d889a7f7252b241560","type":"text","conversion_output":true,"text":"glass bottles or PVC bags should be stored between \\(5-30^{\\circ} C \\left(41-86^{\\circ} F \\right)\\) or between \\(5-25^{\\circ} C \\left(41-77^{\\circ} F \\right)\\),","text_display":" glass bottles or PVC bags should be stored between \\(5-30^{\\circ} C \\left(41-86^{\\circ} F \\right)\\) or between \\(5-25^{\\circ} C \\left(41-77^{\\circ} F \\right)\\),","confidence":0.9970703125,"confidence_rate":0.9999799043975715},{"cnt":[[245,752],[1878,752],[1878,801],[245,801]],"region":{"top_left_x":244,"top_left_y":751,"width":1634,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73fcfaee816f4b49b19e1577e20a7e0e","type":"text","conversion_output":true,"text":"respectively. Brief exposure to \\(40^{\\circ} C \\left(104^{\\circ} F \\right)\\) does not adversely affect the product in the PVC container.","text_display":" respectively. Brief exposure to \\(40^{\\circ} C \\left(104^{\\circ} F \\right)\\) does not adversely affect the product in the PVC container.","confidence":0.99951171875,"confidence_rate":0.9999962717588727},{"cnt":[[245,801],[1880,801],[1880,849],[245,849]],"region":{"top_left_x":244,"top_left_y":801,"width":1636,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0b3e93a832a422ca9c1c48563c1db17","type":"text","conversion_output":true,"text":"Fluconazole solution should be protected from freezing. The overwrap moisture barrier should not be","text_display":" Fluconazole solution should be protected from freezing. The overwrap moisture barrier should not be","confidence":1,"confidence_rate":1},{"cnt":[[245,851],[1880,851],[1880,896],[245,896]],"region":{"top_left_x":244,"top_left_y":850,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2b1c3de08cd44ea9c72b10f0b2cd96f","type":"text","conversion_output":true,"text":"removed from the PVC bags until ready for use. The solution should not be used if it is cloudy or","text_display":" removed from the PVC bags until ready for use. The solution should not be used if it is cloudy or","confidence":1,"confidence_rate":1},{"cnt":[[245,898],[443,898],[443,947],[245,947]],"region":{"top_left_x":244,"top_left_y":898,"width":199,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3793da53b29c4b518c39de0813ecd1f8","type":"text","conversion_output":true,"text":"precipitated.","text_display":" precipitated.","confidence":1,"confidence_rate":1},{"cnt":[[245,990],[1880,990],[1880,1038],[245,1038]],"region":{"top_left_x":244,"top_left_y":990,"width":1636,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"424af473667d4398b740dd73a27e947e","type":"text","conversion_output":true,"text":"Fluconazole is available as \\(50,100,150\\), or 200 mg tablets that may contain lactose. Fluconazole for oral","text_display":"\n\nFluconazole is available as \\(50,100,150\\), or 200 mg tablets that may contain lactose. Fluconazole for oral","confidence":1,"confidence_rate":1},{"cnt":[[245,1040],[1880,1040],[1880,1087],[245,1087]],"region":{"top_left_x":244,"top_left_y":1039,"width":1636,"height":49},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76c52f7fa10a47769be2062754aafeb0","type":"text","conversion_output":true,"text":"suspension contains 350 mg or 1400 mg of fluconazole powder in bottles which may contain sucrose and","text_display":" suspension contains 350 mg or 1400 mg of fluconazole powder in bottles which may contain sucrose and","confidence":0.9985356330871582,"confidence_rate":0.9999872571234004},{"cnt":[[245,1087],[1880,1087],[1880,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1636,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"faef99f0ccb44db79620a2665e48f48a","type":"text","conversion_output":true,"text":"sodium benzoate. The tablets and dry powder of fluconazole for oral suspension should be stored between","text_display":" sodium benzoate. The tablets and dry powder of fluconazole for oral suspension should be stored between","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[552,1134],[552,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1134,"width":309,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7968e990b3244e648337f0f1e19a47c3","type":"text","conversion_output":true,"text":"\\(68-77^{\\circ} F \\left(20-25^{\\circ} C \\right)\\).","text_display":" \\(68-77^{\\circ} F \\left(20-25^{\\circ} C \\right)\\).","confidence":0.9208984375,"confidence_rate":0.997775302020525},{"cnt":[[241,1220],[582,1220],[582,1274],[241,1274]],"region":{"top_left_x":240,"top_left_y":1220,"width":343,"height":55},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d44a92fc5e334685a8ce5c37e465ef90","type":"section_header","conversion_output":false,"children_ids":["f42f2a4353b64312b11f5ee15b30bef8"],"text":"","text_display":""},{"cnt":[[245,1225],[578,1225],[578,1268],[245,1268]],"region":{"top_left_x":244,"top_left_y":1224,"width":334,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f42f2a4353b64312b11f5ee15b30bef8","type":"text","conversion_output":true,"parent_id":"d44a92fc5e334685a8ce5c37e465ef90","text":"CANADIAN SITES:","text_display":"\n\n\\section*{CANADIAN SITES:}","confidence":1,"confidence_rate":1},{"cnt":[[245,1272],[1880,1272],[1880,1319],[245,1319]],"region":{"top_left_x":244,"top_left_y":1271,"width":1636,"height":49},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"714b3377ea00439ab3e436b0cb906e11","type":"text","conversion_output":true,"text":"Fluconazole injection is only available as \\(200 mg / 100 mL\\). Oral fluconazole is available as 50 mg ,","text_display":"\n\nFluconazole injection is only available as \\(200 mg / 100 mL\\). Oral fluconazole is available as 50 mg ,","confidence":1,"confidence_rate":1},{"cnt":[[247,1319],[1880,1319],[1880,1369],[247,1369]],"region":{"top_left_x":247,"top_left_y":1319,"width":1633,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"650c9c48705c41b496ac9ae59a6c2aab","type":"text","conversion_output":true,"text":"100 mg 150 mg and 200 mg tablets. Fluconazole powder for oral suspension is only available as 350 mg","text_display":" 100 mg 150 mg and 200 mg tablets. Fluconazole powder for oral suspension is only available as 350 mg","confidence":0.9990234375,"confidence_rate":0.9999913536688149},{"cnt":[[245,1366],[1197,1366],[1197,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1366,"width":953,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fad8de6a4d449629d68a742930c616a","type":"text","conversion_output":true,"text":"of powder per bottle. Other product specifications are similar.","text_display":" of powder per bottle. Other product specifications are similar.","confidence":0.99951171875,"confidence_rate":0.9999928176655267},{"cnt":[[245,1457],[1695,1457],[1695,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1456,"width":1452,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e6b2ad6bf33432b9aff98a63fd6d758","type":"text","conversion_output":true,"text":"Guidelines for Administration: See Treatment and Dose Modification sections of the protocol.","text_display":"\n\nGuidelines for Administration: See Treatment and Dose Modification sections of the protocol.","confidence":0.9990234375,"confidence_rate":0.9999899274770393},{"cnt":[[241,1543],[415,1543],[415,1601],[241,1601]],"region":{"top_left_x":240,"top_left_y":1542,"width":175,"height":59},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccf4f17fae2749cab71fa3a2b22693ea","type":"section_header","conversion_output":false,"children_ids":["5ed07ff212f14c42ab11affe24fd5f9f"],"text":"","text_display":""},{"cnt":[[245,1547],[410,1547],[410,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1546,"width":167,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ed07ff212f14c42ab11affe24fd5f9f","type":"text","conversion_output":true,"parent_id":"ccf4f17fae2749cab71fa3a2b22693ea","text":"Injection:","text_display":"\n\n\\section*{Injection:}","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1880,1594],[1880,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1594,"width":1636,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e3599d37f49493598acce0f747dad42","type":"text","conversion_output":true,"text":"Fluconazole injection is provided as a \\(2 mg / mL\\) solution in NS or \\(D _{5} W\\) that is ready to infuse without","text_display":"\n\nFluconazole injection is provided as a \\(2 mg / mL\\) solution in NS or \\(D _{5} W\\) that is ready to infuse without","confidence":0.99951171875,"confidence_rate":0.9999962139567942},{"cnt":[[245,1637],[1880,1637],[1880,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1637,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be7d561908484b48aa32351b21b1f62f","type":"text","conversion_output":true,"text":"further dilution. The infusion may be prepared according to standard operating procedures of the institution.","text_display":" further dilution. The infusion may be prepared according to standard operating procedures of the institution.","confidence":1,"confidence_rate":1},{"cnt":[[245,1680],[1880,1680],[1880,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1680,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6a78a35f7324d5cb7c7626004c34e2f","type":"text","conversion_output":true,"text":"For example, the calculated dose volume in NS or \\(D _{5} W\\) may be is transferred to an evacuated PVC infusion","text_display":" For example, the calculated dose volume in NS or \\(D _{5} W\\) may be is transferred to an evacuated PVC infusion","confidence":0.6168398857116699,"confidence_rate":0.9961112438295763},{"cnt":[[245,1723],[1880,1723],[1880,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1723,"width":1636,"height":50},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50d7beead74f4ace9656e233b0748d98","type":"text","conversion_output":true,"text":"bag or to an evacuated glass bottle. Since fluconazole solution contains no preservatives, and as with all","text_display":" bag or to an evacuated glass bottle. Since fluconazole solution contains no preservatives, and as with all","confidence":1,"confidence_rate":1},{"cnt":[[245,1770],[1880,1770],[1880,1815],[245,1815]],"region":{"top_left_x":244,"top_left_y":1770,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a392f623b1241dca4f58762a5830de2","type":"text","conversion_output":true,"text":"parenteral drug products, aseptic technique must be used during the preparation of the dose. Institution","text_display":" parenteral drug products, aseptic technique must be used during the preparation of the dose. 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To reconstitute, add 24 mL","text_display":"\nTo mix the oral suspension tap bottle until all the powder flows freely. To reconstitute, add 24 mL","confidence":1,"confidence_rate":1},{"cnt":[[245,1998],[1880,1998],[1880,2047],[245,2047]],"region":{"top_left_x":244,"top_left_y":1998,"width":1636,"height":50},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86c0a3d95c8e4f93a2f1b443dd4dd810","type":"text","conversion_output":true,"text":"distilled water or Purified Water (USP) to the fluconazole 350 mg or 1400 mg powder in bottle and shake","text_display":" distilled water or Purified Water (USP) to the fluconazole 350 mg or 1400 mg powder in bottle and shake","confidence":1,"confidence_rate":1},{"cnt":[[245,2047],[1880,2047],[1880,2095],[245,2095]],"region":{"top_left_x":244,"top_left_y":2047,"width":1636,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bed51a2a1dc046118f28c0b2b474b49f","type":"text","conversion_output":true,"text":"vigorously to suspend the powder. The concentration of the reconstituted suspension is \\(10 mg / mL\\) for the","text_display":" vigorously to suspend the powder. The concentration of the reconstituted suspension is \\(10 mg / mL\\) for the","confidence":0.9356395897921175,"confidence_rate":0.999426673635977},{"cnt":[[245,2097],[1880,2097],[1880,2144],[245,2144]],"region":{"top_left_x":244,"top_left_y":2096,"width":1636,"height":49},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc008f6db1984d66960e30f7db236086","type":"text","conversion_output":true,"text":"350 mg bottle and \\(40 mg / mL\\) for the 1400 mg bottle with a total volume of 35 mL of suspension per","text_display":" 350 mg bottle and \\(40 mg / mL\\) for the 1400 mg bottle with a total volume of 35 mL of suspension per","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1880,2144],[1880,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2144,"width":1636,"height":50},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0af20f78dfe4989a2a38500888069ec","type":"text","conversion_output":true,"text":"bottle. The reconstituted suspension should be stored between \\(86^{\\circ} F \\left(30^{\\circ} C \\right)\\) and \\(41^{\\circ} F \\left(5^{\\circ} C \\right)\\). Protect from","text_display":" bottle. The reconstituted suspension should be stored between \\(86^{\\circ} F \\left(30^{\\circ} C \\right)\\) and \\(41^{\\circ} F \\left(5^{\\circ} C \\right)\\). Protect from","confidence":0.97802734375,"confidence_rate":0.9998538419288845},{"cnt":[[245,2194],[1880,2194],[1880,2241],[245,2241]],"region":{"top_left_x":244,"top_left_y":2193,"width":1636,"height":48},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d531f32255f420d85f5da2109d04c5b","type":"text","conversion_output":true,"text":"freezing. Discard unused portion 2 weeks after reconstitution. Patients should be instructed to shake the","text_display":" freezing. Discard unused portion 2 weeks after reconstitution. Patients should be instructed to shake the","confidence":1,"confidence_rate":1},{"cnt":[[245,2241],[1880,2241],[1880,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2240,"width":1636,"height":49},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3dbb39aaaa84e0d975f8f69c15a6947","type":"text","conversion_output":true,"text":"oral suspension well before using. Oral fluconazole should be administered with or without food at","text_display":" oral suspension well before using. 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See package insert for further information.","text_display":"\n\nSupplier: Commercially available from various manufacturers. See package insert for further information.","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[612,2582],[612,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":369,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d611e79a6c94bc5a47094db9c0d9529","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2585],[1876,2585],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2584,"width":128,"height":44},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"634848f6a08a4a26b5fcd273cf0f142c","type":"page_info","conversion_output":false,"text":"Page 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CASPOFUNGIN (caspofungin acetate, Cancidas \\({ }^{\\circledR}\\) )","text_display":"\n6.2 CASPOFUNGIN (caspofungin acetate, Cancidas \\({ }^{\\circledR}\\) )","confidence":0.6260650726035237,"confidence_rate":0.9928212609254699},{"cnt":[[243,387],[698,387],[698,436],[243,436]],"region":{"top_left_x":242,"top_left_y":386,"width":457,"height":51},"line":8,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e376341af1574c148f4c3fb6eb8b2a0a","type":"section_header","conversion_output":false,"parent_id":"d6247be9bd574512953ffdf04322a806","children_ids":["df213c3343bb462fb05a20d20a891e20"],"text":"","text_display":""},{"cnt":[[245,389],[694,389],[694,432],[245,432]],"region":{"top_left_x":244,"top_left_y":388,"width":450,"height":44},"line":9,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df213c3343bb462fb05a20d20a891e20","type":"text","conversion_output":true,"parent_id":"e376341af1574c148f4c3fb6eb8b2a0a","text":"Source and Pharmacology:","text_display":"\n\n\\section*{Source and Pharmacology:}","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1880,430],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":429,"width":1636,"height":46},"line":10,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8a41616f4d848958aac169c943f3071","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"Caspofungin acetate, a semisynthetic lipopeptide synthesized from a fermentation product of Glarea","text_display":"\n\nCaspofungin acetate, a semisynthetic lipopeptide synthesized from a fermentation product of Glarea","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1880,473],[1880,520],[245,520]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":48},"line":11,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"201d8e1bcc4449a5af78945cf6c6424c","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"lozoyensis, is an echinocandin antifungal agent. It inhibits the synthesis of beta (1, 3)-D-glucan, an","text_display":" lozoyensis, is an echinocandin antifungal agent. It inhibits the synthesis of beta (1, 3)-D-glucan, an","confidence":0.9936609268188477,"confidence_rate":0.9999405695191381},{"cnt":[[245,518],[1880,518],[1880,563],[245,563]],"region":{"top_left_x":244,"top_left_y":517,"width":1636,"height":46},"line":12,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f9af82083604c8587d85fb89fa7328e","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"essential component of filamentous fungal cell wall that is not present in mammalian cells. Caspofungin","text_display":" essential component of filamentous fungal cell wall that is not present in mammalian cells. Caspofungin","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":47},"line":13,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c9150e0595b48a18f87f2d7b61d72f1","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"has been shown to be active both in vitro and in clinical infections against most strains of the following","text_display":" has been shown to be active both in vitro and in clinical infections against most strains of the following","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,606],[1876,606],[1876,651],[245,651]],"region":{"top_left_x":244,"top_left_y":605,"width":1632,"height":46},"line":14,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb986b19bb1a45e8b802da411025f33c","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"organisms: Aspergillus (A) fumigatus, A flavus, A terreus, Candida (C) albicans, C glabrata,","text_display":" organisms: Aspergillus (A) fumigatus, A flavus, A terreus, Candida (C) albicans, C glabrata,","confidence":0.6673667504098368,"confidence_rate":0.995839446878953},{"cnt":[[245,649],[1880,649],[1880,696],[245,696]],"region":{"top_left_x":244,"top_left_y":648,"width":1636,"height":49},"line":15,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c7296389c7d485baaec2b03bc59a1a3","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"C guilliermondii, C krusei, C parapsilosis, C tropicalis. Following an intravenous infusion, the plasma","text_display":" C guilliermondii, C krusei, C parapsilosis, C tropicalis. Following an intravenous infusion, the plasma","confidence":0.9975595474243164,"confidence_rate":0.9999773758546899},{"cnt":[[245,694],[1880,694],[1880,741],[245,741]],"region":{"top_left_x":244,"top_left_y":693,"width":1636,"height":49},"line":16,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13e46b6def0647809798ede2649709be","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"concentration of caspofungin declines in a polyphasic manner. A short alpha-phase that occurs","text_display":" concentration of caspofungin declines in a polyphasic manner. A short alpha-phase that occurs","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1880,735],[1880,784],[245,784]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":51},"line":17,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d1018f8eb684539beff3680d483eabd","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"immediately post-infusion is followed by a beta-phase (half-life of 9 to 11 hours) and an additional,","text_display":" immediately post-infusion is followed by a beta-phase (half-life of 9 to 11 hours) and an additional,","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1878,782],[1878,827],[245,827]],"region":{"top_left_x":244,"top_left_y":782,"width":1634,"height":46},"line":18,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1673a04681fe424fa72b283edcf6b09f","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"longer half-life phase, gamma-phase (half-life of \\(40-50\\) hours). Caspofungin is extensively (about \\(97 \\%\\) )","text_display":" longer half-life phase, gamma-phase (half-life of \\(40-50\\) hours). 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Caspofungin is slowly metabolized in the liver via hydrolysis and \\(N\\)-acetylation.","text_display":" biotransformation). Caspofungin is slowly metabolized in the liver via hydrolysis and \\(N\\)-acetylation.","confidence":1,"confidence_rate":1},{"cnt":[[245,913],[1880,913],[1880,958],[245,958]],"region":{"top_left_x":244,"top_left_y":913,"width":1636,"height":46},"line":21,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41dc619a1c1e47229fd27a785315f7d0","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"Following a single intravenous dose, \\(35 \\%\\) of the parent drug and metabolites was excreted in feces and","text_display":" Following a single intravenous dose, \\(35 \\%\\) of the parent drug and metabolites was excreted in feces and","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[245,956],[1878,956],[1878,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":956,"width":1634,"height":48},"line":22,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"568a3cef91de43b8a3dd2dc3710988a6","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"\\(41 \\%\\) was excreted in the urine. After multiple doses of caspofungin \\(50 mg /\\) day were given intravenously","text_display":" \\(41 \\%\\) was excreted in the urine. After multiple doses of caspofungin \\(50 mg /\\) day were given intravenously","confidence":0.9795436859130859,"confidence_rate":0.9998138151509961},{"cnt":[[245,1001],[1880,1001],[1880,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":1001,"width":1636,"height":46},"line":23,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c607e5902f5b41c28cdb9de936f81207","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"to adults, the total body clearance was \\(10.6 \\pm 3.8 mL / min\\). When a dose of \\(50 mg / m ^{2} /\\) day was given","text_display":" to adults, the total body clearance was \\(10.6 \\pm 3.8 mL / min\\). When a dose of \\(50 mg / m ^{2} /\\) day was given","confidence":0.99951171875,"confidence_rate":0.9999960612940623},{"cnt":[[245,1044],[1880,1044],[1880,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1044,"width":1636,"height":46},"line":24,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26f0f02e7daf4d8c9e9e5776249ddf11","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"intravenously to children and adolescents, the total body clearance was \\(12.6 \\pm 5.5 mL / min\\) in adolescents","text_display":" intravenously to children and adolescents, the total body clearance was \\(12.6 \\pm 5.5 mL / min\\) in adolescents","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,1087],[1880,1087],[1880,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1636,"height":50},"line":25,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"777546e00d434ae9b411e72414e0f178","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"(12 to 17 years of age), \\(6.4 \\pm 2.6 mL / min\\) in children 2 to 11 years and \\(3.2 \\pm 0.4 mL / min\\) in children 3 to","text_display":" (12 to 17 years of age), \\(6.4 \\pm 2.6 mL / min\\) in children 2 to 11 years and \\(3.2 \\pm 0.4 mL / min\\) in children 3 to","confidence":0.9970724578015506,"confidence_rate":0.999978120867471},{"cnt":[[245,1134],[423,1134],[423,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1134,"width":180,"height":42},"line":26,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"699fd6303b0f4229b4045635a1c2984d","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"23 months.","text_display":" 23 months.","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1880,1220],[1880,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1220,"width":1636,"height":46},"line":27,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2189293fffb34030ba3e1823fb4d04a3","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"Caspofungin is not a substrate for P -glycoprotein and is a poor substrate for, and does not inhibit or","text_display":"\n\nCaspofungin is not a substrate for P -glycoprotein and is a poor substrate for, and does not inhibit or","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[245,1263],[1880,1263],[1880,1311],[245,1311]],"region":{"top_left_x":244,"top_left_y":1263,"width":1636,"height":48},"line":28,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb72ceefd04b46aab0d935b83583ebbc","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"induce, cytochrome P-450 isoenzymes in vitro. However, coadministration of caspofungin with certain","text_display":" induce, cytochrome P-450 isoenzymes in vitro. However, coadministration of caspofungin with certain","confidence":0.9970703125,"confidence_rate":0.9999717889802962},{"cnt":[[245,1308],[1880,1308],[1880,1354],[245,1354]],"region":{"top_left_x":244,"top_left_y":1308,"width":1636,"height":46},"line":29,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69be56f7d4c645fc9933acb7ba939e8b","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"inducers of drug clearance and/or mixed inducer/inhibitors (e.g., efavirenz, nevirapine, phenytoin,","text_display":" inducers of drug clearance and/or mixed inducer/inhibitors (e.g., efavirenz, nevirapine, phenytoin,","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1880,1354],[1880,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1636,"height":46},"line":30,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4513d6d80c649a8becbf68b1446a041","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"rifampin, dexamethasone, and carbamazepine) may result in clinically important reductions in plasma","text_display":" rifampin, dexamethasone, and carbamazepine) may result in clinically important reductions in plasma","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1880,1396],[1880,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1396,"width":1636,"height":46},"line":31,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db6e577b3eb5433b96a869ec599068b0","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"caspofungin concentrations. Cyclosporine increases caspofungin area under the curve (AUC) which","text_display":" caspofungin concentrations. Cyclosporine increases caspofungin area under the curve (AUC) which","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1880,1439],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":46},"line":32,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ba03fa8fa784de68e56af3fc023fec4","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"results in a transient elevation of alanine transaminase (ALT) and aspartate transaminase (AST) and","text_display":" results in a transient elevation of alanine transaminase (ALT) and aspartate transaminase (AST) and","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1244,1482],[1244,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1482,"width":1000,"height":50},"line":33,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e37e4b0f80d448887baa5d90f55ac2f","type":"text","conversion_output":true,"parent_id":"d6247be9bd574512953ffdf04322a806","text":"coadministration with tacrolimus may decrease tacrolimus AUC.","text_display":" coadministration with tacrolimus may decrease tacrolimus 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protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.9464174825881173,"confidence_rate":0.999311843216534},{"cnt":[[1693,125],[1880,125],[1880,165],[1693,165]],"region":{"top_left_x":1692,"top_left_y":124,"width":188,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84b5ef2049eb42c5be320e154e81a1dd","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[363,155],[363,187],[262,187]],"region":{"top_left_x":262,"top_left_y":154,"width":102,"height":33},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57f8852d030d42b099ec4fa23ed0de71","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[397,296],[397,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":154,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8c43a05cadf4befb31bd24d5998cee0","type":"figure_label","conversion_output":false,"text":"Toxicity:","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,335],[1882,335],[1882,1674],[245,1674]],"region":{"top_left_x":244,"top_left_y":335,"width":1639,"height":1339},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e960508787014fc2a680a39b0e13ecb9","type":"table","conversion_output":true,"children_ids":["e6743d8c745444b5908027d2022fcc14","23f980a3f9cb4700ba9738809cc8be79","9bd44f5080864c5d871ac546ca73e7d3","df2b774a679e44b69926410605f31cb4","b26d0e68602a47f3957189c51acb301d","0b7c210f15134fa4bf5067f1082347f0","5b502c741f2849a4b34593372b780f71","9a151fd464384ce09474c484ca267f64","3aaa06df7186419f96386399c35565a3","7c6c5560a15c40488b754b75920ed311","8de36575babd490088405aed8df03ce6","4b835fb2a90944f6b7d45e4dc00319c8","cff424f5866049129d95da5e82918b5f","d9d0fc8ef2484612bb5b9fc521dc5630","e395cb53f4894ef49ec2809920546fd8","0d9345238d1943d493872ea78ebeae9f","c19d45bf3d164e4b8e502890de2f1224","713933b83aa249f1954d2898db0bdad2","33ee3c3e094540f0b31b0cd50dd18e98","9f6f2f8b46364c47b2466b2cbccddcf0","94d4ac6834e74c0da737756a039b3508"],"selected_labels":["a8c43a05cadf4befb31bd24d5998cee0"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline & \\begin{tabular}{l}\nCommon \\\\\nHappens to 21-100 subjects out of every 100\n\\end{tabular} & \\begin{tabular}{l}\nOccasional \\\\\nHappens to 5-20 subjects out of every 100\n\\end{tabular} & \\begin{tabular}{l}\nRare \\\\\nHappens to < 5 subjects out of every 100\n\\end{tabular} \\\\\n\\hline Immediate: Within 1-2 days of receiving drug & Pyrexia, chills, diarrhea, rash, infusion reaction (systemic) & Peripheral edema, phlebitis, nausea, vomiting, abdominal pain, cough, erythema, headache, hypotension & Anaphylaxis, respiratory failure, infusion site pain/pruritus/swelling, urticaria, arrhythmia, atrial fibrillation, bradycardia, cardiac arrest, myocardial infarction, tachycardia, abdominal distension, upper abdominal pain, constipation, dyspepsia, asthenia, fatigue, anorexia, dizziness, somnolence, tremor, flushing, hypertension \\\\\n\\hline Prompt: Within 2-3 weeks, prior to next course & Hypokalemia & Increase liver function tests (ALT/AST/Alkaline phosphatase), increase bilirubin, pneumonia & Anemia, coagulopathy, febrile neutropenia, neutropenia, thrombocytopenia, mucosal inflammation, petechiae, hepatic failure, hepatomegaly, hepatotoxicity, hepatic necrosis, jaundice, bacteremia, sepsis, urinary tract infection hypomagnesemia, hypercalcemia, hyperglycemia, arthralgia, back pain, pain in extremity, convulsion, anxiety, confusional state, depression, insomnia, hematuria, renal failure, dyspnea, epistaxis, hypoxia, tachypnea, pancreatitis, erythema multiforme, Stevens-Johnson, skin exfoliation \\\\\n\\hline Unknown Frequency and Timing: & \\multicolumn{3}{|c|}{\\begin{tabular}{l}\nU.S. Food and Drug Administration's Pregnancy Category: Category C. It is not known if caspofungin crosses the placenta in humans. There are no adequate and well-controlled studies with the use of caspofungin in pregnant women. \\\\\nIn animal studies, caspofungin acetate has been shown to be embryotoxic. Abnormalities in rats, treated with caspofungin doses comparable to the human dose, included incomplete ossification of the skull and torso and increased incidence of cervical rib. In rabbits, incomplete ossifications of the talus/calcaneus were noted. In rats and rabbits caspofungin crossed the placenta and was evident in fetal plasma.\n\\end{tabular}} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Toxicity:}\n\\begin{tabular}{|l|l|l|l|}\n\\hline & \\begin{tabular}{l}\nCommon \\\\\nHappens to 21-100 subjects out of every 100\n\\end{tabular} & \\begin{tabular}{l}\nOccasional \\\\\nHappens to 5-20 subjects out of every 100\n\\end{tabular} & \\begin{tabular}{l}\nRare \\\\\nHappens to < 5 subjects out of every 100\n\\end{tabular} \\\\\n\\hline Immediate: Within 1-2 days of receiving drug & Pyrexia, chills, diarrhea, rash, infusion reaction (systemic) & Peripheral edema, phlebitis, nausea, vomiting, abdominal pain, cough, erythema, headache, hypotension & Anaphylaxis, respiratory failure, infusion site pain/pruritus/swelling, urticaria, arrhythmia, atrial fibrillation, bradycardia, cardiac arrest, myocardial infarction, tachycardia, abdominal distension, upper abdominal pain, constipation, dyspepsia, asthenia, fatigue, anorexia, dizziness, somnolence, tremor, flushing, hypertension \\\\\n\\hline Prompt: Within 2-3 weeks, prior to next course & Hypokalemia & Increase liver function tests (ALT/AST/Alkaline phosphatase), increase bilirubin, pneumonia & Anemia, coagulopathy, febrile neutropenia, neutropenia, thrombocytopenia, mucosal inflammation, petechiae, hepatic failure, hepatomegaly, hepatotoxicity, hepatic necrosis, jaundice, bacteremia, sepsis, urinary tract infection hypomagnesemia, hypercalcemia, hyperglycemia, arthralgia, back pain, pain in extremity, convulsion, anxiety, confusional state, depression, insomnia, hematuria, renal failure, dyspnea, epistaxis, hypoxia, tachypnea, pancreatitis, erythema multiforme, Stevens-Johnson, skin exfoliation \\\\\n\\hline Unknown Frequency and Timing: & \\multicolumn{3}{|c|}{\\begin{tabular}{l}\nU.S. Food and Drug Administration's Pregnancy Category: Category C. It is not known if caspofungin crosses the placenta in humans. There are no adequate and well-controlled studies with the use of caspofungin in pregnant women. \\\\\nIn animal studies, caspofungin acetate has been shown to be embryotoxic. Abnormalities in rats, treated with caspofungin doses comparable to the human dose, included incomplete ossification of the skull and torso and increased incidence of cervical rib. In rabbits, incomplete ossifications of the talus/calcaneus were noted. In rats and rabbits caspofungin crossed the placenta and was evident in fetal plasma.\n\\end{tabular}} \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.998046875,"confidence_rate":0.9999977331612677},{"cnt":[[248,335],[474,335],[474,1673],[248,1673]],"region":{"top_left_x":248,"top_left_y":335,"width":226,"height":1339},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6743d8c745444b5908027d2022fcc14","type":"table_column","conversion_output":false,"parent_id":"e960508787014fc2a680a39b0e13ecb9","text":"","text_display":""},{"cnt":[[487,335],[846,335],[846,1673],[487,1673]],"region":{"top_left_x":486,"top_left_y":335,"width":361,"height":1339},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23f980a3f9cb4700ba9738809cc8be79","type":"table_column","conversion_output":false,"parent_id":"e960508787014fc2a680a39b0e13ecb9","text":"","text_display":""},{"cnt":[[844,335],[1244,335],[1244,1673],[844,1673]],"region":{"top_left_x":843,"top_left_y":335,"width":402,"height":1339},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bd44f5080864c5d871ac546ca73e7d3","type":"table_column","conversion_output":false,"parent_id":"e960508787014fc2a680a39b0e13ecb9","text":"","text_display":""},{"cnt":[[1242,335],[1881,335],[1881,1673],[1242,1673]],"region":{"top_left_x":1242,"top_left_y":335,"width":640,"height":1339},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df2b774a679e44b69926410605f31cb4","type":"table_column","conversion_output":false,"parent_id":"e960508787014fc2a680a39b0e13ecb9","text":"","text_display":""},{"cnt":[[244,339],[1883,339],[1883,500],[244,500]],"region":{"top_left_x":244,"top_left_y":339,"width":1640,"height":161},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b26d0e68602a47f3957189c51acb301d","type":"table_row","conversion_output":false,"parent_id":"e960508787014fc2a680a39b0e13ecb9","text":"","text_display":""},{"cnt":[[244,500],[1883,500],[1883,827],[244,827]],"region":{"top_left_x":244,"top_left_y":499,"width":1640,"height":328},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b7c210f15134fa4bf5067f1082347f0","type":"table_row","conversion_output":false,"parent_id":"e960508787014fc2a680a39b0e13ecb9","text":"","text_display":""},{"cnt":[[243,824],[1883,822],[1884,1346],[244,1348]],"region":{"top_left_x":243,"top_left_y":822,"width":1641,"height":527},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b502c741f2849a4b34593372b780f71","type":"table_row","conversion_output":false,"parent_id":"e960508787014fc2a680a39b0e13ecb9","text":"","text_display":""},{"cnt":[[244,1344],[1883,1344],[1883,1671],[244,1671]],"region":{"top_left_x":244,"top_left_y":1344,"width":1640,"height":328},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a151fd464384ce09474c484ca267f64","type":"table_row","conversion_output":false,"parent_id":"e960508787014fc2a680a39b0e13ecb9","text":"","text_display":""},{"cnt":[[513,344],[814,344],[814,497],[513,497]],"region":{"top_left_x":512,"top_left_y":343,"width":302,"height":155},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3aaa06df7186419f96386399c35565a3","type":"complex_cell","conversion_output":false,"parent_id":"e960508787014fc2a680a39b0e13ecb9","children_ids":["35b6d5e8be9a4f38a4632a43bc4dd4f9","7f7045b77c30480c8f6360d3b43a831d","6a8adb6943a74b89893bc266f878a288","f75bebc6c40e49c3be4cf0ae0ce38e8b"],"text":"\\begin{tabular}{l}\nCommon 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Mix gently until a clear solution is obtained.","text_display":"\nThe white to off-white cake will dissolve completely. 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The final concentration should not exceed \\(0.5 mg / mL\\). The","text_display":" Injection or Lactated Ringers Injection. The final concentration should not exceed \\(0.5 mg / mL\\). The","confidence":0.9941432476043701,"confidence_rate":0.9999470827476383},{"cnt":[[245,1227],[1882,1227],[1882,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1226,"width":1639,"height":49},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4df84cbcb374f308ffddc96c716c944","type":"text","conversion_output":true,"text":"stability of the diluted solution for administration is 24 hours if stored at \\(\\leq 25^{\\circ} C \\left(\\leq 77^{\\circ} F \\right)\\) or 48 hours if","text_display":" stability of the diluted solution for administration is 24 hours if stored at \\(\\leq 25^{\\circ} C \\left(\\leq 77^{\\circ} F \\right)\\) or 48 hours if","confidence":0.6787109375,"confidence_rate":0.9972156822714087},{"cnt":[[245,1272],[1880,1272],[1880,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1271,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c39f7ef2939046e4a0e5d279294744db","type":"text","conversion_output":true,"text":"stored refrigerated at 2 to \\(8^{\\circ} C\\) ( 36 to \\(46^{\\circ} F\\) ). Since the infusion solution contains no preservatives and as","text_display":" stored refrigerated at 2 to \\(8^{\\circ} C\\) ( 36 to \\(46^{\\circ} F\\) ). 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Institution guidelines should be followed to determine the expiration time of the infusion solution.","text_display":" bag. Institution guidelines should be followed to determine the expiration time of the infusion solution.","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1682,1401],[1682,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1400,"width":1439,"height":51},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0939fecb9c05434490f5f654e4966f77","type":"text","conversion_output":true,"text":"The expiration time should not exceed 24 hours at \\(\\leq 25^{\\circ} C \\left(\\leq 77^{\\circ} F \\right)\\) and 48 hours refrigerated.","text_display":" The expiration time should not exceed 24 hours at \\(\\leq 25^{\\circ} C \\left(\\leq 77^{\\circ} F \\right)\\) and 48 hours refrigerated.","confidence":0.708984375,"confidence_rate":0.997207793360473},{"cnt":[[245,1491],[1880,1491],[1880,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1491,"width":1636,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec6a8790616140e1890e7bd7d2b344af","type":"text","conversion_output":true,"text":"Caspofungin is administered by slow intravenous infusion over no less than 1 hour. Do not mix or co-","text_display":"\n\nCaspofungin is administered by slow intravenous infusion over no less than 1 hour. Do not mix or co","confidence":1,"confidence_rate":1},{"cnt":[[245,1534],[1882,1534],[1882,1583],[245,1583]],"region":{"top_left_x":244,"top_left_y":1533,"width":1639,"height":51},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffe6f1dab078495cafaaac4a9e50fed8","type":"text","conversion_output":true,"text":"infuse caspofungin with other medications, as there are no data available on the compatibility of","text_display":"infuse caspofungin with other medications, as there are no data available on the compatibility of","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1880,1577],[1880,1626],[245,1626]],"region":{"top_left_x":244,"top_left_y":1576,"width":1636,"height":51},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"244dbfd778a74681bc2971521c884357","type":"text","conversion_output":true,"text":"caspofungin with other intravenous medications. DO NOT USE DILUENTS CONTAINING","text_display":" caspofungin with other intravenous medications. DO NOT USE DILUENTS CONTAINING","confidence":1,"confidence_rate":1},{"cnt":[[245,1622],[1880,1622],[1880,1669],[245,1669]],"region":{"top_left_x":244,"top_left_y":1622,"width":1636,"height":48},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e48b002986144884be7fcf6f5a520774","type":"text","conversion_output":true,"text":"DEXTROSE since caspofungin is not stable in diluents containing dextrose. The infusion line should be","text_display":" DEXTROSE since caspofungin is not stable in diluents containing dextrose. The infusion line should be","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[1360,1663],[1360,1712],[245,1712]],"region":{"top_left_x":244,"top_left_y":1662,"width":1116,"height":51},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"803c04eb7c704d1b88f786348e266dd7","type":"text","conversion_output":true,"text":"flushed with \\(0.9 \\%\\) sodium chloride before and after drug administration.","text_display":" flushed with \\(0.9 \\%\\) sodium chloride before and after drug administration.","confidence":0.943359375,"confidence_rate":0.9992621967236104},{"cnt":[[245,1753],[1880,1753],[1880,1803],[245,1803]],"region":{"top_left_x":244,"top_left_y":1753,"width":1636,"height":50},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce36ecf7b8474fe4b49ab7d7a037c6eb","type":"text","conversion_output":true,"text":"Supplier: Caspofungin will be supplied by the manufacturer Merck \\& Company, Inc., USA. The","text_display":"\n\nSupplier: Caspofungin will be supplied by the manufacturer Merck \\& Company, Inc., USA. 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neutropenia following chemotherapy for AML is associated with a lower incidence of proven or probable IFI","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,1023],[1880,1023],[1880,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1022,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7da6ec4c773f44ae85a89d9207b25385","type":"text","conversion_output":true,"text":"compared with fluconazole. Eligible AML patients at ages 3 months to 30 years will be randomized to","text_display":" compared with fluconazole. Eligible AML patients at ages 3 months to 30 years will be randomized to","confidence":1,"confidence_rate":1},{"cnt":[[245,1066],[1880,1066],[1880,1113],[245,1113]],"region":{"top_left_x":244,"top_left_y":1065,"width":1636,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49851842f3624d7994c50b5adb49ad81","type":"text","conversion_output":true,"text":"receive daily prophylaxis with either caspofungin or fluconazole. Randomization will be stratified into","text_display":" receive daily prophylaxis with either caspofungin or fluconazole. Randomization will be stratified into","confidence":1,"confidence_rate":1},{"cnt":[[245,1109],[1003,1109],[1003,1158],[245,1158]],"region":{"top_left_x":244,"top_left_y":1108,"width":760,"height":51},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6126b4a9e5ad4103b3e1444254b989f1","type":"text","conversion_output":true,"text":"2 groups: 1) de novo AML vs. 2) all other patients.","text_display":" 2 groups: 1) de novo AML vs. 2) all other patients.","confidence":0.99951171875,"confidence_rate":0.9999911200303706},{"cnt":[[241,1192],[1164,1192],[1164,1250],[241,1250]],"region":{"top_left_x":240,"top_left_y":1192,"width":925,"height":59},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f39a49b956db4cfda02afd0096d01a0b","type":"section_header","conversion_output":false,"children_ids":["e90868fd77ff45d8a2c9329d3d2a144e"],"text":"","text_display":""},{"cnt":[[245,1199],[1160,1199],[1160,1244],[245,1244]],"region":{"top_left_x":244,"top_left_y":1198,"width":917,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e90868fd77ff45d8a2c9329d3d2a144e","type":"text","conversion_output":true,"parent_id":"f39a49b956db4cfda02afd0096d01a0b","text":"9.2 Patient Accrual and Expected Duration of Trial","text_display":"\n\n\\subsection*{9.2 Patient Accrual and Expected Duration of Trial}","confidence":1,"confidence_rate":1},{"cnt":[[245,1242],[1880,1242],[1880,1287],[245,1287]],"region":{"top_left_x":244,"top_left_y":1241,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68c7e69ea8f447d29bcc6916643e50d1","type":"text","conversion_output":true,"text":"Eligible subjects will have de novo, relapsed, or secondary AML, or any diagnosis being treated with","text_display":"\n\nEligible subjects will have de novo, relapsed, or secondary AML, or any diagnosis being treated with","confidence":1,"confidence_rate":1},{"cnt":[[245,1285],[1880,1285],[1880,1330],[245,1330]],"region":{"top_left_x":244,"top_left_y":1284,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2b73703acdd403a9cfa526c42cf3eec","type":"text","conversion_output":true,"text":"institutional standard AML therapy (for example myelodysplastic syndrome, bone marrow blasts > 5\\% or","text_display":" institutional standard AML therapy (for example myelodysplastic syndrome, bone marrow blasts > 5\\% or","confidence":0.63671875,"confidence_rate":0.995709921707559},{"cnt":[[245,1328],[1880,1328],[1880,1377],[245,1377]],"region":{"top_left_x":244,"top_left_y":1327,"width":1636,"height":51},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45adb78e1a61468a8ee11be1026057a0","type":"text","conversion_output":true,"text":"biphenotypia). This protocol does not require concurrent enrollment on a COG therapeutic protocol.","text_display":" biphenotypia). 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The","confidence":1,"confidence_rate":1},{"cnt":[[245,1461],[1880,1461],[1880,1508],[245,1508]],"region":{"top_left_x":244,"top_left_y":1460,"width":1636,"height":49},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ff5e8a38d114821923f9af5f22faae2","type":"text","conversion_output":true,"text":"de novo AML therapeutic protocol, AAML0531, accrued over 300 patients per year and the subsequent","text_display":" de novo AML therapeutic protocol, AAML0531, accrued over 300 patients per year and the subsequent","confidence":1,"confidence_rate":1},{"cnt":[[245,1504],[1880,1504],[1880,1553],[245,1553]],"region":{"top_left_x":244,"top_left_y":1503,"width":1636,"height":51},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d4161657c7545219a9d525fa0f44371","type":"text","conversion_output":true,"text":"de novo AML protocol, AAML1031, is projected to accrue about 290 patients per year. 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The potential","confidence":1,"confidence_rate":1},{"cnt":[[245,1549],[1880,1549],[1880,1596],[245,1596]],"region":{"top_left_x":244,"top_left_y":1549,"width":1636,"height":48},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a1444a1c2654ceaa1f7bd0bac4b802e","type":"text","conversion_output":true,"text":"patient pool for ACCL0933 will be larger than AAML1031, and therefore, the accrual rate for this study","text_display":" patient pool for ACCL0933 will be larger than AAML1031, and therefore, the accrual rate for this study","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1880,1594],[1880,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1594,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c91b40ede0334a70bec44bb3b284b744","type":"text","conversion_output":true,"text":"is expected to be about 150 patients per year. 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Central Committee Review","text_display":"\n\n\\subsection*{9.3.2 Central Committee Review}","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"413cd96c032e473ebdb9e615123e56e0","type":"text","conversion_output":true,"text":"In order to ensure consistent and accurate application of the EORTC/MSG guidelines across all study","text_display":"\n\nIn order to ensure consistent and accurate application of the EORTC/MSG guidelines across all study","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1880,382],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1636,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"326a806f4c674f3e898ebda41a3e1d46","type":"text","conversion_output":true,"text":"patients, a Central Review Committee including Pediatric Oncologists and Pediatric Infectious Disease","text_display":" patients, a Central Review Committee including Pediatric Oncologists and Pediatric Infectious Disease","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c57bc1256eeb4e7f988abb07fbc90e82","type":"text","conversion_output":true,"text":"Specialists will be assembled. Through consensus meetings, committee members will review all data","text_display":" Specialists will be assembled. Through consensus meetings, committee members will review all data","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1880,471],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1636,"height":48},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80dcd55bab484f17a2eeb9686990287b","type":"text","conversion_output":true,"text":"pertinent to the EORTC/MSG guidelines and determine whether a patient sustained a possible, probable","text_display":" pertinent to the EORTC/MSG guidelines and determine whether a patient sustained a possible, probable","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1878,516],[1878,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1634,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33baca1aa2414e1d97d39ae9e9b91bea","type":"text","conversion_output":true,"text":"or proven IFI or IA infection during the study period. The following data for each study patient will be","text_display":" or proven IFI or IA infection during the study period. The following data for each study patient will be","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1878,559],[1878,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":1634,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c25eb7bd298b4c97bbfc66f351579057","type":"text","conversion_output":true,"text":"collected and available at the time of the review: pathology reports, all CT scan and MRI reports, fungal","text_display":" collected and available at the time of the review: pathology reports, all CT scan and MRI reports, fungal","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1880,602],[1880,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1636,"height":48},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cae93ea84c34e84b70c3e7d844025ef","type":"text","conversion_output":true,"text":"Gram stain and microbiology culture results, non-culture mycology testing results (i.e., Histoplasma urine","text_display":" Gram stain and microbiology culture results, non-culture mycology testing results (i.e., Histoplasma urine","confidence":1,"confidence_rate":1},{"cnt":[[245,647],[1880,647],[1880,694],[245,694]],"region":{"top_left_x":244,"top_left_y":646,"width":1636,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb251e9ff79e406eadf986dfa68d8d74","type":"text","conversion_output":true,"text":"antigens, cryptococcal CSF and serum antigens), ophthalmology exams, bronchoscopy reports, and","text_display":" antigens, cryptococcal CSF and serum antigens), ophthalmology exams, bronchoscopy reports, and","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[883,692],[883,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":640,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9780fb0a334947a2aae11b34ac3cc95a","type":"text","conversion_output":true,"text":"dosing and duration of steroid exposures.","text_display":" dosing and duration of steroid exposures.","confidence":1,"confidence_rate":1},{"cnt":[[245,765],[1880,765],[1880,814],[245,814]],"region":{"top_left_x":244,"top_left_y":764,"width":1636,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15c04bbed13d4a7ea4472431cbb1dd76","type":"text","conversion_output":true,"text":"All reviewers will be blinded to the patient's antifungal exposures in order to limit any bias in","text_display":"\n\nAll reviewers will be blinded to the patient's antifungal exposures in order to limit any bias in","confidence":1,"confidence_rate":1},{"cnt":[[245,810],[1021,810],[1021,857],[245,857]],"region":{"top_left_x":244,"top_left_y":809,"width":777,"height":49},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"edaf13db9b774b5b8eade6713827291b","type":"text","conversion_output":true,"text":"determining the primary and secondary endpoints.","text_display":" determining the primary and secondary endpoints.","confidence":1,"confidence_rate":1},{"cnt":[[236,889],[943,889],[943,952],[236,952]],"region":{"top_left_x":236,"top_left_y":889,"width":708,"height":63},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e5b8400e83849c38a01266106110b3e","type":"section_header","conversion_output":false,"children_ids":["24e9bc7742e74311a8e747e372d1f3fd"],"text":"","text_display":""},{"cnt":[[245,896],[939,896],[939,947],[245,947]],"region":{"top_left_x":244,"top_left_y":895,"width":695,"height":53},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24e9bc7742e74311a8e747e372d1f3fd","type":"text","conversion_output":true,"parent_id":"6e5b8400e83849c38a01266106110b3e","text":"9.3.3 Sample size with power justification","text_display":"\n\n\\subsection*{9.3.3 Sample size with power justification}","confidence":1,"confidence_rate":1},{"cnt":[[245,941],[1880,941],[1880,990],[245,990]],"region":{"top_left_x":244,"top_left_y":941,"width":1636,"height":50},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a49df1f658e14306825909ac16872071","type":"text","conversion_output":true,"text":"A total of approximately 550 eligible patients will be randomized to the 2 arms (at least 275 patients on","text_display":"\n\nA total of approximately 550 eligible patients will be randomized to the 2 arms (at least 275 patients on","confidence":1,"confidence_rate":1},{"cnt":[[245,986],[1880,986],[1880,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":986,"width":1636,"height":48},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17328104012145b19b2ca52fff9a2d44","type":"text","conversion_output":true,"text":"each arm). Patients will be followed for infection outcome data until criteria in Section 8.3 has been met","text_display":" each arm). Patients will be followed for infection outcome data until criteria in Section 8.3 has been met","confidence":1,"confidence_rate":1},{"cnt":[[245,1027],[1420,1027],[1420,1076],[245,1076]],"region":{"top_left_x":244,"top_left_y":1026,"width":1177,"height":51},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb363e5fe9c2410d92863ef97cf3a9c2","type":"text","conversion_output":true,"text":"unless the patient is off study per Section 8.2 prior to meeting criteria in 8.3.","text_display":" unless the patient is off study per Section 8.2 prior to meeting criteria in 8.3.","confidence":0.96484375,"confidence_rate":0.9995979560340227},{"cnt":[[245,1104],[1880,1104],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1104,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"043724aab12641b486d2627ebf04146d","type":"text","conversion_output":true,"text":"Since the current AAML1031 proposal plans 4 courses of chemotherapy with about 1 month duration for","text_display":"\n\nSince the current AAML1031 proposal plans 4 courses of chemotherapy with about 1 month duration for","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1880,1147],[1880,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1147,"width":1636,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52ae16e58b12430e9919a357f15d9bc7","type":"text","conversion_output":true,"text":"each course, it implies that likely many study participants will be followed for IFI for about 5 months.","text_display":" each course, it implies that likely many study participants will be followed for IFI for about 5 months.","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1880,1195],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1194,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9b13686bac04536b397fc556d9de6f0","type":"text","conversion_output":true,"text":"The power calculation assumes an IFI incidence in the fluconazole group of \\(8 \\%\\) and an IFI incidence in","text_display":" The power calculation assumes an IFI incidence in the fluconazole group of \\(8 \\%\\) and an IFI incidence in","confidence":0.9990236759185791,"confidence_rate":0.9999910385631244},{"cnt":[[245,1238],[1882,1238],[1882,1285],[245,1285]],"region":{"top_left_x":244,"top_left_y":1237,"width":1639,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5ca0d5c11254ee08ceeca3e12d80f39","type":"text","conversion_output":true,"text":"the caspofungin treatment groups of \\(2 \\%\\) at 5 months. The hazard ratio is 0.24 . We assume up to \\(10 \\%\\) of","text_display":" the caspofungin treatment groups of \\(2 \\%\\) at 5 months. The hazard ratio is 0.24 . 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It is estimated that up to \\(25 \\%\\) of patients treated on or per AAML1031 may go","text_display":" disease, relapse, or death. It is estimated that up to \\(25 \\%\\) of patients treated on or per AAML1031 may go","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[245,1369],[1880,1369],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1368,"width":1636,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c58018be3bd541b681c9581b2af16d00","type":"text","conversion_output":true,"text":"to SCT prior to finishing all 4 courses. Therefore, altogether up to \\(35 \\%\\) patients may not be followed until","text_display":" to SCT prior to finishing all 4 courses. Therefore, altogether up to \\(35 \\%\\) patients may not be followed until","confidence":1,"confidence_rate":1},{"cnt":[[245,1414],[1880,1414],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fffdd2e128ff4a14bc3b29704f632ef4","type":"text","conversion_output":true,"text":"the end of 5 months for IFI. With at least 275 patients on each arm, a planned 5 -month follow up on each","text_display":" the end of 5 months for IFI. With at least 275 patients on each arm, a planned 5 -month follow up on each","confidence":0.908247709274292,"confidence_rate":0.999191603147299},{"cnt":[[245,1457],[1880,1457],[1880,1504],[245,1504]],"region":{"top_left_x":244,"top_left_y":1456,"width":1636,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfa657bf28a9444cb191f85c06c2c16c","type":"text","conversion_output":true,"text":"patient and up to \\(35 \\%\\) patients being censored by 5 months, we have about \\(80 \\%\\) power to detect the","text_display":" patient and up to \\(35 \\%\\) patients being censored by 5 months, we have about \\(80 \\%\\) power to detect the","confidence":1,"confidence_rate":1},{"cnt":[[245,1502],[1880,1502],[1880,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1501,"width":1636,"height":49},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33491758b6ca4d53811dfa05acfd54f7","type":"text","conversion_output":true,"text":"expected difference in time-to-IFI curves between the 2 arms ( \\(8 \\%\\) vs. \\(2 \\%\\) at 5 months) in a log rank test","text_display":" expected difference in time-to-IFI curves between the 2 arms ( \\(8 \\%\\) vs. \\(2 \\%\\) at 5 months) in a log rank test","confidence":0.9681134263519198,"confidence_rate":0.9997322174916524},{"cnt":[[245,1543],[1880,1543],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2cd3a3d383d4b84b5772ea89c5ec78c","type":"text","conversion_output":true,"text":"with 2 -sided alpha level of 0.05 . In the calculation, both failure and censoring are assumed to follow an","text_display":" with 2 -sided alpha level of 0.05 . In the calculation, both failure and censoring are assumed to follow an","confidence":0.94677734375,"confidence_rate":0.99953662153775},{"cnt":[[245,1590],[1878,1590],[1878,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1589,"width":1634,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba0adc28d36c4afc8d55d90903a01b67","type":"text","conversion_output":true,"text":"exponential distribution during the 5 months. The majority of the censoring events prior to 5 months are","text_display":" exponential distribution during the 5 months. The majority of the censoring events prior to 5 months are","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,1633],[1880,1633],[1880,1680],[245,1680]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":49},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8a6d2111b6b4970bec1177be56b9fd5","type":"text","conversion_output":true,"text":"expected to be due to SCT which likely occur later in the 5 months, so the exponential censoring","text_display":" expected to be due to SCT which likely occur later in the 5 months, so the exponential censoring","confidence":1,"confidence_rate":1},{"cnt":[[245,1676],[1841,1676],[1841,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1675,"width":1598,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"061b8443db354c31ad7fa12a2bf28eff","type":"text","conversion_output":true,"text":"distribution might not be a very good approximation but should be conservative in power consideration.","text_display":" distribution might not be a very good approximation but should be conservative in power consideration.","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[1878,1753],[1878,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1753,"width":1634,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2afd01fbfe974a208525355802a234d3","type":"text","conversion_output":true,"text":"The assumed baseline incidence of IFI of \\(8 \\%\\) at 5 months is based on data reported in previous studies.","text_display":"\n\nThe assumed baseline incidence of IFI of \\(8 \\%\\) at 5 months is based on data reported in previous studies.","confidence":0.9931781210470945,"confidence_rate":0.9999394243627501},{"cnt":[[245,1796],[1880,1796],[1880,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1796,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b8ebef196e349dda31a442828807f56","type":"text","conversion_output":true,"text":"CCG protocol 2961 found a \\(13 \\%\\) incidence of IFI. The rate of microbiologically documented sterile site","text_display":" CCG protocol 2961 found a \\(13 \\%\\) incidence of IFI. The rate of microbiologically documented sterile site","confidence":0.9137801323086023,"confidence_rate":0.9991952767142462},{"cnt":[[245,1839],[1880,1839],[1880,1886],[245,1886]],"region":{"top_left_x":244,"top_left_y":1839,"width":1636,"height":48},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"167564dbd6fe4b4694f7619ca04b515e","type":"text","conversion_output":true,"text":"fungal infections documented on AAML0531 is \\(12 \\pm 2 \\%\\) as of April 2010; not all of these would meet","text_display":" fungal infections documented on AAML0531 is \\(12 \\pm 2 \\%\\) as of April 2010; not all of these would meet","confidence":0.9970715045928955,"confidence_rate":0.9999715266981888},{"cnt":[[245,1882],[1880,1882],[1880,1931],[245,1931]],"region":{"top_left_x":244,"top_left_y":1882,"width":1636,"height":50},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bccb29e134c040e796955235d8b0a9d9","type":"text","conversion_output":true,"text":"MSG/EORTC criteria as proven/probable IFIs. In the power calculation, the onset of IFI in both groups","text_display":" MSG/EORTC criteria as proven/probable IFIs. In the power calculation, the onset of IFI in both groups","confidence":1,"confidence_rate":1},{"cnt":[[245,1927],[1880,1927],[1880,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1927,"width":1636,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b7dc4ac47134c678be85e5cf10b4ba5","type":"text","conversion_output":true,"text":"over the 5 -month period is assumed to follow an exponential distribution and is \\(8 \\%\\) and \\(2 \\%\\) for","text_display":" over the 5 -month period is assumed to follow an exponential distribution and is \\(8 \\%\\) and \\(2 \\%\\) for","confidence":0.99365234375,"confidence_rate":0.9999410398096767},{"cnt":[[245,1972],[1882,1972],[1882,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1972,"width":1639,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd7814ab947244cdaa84607a8d77dadd","type":"text","conversion_output":true,"text":"fluconazole and caspofungin at 5 months respectively. Under such exponential models, the incidence of","text_display":" fluconazole and caspofungin at 5 months respectively. Under such exponential models, the incidence of","confidence":1,"confidence_rate":1},{"cnt":[[245,2015],[1880,2015],[1880,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2015,"width":1636,"height":50},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b9a42c5ab3d4078b901b0e465009eb7","type":"text","conversion_output":true,"text":"over 5 months is approximately even, about \\(1.6 \\%\\) per month for fluconazole and \\(0.4 \\%\\) per month for","text_display":" over 5 months is approximately even, about \\(1.6 \\%\\) per month for fluconazole and \\(0.4 \\%\\) per month for","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[449,2058],[449,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":206,"height":50},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c553ab1b25fd438684f7d1f2450665d2","type":"text","conversion_output":true,"text":"caspofungin.","text_display":" caspofungin.","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[1880,2136],[1880,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2135,"width":1636,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7f94374b0a345b49aad44ac75a0233e","type":"text","conversion_output":true,"text":"In this setting, we have a potential competing risk issue but its impact on estimating the risk for IFI","text_display":"\n\nIn this setting, we have a potential competing risk issue but its impact on estimating the risk for IFI","confidence":1,"confidence_rate":1},{"cnt":[[245,2179],[1880,2179],[1880,2228],[245,2228]],"region":{"top_left_x":244,"top_left_y":2178,"width":1636,"height":50},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c1cbe666ab248d9b739c717b301d667","type":"text","conversion_output":true,"text":"should be minimal. We expect that majority of the censoring for IFI prior to the study completion are due","text_display":" should be minimal. We expect that majority of the censoring for IFI prior to the study completion are due","confidence":1,"confidence_rate":1},{"cnt":[[245,2226],[1880,2226],[1880,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2225,"width":1636,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e3789074c2b43eda398232d28c5bf87","type":"text","conversion_output":true,"text":"to SCT or relapsed/refractory disease; the occurrence of such events are likely independent of the risk for","text_display":" to SCT or relapsed/refractory disease; the occurrence of such events are likely independent of the risk for","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[1880,2269],[1880,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2268,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12900399720e479d902cc4024b0317fd","type":"text","conversion_output":true,"text":"IFI should the patient continue on the AML therapy, and can be considered true censoring events in the","text_display":" IFI should the patient continue on the AML therapy, and can be considered true censoring events in the","confidence":1,"confidence_rate":1},{"cnt":[[245,2312],[1880,2312],[1880,2359],[245,2359]],"region":{"top_left_x":244,"top_left_y":2311,"width":1636,"height":48},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6c3456ab9b74c2bb1205e58be5ed5cb","type":"text","conversion_output":true,"text":"power consideration above. On the other hand, death prior to any other event constitutes a competing risk","text_display":" power consideration above. On the other hand, death prior to any other event constitutes a competing risk","confidence":1,"confidence_rate":1},{"cnt":[[245,2355],[1880,2355],[1880,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2354,"width":1636,"height":48},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"267c5ffd1e07434ea602035797eb14ca","type":"text","conversion_output":true,"text":"for IFI, but we expect such deaths to be rare and will not likely exceed \\(5 \\%\\) during the first 5 months; the","text_display":" for IFI, but we expect such deaths to be rare and will not likely exceed \\(5 \\%\\) during the first 5 months; the","confidence":0.9941432476043701,"confidence_rate":0.9999497963847676},{"cnt":[[245,2400],[1880,2400],[1880,2447],[245,2447]],"region":{"top_left_x":244,"top_left_y":2399,"width":1636,"height":49},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b0d7b18b4e54289a4ce7f74c536c33a","type":"text","conversion_output":true,"text":"impact that it has on estimating the risk of IFI by treating it as censored is minimal. Recently there have","text_display":" impact that it has on estimating the risk of IFI by treating it as censored is minimal. Recently there have","confidence":1,"confidence_rate":1},{"cnt":[[245,2443],[1880,2443],[1880,2490],[245,2490]],"region":{"top_left_x":244,"top_left_y":2442,"width":1636,"height":49},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a31378bed764849ba150610505bd02a","type":"text","conversion_output":true,"text":"been some developments on sample size considerations under competing risk setting for either the","text_display":" been some developments on sample size considerations under competing risk setting for either the","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[614,2582],[614,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":371,"height":42},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bb404af6b7e45599cf8c7e2a89cac0a","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1880,2582],[1880,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":132,"height":46},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e51ab1ba20d74e3c8224b8102852e8f8","type":"page_info","conversion_output":false,"text":"Page 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protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.9761475823079309,"confidence_rate":0.999698276869841},{"cnt":[[1691,125],[1880,125],[1880,168],[1691,168]],"region":{"top_left_x":1690,"top_left_y":124,"width":190,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbdc4eb4c66c42d096a8c2d499684e0d","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[365,155],[365,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":104,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4b39b974fe724fc584b3fe02ed97d654","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,247],[1882,247],[1882,299],[245,299]],"region":{"top_left_x":244,"top_left_y":247,"width":1639,"height":52},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0fb75b495034c20a4a1b8b2cf2d7d10","type":"text","conversion_output":true,"text":"proportional cause-specific hazard model \\({ }^{49}\\) or proportional sub-distribution hazard model. \\({ }^{50}\\) However","text_display":"\nproportional cause-specific hazard model \\({ }^{49}\\) or proportional sub-distribution hazard model. \\({ }^{50}\\) However","confidence":1,"confidence_rate":1},{"cnt":[[245,294],[1880,294],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":294,"width":1636,"height":48},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72b15bc0cdb64c788b1cb22fbd336510","type":"text","conversion_output":true,"text":"since the cumulative incidence of IFI under competing risk setting also involves the cause specific hazard","text_display":" since the cumulative incidence of IFI under competing risk setting also involves the cause specific hazard","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c75fd5a8367f4fa0bf8036910215222f","type":"text","conversion_output":true,"text":"of the competing risk, the interpretation of some of the planning parameters in these settings can be","text_display":" of the competing risk, the interpretation of some of the planning parameters in these settings can be","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1880,382],[1880,430],[245,430]],"region":{"top_left_x":244,"top_left_y":382,"width":1636,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6be4fb10e3714eff9fcb136bc957ad6c","type":"text","conversion_output":true,"text":"complicated and additional assumptions about the competing risk need to be made; it is also not yet well","text_display":" complicated and additional assumptions about the competing risk need to be made; it is also not yet well","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d62ff58d4a94dc09385f31039d0e51d","type":"text","conversion_output":true,"text":"understood which model is better in different real settings. Given the fact that the true competing risk here","text_display":" understood which model is better in different real settings. Given the fact that the true competing risk here","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1880,471],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1636,"height":48},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7759daff6aed4b60a505b0c2245336b6","type":"text","conversion_output":true,"text":"is rare, we still use standard survival analyses for sample size considerations, but will perform competing","text_display":" is rare, we still use standard survival analyses for sample size considerations, but will perform competing","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1680,516],[1680,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1437,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3cc5bded3f545d09e8ecd6549377dd2","type":"text","conversion_output":true,"text":"risk analyses on the study data to ensure that it does not change the results of the comparison.","text_display":" risk analyses on the study data to ensure that it does not change the results of the comparison.","confidence":1,"confidence_rate":1},{"cnt":[[236,593],[574,593],[574,655],[236,655]],"region":{"top_left_x":236,"top_left_y":592,"width":338,"height":64},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38f19dcd3a584927a023f4723a180ca6","type":"section_header","conversion_output":false,"children_ids":["62916b86f01b4366a46f50d406d8aec5"],"text":"","text_display":""},{"cnt":[[245,602],[569,602],[569,651],[245,651]],"region":{"top_left_x":244,"top_left_y":601,"width":326,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62916b86f01b4366a46f50d406d8aec5","type":"text","conversion_output":true,"parent_id":"38f19dcd3a584927a023f4723a180ca6","text":"9.3.4 Analysis Plans","text_display":"\n\n\\subsection*{9.3.4 Analysis Plans}","confidence":1,"confidence_rate":1},{"cnt":[[241,662],[587,662],[587,718],[241,718]],"region":{"top_left_x":240,"top_left_y":661,"width":347,"height":57},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b56d7fc38784f56af40c178dfa6c233","type":"section_header","conversion_output":false,"children_ids":["38409543b4774b57b9323fff5b128969"],"text":"","text_display":""},{"cnt":[[245,666],[582,666],[582,713],[245,713]],"region":{"top_left_x":244,"top_left_y":666,"width":339,"height":48},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38409543b4774b57b9323fff5b128969","type":"text","conversion_output":true,"parent_id":"2b56d7fc38784f56af40c178dfa6c233","text":"Descriptive Analyses","text_display":"\n\n\\section*{Descriptive Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[245,709],[1880,709],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1636,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc0b572265324c199940d54eb5277f36","type":"text","conversion_output":true,"text":"Standard descriptive statistics will be used to describe subjects' baseline characteristics and study","text_display":"\n\nStandard descriptive statistics will be used to describe subjects' baseline characteristics and study","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1880,752],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":51},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3d54930ee044553b593da166c1a8103","type":"text","conversion_output":true,"text":"outcome measures overall and within each treatment group. Summary statistics such as means, standard","text_display":" outcome measures overall and within each treatment group. Summary statistics such as means, standard","confidence":1,"confidence_rate":1},{"cnt":[[245,797],[1880,797],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":797,"width":1636,"height":48},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fc0e58840ea4fb6bf5281cab42e6b1d","type":"text","conversion_output":true,"text":"deviations, medians, and ranges will be produced for all measured variables. The balance of baseline","text_display":" deviations, medians, and ranges will be produced for all measured variables. The balance of baseline","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[1648,842],[1648,889],[245,889]],"region":{"top_left_x":244,"top_left_y":842,"width":1404,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fef000d585c44e39151d9e74bdbcf7c","type":"text","conversion_output":true,"text":"measures across the treatment groups will be examined using appropriate two-sample tests.","text_display":" measures across the treatment groups will be examined using appropriate two-sample tests.","confidence":1,"confidence_rate":1},{"cnt":[[236,924],[1278,924],[1278,982],[236,982]],"region":{"top_left_x":236,"top_left_y":923,"width":1043,"height":59},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd5c6d40edc0449e882ed25128cb72a4","type":"section_header","conversion_output":false,"children_ids":["adc2fd85fe1f4152a7e7bcd152ec37d5"],"text":"","text_display":""},{"cnt":[[243,930],[1274,928],[1274,975],[243,978]],"region":{"top_left_x":242,"top_left_y":928,"width":1033,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"adc2fd85fe1f4152a7e7bcd152ec37d5","type":"text","conversion_output":true,"parent_id":"bd5c6d40edc0449e882ed25128cb72a4","text":"Analysis for Primary Objective and Secondary Clinical Objectives","text_display":"\n\n\\section*{Analysis for Primary Objective and Secondary Clinical Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[245,975],[1880,975],[1880,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":975,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f5e27b97ca04ab5a7ce8fab282ceb45","type":"text","conversion_output":true,"text":"The primary analysis will be based on the principle of intention to treat (i.e., by the treatment assignment","text_display":"\n\nThe primary analysis will be based on the principle of intention to treat (i.e., by the treatment assignment","confidence":0.9990234375,"confidence_rate":0.9999913536688149},{"cnt":[[245,1018],[1882,1018],[1882,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1018,"width":1639,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5259bb270d5e4d818638dbcc0157c0b1","type":"text","conversion_output":true,"text":"of patients at randomization, regardless of subsequent compliance with the assigned treatment). Most of","text_display":" of patients at randomization, regardless of subsequent compliance with the assigned treatment). Most of","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1880,1061],[1880,1109],[245,1109]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c5149a6675f47cfae141b87052c5a6a","type":"text","conversion_output":true,"text":"the events that take patients off IFI follow up prematurely such as going to SCT, relapse/refractory","text_display":" the events that take patients off IFI follow up prematurely such as going to SCT, relapse/refractory","confidence":1,"confidence_rate":1},{"cnt":[[245,1106],[1880,1106],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1106,"width":1636,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3f11f90039e42f3a14160eaa432edda","type":"text","conversion_output":true,"text":"disease, may be considered independent from the risk for IFI; therefore they may be considered as true","text_display":" disease, may be considered independent from the risk for IFI; therefore they may be considered as true","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1880,1147],[1880,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1147,"width":1636,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb21388a637b4dad94e7f4d1d59e152e","type":"text","conversion_output":true,"text":"censoring events. Death before any such censoring events is a competing risk for IFI; however since the","text_display":" censoring events. Death before any such censoring events is a competing risk for IFI; however since the","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1880,1195],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1194,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b93c088afee34f1fb78ac56b5ac8a46e","type":"text","conversion_output":true,"text":"chance of that happening will be rare, expected to be no more than \\(5 \\%\\), the effect of competing risk by","text_display":" chance of that happening will be rare, expected to be no more than \\(5 \\%\\), the effect of competing risk by","confidence":0.9985356330871582,"confidence_rate":0.9999867979236713},{"cnt":[[245,1238],[1880,1238],[1880,1285],[245,1285]],"region":{"top_left_x":244,"top_left_y":1237,"width":1636,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9ef6cb31f12440c913e9f0da784e2ed","type":"text","conversion_output":true,"text":"death as the first event should be minimal. Therefore, we will focus on standard survival analyses but will","text_display":" death as the first event should be minimal. Therefore, we will focus on standard survival analyses but will","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[245,1280],[1878,1280],[1878,1328],[245,1328]],"region":{"top_left_x":244,"top_left_y":1280,"width":1634,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07b9b284bdd545288120b40fdbdf73a3","type":"text","conversion_output":true,"text":"also perform competing risk analyses to check if the results change after we consider death as a","text_display":" also perform competing risk analyses to check if the results change after we consider death as a","confidence":1,"confidence_rate":1},{"cnt":[[245,1326],[1880,1323],[1880,1372],[245,1375]],"region":{"top_left_x":244,"top_left_y":1323,"width":1636,"height":52},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30f6aca57fb5487a8feb63ca1f3b67c5","type":"text","conversion_output":true,"text":"competing risk. In standard survival analyses, patients who go off IFI follow up before developing IFI for","text_display":" competing risk. In standard survival analyses, patients who go off IFI follow up before developing IFI for","confidence":1,"confidence_rate":1},{"cnt":[[245,1369],[1880,1369],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1368,"width":1636,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec8ada1d2ec74bf0a30200f7a362f7ca","type":"text","conversion_output":true,"text":"any reason will be treated as being censored. We will use Kaplan-Meier analyses to evaluate time to any","text_display":" any reason will be treated as being censored. We will use Kaplan-Meier analyses to evaluate time to any","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,1414],[1878,1414],[1878,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1413,"width":1634,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b678a0d281bd41f0acb77cff05bfeb26","type":"text","conversion_output":true,"text":"IFI and log rank test to assess if there is any benefit associated with caspofungin compared to fluconazole.","text_display":" IFI and log rank test to assess if there is any benefit associated with caspofungin compared to fluconazole.","confidence":0.94677734375,"confidence_rate":0.9995161230273313},{"cnt":[[245,1457],[1880,1457],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1456,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5bea0e95c5b448092bda1f63e78f3cf","type":"text","conversion_output":true,"text":"For competing risk analyses, nonparametric estimate of the cumulative incidence function for IFI will","text_display":" For competing risk analyses, nonparametric estimate of the cumulative incidence function for IFI will","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":51},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"438fc7caaf354812bee9ceb3f744f1a0","type":"text","conversion_output":true,"text":"then be calculated by treating death (if first event) or possibly death plus other events as competing risk","text_display":" then be calculated by treating death (if first event) or possibly death plus other events as competing risk","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1790,1543],[1790,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1542,"width":1546,"height":50},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5990992b206b4946aa06e540df50f750","type":"text","conversion_output":true,"text":"for IFI; Gray's test \\({ }^{51}\\) will be used to compare the cumulative incidence function between the 2 arms.","text_display":" for IFI; Gray's test \\({ }^{51}\\) will be used to compare the cumulative incidence function between the 2 arms.","confidence":0.99951171875,"confidence_rate":0.9999958958025558},{"cnt":[[245,1633],[1880,1633],[1880,1680],[245,1680]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":49},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6cac6ccb17d94908b3c5b52f4ad74b66","type":"text","conversion_output":true,"text":"Similar standard survival analyses and competing risk analyses will be performed for secondary","text_display":"\n\nSimilar standard survival analyses and competing risk analyses will be performed for secondary","confidence":1,"confidence_rate":1},{"cnt":[[245,1676],[1884,1676],[1884,1723],[245,1723]],"region":{"top_left_x":244,"top_left_y":1675,"width":1641,"height":49},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e068146b7d1140b8a3647e0a289fee48","type":"text","conversion_output":true,"text":"objectives 1-3 and the exploratory endpoint. For the secondary objective of time to development of","text_display":" objectives 1-3 and the exploratory endpoint. For the secondary objective of time to development of","confidence":1,"confidence_rate":1},{"cnt":[[245,1721],[1880,1721],[1880,1766],[245,1766]],"region":{"top_left_x":244,"top_left_y":1720,"width":1636,"height":47},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"560cfa5272434a71a95de103c1b917f1","type":"text","conversion_output":true,"text":"invasive aspergillosis (IA), other IFI will also be considered a competing risk variable for IA in the","text_display":" invasive aspergillosis (IA), other IFI will also be considered a competing risk variable for IA in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1764],[1880,1764],[1880,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1763,"width":1636,"height":49},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75f524e5325d4f8d8cfb38627cdc2d29","type":"text","conversion_output":true,"text":"competing risk analysis. For time to death (by any cause), only standard survival analyses will be","text_display":" competing risk analysis. For time to death (by any cause), only standard survival analyses will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1809],[1880,1809],[1880,1856],[245,1856]],"region":{"top_left_x":244,"top_left_y":1808,"width":1636,"height":49},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25b994ae93504147bb8c02ffc301344a","type":"text","conversion_output":true,"text":"performed. The total days of empiric antifungal therapy will also be compared between the 2 arms using","text_display":" performed. The total days of empiric antifungal therapy will also be compared between the 2 arms using","confidence":1,"confidence_rate":1},{"cnt":[[245,1852],[754,1852],[754,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1851,"width":511,"height":47},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91e6b6368ac74398b3ffa1316b30bd57","type":"text","conversion_output":true,"text":"t-test or Wilcoxon rank sum test.","text_display":" t-test or Wilcoxon rank sum test.","confidence":1,"confidence_rate":1},{"cnt":[[236,1921],[924,1921],[924,1979],[236,1979]],"region":{"top_left_x":236,"top_left_y":1920,"width":688,"height":59},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71230a0c7be342789406ab20beade553","type":"section_header","conversion_output":false,"children_ids":["954d073a0c54440aa0026f51c3d4963f"],"text":"","text_display":""},{"cnt":[[245,1929],[917,1929],[917,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1929,"width":674,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"954d073a0c54440aa0026f51c3d4963f","type":"text","conversion_output":true,"parent_id":"71230a0c7be342789406ab20beade553","text":"Analysis of GM and beta-D Glucan Assays","text_display":"\n\n\\section*{Analysis of GM and beta-D Glucan Assays}","confidence":1,"confidence_rate":1},{"cnt":[[245,1972],[1880,1972],[1880,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1972,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31aa8975793c45279f8dfd6b0ba7c692","type":"text","conversion_output":true,"text":"Sensitivity, specificity, positive predictive value, and negative predictive value of the GM assay and beta-","text_display":"\n\nSensitivity, specificity, positive predictive value, and negative predictive value of the GM assay and beta","confidence":1,"confidence_rate":1},{"cnt":[[245,2015],[1880,2015],[1880,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2015,"width":1636,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce33f04dac7948c7b962c9adec6c887f","type":"text","conversion_output":true,"text":"D glucan assay will be determined using standard formulas and EORTC/MSG criteria as the gold","text_display":"D glucan assay will be determined using standard formulas and EORTC/MSG criteria as the gold","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1717,2058],[1717,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":1473,"height":50},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b998c8fb0de04610bd23ad50f153a96b","type":"text","conversion_output":true,"text":"standard. Please see Section 13.8 for additional statistical considerations for this secondary aim.","text_display":" standard. Please see Section 13.8 for additional statistical considerations for this secondary aim.","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[958,2136],[958,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2135,"width":715,"height":50},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41e287188db24fc5a4493761a1438294","type":"text","conversion_output":true,"text":"SNP Analysis in Genes Involved in Immunity","text_display":"\n\nSNP Analysis in Genes Involved in Immunity","confidence":1,"confidence_rate":1},{"cnt":[[245,2179],[1880,2179],[1880,2228],[245,2228]],"region":{"top_left_x":244,"top_left_y":2178,"width":1636,"height":50},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb6aeefcc3d9473881d6c57c66b73294","type":"text","conversion_output":true,"text":"We will perform haplotype analysis using previously established methods for unrelated subjects. \\({ }^{52,53}\\) To","text_display":"\nWe will perform haplotype analysis using previously established methods for unrelated subjects. \\({ }^{52,53}\\) To","confidence":1,"confidence_rate":1},{"cnt":[[245,2226],[1880,2226],[1880,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2225,"width":1636,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd4d3132ea784be6891394366b920642","type":"text","conversion_output":true,"text":"deal with possible false positive or negative results, we will perform the following. First, in order to","text_display":" deal with possible false positive or negative results, we will perform the following. First, in order to","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[1880,2269],[1880,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2268,"width":1636,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcffecf490c04860b616f5547bc9298f","type":"text","conversion_output":true,"text":"handle the concern of multiple testing, we will adjust the \\(P\\) value required for statistical significance by","text_display":" handle the concern of multiple testing, we will adjust the \\(P\\) value required for statistical significance by","confidence":1,"confidence_rate":1},{"cnt":[[245,2312],[1880,2312],[1880,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2311,"width":1636,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"160f6f5691d04d1d86b1028ff2543ee9","type":"text","conversion_output":true,"text":"the false discovery rate, which is an approach to multiple testing that is a compromise between unadjusted","text_display":" the false discovery rate, which is an approach to multiple testing that is a compromise between unadjusted","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,2355],[1880,2355],[1880,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2354,"width":1636,"height":48},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5790f9954f8745249494e4dd32cfed22","type":"text","conversion_output":true,"text":"tests of significance and more traditional, but too conservative Bonferonni adjustment. \\({ }^{54}\\) Second, to","text_display":" tests of significance and more traditional, but too conservative Bonferonni adjustment. \\({ }^{54}\\) Second, to","confidence":1,"confidence_rate":1},{"cnt":[[245,2398],[1880,2398],[1880,2447],[245,2447]],"region":{"top_left_x":244,"top_left_y":2397,"width":1636,"height":51},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9c9e0e8ab2c468dbe82ea68f4790ee1","type":"text","conversion_output":true,"text":"handle the potential for population stratification, all analyses will be performed with and without","text_display":" handle the potential for population stratification, all analyses will be performed with and without","confidence":1,"confidence_rate":1},{"cnt":[[245,2445],[1880,2445],[1880,2490],[245,2490]],"region":{"top_left_x":244,"top_left_y":2444,"width":1636,"height":47},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"671b104525754de9a458f8febb6ce824","type":"text","conversion_output":true,"text":"adjustment by ethnicity. We will use Kaplan-Meier analyses to evaluate time to any IFI, and determine","text_display":" adjustment by ethnicity. We will use Kaplan-Meier analyses to evaluate time to any IFI, and determine","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[612,2582],[612,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":369,"height":42},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6ef9dc32441492baa015ed7cd61c838","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1876,2582],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":128,"height":46},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10cc9289192f43548152e58fbbefad2d","type":"page_info","conversion_output":false,"text":"Page 33","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"30d0fca4-08d7-48bb-b63f-1324b67d52fd-34","page":34,"lines":[{"cnt":[[262,86],[436,86],[436,122],[262,122]],"region":{"top_left_x":262,"top_left_y":85,"width":175,"height":38},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5a36c1d58fe84c388e10c7147972f9f7","type":"page_info","conversion_output":false,"text":"CHILDREN'S","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[262,120],[417,120],[417,157],[262,157]],"region":{"top_left_x":262,"top_left_y":120,"width":155,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"02ae83b9928140e7868b6b4446ef6b05","type":"page_info","conversion_output":false,"text":"ONCOLOGY","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[494,129],[1497,129],[1497,170],[494,170]],"region":{"top_left_x":494,"top_left_y":128,"width":1004,"height":42},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"48837f3f2c524d8f88cec1e5b0cf94ae","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.9761475823079309,"confidence_rate":0.999698276869841},{"cnt":[[1691,125],[1880,125],[1880,170],[1691,170]],"region":{"top_left_x":1690,"top_left_y":124,"width":190,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87593eab9f8e46da9bab8ec8843effdb","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[367,155],[367,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":106,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"27d4fe517fbc430aa652ecb2d3331bd2","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":0.99755859375,"confidence_rate":0.9997555907386334},{"cnt":[[245,249],[1880,249],[1880,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1636,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e503c3df06d41f388d5f8911f5e3355","type":"text","conversion_output":true,"text":"the impact of candidate gene SNPs using the log rank test. For the exploratory analysis on the relationship","text_display":"\nthe impact of candidate gene SNPs using the log rank test. For the exploratory analysis on the relationship","confidence":1,"confidence_rate":1},{"cnt":[[245,294],[1880,294],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":294,"width":1636,"height":48},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11f405df12e74895b7cfae011430dd5f","type":"text","conversion_output":true,"text":"between IFI and the identified SNPs in the candidate genes, study participants will be grouped based on","text_display":" between IFI and the identified SNPs in the candidate genes, study participants will be grouped based on","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11c07fdcf9f24b08839f6991021afe49","type":"text","conversion_output":true,"text":"the genotype of specific \\(\\operatorname{SNP}(s)\\). If the primary analysis suggests no difference in IFI between","text_display":" the genotype of specific \\(\\operatorname{SNP}(s)\\). If the primary analysis suggests no difference in IFI between","confidence":0.5064651390380277,"confidence_rate":0.9936026283780275},{"cnt":[[245,382],[1880,382],[1880,430],[245,430]],"region":{"top_left_x":244,"top_left_y":382,"width":1636,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad7d6026cef74e3bacef724d3922f752","type":"text","conversion_output":true,"text":"caspofungin and fluconazole, standard log rank analysis will be used to compare the time to IFI between","text_display":" caspofungin and fluconazole, standard log rank analysis will be used to compare the time to IFI between","confidence":0.98291015625,"confidence_rate":0.999840405694678},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa7556990dad4a2ea1373b4f59d74f96","type":"text","conversion_output":true,"text":"patient groups defined by the \\(\\operatorname{SNP}( s )\\); stratified log rank test adjusting for treatment arm will be","text_display":" patient groups defined by the \\(\\operatorname{SNP}( s )\\); stratified log rank test adjusting for treatment arm will be","confidence":0.3643244018549012,"confidence_rate":0.9911043108821214},{"cnt":[[245,471],[1747,471],[1747,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1503,"height":48},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41ebbab0bff3448c94cae47d976ac562","type":"text","conversion_output":true,"text":"considered if the data suggest a treatment difference on IFI between caspofungin and fluconazole.","text_display":" considered if the data suggest a treatment difference on IFI between caspofungin and fluconazole.","confidence":1,"confidence_rate":1},{"cnt":[[245,546],[1880,546],[1880,593],[245,593]],"region":{"top_left_x":244,"top_left_y":545,"width":1636,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b6c6c47df964c07b0ea518621642d97","type":"text","conversion_output":true,"text":"In developing a clinical prediction model for IFI, the outcome is time to IFI and the predictors can be","text_display":"\n\nIn developing a clinical prediction model for IFI, the outcome is time to IFI and the predictors can be","confidence":1,"confidence_rate":1},{"cnt":[[245,591],[1880,591],[1880,638],[245,638]],"region":{"top_left_x":244,"top_left_y":590,"width":1636,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"adddfe7c37cf4aa5933eab00c5568002","type":"text","conversion_output":true,"text":"demographic factors, clinical factors, co-morbid conditions, and SNPs. Standard survival analysis such as","text_display":" demographic factors, clinical factors, co-morbid conditions, and SNPs. Standard survival analysis such as","confidence":1,"confidence_rate":1},{"cnt":[[245,636],[1880,636],[1880,681],[245,681]],"region":{"top_left_x":244,"top_left_y":635,"width":1636,"height":47},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53802c5fad12446ea50349eb34cca73b","type":"text","conversion_output":true,"text":"Cox model (or competing risk analyses modeling the cause-specific hazard or cumulative incidence","text_display":" Cox model (or competing risk analyses modeling the cause-specific hazard or cumulative incidence","confidence":1,"confidence_rate":1},{"cnt":[[245,679],[1880,679],[1880,724],[245,724]],"region":{"top_left_x":244,"top_left_y":678,"width":1636,"height":47},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"078c3603dcc3496790bbbfeefef84af9","type":"text","conversion_output":true,"text":"function, if needed) will be used to build predictive models. Unlike an explanatory model, inclusion of","text_display":" function, if needed) will be used to build predictive models. Unlike an explanatory model, inclusion of","confidence":1,"confidence_rate":1},{"cnt":[[245,722],[1880,722],[1880,767],[245,767]],"region":{"top_left_x":244,"top_left_y":721,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"600842be9251435bbf7ee0739afffb4e","type":"text","conversion_output":true,"text":"variables into the predictive model will depend only on its ability to improve the prediction of the","text_display":" variables into the predictive model will depend only on its ability to improve the prediction of the","confidence":1,"confidence_rate":1},{"cnt":[[245,765],[1880,765],[1880,814],[245,814]],"region":{"top_left_x":244,"top_left_y":764,"width":1636,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d77bcdf545f34b8a959987737febca80","type":"text","conversion_output":true,"text":"outcome and does not necessarily have to be based on biologic plausibility (although plausibility could","text_display":" outcome and does not necessarily have to be based on biologic plausibility (although plausibility could","confidence":1,"confidence_rate":1},{"cnt":[[245,812],[1880,812],[1880,857],[245,857]],"region":{"top_left_x":244,"top_left_y":812,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7aa66062eac04e3da287b17b03be0927","type":"text","conversion_output":true,"text":"make a prediction rule more accessible to clinicians). On the other hand, a clinically useful predictive","text_display":" make a prediction rule more accessible to clinicians). On the other hand, a clinically useful predictive","confidence":1,"confidence_rate":1},{"cnt":[[245,855],[1880,855],[1880,900],[245,900]],"region":{"top_left_x":244,"top_left_y":855,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5bf78c558f38407ca5966a0776e7703c","type":"text","conversion_output":true,"text":"model also needs to be practical in that the variables must be available in most clinical settings. We will","text_display":" model also needs to be practical in that the variables must be available in most clinical settings. We will","confidence":1,"confidence_rate":1},{"cnt":[[245,898],[1880,898],[1880,947],[245,947]],"region":{"top_left_x":244,"top_left_y":898,"width":1636,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cac5b34419544bed9f3aae43db7260b5","type":"text","conversion_output":true,"text":"take into account these factors in developing the predictive models, and internal cross-validation","text_display":" take into account these factors in developing the predictive models, and internal cross-validation","confidence":1,"confidence_rate":1},{"cnt":[[245,941],[1085,941],[1085,990],[245,990]],"region":{"top_left_x":244,"top_left_y":941,"width":841,"height":50},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd09f676901c4034b710d6afb09f8edc","type":"text","conversion_output":true,"text":"techniques will be considered in assessing the models.","text_display":" techniques will be considered in assessing the models.","confidence":1,"confidence_rate":1},{"cnt":[[236,1010],[683,1010],[683,1070],[236,1070]],"region":{"top_left_x":236,"top_left_y":1009,"width":448,"height":61},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bed3a37fb8c548aaba5b311bd6a169a4","type":"section_header","conversion_output":false,"children_ids":["dfb2436aa573481cb1ccafdbaa524ebb"],"text":"","text_display":""},{"cnt":[[245,1016],[677,1016],[677,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1016,"width":433,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dfb2436aa573481cb1ccafdbaa524ebb","type":"text","conversion_output":true,"parent_id":"bed3a37fb8c548aaba5b311bd6a169a4","text":"9.3.5 Interim Monitoring","text_display":"\n\n\\subsection*{9.3.5 Interim Monitoring}","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1880,1061],[1880,1109],[245,1109]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bddd44de4d2e4362b3351ffb92604684","type":"text","conversion_output":true,"text":"Study data will be reviewed by DSMC twice a year during the first 2 years of study activation, and once a","text_display":"\n\nStudy data will be reviewed by DSMC twice a year during the first 2 years of study activation, and once a","confidence":1,"confidence_rate":1},{"cnt":[[245,1106],[1880,1106],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1106,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84c34967eca24ad5af33902a56173884","type":"text","conversion_output":true,"text":"year thereafter upon their approval if the study goes smoothly. We plan two formal interim efficacy","text_display":" year thereafter upon their approval if the study goes smoothly. We plan two formal interim efficacy","confidence":1,"confidence_rate":1},{"cnt":[[245,1152],[1880,1152],[1880,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1151,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18ef72a9bc884946982376f6d613e8ca","type":"text","conversion_output":true,"text":"analyses comparing treatment outcomes between the 2 arms, after approximately one third and two thirds","text_display":" analyses comparing treatment outcomes between the 2 arms, after approximately one third and two thirds","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1880,1195],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1194,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a3ce07840294f23af9b50d7747f50f9","type":"text","conversion_output":true,"text":"of the patients have completed study treatment and IFI observation. The endpoints for the interim","text_display":" of the patients have completed study treatment and IFI observation. The endpoints for the interim","confidence":1,"confidence_rate":1},{"cnt":[[245,1238],[1880,1238],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1237,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f5f3a65a0a04384bfbf60dd1582b787","type":"text","conversion_output":true,"text":"analyses include time to the following individual event: IFI, invasive aspergillosis, death. Log rank test","text_display":" analyses include time to the following individual event: IFI, invasive aspergillosis, death. Log rank test","confidence":1,"confidence_rate":1},{"cnt":[[245,1280],[1878,1280],[1878,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1280,"width":1634,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cac5ec82ab2045738a1238a5a277c87d","type":"text","conversion_output":true,"text":"will be the primary method for these interim analyses; monitoring boundary for the primary endpoint on","text_display":" will be the primary method for these interim analyses; monitoring boundary for the primary endpoint on","confidence":1,"confidence_rate":1},{"cnt":[[245,1323],[1880,1323],[1880,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1323,"width":1636,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c04c8bc1b149426683802c559dd3fde2","type":"text","conversion_output":true,"text":"IFI will be based on Lan-Demet's method with spending function \\(\\alpha\\) t. \\({ }^{2,55}\\) Competing risk analyses such as","text_display":" IFI will be based on Lan-Demet's method with spending function \\(\\alpha\\) t. \\({ }^{2,55}\\) Competing risk analyses such as","confidence":0.9694433212280273,"confidence_rate":0.9997456613014815},{"cnt":[[245,1371],[1878,1371],[1878,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1370,"width":1634,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"653f72442fdb4464ae50e116da928f8e","type":"text","conversion_output":true,"text":"estimating the cumulative incidence of the event and Gray's test for IFI or IA will be performed as well to","text_display":" estimating the cumulative incidence of the event and Gray's test for IFI or IA will be performed as well to","confidence":1,"confidence_rate":1},{"cnt":[[245,1414],[1880,1414],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef7f1fab1c8d45df9422960b061faeae","type":"text","conversion_output":true,"text":"check that corresponding competing risk analyses do not suggest a different conclusion than the standard","text_display":" check that corresponding competing risk analyses do not suggest a different conclusion than the standard","confidence":0.99755859375,"confidence_rate":0.9999775746428119},{"cnt":[[245,1457],[526,1457],[526,1504],[245,1504]],"region":{"top_left_x":244,"top_left_y":1456,"width":283,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"797b5ec2db72444893d5b72e06b1c0a9","type":"text","conversion_output":true,"text":"survival analyses.","text_display":" survival analyses.","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1880,1543],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b206870e991487fb47c688c8e20431a","type":"text","conversion_output":true,"text":"Informal interim safety analyses will also be performed at each DSMC review on the observed adverse","text_display":"\n\nInformal interim safety analyses will also be performed at each DSMC review on the observed adverse","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[1880,1590],[1880,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1589,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0eba14f5bd99441eadefe7547426f6f3","type":"text","conversion_output":true,"text":"events between the 2 arms. This analysis will include all patients who receive at least one dose of study","text_display":" events between the 2 arms. This analysis will include all patients who receive at least one dose of study","confidence":1,"confidence_rate":1},{"cnt":[[245,1633],[1880,1633],[1880,1680],[245,1680]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":49},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53e181b922ea4f979d6d4b3df75be70d","type":"text","conversion_output":true,"text":"medication. The proportion of patients experiencing any grade 4 or higher non-hematological adverse","text_display":" medication. The proportion of patients experiencing any grade 4 or higher non-hematological adverse","confidence":1,"confidence_rate":1},{"cnt":[[245,1676],[1880,1676],[1880,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1675,"width":1636,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1c1ce93910e42c8a001b2abb6dec3a7","type":"text","conversion_output":true,"text":"event will be compared between the 2 groups using chi-square tests. For this monitoring, each test will be","text_display":" event will be compared between the 2 groups using chi-square tests. For this monitoring, each test will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1721],[1880,1721],[1880,1768],[245,1768]],"region":{"top_left_x":244,"top_left_y":1720,"width":1636,"height":49},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58ee519777b14ea29b5b8d98c48f0e3b","type":"text","conversion_output":true,"text":"at two-sided level of 0.05 without adjustment for multiple testing, to ensure us being alerted by any","text_display":" at two-sided level of 0.05 without adjustment for multiple testing, to ensure us being alerted by any","confidence":1,"confidence_rate":1},{"cnt":[[245,1766],[1878,1766],[1878,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1766,"width":1634,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6076d7adb6514076b03b47be87e7ed1f","type":"text","conversion_output":true,"text":"potential difference in adverse events between the 2 arms. 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Alternative specimen vials should never be used as they may","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[647,821],[647,866],[245,866]],"region":{"top_left_x":244,"top_left_y":820,"width":403,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c681f6fe982d4dccbb243070f39d9e7b","type":"text","conversion_output":true,"text":"contribute to false results.","text_display":" contribute to false results.","confidence":1,"confidence_rate":1},{"cnt":[[241,889],[668,889],[668,952],[241,952]],"region":{"top_left_x":240,"top_left_y":889,"width":429,"height":63},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a133cb0204947b1a923dfc6a462a678","type":"section_header","conversion_output":false,"children_ids":["a49a1e5bb75b4a88b888010dbd2e39eb"],"text":"","text_display":""},{"cnt":[[245,896],[664,896],[664,947],[245,947]],"region":{"top_left_x":244,"top_left_y":895,"width":420,"height":53},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a49a1e5bb75b4a88b888010dbd2e39eb","type":"text","conversion_output":true,"parent_id":"4a133cb0204947b1a923dfc6a462a678","text":"13.1.2 Sample Collection","text_display":"\n\n\\subsection*{13.1.2 Sample Collection}","confidence":1,"confidence_rate":1},{"cnt":[[245,941],[1880,941],[1880,990],[245,990]],"region":{"top_left_x":244,"top_left_y":941,"width":1636,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d6b1834c3804ac79b5c5a8c9d6efc95","type":"text","conversion_output":true,"text":"Whole blood samples will be collected twice weekly during the period of neutropenia (until ANC \\(>100\\) -","text_display":"\n\nWhole blood samples will be collected twice weekly during the period of neutropenia (until ANC \\(>100\\) ","confidence":0.6468286514282227,"confidence_rate":0.9960109695591337},{"cnt":[[245,984],[1880,984],[1880,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":983,"width":1636,"height":51},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abe34b6845f347e59fde7a0fa30d19b5","type":"text","conversion_output":true,"text":"\\(500 / \\mu L\\) ). It is suggested that specimens be obtained on Mondays and Thursdays but other days are","text_display":"\\(500 / \\mu L\\) ). It is suggested that specimens be obtained on Mondays and Thursdays but other days are","confidence":0.9863739013671875,"confidence_rate":0.9998668070656267},{"cnt":[[245,1027],[1714,1027],[1714,1079],[245,1079]],"region":{"top_left_x":244,"top_left_y":1026,"width":1471,"height":53},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d91c5b9e72b4bd69eb067505deca85a","type":"text","conversion_output":true,"text":"acceptable if more convenient. A minimum of 2 days should separate each specimen collection.","text_display":" acceptable if more convenient. A minimum of 2 days should separate each specimen collection.","confidence":0.9755859375,"confidence_rate":0.9997528602745455},{"cnt":[[245,1113],[1880,1113],[1880,1167],[245,1167]],"region":{"top_left_x":244,"top_left_y":1112,"width":1636,"height":55},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f95046e5f7b4f828c8d5f3daebe641b","type":"text","conversion_output":true,"text":"In order to perform both assays on a single specimen (Platelia \\({ }^{\\text {TM }}\\) Aspergillus EIA and Fungitell \\({ }^{\\text {® }}\\) beta-D","text_display":"\n\nIn order to perform both assays on a single specimen (Platelia \\({ }^{\\text {TM }}\\) Aspergillus EIA and Fungitell \\({ }^{\\text {® }}\\) beta-D","confidence":0.4902079263702035,"confidence_rate":0.9948841692371782},{"cnt":[[245,1160],[1880,1160],[1880,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1160,"width":1636,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87e2cc9caab34e9da4e703548c3e57e1","type":"text","conversion_output":true,"text":"glucan assay), collect 5 mL of whole blood in a gold top serum-separator tube (provided by MiraVista)","text_display":" glucan assay), collect 5 mL of whole blood in a gold top serum-separator tube (provided by MiraVista)","confidence":1,"confidence_rate":1},{"cnt":[[245,1205],[1880,1205],[1880,1253],[245,1253]],"region":{"top_left_x":244,"top_left_y":1205,"width":1636,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c571eef4f76b4d99899a99bdbc30e31a","type":"text","conversion_output":true,"text":"and label with the site number, COG ID number, and date (labels will be provided with the sample","text_display":" and label with the site number, COG ID number, and date (labels will be provided with the sample","confidence":1,"confidence_rate":1},{"cnt":[[245,1248],[1880,1248],[1880,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1248,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a0a3af933434ab59f435a76f797165f","type":"text","conversion_output":true,"text":"shipping kit). Although the above volume of blood testing will likely represent a small fraction of the","text_display":" shipping kit). Although the above volume of blood testing will likely represent a small fraction of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1293],[1878,1293],[1878,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1293,"width":1634,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6cc436f56ec421f9a87e3ab676ce243","type":"text","conversion_output":true,"text":"blood testing performed during the period of 1 week, it may result in an important increase in certain","text_display":" blood testing performed during the period of 1 week, it may result in an important increase in certain","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[245,1336],[1880,1336],[1880,1386],[245,1386]],"region":{"top_left_x":244,"top_left_y":1336,"width":1636,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cec86b0df02c4bc285f146ff4e73383f","type":"text","conversion_output":true,"text":"patients (i.e., smaller children or anemic children). Therefore, we have set the following maximum limits","text_display":" patients (i.e., smaller children or anemic children). Therefore, we have set the following maximum limits","confidence":1,"confidence_rate":1},{"cnt":[[245,1379],[1880,1379],[1880,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1379,"width":1636,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"328d7093fb6343c4922ec97ebc97533c","type":"text","conversion_output":true,"text":"per kilogram for blood draws related to this ancillary study: 3 mL of blood \\(/ kg\\) body weight in an 8 week","text_display":" per kilogram for blood draws related to this ancillary study: 3 mL of blood \\(/ kg\\) body weight in an 8 week","confidence":0.89013671875,"confidence_rate":0.9990542669065561},{"cnt":[[245,1422],[359,1422],[359,1472],[245,1472]],"region":{"top_left_x":244,"top_left_y":1422,"width":115,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e152d5852c44518aaa5b361b624838e","type":"text","conversion_output":true,"text":"period.","text_display":" period.","confidence":1,"confidence_rate":1},{"cnt":[[243,1504],[711,1504],[711,1566],[243,1566]],"region":{"top_left_x":242,"top_left_y":1503,"width":470,"height":64},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62f0114ca2144e26a24f0f0e972265c6","type":"section_header","conversion_output":false,"children_ids":["6f91dcbef45046138f2a70ed8784fd06"],"text":"","text_display":""},{"cnt":[[247,1508],[707,1508],[707,1560],[247,1560]],"region":{"top_left_x":247,"top_left_y":1508,"width":460,"height":52},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f91dcbef45046138f2a70ed8784fd06","type":"text","conversion_output":true,"parent_id":"62f0114ca2144e26a24f0f0e972265c6","text":"13.1.3 Specimen processing","text_display":"\n\n\\subsection*{13.1.3 Specimen processing}","confidence":1,"confidence_rate":1},{"cnt":[[245,1555],[1240,1555],[1240,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1555,"width":996,"height":50},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dc81bf9163e4a01ac23c80b8f4e2442","type":"text","conversion_output":true,"text":"Each specimen should be processed as follows prior to shipping:","text_display":"\n\nEach specimen should be processed as follows prior to shipping:","confidence":1,"confidence_rate":1},{"cnt":[[370,1601],[1407,1601],[1407,1648],[370,1648]],"region":{"top_left_x":369,"top_left_y":1600,"width":1039,"height":48},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2ea7290a02a4468a196f86a61987400","type":"text","conversion_output":true,"text":"1. Allow the blood to clot for \\(30-60\\) minutes at room temperature.","text_display":"\n1. Allow the blood to clot for \\(30-60\\) minutes at room temperature.","confidence":1,"confidence_rate":1},{"cnt":[[369,1693],[370,1644],[1369,1646],[1369,1695]],"region":{"top_left_x":369,"top_left_y":1643,"width":1000,"height":52},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1598dc5c77c949349b0625bce06569ab","type":"text","conversion_output":true,"text":"2. Centrifuge the specimen for 15 minutes at \\(1,000-1,300 \\times g\\).","text_display":"\n2. Centrifuge the specimen for 15 minutes at \\(1,000-1,300 \\times g\\).","confidence":0.97998046875,"confidence_rate":0.9997152146806867},{"cnt":[[370,1689],[1880,1689],[1880,1738],[370,1738]],"region":{"top_left_x":369,"top_left_y":1688,"width":1511,"height":51},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb0c51a29c4e4e9898fc4ca97a44624f","type":"text","conversion_output":true,"text":"3. Remove the serum from the clot and place it into the provided polypropylene storage tube","text_display":"\n3. Remove the serum from the clot and place it into the provided polypropylene storage tube","confidence":1,"confidence_rate":1},{"cnt":[[432,1732],[724,1732],[724,1777],[432,1777]],"region":{"top_left_x":431,"top_left_y":1731,"width":294,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"578f3a178bd94ea69548dd0a78134d18","type":"text","conversion_output":true,"text":"and label the tube.","text_display":" and label the tube.","confidence":1,"confidence_rate":1},{"cnt":[[370,1775],[1880,1775],[1880,1824],[370,1824]],"region":{"top_left_x":369,"top_left_y":1774,"width":1511,"height":51},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"513415bd3d4a411aaffeb1acb2e5b5b5","type":"text","conversion_output":true,"text":"4. A total minimum volume of 2 mL of serum is required to run the Platelia \\({ }^{\\text {TM }}\\) Aspergillus EIA","text_display":"\n4. A total minimum volume of 2 mL of serum is required to run the Platelia \\({ }^{\\text {TM }}\\) Aspergillus EIA","confidence":0.7620002415496856,"confidence_rate":0.997699189860273},{"cnt":[[432,1818],[988,1818],[988,1869],[432,1869]],"region":{"top_left_x":431,"top_left_y":1817,"width":558,"height":53},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50c1dbef59b1450ca797f3be4b64c7e7","type":"text","conversion_output":true,"text":"and Fungitell \\({ }^{\\circledR}\\) beta-D glucan assay.","text_display":" and Fungitell \\({ }^{\\circledR}\\) beta-D glucan assay.","confidence":0.92041015625,"confidence_rate":0.9983751276881869},{"cnt":[[243,1893],[668,1893],[668,1953],[243,1953]],"region":{"top_left_x":242,"top_left_y":1892,"width":427,"height":61},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3591354589f84c94b9d9951750f5a872","type":"section_header","conversion_output":false,"children_ids":["6e615e9739b8414095e2bd07bed5b44b"],"text":"","text_display":""},{"cnt":[[249,1899],[660,1899],[660,1949],[249,1949]],"region":{"top_left_x":249,"top_left_y":1899,"width":411,"height":50},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e615e9739b8414095e2bd07bed5b44b","type":"text","conversion_output":true,"parent_id":"3591354589f84c94b9d9951750f5a872","text":"13.1.4 Storing specimens","text_display":"\n\n\\subsection*{13.1.4 Storing specimens}","confidence":1,"confidence_rate":1},{"cnt":[[372,1942],[1880,1942],[1880,1992],[372,1992]],"region":{"top_left_x":371,"top_left_y":1942,"width":1509,"height":50},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bd657f4b6cf41da8d9d3f3978672472","type":"text","conversion_output":true,"text":"1. Specimens should be frozen at \\(-70^{\\circ} C\\) the day of collection after following the above","text_display":"\n1. Specimens should be frozen at \\(-70^{\\circ} C\\) the day of collection after following the above","confidence":1,"confidence_rate":1},{"cnt":[[432,1989],[698,1989],[698,2035],[432,2035]],"region":{"top_left_x":431,"top_left_y":1989,"width":268,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cb56c023fc34e7ebb03d110bad56a6a","type":"text","conversion_output":true,"text":"processing steps.","text_display":" processing steps.","confidence":1,"confidence_rate":1},{"cnt":[[370,2032],[1880,2032],[1880,2082],[370,2082]],"region":{"top_left_x":369,"top_left_y":2032,"width":1511,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfed9d7a1c7040f7b55504d0e6815780","type":"text","conversion_output":true,"text":"2. Specimens can be stored at \\(-70^{\\circ} C\\) until shipment. Specimens stored at \\(-70^{\\circ} C\\) may be stored","text_display":"\n2. Specimens can be stored at \\(-70^{\\circ} C\\) until shipment. Specimens stored at \\(-70^{\\circ} C\\) may be stored","confidence":1,"confidence_rate":1},{"cnt":[[430,2075],[625,2075],[625,2125],[430,2125]],"region":{"top_left_x":429,"top_left_y":2075,"width":197,"height":50},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bb7c9085e6a4843a3ae1890d606c44e","type":"text","conversion_output":true,"text":"indefinitely.","text_display":" indefinitely.","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[614,2582],[614,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":371,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29331a433dbc4eebb93ef47b9bd0248c","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1878,2582],[1878,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":130,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8efaf72673d4335b8a7214cbe97f1f8","type":"page_info","conversion_output":false,"text":"Page 39","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"30d0fca4-08d7-48bb-b63f-1324b67d52fd-40","page":40,"lines":[{"cnt":[[262,90],[436,90],[436,122],[262,122]],"region":{"top_left_x":262,"top_left_y":90,"width":175,"height":33},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8d174c415e5b48ee9efe3b3caf0beae6","type":"page_info","conversion_output":false,"text":"CHILDREN'S","text_display":"","confidence":0.98193359375,"confidence_rate":0.9987852985886182},{"cnt":[[262,122],[415,122],[415,157],[262,157]],"region":{"top_left_x":262,"top_left_y":122,"width":153,"height":35},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"13685f7413c64438b17e50ceca5439e0","type":"page_info","conversion_output":false,"text":"ONCOLOGY","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[494,133],[1493,133],[1493,170],[494,170]],"region":{"top_left_x":494,"top_left_y":133,"width":1000,"height":37},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"50821753450e4e9b8b0917f727f93605","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.6124095953133464,"confidence_rate":0.9938893222630198},{"cnt":[[1693,125],[1880,125],[1880,165],[1693,165]],"region":{"top_left_x":1692,"top_left_y":124,"width":188,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0faf61f1c2b74eae8d17736f915fc321","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[363,155],[363,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":102,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"59baa969c9704b0ebbb4c0b269a4e2d7","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,288],[746,288],[746,346],[241,346]],"region":{"top_left_x":240,"top_left_y":287,"width":506,"height":59},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36a67d827dab4340a50747967c5c6e0b","type":"section_header","conversion_output":false,"children_ids":["3f1cde7f0b9e4d12bc4cce79ece58402"],"text":"","text_display":""},{"cnt":[[245,292],[737,292],[737,342],[245,342]],"region":{"top_left_x":244,"top_left_y":292,"width":493,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f1cde7f0b9e4d12bc4cce79ece58402","type":"text","conversion_output":true,"parent_id":"36a67d827dab4340a50747967c5c6e0b","text":"13.1.5 Shipping of specimens:","text_display":"\n\n\\subsection*{13.1.5 Shipping of specimens:}","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a11ab53db0a40feac158d500535a241","type":"text","conversion_output":true,"text":"Each center will use shipping kits provided by MiraVista Diagnostics. These kits contain Styrofoam lined","text_display":"\n\nEach center will use shipping kits provided by MiraVista Diagnostics. These kits contain Styrofoam lined","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1878,382],[1878,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1634,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2899609222e54a949a492b2c0834d343","type":"text","conversion_output":true,"text":"boxes, sealing tape, labels, and a cold pack. The boxes are designed to hold 10 frozen serum specimens.","text_display":" boxes, sealing tape, labels, and a cold pack. The boxes are designed to hold 10 frozen serum specimens.","confidence":0.998046875,"confidence_rate":0.999982387228658},{"cnt":[[245,425],[1725,425],[1725,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1482,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b42ac76fa2f04c2f91f9bb3334d61d6d","type":"text","conversion_output":true,"text":"In order to optimize efficiency, a box should not be sent until 10 specimens have been collected.","text_display":" In order to optimize efficiency, a box should not be sent until 10 specimens have been collected.","confidence":1,"confidence_rate":1},{"cnt":[[370,503],[582,503],[582,552],[370,552]],"region":{"top_left_x":369,"top_left_y":502,"width":214,"height":51},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58c56fcedc264f0798e55e027599e693","type":"text","conversion_output":true,"text":"Requisitions:","text_display":"\n\nRequisitions:","confidence":1,"confidence_rate":1},{"cnt":[[434,546],[1878,546],[1878,595],[434,595]],"region":{"top_left_x":433,"top_left_y":545,"width":1445,"height":51},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67db1b68de0e4e57a2bf1c0a22eae5a0","type":"text","conversion_output":true,"text":"1. Complete an ACCL0933 GM \\& BG Requisition Form for each specimen sent for testing.","text_display":"\n1. Complete an ACCL0933 GM \\& BG Requisition Form for each specimen sent for testing.","confidence":1,"confidence_rate":1},{"cnt":[[494,591],[1302,591],[1302,638],[494,638]],"region":{"top_left_x":494,"top_left_y":590,"width":808,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe5333ac9bf84398a9720b50e1163f04","type":"text","conversion_output":true,"text":"All areas of the requisition form must be completed.","text_display":" All areas of the requisition form must be completed.","confidence":1,"confidence_rate":1},{"cnt":[[370,679],[548,679],[548,724],[370,724]],"region":{"top_left_x":369,"top_left_y":678,"width":179,"height":47},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3d40632067c4bdfa0d4003889f5ff22","type":"text","conversion_output":true,"text":"Packaging:","text_display":"\n\nPackaging:","confidence":1,"confidence_rate":1},{"cnt":[[498,722],[1880,722],[1880,769],[498,769]],"region":{"top_left_x":498,"top_left_y":721,"width":1382,"height":49},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53020c4947b044828a70bdf242d9e94d","type":"text","conversion_output":true,"text":"1. Assure all specimen labels and packaging labels are correct and legible. Please use","text_display":"\n1. Assure all specimen labels and packaging labels are correct and legible. Please use","confidence":1,"confidence_rate":1},{"cnt":[[554,765],[1880,765],[1880,814],[554,814]],"region":{"top_left_x":554,"top_left_y":764,"width":1326,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c068870a02e4edc8f2b754c04ab903a","type":"text","conversion_output":true,"text":"the labels provided in the kits as they are designed to withstand specimen freezing","text_display":" the labels provided in the kits as they are designed to withstand specimen freezing","confidence":1,"confidence_rate":1},{"cnt":[[554,812],[1880,812],[1880,857],[554,857]],"region":{"top_left_x":554,"top_left_y":812,"width":1326,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3346421f635f4dc28f98bce9faad20aa","type":"text","conversion_output":true,"text":"and thawing without disruption of the written patient identification information. A","text_display":" and thawing without disruption of the written patient identification information. A","confidence":1,"confidence_rate":1},{"cnt":[[554,853],[1480,853],[1480,900],[554,900]],"region":{"top_left_x":554,"top_left_y":852,"width":927,"height":49},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5d31419c27346789bb2b602aabc5032","type":"text","conversion_output":true,"text":"Sharpie marker is most effective for writing on these labels.","text_display":" Sharpie marker is most effective for writing on these labels.","confidence":1,"confidence_rate":1},{"cnt":[[494,898],[1880,898],[1880,947],[494,947]],"region":{"top_left_x":494,"top_left_y":898,"width":1386,"height":50},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dc01de5cfd24091ad9e5c24715835c7","type":"text","conversion_output":true,"text":"2. Place the labeled vials containing the patient serum into a biohazard plastic bag along","text_display":"\n2. Place the labeled vials containing the patient serum into a biohazard plastic bag along","confidence":1,"confidence_rate":1},{"cnt":[[554,941],[1880,941],[1880,990],[554,990]],"region":{"top_left_x":554,"top_left_y":941,"width":1326,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d41df476ec614137a26e737579564383","type":"text","conversion_output":true,"text":"with absorbent material such as gauze or paper towel and seal. Use the biohazard","text_display":" with absorbent material such as gauze or paper towel and seal. 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Ship specimens in the boxes provided along with the cold pack that should be frozen.","confidence":1,"confidence_rate":1},{"cnt":[[494,1074],[1639,1074],[1639,1119],[494,1119]],"region":{"top_left_x":494,"top_left_y":1074,"width":1146,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7d62879ceb845cda63127a0f2f58a8a","type":"text","conversion_output":true,"text":"4. Open the box and remove the Styrofoam liner lid and the sealing tape.","text_display":"\n4. Open the box and remove the Styrofoam liner lid and the sealing tape.","confidence":1,"confidence_rate":1},{"cnt":[[494,1117],[1880,1117],[1880,1164],[494,1164]],"region":{"top_left_x":494,"top_left_y":1117,"width":1386,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b20b5c4dd1204f6c920d6474c04f298f","type":"text","conversion_output":true,"text":"5. Place the frozen cold pack into the liner. 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Wet the sealing tape provided in the kit and seal the cardboard box.","confidence":1,"confidence_rate":1},{"cnt":[[498,1470],[1880,1470],[1880,1515],[498,1515]],"region":{"top_left_x":498,"top_left_y":1469,"width":1382,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2e42f0240ff440a8d7ebcc19f2dbea5","type":"text","conversion_output":true,"text":"10. If the specimen tube labels and requisition forms do not match when received at","text_display":"\n10. If the specimen tube labels and requisition forms do not match when received at","confidence":0.9834063053131104,"confidence_rate":0.9998098713463265},{"cnt":[[554,1512],[1800,1512],[1800,1562],[554,1562]],"region":{"top_left_x":554,"top_left_y":1512,"width":1247,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"378d5aeed562453b87642a15dbff5b9a","type":"text","conversion_output":true,"text":"MiraVista Diagnostics, a call will be made to the study site on the day of receipt.","text_display":" MiraVista Diagnostics, a call will be made to the study site on the day of receipt.","confidence":1,"confidence_rate":1},{"cnt":[[370,1601],[715,1601],[715,1648],[370,1648]],"region":{"top_left_x":369,"top_left_y":1600,"width":347,"height":48},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a264ef1ddc2c4d02aad1eeb2b839b949","type":"text","conversion_output":true,"text":"Shipping Instructions:","text_display":"\n\nShipping Instructions:","confidence":1,"confidence_rate":1},{"cnt":[[434,1646],[1111,1646],[1111,1691],[434,1691]],"region":{"top_left_x":433,"top_left_y":1645,"width":678,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1aa1ddc23d6f448b9f9e95dac64a4aee","type":"text","conversion_output":true,"text":"1. Ship packages to the following address:","text_display":"\n1. Ship packages to the following address:","confidence":1,"confidence_rate":1},{"cnt":[[804,1704],[1179,1704],[1179,1884],[804,1884]],"region":{"top_left_x":803,"top_left_y":1703,"width":377,"height":182},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb5f2fa346a14e53a64d70ddd3d81844","type":"diagram","conversion_output":false,"children_ids":["ca6c40e795e841eab379d472d7388ad2","491362b4567e4966bb41b00460f90bd0","e4dcee4e6c7748f8a7f5c0c1b9225184","ded313156dbb42ab9302a6223e5e8204"],"text":"","text_display":"","subtype":"algorithm"},{"cnt":[[804,1710],[1162,1710],[1162,1755],[804,1755]],"region":{"top_left_x":803,"top_left_y":1710,"width":360,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca6c40e795e841eab379d472d7388ad2","type":"code","conversion_output":true,"parent_id":"eb5f2fa346a14e53a64d70ddd3d81844","text":"MiraVista Diagnostics","text_display":"\n```\nMiraVista Diagnostics","confidence":0.99951171875,"confidence_rate":0.9999796501863057},{"cnt":[[804,1753],[1119,1753],[1119,1794],[804,1794]],"region":{"top_left_x":803,"top_left_y":1753,"width":317,"height":41},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"491362b4567e4966bb41b00460f90bd0","type":"code","conversion_output":true,"parent_id":"eb5f2fa346a14e53a64d70ddd3d81844","text":"4705 Decatur Blvd.","text_display":"\n4705 Decatur Blvd.","confidence":1,"confidence_rate":1},{"cnt":[[804,1796],[1175,1796],[1175,1841],[804,1841]],"region":{"top_left_x":803,"top_left_y":1796,"width":373,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4dcee4e6c7748f8a7f5c0c1b9225184","type":"code","conversion_output":true,"parent_id":"eb5f2fa346a14e53a64d70ddd3d81844","text":"Indianapolis, IN 46241","text_display":"\nIndianapolis, IN 46241","confidence":1,"confidence_rate":1},{"cnt":[[804,1841],[1029,1841],[1029,1880],[804,1880]],"region":{"top_left_x":803,"top_left_y":1841,"width":227,"height":39},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ded313156dbb42ab9302a6223e5e8204","type":"code","conversion_output":true,"parent_id":"eb5f2fa346a14e53a64d70ddd3d81844","text":"317-856-2681","text_display":"\n317-856-2681\n```\n","confidence":1,"confidence_rate":1},{"cnt":[[430,1927],[1861,1927],[1861,1974],[430,1974]],"region":{"top_left_x":429,"top_left_y":1927,"width":1432,"height":48},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be2d43d242f0418eb92e4ee0a0271eb5","type":"text","conversion_output":true,"text":"2. Use the FedEx website (www.fedex.com) to learn the current guidelines for the shipping","text_display":"\n2. Use the FedEx website (www.fedex.com) to learn the current guidelines for the shipping","confidence":1,"confidence_rate":1},{"cnt":[[494,1972],[1317,1972],[1317,2017],[494,2017]],"region":{"top_left_x":494,"top_left_y":1972,"width":823,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f2e723fb7ad4ab2af3c7f22d2f89100","type":"text","conversion_output":true,"text":"of human body fluids and generating shipping labels.","text_display":" of human body fluids and generating shipping labels.","confidence":1,"confidence_rate":1},{"cnt":[[432,2015],[1863,2015],[1863,2065],[432,2065]],"region":{"top_left_x":431,"top_left_y":2015,"width":1432,"height":50},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"906b163b03e9407f8d1f77ebf4511ce6","type":"text","conversion_output":true,"text":"3. 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The specimen has been shipped under unacceptable time and/or temperature","confidence":1,"confidence_rate":1},{"cnt":[[559,602],[733,602],[733,642],[559,642]],"region":{"top_left_x":558,"top_left_y":601,"width":175,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95cc4648f8094b2ea367c2c480303e97","type":"text","conversion_output":true,"text":"conditions.","text_display":" conditions.","confidence":1,"confidence_rate":1},{"cnt":[[494,649],[1687,649],[1687,694],[494,694]],"region":{"top_left_x":494,"top_left_y":648,"width":1193,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a4c50535f184cebbfa2762edf873ca5","type":"text","conversion_output":true,"text":"c. The specimen volume is less than needed to complete the testing process.","text_display":"\nc. The specimen volume is less than needed to complete the testing process.","confidence":1,"confidence_rate":1},{"cnt":[[494,692],[1326,692],[1326,737],[494,737]],"region":{"top_left_x":494,"top_left_y":691,"width":832,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38d5920253c54d9bbb344c0920d60d4e","type":"text","conversion_output":true,"text":"d. The specimen cannot be pipetted due to viscosity.","text_display":"\nd. The specimen cannot be pipetted due to viscosity.","confidence":1,"confidence_rate":1},{"cnt":[[494,733],[1366,733],[1366,780],[494,780]],"region":{"top_left_x":494,"top_left_y":732,"width":873,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"981349f1581746c38527086242ce48bd","type":"text","conversion_output":true,"text":"e. The specimen is hemolyzed or icteric for Fungitell \\({ }^{\\circledR}\\).","text_display":"\ne. The specimen is hemolyzed or icteric for Fungitell \\({ }^{\\circledR}\\).","confidence":0.92333984375,"confidence_rate":0.9988928644730904},{"cnt":[[494,778],[1562,778],[1562,823],[494,823]],"region":{"top_left_x":494,"top_left_y":777,"width":1068,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e24846a892fe452598df238f4e1bf07f","type":"text","conversion_output":true,"text":"f. The specimen is of a type other than serum separated off the clot.","text_display":"\nf. The specimen is of a type other than serum separated off the clot.","confidence":1,"confidence_rate":1},{"cnt":[[370,821],[1396,821],[1396,866],[370,866]],"region":{"top_left_x":369,"top_left_y":820,"width":1028,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6fa58b4e7a84586b224610ea9ef2d29","type":"text","conversion_output":true,"text":"3. Platelia \\({ }^{ TM }\\) Aspergillus EIA results are reported as a GM index.","text_display":"\n3. Platelia \\({ }^{ TM }\\) Aspergillus EIA results are reported as a GM index.","confidence":0.9941470623016357,"confidence_rate":0.9999301199028297},{"cnt":[[370,864],[1377,864],[1377,913],[370,913]],"region":{"top_left_x":369,"top_left_y":863,"width":1009,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6439f4f1b5804918a4bdb38bde1644b0","type":"text","conversion_output":true,"text":"4. Fungitell \\({ }^{\\circledR}\\) beta-D glucan assay results are reported as \\(pg / mL\\).","text_display":"\n4. Fungitell \\({ }^{\\circledR}\\) beta-D glucan assay results are reported as \\(pg / mL\\).","confidence":0.5561152743175626,"confidence_rate":0.9935014334097216},{"cnt":[[245,954],[862,954],[862,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":953,"width":618,"height":55},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"711f1f9f3ac744359414f65a96f8685e","type":"section_header","conversion_output":false,"children_ids":["2d64f4c497994a66bf73b07751ca6704"],"text":"","text_display":""},{"cnt":[[249,958],[855,958],[855,1001],[249,1001]],"region":{"top_left_x":249,"top_left_y":958,"width":607,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d64f4c497994a66bf73b07751ca6704","type":"text","conversion_output":true,"parent_id":"711f1f9f3ac744359414f65a96f8685e","text":"13.1.7 MiraVista Contact Information","text_display":"\n\n\\subsection*{13.1.7 MiraVista Contact Information}","confidence":0.97900390625,"confidence_rate":0.9994825815554398},{"cnt":[[245,1021],[1330,1021],[1330,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1020,"width":1086,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ad229e2aac341e8b350df2451c5843f","type":"text","conversion_output":true,"text":"Technical Assistance: Patti Connolly 317-856-2681 x451","text_display":"\n\nTechnical Assistance: Patti Connolly 317-856-2681 x451","confidence":0.9990236759185791,"confidence_rate":0.9999834441879605},{"cnt":[[245,1096],[1330,1096],[1330,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1095,"width":1086,"height":51},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22c806b22bd34dd2a03673769630868d","type":"text","conversion_output":true,"text":"Medical Director: Joseph Wheat, M.D. 317-856-2681 x452","text_display":"\nMedical Director: Joseph Wheat, M.D. 317-856-2681 x452","confidence":0.9956114260718323,"confidence_rate":0.9999254564736623},{"cnt":[[245,1182],[1038,1182],[1038,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1181,"width":794,"height":55},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a715e655dd4745dda3483004e9c22d21","type":"section_header","conversion_output":false,"children_ids":["3feb33e400e54961a2e305439ff36662"],"text":"","text_display":""},{"cnt":[[249,1186],[1033,1186],[1033,1231],[249,1231]],"region":{"top_left_x":249,"top_left_y":1185,"width":785,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3feb33e400e54961a2e305439ff36662","type":"text","conversion_output":true,"parent_id":"a715e655dd4745dda3483004e9c22d21","text":"13.1.8 Galactomannan and Beta-D glucan Assays","text_display":"\n\n\\subsection*{13.1.8 Galactomannan and Beta-D glucan Assays}","confidence":1,"confidence_rate":1},{"cnt":[[245,1229],[1880,1229],[1880,1276],[245,1276]],"region":{"top_left_x":244,"top_left_y":1228,"width":1636,"height":49},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4883a48a93b7462493cad57a9ea3be89","type":"text","conversion_output":true,"text":"Testing will be performed by technicians blinded to each patient's clinical information. Test results will","text_display":"\n\nTesting will be performed by technicians blinded to each patient's clinical information. Test results will","confidence":1,"confidence_rate":1},{"cnt":[[245,1276],[1880,1276],[1880,1319],[245,1319]],"region":{"top_left_x":244,"top_left_y":1276,"width":1636,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a5bcc09d778434ab51a05103efe6e45","type":"text","conversion_output":true,"text":"not be made available to treating physicians since the utility of these tests is not yet established in","text_display":" not be made available to treating physicians since the utility of these tests is not yet established in","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,1319],[1880,1319],[1880,1364],[245,1364]],"region":{"top_left_x":244,"top_left_y":1319,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c56426320fb43c0b92ae9fbef9fc55d","type":"text","conversion_output":true,"text":"children and because we will not be conducting testing in real time. Thus, results will not be utilized","text_display":" children and because we will not be conducting testing in real time. Thus, results will not be utilized","confidence":1,"confidence_rate":1},{"cnt":[[245,1362],[715,1362],[715,1407],[245,1407]],"region":{"top_left_x":244,"top_left_y":1362,"width":472,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2a4fc7030134500ae2753735e347f08","type":"text","conversion_output":true,"text":"for clinical decision-making.","text_display":" for clinical decision-making.","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1880,1439],[1880,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac455ca560fa49f0953c6c95a7e8b521","type":"text","conversion_output":true,"text":"To our knowledge BG testing is not routinely performed at many pediatric centers but may be performed","text_display":"\n\nTo our knowledge BG testing is not routinely performed at many pediatric centers but may be performed","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1880,1487],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48f8eedb7a9146f998d414de920200ce","type":"text","conversion_output":true,"text":"at some of the COG sites while GM testing is currently performed at a number of pediatric centers.","text_display":" at some of the COG sites while GM testing is currently performed at a number of pediatric centers.","confidence":0.9985356330871582,"confidence_rate":0.9999857725269791},{"cnt":[[245,1530],[1880,1530],[1880,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":1636,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bdd355ebc3e4bc2892a490ec5b762fe","type":"text","conversion_output":true,"text":"Regardless of the number of institutions offering such testing options, we anticipate that such testing will","text_display":" Regardless of the number of institutions offering such testing options, we anticipate that such testing will","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1880,1573],[1880,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1572,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ee61556132a43bdb2acfd7a155f43a7","type":"text","conversion_output":true,"text":"be ordered by a subset of treating physicians. The local BG and GM results will not be included in our","text_display":" be ordered by a subset of treating physicians. The local BG and GM results will not be included in our","confidence":1,"confidence_rate":1},{"cnt":[[245,1618],[1880,1618],[1880,1663],[245,1663]],"region":{"top_left_x":244,"top_left_y":1617,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bef03b381d4421fbabbbda4ba995cdc","type":"text","conversion_output":true,"text":"final analysis of the 2 biomarker assays' operating characteristics. However, these results may effect a","text_display":" final analysis of the 2 biomarker assays' operating characteristics. However, these results may effect a","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[1880,1663],[1880,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1662,"width":1636,"height":47},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2620da1a5a814c538e08c3a0d887f1e3","type":"text","conversion_output":true,"text":"change from fungal prophylaxis to preemptive or empiric therapy and may encourage or discourage more","text_display":" change from fungal prophylaxis to preemptive or empiric therapy and may encourage or discourage more","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1880,1706],[1880,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1705,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5adf9d8a9137447a867e8a16e4cb139f","type":"text","conversion_output":true,"text":"comprehensive efforts to diagnose a proven or probable IFI in any given patient. This in turn may falsely","text_display":" comprehensive efforts to diagnose a proven or probable IFI in any given patient. This in turn may falsely","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1880,1749],[1880,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c097f024b5143e3b74f6571c3dc7151","type":"text","conversion_output":true,"text":"influence our evaluation of the 2 biomarker assays' operating characteristics. For each patient we will","text_display":" influence our evaluation of the 2 biomarker assays' operating characteristics. For each patient we will","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,1792],[1880,1792],[1880,1839],[245,1839]],"region":{"top_left_x":244,"top_left_y":1791,"width":1636,"height":49},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"980fccdec9884ab19985eab6623e0c97","type":"text","conversion_output":true,"text":"identify whether local BG or GM testing has been performed and, via a sensitivity analysis, explore","text_display":" identify whether local BG or GM testing has been performed and, via a sensitivity analysis, explore","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1880,1835],[1880,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1636,"height":51},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"236ccf334491403d89eddda13497244b","type":"text","conversion_output":true,"text":"whether such a practice influences the operating characteristics. The plans for this sensitivity analysis are","text_display":" whether such a practice influences the operating characteristics. The plans for this sensitivity analysis are","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1003,1882],[1003,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1882,"width":760,"height":41},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf7f166fce5d452097774b0eaf9df7b7","type":"text","conversion_output":true,"text":"described in more detail in Section 13.8.4 below.","text_display":" described in more detail in Section 13.8.4 below.","confidence":1,"confidence_rate":1},{"cnt":[[245,1959],[1880,1959],[1880,2007],[245,2007]],"region":{"top_left_x":244,"top_left_y":1959,"width":1636,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc99567d863b40b69c251e6367c3f513","type":"text","conversion_output":true,"text":"The Platelia Aspergillus EIA study is reported as a GM index. We will use the FDA-approved threshold","text_display":"\n\nThe Platelia Aspergillus EIA study is reported as a GM index. We will use the FDA-approved threshold","confidence":1,"confidence_rate":1},{"cnt":[[245,2004],[1880,2004],[1880,2052],[245,2052]],"region":{"top_left_x":244,"top_left_y":2004,"width":1636,"height":48},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94f2391fccc14f4dbf64a5925b156bc0","type":"text","conversion_output":true,"text":"of \\(\\geq 0.5\\) GM index on a single test sample as our criteria for a positive test result. The Fungitell Assay is","text_display":" of \\(\\geq 0.5\\) GM index on a single test sample as our criteria for a positive test result. The Fungitell Assay is","confidence":0.83544921875,"confidence_rate":0.9984378673816036},{"cnt":[[245,2050],[1880,2050],[1880,2095],[245,2095]],"region":{"top_left_x":244,"top_left_y":2049,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"530e8a648e674f13bdadffe69d90c3b9","type":"text","conversion_output":true,"text":"reported in pg per mL of patient's serum. The manufacturer recommendation for a single positive","text_display":" reported in pg per mL of patient's serum. The manufacturer recommendation for a single positive","confidence":0.55322265625,"confidence_rate":0.9940975411093397},{"cnt":[[245,2093],[1377,2093],[1377,2138],[245,2138]],"region":{"top_left_x":244,"top_left_y":2092,"width":1134,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ccf78e41a51431e8fbb9fef7be0b748","type":"text","conversion_output":true,"text":"Fungitell assay result of \\(\\geq 80 pg / mL\\) will be used to define a positive test.","text_display":" Fungitell assay result of \\(\\geq 80 pg / mL\\) will be used to define a positive test.","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[612,2582],[612,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":369,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e435a3acca9461c9fff8dc83b3e1f29","type":"page_info","conversion_output":false,"text":"Version Date: 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Prophylaxis: Initiation of antifungal therapy in asymptomatic patients without any evidence","text_display":"\n1. Prophylaxis: Initiation of antifungal therapy in asymptomatic patients without any evidence","confidence":1,"confidence_rate":1},{"cnt":[[432,494],[1880,494],[1880,541],[432,541]],"region":{"top_left_x":431,"top_left_y":494,"width":1449,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec135e0e767c426fa447b8e2ac9cc62d","type":"text","conversion_output":true,"text":"of IFI, during periods of high risk such as during prolonged neutropenia resulting from","text_display":" of IFI, during periods of high risk such as during prolonged neutropenia resulting from","confidence":1,"confidence_rate":1},{"cnt":[[432,541],[1081,541],[1081,587],[432,587]],"region":{"top_left_x":431,"top_left_y":541,"width":650,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e593a0dc3274906a91c70e82d985db0","type":"text","conversion_output":true,"text":"chemotherapy or bone marrow transplant.","text_display":" chemotherapy or bone marrow transplant.","confidence":1,"confidence_rate":1},{"cnt":[[370,580],[1880,580],[1880,629],[370,629]],"region":{"top_left_x":369,"top_left_y":580,"width":1511,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"515a574d987f4a71b22a85fec90b0a85","type":"text","conversion_output":true,"text":"2. Empirical antifungal therapy: Initiation or modification of antifungal therapy after persistence","text_display":"\n2. Empirical antifungal therapy: Initiation or modification of antifungal therapy after persistence","confidence":1,"confidence_rate":1},{"cnt":[[432,627],[1489,627],[1489,672],[432,672]],"region":{"top_left_x":431,"top_left_y":627,"width":1058,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bda41caa02894de4b370094f41689d71","type":"text","conversion_output":true,"text":"of fever in the setting of neutropenia and broad-spectrum antibiotics.","text_display":" of fever in the setting of neutropenia and broad-spectrum antibiotics.","confidence":1,"confidence_rate":1},{"cnt":[[370,670],[1880,670],[1880,715],[370,715]],"region":{"top_left_x":369,"top_left_y":670,"width":1511,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf4850b730b045d99087cc91daf9b6a6","type":"text","conversion_output":true,"text":"3. Preemptive therapy: Use of radiographic and/or specific biomarkers to identify and treat","text_display":"\n3. Preemptive therapy: Use of radiographic and/or specific biomarkers to identify and treat","confidence":1,"confidence_rate":1},{"cnt":[[432,713],[1184,713],[1184,761],[432,761]],"region":{"top_left_x":431,"top_left_y":713,"width":753,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bb3e79521af4a19b9824bf1620b1c36","type":"text","conversion_output":true,"text":"suspected IFI prior to overt clinical presentation.","text_display":" suspected IFI prior to overt clinical presentation.","confidence":1,"confidence_rate":1},{"cnt":[[370,758],[1878,758],[1878,806],[370,806]],"region":{"top_left_x":369,"top_left_y":758,"width":1509,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b131ee66ed8c4f7c811d573aba20b0d6","type":"text","conversion_output":true,"text":"4. Therapy for proven, probable or presumed IFI: Therapy initiated for the treatment of proven","text_display":"\n4. Therapy for proven, probable or presumed IFI: Therapy initiated for the treatment of proven","confidence":1,"confidence_rate":1},{"cnt":[[432,804],[1777,804],[1777,849],[432,849]],"region":{"top_left_x":431,"top_left_y":803,"width":1346,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3cb2f0b11c07471799956255dfc8fd2d","type":"text","conversion_output":true,"text":"or probable IFI based on EORTC/MSG criteria or based on clinical presumption of IFI.","text_display":" or probable IFI based on EORTC/MSG criteria or based on clinical presumption of IFI.","confidence":1,"confidence_rate":1},{"cnt":[[245,881],[1880,881],[1880,930],[245,930]],"region":{"top_left_x":244,"top_left_y":880,"width":1636,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f17ac0d4eb34cd49409b52d3aa6384a","type":"text","conversion_output":true,"text":"The significant morbidity and mortality associated with IFI among patients with AML has led many","text_display":"\n\nThe significant morbidity and mortality associated with IFI among patients with AML has led many","confidence":1,"confidence_rate":1},{"cnt":[[245,924],[1880,924],[1880,973],[245,973]],"region":{"top_left_x":244,"top_left_y":923,"width":1636,"height":51},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d75b607719f4487390267f3ab05be205","type":"text","conversion_output":true,"text":"clinicians to adopt a strategy that includes antifungal prophylaxis during periods of neutropenia. \\({ }^{19}\\)","text_display":" clinicians to adopt a strategy that includes antifungal prophylaxis during periods of neutropenia. \\({ }^{19}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,971],[1880,971],[1880,1016],[245,1016]],"region":{"top_left_x":244,"top_left_y":971,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae11cd7d1ba245c58a0345c01c03fbca","type":"text","conversion_output":true,"text":"Retrospective evaluation of neutropenic children receiving fungal prophylaxis with fluconazole or","text_display":" Retrospective evaluation of neutropenic children receiving fungal prophylaxis with fluconazole or","confidence":1,"confidence_rate":1},{"cnt":[[245,1012],[1880,1012],[1880,1059],[245,1059]],"region":{"top_left_x":244,"top_left_y":1011,"width":1636,"height":49},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57c56e69a5d1461d90417e4b5d09f6b3","type":"text","conversion_output":true,"text":"micafungin suggested a reduction in the risk for IFI. \\({ }^{57,58}\\) The ideal antifungal agent for such prophylaxis in","text_display":" micafungin suggested a reduction in the risk for IFI. \\({ }^{57,58}\\) The ideal antifungal agent for such prophylaxis in","confidence":0.9990234375,"confidence_rate":0.9999921837133647},{"cnt":[[245,1057],[1880,1057],[1880,1104],[245,1104]],"region":{"top_left_x":244,"top_left_y":1057,"width":1636,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"192e50bb20c74ca89bb643ffcee6b85e","type":"text","conversion_output":true,"text":"children is not known and will be addressed in the primary aim of this study. Regardless of the specific","text_display":" children is not known and will be addressed in the primary aim of this study. Regardless of the specific","confidence":1,"confidence_rate":1},{"cnt":[[245,1102],[1878,1102],[1878,1147],[245,1147]],"region":{"top_left_x":244,"top_left_y":1102,"width":1634,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"947f0a6765ea44de92d5a7dfc4086bea","type":"text","conversion_output":true,"text":"antifungal agent, it is likely that prophylaxis will be successful and be integrated as the standard of care","text_display":" antifungal agent, it is likely that prophylaxis will be successful and be integrated as the standard of care","confidence":1,"confidence_rate":1},{"cnt":[[245,1145],[1878,1145],[1878,1192],[245,1192]],"region":{"top_left_x":244,"top_left_y":1145,"width":1634,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf3b52bbe72741e8a532ae162e5b10ac","type":"text","conversion_output":true,"text":"for all future pediatric AML therapy. Despite a reduction in IFI, prophylaxis will not eliminate all such","text_display":" for all future pediatric AML therapy. Despite a reduction in IFI, prophylaxis will not eliminate all such","confidence":1,"confidence_rate":1},{"cnt":[[245,1190],[1878,1190],[1878,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1190,"width":1634,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6b23018215347f5b51749c05dbe8265","type":"text","conversion_output":true,"text":"infections. In patients with breakthrough infections on prophylactic therapy, early suspicion for IFI and","text_display":" infections. In patients with breakthrough infections on prophylactic therapy, early suspicion for IFI and","confidence":1,"confidence_rate":1},{"cnt":[[245,1233],[1618,1233],[1618,1278],[245,1278]],"region":{"top_left_x":244,"top_left_y":1233,"width":1374,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee8856e3b38941758c393462b4f7240e","type":"text","conversion_output":true,"text":"modification of antifungal therapy will still be paramount to improving patient outcomes.","text_display":" modification of antifungal therapy will still be paramount to improving patient outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[245,1313],[1880,1313],[1880,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1312,"width":1636,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"778c721bdeb644aca5303edeace94147","type":"text","conversion_output":true,"text":"Unfortunately, the current approach for risk stratification of IFI (persistence of fever for \\(\\geq 5\\) days on","text_display":"\n\nUnfortunately, the current approach for risk stratification of IFI (persistence of fever for \\(\\geq 5\\) days on","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,1354],[1880,1354],[1880,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1353,"width":1636,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba65050f076b41cbbba6f7ba2c51e13b","type":"text","conversion_output":true,"text":"broad spectrum antibiotics) may be less than ideal in populations at high risk for IFI. \\({ }^{56}\\) The clinical","text_display":" broad spectrum antibiotics) may be less than ideal in populations at high risk for IFI. \\({ }^{56}\\) The clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1880,1401],[1880,1448],[245,1448]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":49},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e246854e18d541c2bf3e4894e2f90114","type":"text","conversion_output":true,"text":"presentation at the start of an IFI can range from completely asymptomatic, to fever without localizing","text_display":" presentation at the start of an IFI can range from completely asymptomatic, to fever without localizing","confidence":1,"confidence_rate":1},{"cnt":[[245,1446],[1880,1446],[1880,1491],[245,1491]],"region":{"top_left_x":244,"top_left_y":1445,"width":1636,"height":47},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1cd765bcd824ca090177f13e51dee87","type":"text","conversion_output":true,"text":"signs or symptoms, to clinical sepsis. This is illustrated by a randomized trial of empiric caspofungin vs.","text_display":" signs or symptoms, to clinical sepsis. This is illustrated by a randomized trial of empiric caspofungin vs.","confidence":1,"confidence_rate":1},{"cnt":[[245,1489],[1876,1489],[1876,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1488,"width":1632,"height":49},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14a9cfdf3d674e7b8ab541f163d07f12","type":"text","conversion_output":true,"text":"liposomal amphotericin B. Patients were excluded from this study if they had a current documented IFI.","text_display":" liposomal amphotericin B. Patients were excluded from this study if they had a current documented IFI.","confidence":1,"confidence_rate":1},{"cnt":[[245,1534],[1880,1534],[1880,1579],[245,1579]],"region":{"top_left_x":244,"top_left_y":1533,"width":1636,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dae4d01b059847f88424971fdb83c3d9","type":"text","conversion_output":true,"text":"Despite this, 4.9\\% of subjects were ultimately identified as having proven or probable IFI at baseline prior","text_display":" Despite this, 4.9\\% of subjects were ultimately identified as having proven or probable IFI at baseline prior","confidence":0.6298828125,"confidence_rate":0.9959178988654507},{"cnt":[[245,1577],[1880,1577],[1880,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1576,"width":1636,"height":47},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31562a91b01a40c589ed915b2c576345","type":"text","conversion_output":true,"text":"to initiating the antifungal treatment. \\({ }^{26}\\) Therefore, relying on traditional methods to guide empiric","text_display":" to initiating the antifungal treatment. \\({ }^{26}\\) Therefore, relying on traditional methods to guide empiric","confidence":1,"confidence_rate":1},{"cnt":[[245,1620],[1880,1620],[1880,1667],[245,1667]],"region":{"top_left_x":244,"top_left_y":1619,"width":1636,"height":49},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44babab36c9044fea711b0cbe5e968a0","type":"text","conversion_output":true,"text":"antifungal modifications would result in over-treating some patients with low likelihood of IFI and a","text_display":" antifungal modifications would result in over-treating some patients with low likelihood of IFI and a","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[1880,1663],[1880,1712],[245,1712]],"region":{"top_left_x":244,"top_left_y":1662,"width":1636,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"519b61e9213a45d5b7f2d5c2149bdd59","type":"text","conversion_output":true,"text":"failure to modify therapy in other patients that have an underlying IFI. A preemptive therapeutic approach","text_display":" failure to modify therapy in other patients that have an underlying IFI. A preemptive therapeutic approach","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,1710],[1880,1710],[1880,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1710,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"487be7838f904af28cbed3e5171d0b20","type":"text","conversion_output":true,"text":"that utilizes screening diagnostic studies to identify patients likely to have an IFI at the earliest possible","text_display":" that utilizes screening diagnostic studies to identify patients likely to have an IFI at the earliest possible","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[907,1753],[907,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1753,"width":663,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e199385474c34fff81ad06e8bde62975","type":"text","conversion_output":true,"text":"point may be more rational and successful.","text_display":" point may be more rational and successful.","confidence":1,"confidence_rate":1},{"cnt":[[243,1826],[1549,1826],[1549,1884],[243,1884]],"region":{"top_left_x":242,"top_left_y":1826,"width":1308,"height":59},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"438e64d6e1e04e1185033816c82e7b32","type":"section_header","conversion_output":false,"children_ids":["9576cc6e81b1458b9b306ccdd4036fe8"],"text":"","text_display":""},{"cnt":[[249,1830],[1545,1830],[1545,1880],[249,1880]],"region":{"top_left_x":249,"top_left_y":1830,"width":1296,"height":50},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9576cc6e81b1458b9b306ccdd4036fe8","type":"text","conversion_output":true,"parent_id":"438e64d6e1e04e1185033816c82e7b32","text":"13.2.2 Traditional diagnostic studies to identify patients with suspected IFI","text_display":"\n\n\\subsection*{13.2.2 Traditional diagnostic studies to identify patients with suspected IFI}","confidence":1,"confidence_rate":1},{"cnt":[[245,1876],[1880,1876],[1880,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1875,"width":1636,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1cff27e3d7c422cb2c375770e975fba","type":"text","conversion_output":true,"text":"Traditional diagnostic modalities for IFI are limited to radiologic imaging and blood or tissue culture","text_display":"\n\nTraditional diagnostic modalities for IFI are limited to radiologic imaging and blood or tissue culture","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1880,1921],[1880,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1636,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f166126d7324aba8b71dec9a230e17d","type":"text","conversion_output":true,"text":"techniques. Radiologic studies may show visceral involvement but an invasive biopsy procedure is","text_display":" techniques. Radiologic studies may show visceral involvement but an invasive biopsy procedure is","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1880,1964],[1880,2011],[245,2011]],"region":{"top_left_x":244,"top_left_y":1963,"width":1636,"height":48},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a8bab2b2fd640299b918bcca968ae73","type":"text","conversion_output":true,"text":"necessary to differentiate between a fungal or non-fungal infectious process. Although blood cultures may","text_display":" necessary to differentiate between a fungal or non-fungal infectious process. 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Galactomannan and Beta-D Glucan Assays","text_display":"\n\n\\subsection*{13.2.3 Galactomannan and Beta-D Glucan Assays}","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1884,296],[1884,346],[245,346]],"region":{"top_left_x":244,"top_left_y":296,"width":1641,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afb3c9d88ab04a249ba362cbb655aa5a","type":"text","conversion_output":true,"text":"Alternative non-invasive approaches involve serial evaluation of a patient's serum for the presence of","text_display":"\n\nAlternative non-invasive approaches involve serial evaluation of a patient's serum for the presence of","confidence":1,"confidence_rate":1},{"cnt":[[245,344],[1880,344],[1880,389],[245,389]],"region":{"top_left_x":244,"top_left_y":343,"width":1636,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc8197467d3541079de8cc1151f51acc","type":"text","conversion_output":true,"text":"galactomannan (GM) or beta-D glucan (BG). The former is present in Aspergillus spp. while the latter is","text_display":" galactomannan (GM) or beta-D glucan (BG). The former is present in Aspergillus spp. while the latter is","confidence":1,"confidence_rate":1},{"cnt":[[245,385],[1880,385],[1880,436],[245,436]],"region":{"top_left_x":244,"top_left_y":384,"width":1636,"height":53},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59f83d0afa5b4a678d7061d4825ff3f5","type":"text","conversion_output":true,"text":"present in a vast majority of pathogenic fungi. \\({ }^{59,60}\\) Two validated FDA approved antigen detection assays,","text_display":" present in a vast majority of pathogenic fungi. \\({ }^{59,60}\\) Two validated FDA approved antigen detection assays,","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1880,430],[1880,477],[245,477]],"region":{"top_left_x":244,"top_left_y":429,"width":1636,"height":48},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a399bbebe904be98032528a08fb29c6","type":"text","conversion_output":true,"text":"The Platelia Aspergillus EIA and the Fungitell Assay, currently exist for the detection of GM and BG,","text_display":" The Platelia Aspergillus EIA and the Fungitell Assay, currently exist for the detection of GM and BG,","confidence":1,"confidence_rate":1},{"cnt":[[245,475],[449,475],[449,522],[245,522]],"region":{"top_left_x":244,"top_left_y":474,"width":206,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0d97fb628c84d44a677f2d4d255dfcb","type":"text","conversion_output":true,"text":"respectively.","text_display":" respectively.","confidence":1,"confidence_rate":1},{"cnt":[[241,546],[1420,546],[1420,608],[241,608]],"region":{"top_left_x":240,"top_left_y":545,"width":1181,"height":64},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44b1e86a77a540e1a00b761915714439","type":"section_header","conversion_output":false,"children_ids":["0f465785650d4a34937b0b0f24f55be4"],"text":"","text_display":""},{"cnt":[[245,550],[1416,550],[1416,604],[245,604]],"region":{"top_left_x":244,"top_left_y":550,"width":1172,"height":54},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f465785650d4a34937b0b0f24f55be4","type":"text","conversion_output":true,"parent_id":"44b1e86a77a540e1a00b761915714439","text":"13.2.3.1 The Platelia Aspergillus EIA and Fungitell Assay in Adults","text_display":"\n\n\\subsection*{13.2.3.1 The Platelia Aspergillus EIA and Fungitell Assay in Adults}","confidence":1,"confidence_rate":1},{"cnt":[[245,597],[1882,597],[1882,647],[245,647]],"region":{"top_left_x":244,"top_left_y":597,"width":1639,"height":50},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f2c1f974db644388f62852a94069dc9","type":"text","conversion_output":true,"text":"The Platelia Aspergillus EIA is a commercially available kit from Bio-Rad Laboratories that utilizes an","text_display":"\n\nThe Platelia Aspergillus EIA is a commercially available kit from Bio-Rad Laboratories that utilizes an","confidence":1,"confidence_rate":1},{"cnt":[[245,640],[1880,640],[1880,690],[245,690]],"region":{"top_left_x":244,"top_left_y":640,"width":1636,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be6bec19e3e04908aa9d6860981ec199","type":"text","conversion_output":true,"text":"EB-A2 monoclonal antibody and sandwich technique for detection of GM. In 2003, the assay received","text_display":" EB-A2 monoclonal antibody and sandwich technique for detection of GM. In 2003, the assay received","confidence":1,"confidence_rate":1},{"cnt":[[245,683],[1880,683],[1880,733],[245,733]],"region":{"top_left_x":244,"top_left_y":683,"width":1636,"height":50},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"314b5983727442dba18d9641477df5fa","type":"text","conversion_output":true,"text":"FDA approval for use in adults after it was prospectively validated in a cohort of immunosuppressed","text_display":" FDA approval for use in adults after it was prospectively validated in a cohort of immunosuppressed","confidence":1,"confidence_rate":1},{"cnt":[[245,728],[1880,728],[1880,778],[245,778]],"region":{"top_left_x":244,"top_left_y":728,"width":1636,"height":50},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"000eb0c950aa4109b43766e4137a081b","type":"text","conversion_output":true,"text":"patients. \\({ }^{61}\\) This cohort included patients aged 16 years or older with various leukemias, lymphomas or","text_display":" patients. \\({ }^{61}\\) This cohort included patients aged 16 years or older with various leukemias, lymphomas or","confidence":1,"confidence_rate":1},{"cnt":[[245,773],[1880,773],[1880,821],[245,821]],"region":{"top_left_x":244,"top_left_y":773,"width":1636,"height":48},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07d8a60023514e269039efbc37c04f04","type":"text","conversion_output":true,"text":"those undergoing stem cell transplants. Twice a week testing was performed in 362 separate","text_display":" those undergoing stem cell transplants. Twice a week testing was performed in 362 separate","confidence":1,"confidence_rate":1},{"cnt":[[245,816],[1880,816],[1880,866],[245,866]],"region":{"top_left_x":244,"top_left_y":816,"width":1636,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66f0d80c44ed4cbfb5ed07bb3f0da126","type":"text","conversion_output":true,"text":"hospitalizations. Criteria for proven or probable invasive aspergillosis (IA) developed by the","text_display":" hospitalizations. Criteria for proven or probable invasive aspergillosis (IA) developed by the","confidence":1,"confidence_rate":1},{"cnt":[[245,862],[1880,862],[1880,909],[245,909]],"region":{"top_left_x":244,"top_left_y":861,"width":1636,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e58e5097cea14d4a8e5a97836b383b9f","type":"text","conversion_output":true,"text":"EORTC/MSG were used as the gold standard. This testing strategy resulted in \\(72.9 \\%\\) sensitivity, \\(94.7 \\%\\)","text_display":" EORTC/MSG were used as the gold standard. This testing strategy resulted in \\(72.9 \\%\\) sensitivity, \\(94.7 \\%\\)","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,904],[1880,904],[1880,952],[245,952]],"region":{"top_left_x":244,"top_left_y":904,"width":1636,"height":48},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3158a481f1cc49db9faad02bdb3d7000","type":"text","conversion_output":true,"text":"specificity, \\(61.3 \\%\\) positive predictive value (PPV), and \\(96.8 \\%\\) negative predictive value (NPV) for","text_display":" specificity, \\(61.3 \\%\\) positive predictive value (PPV), and \\(96.8 \\%\\) negative predictive value (NPV) for","confidence":1,"confidence_rate":1},{"cnt":[[245,950],[1880,950],[1880,999],[245,999]],"region":{"top_left_x":244,"top_left_y":949,"width":1636,"height":51},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ef8bf4f0e27468399213ac39be3fa3c","type":"text","conversion_output":true,"text":"detection of IA. Detection of GM preceded the time of definitive IA diagnosis in \\(96 \\%\\) of the proven IA","text_display":" detection of IA. Detection of GM preceded the time of definitive IA diagnosis in \\(96 \\%\\) of the proven IA","confidence":0.99560546875,"confidence_rate":0.9999595951687289},{"cnt":[[245,993],[1880,993],[1880,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":992,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"089649607d304bfa80e3382f286801ab","type":"text","conversion_output":true,"text":"cases by a median of 17 days. Two separate meta-analyses have since been performed which support the","text_display":" cases by a median of 17 days. Two separate meta-analyses have since been performed which support the","confidence":1,"confidence_rate":1},{"cnt":[[245,1036],[887,1036],[887,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1035,"width":644,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"950d32b861e143b0bf1ccaa6bf04cc5a","type":"text","conversion_output":true,"text":"usefulness of GM screening in adults. \\({ }^{34,62}\\)","text_display":" usefulness of GM screening in adults. \\({ }^{34,62}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1113],[1880,1113],[1880,1164],[245,1164]],"region":{"top_left_x":244,"top_left_y":1112,"width":1636,"height":53},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94673a5584484599a28f0a4406f665a2","type":"text","conversion_output":true,"text":"The Fungitell Assay (formerly Glucatell) is a commercially available kit from the Associates of Cape","text_display":"\n\nThe Fungitell Assay (formerly Glucatell) is a commercially available kit from the Associates of Cape","confidence":1,"confidence_rate":1},{"cnt":[[245,1160],[1880,1160],[1880,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1160,"width":1636,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3146560d223948c89dc2ab0ac38af672","type":"text","conversion_output":true,"text":"Cod, Inc. for the identification of BG in the serum of patients with IFI. This assay received FDA approval","text_display":" Cod, Inc. for the identification of BG in the serum of patients with IFI. This assay received FDA approval","confidence":1,"confidence_rate":1},{"cnt":[[245,1205],[1880,1205],[1880,1253],[245,1253]],"region":{"top_left_x":244,"top_left_y":1205,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfe88d760d204f83a2ff1165ed943707","type":"text","conversion_output":true,"text":"in May of 2004 to assist in the diagnosis of IFI. The operating characteristics of the assay have been","text_display":" in May of 2004 to assist in the diagnosis of IFI. The operating characteristics of the assay have been","confidence":1,"confidence_rate":1},{"cnt":[[245,1248],[1880,1248],[1880,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1248,"width":1636,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f0d22497d234017a18c116085fad506","type":"text","conversion_output":true,"text":"elucidated in multiple adult cohorts. The first included adult patients with newly diagnosed AML or","text_display":" elucidated in multiple adult cohorts. The first included adult patients with newly diagnosed AML or","confidence":1,"confidence_rate":1},{"cnt":[[245,1293],[1880,1293],[1880,1338],[245,1338]],"region":{"top_left_x":244,"top_left_y":1293,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"344a71c11709458d8efb8fd82c7109b8","type":"text","conversion_output":true,"text":"myelodysplastic syndrome undergoing initial Induction chemotherapy and receiving fungal prophylaxis","text_display":" myelodysplastic syndrome undergoing initial Induction chemotherapy and receiving fungal prophylaxis","confidence":1,"confidence_rate":1},{"cnt":[[245,1336],[1880,1336],[1880,1384],[245,1384]],"region":{"top_left_x":244,"top_left_y":1336,"width":1636,"height":48},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b27dedd0cf942c4b24a3505fd1aaf26","type":"text","conversion_output":true,"text":"with either caspofungin or itraconazole. \\({ }^{63}\\) The Fungitell Assay was performed in 283 patients twice a","text_display":" with either caspofungin or itraconazole. \\({ }^{63}\\) The Fungitell Assay was performed in 283 patients twice a","confidence":1,"confidence_rate":1},{"cnt":[[245,1379],[1880,1379],[1880,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1379,"width":1636,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc26084dd5354d2cb0e2598db4109715","type":"text","conversion_output":true,"text":"week for the duration of neutropenia resulting in sensitivity, specificity, PPV and NPV for diagnosing","text_display":" week for the duration of neutropenia resulting in sensitivity, specificity, PPV and NPV for diagnosing","confidence":1,"confidence_rate":1},{"cnt":[[245,1422],[1880,1422],[1880,1472],[245,1472]],"region":{"top_left_x":244,"top_left_y":1422,"width":1636,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b625861175ed4a48a1efd62ecb572a21","type":"text","conversion_output":true,"text":"proven or probable IFI of \\(100 \\%, 90 \\%, 43 \\%\\), and \\(100 \\%\\), respectively. More importantly, a positive","text_display":" proven or probable IFI of \\(100 \\%, 90 \\%, 43 \\%\\), and \\(100 \\%\\), respectively. More importantly, a positive","confidence":0.9975595474243164,"confidence_rate":0.9999767294580594},{"cnt":[[245,1470],[1880,1470],[1880,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1469,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3d7896e053443d996f7416ba022dbd8","type":"text","conversion_output":true,"text":"Fungitell Assay result was identified at a median of 10 days prior to the clinical diagnosis of IFI in this","text_display":" Fungitell Assay result was identified at a median of 10 days prior to the clinical diagnosis of IFI in this","confidence":1,"confidence_rate":1},{"cnt":[[245,1512],[363,1512],[363,1555],[245,1555]],"region":{"top_left_x":244,"top_left_y":1512,"width":120,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"669032ed5bb1463fa075e2ef93ba6b21","type":"text","conversion_output":true,"text":"cohort.","text_display":" cohort.","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[1880,1590],[1880,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1589,"width":1636,"height":51},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c9feb39090d4a178d6fdd457480ad87","type":"text","conversion_output":true,"text":"The second study evaluated 95 adult patients with fever and neutropenia down to 16 years of age. Thirty-","text_display":"\n\nThe second study evaluated 95 adult patients with fever and neutropenia down to 16 years of age. Thirty","confidence":1,"confidence_rate":1},{"cnt":[[245,1637],[1880,1637],[1880,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1637,"width":1636,"height":50},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0462b0e8db544583ae54bb776d3eb286","type":"text","conversion_output":true,"text":"eight patients with proven, probable or possible IFI were identified. The resultant sensitivity, specificity,","text_display":"eight patients with proven, probable or possible IFI were identified. The resultant sensitivity, specificity,","confidence":0.99951171875,"confidence_rate":0.9999957157942816},{"cnt":[[245,1680],[1880,1680],[1880,1727],[245,1727]],"region":{"top_left_x":244,"top_left_y":1680,"width":1636,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b59a5062b6849f3af0b8caf1f6eb9ff","type":"text","conversion_output":true,"text":"PPV and NPV were \\(97.4 \\%, 28.6 \\%, 55.2 \\%\\), and \\(92.3 \\%\\) respectively. The specificity reported was reduced","text_display":" PPV and NPV were \\(97.4 \\%, 28.6 \\%, 55.2 \\%\\), and \\(92.3 \\%\\) respectively. The specificity reported was reduced","confidence":0.994140625,"confidence_rate":0.999945588438798},{"cnt":[[245,1725],[1880,1725],[1880,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1725,"width":1636,"height":48},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32b2b6e01b3e45e4ba5dc120aad942e2","type":"text","conversion_output":true,"text":"as compared to results from the prior publication as they included possible as well as probable and proven","text_display":" as compared to results from the prior publication as they included possible as well as probable and proven","confidence":1,"confidence_rate":1},{"cnt":[[245,1766],[1837,1766],[1837,1815],[245,1815]],"region":{"top_left_x":244,"top_left_y":1766,"width":1593,"height":50},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49c89b8bea40422a8348261483bf17be","type":"text","conversion_output":true,"text":"cases of IFI. Positive Fungitell Assay results preceded clinical diagnosis of IFI by a median of 5 days. \\({ }^{64}\\)","text_display":" cases of IFI. 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A","text_display":" patients undergoing therapy for acute leukemias or bone marrow transplantation \\({ }^{35,65-67}\\) (see Table 1). 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Adult trial data for both of these assays are encouraging as they are almost always correct","text_display":" prophylaxis. Adult trial data for both of these assays are encouraging as they are almost always correct","confidence":1,"confidence_rate":1},{"cnt":[[245,1987],[1880,1987],[1880,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1987,"width":1636,"height":48},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09fc3c25e3c74746bc7dd22cfba65fb2","type":"text","conversion_output":true,"text":"when the results are negative (i.e., high NPV) and maintain a reasonable sensitivity for presence of IFI","text_display":" when the results are negative (i.e., high NPV) and maintain a reasonable sensitivity for presence of IFI","confidence":1,"confidence_rate":1},{"cnt":[[245,2032],[1880,2032],[1880,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2032,"width":1636,"height":50},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3429de133bb34409b64afbe292262349","type":"text","conversion_output":true,"text":"(i.e., high sensitivity). Certainly, they may be at risk for false positive results (i.e., low PPV) which could","text_display":" (i.e., high sensitivity). Certainly, they may be at risk for false positive results (i.e., low PPV) which could","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1880,2075],[1880,2125],[245,2125]],"region":{"top_left_x":244,"top_left_y":2075,"width":1636,"height":50},"line":105,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb2b83e3e0a646f993333b1993c0f934","type":"text","conversion_output":true,"text":"result in unnecessarily treating patients without an IFI. Despite this potential for overtreatment it is still","text_display":" result in unnecessarily treating patients without an IFI. Despite this potential for overtreatment it is still","confidence":1,"confidence_rate":1},{"cnt":[[245,2121],[1880,2121],[1880,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2120,"width":1636,"height":48},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb9cc3e80f26449c9f8718d060360325","type":"text","conversion_output":true,"text":"likely more desirable to have such results guide empiric antifungal decisions as opposed to the limited","text_display":" likely more desirable to have such results guide empiric antifungal decisions as opposed to the limited","confidence":1,"confidence_rate":1},{"cnt":[[245,2161],[1042,2161],[1042,2211],[245,2211]],"region":{"top_left_x":244,"top_left_y":2161,"width":798,"height":50},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b8f3d416b864383b37f574598cd945c","type":"text","conversion_output":true,"text":"current practice of persistent fever and neutropenia.","text_display":" current practice of persistent fever and neutropenia.","confidence":1,"confidence_rate":1},{"cnt":[[245,2252],[1880,2252],[1880,2299],[245,2299]],"region":{"top_left_x":244,"top_left_y":2251,"width":1636,"height":48},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"624ccc643251469fa422e91996ceb6ad","type":"text","conversion_output":true,"text":"However, before we can employ these biomarker assays as guides for initiating or escalating to empiric","text_display":"\n\nHowever, before we can employ these biomarker assays as guides for initiating or escalating to empiric","confidence":1,"confidence_rate":1},{"cnt":[[245,2295],[1878,2295],[1878,2344],[245,2344]],"region":{"top_left_x":244,"top_left_y":2294,"width":1634,"height":50},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a48f291183c41748948297a7b273256","type":"text","conversion_output":true,"text":"antifungal therapy in children we must better define their operating characteristics in the same population.","text_display":" antifungal therapy in children we must better define their operating characteristics in the same population.","confidence":1,"confidence_rate":1},{"cnt":[[245,2337],[1880,2337],[1880,2387],[245,2387]],"region":{"top_left_x":244,"top_left_y":2337,"width":1636,"height":50},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"949faf9eadb7458baa8cc5bfeac977a4","type":"text","conversion_output":true,"text":"The parent study cohort provides a one time opportunity to evaluate the operating characteristics of both","text_display":" The parent study cohort provides a one time opportunity to evaluate the operating characteristics of both","confidence":1,"confidence_rate":1},{"cnt":[[245,2385],[1884,2385],[1884,2430],[245,2430]],"region":{"top_left_x":244,"top_left_y":2384,"width":1641,"height":46},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08343783e7824807b4171760584ae053","type":"text","conversion_output":true,"text":"of these tests in the setting of 2 different antifungal prophylaxis agents in a homogeneous cohort of","text_display":" of these tests in the setting of 2 different antifungal prophylaxis agents in a homogeneous cohort of","confidence":1,"confidence_rate":1},{"cnt":[[245,2428],[1880,2428],[1880,2477],[245,2477]],"region":{"top_left_x":244,"top_left_y":2427,"width":1636,"height":51},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0714a4f997b4a38aeaf7049d2a50512","type":"text","conversion_output":true,"text":"pediatric AML patients. The choice of which antifungal agent to use for future trials will likely be","text_display":" pediatric AML patients. The choice of which antifungal agent to use for future trials will likely be","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[614,2582],[614,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":371,"height":42},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d39232f262542f7a6aaa4da12de6549","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1880,2582],[1880,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":132,"height":46},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4dc48f35d57c47f8819ebdb3d2a86c98","type":"page_info","conversion_output":false,"text":"Page 44","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"30d0fca4-08d7-48bb-b63f-1324b67d52fd-45","page":45,"lines":[{"cnt":[[262,88],[436,88],[436,122],[262,122]],"region":{"top_left_x":262,"top_left_y":88,"width":175,"height":35},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4a5fa56191d1478592187a69c3e83291","type":"page_info","conversion_output":false,"text":"CHILDREN'S","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,120],[415,120],[415,157],[262,157]],"region":{"top_left_x":262,"top_left_y":120,"width":153,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c51d56be8fb644a29a9928cf01c8548d","type":"page_info","conversion_output":false,"text":"ONCOLOGY","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[494,133],[1493,133],[1493,170],[494,170]],"region":{"top_left_x":494,"top_left_y":133,"width":1000,"height":37},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d100405becf64cdcad536299404882cf","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.611114175756893,"confidence_rate":0.9938630153138378},{"cnt":[[1693,125],[1880,125],[1880,165],[1693,165]],"region":{"top_left_x":1692,"top_left_y":124,"width":188,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e89c2c7db7274bfbac17c21466d862e7","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[363,155],[363,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":102,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6de95076637842fc8afd947ddd007494","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1880,249],[1880,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1636,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"531a062f5bf449c19920cb97b39225bf","type":"text","conversion_output":true,"text":"determined by the results of this study. Knowledge of the operating characteristics of each biomarker","text_display":"\ndetermined by the results of this study. Knowledge of the operating characteristics of each biomarker","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cebcb0ccbd7d4611b9edd64aecf17128","type":"text","conversion_output":true,"text":"interpreted separately and in combination under these study conditions is necessary to inform their","text_display":" interpreted separately and in combination under these study conditions is necessary to inform their","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1725,339],[1725,387],[245,387]],"region":{"top_left_x":244,"top_left_y":339,"width":1482,"height":48},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5293ba2b00ca431884429cd66b6e9cbe","type":"text","conversion_output":true,"text":"potential utility as integral markers to guide empiric antifungal choices for future AML patients.","text_display":" potential utility as integral markers to guide empiric antifungal choices for future AML patients.","confidence":1,"confidence_rate":1},{"cnt":[[243,425],[608,425],[608,483],[243,483]],"region":{"top_left_x":242,"top_left_y":425,"width":367,"height":59},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eafe117f397242aba81274e65a714c81","type":"section_header","conversion_output":false,"children_ids":["5aa73a83a50a46ffbffb755394a3e67f"],"text":"","text_display":""},{"cnt":[[249,430],[604,430],[604,479],[249,479]],"region":{"top_left_x":249,"top_left_y":429,"width":355,"height":51},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5aa73a83a50a46ffbffb755394a3e67f","type":"text","conversion_output":true,"parent_id":"eafe117f397242aba81274e65a714c81","text":"13.3 Specific Aims","text_display":"\n\n\\subsection*{13.3 Specific Aims}","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[462,520],[462,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":218,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1103f5b39e804e1480ac693f50b59b2b","type":"text","conversion_output":true,"text":"Primary Aim:","text_display":"\n\nPrimary Aim:","confidence":1,"confidence_rate":1},{"cnt":[[245,561],[1880,561],[1880,608],[245,608]],"region":{"top_left_x":244,"top_left_y":560,"width":1636,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"767e391c9ea64f08b3e1ebab8f79c3c0","type":"text","conversion_output":true,"text":"i) To define the operating characteristics of 2 fungal antigen assays, Platelia Aspergillus EIA and","text_display":"\ni) To define the operating characteristics of 2 fungal antigen assays, Platelia Aspergillus EIA and","confidence":1,"confidence_rate":1},{"cnt":[[370,606],[1880,606],[1880,655],[370,655]],"region":{"top_left_x":369,"top_left_y":605,"width":1511,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dc938abd8394c65834648cd5838e5f1","type":"text","conversion_output":true,"text":"Fungitell Assay for the identification of IA only and all IFI among pediatric AML patients","text_display":" Fungitell Assay for the identification of IA only and all IFI among pediatric AML patients","confidence":1,"confidence_rate":1},{"cnt":[[370,649],[1497,649],[1497,698],[370,698]],"region":{"top_left_x":369,"top_left_y":648,"width":1129,"height":51},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c504a20bfdc479f84fb0334ea857015","type":"text","conversion_output":true,"text":"receiving antifungal prophylaxis. This primary aim will have 3 sub-aims:","text_display":" receiving antifungal prophylaxis. This primary aim will have 3 sub-aims:","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1880,735],[1880,784],[245,784]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acb2a7a159624fe4b9b846b997b5a220","type":"text","conversion_output":true,"text":"a) Define the test characteristics using a combination of the results from the Platelia Aspergillus EIA","text_display":"\na) Define the test characteristics using a combination of the results from the Platelia Aspergillus EIA","confidence":1,"confidence_rate":1},{"cnt":[[370,782],[1222,782],[1222,827],[370,827]],"region":{"top_left_x":369,"top_left_y":782,"width":854,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab48d76bc8db446f84c5e35a1549ca3b","type":"text","conversion_output":true,"text":"and Fungitell Assay for identifying IA only and all IFI.","text_display":" and Fungitell Assay for identifying IA only and all IFI.","confidence":1,"confidence_rate":1},{"cnt":[[370,825],[1880,825],[1880,874],[370,874]],"region":{"top_left_x":369,"top_left_y":825,"width":1511,"height":50},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc0c0643aef0404696a9403380e1d3ad","type":"text","conversion_output":true,"text":"Hypothesis: A positive Platelia Aspergillus EIA or positive Fungitell Assay will be more","text_display":"\nHypothesis: A positive Platelia Aspergillus EIA or positive Fungitell Assay will be more","confidence":1,"confidence_rate":1},{"cnt":[[370,870],[1880,870],[1880,917],[370,917]],"region":{"top_left_x":369,"top_left_y":870,"width":1511,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"324d0a6c106942afa919aee92bf64b27","type":"text","conversion_output":true,"text":"sensitive at identifying patients with IA only or with IFI while on antifungal prophylaxis as","text_display":" sensitive at identifying patients with IA only or with IFI while on antifungal prophylaxis as","confidence":0.92626953125,"confidence_rate":0.9992187745378355},{"cnt":[[370,915],[827,915],[827,960],[370,960]],"region":{"top_left_x":369,"top_left_y":915,"width":459,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3bd1e5875c454f71b9b4a34c3fe44417","type":"text","conversion_output":true,"text":"compared to either test alone.","text_display":" compared to either test alone.","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[1521,958],[1521,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":958,"width":1278,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"949c23f3919f4db790ee3d5a84ea5688","type":"text","conversion_output":true,"text":"b) Define the test characteristics of the Fungitell Assay for identifying all IFI.","text_display":"\nb) Define the test characteristics of the Fungitell Assay for identifying all IFI.","confidence":1,"confidence_rate":1},{"cnt":[[370,1001],[1880,1001],[1880,1051],[370,1051]],"region":{"top_left_x":369,"top_left_y":1001,"width":1511,"height":50},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d83a7c6dc3024b3e9fdcc9d0f5f9e4bf","type":"text","conversion_output":true,"text":"Hypothesis: A single positive Fungitell Assay will have \\(>90 \\%\\) sensitivity in identifying all IFI in","text_display":"\n\nHypothesis: A single positive Fungitell Assay will have \\(>90 \\%\\) sensitivity in identifying all IFI in","confidence":1,"confidence_rate":1},{"cnt":[[370,1044],[1145,1044],[1145,1094],[370,1094]],"region":{"top_left_x":369,"top_left_y":1044,"width":777,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c86fcca22c7441cae33d73e351f3050","type":"text","conversion_output":true,"text":"pediatric AML patients on antifungal prophylaxis.","text_display":" pediatric AML patients on antifungal prophylaxis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[1618,1091],[1618,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1091,"width":1374,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae513c2542154c03a3d85baa1732fc55","type":"text","conversion_output":true,"text":"c) Define the test characteristics of Platelia Aspergillus EIA for identifying IA only.","text_display":"\nc) Define the test characteristics of Platelia Aspergillus EIA for identifying IA only.","confidence":1,"confidence_rate":1},{"cnt":[[370,1134],[1880,1134],[1880,1182],[370,1182]],"region":{"top_left_x":369,"top_left_y":1134,"width":1511,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f4892f8f148421dbe199a1277a6df9c","type":"text","conversion_output":true,"text":"Hypothesis: A single positive Platelia Aspergillus EIA will have \\(>90 \\%\\) sensitivity in identifying","text_display":"\n\nHypothesis: A single positive Platelia Aspergillus EIA will have \\(>90 \\%\\) sensitivity in identifying","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[370,1177],[1313,1177],[1313,1227],[370,1227]],"region":{"top_left_x":369,"top_left_y":1177,"width":944,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6c0cdb3720441cd847a35246a941989","type":"text","conversion_output":true,"text":"IA only in pediatric AML patients on antifungal prophylaxis.","text_display":" IA only in pediatric AML patients on antifungal prophylaxis.","confidence":1,"confidence_rate":1},{"cnt":[[243,1263],[642,1263],[642,1317],[243,1317]],"region":{"top_left_x":242,"top_left_y":1263,"width":401,"height":54},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ad8d1b6ff2a41768e1a14b8fd710dbf","type":"section_header","conversion_output":false,"children_ids":["897fad97c47a4e3bb6cbdbbf639c3667"],"text":"","text_display":""},{"cnt":[[247,1268],[638,1268],[638,1313],[247,1313]],"region":{"top_left_x":247,"top_left_y":1267,"width":392,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"897fad97c47a4e3bb6cbdbbf639c3667","type":"text","conversion_output":true,"parent_id":"6ad8d1b6ff2a41768e1a14b8fd710dbf","text":"13.4 Patient Accrual","text_display":"\n\n\\subsection*{13.4 Patient Accrual}","confidence":1,"confidence_rate":1},{"cnt":[[245,1313],[1880,1313],[1880,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1312,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc6cdf2253ac48d8ae65c608be4d4265","type":"text","conversion_output":true,"text":"All patients enrolled on ACCL0933 will be offered the chance to participate in the anti-fungal screening","text_display":"\n\nAll patients enrolled on ACCL0933 will be offered the chance to participate in the anti-fungal screening","confidence":1,"confidence_rate":1},{"cnt":[[245,1358],[1880,1358],[1880,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1357,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9d9512617664142ba0b9c3a33199fdb","type":"text","conversion_output":true,"text":"study. We anticipate that at least \\(80 \\%\\) of the patients in the parent trial will enroll in this ancillary study","text_display":" study. We anticipate that at least \\(80 \\%\\) of the patients in the parent trial will enroll in this ancillary study","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1880,1401],[1880,1448],[245,1448]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":49},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e208a442e8b4971b2ff3a6214f514e0","type":"text","conversion_output":true,"text":"resulting in an estimated 440 patients at baseline. Those who consent will undergo Platelia Aspergillus","text_display":" resulting in an estimated 440 patients at baseline. Those who consent will undergo Platelia Aspergillus","confidence":1,"confidence_rate":1},{"cnt":[[245,1444],[1880,1444],[1880,1491],[245,1491]],"region":{"top_left_x":244,"top_left_y":1443,"width":1636,"height":49},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84a7153ec6934c088208038754bf626c","type":"text","conversion_output":true,"text":"EIA and Fungitell Assay testing. Blood sampling will be conducted twice weekly during anti-fungal","text_display":" EIA and Fungitell Assay testing. 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Based on data from the AAML0531 trial, we have estimated the","text_display":" variable durations of neutropenia. 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IA}","confidence":1,"confidence_rate":1},{"cnt":[[245,518],[1880,518],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":517,"width":1636,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e0f855a7c894b168d9cf7c5b4e6b327","type":"text","conversion_output":true,"text":"The EORTC/MSG guidelines incorporate clinical, microbiologic, histopathologic, and radiographic data","text_display":"\n\nThe EORTC/MSG guidelines incorporate clinical, microbiologic, histopathologic, and radiographic data","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":47},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62f6ee46256d471aaf036f47260e49c4","type":"text","conversion_output":true,"text":"for classification of proven or probable IFI or IA. Therefore, in order to establish these diagnoses, the","text_display":" for classification of proven or probable IFI or IA. Therefore, in order to establish these diagnoses, the","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1880,606],[1880,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1636,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9aa900d96b5d416fa9bbbb4b2a7e1f52","type":"text","conversion_output":true,"text":"following data will be obtained (according to the IFI checklist (Section 10.2): pathology reports","text_display":" following data will be obtained (according to the IFI checklist (Section 10.2): pathology reports","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1880,649],[1880,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":1636,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"609cf8d677fa4326ad29df7b8dbf3ba3","type":"text","conversion_output":true,"text":"(including autopsy reports), CT scan and MRI reports, fungal gram stain and microbiology culture results,","text_display":" (including autopsy reports), CT scan and MRI reports, fungal gram stain and microbiology culture results,","confidence":1,"confidence_rate":1},{"cnt":[[245,694],[1880,694],[1880,741],[245,741]],"region":{"top_left_x":244,"top_left_y":693,"width":1636,"height":49},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dddc6f4d95d459983244496d1f0bb44","type":"text","conversion_output":true,"text":"non-culture mycology testing results (i.e. histoplasma urine antigens, cryptococcal CSF and serum","text_display":" non-culture mycology testing results (i.e. histoplasma urine antigens, cryptococcal CSF and serum","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[1880,739],[1880,784],[245,784]],"region":{"top_left_x":244,"top_left_y":739,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb73f0068f054f1eb9d08d7ba5d08e5a","type":"text","conversion_output":true,"text":"antigens), ophthalmology exams, and bronchoscopy reports. An independent data review committee","text_display":" antigens), ophthalmology exams, and bronchoscopy reports. An independent data review committee","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1880,782],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":782,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5edcd9140b8c403baea91a014fa6d82b","type":"text","conversion_output":true,"text":"including infectious disease and oncology experts who are unaware of treatment assignments will review","text_display":" including infectious disease and oncology experts who are unaware of treatment assignments will review","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1742,825],[1742,874],[245,874]],"region":{"top_left_x":244,"top_left_y":825,"width":1499,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6692c835da44ea682f2e70bd12f34fa","type":"text","conversion_output":true,"text":"and classify all cases of fungal infection according to the consensus criteria of the EORTC/MSG.","text_display":" and classify all cases of fungal infection according to the consensus criteria of the EORTC/MSG.","confidence":1,"confidence_rate":1},{"cnt":[[241,911],[971,911],[971,971],[241,971]],"region":{"top_left_x":240,"top_left_y":910,"width":732,"height":62},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cca7d285c7914193932c2502769c439a","type":"section_header","conversion_output":false,"children_ids":["b389ec04188449578545b8fade032d9b"],"text":"","text_display":""},{"cnt":[[245,915],[965,915],[965,965],[245,965]],"region":{"top_left_x":244,"top_left_y":915,"width":721,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b389ec04188449578545b8fade032d9b","type":"text","conversion_output":true,"parent_id":"cca7d285c7914193932c2502769c439a","text":"13.6.1 Justification of Methodologic Choices","text_display":"\n\n\\subsection*{13.6.1 Justification of Methodologic Choices}","confidence":1,"confidence_rate":1},{"cnt":[[241,999],[1691,999],[1691,1059],[241,1059]],"region":{"top_left_x":240,"top_left_y":999,"width":1451,"height":61},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df682a22beb943a0b330f6aac0d8a5fc","type":"section_header","conversion_output":false,"children_ids":["dca4da9a65a64e9e813ed8b8e3e7fbff"],"text":"","text_display":""},{"cnt":[[245,1003],[1682,1003],[1682,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1003,"width":1439,"height":52},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dca4da9a65a64e9e813ed8b8e3e7fbff","type":"text","conversion_output":true,"parent_id":"df682a22beb943a0b330f6aac0d8a5fc","text":"13.6.1.1 Justification for Chosen Thresholds for Platelia Aspergillus EIA and Fungitell Assay","text_display":"\n\n\\subsection*{13.6.1.1 Justification for Chosen Thresholds for Platelia Aspergillus EIA and Fungitell Assay}","confidence":1,"confidence_rate":1},{"cnt":[[245,1051],[1880,1048],[1880,1098],[245,1100]],"region":{"top_left_x":244,"top_left_y":1048,"width":1636,"height":52},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2f66eac8bf24dd699ea77e547e4b7f5","type":"text","conversion_output":true,"text":"IFI outcomes are often devastating, thus it would be desirable to optimize sensitivity at the potential","text_display":"\n\nIFI outcomes are often devastating, thus it would be desirable to optimize sensitivity at the potential","confidence":1,"confidence_rate":1},{"cnt":[[245,1094],[1880,1094],[1880,1141],[245,1141]],"region":{"top_left_x":244,"top_left_y":1093,"width":1636,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af2f9011f68249579475d8ccab2f8ccc","type":"text","conversion_output":true,"text":"expense of specificity. Furthermore, a highly sensitive test will likely result in a high negative predictive","text_display":" expense of specificity. Furthermore, a highly sensitive test will likely result in a high negative predictive","confidence":1,"confidence_rate":1},{"cnt":[[245,1139],[1880,1139],[1880,1184],[245,1184]],"region":{"top_left_x":244,"top_left_y":1138,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87d9ef82b1e34eee95dfd0d3312122c6","type":"text","conversion_output":true,"text":"value. Clinicians caring for patients with positive tests would then have a heightened concern for IFI","text_display":" value. Clinicians caring for patients with positive tests would then have a heightened concern for IFI","confidence":1,"confidence_rate":1},{"cnt":[[245,1182],[1880,1182],[1880,1229],[245,1229]],"region":{"top_left_x":244,"top_left_y":1181,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11cb3c84a5ea462cbff3aa369cb29b01","type":"text","conversion_output":true,"text":"while a negative test result would reassure them that no further modifications to antifungal therapy are","text_display":" while a negative test result would reassure them that no further modifications to antifungal therapy are","confidence":0.9970715045928955,"confidence_rate":0.9999730940148176},{"cnt":[[245,1225],[1878,1225],[1878,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1224,"width":1634,"height":51},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df070e30b89b4600a0005c2ba104a9a1","type":"text","conversion_output":true,"text":"necessary at that time. It was with these intentions that the following threshold values were chosen to","text_display":" necessary at that time. It was with these intentions that the following threshold values were chosen to","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1145,1268],[1145,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1267,"width":902,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"598b5b6de41445ff9d69b387a09e9ea6","type":"text","conversion_output":true,"text":"conclude negative and positive results for each biomarker.","text_display":" conclude negative and positive results for each biomarker.","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1880,1354],[1880,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1353,"width":1636,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4886a63c653f4f9aa7485bf4a61cdfa0","type":"text","conversion_output":true,"text":"The level of \\(\\geq 0.5\\) GM index for Platelia Aspergillus EIA will be the established threshold to determine a","text_display":"\n\nThe level of \\(\\geq 0.5\\) GM index for Platelia Aspergillus EIA will be the established threshold to determine a","confidence":0.56591796875,"confidence_rate":0.9949298064824025},{"cnt":[[245,1401],[1880,1401],[1880,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":51},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"456bc6b4571e4d37813bc1d395043a07","type":"text","conversion_output":true,"text":"positive result. This is the level that was established for FDA approval during testing in adults. The","text_display":" positive result. This is the level that was established for FDA approval during testing in adults. The","confidence":1,"confidence_rate":1},{"cnt":[[245,1446],[1880,1446],[1880,1493],[245,1493]],"region":{"top_left_x":244,"top_left_y":1445,"width":1636,"height":49},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7fa4f403d484b0b9a62184eb1e8c75f","type":"text","conversion_output":true,"text":"operating characteristics of this test have been evaluated in pediatric and adult patients using various","text_display":" operating characteristics of this test have been evaluated in pediatric and adult patients using various","confidence":1,"confidence_rate":1},{"cnt":[[245,1489],[1880,1489],[1880,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1488,"width":1636,"height":49},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c903852ca30741f9b489b6d672163086","type":"text","conversion_output":true,"text":"cutoffs ranging from 0.5 to 1.5 as well as using single and consecutive positive results. Increasing the","text_display":" cutoffs ranging from 0.5 to 1.5 as well as using single and consecutive positive results. Increasing the","confidence":1,"confidence_rate":1},{"cnt":[[245,1534],[1878,1534],[1878,1579],[245,1579]],"region":{"top_left_x":244,"top_left_y":1533,"width":1634,"height":47},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36c662e17e8c4ec3839eb6a42f6c10f4","type":"text","conversion_output":true,"text":"threshold level and requiring multiple consecutive positive results often reduced the sensitivity while","text_display":" threshold level and requiring multiple consecutive positive results often reduced the sensitivity while","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[245,1577],[1880,1577],[1880,1624],[245,1624]],"region":{"top_left_x":244,"top_left_y":1576,"width":1636,"height":49},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad3d2f745a7c426aac07b763b730bb13","type":"text","conversion_output":true,"text":"optimizing specificity. As noted above, our goal is to optimize sensitivity and negative predictive value, at","text_display":" optimizing specificity. As noted above, our goal is to optimize sensitivity and negative predictive value, at","confidence":1,"confidence_rate":1},{"cnt":[[245,1620],[1880,1620],[1880,1669],[245,1669]],"region":{"top_left_x":244,"top_left_y":1619,"width":1636,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e58f5e67e0e4c06a59b133dc2611248","type":"text","conversion_output":true,"text":"the risk of lower specificity and positive predictive value. Therefore, the lower threshold of \\(\\geq 0.5\\) on a","text_display":" the risk of lower specificity and positive predictive value. Therefore, the lower threshold of \\(\\geq 0.5\\) on a","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[604,1663],[604,1712],[245,1712]],"region":{"top_left_x":244,"top_left_y":1662,"width":360,"height":51},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8b5a4d8dff7496bb085f64893934a42","type":"text","conversion_output":true,"text":"single test was chosen.","text_display":" single test was chosen.","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1880,1749],[1880,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1748,"width":1636,"height":51},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f92be0bf5f03464190175b423eed16c6","type":"text","conversion_output":true,"text":"The Fungitell Assay threshold result of \\(\\geq 80 pg / mL\\) was chosen based on manufacturer recommendations","text_display":"\n\nThe Fungitell Assay threshold result of \\(\\geq 80 pg / mL\\) was chosen based on manufacturer recommendations","confidence":1,"confidence_rate":1},{"cnt":[[245,1796],[1880,1796],[1880,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1796,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab83e8d6b3974387a98433d403e1bda2","type":"text","conversion_output":true,"text":"and available data. For two adult studies that evaluated this test, the cut-off for a positive test was lowered","text_display":" and available data. For two adult studies that evaluated this test, the cut-off for a positive test was lowered","confidence":1,"confidence_rate":1},{"cnt":[[245,1839],[1880,1839],[1880,1888],[245,1888]],"region":{"top_left_x":244,"top_left_y":1839,"width":1636,"height":50},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa936046797e4e68a579d841a59d166b","type":"text","conversion_output":true,"text":"to \\(>60 pg / mL .{ }^{63,64}\\) Lowering of the manufacturer threshold in these two studies resulted in high","text_display":" to \\(>60 pg / mL .{ }^{63,64}\\) Lowering of the manufacturer threshold in these two studies resulted in high","confidence":0.87646484375,"confidence_rate":0.9988540598285474},{"cnt":[[245,1882],[1880,1882],[1880,1931],[245,1931]],"region":{"top_left_x":244,"top_left_y":1882,"width":1636,"height":50},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"238af7330c9643ac848d0b09d972a2cb","type":"text","conversion_output":true,"text":"sensitivity which would be consistent with the goals of our study. However, analysis of BG levels in 120","text_display":" sensitivity which would be consistent with the goals of our study. However, analysis of BG levels in 120","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1880,1925],[1880,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1925,"width":1636,"height":50},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7bf7776801964c4fbb0db3f0d5633cc7","type":"text","conversion_output":true,"text":"healthy children revealed that \\(22 \\%\\) of them had BG levels greater than \\(60 pg / mL .{ }^{68}\\) Although this level","text_display":" healthy children revealed that \\(22 \\%\\) of them had BG levels greater than \\(60 pg / mL .{ }^{68}\\) Although this level","confidence":0.6243897974491119,"confidence_rate":0.9962089748727829},{"cnt":[[245,1972],[1880,1972],[1880,2020],[245,2020]],"region":{"top_left_x":244,"top_left_y":1972,"width":1636,"height":48},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10f1566f9deb4e149535152f48c4d0a5","type":"text","conversion_output":true,"text":"would optimize sensitivity, the likelihood for false positivity is too high. There were still \\(15 \\%\\) of healthy","text_display":" would optimize sensitivity, the likelihood for false positivity is too high. There were still \\(15 \\%\\) of healthy","confidence":1,"confidence_rate":1},{"cnt":[[245,2015],[1880,2015],[1880,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2015,"width":1636,"height":50},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"953b2b304b844c7b8b3ba7eefea2ab97","type":"text","conversion_output":true,"text":"children in this study that had a level of \\(\\geq 80 pg / mL\\). This suggests that even at a level of \\(\\geq 80 pg / mL\\),","text_display":" children in this study that had a level of \\(\\geq 80 pg / mL\\). This suggests that even at a level of \\(\\geq 80 pg / mL\\),","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1882,2058],[1882,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":1639,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"247bad716c394807a48c05d7018aeb5b","type":"text","conversion_output":true,"text":"sensitivity of this assay in children would be preserved. Therefore, the manufacturer threshold of","text_display":" sensitivity of this assay in children would be preserved. Therefore, the manufacturer threshold of","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1880,2105],[1880,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2105,"width":1636,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49c181983a664da7ae2c9a551f1ea437","type":"text","conversion_output":true,"text":"\\(\\geq 80 pg / mL\\) was chosen. For both biomarker assays, a post hoc analysis of various cutoffs as well as","text_display":" \\(\\geq 80 pg / mL\\) was chosen. For both biomarker assays, a post hoc analysis of various cutoffs as well as","confidence":1,"confidence_rate":1},{"cnt":[[245,2148],[1884,2148],[1884,2196],[245,2196]],"region":{"top_left_x":244,"top_left_y":2148,"width":1641,"height":48},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c21bc2eb73d2494a959f8689b21cd6d6","type":"text","conversion_output":true,"text":"assessment of sequential positive testing will be performed in an attempt to identify the most ideal cut-off","text_display":" assessment of sequential positive testing will be performed in an attempt to identify the most ideal cut-off","confidence":1,"confidence_rate":1},{"cnt":[[245,2191],[1624,2191],[1624,2241],[245,2241]],"region":{"top_left_x":244,"top_left_y":2191,"width":1381,"height":50},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15eb717855194fe19a11c6a1db645ba1","type":"text","conversion_output":true,"text":"for future use of this assay as an integral biomarker (please see statistical analysis below).","text_display":" for future use of this assay as an integral biomarker (please see statistical analysis below).","confidence":1,"confidence_rate":1},{"cnt":[[243,2273],[922,2273],[922,2329],[243,2329]],"region":{"top_left_x":242,"top_left_y":2273,"width":680,"height":56},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c05f60f0c854352aa7943de5e3614a5","type":"section_header","conversion_output":false,"children_ids":["6d4385e295c143698bb96a5e932898ac"],"text":"","text_display":""},{"cnt":[[247,2277],[917,2277],[917,2322],[247,2322]],"region":{"top_left_x":247,"top_left_y":2277,"width":671,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d4385e295c143698bb96a5e932898ac","type":"text","conversion_output":true,"parent_id":"9c05f60f0c854352aa7943de5e3614a5","text":"13.6.1.2 Justification for IFI Gold Standard","text_display":"\n\n\\subsection*{13.6.1.2 Justification for IFI Gold Standard}","confidence":1,"confidence_rate":1},{"cnt":[[245,2322],[1880,2322],[1880,2374],[245,2374]],"region":{"top_left_x":244,"top_left_y":2322,"width":1636,"height":53},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6e8b9f4168b411aac0bc50e3333e52d","type":"text","conversion_output":true,"text":"We have chosen to use EORTC/MSG defined proven or probable IA or IFI (Appendix II) as the gold","text_display":"\n\nWe have chosen to use EORTC/MSG defined proven or probable IA or IFI (Appendix II) as the gold","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1880,2368],[1880,2417],[245,2417]],"region":{"top_left_x":244,"top_left_y":2367,"width":1636,"height":50},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"764f696e70cc4b7ab77a7f45af9b0249","type":"text","conversion_output":true,"text":"standard. The ideal gold standard to compare to each biomarker would be a positive culture of a fungal","text_display":" standard. The ideal gold standard to compare to each biomarker would be a positive culture of a fungal","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,2411],[1880,2411],[1880,2460],[245,2460]],"region":{"top_left_x":244,"top_left_y":2410,"width":1636,"height":50},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d3c34bbc8824ff9a3b5a4704c36e66b","type":"text","conversion_output":true,"text":"organism from blood or infected tissue. However, there are significant challenges to establish the","text_display":" organism from blood or infected tissue. However, there are significant challenges to establish the","confidence":1,"confidence_rate":1},{"cnt":[[245,2454],[1880,2454],[1880,2505],[245,2505]],"region":{"top_left_x":244,"top_left_y":2453,"width":1636,"height":53},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"038602f3831249fc8d5694ec8d61937f","type":"text","conversion_output":true,"text":"presence of fungal infection with isolation of the etiologic organism. Certain molds such as Aspergillus","text_display":" presence of fungal infection with isolation of the etiologic organism. Certain molds such as Aspergillus","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[614,2582],[614,2625],[245,2625]],"region":{"top_left_x":244,"top_left_y":2582,"width":371,"height":44},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"646268499182415fb176cb9b7b6674a8","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1880,2582],[1880,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":132,"height":46},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae7f0eaa29054fbf8bd4bc12d8f19411","type":"page_info","conversion_output":false,"text":"Page 46","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"30d0fca4-08d7-48bb-b63f-1324b67d52fd-47","page":47,"lines":[{"cnt":[[262,86],[436,86],[436,122],[262,122]],"region":{"top_left_x":262,"top_left_y":85,"width":175,"height":38},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"23df0b5263704fd2bbecf3d34f68e616","type":"page_info","conversion_output":false,"text":"CHILDREN'S","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[262,120],[417,120],[417,157],[262,157]],"region":{"top_left_x":262,"top_left_y":120,"width":155,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"dca59f9b7aed4374bdc458f9ef1ecf94","type":"page_info","conversion_output":false,"text":"ONCOLOGY","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[494,129],[1497,129],[1497,170],[494,170]],"region":{"top_left_x":494,"top_left_y":128,"width":1004,"height":42},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"86eb9956c7ba422691d89f9441f85bdb","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.9761475823079309,"confidence_rate":0.999698276869841},{"cnt":[[1691,125],[1880,125],[1880,168],[1691,168]],"region":{"top_left_x":1690,"top_left_y":124,"width":190,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96f4c6ab1d3342b5bcb5afeb3cade9de","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[363,155],[363,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":102,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ff56cdb544f545788cd9a1a962529fe2","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1880,249],[1880,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1636,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecbde974dad3416491d21983bb1751b9","type":"text","conversion_output":true,"text":"do not grow routinely in blood cultures, the ability to obtain tissue for culture can be impacted by the size","text_display":"\ndo not grow routinely in blood cultures, the ability to obtain tissue for culture can be impacted by the size","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"518107fcbb124796850349c44d64fc74","type":"text","conversion_output":true,"text":"and location of a visceral lesion, and the clinical status of a patient may preclude invasive procedures to","text_display":" and location of a visceral lesion, and the clinical status of a patient may preclude invasive procedures to","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1876,339],[1876,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1632,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ee7db3b602f4f7d8522cf8ad76aa720","type":"text","conversion_output":true,"text":"obtain cultures. Therefore, an alternate endpoint to identify all patients who truly have IFI is necessary.","text_display":" obtain cultures. Therefore, an alternate endpoint to identify all patients who truly have IFI is necessary.","confidence":0.99853515625,"confidence_rate":0.9999869115349181},{"cnt":[[245,382],[1880,382],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1636,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"037c0087b551490db41319c9f3dcfe82","type":"text","conversion_output":true,"text":"This issue has been addressed by the EORTC/MSG. This group of experts initially created criteria based","text_display":" This issue has been addressed by the EORTC/MSG. This group of experts initially created criteria based","confidence":0.9990234375,"confidence_rate":0.9999908688300274},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53d51aaaa52040328ea78bc97429f9d5","type":"text","conversion_output":true,"text":"on clinical, radiographic and culture data to define possible, probable and proven IFI in 2002 and revised","text_display":" on clinical, radiographic and culture data to define possible, probable and proven IFI in 2002 and revised","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,468],[1880,468],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":468,"width":1636,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d5e60d010b14ddbbd30c887e4bf02bd","type":"text","conversion_output":true,"text":"these criteria in 2009. \\({ }^{48,70}\\) These criteria have served as the primary endpoint for major trials of antifungal","text_display":" these criteria in 2009. \\({ }^{48,70}\\) These criteria have served as the primary endpoint for major trials of antifungal","confidence":0.99072265625,"confidence_rate":0.9999260293523634},{"cnt":[[245,516],[1880,516],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad97268a91ee49059d5e6301002dac6b","type":"text","conversion_output":true,"text":"drug efficacy, in strategy trials, for formulating clinical practice guidelines, as well as for undertaking","text_display":" drug efficacy, in strategy trials, for formulating clinical practice guidelines, as well as for undertaking","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,608],[245,608]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f1cda27bcb840039108ed3dbdd67112","type":"text","conversion_output":true,"text":"epidemiologic studies. Consistent use of these criteria as the primary endpoint will allow for comparison","text_display":" epidemiologic studies. Consistent use of these criteria as the primary endpoint will allow for comparison","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[969,602],[969,651],[245,651]],"region":{"top_left_x":244,"top_left_y":601,"width":725,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97354b803d8f40b3b851d36dc09cb40f","type":"text","conversion_output":true,"text":"of the resultant data to prior and future studies.","text_display":" of the resultant data to prior and future studies.","confidence":1,"confidence_rate":1},{"cnt":[[241,683],[1063,683],[1063,741],[241,741]],"region":{"top_left_x":240,"top_left_y":683,"width":824,"height":59},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d21a4e7137884599a2893be31493f7c4","type":"section_header","conversion_output":false,"children_ids":["ebb62cc494a149eea936e23db091c6ac"],"text":"","text_display":""},{"cnt":[[245,688],[1059,688],[1059,737],[245,737]],"region":{"top_left_x":244,"top_left_y":687,"width":816,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebb62cc494a149eea936e23db091c6ac","type":"text","conversion_output":true,"parent_id":"d21a4e7137884599a2893be31493f7c4","text":"13.7 Factors resulting in False Positive Results","text_display":"\n\n\\subsection*{13.7 Factors resulting in False Positive Results}","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1884,735],[1884,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1641,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07248230819e48ca8bf94915fc3945e4","type":"text","conversion_output":true,"text":"A number of medications, medical interventions, and infections have been suggested as possible causes of","text_display":"\n\nA number of medications, medical interventions, and infections have been suggested as possible causes of","confidence":1,"confidence_rate":1},{"cnt":[[245,776],[1880,776],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":775,"width":1636,"height":53},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd116fc79eed430b9b0b42e344647ecc","type":"text","conversion_output":true,"text":"false positive results for BG and GM testing. \\({ }^{59,60,71}\\) Table 3 lists the potential causes of false positive","text_display":" false positive results for BG and GM testing. \\({ }^{59,60,71}\\) Table 3 lists the potential causes of false positive","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1880,821],[1880,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1636,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61a83469c0df4f83a117f4dcb1681acd","type":"text","conversion_output":true,"text":"results reported in the literature. It is anticipated that patients being treated for AML will have reason to","text_display":" results reported in the literature. It is anticipated that patients being treated for AML will have reason to","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,866],[1880,866],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":865,"width":1636,"height":49},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"455d6ae135c44090a0d3f533a8fa7dfb","type":"text","conversion_output":true,"text":"be exposed to a number of these medications, infusions and/or medical interventions. Additionally,","text_display":" be exposed to a number of these medications, infusions and/or medical interventions. Additionally,","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1880,911],[1880,958],[245,958]],"region":{"top_left_x":244,"top_left_y":910,"width":1636,"height":49},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e5488cb2edb454b81cefc97af21f0d1","type":"text","conversion_output":true,"text":"Pneumocystis jiroveci infection is also considered a cause of a \"false positive\" BG test. Technically this is","text_display":" Pneumocystis jiroveci infection is also considered a cause of a \"false positive\" BG test. Technically this is","confidence":0.9912109375,"confidence_rate":0.9999225651550432},{"cnt":[[245,954],[1880,954],[1880,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":953,"width":1636,"height":51},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4e6aa8798c44253a3891c63ddfdee77","type":"text","conversion_output":true,"text":"not a true false positive as the Fungitell Assay is detecting BG from the cell wall of Pneumocystis jiroveci","text_display":" not a true false positive as the Fungitell Assay is detecting BG from the cell wall of Pneumocystis jiroveci","confidence":1,"confidence_rate":1},{"cnt":[[245,999],[1880,999],[1880,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":999,"width":1636,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"828a848f68fa44e6b0f299b51ef0c3e2","type":"text","conversion_output":true,"text":"as it would for other fungal infections. However, in this instance it is considered a false positive as the","text_display":" as it would for other fungal infections. However, in this instance it is considered a false positive as the","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1880,1042],[1880,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1636,"height":49},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab90b8fde3a54afd9c457bfa8dc1747b","type":"text","conversion_output":true,"text":"treatment of choice for this infection is trimethoprim-sulfamethoxazole as opposed to a typical anti-fungal","text_display":" treatment of choice for this infection is trimethoprim-sulfamethoxazole as opposed to a typical anti-fungal","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1880,1087],[1880,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1636,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c3bc936ec2b45a4b02711da0870924b","type":"text","conversion_output":true,"text":"agent. A sensitivity analysis (as described in Section 13.8.4 below) will be performed to investigate the","text_display":" agent. A sensitivity analysis (as described in Section 13.8.4 below) will be performed to investigate the","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1583,1130],[1583,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1130,"width":1340,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3cff2bd058e4be09ca2d5510e965201","type":"text","conversion_output":true,"text":"impact of these false positive rates on the operating characteristics of the 2 biomarkers.","text_display":" impact of these false positive rates on the operating characteristics of the 2 biomarkers.","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[241,1214],[1790,1214],[1790,1278],[241,1278]],"region":{"top_left_x":240,"top_left_y":1213,"width":1550,"height":66},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6cd65c7b936146a1aeda3e298db28d77","type":"figure_label","conversion_output":false,"text":"Table 3. Potential factors resulting in false positive testing for ( \\(1 \\rightarrow 3\\) ) beta-D glucan and GM assays","text_display":"","confidence":0.97265625,"confidence_rate":0.9997479904141621},{"cnt":[[223,1336],[1914,1336],[1914,2052],[223,2052]],"region":{"top_left_x":223,"top_left_y":1336,"width":1692,"height":716},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"043fb77b73004b5d908bba4e1a65c12c","type":"table","conversion_output":true,"children_ids":["d7d31993e9d74a988c607f568dc2c9f9","6be708eba3314f00a46b709c76fbad77","a17e741006c44178816aa19093f6731f","917d85aca3a146ba8efc2b0d67056eab","661e2e11cdd74632a4192e139e8e92ad","e4d0ae7152cd4723a397a5bc6b9bf3c3","932fc6903a5f482592db64abd4b69195","5c26852359e047a694ef9e7321698517","7530210699cb4e1e8ca8019e97082b8c","8fd6ed7b9c7247efbc77fb8b04166a72","29c72daefe5f4494b168cbdf50c09088","26393c47e1014f5d8a7720b96e6979a9","709e4415de8c4635b701f04dac7a20f8","59cbc390857b4d25866b38534133bd5e","350cabc6aa064ce1a2804acbb4fdc657","5f94c7ee31894867b0f5c5a7e7931231","f07e158d1b6c4d5792c5542d10778b9d","b756ec028b684a6abfe3ec516a8eac0a","1c4e4c3d31d7416cbba2d6da7d5da475","3433bbe56b724cc4bbe7733a07b6a641","b3bd0b0303104f7bb552ff24ab775510","182f108d2e814c8997759cd21dffb04a","dce9471a86034a50b2a115a7f25f2379"],"selected_labels":["6cd65c7b936146a1aeda3e298db28d77"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Factor & ( \\(1 \\rightarrow 3\\) ) Beta-D Glucan Assay & Galactomannan EIA Assays \\\\\n\\hline Medications & Amoxicillin-clavulanate & \\begin{tabular}{l}\n*Piperacillin-Tazobactam \\\\\n*Amoxicillin-clavulanate\n\\end{tabular} \\\\\n\\hline Infusions & \\begin{tabular}{l}\n*Intravenous immune globulin \\\\\n*Cellulose filters for IV infusion \\\\\n*Albumin\n\\end{tabular} & \\begin{tabular}{l}\n*Plasmalyte (electrolyte infusion) \\\\\n*Intravenous solution with sodium gluconate\n\\end{tabular} \\\\\n\\hline Medical interventions & \\begin{tabular}{l}\n*Hemodialysis with cellulose filter \\\\\n*Gauze packing on serosal surfaces\n\\end{tabular} & *Enteral feeding with soybean proteins \\\\\n\\hline Other infections & *Pneumocystis jiroveci & \\begin{tabular}{l}\n*Penicillium spp. \\\\\n*Histoplasma capsulatum \\\\\n*Geotrichum \\\\\n*Neosartoria\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3. 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Statistical Design","text_display":"\n\n\\subsection*{13.8 Statistical Design}","confidence":1,"confidence_rate":1},{"cnt":[[243,2159],[995,2159],[995,2219],[243,2219]],"region":{"top_left_x":242,"top_left_y":2159,"width":753,"height":61},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f37b1bcc0b84f059113511cc61104bb","type":"section_header","conversion_output":false,"children_ids":["64e891cc3efb48d69d22e21d689cdaf3"],"text":"","text_display":""},{"cnt":[[247,2166],[990,2166],[990,2213],[247,2213]],"region":{"top_left_x":247,"top_left_y":2165,"width":744,"height":48},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64e891cc3efb48d69d22e21d689cdaf3","type":"text","conversion_output":true,"parent_id":"3f37b1bcc0b84f059113511cc61104bb","text":"13.8.1 Sample Size and Estimated Event Rates","text_display":"\n\n\\subsection*{13.8.1 Sample Size and Estimated Event Rates}","confidence":1,"confidence_rate":1},{"cnt":[[245,2209],[1880,2209],[1880,2258],[245,2258]],"region":{"top_left_x":244,"top_left_y":2208,"width":1636,"height":51},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"673a628b54f14f32a1533299a918591a","type":"text","conversion_output":true,"text":"The parent trial comparing prophylaxis with caspofungin to fluconazole in newly diagnosed AML","text_display":"\n\nThe parent trial comparing prophylaxis with caspofungin to fluconazole in newly diagnosed AML","confidence":1,"confidence_rate":1},{"cnt":[[245,2254],[1880,2254],[1880,2301],[245,2301]],"region":{"top_left_x":244,"top_left_y":2253,"width":1636,"height":48},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87e19fcc526f45a5b28a4c07cd8d22da","type":"text","conversion_output":true,"text":"patients anticipates enrollment of at least 275 patients for each arm with a total cohort of approximately","text_display":" patients anticipates enrollment of at least 275 patients for each arm with a total cohort of approximately","confidence":1,"confidence_rate":1},{"cnt":[[245,2297],[1880,2297],[1880,2344],[245,2344]],"region":{"top_left_x":244,"top_left_y":2296,"width":1636,"height":48},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7605969c41b54e7e96647095619a6213","type":"text","conversion_output":true,"text":"550 patients. As noted above we anticipate that at least \\(80 \\%\\) of the patients enrolled in the parent trial will","text_display":" 550 patients. As noted above we anticipate that at least \\(80 \\%\\) of the patients enrolled in the parent trial will","confidence":1,"confidence_rate":1},{"cnt":[[245,2342],[1880,2342],[1880,2391],[245,2391]],"region":{"top_left_x":244,"top_left_y":2341,"width":1636,"height":51},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"142068d147094f1ea929da1f79727f7c","type":"text","conversion_output":true,"text":"also be enrolled in this ancillary study. This will result in 220 patients from each study arm. Consent for","text_display":" also be enrolled in this ancillary study. This will result in 220 patients from each study arm. Consent for","confidence":1,"confidence_rate":1},{"cnt":[[245,2385],[1880,2385],[1880,2434],[245,2434]],"region":{"top_left_x":244,"top_left_y":2384,"width":1636,"height":51},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4dc9ef777eb64fc19ea09f35f8fade23","type":"text","conversion_output":true,"text":"testing will be included as a part of the parent trial enrollment, thus significantly limiting the need for","text_display":" testing will be included as a part of the parent trial enrollment, thus significantly limiting the need for","confidence":1,"confidence_rate":1},{"cnt":[[245,2430],[1081,2430],[1081,2477],[245,2477]],"region":{"top_left_x":244,"top_left_y":2429,"width":837,"height":49},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f844f4b197dc46379ac0d6fa312b99ee","type":"text","conversion_output":true,"text":"additional resources to complete this biomarker study.","text_display":" additional resources to complete this biomarker study.","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[614,2582],[614,2625],[245,2625]],"region":{"top_left_x":244,"top_left_y":2582,"width":371,"height":44},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3aefeef753a49af9f845107981142b3","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1880,2582],[1880,2632],[1749,2632]],"region":{"top_left_x":1748,"top_left_y":2582,"width":132,"height":50},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ebda185e70e4290a7f13f6a35ccb448","type":"page_info","conversion_output":false,"text":"Page 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estimated number of probable or proven IFI events for final analyses will be different for both","text_display":"\n\nThe estimated number of probable or proven IFI events for final analyses will be different for both","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06c18e5e3375465e8b6cd6c4e66e3fc5","type":"text","conversion_output":true,"text":"proposed biomarkers as they account for different types of fungal infections and the incidence for each","text_display":" proposed biomarkers as they account for different types of fungal infections and the incidence for each","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1880,382],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1636,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3503356b2cc49dda09ae27557ba23a9","type":"text","conversion_output":true,"text":"will vary by study arm. The Fungitell Assay has the potential to identify most pathogenic fungi and thus a","text_display":" will vary by study arm. The Fungitell Assay has the potential to identify most pathogenic fungi and thus a","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed4016bf31194d28afa12541f6fb17bf","type":"text","conversion_output":true,"text":"majority of the probable or proven IFIs will be considered as true events (excluding IFIs form","text_display":" majority of the probable or proven IFIs will be considered as true events (excluding IFIs form","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1880,471],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1636,"height":48},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c05db45d038442d19af859c531424190","type":"text","conversion_output":true,"text":"Zygomycetes and Cryptococci). The Platelia Aspergillus EIA is specific for Aspergillus and thus only","text_display":" Zygomycetes and Cryptococci). The Platelia Aspergillus EIA is specific for Aspergillus and thus only","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1364,516],[1364,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1121,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61633f9272d5435c9bf2600cc802b901","type":"text","conversion_output":true,"text":"probable or proven IA will be considered as true events for that analysis.","text_display":" probable or proven IA will be considered as true events for that analysis.","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1880,602],[1880,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1636,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ffc67bdd2f2480dbd1859aa1f70b370","type":"text","conversion_output":true,"text":"Based on Section 9.3.3 of the parent trial the estimated incidence of IFI for patients in the fluconazole","text_display":"\n\nBased on Section 9.3.3 of the parent trial the estimated incidence of IFI for patients in the fluconazole","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[245,645],[1878,645],[1878,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1634,"height":50},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44bfb851fc8047bcb3fb79de645e4118","type":"text","conversion_output":true,"text":"group is \\(8 \\%\\) and \\(2 \\%\\) in the caspofungin arm. Assuming the enrollment of 220 patients in each study arm,","text_display":" group is \\(8 \\%\\) and \\(2 \\%\\) in the caspofungin arm. Assuming the enrollment of 220 patients in each study arm,","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1880,692],[1880,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a3d35da4875485eb1d52b89a8c707a6","type":"text","conversion_output":true,"text":"there would 18 IFI events in the fluconazole group and 4 IFI events in the caspofungin group. Based on","text_display":" there would 18 IFI events in the fluconazole group and 4 IFI events in the caspofungin group. Based on","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1880,735],[1880,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca3772fff9114e39be9e33cd37ef1800","type":"text","conversion_output":true,"text":"data from the CCG 2961 AML trial, one-third of microbiologically proven fungal infection were the","text_display":" data from the CCG 2961 AML trial, one-third of microbiologically proven fungal infection were the","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1880,778],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1636,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee25c61a89404e56a46818798e42fa8c","type":"text","conversion_output":true,"text":"result of Aspergillus. Therefore, it is estimated that 6 of the 18 IFI events in the fluconazole group will be","text_display":" result of Aspergillus. Therefore, it is estimated that 6 of the 18 IFI events in the fluconazole group will be","confidence":0.99951171875,"confidence_rate":0.9999959636403931},{"cnt":[[245,821],[1442,821],[1442,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1198,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed4b3e2900a84228bc7040c1ea7af5c6","type":"text","conversion_output":true,"text":"IA and between 1 and 2 of the IFI events in the caspofungin group will be IA.","text_display":" IA and between 1 and 2 of the IFI events in the caspofungin group will be IA.","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[243,904],[982,904],[982,960],[243,960]],"region":{"top_left_x":242,"top_left_y":904,"width":740,"height":57},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb47962290bc401c9bb077f559d5621c","type":"section_header","conversion_output":false,"children_ids":["9d8c23d916d745b69b08168586b45971"],"text":"","text_display":""},{"cnt":[[249,911],[978,911],[978,956],[249,956]],"region":{"top_left_x":249,"top_left_y":910,"width":729,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d8c23d916d745b69b08168586b45971","type":"text","conversion_output":true,"parent_id":"eb47962290bc401c9bb077f559d5621c","text":"13.8.2 Sensitivity, Specificity, PPV, and NPV","text_display":"\n\n\\subsection*{13.8.2 Sensitivity, Specificity, PPV, and NPV}","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1880,954],[1880,999],[245,999]],"region":{"top_left_x":244,"top_left_y":953,"width":1636,"height":47},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8777b159276445ebbf472f8864c7a1ed","type":"text","conversion_output":true,"text":"The validity of a biomarker is based on whether the study appropriately categorizes patients with and","text_display":"\n\nThe validity of a biomarker is based on whether the study appropriately categorizes patients with and","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1880,997],[1880,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1636,"height":49},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00d38a4c648f407c8abcae651a925550","type":"text","conversion_output":true,"text":"without the illness in question (sensitivity and specificity). Alternatively the validity of a test can be","text_display":" without the illness in question (sensitivity and specificity). Alternatively the validity of a test can be","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1876,1042],[1876,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1632,"height":49},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7f6be3fbd2b4fc19487160249037b49","type":"text","conversion_output":true,"text":"measured by how well the test results predict the presence or absence of the disease (PPV and NPV).","text_display":" measured by how well the test results predict the presence or absence of the disease (PPV and NPV).","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1880,1087],[1880,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce3dd11f3c7743d281399d3f97dc3151","type":"text","conversion_output":true,"text":"Collectively, sensitivity, specificity, PPV, and NPV are often referred to as the test's operating","text_display":" Collectively, sensitivity, specificity, PPV, and NPV are often referred to as the test's operating","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1878,1130],[1878,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1634,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dee9930fd1be473a92a669da2c79878b","type":"text","conversion_output":true,"text":"characteristics with the sensitivity and NPV being the most clinically relevant parameters for this study.","text_display":" characteristics with the sensitivity and NPV being the most clinically relevant parameters for this study.","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1880,1173],[1880,1220],[245,1220]],"region":{"top_left_x":244,"top_left_y":1173,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf6f448ed7b34bbb9f24cd16e64d08b8","type":"text","conversion_output":true,"text":"Each component of the operating characteristics will be calculated based first on the entire cohort. As","text_display":" Each component of the operating characteristics will be calculated based first on the entire cohort. As","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1880,1216],[1880,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1636,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59d07b3227dc4d0197ee5b452be85cab","type":"text","conversion_output":true,"text":"indicated in the sample size estimates above the incidence of IFI will vary between the two study arms. It","text_display":" indicated in the sample size estimates above the incidence of IFI will vary between the two study arms. It","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1880,1263],[1880,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1263,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"626f7e2ba40f489c80ffe106edc707b0","type":"text","conversion_output":true,"text":"is well documented that variations in the incidence/prevalence of a disease will impact the operating","text_display":" is well documented that variations in the incidence/prevalence of a disease will impact the operating","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1878,1306],[1878,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1634,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ef7d3f475934906b0422e4aa9cc3177","type":"text","conversion_output":true,"text":"characteristics of a diagnostic test specifically for the PPV and NPV. Therefore, each assay's sensitivity,","text_display":" characteristics of a diagnostic test specifically for the PPV and NPV. Therefore, each assay's sensitivity,","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1470,1349],[1470,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1349,"width":1226,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a1e937da82f45159f61cd77c4f18333","type":"text","conversion_output":true,"text":"specificity, PPV and NPV will also be calculated separately for each study arm.","text_display":" specificity, PPV and NPV will also be calculated separately for each study arm.","confidence":1,"confidence_rate":1},{"cnt":[[245,1422],[1880,1422],[1880,1472],[245,1472]],"region":{"top_left_x":244,"top_left_y":1422,"width":1636,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"623c422080844549860a64b97846fb10","type":"text","conversion_output":true,"text":"The operating characteristics for both the Platelia Aspergillus EIA and the Fungitell Assay will be","text_display":"\n\nThe operating characteristics for both the Platelia Aspergillus EIA and the Fungitell Assay will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1470],[1248,1470],[1248,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1469,"width":1005,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c0d1dc8784647f09bb784192cac7194","type":"text","conversion_output":true,"text":"computed at the patient level for each of the sub-aims as follows:","text_display":" computed at the patient level for each of the sub-aims as follows:","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1880,1543],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c78eb6aea2804b6ba70dfbe641312b6c","type":"text","conversion_output":true,"text":"a) Outcome of IA only or all IFI defined as a single positive test for either the Platelia Aspergillus","text_display":"\na) Outcome of IA only or all IFI defined as a single positive test for either the Platelia Aspergillus","confidence":1,"confidence_rate":1},{"cnt":[[370,1590],[1880,1590],[1880,1635],[370,1635]],"region":{"top_left_x":369,"top_left_y":1589,"width":1511,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69764c83b1d448fe97591efe9fa12cb8","type":"text","conversion_output":true,"text":"EIA or the Fungitell Assay as compared to the EORTC/MSG criteria for proven or probable IA","text_display":" EIA or the Fungitell Assay as compared to the EORTC/MSG criteria for proven or probable IA","confidence":1,"confidence_rate":1},{"cnt":[[370,1633],[604,1633],[604,1678],[370,1678]],"region":{"top_left_x":369,"top_left_y":1632,"width":235,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63f306dce28f460885b6c4d14df0ec9a","type":"text","conversion_output":true,"text":"only or all IFI.","text_display":" only or all IFI.","confidence":1,"confidence_rate":1},{"cnt":[[245,1708],[1880,1708],[1880,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1708,"width":1636,"height":48},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6cae3e4a0f343cc80c1622f783ac051","type":"text","conversion_output":true,"text":"b) Outcome of IA only defined as a single positive test for Platelia Aspergillus EIA only as","text_display":"\nb) Outcome of IA only defined as a single positive test for Platelia Aspergillus EIA only as","confidence":1,"confidence_rate":1},{"cnt":[[370,1753],[1459,1753],[1459,1800],[370,1800]],"region":{"top_left_x":369,"top_left_y":1753,"width":1090,"height":48},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f483ceeee54c483ea1e7d3f13c5e0409","type":"text","conversion_output":true,"text":"compared to the EORTC/MSG criteria for proven or probable IA only.","text_display":" compared to the EORTC/MSG criteria for proven or probable IA only.","confidence":1,"confidence_rate":1},{"cnt":[[245,1828],[1880,1828],[1880,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1828,"width":1636,"height":48},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba3b4816e5b0460eb20f9b214181ced8","type":"text","conversion_output":true,"text":"c) Outcome of all IFI defined as a single positive test for the Fungitell Assay as compared to the","text_display":"\nc) Outcome of all IFI defined as a single positive test for the Fungitell Assay as compared to the","confidence":1,"confidence_rate":1},{"cnt":[[370,1873],[1179,1873],[1179,1919],[370,1919]],"region":{"top_left_x":369,"top_left_y":1873,"width":811,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55322a0daf084e66ae1d7fcc5ff774aa","type":"text","conversion_output":true,"text":"EORTC/MSG criteria for all proven or probable IFI.","text_display":" EORTC/MSG criteria for all proven or probable IFI.","confidence":1,"confidence_rate":1},{"cnt":[[245,1959],[1880,1959],[1880,2007],[245,2007]],"region":{"top_left_x":244,"top_left_y":1959,"width":1636,"height":48},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7284078faa984eea80468932ba1698e0","type":"text","conversion_output":true,"text":"Sensitivity, specificity, PPV and NPV and their accompanying \\(95 \\%\\) confidence intervals will be","text_display":"\n\nSensitivity, specificity, PPV and NPV and their accompanying \\(95 \\%\\) confidence intervals will be","confidence":0.99658203125,"confidence_rate":0.9999661013334881},{"cnt":[[245,2004],[1880,2004],[1880,2052],[245,2052]],"region":{"top_left_x":244,"top_left_y":2004,"width":1636,"height":48},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6128312b7a6a40ca9e36d904a8463efd","type":"text","conversion_output":true,"text":"calculated using STATA statistical software version 11.0 (College Station, TX). As noted above, these","text_display":" calculated using STATA statistical software version 11.0 (College Station, TX). As noted above, these","confidence":1,"confidence_rate":1},{"cnt":[[245,2050],[1880,2050],[1880,2095],[245,2095]],"region":{"top_left_x":244,"top_left_y":2049,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"909f8c2f94e644b9b191290921788488","type":"text","conversion_output":true,"text":"parameters will first be calculated for the entire cohort and then for each study arm separately. The latter","text_display":" parameters will first be calculated for the entire cohort and then for each study arm separately. The latter","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1882,2093],[1882,2138],[245,2138]],"region":{"top_left_x":244,"top_left_y":2092,"width":1639,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1d5ed3e35e94b94be13456ff9bd0af3","type":"text","conversion_output":true,"text":"analyses are important as the incidence of IFI may vary by study arm thus impacting the interpretation of","text_display":" analyses are important as the incidence of IFI may vary by study arm thus impacting the interpretation of","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[1880,2136],[1880,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2135,"width":1636,"height":50},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2fd8e4639ab481a91372a61c0f16f59","type":"text","conversion_output":true,"text":"the assay results. A patient with multiple episodes of IFI will only be included in the analyses as a single","text_display":" the assay results. A patient with multiple episodes of IFI will only be included in the analyses as a single","confidence":0.9975600242614746,"confidence_rate":0.9999783811422721},{"cnt":[[245,2179],[314,2179],[314,2221],[245,2221]],"region":{"top_left_x":244,"top_left_y":2178,"width":70,"height":44},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d824069536a345a3b2d21c51304b2c7a","type":"text","conversion_output":true,"text":"IFI.","text_display":" IFI.","confidence":1,"confidence_rate":1},{"cnt":[[245,2264],[1003,2264],[1003,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2264,"width":760,"height":55},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02532d3430bb4ee0a52082c14d2684a2","type":"section_header","conversion_output":false,"children_ids":["4108ead865314fa6ae8a43a1db4dd9a3"],"text":"","text_display":""},{"cnt":[[249,2269],[999,2269],[999,2314],[249,2314]],"region":{"top_left_x":249,"top_left_y":2268,"width":751,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4108ead865314fa6ae8a43a1db4dd9a3","type":"text","conversion_output":true,"parent_id":"02532d3430bb4ee0a52082c14d2684a2","text":"13.8.3 Receiver Operator Characteristics Curve","text_display":"\n\n\\subsection*{13.8.3 Receiver Operator Characteristics Curve}","confidence":0.9970722198486328,"confidence_rate":0.9999425099960718},{"cnt":[[245,2312],[1878,2312],[1878,2359],[245,2359]],"region":{"top_left_x":244,"top_left_y":2311,"width":1634,"height":48},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74bf444d340d46838018c606a0240c6d","type":"text","conversion_output":true,"text":"In addition to understanding the operating characteristics of a diagnostic test at a single defined threshold,","text_display":"\n\nIn addition to understanding the operating characteristics of a diagnostic test at a single defined threshold,","confidence":1,"confidence_rate":1},{"cnt":[[245,2357],[1880,2357],[1880,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2356,"width":1636,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ef6b925aee04a60a7aeda8120faaefa","type":"text","conversion_output":true,"text":"it is also important to understand how variations in the test's threshold can alter the test's operating","text_display":" it is also important to understand how variations in the test's threshold can alter the test's operating","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1880,2402],[1880,2447],[245,2447]],"region":{"top_left_x":244,"top_left_y":2401,"width":1636,"height":47},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b5d152fb55046e8b629ade2e089ef32","type":"text","conversion_output":true,"text":"characteristics. The receiver operating characteristics (ROC) curve is a useful approach to illustrate how","text_display":" characteristics. The receiver operating characteristics (ROC) curve is a useful approach to illustrate how","confidence":1,"confidence_rate":1},{"cnt":[[245,2445],[1880,2445],[1880,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2444,"width":1636,"height":51},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c11de4a0e99e40a7ae6ff155681eda12","type":"text","conversion_output":true,"text":"these operating characteristics will change as the threshold changes. Therefore, a receiver-operating-","text_display":" these operating characteristics will change as the threshold changes. Therefore, a receiver-operating-","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[612,2582],[612,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":369,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d21183ccec744b4b59948cc4649f48a","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1876,2582],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":128,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3acb96bb9c5847be9a0207c38105ed0d","type":"page_info","conversion_output":false,"text":"Page 48","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"30d0fca4-08d7-48bb-b63f-1324b67d52fd-49","page":49,"lines":[{"cnt":[[262,88],[436,88],[436,122],[262,122]],"region":{"top_left_x":262,"top_left_y":88,"width":175,"height":35},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c368aafe5cea471790d30ce687c4e890","type":"page_info","conversion_output":false,"text":"CHILDREN'S","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,120],[417,120],[417,157],[262,157]],"region":{"top_left_x":262,"top_left_y":120,"width":155,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"200d74eac77c403bbb33ff34159341e4","type":"page_info","conversion_output":false,"text":"ONCOLOGY","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[494,129],[1497,129],[1497,170],[494,170]],"region":{"top_left_x":494,"top_left_y":128,"width":1004,"height":42},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2ea1281900d242e2b3c471359eab4e98","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.9761475823079309,"confidence_rate":0.999698276869841},{"cnt":[[1691,125],[1880,125],[1880,168],[1691,168]],"region":{"top_left_x":1690,"top_left_y":124,"width":190,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"841cdcacca944b6497de2da5af10991f","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[365,155],[365,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":104,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d9da580e349f4e0c8070c78695beae6f","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1882,249],[1882,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1639,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c603be8200345cd901508955e4f022c","type":"text","conversion_output":true,"text":"characteristics (ROC) curve will be generated with a series of sensitivities and specificities derived from","text_display":"\ncharacteristics (ROC) curve will be generated with a series of sensitivities and specificities derived from","confidence":1,"confidence_rate":1},{"cnt":[[245,294],[1880,294],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":294,"width":1636,"height":48},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0df213b89a1f40afa16613335fa51137","type":"text","conversion_output":true,"text":"various cutoff values. For the Platelia Aspergillus EIA cutoffs of \\(>0.5,1.0,1.5\\) and 2.0 will be used. For","text_display":" various cutoff values. For the Platelia Aspergillus EIA cutoffs of \\(>0.5,1.0,1.5\\) and 2.0 will be used. For","confidence":0.9951229095458984,"confidence_rate":0.9999578541444495},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac0ceaa70c554901813e39006614011f","type":"text","conversion_output":true,"text":"the Fungitell Assay cutoffs of \\(\\geq 40, \\geq 60, \\geq 80\\), and \\(\\geq 100 pg / mL\\) will be used to create the ROC. The","text_display":" the Fungitell Assay cutoffs of \\(\\geq 40, \\geq 60, \\geq 80\\), and \\(\\geq 100 pg / mL\\) will be used to create the ROC. The","confidence":0.9785711544100195,"confidence_rate":0.9998048678970867},{"cnt":[[245,382],[1880,382],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1636,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5acd9d8d04d42489882897b870256c9","type":"text","conversion_output":true,"text":"ROC curve will be displayed graphically (sensitivity vs. 1-specificity) and evaluated numerically","text_display":" ROC curve will be displayed graphically (sensitivity vs. 1-specificity) and evaluated numerically","confidence":0.92822265625,"confidence_rate":0.9992700347536595},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28b80dfe61c241fb8ae0b78dbd9c8d00","type":"text","conversion_output":true,"text":"(c-statistic). The c-statistic (also referred to as the area under the curve (AUC)) varies from 0.5 to 1.0 and","text_display":" (c-statistic). The c-statistic (also referred to as the area under the curve (AUC)) varies from 0.5 to 1.0 and","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1880,471],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1636,"height":48},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10ed544d8f794a9fb8bb83fe777b29bd","type":"text","conversion_output":true,"text":"is a measure of the test's ability to discriminate between patients with and without the gold standard","text_display":" is a measure of the test's ability to discriminate between patients with and without the gold standard","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1880,511],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1636,"height":50},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a57a0cf1dadc43f4a58b7829b5479fee","type":"text","conversion_output":true,"text":"diagnosis. \\({ }^{72}\\) A c-statistic of 0.5 is possible by chance alone while a perfectly discriminating test will result","text_display":" diagnosis. \\({ }^{72}\\) A c-statistic of 0.5 is possible by chance alone while a perfectly discriminating test will result","confidence":0.9980480668600649,"confidence_rate":0.9999849705695273},{"cnt":[[245,559],[574,559],[574,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":330,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a38fc63e34c45f4b7c82f825e19d2c6","type":"text","conversion_output":true,"text":"in a c-statistic of 1.0.","text_display":" in a c-statistic of 1.0.","confidence":0.6823282241821289,"confidence_rate":0.9869056431287022},{"cnt":[[245,645],[1880,645],[1880,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1636,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f0b2f9fadbd426592a330a8663f512c","type":"text","conversion_output":true,"text":"Additionally, the ROC curves will be used in an exploratory analysis to identify the threshold for each","text_display":"\n\nAdditionally, the ROC curves will be used in an exploratory analysis to identify the threshold for each","confidence":1,"confidence_rate":1},{"cnt":[[245,690],[1880,690],[1880,737],[245,737]],"region":{"top_left_x":244,"top_left_y":689,"width":1636,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3d07066c6cd4339891b3d680755d4fd","type":"text","conversion_output":true,"text":"biomarker assay that optimizes the diagnostic test's sensitivity while maintaining a reasonable specificity.","text_display":" biomarker assay that optimizes the diagnostic test's sensitivity while maintaining a reasonable specificity.","confidence":0.98779296875,"confidence_rate":0.9998913143227193},{"cnt":[[245,735],[1880,735],[1880,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60eb509867fd423ba91deb4646d4b447","type":"text","conversion_output":true,"text":"The identified thresholds will be used to categorize each patient as \"likely to have IFI or IA\" and \"not","text_display":" The identified thresholds will be used to categorize each patient as \"likely to have IFI or IA\" and \"not","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1880,778],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1636,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"499f28fa2e484cb38d0c498cffc644f1","type":"text","conversion_output":true,"text":"likely to have IFI or IA\". Once these 2 sub-groups are defined we will calculate the incidence rates of IFI","text_display":" likely to have IFI or IA\". Once these 2 sub-groups are defined we will calculate the incidence rates of IFI","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1880,821],[1880,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1636,"height":51},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"498ba160b9a24bde87022b7de9bcfc93","type":"text","conversion_output":true,"text":"or IA for each sub-group and compare them. Because the anticipated incidence for IFI and IA may be","text_display":" or IA for each sub-group and compare them. Because the anticipated incidence for IFI and IA may be","confidence":1,"confidence_rate":1},{"cnt":[[245,866],[1880,866],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":865,"width":1636,"height":49},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83ce3ff087a44f88a7242ab7219aff57","type":"text","conversion_output":true,"text":"variable between the two study arms (those receiving fluconazole and those receiving caspofungin) this","text_display":" variable between the two study arms (those receiving fluconazole and those receiving caspofungin) this","confidence":1,"confidence_rate":1},{"cnt":[[245,907],[1880,907],[1880,956],[245,956]],"region":{"top_left_x":244,"top_left_y":906,"width":1636,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b165563f84df413f8569747119b7fc11","type":"text","conversion_output":true,"text":"approach will have to be done at the level of each study arm. The incidence rates will be compared","text_display":" approach will have to be done at the level of each study arm. The incidence rates will be compared","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[999,954],[999,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":953,"width":756,"height":51},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"046597dc316b46d3b9290ba3a4f92a35","type":"text","conversion_output":true,"text":"statistically using Pearson's Chi-square analysis.","text_display":" statistically using Pearson's Chi-square analysis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1040],[1880,1040],[1880,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1039,"width":1636,"height":51},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a944b49547c6441bb1ed521283ed56d5","type":"text","conversion_output":true,"text":"Finally, to further explore the ideal utility and interpretation of each biomarker, serial testing results will","text_display":"\n\nFinally, to further explore the ideal utility and interpretation of each biomarker, serial testing results will","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1880,1087],[1880,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4d20eac585c4ad7a45598e3d2b082bc","type":"text","conversion_output":true,"text":"be explored. For this analysis the Platelia Aspergillus EIA will be considered positive when a patient has","text_display":" be explored. For this analysis the Platelia Aspergillus EIA will be considered positive when a patient has","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1880,1130],[1880,1177],[245,1177]],"region":{"top_left_x":244,"top_left_y":1130,"width":1636,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"622f08178ef24ee9930fd20adce0a6e1","type":"text","conversion_output":true,"text":"2 consecutive tests \\(>0.5\\) GM index and the Fungitell Assay will be considered positive when a patient has","text_display":" 2 consecutive tests \\(>0.5\\) GM index and the Fungitell Assay will be considered positive when a patient has","confidence":0.55419921875,"confidence_rate":0.994696715427114},{"cnt":[[245,1173],[1880,1173],[1880,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1636,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c3cefe8ec254b8b91d415927125d25b","type":"text","conversion_output":true,"text":"2 consecutive test results \\(\\geq 80 pg / mL\\). Operating characteristics and ROC curves will be constructed in a","text_display":" 2 consecutive test results \\(\\geq 80 pg / mL\\). Operating characteristics and ROC curves will be constructed in a","confidence":0.9990234375,"confidence_rate":0.9999915772798866},{"cnt":[[245,1216],[793,1216],[793,1261],[245,1261]],"region":{"top_left_x":244,"top_left_y":1216,"width":549,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba22efcc15ae4689b0b99750bc831e8f","type":"text","conversion_output":true,"text":"similar manner as discussed above.","text_display":" similar manner as discussed above.","confidence":1,"confidence_rate":1},{"cnt":[[241,1300],[694,1300],[694,1356],[241,1356]],"region":{"top_left_x":240,"top_left_y":1299,"width":454,"height":57},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c43d0d5b81941a0ab0b7a8be893e1f3","type":"section_header","conversion_output":false,"children_ids":["9d31b0ca09a9499bba000db77befa4f2"],"text":"","text_display":""},{"cnt":[[247,1306],[690,1306],[690,1351],[247,1351]],"region":{"top_left_x":247,"top_left_y":1306,"width":443,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d31b0ca09a9499bba000db77befa4f2","type":"text","conversion_output":true,"parent_id":"4c43d0d5b81941a0ab0b7a8be893e1f3","text":"13.8.4 Sensitivity Analysis","text_display":"\n\n\\subsection*{13.8.4 Sensitivity Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1880,1349],[1880,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1349,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c6acce6600a40339ca82f210fe21894","type":"text","conversion_output":true,"text":"Sensitivity analyses will be explored for reasoning expressed in both Sections 13.1 and 13.7 above. The","text_display":"\n\nSensitivity analyses will be explored for reasoning expressed in both Sections 13.1 and 13.7 above. The","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,1392],[1880,1392],[1880,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1636,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0c22e270702448889bb52b7ab1aa312","type":"text","conversion_output":true,"text":"first sensitivity analysis will attempt to identify the direction and magnitude of the bias resulting from the","text_display":" first sensitivity analysis will attempt to identify the direction and magnitude of the bias resulting from the","confidence":1,"confidence_rate":1},{"cnt":[[245,1435],[1880,1435],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1435,"width":1636,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7f784aa599e41eeb753577022a63113","type":"text","conversion_output":true,"text":"availability of clinical BG and GM testing outside of the ancillary study. Such testing has the potential to","text_display":" availability of clinical BG and GM testing outside of the ancillary study. Such testing has the potential to","confidence":0.9990234375,"confidence_rate":0.9999913536688149},{"cnt":[[245,1482],[1880,1482],[1880,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1482,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e8b5464784a4868a95349e11f2f2025","type":"text","conversion_output":true,"text":"change the treating clinician's approach for diagnosing an IFI. It is possible that these test results could","text_display":" change the treating clinician's approach for diagnosing an IFI. It is possible that these test results could","confidence":0.998046875,"confidence_rate":0.9999826989564276},{"cnt":[[245,1525],[1880,1525],[1880,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1636,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9805071b2424a6f96f51ed834cccf63","type":"text","conversion_output":true,"text":"result in more or less investigation (i.e., radiologic imaging) to identify an IFI which could ultimately","text_display":" result in more or less investigation (i.e., radiologic imaging) to identify an IFI which could ultimately","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1880,1568],[1880,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1636,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97fd502053cf425b9c16572a36da17fd","type":"text","conversion_output":true,"text":"impact on the incidence of identified IFI. Therefore, in addition to calculating the operating characteristics","text_display":" impact on the incidence of identified IFI. Therefore, in addition to calculating the operating characteristics","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1880,1611],[1880,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1636,"height":50},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e51639281324f8087511a674240be56","type":"text","conversion_output":true,"text":"for all patients enrolled as described in Section 13.8.2 above, the same operating characteristics will be","text_display":" for all patients enrolled as described in Section 13.8.2 above, the same operating characteristics will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1880,1659],[1880,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f51a12f71dbb457ebe9063ceec9cb922","type":"text","conversion_output":true,"text":"calculated after excluding all patients that had at least 1 biomarker test result available to the treating","text_display":" calculated after excluding all patients that had at least 1 biomarker test result available to the treating","confidence":1,"confidence_rate":1},{"cnt":[[245,1697],[397,1697],[397,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1697,"width":154,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91f1f72fc9a2466c85c383ab045317f2","type":"text","conversion_output":true,"text":"clinician.","text_display":" clinician.","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1880,1788],[1880,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1636,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cb4eb68642a4666a3e0e94011cb80a5","type":"text","conversion_output":true,"text":"The second sensitivity analysis will be performed to explore the impact of the various factors described in","text_display":"\n\nThe second sensitivity analysis will be performed to explore the impact of the various factors described in","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[1880,1830],[1880,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1830,"width":1636,"height":50},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"354a6944050c476eacd37b2ef6ff66a6","type":"text","conversion_output":true,"text":"Section 13.7 that may contribute to a positive result for either biomarker. False positive results would","text_display":" Section 13.7 that may contribute to a positive result for either biomarker. False positive results would","confidence":1,"confidence_rate":1},{"cnt":[[245,1876],[1880,1876],[1880,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1875,"width":1636,"height":48},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"553608fbac4d4753980c9a50ded7989f","type":"text","conversion_output":true,"text":"impact the final interpretation of sensitivity and PPV for each of the assays. However, it is also possible","text_display":" impact the final interpretation of sensitivity and PPV for each of the assays. However, it is also possible","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1880,1921],[1880,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc13cc9dbbb04d72a39c9ce54f577889","type":"text","conversion_output":true,"text":"that one of the factors listed in Table 3 is present in a patient that truly has an IFI. Therefore, we plan to","text_display":" that one of the factors listed in Table 3 is present in a patient that truly has an IFI. Therefore, we plan to","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[245,1964],[1880,1964],[1880,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1963,"width":1636,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b05d411efb38428db729d9a7092052ba","type":"text","conversion_output":true,"text":"still include all patients in the primary analysis for calculation of each assays' operating characteristics. In","text_display":" still include all patients in the primary analysis for calculation of each assays' operating characteristics. In","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1880,2007],[1880,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1636,"height":51},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c387a7d039fd4ba580006d384d1b26dd","type":"text","conversion_output":true,"text":"this sensitivity analysis, we will eliminate all patients with a positive test that correlates in time with at","text_display":" this sensitivity analysis, we will eliminate all patients with a positive test that correlates in time with at","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,2052],[831,2052],[831,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2051,"width":588,"height":49},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b17ce7cf3d44b0eb6bad5261ba79434","type":"text","conversion_output":true,"text":"least 1 of the factors listed in Table 3.","text_display":" least 1 of the factors listed in Table 3.","confidence":1,"confidence_rate":1},{"cnt":[[241,2136],[582,2136],[582,2194],[241,2194]],"region":{"top_left_x":240,"top_left_y":2135,"width":343,"height":59},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29b1de418e4641e1a465b86a3ec3dc93","type":"section_header","conversion_output":false,"children_ids":["170f051753334fb69122ed6dc690c2fc"],"text":"","text_display":""},{"cnt":[[247,2140],[578,2140],[578,2185],[247,2185]],"region":{"top_left_x":247,"top_left_y":2139,"width":331,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"170f051753334fb69122ed6dc690c2fc","type":"text","conversion_output":true,"parent_id":"29b1de418e4641e1a465b86a3ec3dc93","text":"13.9 Significance","text_display":"\n\n\\subsection*{13.9 Significance}","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1880,2183],[1880,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2182,"width":1636,"height":49},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6e04ee0ffd64ab9b5f043bec99ad431","type":"text","conversion_output":true,"text":"Fungal infections continue to be major contributors to morbidity and mortality in children receiving","text_display":"\n\nFungal infections continue to be major contributors to morbidity and mortality in children receiving","confidence":0.9990234375,"confidence_rate":0.9999906949037896},{"cnt":[[245,2228],[1882,2228],[1882,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2227,"width":1639,"height":49},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29425d20915a47aeab6ced0e80e13d21","type":"text","conversion_output":true,"text":"chemotherapy for AML. Although antifungal prophylaxis in these patients will reduce the frequency of","text_display":" chemotherapy for AML. Although antifungal prophylaxis in these patients will reduce the frequency of","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1880,2273],[1880,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"408e6c09e48a49a6ba04886c6495962c","type":"text","conversion_output":true,"text":"IFI, it will not eliminate the risk of these devastating infections. Early diagnosis and therapeutic","text_display":" IFI, it will not eliminate the risk of these devastating infections. Early diagnosis and therapeutic","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1880,2316],[1880,2363],[245,2363]],"region":{"top_left_x":244,"top_left_y":2316,"width":1636,"height":48},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e90300ba607a414c87c10546b8aff64a","type":"text","conversion_output":true,"text":"modifications are paramount to improving patient outcomes. The Platelia Aspergillus EIA and the","text_display":" modifications are paramount to improving patient outcomes. The Platelia Aspergillus EIA and the","confidence":1,"confidence_rate":1},{"cnt":[[245,2359],[1880,2359],[1880,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2358,"width":1636,"height":51},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a34f1d6089224efb9ac0be94d5d0fce7","type":"text","conversion_output":true,"text":"Fungitell Assay are potential diagnostic tools that could improve the time to diagnosis of IFIs. More","text_display":" Fungitell Assay are potential diagnostic tools that could improve the time to diagnosis of IFIs. More","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1880,2402],[1880,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1636,"height":51},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0a52eb70f444ca7bb0fefdef62ca5d2","type":"text","conversion_output":true,"text":"definitive data regarding the operating characteristics of these 2 biomarkers interpreted simultaneously","text_display":" definitive data regarding the operating characteristics of these 2 biomarkers interpreted simultaneously","confidence":1,"confidence_rate":1},{"cnt":[[245,2449],[1880,2449],[1880,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2449,"width":1636,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d559b3355234a1ead93ebca039dba11","type":"text","conversion_output":true,"text":"and separately in the setting of a large pediatric cohort receiving fungal prophylaxis are necessary.","text_display":" and separately in the setting of a large pediatric cohort receiving fungal prophylaxis are necessary.","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[614,2582],[614,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2582,"width":371,"height":42},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12e5d5120d884cc3a4802b1f511b93ce","type":"page_info","conversion_output":false,"text":"Version Date: 04/22/14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1880,2582],[1880,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":132,"height":46},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be5c1ae6398341aebb697a424b6c1d4f","type":"page_info","conversion_output":false,"text":"Page 49","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"30d0fca4-08d7-48bb-b63f-1324b67d52fd-50","page":50,"lines":[{"cnt":[[262,86],[436,86],[436,122],[262,122]],"region":{"top_left_x":262,"top_left_y":85,"width":175,"height":38},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7a9b1d03a1ec47cabe150872eeb5c80d","type":"page_info","conversion_output":false,"text":"CHILDREN'S","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[262,120],[417,120],[417,157],[262,157]],"region":{"top_left_x":262,"top_left_y":120,"width":155,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e1378df995774deea2df6f89a57f1519","type":"page_info","conversion_output":false,"text":"ONCOLOGY","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[494,129],[1497,129],[1497,170],[494,170]],"region":{"top_left_x":494,"top_left_y":128,"width":1004,"height":42},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"046d922a97814f5c8f171de4195b468b","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.9761475823079309,"confidence_rate":0.999698276869841},{"cnt":[[1689,125],[1880,125],[1880,168],[1689,168]],"region":{"top_left_x":1688,"top_left_y":124,"width":192,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db29df5e62374978b0383cfc50a48a03","type":"page_info","conversion_output":false,"text":"ACCL0933","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[262,155],[367,155],[367,191],[262,191]],"region":{"top_left_x":262,"top_left_y":154,"width":106,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c17a66c99e654baf8588855ade7390c6","type":"page_info","conversion_output":false,"text":"GROUP","text_display":"","confidence":0.99755859375,"confidence_rate":0.9997555907386334},{"cnt":[[245,249],[1880,249],[1880,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1636,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ee47e27e2cd400db4c6d1352bac6d21","type":"text","conversion_output":true,"text":"Evaluating the biomarkers first as integrated tests will provide valuable information regarding the utility","text_display":"\n\nEvaluating the biomarkers first as integrated tests will provide valuable information regarding the utility","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4559ef17828c4e4f8f9f164a5cd53f11","type":"text","conversion_output":true,"text":"of each test so that they can be utilized as integral markers in future pediatric cancer trials. Finally,","text_display":" of each test so that they can be utilized as integral markers in future pediatric cancer trials. Finally,","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26dcc7acc5834d77a9b959395b0b254b","type":"text","conversion_output":true,"text":"specimens from this study will be stored for potential future investigation. This will allow for the","text_display":" specimens from this study will be stored for potential future investigation. 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Include a COG Specimen Transmittal Form with shipment.","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[1725,1667],[1725,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1667,"width":1482,"height":50},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0dd158a347b4446ab1734afda3dd546d","type":"text","conversion_output":true,"text":"The SNP sample (for patients not enrolled on AAML1031) should be shipped to the address below.","text_display":"\nThe SNP sample (for patients not enrolled on AAML1031) should be shipped to the address below.","confidence":1,"confidence_rate":1},{"cnt":[[748,1714],[1283,1714],[1283,2088],[748,2088]],"region":{"top_left_x":747,"top_left_y":1714,"width":536,"height":375},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae4d80d63fd4447da3baeae0dc129f5a","type":"math","conversion_output":true,"text":"\\[\n\\begin{aligned}\n& \\text { Richard Aplenc, MD, PhD } \\\\\n& \\text { Pediatric Oncology } \\\\\n& \\text { 4018 CTRB } \\\\\n& \\text { 3501 Civic Center Blvd } \\\\\n& \\text { Philadelphia, PA 19104-4318 } \\\\\n& \\text { Phone: (267) 426-7252 } \\\\\n& \\text { Fax: (267) 425-0113 } \\\\\n& \\text { E-mail: Aplenc@email.chop.edu }\n\\end{aligned}\n\\]","text_display":"\n\\[\n\\begin{aligned}\n& \\text { Richard Aplenc, MD, PhD } \\\\\n& \\text { Pediatric Oncology } \\\\\n& \\text { 4018 CTRB } \\\\\n& \\text { 3501 Civic Center Blvd } \\\\\n& \\text { Philadelphia, PA 19104-4318 } \\\\\n& \\text { Phone: (267) 426-7252 } \\\\\n& \\text { Fax: (267) 425-0113 } \\\\\n& \\text { E-mail: Aplenc@email.chop.edu 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With","confidence":1,"confidence_rate":1},{"cnt":[[855,529],[1265,529],[1265,574],[855,574]],"region":{"top_left_x":855,"top_left_y":528,"width":411,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0aa5d6f1bb9e48ad83b5ad19be603940","type":"text","conversion_output":true,"parent_id":"d91daa1abafa4cd7b593b3951a7032f4","text":"Acute Myeloid Leukemia.","text_display":" Acute Myeloid Leukemia.}","confidence":1,"confidence_rate":1},{"cnt":[[309,614],[1878,614],[1878,662],[309,662]],"region":{"top_left_x":309,"top_left_y":614,"width":1569,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8be829617c3a42aca3cc618babfe20a1","type":"text","conversion_output":true,"text":"1. We have been talking with you about your likelihood of getting Invasive Fungal Infections.","text_display":"\n1. 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The strong cancer fighting drugs (called","text_display":" ability (also called immunity) have been reduced. The strong cancer fighting drugs (called","confidence":1,"confidence_rate":1},{"cnt":[[370,748],[1880,748],[1880,793],[370,793]],"region":{"top_left_x":369,"top_left_y":747,"width":1511,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"170bc4c54032496386ceafac796051a3","type":"text","conversion_output":true,"text":"chemotherapy) used to treat your acute myeloid leukemia (AML) reduce your immunity and","text_display":" chemotherapy) used to treat your acute myeloid leukemia (AML) reduce your immunity and","confidence":1,"confidence_rate":1},{"cnt":[[370,791],[1132,791],[1132,836],[370,836]],"region":{"top_left_x":369,"top_left_y":790,"width":764,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64182d68483642f881fe5039b63a2140","type":"text","conversion_output":true,"text":"make you likely to get invasive fungal infections.","text_display":" make you likely to get invasive fungal infections.","confidence":0.99853515625,"confidence_rate":0.9999733473064166},{"cnt":[[305,881],[1878,881],[1878,926],[305,926]],"region":{"top_left_x":305,"top_left_y":880,"width":1573,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51893b72f544473c8b20bd0b0dc437ef","type":"text","conversion_output":true,"text":"2. We are asking you to take part in a research study because you are at risk of invasive fungal","text_display":"\n2. We are asking you to take part in a research study because you are at risk of invasive fungal","confidence":1,"confidence_rate":1},{"cnt":[[370,924],[1880,924],[1880,969],[370,969]],"region":{"top_left_x":369,"top_left_y":923,"width":1511,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a8486ca81864e7b847a70b140937e24","type":"text","conversion_output":true,"text":"infections. A research study is when doctors work together to try out new ways to help people","text_display":" infections. A research study is when doctors work together to try out new ways to help people","confidence":1,"confidence_rate":1},{"cnt":[[370,967],[1880,967],[1880,1012],[370,1012]],"region":{"top_left_x":369,"top_left_y":966,"width":1511,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"483e7cf8f7cd4129b66ffb2ee386aacb","type":"text","conversion_output":true,"text":"who are sick. In this study, we are trying to find better ways to prevent invasive fungal infections","text_display":" who are sick. In this study, we are trying to find better ways to prevent invasive fungal infections","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[370,1010],[900,1010],[900,1051],[370,1051]],"region":{"top_left_x":369,"top_left_y":1009,"width":532,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b49760a37ff848458fffc76b45ddc76b","type":"text","conversion_output":true,"text":"in children on treatment for AML.","text_display":" in children on treatment for AML.","confidence":1,"confidence_rate":1},{"cnt":[[305,1096],[1880,1096],[1880,1145],[305,1145]],"region":{"top_left_x":305,"top_left_y":1095,"width":1575,"height":51},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7dfc8788d14341d9abf93611ee2eb43e","type":"text","conversion_output":true,"text":"3. Children who are part of this study will be given medicines that help prevent invasive fungal","text_display":"\n3. Children who are part of this study will be given medicines that help prevent invasive fungal","confidence":1,"confidence_rate":1},{"cnt":[[370,1143],[1880,1143],[1880,1188],[370,1188]],"region":{"top_left_x":369,"top_left_y":1142,"width":1511,"height":47},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1165cb4cf50745cf981d1715291ae688","type":"text","conversion_output":true,"text":"infections. These drugs are called antifungal agents. In this study, one group of children will get","text_display":" infections. These drugs are called antifungal agents. In this study, one group of children will get","confidence":1,"confidence_rate":1},{"cnt":[[370,1186],[1880,1186],[1880,1231],[370,1231]],"region":{"top_left_x":369,"top_left_y":1185,"width":1511,"height":47},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62976b9432da4682a85d444241071b7d","type":"text","conversion_output":true,"text":"the usual antifungal drug called fluconazole. The other group will get a newer antifungal agent","text_display":" the usual antifungal drug called fluconazole. The other group will get a newer antifungal agent","confidence":1,"confidence_rate":1},{"cnt":[[370,1231],[1878,1231],[1878,1276],[370,1276]],"region":{"top_left_x":369,"top_left_y":1231,"width":1509,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c55bc9226df411bb15e677efebb7517","type":"text","conversion_output":true,"text":"called caspofungin. Your doctor will tell you which group you are in. 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These good","confidence":1,"confidence_rate":1},{"cnt":[[370,1452],[1880,1452],[1880,1497],[370,1497]],"region":{"top_left_x":369,"top_left_y":1452,"width":1511,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a3be4ef73ed4598be12d634077ba5dd","type":"text","conversion_output":true,"text":"things are called \"benefits.\" We hope that a benefit to you of being part of this study is a better","text_display":" things are called \"benefits.\" We hope that a benefit to you of being part of this study is a better","confidence":1,"confidence_rate":1},{"cnt":[[370,1495],[1880,1495],[1880,1540],[370,1540]],"region":{"top_left_x":369,"top_left_y":1495,"width":1511,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7a0e885bd9f471a91d4e2d9085bdc9e","type":"text","conversion_output":true,"text":"chance of avoiding invasive fungal infections during your treatment for AML, but we don't know","text_display":" chance of avoiding invasive fungal infections during your treatment for AML, but we don't know","confidence":0.9985356330871582,"confidence_rate":0.9999851976838389},{"cnt":[[370,1538],[1240,1538],[1240,1583],[370,1583]],"region":{"top_left_x":369,"top_left_y":1538,"width":871,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b26622c0b6fa436ea64c70d5ec107bb6","type":"text","conversion_output":true,"text":"for sure if there is any benefit of being part of this study.","text_display":" for sure if there is any benefit of being part of this study.","confidence":1,"confidence_rate":1},{"cnt":[[305,1624],[1878,1624],[1878,1674],[305,1674]],"region":{"top_left_x":305,"top_left_y":1624,"width":1573,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3695669418f48488e3e89ecc6b44c9d","type":"text","conversion_output":true,"text":"5. Sometimes bad things can happen to people when they are in a research study. These bad things","text_display":"\n5. Sometimes bad things can happen to people when they are in a research study. These bad things","confidence":1,"confidence_rate":1},{"cnt":[[370,1671],[1880,1671],[1880,1717],[370,1717]],"region":{"top_left_x":369,"top_left_y":1671,"width":1511,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"05f635bf270b450abac8a0b4ceaad16f","type":"text","conversion_output":true,"text":"are called \"risks.\" There is a risk that you will have bad effects from the newer antifungal agent","text_display":" are called \"risks.\" There is a risk that you will have bad effects from the newer antifungal agent","confidence":1,"confidence_rate":1},{"cnt":[[370,1714],[1880,1714],[1880,1760],[370,1760]],"region":{"top_left_x":369,"top_left_y":1714,"width":1511,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a332e4821924d92a060dbd385fb0e17","type":"text","conversion_output":true,"text":"or that it will not be better at preventing you from getting invasive fungal infections during your","text_display":" or that it will not be better at preventing you from getting invasive fungal infections during your","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[370,1757],[1646,1757],[1646,1803],[370,1803]],"region":{"top_left_x":369,"top_left_y":1757,"width":1277,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db78c7dcc0f14310b50e249499c42a5f","type":"text","conversion_output":true,"text":"treatment for AML. Other things may happen to you that we don't yet know about.","text_display":" treatment for AML. Other things may happen to you that we don't yet know about.","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[305,1843],[1880,1843],[1880,1893],[305,1893]],"region":{"top_left_x":305,"top_left_y":1843,"width":1575,"height":50},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2779f002087e43bb89d6ad088f8368c7","type":"text","conversion_output":true,"text":"6. Your family can choose to be part of this study or not. Your family can also decide to stop being","text_display":"\n6. Your family can choose to be part of this study or not. Your family can also decide to stop being","confidence":1,"confidence_rate":1},{"cnt":[[370,1891],[1880,1891],[1880,1936],[370,1936]],"region":{"top_left_x":369,"top_left_y":1890,"width":1511,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfe73217219f4ebfa221f5b793b6ac01","type":"text","conversion_output":true,"text":"in this study at any time once you start. There may be other treatments for your illness that your","text_display":" in this study at any time once you start. There may be other treatments for your illness that your","confidence":1,"confidence_rate":1},{"cnt":[[370,1934],[1680,1934],[1680,1979],[370,1979]],"region":{"top_left_x":369,"top_left_y":1933,"width":1312,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e812def623a4c33b2707332fb62e640","type":"text","conversion_output":true,"text":"doctor can tell you about. Make sure to ask your doctors any questions that you have.","text_display":" doctor can tell you about. Make sure to ask your doctors any questions that you have.","confidence":1,"confidence_rate":1},{"cnt":[[305,2020],[1878,2020],[1878,2069],[305,2069]],"region":{"top_left_x":305,"top_left_y":2019,"width":1573,"height":50},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57617a3a33f949a9a6ea1bd7fc56b983","type":"text","conversion_output":true,"text":"7. We are asking your permission to collect additional blood for some special tests. We want to see","text_display":"\n7. We are asking your permission to collect additional blood for some special tests. 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We also want extra blood samples for another special blood test that looks at","text_display":" the usual tests used. 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SHEET REGARDING RESEARCH STUDY ACCL0933","text_display":"\n\n\\title{\nINFORMATION SHEET REGARDING RESEARCH STUDY ACCL0933","confidence":1,"confidence_rate":1},{"cnt":[[709,339],[1412,339],[1412,385],[709,385]],"region":{"top_left_x":708,"top_left_y":339,"width":704,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45380a2a8bca49bdaef71f2ff8f180ea","type":"text","conversion_output":true,"parent_id":"6e6b2d321e184e6fa38e23cf1246d006","text":"(for teens from 13 through 17 years of age)","text_display":" (for teens from 13 through 17 years of age)\n}","confidence":1,"confidence_rate":1},{"cnt":[[305,434],[1820,434],[1820,479],[305,479]],"region":{"top_left_x":305,"top_left_y":433,"width":1515,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5276a8d2482c4714b49ac776a80cf621","type":"text","conversion_output":true,"text":"A Research Study Comparing 2 Drugs Used To Prevent Serious Fungal Infections In Children and","text_display":"\n\nA Research Study Comparing 2 Drugs Used To Prevent Serious Fungal Infections In Children and","confidence":0.9985356330871582,"confidence_rate":0.9999853457059158},{"cnt":[[713,477],[1407,477],[1407,526],[713,526]],"region":{"top_left_x":713,"top_left_y":476,"width":695,"height":51},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaf942425806476babfc5b9b60173e2c","type":"text","conversion_output":true,"text":"Adolescents With Acute Myeloid Leukemia.","text_display":" Adolescents With Acute Myeloid Leukemia.","confidence":0.99560546875,"confidence_rate":0.9999021333318117},{"cnt":[[309,567],[1876,567],[1876,612],[309,612]],"region":{"top_left_x":309,"top_left_y":567,"width":1567,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb49949e7e464d67a80809b204548c2e","type":"text","conversion_output":true,"text":"1. We have been talking with you about your likelihood of getting Invasive Fungal Infections.","text_display":"\n1. We have been talking with you about your likelihood of getting Invasive Fungal Infections.","confidence":1,"confidence_rate":1},{"cnt":[[370,610],[1880,610],[1880,657],[370,657]],"region":{"top_left_x":369,"top_left_y":610,"width":1511,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3bf3357492148438e909002c6d54bda","type":"text","conversion_output":true,"text":"Invasive Fungal Infections are infections which occur in people whose natural infection-fighting","text_display":" Invasive Fungal Infections are infections which occur in people whose natural infection-fighting","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[370,655],[1880,655],[1880,700],[370,700]],"region":{"top_left_x":369,"top_left_y":655,"width":1511,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e476188902594f2faffffa09f9f8e353","type":"text","conversion_output":true,"text":"ability (also called immunity) have been reduced. The strong cancer fighting drugs (called","text_display":" ability (also called immunity) have been reduced. The strong cancer fighting drugs (called","confidence":1,"confidence_rate":1},{"cnt":[[370,700],[1878,700],[1878,746],[370,746]],"region":{"top_left_x":369,"top_left_y":700,"width":1509,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e86419d8db0f4677bb4b072b0fd9a78c","type":"text","conversion_output":true,"text":"chemotherapy) used to treat your acute myeloid leukemia (AML) reduce your immunity and","text_display":" chemotherapy) used to treat your acute myeloid leukemia (AML) reduce your immunity and","confidence":1,"confidence_rate":1},{"cnt":[[370,743],[1132,743],[1132,788],[370,788]],"region":{"top_left_x":369,"top_left_y":743,"width":764,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b4e230210ce431892e177f7a56f46d2","type":"text","conversion_output":true,"text":"make you likely to get invasive fungal infections.","text_display":" make you likely to get invasive fungal infections.","confidence":0.9970703125,"confidence_rate":0.9999466561967442},{"cnt":[[305,829],[1876,829],[1876,879],[305,879]],"region":{"top_left_x":305,"top_left_y":829,"width":1571,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a250e4e128ad476591e3adbf68a08c52","type":"text","conversion_output":true,"text":"2. We are asking you to take part in a research study because you are at risk of invasive fungal","text_display":"\n2. We are asking you to take part in a research study because you are at risk of invasive fungal","confidence":1,"confidence_rate":1},{"cnt":[[370,877],[1878,877],[1878,922],[370,922]],"region":{"top_left_x":369,"top_left_y":876,"width":1509,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"229d86bc06cd44c788a1e2887d2d5c14","type":"text","conversion_output":true,"text":"infections. A research study is when doctors work together to try out new ways to help people","text_display":" infections. A research study is when doctors work together to try out new ways to help people","confidence":1,"confidence_rate":1},{"cnt":[[370,920],[1878,920],[1878,965],[370,965]],"region":{"top_left_x":369,"top_left_y":919,"width":1509,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e7f92dfad0a4878b1801d025d5dca57","type":"text","conversion_output":true,"text":"who are sick. In this study, we are trying to find better ways to prevent invasive fungal infections","text_display":" who are sick. In this study, we are trying to find better ways to prevent invasive fungal infections","confidence":0.9990234375,"confidence_rate":0.9999906949037896},{"cnt":[[370,962],[900,962],[900,1003],[370,1003]],"region":{"top_left_x":369,"top_left_y":962,"width":532,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcdef006fc4844bfa424322c2845ce0c","type":"text","conversion_output":true,"text":"in children on treatment for AML.","text_display":" in children on treatment for AML.","confidence":1,"confidence_rate":1},{"cnt":[[305,1098],[305,1048],[1878,1051],[1878,1100]],"region":{"top_left_x":305,"top_left_y":1048,"width":1573,"height":52},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fad173c63da4ca18258a5b6e1a9b5d2","type":"text","conversion_output":true,"text":"3. Children who are part of this study will be given medicines that help prevent invasive fungal","text_display":"\n3. Children who are part of this study will be given medicines that help prevent invasive fungal","confidence":1,"confidence_rate":1},{"cnt":[[370,1096],[1880,1096],[1880,1141],[370,1141]],"region":{"top_left_x":369,"top_left_y":1095,"width":1511,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d6c82a81209471599b90371951e49ba","type":"text","conversion_output":true,"text":"infections. These drugs are called antifungal agents. Children and adolescents that are part of this","text_display":" infections. These drugs are called antifungal agents. Children and adolescents that are part of this","confidence":1,"confidence_rate":1},{"cnt":[[370,1139],[1876,1139],[1876,1184],[370,1184]],"region":{"top_left_x":369,"top_left_y":1138,"width":1507,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24c853ed002b47939baff0322b6e6a04","type":"text","conversion_output":true,"text":"study will be placed into 1 of 2 treatment groups by a process called randomization.","text_display":" study will be placed into 1 of 2 treatment groups by a process called randomization.","confidence":1,"confidence_rate":1},{"cnt":[[370,1182],[1880,1182],[1880,1229],[370,1229]],"region":{"top_left_x":369,"top_left_y":1181,"width":1511,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46249296f0034414b72c70899f57e7e4","type":"text","conversion_output":true,"text":"Randomization means that the study treatment groups are assigned by chance, and is like flipping","text_display":" Randomization means that the study treatment groups are assigned by chance, and is like flipping","confidence":1,"confidence_rate":1},{"cnt":[[370,1227],[1878,1227],[1878,1274],[370,1274]],"region":{"top_left_x":369,"top_left_y":1226,"width":1509,"height":49},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"587147906e594e9fba71a47835f2d236","type":"text","conversion_output":true,"text":"a coin, only it is done by a computer. In this study, one group of children will get the usual","text_display":" a coin, only it is done by a computer. In this study, one group of children will get the usual","confidence":1,"confidence_rate":1},{"cnt":[[370,1272],[1880,1272],[1880,1317],[370,1317]],"region":{"top_left_x":369,"top_left_y":1271,"width":1511,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1211c8b78e0743eb9a24e58536be8374","type":"text","conversion_output":true,"text":"antifungal drug called fluconazole. The other group will get a newer antifungal agent called","text_display":" antifungal drug called fluconazole. The other group will get a newer antifungal agent called","confidence":1,"confidence_rate":1},{"cnt":[[370,1315],[1880,1315],[1880,1360],[370,1360]],"region":{"top_left_x":369,"top_left_y":1314,"width":1511,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca07a0666c124acd93ee0d8893d3a861","type":"text","conversion_output":true,"text":"caspofungin. Your doctor will tell you which group you are in. We do not know if the newer","text_display":" caspofungin. Your doctor will tell you which group you are in. We do not know if the newer","confidence":1,"confidence_rate":1},{"cnt":[[370,1358],[1876,1358],[1876,1403],[370,1403]],"region":{"top_left_x":369,"top_left_y":1357,"width":1507,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df22742fa660423bb38507a7a2568c5e","type":"text","conversion_output":true,"text":"antifungal agent will be better than the usual treatment at preventing invasive fungal infections.","text_display":" antifungal agent will be better than the usual treatment at preventing invasive fungal infections.","confidence":1,"confidence_rate":1},{"cnt":[[370,1401],[930,1401],[930,1448],[370,1448]],"region":{"top_left_x":369,"top_left_y":1400,"width":562,"height":49},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0b425dea6694abb9568244e9b9560ae","type":"text","conversion_output":true,"text":"That is why we are doing this study.","text_display":" That is why we are doing this study.","confidence":1,"confidence_rate":1},{"cnt":[[305,1491],[1878,1491],[1878,1536],[305,1536]],"region":{"top_left_x":305,"top_left_y":1491,"width":1573,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"959466467aa549e9aadd791778cd845d","type":"text","conversion_output":true,"text":"4. Sometimes good things can happen to people when they are in a research study. These good","text_display":"\n4. Sometimes good things can happen to people when they are in a research study. These good","confidence":1,"confidence_rate":1},{"cnt":[[370,1534],[1880,1534],[1880,1579],[370,1579]],"region":{"top_left_x":369,"top_left_y":1533,"width":1511,"height":47},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4da64dd57e14ec9a9c368c5134fa8a3","type":"text","conversion_output":true,"text":"things are called \"benefits.\" We hope that a benefit to you of being part of this study is a better","text_display":" things are called \"benefits.\" We hope that a benefit to you of being part of this study is a better","confidence":1,"confidence_rate":1},{"cnt":[[370,1577],[1880,1577],[1880,1622],[370,1622]],"region":{"top_left_x":369,"top_left_y":1576,"width":1511,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc9c3cddb35c4cdca1c1ae0777cf2e34","type":"text","conversion_output":true,"text":"chance of avoiding invasive fungal infections during your treatment for AML, but we don't know","text_display":" chance of avoiding invasive fungal infections during your treatment for AML, but we don't know","confidence":0.9990236759185791,"confidence_rate":0.999990133371946},{"cnt":[[370,1620],[1240,1620],[1240,1669],[370,1669]],"region":{"top_left_x":369,"top_left_y":1619,"width":871,"height":51},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06b4dca0b71344b98281dbc3e05c9867","type":"text","conversion_output":true,"text":"for sure if there is any benefit of being part of this study.","text_display":" for sure if there is any benefit of being part of this study.","confidence":1,"confidence_rate":1},{"cnt":[[305,1710],[1878,1710],[1878,1755],[305,1755]],"region":{"top_left_x":305,"top_left_y":1710,"width":1573,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13acd2962c6d443a8ea342cca3131679","type":"text","conversion_output":true,"text":"5. Sometimes bad things can happen to people when they are in a research study. These bad things","text_display":"\n5. Sometimes bad things can happen to people when they are in a research study. These bad things","confidence":1,"confidence_rate":1},{"cnt":[[370,1753],[1880,1753],[1880,1798],[370,1798]],"region":{"top_left_x":369,"top_left_y":1753,"width":1511,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33285d8c1c1b43e5972116b582b19201","type":"text","conversion_output":true,"text":"are called \"risks.\" There is a risk that you will have bad effects from the newer antifungal agent","text_display":" are called \"risks.\" There is a risk that you will have bad effects from the newer antifungal agent","confidence":1,"confidence_rate":1},{"cnt":[[370,1796],[1880,1796],[1880,1843],[370,1843]],"region":{"top_left_x":369,"top_left_y":1796,"width":1511,"height":48},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcf256c2d8744deeb2845b7fadba34b1","type":"text","conversion_output":true,"text":"or that it will not be better at preventing you from getting invasive fungal infections during your","text_display":" or that it will not be better at preventing you from getting invasive fungal infections during your","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[370,1841],[1646,1841],[1646,1888],[370,1888]],"region":{"top_left_x":369,"top_left_y":1841,"width":1277,"height":48},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b05afbc7b25440f84339d99444f0c12","type":"text","conversion_output":true,"text":"treatment for AML. Other things may happen to you that we don't yet know about.","text_display":" treatment for AML. Other things may happen to you that we don't yet know about.","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[305,1929],[1880,1929],[1880,1974],[305,1974]],"region":{"top_left_x":305,"top_left_y":1929,"width":1575,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed834c4d57174e0aaccb6bd1977372b6","type":"text","conversion_output":true,"text":"6. Your family can choose to be part of this study or not. Your family can also decide to stop being","text_display":"\n6. Your family can choose to be part of this study or not. Your family can also decide to stop being","confidence":1,"confidence_rate":1},{"cnt":[[370,1972],[1880,1972],[1880,2020],[370,2020]],"region":{"top_left_x":369,"top_left_y":1972,"width":1511,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6e7281a4e124bbd82a5a88dbc20dc78","type":"text","conversion_output":true,"text":"in this study at any time once you start. There may be other treatments for your illness that your","text_display":" in this study at any time once you start. There may be other treatments for your illness that your","confidence":1,"confidence_rate":1},{"cnt":[[370,2015],[1680,2015],[1680,2065],[370,2065]],"region":{"top_left_x":369,"top_left_y":2015,"width":1312,"height":50},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"501b6105f9f24640896d0b591d0b6781","type":"text","conversion_output":true,"text":"doctor can tell you about. Make sure to ask your doctors any questions that you have.","text_display":" doctor can tell you about. Make sure to ask your doctors any questions that you have.","confidence":1,"confidence_rate":1},{"cnt":[[305,2105],[1878,2105],[1878,2151],[305,2151]],"region":{"top_left_x":305,"top_left_y":2105,"width":1573,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0ed175cd26f4ab09c131712782e7f17","type":"text","conversion_output":true,"text":"7. We are asking your permission to collect additional blood for some special tests. We want to see","text_display":"\n7. We are asking your permission to collect additional blood for some special tests. 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1 of the following:","text_display":"\n        Mold in sputum, bronchoalveolar lavage fluid, bronchial brush, or sinus aspirate samples, indicated by 1 of the following:","confidence":1,"confidence_rate":1},{"cnt":[[339,1646],[926,1646],[926,1687],[339,1687]],"region":{"top_left_x":339,"top_left_y":1645,"width":587,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d57e42893b234d4ca6f084697ce517df","type":"pseudocode","conversion_output":true,"parent_id":"00eb2ce4f22b4d7e8d560deba60219fb","text":"Presence of fungal elements indicating a mold","text_display":"\n            Presence of fungal elements indicating a 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zygomycoses","confidence":0.9970703125,"confidence_rate":0.9999580867721726},{"cnt":[[339,1886],[720,1886],[720,1927],[339,1927]],"region":{"top_left_x":339,"top_left_y":1886,"width":381,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63ddbed6fe0f4dd4a958ccae00f94bb9","type":"pseudocode","conversion_output":true,"parent_id":"00eb2ce4f22b4d7e8d560deba60219fb","text":"\\(\\beta\\)-D-glucan detected in serum","text_display":"\n            \\(\\beta\\)-D-glucan detected in 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Probable IFD requires the presence of a host factor, a clinical criterion, and a mycological criterion. Cases that meet the criteria for a host","text_display":"\n\n\\footnotetext{\nNOTE. Probable IFD requires the presence of a host factor, a clinical criterion, and a mycological criterion. Cases that meet the criteria for a host","confidence":1,"confidence_rate":1},{"cnt":[[247,1977],[1403,1977],[1403,2009],[247,2009]],"region":{"top_left_x":247,"top_left_y":1976,"width":1156,"height":33},"line":51,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fd1abd693a0649588b5c59ed75393d77","type":"text","conversion_output":true,"parent_id":"db6de71fe28d47f8879e3089f2156824","text":"factor and a clinical criterion but for which mycological criteria are absent are considered possible IFD.","text_display":" factor and a clinical criterion but for which mycological criteria are absent are considered possible IFD.","confidence":1,"confidence_rate":1},{"cnt":[[292,2013],[1880,2013],[1880,2047],[292,2047]],"region":{"top_left_x":292,"top_left_y":2013,"width":1588,"height":35},"line":52,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4383caf9296247b59de8355e7e8b6e14","type":"text","conversion_output":true,"parent_id":"db6de71fe28d47f8879e3089f2156824","text":"\\({ }^{ a }\\) Host factors are not synonymous with risk factors and are characteristics by which individuals predisposed to invasive fungal diseases can","text_display":"\n\\({ }^{ a }\\) Host factors are not synonymous with risk factors and are characteristics by which individuals predisposed to invasive fungal diseases can","confidence":0.720703125,"confidence_rate":0.9978754549759733},{"cnt":[[245,2045],[1878,2045],[1878,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2045,"width":1634,"height":37},"line":53,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"579e3af1a2c345668fd6996f6ec417d2","type":"text","conversion_output":true,"parent_id":"db6de71fe28d47f8879e3089f2156824","text":"be recognized. They are intended primarily to apply to patients given treatment for malignant disease and to recipients of allogeneic","text_display":" be recognized. They are intended primarily to apply to patients given treatment for malignant disease and to recipients of allogeneic","confidence":1,"confidence_rate":1},{"cnt":[[245,2080],[1878,2080],[1878,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2079,"width":1634,"height":33},"line":54,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fc39646cf3c84ff0bd6699d645c8f87b","type":"text","conversion_output":true,"parent_id":"db6de71fe28d47f8879e3089f2156824","text":"hematopoietic stem cell and solid-organ transplants. These host factors are also applicable to patients who receive corticosteroids and other T cell","text_display":" hematopoietic stem cell and solid-organ transplants. 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Groll AH, Kurz M, Schneider W, et al: Five-year-survey of invasive aspergillosis in a paediatric","text_display":"\n1. Groll AH, Kurz M, Schneider W, et al: Five-year-survey of invasive aspergillosis in a paediatric","confidence":1,"confidence_rate":1},{"cnt":[[370,451],[1807,451],[1807,496],[370,496]],"region":{"top_left_x":369,"top_left_y":451,"width":1438,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4e6aea609de4946b0ca2ba3e88bb0b8","type":"text","conversion_output":true,"text":"cancer centre. Epidemiology, management and long-term survival. Mycoses 42:431-42, 1999","text_display":" cancer centre. Epidemiology, management and long-term survival. 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In patients who died from infections while","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1880,1543],[1880,1588],[245,1588]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcda463e70ef4055a2a253ece761e6c2","type":"text","conversion_output":true,"text":"receiving treatment for AML, an invasive fungal infection was the cause in more than half of the","text_display":" receiving treatment for AML, an invasive fungal infection was the cause in more than half of the","confidence":0.99560546875,"confidence_rate":0.9999563948558315},{"cnt":[[245,1586],[1880,1586],[1880,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1585,"width":1636,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5567859c2da34c8ab910e12c339b160e","type":"text","conversion_output":true,"text":"cases. Preventing invasive fungal infections due to chemotherapy is therefore very important for","text_display":" cases. Preventing invasive fungal infections due to chemotherapy is therefore very important for","confidence":1,"confidence_rate":1},{"cnt":[[245,1629],[973,1629],[973,1678],[245,1678]],"region":{"top_left_x":244,"top_left_y":1628,"width":730,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c767a1b81984bc2a72cc3064331610e","type":"text","conversion_output":true,"text":"the treatment success of people with AML.","text_display":" the treatment success of people with AML.","confidence":1,"confidence_rate":1},{"cnt":[[245,1710],[1880,1710],[1880,1760],[245,1760]],"region":{"top_left_x":244,"top_left_y":1710,"width":1636,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a5181ac3b5e4e06b403903b5d94c373","type":"text","conversion_output":true,"text":"This study is called a clinical trial. A clinical trial is a research study involving treatment of a","text_display":"\n\nThis study is called a clinical trial. A clinical trial is a research study involving treatment of a","confidence":1,"confidence_rate":1},{"cnt":[[245,1755],[1880,1755],[1880,1803],[245,1803]],"region":{"top_left_x":244,"top_left_y":1755,"width":1636,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"434aae9bab36463992a8e805e0b478f3","type":"text","conversion_output":true,"text":"disease in human patients. This study is organized by Children's Oncology Group (COG). COG","text_display":" disease in human patients. This study is organized by Children's Oncology Group (COG). COG","confidence":1,"confidence_rate":1},{"cnt":[[245,1796],[1880,1796],[1880,1843],[245,1843]],"region":{"top_left_x":244,"top_left_y":1796,"width":1636,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d5127b3752f43a2a4c214889e3c9481","type":"text","conversion_output":true,"text":"is an international research group that conducts clinical trials for children with cancer. More than","text_display":" is an international research group that conducts clinical trials for children with cancer. More than","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1794,1835],[1794,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1550,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"406da6da01f44a90a98176a685cd6330","type":"text","conversion_output":true,"text":"200 hospitals in North America, Australia, New Zealand, and Europe are members of COG.","text_display":" 200 hospitals in North America, Australia, New Zealand, and Europe are members of COG.","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[245,1921],[1880,1921],[1880,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1636,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27bc9b4cd40e421c944210a081ad28a7","type":"text","conversion_output":true,"text":"It is common to enroll children and adolescents with cancer in a clinical trial that seeks to","text_display":"\n\nIt is common to enroll children and adolescents with cancer in a clinical trial that seeks to","confidence":1,"confidence_rate":1},{"cnt":[[245,1962],[1878,1962],[1878,2009],[245,2009]],"region":{"top_left_x":244,"top_left_y":1961,"width":1634,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de71ebc9e522462a950f0e77beb89f55","type":"text","conversion_output":true,"text":"improve cancer treatment over time. Clinical trials include only people who choose to take part.","text_display":" improve cancer treatment over time. Clinical trials include only people who choose to take part.","confidence":1,"confidence_rate":1},{"cnt":[[245,2004],[1880,2004],[1880,2052],[245,2052]],"region":{"top_left_x":244,"top_left_y":2004,"width":1636,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"416614ebc74647feaccfa3c5e583a3f4","type":"text","conversion_output":true,"text":"You have a choice between a standard preventive treatment for invasive fungal infections and","text_display":" You have a choice between a standard preventive treatment for invasive fungal infections and","confidence":0.994631290435791,"confidence_rate":0.9999445049123337},{"cnt":[[245,2045],[522,2045],[522,2090],[245,2090]],"region":{"top_left_x":244,"top_left_y":2045,"width":279,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"735d2bb414c64baa9fb128794090fd2f","type":"text","conversion_output":true,"text":"this clinical trial.","text_display":" this clinical trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,2127],[1880,2127],[1880,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2126,"width":1636,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2d0b4927f25416a96a8863432a0a339","type":"text","conversion_output":true,"text":"Please take your time to make your decision. You may want to discuss it with your friends and","text_display":"\n\nPlease take your time to make your decision. You may want to discuss it with your friends and","confidence":1,"confidence_rate":1},{"cnt":[[245,2172],[1880,2172],[1880,2219],[245,2219]],"region":{"top_left_x":244,"top_left_y":2172,"width":1636,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e29d23093872488a8ff2df8127a63c88","type":"text","conversion_output":true,"text":"family. We encourage parents to include their child in the discussion and decision to the extent","text_display":" family. 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The current standard antifungal drug used is called fluconazole.","text_display":" (called antifungal therapy). 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The","confidence":0.99755859375,"confidence_rate":0.9999753094831817},{"cnt":[[245,627],[1880,627],[1880,675],[245,675]],"region":{"top_left_x":244,"top_left_y":627,"width":1636,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14bb0f0fcb7b49e5b27312baa552ef7b","type":"text","conversion_output":true,"text":"results of these tests will not be returned to you and no treatment decisions will be based on the","text_display":" results of these tests will not be returned to you and no treatment decisions will be based on the","confidence":1,"confidence_rate":1},{"cnt":[[245,670],[1880,670],[1880,718],[245,718]],"region":{"top_left_x":244,"top_left_y":670,"width":1636,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6bc2f61409914e5284f9f20a669c3113","type":"text","conversion_output":true,"text":"results. The results of these tests will not be a part of your medical record. 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All people taking part in this study will be","text_display":"\n\nYou may have side effects while on this study. All people taking part in this study will be","confidence":1,"confidence_rate":1},{"cnt":[[245,632],[1880,632],[1880,679],[245,679]],"region":{"top_left_x":244,"top_left_y":631,"width":1636,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8001a2d03b0643119376b4a46ac50ab8","type":"text","conversion_output":true,"text":"carefully monitored for side effects. Side effects may be mild or very serious; and you","text_display":" carefully monitored for side effects. 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If you or your partner can get pregnant, it is important for you to use birth control","text_display":" baby. If you or your partner can get pregnant, it is important for you to use birth control","confidence":1,"confidence_rate":1},{"cnt":[[245,1057],[1880,1057],[1880,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1057,"width":1636,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9617f3053f0d485fbb4dbe5ac076fac0","type":"text","conversion_output":true,"text":"or not have sex while on this study. Check with your study doctor about what kind of","text_display":" or not have sex while on this study. 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Infections with Aspergillus are","text_display":" infections caused by filamentous fungi like Aspergillus. 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Candida.","confidence":1,"confidence_rate":1},{"cnt":[[245,1624],[1775,1624],[1775,1676],[245,1676]],"region":{"top_left_x":244,"top_left_y":1624,"width":1531,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7f9259da49841aba99f1f6f41c8f697","type":"text","conversion_output":true,"text":"The use of caspofungin may cause more complications than the use of fluconazole.","text_display":"\n\nThe use of caspofungin may cause more complications than the use of fluconazole.","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[245,1712],[1880,1712],[1880,1762],[245,1762]],"region":{"top_left_x":244,"top_left_y":1712,"width":1636,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"043b30d7532240aa9aab1446a36175e4","type":"text","conversion_output":true,"text":"The caspofungin treatment that is being studied could be less effective than the current","text_display":"\nThe caspofungin treatment that is being studied could be less effective than the current","confidence":1,"confidence_rate":1},{"cnt":[[245,1757],[917,1757],[917,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1757,"width":674,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bfce6d186204386a3430cbe99db136c","type":"text","conversion_output":true,"text":"standard treatment with fluconazole.","text_display":" standard treatment with fluconazole.","confidence":1,"confidence_rate":1},{"cnt":[[245,1843],[1880,1843],[1880,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1843,"width":1636,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e838a163d57a412e93e51846a7a0bf7a","type":"text","conversion_output":true,"text":"In addition to the risks described above, there may be unknown risks, or risks that we did","text_display":"\n\nIn addition to the risks described above, there may be unknown risks, or risks that we did","confidence":1,"confidence_rate":1},{"cnt":[[245,1891],[1167,1891],[1167,1940],[245,1940]],"region":{"top_left_x":244,"top_left_y":1890,"width":923,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bafeafa343241f18a2f9864c3fddb94","type":"text","conversion_output":true,"text":"not anticipate, associated with being in this study.","text_display":" not anticipate, associated with being in this study.","confidence":1,"confidence_rate":1},{"cnt":[[245,1977],[1528,1977],[1528,2026],[245,2026]],"region":{"top_left_x":244,"top_left_y":1976,"width":1284,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9c7c73380d34538853c18b18e664b50","type":"text","conversion_output":true,"text":"Risks and side effects reported or expected with caspofungin include:","text_display":"\n\nRisks and side effects reported or expected with caspofungin 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This reaction requires immediate medical treatment. It may include fever, chills and skin rash. Less commonly wheezing, shortness of breath, swelling of the \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\begin{tabular}{l}\nLikely \\\\\nMay happen in 21 to 100 subjects out of every 100.\n\\end{tabular} & \\begin{tabular}{l}\nLess Likely \\\\\nMay happen in 20 or less than 20 subjects out of every 100.\n\\end{tabular} & Rare but serious \\\\\n\\hline \\begin{tabular}{l}\n- Fever (high temperature) \\\\\n- Chills \\\\\n- Rash \\\\\n- Diarrhea \\\\\n- Reaction that can occur during or following infusion of\n\\end{tabular} & \\begin{tabular}{l}\n- Fluid build-up in the tissues of the arms and legs \\\\\n- Pain and inflammation in the vein through which the drug was given \\\\\n- Nausea \\\\\n- Vomiting \\\\\n- Pain in the abdomen (belly)\n\\end{tabular} & - Allergic reaction which can be life-threatening and potentially fatal. 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