{"pages":[{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-001","page":1,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86f6a566f4224597874bb6ec956fde44","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f54b96673ac0448d84371ee1283ad8cc","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6efe849f76244d43965168d3a1953a30","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[750,279],[1377,279],[1377,354],[750,354]],"region":{"top_left_x":749,"top_left_y":279,"width":629,"height":76},"line":4,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"f55c01b5300543b5ae5b81c0d0fbeca8","type":"section_header","conversion_output":false,"children_ids":["faf421e375dd44ca9ada2582c0ea3e14"],"text":"","text_display":""},{"cnt":[[756,286],[1369,286],[1369,346],[756,346]],"region":{"top_left_x":756,"top_left_y":285,"width":613,"height":61},"line":5,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"faf421e375dd44ca9ada2582c0ea3e14","type":"text","conversion_output":true,"parent_id":"f55c01b5300543b5ae5b81c0d0fbeca8","text":"Clinical Trial Protocol","text_display":"\\section*{Clinical Trial Protocol}","confidence":1,"confidence_rate":1},{"cnt":[[251,387],[1865,387],[1865,2110],[251,2110]],"region":{"top_left_x":251,"top_left_y":386,"width":1614,"height":1724},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1a81e95fee8446984889871a51daade","type":"table","conversion_output":true,"children_ids":["5a93d9e343ce4029ba0c2bc63f3b6bf8","bcb05f54fb334e7097835b4676d80028","d8c2f88ee0cb4cc8b121068bba58bbc8","cbc4d9049f0d40ba87692706bc01a732","0a8263c3346642c086c53daad1de3625","8a55f30bd828408aac1de5b04b0177eb","3e8785a76d9440a48d3db47badebcea0","12d2b8abd0ce469db17a7a5db4c02ecc","5d86d5a3b65147758568908fecda88b1","6121e8a9a3e44ba191d388d375729d71","e5e05258df744d6bae94b5175e97f076","fd18219660024829aff2a5d5170fce83","10a4e8bed4e443e589ccbc42b4bf1421","fa42541e9d7d43a78822fe02547db8f9","bc82f938b1b743ab8d8e3616b57a3dc4","d2a7ae06ad33433eaaef908163491871","5fd3ce9725e44f34adf41c7e0de57e8f","5edd174114154db181c03abe2f8f6f8d","e4d53f9715c04306a682397596b0ce27","a1c8315661f540139e075d4db39674a1","833e0697a29b4d478c9741e110322505","08f6dc35be1c48e697d48b829209710c","e33c64b277fc44bebf90119653c29f1f","d15075c5d57c455a93856e70a6579cb1","580785c436224d55b5615ab64ebe2658","f924b765c78e41c2bfadeef8aa136eb6","e54dc7a769714513983b3362b4214026","52d5de834a534c6e97402e1a6282afef","161c591aa1bc4bd4ab1de76330263b64","25d44a37c4284ab8a227419862266647","6a77da98c7534e42992e5e9a6eb224eb","5bf408acf6cd49639b09f543119d533f"],"text":"\\begin{tabular}{|l|l|}\n\\hline Clinical Trial Protocol Number & EMR700692_006 \\\\\n\\hline Title & A multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD) \\\\\n\\hline Trial Phase & II \\\\\n\\hline IND Number & ![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-001.jpg?height=59\\&width=226\\&top_left_y=836\\&top_left_x=972) \\\\\n\\hline EudraCT Number & 2011-003059-20 \\\\\n\\hline Coordinating Investigator & PPD \\\\\n\\hline Sponsor & \\begin{tabular}{l}\nMerck KGaA \\\\\nFrankfurter Strasse 250, 64293 Darmstadt, Germany \\\\\n(for the USA) \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370 USA \\\\\nMedical Responsible: \\\\\nPPD \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370, USA\n\\end{tabular} \\\\\n\\hline Clinical Trial Protocol Version & 05 Mar 2013/Version 4.0 (including Amendments 1 and 2) \\\\\n\\hline Replaces Clinical Trial Protocol Version & 13 Oct 2011/Version 3.0 \\\\\n\\hline Current Clinical Trial Protocol Amendment & Amendment No. 2 (Global), 05 Mar 2013 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Clinical Trial Protocol Number & EMR700692_006 \\\\\n\\hline Title & A multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD) \\\\\n\\hline Trial Phase & II \\\\\n\\hline IND Number & ![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-001.jpg?height=59\\&width=226\\&top_left_y=836\\&top_left_x=972) \\\\\n\\hline EudraCT Number & 2011-003059-20 \\\\\n\\hline Coordinating Investigator & PPD \\\\\n\\hline Sponsor & \\begin{tabular}{l}\nMerck KGaA \\\\\nFrankfurter Strasse 250, 64293 Darmstadt, Germany \\\\\n(for the USA) \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370 USA \\\\\nMedical Responsible: \\\\\nPPD \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370, USA\n\\end{tabular} \\\\\n\\hline Clinical Trial Protocol Version & 05 Mar 2013/Version 4.0 (including Amendments 1 and 2) \\\\\n\\hline Replaces Clinical Trial Protocol Version & 13 Oct 2011/Version 3.0 \\\\\n\\hline Current Clinical Trial Protocol Amendment & Amendment No. 2 (Global), 05 Mar 2013 \\\\\n\\hline\n\\end{tabular}","confidence":0,"confidence_rate":0},{"cnt":[[253,386],[851,386],[851,2110],[253,2110]],"region":{"top_left_x":253,"top_left_y":386,"width":598,"height":1724},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a93d9e343ce4029ba0c2bc63f3b6bf8","type":"table_column","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[966,386],[1860,386],[1860,2110],[966,2110]],"region":{"top_left_x":965,"top_left_y":386,"width":895,"height":1724},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcb05f54fb334e7097835b4676d80028","type":"table_column","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,388],[1864,388],[1864,449],[251,449]],"region":{"top_left_x":251,"top_left_y":388,"width":1614,"height":61},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8c2f88ee0cb4cc8b121068bba58bbc8","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,460],[1864,460],[1864,758],[251,758]],"region":{"top_left_x":251,"top_left_y":459,"width":1614,"height":300},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbc4d9049f0d40ba87692706bc01a732","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,771],[1864,771],[1864,817],[251,817]],"region":{"top_left_x":251,"top_left_y":771,"width":1614,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a8263c3346642c086c53daad1de3625","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,836],[1864,836],[1864,897],[251,897]],"region":{"top_left_x":251,"top_left_y":836,"width":1614,"height":62},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a55f30bd828408aac1de5b04b0177eb","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,908],[1864,906],[1864,953],[251,956]],"region":{"top_left_x":250,"top_left_y":905,"width":1615,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e8785a76d9440a48d3db47badebcea0","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,971],[1864,971],[1864,1276],[251,1276]],"region":{"top_left_x":251,"top_left_y":970,"width":1614,"height":307},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12d2b8abd0ce469db17a7a5db4c02ecc","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,1280],[1864,1280],[1864,1765],[251,1765]],"region":{"top_left_x":251,"top_left_y":1280,"width":1614,"height":486},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d86d5a3b65147758568908fecda88b1","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,1776],[1864,1776],[1864,1880],[251,1880]],"region":{"top_left_x":251,"top_left_y":1776,"width":1614,"height":105},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6121e8a9a3e44ba191d388d375729d71","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,1893],[1864,1893],[1864,1993],[251,1993]],"region":{"top_left_x":251,"top_left_y":1893,"width":1614,"height":100},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5e05258df744d6bae94b5175e97f076","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[251,2010],[1864,2010],[1864,2108],[251,2108]],"region":{"top_left_x":251,"top_left_y":2010,"width":1614,"height":98},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd18219660024829aff2a5d5170fce83","type":"table_row","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"","text_display":""},{"cnt":[[264,397],[831,397],[831,436],[264,436]],"region":{"top_left_x":263,"top_left_y":396,"width":569,"height":40},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10a4e8bed4e443e589ccbc42b4bf1421","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"Clinical Trial Protocol Number","text_display":"Clinical Trial Protocol Number","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[974,397],[1277,397],[1277,442],[974,442]],"region":{"top_left_x":974,"top_left_y":396,"width":304,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa42541e9d7d43a78822fe02547db8f9","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"EMR700692_006","text_display":"EMR700692_006","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,468],[357,468],[357,505],[264,505]],"region":{"top_left_x":263,"top_left_y":468,"width":95,"height":38},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc82f938b1b743ab8d8e3616b57a3dc4","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"Title","text_display":"Title","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[970,464],[1858,464],[1858,754],[970,754]],"region":{"top_left_x":969,"top_left_y":463,"width":889,"height":292},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2a7ae06ad33433eaaef908163491871","type":"complex_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","children_ids":["ce798786fdc443d29844e8025a4277d4","c342426d9f974bbbbd834121328f1d5d","3b978ec669624095bb40018b27e9f7bd","509bd67683f448ac9971dd9ecd49cd1b","b3aef188f399412db7eaeba4a7a5d8de","b9a884a922924a2abe8b1447bf78d2fd"],"text":"A multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD)","text_display":"A multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD)","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9999959947684512},{"cnt":[[974,466],[1669,466],[1669,509],[974,509]],"region":{"top_left_x":974,"top_left_y":466,"width":696,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce798786fdc443d29844e8025a4277d4","type":"text","conversion_output":false,"parent_id":"d2a7ae06ad33433eaaef908163491871","text":"A multicenter, randomized, double-blind,","text_display":"A multicenter, randomized, double-blind,","confidence":1,"confidence_rate":1},{"cnt":[[974,514],[1667,514],[1667,561],[974,561]],"region":{"top_left_x":974,"top_left_y":513,"width":694,"height":49},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c342426d9f974bbbbd834121328f1d5d","type":"text","conversion_output":false,"parent_id":"d2a7ae06ad33433eaaef908163491871","text":"placebo-controlled, parallel-group trial to","text_display":" placebo-controlled, parallel-group trial to","confidence":1,"confidence_rate":1},{"cnt":[[974,561],[1747,561],[1747,607],[974,607]],"region":{"top_left_x":974,"top_left_y":561,"width":774,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b978ec669624095bb40018b27e9f7bd","type":"text","conversion_output":false,"parent_id":"d2a7ae06ad33433eaaef908163491871","text":"investigate the efficacy and safety of different","text_display":" investigate the efficacy and safety of different","confidence":1,"confidence_rate":1},{"cnt":[[974,607],[1856,607],[1856,655],[974,655]],"region":{"top_left_x":974,"top_left_y":606,"width":882,"height":49},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"509bd67683f448ac9971dd9ecd49cd1b","type":"text","conversion_output":false,"parent_id":"d2a7ae06ad33433eaaef908163491871","text":"intra-articular (i.a.) dosages of sprifermin in subjects","text_display":" intra-articular (i.a.) dosages of sprifermin in subjects","confidence":0.99853515625,"confidence_rate":0.9999759688513347},{"cnt":[[974,659],[1622,659],[1622,704],[974,704]],"region":{"top_left_x":974,"top_left_y":658,"width":648,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3aef188f399412db7eaeba4a7a5d8de","type":"text","conversion_output":false,"parent_id":"d2a7ae06ad33433eaaef908163491871","text":"with primary osteoarthritis of the knee","text_display":" with primary osteoarthritis of the knee","confidence":1,"confidence_rate":1},{"cnt":[[974,706],[1215,706],[1215,752],[974,752]],"region":{"top_left_x":974,"top_left_y":706,"width":241,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9a884a922924a2abe8b1447bf78d2fd","type":"text","conversion_output":false,"parent_id":"d2a7ae06ad33433eaaef908163491871","text":"(FORWARD)","text_display":" (FORWARD)","confidence":1,"confidence_rate":1},{"cnt":[[264,776],[478,776],[478,813],[264,813]],"region":{"top_left_x":263,"top_left_y":775,"width":216,"height":38},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fd3ce9725e44f34adf41c7e0de57e8f","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"Trial Phase","text_display":"Trial Phase","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[968,771],[1009,771],[1009,815],[968,815]],"region":{"top_left_x":967,"top_left_y":771,"width":42,"height":44},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5edd174114154db181c03abe2f8f6f8d","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"II","text_display":"II","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,845],[507,845],[507,882],[264,882]],"region":{"top_left_x":263,"top_left_y":845,"width":244,"height":37},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4d53f9715c04306a682397596b0ce27","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"IND Number","text_display":"IND Number","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[970,832],[1197,832],[1197,895],[970,895]],"region":{"top_left_x":969,"top_left_y":832,"width":229,"height":63},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1c8315661f540139e075d4db39674a1","type":"complex_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","children_ids":["a0880a4924f843e798ba088a81ef3fdb"],"text":"![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-001.jpg?height=59\\&width=226\\&top_left_y=836\\&top_left_x=972)","text_display":"![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-001.jpg?height=59\\&width=226\\&top_left_y=836\\&top_left_x=972)","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0,"confidence_rate":0},{"cnt":[[972,836],[1197,836],[1197,895],[972,895]],"region":{"top_left_x":972,"top_left_y":836,"width":226,"height":59},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0880a4924f843e798ba088a81ef3fdb","type":"diagram","conversion_output":false,"parent_id":"a1c8315661f540139e075d4db39674a1","text":"","text_display":"![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-001.jpg?height=59\\&width=226\\&top_left_y=836\\&top_left_x=972)"},{"cnt":[[264,910],[604,910],[604,951],[264,951]],"region":{"top_left_x":263,"top_left_y":910,"width":341,"height":42},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"833e0697a29b4d478c9741e110322505","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"EudraCT Number","text_display":"EudraCT Number","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[974,910],[1258,910],[1258,951],[974,951]],"region":{"top_left_x":974,"top_left_y":910,"width":284,"height":42},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08f6dc35be1c48e697d48b829209710c","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"2011-003059-20","text_display":"2011-003059-20","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,979],[738,979],[738,1029],[264,1029]],"region":{"top_left_x":263,"top_left_y":979,"width":476,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e33c64b277fc44bebf90119653c29f1f","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"Coordinating Investigator","text_display":"Coordinating Investigator","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[968,964],[1054,964],[1054,1007],[968,1007]],"region":{"top_left_x":967,"top_left_y":964,"width":88,"height":44},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d15075c5d57c455a93856e70a6579cb1","type":"complex_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","children_ids":["80c38c36572f49cb847c61d4060e5704"],"text":"PPD","text_display":"PPD","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[968,964],[1054,964],[1054,1007],[968,1007]],"region":{"top_left_x":967,"top_left_y":964,"width":88,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80c38c36572f49cb847c61d4060e5704","type":"text","conversion_output":false,"parent_id":"d15075c5d57c455a93856e70a6579cb1","text":"PPD","text_display":"PPD","confidence":1,"confidence_rate":1},{"cnt":[[264,1287],[418,1287],[418,1337],[264,1337]],"region":{"top_left_x":263,"top_left_y":1286,"width":155,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"580785c436224d55b5615ab64ebe2658","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"Sponsor","text_display":"Sponsor","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[968,1287],[1858,1287],[1858,1763],[968,1763]],"region":{"top_left_x":967,"top_left_y":1286,"width":891,"height":478},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f924b765c78e41c2bfadeef8aa136eb6","type":"complex_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","children_ids":["aadb899ff0e6452899c4e3b7c9874a15","d54d8cc8747940ebba98d8afe4014a88","1932fcecb6764bcb85c14b324fdf805d","3ce0ae8e37fb46f993c9cdb8534520e4","c73c99cd8e964c34a9a90e6d3d61dec1","e48be26511734a2d8a4797fc4390019d","6eda9c3623a64d98ac219508a7132423","a42d31952a63494eb7d8a26e78ac49ab","4180343b400f44fc83049f6949587481"],"text":"\\begin{tabular}{l}\nMerck KGaA \\\\\nFrankfurter Strasse 250, 64293 Darmstadt, Germany \\\\\n(for the USA) \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370 USA \\\\\nMedical Responsible: \\\\\nPPD \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370, USA\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nMerck KGaA \\\\\nFrankfurter Strasse 250, 64293 Darmstadt, Germany \\\\\n(for the USA) \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370 USA \\\\\nMedical Responsible: \\\\\nPPD \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370, USA\n\\end{tabular}","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99560546875,"confidence_rate":0.9999877871385848},{"cnt":[[974,1289],[1206,1289],[1206,1328],[974,1328]],"region":{"top_left_x":974,"top_left_y":1289,"width":232,"height":39},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aadb899ff0e6452899c4e3b7c9874a15","type":"text","conversion_output":false,"parent_id":"f924b765c78e41c2bfadeef8aa136eb6","text":"Merck KGaA","text_display":"Merck KGaA","confidence":1,"confidence_rate":1},{"cnt":[[974,1334],[1856,1334],[1856,1382],[974,1382]],"region":{"top_left_x":974,"top_left_y":1334,"width":882,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d54d8cc8747940ebba98d8afe4014a88","type":"text","conversion_output":false,"parent_id":"f924b765c78e41c2bfadeef8aa136eb6","text":"Frankfurter Strasse 250, 64293 Darmstadt, Germany","text_display":"\nFrankfurter Strasse 250, 64293 Darmstadt, Germany","confidence":0.99560546875,"confidence_rate":0.9999227360449264},{"cnt":[[974,1404],[1202,1404],[1202,1449],[974,1449]],"region":{"top_left_x":974,"top_left_y":1403,"width":228,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1932fcecb6764bcb85c14b324fdf805d","type":"text","conversion_output":false,"parent_id":"f924b765c78e41c2bfadeef8aa136eb6","text":"(for the USA)","text_display":"\n(for the USA)","confidence":1,"confidence_rate":1},{"cnt":[[974,1451],[1282,1451],[1282,1497],[974,1497]],"region":{"top_left_x":974,"top_left_y":1451,"width":308,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ce0ae8e37fb46f993c9cdb8534520e4","type":"text","conversion_output":false,"parent_id":"f924b765c78e41c2bfadeef8aa136eb6","text":"EMD Serono, Inc.","text_display":"\nEMD Serono, Inc.","confidence":0.99951171875,"confidence_rate":0.9999767431038692},{"cnt":[[974,1499],[1838,1499],[1838,1549],[974,1549]],"region":{"top_left_x":974,"top_left_y":1499,"width":865,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c73c99cd8e964c34a9a90e6d3d61dec1","type":"text","conversion_output":false,"parent_id":"f924b765c78e41c2bfadeef8aa136eb6","text":"One Technology Place, Rockland, MA 02370 USA","text_display":"\nOne Technology Place, Rockland, MA 02370 USA","confidence":0.99951171875,"confidence_rate":0.9999906077268363},{"cnt":[[972,1568],[1340,1568],[1340,1614],[972,1614]],"region":{"top_left_x":972,"top_left_y":1568,"width":369,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e48be26511734a2d8a4797fc4390019d","type":"text","conversion_output":false,"parent_id":"f924b765c78e41c2bfadeef8aa136eb6","text":"Medical Responsible:","text_display":"\nMedical Responsible:","confidence":1,"confidence_rate":1},{"cnt":[[968,1610],[1054,1610],[1054,1646],[968,1646]],"region":{"top_left_x":967,"top_left_y":1609,"width":88,"height":38},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6eda9c3623a64d98ac219508a7132423","type":"text","conversion_output":false,"parent_id":"f924b765c78e41c2bfadeef8aa136eb6","text":"PPD","text_display":"\nPPD","confidence":1,"confidence_rate":1},{"cnt":[[974,1664],[1284,1664],[1284,1709],[974,1709]],"region":{"top_left_x":974,"top_left_y":1663,"width":310,"height":47},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a42d31952a63494eb7d8a26e78ac49ab","type":"text","conversion_output":false,"parent_id":"f924b765c78e41c2bfadeef8aa136eb6","text":"EMD Serono, Inc.","text_display":"\nEMD Serono, Inc.","confidence":1,"confidence_rate":1},{"cnt":[[974,1711],[1847,1711],[1847,1761],[974,1761]],"region":{"top_left_x":974,"top_left_y":1711,"width":873,"height":51},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4180343b400f44fc83049f6949587481","type":"text","conversion_output":false,"parent_id":"f924b765c78e41c2bfadeef8aa136eb6","text":"One Technology Place, Rockland, MA 02370, USA","text_display":"\nOne Technology Place, Rockland, MA 02370, USA","confidence":1,"confidence_rate":1},{"cnt":[[264,1781],[825,1781],[825,1822],[264,1822]],"region":{"top_left_x":263,"top_left_y":1780,"width":562,"height":42},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e54dc7a769714513983b3362b4214026","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"Clinical Trial Protocol Version","text_display":"Clinical Trial Protocol Version","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[970,1776],[1851,1776],[1851,1878],[970,1878]],"region":{"top_left_x":969,"top_left_y":1776,"width":883,"height":103},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52d5de834a534c6e97402e1a6282afef","type":"complex_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","children_ids":["52d8baf2a7e64381969d402fa96db481","ed8386b9041b490185b5ac8a83d42a4e"],"text":"05 Mar 2013/Version 4.0 (including Amendments 1 and 2)","text_display":"05 Mar 2013/Version 4.0 (including Amendments 1 and 2)","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[974,1781],[1847,1781],[1847,1828],[974,1828]],"region":{"top_left_x":974,"top_left_y":1780,"width":873,"height":49},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52d8baf2a7e64381969d402fa96db481","type":"text","conversion_output":false,"parent_id":"52d5de834a534c6e97402e1a6282afef","text":"05 Mar 2013/Version 4.0 (including Amendments 1","text_display":"05 Mar 2013/Version 4.0 (including Amendments 1","confidence":1,"confidence_rate":1},{"cnt":[[974,1828],[1085,1828],[1085,1874],[974,1874]],"region":{"top_left_x":974,"top_left_y":1828,"width":111,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed8386b9041b490185b5ac8a83d42a4e","type":"text","conversion_output":false,"parent_id":"52d5de834a534c6e97402e1a6282afef","text":"and 2)","text_display":" and 2)","confidence":1,"confidence_rate":1},{"cnt":[[262,1895],[842,1895],[842,1991],[262,1991]],"region":{"top_left_x":261,"top_left_y":1895,"width":582,"height":96},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"161c591aa1bc4bd4ab1de76330263b64","type":"complex_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","children_ids":["4f079a6624784e2cb27d0895429b7df3","ce764034b54346a9af5fec255b00e6a9"],"text":"Replaces Clinical Trial Protocol Version","text_display":"Replaces Clinical Trial Protocol Version","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99755859375,"confidence_rate":0.9999669682301315},{"cnt":[[264,1898],[842,1898],[842,1947],[264,1947]],"region":{"top_left_x":263,"top_left_y":1897,"width":580,"height":51},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f079a6624784e2cb27d0895429b7df3","type":"text","conversion_output":false,"parent_id":"161c591aa1bc4bd4ab1de76330263b64","text":"Replaces Clinical Trial Protocol","text_display":"Replaces Clinical Trial Protocol","confidence":0.99755859375,"confidence_rate":0.9999339375513608},{"cnt":[[264,1947],[409,1947],[409,1986],[264,1986]],"region":{"top_left_x":263,"top_left_y":1947,"width":147,"height":40},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce764034b54346a9af5fec255b00e6a9","type":"text","conversion_output":false,"parent_id":"161c591aa1bc4bd4ab1de76330263b64","text":"Version","text_display":" Version","confidence":1,"confidence_rate":1},{"cnt":[[974,1898],[1392,1898],[1392,1939],[974,1939]],"region":{"top_left_x":974,"top_left_y":1897,"width":419,"height":42},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25d44a37c4284ab8a227419862266647","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"13 Oct 2011/Version 3.0","text_display":"13 Oct 2011/Version 3.0","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[262,2014],[834,2014],[834,2105],[262,2105]],"region":{"top_left_x":261,"top_left_y":2014,"width":573,"height":92},"line":58,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a77da98c7534e42992e5e9a6eb224eb","type":"complex_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","children_ids":["35dfabc3813247079705de37d385a547","b206d08c7b9c4f4ba5ec143e8565e724"],"text":"Current Clinical Trial Protocol Amendment","text_display":"Current Clinical Trial Protocol Amendment","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,2017],[829,2017],[829,2056],[264,2056]],"region":{"top_left_x":263,"top_left_y":2016,"width":567,"height":40},"line":59,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35dfabc3813247079705de37d385a547","type":"text","conversion_output":false,"parent_id":"6a77da98c7534e42992e5e9a6eb224eb","text":"Current Clinical Trial Protocol","text_display":"Current Clinical Trial Protocol","confidence":1,"confidence_rate":1},{"cnt":[[264,2062],[491,2062],[491,2103],[264,2103]],"region":{"top_left_x":263,"top_left_y":2062,"width":229,"height":42},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b206d08c7b9c4f4ba5ec143e8565e724","type":"text","conversion_output":false,"parent_id":"6a77da98c7534e42992e5e9a6eb224eb","text":"Amendment","text_display":" Amendment","confidence":1,"confidence_rate":1},{"cnt":[[972,2014],[1674,2014],[1674,2060],[972,2060]],"region":{"top_left_x":972,"top_left_y":2014,"width":702,"height":46},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bf408acf6cd49639b09f543119d533f","type":"simple_cell","conversion_output":false,"parent_id":"b1a81e95fee8446984889871a51daade","text":"Amendment No. 2 (Global), 05 Mar 2013","text_display":"Amendment No. 2 (Global), 05 Mar 2013","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.994140625,"confidence_rate":0.9998749735932828},{"cnt":[[243,2239],[1884,2239],[1884,2292],[243,2292]],"region":{"top_left_x":242,"top_left_y":2238,"width":1643,"height":55},"line":62,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8523f0206f64b2bb263438f9c1b0f12","type":"text","conversion_output":true,"text":"This document is the property of Merck KGaA, Darmstadt, Germany, or one of its affiliated","text_display":"\n\nThis document is the property of Merck KGaA, Darmstadt, Germany, or one of its affiliated","confidence":1,"confidence_rate":1},{"cnt":[[243,2288],[1884,2288],[1884,2340],[243,2340]],"region":{"top_left_x":242,"top_left_y":2288,"width":1643,"height":52},"line":63,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7e1caabb1e14aaeb13c9d4b10e0bb66","type":"text","conversion_output":true,"text":"companies. It is intended for restricted use only and may not - in full or part - be passed on,","text_display":" companies. It is intended for restricted use only and may not - in full or part - be passed on,","confidence":1,"confidence_rate":1},{"cnt":[[243,2338],[1884,2338],[1884,2387],[243,2387]],"region":{"top_left_x":242,"top_left_y":2337,"width":1643,"height":50},"line":64,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8b3104b1ede42239fc437377e83358a","type":"text","conversion_output":true,"text":"reproduced, published or used without express permission of Merck KGaA, Darmstadt,","text_display":" reproduced, published or used without express permission of Merck KGaA, Darmstadt,","confidence":1,"confidence_rate":1},{"cnt":[[243,2385],[1884,2385],[1884,2434],[243,2434]],"region":{"top_left_x":242,"top_left_y":2384,"width":1643,"height":51},"line":65,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1efe2d54c52844b1a6e8cae53114fe39","type":"text","conversion_output":true,"text":"Germany, or its affiliate. Copyright © 2013 by Merck KGaA, Darmstadt, Germany, or its","text_display":" Germany, or its affiliate. Copyright © 2013 by Merck KGaA, Darmstadt, Germany, or its","confidence":1,"confidence_rate":1},{"cnt":[[243,2432],[726,2432],[726,2481],[243,2481]],"region":{"top_left_x":242,"top_left_y":2432,"width":485,"height":50},"line":66,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afb2d412e06743f4bd854c56990dbcf4","type":"text","conversion_output":true,"text":"affiliate. All rights reserved.","text_display":" affiliate. All rights reserved.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":67,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fdc25817ac744aa281e72cf5eab44dba","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1525,2527],[1603,2527],[1603,2563],[1525,2563]],"region":{"top_left_x":1525,"top_left_y":2526,"width":78,"height":38},"line":68,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"85993d9c26874044afd0218ac8b062f6","type":"page_info","conversion_output":false,"text":"1/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":69,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b44b008810ac43a1b3f065ff7b14e5d6","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-002","page":2,"lines":[{"cnt":[[245,127],[436,127],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":126,"width":193,"height":49},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8eaa61797e9e4db5b57d92be4aaa3678","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1319,125],[1319,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":678,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"650fdf0527aa4605a5e4d08327d1a7f8","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2887fab950934e739e7300827d6e15c2","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[821,275],[821,331],[241,331]],"region":{"top_left_x":240,"top_left_y":275,"width":581,"height":56},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c3bfe28d2ce4909a62a245f629c094c","type":"section_header","conversion_output":false,"children_ids":["aaf950bd46d44c79acf17af6a89c8c9f"],"text":"","text_display":""},{"cnt":[[245,279],[814,279],[814,324],[245,324]],"region":{"top_left_x":244,"top_left_y":279,"width":571,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aaf950bd46d44c79acf17af6a89c8c9f","type":"text","conversion_output":true,"parent_id":"8c3bfe28d2ce4909a62a245f629c094c","text":"Previous Protocol Amendments","text_display":"\n\n\\section*{Previous Protocol Amendments}","confidence":1,"confidence_rate":1},{"cnt":[[245,350],[1293,350],[1293,402],[245,402]],"region":{"top_left_x":244,"top_left_y":350,"width":1050,"height":52},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5932a5aa5ecb470fbf5e4c4a3895514f","type":"text","conversion_output":true,"text":"- Amendment No. 1 (Non-substantial), 13 Oct 2011 (Global)","text_display":"\n- Amendment No. 1 (Non-substantial), 13 Oct 2011 (Global)","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d25c411063b941f0b761c357e83fa8dc","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[444,2543],[449,2545],[453,2550],[455,2558],[455,2567],[451,2573],[446,2575],[326,2584],[247,2584],[244,2582],[244,2548],[247,2545],[371,2543]],"region":{"top_left_x":244,"top_left_y":2543,"width":211,"height":41},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b8badd91b5b5429f9bee7c3c5da76a9f","type":"page_info","conversion_output":false,"text":"Object No.CCI","text_display":"","confidence":0.9960978019516915,"confidence_rate":0.999782810728577},{"cnt":[[1521,2527],[1601,2527],[1601,2563],[1521,2563]],"region":{"top_left_x":1521,"top_left_y":2526,"width":80,"height":38},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"34b555c3d0be467bbaa154055ba01a6d","type":"page_info","conversion_output":false,"text":"2/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-003","page":3,"lines":[{"cnt":[[284,172],[466,172],[466,215],[284,215]],"region":{"top_left_x":283,"top_left_y":171,"width":184,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3aed7e2c1e345b9b5088b0fbc1778af","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[666,172],[1313,172],[1313,213],[666,213]],"region":{"top_left_x":666,"top_left_y":171,"width":647,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8189799b8e5e4e5599a386989ba7e7fa","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[284,213],[563,213],[563,256],[284,256]],"region":{"top_left_x":283,"top_left_y":212,"width":280,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6cb16b3240d438ab5ee889658f9ca2b","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[279,357],[599,357],[599,419],[279,419]],"region":{"top_left_x":279,"top_left_y":356,"width":321,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2265c24b2a44c4aa4dded5a5c0e8f31","type":"section_header","conversion_output":false,"children_ids":["029c29e10fc142eca0004dc0d3ed9f8b"],"text":"","text_display":""},{"cnt":[[284,361],[595,361],[595,415],[284,415]],"region":{"top_left_x":283,"top_left_y":360,"width":313,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"029c29e10fc142eca0004dc0d3ed9f8b","type":"text","conversion_output":true,"parent_id":"b2265c24b2a44c4aa4dded5a5c0e8f31","text":"Signature Page","text_display":"\n\n\\section*{Signature Page}","confidence":1,"confidence_rate":1},{"cnt":[[279,449],[1261,449],[1261,505],[279,505]],"region":{"top_left_x":279,"top_left_y":449,"width":983,"height":56},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f25813c9f9342eb9fb92c007e25cbfa","type":"section_header","conversion_output":false,"children_ids":["0b24623f94524e519c958139bd9805fd"],"text":"","text_display":""},{"cnt":[[284,455],[1257,455],[1257,501],[284,501]],"region":{"top_left_x":283,"top_left_y":455,"width":974,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b24623f94524e519c958139bd9805fd","type":"text","conversion_output":true,"parent_id":"7f25813c9f9342eb9fb92c007e25cbfa","text":"Protocol Lead responsible for designing the clinical trial:","text_display":"\n\n\\section*{Protocol Lead responsible for designing the clinical trial:}","confidence":1,"confidence_rate":1},{"cnt":[[284,537],[930,537],[930,587],[284,587]],"region":{"top_left_x":283,"top_left_y":537,"width":648,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05405b72d53e4c339c848c4435e67743","type":"text","conversion_output":true,"text":"I approve the design of the clinical trial.","text_display":"\n\nI approve the design of the clinical trial.","confidence":1,"confidence_rate":1},{"cnt":[[266,612],[1852,612],[1852,1362],[266,1362]],"region":{"top_left_x":266,"top_left_y":612,"width":1586,"height":751},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c1d7fb059104c6ba7d17692bc6be854","type":"table","conversion_output":true,"children_ids":["e57ba5cd34a949de96df84422eb064d7","db94307a7ebc400ab20e0a8989bc5e99","2087e3a0b7004f17a1b17bdc92982a23","9dca9c44899845c89edc90b1f17bc379","1eea623c34434d26b63fc42d399273a1","77d44710851d4a9b9d65eb00f41ddb59","050da1ce3d6f4ee682d0bc72ab663a8d","3718dbdbd5254091aeb0d75d3db756f1","e92cb9204e5f4566870eec83c0b60e40","73815558dc5d451882ddcf19ee95db45","6a9ef89543074e11aa7db03f9022c646","b4ce3914cb6d4353be60c8ef29fd0243","cadbaa3caaf64e61a05c29be244b3d3b","1bb6f318f7874e269f29a582ac47addb","a561884a565847948e32f62daa224536","ee50a1221dad4b5e8cebe6dfb10f3bf5","3db8e5bdbd544d92b38931481c8d7b49","9e90824e5d7c4a4ab9d28bef252b4da9","43fc8bf084d3422a94948616a190ba0b","d48fab1e6246456bbbaf7e58133d8839","2838ec4808974439b9329b235e0ae68a","3130edfaf62d4db2af41493687456094","452415c345e84508b1401cbdf8dfee4e","727a468917ec40e1ad47c50a37279547","c40c02e15fe14084878b6dc290823415","eb41918e477c413caeebf8f77db9fb36","53412a0d9fa743ebb3eb8283cc2419da","4a9460e7c75e4b559596177f3752e5d7","1f522622681c47adb339ade7a759fe2f"],"text":"\\begin{tabular}{|l|l|}\n\\hline PPD & \\begin{tabular}{l}\n\\(\\_\\_\\_\\_\\) \\\\\nPPD\n\\end{tabular} \\\\\n\\hline Signature & Date of Signature \\\\\n\\hline Name, academic degree & PPD \\\\\n\\hline Function & PPD\n□ \\\\\n\\hline Institution & EMD Serono, Inc. \\\\\n\\hline Address & One Technology Place, Rockland, MA 02370 \\\\\n\\hline Telephone number & PPD \\\\\n\\hline Fax number & PPD \\\\\n\\hline E-mail address & PPD \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline PPD & \\begin{tabular}{l}\n\\(\\_\\_\\_\\_\\) \\\\\nPPD\n\\end{tabular} \\\\\n\\hline Signature & Date of Signature \\\\\n\\hline Name, academic degree & PPD \\\\\n\\hline Function & PPD\n□ \\\\\n\\hline Institution & EMD Serono, Inc. \\\\\n\\hline Address & One Technology Place, Rockland, MA 02370 \\\\\n\\hline Telephone number & PPD \\\\\n\\hline Fax number & PPD \\\\\n\\hline E-mail address & PPD \\\\\n\\hline\n\\end{tabular}","confidence":1,"confidence_rate":1},{"cnt":[[269,612],[678,612],[678,1362],[269,1362]],"region":{"top_left_x":268,"top_left_y":612,"width":410,"height":751},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e57ba5cd34a949de96df84422eb064d7","type":"table_column","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[716,612],[1461,612],[1461,1362],[716,1362]],"region":{"top_left_x":716,"top_left_y":612,"width":746,"height":751},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db94307a7ebc400ab20e0a8989bc5e99","type":"table_column","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[266,612],[1851,612],[1851,759],[266,759]],"region":{"top_left_x":266,"top_left_y":612,"width":1586,"height":148},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2087e3a0b7004f17a1b17bdc92982a23","type":"table_row","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[266,792],[1851,792],[1851,847],[266,847]],"region":{"top_left_x":266,"top_left_y":792,"width":1586,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dca9c44899845c89edc90b1f17bc379","type":"table_row","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[266,858],[1851,858],[1851,909],[266,909]],"region":{"top_left_x":266,"top_left_y":857,"width":1586,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1eea623c34434d26b63fc42d399273a1","type":"table_row","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[266,923],[1851,923],[1851,975],[266,975]],"region":{"top_left_x":266,"top_left_y":923,"width":1586,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77d44710851d4a9b9d65eb00f41ddb59","type":"table_row","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[266,1038],[1851,1038],[1851,1087],[266,1087]],"region":{"top_left_x":266,"top_left_y":1037,"width":1586,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"050da1ce3d6f4ee682d0bc72ab663a8d","type":"table_row","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[266,1103],[1851,1103],[1851,1155],[266,1155]],"region":{"top_left_x":266,"top_left_y":1103,"width":1586,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3718dbdbd5254091aeb0d75d3db756f1","type":"table_row","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[266,1166],[1851,1166],[1851,1220],[266,1220]],"region":{"top_left_x":266,"top_left_y":1165,"width":1586,"height":56},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e92cb9204e5f4566870eec83c0b60e40","type":"table_row","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[266,1231],[1851,1231],[1851,1286],[266,1286]],"region":{"top_left_x":266,"top_left_y":1231,"width":1586,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73815558dc5d451882ddcf19ee95db45","type":"table_row","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[266,1300],[1851,1300],[1851,1349],[266,1349]],"region":{"top_left_x":266,"top_left_y":1299,"width":1586,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a9ef89543074e11aa7db03f9022c646","type":"table_row","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"","text_display":""},{"cnt":[[271,617],[351,617],[351,661],[271,661]],"region":{"top_left_x":271,"top_left_y":617,"width":80,"height":45},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4ce3914cb6d4353be60c8ef29fd0243","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"PPD","text_display":"PPD","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1106,656],[1677,656],[1677,765],[1106,765]],"region":{"top_left_x":1106,"top_left_y":655,"width":571,"height":110},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cadbaa3caaf64e61a05c29be244b3d3b","type":"complex_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","children_ids":["8921a350915144bcb6f02fec3cb117ac","4ca351e1b4e84576b22f4a077152ad54"],"text":"\\begin{tabular}{l}\n\\(\\_\\_\\_\\_\\) \\\\\nPPD\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n\\(\\_\\_\\_\\_\\) \\\\\nPPD\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1106,656],[1677,656],[1677,759],[1106,759]],"region":{"top_left_x":1106,"top_left_y":655,"width":571,"height":105},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8921a350915144bcb6f02fec3cb117ac","type":"form_field","conversion_output":false,"parent_id":"cadbaa3caaf64e61a05c29be244b3d3b","text":"","text_display":"\\(\\_\\_\\_\\_\\)"},{"cnt":[[1166,661],[1248,661],[1248,699],[1166,699]],"region":{"top_left_x":1166,"top_left_y":661,"width":83,"height":39},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ca351e1b4e84576b22f4a077152ad54","type":"text","conversion_output":false,"parent_id":"cadbaa3caaf64e61a05c29be244b3d3b","text":"PPD","text_display":"\nPPD","confidence":1,"confidence_rate":1},{"cnt":[[282,798],[446,798],[446,844],[282,844]],"region":{"top_left_x":282,"top_left_y":797,"width":165,"height":47},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1bb6f318f7874e269f29a582ac47addb","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"Signature","text_display":"Signature","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1109,798],[1396,798],[1396,844],[1109,844]],"region":{"top_left_x":1109,"top_left_y":797,"width":287,"height":47},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a561884a565847948e32f62daa224536","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"Date of Signature","text_display":"Date of Signature","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[282,863],[673,863],[673,909],[282,909]],"region":{"top_left_x":282,"top_left_y":863,"width":391,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee50a1221dad4b5e8cebe6dfb10f3bf5","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"Name, academic degree","text_display":"Name, academic degree","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[719,863],[801,863],[801,901],[719,901]],"region":{"top_left_x":718,"top_left_y":863,"width":83,"height":39},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3db8e5bdbd544d92b38931481c8d7b49","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"PPD","text_display":"PPD","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[282,931],[432,931],[432,969],[282,969]],"region":{"top_left_x":282,"top_left_y":931,"width":151,"height":39},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e90824e5d7c4a4ab9d28bef252b4da9","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"Function","text_display":"Function","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[719,928],[934,928],[934,1021],[719,1021]],"region":{"top_left_x":718,"top_left_y":928,"width":217,"height":94},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43fc8bf084d3422a94948616a190ba0b","type":"complex_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","children_ids":["e759dbf63c394e319ebd7d6db322c34f","99a51907802e44569ec10ef7cbb4f70c"],"text":"PPD\n□","text_display":"PPD\n□","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[719,928],[801,928],[801,967],[719,967]],"region":{"top_left_x":718,"top_left_y":928,"width":83,"height":39},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e759dbf63c394e319ebd7d6db322c34f","type":"text","conversion_output":false,"parent_id":"43fc8bf084d3422a94948616a190ba0b","text":"PPD","text_display":"PPD","confidence":1,"confidence_rate":1},{"cnt":[[719,972],[934,972],[934,1021],[719,1021]],"region":{"top_left_x":718,"top_left_y":972,"width":217,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99a51907802e44569ec10ef7cbb4f70c","type":"form_field","conversion_output":false,"parent_id":"43fc8bf084d3422a94948616a190ba0b","text":"","text_display":"\n□","subtype":"box"},{"cnt":[[282,1043],[457,1043],[457,1081],[282,1081]],"region":{"top_left_x":282,"top_left_y":1043,"width":175,"height":39},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d48fab1e6246456bbbaf7e58133d8839","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"Institution","text_display":"Institution","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[719,1043],[1022,1043],[1022,1084],[719,1084]],"region":{"top_left_x":718,"top_left_y":1043,"width":304,"height":42},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2838ec4808974439b9329b235e0ae68a","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"EMD Serono, Inc.","text_display":"EMD Serono, Inc.","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[282,1109],[422,1109],[422,1144],[282,1144]],"region":{"top_left_x":282,"top_left_y":1108,"width":140,"height":37},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3130edfaf62d4db2af41493687456094","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"Address","text_display":"Address","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[719,1109],[1458,1109],[1458,1152],[719,1152]],"region":{"top_left_x":718,"top_left_y":1108,"width":741,"height":45},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"452415c345e84508b1401cbdf8dfee4e","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"One Technology Place, Rockland, MA 02370","text_display":"One Technology Place, Rockland, MA 02370","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[282,1174],[596,1174],[596,1220],[282,1220]],"region":{"top_left_x":282,"top_left_y":1174,"width":315,"height":47},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"727a468917ec40e1ad47c50a37279547","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"Telephone number","text_display":"Telephone number","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[719,1174],[801,1174],[801,1212],[719,1212]],"region":{"top_left_x":718,"top_left_y":1174,"width":83,"height":39},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c40c02e15fe14084878b6dc290823415","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"PPD","text_display":"PPD","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[282,1240],[487,1240],[487,1280],[282,1280]],"region":{"top_left_x":282,"top_left_y":1239,"width":205,"height":42},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb41918e477c413caeebf8f77db9fb36","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"Fax number","text_display":"Fax number","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[719,1240],[801,1240],[801,1278],[719,1278]],"region":{"top_left_x":718,"top_left_y":1239,"width":83,"height":39},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53412a0d9fa743ebb3eb8283cc2419da","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"PPD","text_display":"PPD","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[282,1305],[531,1305],[531,1346],[282,1346]],"region":{"top_left_x":282,"top_left_y":1304,"width":249,"height":42},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a9460e7c75e4b559596177f3752e5d7","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"E-mail address","text_display":"E-mail address","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[719,1305],[801,1305],[801,1343],[719,1343]],"region":{"top_left_x":718,"top_left_y":1304,"width":83,"height":40},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f522622681c47adb339ade7a759fe2f","type":"simple_cell","conversion_output":false,"parent_id":"9c1d7fb059104c6ba7d17692bc6be854","text":"PPD","text_display":"PPD","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[288,2466],[471,2466],[471,2499],[288,2499]],"region":{"top_left_x":287,"top_left_y":2466,"width":184,"height":33},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"20db2d8d199f4884a97ba646015589d7","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[288,2501],[428,2501],[428,2537],[288,2537]],"region":{"top_left_x":287,"top_left_y":2500,"width":141,"height":38},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5f63b86a785649409cfd27f2eae822ca","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2484],[1586,2484],[1586,2518],[1508,2518]],"region":{"top_left_x":1508,"top_left_y":2483,"width":78,"height":35},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d46ecb4899514f51b7c3a532e1c21a1a","type":"page_info","conversion_output":false,"text":"3/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1775,2458],[1869,2458],[1869,2557],[1775,2557]],"region":{"top_left_x":1774,"top_left_y":2457,"width":96,"height":100},"line":46,"column":0,"font_size":88,"is_printed":true,"is_handwritten":false,"id":"af163bb8cf99499da0ddb013413814ed","type":"page_info","conversion_output":false,"text":"80","text_display":"","confidence":0.7219183444976807,"confidence_rate":0.8496577808139467}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-004","page":4,"lines":[{"cnt":[[1126,47],[1190,47],[1190,90],[1126,90]],"region":{"top_left_x":1125,"top_left_y":47,"width":66,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f3a8daa83d54dc2a1ac0d248d63c44f","type":"page_info","conversion_output":false,"text":"Fax:","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1487,39],[1927,39],[1927,82],[1487,82]],"region":{"top_left_x":1486,"top_left_y":38,"width":442,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02ccb68887434aed9cef9a58445e6260","type":"page_info","conversion_output":false,"text":"Mar 72013 01:08pm P003/004","text_display":"","confidence":0.9990236759185791,"confidence_rate":0.9999712709716212},{"cnt":[[262,172],[449,172],[449,219],[262,219]],"region":{"top_left_x":262,"top_left_y":171,"width":188,"height":49},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecc9ca14fff141dd88445917bcc4f7fb","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":0.9771778956055641,"confidence_rate":0.9984620798139537},{"cnt":[[642,172],[1285,172],[1285,221],[642,221]],"region":{"top_left_x":642,"top_left_y":171,"width":643,"height":51},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf3645e753e8462c92f617e7dd879d08","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":0.5302433967590332,"confidence_rate":0.9856848336657331},{"cnt":[[260,215],[544,215],[544,260],[260,260]],"region":{"top_left_x":259,"top_left_y":214,"width":285,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"435ae3715df541eea14c166523dd6bad","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[260,357],[733,357],[733,415],[260,415]],"region":{"top_left_x":259,"top_left_y":356,"width":474,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba4e2ed5aba84bb99a28a8ef26654d87","type":"section_header","conversion_output":false,"children_ids":["890c213dacdc4062a86a0d4cdf96b2bd"],"text":"","text_display":""},{"cnt":[[262,357],[728,357],[728,410],[262,410]],"region":{"top_left_x":262,"top_left_y":356,"width":467,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"890c213dacdc4062a86a0d4cdf96b2bd","type":"text","conversion_output":true,"parent_id":"ba4e2ed5aba84bb99a28a8ef26654d87","text":"Coordinating Investigator:","text_display":"\n\n\\section*{Coordinating Investigator:}","confidence":1,"confidence_rate":1},{"cnt":[[262,440],[1824,440],[1824,494],[262,494]],"region":{"top_left_x":262,"top_left_y":440,"width":1563,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c2eff8bf6964a13af144774dedda53f","type":"text","conversion_output":true,"text":"I agree to conduct the clinical trial in accordance with this clinical trial protocol and in","text_display":"\n\nI agree to conduct the clinical trial in accordance with this clinical trial protocol and in","confidence":0.89599609375,"confidence_rate":0.9988684836822257},{"cnt":[[262,490],[1594,490],[1594,539],[262,539]],"region":{"top_left_x":262,"top_left_y":489,"width":1333,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48fad003dfd84045b70bcb189c0372cd","type":"text","conversion_output":true,"text":"compliance with Good Clinical Practice and all applicable regulatory requirements.","text_display":" compliance with Good Clinical Practice and all applicable regulatory requirements.","confidence":1,"confidence_rate":1},{"cnt":[[253,1353],[254,573],[1835,576],[1834,1355]],"region":{"top_left_x":252,"top_left_y":573,"width":1584,"height":783},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","type":"table","conversion_output":true,"children_ids":["f4df3095a2224969869f3918f25e10d4","27d9e9413e784b21ae8e48d8cabd09a0","31dc88733bc047f49e4220814fddb48e","83114a37d1ff40ab8602b5023e4c8e8c","600a4138c58a404398a8bba26ca05395","a5239c26dfd240b9878c4fe1ce8269ab","592315102e1844f49ba313747f053c95","998500cbcfc346ffa8853688a75f23eb","9955dfc0ac93473d981d079e74481088","63d07b2848d44261ab5b30aa7ae4fa95","a5d4175dc15f4bf28457146b3c0301f7","38c10bc4f37143749e169527e39d9502","64547ac5ac0b435588cbacceb0c1ad0a","961bd0f5f2b34a9b86f9404f5a7e3858","31d425ca6ba747ba8278bbec79e212ce","c3120fd19995409cbc9867674a7c6498","b713d5ba5c6647b68d44e82119b7277a","766a1ca01fa845e0b017b09b200c59d1","1501708df0ed45e985e34b2b7e55e577","e637f0d8d94d467db3559a2d96be3de1","34224c4c8c6145e1854d7162423564cf","a08ac84373df484f9b3a379372c8709a","e94314e4384b4a75abca0ee357928afe","4193d2f259bb4c81a1f404784acd0884","2a3ab5564acb40efa1e2ba70bf2fd553","3604e21b94d347f9bf946b0d2158faba"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{2}{|l|}{PPD} & PPD \\\\\n\\hline \\multicolumn{2}{|c|}{} & \\\\\n\\hline Signature & & Date of Signature \\\\\n\\hline Name, academic degree & PPD & \\\\\n\\hline Function & & \\\\\n\\hline Institution & & \\\\\n\\hline Address & & \\\\\n\\hline Telephone number & & \\\\\n\\hline Fax number & & \\\\\n\\hline E-mail address & & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{2}{|l|}{PPD} & PPD \\\\\n\\hline \\multicolumn{2}{|c|}{} & \\\\\n\\hline Signature & & Date of Signature \\\\\n\\hline Name, academic degree & PPD & \\\\\n\\hline Function & & \\\\\n\\hline Institution & & \\\\\n\\hline Address & & \\\\\n\\hline Telephone number & & \\\\\n\\hline Fax number & & \\\\\n\\hline E-mail address & & \\\\\n\\hline\n\\end{tabular}","confidence":0.98291015625,"confidence_rate":0.9998648419863484},{"cnt":[[260,573],[661,573],[661,1359],[260,1359]],"region":{"top_left_x":260,"top_left_y":573,"width":402,"height":786},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4df3095a2224969869f3918f25e10d4","type":"table_column","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[689,573],[768,573],[768,1356],[689,1356]],"region":{"top_left_x":688,"top_left_y":573,"width":80,"height":784},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27d9e9413e784b21ae8e48d8cabd09a0","type":"table_column","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[1076,573],[1379,573],[1379,1356],[1076,1356]],"region":{"top_left_x":1075,"top_left_y":573,"width":304,"height":784},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31dc88733bc047f49e4220814fddb48e","type":"table_column","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,573],[1837,573],[1837,641],[252,641]],"region":{"top_left_x":252,"top_left_y":573,"width":1586,"height":69},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83114a37d1ff40ab8602b5023e4c8e8c","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,660],[1837,656],[1837,718],[252,721]],"region":{"top_left_x":251,"top_left_y":656,"width":1587,"height":66},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"600a4138c58a404398a8bba26ca05395","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,741],[1837,737],[1837,794],[252,798]],"region":{"top_left_x":251,"top_left_y":737,"width":1587,"height":61},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5239c26dfd240b9878c4fe1ce8269ab","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,786],[1837,786],[1837,865],[252,865]],"region":{"top_left_x":252,"top_left_y":785,"width":1586,"height":80},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"592315102e1844f49ba313747f053c95","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,873],[1834,873],[1834,925],[252,925]],"region":{"top_left_x":252,"top_left_y":873,"width":1583,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"998500cbcfc346ffa8853688a75f23eb","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,982],[1837,982],[1837,1037],[252,1037]],"region":{"top_left_x":252,"top_left_y":982,"width":1586,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9955dfc0ac93473d981d079e74481088","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,1053],[1834,1053],[1834,1100],[252,1100]],"region":{"top_left_x":252,"top_left_y":1053,"width":1583,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63d07b2848d44261ab5b30aa7ae4fa95","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,1162],[1834,1162],[1834,1217],[252,1217]],"region":{"top_left_x":252,"top_left_y":1162,"width":1583,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5d4175dc15f4bf28457146b3c0301f7","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,1228],[1834,1228],[1834,1274],[252,1274]],"region":{"top_left_x":252,"top_left_y":1227,"width":1583,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38c10bc4f37143749e169527e39d9502","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[252,1293],[1837,1293],[1837,1345],[252,1345]],"region":{"top_left_x":252,"top_left_y":1293,"width":1586,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64547ac5ac0b435588cbacceb0c1ad0a","type":"table_row","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":""},{"cnt":[[263,578],[768,578],[768,630],[263,630]],"region":{"top_left_x":262,"top_left_y":578,"width":506,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"961bd0f5f2b34a9b86f9404f5a7e3858","type":"table_spanning_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","children_ids":["7a3a194272df42c5937fb43bcb24db51"],"text":"","text_display":"PPD","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":2},{"cnt":[[274,581],[350,581],[350,622],[274,622]],"region":{"top_left_x":273,"top_left_y":581,"width":78,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a3a194272df42c5937fb43bcb24db51","type":"simple_cell","conversion_output":false,"parent_id":"961bd0f5f2b34a9b86f9404f5a7e3858","text":"PPD","text_display":"PPD","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":2,"confidence":1,"confidence_rate":1},{"cnt":[[1084,578],[1660,578],[1660,641],[1084,641]],"region":{"top_left_x":1084,"top_left_y":578,"width":576,"height":64},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31d425ca6ba747ba8278bbec79e212ce","type":"table_spanning_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","children_ids":["76a947b5f7244647a0193ed87c467e15"],"text":"","text_display":"PPD","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1},{"cnt":[[1141,595],[1223,595],[1223,633],[1141,633]],"region":{"top_left_x":1141,"top_left_y":594,"width":83,"height":40},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76a947b5f7244647a0193ed87c467e15","type":"simple_cell","conversion_output":false,"parent_id":"31d425ca6ba747ba8278bbec79e212ce","text":"PPD","text_display":"PPD","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[260,660],[770,660],[770,739],[260,739]],"region":{"top_left_x":260,"top_left_y":660,"width":511,"height":80},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3120fd19995409cbc9867674a7c6498","type":"table_spanning_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"","text_display":"","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":2},{"cnt":[[268,748],[424,748],[424,794],[268,794]],"region":{"top_left_x":268,"top_left_y":747,"width":156,"height":47},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b713d5ba5c6647b68d44e82119b7277a","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"Signature","text_display":"Signature","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1087,748],[1373,748],[1373,794],[1087,794]],"region":{"top_left_x":1086,"top_left_y":747,"width":288,"height":47},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"766a1ca01fa845e0b017b09b200c59d1","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"Date of Signature","text_display":"Date of Signature","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,808],[653,808],[653,859],[263,859]],"region":{"top_left_x":262,"top_left_y":807,"width":392,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1501708df0ed45e985e34b2b7e55e577","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"Name, academic degree","text_display":"Name, academic degree","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[689,791],[765,791],[765,829],[689,829]],"region":{"top_left_x":688,"top_left_y":791,"width":77,"height":39},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e637f0d8d94d467db3559a2d96be3de1","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"PPD","text_display":"PPD","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[268,879],[418,879],[418,919],[268,919]],"region":{"top_left_x":268,"top_left_y":878,"width":151,"height":42},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34224c4c8c6145e1854d7162423564cf","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"Function","text_display":"Function","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.98291015625,"confidence_rate":0.9986749125109371},{"cnt":[[268,988],[440,988],[440,1029],[268,1029]],"region":{"top_left_x":268,"top_left_y":987,"width":173,"height":42},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a08ac84373df484f9b3a379372c8709a","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"Institution","text_display":"Institution","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[268,1053],[408,1053],[408,1094],[268,1094]],"region":{"top_left_x":268,"top_left_y":1053,"width":140,"height":42},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e94314e4384b4a75abca0ee357928afe","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"Address","text_display":"Address","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[268,1165],[577,1165],[577,1214],[268,1214]],"region":{"top_left_x":268,"top_left_y":1165,"width":309,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4193d2f259bb4c81a1f404784acd0884","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"Telephone number","text_display":"Telephone number","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[268,1231],[473,1231],[473,1269],[268,1269]],"region":{"top_left_x":268,"top_left_y":1230,"width":205,"height":39},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a3ab5564acb40efa1e2ba70bf2fd553","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"Fax number","text_display":"Fax number","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[268,1296],[517,1296],[517,1340],[268,1340]],"region":{"top_left_x":268,"top_left_y":1296,"width":249,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3604e21b94d347f9bf946b0d2158faba","type":"simple_cell","conversion_output":false,"parent_id":"e3ecb45997414ccaa5b4b8cc4b9ef87c","text":"E-mail address","text_display":"E-mail address","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.999974295041004},{"cnt":[[271,2432],[458,2432],[458,2469],[271,2469]],"region":{"top_left_x":270,"top_left_y":2432,"width":188,"height":37},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f57c82fe340549ca930d30dd9da98a9d","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999712709716212},{"cnt":[[275,2466],[410,2466],[410,2507],[275,2507]],"region":{"top_left_x":275,"top_left_y":2466,"width":136,"height":42},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"43b03d1e37fd49aeb38da75909a14e03","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1482,2458],[1560,2458],[1560,2494],[1482,2494]],"region":{"top_left_x":1482,"top_left_y":2457,"width":78,"height":38},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"00f483aba2c641eb8d5cc88e8585d73a","type":"page_info","conversion_output":false,"text":"4/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-005","page":5,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff684349c94647f7ae5d8453651e0dfe","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb30aea70c5841a783e2f3c0488ee85c","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"009026da9cb844708214a89e90360605","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,316],[930,316],[930,380],[236,380]],"region":{"top_left_x":236,"top_left_y":315,"width":695,"height":66},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a833677f94d475e81a950be19c00b30","type":"section_header","conversion_output":false,"children_ids":["77370f3a3b72412b91956090e44864c6"],"text":"","text_display":""},{"cnt":[[245,322],[926,322],[926,376],[245,376]],"region":{"top_left_x":244,"top_left_y":322,"width":682,"height":54},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77370f3a3b72412b91956090e44864c6","type":"text","conversion_output":true,"parent_id":"7a833677f94d475e81a950be19c00b30","text":"Further Sponsor Responsible Persons","text_display":"\n\n\\section*{Further Sponsor Responsible Persons}","confidence":1,"confidence_rate":1},{"cnt":[[245,408],[617,408],[617,458],[245,458]],"region":{"top_left_x":244,"top_left_y":408,"width":373,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4410ab53f6784cf5b5b162d85ac846ee","type":"text","conversion_output":true,"text":"Medical Responsible:","text_display":"\n\nMedical Responsible:","confidence":1,"confidence_rate":1},{"cnt":[[245,453],[329,453],[329,492],[245,492]],"region":{"top_left_x":244,"top_left_y":453,"width":85,"height":39},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e2fb25806a74bc8a92dbc94e5b72f64","type":"text","conversion_output":true,"text":"PPD","text_display":"\nPPD","confidence":1,"confidence_rate":1},{"cnt":[[243,498],[329,498],[329,539],[243,539]],"region":{"top_left_x":242,"top_left_y":498,"width":87,"height":42},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e36d867b2434beaa58a709030d8ebe6","type":"text","conversion_output":true,"text":"PPD","text_display":"\nPPD","confidence":1,"confidence_rate":1},{"cnt":[[245,556],[561,556],[561,604],[245,604]],"region":{"top_left_x":244,"top_left_y":556,"width":317,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcb610c8f1bd48ea803cc66df145ddf2","type":"text","conversion_output":true,"text":"EMD Serono, Inc.","text_display":"\nEMD Serono, Inc.","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1021,602],[1021,651],[245,651]],"region":{"top_left_x":244,"top_left_y":601,"width":777,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15edf117d2314137b848b4629cf17b4a","type":"text","conversion_output":true,"text":"One Technology Place, Rockland, MA 02370","text_display":"\nOne Technology Place, Rockland, MA 02370","confidence":1,"confidence_rate":1},{"cnt":[[245,647],[795,647],[795,700],[245,700]],"region":{"top_left_x":244,"top_left_y":646,"width":551,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f5daee0bd9a4d2c81ea20434cb43266","type":"text","conversion_output":true,"text":"Tel: PPD ; Fax: PPD","text_display":"\nTel: PPD ; Fax: PPD","confidence":0.9289996409788728,"confidence_rate":0.9969360814652509},{"cnt":[[243,692],[329,692],[329,733],[243,733]],"region":{"top_left_x":242,"top_left_y":691,"width":87,"height":42},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"934eebc54afe4094b227096fd99ba538","type":"text","conversion_output":true,"text":"PPD","text_display":"\nPPD","confidence":1,"confidence_rate":1},{"cnt":[[245,791],[505,791],[505,834],[245,834]],"region":{"top_left_x":244,"top_left_y":790,"width":261,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1765fe24863a452cb0903d96f3e5afd8","type":"text","conversion_output":true,"text":"Biostatistician:","text_display":"\n\nBiostatistician:","confidence":1,"confidence_rate":1},{"cnt":[[245,831],[329,831],[329,870],[245,870]],"region":{"top_left_x":244,"top_left_y":831,"width":85,"height":40},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f4f76f9de784eaf9eabb87398fd7c39","type":"text","conversion_output":true,"text":"PPD","text_display":"\nPPD","confidence":1,"confidence_rate":1},{"cnt":[[245,877],[329,877],[329,917],[245,917]],"region":{"top_left_x":244,"top_left_y":876,"width":85,"height":42},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ae3451706b64d7a9f4191a6d9e2ca3c","type":"text","conversion_output":true,"text":"PPD","text_display":"\nPPD","confidence":1,"confidence_rate":1},{"cnt":[[245,932],[750,932],[750,978],[245,978]],"region":{"top_left_x":244,"top_left_y":932,"width":506,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13a8e072279d43ae91b87e31d5561366","type":"text","conversion_output":true,"text":"Merck Serono S.A. - Geneva","text_display":"\nMerck Serono S.A. - Geneva","confidence":1,"confidence_rate":1},{"cnt":[[245,980],[1044,980],[1044,1027],[245,1027]],"region":{"top_left_x":244,"top_left_y":979,"width":801,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d7d7a8a670649e1a6596da0c2dd6752","type":"text","conversion_output":true,"text":"9 chemin des Mines, 1202 Geneva Switzerland","text_display":"\n9 chemin des Mines, 1202 Geneva Switzerland","confidence":1,"confidence_rate":1},{"cnt":[[245,1023],[804,1023],[804,1076],[245,1076]],"region":{"top_left_x":244,"top_left_y":1022,"width":560,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b45276b59a0244bc94ee965205d89af2","type":"text","conversion_output":true,"text":"Tel.: PPD ; Fax: PPD","text_display":"\nTel.: PPD ; Fax: PPD","confidence":0.9800411962537453,"confidence_rate":0.9991938982264447},{"cnt":[[245,1072],[466,1072],[466,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1072,"width":223,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1584464e105344b9a40a6ce3a34e123a","type":"text","conversion_output":true,"text":"e-mail: PPD","text_display":"\ne-mail: PPD","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[440,2509],[440,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":197,"height":37},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b4dc11427334e1ab74de4c97d3f500c","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2522],[1605,2522],[1605,2563],[1521,2563]],"region":{"top_left_x":1521,"top_left_y":2522,"width":84,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"757a3d39195246f383781e346dac60f3","type":"page_info","conversion_output":false,"text":"5/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[460,2544],[460,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2543,"width":216,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46af5c918b054586ace60921317ae9fa","type":"page_info","conversion_output":false,"text":"Object No.CCl","text_display":"","confidence":0.5627424130216241,"confidence_rate":0.9685639795646542}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-006","page":6,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16e4c24901fb4e4694365e2ebed0a5ac","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c2fb24e274b450db794987a1c1d9794","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e57a63fe003f4727a1775e83ae3821d5","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,318],[836,318],[836,380],[241,380]],"region":{"top_left_x":240,"top_left_y":317,"width":596,"height":64},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"148b3339f4864bfa88561f9c6fb777ee","type":"section_header","conversion_output":false,"children_ids":["33e8695bb751498b8bc9297bb5965c11"],"text":"","text_display":""},{"cnt":[[245,322],[829,322],[829,376],[245,376]],"region":{"top_left_x":244,"top_left_y":322,"width":586,"height":54},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33e8695bb751498b8bc9297bb5965c11","type":"text","conversion_output":true,"parent_id":"148b3339f4864bfa88561f9c6fb777ee","text":"Principal Investigator Signature","text_display":"\n\n\\section*{Principal Investigator Signature}","confidence":1,"confidence_rate":1},{"cnt":[[260,389],[887,389],[887,818],[260,818]],"region":{"top_left_x":260,"top_left_y":389,"width":627,"height":429},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce7d9364e959400990e7870fc15bc239","type":"column","conversion_output":false,"children_ids":["210ec8f74aa34bc48befeb3d2ba4634f","4666d7e4988542b6b32fc0fa153f82c3","6d69d0eba3fa4b518e9a214e6d3b8dcd"],"text":"","text_display":""},{"cnt":[[262,391],[445,391],[445,436],[262,436]],"region":{"top_left_x":262,"top_left_y":391,"width":183,"height":46},"line":7,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"210ec8f74aa34bc48befeb3d2ba4634f","type":"text","conversion_output":true,"parent_id":"ce7d9364e959400990e7870fc15bc239","text":"Trial Title","text_display":"\n\nTrial Title","confidence":1,"confidence_rate":1},{"cnt":[[262,696],[576,696],[576,746],[262,746]],"region":{"top_left_x":262,"top_left_y":696,"width":314,"height":50},"line":8,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4666d7e4988542b6b32fc0fa153f82c3","type":"text","conversion_output":true,"parent_id":"ce7d9364e959400990e7870fc15bc239","text":"EudraCT Number","text_display":"\n\nEudraCT Number","confidence":0.99951171875,"confidence_rate":0.999974295041004},{"cnt":[[262,767],[883,767],[883,814],[262,814]],"region":{"top_left_x":262,"top_left_y":766,"width":622,"height":49},"line":9,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d69d0eba3fa4b518e9a214e6d3b8dcd","type":"text","conversion_output":true,"parent_id":"ce7d9364e959400990e7870fc15bc239","text":"Clinical Trial Protocol Version/Date","text_display":"\nClinical Trial Protocol Version/Date","confidence":1,"confidence_rate":1},{"cnt":[[947,389],[1886,389],[1886,869],[947,869]],"region":{"top_left_x":947,"top_left_y":389,"width":939,"height":480},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42a4de24a8834835876d21f03e7b4b3d","type":"column","conversion_output":false,"children_ids":["080a70c921fa4f628f8b870b1bf6034f","f36ea4183de04be78e9a116347f2745c","c9cbdaba88984b34b93f427e92c251b7","0061ef39f2ab413eb2383b9b71c8d6de","ba553b579a0a4040900eff0400ceafd4","273f9b3aade740c9a801941cb6ff9acb","67a416caec8b48f49c6bc274d4f21bc3","7195a0aa79df4cf99e5cebb4ef84473b","6da392b633c44b3790411e12a2817de0"],"text":"","text_display":""},{"cnt":[[950,391],[1880,391],[1880,440],[950,440]],"region":{"top_left_x":949,"top_left_y":391,"width":931,"height":50},"line":11,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"080a70c921fa4f628f8b870b1bf6034f","type":"text","conversion_output":true,"parent_id":"42a4de24a8834835876d21f03e7b4b3d","text":"A multicenter, randomized, double-blind, placebo-","text_display":"\n\nA multicenter, randomized, double-blind, placebo","confidence":1,"confidence_rate":1},{"cnt":[[950,438],[1882,438],[1882,490],[950,490]],"region":{"top_left_x":949,"top_left_y":438,"width":934,"height":52},"line":12,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f36ea4183de04be78e9a116347f2745c","type":"text","conversion_output":true,"parent_id":"42a4de24a8834835876d21f03e7b4b3d","text":"controlled, parallel-group trial to investigate the","text_display":"controlled, parallel-group trial to investigate the","confidence":1,"confidence_rate":1},{"cnt":[[950,486],[1880,486],[1880,539],[950,539]],"region":{"top_left_x":949,"top_left_y":485,"width":931,"height":55},"line":13,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9cbdaba88984b34b93f427e92c251b7","type":"text","conversion_output":true,"parent_id":"42a4de24a8834835876d21f03e7b4b3d","text":"efficacy and safety of different intra-articular (i.a.)","text_display":" efficacy and safety of different intra-articular (i.a.)","confidence":0.9926926967455074,"confidence_rate":0.9998777719308954},{"cnt":[[950,535],[1880,535],[1880,587],[950,587]],"region":{"top_left_x":949,"top_left_y":534,"width":931,"height":53},"line":14,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0061ef39f2ab413eb2383b9b71c8d6de","type":"text","conversion_output":true,"parent_id":"42a4de24a8834835876d21f03e7b4b3d","text":"dosages of sprifermin in subjects with primary","text_display":" dosages of sprifermin in subjects with primary","confidence":1,"confidence_rate":1},{"cnt":[[950,580],[1880,580],[1880,634],[950,634]],"region":{"top_left_x":949,"top_left_y":580,"width":931,"height":54},"line":15,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba553b579a0a4040900eff0400ceafd4","type":"text","conversion_output":true,"parent_id":"42a4de24a8834835876d21f03e7b4b3d","text":"osteoarthritis of the knee (FORWARD)","text_display":" osteoarthritis of the knee (FORWARD)","confidence":1,"confidence_rate":1},{"cnt":[[950,629],[1287,629],[1287,681],[950,681]],"region":{"top_left_x":949,"top_left_y":629,"width":338,"height":53},"line":16,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"273f9b3aade740c9a801941cb6ff9acb","type":"text","conversion_output":true,"parent_id":"42a4de24a8834835876d21f03e7b4b3d","text":"(EMR700692_006)","text_display":" (EMR700692_006)","confidence":1,"confidence_rate":1},{"cnt":[[950,700],[1240,700],[1240,746],[950,746]],"region":{"top_left_x":949,"top_left_y":700,"width":291,"height":46},"line":17,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67a416caec8b48f49c6bc274d4f21bc3","type":"text","conversion_output":true,"parent_id":"42a4de24a8834835876d21f03e7b4b3d","text":"2011-003059-20","text_display":"\n\n2011-003059-20","confidence":1,"confidence_rate":1},{"cnt":[[950,767],[1880,767],[1880,819],[950,819]],"region":{"top_left_x":949,"top_left_y":766,"width":931,"height":53},"line":18,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7195a0aa79df4cf99e5cebb4ef84473b","type":"text","conversion_output":true,"parent_id":"42a4de24a8834835876d21f03e7b4b3d","text":"05 Mar 2013/ Version 4.0 (including Amendments 1","text_display":"\n05 Mar 2013/ Version 4.0 (including Amendments 1","confidence":1,"confidence_rate":1},{"cnt":[[950,816],[1068,816],[1068,866],[950,866]],"region":{"top_left_x":949,"top_left_y":816,"width":119,"height":50},"line":19,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6da392b633c44b3790411e12a2817de0","type":"text","conversion_output":true,"parent_id":"42a4de24a8834835876d21f03e7b4b3d","text":"and 2)","text_display":" and 2)","confidence":1,"confidence_rate":1},{"cnt":[[262,881],[535,881],[535,930],[262,930]],"region":{"top_left_x":262,"top_left_y":880,"width":273,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49bced235dd34424bc81f54dadc74628","type":"text","conversion_output":true,"text":"Center Number","text_display":"\n\nCenter Number","confidence":1,"confidence_rate":1},{"cnt":[[262,952],[638,952],[638,1003],[262,1003]],"region":{"top_left_x":262,"top_left_y":951,"width":377,"height":53},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"791140a5a8d7493a961ab757d6c4e3ec","type":"text","conversion_output":true,"text":"Principal Investigator","text_display":"\nPrincipal Investigator","confidence":1,"confidence_rate":1},{"cnt":[[245,1021],[1721,1021],[1721,1074],[245,1074]],"region":{"top_left_x":244,"top_left_y":1020,"width":1477,"height":55},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9904e34129bf4f26bca2d54a2ba67644","type":"text","conversion_output":true,"text":"I, the undersigned, am responsible for the conduct of the trial at this site and affirm that:","text_display":"\nI, the undersigned, am responsible for the conduct of the trial at this site and affirm that:","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,1091],[1882,1091],[1882,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1091,"width":1639,"height":55},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b4533e866ea4bff8ff9875ba937797a","type":"text","conversion_output":true,"text":"- I understand and will conduct the trial according to the clinical trial protocol, any approved","text_display":"\n- I understand and will conduct the trial according to the clinical trial protocol, any approved","confidence":1,"confidence_rate":1},{"cnt":[[292,1143],[1882,1143],[1882,1192],[292,1192]],"region":{"top_left_x":292,"top_left_y":1142,"width":1591,"height":51},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c0aba2487044d8aab2f8709398b6107","type":"text","conversion_output":true,"text":"protocol amendments, International Conference on Harmonization Good Clinical Practice","text_display":" protocol amendments, International Conference on Harmonization Good Clinical Practice","confidence":1,"confidence_rate":1},{"cnt":[[292,1190],[1798,1190],[1798,1242],[292,1242]],"region":{"top_left_x":292,"top_left_y":1190,"width":1507,"height":52},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45136ee5656d410e8d88af0c1f552d65","type":"text","conversion_output":true,"text":"(ICH Topic E6 GCP) and all applicable Health Authority requirements and national laws.","text_display":" (ICH Topic E6 GCP) and all applicable Health Authority requirements and national laws.","confidence":1,"confidence_rate":1},{"cnt":[[245,1259],[1880,1259],[1880,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1258,"width":1636,"height":55},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"721ded2652de49458bea021287e04eb9","type":"text","conversion_output":true,"text":"- I will not deviate from the clinical trial protocol without prior written permission from the","text_display":"\n- I will not deviate from the clinical trial protocol without prior written permission from the","confidence":1,"confidence_rate":1},{"cnt":[[294,1311],[1882,1311],[1882,1360],[294,1360]],"region":{"top_left_x":294,"top_left_y":1310,"width":1589,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dd599cdbe7d416caabe6d71a0570f57","type":"text","conversion_output":true,"text":"Sponsor and prior review and written approval from the Institutional Review Board or","text_display":" Sponsor and prior review and written approval from the Institutional Review Board or","confidence":1,"confidence_rate":1},{"cnt":[[292,1358],[1880,1358],[1880,1407],[292,1407]],"region":{"top_left_x":292,"top_left_y":1357,"width":1588,"height":51},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"931be1a40e324cc39e84769690d5357f","type":"text","conversion_output":true,"text":"Independent Ethics Committee, except where necessary to prevent immediate danger to the","text_display":" Independent Ethics Committee, except where necessary to prevent immediate danger to the","confidence":1,"confidence_rate":1},{"cnt":[[292,1405],[432,1405],[432,1457],[292,1457]],"region":{"top_left_x":292,"top_left_y":1405,"width":140,"height":52},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cd61866e1d14743a59979b1ec676f30","type":"text","conversion_output":true,"text":"subject.","text_display":" subject.","confidence":1,"confidence_rate":1},{"cnt":[[245,1474],[1880,1474],[1880,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1473,"width":1636,"height":55},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79ad021da8a34f2fa30a4eeacb69db64","type":"text","conversion_output":true,"text":"- I understand that some Health Authorities require the Sponsors of clinical trials to obtain and","text_display":"\n- I understand that some Health Authorities require the Sponsors of clinical trials to obtain and","confidence":1,"confidence_rate":1},{"cnt":[[294,1525],[1882,1525],[1882,1577],[294,1577]],"region":{"top_left_x":294,"top_left_y":1525,"width":1589,"height":52},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24a6512d4f3b489fa5fd2430f2a00244","type":"text","conversion_output":true,"text":"supply, when required, details about the Investigators' ownership interests in the Sponsor or","text_display":" supply, when required, details about the Investigators' ownership interests in the Sponsor or","confidence":1,"confidence_rate":1},{"cnt":[[294,1573],[1880,1573],[1880,1624],[294,1624]],"region":{"top_left_x":294,"top_left_y":1572,"width":1586,"height":53},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a71893f122140e2b2bc9363a3c4e252","type":"text","conversion_output":true,"text":"Investigational Medicinal Product and information regarding any financial ties with the","text_display":" Investigational Medicinal Product and information regarding any financial ties with the","confidence":1,"confidence_rate":1},{"cnt":[[294,1620],[1884,1620],[1884,1674],[294,1674]],"region":{"top_left_x":294,"top_left_y":1619,"width":1591,"height":55},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a9f2324d7fb401ca0410cb8db398f68","type":"text","conversion_output":true,"text":"Sponsor. The Sponsor will use any such information that is collected solely for the purpose of","text_display":" Sponsor. The Sponsor will use any such information that is collected solely for the purpose of","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[294,1669],[1882,1669],[1882,1721],[294,1721]],"region":{"top_left_x":294,"top_left_y":1669,"width":1589,"height":52},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5709c58e9cc48adaa05d2fe9512685b","type":"text","conversion_output":true,"text":"complying with the regulatory requirements. I therefore agree to supply the Sponsor with any","text_display":" complying with the regulatory requirements. I therefore agree to supply the Sponsor with any","confidence":1,"confidence_rate":1},{"cnt":[[294,1714],[1882,1714],[1882,1768],[294,1768]],"region":{"top_left_x":294,"top_left_y":1714,"width":1589,"height":55},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3670df4094b24a51ad97e4bed9974cf7","type":"text","conversion_output":true,"text":"necessary information regarding ownership interest and financial ties (including those of my","text_display":" necessary information regarding ownership interest and financial ties (including those of my","confidence":1,"confidence_rate":1},{"cnt":[[292,1766],[1454,1766],[1454,1818],[292,1818]],"region":{"top_left_x":292,"top_left_y":1766,"width":1163,"height":52},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ac97b42e8674f5e869ce3c18bd794c4","type":"text","conversion_output":true,"text":"spouse and dependent children), and to provide updates as necessary.","text_display":" spouse and dependent children), and to provide updates as necessary.","confidence":1,"confidence_rate":1},{"cnt":[[241,1922],[660,1922],[660,2456],[241,2456]],"region":{"top_left_x":241,"top_left_y":1922,"width":419,"height":534},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a854c1f56a1475282e0aeeed753e407","type":"column","conversion_output":false,"children_ids":["5e693bfd4eec410ba1190db9dffd7849","c824a60fd0954c8f913cc4f0d41641ec","89195042779042218e678c8ec3f6a36f","b6fd547675cb48b39292255d3731607a","48ffd51b83dd46dc98b620fa9067df11","945c4ec5643d451d81587a14e79be5ab","abfc1dae609f47fe94c0811f2e23c95d","4a89af15fa56482eacc065aa0139bee5"],"text":"","text_display":""},{"cnt":[[245,1925],[415,1925],[415,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1925,"width":171,"height":50},"line":38,"column":3,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e693bfd4eec410ba1190db9dffd7849","type":"text","conversion_output":true,"parent_id":"3a854c1f56a1475282e0aeeed753e407","text":"Signature","text_display":"\n\nSignature","confidence":1,"confidence_rate":1},{"cnt":[[245,1989],[655,1989],[655,2043],[245,2043]],"region":{"top_left_x":244,"top_left_y":1989,"width":412,"height":55},"line":39,"column":3,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c824a60fd0954c8f913cc4f0d41641ec","type":"text","conversion_output":true,"parent_id":"3a854c1f56a1475282e0aeeed753e407","text":"Name, academic degree","text_display":"\nName, academic degree","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[406,2058],[406,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":163,"height":50},"line":40,"column":3,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89195042779042218e678c8ec3f6a36f","type":"text","conversion_output":true,"parent_id":"3a854c1f56a1475282e0aeeed753e407","text":"Function","text_display":"\nFunction","confidence":1,"confidence_rate":1},{"cnt":[[245,2127],[428,2127],[428,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2126,"width":184,"height":51},"line":41,"column":3,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6fd547675cb48b39292255d3731607a","type":"text","conversion_output":true,"parent_id":"3a854c1f56a1475282e0aeeed753e407","text":"Institution","text_display":"\nInstitution","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[391,2196],[391,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2195,"width":148,"height":51},"line":42,"column":3,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48ffd51b83dd46dc98b620fa9067df11","type":"text","conversion_output":true,"parent_id":"3a854c1f56a1475282e0aeeed753e407","text":"Address","text_display":"\nAddress","confidence":1,"confidence_rate":1},{"cnt":[[245,2264],[569,2264],[569,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2264,"width":326,"height":55},"line":43,"column":3,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"945c4ec5643d451d81587a14e79be5ab","type":"text","conversion_output":true,"parent_id":"3a854c1f56a1475282e0aeeed753e407","text":"Telephone number","text_display":"\nTelephone number","confidence":1,"confidence_rate":1},{"cnt":[[245,2333],[458,2333],[458,2383],[245,2383]],"region":{"top_left_x":244,"top_left_y":2333,"width":214,"height":50},"line":44,"column":3,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abfc1dae609f47fe94c0811f2e23c95d","type":"text","conversion_output":true,"parent_id":"3a854c1f56a1475282e0aeeed753e407","text":"Fax number","text_display":"\nFax number","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[505,2402],[505,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":261,"height":51},"line":45,"column":3,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a89af15fa56482eacc065aa0139bee5","type":"text","conversion_output":true,"parent_id":"3a854c1f56a1475282e0aeeed753e407","text":"E-mail address","text_display":"\nE-mail address","confidence":1,"confidence_rate":1},{"cnt":[[1104,1921],[1412,1921],[1412,1979],[1104,1979]],"region":{"top_left_x":1104,"top_left_y":1920,"width":308,"height":59},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e7d44de39da4c8badf57363d7412baa","type":"text","conversion_output":true,"text":"Date of Signature","text_display":"\n\nDate of Signature","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-007","page":7,"lines":[{"cnt":[[245,129],[434,129],[434,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":190,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9f47a5c3aaa4631841deb9f0d05d4d0","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfb1598f5b8a4558b480f4a12b3888d4","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"944b265f471741519ad8f00603d15711","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[217,314],[1777,314],[1777,2501],[217,2501]],"region":{"top_left_x":216,"top_left_y":313,"width":1561,"height":2188},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71236384864042418ee0850da1257684","type":"table_of_contents_container","conversion_output":false,"children_ids":["46830bd332a242a6afdd60431d0c7f1a","e6d517af1c2748cb88bb73e96f833a2a","3c9a50ff5b6542ffb60a17fd87defa32","2eec6957506345bc91941a2582103b51","5e2ed0546e1243208e2a6e1bce456be3","c83ca88974f04cc2afadf3c87b11d442","246980eee48a4764a68241b6e980b342","9c3aaab5a0da4fa3b70673997deb41f7","dfafa9333c0847318664990a85138d17","95d390178c464c648ccab68b48b8ad60","491fe5bcc6f040659e8fb2efecccb31e","6018bcb05c9847a9b026efe43158d5e1","e14fe02dee3c4fc3a9584cc3f26d0581","381cb88595ba4a7696ac2e1b24c1fb3c","bae04add0eab49efa5f70bc64621c066","5e9af3e5a1e44451b11a08511a83fb02","e728dce9965c4e49b102881d329b3fb6","339e58ebbece47c89cff16866cfc0b6d","bb5dd71e48714313826626b442a364bb","662b0cf03b53461a8ae011db72582be7","4173e18152e04c70afb9ad78a52973be","3dbd823a04654b16ae95cbcdb97e2363","632107bf5fd64c0eaa70b76dc8daa66a","0668f94afe674062b78f97a5fdf03874","1075a4050fff46449f7d0452a641c7d8","a7567344acf2402c990d8d45ce24a45f","ced45fd30a4841a4afe618ab4748b000","082edccc95924a0eae752573493460ef","ce3851a7cc3a49fea78d5fb8da358edf","71a908736bb04a72929f3689bccec9a2","af6658df1aac4016aa8fcc95c7876ad5"],"text":"","text_display":""},{"cnt":[[241,320],[632,320],[632,380],[241,380]],"region":{"top_left_x":240,"top_left_y":320,"width":392,"height":61},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46830bd332a242a6afdd60431d0c7f1a","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["af853f548d884622935272253ec6bcad"],"text":"","text_display":""},{"cnt":[[245,327],[625,327],[625,374],[245,374]],"region":{"top_left_x":244,"top_left_y":326,"width":382,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af853f548d884622935272253ec6bcad","type":"table_of_contents_item","conversion_output":true,"parent_id":"46830bd332a242a6afdd60431d0c7f1a","text":"Table of Contents","text_display":"\nTable of Contents","confidence":0.99951171875,"confidence_rate":0.9999778002237774},{"cnt":[[241,395],[1760,395],[1760,453],[241,453]],"region":{"top_left_x":240,"top_left_y":395,"width":1520,"height":59},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6d517af1c2748cb88bb73e96f833a2a","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["ebfd066f843441799256d6e13febbb2f","ece9207a51554b3ab9774a6dc26f5e92"],"text":"","text_display":""},{"cnt":[[245,400],[505,400],[505,449],[245,449]],"region":{"top_left_x":244,"top_left_y":399,"width":261,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebfd066f843441799256d6e13febbb2f","type":"table_of_contents_item","conversion_output":true,"parent_id":"e6d517af1c2748cb88bb73e96f833a2a","text":"Signature Page","text_display":"\nSignature Page","confidence":1,"confidence_rate":1},{"cnt":[[1725,397],[1764,397],[1764,443],[1725,443]],"region":{"top_left_x":1725,"top_left_y":397,"width":39,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ece9207a51554b3ab9774a6dc26f5e92","type":"table_of_contents_number","conversion_output":true,"parent_id":"e6d517af1c2748cb88bb73e96f833a2a","text":"3","text_display":" ..... 3","confidence":1,"confidence_rate":1},{"cnt":[[241,464],[1760,464],[1760,518],[241,518]],"region":{"top_left_x":240,"top_left_y":464,"width":1520,"height":54},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c9a50ff5b6542ffb60a17fd87defa32","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["bfd1c2e4637a4e9eae7cbb70570d55a8","0a7c1c61799c4d25b4a538a1bdc209b1"],"text":"","text_display":""},{"cnt":[[245,468],[552,468],[552,513],[245,513]],"region":{"top_left_x":244,"top_left_y":468,"width":309,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfd1c2e4637a4e9eae7cbb70570d55a8","type":"table_of_contents_item","conversion_output":true,"parent_id":"3c9a50ff5b6542ffb60a17fd87defa32","text":"Table of Contents","text_display":"\nTable of Contents","confidence":0.9990234375,"confidence_rate":0.9999555900930661},{"cnt":[[1727,466],[1764,466],[1764,511],[1727,511]],"region":{"top_left_x":1727,"top_left_y":466,"width":37,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a7c1c61799c4d25b4a538a1bdc209b1","type":"table_of_contents_number","conversion_output":true,"parent_id":"3c9a50ff5b6542ffb60a17fd87defa32","text":"7","text_display":" ..... 7","confidence":1,"confidence_rate":1},{"cnt":[[241,533],[1757,533],[1757,587],[241,587]],"region":{"top_left_x":240,"top_left_y":532,"width":1518,"height":55},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2eec6957506345bc91941a2582103b51","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["4f67ba3668f2459ba413c3f59a16d32f","82b2b682d8e64ac094d680cccc5d1f75"],"text":"","text_display":""},{"cnt":[[245,537],[518,537],[518,582],[245,582]],"region":{"top_left_x":244,"top_left_y":537,"width":274,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f67ba3668f2459ba413c3f59a16d32f","type":"table_of_contents_item","conversion_output":true,"parent_id":"2eec6957506345bc91941a2582103b51","text":"Table of Tables","text_display":"\nTable of Tables","confidence":1,"confidence_rate":1},{"cnt":[[1708,537],[1753,537],[1753,580],[1708,580]],"region":{"top_left_x":1708,"top_left_y":537,"width":46,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82b2b682d8e64ac094d680cccc5d1f75","type":"table_of_contents_number","conversion_output":true,"parent_id":"2eec6957506345bc91941a2582103b51","text":"11","text_display":" ..... 11","confidence":1,"confidence_rate":1},{"cnt":[[241,602],[1757,602],[1757,660],[241,660]],"region":{"top_left_x":240,"top_left_y":601,"width":1518,"height":59},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e2ed0546e1243208e2a6e1bce456be3","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["1c72f1faf5ed4953b4fa4a1de3e46259","cc60568d84294124b5eb9acfed6fc461"],"text":"","text_display":""},{"cnt":[[245,606],[531,606],[531,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":287,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c72f1faf5ed4953b4fa4a1de3e46259","type":"table_of_contents_item","conversion_output":true,"parent_id":"5e2ed0546e1243208e2a6e1bce456be3","text":"Table of Figures","text_display":"\nTable of Figures","confidence":1,"confidence_rate":1},{"cnt":[[1706,606],[1753,606],[1753,649],[1706,649]],"region":{"top_left_x":1705,"top_left_y":605,"width":49,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc60568d84294124b5eb9acfed6fc461","type":"table_of_contents_number","conversion_output":true,"parent_id":"5e2ed0546e1243208e2a6e1bce456be3","text":"11","text_display":" ..... 11","confidence":1,"confidence_rate":1},{"cnt":[[241,670],[1760,670],[1760,724],[241,724]],"region":{"top_left_x":240,"top_left_y":670,"width":1520,"height":55},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c83ca88974f04cc2afadf3c87b11d442","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["75d52a7bbe8d42be9cab103feb86df55","fd9487e771114de9a45dc2ef92fb19b5"],"text":"","text_display":""},{"cnt":[[245,675],[612,675],[612,720],[245,720]],"region":{"top_left_x":244,"top_left_y":674,"width":369,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75d52a7bbe8d42be9cab103feb86df55","type":"table_of_contents_item","conversion_output":true,"parent_id":"c83ca88974f04cc2afadf3c87b11d442","text":"List of Abbreviations","text_display":"\nList of Abbreviations","confidence":0.8061337110120803,"confidence_rate":0.9917455773236832},{"cnt":[[1706,675],[1757,675],[1757,718],[1706,718]],"region":{"top_left_x":1705,"top_left_y":674,"width":53,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd9487e771114de9a45dc2ef92fb19b5","type":"table_of_contents_number","conversion_output":true,"parent_id":"c83ca88974f04cc2afadf3c87b11d442","text":"12","text_display":" ..... 12","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[1760,739],[1760,797],[245,797]],"region":{"top_left_x":244,"top_left_y":739,"width":1516,"height":59},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"246980eee48a4764a68241b6e980b342","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["e68a04d4df324868b53accfb4ef9f476","b1131814fc024e1ca2cea2980bff7b3d"],"text":"","text_display":""},{"cnt":[[249,743],[728,743],[728,793],[249,793]],"region":{"top_left_x":249,"top_left_y":743,"width":480,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e68a04d4df324868b53accfb4ef9f476","type":"table_of_contents_item","conversion_output":true,"parent_id":"246980eee48a4764a68241b6e980b342","text":"1 Synopsis","text_display":"\n1 Synopsis","confidence":1,"confidence_rate":1},{"cnt":[[1706,743],[1757,743],[1757,786],[1706,786]],"region":{"top_left_x":1705,"top_left_y":743,"width":53,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1131814fc024e1ca2cea2980bff7b3d","type":"table_of_contents_number","conversion_output":true,"parent_id":"246980eee48a4764a68241b6e980b342","text":"17","text_display":" ..... 17","confidence":1,"confidence_rate":1},{"cnt":[[243,808],[1760,808],[1760,866],[243,866]],"region":{"top_left_x":242,"top_left_y":807,"width":1518,"height":59},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c3aaab5a0da4fa3b70673997deb41f7","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["88c4765d7b8f4bfbb37af63589b2f226","8ea765db12be482db3e94b3ea89b3dd3"],"text":"","text_display":""},{"cnt":[[245,812],[1540,812],[1540,877],[245,877]],"region":{"top_left_x":244,"top_left_y":812,"width":1297,"height":65},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88c4765d7b8f4bfbb37af63589b2f226","type":"table_of_contents_item","conversion_output":true,"parent_id":"9c3aaab5a0da4fa3b70673997deb41f7","text":"2 Sponsor, Investigators and Trial Administrative Structure","text_display":"\n2 Sponsor, Investigators and Trial Administrative Structure","confidence":0.99951171875,"confidence_rate":0.9999922476411908},{"cnt":[[1717,812],[1764,812],[1764,855],[1717,855]],"region":{"top_left_x":1716,"top_left_y":812,"width":48,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ea765db12be482db3e94b3ea89b3dd3","type":"table_of_contents_number","conversion_output":true,"parent_id":"9c3aaab5a0da4fa3b70673997deb41f7","text":"26","text_display":" ..... 26","confidence":1,"confidence_rate":1},{"cnt":[[243,877],[1760,877],[1760,935],[243,935]],"region":{"top_left_x":242,"top_left_y":876,"width":1518,"height":59},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dfafa9333c0847318664990a85138d17","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["54cf8a045cfb441680374c819b4351e3","d33fc41eb6634489b44a48ef47dafd93","a1bc3c08c6a942f6b53324d8f89190a0"],"text":"","text_display":""},{"cnt":[[243,881],[275,881],[275,932],[243,932]],"region":{"top_left_x":242,"top_left_y":880,"width":33,"height":53},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54cf8a045cfb441680374c819b4351e3","type":"table_of_contents_item","conversion_output":true,"parent_id":"dfafa9333c0847318664990a85138d17","text":"3","text_display":"\n3","confidence":1,"confidence_rate":1},{"cnt":[[571,881],[995,881],[995,930],[571,930]],"region":{"top_left_x":571,"top_left_y":880,"width":424,"height":51},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d33fc41eb6634489b44a48ef47dafd93","type":"table_of_contents_item","conversion_output":true,"parent_id":"dfafa9333c0847318664990a85138d17","text":"Background Information","text_display":" Background Information","confidence":0.96533203125,"confidence_rate":0.998694069655762},{"cnt":[[1706,881],[1757,881],[1757,926],[1706,926]],"region":{"top_left_x":1705,"top_left_y":880,"width":53,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1bc3c08c6a942f6b53324d8f89190a0","type":"table_of_contents_number","conversion_output":true,"parent_id":"dfafa9333c0847318664990a85138d17","text":"27","text_display":" ..... 27","confidence":1,"confidence_rate":1},{"cnt":[[243,945],[1760,945],[1760,1003],[243,1003]],"region":{"top_left_x":242,"top_left_y":945,"width":1518,"height":59},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95d390178c464c648ccab68b48b8ad60","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["c681a195aa6e4d939ca305adbec367c5","10dd18ee10e84539aba19dc8d0255d9c","9ab270ab5f4044168f88172fb6d80187"],"text":"","text_display":""},{"cnt":[[243,950],[279,950],[279,995],[243,995]],"region":{"top_left_x":242,"top_left_y":949,"width":38,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c681a195aa6e4d939ca305adbec367c5","type":"table_of_contents_item","conversion_output":true,"parent_id":"95d390178c464c648ccab68b48b8ad60","text":"4","text_display":"\n4","confidence":1,"confidence_rate":1},{"cnt":[[571,950],[849,950],[849,999],[571,999]],"region":{"top_left_x":571,"top_left_y":949,"width":278,"height":51},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10dd18ee10e84539aba19dc8d0255d9c","type":"table_of_contents_item","conversion_output":true,"parent_id":"95d390178c464c648ccab68b48b8ad60","text":"Trial Objectives","text_display":" Trial Objectives","confidence":1,"confidence_rate":1},{"cnt":[[1706,950],[1757,950],[1757,995],[1706,995]],"region":{"top_left_x":1705,"top_left_y":949,"width":53,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ab270ab5f4044168f88172fb6d80187","type":"table_of_contents_number","conversion_output":true,"parent_id":"95d390178c464c648ccab68b48b8ad60","text":"30","text_display":" ..... 30","confidence":1,"confidence_rate":1},{"cnt":[[243,1014],[1755,1014],[1755,1072],[243,1072]],"region":{"top_left_x":242,"top_left_y":1014,"width":1514,"height":59},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"491fe5bcc6f040659e8fb2efecccb31e","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["a414fa0e738c40d596e37aa11dd88b53","ed9adad90bd14dccbe2dedef6f1535f4","eadb627594de4690b7daed801db3fbe5"],"text":"","text_display":""},{"cnt":[[243,1018],[279,1018],[279,1061],[243,1061]],"region":{"top_left_x":242,"top_left_y":1018,"width":38,"height":44},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a414fa0e738c40d596e37aa11dd88b53","type":"table_of_contents_item","conversion_output":true,"parent_id":"491fe5bcc6f040659e8fb2efecccb31e","text":"5","text_display":"\n5","confidence":1,"confidence_rate":1},{"cnt":[[571,1018],[913,1018],[913,1068],[571,1068]],"region":{"top_left_x":571,"top_left_y":1018,"width":343,"height":50},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed9adad90bd14dccbe2dedef6f1535f4","type":"table_of_contents_item","conversion_output":true,"parent_id":"491fe5bcc6f040659e8fb2efecccb31e","text":"Investigational Plan","text_display":" Investigational Plan","confidence":1,"confidence_rate":1},{"cnt":[[1706,1018],[1753,1018],[1753,1061],[1706,1061]],"region":{"top_left_x":1705,"top_left_y":1018,"width":49,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eadb627594de4690b7daed801db3fbe5","type":"table_of_contents_number","conversion_output":true,"parent_id":"491fe5bcc6f040659e8fb2efecccb31e","text":"31","text_display":" ..... 31","confidence":1,"confidence_rate":1},{"cnt":[[243,1083],[1757,1083],[1757,1141],[243,1141]],"region":{"top_left_x":242,"top_left_y":1082,"width":1516,"height":59},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6018bcb05c9847a9b026efe43158d5e1","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["bed5b58703c04a0e80d52d83fdd6f5d3","e704e96c03764b009a0fd23d73e10d7d","41bc2b928ee1482f87618068917e4ff8"],"text":"","text_display":""},{"cnt":[[247,1087],[305,1087],[305,1134],[247,1134]],"region":{"top_left_x":247,"top_left_y":1087,"width":59,"height":48},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bed5b58703c04a0e80d52d83fdd6f5d3","type":"table_of_contents_item","conversion_output":true,"parent_id":"6018bcb05c9847a9b026efe43158d5e1","text":"5.1","text_display":"\n5.1","confidence":1,"confidence_rate":1},{"cnt":[[571,1087],[1081,1087],[1081,1137],[571,1137]],"region":{"top_left_x":571,"top_left_y":1087,"width":510,"height":50},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e704e96c03764b009a0fd23d73e10d7d","type":"table_of_contents_item","conversion_output":true,"parent_id":"6018bcb05c9847a9b026efe43158d5e1","text":"Overall Trial Design and Plan","text_display":" Overall Trial Design and Plan","confidence":0.99951171875,"confidence_rate":0.9999856353826395},{"cnt":[[1706,1087],[1753,1087],[1753,1130],[1706,1130]],"region":{"top_left_x":1705,"top_left_y":1087,"width":49,"height":44},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41bc2b928ee1482f87618068917e4ff8","type":"table_of_contents_number","conversion_output":true,"parent_id":"6018bcb05c9847a9b026efe43158d5e1","text":"31","text_display":" ..... 31","confidence":1,"confidence_rate":1},{"cnt":[[243,1152],[1760,1152],[1760,1210],[243,1210]],"region":{"top_left_x":242,"top_left_y":1151,"width":1518,"height":59},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e14fe02dee3c4fc3a9584cc3f26d0581","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["68d18933eaed48b1b8f72d1527859111","fa3bd0e3f9c94ffeb9cb3c468b2a53db","861dd7d0a87040cd8a3e90044b692ebf"],"text":"","text_display":""},{"cnt":[[249,1156],[309,1156],[309,1201],[249,1201]],"region":{"top_left_x":249,"top_left_y":1155,"width":61,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68d18933eaed48b1b8f72d1527859111","type":"table_of_contents_item","conversion_output":true,"parent_id":"e14fe02dee3c4fc3a9584cc3f26d0581","text":"5.2","text_display":"\n5.2","confidence":1,"confidence_rate":1},{"cnt":[[571,1156],[1027,1156],[1027,1205],[571,1205]],"region":{"top_left_x":571,"top_left_y":1155,"width":456,"height":51},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa3bd0e3f9c94ffeb9cb3c468b2a53db","type":"table_of_contents_item","conversion_output":true,"parent_id":"e14fe02dee3c4fc3a9584cc3f26d0581","text":"Discussion of Trial Design","text_display":" Discussion of Trial Design","confidence":1,"confidence_rate":1},{"cnt":[[1706,1156],[1757,1156],[1757,1199],[1706,1199]],"region":{"top_left_x":1705,"top_left_y":1155,"width":53,"height":44},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"861dd7d0a87040cd8a3e90044b692ebf","type":"table_of_contents_number","conversion_output":true,"parent_id":"e14fe02dee3c4fc3a9584cc3f26d0581","text":"37","text_display":" ..... 37","confidence":1,"confidence_rate":1},{"cnt":[[243,1220],[1760,1220],[1760,1280],[243,1280]],"region":{"top_left_x":242,"top_left_y":1220,"width":1518,"height":61},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"381cb88595ba4a7696ac2e1b24c1fb3c","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["d2fad3936ac44d30936639a5c4a6359d","598a69f9d8004bd598f7ead7065358f6","8c384d0682db4d348ea3da8345ea4c96"],"text":"","text_display":""},{"cnt":[[249,1227],[333,1227],[333,1270],[249,1270]],"region":{"top_left_x":249,"top_left_y":1226,"width":85,"height":44},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2fad3936ac44d30936639a5c4a6359d","type":"table_of_contents_item","conversion_output":true,"parent_id":"381cb88595ba4a7696ac2e1b24c1fb3c","text":"5.2.1","text_display":"\n5.2.1","confidence":0.99951171875,"confidence_rate":0.9999511611428449},{"cnt":[[571,1225],[1119,1225],[1119,1274],[571,1274]],"region":{"top_left_x":571,"top_left_y":1224,"width":549,"height":51},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"598a69f9d8004bd598f7ead7065358f6","type":"table_of_contents_item","conversion_output":true,"parent_id":"381cb88595ba4a7696ac2e1b24c1fb3c","text":"Inclusion of Special Populations","text_display":" Inclusion of Special Populations","confidence":0.99560546875,"confidence_rate":0.999880974230482},{"cnt":[[1704,1225],[1757,1225],[1757,1268],[1704,1268]],"region":{"top_left_x":1703,"top_left_y":1224,"width":55,"height":44},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c384d0682db4d348ea3da8345ea4c96","type":"table_of_contents_number","conversion_output":true,"parent_id":"381cb88595ba4a7696ac2e1b24c1fb3c","text":"42","text_display":" ..... 42","confidence":1,"confidence_rate":1},{"cnt":[[243,1289],[1760,1289],[1760,1347],[243,1347]],"region":{"top_left_x":242,"top_left_y":1289,"width":1518,"height":59},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bae04add0eab49efa5f70bc64621c066","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["22ae73a60504404283514228951b2a25","6b63595f786e41eb8d10f25832991bb8","9f7c2746c64d4f5e85fa103b59d8dd67"],"text":"","text_display":""},{"cnt":[[249,1293],[305,1293],[305,1336],[249,1336]],"region":{"top_left_x":249,"top_left_y":1293,"width":57,"height":44},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22ae73a60504404283514228951b2a25","type":"table_of_contents_item","conversion_output":true,"parent_id":"bae04add0eab49efa5f70bc64621c066","text":"5.3","text_display":"\n5.3","confidence":1,"confidence_rate":1},{"cnt":[[571,1293],[1061,1293],[1061,1343],[571,1343]],"region":{"top_left_x":571,"top_left_y":1293,"width":491,"height":50},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b63595f786e41eb8d10f25832991bb8","type":"table_of_contents_item","conversion_output":true,"parent_id":"bae04add0eab49efa5f70bc64621c066","text":"Selection of Trial Population","text_display":" Selection of Trial Population","confidence":1,"confidence_rate":1},{"cnt":[[1704,1293],[1757,1293],[1757,1336],[1704,1336]],"region":{"top_left_x":1703,"top_left_y":1293,"width":55,"height":44},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f7c2746c64d4f5e85fa103b59d8dd67","type":"table_of_contents_number","conversion_output":true,"parent_id":"bae04add0eab49efa5f70bc64621c066","text":"42","text_display":" ..... 42","confidence":1,"confidence_rate":1},{"cnt":[[243,1358],[1760,1358],[1760,1412],[243,1412]],"region":{"top_left_x":242,"top_left_y":1357,"width":1518,"height":55},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e9af3e5a1e44451b11a08511a83fb02","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["712588eefa2b471898a03f6f9441829c","bcb2bfbb1dc54d678a0bef2e41156c85","caf6ec48cf8d43c7bf9dba74f25e7238"],"text":"","text_display":""},{"cnt":[[249,1362],[333,1362],[333,1405],[249,1405]],"region":{"top_left_x":249,"top_left_y":1362,"width":85,"height":44},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"712588eefa2b471898a03f6f9441829c","type":"table_of_contents_item","conversion_output":true,"parent_id":"5e9af3e5a1e44451b11a08511a83fb02","text":"5.3.1","text_display":"\n5.3.1","confidence":1,"confidence_rate":1},{"cnt":[[571,1362],[874,1362],[874,1405],[571,1405]],"region":{"top_left_x":571,"top_left_y":1362,"width":304,"height":44},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcb2bfbb1dc54d678a0bef2e41156c85","type":"table_of_contents_item","conversion_output":true,"parent_id":"5e9af3e5a1e44451b11a08511a83fb02","text":"Inclusion Criteria","text_display":" Inclusion Criteria","confidence":1,"confidence_rate":1},{"cnt":[[1702,1362],[1757,1362],[1757,1405],[1702,1405]],"region":{"top_left_x":1701,"top_left_y":1362,"width":57,"height":44},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"caf6ec48cf8d43c7bf9dba74f25e7238","type":"table_of_contents_number","conversion_output":true,"parent_id":"5e9af3e5a1e44451b11a08511a83fb02","text":"42","text_display":" ..... 42","confidence":1,"confidence_rate":1},{"cnt":[[243,1427],[1760,1427],[1760,1480],[243,1480]],"region":{"top_left_x":242,"top_left_y":1426,"width":1518,"height":55},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e728dce9965c4e49b102881d329b3fb6","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["e9e4b05fb183445cafb310c904bd9524","1944b722b3ca416c9503b3201f1eb069","ebe474d3f4234c548890b000bbeb64ce"],"text":"","text_display":""},{"cnt":[[249,1431],[337,1431],[337,1474],[249,1474]],"region":{"top_left_x":249,"top_left_y":1430,"width":89,"height":44},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9e4b05fb183445cafb310c904bd9524","type":"table_of_contents_item","conversion_output":true,"parent_id":"e728dce9965c4e49b102881d329b3fb6","text":"5.3.2","text_display":"\n5.3.2","confidence":1,"confidence_rate":1},{"cnt":[[571,1431],[883,1431],[883,1474],[571,1474]],"region":{"top_left_x":571,"top_left_y":1430,"width":313,"height":44},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1944b722b3ca416c9503b3201f1eb069","type":"table_of_contents_item","conversion_output":true,"parent_id":"e728dce9965c4e49b102881d329b3fb6","text":"Exclusion Criteria","text_display":" Exclusion Criteria","confidence":1,"confidence_rate":1},{"cnt":[[1704,1431],[1757,1431],[1757,1474],[1704,1474]],"region":{"top_left_x":1703,"top_left_y":1430,"width":55,"height":44},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebe474d3f4234c548890b000bbeb64ce","type":"table_of_contents_number","conversion_output":true,"parent_id":"e728dce9965c4e49b102881d329b3fb6","text":"43","text_display":" ..... 43","confidence":1,"confidence_rate":1},{"cnt":[[243,1495],[1760,1495],[1760,1549],[243,1549]],"region":{"top_left_x":242,"top_left_y":1495,"width":1518,"height":55},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"339e58ebbece47c89cff16866cfc0b6d","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["994b40c8d8ab43cd916b16da1f4787ac","dc181fdbeb9b4e0fb4fd62fcc6617535","a16b9c09d69b41649ac1bf67e7dbed2a"],"text":"","text_display":""},{"cnt":[[249,1500],[309,1500],[309,1543],[249,1543]],"region":{"top_left_x":249,"top_left_y":1499,"width":61,"height":44},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"994b40c8d8ab43cd916b16da1f4787ac","type":"table_of_contents_item","conversion_output":true,"parent_id":"339e58ebbece47c89cff16866cfc0b6d","text":"5.4","text_display":"\n5.4","confidence":1,"confidence_rate":1},{"cnt":[[571,1500],[1033,1500],[1033,1543],[571,1543]],"region":{"top_left_x":571,"top_left_y":1499,"width":463,"height":44},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc181fdbeb9b4e0fb4fd62fcc6617535","type":"table_of_contents_item","conversion_output":true,"parent_id":"339e58ebbece47c89cff16866cfc0b6d","text":"Criteria for Randomization","text_display":" Criteria for Randomization","confidence":1,"confidence_rate":1},{"cnt":[[1706,1500],[1757,1500],[1757,1543],[1706,1543]],"region":{"top_left_x":1705,"top_left_y":1499,"width":53,"height":44},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a16b9c09d69b41649ac1bf67e7dbed2a","type":"table_of_contents_number","conversion_output":true,"parent_id":"339e58ebbece47c89cff16866cfc0b6d","text":"44","text_display":" ..... 44","confidence":1,"confidence_rate":1},{"cnt":[[243,1564],[1760,1564],[1760,1622],[243,1622]],"region":{"top_left_x":242,"top_left_y":1564,"width":1518,"height":59},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb5dd71e48714313826626b442a364bb","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["f5839ef24d984c85b6c6b4057f74140e","845cea72f7254142aa2561be9d7130a4","3e96b2553cd94de6ae27d6aa46f9a01d"],"text":"","text_display":""},{"cnt":[[249,1568],[309,1568],[309,1611],[249,1611]],"region":{"top_left_x":249,"top_left_y":1568,"width":61,"height":44},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5839ef24d984c85b6c6b4057f74140e","type":"table_of_contents_item","conversion_output":true,"parent_id":"bb5dd71e48714313826626b442a364bb","text":"5.5","text_display":"\n5.5","confidence":1,"confidence_rate":1},{"cnt":[[571,1568],[1106,1568],[1106,1618],[571,1618]],"region":{"top_left_x":571,"top_left_y":1568,"width":536,"height":50},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"845cea72f7254142aa2561be9d7130a4","type":"table_of_contents_item","conversion_output":true,"parent_id":"bb5dd71e48714313826626b442a364bb","text":"Criteria for Subject Withdrawal","text_display":" Criteria for Subject Withdrawal","confidence":1,"confidence_rate":1},{"cnt":[[1704,1568],[1757,1568],[1757,1611],[1704,1611]],"region":{"top_left_x":1703,"top_left_y":1568,"width":55,"height":44},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e96b2553cd94de6ae27d6aa46f9a01d","type":"table_of_contents_number","conversion_output":true,"parent_id":"bb5dd71e48714313826626b442a364bb","text":"45","text_display":" ..... 45","confidence":1,"confidence_rate":1},{"cnt":[[243,1633],[1760,1633],[1760,1687],[243,1687]],"region":{"top_left_x":242,"top_left_y":1632,"width":1518,"height":55},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"662b0cf03b53461a8ae011db72582be7","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["6d23b71a61dd43a095245dcb9925b580","f67b138bad73459892a6e35d8377b1bb","567f833bf1a242729659a3979960e244"],"text":"","text_display":""},{"cnt":[[249,1637],[333,1637],[333,1678],[249,1678]],"region":{"top_left_x":249,"top_left_y":1637,"width":85,"height":41},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d23b71a61dd43a095245dcb9925b580","type":"table_of_contents_item","conversion_output":true,"parent_id":"662b0cf03b53461a8ae011db72582be7","text":"5.5.1","text_display":"\n5.5.1","confidence":1,"confidence_rate":1},{"cnt":[[571,1637],[1021,1637],[1021,1680],[571,1680]],"region":{"top_left_x":571,"top_left_y":1637,"width":450,"height":44},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f67b138bad73459892a6e35d8377b1bb","type":"table_of_contents_item","conversion_output":true,"parent_id":"662b0cf03b53461a8ae011db72582be7","text":"Withdrawal from the Trial","text_display":" Withdrawal from the Trial","confidence":1,"confidence_rate":1},{"cnt":[[1704,1637],[1757,1637],[1757,1680],[1704,1680]],"region":{"top_left_x":1703,"top_left_y":1637,"width":55,"height":44},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"567f833bf1a242729659a3979960e244","type":"table_of_contents_number","conversion_output":true,"parent_id":"662b0cf03b53461a8ae011db72582be7","text":"45","text_display":" ..... 45","confidence":1,"confidence_rate":1},{"cnt":[[243,1702],[1760,1702],[1760,1760],[243,1760]],"region":{"top_left_x":242,"top_left_y":1701,"width":1518,"height":59},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4173e18152e04c70afb9ad78a52973be","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["16026d9ebf0a467e96e09d75d23ada78","abb1538308434d3b90f9cc2b66853569","ca65da4347ef43ecaca9cbec12cc06cd"],"text":"","text_display":""},{"cnt":[[249,1708],[337,1708],[337,1749],[249,1749]],"region":{"top_left_x":249,"top_left_y":1708,"width":89,"height":41},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16026d9ebf0a467e96e09d75d23ada78","type":"table_of_contents_item","conversion_output":true,"parent_id":"4173e18152e04c70afb9ad78a52973be","text":"5.5.2","text_display":"\n5.5.2","confidence":1,"confidence_rate":1},{"cnt":[[571,1706],[1508,1706],[1508,1755],[571,1755]],"region":{"top_left_x":571,"top_left_y":1705,"width":938,"height":51},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abb1538308434d3b90f9cc2b66853569","type":"table_of_contents_item","conversion_output":true,"parent_id":"4173e18152e04c70afb9ad78a52973be","text":"Withdrawal from the Investigational Medicinal Product","text_display":" Withdrawal from the Investigational Medicinal Product","confidence":1,"confidence_rate":1},{"cnt":[[1704,1706],[1757,1706],[1757,1749],[1704,1749]],"region":{"top_left_x":1703,"top_left_y":1705,"width":55,"height":44},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca65da4347ef43ecaca9cbec12cc06cd","type":"table_of_contents_number","conversion_output":true,"parent_id":"4173e18152e04c70afb9ad78a52973be","text":"45","text_display":" ..... 45","confidence":1,"confidence_rate":1},{"cnt":[[243,1770],[1760,1770],[1760,1824],[243,1824]],"region":{"top_left_x":242,"top_left_y":1770,"width":1518,"height":55},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3dbd823a04654b16ae95cbcdb97e2363","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["f9936464223046dfa2e1e61722979f65","1f0aa50609b642f4aa89118a014c7375","ac8f35642bca4f339a991db04ff0b4c1"],"text":"","text_display":""},{"cnt":[[249,1775],[309,1775],[309,1818],[249,1818]],"region":{"top_left_x":249,"top_left_y":1774,"width":61,"height":44},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9936464223046dfa2e1e61722979f65","type":"table_of_contents_item","conversion_output":true,"parent_id":"3dbd823a04654b16ae95cbcdb97e2363","text":"5.6","text_display":"\n5.6","confidence":1,"confidence_rate":1},{"cnt":[[571,1775],[1227,1775],[1227,1820],[571,1820]],"region":{"top_left_x":571,"top_left_y":1774,"width":656,"height":46},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f0aa50609b642f4aa89118a014c7375","type":"table_of_contents_item","conversion_output":true,"parent_id":"3dbd823a04654b16ae95cbcdb97e2363","text":"Premature Discontinuation of the Trial","text_display":" Premature Discontinuation of the Trial","confidence":1,"confidence_rate":1},{"cnt":[[1704,1775],[1757,1775],[1757,1818],[1704,1818]],"region":{"top_left_x":1703,"top_left_y":1774,"width":55,"height":44},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac8f35642bca4f339a991db04ff0b4c1","type":"table_of_contents_number","conversion_output":true,"parent_id":"3dbd823a04654b16ae95cbcdb97e2363","text":"46","text_display":" ..... 46","confidence":1,"confidence_rate":1},{"cnt":[[243,1839],[1760,1839],[1760,1893],[243,1893]],"region":{"top_left_x":242,"top_left_y":1839,"width":1518,"height":54},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"632107bf5fd64c0eaa70b76dc8daa66a","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["4a07ca23fadd4cec8380fc96e38c90f3","9cb02527d64a47329de3e17d2c09b640","c76cf245d7934fa08c2d6770c3dd19f5"],"text":"","text_display":""},{"cnt":[[249,1843],[309,1843],[309,1886],[249,1886]],"region":{"top_left_x":249,"top_left_y":1843,"width":61,"height":44},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a07ca23fadd4cec8380fc96e38c90f3","type":"table_of_contents_item","conversion_output":true,"parent_id":"632107bf5fd64c0eaa70b76dc8daa66a","text":"5.7","text_display":"\n5.7","confidence":1,"confidence_rate":1},{"cnt":[[571,1843],[1008,1843],[1008,1888],[571,1888]],"region":{"top_left_x":571,"top_left_y":1843,"width":437,"height":46},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cb02527d64a47329de3e17d2c09b640","type":"table_of_contents_item","conversion_output":true,"parent_id":"632107bf5fd64c0eaa70b76dc8daa66a","text":"Definition of End of Trial","text_display":" Definition of End of Trial","confidence":1,"confidence_rate":1},{"cnt":[[1704,1843],[1757,1843],[1757,1886],[1704,1886]],"region":{"top_left_x":1703,"top_left_y":1843,"width":55,"height":44},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c76cf245d7934fa08c2d6770c3dd19f5","type":"table_of_contents_number","conversion_output":true,"parent_id":"632107bf5fd64c0eaa70b76dc8daa66a","text":"46","text_display":" ..... 46","confidence":1,"confidence_rate":1},{"cnt":[[243,1908],[1760,1908],[1760,2007],[243,2007]],"region":{"top_left_x":242,"top_left_y":1907,"width":1518,"height":100},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0668f94afe674062b78f97a5fdf03874","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["ae39adce05b144189802b5a7189c03f1","870aa19bfa6b4970887739560ead6c5f","bef80e4850064a459c4eedbf5cd68e1d","c0478b993efe4b2ab0a3198867b1e7f9"],"text":"","text_display":""},{"cnt":[[243,1912],[279,1912],[279,1955],[243,1955]],"region":{"top_left_x":242,"top_left_y":1912,"width":38,"height":44},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae39adce05b144189802b5a7189c03f1","type":"table_of_contents_item","conversion_output":true,"parent_id":"0668f94afe674062b78f97a5fdf03874","text":"6","text_display":"\n6","confidence":1,"confidence_rate":1},{"cnt":[[571,1912],[1652,1912],[1652,1962],[571,1962]],"region":{"top_left_x":571,"top_left_y":1912,"width":1082,"height":50},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"870aa19bfa6b4970887739560ead6c5f","type":"table_of_contents_item","conversion_output":true,"parent_id":"0668f94afe674062b78f97a5fdf03874","text":"Investigational Medicinal Products and Other Drugs Used in the","text_display":" Investigational Medicinal Products and Other Drugs Used in the","confidence":1,"confidence_rate":1},{"cnt":[[571,1959],[660,1959],[660,2002],[571,2002]],"region":{"top_left_x":571,"top_left_y":1959,"width":89,"height":44},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bef80e4850064a459c4eedbf5cd68e1d","type":"table_of_contents_item","conversion_output":true,"parent_id":"0668f94afe674062b78f97a5fdf03874","text":"Trial","text_display":" Trial","confidence":1,"confidence_rate":1},{"cnt":[[1706,1959],[1757,1959],[1757,2002],[1706,2002]],"region":{"top_left_x":1705,"top_left_y":1959,"width":53,"height":44},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0478b993efe4b2ab0a3198867b1e7f9","type":"table_of_contents_number","conversion_output":true,"parent_id":"0668f94afe674062b78f97a5fdf03874","text":"46","text_display":" ..... 46","confidence":1,"confidence_rate":1},{"cnt":[[243,2024],[1760,2024],[1760,2086],[243,2086]],"region":{"top_left_x":242,"top_left_y":2023,"width":1518,"height":64},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1075a4050fff46449f7d0452a641c7d8","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["e9ed4f344c954edba5f9df63910b5f91","6f7e01ff8fcc41ca8b76222eb2568cf6","3683427a6f964d889f072e115ac4f810"],"text":"","text_display":""},{"cnt":[[245,2030],[305,2030],[305,2075],[245,2075]],"region":{"top_left_x":244,"top_left_y":2030,"width":62,"height":46},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9ed4f344c954edba5f9df63910b5f91","type":"table_of_contents_item","conversion_output":true,"parent_id":"1075a4050fff46449f7d0452a641c7d8","text":"6.1","text_display":"\n6.1","confidence":1,"confidence_rate":1},{"cnt":[[571,2028],[1412,2028],[1412,2078],[571,2078]],"region":{"top_left_x":571,"top_left_y":2028,"width":841,"height":50},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f7e01ff8fcc41ca8b76222eb2568cf6","type":"table_of_contents_item","conversion_output":true,"parent_id":"1075a4050fff46449f7d0452a641c7d8","text":"Description of Investigational Medicinal Products","text_display":" Description of Investigational Medicinal Products","confidence":1,"confidence_rate":1},{"cnt":[[1704,2028],[1757,2028],[1757,2073],[1704,2073]],"region":{"top_left_x":1703,"top_left_y":2028,"width":55,"height":46},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3683427a6f964d889f072e115ac4f810","type":"table_of_contents_number","conversion_output":true,"parent_id":"1075a4050fff46449f7d0452a641c7d8","text":"46","text_display":" ..... 46","confidence":1,"confidence_rate":1},{"cnt":[[243,2093],[1760,2093],[1760,2151],[243,2151]],"region":{"top_left_x":242,"top_left_y":2092,"width":1518,"height":59},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7567344acf2402c990d8d45ce24a45f","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["1fbbd9272d0c433387c49ea81855ccb6","37748f9297e14fe78beb1504ebcdcfef","d3cb500f5b3843c3976dd66f67629d60"],"text":"","text_display":""},{"cnt":[[247,2099],[333,2099],[333,2140],[247,2140]],"region":{"top_left_x":247,"top_left_y":2099,"width":87,"height":41},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fbbd9272d0c433387c49ea81855ccb6","type":"table_of_contents_item","conversion_output":true,"parent_id":"a7567344acf2402c990d8d45ce24a45f","text":"6.1.1","text_display":"\n6.1.1","confidence":1,"confidence_rate":1},{"cnt":[[571,2097],[758,2097],[758,2146],[571,2146]],"region":{"top_left_x":571,"top_left_y":2096,"width":188,"height":51},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37748f9297e14fe78beb1504ebcdcfef","type":"table_of_contents_item","conversion_output":true,"parent_id":"a7567344acf2402c990d8d45ce24a45f","text":"Sprifermin","text_display":" Sprifermin","confidence":1,"confidence_rate":1},{"cnt":[[1702,2097],[1757,2097],[1757,2140],[1702,2140]],"region":{"top_left_x":1701,"top_left_y":2096,"width":57,"height":44},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3cb500f5b3843c3976dd66f67629d60","type":"table_of_contents_number","conversion_output":true,"parent_id":"a7567344acf2402c990d8d45ce24a45f","text":"47","text_display":" ..... 47","confidence":1,"confidence_rate":1},{"cnt":[[243,2161],[1760,2161],[1760,2215],[243,2215]],"region":{"top_left_x":242,"top_left_y":2161,"width":1518,"height":55},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ced45fd30a4841a4afe618ab4748b000","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["4e3689cbedac4a93a5e2594f0859151d","762b681bf6224caeba65bc7e292fb824","43db67346df64d9f853f0aa8b6094399"],"text":"","text_display":""},{"cnt":[[249,2166],[337,2166],[337,2209],[249,2209]],"region":{"top_left_x":249,"top_left_y":2165,"width":89,"height":44},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e3689cbedac4a93a5e2594f0859151d","type":"table_of_contents_item","conversion_output":true,"parent_id":"ced45fd30a4841a4afe618ab4748b000","text":"6.1.2","text_display":"\n6.1.2","confidence":1,"confidence_rate":1},{"cnt":[[571,2166],[711,2166],[711,2211],[571,2211]],"region":{"top_left_x":571,"top_left_y":2165,"width":141,"height":46},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"762b681bf6224caeba65bc7e292fb824","type":"table_of_contents_item","conversion_output":true,"parent_id":"ced45fd30a4841a4afe618ab4748b000","text":"Placebo","text_display":" Placebo","confidence":1,"confidence_rate":1},{"cnt":[[1704,2166],[1757,2166],[1757,2209],[1704,2209]],"region":{"top_left_x":1703,"top_left_y":2165,"width":55,"height":44},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43db67346df64d9f853f0aa8b6094399","type":"table_of_contents_number","conversion_output":true,"parent_id":"ced45fd30a4841a4afe618ab4748b000","text":"47","text_display":" ..... 47","confidence":1,"confidence_rate":1},{"cnt":[[243,2230],[1760,2230],[1760,2288],[243,2288]],"region":{"top_left_x":242,"top_left_y":2230,"width":1518,"height":59},"line":105,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"082edccc95924a0eae752573493460ef","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["73ca340bfca940208ea57f841527e464","118aa36b00874cfbb9115860adf6b0f5","ee31ecfd18b0491fb77aac5fabd57cde"],"text":"","text_display":""},{"cnt":[[249,2237],[309,2237],[309,2282],[249,2282]],"region":{"top_left_x":249,"top_left_y":2236,"width":61,"height":46},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73ca340bfca940208ea57f841527e464","type":"table_of_contents_item","conversion_output":true,"parent_id":"082edccc95924a0eae752573493460ef","text":"6.2","text_display":"\n6.2","confidence":1,"confidence_rate":1},{"cnt":[[571,2234],[1038,2234],[1038,2284],[571,2284]],"region":{"top_left_x":571,"top_left_y":2234,"width":467,"height":50},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"118aa36b00874cfbb9115860adf6b0f5","type":"table_of_contents_item","conversion_output":true,"parent_id":"082edccc95924a0eae752573493460ef","text":"Dosage and Administration","text_display":" Dosage and Administration","confidence":1,"confidence_rate":1},{"cnt":[[1704,2234],[1757,2234],[1757,2277],[1704,2277]],"region":{"top_left_x":1703,"top_left_y":2234,"width":55,"height":44},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee31ecfd18b0491fb77aac5fabd57cde","type":"table_of_contents_number","conversion_output":true,"parent_id":"082edccc95924a0eae752573493460ef","text":"47","text_display":" ..... 47","confidence":1,"confidence_rate":1},{"cnt":[[243,2299],[1757,2299],[1757,2357],[243,2357]],"region":{"top_left_x":242,"top_left_y":2298,"width":1516,"height":59},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce3851a7cc3a49fea78d5fb8da358edf","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["1e07b5b8826c4076af8679bdfd76321c","8afd5d4fec9741869072f2e1c8cde359","3c4e5ab3ecdd41038b0f424b0cdd25f9"],"text":"","text_display":""},{"cnt":[[249,2305],[305,2305],[305,2350],[249,2350]],"region":{"top_left_x":249,"top_left_y":2305,"width":57,"height":46},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e07b5b8826c4076af8679bdfd76321c","type":"table_of_contents_item","conversion_output":true,"parent_id":"ce3851a7cc3a49fea78d5fb8da358edf","text":"6.3","text_display":"\n6.3","confidence":1,"confidence_rate":1},{"cnt":[[571,2303],[1137,2303],[1137,2353],[571,2353]],"region":{"top_left_x":571,"top_left_y":2303,"width":566,"height":50},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8afd5d4fec9741869072f2e1c8cde359","type":"table_of_contents_item","conversion_output":true,"parent_id":"ce3851a7cc3a49fea78d5fb8da358edf","text":"Assignment to Treatment Groups","text_display":" Assignment to Treatment Groups","confidence":1,"confidence_rate":1},{"cnt":[[1706,2303],[1757,2303],[1757,2346],[1706,2346]],"region":{"top_left_x":1705,"top_left_y":2303,"width":53,"height":44},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c4e5ab3ecdd41038b0f424b0cdd25f9","type":"table_of_contents_number","conversion_output":true,"parent_id":"ce3851a7cc3a49fea78d5fb8da358edf","text":"48","text_display":" ..... 48","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1757,2368],[1757,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2367,"width":1514,"height":59},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71a908736bb04a72929f3689bccec9a2","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["826b2fd818564577888eec5ee176b2c1","deec2bc588ed46a9b0078f6f79e9f036","e6e6aed27bc44e9aae5b0405a4b692ee"],"text":"","text_display":""},{"cnt":[[249,2372],[309,2372],[309,2417],[249,2417]],"region":{"top_left_x":249,"top_left_y":2371,"width":61,"height":46},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"826b2fd818564577888eec5ee176b2c1","type":"table_of_contents_item","conversion_output":true,"parent_id":"71a908736bb04a72929f3689bccec9a2","text":"6.4","text_display":"\n6.4","confidence":1,"confidence_rate":1},{"cnt":[[571,2372],[1162,2372],[1162,2421],[571,2421]],"region":{"top_left_x":571,"top_left_y":2371,"width":592,"height":51},"line":115,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"deec2bc588ed46a9b0078f6f79e9f036","type":"table_of_contents_item","conversion_output":true,"parent_id":"71a908736bb04a72929f3689bccec9a2","text":"Other Drugs to be used in the Trial","text_display":" Other Drugs to be used in the Trial","confidence":1,"confidence_rate":1},{"cnt":[[1706,2372],[1757,2372],[1757,2415],[1706,2415]],"region":{"top_left_x":1705,"top_left_y":2371,"width":53,"height":44},"line":116,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6e6aed27bc44e9aae5b0405a4b692ee","type":"table_of_contents_number","conversion_output":true,"parent_id":"71a908736bb04a72929f3689bccec9a2","text":"48","text_display":" ..... 48","confidence":1,"confidence_rate":1},{"cnt":[[243,2436],[1760,2436],[1760,2490],[243,2490]],"region":{"top_left_x":242,"top_left_y":2436,"width":1518,"height":55},"line":117,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af6658df1aac4016aa8fcc95c7876ad5","type":"table_of_contents_row","conversion_output":false,"parent_id":"71236384864042418ee0850da1257684","children_ids":["555158fcd5604c49ac95e4da892018f0","8a1b00693bbe4ff4bf2e3d445325e2c1","3818d47cf9d04d50ae7390b4ecd6a8d0"],"text":"","text_display":""},{"cnt":[[247,2441],[307,2441],[307,2488],[247,2488]],"region":{"top_left_x":247,"top_left_y":2440,"width":61,"height":48},"line":118,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"555158fcd5604c49ac95e4da892018f0","type":"table_of_contents_item","conversion_output":true,"parent_id":"af6658df1aac4016aa8fcc95c7876ad5","text":"6.5","text_display":"\n6.5","confidence":1,"confidence_rate":1},{"cnt":[[571,2441],[1257,2441],[1257,2490],[571,2490]],"region":{"top_left_x":571,"top_left_y":2440,"width":686,"height":51},"line":119,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a1b00693bbe4ff4bf2e3d445325e2c1","type":"table_of_contents_item","conversion_output":true,"parent_id":"af6658df1aac4016aa8fcc95c7876ad5","text":"Concomitant Medications and Therapies","text_display":" Concomitant Medications and Therapies","confidence":1,"confidence_rate":1},{"cnt":[[1704,2441],[1757,2441],[1757,2488],[1704,2488]],"region":{"top_left_x":1703,"top_left_y":2440,"width":55,"height":48},"line":120,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3818d47cf9d04d50ae7390b4ecd6a8d0","type":"table_of_contents_number","conversion_output":true,"parent_id":"af6658df1aac4016aa8fcc95c7876ad5","text":"49","text_display":" ..... 49","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":121,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ce859178b04948ebaaf9888ed063264c","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[447,2509],[507,2509],[507,2548],[447,2548]],"region":{"top_left_x":446,"top_left_y":2509,"width":62,"height":40},"line":122,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8966a5e1609645d7acceca59952fe4ff","type":"page_info","conversion_output":false,"text":"CCI","text_display":"","confidence":0.8693501236848533,"confidence_rate":0.9826510895572224},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":123,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"243cbf19838a4c9691ec8f358551382d","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1523,2531],[1603,2531],[1603,2565],[1523,2565]],"region":{"top_left_x":1523,"top_left_y":2530,"width":80,"height":36},"line":124,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f9e3dff22f24e9a9607c5cfdff96a71","type":"page_info","conversion_output":false,"text":"7/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2608],[1796,2608]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":109},"line":125,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"5788f9b013854be096d88f41ae95844d","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999186032298787}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-008","page":8,"lines":[{"cnt":[[245,129],[434,129],[434,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":190,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce5d47f6998a424f93aca85edf14915a","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63bc3944d0714a36b4c479035ac108bd","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64d30957884a4f86acbf7100bc58c338","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,277],[1757,277],[1757,329],[245,329]],"region":{"top_left_x":244,"top_left_y":277,"width":1514,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"628e528274f9473cb64c4864fdeb0d25","type":"text","conversion_output":true,"text":"6.5.1 Permitted Medicines ................................................................... 49","text_display":"\n6.5.1 Permitted Medicines ................................................................... 49","confidence":0.49075543806488087,"confidence_rate":0.9929071799787914},{"cnt":[[245,348],[1755,348],[1755,402],[245,402]],"region":{"top_left_x":244,"top_left_y":348,"width":1512,"height":54},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da88bd8762a34c86b2657505c6512874","type":"text","conversion_output":true,"text":"6.5.2 Non-permitted Medicines ............................................................. 50","text_display":"\n6.5.2 Non-permitted Medicines ............................................................. 50","confidence":0.46491308559667355,"confidence_rate":0.9922151053447787},{"cnt":[[245,417],[1755,417],[1755,466],[245,466]],"region":{"top_left_x":244,"top_left_y":416,"width":1512,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2579f759f4448429b10baea9d2cdb91","type":"text","conversion_output":true,"text":"6.5.3 Other Trial Considerations ............................................................ 51","text_display":"\n6.5.3 Other Trial Considerations ............................................................ 51","confidence":0.5610353382732468,"confidence_rate":0.9942369565751361},{"cnt":[[245,486],[1755,486],[1755,539],[245,539]],"region":{"top_left_x":244,"top_left_y":485,"width":1512,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"586defe95b484ca58a2d4ba846c9be2f","type":"text","conversion_output":true,"text":"6.5.4 Special Precautions ...................................................................... 51","text_display":"\n6.5.4 Special Precautions ...................................................................... 51","confidence":0.3635799599591317,"confidence_rate":0.9902252127340095},{"cnt":[[245,554],[1755,554],[1755,608],[245,608]],"region":{"top_left_x":244,"top_left_y":554,"width":1512,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2f84b0df1464e0b8642e7fa6b8a4598","type":"text","conversion_output":true,"text":"6.6 Packaging and Labeling............................................................... 51","text_display":"\n6.6 Packaging and Labeling............................................................... 51","confidence":0.6783634481829707,"confidence_rate":0.9959233629226023},{"cnt":[[245,623],[1755,623],[1755,677],[245,677]],"region":{"top_left_x":244,"top_left_y":623,"width":1512,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"782e943cae954345a48a5873746fabe1","type":"text","conversion_output":true,"text":"6.7 Preparation, Handling and Storage ................................................ 51","text_display":"\n6.7 Preparation, Handling and Storage ................................................ 51","confidence":0.8321406637316752,"confidence_rate":0.9980046695687014},{"cnt":[[245,692],[1755,692],[1755,746],[245,746]],"region":{"top_left_x":244,"top_left_y":691,"width":1512,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"572e827734744614b7d71f69a77811fd","type":"text","conversion_output":true,"text":"6.8 Investigational Medicinal Product Accountability ............................ 52","text_display":"\n6.8 Investigational Medicinal Product Accountability ............................ 52","confidence":0.9630247029008387,"confidence_rate":0.999571952825988},{"cnt":[[245,761],[1755,761],[1755,814],[245,814]],"region":{"top_left_x":244,"top_left_y":760,"width":1512,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42417718339a404c927d3fc9c62f2532","type":"text","conversion_output":true,"text":"6.9 Assessment of Investigational Medicinal Product Compliance ......... 52","text_display":"\n6.9 Assessment of Investigational Medicinal Product Compliance ......... 52","confidence":0.9921875,"confidence_rate":0.9999007242008136},{"cnt":[[245,829],[1755,829],[1755,883],[245,883]],"region":{"top_left_x":244,"top_left_y":829,"width":1512,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5b5e02b776c4fed83a038bf433eb619","type":"text","conversion_output":true,"text":"6.10 Method of Blinding....................................................................... 53","text_display":"\n6.10 Method of Blinding....................................................................... 53","confidence":0.691668211614284,"confidence_rate":0.9963566639911704},{"cnt":[[245,898],[1755,898],[1755,952],[245,952]],"region":{"top_left_x":244,"top_left_y":898,"width":1512,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fccd7e0361742e58f100aa9d334c8d3","type":"text","conversion_output":true,"text":"6.11 Emergency Unblinding ................................................................. 53","text_display":"\n6.11 Emergency Unblinding ................................................................. 53","confidence":0.3804151638480052,"confidence_rate":0.990085638617943},{"cnt":[[245,967],[1755,967],[1755,1016],[245,1016]],"region":{"top_left_x":244,"top_left_y":966,"width":1512,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a76bd88c4adc4cc3bbd19ea1f7d5d249","type":"text","conversion_output":true,"text":"6.12 Treatment of Overdose ................................................................. 53","text_display":"\n6.12 Treatment of Overdose ................................................................. 53","confidence":0.2945143772927492,"confidence_rate":0.9876037251771578},{"cnt":[[245,1036],[1757,1036],[1757,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1035,"width":1514,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a290552f129435bb3d5a763409e89ec","type":"text","conversion_output":true,"text":"6.13 Medical Care of Subjects after End of Trial................................... 54","text_display":"\n6.13 Medical Care of Subjects after End of Trial................................... 54","confidence":0.4890875401675809,"confidence_rate":0.992084672642814},{"cnt":[[245,1104],[1757,1104],[1757,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1104,"width":1514,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f9fbc6fbe274d9d90babb6d736d7572","type":"text","conversion_output":true,"text":"7 Trial Procedures and Assessments................................................. 54","text_display":"\n\n7 Trial Procedures and Assessments................................................. 54","confidence":0.6271899546583304,"confidence_rate":0.9947720749192249},{"cnt":[[245,1173],[1757,1173],[1757,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1514,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b316031cf2f455586da9ed21758f303","type":"text","conversion_output":true,"text":"7.1 Schedule of Assessments ............................................................... 54","text_display":"\n7.1 Schedule of Assessments ............................................................... 54","confidence":0.3535950686056341,"confidence_rate":0.9894478756388043},{"cnt":[[245,1242],[1757,1242],[1757,1291],[245,1291]],"region":{"top_left_x":244,"top_left_y":1241,"width":1514,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"727700078dd64d13aa797ac8a54ab428","type":"text","conversion_output":true,"text":"7.1.1 General Instructions....................................................................... 54","text_display":"\n7.1.1 General Instructions....................................................................... 54","confidence":0.33779621575885965,"confidence_rate":0.9896185660666255},{"cnt":[[245,1308],[1755,1308],[1755,1364],[245,1364]],"region":{"top_left_x":244,"top_left_y":1308,"width":1512,"height":57},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a08f3d4bca294412b691a4d5695cc608","type":"text","conversion_output":true,"text":"7.1.2 Screening Period (Visits 1a and 1b) ............................................... 57","text_display":"\n7.1.2 Screening Period (Visits 1a and 1b) ............................................... 57","confidence":0.9161365032196045,"confidence_rate":0.9990880212678134},{"cnt":[[245,1379],[1635,1379],[1635,1424],[245,1424]],"region":{"top_left_x":244,"top_left_y":1379,"width":1391,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32fb171d8bb8453aad5796abf48fb22f","type":"text","conversion_output":true,"text":"7.1.3 Double-Blind Placebo-Controlled Treatment Phase (Visits 2 to","text_display":"\n7.1.3 Double-Blind Placebo-Controlled Treatment Phase (Visits 2 to","confidence":0.99951171875,"confidence_rate":0.9999934000150488},{"cnt":[[569,1429],[1755,1429],[1755,1480],[569,1480]],"region":{"top_left_x":569,"top_left_y":1428,"width":1187,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e54177391ab45e2977b19cd70e7d31d","type":"text","conversion_output":true,"text":"22) .................................................................................................. 59","text_display":" 22) .................................................................................................. 59","confidence":0.27761509171259013,"confidence_rate":0.9883117828324668},{"cnt":[[245,1495],[1755,1495],[1755,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1495,"width":1512,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"927b6ff92b6e439d92bf66661b5e3548","type":"text","conversion_output":true,"text":"7.1.4 Extended Follow-Up Phase ............................................................ 65","text_display":"\n7.1.4 Extended Follow-Up Phase ............................................................ 65","confidence":0.5165742192559875,"confidence_rate":0.9932824976035236},{"cnt":[[245,1564],[1757,1564],[1757,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1564,"width":1514,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c78316c8df544909853d2ad63229960c","type":"text","conversion_output":true,"text":"7.1.5 Follow-Up in Case of Early Termination ........................................ 66","text_display":"\n7.1.5 Follow-Up in Case of Early Termination ........................................ 66","confidence":0.9232224903535098,"confidence_rate":0.9991320614178257},{"cnt":[[245,1633],[1757,1633],[1757,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1632,"width":1514,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8df13cff49b94a6bbf98e7a8607e2bf0","type":"text","conversion_output":true,"text":"7.2 Demographic and Other Baseline Characteristics ............................ 67","text_display":"\n7.2 Demographic and Other Baseline Characteristics ............................ 67","confidence":0.986372709274292,"confidence_rate":0.9998404662790483},{"cnt":[[245,1702],[1757,1702],[1757,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1701,"width":1514,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6ff5454192e4d7bb5b0720b23eafc59","type":"text","conversion_output":true,"text":"7.3 Assessment of Efficacy................................................................... 67","text_display":"\n7.3 Assessment of Efficacy................................................................... 67","confidence":0.6540194446392111,"confidence_rate":0.9957628203233098},{"cnt":[[245,1770],[1755,1770],[1755,1824],[245,1824]],"region":{"top_left_x":244,"top_left_y":1770,"width":1512,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6230fca4012b43d0b781fc3e3b3e9a4b","type":"text","conversion_output":true,"text":"7.3.1 Magnetic Resonance Imaging........................................................ 68","text_display":"\n7.3.1 Magnetic Resonance Imaging........................................................ 68","confidence":0.9157582829540345,"confidence_rate":0.9990740833217472},{"cnt":[[245,1839],[1755,1839],[1755,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1839,"width":1512,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80d77bf83b69463aa3ff2eaf5e05b8e3","type":"text","conversion_output":true,"text":"7.3.2 WOMAC Questionnaire ................................................................ 69","text_display":"\n7.3.2 WOMAC Questionnaire ................................................................ 69","confidence":0.5000972571480133,"confidence_rate":0.9928816144694879},{"cnt":[[245,1908],[1757,1908],[1757,1957],[245,1957]],"region":{"top_left_x":244,"top_left_y":1907,"width":1514,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"788c638e909842b08450d574a4f8fbfc","type":"text","conversion_output":true,"text":"7.3.3 Patient's Global Assessment......................................................... 70","text_display":"\n7.3.3 Patient's Global Assessment......................................................... 70","confidence":0.6020614309151018,"confidence_rate":0.9947827727766736},{"cnt":[[245,1977],[1755,1977],[1755,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1976,"width":1512,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b44a5e67e0264194a4282baf213d6593","type":"text","conversion_output":true,"text":"7.3.4 X-Ray Imaging ............................................................................. 70","text_display":"\n7.3.4 X-Ray Imaging ............................................................................. 70","confidence":0.46047804795834263,"confidence_rate":0.9925710962119364},{"cnt":[[245,2045],[1755,2045],[1755,2095],[245,2095]],"region":{"top_left_x":244,"top_left_y":2045,"width":1512,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c4d78f996134d2f93e08e155519112d","type":"text","conversion_output":true,"text":"7.3.5 20-Meter Walk Test..................................................................... 71","text_display":"\n7.3.5 20-Meter Walk Test..................................................................... 71","confidence":0.4278088456850293,"confidence_rate":0.9915451568813671},{"cnt":[[245,2114],[1755,2114],[1755,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2114,"width":1512,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9141249127746238f13dbc1032119e0","type":"text","conversion_output":true,"text":"7.4 Assessment of Safety................................................................... 71","text_display":"\n7.4 Assessment of Safety................................................................... 71","confidence":0.6491468690918626,"confidence_rate":0.9956005602244425},{"cnt":[[245,2183],[1755,2183],[1755,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2182,"width":1512,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d37721daf6f475c88f44c422127553f","type":"text","conversion_output":true,"text":"7.4.1 Adverse Events ............................................................................. 71","text_display":"\n7.4.1 Adverse Events ............................................................................. 71","confidence":0.5364759554210357,"confidence_rate":0.9940867568757209},{"cnt":[[245,2252],[1757,2252],[1757,2305],[245,2305]],"region":{"top_left_x":244,"top_left_y":2251,"width":1514,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fea2b0fc189d46479f9b9f95674a7c43","type":"text","conversion_output":true,"text":"7.4.2 Pregnancy and In Utero Drug Exposure .......................................... 76","text_display":"\n7.4.2 Pregnancy and In Utero Drug Exposure .......................................... 76","confidence":0.8795112784960679,"confidence_rate":0.9986054418758681},{"cnt":[[245,2320],[1757,2320],[1757,2374],[245,2374]],"region":{"top_left_x":244,"top_left_y":2320,"width":1514,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"824678ecfaff4071a2f06426cfb24ce9","type":"text","conversion_output":true,"text":"7.4.3 Laboratory Assessments ................................................................ 77","text_display":"\n7.4.3 Laboratory Assessments ................................................................ 77","confidence":0.762459725601876,"confidence_rate":0.9972916183934529},{"cnt":[[245,2389],[1755,2389],[1755,2443],[245,2443]],"region":{"top_left_x":244,"top_left_y":2389,"width":1512,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f447aba2f706474e9b9f95f2624adb35","type":"text","conversion_output":true,"text":"7.4.4 Vital Signs, Physical Examinations, and Other Assessments............ 78","text_display":"\n7.4.4 Vital Signs, Physical Examinations, and Other Assessments............ 78","confidence":0.9844071865081787,"confidence_rate":0.999808363973096},{"cnt":[[245,2509],[507,2509],[507,2563],[245,2563]],"region":{"top_left_x":244,"top_left_y":2509,"width":264,"height":55},"line":36,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"542933e23b33419bab2226af436ae462","type":"page_info","conversion_output":false,"text":"Document No. CCl","text_display":"","confidence":0.5959692634642124,"confidence_rate":0.9756552242781811},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":37,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a713eddb409f4463b5f77c3ab0b188e8","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1523,2531],[1603,2531],[1603,2565],[1523,2565]],"region":{"top_left_x":1523,"top_left_y":2530,"width":80,"height":36},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f56b87cf895c4af48120266d4a3e8318","type":"page_info","conversion_output":false,"text":"8/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-009","page":9,"lines":[{"cnt":[[245,129],[434,129],[434,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":190,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47df2253498f4348b6a9f5b0d26de035","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86dc98af96424aeba53c4de11185cbe0","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4339de79ad64c5697fca4c1611abd6f","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[223,275],[1764,275],[1764,2499],[223,2499]],"region":{"top_left_x":223,"top_left_y":275,"width":1541,"height":2224},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","type":"table_of_contents_container","conversion_output":false,"children_ids":["5ebc3dd61f904438a2e574bc90209c2f","2da9654e53b5446fbc61974b7b76ed8c","c73211f4754c445daecc525f9329650f","b0ae697b32d84d5baa4b75fa3dbe6673","d20fa3d7d2d2442f933a0abcca7498ee","584e3b2a8ff7403ab5aef017fec0d105","9bccdd8f8a49463685ff9682fef4167a","1e2cf13dc72e4a1c9b50cf1376abb8fa","64b1aae0453b45f6b3af274d1f483fef","d266a096c467430dbf588064bb6689cb","af90ad8b2bc747f48582af7612c2ec64","2b17efac1a2e497091e62d090a5c6299","022ecc9a2bd64b7390381aac8bcb1136","67f80a0ba9154efc94563f04ce789d49","5da7590463634d7eb7867effb79ea81a","0e2991cf9e8e4c4b943f291fb8237b0e","e2b8ec607a1a4966ad6a45ac7f325519","533cfd393dcc4dc9889c3d877fc2ac25","cd0c6dcb09a347d7a95f8d0991a429be","f610631152364c628d53c02c369b7a5f","2642071a33c84425aec0fe9d3b5a8d44","9034283502e940148eea5c26290bf561","7a050cd382aa420cbf59d524ccdf6c49","f983bf10cf334e349003fba0dc79acdd","db0f6b1438644dd98bf75ca9d2ce351b","e49c834373864c8aa5eafc78867ea24d","4f3db0faa7804d998d6b3593e2710fae","16075f9e52b344d8b67d77dddfecb305","3061351519c644cfb97ea0dcad8bf8d5","c54d63f24ee54fa1b21bcae14f2ae944","9e67f18f433c4e1a9fa59b1109a5915d"],"text":"","text_display":""},{"cnt":[[243,277],[1760,277],[1760,329],[243,329]],"region":{"top_left_x":242,"top_left_y":277,"width":1518,"height":52},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ebc3dd61f904438a2e574bc90209c2f","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["1a281213e8a84a22bb22039121fb608d","f96a5ccf91da4dab8fd6692b833c9ff3","d6ed53b29995436b8c9a116ad82d441e"],"text":"","text_display":""},{"cnt":[[249,284],[307,284],[307,327],[249,327]],"region":{"top_left_x":249,"top_left_y":283,"width":59,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a281213e8a84a22bb22039121fb608d","type":"table_of_contents_item","conversion_output":true,"parent_id":"5ebc3dd61f904438a2e574bc90209c2f","text":"7.5","text_display":"\n7.5","confidence":1,"confidence_rate":1},{"cnt":[[571,284],[874,284],[874,324],[571,324]],"region":{"top_left_x":571,"top_left_y":283,"width":304,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f96a5ccf91da4dab8fd6692b833c9ff3","type":"table_of_contents_item","conversion_output":true,"parent_id":"5ebc3dd61f904438a2e574bc90209c2f","text":"Pharmacokinetics","text_display":" Pharmacokinetics","confidence":1,"confidence_rate":1},{"cnt":[[1706,277],[1753,277],[1753,322],[1706,322]],"region":{"top_left_x":1705,"top_left_y":277,"width":49,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6ed53b29995436b8c9a116ad82d441e","type":"table_of_contents_number","conversion_output":true,"parent_id":"5ebc3dd61f904438a2e574bc90209c2f","text":"78","text_display":" ..... 78","confidence":1,"confidence_rate":1},{"cnt":[[245,348],[1755,348],[1755,402],[245,402]],"region":{"top_left_x":244,"top_left_y":348,"width":1512,"height":54},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2da9654e53b5446fbc61974b7b76ed8c","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["c48d3f6c0b994c6497ea777cff7ce406","f17e9f57b0cd4b9681b069094d670555","4196532c7c0f40b3a55e36e980145caa"],"text":"","text_display":""},{"cnt":[[249,352],[333,352],[333,393],[249,393]],"region":{"top_left_x":249,"top_left_y":352,"width":85,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c48d3f6c0b994c6497ea777cff7ce406","type":"table_of_contents_item","conversion_output":true,"parent_id":"2da9654e53b5446fbc61974b7b76ed8c","text":"7.5.1","text_display":"\n7.5.1","confidence":1,"confidence_rate":1},{"cnt":[[571,352],[782,352],[782,397],[571,397]],"region":{"top_left_x":571,"top_left_y":352,"width":212,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f17e9f57b0cd4b9681b069094d670555","type":"table_of_contents_item","conversion_output":true,"parent_id":"2da9654e53b5446fbc61974b7b76ed8c","text":"Body Fluids","text_display":" Body Fluids","confidence":1,"confidence_rate":1},{"cnt":[[1706,346],[1753,346],[1753,391],[1706,391]],"region":{"top_left_x":1705,"top_left_y":345,"width":49,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4196532c7c0f40b3a55e36e980145caa","type":"table_of_contents_number","conversion_output":true,"parent_id":"2da9654e53b5446fbc61974b7b76ed8c","text":"79","text_display":" ..... 79","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1755,417],[1755,466],[245,466]],"region":{"top_left_x":244,"top_left_y":416,"width":1512,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c73211f4754c445daecc525f9329650f","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["dcf65c3429864e4ba780d743717abba9","a797d27a86d74fd09dd9d2850dda340e","924fe880bf654114af7b4d0edf4e7ebe"],"text":"","text_display":""},{"cnt":[[249,421],[337,421],[337,462],[249,462]],"region":{"top_left_x":249,"top_left_y":421,"width":89,"height":41},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcf65c3429864e4ba780d743717abba9","type":"table_of_contents_item","conversion_output":true,"parent_id":"c73211f4754c445daecc525f9329650f","text":"7.5.2","text_display":"\n7.5.2","confidence":1,"confidence_rate":1},{"cnt":[[571,421],[1076,421],[1076,462],[571,462]],"region":{"top_left_x":571,"top_left_y":421,"width":506,"height":41},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a797d27a86d74fd09dd9d2850dda340e","type":"table_of_contents_item","conversion_output":true,"parent_id":"c73211f4754c445daecc525f9329650f","text":"Pharmacokinetic Calculations","text_display":" Pharmacokinetic Calculations","confidence":0.99951171875,"confidence_rate":0.9999852000944255},{"cnt":[[1706,415],[1753,415],[1753,460],[1706,460]],"region":{"top_left_x":1705,"top_left_y":414,"width":49,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"924fe880bf654114af7b4d0edf4e7ebe","type":"table_of_contents_number","conversion_output":true,"parent_id":"c73211f4754c445daecc525f9329650f","text":"79","text_display":" ..... 79","confidence":1,"confidence_rate":1},{"cnt":[[245,486],[1755,486],[1755,539],[245,539]],"region":{"top_left_x":244,"top_left_y":485,"width":1512,"height":55},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0ae697b32d84d5baa4b75fa3dbe6673","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["a1aabdc3d9f5438580b991a9f0a354b5","4106fdc19ec242489cbddf238c3c7f47","c3d497d5d8de47a99bc5bcfe39f149c4"],"text":"","text_display":""},{"cnt":[[249,490],[307,490],[307,529],[249,529]],"region":{"top_left_x":249,"top_left_y":489,"width":59,"height":40},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1aabdc3d9f5438580b991a9f0a354b5","type":"table_of_contents_item","conversion_output":true,"parent_id":"b0ae697b32d84d5baa4b75fa3dbe6673","text":"7.6","text_display":"\n7.6","confidence":1,"confidence_rate":1},{"cnt":[[571,490],[1156,490],[1156,535],[571,535]],"region":{"top_left_x":571,"top_left_y":489,"width":585,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4106fdc19ec242489cbddf238c3c7f47","type":"table_of_contents_item","conversion_output":true,"parent_id":"b0ae697b32d84d5baa4b75fa3dbe6673","text":"Biomarkers and Pharmacogenetics","text_display":" Biomarkers and Pharmacogenetics","confidence":1,"confidence_rate":1},{"cnt":[[1706,483],[1753,483],[1753,529],[1706,529]],"region":{"top_left_x":1705,"top_left_y":483,"width":49,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3d497d5d8de47a99bc5bcfe39f149c4","type":"table_of_contents_number","conversion_output":true,"parent_id":"b0ae697b32d84d5baa4b75fa3dbe6673","text":"79","text_display":" ..... 79","confidence":1,"confidence_rate":1},{"cnt":[[245,554],[1755,554],[1755,608],[245,608]],"region":{"top_left_x":244,"top_left_y":554,"width":1512,"height":55},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d20fa3d7d2d2442f933a0abcca7498ee","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["6f3ff94a63e74447862fef5d1a6739d4","1976d96876a043b3ba0e9028ed9d1386","f0b84bb21d04400196a876f0c150d6a6"],"text":"","text_display":""},{"cnt":[[249,559],[333,559],[333,595],[249,595]],"region":{"top_left_x":249,"top_left_y":558,"width":85,"height":38},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f3ff94a63e74447862fef5d1a6739d4","type":"table_of_contents_item","conversion_output":true,"parent_id":"d20fa3d7d2d2442f933a0abcca7498ee","text":"7.6.1","text_display":"\n7.6.1","confidence":1,"confidence_rate":1},{"cnt":[[571,559],[1036,559],[1036,604],[571,604]],"region":{"top_left_x":571,"top_left_y":558,"width":465,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1976d96876a043b3ba0e9028ed9d1386","type":"table_of_contents_item","conversion_output":true,"parent_id":"d20fa3d7d2d2442f933a0abcca7498ee","text":"Biomarkers to be Analyzed","text_display":" Biomarkers to be Analyzed","confidence":1,"confidence_rate":1},{"cnt":[[1706,552],[1753,552],[1753,597],[1706,597]],"region":{"top_left_x":1705,"top_left_y":552,"width":49,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0b84bb21d04400196a876f0c150d6a6","type":"table_of_contents_number","conversion_output":true,"parent_id":"d20fa3d7d2d2442f933a0abcca7498ee","text":"79","text_display":" ..... 79","confidence":1,"confidence_rate":1},{"cnt":[[245,623],[1755,623],[1755,677],[245,677]],"region":{"top_left_x":244,"top_left_y":623,"width":1512,"height":54},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"584e3b2a8ff7403ab5aef017fec0d105","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["e637d23f5f4542c0bb66f26d9515785a","5798de4f52b34ae881868303659ca158","1adddc4559a14bf8847adecc5b1f9758"],"text":"","text_display":""},{"cnt":[[249,627],[333,627],[333,668],[249,668]],"region":{"top_left_x":249,"top_left_y":627,"width":85,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e637d23f5f4542c0bb66f26d9515785a","type":"table_of_contents_item","conversion_output":true,"parent_id":"584e3b2a8ff7403ab5aef017fec0d105","text":"7.6.2","text_display":"\n7.6.2","confidence":1,"confidence_rate":1},{"cnt":[[571,627],[1240,627],[1240,672],[571,672]],"region":{"top_left_x":571,"top_left_y":627,"width":669,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5798de4f52b34ae881868303659ca158","type":"table_of_contents_item","conversion_output":true,"parent_id":"584e3b2a8ff7403ab5aef017fec0d105","text":"Body Fluids for Biomarker Assessment","text_display":" Body Fluids for Biomarker Assessment","confidence":1,"confidence_rate":1},{"cnt":[[1706,623],[1753,623],[1753,666],[1706,666]],"region":{"top_left_x":1705,"top_left_y":623,"width":49,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1adddc4559a14bf8847adecc5b1f9758","type":"table_of_contents_number","conversion_output":true,"parent_id":"584e3b2a8ff7403ab5aef017fec0d105","text":"80","text_display":" ..... 80","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1755,692],[1755,746],[245,746]],"region":{"top_left_x":244,"top_left_y":691,"width":1512,"height":55},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bccdd8f8a49463685ff9682fef4167a","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["3ab616b563d442dc857771c285968dbc","9a74f89f7e9f4d3399c71fb80e269ba6","5af17c1ceabd4af887b38545bbbccedb"],"text":"","text_display":""},{"cnt":[[249,696],[333,696],[333,737],[249,737]],"region":{"top_left_x":249,"top_left_y":696,"width":85,"height":41},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ab616b563d442dc857771c285968dbc","type":"table_of_contents_item","conversion_output":true,"parent_id":"9bccdd8f8a49463685ff9682fef4167a","text":"7.6.3","text_display":"\n7.6.3","confidence":1,"confidence_rate":1},{"cnt":[[571,696],[879,696],[879,741],[571,741]],"region":{"top_left_x":571,"top_left_y":696,"width":308,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a74f89f7e9f4d3399c71fb80e269ba6","type":"table_of_contents_item","conversion_output":true,"parent_id":"9bccdd8f8a49463685ff9682fef4167a","text":"Pharmacogenetics","text_display":" Pharmacogenetics","confidence":1,"confidence_rate":1},{"cnt":[[1706,692],[1753,692],[1753,735],[1706,735]],"region":{"top_left_x":1705,"top_left_y":691,"width":49,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5af17c1ceabd4af887b38545bbbccedb","type":"table_of_contents_number","conversion_output":true,"parent_id":"9bccdd8f8a49463685ff9682fef4167a","text":"80","text_display":" ..... 80","confidence":1,"confidence_rate":1},{"cnt":[[245,761],[1755,761],[1755,810],[245,810]],"region":{"top_left_x":244,"top_left_y":760,"width":1512,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e2cf13dc72e4a1c9b50cf1376abb8fa","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["820312d036b941e489d61454fbd17603","cf3c03bdb2044ef4b5a0a79a93fa14a4","cad99fe3ea60475e965358fb341030fd"],"text":"","text_display":""},{"cnt":[[249,765],[305,765],[305,804],[249,804]],"region":{"top_left_x":249,"top_left_y":764,"width":57,"height":40},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"820312d036b941e489d61454fbd17603","type":"table_of_contents_item","conversion_output":true,"parent_id":"1e2cf13dc72e4a1c9b50cf1376abb8fa","text":"7.7","text_display":"\n7.7","confidence":1,"confidence_rate":1},{"cnt":[[571,765],[896,765],[896,801],[571,801]],"region":{"top_left_x":571,"top_left_y":764,"width":325,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf3c03bdb2044ef4b5a0a79a93fa14a4","type":"table_of_contents_item","conversion_output":true,"parent_id":"1e2cf13dc72e4a1c9b50cf1376abb8fa","text":"Other Assessments","text_display":" Other Assessments","confidence":1,"confidence_rate":1},{"cnt":[[1706,761],[1751,761],[1751,804],[1706,804]],"region":{"top_left_x":1705,"top_left_y":760,"width":46,"height":44},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cad99fe3ea60475e965358fb341030fd","type":"table_of_contents_number","conversion_output":true,"parent_id":"1e2cf13dc72e4a1c9b50cf1376abb8fa","text":"81","text_display":" ..... 81","confidence":1,"confidence_rate":1},{"cnt":[[243,829],[1755,829],[1755,930],[243,930]],"region":{"top_left_x":242,"top_left_y":829,"width":1514,"height":102},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64b1aae0453b45f6b3af274d1f483fef","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["b3def76c5ab54809976a8e622bb5369d","15769c01f6cf4b5b859fc2e93657268e","26970650227347fabfc3ffa19409b08a","8595bfe27c3547488e073dba0d04d42b"],"text":"","text_display":""},{"cnt":[[249,834],[333,834],[333,870],[249,870]],"region":{"top_left_x":249,"top_left_y":833,"width":85,"height":38},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3def76c5ab54809976a8e622bb5369d","type":"table_of_contents_item","conversion_output":true,"parent_id":"64b1aae0453b45f6b3af274d1f483fef","text":"7.7.1","text_display":"\n7.7.1","confidence":1,"confidence_rate":1},{"cnt":[[571,834],[1639,834],[1639,879],[571,879]],"region":{"top_left_x":571,"top_left_y":833,"width":1069,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15769c01f6cf4b5b859fc2e93657268e","type":"table_of_contents_item","conversion_output":true,"parent_id":"64b1aae0453b45f6b3af274d1f483fef","text":"Knee Injury and Osteoarthritis Outcome Score - Quality of Life","text_display":" Knee Injury and Osteoarthritis Outcome Score - Quality of Life","confidence":1,"confidence_rate":1},{"cnt":[[571,881],[1089,881],[1089,926],[571,926]],"region":{"top_left_x":571,"top_left_y":880,"width":519,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26970650227347fabfc3ffa19409b08a","type":"table_of_contents_item","conversion_output":true,"parent_id":"64b1aae0453b45f6b3af274d1f483fef","text":"and Symptom Index Subscales","text_display":" and Symptom Index Subscales","confidence":1,"confidence_rate":1},{"cnt":[[1706,881],[1749,881],[1749,920],[1706,920]],"region":{"top_left_x":1705,"top_left_y":880,"width":44,"height":40},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8595bfe27c3547488e073dba0d04d42b","type":"table_of_contents_number","conversion_output":true,"parent_id":"64b1aae0453b45f6b3af274d1f483fef","text":"81","text_display":" ..... 81","confidence":1,"confidence_rate":1},{"cnt":[[245,945],[1755,945],[1755,999],[245,999]],"region":{"top_left_x":244,"top_left_y":945,"width":1512,"height":55},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d266a096c467430dbf588064bb6689cb","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["1453080fafc14d10a848e31ab04530be","c9944a1a85cc4a1dbc494270bd23a887","544a78ef36ac4d8982b93f79d1fcff54"],"text":"","text_display":""},{"cnt":[[249,950],[333,950],[333,986],[249,986]],"region":{"top_left_x":249,"top_left_y":949,"width":85,"height":38},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1453080fafc14d10a848e31ab04530be","type":"table_of_contents_item","conversion_output":true,"parent_id":"d266a096c467430dbf588064bb6689cb","text":"7.7.2","text_display":"\n7.7.2","confidence":1,"confidence_rate":1},{"cnt":[[571,950],[1652,950],[1652,999],[571,999]],"region":{"top_left_x":571,"top_left_y":949,"width":1082,"height":51},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9944a1a85cc4a1dbc494270bd23a887","type":"table_of_contents_item","conversion_output":true,"parent_id":"d266a096c467430dbf588064bb6689cb","text":"Medical Outcomes Study Short Form-36 General Health Survey","text_display":" Medical Outcomes Study Short Form-36 General Health Survey","confidence":1,"confidence_rate":1},{"cnt":[[1706,950],[1749,950],[1749,988],[1706,988]],"region":{"top_left_x":1705,"top_left_y":949,"width":44,"height":40},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"544a78ef36ac4d8982b93f79d1fcff54","type":"table_of_contents_number","conversion_output":true,"parent_id":"d266a096c467430dbf588064bb6689cb","text":"81","text_display":" ..... 81","confidence":1,"confidence_rate":1},{"cnt":[[243,1014],[1755,1014],[1755,1115],[243,1115]],"region":{"top_left_x":242,"top_left_y":1014,"width":1514,"height":102},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af90ad8b2bc747f48582af7612c2ec64","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["52aa0f86f7824084bb9b742e9b673f3e","7003a72a4c2347178f20dcb58fa3a2e8","9275559dd3b7482f99d2adb301f07bf5","da69d67e18e8406e99fa4e2567142c98"],"text":"","text_display":""},{"cnt":[[249,1018],[333,1018],[333,1059],[249,1059]],"region":{"top_left_x":249,"top_left_y":1018,"width":85,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52aa0f86f7824084bb9b742e9b673f3e","type":"table_of_contents_item","conversion_output":true,"parent_id":"af90ad8b2bc747f48582af7612c2ec64","text":"7.7.3","text_display":"\n7.7.3","confidence":1,"confidence_rate":1},{"cnt":[[571,1018],[1525,1018],[1525,1059],[571,1059]],"region":{"top_left_x":571,"top_left_y":1018,"width":955,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7003a72a4c2347178f20dcb58fa3a2e8","type":"table_of_contents_item","conversion_output":true,"parent_id":"af90ad8b2bc747f48582af7612c2ec64","text":"Measure of Intermittent and Constant Osteoarthritis Pain","text_display":" Measure of Intermittent and Constant Osteoarthritis Pain","confidence":1,"confidence_rate":1},{"cnt":[[571,1066],[810,1066],[810,1111],[571,1111]],"region":{"top_left_x":571,"top_left_y":1065,"width":239,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9275559dd3b7482f99d2adb301f07bf5","type":"table_of_contents_item","conversion_output":true,"parent_id":"af90ad8b2bc747f48582af7612c2ec64","text":"Questionnaire","text_display":" Questionnaire","confidence":1,"confidence_rate":1},{"cnt":[[1706,1068],[1753,1068],[1753,1106],[1706,1106]],"region":{"top_left_x":1705,"top_left_y":1067,"width":49,"height":40},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da69d67e18e8406e99fa4e2567142c98","type":"table_of_contents_number","conversion_output":true,"parent_id":"af90ad8b2bc747f48582af7612c2ec64","text":"82","text_display":" ..... 82","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1755,1130],[1755,1184],[245,1184]],"region":{"top_left_x":244,"top_left_y":1130,"width":1512,"height":54},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b17efac1a2e497091e62d090a5c6299","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["5922d7ee9b5c42c78e150c6fcb3f173b","6976a8788cd345419cd0b9e993893ed0","52c2ee6929b74aab98cdb3ee88d1607b"],"text":"","text_display":""},{"cnt":[[249,1134],[335,1134],[335,1175],[249,1175]],"region":{"top_left_x":249,"top_left_y":1134,"width":87,"height":42},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5922d7ee9b5c42c78e150c6fcb3f173b","type":"table_of_contents_item","conversion_output":true,"parent_id":"2b17efac1a2e497091e62d090a5c6299","text":"7.7.4","text_display":"\n7.7.4","confidence":1,"confidence_rate":1},{"cnt":[[571,1134],[1192,1134],[1192,1179],[571,1179]],"region":{"top_left_x":571,"top_left_y":1134,"width":622,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6976a8788cd345419cd0b9e993893ed0","type":"table_of_contents_item","conversion_output":true,"parent_id":"2b17efac1a2e497091e62d090a5c6299","text":"Patient Global Impression of Change","text_display":" Patient Global Impression of Change","confidence":1,"confidence_rate":1},{"cnt":[[1706,1134],[1753,1134],[1753,1175],[1706,1175]],"region":{"top_left_x":1705,"top_left_y":1134,"width":49,"height":42},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52c2ee6929b74aab98cdb3ee88d1607b","type":"table_of_contents_number","conversion_output":true,"parent_id":"2b17efac1a2e497091e62d090a5c6299","text":"82","text_display":" ..... 82","confidence":1,"confidence_rate":1},{"cnt":[[245,1199],[1755,1199],[1755,1253],[245,1253]],"region":{"top_left_x":244,"top_left_y":1198,"width":1512,"height":55},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"022ecc9a2bd64b7390381aac8bcb1136","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["1f648f77342b4ed88eb6492513b1c01b","376fbfb67de1400ba010eeb097e4470a","c4f553c647454bb7aadfe6c34e2bc2fd"],"text":"","text_display":""},{"cnt":[[249,1203],[333,1203],[333,1244],[249,1244]],"region":{"top_left_x":249,"top_left_y":1203,"width":85,"height":41},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f648f77342b4ed88eb6492513b1c01b","type":"table_of_contents_item","conversion_output":true,"parent_id":"022ecc9a2bd64b7390381aac8bcb1136","text":"7.7.5","text_display":"\n7.7.5","confidence":1,"confidence_rate":1},{"cnt":[[576,1203],[1319,1203],[1319,1248],[576,1248]],"region":{"top_left_x":575,"top_left_y":1203,"width":745,"height":46},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"376fbfb67de1400ba010eeb097e4470a","type":"table_of_contents_item","conversion_output":true,"parent_id":"022ecc9a2bd64b7390381aac8bcb1136","text":"11-Point Numerical Rating Scale Pain Score","text_display":" 11-Point Numerical Rating Scale Pain Score","confidence":0.99951171875,"confidence_rate":0.9999896085540316},{"cnt":[[1706,1205],[1753,1205],[1753,1244],[1706,1244]],"region":{"top_left_x":1705,"top_left_y":1205,"width":49,"height":39},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4f553c647454bb7aadfe6c34e2bc2fd","type":"table_of_contents_number","conversion_output":true,"parent_id":"022ecc9a2bd64b7390381aac8bcb1136","text":"83","text_display":" ..... 83","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1755,1268],[1755,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1267,"width":1512,"height":50},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67f80a0ba9154efc94563f04ce789d49","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["7cc6b95fca6c44b8b64286b1fa925d05","e75d03dd356f4652a75cb456d1b3a29e","27ce0702a30c4193a881b3cb83d7e6f7"],"text":"","text_display":""},{"cnt":[[249,1272],[335,1272],[335,1313],[249,1313]],"region":{"top_left_x":249,"top_left_y":1271,"width":87,"height":42},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7cc6b95fca6c44b8b64286b1fa925d05","type":"table_of_contents_item","conversion_output":true,"parent_id":"67f80a0ba9154efc94563f04ce789d49","text":"7.7.6","text_display":"\n7.7.6","confidence":1,"confidence_rate":1},{"cnt":[[571,1272],[904,1272],[904,1313],[571,1313]],"region":{"top_left_x":571,"top_left_y":1271,"width":334,"height":42},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e75d03dd356f4652a75cb456d1b3a29e","type":"table_of_contents_item","conversion_output":true,"parent_id":"67f80a0ba9154efc94563f04ce789d49","text":"Pain in Other Joints","text_display":" Pain in Other Joints","confidence":1,"confidence_rate":1},{"cnt":[[1706,1274],[1753,1274],[1753,1315],[1706,1315]],"region":{"top_left_x":1705,"top_left_y":1274,"width":49,"height":41},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27ce0702a30c4193a881b3cb83d7e6f7","type":"table_of_contents_number","conversion_output":true,"parent_id":"67f80a0ba9154efc94563f04ce789d49","text":"83","text_display":" ..... 83","confidence":1,"confidence_rate":1},{"cnt":[[245,1336],[1755,1336],[1755,1386],[245,1386]],"region":{"top_left_x":244,"top_left_y":1336,"width":1512,"height":50},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5da7590463634d7eb7867effb79ea81a","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["928c29ffd24442b3b47bf37d564e6252","3410cbe08dbd4531a2ffbf185f0b0d53","9f70c818f7c74dfa872f4203c7215b1c"],"text":"","text_display":""},{"cnt":[[243,1345],[275,1345],[275,1381],[243,1381]],"region":{"top_left_x":242,"top_left_y":1344,"width":33,"height":38},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"928c29ffd24442b3b47bf37d564e6252","type":"table_of_contents_item","conversion_output":true,"parent_id":"5da7590463634d7eb7867effb79ea81a","text":"8","text_display":"\n8","confidence":1,"confidence_rate":1},{"cnt":[[571,1341],[728,1341],[728,1381],[571,1381]],"region":{"top_left_x":571,"top_left_y":1340,"width":158,"height":42},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3410cbe08dbd4531a2ffbf185f0b0d53","type":"table_of_contents_item","conversion_output":true,"parent_id":"5da7590463634d7eb7867effb79ea81a","text":"Statistics","text_display":" Statistics","confidence":1,"confidence_rate":1},{"cnt":[[1706,1345],[1753,1345],[1753,1384],[1706,1384]],"region":{"top_left_x":1705,"top_left_y":1344,"width":49,"height":40},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f70c818f7c74dfa872f4203c7215b1c","type":"table_of_contents_number","conversion_output":true,"parent_id":"5da7590463634d7eb7867effb79ea81a","text":"83","text_display":" ..... 83","confidence":1,"confidence_rate":1},{"cnt":[[245,1405],[1755,1405],[1755,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1405,"width":1512,"height":54},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e2991cf9e8e4c4b943f291fb8237b0e","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["18d661d7b4fc4064bd7c352fe96b2a83","073260d300774666bc1557d9e16dee6f","b9fba839cc604cdbb290b79cf6256e6a"],"text":"","text_display":""},{"cnt":[[249,1409],[303,1409],[303,1450],[249,1450]],"region":{"top_left_x":249,"top_left_y":1409,"width":54,"height":42},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18d661d7b4fc4064bd7c352fe96b2a83","type":"table_of_contents_item","conversion_output":true,"parent_id":"0e2991cf9e8e4c4b943f291fb8237b0e","text":"8.1","text_display":"\n8.1","confidence":1,"confidence_rate":1},{"cnt":[[571,1409],[784,1409],[784,1454],[571,1454]],"region":{"top_left_x":571,"top_left_y":1409,"width":214,"height":46},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"073260d300774666bc1557d9e16dee6f","type":"table_of_contents_item","conversion_output":true,"parent_id":"0e2991cf9e8e4c4b943f291fb8237b0e","text":"Sample Size","text_display":" Sample Size","confidence":1,"confidence_rate":1},{"cnt":[[1706,1409],[1753,1409],[1753,1450],[1706,1450]],"region":{"top_left_x":1705,"top_left_y":1409,"width":49,"height":42},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9fba839cc604cdbb290b79cf6256e6a","type":"table_of_contents_number","conversion_output":true,"parent_id":"0e2991cf9e8e4c4b943f291fb8237b0e","text":"83","text_display":" ..... 83","confidence":1,"confidence_rate":1},{"cnt":[[245,1474],[1755,1474],[1755,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1473,"width":1512,"height":51},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2b8ec607a1a4966ad6a45ac7f325519","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["2829b95babf64e959aaf0aef49c7c574","033de904565d4d7bb537153a6c34cc93","5483e774cacc43ada4c776c0ac7bbff8"],"text":"","text_display":""},{"cnt":[[249,1478],[305,1478],[305,1519],[249,1519]],"region":{"top_left_x":249,"top_left_y":1478,"width":57,"height":41},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2829b95babf64e959aaf0aef49c7c574","type":"table_of_contents_item","conversion_output":true,"parent_id":"e2b8ec607a1a4966ad6a45ac7f325519","text":"8.2","text_display":"\n8.2","confidence":1,"confidence_rate":1},{"cnt":[[571,1478],[831,1478],[831,1519],[571,1519]],"region":{"top_left_x":571,"top_left_y":1478,"width":261,"height":41},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"033de904565d4d7bb537153a6c34cc93","type":"table_of_contents_item","conversion_output":true,"parent_id":"e2b8ec607a1a4966ad6a45ac7f325519","text":"Randomization","text_display":" Randomization","confidence":1,"confidence_rate":1},{"cnt":[[1706,1478],[1757,1478],[1757,1519],[1706,1519]],"region":{"top_left_x":1705,"top_left_y":1478,"width":53,"height":41},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5483e774cacc43ada4c776c0ac7bbff8","type":"table_of_contents_number","conversion_output":true,"parent_id":"e2b8ec607a1a4966ad6a45ac7f325519","text":"86","text_display":" ..... 86","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1755,1543],[1755,1596],[245,1596]],"region":{"top_left_x":244,"top_left_y":1542,"width":1512,"height":55},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"533cfd393dcc4dc9889c3d877fc2ac25","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["601086af9b0d4178a05c9933a633823d","e20bba7df6884e39ad6920dfe9fbbfcf","3e42fe0bd0c34cecba4ed93da5489dcf"],"text":"","text_display":""},{"cnt":[[249,1549],[305,1549],[305,1590],[249,1590]],"region":{"top_left_x":249,"top_left_y":1549,"width":57,"height":41},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"601086af9b0d4178a05c9933a633823d","type":"table_of_contents_item","conversion_output":true,"parent_id":"533cfd393dcc4dc9889c3d877fc2ac25","text":"8.3","text_display":"\n8.3","confidence":1,"confidence_rate":1},{"cnt":[[571,1547],[746,1547],[746,1594],[571,1594]],"region":{"top_left_x":571,"top_left_y":1546,"width":175,"height":49},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e20bba7df6884e39ad6920dfe9fbbfcf","type":"table_of_contents_item","conversion_output":true,"parent_id":"533cfd393dcc4dc9889c3d877fc2ac25","text":"Endpoints","text_display":" Endpoints","confidence":1,"confidence_rate":1},{"cnt":[[1706,1547],[1757,1547],[1757,1588],[1706,1588]],"region":{"top_left_x":1705,"top_left_y":1546,"width":53,"height":42},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e42fe0bd0c34cecba4ed93da5489dcf","type":"table_of_contents_number","conversion_output":true,"parent_id":"533cfd393dcc4dc9889c3d877fc2ac25","text":"86","text_display":" ..... 86","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1755,1611],[1755,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1611,"width":1512,"height":55},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd0c6dcb09a347d7a95f8d0991a429be","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["8436108488ce466cbaf23e306e0d9369","2d7c1b288d1549eaa84b0421db6cea5a","7dd27b6d78db473195f657be2414538c"],"text":"","text_display":""},{"cnt":[[249,1618],[333,1618],[333,1656],[249,1656]],"region":{"top_left_x":249,"top_left_y":1617,"width":85,"height":40},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8436108488ce466cbaf23e306e0d9369","type":"table_of_contents_item","conversion_output":true,"parent_id":"cd0c6dcb09a347d7a95f8d0991a429be","text":"8.3.1","text_display":"\n8.3.1","confidence":1,"confidence_rate":1},{"cnt":[[571,1616],[874,1616],[874,1663],[571,1663]],"region":{"top_left_x":571,"top_left_y":1615,"width":304,"height":48},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d7c1b288d1549eaa84b0421db6cea5a","type":"table_of_contents_item","conversion_output":true,"parent_id":"cd0c6dcb09a347d7a95f8d0991a429be","text":"Primary Endpoint","text_display":" Primary Endpoint","confidence":1,"confidence_rate":1},{"cnt":[[1706,1616],[1757,1616],[1757,1659],[1706,1659]],"region":{"top_left_x":1705,"top_left_y":1615,"width":53,"height":44},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7dd27b6d78db473195f657be2414538c","type":"table_of_contents_number","conversion_output":true,"parent_id":"cd0c6dcb09a347d7a95f8d0991a429be","text":"86","text_display":" ..... 86","confidence":1,"confidence_rate":1},{"cnt":[[245,1680],[1755,1680],[1755,1734],[245,1734]],"region":{"top_left_x":244,"top_left_y":1680,"width":1512,"height":54},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f610631152364c628d53c02c369b7a5f","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["208c422ff5bd46418ce2e2bc097686ee","3b34b156f6ff4a2792f9467b9660881e","87d68818eea245d88155b88ae3b5ab4d"],"text":"","text_display":""},{"cnt":[[249,1684],[333,1684],[333,1725],[249,1725]],"region":{"top_left_x":249,"top_left_y":1684,"width":85,"height":42},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"208c422ff5bd46418ce2e2bc097686ee","type":"table_of_contents_item","conversion_output":true,"parent_id":"f610631152364c628d53c02c369b7a5f","text":"8.3.2","text_display":"\n8.3.2","confidence":1,"confidence_rate":1},{"cnt":[[571,1684],[930,1684],[930,1729],[571,1729]],"region":{"top_left_x":571,"top_left_y":1684,"width":360,"height":46},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b34b156f6ff4a2792f9467b9660881e","type":"table_of_contents_item","conversion_output":true,"parent_id":"f610631152364c628d53c02c369b7a5f","text":"Secondary Endpoints","text_display":" Secondary Endpoints","confidence":1,"confidence_rate":1},{"cnt":[[1706,1684],[1757,1684],[1757,1723],[1706,1723]],"region":{"top_left_x":1705,"top_left_y":1684,"width":53,"height":40},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87d68818eea245d88155b88ae3b5ab4d","type":"table_of_contents_number","conversion_output":true,"parent_id":"f610631152364c628d53c02c369b7a5f","text":"86","text_display":" ..... 86","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1755,1749],[1755,1803],[245,1803]],"region":{"top_left_x":244,"top_left_y":1748,"width":1512,"height":55},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2642071a33c84425aec0fe9d3b5a8d44","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["5d3734d031d74326bb75e49906133bbc","9a8112ca485547c483009059a94ba455","542c4d380aa041d2a0bdc55f83f24225"],"text":"","text_display":""},{"cnt":[[249,1753],[333,1753],[333,1794],[249,1794]],"region":{"top_left_x":249,"top_left_y":1753,"width":85,"height":41},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d3734d031d74326bb75e49906133bbc","type":"table_of_contents_item","conversion_output":true,"parent_id":"2642071a33c84425aec0fe9d3b5a8d44","text":"8.3.3","text_display":"\n8.3.3","confidence":1,"confidence_rate":1},{"cnt":[[571,1753],[862,1753],[862,1798],[571,1798]],"region":{"top_left_x":571,"top_left_y":1753,"width":291,"height":46},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a8112ca485547c483009059a94ba455","type":"table_of_contents_item","conversion_output":true,"parent_id":"2642071a33c84425aec0fe9d3b5a8d44","text":"Safety Endpoints","text_display":" Safety Endpoints","confidence":1,"confidence_rate":1},{"cnt":[[1706,1753],[1753,1753],[1753,1796],[1706,1796]],"region":{"top_left_x":1705,"top_left_y":1753,"width":49,"height":44},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"542c4d380aa041d2a0bdc55f83f24225","type":"table_of_contents_number","conversion_output":true,"parent_id":"2642071a33c84425aec0fe9d3b5a8d44","text":"87","text_display":" ..... 87","confidence":1,"confidence_rate":1},{"cnt":[[245,1818],[1755,1818],[1755,1871],[245,1871]],"region":{"top_left_x":244,"top_left_y":1817,"width":1512,"height":55},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9034283502e940148eea5c26290bf561","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["f448b3b411a7451890991f7c9d592ec7","ac1e4f39bcbb4de49d465f1b531e1b81","051a4494f6c2480aa6af32423f4092f9"],"text":"","text_display":""},{"cnt":[[249,1822],[335,1822],[335,1863],[249,1863]],"region":{"top_left_x":249,"top_left_y":1821,"width":87,"height":42},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f448b3b411a7451890991f7c9d592ec7","type":"table_of_contents_item","conversion_output":true,"parent_id":"9034283502e940148eea5c26290bf561","text":"8.3.4","text_display":"\n8.3.4","confidence":1,"confidence_rate":1},{"cnt":[[571,1822],[954,1822],[954,1869],[571,1869]],"region":{"top_left_x":571,"top_left_y":1821,"width":383,"height":49},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac1e4f39bcbb4de49d465f1b531e1b81","type":"table_of_contents_item","conversion_output":true,"parent_id":"9034283502e940148eea5c26290bf561","text":"Exploratory Endpoints","text_display":" Exploratory Endpoints","confidence":1,"confidence_rate":1},{"cnt":[[1706,1824],[1753,1824],[1753,1867],[1706,1867]],"region":{"top_left_x":1705,"top_left_y":1824,"width":49,"height":43},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"051a4494f6c2480aa6af32423f4092f9","type":"table_of_contents_number","conversion_output":true,"parent_id":"9034283502e940148eea5c26290bf561","text":"87","text_display":" ..... 87","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1755,1886],[1755,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1886,"width":1512,"height":59},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a050cd382aa420cbf59d524ccdf6c49","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["0ee5c94833424c6983e38b833e72a65b","1a03e1bdca494c7dba89f891161aed21","56f77c4dc65344c8b8d95436ad8002ef"],"text":"","text_display":""},{"cnt":[[249,1893],[305,1893],[305,1934],[249,1934]],"region":{"top_left_x":249,"top_left_y":1892,"width":57,"height":42},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ee5c94833424c6983e38b833e72a65b","type":"table_of_contents_item","conversion_output":true,"parent_id":"7a050cd382aa420cbf59d524ccdf6c49","text":"8.4","text_display":"\n8.4","confidence":1,"confidence_rate":1},{"cnt":[[571,1891],[801,1891],[801,1938],[571,1938]],"region":{"top_left_x":571,"top_left_y":1890,"width":231,"height":48},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a03e1bdca494c7dba89f891161aed21","type":"table_of_contents_item","conversion_output":true,"parent_id":"7a050cd382aa420cbf59d524ccdf6c49","text":"Analysis Sets","text_display":" Analysis Sets","confidence":1,"confidence_rate":1},{"cnt":[[1706,1895],[1753,1895],[1753,1936],[1706,1936]],"region":{"top_left_x":1705,"top_left_y":1894,"width":49,"height":42},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56f77c4dc65344c8b8d95436ad8002ef","type":"table_of_contents_number","conversion_output":true,"parent_id":"7a050cd382aa420cbf59d524ccdf6c49","text":"88","text_display":" ..... 88","confidence":1,"confidence_rate":1},{"cnt":[[245,1955],[1755,1955],[1755,2009],[245,2009]],"region":{"top_left_x":244,"top_left_y":1955,"width":1512,"height":54},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f983bf10cf334e349003fba0dc79acdd","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["c0a6e8e167f348f68695663df0abfd12","2aefd677480d439c9e5d244e70bc540b","19a14221e49b40c7a44588d43db14bbf"],"text":"","text_display":""},{"cnt":[[249,1959],[305,1959],[305,2000],[249,2000]],"region":{"top_left_x":249,"top_left_y":1959,"width":57,"height":42},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0a6e8e167f348f68695663df0abfd12","type":"table_of_contents_item","conversion_output":true,"parent_id":"f983bf10cf334e349003fba0dc79acdd","text":"8.5","text_display":"\n8.5","confidence":1,"confidence_rate":1},{"cnt":[[571,1959],[1154,1959],[1154,2004],[571,2004]],"region":{"top_left_x":571,"top_left_y":1959,"width":583,"height":46},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2aefd677480d439c9e5d244e70bc540b","type":"table_of_contents_item","conversion_output":true,"parent_id":"f983bf10cf334e349003fba0dc79acdd","text":"Description of Statistical Analyses","text_display":" Description of Statistical Analyses","confidence":1,"confidence_rate":1},{"cnt":[[1706,1959],[1753,1959],[1753,2000],[1706,2000]],"region":{"top_left_x":1705,"top_left_y":1959,"width":49,"height":42},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19a14221e49b40c7a44588d43db14bbf","type":"table_of_contents_number","conversion_output":true,"parent_id":"f983bf10cf334e349003fba0dc79acdd","text":"89","text_display":" ..... 89","confidence":1,"confidence_rate":1},{"cnt":[[245,2024],[1755,2024],[1755,2073],[245,2073]],"region":{"top_left_x":244,"top_left_y":2023,"width":1512,"height":51},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db0f6b1438644dd98bf75ca9d2ce351b","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["1dba50e7e2854b9d9a11ba8de383a466","1dadc7ba069f4061a3f01a78b0b7603f","be36e9b65203400aab3f78c8dd26715f"],"text":"","text_display":""},{"cnt":[[249,2028],[333,2028],[333,2069],[249,2069]],"region":{"top_left_x":249,"top_left_y":2028,"width":85,"height":41},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dba50e7e2854b9d9a11ba8de383a466","type":"table_of_contents_item","conversion_output":true,"parent_id":"db0f6b1438644dd98bf75ca9d2ce351b","text":"8.5.1","text_display":"\n8.5.1","confidence":1,"confidence_rate":1},{"cnt":[[571,2028],[969,2028],[969,2069],[571,2069]],"region":{"top_left_x":571,"top_left_y":2028,"width":398,"height":41},"line":105,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dadc7ba069f4061a3f01a78b0b7603f","type":"table_of_contents_item","conversion_output":true,"parent_id":"db0f6b1438644dd98bf75ca9d2ce351b","text":"General Considerations","text_display":" General Considerations","confidence":1,"confidence_rate":1},{"cnt":[[1706,2028],[1753,2028],[1753,2069],[1706,2069]],"region":{"top_left_x":1705,"top_left_y":2028,"width":49,"height":41},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be36e9b65203400aab3f78c8dd26715f","type":"table_of_contents_number","conversion_output":true,"parent_id":"db0f6b1438644dd98bf75ca9d2ce351b","text":"89","text_display":" ..... 89","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1755,2093],[1755,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2092,"width":1512,"height":55},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e49c834373864c8aa5eafc78867ea24d","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["49792389ef0d48408ec9073a1722a1b2","71a0d303a4fe40f0babf5052fc8cbd42","eb638e3bbbf549429500fb030973b670"],"text":"","text_display":""},{"cnt":[[249,2097],[333,2097],[333,2138],[249,2138]],"region":{"top_left_x":249,"top_left_y":2096,"width":85,"height":42},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49792389ef0d48408ec9073a1722a1b2","type":"table_of_contents_item","conversion_output":true,"parent_id":"e49c834373864c8aa5eafc78867ea24d","text":"8.5.2","text_display":"\n8.5.2","confidence":1,"confidence_rate":1},{"cnt":[[571,2097],[1076,2097],[1076,2142],[571,2142]],"region":{"top_left_x":571,"top_left_y":2096,"width":506,"height":46},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71a0d303a4fe40f0babf5052fc8cbd42","type":"table_of_contents_item","conversion_output":true,"parent_id":"e49c834373864c8aa5eafc78867ea24d","text":"Analysis of Primary Endpoint","text_display":" Analysis of Primary Endpoint","confidence":1,"confidence_rate":1},{"cnt":[[1706,2099],[1753,2099],[1753,2142],[1706,2142]],"region":{"top_left_x":1705,"top_left_y":2099,"width":49,"height":43},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb638e3bbbf549429500fb030973b670","type":"table_of_contents_number","conversion_output":true,"parent_id":"e49c834373864c8aa5eafc78867ea24d","text":"90","text_display":" ..... 90","confidence":1,"confidence_rate":1},{"cnt":[[245,2161],[1755,2161],[1755,2219],[245,2219]],"region":{"top_left_x":244,"top_left_y":2161,"width":1512,"height":59},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f3db0faa7804d998d6b3593e2710fae","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["44f6e89de3c64c66a94666caa7d176f8","c248fd27812b48a49061262fc5a1abd4","8f4cb6382dd746a3a7ca5ec44f7bc712"],"text":"","text_display":""},{"cnt":[[249,2168],[333,2168],[333,2206],[249,2206]],"region":{"top_left_x":249,"top_left_y":2167,"width":85,"height":40},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44f6e89de3c64c66a94666caa7d176f8","type":"table_of_contents_item","conversion_output":true,"parent_id":"4f3db0faa7804d998d6b3593e2710fae","text":"8.5.3","text_display":"\n8.5.3","confidence":1,"confidence_rate":1},{"cnt":[[571,2166],[1132,2166],[1132,2213],[571,2213]],"region":{"top_left_x":571,"top_left_y":2165,"width":562,"height":48},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c248fd27812b48a49061262fc5a1abd4","type":"table_of_contents_item","conversion_output":true,"parent_id":"4f3db0faa7804d998d6b3593e2710fae","text":"Analysis of Secondary Endpoints","text_display":" Analysis of Secondary Endpoints","confidence":1,"confidence_rate":1},{"cnt":[[1706,2170],[1749,2170],[1749,2213],[1706,2213]],"region":{"top_left_x":1705,"top_left_y":2169,"width":44,"height":44},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f4cb6382dd746a3a7ca5ec44f7bc712","type":"table_of_contents_number","conversion_output":true,"parent_id":"4f3db0faa7804d998d6b3593e2710fae","text":"91","text_display":" ..... 91","confidence":1,"confidence_rate":1},{"cnt":[[243,2230],[1755,2230],[1755,2284],[243,2284]],"region":{"top_left_x":242,"top_left_y":2230,"width":1514,"height":54},"line":115,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16075f9e52b344d8b67d77dddfecb305","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["ee22b5ab1b824ca3ae9d31024783958d","635c4a3d288241988536a80f716d2b4b","db7fea3cae894b94afddaac4b419da80"],"text":"","text_display":""},{"cnt":[[249,2234],[333,2234],[333,2275],[249,2275]],"region":{"top_left_x":249,"top_left_y":2234,"width":85,"height":42},"line":116,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee22b5ab1b824ca3ae9d31024783958d","type":"table_of_contents_item","conversion_output":true,"parent_id":"16075f9e52b344d8b67d77dddfecb305","text":"8.5.4","text_display":"\n8.5.4","confidence":1,"confidence_rate":1},{"cnt":[[571,2234],[844,2234],[844,2279],[571,2279]],"region":{"top_left_x":571,"top_left_y":2234,"width":274,"height":46},"line":117,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"635c4a3d288241988536a80f716d2b4b","type":"table_of_contents_item","conversion_output":true,"parent_id":"16075f9e52b344d8b67d77dddfecb305","text":"Safety Analyses","text_display":" Safety Analyses","confidence":1,"confidence_rate":1},{"cnt":[[1706,2234],[1753,2234],[1753,2282],[1706,2282]],"region":{"top_left_x":1705,"top_left_y":2234,"width":49,"height":48},"line":118,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db7fea3cae894b94afddaac4b419da80","type":"table_of_contents_number","conversion_output":true,"parent_id":"16075f9e52b344d8b67d77dddfecb305","text":"92","text_display":" ..... 92","confidence":1,"confidence_rate":1},{"cnt":[[243,2299],[1755,2299],[1755,2357],[243,2357]],"region":{"top_left_x":242,"top_left_y":2298,"width":1514,"height":59},"line":119,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3061351519c644cfb97ea0dcad8bf8d5","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["5ee1a115b5ae45d49b736a541af9cc1c","a356a42f7ae642768aae67e633cb36a3","8f6f870388d24a859deab1cf0ce90346"],"text":"","text_display":""},{"cnt":[[249,2303],[333,2303],[333,2344],[249,2344]],"region":{"top_left_x":249,"top_left_y":2303,"width":85,"height":41},"line":120,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ee1a115b5ae45d49b736a541af9cc1c","type":"table_of_contents_item","conversion_output":true,"parent_id":"3061351519c644cfb97ea0dcad8bf8d5","text":"8.5.5","text_display":"\n8.5.5","confidence":1,"confidence_rate":1},{"cnt":[[571,2303],[1079,2303],[1079,2350],[571,2350]],"region":{"top_left_x":571,"top_left_y":2303,"width":508,"height":48},"line":121,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a356a42f7ae642768aae67e633cb36a3","type":"table_of_contents_item","conversion_output":true,"parent_id":"3061351519c644cfb97ea0dcad8bf8d5","text":"Analysis of Further Endpoints","text_display":" Analysis of Further Endpoints","confidence":1,"confidence_rate":1},{"cnt":[[1706,2303],[1753,2303],[1753,2350],[1706,2350]],"region":{"top_left_x":1705,"top_left_y":2303,"width":49,"height":48},"line":122,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f6f870388d24a859deab1cf0ce90346","type":"table_of_contents_number","conversion_output":true,"parent_id":"3061351519c644cfb97ea0dcad8bf8d5","text":"92","text_display":" ..... 92","confidence":1,"confidence_rate":1},{"cnt":[[243,2368],[1755,2368],[1755,2426],[243,2426]],"region":{"top_left_x":242,"top_left_y":2367,"width":1514,"height":59},"line":123,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c54d63f24ee54fa1b21bcae14f2ae944","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["09728c0696434f3988525b7e1920f04c","5417163d494e4d04a1a66642dd42067f","31b7565c9e2d4d18ac4b7379ef7c187e"],"text":"","text_display":""},{"cnt":[[249,2372],[305,2372],[305,2415],[249,2415]],"region":{"top_left_x":249,"top_left_y":2371,"width":57,"height":44},"line":124,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09728c0696434f3988525b7e1920f04c","type":"table_of_contents_item","conversion_output":true,"parent_id":"c54d63f24ee54fa1b21bcae14f2ae944","text":"8.6","text_display":"\n8.6","confidence":1,"confidence_rate":1},{"cnt":[[571,2372],[853,2372],[853,2419],[571,2419]],"region":{"top_left_x":571,"top_left_y":2371,"width":282,"height":49},"line":125,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5417163d494e4d04a1a66642dd42067f","type":"table_of_contents_item","conversion_output":true,"parent_id":"c54d63f24ee54fa1b21bcae14f2ae944","text":"Interim Analysis","text_display":" Interim Analysis","confidence":1,"confidence_rate":1},{"cnt":[[1706,2372],[1753,2372],[1753,2415],[1706,2415]],"region":{"top_left_x":1705,"top_left_y":2371,"width":49,"height":44},"line":126,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31b7565c9e2d4d18ac4b7379ef7c187e","type":"table_of_contents_number","conversion_output":true,"parent_id":"c54d63f24ee54fa1b21bcae14f2ae944","text":"93","text_display":" ..... 93","confidence":1,"confidence_rate":1},{"cnt":[[243,2436],[1755,2436],[1755,2490],[243,2490]],"region":{"top_left_x":242,"top_left_y":2436,"width":1514,"height":55},"line":127,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e67f18f433c4e1a9fa59b1109a5915d","type":"table_of_contents_row","conversion_output":false,"parent_id":"bd1af96ca3dc4fd19c5d471e2dc32b9d","children_ids":["bd872e65fb3e43c886d6429e062ebd18","81d70195a1ff44d1bffc048b709a9142","365e49383ac6458a8ba02b99f43b452a"],"text":"","text_display":""},{"cnt":[[243,2445],[275,2445],[275,2488],[243,2488]],"region":{"top_left_x":242,"top_left_y":2444,"width":33,"height":44},"line":128,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd872e65fb3e43c886d6429e062ebd18","type":"table_of_contents_item","conversion_output":true,"parent_id":"9e67f18f433c4e1a9fa59b1109a5915d","text":"9","text_display":"\n9","confidence":1,"confidence_rate":1},{"cnt":[[571,2441],[1102,2441],[1102,2488],[571,2488]],"region":{"top_left_x":571,"top_left_y":2440,"width":532,"height":48},"line":129,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81d70195a1ff44d1bffc048b709a9142","type":"table_of_contents_item","conversion_output":true,"parent_id":"9e67f18f433c4e1a9fa59b1109a5915d","text":"Ethical and Regulatory Aspects","text_display":" Ethical and Regulatory Aspects","confidence":1,"confidence_rate":1},{"cnt":[[1706,2445],[1753,2445],[1753,2488],[1706,2488]],"region":{"top_left_x":1705,"top_left_y":2444,"width":49,"height":44},"line":130,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"365e49383ac6458a8ba02b99f43b452a","type":"table_of_contents_number","conversion_output":true,"parent_id":"9e67f18f433c4e1a9fa59b1109a5915d","text":"93","text_display":" ..... 93","confidence":1,"confidence_rate":1},{"cnt":[[247,2514],[432,2514],[432,2542],[247,2542]],"region":{"top_left_x":247,"top_left_y":2513,"width":185,"height":29},"line":131,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ef80514c53294c23843c91686ff2ebf7","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[447,2509],[507,2509],[507,2548],[447,2548]],"region":{"top_left_x":446,"top_left_y":2509,"width":62,"height":40},"line":132,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f53bf452583745aa86bceadb96993c20","type":"page_info","conversion_output":false,"text":"CCI","text_display":"","confidence":0.8825968643650413,"confidence_rate":0.9845103757427297},{"cnt":[[1525,2531],[1603,2531],[1603,2565],[1525,2565]],"region":{"top_left_x":1525,"top_left_y":2530,"width":78,"height":36},"line":133,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98d5b1d9cff8415291dff73173bd795a","type":"page_info","conversion_output":false,"text":"9/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[385,2548],[385,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":141,"height":37},"line":134,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a49b6ad164f641a98f70b859aa10de68","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99853515625,"confidence_rate":0.9999022769297106}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-010","page":10,"lines":[{"cnt":[[245,129],[434,129],[434,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":190,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f00abb3f16f43db90a5a641f6bb0470","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,127],[1317,127],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":126,"width":673,"height":49},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49e7fa0d60c349178317a380455e9b2b","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c82e1a302374e378d2ddd84d09feb92","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[232,269],[1766,269],[1766,2069],[232,2069]],"region":{"top_left_x":232,"top_left_y":268,"width":1535,"height":1801},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f66dc8df742c43889208e087ea26a734","type":"table_of_contents_container","conversion_output":false,"children_ids":["e342964f157340abbe8c59738195af24","b7c9c434006642bc83e9e9d2f8c26bd0","9ce6e9ed3edb4587b296477dfa93ceb3","4c59a05a1310408aa7078109fbeabe63","6c25714f6e7c4f5fb642d8adf81aae20","02ef6caf86294be5805d2b397c20822f","b484c256a5214c7eb4031bbed86df12a","8a446025bb3742ffac074055157f8062","af059b820d364d6f960b0fd2c3e120f1","d8239d73a7444db894669872a3f3bb5e","10cb8e8c9acb4c56bcc37b734cf1698b","6c234d5890a546539f5a737e9a1d6ffa","8fc2ccb32daa4dd48a1fb482f2308094","d748cd0c9e3f423e98b7c60510cef08d","849d20d95ead43bd9015d68a27b5a38b","04c578c85bce44d3aa979311c5940ff6","da710f7f5e704f2c8c7207dc4aabb490","8ead000e42a645368e12e6d134e6315d","c62d021d59254925b519ae426922678f","8695af532ea649ce8902b37934adf638","d218586c20de4604926d0eb38626ccc6","2175fb19873d4babac9f9063c8e0ff30","c8abcfdb8213449dacb5347c6f94ca0b","beb47821626e47cfa2601a85237434f7"],"text":"","text_display":""},{"cnt":[[243,275],[1760,275],[1760,337],[243,337]],"region":{"top_left_x":242,"top_left_y":275,"width":1518,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e342964f157340abbe8c59738195af24","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["edba0cd5759c455eabf22a800148b3c8","ac55e1b5d96f48a18d5de1bd184b5ad7"],"text":"","text_display":""},{"cnt":[[245,281],[1162,281],[1162,329],[245,329]],"region":{"top_left_x":244,"top_left_y":281,"width":919,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edba0cd5759c455eabf22a800148b3c8","type":"table_of_contents_item","conversion_output":true,"parent_id":"e342964f157340abbe8c59738195af24","text":"9.1 Responsibilities of the Investigator","text_display":"\n9.1 Responsibilities of the Investigator","confidence":1,"confidence_rate":1},{"cnt":[[1706,277],[1753,277],[1753,322],[1706,322]],"region":{"top_left_x":1705,"top_left_y":277,"width":49,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac55e1b5d96f48a18d5de1bd184b5ad7","type":"table_of_contents_number","conversion_output":true,"parent_id":"e342964f157340abbe8c59738195af24","text":"93","text_display":" ..... 93","confidence":1,"confidence_rate":1},{"cnt":[[243,346],[1757,346],[1757,404],[243,404]],"region":{"top_left_x":242,"top_left_y":345,"width":1516,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7c9c434006642bc83e9e9d2f8c26bd0","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["dac636814e574c38975a0d0bb45844cc","369237819ff34dd6bc9136cb6cf22c53"],"text":"","text_display":""},{"cnt":[[245,352],[1296,352],[1296,400],[245,400]],"region":{"top_left_x":244,"top_left_y":352,"width":1052,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dac636814e574c38975a0d0bb45844cc","type":"table_of_contents_item","conversion_output":true,"parent_id":"b7c9c434006642bc83e9e9d2f8c26bd0","text":"9.2 Subject Information and Informed Consent","text_display":"\n9.2 Subject Information and Informed Consent","confidence":1,"confidence_rate":1},{"cnt":[[1706,346],[1764,346],[1764,391],[1706,391]],"region":{"top_left_x":1705,"top_left_y":345,"width":59,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"369237819ff34dd6bc9136cb6cf22c53","type":"table_of_contents_number","conversion_output":true,"parent_id":"b7c9c434006642bc83e9e9d2f8c26bd0","text":"94","text_display":" ..... 94","confidence":1,"confidence_rate":1},{"cnt":[[243,415],[1755,415],[1755,473],[243,473]],"region":{"top_left_x":242,"top_left_y":414,"width":1514,"height":59},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ce6e9ed3edb4587b296477dfa93ceb3","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["f31ce91ebb584f299143298c077d3770","45ffc505083b40eba653f7b8a79cf5ee"],"text":"","text_display":""},{"cnt":[[245,421],[1145,421],[1145,468],[245,468]],"region":{"top_left_x":244,"top_left_y":421,"width":902,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f31ce91ebb584f299143298c077d3770","type":"table_of_contents_item","conversion_output":true,"parent_id":"9ce6e9ed3edb4587b296477dfa93ceb3","text":"9.3 Subject Identification and Privacy","text_display":"\n9.3 Subject Identification and Privacy","confidence":0.99951171875,"confidence_rate":0.9999886419133848},{"cnt":[[1706,415],[1753,415],[1753,460],[1706,460]],"region":{"top_left_x":1705,"top_left_y":414,"width":49,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45ffc505083b40eba653f7b8a79cf5ee","type":"table_of_contents_number","conversion_output":true,"parent_id":"9ce6e9ed3edb4587b296477dfa93ceb3","text":"95","text_display":" ..... 95","confidence":1,"confidence_rate":1},{"cnt":[[243,483],[1755,483],[1755,539],[243,539]],"region":{"top_left_x":242,"top_left_y":483,"width":1514,"height":57},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c59a05a1310408aa7078109fbeabe63","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["9410f1a645dc48f79af07edc14b23a8e","0239fb8351734acdb994cfdcc5a11724"],"text":"","text_display":""},{"cnt":[[245,490],[1354,490],[1354,535],[245,535]],"region":{"top_left_x":244,"top_left_y":489,"width":1110,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9410f1a645dc48f79af07edc14b23a8e","type":"table_of_contents_item","conversion_output":true,"parent_id":"4c59a05a1310408aa7078109fbeabe63","text":"9.4 Emergency Medical Support and Subject Card","text_display":"\n9.4 Emergency Medical Support and Subject Card","confidence":1,"confidence_rate":1},{"cnt":[[1706,483],[1753,483],[1753,529],[1706,529]],"region":{"top_left_x":1705,"top_left_y":483,"width":49,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0239fb8351734acdb994cfdcc5a11724","type":"table_of_contents_number","conversion_output":true,"parent_id":"4c59a05a1310408aa7078109fbeabe63","text":"95","text_display":" ..... 95","confidence":1,"confidence_rate":1},{"cnt":[[243,552],[1755,552],[1755,608],[243,608]],"region":{"top_left_x":242,"top_left_y":552,"width":1514,"height":57},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c25714f6e7c4f5fb642d8adf81aae20","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["a26ac38169a741878824b456af662e9d","39cf20bc5f4d402aaa23b9c9ce787b8d"],"text":"","text_display":""},{"cnt":[[247,559],[1489,559],[1489,604],[247,604]],"region":{"top_left_x":247,"top_left_y":558,"width":1242,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a26ac38169a741878824b456af662e9d","type":"table_of_contents_item","conversion_output":true,"parent_id":"6c25714f6e7c4f5fb642d8adf81aae20","text":"9.5 Clinical Trial Insurance and Compensation to Subjects","text_display":"\n9.5 Clinical Trial Insurance and Compensation to Subjects","confidence":1,"confidence_rate":1},{"cnt":[[1706,552],[1764,552],[1764,597],[1706,597]],"region":{"top_left_x":1705,"top_left_y":552,"width":59,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39cf20bc5f4d402aaa23b9c9ce787b8d","type":"table_of_contents_number","conversion_output":true,"parent_id":"6c25714f6e7c4f5fb642d8adf81aae20","text":"96","text_display":" ..... 96","confidence":1,"confidence_rate":1},{"cnt":[[243,623],[1755,623],[1755,677],[243,677]],"region":{"top_left_x":242,"top_left_y":623,"width":1514,"height":54},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02ef6caf86294be5805d2b397c20822f","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["ad7167b4f19142f18d75386c8a9283f5","dd0aabe3aed142a495a967e8e867c792"],"text":"","text_display":""},{"cnt":[[247,627],[1601,627],[1601,672],[247,672]],"region":{"top_left_x":247,"top_left_y":627,"width":1354,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad7167b4f19142f18d75386c8a9283f5","type":"table_of_contents_item","conversion_output":true,"parent_id":"02ef6caf86294be5805d2b397c20822f","text":"9.6 Independent Ethics Committee or Institutional Review Board","text_display":"\n9.6 Independent Ethics Committee or Institutional Review Board","confidence":0.99951171875,"confidence_rate":0.9999927104668955},{"cnt":[[1706,623],[1764,623],[1764,666],[1706,666]],"region":{"top_left_x":1705,"top_left_y":623,"width":59,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd0aabe3aed142a495a967e8e867c792","type":"table_of_contents_number","conversion_output":true,"parent_id":"02ef6caf86294be5805d2b397c20822f","text":"96","text_display":" ..... 96","confidence":1,"confidence_rate":1},{"cnt":[[243,692],[1755,692],[1755,741],[243,741]],"region":{"top_left_x":242,"top_left_y":691,"width":1514,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b484c256a5214c7eb4031bbed86df12a","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["7a85e9b4d8954dd3a1bf6fdff2530ea2","4ab51d27c45d47eda2f23a74d658205d"],"text":"","text_display":""},{"cnt":[[247,696],[887,696],[887,737],[247,737]],"region":{"top_left_x":247,"top_left_y":696,"width":641,"height":41},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a85e9b4d8954dd3a1bf6fdff2530ea2","type":"table_of_contents_item","conversion_output":true,"parent_id":"b484c256a5214c7eb4031bbed86df12a","text":"9.7 Health Authorities","text_display":"\n9.7 Health Authorities","confidence":1,"confidence_rate":1},{"cnt":[[1706,692],[1753,692],[1753,735],[1706,735]],"region":{"top_left_x":1705,"top_left_y":691,"width":49,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ab51d27c45d47eda2f23a74d658205d","type":"table_of_contents_number","conversion_output":true,"parent_id":"b484c256a5214c7eb4031bbed86df12a","text":"97","text_display":" ..... 97","confidence":1,"confidence_rate":1},{"cnt":[[245,761],[1755,761],[1755,814],[245,814]],"region":{"top_left_x":244,"top_left_y":760,"width":1512,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a446025bb3742ffac074055157f8062","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["345dd088ec42415c89238a5c1a127f92","4b79a14418de4f39883c68dcc42df367"],"text":"","text_display":""},{"cnt":[[251,765],[887,765],[887,810],[251,810]],"region":{"top_left_x":251,"top_left_y":764,"width":637,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"345dd088ec42415c89238a5c1a127f92","type":"table_of_contents_item","conversion_output":true,"parent_id":"8a446025bb3742ffac074055157f8062","text":"10 Trial Management","text_display":"\n10 Trial Management","confidence":1,"confidence_rate":1},{"cnt":[[1706,761],[1753,761],[1753,804],[1706,804]],"region":{"top_left_x":1705,"top_left_y":760,"width":49,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b79a14418de4f39883c68dcc42df367","type":"table_of_contents_number","conversion_output":true,"parent_id":"8a446025bb3742ffac074055157f8062","text":"97","text_display":" ..... 97","confidence":1,"confidence_rate":1},{"cnt":[[245,829],[1755,829],[1755,883],[245,883]],"region":{"top_left_x":244,"top_left_y":829,"width":1512,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af059b820d364d6f960b0fd2c3e120f1","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["480f53abfc5440a287468100de4fdb63","67fec63c136e4e08990fac189365d6bb"],"text":"","text_display":""},{"cnt":[[251,834],[1051,834],[1051,879],[251,879]],"region":{"top_left_x":251,"top_left_y":833,"width":800,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"480f53abfc5440a287468100de4fdb63","type":"table_of_contents_item","conversion_output":true,"parent_id":"af059b820d364d6f960b0fd2c3e120f1","text":"10.1 Case Report Form Handling","text_display":"\n10.1 Case Report Form Handling","confidence":0.9150390625,"confidence_rate":0.9974664000426898},{"cnt":[[1706,829],[1753,829],[1753,872],[1706,872]],"region":{"top_left_x":1705,"top_left_y":829,"width":49,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67fec63c136e4e08990fac189365d6bb","type":"table_of_contents_number","conversion_output":true,"parent_id":"af059b820d364d6f960b0fd2c3e120f1","text":"97","text_display":" ..... 97","confidence":1,"confidence_rate":1},{"cnt":[[245,898],[1755,898],[1755,952],[245,952]],"region":{"top_left_x":244,"top_left_y":898,"width":1512,"height":54},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8239d73a7444db894669872a3f3bb5e","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["9d05b86fb46f4dfda3aea0acbe864cde","6b134dc341984cfa848c0e55f09a3c13"],"text":"","text_display":""},{"cnt":[[251,902],[1081,902],[1081,947],[251,947]],"region":{"top_left_x":251,"top_left_y":902,"width":830,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d05b86fb46f4dfda3aea0acbe864cde","type":"table_of_contents_item","conversion_output":true,"parent_id":"d8239d73a7444db894669872a3f3bb5e","text":"10.2 Source Data and Subject Files","text_display":"\n10.2 Source Data and Subject Files","confidence":0.52734375,"confidence_rate":0.983726113445833},{"cnt":[[1706,898],[1753,898],[1753,941],[1706,941]],"region":{"top_left_x":1705,"top_left_y":898,"width":49,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b134dc341984cfa848c0e55f09a3c13","type":"table_of_contents_number","conversion_output":true,"parent_id":"d8239d73a7444db894669872a3f3bb5e","text":"97","text_display":" ..... 97","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1755,967],[1755,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":966,"width":1512,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10cb8e8c9acb4c56bcc37b734cf1698b","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["6028275eece34de1bda8adeb6bed4457","574aad6970a04b20a3acfe88d4bdba6d"],"text":"","text_display":""},{"cnt":[[249,971],[1179,971],[1179,1016],[249,1016]],"region":{"top_left_x":249,"top_left_y":971,"width":931,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6028275eece34de1bda8adeb6bed4457","type":"table_of_contents_item","conversion_output":true,"parent_id":"10cb8e8c9acb4c56bcc37b734cf1698b","text":"10.3 Investigator Site File and Archiving","text_display":"\n10.3 Investigator Site File and Archiving","confidence":0.8154296875,"confidence_rate":0.9955741690544205},{"cnt":[[1706,969],[1753,969],[1753,1010],[1706,1010]],"region":{"top_left_x":1705,"top_left_y":968,"width":49,"height":42},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"574aad6970a04b20a3acfe88d4bdba6d","type":"table_of_contents_number","conversion_output":true,"parent_id":"10cb8e8c9acb4c56bcc37b734cf1698b","text":"98","text_display":" ..... 98","confidence":1,"confidence_rate":1},{"cnt":[[245,1033],[1757,1033],[1757,1130],[245,1130]],"region":{"top_left_x":244,"top_left_y":1033,"width":1514,"height":98},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c234d5890a546539f5a737e9a1d6ffa","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["f05d2bec9a1146e29c28143100866778","ef9f50f7e2ad4d74bdaad33e43d2bb32","319cf173cd674d90b3a7c8af5cfc104c"],"text":"","text_display":""},{"cnt":[[251,1038],[1525,1038],[1525,1085],[251,1085]],"region":{"top_left_x":251,"top_left_y":1037,"width":1275,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f05d2bec9a1146e29c28143100866778","type":"table_of_contents_item","conversion_output":true,"parent_id":"6c234d5890a546539f5a737e9a1d6ffa","text":"10.4 Monitoring, Quality Assurance and Inspection by Health","text_display":"\n10.4 Monitoring, Quality Assurance and Inspection by Health","confidence":0.9970722198486328,"confidence_rate":0.9999534602181898},{"cnt":[[571,1087],[767,1087],[767,1126],[571,1126]],"region":{"top_left_x":571,"top_left_y":1087,"width":196,"height":39},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef9f50f7e2ad4d74bdaad33e43d2bb32","type":"table_of_contents_item","conversion_output":true,"parent_id":"6c234d5890a546539f5a737e9a1d6ffa","text":"Authorities","text_display":" Authorities","confidence":1,"confidence_rate":1},{"cnt":[[1706,1087],[1753,1087],[1753,1126],[1706,1126]],"region":{"top_left_x":1705,"top_left_y":1087,"width":49,"height":39},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"319cf173cd674d90b3a7c8af5cfc104c","type":"table_of_contents_number","conversion_output":true,"parent_id":"6c234d5890a546539f5a737e9a1d6ffa","text":"98","text_display":" ..... 98","confidence":1,"confidence_rate":1},{"cnt":[[245,1152],[1755,1152],[1755,1205],[245,1205]],"region":{"top_left_x":244,"top_left_y":1151,"width":1512,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fc2ccb32daa4dd48a1fb482f2308094","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["e2aa5956df1a4965bd96227305672f0a","f66cc60806ad45fa97dc0477e9d8b1f5"],"text":"","text_display":""},{"cnt":[[249,1156],[1210,1156],[1210,1201],[249,1201]],"region":{"top_left_x":249,"top_left_y":1155,"width":961,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2aa5956df1a4965bd96227305672f0a","type":"table_of_contents_item","conversion_output":true,"parent_id":"8fc2ccb32daa4dd48a1fb482f2308094","text":"10.5 Changes to the Clinical Trial Protocol","text_display":"\n10.5 Changes to the Clinical Trial Protocol","confidence":1,"confidence_rate":1},{"cnt":[[1706,1156],[1753,1156],[1753,1195],[1706,1195]],"region":{"top_left_x":1705,"top_left_y":1155,"width":49,"height":40},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f66cc60806ad45fa97dc0477e9d8b1f5","type":"table_of_contents_number","conversion_output":true,"parent_id":"8fc2ccb32daa4dd48a1fb482f2308094","text":"99","text_display":" ..... 99","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1755,1220],[1755,1276],[245,1276]],"region":{"top_left_x":244,"top_left_y":1220,"width":1512,"height":57},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d748cd0c9e3f423e98b7c60510cef08d","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["8e27339abb7649a2a10c48247df51dd2","d55ed13c3e25433db2c5981c0a2a67b1"],"text":"","text_display":""},{"cnt":[[249,1225],[1313,1225],[1313,1272],[249,1272]],"region":{"top_left_x":249,"top_left_y":1224,"width":1064,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e27339abb7649a2a10c48247df51dd2","type":"table_of_contents_item","conversion_output":true,"parent_id":"d748cd0c9e3f423e98b7c60510cef08d","text":"10.6 Clinical Trial Report and Publication Policy","text_display":"\n10.6 Clinical Trial Report and Publication Policy","confidence":1,"confidence_rate":1},{"cnt":[[1704,1225],[1753,1225],[1753,1263],[1704,1263]],"region":{"top_left_x":1703,"top_left_y":1224,"width":51,"height":40},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d55ed13c3e25433db2c5981c0a2a67b1","type":"table_of_contents_number","conversion_output":true,"parent_id":"d748cd0c9e3f423e98b7c60510cef08d","text":"99","text_display":" ..... 99","confidence":1,"confidence_rate":1},{"cnt":[[245,1289],[1755,1289],[1755,1345],[245,1345]],"region":{"top_left_x":244,"top_left_y":1289,"width":1512,"height":56},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"849d20d95ead43bd9015d68a27b5a38b","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["a97a6ac165ed48e98e38d0078c81e466","599952aca5da48a78678d9a7dd7fd295"],"text":"","text_display":""},{"cnt":[[249,1293],[939,1293],[939,1338],[249,1338]],"region":{"top_left_x":249,"top_left_y":1293,"width":690,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a97a6ac165ed48e98e38d0078c81e466","type":"table_of_contents_item","conversion_output":true,"parent_id":"849d20d95ead43bd9015d68a27b5a38b","text":"10.6.1 Clinical Trial Reports","text_display":"\n10.6.1 Clinical Trial Reports","confidence":1,"confidence_rate":1},{"cnt":[[1706,1293],[1753,1293],[1753,1332],[1706,1332]],"region":{"top_left_x":1705,"top_left_y":1293,"width":49,"height":40},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"599952aca5da48a78678d9a7dd7fd295","type":"table_of_contents_number","conversion_output":true,"parent_id":"849d20d95ead43bd9015d68a27b5a38b","text":"99","text_display":" ..... 99","confidence":1,"confidence_rate":1},{"cnt":[[245,1358],[1755,1358],[1755,1407],[245,1407]],"region":{"top_left_x":244,"top_left_y":1357,"width":1512,"height":51},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04c578c85bce44d3aa979311c5940ff6","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["f57ca70d20a34a21bc1295e20cf59544","1be69f7f82264ad4b961af04e75b4af7"],"text":"","text_display":""},{"cnt":[[249,1362],[767,1362],[767,1399],[249,1399]],"region":{"top_left_x":249,"top_left_y":1362,"width":518,"height":37},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f57ca70d20a34a21bc1295e20cf59544","type":"table_of_contents_item","conversion_output":true,"parent_id":"04c578c85bce44d3aa979311c5940ff6","text":"10.6.2 Publication","text_display":"\n10.6.2 Publication","confidence":1,"confidence_rate":1},{"cnt":[[1706,1362],[1753,1362],[1753,1401],[1706,1401]],"region":{"top_left_x":1705,"top_left_y":1362,"width":49,"height":39},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1be69f7f82264ad4b961af04e75b4af7","type":"table_of_contents_number","conversion_output":true,"parent_id":"04c578c85bce44d3aa979311c5940ff6","text":"99","text_display":" ..... 99","confidence":1,"confidence_rate":1},{"cnt":[[245,1427],[1755,1427],[1755,1474],[245,1474]],"region":{"top_left_x":244,"top_left_y":1426,"width":1512,"height":48},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da710f7f5e704f2c8c7207dc4aabb490","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["f04e16b3c377484bb8b85a82402eeb29","eb254f5e4a66435f8f5dff8c4fb8fe3b"],"text":"","text_display":""},{"cnt":[[249,1431],[763,1431],[763,1467],[249,1467]],"region":{"top_left_x":249,"top_left_y":1430,"width":514,"height":38},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f04e16b3c377484bb8b85a82402eeb29","type":"table_of_contents_item","conversion_output":true,"parent_id":"da710f7f5e704f2c8c7207dc4aabb490","text":"11 References","text_display":"\n11 References","confidence":1,"confidence_rate":1},{"cnt":[[1689,1431],[1753,1431],[1753,1470],[1689,1470]],"region":{"top_left_x":1688,"top_left_y":1430,"width":66,"height":40},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb254f5e4a66435f8f5dff8c4fb8fe3b","type":"table_of_contents_number","conversion_output":true,"parent_id":"da710f7f5e704f2c8c7207dc4aabb490","text":"100","text_display":" ..... 100","confidence":1,"confidence_rate":1},{"cnt":[[245,1495],[1755,1495],[1755,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1495,"width":1512,"height":55},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ead000e42a645368e12e6d134e6315d","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["cbee840d1dcd42368b30ee80167b134c","4486f6d18a124231935ddcaf94f9410a","d1e188c26992459cb5f205daad25a0b5"],"text":"","text_display":""},{"cnt":[[243,1500],[296,1500],[296,1538],[243,1538]],"region":{"top_left_x":242,"top_left_y":1499,"width":55,"height":40},"line":58,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbee840d1dcd42368b30ee80167b134c","type":"table_of_contents_item","conversion_output":true,"parent_id":"8ead000e42a645368e12e6d134e6315d","text":"12","text_display":"\n12","confidence":1,"confidence_rate":1},{"cnt":[[571,1500],[776,1500],[776,1545],[571,1545]],"region":{"top_left_x":571,"top_left_y":1499,"width":205,"height":46},"line":59,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4486f6d18a124231935ddcaf94f9410a","type":"table_of_contents_item","conversion_output":true,"parent_id":"8ead000e42a645368e12e6d134e6315d","text":"Appendices","text_display":" Appendices","confidence":1,"confidence_rate":1},{"cnt":[[1689,1500],[1764,1500],[1764,1540],[1689,1540]],"region":{"top_left_x":1688,"top_left_y":1499,"width":76,"height":42},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1e188c26992459cb5f205daad25a0b5","type":"table_of_contents_number","conversion_output":true,"parent_id":"8ead000e42a645368e12e6d134e6315d","text":"104","text_display":" ..... 104","confidence":1,"confidence_rate":1},{"cnt":[[243,1564],[1757,1564],[1757,1669],[243,1669]],"region":{"top_left_x":242,"top_left_y":1564,"width":1516,"height":106},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c62d021d59254925b519ae426922678f","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["c66af7d626ce4a7ca541e61daabb57e0","53e0aa3504544fd8ac5dfa3dc41ea3b6","50ca9feac7fa4ea5ac410f486155cba8"],"text":"","text_display":""},{"cnt":[[245,1568],[1680,1568],[1680,1613],[245,1613]],"region":{"top_left_x":244,"top_left_y":1568,"width":1437,"height":46},"line":62,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c66af7d626ce4a7ca541e61daabb57e0","type":"table_of_contents_item","conversion_output":true,"parent_id":"c62d021d59254925b519ae426922678f","text":"Appendix A: American College of Rheumatology Criteria for the Classification","text_display":"\nAppendix A: American College of Rheumatology Criteria for the Classification","confidence":0.99951171875,"confidence_rate":0.9999939703823991},{"cnt":[[571,1616],[1300,1616],[1300,1663],[571,1663]],"region":{"top_left_x":571,"top_left_y":1615,"width":729,"height":48},"line":63,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53e0aa3504544fd8ac5dfa3dc41ea3b6","type":"table_of_contents_item","conversion_output":true,"parent_id":"c62d021d59254925b519ae426922678f","text":"and Reporting of Osteoarthritis of the Knee","text_display":" and Reporting of Osteoarthritis of the Knee","confidence":1,"confidence_rate":1},{"cnt":[[1689,1620],[1753,1620],[1753,1659],[1689,1659]],"region":{"top_left_x":1688,"top_left_y":1619,"width":66,"height":40},"line":64,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50ca9feac7fa4ea5ac410f486155cba8","type":"table_of_contents_number","conversion_output":true,"parent_id":"c62d021d59254925b519ae426922678f","text":"104","text_display":" ..... 104","confidence":1,"confidence_rate":1},{"cnt":[[241,1680],[1755,1680],[1755,1734],[241,1734]],"region":{"top_left_x":240,"top_left_y":1680,"width":1516,"height":54},"line":65,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8695af532ea649ce8902b37934adf638","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["ccd3b1e7294140bfaa0db61203576989","b4dadfa7dfbb480cabcbe98da6a05a2e"],"text":"","text_display":""},{"cnt":[[245,1684],[1072,1684],[1072,1729],[245,1729]],"region":{"top_left_x":244,"top_left_y":1684,"width":829,"height":46},"line":66,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccd3b1e7294140bfaa0db61203576989","type":"table_of_contents_item","conversion_output":true,"parent_id":"8695af532ea649ce8902b37934adf638","text":"Appendix B: Safety Laboratory Parameters","text_display":"\nAppendix B: Safety Laboratory Parameters","confidence":0.99951171875,"confidence_rate":0.9999891467144949},{"cnt":[[1689,1684],[1753,1684],[1753,1727],[1689,1727]],"region":{"top_left_x":1688,"top_left_y":1684,"width":66,"height":44},"line":67,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4dadfa7dfbb480cabcbe98da6a05a2e","type":"table_of_contents_number","conversion_output":true,"parent_id":"8695af532ea649ce8902b37934adf638","text":"105","text_display":" ..... 105","confidence":1,"confidence_rate":1},{"cnt":[[241,1749],[1755,1749],[1755,1807],[241,1807]],"region":{"top_left_x":240,"top_left_y":1748,"width":1516,"height":59},"line":68,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d218586c20de4604926d0eb38626ccc6","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["be06fc33b95d47f4814bfd6e8a74d563","af94cc26d3464e9f9796c6e8b37d4d7e"],"text":"","text_display":""},{"cnt":[[245,1753],[1590,1753],[1590,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1753,"width":1346,"height":46},"line":69,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be06fc33b95d47f4814bfd6e8a74d563","type":"table_of_contents_item","conversion_output":true,"parent_id":"d218586c20de4604926d0eb38626ccc6","text":"Appendix C: Subject Questionnaires: WOMAC, MOS SF-36, and ICOAP","text_display":"\nAppendix C: Subject Questionnaires: WOMAC, MOS SF-36, and ICOAP","confidence":1,"confidence_rate":1},{"cnt":[[1689,1753],[1753,1753],[1753,1796],[1689,1796]],"region":{"top_left_x":1688,"top_left_y":1753,"width":66,"height":44},"line":70,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af94cc26d3464e9f9796c6e8b37d4d7e","type":"table_of_contents_number","conversion_output":true,"parent_id":"d218586c20de4604926d0eb38626ccc6","text":"106","text_display":" ..... 106","confidence":1,"confidence_rate":1},{"cnt":[[243,1818],[1755,1818],[1755,1921],[243,1921]],"region":{"top_left_x":242,"top_left_y":1817,"width":1514,"height":104},"line":71,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2175fb19873d4babac9f9063c8e0ff30","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["ff679ad9da124ebf929f8c8420e9e882","fb985b62bd4548e1a8c28df91ee80e65","dd1f294da4c44c58be4009b46c9e41cc"],"text":"","text_display":""},{"cnt":[[245,1822],[1618,1822],[1618,1869],[245,1869]],"region":{"top_left_x":244,"top_left_y":1821,"width":1374,"height":49},"line":72,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff679ad9da124ebf929f8c8420e9e882","type":"table_of_contents_item","conversion_output":true,"parent_id":"2175fb19873d4babac9f9063c8e0ff30","text":"Appendix D: Knee Injury and Osteoarthritis Outcome Score Quality of Life","text_display":"\nAppendix D: Knee Injury and Osteoarthritis Outcome Score Quality of Life","confidence":0.9970703125,"confidence_rate":0.9999618969930187},{"cnt":[[571,1869],[1336,1869],[1336,1919],[571,1919]],"region":{"top_left_x":571,"top_left_y":1869,"width":766,"height":50},"line":73,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb985b62bd4548e1a8c28df91ee80e65","type":"table_of_contents_item","conversion_output":true,"parent_id":"2175fb19873d4babac9f9063c8e0ff30","text":"(KOOS QOL) and Symptom Index Subscales","text_display":" (KOOS QOL) and Symptom Index Subscales","confidence":1,"confidence_rate":1},{"cnt":[[1689,1867],[1753,1867],[1753,1919],[1689,1919]],"region":{"top_left_x":1688,"top_left_y":1866,"width":66,"height":53},"line":74,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd1f294da4c44c58be4009b46c9e41cc","type":"table_of_contents_number","conversion_output":true,"parent_id":"2175fb19873d4babac9f9063c8e0ff30","text":"107","text_display":" ..... 107","confidence":1,"confidence_rate":1},{"cnt":[[243,1934],[1755,1934],[1755,1989],[243,1989]],"region":{"top_left_x":242,"top_left_y":1933,"width":1514,"height":57},"line":75,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8abcfdb8213449dacb5347c6f94ca0b","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["771f02e4883f4faab161624bf8961763","295aabb69d4e46619fa79c2e8c4dcf7f"],"text":"","text_display":""},{"cnt":[[245,1938],[1061,1938],[1061,1985],[245,1985]],"region":{"top_left_x":244,"top_left_y":1937,"width":818,"height":49},"line":76,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"771f02e4883f4faab161624bf8961763","type":"table_of_contents_item","conversion_output":true,"parent_id":"c8abcfdb8213449dacb5347c6f94ca0b","text":"Appendix E: Schedule of Trial Procedures","text_display":"\nAppendix E: Schedule of Trial Procedures","confidence":0.99951171875,"confidence_rate":0.9999891467144949},{"cnt":[[1689,1936],[1753,1936],[1753,1987],[1689,1987]],"region":{"top_left_x":1688,"top_left_y":1935,"width":66,"height":53},"line":77,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"295aabb69d4e46619fa79c2e8c4dcf7f","type":"table_of_contents_number","conversion_output":true,"parent_id":"c8abcfdb8213449dacb5347c6f94ca0b","text":"109","text_display":" ..... 109","confidence":1,"confidence_rate":1},{"cnt":[[243,2002],[1755,2002],[1755,2060],[243,2060]],"region":{"top_left_x":242,"top_left_y":2002,"width":1514,"height":59},"line":78,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"beb47821626e47cfa2601a85237434f7","type":"table_of_contents_row","conversion_output":false,"parent_id":"f66dc8df742c43889208e087ea26a734","children_ids":["a2d41e9244ca476cad5aba3b47d47de7","7566e898bfdc44bf8b39f44ac43a1579"],"text":"","text_display":""},{"cnt":[[245,2007],[904,2007],[904,2054],[245,2054]],"region":{"top_left_x":244,"top_left_y":2006,"width":661,"height":48},"line":79,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2d41e9244ca476cad5aba3b47d47de7","type":"table_of_contents_item","conversion_output":true,"parent_id":"beb47821626e47cfa2601a85237434f7","text":"Appendix F: Pain in Other Joints","text_display":"\nAppendix F: Pain in Other Joints","confidence":1,"confidence_rate":1},{"cnt":[[1689,2004],[1753,2004],[1753,2056],[1689,2056]],"region":{"top_left_x":1688,"top_left_y":2004,"width":66,"height":53},"line":80,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7566e898bfdc44bf8b39f44ac43a1579","type":"table_of_contents_number","conversion_output":true,"parent_id":"beb47821626e47cfa2601a85237434f7","text":"113","text_display":" ..... 113","confidence":1,"confidence_rate":1},{"cnt":[[245,2512],[434,2512],[434,2542],[245,2542]],"region":{"top_left_x":244,"top_left_y":2511,"width":190,"height":31},"line":81,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"deadd2cf0f5e4c53aebbe6cc75a0620b","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[447,2512],[507,2512],[507,2548],[447,2548]],"region":{"top_left_x":446,"top_left_y":2511,"width":62,"height":38},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"532fbd0569fd47de8f5caeb1241276c7","type":"page_info","conversion_output":false,"text":"CCI","text_display":"","confidence":0.9985356330871582,"confidence_rate":0.9998168367581932},{"cnt":[[245,2548],[387,2548],[387,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":143,"height":37},"line":83,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"df4229da5104425caf40cef02100a357","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99853515625,"confidence_rate":0.9999022769297106},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c982c46339e4edf85a131116d67f91f","type":"page_info","conversion_output":false,"text":"10/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1897,2501],[1897,2597],[1796,2597]],"region":{"top_left_x":1796,"top_left_y":2500,"width":102,"height":98},"line":85,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6a6548a4171e413c8dbbe781333dcc4d","type":"page_info","conversion_output":false,"text":"\\(\\sqrt{A} \\sqrt{L}\\)","text_display":"","confidence":0.13944068047788588,"confidence_rate":0.8485923737269772}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-011","page":11,"lines":[{"cnt":[[245,129],[434,129],[434,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":190,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5f75c6c1a5741a38c0fb3c2785f7ee3","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,127],[1317,127],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":126,"width":673,"height":49},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b463e189c6a45fdb9320af31a825efa","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d63a0761287441d28b9ea2e203f085ac","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,322],[578,322],[578,376],[243,376]],"region":{"top_left_x":242,"top_left_y":322,"width":336,"height":54},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b757ed1af0db449fb69058745a085f60","type":"section_header","conversion_output":false,"children_ids":["dec19edfae1f4ea1bc7bc32e0b5a336e"],"text":"","text_display":""},{"cnt":[[245,327],[574,327],[574,372],[245,372]],"region":{"top_left_x":244,"top_left_y":326,"width":330,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dec19edfae1f4ea1bc7bc32e0b5a336e","type":"text","conversion_output":true,"parent_id":"b757ed1af0db449fb69058745a085f60","text":"Table of Tables","text_display":"\n\n\\section*{Table of Tables}","confidence":1,"confidence_rate":1},{"cnt":[[245,397],[1755,397],[1755,453],[245,453]],"region":{"top_left_x":244,"top_left_y":397,"width":1512,"height":57},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44ecbafa2da3499f9fa0e707d29fce5d","type":"text","conversion_output":true,"text":"Table 1 Drug Administration Diagram........................................................ 47","text_display":"\n\nTable 1 Drug Administration Diagram........................................................ 47","confidence":0.8496186209173788,"confidence_rate":0.9983877593609262},{"cnt":[[245,466],[1755,466],[1755,520],[245,520]],"region":{"top_left_x":244,"top_left_y":466,"width":1512,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7188dd202dda4c60a5dc8c636ee7da46","type":"text","conversion_output":true,"text":"Table 2 Trial Visits during DBPC Treatment Phase..................................... 60","text_display":"\nTable 2 Trial Visits during DBPC Treatment Phase..................................... 60","confidence":0.9863907164787888,"confidence_rate":0.9998557710473204},{"cnt":[[245,535],[1652,535],[1652,587],[245,587]],"region":{"top_left_x":244,"top_left_y":534,"width":1409,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d241eb5b985d491caa76c36d29880249","type":"text","conversion_output":true,"text":"Table 3 Power Calculations for Pairwise Differences (Sprifermin versus","text_display":"\nTable 3 Power Calculations for Pairwise Differences (Sprifermin versus","confidence":0.9980475902557373,"confidence_rate":0.9999749449525931},{"cnt":[[569,584],[1596,584],[1596,634],[569,634]],"region":{"top_left_x":569,"top_left_y":584,"width":1028,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f2038037a4a42418828f073ba5f858b","type":"text","conversion_output":true,"text":"Placebo) on Normalized WOMAC Scores with 76 Evaluable","text_display":" Placebo) on Normalized WOMAC Scores with 76 Evaluable","confidence":1,"confidence_rate":1},{"cnt":[[571,632],[1755,632],[1755,685],[571,685]],"region":{"top_left_x":571,"top_left_y":631,"width":1185,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1317fb60f10543e7bc9e2e47d037c3c3","type":"text","conversion_output":true,"text":"Subjects per Treatment Group ......................................................... 86","text_display":" Subjects per Treatment Group ......................................................... 86","confidence":0.8577839790864108,"confidence_rate":0.9983518652185928},{"cnt":[[245,700],[1687,700],[1687,752],[245,752]],"region":{"top_left_x":244,"top_left_y":700,"width":1443,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba517f5382074369b697b2a69d993a71","type":"text","conversion_output":true,"text":"Table 4 Summary of Criteria for Classification of Idiopathic Osteoarthritis","text_display":"\nTable 4 Summary of Criteria for Classification of Idiopathic Osteoarthritis","confidence":1,"confidence_rate":1},{"cnt":[[571,750],[1755,750],[1755,793],[571,793]],"region":{"top_left_x":571,"top_left_y":749,"width":1185,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3d45590879d41f8b7809a87754f4f11","type":"text","conversion_output":true,"text":"of the Knee.......................................................................................... 104","text_display":" of the Knee.......................................................................................... 104","confidence":0.06106408495670506,"confidence_rate":0.9746763329566834},{"cnt":[[245,816],[1755,816],[1755,862],[245,862]],"region":{"top_left_x":244,"top_left_y":816,"width":1512,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fe68354683f42d7a2a41ad98c69aca1","type":"text","conversion_output":true,"text":"Table 5 Schedule of Trial Procedures for Visits 1 to 11.............................. 109","text_display":"\n\nTable 5 Schedule of Trial Procedures for Visits 1 to 11.............................. 109","confidence":0.6820983717916533,"confidence_rate":0.996142998911614},{"cnt":[[245,885],[1620,885],[1620,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1376,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d66dbcfc89884974ae6167ae7f54c8c7","type":"text","conversion_output":true,"text":"Table 6 Schedule of Trial Procedures for Visits 12 to 22 and Extended","text_display":"\nTable 6 Schedule of Trial Procedures for Visits 12 to 22 and Extended","confidence":1,"confidence_rate":1},{"cnt":[[571,935],[1755,935],[1755,986],[571,986]],"region":{"top_left_x":571,"top_left_y":934,"width":1185,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2859b8850d89494eb12bfc5317326477","type":"text","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-011.jpg?height=53&width=1185&top_left_y=934&top_left_x=571)"},{"cnt":[[245,1113],[595,1113],[595,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1112,"width":352,"height":64},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c30ce03471cb428483bac9d8f0f8700c","type":"section_header","conversion_output":false,"children_ids":["765ed60c3aea40329e969f6efffc4a85"],"text":"","text_display":""},{"cnt":[[247,1117],[595,1117],[595,1171],[247,1171]],"region":{"top_left_x":247,"top_left_y":1117,"width":349,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"765ed60c3aea40329e969f6efffc4a85","type":"text","conversion_output":true,"parent_id":"c30ce03471cb428483bac9d8f0f8700c","text":"Table of Figures","text_display":"\n\n\\section*{Table of Figures}","confidence":1,"confidence_rate":1},{"cnt":[[245,1190],[1755,1190],[1755,1242],[245,1242]],"region":{"top_left_x":244,"top_left_y":1190,"width":1512,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9f25e896add4dd399cde092cda7b827","type":"text","conversion_output":true,"text":"Figure 1 Trial Schema: Screening and DBPC Treatment Phases .................... 32","text_display":"\n\nFigure 1 Trial Schema: Screening and DBPC Treatment Phases .................... 32","confidence":0.94677734375,"confidence_rate":0.9993856794360495},{"cnt":[[245,1259],[1755,1259],[1755,1311],[245,1311]],"region":{"top_left_x":244,"top_left_y":1258,"width":1512,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73a952f4f8c140da8b6e75268f52382b","type":"text","conversion_output":true,"text":"Figure 2 Trial Schema: Extended Follow-up Phase....................................... 33","text_display":"\nFigure 2 Trial Schema: Extended Follow-up Phase....................................... 33","confidence":0.9699945332226889,"confidence_rate":0.9996827082294185},{"cnt":[[245,1328],[1626,1328],[1626,1379],[245,1379]],"region":{"top_left_x":244,"top_left_y":1327,"width":1383,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86ab2cb62db449a5ab90923f227a18cb","type":"text","conversion_output":true,"text":"Figure 3 Expected Mean Changes in Cartilage Thickness (mm) in Total","text_display":"\nFigure 3 Expected Mean Changes in Cartilage Thickness (mm) in Total","confidence":0.5443898546509445,"confidence_rate":0.9919249181377282},{"cnt":[[569,1377],[1755,1377],[1755,1429],[569,1429]],"region":{"top_left_x":569,"top_left_y":1377,"width":1187,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62dd0d6cb3d64dfc8ad01c2aa86b4239","type":"text","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-011.jpg?height=52&width=1187&top_left_y=1377&top_left_x=569)"},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f9f8e14fd714afaa391703ce8b4a035","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[440,2509],[509,2509],[509,2548],[440,2548]],"region":{"top_left_x":440,"top_left_y":2509,"width":70,"height":40},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1e02a44f4c54219b63565804a40a209","type":"page_info","conversion_output":false,"text":"CCI","text_display":"","confidence":0.9689881801605225,"confidence_rate":0.9960698850533571},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e162eb1a2a194b139ebf071ab137875a","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"348a95f36c7240dc98257b33cef44a5c","type":"page_info","conversion_output":false,"text":"11/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1800,2509],[1886,2509],[1886,2597],[1800,2597]],"region":{"top_left_x":1800,"top_left_y":2509,"width":87,"height":89},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4b61cf1af634b5d80f14afd485652a6","type":"page_info","conversion_output":false,"text":"\\(9 \\sqrt{1}\\)","text_display":"","confidence":0.757893368601799,"confidence_rate":0.9611721047241687}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-012","page":12,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d853c02638574f26b1bd9a3448ae9878","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[640,125],[1317,125],[1317,174],[640,174]],"region":{"top_left_x":640,"top_left_y":124,"width":677,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"edfb1a14aa1f41eeadc40f843438da0d","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90ad8634ce41459788cdcebb4129ef6e","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,316],[703,316],[703,380],[236,380]],"region":{"top_left_x":236,"top_left_y":315,"width":467,"height":66},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da5c3315b3314d028ea3ff416f2fc333","type":"section_header","conversion_output":false,"children_ids":["0a0f1797a3fa4d17af5611c581f5c328"],"text":"","text_display":""},{"cnt":[[243,322],[694,322],[694,376],[243,376]],"region":{"top_left_x":242,"top_left_y":322,"width":452,"height":54},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a0f1797a3fa4d17af5611c581f5c328","type":"text","conversion_output":true,"parent_id":"da5c3315b3314d028ea3ff416f2fc333","text":"List of Abbreviations","text_display":"\n\n\\section*{List of Abbreviations}","confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[258,417],[1448,417],[1448,2445],[258,2445]],"region":{"top_left_x":257,"top_left_y":416,"width":1192,"height":2029},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a4bdea5709f49f3a40454b065de43cb","type":"table","conversion_output":true,"children_ids":["7864e4d5397c44d3af4e36aa96a2b4df","4ab28a8dddde4b089359656b4e51a58c","14a7b50f5f3b41bba35bca33db43655c","611fd78300224cc89a54a27bea67eb53","ea1d79c093b64dcbba76f6f9660c1b63","cc62248e410f4cbcb68f65a0554a0699","682ec6ed0c534deda8ce2b7ca6a18269","d57b7ecda22d4f6e8422f71c34a9972a","61feb363e6ba42859ce7e51ee0b847c1","b4dbe610734f4cc68057758cd5290e6f","e5607337d046428694ecac7eefba97fc","a09d27887bd84727ac989cdfff60fcc5","8bffa9db3ffe44c9b4c941483a1e3666","e0d88002385d4df58c05cec27c699d15","4b4306b871f34639b3f8c93e27bc8909","aeed412e47f342c18b7c589912810a31","c6f77f8760ad41fc969872ee51481a91","919de7a7b40f4aaca917ec05e998c5eb","6222820f8ddb4de99e492eea1791e277","0f62b966988e4ed8bc7195ade9b8343c","0de0dc1c6e36471bad05e316b0f24087","ccf8c1eb021b4b4d93f6bac2f00c23cd","794466fb75024e098771581c94b1dfc1","d493601f794749de9e26ecae4604a3e4","00ff8c66e3bb44b5ada8ddc5df2acdf8","6c6f0d0f0da049a9b37b3dd48b87c89d","23c9ecf16f5e4ff58af89886c674ba68","01b28c0dcb1e4fedb5576ab134f0330d","a396bd13431743f5862ec5f2b7bae469","107dd3e57d8a4391adbe1b9004125606","67cd32da6cd9415db61b9fd162fde352","5934c876ea7a4cb081ed871da3067aa2","361a6a7dfd2b413cbe39448123944595","687d11eca0ff460384d501d2999f5e70","b160695a3e064cb1a26628b20a260d69","0033d8ff504b44a181e290b95b4c1948","5823d041901844f9a4b08ca9dc3868c7","86f2b9f3c0ea42909703a5688b55e398","04a9bc52b1e94299bc43554a9d8f9858","4de1a67bf7c749a293059e42a13fee28","b802f65ce2ec431eb7d166d23bdcd985","c47ebb1a869b424583331e328b617208","df3aeccc9a6a4855abfac942d66a9d57","a8c6cee6713a46f995d0113ef36638d5","e3230e400c3e4c60b2f89f9297945c57","657a6d759c3d4811801f52a6e0b85876","f55fa29e441d466c898868a2d9b9b895","1be777e9bcb94e93ae34f8c15324b814","61dd4759b1a64c58b2ecb88651eeac03","e19a21af3f954d7abb5eb404f4ac5a55","0e6c3d3e6b44430eba412b874a19e759","e8b8bdbf2abe4bfe912811c578df1ccc","88900d9d16d9431d9325b383b46e468a","66b3351016134390a2e29a4e7f93afdd","745ca0dc5e56475894017212473d5977","d7e7325b01084a21923db6e105fd8380","2106dd15acb94be58b93415f36ba8161","17124af0bc6a48adaa9acc0762119b94","6490ac06284943a7be07d0bf4db7cfb8","d3120540314a4822b1c4f20df3484ad6","6a3e96034d094b92a7b2f68908ca98f7","c23bff2a855c45c7ac5bd8b3426d632b","f02e94ea0c6f476b8b52366468b1fcf2","4746f67bcf0d4607b01521dd4b1243d4","353d2d8a3a5c437ba123813a37ccfb59","300ea9150f424ec98bbe1b450a92df34","cebbefdcd7e343e28888972c9f2a697a","cf7fac88bcba44f19f45a567749caf1f","e74bbf3b3c954fa5868714df11653f96","9e8a1b2370214a20ac8aae9e210d31db","1341cf07b876479885d9e846b3e4354c"],"text":"\\begin{tabular}{|l|l|}\n\\hline AE & Adverse event \\\\\n\\hline AIR & Acute inflammatory reaction \\\\\n\\hline ALP & Alkaline phosphatase \\\\\n\\hline ALT & Alanine aminotransferase \\\\\n\\hline ANOVA & Analysis of variance \\\\\n\\hline AST & Aspartate aminotransferase \\\\\n\\hline BLOKS & Boston-Leeds Osteoarthritis Knee Score \\\\\n\\hline BUN & Blood urea nitrogen \\\\\n\\hline CFR & (United States) Code of Federal Regulations \\\\\n\\hline CI & Confidence interval \\\\\n\\hline CK & Creatine kinase \\\\\n\\hline COMP & Cartilage oligomeric matrix protein \\\\\n\\hline coxib & COX-2 selective inhibitor \\\\\n\\hline CRF & Case Report Form \\\\\n\\hline CS846 & Chondroitin sulfate epitope 846 \\\\\n\\hline CTX-II & C-telopeptide cross-linking of type II collagen \\\\\n\\hline DBPC & Double-blind placebo-controlled \\\\\n\\hline DMPK & Drug Metabolism and Pharmacokinetics \\\\\n\\hline ECG & Electrocardiogram \\\\\n\\hline EEA & European Economic Area \\\\\n\\hline EF & Extended follow-up \\\\\n\\hline EMA & European Medicines Agency \\\\\n\\hline ESR & Erythrocyte sedimentation rate \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline AE & Adverse event \\\\\n\\hline AIR & Acute inflammatory reaction \\\\\n\\hline ALP & Alkaline phosphatase \\\\\n\\hline ALT & Alanine aminotransferase \\\\\n\\hline ANOVA & Analysis of variance \\\\\n\\hline AST & Aspartate aminotransferase \\\\\n\\hline BLOKS & Boston-Leeds Osteoarthritis Knee Score \\\\\n\\hline BUN & Blood urea nitrogen \\\\\n\\hline CFR & (United States) Code of Federal Regulations \\\\\n\\hline CI & Confidence interval \\\\\n\\hline CK & Creatine kinase \\\\\n\\hline COMP & Cartilage oligomeric matrix protein \\\\\n\\hline coxib & COX-2 selective inhibitor \\\\\n\\hline CRF & Case Report Form \\\\\n\\hline CS846 & Chondroitin sulfate epitope 846 \\\\\n\\hline CTX-II & C-telopeptide cross-linking of type II collagen \\\\\n\\hline DBPC & Double-blind placebo-controlled \\\\\n\\hline DMPK & Drug Metabolism and Pharmacokinetics \\\\\n\\hline ECG & Electrocardiogram \\\\\n\\hline EEA & European Economic Area \\\\\n\\hline EF & Extended follow-up \\\\\n\\hline EMA & European Medicines Agency \\\\\n\\hline ESR & Erythrocyte sedimentation rate \\\\\n\\hline\n\\end{tabular}","confidence":0.99951171875,"confidence_rate":0.9999997788041467},{"cnt":[[257,416],[425,416],[429,2445],[261,2445]],"region":{"top_left_x":256,"top_left_y":415,"width":174,"height":2031},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7864e4d5397c44d3af4e36aa96a2b4df","type":"table_column","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[655,2445],[658,415],[1444,416],[1442,2446]],"region":{"top_left_x":655,"top_left_y":415,"width":790,"height":2031},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ab28a8dddde4b089359656b4e51a58c","type":"table_column","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,420],[1446,420],[1446,464],[257,464]],"region":{"top_left_x":257,"top_left_y":420,"width":1189,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14a7b50f5f3b41bba35bca33db43655c","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,509],[1446,509],[1446,561],[257,561]],"region":{"top_left_x":257,"top_left_y":509,"width":1189,"height":53},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"611fd78300224cc89a54a27bea67eb53","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,600],[1446,600],[1446,652],[257,652]],"region":{"top_left_x":257,"top_left_y":600,"width":1189,"height":53},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea1d79c093b64dcbba76f6f9660c1b63","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,689],[1446,689],[1446,734],[257,734]],"region":{"top_left_x":257,"top_left_y":688,"width":1189,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc62248e410f4cbcb68f65a0554a0699","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,775],[1446,775],[1446,830],[257,830]],"region":{"top_left_x":257,"top_left_y":775,"width":1189,"height":55},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"682ec6ed0c534deda8ce2b7ca6a18269","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,866],[1446,866],[1446,916],[257,916]],"region":{"top_left_x":257,"top_left_y":866,"width":1189,"height":51},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d57b7ecda22d4f6e8422f71c34a9972a","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,957],[1446,957],[1446,1003],[257,1003]],"region":{"top_left_x":257,"top_left_y":957,"width":1189,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61feb363e6ba42859ce7e51ee0b847c1","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1044],[1446,1044],[1446,1096],[257,1096]],"region":{"top_left_x":257,"top_left_y":1043,"width":1189,"height":53},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4dbe610734f4cc68057758cd5290e6f","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1135],[1446,1135],[1446,1187],[257,1187]],"region":{"top_left_x":257,"top_left_y":1134,"width":1189,"height":53},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5607337d046428694ecac7eefba97fc","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1226],[1446,1226],[1446,1271],[257,1271]],"region":{"top_left_x":257,"top_left_y":1225,"width":1189,"height":47},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a09d27887bd84727ac989cdfff60fcc5","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1313],[1446,1313],[1446,1360],[257,1360]],"region":{"top_left_x":257,"top_left_y":1312,"width":1189,"height":49},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bffa9db3ffe44c9b4c941483a1e3666","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1403],[1446,1403],[1446,1458],[257,1458]],"region":{"top_left_x":257,"top_left_y":1403,"width":1189,"height":55},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0d88002385d4df58c05cec27c699d15","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1494],[1446,1494],[1446,1540],[257,1540]],"region":{"top_left_x":257,"top_left_y":1494,"width":1189,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b4306b871f34639b3f8c93e27bc8909","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1583],[1446,1583],[1446,1635],[257,1635]],"region":{"top_left_x":257,"top_left_y":1583,"width":1189,"height":53},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aeed412e47f342c18b7c589912810a31","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1672],[1446,1672],[1446,1726],[257,1726]],"region":{"top_left_x":257,"top_left_y":1671,"width":1189,"height":56},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6f77f8760ad41fc969872ee51481a91","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1761],[1446,1761],[1446,1815],[257,1815]],"region":{"top_left_x":257,"top_left_y":1760,"width":1189,"height":55},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"919de7a7b40f4aaca917ec05e998c5eb","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1850],[1446,1850],[1446,1904],[257,1904]],"region":{"top_left_x":257,"top_left_y":1849,"width":1189,"height":55},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6222820f8ddb4de99e492eea1791e277","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,1941],[1446,1941],[1446,1995],[257,1995]],"region":{"top_left_x":257,"top_left_y":1940,"width":1189,"height":55},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f62b966988e4ed8bc7195ade9b8343c","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,2031],[1446,2031],[1446,2083],[257,2083]],"region":{"top_left_x":257,"top_left_y":2031,"width":1189,"height":53},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0de0dc1c6e36471bad05e316b0f24087","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,2120],[1446,2120],[1446,2172],[257,2172]],"region":{"top_left_x":257,"top_left_y":2120,"width":1189,"height":53},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccf8c1eb021b4b4d93f6bac2f00c23cd","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,2209],[1446,2209],[1446,2263],[257,2263]],"region":{"top_left_x":257,"top_left_y":2209,"width":1189,"height":55},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"794466fb75024e098771581c94b1dfc1","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,2300],[1446,2300],[1446,2352],[257,2352]],"region":{"top_left_x":257,"top_left_y":2299,"width":1189,"height":53},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d493601f794749de9e26ecae4604a3e4","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,2387],[1446,2387],[1446,2441],[257,2441]],"region":{"top_left_x":257,"top_left_y":2386,"width":1189,"height":55},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00ff8c66e3bb44b5ada8ddc5df2acdf8","type":"table_row","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"","text_display":""},{"cnt":[[257,416],[326,416],[326,459],[257,459]],"region":{"top_left_x":257,"top_left_y":416,"width":70,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c6f0d0f0da049a9b37b3dd48b87c89d","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"AE","text_display":"AE","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,425],[907,425],[907,461],[662,461]],"region":{"top_left_x":661,"top_left_y":424,"width":246,"height":38},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23c9ecf16f5e4ff58af89886c674ba68","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Adverse event","text_display":"Adverse event","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,511],[348,511],[348,550],[266,550]],"region":{"top_left_x":265,"top_left_y":511,"width":83,"height":40},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01b28c0dcb1e4fedb5576ab134f0330d","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"AIR","text_display":"AIR","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,511],[1151,511],[1151,557],[660,557]],"region":{"top_left_x":659,"top_left_y":511,"width":493,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a396bd13431743f5862ec5f2b7bae469","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Acute inflammatory reaction","text_display":"Acute inflammatory reaction","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,602],[350,602],[350,639],[266,639]],"region":{"top_left_x":265,"top_left_y":602,"width":86,"height":38},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"107dd3e57d8a4391adbe1b9004125606","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"ALP","text_display":"ALP","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,602],[1026,602],[1026,648],[660,648]],"region":{"top_left_x":659,"top_left_y":602,"width":367,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67cd32da6cd9415db61b9fd162fde352","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Alkaline phosphatase","text_display":"Alkaline phosphatase","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,693],[350,693],[350,730],[266,730]],"region":{"top_left_x":265,"top_left_y":693,"width":86,"height":37},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5934c876ea7a4cb081ed871da3067aa2","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"ALT","text_display":"ALT","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,693],[1095,693],[1095,730],[660,730]],"region":{"top_left_x":659,"top_left_y":693,"width":437,"height":37},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"361a6a7dfd2b413cbe39448123944595","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Alanine aminotransferase","text_display":"Alanine aminotransferase","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[265,782],[424,779],[424,819],[266,822]],"region":{"top_left_x":264,"top_left_y":778,"width":161,"height":45},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"687d11eca0ff460384d501d2999f5e70","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"ANOVA","text_display":"ANOVA","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,780],[1008,780],[1008,825],[660,825]],"region":{"top_left_x":659,"top_left_y":779,"width":350,"height":47},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b160695a3e064cb1a26628b20a260d69","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Analysis of variance","text_display":"Analysis of variance","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,871],[350,871],[350,908],[266,908]],"region":{"top_left_x":265,"top_left_y":870,"width":86,"height":38},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0033d8ff504b44a181e290b95b4c1948","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"AST","text_display":"AST","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,871],[1125,871],[1125,916],[660,916]],"region":{"top_left_x":659,"top_left_y":870,"width":467,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5823d041901844f9a4b08ca9dc3868c7","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Aspartate aminotransferase","text_display":"Aspartate aminotransferase","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,960],[406,960],[406,999],[266,999]],"region":{"top_left_x":265,"top_left_y":959,"width":142,"height":40},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86f2b9f3c0ea42909703a5688b55e398","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"BLOKS","text_display":"BLOKS","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,960],[1340,960],[1340,999],[660,999]],"region":{"top_left_x":659,"top_left_y":959,"width":681,"height":40},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04a9bc52b1e94299bc43554a9d8f9858","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Boston-Leeds Osteoarthritis Knee Score","text_display":"Boston-Leeds Osteoarthritis Knee Score","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,1048],[359,1048],[359,1085],[266,1085]],"region":{"top_left_x":265,"top_left_y":1048,"width":94,"height":38},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4de1a67bf7c749a293059e42a13fee28","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"BUN","text_display":"BUN","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1048],[1004,1048],[1004,1094],[660,1094]],"region":{"top_left_x":659,"top_left_y":1048,"width":346,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b802f65ce2ec431eb7d166d23bdcd985","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Blood urea nitrogen","text_display":"Blood urea nitrogen","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,1139],[350,1139],[350,1176],[266,1176]],"region":{"top_left_x":265,"top_left_y":1139,"width":86,"height":38},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c47ebb1a869b424583331e328b617208","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"CFR","text_display":"CFR","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1139],[1407,1139],[1407,1185],[660,1185]],"region":{"top_left_x":659,"top_left_y":1139,"width":748,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df3aeccc9a6a4855abfac942d66a9d57","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"(United States) Code of Federal Regulations","text_display":"(United States) Code of Federal Regulations","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.999989825041388},{"cnt":[[257,1219],[318,1219],[318,1271],[257,1271]],"region":{"top_left_x":257,"top_left_y":1219,"width":61,"height":53},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8c6cee6713a46f995d0113ef36638d5","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"CI","text_display":"CI","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1226],[995,1226],[995,1267],[660,1267]],"region":{"top_left_x":659,"top_left_y":1225,"width":337,"height":43},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3230e400c3e4c60b2f89f9297945c57","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Confidence interval","text_display":"Confidence interval","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[257,1317],[333,1317],[333,1360],[257,1360]],"region":{"top_left_x":257,"top_left_y":1316,"width":76,"height":45},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"657a6d759c3d4811801f52a6e0b85876","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"CK","text_display":"CK","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1317],[926,1317],[926,1358],[660,1358]],"region":{"top_left_x":659,"top_left_y":1316,"width":268,"height":42},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f55fa29e441d466c898868a2d9b9b895","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Creatine kinase","text_display":"Creatine kinase","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,1408],[389,1408],[389,1445],[266,1445]],"region":{"top_left_x":265,"top_left_y":1407,"width":125,"height":38},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1be777e9bcb94e93ae34f8c15324b814","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"COMP","text_display":"COMP","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1408],[1260,1408],[1260,1453],[660,1453]],"region":{"top_left_x":659,"top_left_y":1407,"width":601,"height":47},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61dd4759b1a64c58b2ecb88651eeac03","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Cartilage oligomeric matrix protein","text_display":"Cartilage oligomeric matrix protein","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,1494],[363,1494],[363,1536],[266,1536]],"region":{"top_left_x":265,"top_left_y":1494,"width":99,"height":42},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e19a21af3f954d7abb5eb404f4ac5a55","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"coxib","text_display":"coxib","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1494],[1102,1494],[1102,1536],[660,1536]],"region":{"top_left_x":659,"top_left_y":1494,"width":443,"height":42},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e6c3d3e6b44430eba412b874a19e759","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"COX-2 selective inhibitor","text_display":"COX-2 selective inhibitor","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,1585],[350,1585],[350,1627],[266,1627]],"region":{"top_left_x":265,"top_left_y":1585,"width":86,"height":42},"line":58,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8b8bdbf2abe4bfe912811c578df1ccc","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"CRF","text_display":"CRF","cell_row":13,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1585],[974,1585],[974,1633],[660,1633]],"region":{"top_left_x":659,"top_left_y":1585,"width":315,"height":49},"line":59,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88900d9d16d9431d9325b383b46e468a","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Case Report Form","text_display":"Case Report Form","cell_row":13,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,1676],[385,1676],[385,1717],[266,1717]],"region":{"top_left_x":265,"top_left_y":1676,"width":120,"height":42},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66b3351016134390a2e29a4e7f93afdd","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"CS846","text_display":"CS846","cell_row":14,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1676],[1199,1676],[1199,1722],[660,1722]],"region":{"top_left_x":659,"top_left_y":1676,"width":540,"height":46},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"745ca0dc5e56475894017212473d5977","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Chondroitin sulfate epitope 846","text_display":"Chondroitin sulfate epitope 846","cell_row":14,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,1763],[398,1763],[398,1804],[266,1804]],"region":{"top_left_x":265,"top_left_y":1762,"width":133,"height":43},"line":62,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7e7325b01084a21923db6e105fd8380","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"CTX-II","text_display":"CTX-II","cell_row":15,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1763],[1439,1763],[1439,1813],[660,1813]],"region":{"top_left_x":659,"top_left_y":1762,"width":781,"height":51},"line":63,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2106dd15acb94be58b93415f36ba8161","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"C-telopeptide cross-linking of type II collagen","text_display":"C-telopeptide cross-linking of type II collagen","cell_row":15,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,1854],[380,1854],[380,1895],[266,1895]],"region":{"top_left_x":265,"top_left_y":1853,"width":116,"height":43},"line":64,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17124af0bc6a48adaa9acc0762119b94","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"DBPC","text_display":"DBPC","cell_row":16,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1854],[1212,1854],[1212,1904],[660,1904]],"region":{"top_left_x":659,"top_left_y":1853,"width":553,"height":51},"line":65,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6490ac06284943a7be07d0bf4db7cfb8","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Double-blind placebo-controlled","text_display":"Double-blind placebo-controlled","cell_row":16,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,1945],[393,1945],[393,1982],[266,1982]],"region":{"top_left_x":265,"top_left_y":1944,"width":129,"height":38},"line":66,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3120540314a4822b1c4f20df3484ad6","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"DMPK","text_display":"DMPK","cell_row":17,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,1945],[1340,1945],[1340,1990],[660,1990]],"region":{"top_left_x":659,"top_left_y":1944,"width":681,"height":47},"line":67,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a3e96034d094b92a7b2f68908ca98f7","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Drug Metabolism and Pharmacokinetics","text_display":"Drug Metabolism and Pharmacokinetics","cell_row":17,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,2036],[354,2036],[354,2073],[266,2073]],"region":{"top_left_x":265,"top_left_y":2035,"width":90,"height":38},"line":68,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c23bff2a855c45c7ac5bd8b3426d632b","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"ECG","text_display":"ECG","cell_row":18,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,2034],[978,2034],[978,2081],[660,2081]],"region":{"top_left_x":659,"top_left_y":2033,"width":320,"height":49},"line":69,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f02e94ea0c6f476b8b52366468b1fcf2","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Electrocardiogram","text_display":"Electrocardiogram","cell_row":18,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,2122],[354,2122],[354,2159],[266,2159]],"region":{"top_left_x":265,"top_left_y":2122,"width":90,"height":38},"line":70,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4746f67bcf0d4607b01521dd4b1243d4","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"EEA","text_display":"EEA","cell_row":19,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,2122],[1099,2122],[1099,2170],[660,2170]],"region":{"top_left_x":659,"top_left_y":2122,"width":441,"height":49},"line":71,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"353d2d8a3a5c437ba123813a37ccfb59","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"European Economic Area","text_display":"European Economic Area","cell_row":19,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[257,2213],[322,2213],[322,2252],[257,2252]],"region":{"top_left_x":257,"top_left_y":2213,"width":65,"height":40},"line":72,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"300ea9150f424ec98bbe1b450a92df34","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"EF","text_display":"EF","cell_row":20,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,2213],[1000,2213],[1000,2259],[660,2259]],"region":{"top_left_x":659,"top_left_y":2213,"width":341,"height":46},"line":73,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cebbefdcd7e343e28888972c9f2a697a","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Extended follow-up","text_display":"Extended follow-up","cell_row":20,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,2304],[363,2304],[363,2341],[266,2341]],"region":{"top_left_x":265,"top_left_y":2304,"width":99,"height":38},"line":74,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf7fac88bcba44f19f45a567749caf1f","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"EMA","text_display":"EMA","cell_row":21,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,2300],[1151,2300],[1151,2350],[660,2350]],"region":{"top_left_x":659,"top_left_y":2299,"width":493,"height":51},"line":75,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e74bbf3b3c954fa5868714df11653f96","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"European Medicines Agency","text_display":"European Medicines Agency","cell_row":21,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,2393],[350,2393],[350,2432],[266,2432]],"region":{"top_left_x":265,"top_left_y":2393,"width":86,"height":40},"line":76,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e8a1b2370214a20ac8aae9e210d31db","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"ESR","text_display":"ESR","cell_row":22,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[660,2391],[1182,2391],[1182,2439],[660,2439]],"region":{"top_left_x":659,"top_left_y":2390,"width":523,"height":49},"line":77,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1341cf07b876479885d9e846b3e4354c","type":"simple_cell","conversion_output":false,"parent_id":"3a4bdea5709f49f3a40454b065de43cb","text":"Erythrocyte sedimentation rate","text_display":"Erythrocyte sedimentation rate","cell_row":22,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":78,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"17bd78f980104ffd8e9273c7d259068c","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1512,2527],[1601,2527],[1601,2563],[1512,2563]],"region":{"top_left_x":1512,"top_left_y":2526,"width":89,"height":38},"line":79,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6ce32f92c1054428bc96c9962d96b541","type":"page_info","conversion_output":false,"text":"12/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":80,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a67a38f040f248a8b63893b8f39569bc","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-013","page":13,"lines":[{"cnt":[[245,129],[434,129],[434,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":190,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c9d000b4f7d468fbd2b5a5937bb72cb","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c6f898db3a44f35bcb0a6ea4a9894bd","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70c1c83621d64d669d7b1dbe55c4e96c","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[247,316],[1876,316],[1876,2443],[247,2443]],"region":{"top_left_x":247,"top_left_y":315,"width":1629,"height":2128},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d49efab4bee140228e31e024b0dfb0b3","type":"table","conversion_output":true,"children_ids":["6306c259497c4ad2b39e10093dbed4d9","fcd2687f0634490298c00cb5676a599d","bbbfdac7a1284d7ba2223a97381de8bc","fcdbdc994e124ccb849e9e81a5bee32f","ae6b8aeba2a646eebbc1ba32bbe4f6ff","2a3a55c6f7044bfa9a9ffa313ce4a03a","cc71e8d229504dd6951eaa7ed16b4106","a6594f11b9ca4736a020a09e5cbd2419","d5414648d6184cf196a46d3199c76d45","8fbd1103733549c895efadf4cad58829","960fcfad3b6a43d99a6c0727d809e667","87e0e63d792849fc9be393ab4b39ab49","58d205974a454867973e2c654b11b12b","8cc7d93dce084275a9b62bd80e1eff04","32cfd92c665448bfaf2cb806aaa71180","75ed8c2c80454bcaa605b486f09ddd2c","25414bb7b03f48188e43e6e102791a16","d2d397ec159e41fc97bffc725cb6cda1","8a9bffc34c10418d8bc6b2533b1b48d3","59c96f4cd3854f4e8e1378b29b93a3f2","7ef75ac9181c4046a5fb2fd1891cf564","96f4e56d8e3d481fae844a092163fbfd","e68b54a01f3143ceb772454b4f546e9d","82d4251be6634195ad59d7b389198e98","120148ef71a4429c91277d82210d584f","515a2b22e1914954916d20ed22ec39b9","d48d4fac23c54271aa02e262f4d9c39d","8cf3514ae0ad448680e6d7c173e0a1ba","0fcf34321ac84af08daed2c5a71f1fe4","daa224ba32f3452c8d6157c1a9231fbd","2ff50eb2009d4e9a95b7945511eaf324","9fdf49f6553b42ccbb189124a1b9ad91","f9d731c6578544cf92bc6f091e05ff92","3123c6e0440340bf9404eec08cfb4909","f5be8ed16beb4c65b9a8c65e1bb6c933","93a5c6d0cd61456ca17531ec03641368","58684ac11db74168b7376d7c17bec390","14d08197be004bee99dac8e83eb9ed5b","54110ac87fb4427cbdb43803ae41eac1","11a2bb8c1d6244fa86f527e08c04b8c2","70fbe6398e2b4b72a2bf5a1e985c7cd1","e1f6d1186c924b58b9a15b4466b935ee","0ad58d01e4f34236995cccb9349c885e","bf74a61a7c6941fa9336783c08e7775e","f036f36ca7644e5dbee3c846132cdb8b","656333b712a945d0ac15abfa21ed779d","c72adb7dca374ea1bfe0c241b00e4589","cce28edadf2e46adaa53b21a84072a69","f007d1ec87b14991a685a97a12262be2","0ac52f5cc7774b56a121dae11635b85a","1ecc42f4cfaf4cf9a8ecb14e36edaecb","be955ba5d62948e79d6080612cc0b184","5b527de965fc44648decee60cf5a5355","8a94d95ae8504425b9c84ea74cb3e5c4","c5bc534a420c4e83985b6fe212b52716","ddc833d90e444097971d0554589e52b8","a71a2f7815db4456ab3a96687232afee","8290ecd35c474e94b5a7e2ee7faab2fe","515f57a378ac489298e82be00edf02e8","8e2234475c6b42dcae6bb1202c1e8837","a22f2e2bed064097b35f1de6fe0f061f","0283becee8d24371a94629ae841824e2","36d7f397c6444c0dbbd99119639e501b","ab76573cce6d43729bbd0f378a08c3f1","765c6c66ca514b2c8ac63ae3e848e535","13c3b3ca357349fca164644832e1f53b","5c9f2871b11346aa9da6183aa065d428","99d0226ba9724b729c559b16c59abcf0","464cef10e1c348d79e6c3326e6ad1355","c50dd4f4ca884646b3300b5488b3964d","aa25902e033449678a8fe73af14f4e42"],"text":"\\begin{tabular}{|l|l|}\n\\hline EU & European Union \\\\\n\\hline EudraCT & European Union Drug Regulating Authorities Clinical Trials (European clinical trials database) \\\\\n\\hline FDA & Food and Drug Administration \\\\\n\\hline FGF & Fibroblast growth factor \\\\\n\\hline FGF-18 & Fibroblast growth factor-18 \\\\\n\\hline FGFR & Fibroblast growth factor receptor \\\\\n\\hline FIM & First-in-man \\\\\n\\hline FORWARD & FGF-18 Osteoarthritis Randomized trial With Administration of Repeated Doses \\\\\n\\hline GBS & Global Biostatistics (department) \\\\\n\\hline GCDU & Global Clinical Development Unit \\\\\n\\hline GCP & Good Clinical Practice \\\\\n\\hline GDS & Global Drug Safety (department) \\\\\n\\hline GMP & Good Manufacturing Practice \\\\\n\\hline HIV & Human immunodeficiency virus \\\\\n\\hline hsCRP & High-sensitivity C-reactive protein \\\\\n\\hline i.a. & Intra-articular(ly) \\\\\n\\hline IB & Investigator's Brochure \\\\\n\\hline ICF & Informed Consent Form \\\\\n\\hline ICH & International Conference on Harmonization \\\\\n\\hline ICOAP & Measure of Intermittent and Constant Osteoarthritis Pain \\\\\n\\hline IDMC & Independent Data Monitoring Committee \\\\\n\\hline IEC & Independent Ethics Committee \\\\\n\\hline IL & Interleukin \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline EU & European Union \\\\\n\\hline EudraCT & European Union Drug Regulating Authorities Clinical Trials (European clinical trials database) \\\\\n\\hline FDA & Food and Drug Administration \\\\\n\\hline FGF & Fibroblast growth factor \\\\\n\\hline FGF-18 & Fibroblast growth factor-18 \\\\\n\\hline FGFR & Fibroblast growth factor receptor \\\\\n\\hline FIM & First-in-man \\\\\n\\hline FORWARD & FGF-18 Osteoarthritis Randomized trial With Administration of Repeated Doses \\\\\n\\hline GBS & Global Biostatistics (department) \\\\\n\\hline GCDU & Global Clinical Development Unit \\\\\n\\hline GCP & Good Clinical Practice \\\\\n\\hline GDS & Global Drug Safety (department) \\\\\n\\hline GMP & Good Manufacturing Practice \\\\\n\\hline HIV & Human immunodeficiency virus \\\\\n\\hline hsCRP & High-sensitivity C-reactive protein \\\\\n\\hline i.a. & Intra-articular(ly) \\\\\n\\hline IB & Investigator's Brochure \\\\\n\\hline ICF & Informed Consent Form \\\\\n\\hline ICH & International Conference on Harmonization \\\\\n\\hline ICOAP & Measure of Intermittent and Constant Osteoarthritis Pain \\\\\n\\hline IDMC & Independent Data Monitoring Committee \\\\\n\\hline IEC & Independent Ethics Committee \\\\\n\\hline IL & Interleukin \\\\\n\\hline\n\\end{tabular}","confidence":0.9970703125,"confidence_rate":0.999991111282957},{"cnt":[[261,315],[484,315],[484,2443],[261,2443]],"region":{"top_left_x":260,"top_left_y":315,"width":225,"height":2129},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6306c259497c4ad2b39e10093dbed4d9","type":"table_column","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[656,315],[1870,315],[1870,2443],[656,2443]],"region":{"top_left_x":656,"top_left_y":315,"width":1215,"height":2129},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcd2687f0634490298c00cb5676a599d","type":"table_column","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,320],[1873,320],[1873,372],[247,372]],"region":{"top_left_x":247,"top_left_y":320,"width":1627,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbbfdac7a1284d7ba2223a97381de8bc","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,408],[1876,408],[1876,514],[247,514]],"region":{"top_left_x":247,"top_left_y":407,"width":1629,"height":108},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcdbdc994e124ccb849e9e81a5bee32f","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,550],[1876,550],[1876,601],[247,601]],"region":{"top_left_x":247,"top_left_y":549,"width":1629,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae6b8aeba2a646eebbc1ba32bbe4f6ff","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,637],[1876,637],[1876,694],[247,694]],"region":{"top_left_x":247,"top_left_y":636,"width":1629,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a3a55c6f7044bfa9a9ffa313ce4a03a","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,724],[1876,724],[1876,782],[247,782]],"region":{"top_left_x":247,"top_left_y":724,"width":1629,"height":58},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc71e8d229504dd6951eaa7ed16b4106","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,812],[1876,812],[1876,874],[247,874]],"region":{"top_left_x":247,"top_left_y":811,"width":1629,"height":64},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6594f11b9ca4736a020a09e5cbd2419","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,904],[1876,904],[1876,956],[247,956]],"region":{"top_left_x":247,"top_left_y":904,"width":1629,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5414648d6184cf196a46d3199c76d45","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,992],[1876,992],[1876,1103],[247,1103]],"region":{"top_left_x":247,"top_left_y":991,"width":1629,"height":113},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fbd1103733549c895efadf4cad58829","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1131],[1876,1131],[1876,1191],[247,1191]],"region":{"top_left_x":247,"top_left_y":1130,"width":1629,"height":61},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"960fcfad3b6a43d99a6c0727d809e667","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1221],[1876,1221],[1876,1278],[247,1278]],"region":{"top_left_x":247,"top_left_y":1220,"width":1629,"height":59},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87e0e63d792849fc9be393ab4b39ab49","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1311],[1876,1311],[1876,1365],[247,1365]],"region":{"top_left_x":247,"top_left_y":1310,"width":1629,"height":56},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58d205974a454867973e2c654b11b12b","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1401],[1876,1401],[1876,1458],[247,1458]],"region":{"top_left_x":247,"top_left_y":1400,"width":1629,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cc7d93dce084275a9b62bd80e1eff04","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1488],[1876,1488],[1876,1551],[247,1551]],"region":{"top_left_x":247,"top_left_y":1488,"width":1629,"height":63},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32cfd92c665448bfaf2cb806aaa71180","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1575],[1876,1575],[1876,1638],[247,1638]],"region":{"top_left_x":247,"top_left_y":1575,"width":1629,"height":64},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75ed8c2c80454bcaa605b486f09ddd2c","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1668],[1876,1668],[1876,1728],[247,1728]],"region":{"top_left_x":247,"top_left_y":1668,"width":1629,"height":61},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25414bb7b03f48188e43e6e102791a16","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1758],[1873,1758],[1873,1818],[247,1818]],"region":{"top_left_x":247,"top_left_y":1758,"width":1627,"height":61},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2d397ec159e41fc97bffc725cb6cda1","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1848],[1876,1848],[1876,1906],[247,1906]],"region":{"top_left_x":247,"top_left_y":1848,"width":1629,"height":58},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a9bffc34c10418d8bc6b2533b1b48d3","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,1936],[1876,1936],[1876,1990],[247,1990]],"region":{"top_left_x":247,"top_left_y":1935,"width":1629,"height":56},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59c96f4cd3854f4e8e1378b29b93a3f2","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,2026],[1876,2026],[1876,2078],[247,2078]],"region":{"top_left_x":247,"top_left_y":2025,"width":1629,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ef75ac9181c4046a5fb2fd1891cf564","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,2116],[1873,2116],[1873,2168],[247,2168]],"region":{"top_left_x":247,"top_left_y":2115,"width":1627,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96f4e56d8e3d481fae844a092163fbfd","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,2206],[1876,2206],[1876,2263],[247,2263]],"region":{"top_left_x":247,"top_left_y":2205,"width":1629,"height":59},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e68b54a01f3143ceb772454b4f546e9d","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,2296],[1873,2296],[1873,2353],[247,2353]],"region":{"top_left_x":247,"top_left_y":2295,"width":1627,"height":59},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82d4251be6634195ad59d7b389198e98","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,2383],[1876,2383],[1876,2438],[247,2438]],"region":{"top_left_x":247,"top_left_y":2383,"width":1629,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"120148ef71a4429c91277d82210d584f","type":"table_row","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"","text_display":""},{"cnt":[[247,315],[329,315],[329,367],[247,367]],"region":{"top_left_x":247,"top_left_y":315,"width":82,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"515a2b22e1914954916d20ed22ec39b9","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"EU","text_display":"EU","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[656,326],[943,326],[943,372],[656,372]],"region":{"top_left_x":656,"top_left_y":325,"width":287,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d48d4fac23c54271aa02e262f4d9c39d","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"European Union","text_display":"European Union","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,413],[424,413],[424,454],[263,454]],"region":{"top_left_x":263,"top_left_y":413,"width":162,"height":42},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cf3514ae0ad448680e6d7c173e0a1ba","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"EudraCT","text_display":"EudraCT","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9970703125,"confidence_rate":0.9997555309345342},{"cnt":[[656,408],[1868,408],[1868,514],[656,514]],"region":{"top_left_x":656,"top_left_y":407,"width":1212,"height":108},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fcf34321ac84af08daed2c5a71f1fe4","type":"complex_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","children_ids":["695c04bb5d7a486198f5f7a65daec170","e3c39b3da5b14f06bb2b7ff6c5dad4c1"],"text":"European Union Drug Regulating Authorities Clinical Trials (European clinical trials database)","text_display":"European Union Drug Regulating Authorities Clinical Trials (European clinical trials database)","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,413],[1859,413],[1859,460],[662,460]],"region":{"top_left_x":661,"top_left_y":413,"width":1199,"height":47},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"695c04bb5d7a486198f5f7a65daec170","type":"text","conversion_output":false,"parent_id":"0fcf34321ac84af08daed2c5a71f1fe4","text":"European Union Drug Regulating Authorities Clinical Trials","text_display":"European Union Drug Regulating Authorities Clinical Trials","confidence":1,"confidence_rate":1},{"cnt":[[662,462],[1237,462],[1237,509],[662,509]],"region":{"top_left_x":661,"top_left_y":462,"width":577,"height":47},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3c39b3da5b14f06bb2b7ff6c5dad4c1","type":"text","conversion_output":false,"parent_id":"0fcf34321ac84af08daed2c5a71f1fe4","text":"(European clinical trials database)","text_display":" (European clinical trials database)","confidence":1,"confidence_rate":1},{"cnt":[[263,550],[356,550],[356,593],[263,593]],"region":{"top_left_x":263,"top_left_y":549,"width":94,"height":45},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"daa224ba32f3452c8d6157c1a9231fbd","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"FDA","text_display":"FDA","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,550],[1183,550],[1183,601],[662,601]],"region":{"top_left_x":661,"top_left_y":549,"width":522,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ff50eb2009d4e9a95b7945511eaf324","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Food and Drug Administration","text_display":"Food and Drug Administration","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,642],[351,642],[351,686],[263,686]],"region":{"top_left_x":263,"top_left_y":642,"width":88,"height":45},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fdf49f6553b42ccbb189124a1b9ad91","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"FGF","text_display":"FGF","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,642],[1074,642],[1074,689],[662,689]],"region":{"top_left_x":661,"top_left_y":642,"width":413,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9d731c6578544cf92bc6f091e05ff92","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Fibroblast growth factor","text_display":"Fibroblast growth factor","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,730],[403,730],[403,771],[263,771]],"region":{"top_left_x":263,"top_left_y":729,"width":140,"height":42},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3123c6e0440340bf9404eec08cfb4909","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"FGF-18","text_display":"FGF-18","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,730],[1128,730],[1128,776],[662,776]],"region":{"top_left_x":661,"top_left_y":729,"width":468,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5be8ed16beb4c65b9a8c65e1bb6c933","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Fibroblast growth factor-18","text_display":"Fibroblast growth factor-18","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,822],[378,822],[378,861],[263,861]],"region":{"top_left_x":263,"top_left_y":822,"width":115,"height":39},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93a5c6d0cd61456ca17531ec03641368","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"FGFR","text_display":"FGFR","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,820],[1221,820],[1221,869],[662,869]],"region":{"top_left_x":661,"top_left_y":819,"width":561,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58684ac11db74168b7376d7c17bec390","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Fibroblast growth factor receptor","text_display":"Fibroblast growth factor receptor","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,910],[351,910],[351,953],[263,953]],"region":{"top_left_x":263,"top_left_y":909,"width":88,"height":45},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14d08197be004bee99dac8e83eb9ed5b","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"FIM","text_display":"FIM","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,910],[877,910],[877,951],[662,951]],"region":{"top_left_x":661,"top_left_y":909,"width":217,"height":42},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54110ac87fb4427cbdb43803ae41eac1","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"First-in-man","text_display":"First-in-man","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,997],[479,997],[479,1038],[263,1038]],"region":{"top_left_x":263,"top_left_y":997,"width":216,"height":42},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11a2bb8c1d6244fa86f527e08c04b8c2","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"FORWARD","text_display":"FORWARD","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[656,994],[1870,994],[1870,1098],[656,1098]],"region":{"top_left_x":656,"top_left_y":994,"width":1215,"height":105},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70fbe6398e2b4b72a2bf5a1e985c7cd1","type":"complex_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","children_ids":["fe43fe89564f4402b5f1763ccf83f9bb","9cadcbae121e44aabafa62c5072574cb"],"text":"FGF-18 Osteoarthritis Randomized trial With Administration of Repeated Doses","text_display":"FGF-18 Osteoarthritis Randomized trial With Administration of Repeated Doses","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.998046875,"confidence_rate":0.9999851892397121},{"cnt":[[662,997],[1865,997],[1865,1041],[662,1041]],"region":{"top_left_x":661,"top_left_y":997,"width":1204,"height":44},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe43fe89564f4402b5f1763ccf83f9bb","type":"text","conversion_output":false,"parent_id":"70fbe6398e2b4b72a2bf5a1e985c7cd1","text":"FGF-18 Osteoarthritis Randomized trial With Administration of","text_display":"FGF-18 Osteoarthritis Randomized trial With Administration of","confidence":0.998046875,"confidence_rate":0.999970378698783},{"cnt":[[662,1046],[935,1046],[935,1093],[662,1093]],"region":{"top_left_x":661,"top_left_y":1046,"width":274,"height":47},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cadcbae121e44aabafa62c5072574cb","type":"text","conversion_output":false,"parent_id":"70fbe6398e2b4b72a2bf5a1e985c7cd1","text":"Repeated Doses","text_display":" Repeated Doses","confidence":1,"confidence_rate":1},{"cnt":[[263,1139],[356,1139],[356,1177],[263,1177]],"region":{"top_left_x":263,"top_left_y":1138,"width":94,"height":40},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1f6d1186c924b58b9a15b4466b935ee","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"GBS","text_display":"GBS","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,1134],[1221,1134],[1221,1185],[662,1185]],"region":{"top_left_x":661,"top_left_y":1133,"width":561,"height":53},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ad58d01e4f34236995cccb9349c885e","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Global Biostatistics (department)","text_display":"Global Biostatistics (department)","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,1226],[392,1226],[392,1267],[263,1267]],"region":{"top_left_x":263,"top_left_y":1226,"width":129,"height":42},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf74a61a7c6941fa9336783c08e7775e","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"GCDU","text_display":"GCDU","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,1226],[1243,1226],[1243,1273],[662,1273]],"region":{"top_left_x":661,"top_left_y":1226,"width":582,"height":47},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f036f36ca7644e5dbee3c846132cdb8b","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Global Clinical Development Unit","text_display":"Global Clinical Development Unit","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,1314],[356,1314],[356,1357],[263,1357]],"region":{"top_left_x":263,"top_left_y":1313,"width":94,"height":45},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"656333b712a945d0ac15abfa21ed779d","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"GCP","text_display":"GCP","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,1314],[1046,1314],[1046,1354],[662,1354]],"region":{"top_left_x":661,"top_left_y":1313,"width":386,"height":42},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c72adb7dca374ea1bfe0c241b00e4589","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Good Clinical Practice","text_display":"Good Clinical Practice","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,1406],[356,1406],[356,1450],[263,1450]],"region":{"top_left_x":263,"top_left_y":1406,"width":94,"height":44},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cce28edadf2e46adaa53b21a84072a69","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"GDS","text_display":"GDS","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,1406],[1218,1406],[1218,1453],[662,1453]],"region":{"top_left_x":661,"top_left_y":1406,"width":558,"height":47},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f007d1ec87b14991a685a97a12262be2","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Global Drug Safety (department)","text_display":"Global Drug Safety (department)","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,1494],[362,1494],[362,1537],[263,1537]],"region":{"top_left_x":263,"top_left_y":1493,"width":99,"height":45},"line":58,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ac52f5cc7774b56a121dae11635b85a","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"GMP","text_display":"GMP","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,1494],[1166,1494],[1166,1543],[662,1543]],"region":{"top_left_x":661,"top_left_y":1493,"width":506,"height":50},"line":59,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ecc42f4cfaf4cf9a8ecb14e36edaecb","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Good Manufacturing Practice","text_display":"Good Manufacturing Practice","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,1586],[348,1586],[348,1625],[263,1625]],"region":{"top_left_x":263,"top_left_y":1586,"width":85,"height":39},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be955ba5d62948e79d6080612cc0b184","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"HIV","text_display":"HIV","cell_row":13,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,1584],[1210,1584],[1210,1633],[662,1633]],"region":{"top_left_x":661,"top_left_y":1583,"width":550,"height":50},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b527de965fc44648decee60cf5a5355","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Human immunodeficiency virus","text_display":"Human immunodeficiency virus","cell_row":13,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,1674],[386,1674],[386,1715],[263,1715]],"region":{"top_left_x":263,"top_left_y":1673,"width":124,"height":42},"line":62,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a94d95ae8504425b9c84ea74cb3e5c4","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"hsCRP","text_display":"hsCRP","cell_row":14,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[659,1674],[1248,1674],[1248,1720],[659,1720]],"region":{"top_left_x":658,"top_left_y":1673,"width":591,"height":48},"line":63,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5bc534a420c4e83985b6fe212b52716","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"High-sensitivity C-reactive protein","text_display":"High-sensitivity C-reactive protein","cell_row":14,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1764],[323,1764],[323,1810],[247,1810]],"region":{"top_left_x":247,"top_left_y":1763,"width":77,"height":48},"line":64,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddc833d90e444097971d0554589e52b8","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"i.a.","text_display":"i.a.","cell_row":15,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999457347503998},{"cnt":[[662,1761],[959,1761],[959,1810],[662,1810]],"region":{"top_left_x":661,"top_left_y":1761,"width":299,"height":50},"line":65,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a71a2f7815db4456ab3a96687232afee","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Intra-articular(ly)","text_display":"Intra-articular(ly)","cell_row":15,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1854],[318,1854],[318,1900],[247,1900]],"region":{"top_left_x":247,"top_left_y":1853,"width":71,"height":48},"line":66,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8290ecd35c474e94b5a7e2ee7faab2fe","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"IB","text_display":"IB","cell_row":16,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,1854],[1063,1854],[1063,1900],[662,1900]],"region":{"top_left_x":661,"top_left_y":1853,"width":402,"height":48},"line":67,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"515f57a378ac489298e82be00edf02e8","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Investigator's Brochure","text_display":"Investigator's Brochure","cell_row":16,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99755859375,"confidence_rate":0.9999127041197294},{"cnt":[[263,1941],[340,1941],[340,1985],[263,1985]],"region":{"top_left_x":263,"top_left_y":1941,"width":77,"height":44},"line":68,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e2234475c6b42dcae6bb1202c1e8837","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"ICF","text_display":"ICF","cell_row":17,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,1941],[1071,1941],[1071,1982],[662,1982]],"region":{"top_left_x":661,"top_left_y":1941,"width":410,"height":42},"line":69,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a22f2e2bed064097b35f1de6fe0f061f","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Informed Consent Form","text_display":"Informed Consent Form","cell_row":17,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,2031],[345,2031],[345,2072],[263,2072]],"region":{"top_left_x":263,"top_left_y":2031,"width":83,"height":42},"line":70,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0283becee8d24371a94629ae841824e2","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"ICH","text_display":"ICH","cell_row":18,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,2028],[1398,2028],[1398,2072],[662,2072]],"region":{"top_left_x":661,"top_left_y":2028,"width":738,"height":45},"line":71,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36d7f397c6444c0dbbd99119639e501b","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"International Conference on Harmonization","text_display":"International Conference on Harmonization","cell_row":18,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,2121],[397,2121],[397,2162],[263,2162]],"region":{"top_left_x":263,"top_left_y":2121,"width":135,"height":42},"line":72,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab76573cce6d43729bbd0f378a08c3f1","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"ICOAP","text_display":"ICOAP","cell_row":19,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,2121],[1617,2121],[1617,2162],[662,2162]],"region":{"top_left_x":661,"top_left_y":2121,"width":956,"height":42},"line":73,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"765c6c66ca514b2c8ac63ae3e848e535","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Measure of Intermittent and Constant Osteoarthritis Pain","text_display":"Measure of Intermittent and Constant Osteoarthritis Pain","cell_row":19,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999919934665097},{"cnt":[[263,2208],[381,2208],[381,2249],[263,2249]],"region":{"top_left_x":263,"top_left_y":2208,"width":118,"height":42},"line":74,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13c3b3ca357349fca164644832e1f53b","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"IDMC","text_display":"IDMC","cell_row":20,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,2208],[1363,2208],[1363,2260],[662,2260]],"region":{"top_left_x":661,"top_left_y":2208,"width":702,"height":53},"line":75,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c9f2871b11346aa9da6183aa065d428","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Independent Data Monitoring Committee","text_display":"Independent Data Monitoring Committee","cell_row":20,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[263,2301],[340,2301],[340,2345],[263,2345]],"region":{"top_left_x":263,"top_left_y":2301,"width":77,"height":44},"line":76,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99d0226ba9724b729c559b16c59abcf0","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"IEC","text_display":"IEC","cell_row":21,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,2301],[1188,2301],[1188,2348],[662,2348]],"region":{"top_left_x":661,"top_left_y":2301,"width":528,"height":47},"line":77,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"464cef10e1c348d79e6c3326e6ad1355","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Independent Ethics Committee","text_display":"Independent Ethics Committee","cell_row":21,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2394],[312,2394],[312,2432],[247,2432]],"region":{"top_left_x":247,"top_left_y":2393,"width":66,"height":40},"line":78,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c50dd4f4ca884646b3300b5488b3964d","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"IL","text_display":"IL","cell_row":22,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,2389],[850,2389],[850,2429],[662,2429]],"region":{"top_left_x":661,"top_left_y":2388,"width":189,"height":42},"line":79,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa25902e033449678a8fe73af14f4e42","type":"simple_cell","conversion_output":false,"parent_id":"d49efab4bee140228e31e024b0dfb0b3","text":"Interleukin","text_display":"Interleukin","cell_row":22,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":80,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"dc57929506b34ba3a6e839d2b178c07a","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":81,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2be1d8ea302c4511b1e95b59ecb0c0d9","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2529],[1605,2529],[1605,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2528,"width":97,"height":36},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d2e8a3570344b42925448e2b446390a","type":"page_info","conversion_output":false,"text":"13/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-014","page":14,"lines":[{"cnt":[[245,129],[434,129],[434,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":190,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df711b29e1df4827b05b78585975b812","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a3744c12b404b8c88f6c84e78adfa63","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1890658afc94474f8dd648a5304256a4","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[247,316],[1843,316],[1843,2434],[247,2434]],"region":{"top_left_x":247,"top_left_y":315,"width":1597,"height":2120},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","type":"table","conversion_output":true,"children_ids":["6fddc62254914832abebb1e159730bb6","680d0230723147f5b81cb2e335035dcb","3529bf22f2a940888136a2cf83929faf","6088592a7f9a478292598f150725f745","b18bc3969f634df2a64bb3d3feb76af2","f4eca5f981e44a43a98589fe9532c9e6","5008ffb3fd034303a969bdcbd6eb2079","f1df72be86534c918f11c27a6416345e","8450f8fe3f374173b91ac3ee6e99bcf9","fb209e5cecc54ea08ddfbfacafaaf7d4","13cb9b906a0f44fea2b400d7209f96ae","714e5c013181433c9296938eac983036","0aa6cc189e424d0d97144ab1297de053","1a2fa5885b054ca298033f22c80ed3c4","85ff4e97560d4b6f861140373c8842ef","6001e6d87cf54346a7bc4a5b4eefc93e","c9d97254363741f6ad55815a211c7d85","aeff6881b2254ef8a236bb8d1e8b5ea8","c18b15b7bedf4b1f86425f84f5608ae0","1c9cc04a464548ffbdcbab7d3731afa5","ca21b03bd2e14d36a8c45302eb515659","5a2ce2bc550a4950ae15345b2d3b561d","2d2eae3250514179b8259daf8c04fc04","6300816a2b914bfbbeb6696e49cb0f80","1aa8add2b5be4cdfb23b21d3497df206","7ebc198eb9b240b685a052e5d72aa422","095ad61ff78b417db4923381936e6682","1fb224c2b8094b908ebc23b419a9eb2c","8350659b9ec54518a8a5a498f0b7f361","0d34a36909664cf09d8341c525803908","5c1a8843a0884dfb9da80a13a2caaacd","1fc15b50877645b6bc867802fa696d4b","98a29c2c07684c3296613969f2677858","1722bdceccc747e59c784f7c1721afc9","1bdb10f7940745e5bc70e06f0ae6fff3","3225126a7548411198c894f9a4ee6771","78c6a7638e5b4b7595c70efc983ef04a","7e8aaa71d5334f1d99ac98636ad72c42","51faf9694b6042b98875935dc2625ccd","7c75971e9aa9423092bf07ab02203504","f17d798e048d4d21937389b069b5e593","434feb6e32474ff98f3541b231133f97","77b1d6c35b5943d2bbce4837afe4fd4d","c58aacffaa844e69be93768ac1af6f77","93bda9459365426a90645b57ad17f844","f729d5d73deb47fead147011e3c528a0","3ab10b893ec04a4e873a2dcf77796661","fa9fd920966d49faa2f26e7dbccc3924","1cba373100d8403bbe66b65d289ab61d","b9e2386f8485404e9890fd276a3eaeaf","65ae7995e6e1416c959e6e06023112b0","d5e438e960674a679d783034dd2c850d","c00652ea61b3484e852b1d66cf2093fa","3a81b504e4174c2f8565eeb142e953c5","b5cd2b3a6ae142be9fb55c9941c122af","1032eb6c2bbe4ce19c3cf12d21f3fee2","eb7bcbd42fdd4a3cb627c7016d797e9c","9510163cbc8642719a44682fedb81f58","8633478b67454a89b80b8ba38a5dbf0d","2b90a9404cb047e58cd0707aa22ed43f","beddfa53d4de4ea8a855f15598d3e1f9","363315c6fbc841a6a3c49b97293b667f","fc6a5ce9d4e44686a93e9cde46bce93b","b0eae3826aa54e1daa1f5f2aa2fbaeb7","8a2a6d308af84a3db59cc8d4517b44e3","11505a0e1b9b4896b4f9c8df536b486f","fe69a7a730ee478584635364d9da9d1b","4e216ba751c149ba8652242e573d269a","464e2ea8486f4a80972d6703de2818c3","ca17abb4b40d4cfead106f96cf775560","2b17a30540084364a4b6b63003d5a5fd","c79225c1b21d43338e4ff6191fce3c5a","2b8e3b2a31bd4dd488d130c8565f023f","f8ef5e56655940a7b19505275f8cd701"],"text":"\\begin{tabular}{|l|l|}\n\\hline IL-1ra & Interleukin-1 receptor antagonist \\\\\n\\hline IMP & Investigational Medicinal Product \\\\\n\\hline IND & Investigational New Drug \\\\\n\\hline IRB & Institutional Review Board \\\\\n\\hline ITT & Intention-to-Treat \\\\\n\\hline IVRS & Interactive Voice Response System \\\\\n\\hline JSW & Joint space width \\\\\n\\hline KOOS & Knee Injury and Osteoarthritis Outcome Score \\\\\n\\hline KOOS QOL & Knee Injury and Osteoarthritis Outcome Score quality of life subscale \\\\\n\\hline LFTC & Lateral femorotibial compartment \\\\\n\\hline LLOQ & Lower limit of quantitation \\\\\n\\hline mcg & Microgram(s) \\\\\n\\hline MedDRA & Medical Dictionary for Regulatory Activities \\\\\n\\hline MFTC & Medial femorotibial compartment \\\\\n\\hline mITT & Modified Intention-to-Treat \\\\\n\\hline MOP & Manual of Operations \\\\\n\\hline MOS SF-36 & Medical Outcomes Study Short Form-36 General Health Survey \\\\\n\\hline MRI & Magnetic resonance imaging \\\\\n\\hline NCD & Non-Clinical Development (department) \\\\\n\\hline N.B. & Nota bene (please note) \\\\\n\\hline NRS & Numerical Rating Scale \\\\\n\\hline NSAID & Non-steroidal anti-inflammatory drug \\\\\n\\hline OA & Osteoarthritis \\\\\n\\hline OAI & Osteoarthritis Initiative \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline IL-1ra & Interleukin-1 receptor antagonist \\\\\n\\hline IMP & Investigational Medicinal Product \\\\\n\\hline IND & Investigational New Drug \\\\\n\\hline IRB & Institutional Review Board \\\\\n\\hline ITT & Intention-to-Treat \\\\\n\\hline IVRS & Interactive Voice Response System \\\\\n\\hline JSW & Joint space width \\\\\n\\hline KOOS & Knee Injury and Osteoarthritis Outcome Score \\\\\n\\hline KOOS QOL & Knee Injury and Osteoarthritis Outcome Score quality of life subscale \\\\\n\\hline LFTC & Lateral femorotibial compartment \\\\\n\\hline LLOQ & Lower limit of quantitation \\\\\n\\hline mcg & Microgram(s) \\\\\n\\hline MedDRA & Medical Dictionary for Regulatory Activities \\\\\n\\hline MFTC & Medial femorotibial compartment \\\\\n\\hline mITT & Modified Intention-to-Treat \\\\\n\\hline MOP & Manual of Operations \\\\\n\\hline MOS SF-36 & Medical Outcomes Study Short Form-36 General Health Survey \\\\\n\\hline MRI & Magnetic resonance imaging \\\\\n\\hline NCD & Non-Clinical Development (department) \\\\\n\\hline N.B. & Nota bene (please note) \\\\\n\\hline NRS & Numerical Rating Scale \\\\\n\\hline NSAID & Non-steroidal anti-inflammatory drug \\\\\n\\hline OA & Osteoarthritis \\\\\n\\hline OAI & Osteoarthritis Initiative \\\\\n\\hline\n\\end{tabular}","confidence":0.99853515625,"confidence_rate":0.999996860252454},{"cnt":[[258,315],[485,315],[485,2435],[258,2435]],"region":{"top_left_x":257,"top_left_y":315,"width":229,"height":2121},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fddc62254914832abebb1e159730bb6","type":"table_column","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[654,315],[1836,315],[1836,2435],[654,2435]],"region":{"top_left_x":654,"top_left_y":315,"width":1183,"height":2121},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"680d0230723147f5b81cb2e335035dcb","type":"table_column","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,319],[1843,319],[1843,376],[247,376]],"region":{"top_left_x":247,"top_left_y":319,"width":1596,"height":57},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3529bf22f2a940888136a2cf83929faf","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,408],[1843,408],[1843,464],[247,464]],"region":{"top_left_x":247,"top_left_y":408,"width":1596,"height":57},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6088592a7f9a478292598f150725f745","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,499],[1843,499],[1843,553],[247,553]],"region":{"top_left_x":247,"top_left_y":499,"width":1596,"height":55},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b18bc3969f634df2a64bb3d3feb76af2","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,588],[1843,588],[1843,640],[247,640]],"region":{"top_left_x":247,"top_left_y":587,"width":1596,"height":53},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4eca5f981e44a43a98589fe9532c9e6","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,679],[1843,679],[1843,726],[247,726]],"region":{"top_left_x":247,"top_left_y":678,"width":1596,"height":49},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5008ffb3fd034303a969bdcbd6eb2079","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,768],[1843,768],[1843,824],[247,824]],"region":{"top_left_x":247,"top_left_y":767,"width":1596,"height":57},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1df72be86534c918f11c27a6416345e","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,856],[1843,856],[1843,911],[247,911]],"region":{"top_left_x":247,"top_left_y":856,"width":1596,"height":55},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8450f8fe3f374173b91ac3ee6e99bcf9","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,947],[1843,947],[1843,1001],[247,1001]],"region":{"top_left_x":247,"top_left_y":947,"width":1596,"height":55},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb209e5cecc54ea08ddfbfacafaaf7d4","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1036],[1843,1036],[1843,1092],[247,1092]],"region":{"top_left_x":247,"top_left_y":1036,"width":1596,"height":57},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13cb9b906a0f44fea2b400d7209f96ae","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1125],[1843,1125],[1843,1179],[247,1179]],"region":{"top_left_x":247,"top_left_y":1124,"width":1596,"height":56},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"714e5c013181433c9296938eac983036","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1216],[1843,1216],[1843,1270],[247,1270]],"region":{"top_left_x":247,"top_left_y":1215,"width":1596,"height":55},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0aa6cc189e424d0d97144ab1297de053","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1307],[1843,1307],[1843,1359],[247,1359]],"region":{"top_left_x":247,"top_left_y":1306,"width":1596,"height":53},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a2fa5885b054ca298033f22c80ed3c4","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1393],[1843,1393],[1843,1450],[247,1450]],"region":{"top_left_x":247,"top_left_y":1393,"width":1596,"height":57},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85ff4e97560d4b6f861140373c8842ef","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1484],[1843,1484],[1843,1539],[247,1539]],"region":{"top_left_x":247,"top_left_y":1484,"width":1596,"height":55},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6001e6d87cf54346a7bc4a5b4eefc93e","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1571],[1843,1571],[1843,1625],[247,1625]],"region":{"top_left_x":247,"top_left_y":1570,"width":1596,"height":56},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9d97254363741f6ad55815a211c7d85","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1662],[1843,1662],[1843,1720],[247,1720]],"region":{"top_left_x":247,"top_left_y":1661,"width":1596,"height":60},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aeff6881b2254ef8a236bb8d1e8b5ea8","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1749],[1843,1749],[1843,1809],[247,1809]],"region":{"top_left_x":247,"top_left_y":1748,"width":1596,"height":62},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c18b15b7bedf4b1f86425f84f5608ae0","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1842],[1843,1842],[1843,1898],[247,1898]],"region":{"top_left_x":247,"top_left_y":1841,"width":1596,"height":57},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c9cc04a464548ffbdcbab7d3731afa5","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,1930],[1843,1930],[1843,1989],[247,1989]],"region":{"top_left_x":247,"top_left_y":1930,"width":1596,"height":59},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca21b03bd2e14d36a8c45302eb515659","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,2021],[1843,2021],[1843,2078],[247,2078]],"region":{"top_left_x":247,"top_left_y":2021,"width":1596,"height":57},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a2ce2bc550a4950ae15345b2d3b561d","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,2110],[1843,2110],[1843,2166],[247,2166]],"region":{"top_left_x":247,"top_left_y":2110,"width":1596,"height":57},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d2eae3250514179b8259daf8c04fc04","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,2199],[1843,2199],[1843,2257],[247,2257]],"region":{"top_left_x":247,"top_left_y":2198,"width":1596,"height":60},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6300816a2b914bfbbeb6696e49cb0f80","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,2290],[1843,2290],[1843,2340],[247,2340]],"region":{"top_left_x":247,"top_left_y":2289,"width":1596,"height":51},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1aa8add2b5be4cdfb23b21d3497df206","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[247,2379],[1843,2379],[1843,2431],[247,2431]],"region":{"top_left_x":247,"top_left_y":2378,"width":1596,"height":53},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ebc198eb9b240b685a052e5d72aa422","type":"table_row","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"","text_display":""},{"cnt":[[264,324],[379,324],[379,365],[264,365]],"region":{"top_left_x":264,"top_left_y":323,"width":116,"height":42},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"095ad61ff78b417db4923381936e6682","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"IL-1ra","text_display":"IL-1ra","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9998667436355548},{"cnt":[[658,324],[1215,324],[1215,371],[658,371]],"region":{"top_left_x":658,"top_left_y":323,"width":557,"height":49},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fb224c2b8094b908ebc23b419a9eb2c","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Interleukin-1 receptor antagonist","text_display":"Interleukin-1 receptor antagonist","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,402],[344,402],[344,451],[264,451]],"region":{"top_left_x":264,"top_left_y":401,"width":81,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8350659b9ec54518a8a5a498f0b7f361","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"IMP","text_display":"IMP","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,415],[1237,415],[1237,460],[658,460]],"region":{"top_left_x":658,"top_left_y":414,"width":579,"height":47},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d34a36909664cf09d8341c525803908","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Investigational Medicinal Product","text_display":"Investigational Medicinal Product","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,506],[344,506],[344,542],[264,542]],"region":{"top_left_x":264,"top_left_y":505,"width":81,"height":38},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c1a8843a0884dfb9da80a13a2caaacd","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"IND","text_display":"IND","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,501],[1102,501],[1102,551],[658,551]],"region":{"top_left_x":658,"top_left_y":501,"width":445,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fc15b50877645b6bc867802fa696d4b","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Investigational New Drug","text_display":"Investigational New Drug","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,592],[340,592],[340,633],[264,633]],"region":{"top_left_x":264,"top_left_y":592,"width":77,"height":42},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98a29c2c07684c3296613969f2677858","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"IRB","text_display":"IRB","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,592],[1120,592],[1120,633],[658,633]],"region":{"top_left_x":658,"top_left_y":592,"width":462,"height":42},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1722bdceccc747e59c784f7c1721afc9","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Institutional Review Board","text_display":"Institutional Review Board","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,683],[338,683],[338,724],[264,724]],"region":{"top_left_x":264,"top_left_y":683,"width":74,"height":42},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1bdb10f7940745e5bc70e06f0ae6fff3","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"ITT","text_display":"ITT","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,683],[968,683],[968,724],[658,724]],"region":{"top_left_x":658,"top_left_y":683,"width":311,"height":42},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3225126a7548411198c894f9a4ee6771","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Intention-to-Treat","text_display":"Intention-to-Treat","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,772],[366,772],[366,811],[264,811]],"region":{"top_left_x":264,"top_left_y":771,"width":103,"height":40},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78c6a7638e5b4b7595c70efc983ef04a","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"IVRS","text_display":"IVRS","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,770],[1258,770],[1258,820],[658,820]],"region":{"top_left_x":658,"top_left_y":769,"width":601,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e8aaa71d5334f1d99ac98636ad72c42","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Interactive Voice Response System","text_display":"Interactive Voice Response System","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,861],[353,861],[353,902],[264,902]],"region":{"top_left_x":264,"top_left_y":860,"width":90,"height":42},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51faf9694b6042b98875935dc2625ccd","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"JSW","text_display":"JSW","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,861],[959,861],[959,911],[658,911]],"region":{"top_left_x":658,"top_left_y":860,"width":302,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c75971e9aa9423092bf07ab02203504","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Joint space width","text_display":"Joint space width","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,952],[388,952],[388,993],[264,993]],"region":{"top_left_x":264,"top_left_y":951,"width":124,"height":42},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f17d798e048d4d21937389b069b5e593","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"KOOS","text_display":"KOOS","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,949],[1445,949],[1445,999],[658,999]],"region":{"top_left_x":658,"top_left_y":949,"width":787,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"434feb6e32474ff98f3541b231133f97","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Knee Injury and Osteoarthritis Outcome Score","text_display":"Knee Injury and Osteoarthritis Outcome Score","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1038],[483,1038],[483,1088],[264,1088]],"region":{"top_left_x":264,"top_left_y":1038,"width":220,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77b1d6c35b5943d2bbce4837afe4fd4d","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"KOOS QOL","text_display":"KOOS QOL","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1038],[1834,1038],[1834,1088],[658,1088]],"region":{"top_left_x":658,"top_left_y":1038,"width":1177,"height":51},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c58aacffaa844e69be93768ac1af6f77","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Knee Injury and Osteoarthritis Outcome Score quality of life subscale","text_display":"Knee Injury and Osteoarthritis Outcome Score quality of life subscale","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1129],[375,1129],[375,1170],[264,1170]],"region":{"top_left_x":264,"top_left_y":1129,"width":111,"height":42},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93bda9459365426a90645b57ad17f844","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"LFTC","text_display":"LFTC","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1129],[1237,1129],[1237,1179],[658,1179]],"region":{"top_left_x":658,"top_left_y":1129,"width":579,"height":51},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f729d5d73deb47fead147011e3c528a0","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Lateral femorotibial compartment","text_display":"Lateral femorotibial compartment","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1220],[383,1220],[383,1266],[264,1266]],"region":{"top_left_x":264,"top_left_y":1220,"width":120,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ab10b893ec04a4e873a2dcf77796661","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"LLOQ","text_display":"LLOQ","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1220],[1122,1220],[1122,1270],[658,1270]],"region":{"top_left_x":658,"top_left_y":1220,"width":464,"height":50},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa9fd920966d49faa2f26e7dbccc3924","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Lower limit of quantitation","text_display":"Lower limit of quantitation","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1315],[344,1315],[344,1357],[264,1357]],"region":{"top_left_x":264,"top_left_y":1315,"width":81,"height":42},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cba373100d8403bbe66b65d289ab61d","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"mcg","text_display":"mcg","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1307],[899,1307],[899,1357],[658,1357]],"region":{"top_left_x":658,"top_left_y":1306,"width":241,"height":51},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9e2386f8485404e9890fd276a3eaeaf","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Microgram(s)","text_display":"Microgram(s)","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1398],[440,1398],[440,1439],[264,1439]],"region":{"top_left_x":264,"top_left_y":1397,"width":176,"height":42},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65ae7995e6e1416c959e6e06023112b0","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"MedDRA","text_display":"MedDRA","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1398],[1419,1398],[1419,1448],[658,1448]],"region":{"top_left_x":658,"top_left_y":1397,"width":761,"height":51},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5e438e960674a679d783034dd2c850d","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Medical Dictionary for Regulatory Activities","text_display":"Medical Dictionary for Regulatory Activities","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1489],[388,1489],[388,1530],[264,1530]],"region":{"top_left_x":264,"top_left_y":1488,"width":124,"height":42},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c00652ea61b3484e852b1d66cf2093fa","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"MFTC","text_display":"MFTC","cell_row":13,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1487],[1237,1487],[1237,1536],[658,1536]],"region":{"top_left_x":658,"top_left_y":1486,"width":579,"height":51},"line":58,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a81b504e4174c2f8565eeb142e953c5","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Medial femorotibial compartment","text_display":"Medial femorotibial compartment","cell_row":13,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1575],[370,1575],[370,1621],[264,1621]],"region":{"top_left_x":264,"top_left_y":1575,"width":107,"height":46},"line":59,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5cd2b3a6ae142be9fb55c9941c122af","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"mITT","text_display":"mITT","cell_row":14,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1575],[1133,1575],[1133,1621],[658,1621]],"region":{"top_left_x":658,"top_left_y":1575,"width":475,"height":46},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1032eb6c2bbe4ce19c3cf12d21f3fee2","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Modified Intention-to-Treat","text_display":"Modified Intention-to-Treat","cell_row":14,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[260,1666],[362,1666],[362,1707],[260,1707]],"region":{"top_left_x":259,"top_left_y":1666,"width":103,"height":42},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb7bcbd42fdd4a3cb627c7016d797e9c","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"MOP","text_display":"MOP","cell_row":15,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1666],[1033,1666],[1033,1716],[658,1716]],"region":{"top_left_x":658,"top_left_y":1666,"width":376,"height":51},"line":62,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9510163cbc8642719a44682fedb81f58","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Manual of Operations","text_display":"Manual of Operations","cell_row":15,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[260,1757],[474,1757],[474,1798],[260,1798]],"region":{"top_left_x":259,"top_left_y":1757,"width":216,"height":42},"line":63,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8633478b67454a89b80b8ba38a5dbf0d","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"MOS SF-36","text_display":"MOS SF-36","cell_row":16,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1755],[1743,1755],[1743,1807],[658,1807]],"region":{"top_left_x":658,"top_left_y":1755,"width":1086,"height":53},"line":64,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b90a9404cb047e58cd0707aa22ed43f","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Medical Outcomes Study Short Form-36 General Health Survey","text_display":"Medical Outcomes Study Short Form-36 General Health Survey","cell_row":16,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[260,1846],[353,1846],[353,1887],[260,1887]],"region":{"top_left_x":259,"top_left_y":1846,"width":95,"height":42},"line":65,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"beddfa53d4de4ea8a855f15598d3e1f9","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"MRI","text_display":"MRI","cell_row":17,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1844],[1150,1844],[1150,1894],[658,1894]],"region":{"top_left_x":658,"top_left_y":1843,"width":493,"height":51},"line":66,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"363315c6fbc841a6a3c49b97293b667f","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Magnetic resonance imaging","text_display":"Magnetic resonance imaging","cell_row":17,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[260,1935],[362,1935],[362,1976],[260,1976]],"region":{"top_left_x":259,"top_left_y":1934,"width":103,"height":42},"line":67,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc6a5ce9d4e44686a93e9cde46bce93b","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"NCD","text_display":"NCD","cell_row":18,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,1935],[1345,1935],[1345,1985],[658,1985]],"region":{"top_left_x":658,"top_left_y":1934,"width":687,"height":51},"line":68,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0eae3826aa54e1daa1f5f2aa2fbaeb7","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Non-Clinical Development (department)","text_display":"Non-Clinical Development (department)","cell_row":18,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[260,2026],[349,2026],[349,2067],[260,2067]],"region":{"top_left_x":259,"top_left_y":2025,"width":90,"height":42},"line":69,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a2a6d308af84a3db59cc8d4517b44e3","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"N.B.","text_display":"N.B.","cell_row":19,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,2026],[1063,2026],[1063,2076],[658,2076]],"region":{"top_left_x":658,"top_left_y":2025,"width":406,"height":51},"line":70,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11505a0e1b9b4896b4f9c8df536b486f","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Nota bene (please note)","text_display":"Nota bene (please note)","cell_row":19,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999825572771935},{"cnt":[[260,2117],[353,2117],[353,2158],[260,2158]],"region":{"top_left_x":259,"top_left_y":2116,"width":95,"height":42},"line":71,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe69a7a730ee478584635364d9da9d1b","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"NRS","text_display":"NRS","cell_row":20,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,2112],[1068,2112],[1068,2162],[658,2162]],"region":{"top_left_x":658,"top_left_y":2112,"width":410,"height":51},"line":72,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e216ba751c149ba8652242e573d269a","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Numerical Rating Scale","text_display":"Numerical Rating Scale","cell_row":20,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[260,2203],[401,2203],[401,2244],[260,2244]],"region":{"top_left_x":259,"top_left_y":2203,"width":142,"height":42},"line":73,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"464e2ea8486f4a80972d6703de2818c3","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"NSAID","text_display":"NSAID","cell_row":21,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,2203],[1299,2203],[1299,2253],[658,2253]],"region":{"top_left_x":658,"top_left_y":2203,"width":642,"height":51},"line":74,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca17abb4b40d4cfead106f96cf775560","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Non-steroidal anti-inflammatory drug","text_display":"Non-steroidal anti-inflammatory drug","cell_row":21,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[260,2294],[336,2294],[336,2335],[260,2335]],"region":{"top_left_x":259,"top_left_y":2294,"width":77,"height":42},"line":75,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b17a30540084364a4b6b63003d5a5fd","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"OA","text_display":"OA","cell_row":22,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,2294],[894,2294],[894,2335],[658,2335]],"region":{"top_left_x":658,"top_left_y":2294,"width":237,"height":42},"line":76,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c79225c1b21d43338e4ff6191fce3c5a","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Osteoarthritis","text_display":"Osteoarthritis","cell_row":22,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,2385],[349,2385],[349,2422],[264,2422]],"region":{"top_left_x":264,"top_left_y":2385,"width":85,"height":38},"line":77,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b8e3b2a31bd4dd488d130c8565f023f","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"OAI","text_display":"OAI","cell_row":23,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[658,2383],[1057,2383],[1057,2424],[658,2424]],"region":{"top_left_x":658,"top_left_y":2383,"width":399,"height":42},"line":78,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8ef5e56655940a7b19505275f8cd701","type":"simple_cell","conversion_output":false,"parent_id":"5d4ae7fd0a464e2c887e1a08fbc5e4eb","text":"Osteoarthritis Initiative","text_display":"Osteoarthritis Initiative","cell_row":23,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":79,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"825956843f7843e4a98a280819555108","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[391,2548],[391,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":148,"height":41},"line":80,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"10bb80ba69634ee590bc13bf5c435ab9","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2527],[1603,2527],[1603,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2526,"width":95,"height":38},"line":81,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f7bb3b8469624ae291b3c335af92b4a0","type":"page_info","conversion_output":false,"text":"14/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-015","page":15,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be41a528bdd240d992e58de1b1bdbd05","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae51a2b3920b46e29334c7ced598d093","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c086977b33ad4624a0a459db4117f149","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[260,320],[1867,320],[1867,2434],[260,2434]],"region":{"top_left_x":259,"top_left_y":320,"width":1608,"height":2115},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1eaccd53667a4216933b8edcb3526b34","type":"table","conversion_output":true,"children_ids":["e323ade3ad804e6db671fd0e64754c62","d97a7f19ef984626ab3c0c10aa9903bc","4a483d6f179a48b49e92fa993c032528","f698088ac1e445fb8f2037ce3c3f9453","8007159ad5e04a7586dccaecdeb38577","abd5fb415f294f76abc9f159d8e2cc79","e69966ec829545788be238546eacf4fd","ff1fdeed76a14b5f8125b5c660d8f4de","78acf91912954b8ab7c270060d78bf07","75875b9dfaa347469f771edc2f339e2d","8ce16daf94cf4d4fadebcd35d3d1d2a1","6adc0794f5a24ad9a7588994c2eff880","78d228633770456895935ad4eab27d7e","b2353a26efaf483ea9dbfbc887c7b66d","6eda49594922499fb1b2d9e0cd47db49","5f1b09003efd4a36b56d70776869f9c4","97daf2900ba8414d9c76de522c2119be","4c1b1a2a2aa44b16acf56f746d60a546","ee48a16897754f99a767626bdae0261b","927965c5e8a648b48800b6cc5a5eb21d","0e9635ec973c47948be1f9ea41f275a7","daea22143193496fae73af08f17cdf31","eea357285a0c47e3ba60cd102d13dac5","1226c811091c4a768884ceeb93b85648","ff59a2f8e0154a3493624272cb5f1e76","c4e5bf05fa484cf89e3afcb198d5fbae","957b713f2bfa435eb4e68947efaeb8c9","d564b3a30f4245b08a02fb4cd182724b","02a1fcdaad7647818ebfe4e7a6ad9b65","0bc9345683734f8bbea314ad89e89167","6d331928bb1d4375b9c94676eabc45d5","bc70ebb629c148719f79c6cda0ceb2f8","8589724af35b4b308490b834c61c49e3","c270407ba36046b29ae88d19e91e5b8c","46d8a4219ed946fca8a32291a658cde5","de4d23f8ae524d97a943c77771779e29","1328a151689e41c5a1f6d511128b1b45","e8e2412801044128b5ec23ae415bcc4d","f73d5e1ff87f4dc8b46655ccf3d4bb89","59bb6d19bb3f42d3aa6ef91a0b5d52b9","22b1be2d85d34cd28843c78995e69232","b7c660d2884b468d89a8a963fc645c44","6fb3a6152aac409aac955591759059df","9ddc815141d2407aaaa90f56c10055b7","e8997bbb7d83402e8725c3e474ac27e5","09a230f8a6524aa087222ee5de13388a","795bb211cf394615a8235e87635edb47","3b9e9332dd634c03a4acde2380c6030c","36236d3e2b8740028ec61b05718b0c9d","3739cfdbcbfd47b0bc2d591b4a166136","5b8e4d417c3f4ebd86ce348b11068abb","00cc2287b31d49448ac9ef29af3e1170","24aad60665f04a8cbf4fa95893de725b","94cdeae910ff463d9e9c46a4859a3ec7","fe6e8ce0f2f446d3bc1a3b65e073e496","e236272ea3244a059a7aa517e95e37f8","2299af79b87d4002a93fc52c9f943e66","4768167c5062480ba6d07d2d507082ab","1a0d688698ba4aac95405d7755bf45df","ab705171051b455e88cf778d4ac7e988","fb5435c09b47417ab72aa7ffcab9950b","96cd960e1d514f378916f906d0e0d94b","149a45a071ee4865834d22a988a1a220","0a420275801c41c6a449203d05877ce9","a357f80d991a49bbb14a8bc597cc13e3","0e13cf4a0d9b467b89df39155e958b5d","44f8ff30e16d47cc88958249f73530e2","b0d158db9acd444b8e89c37e30cd5b7a","0d20b92a59cc48db84dc94ac9642243d","69066c61453b4f28b2e57e2bf2f88379","ad919994e9ce4bd692c8c43647f69804"],"text":"\\begin{tabular}{|l|l|}\n\\hline OARSI & Osteoarthritis Research Society International \\\\\n\\hline OMERACT-OARSI & Outcome Measures in Rheumatology - Osteoarthritis Research Society International (responder criteria) \\\\\n\\hline PD & Pharmacodynamic(s) \\\\\n\\hline PGA & Patient's Global Assessment \\\\\n\\hline PGIC & Patient Global Impression of Change \\\\\n\\hline PGt & Pharmacogenetics \\\\\n\\hline PIINP & II form of the propeptides from the N-terminus processed type II collagen \\\\\n\\hline PIICP & Propeptides from the C-terminus processed type II collagen \\\\\n\\hline PK & Pharmacokinetic(s) \\\\\n\\hline POC & Proof of concept \\\\\n\\hline PP & Per Protocol \\\\\n\\hline PRO & Patient Reported Outcome \\\\\n\\hline QOL & Quality of life \\\\\n\\hline QTc & Corrected electrocardiogram QT interval \\\\\n\\hline RF & Rheumatoid factor \\\\\n\\hline rhFGF-18 & Recombinant human fibroblast growth factor 18 \\\\\n\\hline SAE & Serious Adverse Event \\\\\n\\hline SF & Synovial fluid \\\\\n\\hline SUSAR & Suspected unexpected serious adverse reaction \\\\\n\\hline TNF & Tumor necrosis factor \\\\\n\\hline ULN & Upper limit of normal (range) \\\\\n\\hline VAS & Visual analogue scale \\\\\n\\hline W & Week \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline OARSI & Osteoarthritis Research Society International \\\\\n\\hline OMERACT-OARSI & Outcome Measures in Rheumatology - Osteoarthritis Research Society International (responder criteria) \\\\\n\\hline PD & Pharmacodynamic(s) \\\\\n\\hline PGA & Patient's Global Assessment \\\\\n\\hline PGIC & Patient Global Impression of Change \\\\\n\\hline PGt & Pharmacogenetics \\\\\n\\hline PIINP & II form of the propeptides from the N-terminus processed type II collagen \\\\\n\\hline PIICP & Propeptides from the C-terminus processed type II collagen \\\\\n\\hline PK & Pharmacokinetic(s) \\\\\n\\hline POC & Proof of concept \\\\\n\\hline PP & Per Protocol \\\\\n\\hline PRO & Patient Reported Outcome \\\\\n\\hline QOL & Quality of life \\\\\n\\hline QTc & Corrected electrocardiogram QT interval \\\\\n\\hline RF & Rheumatoid factor \\\\\n\\hline rhFGF-18 & Recombinant human fibroblast growth factor 18 \\\\\n\\hline SAE & Serious Adverse Event \\\\\n\\hline SF & Synovial fluid \\\\\n\\hline SUSAR & Suspected unexpected serious adverse reaction \\\\\n\\hline TNF & Tumor necrosis factor \\\\\n\\hline ULN & Upper limit of normal (range) \\\\\n\\hline VAS & Visual analogue scale \\\\\n\\hline W & Week \\\\\n\\hline\n\\end{tabular}","confidence":0.93994140625,"confidence_rate":0.9999579236165962},{"cnt":[[259,320],[616,320],[616,2434],[259,2434]],"region":{"top_left_x":259,"top_left_y":320,"width":358,"height":2115},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e323ade3ad804e6db671fd0e64754c62","type":"table_column","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[655,320],[1863,320],[1863,2434],[655,2434]],"region":{"top_left_x":654,"top_left_y":320,"width":1210,"height":2115},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d97a7f19ef984626ab3c0c10aa9903bc","type":"table_column","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,320],[1866,320],[1866,375],[259,375]],"region":{"top_left_x":259,"top_left_y":320,"width":1607,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a483d6f179a48b49e92fa993c032528","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,407],[1866,405],[1866,511],[259,514]],"region":{"top_left_x":258,"top_left_y":404,"width":1609,"height":110},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f698088ac1e445fb8f2037ce3c3f9453","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,546],[1863,546],[1863,601],[259,601]],"region":{"top_left_x":259,"top_left_y":546,"width":1605,"height":56},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8007159ad5e04a7586dccaecdeb38577","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,636],[1863,636],[1863,686],[259,686]],"region":{"top_left_x":259,"top_left_y":636,"width":1605,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abd5fb415f294f76abc9f159d8e2cc79","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,727],[1866,727],[1866,781],[259,781]],"region":{"top_left_x":259,"top_left_y":726,"width":1607,"height":56},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e69966ec829545788be238546eacf4fd","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,817],[1863,817],[1863,871],[259,871]],"region":{"top_left_x":259,"top_left_y":816,"width":1605,"height":56},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff1fdeed76a14b5f8125b5c660d8f4de","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,904],[1866,904],[1866,1010],[259,1010]],"region":{"top_left_x":259,"top_left_y":903,"width":1607,"height":108},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78acf91912954b8ab7c270060d78bf07","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1043],[1866,1043],[1866,1098],[259,1098]],"region":{"top_left_x":259,"top_left_y":1043,"width":1607,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75875b9dfaa347469f771edc2f339e2d","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1133],[1866,1133],[1866,1185],[259,1185]],"region":{"top_left_x":259,"top_left_y":1133,"width":1607,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ce16daf94cf4d4fadebcd35d3d1d2a1","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1220],[1866,1220],[1866,1278],[259,1278]],"region":{"top_left_x":259,"top_left_y":1220,"width":1607,"height":58},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6adc0794f5a24ad9a7588994c2eff880","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1310],[1866,1310],[1866,1359],[259,1359]],"region":{"top_left_x":259,"top_left_y":1310,"width":1607,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78d228633770456895935ad4eab27d7e","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1400],[1866,1400],[1866,1458],[259,1458]],"region":{"top_left_x":259,"top_left_y":1400,"width":1607,"height":58},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2353a26efaf483ea9dbfbc887c7b66d","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1488],[1866,1488],[1866,1545],[259,1545]],"region":{"top_left_x":259,"top_left_y":1487,"width":1607,"height":59},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6eda49594922499fb1b2d9e0cd47db49","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1578],[1866,1578],[1866,1635],[259,1635]],"region":{"top_left_x":259,"top_left_y":1577,"width":1607,"height":59},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f1b09003efd4a36b56d70776869f9c4","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1668],[1866,1668],[1866,1720],[259,1720]],"region":{"top_left_x":259,"top_left_y":1667,"width":1607,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97daf2900ba8414d9c76de522c2119be","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1755],[1866,1755],[1866,1815],[259,1815]],"region":{"top_left_x":259,"top_left_y":1755,"width":1607,"height":61},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c1b1a2a2aa44b16acf56f746d60a546","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1848],[1866,1848],[1866,1900],[259,1900]],"region":{"top_left_x":259,"top_left_y":1847,"width":1607,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee48a16897754f99a767626bdae0261b","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,1938],[1866,1938],[1866,1992],[259,1992]],"region":{"top_left_x":259,"top_left_y":1937,"width":1607,"height":56},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"927965c5e8a648b48800b6cc5a5eb21d","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,2028],[1866,2028],[1866,2083],[259,2083]],"region":{"top_left_x":259,"top_left_y":2027,"width":1607,"height":56},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e9635ec973c47948be1f9ea41f275a7","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,2118],[1866,2118],[1866,2167],[259,2167]],"region":{"top_left_x":259,"top_left_y":2117,"width":1607,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"daea22143193496fae73af08f17cdf31","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,2205],[1866,2205],[1866,2260],[259,2260]],"region":{"top_left_x":259,"top_left_y":2205,"width":1607,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eea357285a0c47e3ba60cd102d13dac5","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,2295],[1866,2295],[1866,2353],[259,2353]],"region":{"top_left_x":259,"top_left_y":2295,"width":1607,"height":58},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1226c811091c4a768884ceeb93b85648","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[259,2385],[1866,2385],[1866,2432],[259,2432]],"region":{"top_left_x":259,"top_left_y":2385,"width":1607,"height":47},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff59a2f8e0154a3493624272cb5f1e76","type":"table_row","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"","text_display":""},{"cnt":[[264,325],[395,325],[395,361],[264,361]],"region":{"top_left_x":264,"top_left_y":325,"width":132,"height":36},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4e5bf05fa484cf89e3afcb198d5fbae","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"OARSI","text_display":"OARSI","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,325],[1413,325],[1413,372],[663,372]],"region":{"top_left_x":662,"top_left_y":325,"width":752,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"957b713f2bfa435eb4e68947efaeb8c9","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Osteoarthritis Research Society International","text_display":"Osteoarthritis Research Society International","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,413],[611,413],[611,454],[264,454]],"region":{"top_left_x":264,"top_left_y":412,"width":347,"height":42},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d564b3a30f4245b08a02fb4cd182724b","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"OMERACT-OARSI","text_display":"OMERACT-OARSI","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[657,413],[1861,413],[1861,508],[657,508]],"region":{"top_left_x":657,"top_left_y":412,"width":1204,"height":97},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02a1fcdaad7647818ebfe4e7a6ad9b65","type":"complex_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","children_ids":["3ba1c3de2f1342a68c0bb559733d5819","d2379b2fa56a4420ae19088153ad2331"],"text":"Outcome Measures in Rheumatology - Osteoarthritis Research Society International (responder criteria)","text_display":"Outcome Measures in Rheumatology - Osteoarthritis Research Society International (responder criteria)","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,413],[1858,413],[1858,459],[663,459]],"region":{"top_left_x":662,"top_left_y":412,"width":1196,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ba1c3de2f1342a68c0bb559733d5819","type":"text","conversion_output":false,"parent_id":"02a1fcdaad7647818ebfe4e7a6ad9b65","text":"Outcome Measures in Rheumatology - Osteoarthritis Research Society","text_display":"Outcome Measures in Rheumatology - Osteoarthritis Research Society","confidence":1,"confidence_rate":1},{"cnt":[[663,462],[1208,462],[1208,508],[663,508]],"region":{"top_left_x":662,"top_left_y":461,"width":547,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2379b2fa56a4420ae19088153ad2331","type":"text","conversion_output":false,"parent_id":"02a1fcdaad7647818ebfe4e7a6ad9b65","text":"International (responder criteria)","text_display":" International (responder criteria)","confidence":1,"confidence_rate":1},{"cnt":[[259,541],[330,541],[330,593],[259,593]],"region":{"top_left_x":259,"top_left_y":540,"width":71,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bc9345683734f8bbea314ad89e89167","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"PD","text_display":"PD","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,552],[1020,552],[1020,596],[663,596]],"region":{"top_left_x":662,"top_left_y":551,"width":359,"height":45},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d331928bb1d4375b9c94676eabc45d5","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Pharmacodynamic(s)","text_display":"Pharmacodynamic(s)","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,642],[357,642],[357,680],[264,680]],"region":{"top_left_x":264,"top_left_y":641,"width":94,"height":40},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc70ebb629c148719f79c6cda0ceb2f8","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"PGA","text_display":"PGA","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,642],[1146,642],[1146,677],[663,677]],"region":{"top_left_x":662,"top_left_y":641,"width":484,"height":37},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8589724af35b4b308490b834c61c49e3","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Patient's Global Assessment","text_display":"Patient's Global Assessment","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.93994140625,"confidence_rate":0.9980663176199469},{"cnt":[[264,729],[368,729],[368,770],[264,770]],"region":{"top_left_x":264,"top_left_y":729,"width":105,"height":42},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c270407ba36046b29ae88d19e91e5b8c","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"PGIC","text_display":"PGIC","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,729],[1288,729],[1288,776],[663,776]],"region":{"top_left_x":662,"top_left_y":729,"width":626,"height":47},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46d8a4219ed946fca8a32291a658cde5","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Patient Global Impression of Change","text_display":"Patient Global Impression of Change","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[259,822],[341,822],[341,860],[259,860]],"region":{"top_left_x":259,"top_left_y":822,"width":82,"height":39},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de4d23f8ae524d97a943c77771779e29","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"PGt","text_display":"PGt","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,822],[968,822],[968,868],[663,868]],"region":{"top_left_x":662,"top_left_y":822,"width":307,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1328a151689e41c5a1f6d511128b1b45","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Pharmacogenetics","text_display":"Pharmacogenetics","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,909],[376,909],[376,948],[264,948]],"region":{"top_left_x":264,"top_left_y":909,"width":113,"height":39},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8e2412801044128b5ec23ae415bcc4d","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"PIINP","text_display":"PIINP","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[657,904],[1861,904],[1861,1005],[657,1005]],"region":{"top_left_x":657,"top_left_y":903,"width":1204,"height":102},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f73d5e1ff87f4dc8b46655ccf3d4bb89","type":"complex_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","children_ids":["44af26bb09ce4d54ab9ce37397161ed0","4630cdef2d7d48a1818ed0ee2979945e"],"text":"II form of the propeptides from the N-terminus processed type II collagen","text_display":"II form of the propeptides from the N-terminus processed type II collagen","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,909],[1858,909],[1858,956],[663,956]],"region":{"top_left_x":662,"top_left_y":909,"width":1196,"height":47},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44af26bb09ce4d54ab9ce37397161ed0","type":"text","conversion_output":false,"parent_id":"f73d5e1ff87f4dc8b46655ccf3d4bb89","text":"II form of the propeptides from the N-terminus processed type II","text_display":"II form of the propeptides from the N-terminus processed type II","confidence":1,"confidence_rate":1},{"cnt":[[663,958],[807,958],[807,1005],[663,1005]],"region":{"top_left_x":662,"top_left_y":958,"width":146,"height":47},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4630cdef2d7d48a1818ed0ee2979945e","type":"text","conversion_output":false,"parent_id":"f73d5e1ff87f4dc8b46655ccf3d4bb89","text":"collagen","text_display":" collagen","confidence":1,"confidence_rate":1},{"cnt":[[264,1048],[374,1048],[374,1089],[264,1089]],"region":{"top_left_x":264,"top_left_y":1048,"width":110,"height":42},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59bb6d19bb3f42d3aa6ef91a0b5d52b9","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"PIICP","text_display":"PIICP","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1046],[1659,1046],[1659,1092],[663,1092]],"region":{"top_left_x":662,"top_left_y":1045,"width":997,"height":48},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22b1be2d85d34cd28843c78995e69232","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Propeptides from the C-terminus processed type II collagen","text_display":"Propeptides from the C-terminus processed type II collagen","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[259,1136],[330,1136],[330,1177],[259,1177]],"region":{"top_left_x":259,"top_left_y":1135,"width":71,"height":42},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7c660d2884b468d89a8a963fc645c44","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"PK","text_display":"PK","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1139],[990,1139],[990,1182],[663,1182]],"region":{"top_left_x":662,"top_left_y":1138,"width":329,"height":45},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fb3a6152aac409aac955591759059df","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Pharmacokinetic(s)","text_display":"Pharmacokinetic(s)","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1226],[352,1226],[352,1267],[264,1267]],"region":{"top_left_x":264,"top_left_y":1225,"width":88,"height":42},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ddc815141d2407aaaa90f56c10055b7","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"POC","text_display":"POC","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1226],[944,1226],[944,1272],[663,1272]],"region":{"top_left_x":662,"top_left_y":1225,"width":282,"height":48},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8997bbb7d83402e8725c3e474ac27e5","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Proof of concept","text_display":"Proof of concept","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[259,1310],[319,1310],[319,1357],[259,1357]],"region":{"top_left_x":259,"top_left_y":1310,"width":61,"height":47},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09a230f8a6524aa087222ee5de13388a","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"PP","text_display":"PP","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1319],[873,1319],[873,1354],[663,1354]],"region":{"top_left_x":662,"top_left_y":1318,"width":211,"height":37},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"795bb211cf394615a8235e87635edb47","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Per Protocol","text_display":"Per Protocol","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1406],[352,1406],[352,1444],[264,1444]],"region":{"top_left_x":264,"top_left_y":1405,"width":88,"height":40},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b9e9332dd634c03a4acde2380c6030c","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"PRO","text_display":"PRO","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1406],[1108,1406],[1108,1452],[663,1452]],"region":{"top_left_x":662,"top_left_y":1405,"width":446,"height":48},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36236d3e2b8740028ec61b05718b0c9d","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Patient Reported Outcome","text_display":"Patient Reported Outcome","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1493],[357,1493],[357,1542],[264,1542]],"region":{"top_left_x":264,"top_left_y":1493,"width":94,"height":50},"line":58,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3739cfdbcbfd47b0bc2d591b4a166136","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"QOL","text_display":"QOL","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1493],[903,1493],[903,1540],[663,1540]],"region":{"top_left_x":662,"top_left_y":1493,"width":241,"height":47},"line":59,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b8e4d417c3f4ebd86ce348b11068abb","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Quality of life","text_display":"Quality of life","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1586],[346,1586],[346,1630],[264,1630]],"region":{"top_left_x":264,"top_left_y":1585,"width":83,"height":45},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00cc2287b31d49448ac9ef29af3e1170","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"QTc","text_display":"QTc","cell_row":13,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1586],[1348,1586],[1348,1632],[663,1632]],"region":{"top_left_x":662,"top_left_y":1585,"width":686,"height":48},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24aad60665f04a8cbf4fa95893de725b","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Corrected electrocardiogram QT interval","text_display":"Corrected electrocardiogram QT interval","cell_row":13,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[259,1676],[324,1676],[324,1711],[259,1711]],"region":{"top_left_x":259,"top_left_y":1675,"width":66,"height":37},"line":62,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94cdeae910ff463d9e9c46a4859a3ec7","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"RF","text_display":"RF","cell_row":14,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1676],[982,1676],[982,1711],[663,1711]],"region":{"top_left_x":662,"top_left_y":1675,"width":321,"height":37},"line":63,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe6e8ce0f2f446d3bc1a3b65e073e496","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Rheumatoid factor","text_display":"Rheumatoid factor","cell_row":14,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1766],[436,1766],[436,1801],[264,1801]],"region":{"top_left_x":264,"top_left_y":1766,"width":173,"height":36},"line":64,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e236272ea3244a059a7aa517e95e37f8","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"rhFGF-18","text_display":"rhFGF-18","cell_row":15,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1766],[1468,1766],[1468,1807],[663,1807]],"region":{"top_left_x":662,"top_left_y":1766,"width":806,"height":41},"line":65,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2299af79b87d4002a93fc52c9f943e66","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Recombinant human fibroblast growth factor 18","text_display":"Recombinant human fibroblast growth factor 18","cell_row":15,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1853],[352,1853],[352,1892],[264,1892]],"region":{"top_left_x":264,"top_left_y":1853,"width":88,"height":39},"line":66,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4768167c5062480ba6d07d2d507082ab","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"SAE","text_display":"SAE","cell_row":16,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1853],[1047,1853],[1047,1889],[663,1889]],"region":{"top_left_x":662,"top_left_y":1853,"width":386,"height":36},"line":67,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a0d688698ba4aac95405d7755bf45df","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Serious Adverse Event","text_display":"Serious Adverse Event","cell_row":16,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[259,1946],[319,1946],[319,1992],[259,1992]],"region":{"top_left_x":259,"top_left_y":1946,"width":61,"height":47},"line":68,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab705171051b455e88cf778d4ac7e988","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"SF","text_display":"SF","cell_row":17,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,1946],[906,1946],[906,1987],[663,1987]],"region":{"top_left_x":662,"top_left_y":1946,"width":244,"height":42},"line":69,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb5435c09b47417ab72aa7ffcab9950b","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Synovial fluid","text_display":"Synovial fluid","cell_row":17,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,2033],[404,2033],[404,2069],[264,2069]],"region":{"top_left_x":264,"top_left_y":2033,"width":140,"height":36},"line":70,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96cd960e1d514f378916f906d0e0d94b","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"SUSAR","text_display":"SUSAR","cell_row":18,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,2033],[1446,2033],[1446,2080],[663,2080]],"region":{"top_left_x":662,"top_left_y":2033,"width":784,"height":47},"line":71,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"149a45a071ee4865834d22a988a1a220","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Suspected unexpected serious adverse reaction","text_display":"Suspected unexpected serious adverse reaction","cell_row":18,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,2126],[352,2126],[352,2162],[264,2162]],"region":{"top_left_x":264,"top_left_y":2126,"width":88,"height":36},"line":72,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a420275801c41c6a449203d05877ce9","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"TNF","text_display":"TNF","cell_row":19,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,2123],[1037,2123],[1037,2162],[663,2162]],"region":{"top_left_x":662,"top_left_y":2123,"width":375,"height":39},"line":73,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a357f80d991a49bbb14a8bc597cc13e3","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Tumor necrosis factor","text_display":"Tumor necrosis factor","cell_row":19,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,2213],[357,2213],[357,2252],[264,2252]],"region":{"top_left_x":264,"top_left_y":2213,"width":94,"height":39},"line":74,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e13cf4a0d9b467b89df39155e958b5d","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"ULN","text_display":"ULN","cell_row":20,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,2213],[1162,2213],[1162,2254],[663,2254]],"region":{"top_left_x":662,"top_left_y":2213,"width":501,"height":42},"line":75,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44f8ff30e16d47cc88958249f73530e2","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Upper limit of normal (range)","text_display":"Upper limit of normal (range)","cell_row":20,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,2301],[354,2301],[354,2339],[264,2339]],"region":{"top_left_x":264,"top_left_y":2300,"width":91,"height":39},"line":76,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0d158db9acd444b8e89c37e30cd5b7a","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"VAS","text_display":"VAS","cell_row":21,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,2301],[1031,2301],[1031,2347],[663,2347]],"region":{"top_left_x":662,"top_left_y":2300,"width":370,"height":48},"line":77,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d20b92a59cc48db84dc94ac9642243d","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Visual analogue scale","text_display":"Visual analogue scale","cell_row":21,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[259,2388],[314,2388],[314,2434],[259,2434]],"region":{"top_left_x":259,"top_left_y":2388,"width":55,"height":47},"line":78,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69066c61453b4f28b2e57e2bf2f88379","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"W","text_display":"W","cell_row":22,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[663,2388],[766,2388],[766,2432],[663,2432]],"region":{"top_left_x":662,"top_left_y":2388,"width":105,"height":44},"line":79,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad919994e9ce4bd692c8c43647f69804","type":"simple_cell","conversion_output":false,"parent_id":"1eaccd53667a4216933b8edcb3526b34","text":"Week","text_display":"Week","cell_row":22,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":80,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8c0e6831e77a4983abae9b5f9f069c05","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":81,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"83f29c32b4624a6f87579786c6e97661","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2529],[1605,2529],[1605,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2528,"width":97,"height":36},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"132cd268b18d436891f890b02281284c","type":"page_info","conversion_output":false,"text":"15/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-016","page":16,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"057979a922234006a9b38a425725dd0c","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40a2bc25eea24917837728a2499479d8","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82bc5bd1da694c3ab4c5405f3f5cb016","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[259,319],[445,319],[445,552],[259,552]],"region":{"top_left_x":259,"top_left_y":319,"width":186,"height":233},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"278f7f3fa927420cb91ecc163db86c8e","type":"column","conversion_output":false,"children_ids":["134a1ee2ea1748129fade9ccd43bf4bb","6192d6847a9d426dad58c6f827283ceb","f3589231b02c42a18f4190afa9fbf7a9"],"text":"","text_display":""},{"cnt":[[262,322],[370,322],[370,367],[262,367]],"region":{"top_left_x":262,"top_left_y":322,"width":108,"height":46},"line":5,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"134a1ee2ea1748129fade9ccd43bf4bb","type":"text","conversion_output":true,"parent_id":"278f7f3fa927420cb91ecc163db86c8e","text":"WBC","text_display":"\n\nWBC","confidence":1,"confidence_rate":1},{"cnt":[[262,408],[440,408],[440,458],[262,458]],"region":{"top_left_x":262,"top_left_y":408,"width":179,"height":50},"line":6,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6192d6847a9d426dad58c6f827283ceb","type":"text","conversion_output":true,"parent_id":"278f7f3fa927420cb91ecc163db86c8e","text":"WOMAC","text_display":"\nWOMAC","confidence":1,"confidence_rate":1},{"cnt":[[262,498],[432,498],[432,548],[262,548]],"region":{"top_left_x":262,"top_left_y":498,"width":170,"height":50},"line":7,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3589231b02c42a18f4190afa9fbf7a9","type":"text","conversion_output":true,"parent_id":"278f7f3fa927420cb91ecc163db86c8e","text":"WORMS","text_display":"\nWORMS","confidence":1,"confidence_rate":1},{"cnt":[[654,319],[1760,319],[1760,557],[654,557]],"region":{"top_left_x":654,"top_left_y":319,"width":1106,"height":238},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4430d19de83f40958b2ed582ee5e5126","type":"column","conversion_output":false,"children_ids":["b934b48b41d141169ad451af1c509fcf","5aa837be7118494bad1862ac53a0a5ee","e066692146134361a9fd0d95c5d8d651"],"text":"","text_display":""},{"cnt":[[657,322],[947,322],[947,367],[657,367]],"region":{"top_left_x":657,"top_left_y":322,"width":291,"height":46},"line":9,"column":2,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b934b48b41d141169ad451af1c509fcf","type":"text","conversion_output":true,"parent_id":"4430d19de83f40958b2ed582ee5e5126","text":"White blood cell","text_display":"\n\nWhite blood cell","confidence":1,"confidence_rate":1},{"cnt":[[657,408],[1755,408],[1755,458],[657,458]],"region":{"top_left_x":657,"top_left_y":408,"width":1099,"height":50},"line":10,"column":2,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5aa837be7118494bad1862ac53a0a5ee","type":"text","conversion_output":true,"parent_id":"4430d19de83f40958b2ed582ee5e5126","text":"Western Ontario and McMaster Universities Osteoarthritis Index","text_display":"\nWestern Ontario and McMaster Universities Osteoarthritis Index","confidence":1,"confidence_rate":1},{"cnt":[[657,498],[1515,498],[1515,552],[657,552]],"region":{"top_left_x":657,"top_left_y":498,"width":858,"height":55},"line":11,"column":2,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e066692146134361a9fd0d95c5d8d651","type":"text","conversion_output":true,"parent_id":"4430d19de83f40958b2ed582ee5e5126","text":"Whole Organ Magnetic Resonance Imaging Score","text_display":"\nWhole Organ Magnetic Resonance Imaging Score","confidence":0.99951171875,"confidence_rate":0.9999900326925697},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9ba78503bd3d444497777af66dcad21f","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[442,2543],[449,2545],[453,2550],[455,2560],[455,2567],[451,2573],[446,2575],[328,2584],[247,2584],[244,2582],[244,2545],[249,2543]],"region":{"top_left_x":244,"top_left_y":2543,"width":211,"height":41},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4d732421b96e491bb3681f535fd19a1a","type":"page_info","conversion_output":false,"text":"Object No.CCI","text_display":"","confidence":0.9956102357245982,"confidence_rate":0.9997556172229634},{"cnt":[[1508,2522],[1605,2522],[1605,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2522,"width":97,"height":42},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"83d96037988e4b59828711f1d1e911e4","type":"page_info","conversion_output":false,"text":"16/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-017","page":17,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"768767a27eb84bc583c5f9a099377cee","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da5740b537d74aa99e91a8008eddac38","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f95b21c000b64e228db62b88ebc48559","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,318],[793,318],[793,389],[243,389]],"region":{"top_left_x":242,"top_left_y":317,"width":551,"height":72},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c6510c5476647f69e57855599afd7b7","type":"section_header","conversion_output":false,"children_ids":["7616e5a94fa744a9997ee9abc277351b","2ff69a64a71b4bd089f2596aedbb1892"],"text":"","text_display":""},{"cnt":[[243,327],[279,327],[279,374],[243,374]],"region":{"top_left_x":242,"top_left_y":326,"width":38,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7616e5a94fa744a9997ee9abc277351b","type":"text","conversion_output":true,"parent_id":"7c6510c5476647f69e57855599afd7b7","text":"1","text_display":"\n\n\\section*{1","confidence":0.99560546875,"confidence_rate":0.99560546875},{"cnt":[[593,322],[788,322],[788,382],[593,382]],"region":{"top_left_x":592,"top_left_y":322,"width":197,"height":61},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ff69a64a71b4bd089f2596aedbb1892","type":"text","conversion_output":true,"parent_id":"7c6510c5476647f69e57855599afd7b7","text":"Synopsis","text_display":" Synopsis}","confidence":1,"confidence_rate":1},{"cnt":[[241,415],[1897,415],[1897,2499],[241,2499]],"region":{"top_left_x":240,"top_left_y":414,"width":1658,"height":2085},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74c2c0cee8ec4e02b367d8a22d7ab826","type":"table","conversion_output":true,"children_ids":["85245fa3e27640958056a348dde3811d","fa540bde034a4b1b80b6b637a5b35722","6c47032d8e584f7caf5a4ff2895e8089","13a1df7e44ee4b719e15f53299f0afcd","a1098a526f4c4ce79335a3a3c0c2560d","e4ebb39ac2f242b1aeada884c15bdd0a","34f2103aa08b40e9bb4b0744db9bab4e","26fea4d5ea9944528a3ffdb90167fa98","4e24192dc7284c1ab0deb5b48072c685","a6fdecd67d234f79bd72d50d6d0e8f95","58f790072e144176a15e4847222da9f8","b43a77659ce54d70b4d1ca8b6517df79","64c028dbf2584f46a7a7372600bda43b","3ee27121054f4010b0d2ea63787c5713","d16931cddd8b435f8dbc4c189573e5c5","03e7774a49db4303aea273c8411daeef","611c75b6055546639002612ae3e93480","92969c06f5f341ef9b437670ee6cf749","a0355953518d48c79b51d32274e1dee8","cbd9a173d6f444d5bea9de7a7aa252d1","502d5a724340461aabf594bbbcc3f0fb","a931c2c492c0403ab6ff1ca25aadbc0c","13a540b14d214e769403b9575da0e9eb","c486a941c5b74496856c9cf340bbb02f","03ee87eb88164bcabed931e1b1a81bca","5f796f3d43464a8a9ceb9ca2a335b153","46ce61bf45d54f5fa308e96ed2d41cd9","4ef91dc502394085916df471f7a8e1fe","3efc1fa0019d4390af48324b22170680","f44027b087f74488b30e192d94317865","8d0f3948856c41759d664f4829d65ac0","52782f1efb6147b0ac1c569b1ee5af3c"],"text":"\\begin{tabular}{|l|l|}\n\\hline Trial title & A multicenter, randomized, double-blind, placebocontrolled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD) \\\\\n\\hline Trial number & EMR700692_006 \\\\\n\\hline EudraCT number & 2011-003059-20 \\\\\n\\hline Sponsor & \\begin{tabular}{l}\nMerck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany \\\\\n(for the United States of America) \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370 USA\n\\end{tabular} \\\\\n\\hline Phase & II \\\\\n\\hline Trial under IND & \\begin{tabular}{l}\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-017.jpg?height=56\\&width=58\\&top_left_y=1338\\&top_left_x=881) \\\\\nyes □ no\n\\end{tabular} \\\\\n\\hline FDA \"covered trial\" & □ yes □ no \\\\\n\\hline Trial centers/countries & Approximately 10 to 15 trial sites located in Europe, the United States, and possibly other geographical regions \\\\\n\\hline Planned trial period (first enrollment-last subject out) & Aug 2013 (first subject's first visit) to Aug 2019 (last visit of follow-up phase) \\\\\n\\hline Trial objectives & \\begin{tabular}{l}\nPrimary: \\\\\nTo evaluate structural changes in cartilage thickness in the total femorotibial joint of the target knee in terms of imaging by magnetic resonance imaging (MRI) \\\\\nSecondary: \\\\\n- To evaluate different dose regimens of sprifermin \\\\\n- To evaluate changes in symptoms of osteoarthritis (OA) \\\\\n- To evaluate changes in structure in terms of imaging by X-ray\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Trial title & A multicenter, randomized, double-blind, placebocontrolled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD) \\\\\n\\hline Trial number & EMR700692_006 \\\\\n\\hline EudraCT number & 2011-003059-20 \\\\\n\\hline Sponsor & \\begin{tabular}{l}\nMerck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany \\\\\n(for the United States of America) \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370 USA\n\\end{tabular} \\\\\n\\hline Phase & II \\\\\n\\hline Trial under IND & \\begin{tabular}{l}\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-017.jpg?height=56\\&width=58\\&top_left_y=1338\\&top_left_x=881) \\\\\nyes □ no\n\\end{tabular} \\\\\n\\hline FDA \"covered trial\" & □ yes □ no \\\\\n\\hline Trial centers/countries & Approximately 10 to 15 trial sites located in Europe, the United States, and possibly other geographical regions \\\\\n\\hline Planned trial period (first enrollment-last subject out) & Aug 2013 (first subject's first visit) to Aug 2019 (last visit of follow-up phase) \\\\\n\\hline Trial objectives & \\begin{tabular}{l}\nPrimary: \\\\\nTo evaluate structural changes in cartilage thickness in the total femorotibial joint of the target knee in terms of imaging by magnetic resonance imaging (MRI) \\\\\nSecondary: \\\\\n- To evaluate different dose regimens of sprifermin \\\\\n- To evaluate changes in symptoms of osteoarthritis (OA) \\\\\n- To evaluate changes in structure in terms of imaging by X-ray\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.8975107669830322,"confidence_rate":0.9999817269266704},{"cnt":[[251,414],[794,414],[794,2496],[251,2496]],"region":{"top_left_x":250,"top_left_y":414,"width":544,"height":2082},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85245fa3e27640958056a348dde3811d","type":"table_column","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[876,414],[1891,414],[1891,2501],[876,2501]],"region":{"top_left_x":875,"top_left_y":414,"width":1016,"height":2088},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa540bde034a4b1b80b6b637a5b35722","type":"table_column","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,441],[1893,441],[1893,711],[240,711]],"region":{"top_left_x":240,"top_left_y":441,"width":1654,"height":271},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c47032d8e584f7caf5a4ff2895e8089","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,741],[1893,741],[1893,796],[240,796]],"region":{"top_left_x":240,"top_left_y":741,"width":1654,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13a1df7e44ee4b719e15f53299f0afcd","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,831],[1893,831],[1893,886],[240,886]],"region":{"top_left_x":240,"top_left_y":831,"width":1654,"height":56},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1098a526f4c4ce79335a3a3c0c2560d","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,916],[1893,916],[1893,1224],[240,1224]],"region":{"top_left_x":240,"top_left_y":916,"width":1654,"height":309},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4ebb39ac2f242b1aeada884c15bdd0a","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,1243],[1893,1243],[1893,1303],[240,1303]],"region":{"top_left_x":240,"top_left_y":1243,"width":1654,"height":61},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34f2103aa08b40e9bb4b0744db9bab4e","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,1332],[1896,1328],[1896,1399],[240,1404]],"region":{"top_left_x":239,"top_left_y":1327,"width":1658,"height":77},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26fea4d5ea9944528a3ffdb90167fa98","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,1418],[1896,1418],[1896,1497],[240,1497]],"region":{"top_left_x":240,"top_left_y":1418,"width":1657,"height":80},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e24192dc7284c1ab0deb5b48072c685","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,1514],[1896,1514],[1896,1634],[240,1634]],"region":{"top_left_x":240,"top_left_y":1513,"width":1657,"height":121},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6fdecd67d234f79bd72d50d6d0e8f95","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,1650],[1896,1650],[1896,1822],[240,1822]],"region":{"top_left_x":240,"top_left_y":1649,"width":1657,"height":173},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58f790072e144176a15e4847222da9f8","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[240,1838],[1896,1838],[1896,2496],[240,2496]],"region":{"top_left_x":240,"top_left_y":1838,"width":1657,"height":658},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b43a77659ce54d70b4d1ca8b6517df79","type":"table_row","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"","text_display":""},{"cnt":[[262,463],[445,463],[445,509],[262,509]],"region":{"top_left_x":261,"top_left_y":463,"width":184,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64c028dbf2584f46a7a7372600bda43b","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"Trial title","text_display":"Trial title","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[881,460],[1874,460],[1874,709],[881,709]],"region":{"top_left_x":881,"top_left_y":460,"width":994,"height":249},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ee27121054f4010b0d2ea63787c5713","type":"complex_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","children_ids":["23ea7f6f057c4197932701adb69c1016","8256135bb45a453c993bf2aa72d625cb","d8f200108310487cb67f600da1651167","fa69760e313844dda5847113cf6274b8","55bc4144746643538844cd0aade71cd9"],"text":"A multicenter, randomized, double-blind, placebocontrolled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD)","text_display":"A multicenter, randomized, double-blind, placebocontrolled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[887,463],[1863,463],[1863,515],[887,515]],"region":{"top_left_x":886,"top_left_y":463,"width":978,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23ea7f6f057c4197932701adb69c1016","type":"text","conversion_output":false,"parent_id":"3ee27121054f4010b0d2ea63787c5713","text":"A multicenter, randomized, double-blind, placebo-","text_display":"A multicenter, randomized, double-blind, placebo","confidence":1,"confidence_rate":1},{"cnt":[[889,512],[1866,512],[1866,561],[889,561]],"region":{"top_left_x":889,"top_left_y":512,"width":978,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8256135bb45a453c993bf2aa72d625cb","type":"text","conversion_output":false,"parent_id":"3ee27121054f4010b0d2ea63787c5713","text":"controlled, parallel-group trial to investigate the efficacy","text_display":"controlled, parallel-group trial to investigate the efficacy","confidence":1,"confidence_rate":1},{"cnt":[[889,561],[1869,561],[1869,608],[889,608]],"region":{"top_left_x":889,"top_left_y":561,"width":980,"height":47},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8f200108310487cb67f600da1651167","type":"text","conversion_output":false,"parent_id":"3ee27121054f4010b0d2ea63787c5713","text":"and safety of different intra-articular (i.a.) dosages of","text_display":" and safety of different intra-articular (i.a.) dosages of","confidence":1,"confidence_rate":1},{"cnt":[[889,605],[1866,605],[1866,657],[889,657]],"region":{"top_left_x":889,"top_left_y":604,"width":978,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa69760e313844dda5847113cf6274b8","type":"text","conversion_output":false,"parent_id":"3ee27121054f4010b0d2ea63787c5713","text":"sprifermin in subjects with primary osteoarthritis of the","text_display":" sprifermin in subjects with primary osteoarthritis of the","confidence":1,"confidence_rate":1},{"cnt":[[889,657],[1219,657],[1219,706],[889,706]],"region":{"top_left_x":889,"top_left_y":656,"width":331,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55bc4144746643538844cd0aade71cd9","type":"text","conversion_output":false,"parent_id":"3ee27121054f4010b0d2ea63787c5713","text":"knee (FORWARD)","text_display":" knee (FORWARD)","confidence":1,"confidence_rate":1},{"cnt":[[262,747],[516,747],[516,791],[262,791]],"region":{"top_left_x":261,"top_left_y":746,"width":255,"height":45},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d16931cddd8b435f8dbc4c189573e5c5","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"Trial number","text_display":"Trial number","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[887,747],[1192,747],[1192,793],[887,793]],"region":{"top_left_x":886,"top_left_y":746,"width":307,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03e7774a49db4303aea273c8411daeef","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"EMR700692_006","text_display":"EMR700692_006","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[262,840],[597,840],[597,881],[262,881]],"region":{"top_left_x":261,"top_left_y":839,"width":337,"height":42},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"611c75b6055546639002612ae3e93480","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"EudraCT number","text_display":"EudraCT number","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[884,840],[1176,840],[1176,881],[884,881]],"region":{"top_left_x":883,"top_left_y":839,"width":293,"height":42},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92969c06f5f341ef9b437670ee6cf749","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"2011-003059-20","text_display":"2011-003059-20","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[262,932],[420,932],[420,979],[262,979]],"region":{"top_left_x":261,"top_left_y":932,"width":160,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0355953518d48c79b51d32274e1dee8","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"Sponsor","text_display":"Sponsor","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[881,921],[1866,921],[1866,1216],[881,1216]],"region":{"top_left_x":881,"top_left_y":921,"width":986,"height":296},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbd9a173d6f444d5bea9de7a7aa252d1","type":"complex_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","children_ids":["ee7e7c0186074c339f92db559a1ce3ce","2bd7450a089a4f3e8a990e421eb91ef4","88969b94bf7f454ba91802bfdc86df43","7dcd353d8a1246d9aa69757edbbfe0ad","0825f5d70aa24d49a0623d3a36f5182f"],"text":"\\begin{tabular}{l}\nMerck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany \\\\\n(for the United States of America) \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370 USA\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nMerck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany \\\\\n(for the United States of America) \\\\\nEMD Serono, Inc. \\\\\nOne Technology Place, Rockland, MA 02370 USA\n\\end{tabular}","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.8975107669830322,"confidence_rate":0.9996455377151191},{"cnt":[[887,927],[1858,927],[1858,979],[887,979]],"region":{"top_left_x":886,"top_left_y":926,"width":972,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee7e7c0186074c339f92db559a1ce3ce","type":"text","conversion_output":false,"parent_id":"cbd9a173d6f444d5bea9de7a7aa252d1","text":"Merck KGaA, Frankfurter Strasse 250, 64293 Darmstadt,","text_display":"Merck KGaA, Frankfurter Strasse 250, 64293 Darmstadt,","confidence":0.8975107669830322,"confidence_rate":0.9982289445654295},{"cnt":[[889,976],[1050,976],[1050,1028],[889,1028]],"region":{"top_left_x":889,"top_left_y":976,"width":162,"height":52},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bd7450a089a4f3e8a990e421eb91ef4","type":"text","conversion_output":false,"parent_id":"cbd9a173d6f444d5bea9de7a7aa252d1","text":"Germany","text_display":" Germany","confidence":1,"confidence_rate":1},{"cnt":[[889,1063],[1460,1063],[1460,1115],[889,1115]],"region":{"top_left_x":889,"top_left_y":1063,"width":571,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88969b94bf7f454ba91802bfdc86df43","type":"text","conversion_output":false,"parent_id":"cbd9a173d6f444d5bea9de7a7aa252d1","text":"(for the United States of America)","text_display":"\n(for the United States of America)","confidence":1,"confidence_rate":1},{"cnt":[[889,1115],[1203,1115],[1203,1164],[889,1164]],"region":{"top_left_x":889,"top_left_y":1115,"width":315,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dcd353d8a1246d9aa69757edbbfe0ad","type":"text","conversion_output":false,"parent_id":"cbd9a173d6f444d5bea9de7a7aa252d1","text":"EMD Serono, Inc.","text_display":"\nEMD Serono, Inc.","confidence":1,"confidence_rate":1},{"cnt":[[887,1162],[1754,1162],[1754,1213],[887,1213]],"region":{"top_left_x":886,"top_left_y":1161,"width":869,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0825f5d70aa24d49a0623d3a36f5182f","type":"text","conversion_output":false,"parent_id":"cbd9a173d6f444d5bea9de7a7aa252d1","text":"One Technology Place, Rockland, MA 02370 USA","text_display":"\nOne Technology Place, Rockland, MA 02370 USA","confidence":1,"confidence_rate":1},{"cnt":[[265,1254],[379,1254],[379,1295],[265,1295]],"region":{"top_left_x":264,"top_left_y":1254,"width":116,"height":42},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"502d5a724340461aabf594bbbcc3f0fb","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"Phase","text_display":"Phase","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[881,1252],[928,1252],[928,1298],[881,1298]],"region":{"top_left_x":881,"top_left_y":1251,"width":47,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a931c2c492c0403ab6ff1ca25aadbc0c","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"II","text_display":"II","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[262,1347],[570,1347],[570,1388],[262,1388]],"region":{"top_left_x":261,"top_left_y":1347,"width":310,"height":42},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13a540b14d214e769403b9575da0e9eb","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"Trial under IND","text_display":"Trial under IND","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[884,1336],[1121,1336],[1121,1393],[884,1393]],"region":{"top_left_x":883,"top_left_y":1336,"width":239,"height":58},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c486a941c5b74496856c9cf340bbb02f","type":"complex_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","children_ids":["092842c6694f47529d78b59cd9faa492","0d34d71d740246b8a0a0206e12998a69","d8b917bf9d574363ad26e9027a7f8d6b","ce4b06eac7f84e9e868b6d42464f35d8"],"text":"\\begin{tabular}{l}\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-017.jpg?height=56\\&width=58\\&top_left_y=1338\\&top_left_x=881) \\\\\nyes □ no\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-017.jpg?height=56\\&width=58\\&top_left_y=1338\\&top_left_x=881) \\\\\nyes □ no\n\\end{tabular}","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[881,1339],[938,1339],[938,1393],[881,1393]],"region":{"top_left_x":881,"top_left_y":1338,"width":58,"height":56},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"092842c6694f47529d78b59cd9faa492","type":"diagram","conversion_output":false,"parent_id":"c486a941c5b74496856c9cf340bbb02f","text":"","text_display":"![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-017.jpg?height=56\\&width=58\\&top_left_y=1338\\&top_left_x=881)"},{"cnt":[[944,1342],[1009,1342],[1009,1396],[944,1396]],"region":{"top_left_x":943,"top_left_y":1341,"width":67,"height":56},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d34d71d740246b8a0a0206e12998a69","type":"text","conversion_output":false,"parent_id":"c486a941c5b74496856c9cf340bbb02f","text":"yes","text_display":"\nyes","confidence":1,"confidence_rate":1},{"cnt":[[1012,1339],[1064,1339],[1064,1396],[1012,1396]],"region":{"top_left_x":1012,"top_left_y":1338,"width":52,"height":59},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8b917bf9d574363ad26e9027a7f8d6b","type":"form_field","conversion_output":false,"parent_id":"c486a941c5b74496856c9cf340bbb02f","text":"","text_display":" □","subtype":"box"},{"cnt":[[1069,1339],[1121,1339],[1121,1391],[1069,1391]],"region":{"top_left_x":1069,"top_left_y":1338,"width":53,"height":53},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce4b06eac7f84e9e868b6d42464f35d8","type":"text","conversion_output":false,"parent_id":"c486a941c5b74496856c9cf340bbb02f","text":"no","text_display":" no","confidence":1,"confidence_rate":1},{"cnt":[[265,1434],[636,1434],[636,1481],[265,1481]],"region":{"top_left_x":264,"top_left_y":1434,"width":372,"height":47},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03ee87eb88164bcabed931e1b1a81bca","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"FDA \"covered trial\"","text_display":"FDA \"covered trial\"","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[884,1429],[1121,1429],[1121,1486],[884,1486]],"region":{"top_left_x":883,"top_left_y":1428,"width":239,"height":59},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f796f3d43464a8a9ceb9ca2a335b153","type":"complex_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","children_ids":["491c4387c4d94b77b5b4d974d9e942bd","69cbd3e58a6a4d58abab8d68305406aa","2d60ca1a13a64b768aa36d58d11f011c","73babbc6f09a4262b22ef70f99bf4ff6"],"text":"□ yes □ no","text_display":"□ yes □ no","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[881,1426],[949,1426],[949,1484],[881,1484]],"region":{"top_left_x":881,"top_left_y":1426,"width":69,"height":58},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"491c4387c4d94b77b5b4d974d9e942bd","type":"form_field","conversion_output":false,"parent_id":"5f796f3d43464a8a9ceb9ca2a335b153","text":"","text_display":"□","subtype":"box"},{"cnt":[[947,1443],[1012,1443],[1012,1492],[947,1492]],"region":{"top_left_x":946,"top_left_y":1442,"width":67,"height":50},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69cbd3e58a6a4d58abab8d68305406aa","type":"text","conversion_output":false,"parent_id":"5f796f3d43464a8a9ceb9ca2a335b153","text":"yes","text_display":" yes","confidence":1,"confidence_rate":1},{"cnt":[[1012,1429],[1064,1429],[1064,1484],[1012,1484]],"region":{"top_left_x":1012,"top_left_y":1428,"width":52,"height":56},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d60ca1a13a64b768aa36d58d11f011c","type":"form_field","conversion_output":false,"parent_id":"5f796f3d43464a8a9ceb9ca2a335b153","text":"","text_display":" □","subtype":"box"},{"cnt":[[1069,1445],[1121,1445],[1121,1484],[1069,1484]],"region":{"top_left_x":1069,"top_left_y":1445,"width":53,"height":39},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73babbc6f09a4262b22ef70f99bf4ff6","type":"text","conversion_output":false,"parent_id":"5f796f3d43464a8a9ceb9ca2a335b153","text":"no","text_display":" no","confidence":1,"confidence_rate":1},{"cnt":[[262,1530],[679,1530],[679,1574],[262,1574]],"region":{"top_left_x":261,"top_left_y":1529,"width":419,"height":45},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46ce61bf45d54f5fa308e96ed2d41cd9","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"Trial centers/countries","text_display":"Trial centers/countries","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[881,1522],[1869,1522],[1869,1628],[881,1628]],"region":{"top_left_x":881,"top_left_y":1521,"width":988,"height":108},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ef91dc502394085916df471f7a8e1fe","type":"complex_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","children_ids":["8f92e23b3f674ed787e7611ef37f7276","561337fde2d04c819f406d56a6ca4628"],"text":"Approximately 10 to 15 trial sites located in Europe, the United States, and possibly other geographical regions","text_display":"Approximately 10 to 15 trial sites located in Europe, the United States, and possibly other geographical regions","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[887,1527],[1863,1527],[1863,1579],[887,1579]],"region":{"top_left_x":886,"top_left_y":1527,"width":978,"height":53},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f92e23b3f674ed787e7611ef37f7276","type":"text","conversion_output":false,"parent_id":"4ef91dc502394085916df471f7a8e1fe","text":"Approximately 10 to 15 trial sites located in Europe, the","text_display":"Approximately 10 to 15 trial sites located in Europe, the","confidence":1,"confidence_rate":1},{"cnt":[[887,1576],[1803,1576],[1803,1628],[887,1628]],"region":{"top_left_x":886,"top_left_y":1576,"width":918,"height":53},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"561337fde2d04c819f406d56a6ca4628","type":"text","conversion_output":false,"parent_id":"4ef91dc502394085916df471f7a8e1fe","text":"United States, and possibly other geographical regions","text_display":" United States, and possibly other geographical regions","confidence":1,"confidence_rate":1},{"cnt":[[262,1664],[783,1664],[783,1814],[262,1814]],"region":{"top_left_x":261,"top_left_y":1663,"width":522,"height":151},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3efc1fa0019d4390af48324b22170680","type":"complex_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","children_ids":["cdb29d532eb241aba8a701a862b9c018","e0950803965547da9c92a6714fed4027","a1723ffbe9c94410af325bacd2ad7a35"],"text":"Planned trial period (first enrollment-last subject out)","text_display":"Planned trial period (first enrollment-last subject out)","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[262,1669],[630,1669],[630,1715],[262,1715]],"region":{"top_left_x":261,"top_left_y":1669,"width":370,"height":47},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdb29d532eb241aba8a701a862b9c018","type":"text","conversion_output":false,"parent_id":"3efc1fa0019d4390af48324b22170680","text":"Planned trial period","text_display":"Planned trial period","confidence":1,"confidence_rate":1},{"cnt":[[262,1718],[780,1718],[780,1765],[262,1765]],"region":{"top_left_x":261,"top_left_y":1718,"width":520,"height":47},"line":58,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0950803965547da9c92a6714fed4027","type":"text","conversion_output":false,"parent_id":"3efc1fa0019d4390af48324b22170680","text":"(first enrollment-last subject","text_display":" (first enrollment-last subject","confidence":1,"confidence_rate":1},{"cnt":[[262,1767],[344,1767],[344,1816],[262,1816]],"region":{"top_left_x":261,"top_left_y":1767,"width":83,"height":50},"line":59,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1723ffbe9c94410af325bacd2ad7a35","type":"text","conversion_output":false,"parent_id":"3efc1fa0019d4390af48324b22170680","text":"out)","text_display":" out)","confidence":1,"confidence_rate":1},{"cnt":[[884,1664],[1869,1664],[1869,1770],[884,1770]],"region":{"top_left_x":883,"top_left_y":1663,"width":986,"height":107},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f44027b087f74488b30e192d94317865","type":"complex_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","children_ids":["e0ddbd2877a5400387785960457a720e","49e1cd17ac2544878dd1bdd58339c96d"],"text":"Aug 2013 (first subject's first visit) to Aug 2019 (last visit of follow-up phase)","text_display":"Aug 2013 (first subject's first visit) to Aug 2019 (last visit of follow-up phase)","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9999890603756404},{"cnt":[[887,1669],[1866,1669],[1866,1715],[887,1715]],"region":{"top_left_x":886,"top_left_y":1669,"width":981,"height":47},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0ddbd2877a5400387785960457a720e","type":"text","conversion_output":false,"parent_id":"f44027b087f74488b30e192d94317865","text":"Aug 2013 (first subject's first visit) to Aug 2019 (last","text_display":"Aug 2013 (first subject's first visit) to Aug 2019 (last","confidence":0.99853515625,"confidence_rate":0.9999781208709562},{"cnt":[[889,1715],[1307,1715],[1307,1765],[889,1765]],"region":{"top_left_x":889,"top_left_y":1715,"width":418,"height":50},"line":62,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49e1cd17ac2544878dd1bdd58339c96d","type":"text","conversion_output":false,"parent_id":"f44027b087f74488b30e192d94317865","text":"visit of follow-up phase)","text_display":" visit of follow-up phase)","confidence":1,"confidence_rate":1},{"cnt":[[262,1855],[548,1855],[548,1906],[262,1906]],"region":{"top_left_x":261,"top_left_y":1854,"width":288,"height":53},"line":63,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d0f3948856c41759d664f4829d65ac0","type":"simple_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","text":"Trial objectives","text_display":"Trial objectives","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[878,1849],[1872,1849],[1872,2493],[878,2493]],"region":{"top_left_x":878,"top_left_y":1849,"width":994,"height":644},"line":64,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52782f1efb6147b0ac1c569b1ee5af3c","type":"complex_cell","conversion_output":false,"parent_id":"74c2c0cee8ec4e02b367d8a22d7ab826","children_ids":["897c537a793344fdafc23924adcc2ba1","d9a1d494b7f04e6c90f1a708e6aea113","b2ee25b8b92d47fab715a3542c1d63d2","26088aea750e4716a0b62daa0dad2974","0cb8bf0f22034d2482202f444476ee48","88b65237e49f4a7f9c2f7e81c8fc38ab","ed2bc98f171544f38f7870513aafdfb2","3008f9d5f883460c86cc0c815c9b177a","85bcc282cc1543f9b27c714c1e8e8d0b","55973933d9f346b98543fa7c2034f613"],"text":"\\begin{tabular}{l}\nPrimary: \\\\\nTo evaluate structural changes in cartilage thickness in the total femorotibial joint of the target knee in terms of imaging by magnetic resonance imaging (MRI) \\\\\nSecondary: \\\\\n- To evaluate different dose regimens of sprifermin \\\\\n- To evaluate changes in symptoms of osteoarthritis (OA) \\\\\n- To evaluate changes in structure in terms of imaging by X-ray\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nPrimary: \\\\\nTo evaluate structural changes in cartilage thickness in the total femorotibial joint of the target knee in terms of imaging by magnetic resonance imaging (MRI) \\\\\nSecondary: \\\\\n- To evaluate different dose regimens of sprifermin \\\\\n- To evaluate changes in symptoms of osteoarthritis (OA) \\\\\n- To evaluate changes in structure in terms of imaging by X-ray\n\\end{tabular}","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[889,1855],[1056,1855],[1056,1906],[889,1906]],"region":{"top_left_x":889,"top_left_y":1854,"width":167,"height":53},"line":65,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"897c537a793344fdafc23924adcc2ba1","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"Primary:","text_display":"Primary:","confidence":1,"confidence_rate":1},{"cnt":[[887,1945],[1869,1945],[1869,1994],[887,1994]],"region":{"top_left_x":886,"top_left_y":1944,"width":983,"height":50},"line":66,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9a1d494b7f04e6c90f1a708e6aea113","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"To evaluate structural changes in cartilage thickness in","text_display":"\nTo evaluate structural changes in cartilage thickness in","confidence":1,"confidence_rate":1},{"cnt":[[887,1991],[1869,1991],[1869,2043],[887,2043]],"region":{"top_left_x":886,"top_left_y":1990,"width":983,"height":53},"line":67,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2ee25b8b92d47fab715a3542c1d63d2","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"the total femorotibial joint of the target knee in terms of","text_display":" the total femorotibial joint of the target knee in terms of","confidence":1,"confidence_rate":1},{"cnt":[[887,2040],[1689,2040],[1689,2092],[887,2092]],"region":{"top_left_x":886,"top_left_y":2040,"width":803,"height":52},"line":68,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26088aea750e4716a0b62daa0dad2974","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"imaging by magnetic resonance imaging (MRI)","text_display":" imaging by magnetic resonance imaging (MRI)","confidence":1,"confidence_rate":1},{"cnt":[[887,2130],[1094,2130],[1094,2179],[887,2179]],"region":{"top_left_x":886,"top_left_y":2130,"width":208,"height":50},"line":69,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cb8bf0f22034d2482202f444476ee48","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"Secondary:","text_display":"\nSecondary:","confidence":1,"confidence_rate":1},{"cnt":[[889,2250],[889,2198],[1773,2201],[1773,2253]],"region":{"top_left_x":889,"top_left_y":2198,"width":885,"height":55},"line":70,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88b65237e49f4a7f9c2f7e81c8fc38ab","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"- To evaluate different dose regimens of sprifermin","text_display":"\n- To evaluate different dose regimens of sprifermin","confidence":1,"confidence_rate":1},{"cnt":[[889,2275],[1863,2275],[1863,2321],[889,2321]],"region":{"top_left_x":889,"top_left_y":2274,"width":975,"height":48},"line":71,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed2bc98f171544f38f7870513aafdfb2","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"- To evaluate changes in symptoms of osteoarthritis","text_display":"\n- To evaluate changes in symptoms of osteoarthritis","confidence":1,"confidence_rate":1},{"cnt":[[938,2324],[1037,2324],[1037,2373],[938,2373]],"region":{"top_left_x":938,"top_left_y":2323,"width":99,"height":50},"line":72,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3008f9d5f883460c86cc0c815c9b177a","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"(OA)","text_display":" (OA)","confidence":1,"confidence_rate":1},{"cnt":[[889,2395],[1866,2395],[1866,2441],[889,2441]],"region":{"top_left_x":889,"top_left_y":2394,"width":978,"height":48},"line":73,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85bcc282cc1543f9b27c714c1e8e8d0b","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"- To evaluate changes in structure in terms of imaging","text_display":"\n- To evaluate changes in structure in terms of imaging","confidence":1,"confidence_rate":1},{"cnt":[[933,2438],[1094,2438],[1094,2490],[933,2490]],"region":{"top_left_x":932,"top_left_y":2438,"width":162,"height":53},"line":74,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55973933d9f346b98543fa7c2034f613","type":"text","conversion_output":false,"parent_id":"52782f1efb6147b0ac1c569b1ee5af3c","text":"by X-ray","text_display":" by X-ray","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":75,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a954fbbb022e4d959dbfae8c7c996651","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":76,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f3c05d8b901549aa8e63cdcf42482942","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2529],[1601,2529],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2528,"width":93,"height":36},"line":77,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"608fa1291d524995b1ff22dd652e056e","type":"page_info","conversion_output":false,"text":"17/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-018","page":18,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e043b527a811432fbd681cd7cc97f8d7","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ef55928176943ef962fe52f92b9c8e9","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1595770fbd7844a1a4e33a751d84a982","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,277],[1886,277],[1886,2494],[241,2494]],"region":{"top_left_x":240,"top_left_y":277,"width":1647,"height":2218},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5a4bd336a124a87bf2ab6c4cb0672df","type":"table","conversion_output":true,"children_ids":["1c9c6c9be5a747fe94110a3575093809","10195518afd54ed99aadc507ba600c0c","752f097b83834ed78cac5c92ce9a12b1","0da0fe67933b4094bd8181b21f4bb8b4","5df0533d1e694656ac3721e68d3b9004","d113061f597b451fa8d64860c7cafaec","9076492bd4b44bb186b6b6b0e58d1202"],"text":"\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\n- To evaluate other changes in cartilage morphology in terms of imaging by MRI (sub-regions) \\\\\n- To evaluate changes in physical functioning \\\\\n- To evaluate the safety of sprifermin \\\\\n- To evaluate the pharmacokinetics (PK) of sprifermin in serum and in synovial fluid following i.a. injection \\\\\nExploratory: \\\\\n- To evaluate responder criteria in symptoms \\\\\n- To explore treatment effect on OA pain and other patient-reported outcomes (PROs) \\\\\n- To evaluate changes in quality of life (QOL) \\\\\n- To explore treatment effect on the knee joint and bone structures by MRI \\\\\n- To evaluate long-term treatment effects \\\\\n- To explore the relationship between the change over time in synovial, serum, and urine biomarkers (e.g., cartilage and bone tissue turnover markers, inflammation markers) and the response to the drug \\\\\n- To evaluate potential associations of biomarkers (e.g., genetic variations or protein biomarkers measured at baseline) with drug response, and/or disease severity or disease progression \\\\\n- To explore the relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a function of time, by means of modeling\n\\end{tabular} \\\\\n\\hline Trial design and plan & \\begin{tabular}{l}\nThe trial consists of a screening period, a double-blind placebo-controlled (DBPC) treatment phase, and an extended follow-up phase. \\\\\nSubject eligibility for the trial will be determined during the screening period based on clinical and radiographic criteria, in addition to responses to pain questionnaires after withdrawal of analgesic medications. \\\\\nIn the 2 -year DBPC treatment phase, subjects will be randomized in equal allocation to one of 5 treatment groups (see below). \\\\\nAll subjects will receive 4 cycles of treatment with the Investigational Medicinal Product (IMP; sprifermin or\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\n- To evaluate other changes in cartilage morphology in terms of imaging by MRI (sub-regions) \\\\\n- To evaluate changes in physical functioning \\\\\n- To evaluate the safety of sprifermin \\\\\n- To evaluate the pharmacokinetics (PK) of sprifermin in serum and in synovial fluid following i.a. injection \\\\\nExploratory: \\\\\n- To evaluate responder criteria in symptoms \\\\\n- To explore treatment effect on OA pain and other patient-reported outcomes (PROs) \\\\\n- To evaluate changes in quality of life (QOL) \\\\\n- To explore treatment effect on the knee joint and bone structures by MRI \\\\\n- To evaluate long-term treatment effects \\\\\n- To explore the relationship between the change over time in synovial, serum, and urine biomarkers (e.g., cartilage and bone tissue turnover markers, inflammation markers) and the response to the drug \\\\\n- To evaluate potential associations of biomarkers (e.g., genetic variations or protein biomarkers measured at baseline) with drug response, and/or disease severity or disease progression \\\\\n- To explore the relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a function of time, by means of modeling\n\\end{tabular} \\\\\n\\hline Trial design and plan & \\begin{tabular}{l}\nThe trial consists of a screening period, a double-blind placebo-controlled (DBPC) treatment phase, and an extended follow-up phase. \\\\\nSubject eligibility for the trial will be determined during the screening period based on clinical and radiographic criteria, in addition to responses to pain questionnaires after withdrawal of analgesic medications. \\\\\nIn the 2 -year DBPC treatment phase, subjects will be randomized in equal allocation to one of 5 treatment groups (see below). \\\\\nAll subjects will receive 4 cycles of treatment with the Investigational Medicinal Product (IMP; sprifermin or\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.9253292083740234,"confidence_rate":0.9999639483610534},{"cnt":[[262,277],[660,277],[660,2495],[262,2495]],"region":{"top_left_x":261,"top_left_y":277,"width":400,"height":2219},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c9c6c9be5a747fe94110a3575093809","type":"table_column","conversion_output":false,"parent_id":"d5a4bd336a124a87bf2ab6c4cb0672df","text":"","text_display":""},{"cnt":[[881,277],[1882,277],[1882,2495],[881,2495]],"region":{"top_left_x":881,"top_left_y":277,"width":1002,"height":2219},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10195518afd54ed99aadc507ba600c0c","type":"table_column","conversion_output":false,"parent_id":"d5a4bd336a124a87bf2ab6c4cb0672df","text":"","text_display":""},{"cnt":[[240,288],[1888,288],[1888,1816],[240,1816]],"region":{"top_left_x":240,"top_left_y":287,"width":1648,"height":1529},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"752f097b83834ed78cac5c92ce9a12b1","type":"table_row","conversion_output":false,"parent_id":"d5a4bd336a124a87bf2ab6c4cb0672df","text":"","text_display":""},{"cnt":[[240,1840],[1888,1840],[1888,2492],[240,2492]],"region":{"top_left_x":240,"top_left_y":1840,"width":1648,"height":653},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0da0fe67933b4094bd8181b21f4bb8b4","type":"table_row","conversion_output":false,"parent_id":"d5a4bd336a124a87bf2ab6c4cb0672df","text":"","text_display":""},{"cnt":[[884,302],[1872,302],[1872,1808],[884,1808]],"region":{"top_left_x":883,"top_left_y":301,"width":989,"height":1507},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5df0533d1e694656ac3721e68d3b9004","type":"complex_cell","conversion_output":false,"parent_id":"d5a4bd336a124a87bf2ab6c4cb0672df","children_ids":["02b2613c506444bd8f32bdfc7cf78813","d226a6ab67384577b5bf067124a2272e","643a9ed459b34ae2be672fb1fe2ac798","6721aa96692a4037b2c97f050235f84d","db228ec496fc408fab361194d9bde6f1","72407094bcfb463dbdf1555a16dbc2ba","cc3b7357e24248738f78badfafa1dd91","977000523bae417b905b4aa988079a68","c625fa85a3e942dda6abf3bd34ad742c","230b7944b68c4059922ef4a13eb49587","9ebf1c4946714b43877b428f140bd5eb","5d6272a19a5a4b65bfd071869d62f525","464efd22b03e4828b98810dfc51f6cc1","2453294f65a04e5e84fb26c3d60bc4c2","ca4af50ba3624ce6b6adf4067f90e352","eef0b74d33914504b1d78928529f623a","ddb810dc6d8244fd98ec5d821288f2fa","b9bf87d495f94bdfb82aec1fc8f1057f","796de1c504fb4dc79eab9cacfdf715ac","ad611c484d6c48c9af14a1da84bec5f8","490f3b5aeac5439c9b439a8580b786b3","0a243de2c489424ea81ad87529b4c02d","1ca8dcc695df42deb021af94514a6a0f","949e7537aa9749ab86d83a8f2e15d08e","6d653c668afe4cfc9f8ccc763b4e8d64"],"text":"\\begin{tabular}{l}\n- To evaluate other changes in cartilage morphology in terms of imaging by MRI (sub-regions) \\\\\n- To evaluate changes in physical functioning \\\\\n- To evaluate the safety of sprifermin \\\\\n- To evaluate the pharmacokinetics (PK) of sprifermin in serum and in synovial fluid following i.a. injection \\\\\nExploratory: \\\\\n- To evaluate responder criteria in symptoms \\\\\n- To explore treatment effect on OA pain and other patient-reported outcomes (PROs) \\\\\n- To evaluate changes in quality of life (QOL) \\\\\n- To explore treatment effect on the knee joint and bone structures by MRI \\\\\n- To evaluate long-term treatment effects \\\\\n- To explore the relationship between the change over time in synovial, serum, and urine biomarkers (e.g., cartilage and bone tissue turnover markers, inflammation markers) and the response to the drug \\\\\n- To evaluate potential associations of biomarkers (e.g., genetic variations or protein biomarkers measured at baseline) with drug response, and/or disease severity or disease progression \\\\\n- To explore the relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a function of time, by means of modeling\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n- To evaluate other changes in cartilage morphology in terms of imaging by MRI (sub-regions) \\\\\n- To evaluate changes in physical functioning \\\\\n- To evaluate the safety of sprifermin \\\\\n- To evaluate the pharmacokinetics (PK) of sprifermin in serum and in synovial fluid following i.a. injection \\\\\nExploratory: \\\\\n- To evaluate responder criteria in symptoms \\\\\n- To explore treatment effect on OA pain and other patient-reported outcomes (PROs) \\\\\n- To evaluate changes in quality of life (QOL) \\\\\n- To explore treatment effect on the knee joint and bone structures by MRI \\\\\n- To evaluate long-term treatment effects \\\\\n- To explore the relationship between the change over time in synovial, serum, and urine biomarkers (e.g., cartilage and bone tissue turnover markers, inflammation markers) and the response to the drug \\\\\n- To evaluate potential associations of biomarkers (e.g., genetic variations or protein biomarkers measured at baseline) with drug response, and/or disease severity or disease progression \\\\\n- To explore the relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a function of time, by means of modeling\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[889,304],[1866,304],[1866,356],[889,356]],"region":{"top_left_x":889,"top_left_y":304,"width":978,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02b2613c506444bd8f32bdfc7cf78813","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To evaluate other changes in cartilage morphology in","text_display":"- To evaluate other changes in cartilage morphology in","confidence":1,"confidence_rate":1},{"cnt":[[933,356],[1601,356],[1601,403],[933,403]],"region":{"top_left_x":932,"top_left_y":356,"width":670,"height":47},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d226a6ab67384577b5bf067124a2272e","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"terms of imaging by MRI (sub-regions)","text_display":" terms of imaging by MRI (sub-regions)","confidence":1,"confidence_rate":1},{"cnt":[[889,424],[1683,424],[1683,476],[889,476]],"region":{"top_left_x":889,"top_left_y":424,"width":795,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"643a9ed459b34ae2be672fb1fe2ac798","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To evaluate changes in physical functioning","text_display":"\n- To evaluate changes in physical functioning","confidence":1,"confidence_rate":1},{"cnt":[[889,501],[1541,501],[1541,547],[889,547]],"region":{"top_left_x":889,"top_left_y":500,"width":653,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6721aa96692a4037b2c97f050235f84d","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To evaluate the safety of sprifermin","text_display":"\n- To evaluate the safety of sprifermin","confidence":1,"confidence_rate":1},{"cnt":[[889,572],[1863,572],[1863,618],[889,618]],"region":{"top_left_x":889,"top_left_y":571,"width":975,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db228ec496fc408fab361194d9bde6f1","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To evaluate the pharmacokinetics (PK) of sprifermin","text_display":"\n- To evaluate the pharmacokinetics (PK) of sprifermin","confidence":1,"confidence_rate":1},{"cnt":[[933,621],[1836,621],[1836,667],[933,667]],"region":{"top_left_x":932,"top_left_y":620,"width":905,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72407094bcfb463dbdf1555a16dbc2ba","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"in serum and in synovial fluid following i.a. injection","text_display":" in serum and in synovial fluid following i.a. injection","confidence":1,"confidence_rate":1},{"cnt":[[889,708],[1127,708],[1127,760],[889,760]],"region":{"top_left_x":889,"top_left_y":708,"width":238,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc3b7357e24248738f78badfafa1dd91","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"Exploratory:","text_display":"\nExploratory:","confidence":1,"confidence_rate":1},{"cnt":[[889,782],[1667,782],[1667,831],[889,831]],"region":{"top_left_x":889,"top_left_y":781,"width":778,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"977000523bae417b905b4aa988079a68","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To evaluate responder criteria in symptoms","text_display":"\n- To evaluate responder criteria in symptoms","confidence":1,"confidence_rate":1},{"cnt":[[889,850],[1866,850],[1866,902],[889,902]],"region":{"top_left_x":889,"top_left_y":849,"width":978,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c625fa85a3e942dda6abf3bd34ad742c","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To explore treatment effect on OA pain and other","text_display":"\n- To explore treatment effect on OA pain and other","confidence":1,"confidence_rate":1},{"cnt":[[933,899],[1514,899],[1514,948],[933,948]],"region":{"top_left_x":932,"top_left_y":899,"width":583,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"230b7944b68c4059922ef4a13eb49587","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"patient-reported outcomes (PROs)","text_display":" patient-reported outcomes (PROs)","confidence":1,"confidence_rate":1},{"cnt":[[889,970],[1689,970],[1689,1022],[889,1022]],"region":{"top_left_x":889,"top_left_y":969,"width":800,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ebf1c4946714b43877b428f140bd5eb","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To evaluate changes in quality of life (QOL)","text_display":"\n- To evaluate changes in quality of life (QOL)","confidence":1,"confidence_rate":1},{"cnt":[[889,1044],[1863,1044],[1863,1093],[889,1093]],"region":{"top_left_x":889,"top_left_y":1043,"width":975,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d6272a19a5a4b65bfd071869d62f525","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To explore treatment effect on the knee joint and bone","text_display":"\n- To explore treatment effect on the knee joint and bone","confidence":1,"confidence_rate":1},{"cnt":[[933,1090],[1247,1090],[1247,1136],[933,1136]],"region":{"top_left_x":932,"top_left_y":1090,"width":315,"height":47},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"464efd22b03e4828b98810dfc51f6cc1","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"structures by MRI","text_display":" structures by MRI","confidence":1,"confidence_rate":1},{"cnt":[[889,1161],[1604,1161],[1604,1213],[889,1213]],"region":{"top_left_x":889,"top_left_y":1160,"width":716,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2453294f65a04e5e84fb26c3d60bc4c2","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To evaluate long-term treatment effects","text_display":"\n- To evaluate long-term treatment effects","confidence":1,"confidence_rate":1},{"cnt":[[889,1232],[1866,1232],[1866,1284],[889,1284]],"region":{"top_left_x":889,"top_left_y":1231,"width":978,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca4af50ba3624ce6b6adf4067f90e352","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To explore the relationship between the change over","text_display":"\n- To explore the relationship between the change over","confidence":1,"confidence_rate":1},{"cnt":[[933,1284],[1863,1284],[1863,1333],[933,1333]],"region":{"top_left_x":932,"top_left_y":1283,"width":932,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eef0b74d33914504b1d78928529f623a","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"time in synovial, serum, and urine biomarkers (e.g.,","text_display":" time in synovial, serum, and urine biomarkers (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[933,1330],[1863,1330],[1863,1379],[933,1379]],"region":{"top_left_x":932,"top_left_y":1330,"width":932,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddb810dc6d8244fd98ec5d821288f2fa","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"cartilage and bone tissue turnover markers,","text_display":" cartilage and bone tissue turnover markers,","confidence":1,"confidence_rate":1},{"cnt":[[933,1379],[1809,1379],[1809,1426],[933,1426]],"region":{"top_left_x":932,"top_left_y":1379,"width":877,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9bf87d495f94bdfb82aec1fc8f1057f","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"inflammation markers) and the response to the drug","text_display":" inflammation markers) and the response to the drug","confidence":1,"confidence_rate":1},{"cnt":[[889,1450],[1863,1450],[1863,1502],[889,1502]],"region":{"top_left_x":889,"top_left_y":1450,"width":975,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"796de1c504fb4dc79eab9cacfdf715ac","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To evaluate potential associations of biomarkers (e.g.,","text_display":"\n- To evaluate potential associations of biomarkers (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[933,1499],[1866,1499],[1866,1546],[933,1546]],"region":{"top_left_x":932,"top_left_y":1499,"width":935,"height":47},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad611c484d6c48c9af14a1da84bec5f8","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"genetic variations or protein biomarkers measured at","text_display":" genetic variations or protein biomarkers measured at","confidence":1,"confidence_rate":1},{"cnt":[[933,1546],[1863,1546],[1863,1595],[933,1595]],"region":{"top_left_x":932,"top_left_y":1545,"width":932,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"490f3b5aeac5439c9b439a8580b786b3","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"baseline) with drug response, and/or disease severity","text_display":" baseline) with drug response, and/or disease severity","confidence":1,"confidence_rate":1},{"cnt":[[933,1592],[1315,1592],[1315,1644],[933,1644]],"region":{"top_left_x":932,"top_left_y":1592,"width":383,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a243de2c489424ea81ad87529b4c02d","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"or disease progression","text_display":" or disease progression","confidence":1,"confidence_rate":1},{"cnt":[[889,1663],[1863,1663],[1863,1715],[889,1715]],"region":{"top_left_x":889,"top_left_y":1662,"width":975,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ca8dcc695df42deb021af94514a6a0f","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"- To explore the relationship between dosing (dose and","text_display":"\n- To explore the relationship between dosing (dose and","confidence":1,"confidence_rate":1},{"cnt":[[933,1712],[1866,1712],[1866,1764],[933,1764]],"region":{"top_left_x":932,"top_left_y":1712,"width":935,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"949e7537aa9749ab86d83a8f2e15d08e","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"regimen), cartilage structure, and clinical scores as a","text_display":" regimen), cartilage structure, and clinical scores as a","confidence":1,"confidence_rate":1},{"cnt":[[933,1761],[1607,1761],[1607,1808],[933,1808]],"region":{"top_left_x":932,"top_left_y":1761,"width":675,"height":47},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d653c668afe4cfc9f8ccc763b4e8d64","type":"text","conversion_output":false,"parent_id":"5df0533d1e694656ac3721e68d3b9004","text":"function of time, by means of modeling","text_display":" function of time, by means of modeling","confidence":1,"confidence_rate":1},{"cnt":[[265,1854],[652,1854],[652,1903],[265,1903]],"region":{"top_left_x":264,"top_left_y":1853,"width":388,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d113061f597b451fa8d64860c7cafaec","type":"simple_cell","conversion_output":false,"parent_id":"d5a4bd336a124a87bf2ab6c4cb0672df","text":"Trial design and plan","text_display":"Trial design and plan","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[881,1849],[1872,1849],[1872,2492],[881,2492]],"region":{"top_left_x":881,"top_left_y":1848,"width":991,"height":645},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9076492bd4b44bb186b6b6b0e58d1202","type":"complex_cell","conversion_output":false,"parent_id":"d5a4bd336a124a87bf2ab6c4cb0672df","children_ids":["fa90519a69c845fab737ed3c36ce6d0a","a8fdabd417fe43abbd8dabfb804c0578","93339d9ec5d4413ba7a2e1f07339de1b","19636ee22947421992ddd4079b01622e","ea1b9ddaa3bb46dc989c63828f287423","7733dc646f9f42b99d604acba6df864d","6d86b526cbdb41a589f6d716c8790831","becd66ec3f38411dab4cb0cd7970bdfc","4000054523cb41ca99751896159ebcc7","2dddb4b680b44f30b170e5fe1074dc3e","6ff768efd95a42a3963e8b7c6b8de6a5","21cba5332f2b4394b097788855fed9af"],"text":"\\begin{tabular}{l}\nThe trial consists of a screening period, a double-blind placebo-controlled (DBPC) treatment phase, and an extended follow-up phase. \\\\\nSubject eligibility for the trial will be determined during the screening period based on clinical and radiographic criteria, in addition to responses to pain questionnaires after withdrawal of analgesic medications. \\\\\nIn the 2 -year DBPC treatment phase, subjects will be randomized in equal allocation to one of 5 treatment groups (see below). \\\\\nAll subjects will receive 4 cycles of treatment with the Investigational Medicinal Product (IMP; sprifermin or\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nThe trial consists of a screening period, a double-blind placebo-controlled (DBPC) treatment phase, and an extended follow-up phase. \\\\\nSubject eligibility for the trial will be determined during the screening period based on clinical and radiographic criteria, in addition to responses to pain questionnaires after withdrawal of analgesic medications. \\\\\nIn the 2 -year DBPC treatment phase, subjects will be randomized in equal allocation to one of 5 treatment groups (see below). \\\\\nAll subjects will receive 4 cycles of treatment with the Investigational Medicinal Product (IMP; sprifermin or\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9253292083740234,"confidence_rate":0.9998918489822752},{"cnt":[[889,1854],[1863,1854],[1863,1900],[889,1900]],"region":{"top_left_x":889,"top_left_y":1853,"width":975,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa90519a69c845fab737ed3c36ce6d0a","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"The trial consists of a screening period, a double-blind","text_display":"The trial consists of a screening period, a double-blind","confidence":1,"confidence_rate":1},{"cnt":[[889,1900],[1863,1900],[1863,1949],[889,1949]],"region":{"top_left_x":889,"top_left_y":1900,"width":975,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8fdabd417fe43abbd8dabfb804c0578","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"placebo-controlled (DBPC) treatment phase, and an","text_display":" placebo-controlled (DBPC) treatment phase, and an","confidence":1,"confidence_rate":1},{"cnt":[[889,1949],[1334,1949],[1334,1999],[889,1999]],"region":{"top_left_x":889,"top_left_y":1949,"width":446,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93339d9ec5d4413ba7a2e1f07339de1b","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"extended follow-up phase.","text_display":" extended follow-up phase.","confidence":1,"confidence_rate":1},{"cnt":[[889,2018],[1863,2018],[1863,2067],[889,2067]],"region":{"top_left_x":889,"top_left_y":2017,"width":975,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19636ee22947421992ddd4079b01622e","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"Subject eligibility for the trial will be determined during","text_display":"\nSubject eligibility for the trial will be determined during","confidence":1,"confidence_rate":1},{"cnt":[[889,2067],[1863,2067],[1863,2113],[889,2113]],"region":{"top_left_x":889,"top_left_y":2066,"width":975,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea1b9ddaa3bb46dc989c63828f287423","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"the screening period based on clinical and radiographic","text_display":" the screening period based on clinical and radiographic","confidence":1,"confidence_rate":1},{"cnt":[[889,2113],[1863,2113],[1863,2162],[889,2162]],"region":{"top_left_x":889,"top_left_y":2113,"width":975,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7733dc646f9f42b99d604acba6df864d","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"criteria, in addition to responses to pain questionnaires","text_display":" criteria, in addition to responses to pain questionnaires","confidence":1,"confidence_rate":1},{"cnt":[[889,2160],[1601,2160],[1601,2211],[889,2211]],"region":{"top_left_x":889,"top_left_y":2159,"width":713,"height":53},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d86b526cbdb41a589f6d716c8790831","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"after withdrawal of analgesic medications.","text_display":" after withdrawal of analgesic medications.","confidence":0.99951171875,"confidence_rate":0.9999896085540316},{"cnt":[[889,2230],[1863,2230],[1863,2277],[889,2277]],"region":{"top_left_x":889,"top_left_y":2230,"width":975,"height":47},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"becd66ec3f38411dab4cb0cd7970bdfc","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"In the 2 -year DBPC treatment phase, subjects will be","text_display":"\nIn the 2 -year DBPC treatment phase, subjects will be","confidence":0.9253292083740234,"confidence_rate":0.9987285842815424},{"cnt":[[889,2280],[1866,2280],[1866,2326],[889,2326]],"region":{"top_left_x":889,"top_left_y":2279,"width":978,"height":47},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4000054523cb41ca99751896159ebcc7","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"randomized in equal allocation to one of 5 treatment","text_display":" randomized in equal allocation to one of 5 treatment","confidence":1,"confidence_rate":1},{"cnt":[[889,2323],[1219,2323],[1219,2375],[889,2375]],"region":{"top_left_x":889,"top_left_y":2323,"width":331,"height":53},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2dddb4b680b44f30b170e5fe1074dc3e","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"groups (see below).","text_display":" groups (see below).","confidence":1,"confidence_rate":1},{"cnt":[[889,2394],[1863,2394],[1863,2443],[889,2443]],"region":{"top_left_x":889,"top_left_y":2394,"width":975,"height":50},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ff768efd95a42a3963e8b7c6b8de6a5","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"All subjects will receive 4 cycles of treatment with the","text_display":"\nAll subjects will receive 4 cycles of treatment with the","confidence":0.9990234375,"confidence_rate":0.9999847338720312},{"cnt":[[887,2443],[1863,2443],[1863,2490],[887,2490]],"region":{"top_left_x":886,"top_left_y":2443,"width":978,"height":47},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21cba5332f2b4394b097788855fed9af","type":"text","conversion_output":false,"parent_id":"9076492bd4b44bb186b6b6b0e58d1202","text":"Investigational Medicinal Product (IMP; sprifermin or","text_display":" Investigational Medicinal Product (IMP; sprifermin or","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[440,2509],[440,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":197,"height":37},"line":49,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"49a58ae4328048cebf0bd3d5a436faed","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2546],[389,2543],[390,2587],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":146,"height":47},"line":50,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"315026699c104cdc95c7f07354b86c68","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2522],[1601,2522],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2522,"width":93,"height":42},"line":51,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c232e400117f4aa9aa70a62b543a24e8","type":"page_info","conversion_output":false,"text":"18/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-019","page":19,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de1f82b7236c4c17b173b1bbbfe6a5b5","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3dd33edaf2fe40c2aca44f916bcbff29","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2b39d2cb9c74c4abf2a4368137992c5","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,271],[1886,271],[1886,2496],[241,2496]],"region":{"top_left_x":240,"top_left_y":270,"width":1647,"height":2227},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20eceb72ac4640ba8344e1ef9365bc27","type":"table","conversion_output":true,"children_ids":["005312c839b04a9d9ff6c86f158417f3","03243a382ebc4ac0a540ef876b693f17","ba6c2743b51545c782a97663cbd67c8e","7b296ace30a34d9e9f9586d29fa59996","2554dfd4627c46489af6a88f693c5e68","f8c27993cf704bbaab31dce463103778","eb7a8eb1d2b44a10b9cadd33b11a9e90","d40ca1399151442982e71fe257ff9ee9","5751a22113ad46b9a8b928e7f0397d8d","6c5984dc9e484992ab2eb8ef13223ee6"],"text":"\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\nmatching placebo) at intervals of 6 months. Each cycle will consist of 3 once-weekly i.a. injections over a period of 3 consecutive weeks. \\\\\nEfficacy assessments will include MRI and X-ray of the target knee, the WOMAC, the 20 -meter walk test, and a Patient's Global Assessment of disease impact (PGA). The Patient Global Impression of Change (PGIC), the Knee Injury and Osteoarthritis Outcome Score (KOOS) QOL subscale (KOOS QOL), the KOOS Symptom Index, the Medical Outcomes Study Short Form-36 General Health Survey (MOS SF-36), assessment of pain (on a numerical rating scale [NRS]) in the target and contralateral knee, identification of pain in other joints, and the Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire will be assessed as exploratory outcomes. \\\\\nAdverse events (AEs), concomitant medications, and procedures will be monitored throughout the trial. \\\\\nSee below for details of safety and other assessments. \\\\\nThe 3-year extended follow-up phase will include periodic assessment of the WOMAC, NRS pain score in the target and contralateral knee, PGA, PGIC, KOOS QOL and Symptom Index, MOS SF-36, 20-meter walk test, identification of pain in other joints, and ICOAP as well as safety assessments. MRI and X-ray will be performed at yearly intervals. \\\\\nIt is planned to perform the statistical analysis in two steps, as described in Section 8.5.1: results from the DBPC treatment phase will be analyzed and reported at the end of this phase, and long-term follow-up data will be analyzed and reported separately. MRI readers, Investigators, and subjects will remain blinded during the extended follow-up phase.\n\\end{tabular} \\\\\n\\hline Planned number of subjects & \\begin{tabular}{l}\n545 subjects will be randomized. \\\\\nApproximately 10 to 15 trial sites in Europe, the United States, and possibly other geographical regions will participate in the trial.\n\\end{tabular} \\\\\n\\hline Schedule of visits and assessments & The screening period will comprise a period of 4 to 42 days during which a subject's eligibility will be \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\nmatching placebo) at intervals of 6 months. Each cycle will consist of 3 once-weekly i.a. injections over a period of 3 consecutive weeks. \\\\\nEfficacy assessments will include MRI and X-ray of the target knee, the WOMAC, the 20 -meter walk test, and a Patient's Global Assessment of disease impact (PGA). The Patient Global Impression of Change (PGIC), the Knee Injury and Osteoarthritis Outcome Score (KOOS) QOL subscale (KOOS QOL), the KOOS Symptom Index, the Medical Outcomes Study Short Form-36 General Health Survey (MOS SF-36), assessment of pain (on a numerical rating scale [NRS]) in the target and contralateral knee, identification of pain in other joints, and the Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire will be assessed as exploratory outcomes. \\\\\nAdverse events (AEs), concomitant medications, and procedures will be monitored throughout the trial. \\\\\nSee below for details of safety and other assessments. \\\\\nThe 3-year extended follow-up phase will include periodic assessment of the WOMAC, NRS pain score in the target and contralateral knee, PGA, PGIC, KOOS QOL and Symptom Index, MOS SF-36, 20-meter walk test, identification of pain in other joints, and ICOAP as well as safety assessments. MRI and X-ray will be performed at yearly intervals. \\\\\nIt is planned to perform the statistical analysis in two steps, as described in Section 8.5.1: results from the DBPC treatment phase will be analyzed and reported at the end of this phase, and long-term follow-up data will be analyzed and reported separately. MRI readers, Investigators, and subjects will remain blinded during the extended follow-up phase.\n\\end{tabular} \\\\\n\\hline Planned number of subjects & \\begin{tabular}{l}\n545 subjects will be randomized. \\\\\nApproximately 10 to 15 trial sites in Europe, the United States, and possibly other geographical regions will participate in the trial.\n\\end{tabular} \\\\\n\\hline Schedule of visits and assessments & The screening period will comprise a period of 4 to 42 days during which a subject's eligibility will be \\\\\n\\hline\n\\end{tabular}","confidence":0.916015625,"confidence_rate":0.9999860783915113},{"cnt":[[251,270],[777,270],[777,2499],[251,2499]],"region":{"top_left_x":250,"top_left_y":270,"width":528,"height":2230},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"005312c839b04a9d9ff6c86f158417f3","type":"table_column","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","text":"","text_display":""},{"cnt":[[865,270],[1885,270],[1885,2496],[865,2496]],"region":{"top_left_x":864,"top_left_y":270,"width":1022,"height":2227},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03243a382ebc4ac0a540ef876b693f17","type":"table_column","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","text":"","text_display":""},{"cnt":[[240,275],[1888,275],[1888,2079],[240,2079]],"region":{"top_left_x":240,"top_left_y":275,"width":1648,"height":1804},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba6c2743b51545c782a97663cbd67c8e","type":"table_row","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","text":"","text_display":""},{"cnt":[[240,2106],[1888,2106],[1888,2357],[240,2357]],"region":{"top_left_x":240,"top_left_y":2106,"width":1648,"height":252},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b296ace30a34d9e9f9586d29fa59996","type":"table_row","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","text":"","text_display":""},{"cnt":[[240,2379],[1888,2379],[1888,2499],[240,2499]],"region":{"top_left_x":240,"top_left_y":2379,"width":1648,"height":121},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2554dfd4627c46489af6a88f693c5e68","type":"table_row","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","text":"","text_display":""},{"cnt":[[881,278],[1872,278],[1872,2076],[881,2076]],"region":{"top_left_x":881,"top_left_y":278,"width":991,"height":1799},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8c27993cf704bbaab31dce463103778","type":"complex_cell","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","children_ids":["54e40225706f447aa885cd0070f7f1f1","eee4df800b80491082958792345d8ff1","3e28e555613f46cbac078b045e6cd51d","4d29bdd80f234d6b8f9a47fea12c96a8","2c4a50f7063b4df8bd0f570f70021311","edf586085fbe40e4acc77e7350161923","30711ec35b93476080ff8d24c52bc66e","d7ea8aa574b941c291a30f366ee97493","9204fd7c363243f7a318c58a24326ede","1507fbea6fce498d84fc1de43a65adcf","72328cb860c74e6c8e9a4ea9ac80819e","34e93340d3574425bdc2e0053b783e5d","88557a49aca042e8b64f21d1629ba96e","a429d92324424f90ab6fda37e8f8abec","a833519b6ecb4f43b64c785cc2884299","35e13f8be33a4200b5282258078df809","172cc331a31b46588e22c815ee0d6d64","74c3ee0552cc4193883216758561a2ae","1b845919190347c0b181477f6e7a2e33","1c0a922ca5a846eb9ce4a6c6169de203","822d9579170b4f5e8165bad7f936eb6a","59390447a6d041e29af786f88b4d3ca3","7e521b3909e345afa987791a8959de75","c3b57b6f6456462987ff4fb9cf76f03d","769959d289d2482da8a39b3c02e22431","86733958e2ed4138ae41839eb86d30c2","6d21e90c62614a348a05f50e91228540","1218f5cde70d4dbd961eac375a6c5688","e79bf1949e474822897819401994b152","6c62cf6d237849d89109950ab00a6649","27ff1a770588437dbd7044a9db115b69","72819f1905dd422d92cd51f8efdcd45b","c8144474d1994757b945a197a3f3a5ac"],"text":"\\begin{tabular}{l}\nmatching placebo) at intervals of 6 months. Each cycle will consist of 3 once-weekly i.a. injections over a period of 3 consecutive weeks. \\\\\nEfficacy assessments will include MRI and X-ray of the target knee, the WOMAC, the 20 -meter walk test, and a Patient's Global Assessment of disease impact (PGA). The Patient Global Impression of Change (PGIC), the Knee Injury and Osteoarthritis Outcome Score (KOOS) QOL subscale (KOOS QOL), the KOOS Symptom Index, the Medical Outcomes Study Short Form-36 General Health Survey (MOS SF-36), assessment of pain (on a numerical rating scale [NRS]) in the target and contralateral knee, identification of pain in other joints, and the Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire will be assessed as exploratory outcomes. \\\\\nAdverse events (AEs), concomitant medications, and procedures will be monitored throughout the trial. \\\\\nSee below for details of safety and other assessments. \\\\\nThe 3-year extended follow-up phase will include periodic assessment of the WOMAC, NRS pain score in the target and contralateral knee, PGA, PGIC, KOOS QOL and Symptom Index, MOS SF-36, 20-meter walk test, identification of pain in other joints, and ICOAP as well as safety assessments. MRI and X-ray will be performed at yearly intervals. \\\\\nIt is planned to perform the statistical analysis in two steps, as described in Section 8.5.1: results from the DBPC treatment phase will be analyzed and reported at the end of this phase, and long-term follow-up data will be analyzed and reported separately. MRI readers, Investigators, and subjects will remain blinded during the extended follow-up phase.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nmatching placebo) at intervals of 6 months. Each cycle will consist of 3 once-weekly i.a. injections over a period of 3 consecutive weeks. \\\\\nEfficacy assessments will include MRI and X-ray of the target knee, the WOMAC, the 20 -meter walk test, and a Patient's Global Assessment of disease impact (PGA). The Patient Global Impression of Change (PGIC), the Knee Injury and Osteoarthritis Outcome Score (KOOS) QOL subscale (KOOS QOL), the KOOS Symptom Index, the Medical Outcomes Study Short Form-36 General Health Survey (MOS SF-36), assessment of pain (on a numerical rating scale [NRS]) in the target and contralateral knee, identification of pain in other joints, and the Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire will be assessed as exploratory outcomes. \\\\\nAdverse events (AEs), concomitant medications, and procedures will be monitored throughout the trial. \\\\\nSee below for details of safety and other assessments. \\\\\nThe 3-year extended follow-up phase will include periodic assessment of the WOMAC, NRS pain score in the target and contralateral knee, PGA, PGIC, KOOS QOL and Symptom Index, MOS SF-36, 20-meter walk test, identification of pain in other joints, and ICOAP as well as safety assessments. MRI and X-ray will be performed at yearly intervals. \\\\\nIt is planned to perform the statistical analysis in two steps, as described in Section 8.5.1: results from the DBPC treatment phase will be analyzed and reported at the end of this phase, and long-term follow-up data will be analyzed and reported separately. MRI readers, Investigators, and subjects will remain blinded during the extended follow-up phase.\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.916015625,"confidence_rate":0.999932216160371},{"cnt":[[887,281],[1869,281],[1869,333],[887,333]],"region":{"top_left_x":886,"top_left_y":280,"width":983,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54e40225706f447aa885cd0070f7f1f1","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"matching placebo) at intervals of 6 months. Each cycle","text_display":"matching placebo) at intervals of 6 months. Each cycle","confidence":1,"confidence_rate":1},{"cnt":[[889,330],[1869,330],[1869,382],[889,382]],"region":{"top_left_x":889,"top_left_y":330,"width":980,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eee4df800b80491082958792345d8ff1","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"will consist of 3 once-weekly i.a. injections over a period","text_display":" will consist of 3 once-weekly i.a. injections over a period","confidence":0.99951171875,"confidence_rate":0.9999927104668955},{"cnt":[[889,379],[1290,379],[1290,426],[889,426]],"region":{"top_left_x":889,"top_left_y":379,"width":402,"height":47},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e28e555613f46cbac078b045e6cd51d","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"of 3 consecutive weeks.","text_display":" of 3 consecutive weeks.","confidence":1,"confidence_rate":1},{"cnt":[[887,466],[1866,466],[1866,518],[887,518]],"region":{"top_left_x":886,"top_left_y":466,"width":981,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d29bdd80f234d6b8f9a47fea12c96a8","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"Efficacy assessments will include MRI and X-ray of the","text_display":"\nEfficacy assessments will include MRI and X-ray of the","confidence":1,"confidence_rate":1},{"cnt":[[887,516],[1869,516],[1869,567],[887,567]],"region":{"top_left_x":886,"top_left_y":515,"width":983,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c4a50f7063b4df8bd0f570f70021311","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"target knee, the WOMAC, the 20 -meter walk test, and a","text_display":" target knee, the WOMAC, the 20 -meter walk test, and a","confidence":1,"confidence_rate":1},{"cnt":[[887,565],[1863,565],[1863,614],[887,614]],"region":{"top_left_x":886,"top_left_y":564,"width":978,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edf586085fbe40e4acc77e7350161923","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"Patient's Global Assessment of disease impact (PGA).","text_display":" Patient's Global Assessment of disease impact (PGA).","confidence":0.99951171875,"confidence_rate":0.9999914316069175},{"cnt":[[887,611],[1866,611],[1866,660],[887,660]],"region":{"top_left_x":886,"top_left_y":611,"width":981,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30711ec35b93476080ff8d24c52bc66e","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"The Patient Global Impression of Change (PGIC), the","text_display":" The Patient Global Impression of Change (PGIC), the","confidence":1,"confidence_rate":1},{"cnt":[[887,657],[1866,657],[1866,709],[887,709]],"region":{"top_left_x":886,"top_left_y":657,"width":981,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7ea8aa574b941c291a30f366ee97493","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"Knee Injury and Osteoarthritis Outcome Score (KOOS)","text_display":" Knee Injury and Osteoarthritis Outcome Score (KOOS)","confidence":0.98681640625,"confidence_rate":0.9997630411371197},{"cnt":[[887,709],[1866,709],[1866,758],[887,758]],"region":{"top_left_x":886,"top_left_y":709,"width":981,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9204fd7c363243f7a318c58a24326ede","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"QOL subscale (KOOS QOL), the KOOS Symptom","text_display":" QOL subscale (KOOS QOL), the KOOS Symptom","confidence":1,"confidence_rate":1},{"cnt":[[887,756],[1869,756],[1869,805],[887,805]],"region":{"top_left_x":886,"top_left_y":755,"width":983,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1507fbea6fce498d84fc1de43a65adcf","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"Index, the Medical Outcomes Study Short Form-36","text_display":" Index, the Medical Outcomes Study Short Form-36","confidence":1,"confidence_rate":1},{"cnt":[[887,805],[1869,805],[1869,854],[887,854]],"region":{"top_left_x":886,"top_left_y":804,"width":983,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72328cb860c74e6c8e9a4ea9ac80819e","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"General Health Survey (MOS SF-36), assessment of pain","text_display":" General Health Survey (MOS SF-36), assessment of pain","confidence":1,"confidence_rate":1},{"cnt":[[887,851],[1869,851],[1869,906],[887,906]],"region":{"top_left_x":886,"top_left_y":851,"width":983,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34e93340d3574425bdc2e0053b783e5d","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"(on a numerical rating scale [NRS]) in the target and","text_display":" (on a numerical rating scale [NRS]) in the target and","confidence":1,"confidence_rate":1},{"cnt":[[887,898],[1866,898],[1866,949],[887,949]],"region":{"top_left_x":886,"top_left_y":897,"width":981,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88557a49aca042e8b64f21d1629ba96e","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"contralateral knee, identification of pain in other joints,","text_display":" contralateral knee, identification of pain in other joints,","confidence":1,"confidence_rate":1},{"cnt":[[887,947],[1869,947],[1869,993],[887,993]],"region":{"top_left_x":886,"top_left_y":946,"width":983,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a429d92324424f90ab6fda37e8f8abec","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"and the Measure of Intermittent and Constant","text_display":" and the Measure of Intermittent and Constant","confidence":1,"confidence_rate":1},{"cnt":[[887,993],[1869,993],[1869,1045],[887,1045]],"region":{"top_left_x":886,"top_left_y":993,"width":983,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a833519b6ecb4f43b64c785cc2884299","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"Osteoarthritis Pain (ICOAP) questionnaire will be","text_display":" Osteoarthritis Pain (ICOAP) questionnaire will be","confidence":1,"confidence_rate":1},{"cnt":[[884,1045],[1465,1045],[1465,1094],[884,1094]],"region":{"top_left_x":883,"top_left_y":1044,"width":583,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35e13f8be33a4200b5282258078df809","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"assessed as exploratory outcomes.","text_display":" assessed as exploratory outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[884,1132],[1869,1132],[1869,1184],[884,1184]],"region":{"top_left_x":883,"top_left_y":1132,"width":986,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"172cc331a31b46588e22c815ee0d6d64","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"Adverse events (AEs), concomitant medications, and","text_display":"\nAdverse events (AEs), concomitant medications, and","confidence":1,"confidence_rate":1},{"cnt":[[884,1181],[1727,1181],[1727,1233],[884,1233]],"region":{"top_left_x":883,"top_left_y":1181,"width":844,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74c3ee0552cc4193883216758561a2ae","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"procedures will be monitored throughout the trial.","text_display":" procedures will be monitored throughout the trial.","confidence":1,"confidence_rate":1},{"cnt":[[887,1269],[1792,1269],[1792,1320],[887,1320]],"region":{"top_left_x":886,"top_left_y":1268,"width":907,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b845919190347c0b181477f6e7a2e33","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"See below for details of safety and other assessments.","text_display":"\nSee below for details of safety and other assessments.","confidence":1,"confidence_rate":1},{"cnt":[[887,1356],[1866,1356],[1866,1408],[887,1408]],"region":{"top_left_x":886,"top_left_y":1355,"width":981,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c0a922ca5a846eb9ce4a6c6169de203","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"The 3-year extended follow-up phase will include","text_display":"\nThe 3-year extended follow-up phase will include","confidence":0.984375,"confidence_rate":0.9997029053306447},{"cnt":[[884,1408],[1869,1408],[1869,1460],[884,1460]],"region":{"top_left_x":883,"top_left_y":1407,"width":986,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"822d9579170b4f5e8165bad7f936eb6a","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"periodic assessment of the WOMAC, NRS pain score in","text_display":" periodic assessment of the WOMAC, NRS pain score in","confidence":1,"confidence_rate":1},{"cnt":[[887,1454],[1863,1454],[1863,1506],[887,1506]],"region":{"top_left_x":886,"top_left_y":1454,"width":978,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59390447a6d041e29af786f88b4d3ca3","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"the target and contralateral knee, PGA, PGIC, KOOS","text_display":" the target and contralateral knee, PGA, PGIC, KOOS","confidence":1,"confidence_rate":1},{"cnt":[[887,1503],[1869,1503],[1869,1555],[887,1555]],"region":{"top_left_x":886,"top_left_y":1503,"width":983,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e521b3909e345afa987791a8959de75","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"QOL and Symptom Index, MOS SF-36, 20-meter walk","text_display":" QOL and Symptom Index, MOS SF-36, 20-meter walk","confidence":0.916015625,"confidence_rate":0.9983144633345291},{"cnt":[[887,1552],[1866,1552],[1866,1604],[887,1604]],"region":{"top_left_x":886,"top_left_y":1552,"width":981,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3b57b6f6456462987ff4fb9cf76f03d","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"test, identification of pain in other joints, and ICOAP as","text_display":" test, identification of pain in other joints, and ICOAP as","confidence":1,"confidence_rate":1},{"cnt":[[887,1596],[1869,1596],[1869,1648],[887,1648]],"region":{"top_left_x":886,"top_left_y":1595,"width":983,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"769959d289d2482da8a39b3c02e22431","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"well as safety assessments. MRI and X-ray will be","text_display":" well as safety assessments. MRI and X-ray will be","confidence":1,"confidence_rate":1},{"cnt":[[884,1648],[1389,1648],[1389,1697],[884,1697]],"region":{"top_left_x":883,"top_left_y":1647,"width":506,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86733958e2ed4138ae41839eb86d30c2","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"performed at yearly intervals.","text_display":" performed at yearly intervals.","confidence":1,"confidence_rate":1},{"cnt":[[884,1735],[1866,1735],[1866,1787],[884,1787]],"region":{"top_left_x":883,"top_left_y":1735,"width":984,"height":52},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d21e90c62614a348a05f50e91228540","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"It is planned to perform the statistical analysis in two","text_display":"\nIt is planned to perform the statistical analysis in two","confidence":1,"confidence_rate":1},{"cnt":[[887,1784],[1869,1784],[1869,1833],[887,1833]],"region":{"top_left_x":886,"top_left_y":1784,"width":983,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1218f5cde70d4dbd961eac375a6c5688","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"steps, as described in Section 8.5.1: results from the","text_display":" steps, as described in Section 8.5.1: results from the","confidence":1,"confidence_rate":1},{"cnt":[[887,1831],[1869,1831],[1869,1882],[887,1882]],"region":{"top_left_x":886,"top_left_y":1830,"width":983,"height":53},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e79bf1949e474822897819401994b152","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"DBPC treatment phase will be analyzed and reported at","text_display":" DBPC treatment phase will be analyzed and reported at","confidence":1,"confidence_rate":1},{"cnt":[[887,1880],[1866,1880],[1866,1932],[887,1932]],"region":{"top_left_x":886,"top_left_y":1879,"width":981,"height":53},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c62cf6d237849d89109950ab00a6649","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"the end of this phase, and long-term follow-up data will","text_display":" the end of this phase, and long-term follow-up data will","confidence":1,"confidence_rate":1},{"cnt":[[884,1929],[1866,1929],[1866,1981],[884,1981]],"region":{"top_left_x":883,"top_left_y":1928,"width":984,"height":53},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27ff1a770588437dbd7044a9db115b69","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"be analyzed and reported separately. MRI readers,","text_display":" be analyzed and reported separately. MRI readers,","confidence":1,"confidence_rate":1},{"cnt":[[884,1978],[1869,1978],[1869,2027],[884,2027]],"region":{"top_left_x":883,"top_left_y":1977,"width":986,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72819f1905dd422d92cd51f8efdcd45b","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"Investigators, and subjects will remain blinded during the","text_display":" Investigators, and subjects will remain blinded during the","confidence":1,"confidence_rate":1},{"cnt":[[884,2024],[1340,2024],[1340,2073],[884,2073]],"region":{"top_left_x":883,"top_left_y":2024,"width":457,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8144474d1994757b945a197a3f3a5ac","type":"text","conversion_output":false,"parent_id":"f8c27993cf704bbaab31dce463103778","text":"extended follow-up phase.","text_display":" extended follow-up phase.","confidence":1,"confidence_rate":1},{"cnt":[[262,2114],[772,2114],[772,2166],[262,2166]],"region":{"top_left_x":261,"top_left_y":2114,"width":512,"height":53},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb7a8eb1d2b44a10b9cadd33b11a9e90","type":"simple_cell","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","text":"Planned number of subjects","text_display":"Planned number of subjects","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[881,2109],[1872,2109],[1872,2354],[881,2354]],"region":{"top_left_x":881,"top_left_y":2108,"width":991,"height":247},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d40ca1399151442982e71fe257ff9ee9","type":"complex_cell","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","children_ids":["6b2f0647155b412d94c44af6c96818b9","2739f839a9d24cadad38df595525ad57","d80387c8e0954bc8b4f15165637b96bf","136ef27798b34b069b22d01e20f1d407"],"text":"\\begin{tabular}{l}\n545 subjects will be randomized. \\\\\nApproximately 10 to 15 trial sites in Europe, the United States, and possibly other geographical regions will participate in the trial.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n545 subjects will be randomized. \\\\\nApproximately 10 to 15 trial sites in Europe, the United States, and possibly other geographical regions will participate in the trial.\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999981776117423},{"cnt":[[887,2114],[1449,2114],[1449,2166],[887,2166]],"region":{"top_left_x":886,"top_left_y":2114,"width":563,"height":53},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b2f0647155b412d94c44af6c96818b9","type":"text","conversion_output":false,"parent_id":"d40ca1399151442982e71fe257ff9ee9","text":"545 subjects will be randomized.","text_display":"545 subjects will be randomized.","confidence":1,"confidence_rate":1},{"cnt":[[887,2202],[1869,2202],[1869,2254],[887,2254]],"region":{"top_left_x":886,"top_left_y":2201,"width":983,"height":53},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2739f839a9d24cadad38df595525ad57","type":"text","conversion_output":false,"parent_id":"d40ca1399151442982e71fe257ff9ee9","text":"Approximately 10 to 15 trial sites in Europe, the United","text_display":"\nApproximately 10 to 15 trial sites in Europe, the United","confidence":0.99951171875,"confidence_rate":0.9999927104668955},{"cnt":[[887,2251],[1869,2251],[1869,2303],[887,2303]],"region":{"top_left_x":886,"top_left_y":2250,"width":983,"height":53},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d80387c8e0954bc8b4f15165637b96bf","type":"text","conversion_output":false,"parent_id":"d40ca1399151442982e71fe257ff9ee9","text":"States, and possibly other geographical regions will","text_display":" States, and possibly other geographical regions will","confidence":1,"confidence_rate":1},{"cnt":[[887,2300],[1263,2300],[1263,2352],[887,2352]],"region":{"top_left_x":886,"top_left_y":2299,"width":378,"height":53},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"136ef27798b34b069b22d01e20f1d407","type":"text","conversion_output":false,"parent_id":"d40ca1399151442982e71fe257ff9ee9","text":"participate in the trial.","text_display":" participate in the trial.","confidence":1,"confidence_rate":1},{"cnt":[[262,2387],[663,2387],[663,2488],[262,2488]],"region":{"top_left_x":261,"top_left_y":2387,"width":402,"height":102},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5751a22113ad46b9a8b928e7f0397d8d","type":"complex_cell","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","children_ids":["660cd093be3b413b902c3a5c2fe6975f","00236190c6b5483ab076266a6e57cd99"],"text":"Schedule of visits and assessments","text_display":"Schedule of visits and assessments","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[265,2393],[657,2393],[657,2439],[265,2439]],"region":{"top_left_x":264,"top_left_y":2392,"width":394,"height":48},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"660cd093be3b413b902c3a5c2fe6975f","type":"text","conversion_output":false,"parent_id":"5751a22113ad46b9a8b928e7f0397d8d","text":"Schedule of visits and","text_display":"Schedule of visits and","confidence":1,"confidence_rate":1},{"cnt":[[265,2442],[483,2442],[483,2483],[265,2483]],"region":{"top_left_x":264,"top_left_y":2441,"width":219,"height":42},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00236190c6b5483ab076266a6e57cd99","type":"text","conversion_output":false,"parent_id":"5751a22113ad46b9a8b928e7f0397d8d","text":"assessments","text_display":" assessments","confidence":1,"confidence_rate":1},{"cnt":[[884,2382],[1872,2382],[1872,2491],[884,2491]],"region":{"top_left_x":883,"top_left_y":2381,"width":989,"height":110},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c5984dc9e484992ab2eb8ef13223ee6","type":"complex_cell","conversion_output":false,"parent_id":"20eceb72ac4640ba8344e1ef9365bc27","children_ids":["d49d7e8cf6ce4cbaaa34ea9b4142fa4c","4036c90762c84ff5bd2dbe390a87b923"],"text":"The screening period will comprise a period of 4 to 42 days during which a subject's eligibility will be","text_display":"The screening period will comprise a period of 4 to 42 days during which a subject's eligibility will be","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[887,2393],[1866,2393],[1866,2442],[887,2442]],"region":{"top_left_x":886,"top_left_y":2392,"width":981,"height":50},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d49d7e8cf6ce4cbaaa34ea9b4142fa4c","type":"text","conversion_output":false,"parent_id":"6c5984dc9e484992ab2eb8ef13223ee6","text":"The screening period will comprise a period of 4 to 42","text_display":"The screening period will comprise a period of 4 to 42","confidence":1,"confidence_rate":1},{"cnt":[[887,2439],[1866,2439],[1866,2491],[887,2491]],"region":{"top_left_x":886,"top_left_y":2439,"width":981,"height":52},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4036c90762c84ff5bd2dbe390a87b923","type":"text","conversion_output":false,"parent_id":"6c5984dc9e484992ab2eb8ef13223ee6","text":"days during which a subject's eligibility will be","text_display":" days during which a subject's eligibility will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":56,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b647cc68f86549938c012d04767524aa","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":40},"line":57,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e9a546949e3340a58378ae83e97518a5","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2522],[1601,2522],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2522,"width":93,"height":42},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14fddbc249ba416f95823060a138eb3b","type":"page_info","conversion_output":false,"text":"19/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-020","page":20,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"903b2e52a88c41fdb5a12e04b802e1ec","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04bb9f11cdec4da49984b3268b262685","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"737e2b91518b4d1f84cb86c3c86c58a4","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[230,271],[1886,271],[1886,2499],[230,2499]],"region":{"top_left_x":229,"top_left_y":270,"width":1658,"height":2229},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0c8e72c708b4ef29a7a98b22db5af6b","type":"table","conversion_output":true,"children_ids":["ccd2e90d37a0487c8d13ef320c42c73c","f62891704e944a2bbf4a09ba31500f72","9a3ecea462714374b1fe0ee04e011c16","491d7fdbbf294372a43087ade4543ea5","4154bee363cc4e82bf6710fce4acc8ef","0c49348c91d54b5f816adbe538592bee","9dc540e505674d7c9a0f1e994254424d"],"text":"\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\ndetermined, beginning at signature of the ICF. During the screening visits, eligibility will be assessed and the target knee will be defined. At the baseline visit, eligibility will be confirmed, randomization will occur, and the first IMP injection will be given (Week 0/Visit 2). The last of the four cycles of 3 injections of IMP will be given on Week 78/Visit 17, and the last dose of IMP is scheduled to be administered at Week 80/Visit 19. \\\\\nTrial visits during the two-year DBPC treatment phase will take place at Weeks 0 (randomization and first IMP injection), \\(1,2,3,12,26,27,28,29,38,52,53,54,55\\), 64, 78, 79, 80, 81, 90, and 104. \\\\\nMajor efficacy assessments will take place on the first day of each treatment cycle and then at the end of the DBPC treatment phase (Week 104/Visit 22). \\\\\nMinor efficacy assessments will take place 9 weeks after each treatment cycle. \\\\\nAEs and concomitant medications will be reviewed and vital signs will be measured at all trial visits. \\\\\nTrial assessments during the 3-year extended follow-up phase will take place at 6 -month intervals from Week 104/Visit 22 through Week 260/Visit 28.\n\\end{tabular} \\\\\n\\hline Diagnosis and main inclusion and exclusion criteria & \\begin{tabular}{l}\nThe trial will enroll adult subjects of either sex with primary femorotibial osteoarthritis according to American College of Rheumatology (ACR) clinical and radiographic criteria who have Kellgren-Lawrence grades of 2 or 3 and a minimum joint space width (JSW) of \\(\\geq 2.5\\) mm in the medial compartment. \\\\\nSubjects must have pain in the target knee on most days and/or require symptomatic treatment of knee pain with paracetamol (acetaminophen), systemic non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 selective inhibitor (coxibs), or tramadol on most days of the previous month, and must have both: \\\\\n- A history of pain due to OA in the target knee for at least 6 months, and \\\\\n- Pain score for the target knee of 4 to 9 points in response to Question 1 of the WOMAC pain index (\"how much pain have you had [in the target knee,\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\ndetermined, beginning at signature of the ICF. During the screening visits, eligibility will be assessed and the target knee will be defined. At the baseline visit, eligibility will be confirmed, randomization will occur, and the first IMP injection will be given (Week 0/Visit 2). The last of the four cycles of 3 injections of IMP will be given on Week 78/Visit 17, and the last dose of IMP is scheduled to be administered at Week 80/Visit 19. \\\\\nTrial visits during the two-year DBPC treatment phase will take place at Weeks 0 (randomization and first IMP injection), \\(1,2,3,12,26,27,28,29,38,52,53,54,55\\), 64, 78, 79, 80, 81, 90, and 104. \\\\\nMajor efficacy assessments will take place on the first day of each treatment cycle and then at the end of the DBPC treatment phase (Week 104/Visit 22). \\\\\nMinor efficacy assessments will take place 9 weeks after each treatment cycle. \\\\\nAEs and concomitant medications will be reviewed and vital signs will be measured at all trial visits. \\\\\nTrial assessments during the 3-year extended follow-up phase will take place at 6 -month intervals from Week 104/Visit 22 through Week 260/Visit 28.\n\\end{tabular} \\\\\n\\hline Diagnosis and main inclusion and exclusion criteria & \\begin{tabular}{l}\nThe trial will enroll adult subjects of either sex with primary femorotibial osteoarthritis according to American College of Rheumatology (ACR) clinical and radiographic criteria who have Kellgren-Lawrence grades of 2 or 3 and a minimum joint space width (JSW) of \\(\\geq 2.5\\) mm in the medial compartment. \\\\\nSubjects must have pain in the target knee on most days and/or require symptomatic treatment of knee pain with paracetamol (acetaminophen), systemic non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 selective inhibitor (coxibs), or tramadol on most days of the previous month, and must have both: \\\\\n- A history of pain due to OA in the target knee for at least 6 months, and \\\\\n- Pain score for the target knee of 4 to 9 points in response to Question 1 of the WOMAC pain index (\"how much pain have you had [in the target knee,\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.7890618163120799,"confidence_rate":0.9999183843425361},{"cnt":[[254,270],[870,270],[870,2499],[254,2499]],"region":{"top_left_x":253,"top_left_y":270,"width":618,"height":2230},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccd2e90d37a0487c8d13ef320c42c73c","type":"table_column","conversion_output":false,"parent_id":"b0c8e72c708b4ef29a7a98b22db5af6b","text":"","text_display":""},{"cnt":[[878,270],[1882,270],[1882,2499],[878,2499]],"region":{"top_left_x":878,"top_left_y":270,"width":1005,"height":2230},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f62891704e944a2bbf4a09ba31500f72","type":"table_column","conversion_output":false,"parent_id":"b0c8e72c708b4ef29a7a98b22db5af6b","text":"","text_display":""},{"cnt":[[229,275],[1888,275],[1888,1552],[229,1552]],"region":{"top_left_x":229,"top_left_y":275,"width":1659,"height":1278},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a3ecea462714374b1fe0ee04e011c16","type":"table_row","conversion_output":false,"parent_id":"b0c8e72c708b4ef29a7a98b22db5af6b","text":"","text_display":""},{"cnt":[[229,1582],[1885,1582],[1885,2499],[229,2499]],"region":{"top_left_x":229,"top_left_y":1582,"width":1657,"height":918},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"491d7fdbbf294372a43087ade4543ea5","type":"table_row","conversion_output":false,"parent_id":"b0c8e72c708b4ef29a7a98b22db5af6b","text":"","text_display":""},{"cnt":[[878,278],[1874,278],[1874,1547],[878,1547]],"region":{"top_left_x":878,"top_left_y":278,"width":997,"height":1269},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4154bee363cc4e82bf6710fce4acc8ef","type":"complex_cell","conversion_output":false,"parent_id":"b0c8e72c708b4ef29a7a98b22db5af6b","children_ids":["3853a3d8cdb74b7191cd5479981c802a","3170059aa26e423da7e33be09f8f7e68","4e32138a179343b297b76cb879e032df","fb88cbb46d0c4711969b96b2bbbb6290","510a13a31100481b97e6f54eec95d426","39240ea1323d4a1f9d81ce7822b07a01","e9c0156f38ae441ebdb2c7e7fc27bcbf","e98ec3ceccfe4bdda948d4a42685e116","7395f5f0a8134f56b0bcb9c392083098","28138f60a7764c169e88b6f6cf62e0ae","52c5c023090749388608f4640a6f6a00","34325cb9b4ee4bd5a07ed7ae354bf9cb","8f8cb06038a64229895d05fe284b1521","3eb409f82dcd4521a81889ddedd4008b","b19b12576eb14f7ca76221cb9ea69a79","1385f98322464443b208b9b7e66234f5","99c283c478f74ce9be5185d9d8039ba8","330eb532f40d416bb61e19be7bbf3029","4a3bfadbd63c41dfb58435f717e88caa","684010369c104e0c87ef3b44ad530d2b","cb111cf7ea28475593d81787082fff1e","d7411eace5384df09a5459d22710f298"],"text":"\\begin{tabular}{l}\ndetermined, beginning at signature of the ICF. During the screening visits, eligibility will be assessed and the target knee will be defined. At the baseline visit, eligibility will be confirmed, randomization will occur, and the first IMP injection will be given (Week 0/Visit 2). The last of the four cycles of 3 injections of IMP will be given on Week 78/Visit 17, and the last dose of IMP is scheduled to be administered at Week 80/Visit 19. \\\\\nTrial visits during the two-year DBPC treatment phase will take place at Weeks 0 (randomization and first IMP injection), \\(1,2,3,12,26,27,28,29,38,52,53,54,55\\), 64, 78, 79, 80, 81, 90, and 104. \\\\\nMajor efficacy assessments will take place on the first day of each treatment cycle and then at the end of the DBPC treatment phase (Week 104/Visit 22). \\\\\nMinor efficacy assessments will take place 9 weeks after each treatment cycle. \\\\\nAEs and concomitant medications will be reviewed and vital signs will be measured at all trial visits. \\\\\nTrial assessments during the 3-year extended follow-up phase will take place at 6 -month intervals from Week 104/Visit 22 through Week 260/Visit 28.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\ndetermined, beginning at signature of the ICF. During the screening visits, eligibility will be assessed and the target knee will be defined. At the baseline visit, eligibility will be confirmed, randomization will occur, and the first IMP injection will be given (Week 0/Visit 2). The last of the four cycles of 3 injections of IMP will be given on Week 78/Visit 17, and the last dose of IMP is scheduled to be administered at Week 80/Visit 19. \\\\\nTrial visits during the two-year DBPC treatment phase will take place at Weeks 0 (randomization and first IMP injection), \\(1,2,3,12,26,27,28,29,38,52,53,54,55\\), 64, 78, 79, 80, 81, 90, and 104. \\\\\nMajor efficacy assessments will take place on the first day of each treatment cycle and then at the end of the DBPC treatment phase (Week 104/Visit 22). \\\\\nMinor efficacy assessments will take place 9 weeks after each treatment cycle. \\\\\nAEs and concomitant medications will be reviewed and vital signs will be measured at all trial visits. \\\\\nTrial assessments during the 3-year extended follow-up phase will take place at 6 -month intervals from Week 104/Visit 22 through Week 260/Visit 28.\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.7890618163120799,"confidence_rate":0.9997602660488898},{"cnt":[[889,286],[1863,286],[1863,333],[889,333]],"region":{"top_left_x":889,"top_left_y":286,"width":975,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3853a3d8cdb74b7191cd5479981c802a","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"determined, beginning at signature of the ICF. During the","text_display":"determined, beginning at signature of the ICF. During the","confidence":1,"confidence_rate":1},{"cnt":[[889,330],[1863,330],[1863,382],[889,382]],"region":{"top_left_x":889,"top_left_y":330,"width":975,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3170059aa26e423da7e33be09f8f7e68","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"screening visits, eligibility will be assessed and the target","text_display":" screening visits, eligibility will be assessed and the target","confidence":1,"confidence_rate":1},{"cnt":[[889,379],[1863,379],[1863,426],[889,426]],"region":{"top_left_x":889,"top_left_y":379,"width":975,"height":47},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e32138a179343b297b76cb879e032df","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"knee will be defined. At the baseline visit, eligibility will","text_display":" knee will be defined. At the baseline visit, eligibility will","confidence":1,"confidence_rate":1},{"cnt":[[887,428],[1863,428],[1863,475],[887,475]],"region":{"top_left_x":886,"top_left_y":428,"width":978,"height":47},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb88cbb46d0c4711969b96b2bbbb6290","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"be confirmed, randomization will occur, and the first IMP","text_display":" be confirmed, randomization will occur, and the first IMP","confidence":1,"confidence_rate":1},{"cnt":[[889,475],[1863,475],[1863,524],[889,524]],"region":{"top_left_x":889,"top_left_y":474,"width":975,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"510a13a31100481b97e6f54eec95d426","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"injection will be given (Week 0/Visit 2). The last of the","text_display":" injection will be given (Week 0/Visit 2). The last of the","confidence":1,"confidence_rate":1},{"cnt":[[889,521],[1863,521],[1863,573],[889,573]],"region":{"top_left_x":889,"top_left_y":521,"width":975,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39240ea1323d4a1f9d81ce7822b07a01","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"four cycles of 3 injections of IMP will be given on Week","text_display":" four cycles of 3 injections of IMP will be given on Week","confidence":1,"confidence_rate":1},{"cnt":[[889,570],[1863,570],[1863,616],[889,616]],"region":{"top_left_x":889,"top_left_y":570,"width":975,"height":47},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9c0156f38ae441ebdb2c7e7fc27bcbf","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"78/Visit 17, and the last dose of IMP is scheduled to be","text_display":" 78/Visit 17, and the last dose of IMP is scheduled to be","confidence":1,"confidence_rate":1},{"cnt":[[889,619],[1465,619],[1465,660],[889,660]],"region":{"top_left_x":889,"top_left_y":619,"width":576,"height":42},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e98ec3ceccfe4bdda948d4a42685e116","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"administered at Week 80/Visit 19.","text_display":" administered at Week 80/Visit 19.","confidence":1,"confidence_rate":1},{"cnt":[[889,709],[1863,709],[1863,758],[889,758]],"region":{"top_left_x":889,"top_left_y":709,"width":975,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7395f5f0a8134f56b0bcb9c392083098","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"Trial visits during the two-year DBPC treatment phase","text_display":"\nTrial visits during the two-year DBPC treatment phase","confidence":1,"confidence_rate":1},{"cnt":[[889,756],[1863,756],[1863,805],[889,805]],"region":{"top_left_x":889,"top_left_y":755,"width":975,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28138f60a7764c169e88b6f6cf62e0ae","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"will take place at Weeks 0 (randomization and first IMP","text_display":" will take place at Weeks 0 (randomization and first IMP","confidence":1,"confidence_rate":1},{"cnt":[[889,805],[1863,805],[1863,851],[889,851]],"region":{"top_left_x":889,"top_left_y":804,"width":975,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52c5c023090749388608f4640a6f6a00","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"injection), \\(1,2,3,12,26,27,28,29,38,52,53,54,55\\),","text_display":" injection), \\(1,2,3,12,26,27,28,29,38,52,53,54,55\\),","confidence":0.7890618163120799,"confidence_rate":0.9958522990176004},{"cnt":[[889,854],[1410,854],[1410,900],[889,900]],"region":{"top_left_x":889,"top_left_y":853,"width":522,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34325cb9b4ee4bd5a07ed7ae354bf9cb","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"64, 78, 79, 80, 81, 90, and 104.","text_display":" 64, 78, 79, 80, 81, 90, and 104.","confidence":0.998046875,"confidence_rate":0.9999456949513558},{"cnt":[[887,941],[1869,941],[1869,990],[887,990]],"region":{"top_left_x":886,"top_left_y":941,"width":983,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f8cb06038a64229895d05fe284b1521","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"Major efficacy assessments will take place on the first","text_display":"\nMajor efficacy assessments will take place on the first","confidence":1,"confidence_rate":1},{"cnt":[[889,990],[1869,990],[1869,1037],[889,1037]],"region":{"top_left_x":889,"top_left_y":990,"width":980,"height":47},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3eb409f82dcd4521a81889ddedd4008b","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"day of each treatment cycle and then at the end of the","text_display":" day of each treatment cycle and then at the end of the","confidence":1,"confidence_rate":1},{"cnt":[[889,1039],[1640,1039],[1640,1086],[889,1086]],"region":{"top_left_x":889,"top_left_y":1039,"width":751,"height":47},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b19b12576eb14f7ca76221cb9ea69a79","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"DBPC treatment phase (Week 104/Visit 22).","text_display":" DBPC treatment phase (Week 104/Visit 22).","confidence":0.99951171875,"confidence_rate":0.9999893826542317},{"cnt":[[887,1127],[1869,1127],[1869,1179],[887,1179]],"region":{"top_left_x":886,"top_left_y":1126,"width":983,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1385f98322464443b208b9b7e66234f5","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"Minor efficacy assessments will take place 9 weeks after","text_display":"\nMinor efficacy assessments will take place 9 weeks after","confidence":0.99951171875,"confidence_rate":0.999992368771335},{"cnt":[[889,1176],[1247,1176],[1247,1222],[889,1222]],"region":{"top_left_x":889,"top_left_y":1175,"width":358,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99c283c478f74ce9be5185d9d8039ba8","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"each treatment cycle.","text_display":" each treatment cycle.","confidence":1,"confidence_rate":1},{"cnt":[[887,1263],[1869,1263],[1869,1309],[887,1309]],"region":{"top_left_x":886,"top_left_y":1263,"width":983,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"330eb532f40d416bb61e19be7bbf3029","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"AEs and concomitant medications will be reviewed and","text_display":"\nAEs and concomitant medications will be reviewed and","confidence":1,"confidence_rate":1},{"cnt":[[889,1312],[1640,1312],[1640,1364],[889,1364]],"region":{"top_left_x":889,"top_left_y":1312,"width":751,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a3bfadbd63c41dfb58435f717e88caa","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"vital signs will be measured at all trial visits.","text_display":" vital signs will be measured at all trial visits.","confidence":1,"confidence_rate":1},{"cnt":[[887,1400],[1869,1400],[1869,1451],[887,1451]],"region":{"top_left_x":886,"top_left_y":1399,"width":983,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"684010369c104e0c87ef3b44ad530d2b","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"Trial assessments during the 3-year extended follow-up","text_display":"\nTrial assessments during the 3-year extended follow-up","confidence":0.9423828125,"confidence_rate":0.9989946801769702},{"cnt":[[889,1449],[1869,1449],[1869,1500],[889,1500]],"region":{"top_left_x":889,"top_left_y":1448,"width":980,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb111cf7ea28475593d81787082fff1e","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"phase will take place at 6 -month intervals from Week","text_display":" phase will take place at 6 -month intervals from Week","confidence":0.99755859375,"confidence_rate":0.999959928813662},{"cnt":[[889,1498],[1577,1498],[1577,1544],[889,1544]],"region":{"top_left_x":889,"top_left_y":1497,"width":688,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7411eace5384df09a5459d22710f298","type":"text","conversion_output":false,"parent_id":"4154bee363cc4e82bf6710fce4acc8ef","text":"104/Visit 22 through Week 260/Visit 28.","text_display":" 104/Visit 22 through Week 260/Visit 28.","confidence":1,"confidence_rate":1},{"cnt":[[262,1585],[859,1585],[859,1683],[262,1683]],"region":{"top_left_x":261,"top_left_y":1585,"width":599,"height":99},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c49348c91d54b5f816adbe538592bee","type":"complex_cell","conversion_output":false,"parent_id":"b0c8e72c708b4ef29a7a98b22db5af6b","children_ids":["8bd18ceaf82a49599833567cfb333f89","977593c50b9441c8934dc1b9da48cc8c"],"text":"Diagnosis and main inclusion and exclusion criteria","text_display":"Diagnosis and main inclusion and exclusion criteria","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[267,1591],[859,1591],[859,1637],[267,1637]],"region":{"top_left_x":267,"top_left_y":1590,"width":593,"height":47},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bd18ceaf82a49599833567cfb333f89","type":"text","conversion_output":false,"parent_id":"0c49348c91d54b5f816adbe538592bee","text":"Diagnosis and main inclusion","text_display":"Diagnosis and main inclusion","confidence":1,"confidence_rate":1},{"cnt":[[267,1640],[657,1640],[657,1681],[267,1681]],"region":{"top_left_x":267,"top_left_y":1639,"width":391,"height":42},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"977593c50b9441c8934dc1b9da48cc8c","type":"text","conversion_output":false,"parent_id":"0c49348c91d54b5f816adbe538592bee","text":"and exclusion criteria","text_display":" and exclusion criteria","confidence":1,"confidence_rate":1},{"cnt":[[884,1585],[1871,1585],[1871,2494],[884,2494]],"region":{"top_left_x":883,"top_left_y":1585,"width":989,"height":909},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dc540e505674d7c9a0f1e994254424d","type":"complex_cell","conversion_output":false,"parent_id":"b0c8e72c708b4ef29a7a98b22db5af6b","children_ids":["397697ccd094410dbe25ea8f9202ea05","57eb7747dd7e4184a4c10bc9a8b531f6","53a79dd158064ad1aaa0cd2a870ad69e","6f2369431f0a4ffa833dae77ef055184","fa380161c6ee42928b72ff31871162ed","17380d55c2284e8ca9e3127306cface7","abea2f6a4af74a5196bfec337d50d94e","6d71fa9e644549dd8f8d73fd2807860c","516a829eef21453d93149b6c59022820","56b43b09a29a43b6a0d795cd342802ab","b343cdf8d655442cb05ba23d255974ca","f731f8ecc53942aab6b3400083759e9a","74262d5c252946dd8591e2f398400e7a","099c07a9755d40549a158c91b382987e","d2f75f9ebcba48d5ab09ef2a25757b3c","8e7ea98eb1914644b1fc71d910a46206","d9d8572da91f46a8a7828fc437e54bfe"],"text":"\\begin{tabular}{l}\nThe trial will enroll adult subjects of either sex with primary femorotibial osteoarthritis according to American College of Rheumatology (ACR) clinical and radiographic criteria who have Kellgren-Lawrence grades of 2 or 3 and a minimum joint space width (JSW) of \\(\\geq 2.5\\) mm in the medial compartment. \\\\\nSubjects must have pain in the target knee on most days and/or require symptomatic treatment of knee pain with paracetamol (acetaminophen), systemic non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 selective inhibitor (coxibs), or tramadol on most days of the previous month, and must have both: \\\\\n- A history of pain due to OA in the target knee for at least 6 months, and \\\\\n- Pain score for the target knee of 4 to 9 points in response to Question 1 of the WOMAC pain index (\"how much pain have you had [in the target knee,\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nThe trial will enroll adult subjects of either sex with primary femorotibial osteoarthritis according to American College of Rheumatology (ACR) clinical and radiographic criteria who have Kellgren-Lawrence grades of 2 or 3 and a minimum joint space width (JSW) of \\(\\geq 2.5\\) mm in the medial compartment. \\\\\nSubjects must have pain in the target knee on most days and/or require symptomatic treatment of knee pain with paracetamol (acetaminophen), systemic non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 selective inhibitor (coxibs), or tramadol on most days of the previous month, and must have both: \\\\\n- A history of pain due to OA in the target knee for at least 6 months, and \\\\\n- Pain score for the target knee of 4 to 9 points in response to Question 1 of the WOMAC pain index (\"how much pain have you had [in the target knee,\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9999949057402544},{"cnt":[[887,1591],[1863,1591],[1863,1637],[887,1637]],"region":{"top_left_x":886,"top_left_y":1590,"width":978,"height":47},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"397697ccd094410dbe25ea8f9202ea05","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"The trial will enroll adult subjects of either sex with","text_display":"The trial will enroll adult subjects of either sex with","confidence":1,"confidence_rate":1},{"cnt":[[887,1640],[1863,1640],[1863,1686],[887,1686]],"region":{"top_left_x":886,"top_left_y":1639,"width":978,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57eb7747dd7e4184a4c10bc9a8b531f6","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"primary femorotibial osteoarthritis according to","text_display":" primary femorotibial osteoarthritis according to","confidence":1,"confidence_rate":1},{"cnt":[[887,1683],[1869,1683],[1869,1735],[887,1735]],"region":{"top_left_x":886,"top_left_y":1683,"width":983,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53a79dd158064ad1aaa0cd2a870ad69e","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"American College of Rheumatology (ACR) clinical and","text_display":" American College of Rheumatology (ACR) clinical and","confidence":1,"confidence_rate":1},{"cnt":[[887,1732],[1869,1732],[1869,1782],[887,1782]],"region":{"top_left_x":886,"top_left_y":1732,"width":983,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f2369431f0a4ffa833dae77ef055184","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"radiographic criteria who have Kellgren-Lawrence grades","text_display":" radiographic criteria who have Kellgren-Lawrence grades","confidence":1,"confidence_rate":1},{"cnt":[[889,1782],[1869,1782],[1869,1828],[889,1828]],"region":{"top_left_x":889,"top_left_y":1781,"width":980,"height":47},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa380161c6ee42928b72ff31871162ed","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"of 2 or 3 and a minimum joint space width (JSW) of \\(\\geq 2.5\\)","text_display":" of 2 or 3 and a minimum joint space width (JSW) of \\(\\geq 2.5\\)","confidence":1,"confidence_rate":1},{"cnt":[[887,1831],[1427,1831],[1427,1877],[887,1877]],"region":{"top_left_x":886,"top_left_y":1830,"width":541,"height":47},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17380d55c2284e8ca9e3127306cface7","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"mm in the medial compartment.","text_display":" mm in the medial compartment.","confidence":1,"confidence_rate":1},{"cnt":[[889,1918],[1863,1918],[1863,1967],[889,1967]],"region":{"top_left_x":889,"top_left_y":1917,"width":975,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abea2f6a4af74a5196bfec337d50d94e","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"Subjects must have pain in the target knee on most days","text_display":"\nSubjects must have pain in the target knee on most days","confidence":1,"confidence_rate":1},{"cnt":[[889,1967],[1869,1967],[1869,2013],[889,2013]],"region":{"top_left_x":889,"top_left_y":1967,"width":980,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d71fa9e644549dd8f8d73fd2807860c","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"and/or require symptomatic treatment of knee pain with","text_display":" and/or require symptomatic treatment of knee pain with","confidence":1,"confidence_rate":1},{"cnt":[[887,2016],[1869,2016],[1869,2063],[887,2063]],"region":{"top_left_x":886,"top_left_y":2016,"width":983,"height":47},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"516a829eef21453d93149b6c59022820","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"paracetamol (acetaminophen), systemic non-steroidal","text_display":" paracetamol (acetaminophen), systemic non-steroidal","confidence":1,"confidence_rate":1},{"cnt":[[887,2063],[1869,2063],[1869,2112],[887,2112]],"region":{"top_left_x":886,"top_left_y":2062,"width":983,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56b43b09a29a43b6a0d795cd342802ab","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"anti-inflammatory drugs (NSAIDs) including COX-2","text_display":" anti-inflammatory drugs (NSAIDs) including COX-2","confidence":1,"confidence_rate":1},{"cnt":[[887,2109],[1871,2109],[1871,2158],[887,2158]],"region":{"top_left_x":886,"top_left_y":2108,"width":986,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b343cdf8d655442cb05ba23d255974ca","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"selective inhibitor (coxibs), or tramadol on most days of","text_display":" selective inhibitor (coxibs), or tramadol on most days of","confidence":0.99951171875,"confidence_rate":0.999992122603638},{"cnt":[[887,2158],[1574,2158],[1574,2204],[887,2204]],"region":{"top_left_x":886,"top_left_y":2158,"width":689,"height":47},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f731f8ecc53942aab6b3400083759e9a","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"the previous month, and must have both:","text_display":" the previous month, and must have both:","confidence":1,"confidence_rate":1},{"cnt":[[887,2229],[1869,2229],[1869,2281],[887,2281]],"region":{"top_left_x":886,"top_left_y":2228,"width":983,"height":53},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74262d5c252946dd8591e2f398400e7a","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"- A history of pain due to OA in the target knee for at","text_display":"\n- A history of pain due to OA in the target knee for at","confidence":0.99853515625,"confidence_rate":0.999975568337083},{"cnt":[[936,2278],[1268,2278],[1268,2324],[936,2324]],"region":{"top_left_x":935,"top_left_y":2278,"width":334,"height":47},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"099c07a9755d40549a158c91b382987e","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"least 6 months, and","text_display":" least 6 months, and","confidence":0.99853515625,"confidence_rate":0.9999457082263518},{"cnt":[[889,2349],[1869,2349],[1869,2398],[889,2398]],"region":{"top_left_x":889,"top_left_y":2348,"width":980,"height":51},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2f75f9ebcba48d5ab09ef2a25757b3c","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"- Pain score for the target knee of 4 to 9 points in","text_display":"\n- Pain score for the target knee of 4 to 9 points in","confidence":1,"confidence_rate":1},{"cnt":[[936,2398],[1869,2398],[1869,2444],[936,2444]],"region":{"top_left_x":935,"top_left_y":2398,"width":934,"height":47},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e7ea98eb1914644b1fc71d910a46206","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"response to Question 1 of the WOMAC pain index","text_display":" response to Question 1 of the WOMAC pain index","confidence":1,"confidence_rate":1},{"cnt":[[938,2444],[1869,2444],[1869,2494],[938,2494]],"region":{"top_left_x":938,"top_left_y":2444,"width":931,"height":50},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9d8572da91f46a8a7828fc437e54bfe","type":"text","conversion_output":false,"parent_id":"9dc540e505674d7c9a0f1e994254424d","text":"(\"how much pain have you had [in the target knee,","text_display":" (\"how much pain have you had [in the target knee,","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":53,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b32052b26ecf414d94afbad8de1928e3","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2545],[389,2543],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2542,"width":146,"height":45},"line":54,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0affe95aa66d48b596b84117ba474581","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1506,2531],[1601,2531],[1601,2563],[1506,2563]],"region":{"top_left_x":1506,"top_left_y":2530,"width":95,"height":34},"line":55,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d6ba82592dff45ce97964b605cf6f025","type":"page_info","conversion_output":false,"text":"20/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-021","page":21,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2039309a8ccf442e885a6754d8b92d55","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f348abc7cc4480e9a52ca4913981f2b","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9e4a06f7e95477bb28d36ba1d15faaa","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,275],[1886,275],[1886,2501],[243,2501]],"region":{"top_left_x":242,"top_left_y":275,"width":1645,"height":2226},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"384b3462501e4df7a20bfd14b5df23c2","type":"table","conversion_output":true,"children_ids":["9be95a82a9e34cd6b6aaa7486999f90b","6af2957e2d414fda834a537f70d93b9b","61d717b8887b4e0b9ef6aff1df3f5dad","152cc7541df44ad6ab2200685b95b101","bf27eff172064e7380ada9be6152e5d2","a1d7cc626dec457aa2d321f7543bd4ac","27b858cc9d39411495f4a7d7d841a8cb"],"text":"\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\nWomen of childbearing potential must use a form of contraception with a failure rate of less than 1\\% per year throughout the trial. \\\\\nMain exclusion criteria are malalignment of \\(>5\\) degrees in the femorotibial axis of the target knee, clinical signs of inflammation (i.e., redness) in the target knee, i.a. administration of corticosteroids or hyaluronic acid into either knee within 6 months before screening, any plan for knee surgery (affecting either the target or the contralateral knee) within the next two years, concomitant conditions or treatments deemed to be incompatible with trial participation, contraindications to MRI scanning (including inability to fit in the scanner or knee coil), pregnancy or breastfeeding, participation in another clinical trial within the past 30 days, and legal incapacity or limited legal capacity. \\\\\nFull lists of inclusion and exclusion criteria are presented in Sections 5.3.1 and 5.3.2, respectively. \\\\\nWritten informed consent must be obtained prior to any trial-related activity.\n\\end{tabular} \\\\\n\\hline Investigational Medicinal Product: dose/mode of administration/ dosing schedule & \\begin{tabular}{l}\nSprifermin (rhFGF-18) 30 mcg or 100 mcg , administered intra-articularly. \\\\\nSubjects will receive 4 cycles of treatment (each consisting of 3 once-weekly i.a. injections over 3 consecutive weeks) at intervals of 6 months. \\\\\nSubjects will be randomized in equal allocation to one of 5 treatment groups: \\\\\n- 4 cycles of sprifermin ( 100 mcg per injection) \\\\\n- 2 cycles of sprifermin ( 100 mcg per injection) alternating with 2 cycles of placebo \\\\\n- 4 cycles of sprifermin ( 30 mcg per injection) \\\\\n- 2 cycles of sprifermin ( 30 mcg per injection) alternating with 2 cycles of placebo \\\\\n- 4 cycles of placebo (see below)\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\nWomen of childbearing potential must use a form of contraception with a failure rate of less than 1\\% per year throughout the trial. \\\\\nMain exclusion criteria are malalignment of \\(>5\\) degrees in the femorotibial axis of the target knee, clinical signs of inflammation (i.e., redness) in the target knee, i.a. administration of corticosteroids or hyaluronic acid into either knee within 6 months before screening, any plan for knee surgery (affecting either the target or the contralateral knee) within the next two years, concomitant conditions or treatments deemed to be incompatible with trial participation, contraindications to MRI scanning (including inability to fit in the scanner or knee coil), pregnancy or breastfeeding, participation in another clinical trial within the past 30 days, and legal incapacity or limited legal capacity. \\\\\nFull lists of inclusion and exclusion criteria are presented in Sections 5.3.1 and 5.3.2, respectively. \\\\\nWritten informed consent must be obtained prior to any trial-related activity.\n\\end{tabular} \\\\\n\\hline Investigational Medicinal Product: dose/mode of administration/ dosing schedule & \\begin{tabular}{l}\nSprifermin (rhFGF-18) 30 mcg or 100 mcg , administered intra-articularly. \\\\\nSubjects will receive 4 cycles of treatment (each consisting of 3 once-weekly i.a. injections over 3 consecutive weeks) at intervals of 6 months. \\\\\nSubjects will be randomized in equal allocation to one of 5 treatment groups: \\\\\n- 4 cycles of sprifermin ( 100 mcg per injection) \\\\\n- 2 cycles of sprifermin ( 100 mcg per injection) alternating with 2 cycles of placebo \\\\\n- 4 cycles of sprifermin ( 30 mcg per injection) \\\\\n- 2 cycles of sprifermin ( 30 mcg per injection) alternating with 2 cycles of placebo \\\\\n- 4 cycles of placebo (see below)\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.5849609375,"confidence_rate":0.9996961280357946},{"cnt":[[256,275],[848,275],[848,2501],[256,2501]],"region":{"top_left_x":255,"top_left_y":275,"width":593,"height":2227},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9be95a82a9e34cd6b6aaa7486999f90b","type":"table_column","conversion_output":false,"parent_id":"384b3462501e4df7a20bfd14b5df23c2","text":"","text_display":""},{"cnt":[[870,275],[1884,275],[1884,2501],[870,2501]],"region":{"top_left_x":869,"top_left_y":275,"width":1016,"height":2227},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6af2957e2d414fda834a537f70d93b9b","type":"table_column","conversion_output":false,"parent_id":"384b3462501e4df7a20bfd14b5df23c2","text":"","text_display":""},{"cnt":[[242,275],[1887,275],[1887,1656],[242,1656]],"region":{"top_left_x":242,"top_left_y":275,"width":1646,"height":1381},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61d717b8887b4e0b9ef6aff1df3f5dad","type":"table_row","conversion_output":false,"parent_id":"384b3462501e4df7a20bfd14b5df23c2","text":"","text_display":""},{"cnt":[[242,1683],[1887,1683],[1887,2499],[242,2499]],"region":{"top_left_x":242,"top_left_y":1682,"width":1646,"height":817},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"152cc7541df44ad6ab2200685b95b101","type":"table_row","conversion_output":false,"parent_id":"384b3462501e4df7a20bfd14b5df23c2","text":"","text_display":""},{"cnt":[[880,1647],[883,560],[1885,563],[1882,1650]],"region":{"top_left_x":880,"top_left_y":560,"width":1005,"height":1091},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf27eff172064e7380ada9be6152e5d2","type":"complex_cell","conversion_output":false,"parent_id":"384b3462501e4df7a20bfd14b5df23c2","children_ids":["e38fa665a2b44e90af2ee1911da1dc98","1fe08ef9f886418886374e5fe88adbe4","994b68fa17e34346b4feb6d3ac657e3b","ba8845f3f1bb4363b2168d2513c579aa","a9288c1c438949ccad2600769c3ccafb","a74e5c94920e4f6d812dd4cc6829ce82","f30b049cb5b94c26b2039e2ff5de8896","b61d0d904c5c4f248ae827571a2ab024","d8c1ab44187f4655b0af265b50388ab0","9fd03c1ec714442cb48e807ef7e7d7c8","324eec52e9f64c61b54cc240aff61e21","9a3c4b31bcef41e894a3a6a230dc9345","1dae7b7c678843ea9ec4ec3a458cb746","41cf7b20057846a187d51decd70fe10c","8e00cfa08e86467e8bf2cc49ea413404","cee6deedba0140e1b47eb95d10f8b1a4","e3fee14c68644a8aa3efe1e581ea25dd","8e9f0e9b24e842489d7c629a5612b9ea","b63a2153f4b140849af194829d0a532d","7d6c00aa2b014b46b0d1d3b6d1f089ad"],"text":"\\begin{tabular}{l}\nWomen of childbearing potential must use a form of contraception with a failure rate of less than 1\\% per year throughout the trial. \\\\\nMain exclusion criteria are malalignment of \\(>5\\) degrees in the femorotibial axis of the target knee, clinical signs of inflammation (i.e., redness) in the target knee, i.a. administration of corticosteroids or hyaluronic acid into either knee within 6 months before screening, any plan for knee surgery (affecting either the target or the contralateral knee) within the next two years, concomitant conditions or treatments deemed to be incompatible with trial participation, contraindications to MRI scanning (including inability to fit in the scanner or knee coil), pregnancy or breastfeeding, participation in another clinical trial within the past 30 days, and legal incapacity or limited legal capacity. \\\\\nFull lists of inclusion and exclusion criteria are presented in Sections 5.3.1 and 5.3.2, respectively. \\\\\nWritten informed consent must be obtained prior to any trial-related activity.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nWomen of childbearing potential must use a form of contraception with a failure rate of less than 1\\% per year throughout the trial. \\\\\nMain exclusion criteria are malalignment of \\(>5\\) degrees in the femorotibial axis of the target knee, clinical signs of inflammation (i.e., redness) in the target knee, i.a. administration of corticosteroids or hyaluronic acid into either knee within 6 months before screening, any plan for knee surgery (affecting either the target or the contralateral knee) within the next two years, concomitant conditions or treatments deemed to be incompatible with trial participation, contraindications to MRI scanning (including inability to fit in the scanner or knee coil), pregnancy or breastfeeding, participation in another clinical trial within the past 30 days, and legal incapacity or limited legal capacity. \\\\\nFull lists of inclusion and exclusion criteria are presented in Sections 5.3.1 and 5.3.2, respectively. \\\\\nWritten informed consent must be obtained prior to any trial-related activity.\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.5849609375,"confidence_rate":0.9995419008520666},{"cnt":[[889,564],[1871,564],[1871,611],[889,611]],"region":{"top_left_x":888,"top_left_y":564,"width":983,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e38fa665a2b44e90af2ee1911da1dc98","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"Women of childbearing potential must use a form of","text_display":"Women of childbearing potential must use a form of","confidence":0.998046875,"confidence_rate":0.999964454543831},{"cnt":[[886,613],[1865,613],[1865,660],[886,660]],"region":{"top_left_x":885,"top_left_y":613,"width":981,"height":47},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fe08ef9f886418886374e5fe88adbe4","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"contraception with a failure rate of less than 1\\% per year","text_display":" contraception with a failure rate of less than 1\\% per year","confidence":0.970703125,"confidence_rate":0.9995281336029842},{"cnt":[[886,662],[1227,662],[1227,709],[886,709]],"region":{"top_left_x":885,"top_left_y":662,"width":342,"height":47},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"994b68fa17e34346b4feb6d3ac657e3b","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"throughout the trial.","text_display":" throughout the trial.","confidence":1,"confidence_rate":1},{"cnt":[[886,750],[1865,750],[1865,796],[886,796]],"region":{"top_left_x":885,"top_left_y":749,"width":981,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba8845f3f1bb4363b2168d2513c579aa","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"Main exclusion criteria are malalignment of \\(>5\\) degrees","text_display":"\nMain exclusion criteria are malalignment of \\(>5\\) degrees","confidence":0.5849609375,"confidence_rate":0.9913887394077079},{"cnt":[[886,799],[1863,799],[1863,845],[886,845]],"region":{"top_left_x":885,"top_left_y":798,"width":978,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9288c1c438949ccad2600769c3ccafb","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"in the femorotibial axis of the target knee, clinical signs","text_display":" in the femorotibial axis of the target knee, clinical signs","confidence":1,"confidence_rate":1},{"cnt":[[889,848],[1860,848],[1860,894],[889,894]],"region":{"top_left_x":888,"top_left_y":847,"width":972,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a74e5c94920e4f6d812dd4cc6829ce82","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"of inflammation (i.e., redness) in the target knee, i.a.","text_display":" of inflammation (i.e., redness) in the target knee, i.a.","confidence":0.99951171875,"confidence_rate":0.9999919934665097},{"cnt":[[886,897],[1865,897],[1865,941],[886,941]],"region":{"top_left_x":885,"top_left_y":897,"width":981,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f30b049cb5b94c26b2039e2ff5de8896","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"administration of corticosteroids or hyaluronic acid into","text_display":" administration of corticosteroids or hyaluronic acid into","confidence":1,"confidence_rate":1},{"cnt":[[889,943],[1865,943],[1865,987],[889,987]],"region":{"top_left_x":888,"top_left_y":943,"width":978,"height":45},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b61d0d904c5c4f248ae827571a2ab024","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"either knee within 6 months before screening, any plan","text_display":" either knee within 6 months before screening, any plan","confidence":1,"confidence_rate":1},{"cnt":[[889,990],[1865,990],[1865,1036],[889,1036]],"region":{"top_left_x":888,"top_left_y":989,"width":978,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8c1ab44187f4655b0af265b50388ab0","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"for knee surgery (affecting either the target or the","text_display":" for knee surgery (affecting either the target or the","confidence":1,"confidence_rate":1},{"cnt":[[889,1039],[1863,1039],[1863,1085],[889,1085]],"region":{"top_left_x":888,"top_left_y":1038,"width":975,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fd03c1ec714442cb48e807ef7e7d7c8","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"contralateral knee) within the next two years,","text_display":" contralateral knee) within the next two years,","confidence":1,"confidence_rate":1},{"cnt":[[886,1088],[1865,1088],[1865,1129],[886,1129]],"region":{"top_left_x":885,"top_left_y":1088,"width":981,"height":41},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"324eec52e9f64c61b54cc240aff61e21","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"concomitant conditions or treatments deemed to be","text_display":" concomitant conditions or treatments deemed to be","confidence":1,"confidence_rate":1},{"cnt":[[889,1134],[1865,1134],[1865,1181],[889,1181]],"region":{"top_left_x":888,"top_left_y":1134,"width":978,"height":47},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a3c4b31bcef41e894a3a6a230dc9345","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"incompatible with trial participation, contraindications to","text_display":" incompatible with trial participation, contraindications to","confidence":1,"confidence_rate":1},{"cnt":[[886,1184],[1865,1184],[1865,1227],[886,1227]],"region":{"top_left_x":885,"top_left_y":1183,"width":981,"height":45},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1dae7b7c678843ea9ec4ec3a458cb746","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"MRI scanning (including inability to fit in the scanner or","text_display":" MRI scanning (including inability to fit in the scanner or","confidence":1,"confidence_rate":1},{"cnt":[[886,1230],[1865,1230],[1865,1276],[886,1276]],"region":{"top_left_x":885,"top_left_y":1229,"width":981,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41cf7b20057846a187d51decd70fe10c","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"knee coil), pregnancy or breastfeeding, participation in","text_display":" knee coil), pregnancy or breastfeeding, participation in","confidence":1,"confidence_rate":1},{"cnt":[[886,1279],[1865,1279],[1865,1325],[886,1325]],"region":{"top_left_x":885,"top_left_y":1279,"width":981,"height":47},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e00cfa08e86467e8bf2cc49ea413404","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"another clinical trial within the past 30 days, and legal","text_display":" another clinical trial within the past 30 days, and legal","confidence":1,"confidence_rate":1},{"cnt":[[886,1328],[1489,1328],[1489,1375],[886,1375]],"region":{"top_left_x":885,"top_left_y":1328,"width":604,"height":47},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cee6deedba0140e1b47eb95d10f8b1a4","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"incapacity or limited legal capacity.","text_display":" incapacity or limited legal capacity.","confidence":1,"confidence_rate":1},{"cnt":[[886,1415],[1865,1415],[1865,1462],[886,1462]],"region":{"top_left_x":885,"top_left_y":1415,"width":981,"height":47},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3fee14c68644a8aa3efe1e581ea25dd","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"Full lists of inclusion and exclusion criteria are presented","text_display":"\nFull lists of inclusion and exclusion criteria are presented","confidence":1,"confidence_rate":1},{"cnt":[[886,1465],[1568,1465],[1568,1511],[886,1511]],"region":{"top_left_x":885,"top_left_y":1464,"width":683,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e9f0e9b24e842489d7c629a5612b9ea","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"in Sections 5.3.1 and 5.3.2, respectively.","text_display":" in Sections 5.3.1 and 5.3.2, respectively.","confidence":1,"confidence_rate":1},{"cnt":[[886,1552],[1865,1552],[1865,1601],[886,1601]],"region":{"top_left_x":885,"top_left_y":1551,"width":981,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b63a2153f4b140849af194829d0a532d","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"Written informed consent must be obtained prior to any","text_display":"\nWritten informed consent must be obtained prior to any","confidence":1,"confidence_rate":1},{"cnt":[[886,1601],[1232,1601],[1232,1647],[886,1647]],"region":{"top_left_x":885,"top_left_y":1600,"width":348,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d6c00aa2b014b46b0d1d3b6d1f089ad","type":"text","conversion_output":false,"parent_id":"bf27eff172064e7380ada9be6152e5d2","text":"trial-related activity.","text_display":" trial-related activity.","confidence":1,"confidence_rate":1},{"cnt":[[258,1688],[845,1688],[845,1838],[258,1838]],"region":{"top_left_x":258,"top_left_y":1688,"width":587,"height":151},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1d7cc626dec457aa2d321f7543bd4ac","type":"complex_cell","conversion_output":false,"parent_id":"384b3462501e4df7a20bfd14b5df23c2","children_ids":["5ee29025f3d44c5990ad5f749eb52122","fd0458a0148f4bc79cd2dea8181316b1","12984a47919442f7b340d72f20566503"],"text":"Investigational Medicinal Product: dose/mode of administration/ dosing schedule","text_display":"Investigational Medicinal Product: dose/mode of administration/ dosing schedule","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,1694],[725,1694],[725,1740],[264,1740]],"region":{"top_left_x":263,"top_left_y":1693,"width":462,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ee29025f3d44c5990ad5f749eb52122","type":"text","conversion_output":false,"parent_id":"a1d7cc626dec457aa2d321f7543bd4ac","text":"Investigational Medicinal","text_display":"Investigational Medicinal","confidence":1,"confidence_rate":1},{"cnt":[[264,1743],[681,1743],[681,1784],[264,1784]],"region":{"top_left_x":263,"top_left_y":1742,"width":419,"height":42},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd0458a0148f4bc79cd2dea8181316b1","type":"text","conversion_output":false,"parent_id":"a1d7cc626dec457aa2d321f7543bd4ac","text":"Product: dose/mode of","text_display":" Product: dose/mode of","confidence":1,"confidence_rate":1},{"cnt":[[264,1787],[840,1787],[840,1838],[264,1838]],"region":{"top_left_x":263,"top_left_y":1786,"width":577,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12984a47919442f7b340d72f20566503","type":"text","conversion_output":false,"parent_id":"a1d7cc626dec457aa2d321f7543bd4ac","text":"administration/ dosing schedule","text_display":" administration/ dosing schedule","confidence":1,"confidence_rate":1},{"cnt":[[883,1688],[1871,1688],[1871,2496],[883,2496]],"region":{"top_left_x":883,"top_left_y":1688,"width":988,"height":808},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27b858cc9d39411495f4a7d7d841a8cb","type":"complex_cell","conversion_output":false,"parent_id":"384b3462501e4df7a20bfd14b5df23c2","children_ids":["82845f7821a34c5a9de8a731e0b4a01b","405403a0acee4421898a96a6e8f228f5","e2d8862fbd70478d884fd8eca1da969e","27121120f9224f238362ac0c5cfc977c","2f460f68fb3d47bc8697e9d9e4b90d1e","1ba9d9811404482d9cc7be2cb22d0ef9","7d8d7e0fca1742c3b113afccf3440c71","c1b156a572084b8394f2d121f27dcfc7","f8b7f3bc67744d7fb0720c4d61bb45d4","483e7e6687674aac962e9cb26975cf83","84d34242573b415aac3f12448fba3ed5","bee084fdb4ab4bdc836845a9ee2b8d3a","48547180b82140c19bdd00a8e661f537","521bca07ad7f4f41a7e0b4ff7a4a2047"],"text":"\\begin{tabular}{l}\nSprifermin (rhFGF-18) 30 mcg or 100 mcg , administered intra-articularly. \\\\\nSubjects will receive 4 cycles of treatment (each consisting of 3 once-weekly i.a. injections over 3 consecutive weeks) at intervals of 6 months. \\\\\nSubjects will be randomized in equal allocation to one of 5 treatment groups: \\\\\n- 4 cycles of sprifermin ( 100 mcg per injection) \\\\\n- 2 cycles of sprifermin ( 100 mcg per injection) alternating with 2 cycles of placebo \\\\\n- 4 cycles of sprifermin ( 30 mcg per injection) \\\\\n- 2 cycles of sprifermin ( 30 mcg per injection) alternating with 2 cycles of placebo \\\\\n- 4 cycles of placebo (see below)\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nSprifermin (rhFGF-18) 30 mcg or 100 mcg , administered intra-articularly. \\\\\nSubjects will receive 4 cycles of treatment (each consisting of 3 once-weekly i.a. injections over 3 consecutive weeks) at intervals of 6 months. \\\\\nSubjects will be randomized in equal allocation to one of 5 treatment groups: \\\\\n- 4 cycles of sprifermin ( 100 mcg per injection) \\\\\n- 2 cycles of sprifermin ( 100 mcg per injection) alternating with 2 cycles of placebo \\\\\n- 4 cycles of sprifermin ( 30 mcg per injection) \\\\\n- 2 cycles of sprifermin ( 30 mcg per injection) alternating with 2 cycles of placebo \\\\\n- 4 cycles of placebo (see below)\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.7054561600089073,"confidence_rate":0.9995465525178647},{"cnt":[[886,1694],[1865,1694],[1865,1740],[886,1740]],"region":{"top_left_x":885,"top_left_y":1693,"width":981,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82845f7821a34c5a9de8a731e0b4a01b","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"Sprifermin (rhFGF-18) 30 mcg or 100 mcg , administered","text_display":"Sprifermin (rhFGF-18) 30 mcg or 100 mcg , administered","confidence":0.9990234375,"confidence_rate":0.9999858401053562},{"cnt":[[886,1743],[1164,1743],[1164,1789],[886,1789]],"region":{"top_left_x":885,"top_left_y":1742,"width":280,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"405403a0acee4421898a96a6e8f228f5","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"intra-articularly.","text_display":" intra-articularly.","confidence":1,"confidence_rate":1},{"cnt":[[889,1830],[1865,1830],[1865,1877],[889,1877]],"region":{"top_left_x":888,"top_left_y":1830,"width":978,"height":47},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2d8862fbd70478d884fd8eca1da969e","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"Subjects will receive 4 cycles of treatment (each","text_display":"\nSubjects will receive 4 cycles of treatment (each","confidence":1,"confidence_rate":1},{"cnt":[[889,1879],[1863,1879],[1863,1926],[889,1926]],"region":{"top_left_x":888,"top_left_y":1879,"width":975,"height":47},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27121120f9224f238362ac0c5cfc977c","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"consisting of 3 once-weekly i.a. injections over 3","text_display":" consisting of 3 once-weekly i.a. injections over 3","confidence":1,"confidence_rate":1},{"cnt":[[886,1926],[1633,1926],[1633,1972],[886,1972]],"region":{"top_left_x":885,"top_left_y":1925,"width":749,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f460f68fb3d47bc8697e9d9e4b90d1e","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"consecutive weeks) at intervals of 6 months.","text_display":" consecutive weeks) at intervals of 6 months.","confidence":1,"confidence_rate":1},{"cnt":[[886,2016],[1871,2016],[1871,2062],[886,2062]],"region":{"top_left_x":885,"top_left_y":2015,"width":986,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ba9d9811404482d9cc7be2cb22d0ef9","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"Subjects will be randomized in equal allocation to one of","text_display":"\nSubjects will be randomized in equal allocation to one of","confidence":1,"confidence_rate":1},{"cnt":[[886,2065],[1216,2065],[1216,2111],[886,2111]],"region":{"top_left_x":885,"top_left_y":2064,"width":332,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d8d7e0fca1742c3b113afccf3440c71","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"5 treatment groups:","text_display":" 5 treatment groups:","confidence":1,"confidence_rate":1},{"cnt":[[889,2119],[1713,2119],[1713,2171],[889,2171]],"region":{"top_left_x":888,"top_left_y":2119,"width":825,"height":53},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1b156a572084b8394f2d121f27dcfc7","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"- 4 cycles of sprifermin ( 100 mcg per injection)","text_display":"\n- 4 cycles of sprifermin ( 100 mcg per injection)","confidence":0.9892628192901611,"confidence_rate":0.9998258983799382},{"cnt":[[889,2179],[1865,2179],[1865,2226],[889,2226]],"region":{"top_left_x":888,"top_left_y":2179,"width":978,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8b7f3bc67744d7fb0720c4d61bb45d4","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"- 2 cycles of sprifermin ( 100 mcg per injection)","text_display":"\n- 2 cycles of sprifermin ( 100 mcg per injection)","confidence":0.9907393455505371,"confidence_rate":0.999849949953914},{"cnt":[[935,2228],[1538,2228],[1538,2275],[935,2275]],"region":{"top_left_x":934,"top_left_y":2228,"width":604,"height":47},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"483e7e6687674aac962e9cb26975cf83","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"alternating with 2 cycles of placebo","text_display":" alternating with 2 cycles of placebo","confidence":0.99951171875,"confidence_rate":0.9999889000502843},{"cnt":[[889,2283],[1691,2283],[1691,2335],[889,2335]],"region":{"top_left_x":888,"top_left_y":2283,"width":803,"height":52},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84d34242573b415aac3f12448fba3ed5","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"- 4 cycles of sprifermin ( 30 mcg per injection)","text_display":"\n- 4 cycles of sprifermin ( 30 mcg per injection)","confidence":0.7054561600089073,"confidence_rate":0.9942964804585454},{"cnt":[[889,2343],[1865,2343],[1865,2389],[889,2389]],"region":{"top_left_x":888,"top_left_y":2343,"width":978,"height":47},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bee084fdb4ab4bdc836845a9ee2b8d3a","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"- 2 cycles of sprifermin ( 30 mcg per injection)","text_display":"\n- 2 cycles of sprifermin ( 30 mcg per injection)","confidence":0.9844207763671875,"confidence_rate":0.9997426256662418},{"cnt":[[935,2392],[1538,2392],[1538,2439],[935,2439]],"region":{"top_left_x":934,"top_left_y":2392,"width":604,"height":47},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48547180b82140c19bdd00a8e661f537","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"alternating with 2 cycles of placebo","text_display":" alternating with 2 cycles of placebo","confidence":0.99951171875,"confidence_rate":0.9999889000502843},{"cnt":[[886,2447],[1467,2447],[1467,2496],[886,2496]],"region":{"top_left_x":885,"top_left_y":2446,"width":583,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"521bca07ad7f4f41a7e0b4ff7a4a2047","type":"text","conversion_output":false,"parent_id":"27b858cc9d39411495f4a7d7d841a8cb","text":"- 4 cycles of placebo (see below)","text_display":"\n- 4 cycles of placebo (see below)","confidence":0.99951171875,"confidence_rate":0.9999880878636791},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":49,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c93b60c1a97a4907aa6b7eb6e6635b29","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2546],[389,2543],[390,2586],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":146,"height":47},"line":50,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3a1b447bb0aa4722bb6831e7ce29c6b5","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968649},{"cnt":[[1504,2522],[1601,2522],[1601,2563],[1504,2563]],"region":{"top_left_x":1503,"top_left_y":2522,"width":98,"height":42},"line":51,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"534ad765a6c84e74857758130f414caa","type":"page_info","conversion_output":false,"text":"21/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-022","page":22,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe57efe0f34c489c8724cd74d04e9488","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[640,125],[1317,125],[1317,174],[640,174]],"region":{"top_left_x":640,"top_left_y":124,"width":677,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6a229513847455a9c6fed973f1912d2","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3894d7bea264991bd0d6048f9fe951a","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,271],[1886,271],[1886,2475],[243,2475]],"region":{"top_left_x":242,"top_left_y":270,"width":1645,"height":2205},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dbda5d8b40949bba4428ea7620c597f","type":"table","conversion_output":true,"children_ids":["d600c45f766d4c79818a9ccd67acf0a8","b67cb2c615854411b4d44ed0ede5e0c4","58ab9a2901d44e20becbc21e55e68832","c14057e2c406457ea6305d65123173be","efa38a1c1aa040bcb53c8060f2f3b8d6","57d7e5926a3b49d49bbf1956e0ca102f","027f5b4dbee947e8bed125b89198d844","9404124aac354bd89ef65393020814d2","4e93ce69b6914920bcab630f8e688d38","2fa844eaae0c4d798813d3197ef79c89","625cd00f20a4441ab86de7c2394a4ddd","15a2099188584063b3ce6d6e34b32a92","01d5d93825fe41c2b7871e11307bafb5","904fc41210bf488996263fa91d34819c","05eceadab338461ba63b538fcd54ca30","38a844260998404a8611de419254c9af","898bb35a7e5846f188ea80693217be30"],"text":"\\begin{tabular}{|l|l|}\n\\hline Reference therapy: dose/mode of administration/dosing schedule & Placebo to match sprifermin, administered i.a. (see treatment regimen described above for sprifermin) \\\\\n\\hline Planned treatment duration per subject & 2 years \\\\\n\\hline Primary endpoint & Change from baseline in cartilage thickness in the total femorotibial joint as evaluated by MRI at 2 years \\\\\n\\hline Secondary endpoints & \\begin{tabular}{l}\n- Changes from baseline in the WOMAC total score and in the WOMAC pain, function, and stiffness index scores over 2 years \\\\\n- Change from baseline in the 20 -meter walk test over 2 years \\\\\n- Change from baseline in the PGA over 2 years \\\\\n- Change from baseline in minimal joint space width in the medial and lateral compartments as evaluated by X-ray over 2 years \\\\\n- Change from baseline in cartilage thickness in the medial and lateral compartments as well as in the total femorotibial joint over 2 years \\\\\n- Change from baseline in cartilage volume in the medial and lateral compartments as well as in the total femorotibial joint over 2 years \\\\\n- Synovial fluid levels of sprifermin/FGF-18 \\\\\n- Serum levels of sprifermin/FGF-18\n\\end{tabular} \\\\\n\\hline Safety endpoints & \\begin{tabular}{l}\n- Nature, incidence and severity of local and systemic AEs \\\\\n- Incidence of acute inflammatory reactions (AIRs), defined as increase of pain by 30 mm on a 100 mm visual analogue scale (VAS) and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days following i.a. injection (see Section 7.4.1.1) \\\\\n- Changes in laboratory safety parameters, vital signs, 12-lead electrocardiogram (ECG) parameters, weight, and physical examinations \\\\\n- Incidence of surgical interventions in the target knee (including any surgical revision, cartilage removal, or any other type of surgical intervention). \\\\\n- Occurrence of binding and neutralizing antibodies to sprifermin/FGF-18\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Reference therapy: dose/mode of administration/dosing schedule & Placebo to match sprifermin, administered i.a. (see treatment regimen described above for sprifermin) \\\\\n\\hline Planned treatment duration per subject & 2 years \\\\\n\\hline Primary endpoint & Change from baseline in cartilage thickness in the total femorotibial joint as evaluated by MRI at 2 years \\\\\n\\hline Secondary endpoints & \\begin{tabular}{l}\n- Changes from baseline in the WOMAC total score and in the WOMAC pain, function, and stiffness index scores over 2 years \\\\\n- Change from baseline in the 20 -meter walk test over 2 years \\\\\n- Change from baseline in the PGA over 2 years \\\\\n- Change from baseline in minimal joint space width in the medial and lateral compartments as evaluated by X-ray over 2 years \\\\\n- Change from baseline in cartilage thickness in the medial and lateral compartments as well as in the total femorotibial joint over 2 years \\\\\n- Change from baseline in cartilage volume in the medial and lateral compartments as well as in the total femorotibial joint over 2 years \\\\\n- Synovial fluid levels of sprifermin/FGF-18 \\\\\n- Serum levels of sprifermin/FGF-18\n\\end{tabular} \\\\\n\\hline Safety endpoints & \\begin{tabular}{l}\n- Nature, incidence and severity of local and systemic AEs \\\\\n- Incidence of acute inflammatory reactions (AIRs), defined as increase of pain by 30 mm on a 100 mm visual analogue scale (VAS) and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days following i.a. injection (see Section 7.4.1.1) \\\\\n- Changes in laboratory safety parameters, vital signs, 12-lead electrocardiogram (ECG) parameters, weight, and physical examinations \\\\\n- Incidence of surgical interventions in the target knee (including any surgical revision, cartilage removal, or any other type of surgical intervention). \\\\\n- Occurrence of binding and neutralizing antibodies to sprifermin/FGF-18\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.9975600242614746,"confidence_rate":0.9999991208771402},{"cnt":[[261,270],[863,270],[863,2472],[261,2472]],"region":{"top_left_x":261,"top_left_y":270,"width":603,"height":2203},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d600c45f766d4c79818a9ccd67acf0a8","type":"table_column","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"","text_display":""},{"cnt":[[879,270],[1883,270],[1883,2474],[879,2474]],"region":{"top_left_x":878,"top_left_y":270,"width":1006,"height":2205},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b67cb2c615854411b4d44ed0ede5e0c4","type":"table_column","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"","text_display":""},{"cnt":[[242,322],[1883,322],[1883,428],[242,428]],"region":{"top_left_x":242,"top_left_y":321,"width":1642,"height":108},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58ab9a2901d44e20becbc21e55e68832","type":"table_row","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"","text_display":""},{"cnt":[[242,461],[1883,461],[1883,567],[242,567]],"region":{"top_left_x":242,"top_left_y":460,"width":1642,"height":107},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c14057e2c406457ea6305d65123173be","type":"table_row","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"","text_display":""},{"cnt":[[242,599],[1883,599],[1883,705],[242,705]],"region":{"top_left_x":242,"top_left_y":599,"width":1642,"height":107},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"efa38a1c1aa040bcb53c8060f2f3b8d6","type":"table_row","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"","text_display":""},{"cnt":[[242,697],[1886,697],[1886,1665],[242,1665]],"region":{"top_left_x":242,"top_left_y":696,"width":1644,"height":969},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57d7e5926a3b49d49bbf1956e0ca102f","type":"table_row","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"","text_display":""},{"cnt":[[242,1678],[1886,1678],[1886,2468],[242,2468]],"region":{"top_left_x":242,"top_left_y":1677,"width":1644,"height":791},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"027f5b4dbee947e8bed125b89198d844","type":"table_row","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"","text_display":""},{"cnt":[[261,324],[863,324],[863,428],[261,428]],"region":{"top_left_x":261,"top_left_y":324,"width":603,"height":105},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9404124aac354bd89ef65393020814d2","type":"complex_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","children_ids":["0417345b577f4ab0b7654fcfa1270be6","1cb8553944374a629e8044a6cde54425"],"text":"Reference therapy: dose/mode of administration/dosing schedule","text_display":"Reference therapy: dose/mode of administration/dosing schedule","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,326],[861,326],[861,376],[264,376]],"region":{"top_left_x":263,"top_left_y":326,"width":599,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0417345b577f4ab0b7654fcfa1270be6","type":"text","conversion_output":false,"parent_id":"9404124aac354bd89ef65393020814d2","text":"Reference therapy: dose/mode of","text_display":"Reference therapy: dose/mode of","confidence":1,"confidence_rate":1},{"cnt":[[266,376],[827,376],[827,424],[266,424]],"region":{"top_left_x":265,"top_left_y":376,"width":562,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cb8553944374a629e8044a6cde54425","type":"text","conversion_output":false,"parent_id":"9404124aac354bd89ef65393020814d2","text":"administration/dosing schedule","text_display":" administration/dosing schedule","confidence":1,"confidence_rate":1},{"cnt":[[885,322],[1866,322],[1866,424],[885,424]],"region":{"top_left_x":885,"top_left_y":321,"width":982,"height":103},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e93ce69b6914920bcab630f8e688d38","type":"complex_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","children_ids":["eec9e858cc8a49aea020ec91dd92b83e","0e2b9c2796d0490bb92d11bbd067bfd5"],"text":"Placebo to match sprifermin, administered i.a. (see treatment regimen described above for sprifermin)","text_display":"Placebo to match sprifermin, administered i.a. (see treatment regimen described above for sprifermin)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999956392907747},{"cnt":[[887,326],[1864,326],[1864,376],[887,376]],"region":{"top_left_x":887,"top_left_y":326,"width":977,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eec9e858cc8a49aea020ec91dd92b83e","type":"text","conversion_output":false,"parent_id":"4e93ce69b6914920bcab630f8e688d38","text":"Placebo to match sprifermin, administered i.a. (see","text_display":"Placebo to match sprifermin, administered i.a. (see","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[887,374],[1734,374],[1734,422],[887,422]],"region":{"top_left_x":887,"top_left_y":373,"width":848,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e2b9c2796d0490bb92d11bbd067bfd5","type":"text","conversion_output":false,"parent_id":"4e93ce69b6914920bcab630f8e688d38","text":"treatment regimen described above for sprifermin)","text_display":" treatment regimen described above for sprifermin)","confidence":1,"confidence_rate":1},{"cnt":[[261,463],[861,463],[861,567],[261,567]],"region":{"top_left_x":261,"top_left_y":462,"width":601,"height":105},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fa844eaae0c4d798813d3197ef79c89","type":"complex_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","children_ids":["2757ced474d64104b1e24a12110360e8","92c2ded379ea410891263a36eb2d541a"],"text":"Planned treatment duration per subject","text_display":"Planned treatment duration per subject","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,465],[859,465],[859,515],[264,515]],"region":{"top_left_x":263,"top_left_y":464,"width":597,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2757ced474d64104b1e24a12110360e8","type":"text","conversion_output":false,"parent_id":"2fa844eaae0c4d798813d3197ef79c89","text":"Planned treatment duration per","text_display":"Planned treatment duration per","confidence":1,"confidence_rate":1},{"cnt":[[264,515],[400,515],[400,562],[264,562]],"region":{"top_left_x":263,"top_left_y":514,"width":138,"height":49},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92c2ded379ea410891263a36eb2d541a","type":"text","conversion_output":false,"parent_id":"2fa844eaae0c4d798813d3197ef79c89","text":"subject","text_display":" subject","confidence":1,"confidence_rate":1},{"cnt":[[887,465],[1015,465],[1015,515],[887,515]],"region":{"top_left_x":887,"top_left_y":464,"width":129,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"625cd00f20a4441ab86de7c2394a4ddd","type":"simple_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"2 years","text_display":"2 years","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,603],[593,603],[593,653],[264,653]],"region":{"top_left_x":263,"top_left_y":603,"width":330,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15a2099188584063b3ce6d6e34b32a92","type":"simple_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"Primary endpoint","text_display":"Primary endpoint","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[885,599],[1866,599],[1866,705],[885,705]],"region":{"top_left_x":885,"top_left_y":599,"width":982,"height":107},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01d5d93825fe41c2b7871e11307bafb5","type":"complex_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","children_ids":["232e6216d5a147748e5cc7fa6475205c","6b54c1c77e4d409396da9bc9d04b7153"],"text":"Change from baseline in cartilage thickness in the total femorotibial joint as evaluated by MRI at 2 years","text_display":"Change from baseline in cartilage thickness in the total femorotibial joint as evaluated by MRI at 2 years","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[887,603],[1864,603],[1864,653],[887,653]],"region":{"top_left_x":887,"top_left_y":603,"width":977,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"232e6216d5a147748e5cc7fa6475205c","type":"text","conversion_output":false,"parent_id":"01d5d93825fe41c2b7871e11307bafb5","text":"Change from baseline in cartilage thickness in the total","text_display":"Change from baseline in cartilage thickness in the total","confidence":1,"confidence_rate":1},{"cnt":[[887,651],[1717,651],[1717,701],[887,701]],"region":{"top_left_x":887,"top_left_y":651,"width":830,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b54c1c77e4d409396da9bc9d04b7153","type":"text","conversion_output":false,"parent_id":"01d5d93825fe41c2b7871e11307bafb5","text":"femorotibial joint as evaluated by MRI at 2 years","text_display":" femorotibial joint as evaluated by MRI at 2 years","confidence":1,"confidence_rate":1},{"cnt":[[264,703],[645,703],[645,753],[264,753]],"region":{"top_left_x":263,"top_left_y":703,"width":382,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"904fc41210bf488996263fa91d34819c","type":"simple_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"Secondary endpoints","text_display":"Secondary endpoints","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[885,720],[1868,720],[1868,1662],[885,1662]],"region":{"top_left_x":885,"top_left_y":720,"width":984,"height":943},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05eceadab338461ba63b538fcd54ca30","type":"complex_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","children_ids":["7b9789ce56fb4bd481583ca494e68b72","ea5bec766e684c01bf04940282cbb118","12926386a79f42d5b3316e98d651f13e","0c0c310e5cc7476e93b019c66fe7c2cc","18ec5c778af0450f8c98313b4ca74981","3366ff0d9b744f5aa72f83ff5d6769bf","295b30f6a4d54cc0a8dadbc654818457","f7048bd546cf40a09ea44227795f11aa","38d915a1d16e4caa84ad73843c5a99e7","1ef6b2c7f33d4aaab98d5b5351672d58","8a1492c9a64d44ecba163543c5ae9413","cc9c4a17ff874e7a80d5255d6dee5653","d0380266617641e0b9123a9582ba20a5","ee0dbb9d89f5487e8063ce2721f641e9","d567bfa7d8354a3e8e4f03449b3412c5","e9608c43a10640c09e0213db7759060d","13dfe79a520b41d3a0853d39a037b168"],"text":"\\begin{tabular}{l}\n- Changes from baseline in the WOMAC total score and in the WOMAC pain, function, and stiffness index scores over 2 years \\\\\n- Change from baseline in the 20 -meter walk test over 2 years \\\\\n- Change from baseline in the PGA over 2 years \\\\\n- Change from baseline in minimal joint space width in the medial and lateral compartments as evaluated by X-ray over 2 years \\\\\n- Change from baseline in cartilage thickness in the medial and lateral compartments as well as in the total femorotibial joint over 2 years \\\\\n- Change from baseline in cartilage volume in the medial and lateral compartments as well as in the total femorotibial joint over 2 years \\\\\n- Synovial fluid levels of sprifermin/FGF-18 \\\\\n- Serum levels of sprifermin/FGF-18\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n- Changes from baseline in the WOMAC total score and in the WOMAC pain, function, and stiffness index scores over 2 years \\\\\n- Change from baseline in the 20 -meter walk test over 2 years \\\\\n- Change from baseline in the PGA over 2 years \\\\\n- Change from baseline in minimal joint space width in the medial and lateral compartments as evaluated by X-ray over 2 years \\\\\n- Change from baseline in cartilage thickness in the medial and lateral compartments as well as in the total femorotibial joint over 2 years \\\\\n- Change from baseline in cartilage volume in the medial and lateral compartments as well as in the total femorotibial joint over 2 years \\\\\n- Synovial fluid levels of sprifermin/FGF-18 \\\\\n- Serum levels of sprifermin/FGF-18\n\\end{tabular}","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9975600242614746,"confidence_rate":0.9999961509228424},{"cnt":[[887,725],[1864,725],[1864,775],[887,775]],"region":{"top_left_x":887,"top_left_y":724,"width":977,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b9789ce56fb4bd481583ca494e68b72","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"- Changes from baseline in the WOMAC total score and","text_display":"- Changes from baseline in the WOMAC total score and","confidence":1,"confidence_rate":1},{"cnt":[[937,772],[1864,772],[1864,822],[937,822]],"region":{"top_left_x":937,"top_left_y":772,"width":927,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea5bec766e684c01bf04940282cbb118","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"in the WOMAC pain, function, and stiffness index","text_display":" in the WOMAC pain, function, and stiffness index","confidence":1,"confidence_rate":1},{"cnt":[[937,820],[1262,820],[1262,870],[937,870]],"region":{"top_left_x":937,"top_left_y":820,"width":325,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12926386a79f42d5b3316e98d651f13e","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"scores over 2 years","text_display":" scores over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[887,885],[1864,885],[1864,935],[887,935]],"region":{"top_left_x":887,"top_left_y":884,"width":977,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c0c310e5cc7476e93b019c66fe7c2cc","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"- Change from baseline in the 20 -meter walk test over 2","text_display":"\n- Change from baseline in the 20 -meter walk test over 2","confidence":0.9975600242614746,"confidence_rate":0.9999612236513408},{"cnt":[[935,941],[1032,941],[1032,982],[935,982]],"region":{"top_left_x":934,"top_left_y":941,"width":99,"height":42},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18ec5c778af0450f8c98313b4ca74981","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"years","text_display":" years","confidence":1,"confidence_rate":1},{"cnt":[[887,998],[1721,998],[1721,1047],[887,1047]],"region":{"top_left_x":887,"top_left_y":997,"width":835,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3366ff0d9b744f5aa72f83ff5d6769bf","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"- Change from baseline in the PGA over 2 years","text_display":"\n- Change from baseline in the PGA over 2 years","confidence":0.99951171875,"confidence_rate":0.9999909555872323},{"cnt":[[887,1063],[1864,1063],[1864,1112],[887,1112]],"region":{"top_left_x":887,"top_left_y":1062,"width":977,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"295b30f6a4d54cc0a8dadbc654818457","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"- Change from baseline in minimal joint space width in","text_display":"\n- Change from baseline in minimal joint space width in","confidence":1,"confidence_rate":1},{"cnt":[[937,1110],[1864,1110],[1864,1160],[937,1160]],"region":{"top_left_x":937,"top_left_y":1110,"width":927,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7048bd546cf40a09ea44227795f11aa","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"the medial and lateral compartments as evaluated by","text_display":" the medial and lateral compartments as evaluated by","confidence":1,"confidence_rate":1},{"cnt":[[935,1162],[1258,1162],[1258,1208],[935,1208]],"region":{"top_left_x":934,"top_left_y":1162,"width":324,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38d915a1d16e4caa84ad73843c5a99e7","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"X-ray over 2 years","text_display":" X-ray over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[887,1225],[1864,1225],[1864,1273],[887,1273]],"region":{"top_left_x":887,"top_left_y":1224,"width":977,"height":49},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ef6b2c7f33d4aaab98d5b5351672d58","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"- Change from baseline in cartilage thickness in the","text_display":"\n- Change from baseline in cartilage thickness in the","confidence":0.99951171875,"confidence_rate":0.9999914316069175},{"cnt":[[937,1270],[1864,1270],[1864,1320],[937,1320]],"region":{"top_left_x":937,"top_left_y":1270,"width":927,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a1492c9a64d44ecba163543c5ae9413","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"medial and lateral compartments as well as in the total","text_display":" medial and lateral compartments as well as in the total","confidence":1,"confidence_rate":1},{"cnt":[[937,1318],[1453,1318],[1453,1368],[937,1368]],"region":{"top_left_x":937,"top_left_y":1318,"width":516,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc9c4a17ff874e7a80d5255d6dee5653","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"femorotibial joint over 2 years","text_display":" femorotibial joint over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[887,1383],[1864,1383],[1864,1433],[887,1433]],"region":{"top_left_x":887,"top_left_y":1383,"width":977,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0380266617641e0b9123a9582ba20a5","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"- Change from baseline in cartilage volume in the","text_display":"\n- Change from baseline in cartilage volume in the","confidence":0.99951171875,"confidence_rate":0.9999909555872323},{"cnt":[[937,1433],[1864,1433],[1864,1481],[937,1481]],"region":{"top_left_x":937,"top_left_y":1432,"width":927,"height":49},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee0dbb9d89f5487e8063ce2721f641e9","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"medial and lateral compartments as well as in the total","text_display":" medial and lateral compartments as well as in the total","confidence":1,"confidence_rate":1},{"cnt":[[937,1478],[1450,1478],[1450,1528],[937,1528]],"region":{"top_left_x":937,"top_left_y":1478,"width":514,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d567bfa7d8354a3e8e4f03449b3412c5","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"femorotibial joint over 2 years","text_display":" femorotibial joint over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[887,1543],[1660,1543],[1660,1593],[887,1593]],"region":{"top_left_x":887,"top_left_y":1543,"width":774,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9608c43a10640c09e0213db7759060d","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"- Synovial fluid levels of sprifermin/FGF-18","text_display":"\n- Synovial fluid levels of sprifermin/FGF-18","confidence":1,"confidence_rate":1},{"cnt":[[887,1608],[1530,1608],[1530,1658],[887,1658]],"region":{"top_left_x":887,"top_left_y":1608,"width":644,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13dfe79a520b41d3a0853d39a037b168","type":"text","conversion_output":false,"parent_id":"05eceadab338461ba63b538fcd54ca30","text":"- Serum levels of sprifermin/FGF-18","text_display":"\n- Serum levels of sprifermin/FGF-18","confidence":1,"confidence_rate":1},{"cnt":[[264,1701],[569,1701],[569,1751],[264,1751]],"region":{"top_left_x":263,"top_left_y":1701,"width":306,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38a844260998404a8611de419254c9af","type":"simple_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","text":"Safety endpoints","text_display":"Safety endpoints","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[883,1678],[1881,1678],[1881,2468],[883,2468]],"region":{"top_left_x":882,"top_left_y":1677,"width":1000,"height":791},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"898bb35a7e5846f188ea80693217be30","type":"complex_cell","conversion_output":false,"parent_id":"6dbda5d8b40949bba4428ea7620c597f","children_ids":["1416e4ebfdbd447e8021d0e1d613597f","986a1ffa478b41bcbee5ed6fe036711e","4af9b6571d524bfeb17fecf563c1ea90","8685c23ecadf403789d9cb2b57c1b706","376763b43c56468a867758e47abe3af6","36e37808493f426c8a241227d0ba9bde","8cd755ce0eeb4c04b2b36ee895abc6b1","a913feaf3f324e0abbcae7fd54fe9b6e","cef70c1e91fb467faf86c05df3ecc974","be63b7e798974ae5b328d6e1159f37b2","e4e9bee54f4a4d6db97a7c64bb890337","cf723a859e3343aa903cd1ad7d60464c","68dbe838587941e4819be836c012ce5e","61d234ced7144753b83d49f4d7115346","bc2e00e5a51c4d7d99a38b1abb7990e9"],"text":"\\begin{tabular}{l}\n- Nature, incidence and severity of local and systemic AEs \\\\\n- Incidence of acute inflammatory reactions (AIRs), defined as increase of pain by 30 mm on a 100 mm visual analogue scale (VAS) and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days following i.a. injection (see Section 7.4.1.1) \\\\\n- Changes in laboratory safety parameters, vital signs, 12-lead electrocardiogram (ECG) parameters, weight, and physical examinations \\\\\n- Incidence of surgical interventions in the target knee (including any surgical revision, cartilage removal, or any other type of surgical intervention). \\\\\n- Occurrence of binding and neutralizing antibodies to sprifermin/FGF-18\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n- Nature, incidence and severity of local and systemic AEs \\\\\n- Incidence of acute inflammatory reactions (AIRs), defined as increase of pain by 30 mm on a 100 mm visual analogue scale (VAS) and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days following i.a. injection (see Section 7.4.1.1) \\\\\n- Changes in laboratory safety parameters, vital signs, 12-lead electrocardiogram (ECG) parameters, weight, and physical examinations \\\\\n- Incidence of surgical interventions in the target knee (including any surgical revision, cartilage removal, or any other type of surgical intervention). \\\\\n- Occurrence of binding and neutralizing antibodies to sprifermin/FGF-18\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999994185710046},{"cnt":[[887,1682],[1864,1682],[1864,1732],[887,1732]],"region":{"top_left_x":887,"top_left_y":1681,"width":977,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1416e4ebfdbd447e8021d0e1d613597f","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"- Nature, incidence and severity of local and systemic","text_display":"- Nature, incidence and severity of local and systemic","confidence":1,"confidence_rate":1},{"cnt":[[937,1734],[1017,1734],[1017,1773],[937,1773]],"region":{"top_left_x":937,"top_left_y":1733,"width":81,"height":40},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"986a1ffa478b41bcbee5ed6fe036711e","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"AEs","text_display":" AEs","confidence":1,"confidence_rate":1},{"cnt":[[887,1797],[1864,1797],[1864,1844],[887,1844]],"region":{"top_left_x":887,"top_left_y":1796,"width":977,"height":49},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4af9b6571d524bfeb17fecf563c1ea90","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"- Incidence of acute inflammatory reactions (AIRs),","text_display":"\n- Incidence of acute inflammatory reactions (AIRs),","confidence":1,"confidence_rate":1},{"cnt":[[937,1842],[1864,1842],[1864,1892],[937,1892]],"region":{"top_left_x":937,"top_left_y":1842,"width":927,"height":50},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8685c23ecadf403789d9cb2b57c1b706","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"defined as increase of pain by 30 mm on a 100 mm","text_display":" defined as increase of pain by 30 mm on a 100 mm","confidence":1,"confidence_rate":1},{"cnt":[[937,1890],[1864,1890],[1864,1940],[937,1940]],"region":{"top_left_x":937,"top_left_y":1889,"width":927,"height":51},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"376763b43c56468a867758e47abe3af6","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"visual analogue scale (VAS) and a self-reported","text_display":" visual analogue scale (VAS) and a self-reported","confidence":1,"confidence_rate":1},{"cnt":[[937,1937],[1862,1937],[1862,1987],[937,1987]],"region":{"top_left_x":937,"top_left_y":1937,"width":925,"height":51},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36e37808493f426c8a241227d0ba9bde","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"synovial fluid effusion (i.e., joint swelling) within 3","text_display":" synovial fluid effusion (i.e., joint swelling) within 3","confidence":1,"confidence_rate":1},{"cnt":[[937,1987],[1762,1987],[1762,2039],[937,2039]],"region":{"top_left_x":937,"top_left_y":1987,"width":826,"height":53},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cd755ce0eeb4c04b2b36ee895abc6b1","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"days following i.a. injection (see Section 7.4.1.1)","text_display":" days following i.a. injection (see Section 7.4.1.1)","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[887,2050],[1864,2050],[1864,2102],[887,2102]],"region":{"top_left_x":887,"top_left_y":2050,"width":977,"height":53},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a913feaf3f324e0abbcae7fd54fe9b6e","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"- Changes in laboratory safety parameters, vital signs,","text_display":"\n- Changes in laboratory safety parameters, vital signs,","confidence":1,"confidence_rate":1},{"cnt":[[939,2098],[1864,2098],[1864,2150],[939,2150]],"region":{"top_left_x":939,"top_left_y":2097,"width":925,"height":53},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cef70c1e91fb467faf86c05df3ecc974","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"12-lead electrocardiogram (ECG) parameters, weight,","text_display":" 12-lead electrocardiogram (ECG) parameters, weight,","confidence":1,"confidence_rate":1},{"cnt":[[937,2150],[1388,2150],[1388,2199],[937,2199]],"region":{"top_left_x":937,"top_left_y":2149,"width":451,"height":51},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be63b7e798974ae5b328d6e1159f37b2","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"and physical examinations","text_display":" and physical examinations","confidence":1,"confidence_rate":1},{"cnt":[[887,2212],[1864,2212],[1864,2264],[887,2264]],"region":{"top_left_x":887,"top_left_y":2212,"width":977,"height":53},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4e9bee54f4a4d6db97a7c64bb890337","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"- Incidence of surgical interventions in the target knee","text_display":"\n- Incidence of surgical interventions in the target knee","confidence":1,"confidence_rate":1},{"cnt":[[937,2258],[1864,2258],[1864,2310],[937,2310]],"region":{"top_left_x":937,"top_left_y":2257,"width":927,"height":53},"line":58,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf723a859e3343aa903cd1ad7d60464c","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"(including any surgical revision, cartilage removal, or","text_display":" (including any surgical revision, cartilage removal, or","confidence":1,"confidence_rate":1},{"cnt":[[937,2308],[1604,2308],[1604,2358],[937,2358]],"region":{"top_left_x":937,"top_left_y":2307,"width":668,"height":51},"line":59,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68dbe838587941e4819be836c012ce5e","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"any other type of surgical intervention).","text_display":" any other type of surgical intervention).","confidence":1,"confidence_rate":1},{"cnt":[[887,2422],[887,2370],[1864,2373],[1864,2425]],"region":{"top_left_x":887,"top_left_y":2370,"width":978,"height":55},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61d234ced7144753b83d49f4d7115346","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"- Occurrence of binding and neutralizing antibodies to","text_display":"\n- Occurrence of binding and neutralizing antibodies to","confidence":1,"confidence_rate":1},{"cnt":[[937,2420],[1262,2420],[1262,2468],[937,2468]],"region":{"top_left_x":937,"top_left_y":2420,"width":325,"height":48},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc2e00e5a51c4d7d99a38b1abb7990e9","type":"text","conversion_output":false,"parent_id":"898bb35a7e5846f188ea80693217be30","text":"sprifermin/FGF-18","text_display":" sprifermin/FGF-18","confidence":1,"confidence_rate":1},{"cnt":[[245,2505],[440,2505],[440,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2505,"width":197,"height":41},"line":62,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4c884d0952754333a9133848b6edeea9","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[389,2544],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":145,"height":46},"line":63,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3be2bd36ec424c708c9644e79f0ef394","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1504,2522],[1603,2522],[1603,2563],[1504,2563]],"region":{"top_left_x":1503,"top_left_y":2522,"width":100,"height":42},"line":64,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"dfc68dd50f67468f915ad5b7bd4721b3","type":"page_info","conversion_output":false,"text":"22/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-023","page":23,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9263ee976a3d41d488daa191c4962ba1","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5652aace87f04ca8bfb3d51f54e201e0","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c24ae13ec934990abd96e9346d5db04","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,271],[1886,271],[1886,2396],[243,2396]],"region":{"top_left_x":242,"top_left_y":270,"width":1645,"height":2126},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"382c6b2ccd48483192636e3e5d81dcd3","type":"table","conversion_output":true,"children_ids":["4fadf0cc88344e02abcc1f3f3fc99b0f","d19e11eb16a34569aa887333b93aa173","17d3b0407cec41418c0902fa31b92ca0","357c2bb20c8b4c7ab50c1a392826758a","675a015fe38943f7801d367526e34a95"],"text":"\\begin{tabular}{|l|l|}\n\\hline Exploratory endpoints & \\begin{tabular}{l}\n- Outcome Measures in Rheumatology - Osteoarthritis Research Society International (OMERACT-OARSI) responder rate (1) at 2 years \\\\\n- PGIC over 2 years \\\\\n- Changes from baseline in the scores of the KOOS QOL and the MOS SF-36 questionnaire over 2 years \\\\\n- Change from baseline in KOOS Symptom Index over 2 years \\\\\n- Change from baseline in NRS pain score in the target and contralateral knee over 2 years using an 11-point NRS \\\\\n- Change from baseline in presence of pain in other joints over 2 years \\\\\n- Change from baseline in ICOAP scores over 2 years \\\\\n- Change over time in structural as well as compositional parameters of the knee joint (e.g., synovium, menisci, bone, and other structures) as evaluated by MRI \\\\\n- Change from baseline in serum, urine, and synovial markers associated with administration of the compound \\\\\n- Baseline protein markers and/or genetic markers associated with response to treatment or disease progression (response assessed by MRI and/or questionnaire) \\\\\n- Changes in MRI outcomes, WOMAC scores, 20-meter walk test, PGA, PGIC, JSW, OMERACT-OARSI responder rate, KOOS QOL, KOOS Symptom Index, MOS SF-36, NRS pain score in the target and contralateral knee, presence of pain in other joints, ICOAP, safety laboratory values, and vital signs over the extended follow-up period and nature, incidence and severity of local and systemic AEs during the extended follow-up period (to be summarized descriptively) \\\\\n- Relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a function of time\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Exploratory endpoints & \\begin{tabular}{l}\n- Outcome Measures in Rheumatology - Osteoarthritis Research Society International (OMERACT-OARSI) responder rate (1) at 2 years \\\\\n- PGIC over 2 years \\\\\n- Changes from baseline in the scores of the KOOS QOL and the MOS SF-36 questionnaire over 2 years \\\\\n- Change from baseline in KOOS Symptom Index over 2 years \\\\\n- Change from baseline in NRS pain score in the target and contralateral knee over 2 years using an 11-point NRS \\\\\n- Change from baseline in presence of pain in other joints over 2 years \\\\\n- Change from baseline in ICOAP scores over 2 years \\\\\n- Change over time in structural as well as compositional parameters of the knee joint (e.g., synovium, menisci, bone, and other structures) as evaluated by MRI \\\\\n- Change from baseline in serum, urine, and synovial markers associated with administration of the compound \\\\\n- Baseline protein markers and/or genetic markers associated with response to treatment or disease progression (response assessed by MRI and/or questionnaire) \\\\\n- Changes in MRI outcomes, WOMAC scores, 20-meter walk test, PGA, PGIC, JSW, OMERACT-OARSI responder rate, KOOS QOL, KOOS Symptom Index, MOS SF-36, NRS pain score in the target and contralateral knee, presence of pain in other joints, ICOAP, safety laboratory values, and vital signs over the extended follow-up period and nature, incidence and severity of local and systemic AEs during the extended follow-up period (to be summarized descriptively) \\\\\n- Relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a function of time\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.994140625,"confidence_rate":0.99999670779479},{"cnt":[[253,270],[687,270],[687,2393],[253,2393]],"region":{"top_left_x":252,"top_left_y":270,"width":435,"height":2123},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4fadf0cc88344e02abcc1f3f3fc99b0f","type":"table_column","conversion_output":false,"parent_id":"382c6b2ccd48483192636e3e5d81dcd3","text":"","text_display":""},{"cnt":[[870,273],[1884,273],[1884,2393],[870,2393]],"region":{"top_left_x":869,"top_left_y":272,"width":1016,"height":2121},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d19e11eb16a34569aa887333b93aa173","type":"table_column","conversion_output":false,"parent_id":"382c6b2ccd48483192636e3e5d81dcd3","text":"","text_display":""},{"cnt":[[242,273],[1887,273],[1887,2393],[242,2393]],"region":{"top_left_x":242,"top_left_y":272,"width":1646,"height":2121},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17d3b0407cec41418c0902fa31b92ca0","type":"table_row","conversion_output":false,"parent_id":"382c6b2ccd48483192636e3e5d81dcd3","text":"","text_display":""},{"cnt":[[264,325],[676,325],[676,376],[264,376]],"region":{"top_left_x":263,"top_left_y":324,"width":413,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"357c2bb20c8b4c7ab50c1a392826758a","type":"simple_cell","conversion_output":false,"parent_id":"382c6b2ccd48483192636e3e5d81dcd3","text":"Exploratory endpoints","text_display":"Exploratory endpoints","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[880,300],[1874,300],[1874,2384],[880,2384]],"region":{"top_left_x":880,"top_left_y":300,"width":994,"height":2085},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"675a015fe38943f7801d367526e34a95","type":"complex_cell","conversion_output":false,"parent_id":"382c6b2ccd48483192636e3e5d81dcd3","children_ids":["8159e93346ca4bafa76ab2c246a0901a","e1a39d6805a848ff9296c56967057cd6","ea8a18422ca248e2a0f2aceaae569ede","172a1e2fc1ee4ba3a916dd59d5a81ddf","f0232e14083643ccb16d00b6756803f1","903e14b5af1b4b619a3526d0d527e82e","d7b707728eb44f6dad694e3dd78b3083","a350982e342a434d9e976d7d56f4ed4d","f869a4dffb754680b7e3b499543493bd","c88bf4a0d68a4dbe8a79b9a98fe65fca","19329709fafa41f794b81f67a978d18d","066181369611447394c53b652a24f62d","33f74be450df42059731da92f692b7a5","bbd5a9e83ce845e6a5ab0769ac374e84","59f7c4363e794037bd2a7ef93bbeaa6c","79289380a6de462cba508bc6a79663dc","9f35fc0627f743ce8f5a1e3598c85a64","987a36f765dd470784fb72748d5967a1","ca5ea9eda6ea4c3ba55b1a24d5dbaa3c","ed448a5e435d4d8a9ce29da3a9a2101b","bc3bf0b95937446ab59c7a964b3506ec","c4a85c42fbe344c0a002f8ab0e8f0bf5","ffa0167f39a0478fa049e4abad9c2538","e56d615dc9904718b09958e28ec70380","d0a2becc0bcc493a976f9cc55deeeb9e","fd9896f8311d485bad09377072742c2c","424c47118c7c4133bf77c3098f6bfc9a","48d56f13afae4ff2a398fdf73bfc9b8e","71b35ae1dd9f41f49817cf2c9c4b5414","68431dfcc1254e0e97de2df31dba1d48","eb7d07a8baf047c5ae2e858f9a8c225a","8a5f769b05f640a9a4330be53450a39a","deee10456170442bb501280385a7df78","1c857931adde4b8b8579757ad855a78c","e731c3566a994ebb8c4d729df17cb87c","7e73ac7d569c4667b69435c456636d7a","78eae8e819cf426fa826ecd823228922","351a9efdcf1b40e390942b8797039665"],"text":"\\begin{tabular}{l}\n- Outcome Measures in Rheumatology - Osteoarthritis Research Society International (OMERACT-OARSI) responder rate (1) at 2 years \\\\\n- PGIC over 2 years \\\\\n- Changes from baseline in the scores of the KOOS QOL and the MOS SF-36 questionnaire over 2 years \\\\\n- Change from baseline in KOOS Symptom Index over 2 years \\\\\n- Change from baseline in NRS pain score in the target and contralateral knee over 2 years using an 11-point NRS \\\\\n- Change from baseline in presence of pain in other joints over 2 years \\\\\n- Change from baseline in ICOAP scores over 2 years \\\\\n- Change over time in structural as well as compositional parameters of the knee joint (e.g., synovium, menisci, bone, and other structures) as evaluated by MRI \\\\\n- Change from baseline in serum, urine, and synovial markers associated with administration of the compound \\\\\n- Baseline protein markers and/or genetic markers associated with response to treatment or disease progression (response assessed by MRI and/or questionnaire) \\\\\n- Changes in MRI outcomes, WOMAC scores, 20-meter walk test, PGA, PGIC, JSW, OMERACT-OARSI responder rate, KOOS QOL, KOOS Symptom Index, MOS SF-36, NRS pain score in the target and contralateral knee, presence of pain in other joints, ICOAP, safety laboratory values, and vital signs over the extended follow-up period and nature, incidence and severity of local and systemic AEs during the extended follow-up period (to be summarized descriptively) \\\\\n- Relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a function of time\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n- Outcome Measures in Rheumatology - Osteoarthritis Research Society International (OMERACT-OARSI) responder rate (1) at 2 years \\\\\n- PGIC over 2 years \\\\\n- Changes from baseline in the scores of the KOOS QOL and the MOS SF-36 questionnaire over 2 years \\\\\n- Change from baseline in KOOS Symptom Index over 2 years \\\\\n- Change from baseline in NRS pain score in the target and contralateral knee over 2 years using an 11-point NRS \\\\\n- Change from baseline in presence of pain in other joints over 2 years \\\\\n- Change from baseline in ICOAP scores over 2 years \\\\\n- Change over time in structural as well as compositional parameters of the knee joint (e.g., synovium, menisci, bone, and other structures) as evaluated by MRI \\\\\n- Change from baseline in serum, urine, and synovial markers associated with administration of the compound \\\\\n- Baseline protein markers and/or genetic markers associated with response to treatment or disease progression (response assessed by MRI and/or questionnaire) \\\\\n- Changes in MRI outcomes, WOMAC scores, 20-meter walk test, PGA, PGIC, JSW, OMERACT-OARSI responder rate, KOOS QOL, KOOS Symptom Index, MOS SF-36, NRS pain score in the target and contralateral knee, presence of pain in other joints, ICOAP, safety laboratory values, and vital signs over the extended follow-up period and nature, incidence and severity of local and systemic AEs during the extended follow-up period (to be summarized descriptively) \\\\\n- Relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a function of time\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.994140625,"confidence_rate":0.9999934156004187},{"cnt":[[886,308],[1860,308],[1860,355],[886,355]],"region":{"top_left_x":885,"top_left_y":308,"width":975,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8159e93346ca4bafa76ab2c246a0901a","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Outcome Measures in Rheumatology - Osteoarthritis","text_display":"- Outcome Measures in Rheumatology - Osteoarthritis","confidence":1,"confidence_rate":1},{"cnt":[[935,355],[1860,355],[1860,404],[935,404]],"region":{"top_left_x":934,"top_left_y":354,"width":926,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1a39d6805a848ff9296c56967057cd6","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"Research Society International (OMERACT-OARSI)","text_display":" Research Society International (OMERACT-OARSI)","confidence":1,"confidence_rate":1},{"cnt":[[935,404],[1410,404],[1410,453],[935,453]],"region":{"top_left_x":934,"top_left_y":403,"width":476,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea8a18422ca248e2a0f2aceaae569ede","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"responder rate (1) at 2 years","text_display":" responder rate (1) at 2 years","confidence":0.9990234375,"confidence_rate":0.9999735938716796},{"cnt":[[889,477],[1254,477],[1254,524],[889,524]],"region":{"top_left_x":888,"top_left_y":477,"width":367,"height":47},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"172a1e2fc1ee4ba3a916dd59d5a81ddf","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- PGIC over 2 years","text_display":"\n- PGIC over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[889,548],[1860,548],[1860,595],[889,595]],"region":{"top_left_x":888,"top_left_y":548,"width":972,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0232e14083643ccb16d00b6756803f1","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Changes from baseline in the scores of the KOOS","text_display":"\n- Changes from baseline in the scores of the KOOS","confidence":1,"confidence_rate":1},{"cnt":[[935,592],[1822,592],[1822,644],[935,644]],"region":{"top_left_x":934,"top_left_y":591,"width":888,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"903e14b5af1b4b619a3526d0d527e82e","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"QOL and the MOS SF-36 questionnaire over 2 years","text_display":" QOL and the MOS SF-36 questionnaire over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[889,666],[1865,666],[1865,715],[889,715]],"region":{"top_left_x":888,"top_left_y":665,"width":978,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7b707728eb44f6dad694e3dd78b3083","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Change from baseline in KOOS Symptom Index over","text_display":"\n- Change from baseline in KOOS Symptom Index over","confidence":1,"confidence_rate":1},{"cnt":[[935,717],[1063,717],[1063,764],[935,764]],"region":{"top_left_x":934,"top_left_y":717,"width":130,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a350982e342a434d9e976d7d56f4ed4d","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"2 years","text_display":" 2 years","confidence":1,"confidence_rate":1},{"cnt":[[889,788],[1865,788],[1865,835],[889,835]],"region":{"top_left_x":888,"top_left_y":788,"width":978,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f869a4dffb754680b7e3b499543493bd","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Change from baseline in NRS pain score in the target","text_display":"\n- Change from baseline in NRS pain score in the target","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[935,832],[1865,832],[1865,884],[935,884]],"region":{"top_left_x":934,"top_left_y":832,"width":932,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c88bf4a0d68a4dbe8a79b9a98fe65fca","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"and contralateral knee over 2 years using an 11-point","text_display":" and contralateral knee over 2 years using an 11-point","confidence":0.998046875,"confidence_rate":0.9999679507621811},{"cnt":[[935,881],[1028,881],[1028,925],[935,925]],"region":{"top_left_x":934,"top_left_y":881,"width":94,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19329709fafa41f794b81f67a978d18d","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"NRS","text_display":" NRS","confidence":1,"confidence_rate":1},{"cnt":[[889,952],[1865,952],[1865,1004],[889,1004]],"region":{"top_left_x":888,"top_left_y":952,"width":978,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"066181369611447394c53b652a24f62d","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Change from baseline in presence of pain in other","text_display":"\n- Change from baseline in presence of pain in other","confidence":1,"confidence_rate":1},{"cnt":[[935,1001],[1249,1001],[1249,1050],[935,1050]],"region":{"top_left_x":934,"top_left_y":1001,"width":315,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33f74be450df42059731da92f692b7a5","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"joints over 2 years","text_display":" joints over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[886,1072],[1816,1072],[1816,1124],[886,1124]],"region":{"top_left_x":885,"top_left_y":1072,"width":932,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbd5a9e83ce845e6a5ab0769ac374e84","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Change from baseline in ICOAP scores over 2 years","text_display":"\n- Change from baseline in ICOAP scores over 2 years","confidence":0.99560546875,"confidence_rate":0.9999253550642931},{"cnt":[[889,1146],[1863,1146],[1863,1195],[889,1195]],"region":{"top_left_x":888,"top_left_y":1145,"width":975,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59f7c4363e794037bd2a7ef93bbeaa6c","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Change over time in structural as well as","text_display":"\n- Change over time in structural as well as","confidence":1,"confidence_rate":1},{"cnt":[[935,1192],[1863,1192],[1863,1241],[935,1241]],"region":{"top_left_x":934,"top_left_y":1192,"width":929,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79289380a6de462cba508bc6a79663dc","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"compositional parameters of the knee joint (e.g.,","text_display":" compositional parameters of the knee joint (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[935,1241],[1865,1241],[1865,1288],[935,1288]],"region":{"top_left_x":934,"top_left_y":1241,"width":932,"height":47},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f35fc0627f743ce8f5a1e3598c85a64","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"synovium, menisci, bone, and other structures) as","text_display":" synovium, menisci, bone, and other structures) as","confidence":1,"confidence_rate":1},{"cnt":[[935,1290],[1249,1290],[1249,1337],[935,1337]],"region":{"top_left_x":934,"top_left_y":1290,"width":315,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"987a36f765dd470784fb72748d5967a1","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"evaluated by MRI","text_display":" evaluated by MRI","confidence":1,"confidence_rate":1},{"cnt":[[886,1361],[1863,1361],[1863,1408],[886,1408]],"region":{"top_left_x":885,"top_left_y":1361,"width":978,"height":47},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca5ea9eda6ea4c3ba55b1a24d5dbaa3c","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Change from baseline in serum, urine, and synovial","text_display":"\n- Change from baseline in serum, urine, and synovial","confidence":1,"confidence_rate":1},{"cnt":[[935,1410],[1865,1410],[1865,1451],[935,1451]],"region":{"top_left_x":934,"top_left_y":1410,"width":932,"height":42},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed448a5e435d4d8a9ce29da3a9a2101b","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"markers associated with administration of the","text_display":" markers associated with administration of the","confidence":1,"confidence_rate":1},{"cnt":[[935,1460],[1123,1460],[1123,1506],[935,1506]],"region":{"top_left_x":934,"top_left_y":1459,"width":190,"height":47},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc3bf0b95937446ab59c7a964b3506ec","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"compound","text_display":" compound","confidence":1,"confidence_rate":1},{"cnt":[[886,1530],[1865,1530],[1865,1577],[886,1577]],"region":{"top_left_x":885,"top_left_y":1530,"width":981,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4a85c42fbe344c0a002f8ab0e8f0bf5","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Baseline protein markers and/or genetic markers","text_display":"\n- Baseline protein markers and/or genetic markers","confidence":1,"confidence_rate":1},{"cnt":[[935,1574],[1865,1574],[1865,1626],[935,1626]],"region":{"top_left_x":934,"top_left_y":1574,"width":932,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffa0167f39a0478fa049e4abad9c2538","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"associated with response to treatment or disease","text_display":" associated with response to treatment or disease","confidence":1,"confidence_rate":1},{"cnt":[[935,1623],[1865,1623],[1865,1672],[935,1672]],"region":{"top_left_x":934,"top_left_y":1623,"width":932,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e56d615dc9904718b09958e28ec70380","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"progression (response assessed by MRI and/or","text_display":" progression (response assessed by MRI and/or","confidence":1,"confidence_rate":1},{"cnt":[[935,1672],[1183,1672],[1183,1719],[935,1719]],"region":{"top_left_x":934,"top_left_y":1672,"width":250,"height":47},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0a2becc0bcc493a976f9cc55deeeb9e","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"questionnaire)","text_display":" questionnaire)","confidence":1,"confidence_rate":1},{"cnt":[[889,1743],[1865,1743],[1865,1790],[889,1790]],"region":{"top_left_x":888,"top_left_y":1743,"width":978,"height":47},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd9896f8311d485bad09377072742c2c","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Changes in MRI outcomes, WOMAC scores, 20-meter","text_display":"\n- Changes in MRI outcomes, WOMAC scores, 20-meter","confidence":0.994140625,"confidence_rate":0.9998911798382141},{"cnt":[[935,1792],[1865,1792],[1865,1839],[935,1839]],"region":{"top_left_x":934,"top_left_y":1792,"width":932,"height":47},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"424c47118c7c4133bf77c3098f6bfc9a","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"walk test, PGA, PGIC, JSW, OMERACT-OARSI","text_display":" walk test, PGA, PGIC, JSW, OMERACT-OARSI","confidence":1,"confidence_rate":1},{"cnt":[[935,1839],[1865,1839],[1865,1888],[935,1888]],"region":{"top_left_x":934,"top_left_y":1838,"width":932,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48d56f13afae4ff2a398fdf73bfc9b8e","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"responder rate, KOOS QOL, KOOS Symptom Index,","text_display":" responder rate, KOOS QOL, KOOS Symptom Index,","confidence":1,"confidence_rate":1},{"cnt":[[935,1888],[1865,1888],[1865,1937],[935,1937]],"region":{"top_left_x":934,"top_left_y":1887,"width":932,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71b35ae1dd9f41f49817cf2c9c4b5414","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"MOS SF-36, NRS pain score in the target and","text_display":" MOS SF-36, NRS pain score in the target and","confidence":1,"confidence_rate":1},{"cnt":[[935,1934],[1865,1934],[1865,1983],[935,1983]],"region":{"top_left_x":934,"top_left_y":1934,"width":932,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68431dfcc1254e0e97de2df31dba1d48","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"contralateral knee, presence of pain in other joints,","text_display":" contralateral knee, presence of pain in other joints,","confidence":1,"confidence_rate":1},{"cnt":[[935,1983],[1865,1983],[1865,2030],[935,2030]],"region":{"top_left_x":934,"top_left_y":1983,"width":932,"height":47},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb7d07a8baf047c5ae2e858f9a8c225a","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"ICOAP, safety laboratory values, and vital signs over","text_display":" ICOAP, safety laboratory values, and vital signs over","confidence":1,"confidence_rate":1},{"cnt":[[935,2030],[1865,2030],[1865,2079],[935,2079]],"region":{"top_left_x":934,"top_left_y":2029,"width":932,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a5f769b05f640a9a4330be53450a39a","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"the extended follow-up period and nature, incidence","text_display":" the extended follow-up period and nature, incidence","confidence":1,"confidence_rate":1},{"cnt":[[935,2076],[1865,2076],[1865,2128],[935,2128]],"region":{"top_left_x":934,"top_left_y":2076,"width":932,"height":53},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"deee10456170442bb501280385a7df78","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"and severity of local and systemic AEs during the","text_display":" and severity of local and systemic AEs during the","confidence":1,"confidence_rate":1},{"cnt":[[935,2125],[1865,2125],[1865,2177],[935,2177]],"region":{"top_left_x":934,"top_left_y":2125,"width":932,"height":53},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c857931adde4b8b8579757ad855a78c","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"extended follow-up period (to be summarized","text_display":" extended follow-up period (to be summarized","confidence":1,"confidence_rate":1},{"cnt":[[935,2174],[1172,2174],[1172,2223],[935,2223]],"region":{"top_left_x":934,"top_left_y":2174,"width":239,"height":50},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e731c3566a994ebb8c4d729df17cb87c","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"descriptively)","text_display":" descriptively)","confidence":1,"confidence_rate":1},{"cnt":[[886,2245],[1865,2245],[1865,2297],[886,2297]],"region":{"top_left_x":885,"top_left_y":2245,"width":981,"height":53},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e73ac7d569c4667b69435c456636d7a","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"- Relationship between dosing (dose and regimen),","text_display":"\n- Relationship between dosing (dose and regimen),","confidence":1,"confidence_rate":1},{"cnt":[[935,2294],[1871,2294],[1871,2344],[935,2344]],"region":{"top_left_x":934,"top_left_y":2294,"width":937,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78eae8e819cf426fa826ecd823228922","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"cartilage structure, and clinical scores as a function of","text_display":" cartilage structure, and clinical scores as a function of","confidence":1,"confidence_rate":1},{"cnt":[[935,2344],[1022,2344],[1022,2387],[935,2387]],"region":{"top_left_x":934,"top_left_y":2343,"width":89,"height":45},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"351a9efdcf1b40e390942b8797039665","type":"text","conversion_output":false,"parent_id":"675a015fe38943f7801d367526e34a95","text":"time","text_display":" time","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":48,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"da1324666be74b4fbc15861f24e26f7a","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2545],[389,2542],[390,2587],[245,2589]],"region":{"top_left_x":244,"top_left_y":2542,"width":146,"height":48},"line":49,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"300a4e4da3394e179ccb5562eda149fe","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1504,2527],[1601,2527],[1601,2563],[1504,2563]],"region":{"top_left_x":1503,"top_left_y":2526,"width":98,"height":38},"line":50,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5840cfe5267c4c6db3f380039efe2ecf","type":"page_info","conversion_output":false,"text":"23/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1792,2501],[1904,2501],[1904,2610],[1792,2610]],"region":{"top_left_x":1791,"top_left_y":2500,"width":113,"height":111},"line":51,"column":0,"font_size":88,"is_printed":true,"is_handwritten":false,"id":"c7dea77a2fc544cab8dd3a4899919300","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.986328125,"confidence_rate":0.9977082640850757}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-024","page":24,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0294afc6614b42f0a02dab3f6e2047ed","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68f11e11879b4f8a977d320b258dd852","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5be16ada0a4d4a6b95365a1dcd7ab932","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,271],[1895,271],[1895,2494],[241,2494]],"region":{"top_left_x":240,"top_left_y":270,"width":1655,"height":2225},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20ea0cafc93d43e190a2d2b92a160390","type":"table","conversion_output":true,"children_ids":["80773c3f167f4287b3140b3eb223cbd2","efb687b051104ccebb515680fcb0a91a","210040ed45e04117a797b31c03407ffc","ee00b68158d24d5490c1ce2ba9fdb8e2","7de617fe3043451897923c4b970d631d","8adeb1e69a6b4a18b4b650eef7f40b64","7fb906b33e7a42409fc25a26228703fd","ada1df0865594de0ba8c5c0444baf9a9","5448a639c9324156ad51724b4a7ae0d4","0a77b4487a254b6dbd9b57f8a8dfef3b","c4341899c5dd44e6b184b33337348aa4"],"text":"\\begin{tabular}{|l|l|}\n\\hline Pharmacokinetics & Levels of sprifermin/FGF-18 will be measured in serum and synovial fluid for pharmacokinetic (PK) assessment \\\\\n\\hline Other assessments & \\begin{tabular}{l}\nSubject diary information about maximum levels of target knee pain and presence or absence of target knee swelling will be used to identify potential acute inflammatory reactions to the IMP. \\\\\nExploratory pharmacogenetic (PGt) analyses will be performed for subjects who provide separate informed consent.\n\\end{tabular} \\\\\n\\hline Statistical methods (includes sample size calculation) & \\begin{tabular}{l}\nSample Size Calculation \\\\\nThe number of 545 randomized subjects has been calculated to provide \\(90 \\%\\) power to detect a dose relationship as well as an overall treatment effect in the change from baseline in cartilage thickness in the total femorotibial joint at 2 years, assuming a discontinuation rate of \\(30 \\%\\) at that time. The study is also adequately powered to detect significant difference in at least one active treatment group and the placebo group for a secondary WOMAC endpoint such as the pain, function or total WOMAC score. \\\\\nStatistical Methodology \\\\\nThe treatment effect on the primary endpoint will be assessed through dose-ranging using a repeated measurement analysis of variance (ANOVA, using PROC MIXED in SAS) on absolute change from baseline, including the baseline value, the treatment group, the time, and the country as factors and treatment by time as interaction. \\\\\nThe primary efficacy analysis will consist of testing the linear dose relationship and the overall treatment effect at 2 years. The significance level will be set at \\(5 \\%\\) twosided for both tests. \\\\\nPairwise comparisons (sprifermin versus placebo, and between sprifermin dose and regimen groups) will be performed within the context of this modeling framework. For each pairwise comparison, the difference between treatments and the corresponding 95\\% confidence interval (CI) and p -value will be presented.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Pharmacokinetics & Levels of sprifermin/FGF-18 will be measured in serum and synovial fluid for pharmacokinetic (PK) assessment \\\\\n\\hline Other assessments & \\begin{tabular}{l}\nSubject diary information about maximum levels of target knee pain and presence or absence of target knee swelling will be used to identify potential acute inflammatory reactions to the IMP. \\\\\nExploratory pharmacogenetic (PGt) analyses will be performed for subjects who provide separate informed consent.\n\\end{tabular} \\\\\n\\hline Statistical methods (includes sample size calculation) & \\begin{tabular}{l}\nSample Size Calculation \\\\\nThe number of 545 randomized subjects has been calculated to provide \\(90 \\%\\) power to detect a dose relationship as well as an overall treatment effect in the change from baseline in cartilage thickness in the total femorotibial joint at 2 years, assuming a discontinuation rate of \\(30 \\%\\) at that time. The study is also adequately powered to detect significant difference in at least one active treatment group and the placebo group for a secondary WOMAC endpoint such as the pain, function or total WOMAC score. \\\\\nStatistical Methodology \\\\\nThe treatment effect on the primary endpoint will be assessed through dose-ranging using a repeated measurement analysis of variance (ANOVA, using PROC MIXED in SAS) on absolute change from baseline, including the baseline value, the treatment group, the time, and the country as factors and treatment by time as interaction. \\\\\nThe primary efficacy analysis will consist of testing the linear dose relationship and the overall treatment effect at 2 years. The significance level will be set at \\(5 \\%\\) twosided for both tests. \\\\\nPairwise comparisons (sprifermin versus placebo, and between sprifermin dose and regimen groups) will be performed within the context of this modeling framework. For each pairwise comparison, the difference between treatments and the corresponding 95\\% confidence interval (CI) and p -value will be presented.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.5390625,"confidence_rate":0.9998810998894638},{"cnt":[[259,270],[786,270],[786,2492],[259,2492]],"region":{"top_left_x":259,"top_left_y":270,"width":527,"height":2222},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80773c3f167f4287b3140b3eb223cbd2","type":"table_column","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","text":"","text_display":""},{"cnt":[[874,270],[1881,270],[1881,2492],[874,2492]],"region":{"top_left_x":874,"top_left_y":270,"width":1008,"height":2222},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"efb687b051104ccebb515680fcb0a91a","type":"table_column","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","text":"","text_display":""},{"cnt":[[240,322],[1890,322],[1890,424],[240,424]],"region":{"top_left_x":240,"top_left_y":321,"width":1651,"height":103},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"210040ed45e04117a797b31c03407ffc","type":"table_row","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","text":"","text_display":""},{"cnt":[[240,461],[1890,461],[1890,837],[240,837]],"region":{"top_left_x":240,"top_left_y":460,"width":1651,"height":378},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee00b68158d24d5490c1ce2ba9fdb8e2","type":"table_row","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","text":"","text_display":""},{"cnt":[[240,876],[1892,876],[1892,2490],[240,2490]],"region":{"top_left_x":240,"top_left_y":876,"width":1653,"height":1614},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7de617fe3043451897923c4b970d631d","type":"table_row","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","text":"","text_display":""},{"cnt":[[266,326],[591,326],[591,367],[266,367]],"region":{"top_left_x":265,"top_left_y":326,"width":326,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8adeb1e69a6b4a18b4b650eef7f40b64","type":"simple_cell","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","text":"Pharmacokinetics","text_display":"Pharmacokinetics","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[885,324],[1864,324],[1864,422],[885,422]],"region":{"top_left_x":885,"top_left_y":324,"width":980,"height":98},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fb906b33e7a42409fc25a26228703fd","type":"complex_cell","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","children_ids":["cfc2a2619be94c9a989fd0932cee3b7e","2bbc94de67f647368fd7a956d024d213"],"text":"Levels of sprifermin/FGF-18 will be measured in serum and synovial fluid for pharmacokinetic (PK) assessment","text_display":"Levels of sprifermin/FGF-18 will be measured in serum and synovial fluid for pharmacokinetic (PK) assessment","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[887,326],[1862,326],[1862,372],[887,372]],"region":{"top_left_x":887,"top_left_y":326,"width":975,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfc2a2619be94c9a989fd0932cee3b7e","type":"text","conversion_output":false,"parent_id":"7fb906b33e7a42409fc25a26228703fd","text":"Levels of sprifermin/FGF-18 will be measured in serum","text_display":"Levels of sprifermin/FGF-18 will be measured in serum","confidence":0.99951171875,"confidence_rate":0.9999915793372107},{"cnt":[[890,374],[1829,374],[1829,419],[890,419]],"region":{"top_left_x":889,"top_left_y":373,"width":941,"height":47},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bbc94de67f647368fd7a956d024d213","type":"text","conversion_output":false,"parent_id":"7fb906b33e7a42409fc25a26228703fd","text":"and synovial fluid for pharmacokinetic (PK) assessment","text_display":" and synovial fluid for pharmacokinetic (PK) assessment","confidence":1,"confidence_rate":1},{"cnt":[[266,469],[597,469],[597,506],[266,506]],"region":{"top_left_x":265,"top_left_y":469,"width":333,"height":38},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ada1df0865594de0ba8c5c0444baf9a9","type":"simple_cell","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","text":"Other assessments","text_display":"Other assessments","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[885,463],[1873,463],[1873,835],[885,835]],"region":{"top_left_x":885,"top_left_y":462,"width":988,"height":374},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5448a639c9324156ad51724b4a7ae0d4","type":"complex_cell","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","children_ids":["800f384ea0724cf1afeb9d9cd08b2516","12a35d8fe67b40dabaaec1446930ecc0","0dcc9db6ed8d47cbb4bd27aa42340f69","0a10ecf24dc94a75a0cc1ec2485b01c4","72c3b7ef07e74209a6e6a42dd7ebef31","db3aac0a74c24c26b588395ffedec39a","0705ce4fe67c487ca0452808c8265dba"],"text":"\\begin{tabular}{l}\nSubject diary information about maximum levels of target knee pain and presence or absence of target knee swelling will be used to identify potential acute inflammatory reactions to the IMP. \\\\\nExploratory pharmacogenetic (PGt) analyses will be performed for subjects who provide separate informed consent.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nSubject diary information about maximum levels of target knee pain and presence or absence of target knee swelling will be used to identify potential acute inflammatory reactions to the IMP. \\\\\nExploratory pharmacogenetic (PGt) analyses will be performed for subjects who provide separate informed consent.\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9912109375,"confidence_rate":0.9999770706158081},{"cnt":[[890,465],[1866,465],[1866,510],[890,510]],"region":{"top_left_x":889,"top_left_y":464,"width":978,"height":47},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"800f384ea0724cf1afeb9d9cd08b2516","type":"text","conversion_output":false,"parent_id":"5448a639c9324156ad51724b4a7ae0d4","text":"Subject diary information about maximum levels of","text_display":"Subject diary information about maximum levels of","confidence":1,"confidence_rate":1},{"cnt":[[890,513],[1862,513],[1862,558],[890,558]],"region":{"top_left_x":889,"top_left_y":512,"width":973,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12a35d8fe67b40dabaaec1446930ecc0","type":"text","conversion_output":false,"parent_id":"5448a639c9324156ad51724b4a7ae0d4","text":"target knee pain and presence or absence of target knee","text_display":" target knee pain and presence or absence of target knee","confidence":1,"confidence_rate":1},{"cnt":[[890,560],[1862,560],[1862,608],[890,608]],"region":{"top_left_x":889,"top_left_y":560,"width":973,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dcc9db6ed8d47cbb4bd27aa42340f69","type":"text","conversion_output":false,"parent_id":"5448a639c9324156ad51724b4a7ae0d4","text":"swelling will be used to identify potential acute","text_display":" swelling will be used to identify potential acute","confidence":1,"confidence_rate":1},{"cnt":[[890,610],[1476,610],[1476,653],[890,653]],"region":{"top_left_x":889,"top_left_y":609,"width":588,"height":45},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a10ecf24dc94a75a0cc1ec2485b01c4","type":"text","conversion_output":false,"parent_id":"5448a639c9324156ad51724b4a7ae0d4","text":"inflammatory reactions to the IMP.","text_display":" inflammatory reactions to the IMP.","confidence":1,"confidence_rate":1},{"cnt":[[890,699],[1862,699],[1862,744],[890,744]],"region":{"top_left_x":889,"top_left_y":698,"width":973,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72c3b7ef07e74209a6e6a42dd7ebef31","type":"text","conversion_output":false,"parent_id":"5448a639c9324156ad51724b4a7ae0d4","text":"Exploratory pharmacogenetic (PGt) analyses will be","text_display":"\nExploratory pharmacogenetic (PGt) analyses will be","confidence":0.9912109375,"confidence_rate":0.999839505351125},{"cnt":[[890,746],[1862,746],[1862,792],[890,792]],"region":{"top_left_x":889,"top_left_y":746,"width":973,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db3aac0a74c24c26b588395ffedec39a","type":"text","conversion_output":false,"parent_id":"5448a639c9324156ad51724b4a7ae0d4","text":"performed for subjects who provide separate informed","text_display":" performed for subjects who provide separate informed","confidence":1,"confidence_rate":1},{"cnt":[[890,798],[1030,798],[1030,831],[890,831]],"region":{"top_left_x":889,"top_left_y":798,"width":142,"height":33},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0705ce4fe67c487ca0452808c8265dba","type":"text","conversion_output":false,"parent_id":"5448a639c9324156ad51724b4a7ae0d4","text":"consent.","text_display":" consent.","confidence":1,"confidence_rate":1},{"cnt":[[262,885],[779,885],[779,982],[262,982]],"region":{"top_left_x":261,"top_left_y":884,"width":519,"height":99},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a77b4487a254b6dbd9b57f8a8dfef3b","type":"complex_cell","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","children_ids":["87761efee6f4428eaac7b1d04fda7361","8c073f8f05fc4c869546bcd9f209c4dd"],"text":"Statistical methods (includes sample size calculation)","text_display":"Statistical methods (includes sample size calculation)","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,889],[779,889],[779,930],[266,930]],"region":{"top_left_x":265,"top_left_y":889,"width":515,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87761efee6f4428eaac7b1d04fda7361","type":"text","conversion_output":false,"parent_id":"0a77b4487a254b6dbd9b57f8a8dfef3b","text":"Statistical methods (includes","text_display":"Statistical methods (includes","confidence":1,"confidence_rate":1},{"cnt":[[266,937],[688,937],[688,982],[266,982]],"region":{"top_left_x":265,"top_left_y":936,"width":424,"height":47},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c073f8f05fc4c869546bcd9f209c4dd","type":"text","conversion_output":false,"parent_id":"0a77b4487a254b6dbd9b57f8a8dfef3b","text":"sample size calculation)","text_display":" sample size calculation)","confidence":1,"confidence_rate":1},{"cnt":[[885,883],[1866,883],[1866,2483],[885,2483]],"region":{"top_left_x":885,"top_left_y":882,"width":982,"height":1602},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4341899c5dd44e6b184b33337348aa4","type":"complex_cell","conversion_output":false,"parent_id":"20ea0cafc93d43e190a2d2b92a160390","children_ids":["75b327906fc84247aa4cfabe9c98d14b","9a39b09fc12345c8b8b4e3c2e4be8af5","4527142150cf4c649bb45f327d52c267","d052304911d34997841b1298047bc87a","5dfcfb8a0fe745cdb4dec6faccded20b","c1b9e2842f8c42ec9eb3c01931a3c040","6bdd6cf6adcd40dcb836ee9621c3ed1e","a614cc792709441fadbd8ed098934e91","95dc260106f84ed38ded5fecca973e5a","ae88a4dcfdf9467aa4f75002b2cab1ce","678da0eb16e74e339e5fa90e510ed476","5c1206699e4f447f865cef81c6fd1aa8","f7798f9414684c8691b803016c3bf51b","c0e3de4a171d4f329b7b78e757ad9190","f714ef0c53e24673b076b1ada67dad6d","9f05b3d090b44ad1976cead9e9817e3d","7cc55a33714846d89beb7ef11814fa70","302239742fbc46659c5c50a61e55db1f","6c246c62cb3f44caa6e004a5f1e2b721","18e14f3906474f31883e28b026bce626","7cd6ae91398442fd9a7744d0bb3a93f4","35295e2c791040f783affc5687c8d0e5","fd3f5e4fd5c2469bb23fceb10dbc2103","2a0194a0dd4a47688ffb3fe298326cf5","b911c2825df84d0eb7818dcb8190ff75","be588f77421247b781ab181446517f86","757557e1558f41f7b05d2dda2fa357f1","96a05dfc5bd340df8884c2a0f936b328","eabb8a68957e41fab431c7675e82b4b5"],"text":"\\begin{tabular}{l}\nSample Size Calculation \\\\\nThe number of 545 randomized subjects has been calculated to provide \\(90 \\%\\) power to detect a dose relationship as well as an overall treatment effect in the change from baseline in cartilage thickness in the total femorotibial joint at 2 years, assuming a discontinuation rate of \\(30 \\%\\) at that time. The study is also adequately powered to detect significant difference in at least one active treatment group and the placebo group for a secondary WOMAC endpoint such as the pain, function or total WOMAC score. \\\\\nStatistical Methodology \\\\\nThe treatment effect on the primary endpoint will be assessed through dose-ranging using a repeated measurement analysis of variance (ANOVA, using PROC MIXED in SAS) on absolute change from baseline, including the baseline value, the treatment group, the time, and the country as factors and treatment by time as interaction. \\\\\nThe primary efficacy analysis will consist of testing the linear dose relationship and the overall treatment effect at 2 years. The significance level will be set at \\(5 \\%\\) twosided for both tests. \\\\\nPairwise comparisons (sprifermin versus placebo, and between sprifermin dose and regimen groups) will be performed within the context of this modeling framework. For each pairwise comparison, the difference between treatments and the corresponding 95\\% confidence interval (CI) and p -value will be presented.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nSample Size Calculation \\\\\nThe number of 545 randomized subjects has been calculated to provide \\(90 \\%\\) power to detect a dose relationship as well as an overall treatment effect in the change from baseline in cartilage thickness in the total femorotibial joint at 2 years, assuming a discontinuation rate of \\(30 \\%\\) at that time. The study is also adequately powered to detect significant difference in at least one active treatment group and the placebo group for a secondary WOMAC endpoint such as the pain, function or total WOMAC score. \\\\\nStatistical Methodology \\\\\nThe treatment effect on the primary endpoint will be assessed through dose-ranging using a repeated measurement analysis of variance (ANOVA, using PROC MIXED in SAS) on absolute change from baseline, including the baseline value, the treatment group, the time, and the country as factors and treatment by time as interaction. \\\\\nThe primary efficacy analysis will consist of testing the linear dose relationship and the overall treatment effect at 2 years. The significance level will be set at \\(5 \\%\\) twosided for both tests. \\\\\nPairwise comparisons (sprifermin versus placebo, and between sprifermin dose and regimen groups) will be performed within the context of this modeling framework. For each pairwise comparison, the difference between treatments and the corresponding 95\\% confidence interval (CI) and p -value will be presented.\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.5390625,"confidence_rate":0.999313932370001},{"cnt":[[890,887],[1325,887],[1325,933],[890,933]],"region":{"top_left_x":889,"top_left_y":887,"width":436,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75b327906fc84247aa4cfabe9c98d14b","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"Sample Size Calculation","text_display":"Sample Size Calculation","confidence":1,"confidence_rate":1},{"cnt":[[890,976],[1862,976],[1862,1021],[890,1021]],"region":{"top_left_x":889,"top_left_y":975,"width":973,"height":47},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a39b09fc12345c8b8b4e3c2e4be8af5","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"The number of 545 randomized subjects has been","text_display":"\nThe number of 545 randomized subjects has been","confidence":1,"confidence_rate":1},{"cnt":[[890,1024],[1862,1024],[1862,1069],[890,1069]],"region":{"top_left_x":889,"top_left_y":1023,"width":973,"height":47},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4527142150cf4c649bb45f327d52c267","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"calculated to provide \\(90 \\%\\) power to detect a dose","text_display":" calculated to provide \\(90 \\%\\) power to detect a dose","confidence":0.9975595474243164,"confidence_rate":0.9999563681780758},{"cnt":[[890,1071],[1862,1071],[1862,1117],[890,1117]],"region":{"top_left_x":889,"top_left_y":1071,"width":973,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d052304911d34997841b1298047bc87a","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"relationship as well as an overall treatment effect in the","text_display":" relationship as well as an overall treatment effect in the","confidence":1,"confidence_rate":1},{"cnt":[[890,1119],[1862,1119],[1862,1164],[890,1164]],"region":{"top_left_x":889,"top_left_y":1118,"width":973,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5dfcfb8a0fe745cdb4dec6faccded20b","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"change from baseline in cartilage thickness in the total","text_display":" change from baseline in cartilage thickness in the total","confidence":1,"confidence_rate":1},{"cnt":[[890,1167],[1862,1167],[1862,1212],[890,1212]],"region":{"top_left_x":889,"top_left_y":1166,"width":973,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1b9e2842f8c42ec9eb3c01931a3c040","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"femorotibial joint at 2 years, assuming a discontinuation","text_display":" femorotibial joint at 2 years, assuming a discontinuation","confidence":0.99951171875,"confidence_rate":0.9999924861744118},{"cnt":[[890,1214],[1862,1214],[1862,1260],[890,1260]],"region":{"top_left_x":889,"top_left_y":1214,"width":973,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6bdd6cf6adcd40dcb836ee9621c3ed1e","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"rate of \\(30 \\%\\) at that time. The study is also adequately","text_display":" rate of \\(30 \\%\\) at that time. The study is also adequately","confidence":0.98046875,"confidence_rate":0.9996819134172388},{"cnt":[[890,1264],[1862,1264],[1862,1312],[890,1312]],"region":{"top_left_x":889,"top_left_y":1263,"width":973,"height":49},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a614cc792709441fadbd8ed098934e91","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"powered to detect significant difference in at least one","text_display":" powered to detect significant difference in at least one","confidence":1,"confidence_rate":1},{"cnt":[[890,1314],[1862,1314],[1862,1357],[890,1357]],"region":{"top_left_x":889,"top_left_y":1313,"width":973,"height":45},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95dc260106f84ed38ded5fecca973e5a","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"active treatment group and the placebo group for a","text_display":" active treatment group and the placebo group for a","confidence":1,"confidence_rate":1},{"cnt":[[890,1357],[1862,1357],[1862,1403],[890,1403]],"region":{"top_left_x":889,"top_left_y":1357,"width":973,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae88a4dcfdf9467aa4f75002b2cab1ce","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"secondary WOMAC endpoint such as the pain, function","text_display":" secondary WOMAC endpoint such as the pain, function","confidence":1,"confidence_rate":1},{"cnt":[[890,1407],[1295,1407],[1295,1446],[890,1446]],"region":{"top_left_x":889,"top_left_y":1406,"width":406,"height":40},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"678da0eb16e74e339e5fa90e510ed476","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"or total WOMAC score.","text_display":" or total WOMAC score.","confidence":1,"confidence_rate":1},{"cnt":[[890,1496],[1316,1496],[1316,1545],[890,1545]],"region":{"top_left_x":889,"top_left_y":1495,"width":428,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c1206699e4f447f865cef81c6fd1aa8","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"Statistical Methodology","text_display":"\nStatistical Methodology","confidence":1,"confidence_rate":1},{"cnt":[[890,1587],[1862,1587],[1862,1632],[890,1632]],"region":{"top_left_x":889,"top_left_y":1586,"width":973,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7798f9414684c8691b803016c3bf51b","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"The treatment effect on the primary endpoint will be","text_display":"\nThe treatment effect on the primary endpoint will be","confidence":1,"confidence_rate":1},{"cnt":[[890,1634],[1862,1634],[1862,1680],[890,1680]],"region":{"top_left_x":889,"top_left_y":1634,"width":973,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0e3de4a171d4f329b7b78e757ad9190","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"assessed through dose-ranging using a repeated","text_display":" assessed through dose-ranging using a repeated","confidence":1,"confidence_rate":1},{"cnt":[[890,1682],[1862,1682],[1862,1727],[890,1727]],"region":{"top_left_x":889,"top_left_y":1681,"width":973,"height":47},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f714ef0c53e24673b076b1ada67dad6d","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"measurement analysis of variance (ANOVA, using","text_display":" measurement analysis of variance (ANOVA, using","confidence":1,"confidence_rate":1},{"cnt":[[890,1730],[1862,1730],[1862,1775],[890,1775]],"region":{"top_left_x":889,"top_left_y":1729,"width":973,"height":47},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f05b3d090b44ad1976cead9e9817e3d","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"PROC MIXED in SAS) on absolute change from","text_display":" PROC MIXED in SAS) on absolute change from","confidence":1,"confidence_rate":1},{"cnt":[[890,1777],[1862,1777],[1862,1823],[890,1823]],"region":{"top_left_x":889,"top_left_y":1777,"width":973,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7cc55a33714846d89beb7ef11814fa70","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"baseline, including the baseline value, the treatment","text_display":" baseline, including the baseline value, the treatment","confidence":1,"confidence_rate":1},{"cnt":[[890,1825],[1862,1825],[1862,1870],[890,1870]],"region":{"top_left_x":889,"top_left_y":1824,"width":973,"height":47},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"302239742fbc46659c5c50a61e55db1f","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"group, the time, and the country as factors and treatment","text_display":" group, the time, and the country as factors and treatment","confidence":1,"confidence_rate":1},{"cnt":[[890,1872],[1264,1872],[1264,1918],[890,1918]],"region":{"top_left_x":889,"top_left_y":1872,"width":376,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c246c62cb3f44caa6e004a5f1e2b721","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"by time as interaction.","text_display":" by time as interaction.","confidence":1,"confidence_rate":1},{"cnt":[[890,1963],[1862,1963],[1862,2009],[890,2009]],"region":{"top_left_x":889,"top_left_y":1963,"width":973,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18e14f3906474f31883e28b026bce626","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"The primary efficacy analysis will consist of testing the","text_display":"\nThe primary efficacy analysis will consist of testing the","confidence":1,"confidence_rate":1},{"cnt":[[890,2011],[1862,2011],[1862,2057],[890,2057]],"region":{"top_left_x":889,"top_left_y":2011,"width":973,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7cd6ae91398442fd9a7744d0bb3a93f4","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"linear dose relationship and the overall treatment effect at","text_display":" linear dose relationship and the overall treatment effect at","confidence":1,"confidence_rate":1},{"cnt":[[890,2059],[1862,2059],[1862,2104],[890,2104]],"region":{"top_left_x":889,"top_left_y":2058,"width":973,"height":47},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35295e2c791040f783affc5687c8d0e5","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"2 years. The significance level will be set at \\(5 \\%\\) two-","text_display":" 2 years. The significance level will be set at \\(5 \\%\\) two","confidence":0.99169921875,"confidence_rate":0.999863363031107},{"cnt":[[890,2106],[1217,2106],[1217,2147],[890,2147]],"region":{"top_left_x":889,"top_left_y":2106,"width":328,"height":42},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd3f5e4fd5c2469bb23fceb10dbc2103","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"sided for both tests.","text_display":"sided for both tests.","confidence":1,"confidence_rate":1},{"cnt":[[890,2197],[1862,2197],[1862,2243],[890,2243]],"region":{"top_left_x":889,"top_left_y":2197,"width":973,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a0194a0dd4a47688ffb3fe298326cf5","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"Pairwise comparisons (sprifermin versus placebo, and","text_display":"\nPairwise comparisons (sprifermin versus placebo, and","confidence":1,"confidence_rate":1},{"cnt":[[890,2245],[1862,2245],[1862,2290],[890,2290]],"region":{"top_left_x":889,"top_left_y":2244,"width":973,"height":47},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b911c2825df84d0eb7818dcb8190ff75","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"between sprifermin dose and regimen groups) will be","text_display":" between sprifermin dose and regimen groups) will be","confidence":1,"confidence_rate":1},{"cnt":[[890,2293],[1862,2293],[1862,2338],[890,2338]],"region":{"top_left_x":889,"top_left_y":2292,"width":973,"height":47},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be588f77421247b781ab181446517f86","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"performed within the context of this modeling","text_display":" performed within the context of this modeling","confidence":1,"confidence_rate":1},{"cnt":[[890,2340],[1862,2340],[1862,2386],[890,2386]],"region":{"top_left_x":889,"top_left_y":2340,"width":973,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"757557e1558f41f7b05d2dda2fa357f1","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"framework. For each pairwise comparison, the difference","text_display":" framework. For each pairwise comparison, the difference","confidence":1,"confidence_rate":1},{"cnt":[[890,2388],[1862,2388],[1862,2433],[890,2433]],"region":{"top_left_x":889,"top_left_y":2387,"width":973,"height":47},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96a05dfc5bd340df8884c2a0f936b328","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"between treatments and the corresponding 95\\%","text_display":" between treatments and the corresponding 95\\%","confidence":0.607421875,"confidence_rate":0.9898774646557851},{"cnt":[[890,2435],[1803,2435],[1803,2481],[890,2481]],"region":{"top_left_x":889,"top_left_y":2435,"width":915,"height":46},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eabb8a68957e41fab431c7675e82b4b5","type":"text","conversion_output":false,"parent_id":"c4341899c5dd44e6b184b33337348aa4","text":"confidence interval (CI) and p -value will be presented.","text_display":" confidence interval (CI) and p -value will be presented.","confidence":0.5390625,"confidence_rate":0.9908196563695048},{"cnt":[[245,2509],[440,2509],[440,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":197,"height":37},"line":56,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3832f0e90e5c4b1fab623a21a37934df","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[389,2544],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":145,"height":46},"line":57,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"82daf98e74594568bd353f70e23cc265","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1504,2522],[1603,2522],[1603,2563],[1504,2563]],"region":{"top_left_x":1503,"top_left_y":2522,"width":100,"height":42},"line":58,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"712b6caf7b2f43a1857c2942b7229ff8","type":"page_info","conversion_output":false,"text":"24/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-025","page":25,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc30ba9e76dc4587a5d2be8856ce407b","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8957f66f53564f45b5ac0b11b82b4922","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"516ad917263a4346b09fd9ab4d5eedb0","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,271],[1884,271],[1884,849],[243,849]],"region":{"top_left_x":242,"top_left_y":270,"width":1643,"height":579},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8640ea03962e489a9b1827621f8fa5c5","type":"table","conversion_output":true,"children_ids":["11a1c3d1a9cc468c8f93f2994012ef9d","c6e1feb36b274fca9157630367b9610d","8b219423f6284d628a808e7c55d9cf2e","5250e32723a249b48953e45fbec07897"],"text":"\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\nThe same ANOVA model used for the primary endpoint will be used to assess the treatment effect on continuous secondary endpoints such as MRI endpoints, WOMAC endpoints (total, pain, function, and stiffness scores), and X-ray endpoints at each time point and over time. \\\\\nLogistic regression will be used to assess the treatment effect on the binary efficacy endpoints such as the OMERACT-OARSI responder rate. Point estimates for each pairwise comparison and corresponding 95\\% CIs and p -values will be provided.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline & \\begin{tabular}{l}\nThe same ANOVA model used for the primary endpoint will be used to assess the treatment effect on continuous secondary endpoints such as MRI endpoints, WOMAC endpoints (total, pain, function, and stiffness scores), and X-ray endpoints at each time point and over time. \\\\\nLogistic regression will be used to assess the treatment effect on the binary efficacy endpoints such as the OMERACT-OARSI responder rate. Point estimates for each pairwise comparison and corresponding 95\\% CIs and p -values will be provided.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.97412109375,"confidence_rate":0.999924231318746},{"cnt":[[245,275],[880,275],[880,848],[245,848]],"region":{"top_left_x":244,"top_left_y":275,"width":637,"height":574},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11a1c3d1a9cc468c8f93f2994012ef9d","type":"table_column","conversion_output":false,"parent_id":"8640ea03962e489a9b1827621f8fa5c5","text":"","text_display":""},{"cnt":[[870,275],[1876,275],[1876,848],[870,848]],"region":{"top_left_x":869,"top_left_y":275,"width":1008,"height":574},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6e1feb36b274fca9157630367b9610d","type":"table_column","conversion_output":false,"parent_id":"8640ea03962e489a9b1827621f8fa5c5","text":"","text_display":""},{"cnt":[[242,273],[1884,273],[1884,848],[242,848]],"region":{"top_left_x":242,"top_left_y":272,"width":1643,"height":577},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b219423f6284d628a808e7c55d9cf2e","type":"table_row","conversion_output":false,"parent_id":"8640ea03962e489a9b1827621f8fa5c5","text":"","text_display":""},{"cnt":[[878,308],[1874,308],[1874,846],[878,846]],"region":{"top_left_x":877,"top_left_y":308,"width":997,"height":538},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5250e32723a249b48953e45fbec07897","type":"complex_cell","conversion_output":false,"parent_id":"8640ea03962e489a9b1827621f8fa5c5","children_ids":["86ae81c5ac024b36b38c88f9dc6ef682","0ed10b52a6074de8bbf3980c166f107c","3879669d797c4c8e82597a64dd4ce570","2f78290351b54dab9b7913692593fd1a","ee22f76af42a4110adf10a55a1da28b7","fa43c77b8eca48989036f3e8e2509e5a","7dbb36170fcb46e59382e195676c1805","e3711dfe36614f0989f770ec1264bba9","dc0643da6d254e778397f8ea3f639caa","e6b3c351921c4fc392683647ec1b93dc"],"text":"\\begin{tabular}{l}\nThe same ANOVA model used for the primary endpoint will be used to assess the treatment effect on continuous secondary endpoints such as MRI endpoints, WOMAC endpoints (total, pain, function, and stiffness scores), and X-ray endpoints at each time point and over time. \\\\\nLogistic regression will be used to assess the treatment effect on the binary efficacy endpoints such as the OMERACT-OARSI responder rate. Point estimates for each pairwise comparison and corresponding 95\\% CIs and p -values will be provided.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nThe same ANOVA model used for the primary endpoint will be used to assess the treatment effect on continuous secondary endpoints such as MRI endpoints, WOMAC endpoints (total, pain, function, and stiffness scores), and X-ray endpoints at each time point and over time. \\\\\nLogistic regression will be used to assess the treatment effect on the binary efficacy endpoints such as the OMERACT-OARSI responder rate. Point estimates for each pairwise comparison and corresponding 95\\% CIs and p -values will be provided.\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.97412109375,"confidence_rate":0.999924231318746},{"cnt":[[883,322],[1865,322],[1865,374],[883,374]],"region":{"top_left_x":883,"top_left_y":321,"width":983,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86ae81c5ac024b36b38c88f9dc6ef682","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"The same ANOVA model used for the primary endpoint","text_display":"The same ANOVA model used for the primary endpoint","confidence":1,"confidence_rate":1},{"cnt":[[886,371],[1865,371],[1865,417],[886,417]],"region":{"top_left_x":885,"top_left_y":370,"width":981,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ed10b52a6074de8bbf3980c166f107c","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"will be used to assess the treatment effect on continuous","text_display":" will be used to assess the treatment effect on continuous","confidence":1,"confidence_rate":1},{"cnt":[[886,417],[1865,417],[1865,469],[886,469]],"region":{"top_left_x":885,"top_left_y":417,"width":981,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3879669d797c4c8e82597a64dd4ce570","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"secondary endpoints such as MRI endpoints, WOMAC","text_display":" secondary endpoints such as MRI endpoints, WOMAC","confidence":1,"confidence_rate":1},{"cnt":[[886,469],[1865,469],[1865,518],[886,518]],"region":{"top_left_x":885,"top_left_y":469,"width":981,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f78290351b54dab9b7913692593fd1a","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"endpoints (total, pain, function, and stiffness scores), and","text_display":" endpoints (total, pain, function, and stiffness scores), and","confidence":1,"confidence_rate":1},{"cnt":[[886,516],[1721,516],[1721,567],[886,567]],"region":{"top_left_x":885,"top_left_y":515,"width":836,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee22f76af42a4110adf10a55a1da28b7","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"X-ray endpoints at each time point and over time.","text_display":" X-ray endpoints at each time point and over time.","confidence":1,"confidence_rate":1},{"cnt":[[886,603],[1865,603],[1865,655],[886,655]],"region":{"top_left_x":885,"top_left_y":602,"width":981,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa43c77b8eca48989036f3e8e2509e5a","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"Logistic regression will be used to assess the treatment","text_display":"\nLogistic regression will be used to assess the treatment","confidence":1,"confidence_rate":1},{"cnt":[[886,652],[1865,652],[1865,704],[886,704]],"region":{"top_left_x":885,"top_left_y":651,"width":981,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dbb36170fcb46e59382e195676c1805","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"effect on the binary efficacy endpoints such as the","text_display":" effect on the binary efficacy endpoints such as the","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[886,698],[1868,698],[1868,753],[886,753]],"region":{"top_left_x":885,"top_left_y":698,"width":984,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3711dfe36614f0989f770ec1264bba9","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"OMERACT-OARSI responder rate. Point estimates for","text_display":" OMERACT-OARSI responder rate. Point estimates for","confidence":1,"confidence_rate":1},{"cnt":[[886,745],[1865,745],[1865,799],[886,799]],"region":{"top_left_x":885,"top_left_y":744,"width":981,"height":56},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc0643da6d254e778397f8ea3f639caa","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"each pairwise comparison and corresponding 95\\% CIs","text_display":" each pairwise comparison and corresponding 95\\% CIs","confidence":0.9931640625,"confidence_rate":0.999875291239495},{"cnt":[[886,794],[1402,794],[1402,846],[886,846]],"region":{"top_left_x":885,"top_left_y":793,"width":517,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6b3c351921c4fc392683647ec1b93dc","type":"text","conversion_output":false,"parent_id":"5250e32723a249b48953e45fbec07897","text":"and p -values will be provided.","text_display":" and p -values will be provided.","confidence":0.97412109375,"confidence_rate":0.9993759172769822},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6b502af0606040448094ad48ec9f25bb","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1504,2527],[1605,2527],[1605,2563],[1504,2563]],"region":{"top_left_x":1503,"top_left_y":2526,"width":102,"height":38},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d26d376eef054979ad40b80a3eb6d619","type":"page_info","conversion_output":false,"text":"25/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[389,2544],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":145,"height":46},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6ee776ed6bbf4efe8882e03ee9da86e9","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-026","page":26,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f93c1e9847064d71ba6e4b4e82ae3655","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4859c4ad659046fb93c269f485243a47","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e22e10abdbf4846a1885c33af91c7e8","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,320],[288,320],[288,382],[241,382]],"region":{"top_left_x":240,"top_left_y":320,"width":48,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2795f66973a148fcac16f49287befa7e","type":"section_header","conversion_output":false,"children_ids":["0acefbc0429a4ebca177dcc6a3dba103"],"text":"","text_display":""},{"cnt":[[243,312],[284,312],[284,374],[243,374]],"region":{"top_left_x":242,"top_left_y":311,"width":42,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0acefbc0429a4ebca177dcc6a3dba103","type":"text","conversion_output":true,"parent_id":"2795f66973a148fcac16f49287befa7e","text":"2","text_display":"\n\n\\section*{2}","confidence":1,"confidence_rate":1},{"cnt":[[591,322],[1818,322],[1818,385],[591,385]],"region":{"top_left_x":590,"top_left_y":322,"width":1228,"height":63},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6dcf7e493b64478cb92e988f29430156","type":"text","conversion_output":true,"text":"Sponsor, Investigators and Trial Administrative Structure","text_display":"\nSponsor, Investigators and Trial Administrative Structure","confidence":1,"confidence_rate":1},{"cnt":[[236,404],[408,404],[408,462],[236,462]],"region":{"top_left_x":236,"top_left_y":403,"width":173,"height":59},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30e8db4483184534a0f85876611260fa","type":"section_header","conversion_output":false,"children_ids":["78cd739477bc451882a84702ada19502"],"text":"","text_display":""},{"cnt":[[245,408],[402,408],[402,458],[245,458]],"region":{"top_left_x":244,"top_left_y":408,"width":158,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78cd739477bc451882a84702ada19502","type":"text","conversion_output":true,"parent_id":"30e8db4483184534a0f85876611260fa","text":"Sponsor","text_display":"\n\n\\section*{Sponsor}","confidence":1,"confidence_rate":1},{"cnt":[[245,464],[1880,464],[1880,513],[245,513]],"region":{"top_left_x":244,"top_left_y":464,"width":1636,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0355a0559fcd420180180cc80e4ae4cb","type":"text","conversion_output":true,"text":"For countries other than the United States of America, the Sponsor of this trial is Merck KGaA,","text_display":"\n\nFor countries other than the United States of America, the Sponsor of this trial is Merck KGaA,","confidence":0.99853515625,"confidence_rate":0.9999853409306202},{"cnt":[[245,511],[1141,511],[1141,563],[245,563]],"region":{"top_left_x":244,"top_left_y":511,"width":897,"height":52},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2bf671ee8ea454ab0d47fac43e7cba9","type":"text","conversion_output":true,"text":"Frankfurter Strasse 250, 64293 Darmstadt, Germany.","text_display":" Frankfurter Strasse 250, 64293 Darmstadt, Germany.","confidence":0.9990234375,"confidence_rate":0.9999831546307154},{"cnt":[[245,602],[1882,602],[1882,655],[245,655]],"region":{"top_left_x":244,"top_left_y":601,"width":1639,"height":55},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91c94315a5de4e4787b5ee1bdef8f51a","type":"text","conversion_output":true,"text":"For the United States of America, the Sponsor of this trial is EMD Serono Inc. (One Technology","text_display":"\n\nFor the United States of America, the Sponsor of this trial is EMD Serono Inc. (One Technology","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,649],[857,649],[857,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":614,"height":51},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"586025b85fe8474198e4acb91a106af7","type":"text","conversion_output":true,"text":"Place, Rockland, MA 02370, USA).","text_display":" Place, Rockland, MA 02370, USA).","confidence":1,"confidence_rate":1},{"cnt":[[241,735],[694,735],[694,797],[241,797]],"region":{"top_left_x":240,"top_left_y":734,"width":454,"height":64},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4abb8930fd554d08a4ce43bc4c1268ed","type":"section_header","conversion_output":false,"children_ids":["ef26369fbb26469289024efa2c7cac3f"],"text":"","text_display":""},{"cnt":[[245,739],[690,739],[690,793],[245,793]],"region":{"top_left_x":244,"top_left_y":739,"width":446,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef26369fbb26469289024efa2c7cac3f","type":"text","conversion_output":true,"parent_id":"4abb8930fd554d08a4ce43bc4c1268ed","text":"Sponsor Responsibilities","text_display":"\n\n\\section*{Sponsor Responsibilities}","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[1433,795],[1433,849],[245,849]],"region":{"top_left_x":244,"top_left_y":794,"width":1190,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a2effea5c024842beeefd2098be3c5c","type":"text","conversion_output":true,"text":"The sponsor will be responsible for overseeing all aspects of the study.","text_display":"\n\nThe sponsor will be responsible for overseeing all aspects of the study.","confidence":1,"confidence_rate":1},{"cnt":[[241,883],[741,883],[741,939],[241,939]],"region":{"top_left_x":240,"top_left_y":883,"width":502,"height":56},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdb53deb2d224a4fa5279a8d15f032a4","type":"section_header","conversion_output":false,"children_ids":["b96dfcfde0dd4ab7accf7ecbea160bc4"],"text":"","text_display":""},{"cnt":[[245,889],[733,889],[733,935],[245,935]],"region":{"top_left_x":244,"top_left_y":889,"width":489,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b96dfcfde0dd4ab7accf7ecbea160bc4","type":"text","conversion_output":true,"parent_id":"bdb53deb2d224a4fa5279a8d15f032a4","text":"External Service Providers","text_display":"\n\n\\section*{External Service Providers}","confidence":1,"confidence_rate":1},{"cnt":[[245,945],[1884,945],[1884,999],[245,999]],"region":{"top_left_x":244,"top_left_y":945,"width":1641,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2109a4312c814f78885840d8a51212a6","type":"text","conversion_output":true,"text":"External service providers will be responsible for trial management, including central","text_display":"\n\nExternal service providers will be responsible for trial management, including central","confidence":1,"confidence_rate":1},{"cnt":[[245,993],[1882,993],[1882,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":992,"width":1639,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e6135514b784f9e8157c2b7770dcbf0","type":"text","conversion_output":true,"text":"randomization and central laboratory analyses. Magnetic resonance imaging (MRI) and X-ray","text_display":" randomization and central laboratory analyses. Magnetic resonance imaging (MRI) and X-ray","confidence":1,"confidence_rate":1},{"cnt":[[245,1040],[1882,1040],[1882,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1039,"width":1639,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f2f3688aff44a2d8a9e04ca3d4dff65","type":"text","conversion_output":true,"text":"imaging data will also be acquired and read centrally. Details regarding the vendors involved and","text_display":" imaging data will also be acquired and read centrally. Details regarding the vendors involved and","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1212,1087],[1212,1141],[245,1141]],"region":{"top_left_x":244,"top_left_y":1087,"width":968,"height":54},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43db946b836b4205a05d4d6aa670ccc5","type":"text","conversion_output":true,"text":"the responsibilities of each will be described in the MOP.","text_display":" the responsibilities of each will be described in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[236,1173],[765,1173],[765,1235],[236,1235]],"region":{"top_left_x":236,"top_left_y":1173,"width":529,"height":63},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1d9a8e92121448884eafd28112abc98","type":"section_header","conversion_output":false,"children_ids":["accecfe6a43647c3b7296745d6f9033e"],"text":"","text_display":""},{"cnt":[[245,1177],[758,1177],[758,1231],[245,1231]],"region":{"top_left_x":244,"top_left_y":1177,"width":515,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"accecfe6a43647c3b7296745d6f9033e","type":"text","conversion_output":true,"parent_id":"a1d9a8e92121448884eafd28112abc98","text":"Investigators and Trial Sites","text_display":"\n\n\\section*{Investigators and Trial Sites}","confidence":1,"confidence_rate":1},{"cnt":[[245,1238],[1884,1238],[1884,1291],[245,1291]],"region":{"top_left_x":244,"top_left_y":1237,"width":1641,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f781d95010e4d77a4a8f63d075ecb4a","type":"text","conversion_output":true,"text":"Overall, approximately 10 to 15 trial sites located in Europe, the United States, and possibly","text_display":"\n\nOverall, approximately 10 to 15 trial sites located in Europe, the United States, and possibly","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,1285],[1154,1285],[1154,1338],[245,1338]],"region":{"top_left_x":244,"top_left_y":1284,"width":910,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d5614d5b85d4dbb9f738aaa1c783cb5","type":"text","conversion_output":true,"text":"other geographical regions will contribute to this trial.","text_display":" other geographical regions will contribute to this trial.","confidence":0.99951171875,"confidence_rate":0.999992122603638},{"cnt":[[245,1371],[1549,1371],[1549,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1370,"width":1306,"height":59},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b28017a3321c4fba99126cd7cbde2316","type":"text","conversion_output":true,"text":"It is estimated that 2 of the enrolling sites will be located in the United States.","text_display":"\n\nIt is estimated that 2 of the enrolling sites will be located in the United States.","confidence":0.9990236759185791,"confidence_rate":0.9999892659807285},{"cnt":[[241,1461],[724,1461],[724,1523],[241,1523]],"region":{"top_left_x":240,"top_left_y":1460,"width":485,"height":64},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b1ee7fa800f4080a12174d1e1c1d97e","type":"section_header","conversion_output":false,"children_ids":["2825780304304edeae0e23c3a3ecd2e1"],"text":"","text_display":""},{"cnt":[[245,1465],[720,1465],[720,1517],[245,1517]],"region":{"top_left_x":244,"top_left_y":1465,"width":476,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2825780304304edeae0e23c3a3ecd2e1","type":"text","conversion_output":true,"parent_id":"2b1ee7fa800f4080a12174d1e1c1d97e","text":"Coordinating Investigator","text_display":"\n\n\\section*{Coordinating Investigator}","confidence":1,"confidence_rate":1},{"cnt":[[245,1517],[1089,1517],[1089,1573],[245,1573]],"region":{"top_left_x":244,"top_left_y":1516,"width":846,"height":57},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ca6ab667774406b868c1470a2e0669f","type":"text","conversion_output":true,"text":"The Coordinating Investigator for this trial is PPD","text_display":"\n\nThe Coordinating Investigator for this trial is PPD","confidence":1,"confidence_rate":1},{"cnt":[[894,1618],[1882,1618],[1882,1669],[894,1669]],"region":{"top_left_x":893,"top_left_y":1617,"width":990,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00335f1f8cfc46639cca8d224a35ec54","type":"text","conversion_output":true,"text":"(contact information is provided on the title page of this","text_display":"\n(contact information is provided on the title page of this","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[629,1667],[629,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1667,"width":386,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"411cd1e18ede452f95b600a71005cfb7","type":"text","conversion_output":true,"text":"clinical trial protocol).","text_display":" clinical trial protocol).","confidence":1,"confidence_rate":1},{"cnt":[[243,1755],[1882,1755],[1882,1807],[243,1807]],"region":{"top_left_x":242,"top_left_y":1755,"width":1641,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83acd1423af24fc786a73bddab7cee94","type":"text","conversion_output":true,"text":"The Coordinating Investigator will serve as a representative of the trial Investigators in decisions","text_display":"\n\nThe Coordinating Investigator will serve as a representative of the trial Investigators in decisions","confidence":1,"confidence_rate":1},{"cnt":[[243,1805],[1880,1805],[1880,1858],[243,1858]],"region":{"top_left_x":242,"top_left_y":1804,"width":1638,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b08dd04429324b72a2647b8377c23f8a","type":"text","conversion_output":true,"text":"and discussions regarding this trial (see International Conference on Harmonization Topic E6,","text_display":" and discussions regarding this trial (see International Conference on Harmonization Topic E6,","confidence":1,"confidence_rate":1},{"cnt":[[245,1852],[1880,1852],[1880,1904],[245,1904]],"region":{"top_left_x":244,"top_left_y":1851,"width":1636,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd348cfb83c248638b39642aea5b69bf","type":"text","conversion_output":true,"text":"Good Clinical Practice (ICH GCP), 1.19), providing expert medical input and advice relating to","text_display":" Good Clinical Practice (ICH GCP), 1.19), providing expert medical input and advice relating to","confidence":1,"confidence_rate":1},{"cnt":[[243,1899],[1880,1899],[1880,1953],[243,1953]],"region":{"top_left_x":242,"top_left_y":1899,"width":1638,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1c510bdb08943a3b7b0f028d9cac4e2","type":"text","conversion_output":true,"text":"trial design and execution and being responsible for the review and sign-off of the clinical trial","text_display":" trial design and execution and being responsible for the review and sign-off of the clinical trial","confidence":1,"confidence_rate":1},{"cnt":[[245,1946],[853,1946],[853,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1946,"width":609,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfaa6307647e447e8fcef9a1c442affa","type":"text","conversion_output":true,"text":"report on behalf of all Investigators.","text_display":" report on behalf of all Investigators.","confidence":1,"confidence_rate":1},{"cnt":[[236,2032],[1003,2032],[1003,2095],[236,2095]],"region":{"top_left_x":236,"top_left_y":2032,"width":768,"height":63},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88ef41c96d9246cbb4ede3bf20aa03ab","type":"section_header","conversion_output":false,"children_ids":["f6783a9a31234fbdaeb5b1cd921dce03"],"text":"","text_display":""},{"cnt":[[245,2039],[999,2039],[999,2090],[245,2090]],"region":{"top_left_x":244,"top_left_y":2038,"width":756,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6783a9a31234fbdaeb5b1cd921dce03","type":"text","conversion_output":true,"parent_id":"88ef41c96d9246cbb4ede3bf20aa03ab","text":"Independent Data Monitoring Committee","text_display":"\n\n\\section*{Independent Data Monitoring Committee}","confidence":1,"confidence_rate":1},{"cnt":[[243,2093],[1882,2093],[1882,2146],[243,2146]],"region":{"top_left_x":242,"top_left_y":2092,"width":1641,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"182742aa105d459d89d4a642fa9eb68c","type":"text","conversion_output":true,"text":"An Independent Data Monitoring Committee (IDMC) will be constituted and will perform","text_display":"\n\nAn Independent Data Monitoring Committee (IDMC) will be constituted and will perform","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1882,2144],[1882,2196],[245,2196]],"region":{"top_left_x":244,"top_left_y":2144,"width":1639,"height":52},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb03c5b6c05d46d5b23c50b6d2c3e873","type":"text","conversion_output":true,"text":"periodic reviews to evaluate the safety of the subjects participating in the trial on an ongoing","text_display":" periodic reviews to evaluate the safety of the subjects participating in the trial on an ongoing","confidence":1,"confidence_rate":1},{"cnt":[[245,2191],[1882,2191],[1882,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2191,"width":1639,"height":55},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ee04e2845b24a339c04c556d765f4cc","type":"text","conversion_output":true,"text":"basis. Detailed description of the safety monitoring will be specified in a dedicated IDMC","text_display":" basis. Detailed description of the safety monitoring will be specified in a dedicated IDMC","confidence":1,"confidence_rate":1},{"cnt":[[245,2239],[380,2239],[380,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2238,"width":137,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2b17bde04a049adadab6e913bfecb37","type":"text","conversion_output":true,"text":"charter.","text_display":" charter.","confidence":1,"confidence_rate":1},{"cnt":[[236,2322],[814,2322],[814,2380],[236,2380]],"region":{"top_left_x":236,"top_left_y":2322,"width":579,"height":59},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edb877f1b8c149b2b2a5124bf7e8e4c4","type":"section_header","conversion_output":false,"children_ids":["b4bed277780d44a18377b1ab0cb52627"],"text":"","text_display":""},{"cnt":[[245,2329],[810,2329],[810,2374],[245,2374]],"region":{"top_left_x":244,"top_left_y":2328,"width":566,"height":47},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4bed277780d44a18377b1ab0cb52627","type":"text","conversion_output":true,"parent_id":"edb877f1b8c149b2b2a5124bf7e8e4c4","text":"Trial Administrative Structure","text_display":"\n\n\\section*{Trial Administrative Structure}","confidence":1,"confidence_rate":1},{"cnt":[[243,2385],[1882,2385],[1882,2438],[243,2438]],"region":{"top_left_x":242,"top_left_y":2384,"width":1641,"height":55},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2aee4e3867b143948a863bbeb3a4c5db","type":"text","conversion_output":true,"text":"Details of the trial's administrative structure are presented in the trial Manual of Operations","text_display":"\n\nDetails of the trial's administrative structure are presented in the trial Manual of Operations","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,2436],[380,2436],[380,2486],[245,2486]],"region":{"top_left_x":244,"top_left_y":2436,"width":137,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"379d0feccf6b4002b52967e09b752e0f","type":"text","conversion_output":true,"text":"(MOP).","text_display":" (MOP).","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":47,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4a2dccd0b39a4469b920dc92defb9754","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":48,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cec39e29986944d698d26fee001f5636","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4736b72953cc44978d72345987764e91","type":"page_info","conversion_output":false,"text":"26/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-027","page":27,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01fdead1072c4e57b715ffcdb6499331","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fbbed301d454c1eb4f7146a445ad3b1","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1cf71bbb5fd42ddacb547410d1e3607","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,318],[1137,318],[1137,389],[236,389]],"region":{"top_left_x":236,"top_left_y":317,"width":901,"height":72},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfef6c40f56c4966a493729c1205f197","type":"section_header","conversion_output":false,"children_ids":["08636eca3f8240b98fa2573f71012413","af611c9ec0894f3c87cbd364e38e0d0b"],"text":"","text_display":""},{"cnt":[[243,327],[284,327],[284,376],[243,376]],"region":{"top_left_x":242,"top_left_y":326,"width":42,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08636eca3f8240b98fa2573f71012413","type":"text","conversion_output":true,"parent_id":"dfef6c40f56c4966a493729c1205f197","text":"3","text_display":"\n\n\\section*{3","confidence":0.99951171875,"confidence_rate":0.99951171875},{"cnt":[[593,322],[1130,322],[1130,380],[593,380]],"region":{"top_left_x":592,"top_left_y":322,"width":539,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af611c9ec0894f3c87cbd364e38e0d0b","type":"text","conversion_output":true,"parent_id":"dfef6c40f56c4966a493729c1205f197","text":"Background Information","text_display":" Background Information}","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1882,417],[1882,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1639,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3da088495fe4831ae288266c0fa6b4f","type":"text","conversion_output":true,"text":"Osteoarthritis (OA) is an ever-increasing health problem in both industrialized nations and","text_display":"\n\nOsteoarthritis (OA) is an ever-increasing health problem in both industrialized nations and","confidence":0.99951171875,"confidence_rate":0.9999949125077527},{"cnt":[[245,468],[1882,468],[1882,518],[245,518]],"region":{"top_left_x":244,"top_left_y":468,"width":1639,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f16fa10ca49e4d639e1319a0193900d7","type":"text","conversion_output":true,"text":"developing countries (2). The risk factors contributing to this epidemic are increasing body","text_display":" developing countries (2). The risk factors contributing to this epidemic are increasing body","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1880,516],[1880,569],[245,569]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f2a7a9928c94310a2e9ac098d43bc84","type":"text","conversion_output":true,"text":"weight, lack of exercise, and the aging of a significant proportion of the population (3),(4),(5).","text_display":" weight, lack of exercise, and the aging of a significant proportion of the population (3),(4),(5).","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,614],[245,614]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"934eca7f805b4e45beeeebb97551dc01","type":"text","conversion_output":true,"text":"The increasing number of individuals being affected by degenerative joint disease also translates","text_display":" The increasing number of individuals being affected by degenerative joint disease also translates","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1317,610],[1317,664],[245,664]],"region":{"top_left_x":244,"top_left_y":610,"width":1073,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"767bf3c1dba94ebbaf26f8d919f9071a","type":"text","conversion_output":true,"text":"into a significant financial burden on the health care system (6).","text_display":" into a significant financial burden on the health care system (6).","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1882,700],[1882,752],[245,752]],"region":{"top_left_x":244,"top_left_y":700,"width":1639,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a600901d57e84351bd9a2cd726b8fb55","type":"text","conversion_output":true,"text":"Despite the variety of treatment modalities available, no existing pharmacological treatments can","text_display":"\n\nDespite the variety of treatment modalities available, no existing pharmacological treatments can","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[1882,748],[1882,801],[245,801]],"region":{"top_left_x":244,"top_left_y":747,"width":1639,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9abe842ede134dee819e518959fec003","type":"text","conversion_output":true,"text":"influence OA disease progression or outcome. Consequently, there is considerable interest in the","text_display":" influence OA disease progression or outcome. Consequently, there is considerable interest in the","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[1016,795],[1016,849],[245,849]],"region":{"top_left_x":244,"top_left_y":794,"width":773,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"201a6b361bbf474fa1f99a46384dacc5","type":"text","conversion_output":true,"text":"development of disease-modifying OA drugs.","text_display":" development of disease-modifying OA drugs.","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1880,885],[1880,939],[245,939]],"region":{"top_left_x":244,"top_left_y":885,"width":1636,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5aca22ff1fea4d5484d987b1548848e9","type":"text","conversion_output":true,"text":"Sprifermin is a truncated recombinant form of human fibroblast growth factor-18 (FGF-18).","text_display":"\n\nSprifermin is a truncated recombinant form of human fibroblast growth factor-18 (FGF-18).","confidence":0.99658203125,"confidence_rate":0.9999635770106784},{"cnt":[[245,932],[1880,932],[1880,986],[245,986]],"region":{"top_left_x":244,"top_left_y":932,"width":1636,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f294755e659c447f901ab017523f1b0d","type":"text","conversion_output":true,"text":"Endogenous human FGF-18 is a protein expressed by chondrocytes of articular cartilage which","text_display":" Endogenous human FGF-18 is a protein expressed by chondrocytes of articular cartilage which","confidence":1,"confidence_rate":1},{"cnt":[[245,982],[1882,982],[1882,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":981,"width":1639,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55d74928b90043958f4a40763f432edd","type":"text","conversion_output":true,"text":"has been identified as a trophic factor for mature chondrocytes. In cell culture experiments, FGF-","text_display":" has been identified as a trophic factor for mature chondrocytes. In cell culture experiments, FGF","confidence":1,"confidence_rate":1},{"cnt":[[245,1027],[1884,1027],[1884,1081],[245,1081]],"region":{"top_left_x":244,"top_left_y":1026,"width":1641,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"993d2b8c4616426aade885d117779043","type":"text","conversion_output":true,"text":"18 was shown to induce proliferation of articular chondrocytes and to stimulate synthesis of","text_display":"18 was shown to induce proliferation of articular chondrocytes and to stimulate synthesis of","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1882,1079],[1882,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1078,"width":1639,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"425e46d673e444b292dd19336d369ad7","type":"text","conversion_output":true,"text":"extracellular matrix (7). Furthermore, in an animal experiment, FGF-18 induced dose-dependent","text_display":" extracellular matrix (7). Furthermore, in an animal experiment, FGF-18 induced dose-dependent","confidence":1,"confidence_rate":1},{"cnt":[[245,1126],[1880,1126],[1880,1177],[245,1177]],"region":{"top_left_x":244,"top_left_y":1125,"width":1636,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e2045641d9e4c06b116d8603d3bc53e","type":"text","conversion_output":true,"text":"increases of cartilage thickness of the tibial plateau in rats after they had been subjected to","text_display":" increases of cartilage thickness of the tibial plateau in rats after they had been subjected to","confidence":0.9990234375,"confidence_rate":0.999990229651252},{"cnt":[[245,1173],[1882,1173],[1882,1227],[245,1227]],"region":{"top_left_x":244,"top_left_y":1173,"width":1639,"height":54},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2db04ed5d9974b1ca340e3cbc90eafdc","type":"text","conversion_output":true,"text":"meniscal injury. Both reductions in the cartilage degeneration scores and generation of new","text_display":" meniscal injury. Both reductions in the cartilage degeneration scores and generation of new","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1010,1220],[1010,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1220,"width":766,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"639508f62b6844d79901a859c413cb4e","type":"text","conversion_output":true,"text":"cartilage were seen in the treated animals (8).","text_display":" cartilage were seen in the treated animals (8).","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1880,1311],[1880,1364],[245,1364]],"region":{"top_left_x":244,"top_left_y":1310,"width":1636,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b09e9c222fe46daa753fe03e4ad8240","type":"text","conversion_output":true,"text":"Human FGF-18 is a 20-kilodalton secreted protein expressed by cells including chondrocytes","text_display":"\n\nHuman FGF-18 is a 20-kilodalton secreted protein expressed by cells including chondrocytes","confidence":0.98046875,"confidence_rate":0.9997923951807817},{"cnt":[[245,1358],[1882,1358],[1882,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1357,"width":1639,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dce4243e5f5f429fac07f16ed1e24faf","type":"text","conversion_output":true,"text":"and osteoblasts (9),(10). FGF-18 increases chondrocyte proliferation/differentiation and cartilage","text_display":" and osteoblasts (9),(10). FGF-18 increases chondrocyte proliferation/differentiation and cartilage","confidence":0.99853515625,"confidence_rate":0.9999857678907678},{"cnt":[[245,1405],[1880,1405],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":54},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddfe649aa7174f1489e09ec9219d5926","type":"text","conversion_output":true,"text":"deposition and induces osteoblast differentiation, leading to bone remodeling effects (e.g.,","text_display":" deposition and induces osteoblast differentiation, leading to bone remodeling effects (e.g.,","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,1454],[1880,1454],[1880,1506],[245,1506]],"region":{"top_left_x":244,"top_left_y":1454,"width":1636,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ff71d975878410cb08aff9fff00dd01","type":"text","conversion_output":true,"text":"closure of growth plates) (7),(8),(10),(11),(12). FGF-18 is required for normal development, as","text_display":" closure of growth plates) (7),(8),(10),(11),(12). FGF-18 is required for normal development, as","confidence":0.9680091259069741,"confidence_rate":0.9996749152099134},{"cnt":[[245,1504],[1880,1504],[1880,1555],[245,1555]],"region":{"top_left_x":244,"top_left_y":1503,"width":1636,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdf181bd23074d24b50f292836c57e0d","type":"text","conversion_output":true,"text":"homozygous knockout mice die shortly after birth (13),(14). Their phenotype includes skeletal","text_display":" homozygous knockout mice die shortly after birth (13),(14). Their phenotype includes skeletal","confidence":1,"confidence_rate":1},{"cnt":[[245,1551],[380,1551],[380,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1551,"width":137,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5162c5e9730842deb795442fc8514bb5","type":"text","conversion_output":true,"text":"defects.","text_display":" defects.","confidence":1,"confidence_rate":1},{"cnt":[[245,1637],[1882,1637],[1882,1691],[245,1691]],"region":{"top_left_x":244,"top_left_y":1637,"width":1639,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7adb91f3a3ad41f3bd027d2fabf25142","type":"text","conversion_output":true,"text":"Cell surface receptors for FGF-18 have been identified. Upon ligand binding mediated by","text_display":"\n\nCell surface receptors for FGF-18 have been identified. Upon ligand binding mediated by","confidence":1,"confidence_rate":1},{"cnt":[[245,1687],[1880,1687],[1880,1740],[245,1740]],"region":{"top_left_x":244,"top_left_y":1686,"width":1636,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54a6fd1f43b644189416343fb930cca9","type":"text","conversion_output":true,"text":"heparin/heparin sulfate-containing proteoglycans, high-affinity fibroblast growth factor receptors","text_display":" heparin/heparin sulfate-containing proteoglycans, high-affinity fibroblast growth factor receptors","confidence":1,"confidence_rate":1},{"cnt":[[245,1736],[1880,1736],[1880,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1735,"width":1636,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"239e366203f649b2aa8847670c62cd3f","type":"text","conversion_output":true,"text":"(FGFR) 3c, 4, and 2c transduce intracellular signaling via tyrosine-kinase activity (15). FGFR3c,","text_display":" (FGFR) 3c, 4, and 2c transduce intracellular signaling via tyrosine-kinase activity (15). FGFR3c,","confidence":1,"confidence_rate":1},{"cnt":[[245,1783],[1880,1783],[1880,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1783,"width":1636,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fad5d8c52855425a915de454ab1621e5","type":"text","conversion_output":true,"text":"FGFR4, and FGFR2c are naturally expressed on chondrocytes of articular cartilage, as","text_display":" FGFR4, and FGFR2c are naturally expressed on chondrocytes of articular cartilage, as","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[1880,1830],[1880,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1830,"width":1636,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb7d148fba1c4bb9b9ba69d1ea406beb","type":"text","conversion_output":true,"text":"demonstrated by in situ hybridization (14),(15). FGF-18 has been shown to signal through","text_display":" demonstrated by in situ hybridization (14),(15). FGF-18 has been shown to signal through","confidence":0.9951193332672119,"confidence_rate":0.9999473926087308},{"cnt":[[245,1880],[1880,1880],[1880,1931],[245,1931]],"region":{"top_left_x":244,"top_left_y":1879,"width":1636,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd7907932a5a444aa43d23270a50bee5","type":"text","conversion_output":true,"text":"FGFR3 to promote mesenchymal cell differentiation (chondrogenesis) and production of the","text_display":" FGFR3 to promote mesenchymal cell differentiation (chondrogenesis) and production of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1927],[1792,1927],[1792,1981],[245,1981]],"region":{"top_left_x":244,"top_left_y":1927,"width":1548,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26815ea082c7436e94b331ead142322d","type":"text","conversion_output":true,"text":"cartilage matrix, leading to repair and reconstruction of a variety of cartilaginous tissues (7).","text_display":" cartilage matrix, leading to repair and reconstruction of a variety of cartilaginous tissues (7).","confidence":1,"confidence_rate":1},{"cnt":[[245,2015],[1882,2015],[1882,2069],[245,2069]],"region":{"top_left_x":244,"top_left_y":2015,"width":1639,"height":54},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6bc7649e34af4f9aa8fda0e82177934e","type":"text","conversion_output":true,"text":"Sprifermin (recombinant human FGF-18; rhFGF-18; formerly known as AS902330) produced by","text_display":"\n\nSprifermin (recombinant human FGF-18; rhFGF-18; formerly known as AS902330) produced by","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,2065],[1880,2065],[1880,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2064,"width":1636,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2ad11613e144554b358a5c15587008a","type":"text","conversion_output":true,"text":"Merck Serono is a truncated, non-glycosylated form of FGF-18, containing 170 amino acids.","text_display":" Merck Serono is a truncated, non-glycosylated form of FGF-18, containing 170 amino acids.","confidence":0.99560546875,"confidence_rate":0.9999545967463781},{"cnt":[[245,2110],[1880,2110],[1880,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2109,"width":1636,"height":59},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c72384d2839b415c97e299b96c777cca","type":"text","conversion_output":true,"text":"Sprifermin increases chondrocyte proliferation/differentiation and cartilage deposition,","text_display":" Sprifermin increases chondrocyte proliferation/differentiation and cartilage deposition,","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,2161],[1639,2161],[1639,2213],[245,2213]],"region":{"top_left_x":244,"top_left_y":2161,"width":1396,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09ffa85dc22a4f32b3b152a03df60476","type":"text","conversion_output":true,"text":"potentially leading to repair and reconstruction of a variety of cartilaginous tissues.","text_display":" potentially leading to repair and reconstruction of a variety of cartilaginous tissues.","confidence":0.998046875,"confidence_rate":0.9999787498471376},{"cnt":[[245,2247],[1880,2247],[1880,2301],[245,2301]],"region":{"top_left_x":244,"top_left_y":2247,"width":1636,"height":54},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07d81a229e654bf3a2bf74469f45b79f","type":"text","conversion_output":true,"text":"Unlike other members of the fibroblast growth factor (FGF) family, FGF-18 is not a general","text_display":"\n\nUnlike other members of the fibroblast growth factor (FGF) family, FGF-18 is not a general","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,2299],[1880,2299],[1880,2350],[245,2350]],"region":{"top_left_x":244,"top_left_y":2298,"width":1636,"height":53},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"530018f4534244179bd13fe3117a6281","type":"text","conversion_output":true,"text":"growth mediator but exhibits its effects specifically on chondrocytes (proliferation) and","text_display":" growth mediator but exhibits its effects specifically on chondrocytes (proliferation) and","confidence":0.9990234375,"confidence_rate":0.9999896060152111},{"cnt":[[245,2346],[1882,2346],[1882,2396],[245,2396]],"region":{"top_left_x":244,"top_left_y":2346,"width":1639,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45bad9d8baab4bd4891834572be44964","type":"text","conversion_output":true,"text":"osteoblasts (differentiation). Nonetheless, significant systemic exposure to sprifermin may result","text_display":" osteoblasts (differentiation). Nonetheless, significant systemic exposure to sprifermin may result","confidence":1,"confidence_rate":1},{"cnt":[[245,2393],[1880,2393],[1880,2447],[245,2447]],"region":{"top_left_x":244,"top_left_y":2393,"width":1636,"height":55},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40858283f6124ac39a3d11f115326da5","type":"text","conversion_output":true,"text":"in unacceptable side effects such as general cartilage and bone growth. Therefore, in order to","text_display":" in unacceptable side effects such as general cartilage and bone growth. Therefore, in order to","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6e53f9cbe28b4e02ae7eb6cb5bfd9ca1","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"58503a10802b4a3984aac75ca5ddeae8","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a520249559f45fca56bdc7762f5ba34","type":"page_info","conversion_output":false,"text":"27/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-028","page":28,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ac03e57940445b9afcf033a21b7c159","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d4465325a174026a19e0a2df9f21baf","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b2b8534a1da4179bca778173748b851","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1884,279],[1884,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1641,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"190b7640b9ff442a95690706df67ba7c","type":"text","conversion_output":true,"text":"minimize systemic exposure and to limit the trophic effect of sprifermin to intra-articular","text_display":"\nminimize systemic exposure and to limit the trophic effect of sprifermin to intra-articular","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,329],[1115,329],[1115,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":872,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28c6e6f8537b409fa96584cee9b3a20f","type":"text","conversion_output":true,"text":"cartilage, intra-articular (i.a.) injection will be used.","text_display":" cartilage, intra-articular (i.a.) injection will be used.","confidence":1,"confidence_rate":1},{"cnt":[[241,415],[556,415],[556,471],[241,471]],"region":{"top_left_x":240,"top_left_y":414,"width":317,"height":57},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d29da60d55343b9baf9b8ae01ef7155","type":"section_header","conversion_output":false,"children_ids":["37bbe6d25f2c4aaa99a42b2efaff40eb"],"text":"","text_display":""},{"cnt":[[245,421],[552,421],[552,466],[245,466]],"region":{"top_left_x":244,"top_left_y":421,"width":309,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37bbe6d25f2c4aaa99a42b2efaff40eb","type":"text","conversion_output":true,"parent_id":"9d29da60d55343b9baf9b8ae01ef7155","text":"Nonclinical Data","text_display":"\n\n\\section*{Nonclinical Data}","confidence":1,"confidence_rate":1},{"cnt":[[245,507],[1880,507],[1880,556],[245,556]],"region":{"top_left_x":244,"top_left_y":507,"width":1636,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67efb6e4ca0e4801bc678f44b5dfc2ae","type":"text","conversion_output":true,"text":"Nonclinical studies performed with sprifermin are described in the sprifermin Investigator's","text_display":"\n\nNonclinical studies performed with sprifermin are described in the sprifermin Investigator's","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,554],[501,554],[501,604],[245,604]],"region":{"top_left_x":244,"top_left_y":554,"width":257,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc7c996845b6420c8c1779ae86f566e4","type":"text","conversion_output":true,"text":"Brochure (IB).","text_display":" Brochure (IB).","confidence":1,"confidence_rate":1},{"cnt":[[241,640],[496,640],[496,698],[241,698]],"region":{"top_left_x":240,"top_left_y":640,"width":257,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77b2623eae2d424fab4b317b44f18a36","type":"section_header","conversion_output":false,"children_ids":["47fa19a392aa452c8b454631480a829a"],"text":"","text_display":""},{"cnt":[[245,645],[492,645],[492,690],[245,690]],"region":{"top_left_x":244,"top_left_y":644,"width":248,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47fa19a392aa452c8b454631480a829a","type":"text","conversion_output":true,"parent_id":"77b2623eae2d424fab4b317b44f18a36","text":"Clinical Data","text_display":"\n\n\\section*{Clinical Data}","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1880,735],[1880,784],[245,784]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3151258f4334416a1280d6088a86354","type":"text","conversion_output":true,"text":"Clinical trials performed to date with sprifermin are described in the sprifermin IB. To date, two","text_display":"\n\nClinical trials performed to date with sprifermin are described in the sprifermin IB. To date, two","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1609,782],[1609,834],[245,834]],"region":{"top_left_x":244,"top_left_y":782,"width":1366,"height":52},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7615447e892642c386dc052d14104b7a","type":"text","conversion_output":true,"text":"Phase I trials of sprifermin in subjects with OA of the knee have been completed.","text_display":" Phase I trials of sprifermin in subjects with OA of the knee have been completed.","confidence":0.9505268025677651,"confidence_rate":0.9994486420638622},{"cnt":[[245,872],[1880,872],[1880,922],[245,922]],"region":{"top_left_x":244,"top_left_y":872,"width":1636,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ca0f381c7f84afaa1a88dd1bd452b33","type":"text","conversion_output":true,"text":"The randomized, double-blind, placebo-controlled multicenter first-in-man (FIM) trial 27575","text_display":"\n\nThe randomized, double-blind, placebo-controlled multicenter first-in-man (FIM) trial 27575","confidence":1,"confidence_rate":1},{"cnt":[[245,920],[1882,920],[1882,971],[245,971]],"region":{"top_left_x":244,"top_left_y":919,"width":1639,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e1f6169ac6d48de8d44eb67e56d27b4","type":"text","conversion_output":true,"text":"included 73 subjects with OA in the femorotibial compartments of the knee who were candidates","text_display":" included 73 subjects with OA in the femorotibial compartments of the knee who were candidates","confidence":0.990234375,"confidence_rate":0.9999028401515285},{"cnt":[[245,967],[1880,967],[1880,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":966,"width":1636,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"567358b0623f43edad8756cd7efb1a86","type":"text","conversion_output":true,"text":"for total knee replacement. Subjects were randomized to receive i.a. injections of sprifermin at","text_display":" for total knee replacement. Subjects were randomized to receive i.a. injections of sprifermin at","confidence":1,"confidence_rate":1},{"cnt":[[245,1016],[1882,1016],[1882,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1016,"width":1639,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b057140501d40ce9bc4e772cf65bd28","type":"text","conversion_output":true,"text":"dosages of \\(3 mcg , 10 mcg , 30 mcg , 100 mcg\\), and 300 mcg or placebo in either single-dose or","text_display":" dosages of \\(3 mcg , 10 mcg , 30 mcg , 100 mcg\\), and 300 mcg or placebo in either single-dose or","confidence":0.9263408010592684,"confidence_rate":0.9992982914838161},{"cnt":[[245,1061],[1880,1061],[1880,1115],[245,1115]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8369ae2ba95244608c78247c48dbb62d","type":"text","conversion_output":true,"text":"multiple-dose regimens. Multiple-dose regimens consisted of one treatment cycle of three","text_display":" multiple-dose regimens. Multiple-dose regimens consisted of one treatment cycle of three","confidence":0.9990234375,"confidence_rate":0.9999894942525209},{"cnt":[[245,1111],[1880,1111],[1880,1162],[245,1162]],"region":{"top_left_x":244,"top_left_y":1110,"width":1636,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a8c8dd2e76d4e838ed3ac28e3d930b0","type":"text","conversion_output":true,"text":"injections given once weekly over a period of three weeks. Twenty-three subjects who received","text_display":" injections given once weekly over a period of three weeks. Twenty-three subjects who received","confidence":1,"confidence_rate":1},{"cnt":[[245,1160],[1880,1160],[1880,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1160,"width":1636,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33e0269aa4cd4314a7addc5349b12377","type":"text","conversion_output":true,"text":"single-dose regimens and 26 subjects who received multiple-dose regimens underwent total knee","text_display":" single-dose regimens and 26 subjects who received multiple-dose regimens underwent total knee","confidence":1,"confidence_rate":1},{"cnt":[[245,1207],[1880,1207],[1880,1257],[245,1257]],"region":{"top_left_x":244,"top_left_y":1207,"width":1636,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfc3066decf54a84a46616b8b82e2099","type":"text","conversion_output":true,"text":"replacement within a period of three months after completion of treatment. When the cartilage","text_display":" replacement within a period of three months after completion of treatment. When the cartilage","confidence":1,"confidence_rate":1},{"cnt":[[245,1255],[1880,1255],[1880,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1254,"width":1636,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4dd78025a444635b61e83db1e882f21","type":"text","conversion_output":true,"text":"tissue specimens of the resected knees were examined by pathologists, specimens from subjects","text_display":" tissue specimens of the resected knees were examined by pathologists, specimens from subjects","confidence":0.99853515625,"confidence_rate":0.9999850417681765},{"cnt":[[245,1302],[1880,1302],[1880,1354],[245,1354]],"region":{"top_left_x":244,"top_left_y":1301,"width":1636,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"315d183fb48a4ea4bade6303b567aa38","type":"text","conversion_output":true,"text":"who had been exposed to dosages of 10 to 300 mcg sprifermin showed a trend to lower Mankin","text_display":" who had been exposed to dosages of 10 to 300 mcg sprifermin showed a trend to lower Mankin","confidence":0.9883203227072954,"confidence_rate":0.9998859441697779},{"cnt":[[245,1351],[1880,1351],[1880,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1351,"width":1636,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74d8511dd13e4ad7a695b5516f337d76","type":"text","conversion_output":true,"text":"scores and higher Young modulus, both indicating an improvement of cartilage morphology,","text_display":" scores and higher Young modulus, both indicating an improvement of cartilage morphology,","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1880,1401],[1880,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22a1cf5c12694925bb287510692ad833","type":"text","conversion_output":true,"text":"compared to subjects who received placebo. These effects were more pronounced in the","text_display":" compared to subjects who received placebo. These effects were more pronounced in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1446],[1880,1446],[1880,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1445,"width":1636,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fa54b2cd21040faaa5620212f71c2d8","type":"text","conversion_output":true,"text":"multiple-dose groups. Furthermore, sprifermin had a favorable safety profile and was well","text_display":" multiple-dose groups. Furthermore, sprifermin had a favorable safety profile and was well","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,1495],[599,1495],[599,1540],[245,1540]],"region":{"top_left_x":244,"top_left_y":1495,"width":356,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32902db2901f4a46a36e11d4482ccc50","type":"text","conversion_output":true,"text":"tolerated in this trial.","text_display":" tolerated in this trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,1583],[1880,1583],[1880,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1583,"width":1636,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4edd3056b3f143c88724b6d6c4f65c75","type":"text","conversion_output":true,"text":"The randomized, double-blind, placebo-controlled, multicenter proof-of-concept (POC) trial","text_display":"\n\nThe randomized, double-blind, placebo-controlled, multicenter proof-of-concept (POC) trial","confidence":1,"confidence_rate":1},{"cnt":[[245,1633],[1880,1633],[1880,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee228e1172e74d978beae6e743c4dd14","type":"text","conversion_output":true,"text":"28980 included 192 subjects with primary knee OA and Kellgren-Lawrence grade 2 or 3 who","text_display":" 28980 included 192 subjects with primary knee OA and Kellgren-Lawrence grade 2 or 3 who","confidence":0.99072265625,"confidence_rate":0.9999067978802516},{"cnt":[[245,1680],[1880,1680],[1880,1729],[245,1729]],"region":{"top_left_x":244,"top_left_y":1680,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ce00e58035d4c83a81a19c5a0a57598","type":"text","conversion_output":true,"text":"were not candidates for knee replacement. Subjects were randomized into groups receiving either","text_display":" were not candidates for knee replacement. Subjects were randomized into groups receiving either","confidence":1,"confidence_rate":1},{"cnt":[[243,1727],[1880,1727],[1880,1781],[243,1781]],"region":{"top_left_x":242,"top_left_y":1727,"width":1638,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c045ff8b4d10494686d14c3c8302b31a","type":"text","conversion_output":true,"text":"placebo or three dosages of sprifermin ( \\(10 mcg , 30 mcg\\) or 100 mcg ) in either single-dose or","text_display":" placebo or three dosages of sprifermin ( \\(10 mcg , 30 mcg\\) or 100 mcg ) in either single-dose or","confidence":0.9824716842267662,"confidence_rate":0.9998377768680409},{"cnt":[[245,1777],[1880,1777],[1880,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1776,"width":1636,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b900e0d360854b5a8c8cc65de28851c3","type":"text","conversion_output":true,"text":"multiple-dose regimens. Multiple-dose regimens involved two treatment cycles given 3 months","text_display":" multiple-dose regimens. Multiple-dose regimens involved two treatment cycles given 3 months","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[346,1826],[346,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1826,"width":102,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"630de7cc0bcd413f981ef80cdf4f7ff2","type":"text","conversion_output":true,"text":"apart.","text_display":" apart.","confidence":1,"confidence_rate":1},{"cnt":[[243,1912],[1880,1912],[1880,1966],[243,1966]],"region":{"top_left_x":242,"top_left_y":1912,"width":1638,"height":54},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cb9349798e74f489d2157c53a1f1811","type":"text","conversion_output":true,"text":"A dose-dependent anabolic effect was seen on total cartilage volume and thickness as measured","text_display":"\n\nA dose-dependent anabolic effect was seen on total cartilage volume and thickness as measured","confidence":1,"confidence_rate":1},{"cnt":[[245,1962],[1880,1962],[1880,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1961,"width":1636,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bb204b11d4545d9b15b6b85391f92f8","type":"text","conversion_output":true,"text":"by MRI. The effect on structure was more pronounced in the lateral as compared to the medial","text_display":" by MRI. The effect on structure was more pronounced in the lateral as compared to the medial","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1880,2007],[1880,2060],[245,2060]],"region":{"top_left_x":244,"top_left_y":2006,"width":1636,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25861e8e2ba147fcad164a862dfe5451","type":"text","conversion_output":true,"text":"compartment; statistical significance was not reached for the primary endpoint of change from","text_display":" compartment; statistical significance was not reached for the primary endpoint of change from","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[245,2058],[1882,2058],[1882,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":1639,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35a995bf48844882a25e8bd2ddc524ac","type":"text","conversion_output":true,"text":"baseline in cartilage thickness in the central medial femorotibial compartment. A significant","text_display":" baseline in cartilage thickness in the central medial femorotibial compartment. A significant","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1880,2105],[1880,2155],[245,2155]],"region":{"top_left_x":244,"top_left_y":2105,"width":1636,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a372acbcc8834780a84624a3fc8d67a9","type":"text","conversion_output":true,"text":"dose-dependent effect was also seen for JSW, particularly in the lateral compartment, with the","text_display":" dose-dependent effect was also seen for JSW, particularly in the lateral compartment, with the","confidence":1,"confidence_rate":1},{"cnt":[[245,2153],[1149,2153],[1149,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2152,"width":906,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbf251fa2cf3405b9621023e5ba14d15","type":"text","conversion_output":true,"text":"highest dose actually reversing joint space narrowing.","text_display":" highest dose actually reversing joint space narrowing.","confidence":1,"confidence_rate":1},{"cnt":[[245,2243],[1880,2243],[1880,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2242,"width":1636,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebe36ec8bf1d47539bf32ae8bb7d68aa","type":"text","conversion_output":true,"text":"No local tolerability or systemic safety concerns were identified. One SAE was considered","text_display":"\n\nNo local tolerability or systemic safety concerns were identified. One SAE was considered","confidence":0.99658203125,"confidence_rate":0.9999635770106784},{"cnt":[[245,2290],[1880,2290],[1880,2344],[245,2344]],"region":{"top_left_x":244,"top_left_y":2290,"width":1636,"height":54},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42f77d8963c849c78341a48a2afd3685","type":"text","conversion_output":true,"text":"potentially treatment-related: bacterial arthritis in a subject who had received placebo. Subjects","text_display":" potentially treatment-related: bacterial arthritis in a subject who had received placebo. Subjects","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,2340],[1880,2340],[1880,2391],[245,2391]],"region":{"top_left_x":244,"top_left_y":2339,"width":1636,"height":53},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a0030ec4cce45029c372d2ce8728902","type":"text","conversion_output":true,"text":"who received active treatment appeared to have slightly more acute inflammatory reactions","text_display":" who received active treatment appeared to have slightly more acute inflammatory reactions","confidence":0.9990234375,"confidence_rate":0.9999896060152111},{"cnt":[[245,2385],[1880,2385],[1880,2436],[245,2436]],"region":{"top_left_x":244,"top_left_y":2384,"width":1636,"height":53},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fbbbd165533433ab2ace915481b14dc","type":"text","conversion_output":true,"text":"(AIRs; defined as increase of pain by 30 mm on a \\(100- mm\\) visual analogue scale (VAS)","text_display":" (AIRs; defined as increase of pain by 30 mm on a \\(100- mm\\) visual analogue scale (VAS)","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,2434],[1880,2434],[1880,2486],[245,2486]],"region":{"top_left_x":244,"top_left_y":2434,"width":1636,"height":52},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcb0d5a96aab4804b26658fbe1d4622d","type":"text","conversion_output":true,"text":"associated with a self-reported synovial fluid effusion within 3 days following i.a. injection) in","text_display":" associated with a self-reported synovial fluid effusion within 3 days following i.a. injection) in","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4209ee48263f4eddbbcbb728b4aba470","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2544],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":43},"line":46,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8d50f7ca7cab416280d42a7d63ac43e6","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b9c9df8e170490c9d03cf78f1423d6a","type":"page_info","conversion_output":false,"text":"28/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-029","page":29,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"122716ec08c84371a2fafa84f10401dc","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4b25464bd574c9baea5a64ebacb9a78","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6debc64d0189483db4b71a5ae824d5a8","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58d5a8114a8d49c8b8d0371def0697e6","type":"text","conversion_output":true,"text":"the treated knee; however, no dose-response relationship was evident. For additional updated","text_display":"\nthe treated knee; however, no dose-response relationship was evident. For additional updated","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1420,329],[1420,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1177,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b5c224a63af44f09e305cdbd3161a80","type":"text","conversion_output":true,"text":"clinical safety data on sprifermin, refer to the Investigator's Brochure.","text_display":" clinical safety data on sprifermin, refer to the Investigator's Brochure.","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1880,417],[1880,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2f81cbca0914780843294598a1ac83b","type":"text","conversion_output":true,"text":"In terms of modification of symptoms, WOMAC total score improved over the 12 -month period","text_display":"\n\nIn terms of modification of symptoms, WOMAC total score improved over the 12 -month period","confidence":0.85205078125,"confidence_rate":0.9983675670182796},{"cnt":[[245,466],[1880,466],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1636,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ffaa586b5ce40589d31e7549c3c763e","type":"text","conversion_output":true,"text":"in all groups, including placebo. The improvement of symptoms was most pronounced in the","text_display":" in all groups, including placebo. The improvement of symptoms was most pronounced in the","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1880,511],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":511,"width":1636,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"294dc7c5260c417199c59bf0a64f1c30","type":"text","conversion_output":true,"text":"placebo group, while sprifermin-treated subjects experienced less symptom relief. This","text_display":" placebo group, while sprifermin-treated subjects experienced less symptom relief. This","confidence":1,"confidence_rate":1},{"cnt":[[245,561],[1880,561],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":560,"width":1636,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6955f665fd004da280488894e87a899c","type":"text","conversion_output":true,"text":"unexpected result was also seen for the WOMAC pain and function index scores and requires","text_display":" unexpected result was also seen for the WOMAC pain and function index scores and requires","confidence":1,"confidence_rate":1},{"cnt":[[245,608],[604,608],[604,660],[245,660]],"region":{"top_left_x":244,"top_left_y":608,"width":360,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1669479f7f64762a8e07183b90eaea7","type":"text","conversion_output":true,"text":"further investigation.","text_display":" further investigation.","confidence":1,"confidence_rate":1},{"cnt":[[236,692],[810,692],[810,752],[236,752]],"region":{"top_left_x":236,"top_left_y":691,"width":574,"height":61},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b92053e2ea714b8bae1bf251c3a79f97","type":"section_header","conversion_output":false,"children_ids":["3999ddb2da8a476bacb8a70d99f85496"],"text":"","text_display":""},{"cnt":[[245,700],[801,700],[801,746],[245,746]],"region":{"top_left_x":244,"top_left_y":700,"width":558,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3999ddb2da8a476bacb8a70d99f85496","type":"text","conversion_output":true,"parent_id":"b92053e2ea714b8bae1bf251c3a79f97","text":"Rationale for the Present Trial","text_display":"\n\n\\section*{Rationale for the Present Trial}","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[1882,786],[1882,840],[245,840]],"region":{"top_left_x":244,"top_left_y":786,"width":1639,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bfb1d9d099f46ee8d6c2f6cfcee5bec","type":"text","conversion_output":true,"text":"Sprifermin is a completely novel compound in the field of degenerative joint disease and it may","text_display":"\n\nSprifermin is a completely novel compound in the field of degenerative joint disease and it may","confidence":0.8492674827575684,"confidence_rate":0.9983675230820046},{"cnt":[[245,836],[1528,836],[1528,887],[245,887]],"region":{"top_left_x":244,"top_left_y":835,"width":1284,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0e9b9792af0433bbfa493faa8cbbcbe","type":"text","conversion_output":true,"text":"be the first disease-modifying drug to become available to patients with OA .","text_display":" be the first disease-modifying drug to become available to patients with OA .","confidence":0.9931640625,"confidence_rate":0.999922055202048},{"cnt":[[245,924],[1880,924],[1880,978],[245,978]],"region":{"top_left_x":244,"top_left_y":923,"width":1636,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89a5c4d6a9d746adba50419bba5da9a7","type":"text","conversion_output":true,"text":"Based on the results described above, this phase II trial is proposed to assess the dose-response-","text_display":"\n\nBased on the results described above, this phase II trial is proposed to assess the dose-response","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,973],[1880,973],[1880,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":973,"width":1636,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b506b52a07d48c6aafc1c0dc0897782","type":"text","conversion_output":true,"text":"relationship of sprifermin in subjects with knee OA of Kellgren-Lawrence grades 2 and 3. The","text_display":"relationship of sprifermin in subjects with knee OA of Kellgren-Lawrence grades 2 and 3. The","confidence":0.9877986907958984,"confidence_rate":0.9998772439726363},{"cnt":[[245,1023],[1880,1023],[1880,1072],[245,1072]],"region":{"top_left_x":244,"top_left_y":1022,"width":1636,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be678a4c3e554e3d91d67951a4da4bc4","type":"text","conversion_output":true,"text":"trial design is presented in Section 5.1; rationales for choices of trial design, subject population,","text_display":" trial design is presented in Section 5.1; rationales for choices of trial design, subject population,","confidence":0.9990234375,"confidence_rate":0.9999907826873115},{"cnt":[[245,1070],[1880,1070],[1880,1121],[245,1121]],"region":{"top_left_x":244,"top_left_y":1069,"width":1636,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca3e2422b9ce400b85faa7d353a7f140","type":"text","conversion_output":true,"text":"dose regimen, and trial assessments are presented in Section 5.2, and the reasoning behind the","text_display":" dose regimen, and trial assessments are presented in Section 5.2, and the reasoning behind the","confidence":1,"confidence_rate":1},{"cnt":[[245,1117],[1214,1117],[1214,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1117,"width":970,"height":54},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a34321137e1f4e84b84989c095c28844","type":"text","conversion_output":true,"text":"choice of planned sample size is presented in Section 8.1.","text_display":" choice of planned sample size is presented in Section 8.1.","confidence":1,"confidence_rate":1},{"cnt":[[245,1205],[1882,1205],[1882,1259],[245,1259]],"region":{"top_left_x":244,"top_left_y":1205,"width":1639,"height":54},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc681b7a47a440a7a865c3a43200f7ed","type":"text","conversion_output":true,"text":"This clinical trial will be conducted in compliance with the clinical trial protocol, Good Clinical","text_display":"\n\nThis clinical trial will be conducted in compliance with the clinical trial protocol, Good Clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,1255],[1497,1255],[1497,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1254,"width":1254,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7121fff70a6a4edc80b2b67265a27963","type":"text","conversion_output":true,"text":"Practice (ICH Topic E6, GCP) and the applicable regulatory requirements.","text_display":" Practice (ICH Topic E6, GCP) and the applicable regulatory requirements.","confidence":1,"confidence_rate":1},{"cnt":[[245,1345],[1884,1345],[1884,1396],[245,1396]],"region":{"top_left_x":244,"top_left_y":1344,"width":1641,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"515e33f33f0c48089c3114596db956a3","type":"text","conversion_output":true,"text":"If the trial is positive, it will provide data on an optimized dose and dosing schedule of","text_display":"\n\nIf the trial is positive, it will provide data on an optimized dose and dosing schedule of","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[1882,1392],[1882,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1392,"width":1639,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c97feabaf3dd4811b5ac0a3392bac7b6","type":"text","conversion_output":true,"text":"sprifermin, i.e., a dose and dosing schedule of the drug that will exert a disease-modifying action","text_display":" sprifermin, i.e., a dose and dosing schedule of the drug that will exert a disease-modifying action","confidence":0.99755859375,"confidence_rate":0.9999764965133096},{"cnt":[[245,1439],[1394,1439],[1394,1493],[245,1493]],"region":{"top_left_x":244,"top_left_y":1439,"width":1151,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"529208b6b8b14458a79df64b3a57c0c9","type":"text","conversion_output":true,"text":"(i.e., both modification of structure and improvement of symptoms).","text_display":" (i.e., both modification of structure and improvement of symptoms).","confidence":0.85986328125,"confidence_rate":0.9979052265835632},{"cnt":[[245,1530],[1882,1530],[1882,1583],[245,1583]],"region":{"top_left_x":244,"top_left_y":1529,"width":1639,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41a483a1d34c4cbfb416d50a9406e463","type":"text","conversion_output":true,"text":"Currently very little is known about how modification of structure is linked to change in","text_display":"\n\nCurrently very little is known about how modification of structure is linked to change in","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1882,1577],[1882,1631],[245,1631]],"region":{"top_left_x":244,"top_left_y":1576,"width":1639,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e24ade0ba3cc40c8ac34e09feddb5a3f","type":"text","conversion_output":true,"text":"symptoms (i.e., perception of pain and function by the subject). This trial will also help to","text_display":" symptoms (i.e., perception of pain and function by the subject). This trial will also help to","confidence":0.9926791191101074,"confidence_rate":0.9999250251571927},{"cnt":[[245,1626],[1622,1626],[1622,1678],[245,1678]],"region":{"top_left_x":244,"top_left_y":1626,"width":1379,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36552c0b69db4f36aa9a330aeb20d9a2","type":"text","conversion_output":true,"text":"understand how change in cartilage structure correlates with change in symptoms.","text_display":" understand how change in cartilage structure correlates with change in symptoms.","confidence":1,"confidence_rate":1},{"cnt":[[245,1714],[1880,1714],[1880,1768],[245,1768]],"region":{"top_left_x":244,"top_left_y":1714,"width":1636,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa8e47d4ee4a42d59697ea3b154566cf","type":"text","conversion_output":true,"text":"To date, a total of 265 subjects have been included in the FIM and the POC trials using i.a.","text_display":"\n\nTo date, a total of 265 subjects have been included in the FIM and the POC trials using i.a.","confidence":1,"confidence_rate":1},{"cnt":[[245,1764],[1880,1764],[1880,1815],[245,1815]],"region":{"top_left_x":244,"top_left_y":1763,"width":1636,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"122fc96f83394ab5aec54b3cd68c343f","type":"text","conversion_output":true,"text":"administration. All systemic levels of sprifermin/FGF-18 measured to date have been below the","text_display":" administration. All systemic levels of sprifermin/FGF-18 measured to date have been below the","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,1813],[1880,1813],[1880,1863],[245,1863]],"region":{"top_left_x":244,"top_left_y":1813,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e97f1afcefda42038b965568320a7a87","type":"text","conversion_output":true,"text":"lower limit of quantitation (LLOQ), and no local or systemic safety issues have emerged. No","text_display":" lower limit of quantitation (LLOQ), and no local or systemic safety issues have emerged. No","confidence":1,"confidence_rate":1},{"cnt":[[245,1858],[1882,1858],[1882,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1858,"width":1639,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81445ac7a8c74ad480886e7911ede1f3","type":"text","conversion_output":true,"text":"systemic antibodies to sprifermin/FGF-18 have been detected, except in 3 subjects who already","text_display":" systemic antibodies to sprifermin/FGF-18 have been detected, except in 3 subjects who already","confidence":1,"confidence_rate":1},{"cnt":[[245,1908],[1884,1908],[1884,1957],[245,1957]],"region":{"top_left_x":244,"top_left_y":1907,"width":1641,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9ed1b3b7179487da7672e2190ae7a91","type":"text","conversion_output":true,"text":"tested positive for binding antibodies at baseline. There may be a slightly higher incidence of","text_display":" tested positive for binding antibodies at baseline. There may be a slightly higher incidence of","confidence":1,"confidence_rate":1},{"cnt":[[245,1955],[1882,1955],[1882,2007],[245,2007]],"region":{"top_left_x":244,"top_left_y":1955,"width":1639,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfd6166d098c45a2888c4273b5cc6209","type":"text","conversion_output":true,"text":"AIRs in the target knee with dosages of 300 mcg sprifermin; however, the 300 mcg dosage will","text_display":" AIRs in the target knee with dosages of 300 mcg sprifermin; however, the 300 mcg dosage will","confidence":0.99658203125,"confidence_rate":0.9999680021628804},{"cnt":[[245,2002],[1882,2002],[1882,2054],[245,2054]],"region":{"top_left_x":244,"top_left_y":2002,"width":1639,"height":52},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd6ec57c02484a4ebb5001f39d0db673","type":"text","conversion_output":true,"text":"not be used in this trial. Considering all clinical and non-clinical experience, sprifermin can be","text_display":" not be used in this trial. Considering all clinical and non-clinical experience, sprifermin can be","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,2052],[1008,2052],[1008,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2051,"width":764,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abf45edb85ad4ea4985cfc0fb5240d94","type":"text","conversion_output":true,"text":"regarded as having a favorable safety profile.","text_display":" regarded as having a favorable safety profile.","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1880,2140],[1880,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2139,"width":1636,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f84f686b7fb48058bd7b300a46a3af1","type":"text","conversion_output":true,"text":"The risk-benefit relationship has been carefully considered in the planning of the trial. Based on","text_display":"\n\nThe risk-benefit relationship has been carefully considered in the planning of the trial. Based on","confidence":1,"confidence_rate":1},{"cnt":[[245,2189],[1882,2189],[1882,2241],[245,2241]],"region":{"top_left_x":244,"top_left_y":2189,"width":1639,"height":52},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4da1f2ce7dd9421eab48d82eb1596f00","type":"text","conversion_output":true,"text":"the pre-clinical and clinical data available to date, the conduct of the trial is considered justifiable","text_display":" the pre-clinical and clinical data available to date, the conduct of the trial is considered justifiable","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[245,2237],[1880,2237],[1880,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2236,"width":1636,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c8ac160646c422eaf1971c6f67726bb","type":"text","conversion_output":true,"text":"using the doses and dosage regimen of the Investigational Medicinal Product (IMP) as specified","text_display":" using the doses and dosage regimen of the Investigational Medicinal Product (IMP) as specified","confidence":1,"confidence_rate":1},{"cnt":[[245,2282],[728,2282],[728,2335],[245,2335]],"region":{"top_left_x":244,"top_left_y":2281,"width":485,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecc0575634a046ff978bea3dc2beb66f","type":"text","conversion_output":true,"text":"in this clinical trial protocol.","text_display":" in this clinical trial protocol.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7171a0c38fbe4ea9a42b4ab6e6242531","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":42},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"99d3ff425a734aa0b7383177b55fb0b5","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6a4fc853c8c4c5d8609f85c12b50ba2","type":"page_info","conversion_output":false,"text":"29/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-030","page":30,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de36e58734424bcdbb66c2ba7f3e4bec","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d9bb750024e49acaaf8cba1affd1aab","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30fd9f036df747ae9c1b517d51fde980","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,275],[947,275],[947,348],[236,348]],"region":{"top_left_x":236,"top_left_y":275,"width":712,"height":74},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3bdbb6b6b8b417d95132f62fc7eae2e","type":"section_header","conversion_output":false,"children_ids":["11aab84e879c48ab9d045fe1099e94f0","301db35d2ab84a5ab9981ff9814e79ff"],"text":"","text_display":""},{"cnt":[[243,277],[275,277],[275,335],[243,335]],"region":{"top_left_x":242,"top_left_y":277,"width":33,"height":59},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11aab84e879c48ab9d045fe1099e94f0","type":"text","conversion_output":true,"parent_id":"e3bdbb6b6b8b417d95132f62fc7eae2e","text":"4","text_display":"\n\n\\section*{4","confidence":1,"confidence_rate":1},{"cnt":[[593,284],[943,284],[943,342],[593,342]],"region":{"top_left_x":592,"top_left_y":283,"width":352,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"301db35d2ab84a5ab9981ff9814e79ff","type":"text","conversion_output":true,"parent_id":"e3bdbb6b6b8b417d95132f62fc7eae2e","text":"Trial Objectives","text_display":" Trial Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[245,378],[857,378],[857,432],[245,432]],"region":{"top_left_x":244,"top_left_y":378,"width":614,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b424e1d1a215447c8f353eb013dd3113","type":"text","conversion_output":true,"text":"The trial's objectives are as follows.","text_display":"\n\nThe trial's objectives are as follows.","confidence":0.99853515625,"confidence_rate":0.9999659094722},{"cnt":[[241,464],[410,464],[410,526],[241,526]],"region":{"top_left_x":240,"top_left_y":464,"width":171,"height":63},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e84040d93b045de999341a0e6106a04","type":"section_header","conversion_output":false,"children_ids":["5dc3e392847747a0a70b3c9e549f138f"],"text":"","text_display":""},{"cnt":[[245,468],[406,468],[406,522],[245,522]],"region":{"top_left_x":244,"top_left_y":468,"width":163,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5dc3e392847747a0a70b3c9e549f138f","type":"text","conversion_output":true,"parent_id":"9e84040d93b045de999341a0e6106a04","text":"Primary","text_display":"\n\n\\section*{Primary}","confidence":1,"confidence_rate":1},{"cnt":[[245,537],[1884,537],[1884,591],[245,591]],"region":{"top_left_x":244,"top_left_y":537,"width":1641,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e975d5e3c3246eaa818fbb4007fb9de","type":"text","conversion_output":true,"text":"- To evaluate structural changes in cartilage thickness in the total femorotibial joint of the target","text_display":"\n- To evaluate structural changes in cartilage thickness in the total femorotibial joint of the target","confidence":1,"confidence_rate":1},{"cnt":[[292,589],[862,589],[862,638],[292,638]],"region":{"top_left_x":292,"top_left_y":588,"width":570,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c490767b3844e4189d38827b4a6ec2e","type":"text","conversion_output":true,"text":"knee in terms of imaging by MRI","text_display":" knee in terms of imaging by MRI","confidence":1,"confidence_rate":1},{"cnt":[[236,670],[449,670],[449,737],[236,737]],"region":{"top_left_x":236,"top_left_y":670,"width":214,"height":67},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0e8866b08134955910553b3d7a33af4","type":"section_header","conversion_output":false,"children_ids":["4f58ce4749fd4f83acf0ebb517b140fa"],"text":"","text_display":""},{"cnt":[[245,679],[445,679],[445,728],[245,728]],"region":{"top_left_x":244,"top_left_y":678,"width":201,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f58ce4749fd4f83acf0ebb517b140fa","type":"text","conversion_output":true,"parent_id":"d0e8866b08134955910553b3d7a33af4","text":"Secondary","text_display":"\n\n\\section*{Secondary}","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[1132,748],[1132,801],[245,801]],"region":{"top_left_x":244,"top_left_y":747,"width":889,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc7fd672aee74e34ab7a4c22ae635d27","type":"text","conversion_output":true,"text":"- To evaluate different dose regimens of sprifermin","text_display":"\n- To evaluate different dose regimens of sprifermin","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[986,821],[986,874],[245,874]],"region":{"top_left_x":244,"top_left_y":820,"width":743,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7a5bd7e28b8465b9234274e9355ef1d","type":"text","conversion_output":true,"text":"- To evaluate changes in symptoms of OA","text_display":"\n- To evaluate changes in symptoms of OA","confidence":1,"confidence_rate":1},{"cnt":[[245,889],[1343,889],[1343,947],[245,947]],"region":{"top_left_x":244,"top_left_y":889,"width":1099,"height":59},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ab6744cbd5748a8b5d579267e8deebc","type":"text","conversion_output":true,"text":"- To evaluate changes in structure in terms of imaging by X-ray","text_display":"\n- To evaluate changes in structure in terms of imaging by X-ray","confidence":1,"confidence_rate":1},{"cnt":[[245,962],[1876,962],[1876,1018],[245,1018]],"region":{"top_left_x":244,"top_left_y":962,"width":1632,"height":57},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dac2b3db462f481185b87a3d09e54110","type":"text","conversion_output":true,"text":"- To evaluate other changes in cartilage morphology in terms of imaging by MRI (sub-regions)","text_display":"\n- To evaluate other changes in cartilage morphology in terms of imaging by MRI (sub-regions)","confidence":1,"confidence_rate":1},{"cnt":[[245,1036],[1042,1036],[1042,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1035,"width":798,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f820efb01c5435abcf6e7ae6f73b859","type":"text","conversion_output":true,"text":"- To evaluate changes in physical functioning","text_display":"\n- To evaluate changes in physical functioning","confidence":1,"confidence_rate":1},{"cnt":[[245,1109],[904,1109],[904,1162],[245,1162]],"region":{"top_left_x":244,"top_left_y":1108,"width":661,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2c77a8ba4174c818e4d7487937096f4","type":"text","conversion_output":true,"text":"- To evaluate the safety of sprifermin","text_display":"\n- To evaluate the safety of sprifermin","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1755,1177],[1755,1233],[245,1233]],"region":{"top_left_x":244,"top_left_y":1177,"width":1512,"height":57},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fa54cdd21f24e6a82cb977968ed27e8","type":"text","conversion_output":true,"text":"- To evaluate the PK of sprifermin in serum and in synovial fluid following i.a. injection","text_display":"\n- To evaluate the PK of sprifermin in serum and in synovial fluid following i.a. injection","confidence":0.9990236759185791,"confidence_rate":0.9999897179371111},{"cnt":[[236,1263],[479,1263],[479,1326],[236,1326]],"region":{"top_left_x":236,"top_left_y":1263,"width":244,"height":63},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e71ecc43a31f439fa168017de1dac5d9","type":"section_header","conversion_output":false,"children_ids":["35ee78c29daa4ed89ff939d81170fa6a"],"text":"","text_display":""},{"cnt":[[245,1268],[473,1268],[473,1321],[245,1321]],"region":{"top_left_x":244,"top_left_y":1267,"width":229,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35ee78c29daa4ed89ff939d81170fa6a","type":"text","conversion_output":true,"parent_id":"e71ecc43a31f439fa168017de1dac5d9","text":"Exploratory","text_display":"\n\n\\section*{Exploratory}","confidence":1,"confidence_rate":1},{"cnt":[[245,1341],[1027,1341],[1027,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1340,"width":783,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fee8a605b8a47e2bda0b54b901664f1","type":"text","conversion_output":true,"text":"- To evaluate responder criteria in symptoms","text_display":"\n- To evaluate responder criteria in symptoms","confidence":1,"confidence_rate":1},{"cnt":[[245,1412],[1712,1412],[1712,1467],[245,1467]],"region":{"top_left_x":244,"top_left_y":1411,"width":1469,"height":57},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e43c14bf40ce446b803a239c2f1b6efc","type":"text","conversion_output":true,"text":"- To explore treatment effect on OA pain and other patient-reported outcomes (PROs)","text_display":"\n- To explore treatment effect on OA pain and other patient-reported outcomes (PROs)","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1046,1482],[1046,1538],[245,1538]],"region":{"top_left_x":244,"top_left_y":1482,"width":803,"height":57},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb856062742f455082b83404d927c7e5","type":"text","conversion_output":true,"text":"- To evaluate changes in quality of life (QOL)","text_display":"\n- To evaluate changes in quality of life (QOL)","confidence":1,"confidence_rate":1},{"cnt":[[245,1555],[1588,1555],[1588,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1555,"width":1344,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f69602c3b654740aab41ae76c339c01","type":"text","conversion_output":true,"text":"- To explore the treatment effect on the knee joint and bone structures by MRI","text_display":"\n- To explore the treatment effect on the knee joint and bone structures by MRI","confidence":1,"confidence_rate":1},{"cnt":[[245,1629],[965,1629],[965,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1628,"width":721,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"265a4052778648489d36db2366395a3a","type":"text","conversion_output":true,"text":"- To evaluate long-term treatment effects","text_display":"\n- To evaluate long-term treatment effects","confidence":1,"confidence_rate":1},{"cnt":[[245,1697],[1880,1697],[1880,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1697,"width":1636,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81ee90194a1640acb481ad05f88b6316","type":"text","conversion_output":true,"text":"- To explore the relationship between the change over time in synovial, serum and urine","text_display":"\n- To explore the relationship between the change over time in synovial, serum and urine","confidence":1,"confidence_rate":1},{"cnt":[[294,1747],[1882,1747],[1882,1798],[294,1798]],"region":{"top_left_x":294,"top_left_y":1746,"width":1589,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2f147e35a6847808be48652232e1525","type":"text","conversion_output":true,"text":"biomarkers (e.g., cartilage and bone tissue turnover markers, inflammation markers) and the","text_display":" biomarkers (e.g., cartilage and bone tissue turnover markers, inflammation markers) and the","confidence":1,"confidence_rate":1},{"cnt":[[292,1796],[642,1796],[642,1850],[292,1850]],"region":{"top_left_x":292,"top_left_y":1796,"width":351,"height":54},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"464a121806884b359c1be48927319047","type":"text","conversion_output":true,"text":"response to the drug","text_display":" response to the drug","confidence":1,"confidence_rate":1},{"cnt":[[245,1867],[1880,1867],[1880,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1866,"width":1636,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e7e3bfcf6c44405a967483f1bda9ef2","type":"text","conversion_output":true,"text":"- To evaluate potential associations of biomarkers (e.g., genetic variations or protein","text_display":"\n- To evaluate potential associations of biomarkers (e.g., genetic variations or protein","confidence":1,"confidence_rate":1},{"cnt":[[292,1914],[1880,1914],[1880,1966],[292,1966]],"region":{"top_left_x":292,"top_left_y":1914,"width":1588,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f12301d4d8f6441394b53a8e79fd665e","type":"text","conversion_output":true,"text":"biomarkers measured at baseline) with drug response and/or disease severity or disease","text_display":" biomarkers measured at baseline) with drug response and/or disease severity or disease","confidence":1,"confidence_rate":1},{"cnt":[[292,1962],[501,1962],[501,2017],[292,2017]],"region":{"top_left_x":292,"top_left_y":1961,"width":209,"height":57},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a27b59b420b14148ade13e9bb6bb8451","type":"text","conversion_output":true,"text":"progression","text_display":" progression","confidence":1,"confidence_rate":1},{"cnt":[[245,2032],[1882,2032],[1882,2086],[245,2086]],"region":{"top_left_x":244,"top_left_y":2032,"width":1639,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ad65c0adf3b493fb46d3cd1b3f3a322","type":"text","conversion_output":true,"text":"- To explore the relationship between dosing (dose and regimen), cartilage structure, and","text_display":"\n- To explore the relationship between dosing (dose and regimen), cartilage structure, and","confidence":1,"confidence_rate":1},{"cnt":[[292,2082],[1291,2082],[1291,2136],[292,2136]],"region":{"top_left_x":292,"top_left_y":2081,"width":1000,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b8ae01b11574cbab387fe746d4bed73","type":"text","conversion_output":true,"text":"clinical scores as a function of time, by means of modeling","text_display":" clinical scores as a function of time, by means of modeling","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":36,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fe6938a93fbc4e959713769abd3728d6","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":37,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d1746c8006254d3db61431872c2e49d1","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a6ed9c7426248a187d629aaddfa6dd9","type":"page_info","conversion_output":false,"text":"30/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-031","page":31,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d5c04fcd4b44cc6957070d4e06230f5","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"500d175d92a84c598ffce2d1b4ecb71b","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db2dfce97cfb462da940074423bd1781","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[1025,275],[1025,346],[241,346]],"region":{"top_left_x":240,"top_left_y":275,"width":785,"height":71},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0730b45dafc442f2bcd5deb3f52b8102","type":"section_header","conversion_output":false,"children_ids":["d8e8dcd5c154445f96b12d1400068975","0dd36058e80b4ef98ecacde24a119440"],"text":"","text_display":""},{"cnt":[[243,277],[284,277],[284,335],[243,335]],"region":{"top_left_x":242,"top_left_y":277,"width":42,"height":59},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8e8dcd5c154445f96b12d1400068975","type":"text","conversion_output":true,"parent_id":"0730b45dafc442f2bcd5deb3f52b8102","text":"5","text_display":"\n\n\\section*{5","confidence":0.99951171875,"confidence_rate":0.99951171875},{"cnt":[[593,284],[1021,284],[1021,342],[593,342]],"region":{"top_left_x":592,"top_left_y":283,"width":429,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dd36058e80b4ef98ecacde24a119440","type":"text","conversion_output":true,"parent_id":"0730b45dafc442f2bcd5deb3f52b8102","text":"Investigational Plan","text_display":" Investigational Plan}","confidence":1,"confidence_rate":1},{"cnt":[[236,374],[1240,374],[1240,449],[236,449]],"region":{"top_left_x":236,"top_left_y":373,"width":1004,"height":77},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e627f5c793b4150aca026b8d2351a0b","type":"section_header","conversion_output":false,"children_ids":["b5001d190a2f439b9a78a0d0bd61382c"],"text":"","text_display":""},{"cnt":[[243,380],[1233,380],[1233,447],[243,447]],"region":{"top_left_x":242,"top_left_y":380,"width":992,"height":67},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5001d190a2f439b9a78a0d0bd61382c","type":"text","conversion_output":true,"parent_id":"5e627f5c793b4150aca026b8d2351a0b","text":"5.1 Overall Trial Design and Plan","text_display":"\n\n\\subsection*{5.1 Overall Trial Design and Plan}","confidence":0.9604682922363281,"confidence_rate":0.9989104775004164},{"cnt":[[245,475],[1882,475],[1882,526],[245,526]],"region":{"top_left_x":244,"top_left_y":474,"width":1639,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30df999f7c764a32952f67d4d065fd6b","type":"text","conversion_output":true,"text":"This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase II trial","text_display":"\n\nThis is a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase II trial","confidence":1,"confidence_rate":1},{"cnt":[[245,524],[1884,524],[1884,574],[245,574]],"region":{"top_left_x":244,"top_left_y":524,"width":1641,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ce4f00381b84d6fadeefb9a637828bf","type":"text","conversion_output":true,"text":"of sprifermin administered i.a. in subjects with primary OA of the knee and Kellgren-Lawrence","text_display":" of sprifermin administered i.a. in subjects with primary OA of the knee and Kellgren-Lawrence","confidence":0.99853515625,"confidence_rate":0.9999850417681765},{"cnt":[[245,571],[466,571],[466,623],[245,623]],"region":{"top_left_x":244,"top_left_y":571,"width":223,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33cca67c88244a60966e2abce61fff0e","type":"text","conversion_output":true,"text":"grade 2 or 3.","text_display":" grade 2 or 3.","confidence":0.96923828125,"confidence_rate":0.9984389800092426},{"cnt":[[245,662],[1884,662],[1884,713],[245,713]],"region":{"top_left_x":244,"top_left_y":661,"width":1641,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57c1c5a481ed4f6e87821698d11c028f","type":"text","conversion_output":true,"text":"The trial will randomize approximately 545 subjects ( 109 per treatment group); sample size","text_display":"\n\nThe trial will randomize approximately 545 subjects ( 109 per treatment group); sample size","confidence":0.9858860643580556,"confidence_rate":0.9998606520191877},{"cnt":[[245,709],[939,709],[939,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":695,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d959978ffc64d5582543872dcb63ff3","type":"text","conversion_output":true,"text":"calculations are described in Section 8.1.","text_display":" calculations are described in Section 8.1.","confidence":1,"confidence_rate":1},{"cnt":[[245,797],[1884,797],[1884,849],[245,849]],"region":{"top_left_x":244,"top_left_y":797,"width":1641,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4868f3bf30c64e829a66d961a0427366","type":"text","conversion_output":true,"text":"The trial consists of a screening period lasting up to 42 days, a 2-year (104-week) double-blind","text_display":"\n\nThe trial consists of a screening period lasting up to 42 days, a 2-year (104-week) double-blind","confidence":0.45299291610717773,"confidence_rate":0.9924146955847355},{"cnt":[[245,846],[1882,846],[1882,900],[245,900]],"region":{"top_left_x":244,"top_left_y":846,"width":1639,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed8085694b704b0aa6c8bd50dd8e547d","type":"text","conversion_output":true,"text":"placebo-controlled (DBPC) treatment phase, which will start at randomization (Week 0/Visit 2),","text_display":" placebo-controlled (DBPC) treatment phase, which will start at randomization (Week 0/Visit 2),","confidence":0.99853515625,"confidence_rate":0.9999851928603086},{"cnt":[[245,894],[1377,894],[1377,947],[245,947]],"region":{"top_left_x":244,"top_left_y":893,"width":1134,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02e7fa5b09b9460e95ee8013631b17e8","type":"text","conversion_output":true,"text":"and a 3-year extended follow-up phase (see Figure 1 and Figure 2).","text_display":" and a 3-year extended follow-up phase (see Figure 1 and Figure 2).","confidence":0.99853515625,"confidence_rate":0.9999801904977986},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd7f9df10285489e98c8c81b233a7523","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2527],[1605,2527],[1605,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2526,"width":97,"height":38},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0d7aa46d245440c9056685cdbc1c984","type":"page_info","conversion_output":false,"text":"31/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[391,2546],[391,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":148,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aee738b5c0664763abe1adb8653439fe","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-032","page":32,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3a52372a9a84e2487a3a8c9affd6fe8","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,127],[1317,127],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":126,"width":673,"height":49},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"317d1c7bc810459192d3d2c883d7d00b","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d46f02de375948d5b2722dee960fcf67","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,284],[402,284],[402,333],[245,333]],"region":{"top_left_x":244,"top_left_y":283,"width":158,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a7a4df94e834bcfa5b7f1a3e5f0d191","type":"figure_label","conversion_output":false,"text":"Figure 1","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[593,281],[1577,281],[1577,333],[593,333]],"region":{"top_left_x":592,"top_left_y":281,"width":985,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"926078921a1c4aebb7d5e74aa6bf287d","type":"figure_label","conversion_output":true,"text":"Trial Schema: Screening and DBPC Treatment Phases","text_display":"\n\nTrial Schema: Screening and DBPC Treatment Phases","confidence":1,"confidence_rate":1},{"cnt":[[245,367],[1886,367],[1886,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":367,"width":1643,"height":1286},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25708efa48d34b868b796060c5e2cc1e","type":"diagram","conversion_output":true,"selected_labels":["0a7a4df94e834bcfa5b7f1a3e5f0d191","926078921a1c4aebb7d5e74aa6bf287d"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 1}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-032.jpg?height=1286&width=1643&top_left_y=367&top_left_x=244}\n\\end{figure}"},{"cnt":[[245,1650],[1846,1650],[1846,1691],[245,1691]],"region":{"top_left_x":244,"top_left_y":1649,"width":1602,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12aa3a8f949249e18f1baa482d6053fd","type":"text","conversion_output":true,"text":"Abbreviations: W: Week; MRI: magnetic resonance imaging; WOMAC: Western Ontario and McMaster Universities","text_display":"\n\nAbbreviations: W: Week; MRI: magnetic resonance imaging; WOMAC: Western Ontario and McMaster Universities","confidence":1,"confidence_rate":1},{"cnt":[[245,1684],[1863,1684],[1863,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1684,"width":1619,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fe85492d9c44fe79a524151e3e7ea17","type":"text","conversion_output":true,"text":"Osteoarthritis Index; PGA: Patient's Global Assessment; KOOS QOL: Knee Injury and Osteoarthritis Outcome Score","text_display":" Osteoarthritis Index; PGA: Patient's Global Assessment; KOOS QOL: Knee Injury and Osteoarthritis Outcome Score","confidence":1,"confidence_rate":1},{"cnt":[[245,1721],[1772,1721],[1772,1764],[245,1764]],"region":{"top_left_x":244,"top_left_y":1720,"width":1529,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6096155167de452cb04da53440adfbcb","type":"text","conversion_output":true,"text":"quality of life subscale; KOOS Symptom Index: Knee Injury and Osteoarthritis Outcome Score symptom index","text_display":" quality of life subscale; KOOS Symptom Index: Knee Injury and Osteoarthritis Outcome Score symptom index","confidence":1,"confidence_rate":1},{"cnt":[[245,1757],[1824,1757],[1824,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1757,"width":1581,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35999696c2cf4697b5d68039bfb34eb1","type":"text","conversion_output":true,"text":"subscale; PGIC: Patient's Global Impression of Change; NRS pain score: numerical rating scale pain score; MOS","text_display":" subscale; PGIC: Patient's Global Impression of Change; NRS pain score: numerical rating scale pain score; MOS","confidence":0.98876953125,"confidence_rate":0.9999009346737956},{"cnt":[[245,1792],[1755,1792],[1755,1833],[245,1833]],"region":{"top_left_x":244,"top_left_y":1791,"width":1512,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4212d754ca44bd4918df4a1aac9ce06","type":"text","conversion_output":true,"text":"SF-36: Medical Outcomes Study Short Form-36 General Health Survey; ICOAP: Measure of Intermittent and","text_display":" SF-36: Medical Outcomes Study Short Form-36 General Health Survey; ICOAP: Measure of Intermittent and","confidence":1,"confidence_rate":1},{"cnt":[[245,1828],[655,1828],[655,1867],[245,1867]],"region":{"top_left_x":244,"top_left_y":1828,"width":412,"height":39},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2aed2f0562b74a1f8480f279f6ac3dfd","type":"text","conversion_output":true,"text":"Constant Osteoarthritis Pain.","text_display":" Constant Osteoarthritis Pain.","confidence":1,"confidence_rate":1},{"cnt":[[245,1869],[1422,1869],[1422,1914],[245,1914]],"region":{"top_left_x":244,"top_left_y":1869,"width":1179,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49f94b150aea42a8ab60e3aeeb0156ea","type":"text","conversion_output":true,"text":"Each treatment cycle consists of one i.a. injection per week for 3 consecutive weeks.","text_display":"\nEach treatment cycle consists of one i.a. injection per week for 3 consecutive weeks.","confidence":0.9423828125,"confidence_rate":0.9993620991983954},{"cnt":[[245,1912],[1863,1912],[1863,1955],[245,1955]],"region":{"top_left_x":244,"top_left_y":1912,"width":1619,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2f4f3294aea46729e77497abd329e5f","type":"text","conversion_output":true,"text":"DBPC treatment phase visits will occur at Weeks 0 (randomization and first IMP injection), \\(1,2,3,12,26,27,28,29\\),","text_display":"\nDBPC treatment phase visits will occur at Weeks 0 (randomization and first IMP injection), \\(1,2,3,12,26,27,28,29\\),","confidence":0.94562874594385,"confidence_rate":0.9995492529629055},{"cnt":[[245,1951],[950,1951],[950,1992],[245,1992]],"region":{"top_left_x":244,"top_left_y":1950,"width":706,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"873805b1431449748a3087a3006668dd","type":"text","conversion_output":true,"text":"\\(38,52,53,54,55,64,78,79,80,81,90\\) and 104.","text_display":" \\(38,52,53,54,55,64,78,79,80,81,90\\) and 104.","confidence":0.87060546875,"confidence_rate":0.9968557179980456},{"cnt":[[245,1989],[1751,1989],[1751,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1989,"width":1507,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"281677faffd74c8296d00b6c85943643","type":"text","conversion_output":true,"text":"Pain medications must be withheld for at least 5 half-lives before a visit involving completion of the WOMAC.","text_display":"\nPain medications must be withheld for at least 5 half-lives before a visit involving completion of the WOMAC.","confidence":0.99951171875,"confidence_rate":0.999995825645481},{"cnt":[[245,2032],[1846,2032],[1846,2078],[245,2078]],"region":{"top_left_x":244,"top_left_y":2032,"width":1602,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5da9c5a740464946b0814f5d9eb2fcd3","type":"text","conversion_output":true,"text":"Adverse events, concomitant medications, and concomitant procedures (including concomitant surgical procedures","text_display":" Adverse events, concomitant medications, and concomitant procedures (including concomitant surgical procedures","confidence":1,"confidence_rate":1},{"cnt":[[245,2071],[1781,2071],[1781,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2071,"width":1538,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eebb79f8f9794c01b60ae68425235eca","type":"text","conversion_output":true,"text":"on the target knee) will be monitored throughout the trial. Time points for safety, laboratory, PK, and biomarker","text_display":" on the target knee) will be monitored throughout the trial. Time points for safety, laboratory, PK, and biomarker","confidence":1,"confidence_rate":1},{"cnt":[[245,2110],[799,2110],[799,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2109,"width":556,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"522e8bbb71414aa4bcbe7f4cd6cb8d7a","type":"text","conversion_output":true,"text":"assessments are shown in Appendix E.","text_display":" assessments are shown in Appendix E.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b6263c2077d4613a20fdaf4469503e9","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":40},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4da1a04817b74eb7b850a9a2094f12f1","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6aee272175fd489798375e4186c708a6","type":"page_info","conversion_output":false,"text":"32/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2608],[1796,2608]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":109},"line":23,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"01995e31a8864bd790e5f76e8825eb04","type":"page_info","conversion_output":false,"text":"","text_display":""}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-033","page":33,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a4d0afac1e045f1b291c684812d7f03","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e7e9846005b443da88ce9c670bb85fc","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e037a151786e48cd8d95e1e7b9c50278","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1343,279],[1343,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1099,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"375ed428b95b427d97c639a53933fb2c","type":"figure_label","conversion_output":false,"text":"Figure 2 Trial Schema: Extended Follow-up Phase","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999911200303706},{"cnt":[[245,365],[1824,365],[1824,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":365,"width":1581,"height":905},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"043a4ee1f1404f74aec7d8b7cb5f4f7d","type":"diagram","conversion_output":true,"selected_labels":["375ed428b95b427d97c639a53933fb2c"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 2 Trial Schema: Extended Follow-up Phase}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-033.jpg?height=905&width=1581&top_left_y=365&top_left_x=244}\n\\end{figure}"},{"cnt":[[473,1283],[526,1283],[526,1334],[473,1334]],"region":{"top_left_x":472,"top_left_y":1282,"width":55,"height":53},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4e8f3fffc054100be3ed508730b85da","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-033.jpg?height=53&width=55&top_left_y=1282&top_left_x=472)"},{"cnt":[[526,1293],[1846,1293],[1846,1334],[526,1334]],"region":{"top_left_x":526,"top_left_y":1293,"width":1320,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4b1620ead4d44bcbbcff9de7522592e","type":"text","conversion_output":true,"text":"MRI, X-ray, WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain score,","text_display":"\n\nMRI, X-ray, WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain score,","confidence":1,"confidence_rate":1},{"cnt":[[526,1332],[1414,1332],[1414,1373],[526,1373]],"region":{"top_left_x":526,"top_left_y":1332,"width":888,"height":41},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"888efa5453f04105a7ab74186f78d32d","type":"text","conversion_output":true,"text":"pain in other joints, MOS SF-36, ICOAP, 20-meter walk test","text_display":" pain in other joints, MOS SF-36, ICOAP, 20-meter walk test","confidence":0.71875,"confidence_rate":0.9947717834107563},{"cnt":[[473,1366],[524,1366],[524,1414],[473,1414]],"region":{"top_left_x":472,"top_left_y":1366,"width":53,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2ad5dfafd61429895a96badedba2c1e","type":"text","conversion_output":true,"text":"△","text_display":"\n△","confidence":0.8112335205078125,"confidence_rate":0.9657342808953324},{"cnt":[[524,1371],[1863,1371],[1863,1412],[524,1412]],"region":{"top_left_x":524,"top_left_y":1370,"width":1339,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6cca15b21af4b9baa0cb8d4ad7ac08c","type":"text","conversion_output":true,"text":"WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain score, pain in other","text_display":" WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain score, pain in other","confidence":1,"confidence_rate":1},{"cnt":[[524,1409],[1231,1409],[1231,1450],[524,1450]],"region":{"top_left_x":524,"top_left_y":1409,"width":708,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8f6972d7d3f4bc4882964088c8a829d","type":"text","conversion_output":true,"text":"joints, MOS SF-36, ICOAP, 20-meter walk test.","text_display":" joints, MOS SF-36, ICOAP, 20-meter walk test.","confidence":0.99951171875,"confidence_rate":0.9999902320377446},{"cnt":[[524,1450],[1055,1450],[1055,1493],[524,1493]],"region":{"top_left_x":524,"top_left_y":1450,"width":531,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3900064a224143298c0051dba793e236","type":"text","conversion_output":true,"text":"Safety will be assessed at all visits.","text_display":"\nSafety will be assessed at all visits.","confidence":1,"confidence_rate":1},{"cnt":[[251,1497],[1710,1497],[1710,1536],[251,1536]],"region":{"top_left_x":251,"top_left_y":1497,"width":1460,"height":40},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01dcd80d5f8e44a49b8fbf445e9780c2","type":"text","conversion_output":true,"text":"Abbreviations: W: Week; EF: Extended Follow-up; WOMAC: Western Ontario and McMaster Universities","text_display":"\nAbbreviations: W: Week; EF: Extended Follow-up; WOMAC: Western Ontario and McMaster Universities","confidence":0.99853515625,"confidence_rate":0.9999854860688677},{"cnt":[[245,1534],[1863,1534],[1863,1573],[245,1573]],"region":{"top_left_x":244,"top_left_y":1533,"width":1619,"height":40},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"741fe376bd45499abe4772eed3cccad5","type":"text","conversion_output":true,"text":"Osteoarthritis Index; PGA: Patient's Global Assessment; KOOS QOL: Knee Injury and Osteoarthritis Outcome Score","text_display":" Osteoarthritis Index; PGA: Patient's Global Assessment; KOOS QOL: Knee Injury and Osteoarthritis Outcome Score","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,1568],[1772,1568],[1772,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1568,"width":1529,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8b4a74961694ef59a1d52a40bad823a","type":"text","conversion_output":true,"text":"quality of life subscale; KOOS Symptom Index: Knee Injury and Osteoarthritis Outcome Score symptom index","text_display":" quality of life subscale; KOOS Symptom Index: Knee Injury and Osteoarthritis Outcome Score symptom index","confidence":1,"confidence_rate":1},{"cnt":[[245,1607],[1824,1607],[1824,1646],[245,1646]],"region":{"top_left_x":244,"top_left_y":1607,"width":1581,"height":39},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f26733f1c134cc2adfb0fa3f65ecb92","type":"text","conversion_output":true,"text":"subscale; PGIC: Patient's Global Impression of Change; NRS pain score: numerical rating scale pain score; MOS","text_display":" subscale; PGIC: Patient's Global Impression of Change; NRS pain score: numerical rating scale pain score; MOS","confidence":0.986328125,"confidence_rate":0.9998792511875305},{"cnt":[[245,1641],[1755,1641],[1755,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1641,"width":1512,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2afa64ff11c432f98b2382c95004610","type":"text","conversion_output":true,"text":"SF-36: Medical Outcomes Study Short Form-36 General Health Survey; ICOAP: Measure of Intermittent and","text_display":" SF-36: Medical Outcomes Study Short Form-36 General Health Survey; ICOAP: Measure of Intermittent and","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,1676],[1145,1676],[1145,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1675,"width":902,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75e71af7abf24b2090b68f6bea0238ad","type":"text","conversion_output":true,"text":"Constant Osteoarthritis Pain; MRI: magnetic resonance imaging.","text_display":" Constant Osteoarthritis Pain; MRI: magnetic resonance imaging.","confidence":1,"confidence_rate":1},{"cnt":[[245,1719],[1751,1719],[1751,1760],[245,1760]],"region":{"top_left_x":244,"top_left_y":1718,"width":1507,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66dd521708454ea29bdb01165c0226f7","type":"text","conversion_output":true,"text":"Pain medications must be withheld for at least 5 half-lives before a visit involving completion of the WOMAC.","text_display":"\nPain medications must be withheld for at least 5 half-lives before a visit involving completion of the WOMAC.","confidence":0.9990234375,"confidence_rate":0.9999916492686468},{"cnt":[[245,1762],[1846,1762],[1846,1803],[245,1803]],"region":{"top_left_x":244,"top_left_y":1761,"width":1602,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84703a5323b44845aef58cb00bf6c3e8","type":"text","conversion_output":true,"text":"Adverse events, concomitant medications, and concomitant procedures (including concomitant surgical procedures","text_display":" Adverse events, concomitant medications, and concomitant procedures (including concomitant surgical procedures","confidence":1,"confidence_rate":1},{"cnt":[[245,1800],[1841,1800],[1841,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1800,"width":1598,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"496dea874b934f769c48d4d3f15e2bdb","type":"text","conversion_output":true,"text":"on the target knee) will be monitored throughout the trial. Safety assessments during the extended follow-up phase","text_display":" on the target knee) will be monitored throughout the trial. Safety assessments during the extended follow-up phase","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[608,1835],[608,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1834,"width":365,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfe1f729d68c49209e795674fa69d258","type":"text","conversion_output":true,"text":"are shown in Appendix E.","text_display":" are shown in Appendix E.","confidence":1,"confidence_rate":1},{"cnt":[[243,1912],[561,1912],[561,1970],[243,1970]],"region":{"top_left_x":242,"top_left_y":1912,"width":319,"height":59},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6adf30b1e434bdebd36a466abae8997","type":"section_header","conversion_output":false,"children_ids":["46542589fefd460ababbe2f951fb74eb"],"text":"","text_display":""},{"cnt":[[245,1916],[556,1916],[556,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1916,"width":313,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46542589fefd460ababbe2f951fb74eb","type":"text","conversion_output":true,"parent_id":"a6adf30b1e434bdebd36a466abae8997","text":"Screening Period","text_display":"\n\n\\section*{Screening Period}","confidence":1,"confidence_rate":1},{"cnt":[[245,2004],[1882,2004],[1882,2054],[245,2054]],"region":{"top_left_x":244,"top_left_y":2004,"width":1639,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4661bb647d974536b145970f9a0db5dc","type":"text","conversion_output":true,"text":"The screening period will comprise a period of 4 to 42 days during which a subject's eligibility","text_display":"\n\nThe screening period will comprise a period of 4 to 42 days during which a subject's eligibility","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,2052],[1880,2052],[1880,2101],[245,2101]],"region":{"top_left_x":244,"top_left_y":2051,"width":1636,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53593d1d47d94fc7ba55948e1d4e554e","type":"text","conversion_output":true,"text":"for the trial will be determined, beginning at signature of the informed consent form (ICF)","text_display":" for the trial will be determined, beginning at signature of the informed consent form (ICF)","confidence":1,"confidence_rate":1},{"cnt":[[245,2099],[1880,2099],[1880,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2099,"width":1636,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bc894c5ec3e4e7bb15bce55d30af658","type":"text","conversion_output":true,"text":"(Visit 1a). Subjects who have taken analgesia within 5 half-lives of the visit will be scheduled to","text_display":" (Visit 1a). Subjects who have taken analgesia within 5 half-lives of the visit will be scheduled to","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,2148],[1880,2148],[1880,2198],[245,2198]],"region":{"top_left_x":244,"top_left_y":2148,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd11adfa1a89411d91f8002df8c3fbe6","type":"text","conversion_output":true,"text":"return for complete screening procedures (Visit 1b) after a washout of all analgesic medications.","text_display":" return for complete screening procedures (Visit 1b) after a washout of all analgesic medications.","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1880,2196],[1880,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2195,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bea0083d0a9b456484227ffb56be13fe","type":"text","conversion_output":true,"text":"Subjects not taking analgesic medication at the time of ICF signature may complete Visit 1a and","text_display":" Subjects not taking analgesic medication at the time of ICF signature may complete Visit 1a and","confidence":1,"confidence_rate":1},{"cnt":[[247,2243],[1880,2243],[1880,2292],[247,2292]],"region":{"top_left_x":247,"top_left_y":2242,"width":1633,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef0495c821cb4944b1b0377ff1ef8c69","type":"text","conversion_output":true,"text":"1b procedures at one visit. Screening will include completion of Question 1 of the WOMAC pain","text_display":" 1b procedures at one visit. Screening will include completion of Question 1 of the WOMAC pain","confidence":0.99658203125,"confidence_rate":0.9999661013334881},{"cnt":[[245,2290],[1880,2290],[1880,2342],[245,2342]],"region":{"top_left_x":244,"top_left_y":2290,"width":1636,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d832605f42a94c33939a7488b963d5f1","type":"text","conversion_output":true,"text":"index and pain on an 11-point pain numerical rating scale (NRS) in both the target and","text_display":" index and pain on an 11-point pain numerical rating scale (NRS) in both the target and","confidence":1,"confidence_rate":1},{"cnt":[[245,2340],[1880,2340],[1880,2391],[245,2391]],"region":{"top_left_x":244,"top_left_y":2339,"width":1636,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c60fbb763b0d45a3886d7ca3bcabfcd3","type":"text","conversion_output":true,"text":"contralateral knee. Subjects who have a WOMAC Question 1 score in the target knee of 4 to 9","text_display":" contralateral knee. Subjects who have a WOMAC Question 1 score in the target knee of 4 to 9","confidence":1,"confidence_rate":1},{"cnt":[[245,2389],[1880,2389],[1880,2438],[245,2438]],"region":{"top_left_x":244,"top_left_y":2389,"width":1636,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"219af150af5e4d2998abbeb87f5d673e","type":"text","conversion_output":true,"text":"after a predefined analgesic washout period equivalent to at least 5 half-lives of the analgesic","text_display":" after a predefined analgesic washout period equivalent to at least 5 half-lives of the analgesic","confidence":1,"confidence_rate":1},{"cnt":[[245,2436],[1880,2436],[1880,2486],[245,2486]],"region":{"top_left_x":244,"top_left_y":2436,"width":1636,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50a3a1da85d341ebacfd5623752cd078","type":"text","conversion_output":true,"text":"medication(s) will continue with other screening procedures. During the screening period,","text_display":" medication(s) will continue with other screening procedures. During the screening period,","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65d925129e414ae0a687c7f8dd35b9c7","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a67d8f0db9f641c0b690ad642925836a","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc7e9daaaab74022889c4f1207f3fe0e","type":"page_info","conversion_output":false,"text":"33/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1794,2501],[1904,2501],[1904,2608],[1794,2608]],"region":{"top_left_x":1793,"top_left_y":2500,"width":111,"height":109},"line":38,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"1ef724b6a4554ee5ade93c467b812ddb","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-033.jpg?height=109&width=111&top_left_y=2500&top_left_x=1793)"}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-034","page":34,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28a17d71995b46f596269b30f5b822fb","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b348356691634c309815bc6c5777b517","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6c4658f7e974cd287690759750175bb","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0211a3fd74a04132845817d6af568d2d","type":"text","conversion_output":true,"text":"demographic and medical history data will be collected and subjects will undergo physical","text_display":"\ndemographic and medical history data will be collected and subjects will undergo physical","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1880,329],[1880,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1636,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eddadb8c002a445990304644a01a8119","type":"text","conversion_output":true,"text":"examination including height and weight and safety laboratory assessment (hematology,","text_display":" examination including height and weight and safety laboratory assessment (hematology,","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1880,374],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cfe6db7c053421d9cb600afdc474322","type":"text","conversion_output":true,"text":"biochemistry, and urinalysis). X-rays will be taken of both knees, and the target knee will be","text_display":" biochemistry, and urinalysis). X-rays will be taken of both knees, and the target knee will be","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[423,425],[423,471],[245,471]],"region":{"top_left_x":244,"top_left_y":425,"width":180,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c8c4879d73c4037896aafe0e0133d1f","type":"text","conversion_output":true,"text":"identified.","text_display":" identified.","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1880,511],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":511,"width":1636,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"467cbd1be258468693b795774001cc16","type":"text","conversion_output":true,"text":"If subjects fulfill all inclusion and no exclusion criteria (see Sections 5.3.1, 5.3.2, and 5.4), they","text_display":"\n\nIf subjects fulfill all inclusion and no exclusion criteria (see Sections 5.3.1, 5.3.2, and 5.4), they","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,563],[799,563],[799,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":556,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2da3e8690dc5438c9eff862350d8028f","type":"text","conversion_output":true,"text":"will be randomized into the trial.","text_display":" will be randomized into the trial.","confidence":1,"confidence_rate":1},{"cnt":[[236,645],[690,645],[690,703],[236,703]],"region":{"top_left_x":236,"top_left_y":644,"width":454,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a9c83de3ed34733be436e067ef9096a","type":"section_header","conversion_output":false,"children_ids":["91c8c52c981c49fd846092b045c8a620"],"text":"","text_display":""},{"cnt":[[245,653],[683,653],[683,698],[245,698]],"region":{"top_left_x":244,"top_left_y":653,"width":440,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91c8c52c981c49fd846092b045c8a620","type":"text","conversion_output":true,"parent_id":"1a9c83de3ed34733be436e067ef9096a","text":"DBPC Treatment Phase","text_display":"\n\n\\section*{DBPC Treatment Phase}","confidence":1,"confidence_rate":1},{"cnt":[[245,741],[1880,741],[1880,793],[245,793]],"region":{"top_left_x":244,"top_left_y":741,"width":1636,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f46f5db699b4bfeb097e78ce44c4d0f","type":"text","conversion_output":true,"text":"In the DBPC treatment phase, all subjects will receive 4 cycles of treatment with the IMP","text_display":"\n\nIn the DBPC treatment phase, all subjects will receive 4 cycles of treatment with the IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[1880,786],[1880,840],[245,840]],"region":{"top_left_x":244,"top_left_y":786,"width":1636,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d40b20db3193422ea1f8bdfa5802adba","type":"text","conversion_output":true,"text":"(sprifermin or matching placebo) at intervals of 6 months. Each cycle will consist of 3 once-","text_display":" (sprifermin or matching placebo) at intervals of 6 months. Each cycle will consist of 3 once","confidence":0.9907309989212081,"confidence_rate":0.9999104633781115},{"cnt":[[245,836],[1246,836],[1246,887],[245,887]],"region":{"top_left_x":244,"top_left_y":835,"width":1003,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ff963600ba646859dfacc195529c9aa","type":"text","conversion_output":true,"text":"weekly i.a. injections over a period of 3 consecutive weeks.","text_display":"weekly i.a. injections over a period of 3 consecutive weeks.","confidence":0.9790768623352051,"confidence_rate":0.9996890905708005},{"cnt":[[245,924],[1880,924],[1880,978],[245,978]],"region":{"top_left_x":244,"top_left_y":923,"width":1636,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffdf2701f2d84e8abe17ce5d2ffd8bea","type":"text","conversion_output":true,"text":"The DBPC treatment phase will begin at the baseline visit (Week 0/Visit 2), when eligibility will","text_display":"\n\nThe DBPC treatment phase will begin at the baseline visit (Week 0/Visit 2), when eligibility will","confidence":1,"confidence_rate":1},{"cnt":[[245,973],[1783,973],[1783,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":973,"width":1540,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"270608c361c04e4faf57483e6e358cdc","type":"text","conversion_output":true,"text":"be confirmed, subjects will be randomized, and the first IMP injection will be administered.","text_display":" be confirmed, subjects will be randomized, and the first IMP injection will be administered.","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1880,1061],[1880,1115],[245,1115]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7a126c916db45a9a335300a0bf12fa7","type":"text","conversion_output":true,"text":"Subjects will be randomized in equal allocation to one of the following treatment groups, as","text_display":"\n\nSubjects will be randomized in equal allocation to one of the following treatment groups, as","confidence":1,"confidence_rate":1},{"cnt":[[245,1111],[1296,1111],[1296,1162],[245,1162]],"region":{"top_left_x":244,"top_left_y":1110,"width":1052,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27b5c00608894105b9d191252ba60cbc","type":"text","conversion_output":true,"text":"shown in Figure 1 (randomization is described in Section 6.3).","text_display":" shown in Figure 1 (randomization is described in Section 6.3).","confidence":1,"confidence_rate":1},{"cnt":[[245,1182],[1072,1182],[1072,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1181,"width":829,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45f09a6b4a2a4f38b15bd69ae23aab7f","type":"text","conversion_output":true,"text":"- 4 cycles of sprifermin ( 100 mcg per injection)","text_display":"\n- 4 cycles of sprifermin ( 100 mcg per injection)","confidence":0.9960973262786865,"confidence_rate":0.9999348303065655},{"cnt":[[245,1255],[1676,1255],[1676,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1254,"width":1432,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ff2be21f933499083c2914b3ff4ae75","type":"text","conversion_output":true,"text":"- 2 cycles of sprifermin ( 100 mcg per injection) alternating with 2 cycles of placebo","text_display":"\n- 2 cycles of sprifermin ( 100 mcg per injection) alternating with 2 cycles of placebo","confidence":0.9795200824737549,"confidence_rate":0.9997971525466512},{"cnt":[[245,1328],[1051,1328],[1051,1379],[245,1379]],"region":{"top_left_x":244,"top_left_y":1327,"width":807,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a332fcbf6a83402890933fda4f6fed5b","type":"text","conversion_output":true,"text":"- 4 cycles of sprifermin ( 30 mcg per injection)","text_display":"\n- 4 cycles of sprifermin ( 30 mcg per injection)","confidence":0.8532161260955036,"confidence_rate":0.9974010488440702},{"cnt":[[245,1396],[1654,1396],[1654,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1396,"width":1411,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b213324822cc4e8196a53939734fc6b5","type":"text","conversion_output":true,"text":"- 2 cycles of sprifermin ( 30 mcg per injection) alternating with 2 cycles of placebo","text_display":"\n- 2 cycles of sprifermin ( 30 mcg per injection) alternating with 2 cycles of placebo","confidence":0.8586426787333039,"confidence_rate":0.9984922030472385},{"cnt":[[245,1470],[625,1470],[625,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1469,"width":382,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f27ff09427b44e98ae493529c9d49132","type":"text","conversion_output":true,"text":"- 4 cycles of placebo","text_display":"\n- 4 cycles of placebo","confidence":1,"confidence_rate":1},{"cnt":[[245,1560],[1882,1560],[1882,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1559,"width":1639,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b32e90bea040467cbe5a936b39300f35","type":"text","conversion_output":true,"text":"The last of the four cycles of 3 injections of IMP will be given on Week 78/Visit 17, and the last","text_display":"\n\nThe last of the four cycles of 3 injections of IMP will be given on Week 78/Visit 17, and the last","confidence":0.998535871389322,"confidence_rate":0.9999861774399256},{"cnt":[[245,1607],[1882,1607],[1882,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1607,"width":1639,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb8647665b6b45d9bdc9d0d1ab92ca85","type":"text","conversion_output":true,"text":"dose of IMP is scheduled to be administered at Week 80/Visit 19. IMP administration for each","text_display":" dose of IMP is scheduled to be administered at Week 80/Visit 19. IMP administration for each","confidence":1,"confidence_rate":1},{"cnt":[[245,1654],[1171,1654],[1171,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1654,"width":927,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26498aff870f4bea91254aff8772d7f6","type":"text","conversion_output":true,"text":"treatment group is summarized in Table 1, Section 6.2.","text_display":" treatment group is summarized in Table 1, Section 6.2.","confidence":1,"confidence_rate":1},{"cnt":[[245,1745],[1880,1745],[1880,1796],[245,1796]],"region":{"top_left_x":244,"top_left_y":1744,"width":1636,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35c8970e8eb9412197012606aab0e033","type":"text","conversion_output":true,"text":"Major efficacy assessments will take place at intervals of 6 months, on the first day of each","text_display":"\n\nMajor efficacy assessments will take place at intervals of 6 months, on the first day of each","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[245,1792],[1613,1792],[1613,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1791,"width":1370,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28b70a75cfbf43a3b3a38955db4843e1","type":"text","conversion_output":true,"text":"treatment cycle and at the end of the DBPC treatment phase (Week 104/Visit 22).","text_display":" treatment cycle and at the end of the DBPC treatment phase (Week 104/Visit 22).","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[245,1882],[1882,1882],[1882,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1882,"width":1639,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7193721a4f5d4099a254e6ae71721909","type":"text","conversion_output":true,"text":"Minor efficacy assessments will also take place at intervals of 6 months, occurring 9 weeks after","text_display":"\n\nMinor efficacy assessments will also take place at intervals of 6 months, occurring 9 weeks after","confidence":0.9975595474243164,"confidence_rate":0.9999773758546899},{"cnt":[[245,1931],[784,1931],[784,1983],[245,1983]],"region":{"top_left_x":244,"top_left_y":1931,"width":541,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01b52310b5fe4a5faf1c153d36dc3b96","type":"text","conversion_output":true,"text":"the end of each treatment cycle.","text_display":" the end of each treatment cycle.","confidence":1,"confidence_rate":1},{"cnt":[[245,2020],[1420,2020],[1420,2071],[245,2071]],"region":{"top_left_x":244,"top_left_y":2019,"width":1177,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0e420326b29400ea74a46a2d22a95ba","type":"text","conversion_output":true,"text":"Details of DBPC treatment phase visits are presented in Section 7.1.3.","text_display":"\n\nDetails of DBPC treatment phase visits are presented in Section 7.1.3.","confidence":1,"confidence_rate":1},{"cnt":[[245,2110],[1882,2110],[1882,2159],[245,2159]],"region":{"top_left_x":244,"top_left_y":2109,"width":1639,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"146c6573d72641d1b601025b6c2c76b4","type":"text","conversion_output":true,"text":"Efficacy assessments will include MRI and X-ray of the target knee, the WOMAC, the 20 -meter","text_display":"\nEfficacy assessments will include MRI and X-ray of the target knee, the WOMAC, the 20 -meter","confidence":0.998535871389322,"confidence_rate":0.999985348092397},{"cnt":[[245,2157],[1880,2157],[1880,2209],[245,2209]],"region":{"top_left_x":244,"top_left_y":2157,"width":1636,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d922a2979b044805adc46521584567e3","type":"text","conversion_output":true,"text":"walk test, and the Patient's Global Assessment of disease impact (PGA). The Knee Injury and","text_display":" walk test, and the Patient's Global Assessment of disease impact (PGA). The Knee Injury and","confidence":1,"confidence_rate":1},{"cnt":[[245,2204],[1880,2204],[1880,2258],[245,2258]],"region":{"top_left_x":244,"top_left_y":2204,"width":1636,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f9e16bc43c84d9596cfc297954745fc","type":"text","conversion_output":true,"text":"Osteoarthritis Outcome Score QOL subscale (KOOS QOL) and the Medical Outcomes Study","text_display":" Osteoarthritis Outcome Score QOL subscale (KOOS QOL) and the Medical Outcomes Study","confidence":1,"confidence_rate":1},{"cnt":[[245,2254],[1884,2254],[1884,2305],[245,2305]],"region":{"top_left_x":244,"top_left_y":2253,"width":1641,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f03bca9627c5492f81986ecf06710533","type":"text","conversion_output":true,"text":"Short Form-36 General Health Survey (MOS SF-36) will be assessed for exploratory analysis of","text_display":" Short Form-36 General Health Survey (MOS SF-36) will be assessed for exploratory analysis of","confidence":1,"confidence_rate":1},{"cnt":[[245,2299],[1880,2299],[1880,2350],[245,2350]],"region":{"top_left_x":244,"top_left_y":2298,"width":1636,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4d6adcc11e84ace9ec8bf211b17b438","type":"text","conversion_output":true,"text":"treatment effect on health-related QOL. The NRS will be used to explore treatment effect on","text_display":" treatment effect on health-related QOL. The NRS will be used to explore treatment effect on","confidence":1,"confidence_rate":1},{"cnt":[[245,2348],[1880,2348],[1880,2400],[245,2400]],"region":{"top_left_x":244,"top_left_y":2348,"width":1636,"height":52},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"257638e6d9894e39b8350bae457b39c1","type":"text","conversion_output":true,"text":"worst pain in the past 24 hours in the target knee. The Measure of Intermittent and Constant","text_display":" worst pain in the past 24 hours in the target knee. The Measure of Intermittent and Constant","confidence":0.99853515625,"confidence_rate":0.9999853409306202},{"cnt":[[245,2398],[1880,2398],[1880,2447],[245,2447]],"region":{"top_left_x":244,"top_left_y":2397,"width":1636,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9df2d8be0f94c2e94c7e9762865473f","type":"text","conversion_output":true,"text":"Osteoarthritis Pain (ICOAP) and the KOOS Symptom Index questionnaires will be used to","text_display":" Osteoarthritis Pain (ICOAP) and the KOOS Symptom Index questionnaires will be used to","confidence":1,"confidence_rate":1},{"cnt":[[245,2445],[1882,2445],[1882,2496],[245,2496]],"region":{"top_left_x":244,"top_left_y":2444,"width":1639,"height":53},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8286e79f457746acb5560092596b5658","type":"text","conversion_output":true,"text":"explore treatment effect on OA-related symptomatology in the target knee. The NRS pain scale","text_display":" explore treatment effect on OA-related symptomatology in the target knee. The NRS pain scale","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"615dc155b6f145e99547ca1236f135db","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2546],[389,2544],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2543,"width":146,"height":44},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"24edd33fb10e4ea9929be9db9698ce32","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62e5338e64bb4828a89fe0cac0f885f6","type":"page_info","conversion_output":false,"text":"34/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-035","page":35,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2647b1ed851741dbac5bc637249b034a","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a44b66a062954190b50eb00342a4f2cc","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2873d11648b84999a385e30778720cd6","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b34265fd0648401685241e9e2403b985","type":"text","conversion_output":true,"text":"for the contralateral knee and a scale model of the human body (homunculus) identifying","text_display":"\nfor the contralateral knee and a scale model of the human body (homunculus) identifying","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[243,327],[1884,327],[1884,380],[243,380]],"region":{"top_left_x":242,"top_left_y":326,"width":1643,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d5bbe6b1e2540578810eeb6f49f4dfe","type":"text","conversion_output":true,"text":"potentially painful joints will be used to assess pain in non-target joints and the progression of","text_display":" potentially painful joints will be used to assess pain in non-target joints and the progression of","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1882,374],[1882,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1639,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"184fcf97e15b4ebeab49214f08a74403","type":"text","conversion_output":true,"text":"OA. The Patient Global Impression of Change (PGIC) will be used to measure the subject's","text_display":" OA. The Patient Global Impression of Change (PGIC) will be used to measure the subject's","confidence":0.998046875,"confidence_rate":0.9999789783410032},{"cnt":[[245,423],[1882,423],[1882,475],[245,475]],"region":{"top_left_x":244,"top_left_y":423,"width":1639,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6245cc6f49474fe696b906dbddb08075","type":"text","conversion_output":true,"text":"assessment of the clinical importance of their improvement or worsening over the course of the","text_display":" assessment of the clinical importance of their improvement or worsening over the course of the","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[333,473],[333,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":90,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8438d6689b2a4d89a419bff437c62ac4","type":"text","conversion_output":true,"text":"trial.","text_display":" trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af150a4cbc8344a2b0a781ad77716543","type":"text","conversion_output":true,"text":"At specified visits, blood samples will be collected for measurement of serum sprifermin/FGF-18","text_display":"\n\nAt specified visits, blood samples will be collected for measurement of serum sprifermin/FGF-18","confidence":0.998046875,"confidence_rate":0.9999804498427488},{"cnt":[[245,608],[1880,608],[1880,660],[245,660]],"region":{"top_left_x":244,"top_left_y":608,"width":1636,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12e04317b0f34a83b48143d7cd39bc6f","type":"text","conversion_output":true,"text":"levels and biomarkers, and urine will be collected for measurement of biomarkers (see Section","text_display":" levels and biomarkers, and urine will be collected for measurement of biomarkers (see Section","confidence":1,"confidence_rate":1},{"cnt":[[245,657],[1880,657],[1880,707],[245,707]],"region":{"top_left_x":244,"top_left_y":657,"width":1636,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02f041cee1cb4243b996e7a2f9f32187","type":"text","conversion_output":true,"text":"7.6). These biomarker specimens will be collected after an 8 -hour fast. At visits where IMP is","text_display":" 7.6). These biomarker specimens will be collected after an 8 -hour fast. At visits where IMP is","confidence":0.9990234375,"confidence_rate":0.9999905142231666},{"cnt":[[245,705],[1884,705],[1884,758],[245,758]],"region":{"top_left_x":244,"top_left_y":704,"width":1641,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92654bdd6da64f60bd0442d14b2d5aae","type":"text","conversion_output":true,"text":"injected, samples of synovial fluid will be collected for PK and biomarker assessment as part of","text_display":" injected, samples of synovial fluid will be collected for PK and biomarker assessment as part of","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[245,752],[1682,752],[1682,806],[245,806]],"region":{"top_left_x":244,"top_left_y":751,"width":1439,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98b8050cc51043428ccb93a62de9a912","type":"text","conversion_output":true,"text":"the i.a. injection procedure, using the same needle that will be used for IMP injection.","text_display":" the i.a. injection procedure, using the same needle that will be used for IMP injection.","confidence":0.9990234375,"confidence_rate":0.9999894942525209},{"cnt":[[245,842],[1871,842],[1871,896],[245,896]],"region":{"top_left_x":244,"top_left_y":842,"width":1628,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a98500cab9724b2eb3660475d349358a","type":"text","conversion_output":true,"text":"Exploratory PGt analyses will be performed for subjects who provide separate informed consent.","text_display":"\n\nExploratory PGt analyses will be performed for subjects who provide separate informed consent.","confidence":1,"confidence_rate":1},{"cnt":[[245,932],[1880,932],[1880,982],[245,982]],"region":{"top_left_x":244,"top_left_y":932,"width":1636,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d88d82162db7497db991e5650a62b8c9","type":"text","conversion_output":true,"text":"AEs and concomitant medications and procedures will be monitored throughout the trial, and","text_display":"\nAEs and concomitant medications and procedures will be monitored throughout the trial, and","confidence":1,"confidence_rate":1},{"cnt":[[245,980],[1880,980],[1880,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":979,"width":1636,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98c885b540b44f91af7439f8f49877c2","type":"text","conversion_output":true,"text":"vital signs will be measured at each trial visit. Safety assessments will also include 12-lead","text_display":" vital signs will be measured at each trial visit. Safety assessments will also include 12-lead","confidence":1,"confidence_rate":1},{"cnt":[[245,1027],[1882,1027],[1882,1081],[245,1081]],"region":{"top_left_x":244,"top_left_y":1026,"width":1639,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4282b989441c448f800d148c9aa980e2","type":"text","conversion_output":true,"text":"electrocardiograms (ECGs), physical examination, weight measurements, safety laboratory","text_display":" electrocardiograms (ECGs), physical examination, weight measurements, safety laboratory","confidence":1,"confidence_rate":1},{"cnt":[[245,1076],[1880,1076],[1880,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1076,"width":1636,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b2c04aa4f824d5485b1b1152a6a56ff","type":"text","conversion_output":true,"text":"analyses (hematology, biochemistry, and urinalysis), and testing for antibodies to","text_display":" analyses (hematology, biochemistry, and urinalysis), and testing for antibodies to","confidence":1,"confidence_rate":1},{"cnt":[[245,1124],[1880,1124],[1880,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1123,"width":1636,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5962d0a7cc8743b39fc69c14f2ab5f56","type":"text","conversion_output":true,"text":"sprifermin/FGF-18. Height will be measured at screening and at the end of the DBPC and","text_display":" sprifermin/FGF-18. Height will be measured at screening and at the end of the DBPC and","confidence":0.9990234375,"confidence_rate":0.9999892633582115},{"cnt":[[245,1173],[1880,1173],[1880,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1636,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2182da866061426bb5efb113d7f4f0c2","type":"text","conversion_output":true,"text":"extended follow-up phases. Data regarding any surgical procedures on the target knee will also","text_display":" extended follow-up phases. Data regarding any surgical procedures on the target knee will also","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[462,1220],[462,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1220,"width":218,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fb003db439741c6bfa7869dcf035b64","type":"text","conversion_output":true,"text":"be collected.","text_display":" be collected.","confidence":1,"confidence_rate":1},{"cnt":[[245,1308],[1880,1308],[1880,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1308,"width":1636,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0cc418d87d1402e9ba85d16784e3d72","type":"text","conversion_output":true,"text":"Subjects will use trial diaries to record information about AEs, concomitant medications, and","text_display":"\n\nSubjects will use trial diaries to record information about AEs, concomitant medications, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1358],[1880,1358],[1880,1407],[245,1407]],"region":{"top_left_x":244,"top_left_y":1357,"width":1636,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d89131cf7ee40649b217c8562169f32","type":"text","conversion_output":true,"text":"local tolerability between trial visits. Diary information about maximum levels of target knee","text_display":" local tolerability between trial visits. Diary information about maximum levels of target knee","confidence":1,"confidence_rate":1},{"cnt":[[245,1405],[1880,1405],[1880,1457],[245,1457]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b8a37ed56254ef19b261b88f2a70712","type":"text","conversion_output":true,"text":"pain and presence or absence of target knee swelling will be used to identify potential acute","text_display":" pain and presence or absence of target knee swelling will be used to identify potential acute","confidence":1,"confidence_rate":1},{"cnt":[[245,1452],[1171,1452],[1171,1504],[245,1504]],"region":{"top_left_x":244,"top_left_y":1452,"width":927,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"761bf461a6854ff0bc891bdd99ac37f2","type":"text","conversion_output":true,"text":"inflammatory reactions (AIRs) to the IMP (see below).","text_display":" inflammatory reactions (AIRs) to the IMP (see below).","confidence":1,"confidence_rate":1},{"cnt":[[241,1538],[741,1538],[741,1601],[241,1601]],"region":{"top_left_x":240,"top_left_y":1538,"width":502,"height":63},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e9d205e462140b488ae3abf625ab642","type":"section_header","conversion_output":false,"children_ids":["58f0408051b2411ca9f67e4a89d74272"],"text":"","text_display":""},{"cnt":[[245,1543],[737,1543],[737,1596],[245,1596]],"region":{"top_left_x":244,"top_left_y":1542,"width":493,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58f0408051b2411ca9f67e4a89d74272","type":"text","conversion_output":true,"parent_id":"4e9d205e462140b488ae3abf625ab642","text":"Extended Follow-Up Phase","text_display":"\n\n\\section*{Extended Follow-Up Phase}","confidence":1,"confidence_rate":1},{"cnt":[[245,1633],[1880,1633],[1880,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10ebde6f8f624590ba0d8fa34e20c707","type":"text","conversion_output":true,"text":"Subjects who complete the DBPC treatment phase visits will be followed for a further 3 years,","text_display":"\n\nSubjects who complete the DBPC treatment phase visits will be followed for a further 3 years,","confidence":1,"confidence_rate":1},{"cnt":[[245,1680],[1373,1680],[1373,1729],[245,1729]],"region":{"top_left_x":244,"top_left_y":1680,"width":1129,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea7a7baa2c9a4e218dbe5a0f60d7e20a","type":"text","conversion_output":true,"text":"during which trial assessments will take place at 6 -month intervals.","text_display":" during which trial assessments will take place at 6 -month intervals.","confidence":0.99853515625,"confidence_rate":0.999980962289239},{"cnt":[[245,1770],[1880,1770],[1880,1820],[245,1820]],"region":{"top_left_x":244,"top_left_y":1770,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6afa85e25ede49418ef103d5ba30865f","type":"text","conversion_output":true,"text":"Safety assessments will be performed and the WOMAC, NRS pain in the target and contralateral","text_display":"\n\nSafety assessments will be performed and the WOMAC, NRS pain in the target and contralateral","confidence":1,"confidence_rate":1},{"cnt":[[245,1818],[1880,1818],[1880,1869],[245,1869]],"region":{"top_left_x":244,"top_left_y":1817,"width":1636,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27ac6d5b43d54cbd90801e3113f6712b","type":"text","conversion_output":true,"text":"knee, KOOS QOL, KOOS Symptom Index, MOS SF-36, PGA, PGIC, identification of pain in","text_display":" knee, KOOS QOL, KOOS Symptom Index, MOS SF-36, PGA, PGIC, identification of pain in","confidence":1,"confidence_rate":1},{"cnt":[[245,1865],[1880,1865],[1880,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1864,"width":1636,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5dee354df44545d892c14b2a6753cf1c","type":"text","conversion_output":true,"text":"other joints, ICOAP, and 20 -meter walk test will be assessed at each visit during the follow-up","text_display":" other joints, ICOAP, and 20 -meter walk test will be assessed at each visit during the follow-up","confidence":0.8720703125,"confidence_rate":0.9986846617328151},{"cnt":[[245,1916],[1253,1916],[1253,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1916,"width":1009,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e06cc7c4fd248c5b6a15b411d44c635","type":"text","conversion_output":true,"text":"phase. MRI and X-ray will be performed at yearly intervals.","text_display":" phase. MRI and X-ray will be performed at yearly intervals.","confidence":0.99755859375,"confidence_rate":0.9999618071146515},{"cnt":[[241,1998],[544,1998],[544,2060],[241,2060]],"region":{"top_left_x":240,"top_left_y":1998,"width":304,"height":63},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6239309b2f5b4bedbc9bb1536e290569","type":"section_header","conversion_output":false,"children_ids":["d490118d7ee04fb890bbeec628fd558b"],"text":"","text_display":""},{"cnt":[[245,2004],[539,2004],[539,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2004,"width":296,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d490118d7ee04fb890bbeec628fd558b","type":"text","conversion_output":true,"parent_id":"6239309b2f5b4bedbc9bb1536e290569","text":"Trial Endpoints","text_display":"\n\n\\section*{Trial Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1880,2093],[1880,2144],[245,2144]],"region":{"top_left_x":244,"top_left_y":2092,"width":1636,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20a23f9f3e9b4965932a0d2ff27da123","type":"text","conversion_output":true,"text":"The primary endpoint of this trial is change from baseline in cartilage thickness in the total","text_display":"\n\nThe primary endpoint of this trial is change from baseline in cartilage thickness in the total","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,2140],[1085,2140],[1085,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2139,"width":841,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"100194401295473dbe3a7d0c1746a79d","type":"text","conversion_output":true,"text":"femorotibial joint as evaluated by MRI at 2 years.","text_display":" femorotibial joint as evaluated by MRI at 2 years.","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[672,2230],[672,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":429,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bccf27af6fb34d76b533291ed4bbccbc","type":"text","conversion_output":true,"text":"Secondary endpoints are:","text_display":"\n\nSecondary endpoints are:","confidence":1,"confidence_rate":1},{"cnt":[[245,2299],[1880,2299],[1880,2353],[245,2353]],"region":{"top_left_x":244,"top_left_y":2298,"width":1636,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de8fc3d66e024b58a044b253ad474cf4","type":"text","conversion_output":true,"text":"- Changes from baseline in the WOMAC total score and in the WOMAC pain, function, and","text_display":"\n- Changes from baseline in the WOMAC total score and in the WOMAC pain, function, and","confidence":1,"confidence_rate":1},{"cnt":[[294,2350],[874,2350],[874,2400],[294,2400]],"region":{"top_left_x":294,"top_left_y":2350,"width":581,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc10079a53cb464eaa54640103462f5a","type":"text","conversion_output":true,"text":"stiffness index scores over 2 years","text_display":" stiffness index scores over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,2419],[1308,2419],[1308,2473],[245,2473]],"region":{"top_left_x":244,"top_left_y":2419,"width":1065,"height":54},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21445dfce64d4bbf9e753efe19e2e9da","type":"text","conversion_output":true,"text":"- Change from baseline in the 20 -meter walk test over 2 years","text_display":"\n- Change from baseline in the 20 -meter walk test over 2 years","confidence":0.978515625,"confidence_rate":0.9997025302261334},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3657bc04d44745af9bfccb9de2193f8e","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":42},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ec90b46d8b4a4d1fa120147b2473f49c","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec637acaba1b4a6e8523d8c8e25c6e84","type":"page_info","conversion_output":false,"text":"35/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-036","page":36,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e949322c47c4f6cadc335a5f5d2e897","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68a0bdec60bf40b6adf3b6f7fe44af34","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1225f7dcd123430bbcf4c61c63c834c2","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,284],[1085,284],[1085,333],[245,333]],"region":{"top_left_x":244,"top_left_y":283,"width":841,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f50370a695f344f09f31e3c3ce9ae5a0","type":"text","conversion_output":true,"text":"- Change from baseline in the PGA over 2 years","text_display":"\n- Change from baseline in the PGA over 2 years","confidence":0.99951171875,"confidence_rate":0.9999909555872323},{"cnt":[[245,352],[1882,352],[1882,406],[245,406]],"region":{"top_left_x":244,"top_left_y":352,"width":1639,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c298af899215432fa279072b92c589ff","type":"text","conversion_output":true,"text":"- Change from baseline in minimal joint space width (JSW) in the medial and lateral","text_display":"\n- Change from baseline in minimal joint space width (JSW) in the medial and lateral","confidence":1,"confidence_rate":1},{"cnt":[[292,404],[1130,404],[1130,453],[292,453]],"region":{"top_left_x":292,"top_left_y":403,"width":839,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c083b67ca00b4fadb49606a2e068a7df","type":"text","conversion_output":true,"text":"compartments as evaluated by X-ray over 2 years","text_display":" compartments as evaluated by X-ray over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1882,473],[1882,526],[245,526]],"region":{"top_left_x":244,"top_left_y":472,"width":1639,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7f8804bb78c4104938554c41ff3e44a","type":"text","conversion_output":true,"text":"- Change from baseline in cartilage thickness in the medial and lateral compartments as well as","text_display":"\n- Change from baseline in cartilage thickness in the medial and lateral compartments as well as","confidence":1,"confidence_rate":1},{"cnt":[[292,524],[999,524],[999,574],[292,574]],"region":{"top_left_x":292,"top_left_y":524,"width":708,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d977baf8d2747089004c6577f1c174d","type":"text","conversion_output":true,"text":"in the total femorotibial joint over 2 years","text_display":" in the total femorotibial joint over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,593],[1882,593],[1882,647],[245,647]],"region":{"top_left_x":244,"top_left_y":592,"width":1639,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2acb86c8062a451ca185d5affaa7f473","type":"text","conversion_output":true,"text":"- Change from baseline in cartilage volume in the medial and lateral compartments as well as in","text_display":"\n- Change from baseline in cartilage volume in the medial and lateral compartments as well as in","confidence":1,"confidence_rate":1},{"cnt":[[292,645],[956,645],[956,694],[292,694]],"region":{"top_left_x":292,"top_left_y":644,"width":665,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ec554f70b9b429b8ca7fb1a313d8201","type":"text","conversion_output":true,"text":"the total femorotibial joint over 2 years","text_display":" the total femorotibial joint over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,713],[1021,713],[1021,767],[245,767]],"region":{"top_left_x":244,"top_left_y":713,"width":777,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee8ade4617024835a1269aea2ca26740","type":"text","conversion_output":true,"text":"- Synovial fluid levels of sprifermin/FGF-18","text_display":"\n- Synovial fluid levels of sprifermin/FGF-18","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[896,786],[896,838],[245,838]],"region":{"top_left_x":244,"top_left_y":786,"width":652,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c56cdf32bc1b4f25bc96e5808f2046f0","type":"text","conversion_output":true,"text":"- Serum levels of sprifermin/FGF-18","text_display":"\n- Serum levels of sprifermin/FGF-18","confidence":1,"confidence_rate":1},{"cnt":[[245,872],[604,872],[604,926],[245,926]],"region":{"top_left_x":244,"top_left_y":872,"width":360,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"105aa61e2b2c4330ab0abe9a1ba582a2","type":"text","conversion_output":true,"text":"Safety endpoints are:","text_display":"\n\nSafety endpoints are:","confidence":1,"confidence_rate":1},{"cnt":[[245,947],[1257,947],[1257,999],[245,999]],"region":{"top_left_x":244,"top_left_y":947,"width":1013,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa04217c42514357b850a47831d92b74","type":"text","conversion_output":true,"text":"- Nature, incidence and severity of local and systemic AEs","text_display":"\n- Nature, incidence and severity of local and systemic AEs","confidence":1,"confidence_rate":1},{"cnt":[[245,1018],[1882,1018],[1882,1070],[245,1070]],"region":{"top_left_x":244,"top_left_y":1018,"width":1639,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d280935c6ddf4a9484b5f378c88000cb","type":"text","conversion_output":true,"text":"- Incidence of acute inflammatory reactions (AIRs), defined as increase of pain by 30 mm on a","text_display":"\n- Incidence of acute inflammatory reactions (AIRs), defined as increase of pain by 30 mm on a","confidence":1,"confidence_rate":1},{"cnt":[[296,1066],[1880,1066],[1880,1119],[296,1119]],"region":{"top_left_x":296,"top_left_y":1065,"width":1584,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5c40ac465e94b5d800254251ad2aee9","type":"text","conversion_output":true,"text":"100 mm VAS and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days","text_display":" 100 mm VAS and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days","confidence":0.9204487800598145,"confidence_rate":0.999171404240573},{"cnt":[[294,1113],[1036,1113],[1036,1167],[294,1167]],"region":{"top_left_x":294,"top_left_y":1112,"width":742,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afe22c6f814041c0aa839166c431ea6f","type":"text","conversion_output":true,"text":"following i.a. injection (see Section 7.4.1.1)","text_display":" following i.a. injection (see Section 7.4.1.1)","confidence":1,"confidence_rate":1},{"cnt":[[245,1186],[1882,1186],[1882,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1185,"width":1639,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51ea61c9664a40c29b41d6a9dc86da81","type":"text","conversion_output":true,"text":"- Changes in laboratory safety parameters, vital signs, 12-lead ECG parameters, weight, and","text_display":"\n- Changes in laboratory safety parameters, vital signs, 12-lead ECG parameters, weight, and","confidence":0.970703125,"confidence_rate":0.9996903125574037},{"cnt":[[292,1233],[677,1233],[677,1287],[292,1287]],"region":{"top_left_x":292,"top_left_y":1233,"width":385,"height":54},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38541de534394c53a56451ac901e38e0","type":"text","conversion_output":true,"text":"physical examinations","text_display":" physical examinations","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1880,1306],[1880,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1306,"width":1636,"height":54},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dde1fc91272a479981303904a9014026","type":"text","conversion_output":true,"text":"- Incidence of surgical interventions in the target knee (including any surgical revision,","text_display":"\n- Incidence of surgical interventions in the target knee (including any surgical revision,","confidence":1,"confidence_rate":1},{"cnt":[[294,1354],[1313,1354],[1313,1407],[294,1407]],"region":{"top_left_x":294,"top_left_y":1353,"width":1019,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01c9323b2be24db2905c6e99c91f2ec1","type":"text","conversion_output":true,"text":"cartilage removal, or any other type of surgical intervention)","text_display":" cartilage removal, or any other type of surgical intervention)","confidence":1,"confidence_rate":1},{"cnt":[[245,1427],[1510,1427],[1510,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1426,"width":1267,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52cae52343894d00b0cc45944b086dad","type":"text","conversion_output":true,"text":"- Occurrence of binding and neutralizing antibodies to sprifermin/FGF-18","text_display":"\n- Occurrence of binding and neutralizing antibodies to sprifermin/FGF-18","confidence":0.9970703125,"confidence_rate":0.9999618969930187},{"cnt":[[245,1517],[698,1517],[698,1566],[245,1566]],"region":{"top_left_x":244,"top_left_y":1516,"width":455,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b6c357251034505854dfbe3abf1177f","type":"text","conversion_output":true,"text":"Exploratory endpoints are:","text_display":"\n\nExploratory endpoints are:","confidence":1,"confidence_rate":1},{"cnt":[[245,1586],[1880,1586],[1880,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1585,"width":1636,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03da120f4d2c40958a9e419583ddd739","type":"text","conversion_output":true,"text":"- Outcome Measures in Rheumatology - Osteoarthritis Research Society International","text_display":"\n- Outcome Measures in Rheumatology - Osteoarthritis Research Society International","confidence":1,"confidence_rate":1},{"cnt":[[294,1635],[1154,1635],[1154,1687],[294,1687]],"region":{"top_left_x":294,"top_left_y":1634,"width":860,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6255bdb7c3c4bbc8039d33f266d90ac","type":"text","conversion_output":true,"text":"(OMERACT-OARSI) responder rate (1) at 2 years","text_display":" (OMERACT-OARSI) responder rate (1) at 2 years","confidence":0.99951171875,"confidence_rate":0.9999907849387211},{"cnt":[[245,1706],[612,1706],[612,1760],[245,1760]],"region":{"top_left_x":244,"top_left_y":1705,"width":369,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af652e4fe57b40a3a52dc6b35ceaca17","type":"text","conversion_output":true,"text":"- PGIC over 2 years","text_display":"\n- PGIC over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,1777],[1882,1777],[1882,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1776,"width":1639,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05c94d8c03804f199255e4e943f41705","type":"text","conversion_output":true,"text":"- Changes from baseline in the scores of the KOOS QOL and the MOS SF-36 questionnaire","text_display":"\n- Changes from baseline in the scores of the KOOS QOL and the MOS SF-36 questionnaire","confidence":1,"confidence_rate":1},{"cnt":[[292,1826],[509,1826],[509,1876],[292,1876]],"region":{"top_left_x":292,"top_left_y":1826,"width":218,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ce90db85a964dff9f7476243afcecca","type":"text","conversion_output":true,"text":"over 2 years","text_display":" over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,1899],[1328,1899],[1328,1949],[245,1949]],"region":{"top_left_x":244,"top_left_y":1899,"width":1084,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1520b0c138334778a8d02e7fe949814d","type":"text","conversion_output":true,"text":"- Change from baseline in KOOS Symptom Index over 2 years","text_display":"\n- Change from baseline in KOOS Symptom Index over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1880,1968],[1880,2022],[245,2022]],"region":{"top_left_x":244,"top_left_y":1967,"width":1636,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbe61ce18b4f45808821b49e2cf06f43","type":"text","conversion_output":true,"text":"- Change from baseline in NRS pain score in the target and contralateral knee over 2 years","text_display":"\n- Change from baseline in NRS pain score in the target and contralateral knee over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[292,2020],[685,2020],[685,2069],[292,2069]],"region":{"top_left_x":292,"top_left_y":2019,"width":394,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b168c0ba5fdb49a79d9eb48d2123af7b","type":"text","conversion_output":true,"text":"using an 11-point NRS","text_display":" using an 11-point NRS","confidence":0.9990234375,"confidence_rate":0.9999624222580676},{"cnt":[[245,2088],[1450,2088],[1450,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2088,"width":1207,"height":54},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10d606ca9d234ab3a92c9c6ee76082b2","type":"text","conversion_output":true,"text":"- Change from baseline in presence of pain in other joints over 2 years","text_display":"\n- Change from baseline in presence of pain in other joints over 2 years","confidence":0.99755859375,"confidence_rate":0.9999690588161342},{"cnt":[[245,2161],[1175,2161],[1175,2213],[245,2213]],"region":{"top_left_x":244,"top_left_y":2161,"width":932,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"319b58e1914c4cc68a56a1c51a749692","type":"text","conversion_output":true,"text":"- Change from baseline in ICOAP scores over 2 years","text_display":"\n- Change from baseline in ICOAP scores over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,2234],[1880,2234],[1880,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2234,"width":1636,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53df91b2095d47bf971dd61473945afc","type":"text","conversion_output":true,"text":"- Change over time in structural as well as compositional parameters of the knee joint (e.g.,","text_display":"\n- Change over time in structural as well as compositional parameters of the knee joint (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[294,2282],[1523,2282],[1523,2331],[294,2331]],"region":{"top_left_x":294,"top_left_y":2281,"width":1230,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e90d1c0e58f4cb78f6e3368b5624fab","type":"text","conversion_output":true,"text":"e.g., synovium, menisci, bone, and other structures) as evaluated by MRI","text_display":" e.g., synovium, menisci, bone, and other structures) as evaluated by MRI","confidence":0.99951171875,"confidence_rate":0.9999936571565041},{"cnt":[[245,2350],[1884,2350],[1884,2404],[245,2404]],"region":{"top_left_x":244,"top_left_y":2350,"width":1641,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"078e2e3c3bfa4206bb83ffd8640d7368","type":"text","conversion_output":true,"text":"- Change from baseline in serum, urine, and synovial markers associated with administration of","text_display":"\n- Change from baseline in serum, urine, and synovial markers associated with administration of","confidence":1,"confidence_rate":1},{"cnt":[[292,2402],[544,2402],[544,2451],[292,2451]],"region":{"top_left_x":292,"top_left_y":2401,"width":252,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72d624d01c904ecf931f2e0a0df1445a","type":"text","conversion_output":true,"text":"the compound","text_display":" the compound","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6cb026fee33d48e897566bf156e59edf","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"593045a8b1694913b9babb3bc2a59065","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c65c24fb36d64229ae8df59f8b7fb9fd","type":"page_info","conversion_output":false,"text":"36/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-037","page":37,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"222ef6fecbd44aafae3087640a7760c0","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45e3227052d1408f9319ce16d7a85ccd","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00c0fdecd7d840249a58540b24e1d069","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,284],[1884,284],[1884,333],[245,333]],"region":{"top_left_x":244,"top_left_y":283,"width":1641,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36a080dac250469c946f23a66459879c","type":"text","conversion_output":true,"text":"- Baseline protein markers and/or genetic markers associated with response to treatment or","text_display":"\n- Baseline protein markers and/or genetic markers associated with response to treatment or","confidence":1,"confidence_rate":1},{"cnt":[[294,331],[1457,331],[1457,385],[294,385]],"region":{"top_left_x":294,"top_left_y":330,"width":1163,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6e110bc18c54228a161518dbca60932","type":"text","conversion_output":true,"text":"disease progression (response assessed by MRI and/or questionnaire)","text_display":" disease progression (response assessed by MRI and/or questionnaire)","confidence":1,"confidence_rate":1},{"cnt":[[245,402],[1880,402],[1880,453],[245,453]],"region":{"top_left_x":244,"top_left_y":401,"width":1636,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5dabf8b8338447d3b381278f564e6bbb","type":"text","conversion_output":true,"text":"- Changes in MRI outcomes, WOMAC scores, 20 -meter walk test, PGA, PGIC, JSW,","text_display":"\n- Changes in MRI outcomes, WOMAC scores, 20 -meter walk test, PGA, PGIC, JSW,","confidence":0.79296875,"confidence_rate":0.99727464447879},{"cnt":[[292,451],[1880,451],[1880,501],[292,501]],"region":{"top_left_x":292,"top_left_y":451,"width":1588,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c332a0c893ce4cb4af0ee375529fd1ed","type":"text","conversion_output":true,"text":"OMERACT-OARSI responder rate, KOOS QOL, KOOS Symptom Index, MOS SF-36, NRS","text_display":" OMERACT-OARSI responder rate, KOOS QOL, KOOS Symptom Index, MOS SF-36, NRS","confidence":1,"confidence_rate":1},{"cnt":[[292,498],[1880,498],[1880,552],[292,552]],"region":{"top_left_x":292,"top_left_y":498,"width":1588,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4efe959b2c594ce18dc18917c5065c4b","type":"text","conversion_output":true,"text":"pain score in the target and contralateral knee, presence of pain in other joints, ICOAP, safety","text_display":" pain score in the target and contralateral knee, presence of pain in other joints, ICOAP, safety","confidence":1,"confidence_rate":1},{"cnt":[[294,546],[1880,546],[1880,597],[294,597]],"region":{"top_left_x":294,"top_left_y":545,"width":1586,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d229ccdcdd94aec97562db125699f7f","type":"text","conversion_output":true,"text":"laboratory values, and vital signs over the extended follow-up period and nature, incidence","text_display":" laboratory values, and vital signs over the extended follow-up period and nature, incidence","confidence":1,"confidence_rate":1},{"cnt":[[292,593],[1880,593],[1880,647],[292,647]],"region":{"top_left_x":292,"top_left_y":592,"width":1588,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da71c8e9a17e422c8c71b2e515f41589","type":"text","conversion_output":true,"text":"and severity of local and systemic AEs during the extended follow-up period (to be","text_display":" and severity of local and systemic AEs during the extended follow-up period (to be","confidence":1,"confidence_rate":1},{"cnt":[[292,645],[746,645],[746,694],[292,694]],"region":{"top_left_x":292,"top_left_y":644,"width":454,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0fff0c13bc446c1af0f89e7693447d1","type":"text","conversion_output":true,"text":"summarized descriptively)","text_display":" summarized descriptively)","confidence":1,"confidence_rate":1},{"cnt":[[245,713],[1882,713],[1882,767],[245,767]],"region":{"top_left_x":244,"top_left_y":713,"width":1639,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea48878c374e433093277ce7dbf0daed","type":"text","conversion_output":true,"text":"- Relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a","text_display":"\n- Relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a","confidence":1,"confidence_rate":1},{"cnt":[[292,765],[574,765],[574,810],[292,810]],"region":{"top_left_x":292,"top_left_y":764,"width":282,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd7fa77feca5416985d3198b1c97b7fb","type":"text","conversion_output":true,"text":"function of time","text_display":" function of time","confidence":1,"confidence_rate":1},{"cnt":[[245,851],[1420,851],[1420,904],[245,904]],"region":{"top_left_x":244,"top_left_y":850,"width":1177,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9eb6279535fb48168564d63999496129","type":"text","conversion_output":true,"text":"Details of trial endpoints and their analysis are presented in Section 8.","text_display":"\n\nDetails of trial endpoints and their analysis are presented in Section 8.","confidence":1,"confidence_rate":1},{"cnt":[[236,937],[947,937],[947,999],[236,999]],"region":{"top_left_x":236,"top_left_y":936,"width":712,"height":64},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4dff9697ec4d4568bc3fe726c87c73b9","type":"section_header","conversion_output":false,"children_ids":["3d7440f4844e4befa06477e8ad3f06e0"],"text":"","text_display":""},{"cnt":[[245,941],[943,941],[943,995],[245,995]],"region":{"top_left_x":244,"top_left_y":941,"width":700,"height":54},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d7440f4844e4befa06477e8ad3f06e0","type":"text","conversion_output":true,"parent_id":"4dff9697ec4d4568bc3fe726c87c73b9","text":"Interim Analysis and Data Monitoring","text_display":"\n\n\\section*{Interim Analysis and Data Monitoring}","confidence":1,"confidence_rate":1},{"cnt":[[245,1031],[771,1031],[771,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1031,"width":528,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20955a0d50cc40a1aa58e20be6136037","type":"text","conversion_output":true,"text":"No interim analysis is planned.","text_display":"\n\nNo interim analysis is planned.","confidence":1,"confidence_rate":1},{"cnt":[[245,1121],[1880,1121],[1880,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1121,"width":1636,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d260e38ca1b4008a2879627b6dc4350","type":"text","conversion_output":true,"text":"An IDMC will be constituted and will perform periodic reviews to evaluate the safety of the","text_display":"\nAn IDMC will be constituted and will perform periodic reviews to evaluate the safety of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1169],[1882,1169],[1882,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1168,"width":1639,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10cf5b070a864baba7eb6ae4dfb876fc","type":"text","conversion_output":true,"text":"subjects participating in the trial on an ongoing basis. Detailed description of the safety","text_display":" subjects participating in the trial on an ongoing basis. Detailed description of the safety","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1222,1216],[1222,1268],[245,1268]],"region":{"top_left_x":244,"top_left_y":1216,"width":979,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddc8e06814ee4d528b64d02c55bb89ca","type":"text","conversion_output":true,"text":"monitoring will be specified in a dedicated IDMC charter.","text_display":" monitoring will be specified in a dedicated IDMC charter.","confidence":1,"confidence_rate":1},{"cnt":[[236,1300],[793,1300],[793,1360],[236,1360]],"region":{"top_left_x":236,"top_left_y":1299,"width":557,"height":61},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f45ba4afacb45c6ac80cba70253c082","type":"section_header","conversion_output":false,"children_ids":["dfd258bf0b6645a585589ed619b0fb03"],"text":"","text_display":""},{"cnt":[[245,1306],[786,1306],[786,1354],[245,1354]],"region":{"top_left_x":244,"top_left_y":1306,"width":543,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfd258bf0b6645a585589ed619b0fb03","type":"text","conversion_output":true,"parent_id":"3f45ba4afacb45c6ac80cba70253c082","text":"Planned Duration of the Trial","text_display":"\n\n\\section*{Planned Duration of the Trial}","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1661,1396],[1661,1448],[245,1448]],"region":{"top_left_x":244,"top_left_y":1396,"width":1417,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75d6566025d34eeaab7d7ad1c43d7679","type":"text","conversion_output":true,"text":"It is estimated that the subject recruitment period for this trial will be up to one year.","text_display":"\n\nIt is estimated that the subject recruitment period for this trial will be up to one year.","confidence":1,"confidence_rate":1},{"cnt":[[245,1485],[1884,1485],[1884,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1484,"width":1641,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06c0c78c143541439eda6d47837b9fc0","type":"text","conversion_output":true,"text":"It is anticipated that the first subject's first visit will take place in Aug 2013 and that the last","text_display":"\nIt is anticipated that the first subject's first visit will take place in Aug 2013 and that the last","confidence":1,"confidence_rate":1},{"cnt":[[245,1534],[1553,1534],[1553,1586],[245,1586]],"region":{"top_left_x":244,"top_left_y":1533,"width":1310,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbcc20a07d354e4c885f09ac002c2c89","type":"text","conversion_output":true,"text":"subject's last visit (extended follow-up phase) will take place in August 2019.","text_display":" subject's last visit (extended follow-up phase) will take place in August 2019.","confidence":0.9970703125,"confidence_rate":0.9999646513785749},{"cnt":[[245,1624],[1880,1624],[1880,1674],[245,1674]],"region":{"top_left_x":244,"top_left_y":1624,"width":1636,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"865f1f6797dc4203913d9e985dc480d8","type":"text","conversion_output":true,"text":"It is planned to perform the statistical analysis in two steps, as described in Section 8.5.1: results","text_display":"\n\nIt is planned to perform the statistical analysis in two steps, as described in Section 8.5.1: results","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,1671],[1880,1671],[1880,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1671,"width":1636,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f0e1459c6ea48459020195bf05f74ea","type":"text","conversion_output":true,"text":"from the DBPC treatment phase will be analyzed and reported at the end of this phase, and long-","text_display":" from the DBPC treatment phase will be analyzed and reported at the end of this phase, and long","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1719],[1880,1719],[1880,1768],[245,1768]],"region":{"top_left_x":244,"top_left_y":1718,"width":1636,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9899ffb182014b24a2a486d25b2e7244","type":"text","conversion_output":true,"text":"term follow-up data will be analyzed and reported separately. MRI readers, Investigators, and","text_display":"term follow-up data will be analyzed and reported separately. MRI readers, Investigators, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1766],[1356,1766],[1356,1818],[245,1818]],"region":{"top_left_x":244,"top_left_y":1766,"width":1112,"height":52},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8292ca7a4de7424fb376da3defdc85f5","type":"text","conversion_output":true,"text":"subjects will remain blinded during the extended follow-up phase.","text_display":" subjects will remain blinded during the extended follow-up phase.","confidence":0.998046875,"confidence_rate":0.9999720713209299},{"cnt":[[236,1852],[1154,1852],[1154,1923],[236,1923]],"region":{"top_left_x":236,"top_left_y":1851,"width":918,"height":72},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c079cea3d68e4403b90ef860774e0a82","type":"section_header","conversion_output":false,"children_ids":["ee358f0ce2764af59ca6f55994fc6292","074c752a153d4eb9a6da5926a06eabbf"],"text":"","text_display":""},{"cnt":[[245,1861],[316,1861],[316,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1860,"width":72,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee358f0ce2764af59ca6f55994fc6292","type":"text","conversion_output":true,"parent_id":"c079cea3d68e4403b90ef860774e0a82","text":"5.2","text_display":"\n\n\\section*{5.2","confidence":1,"confidence_rate":1},{"cnt":[[593,1861],[1149,1861],[1149,1919],[593,1919]],"region":{"top_left_x":592,"top_left_y":1860,"width":558,"height":59},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"074c752a153d4eb9a6da5926a06eabbf","type":"text","conversion_output":true,"parent_id":"c079cea3d68e4403b90ef860774e0a82","text":"Discussion of Trial Design","text_display":" Discussion of Trial Design}","confidence":1,"confidence_rate":1},{"cnt":[[241,1946],[627,1946],[627,2013],[241,2013]],"region":{"top_left_x":240,"top_left_y":1946,"width":388,"height":68},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60ecd2a4668c40778f952e9e536afe1b","type":"section_header","conversion_output":false,"children_ids":["447612bdd1fa436dbd667ed3147af8ec"],"text":"","text_display":""},{"cnt":[[245,1955],[621,1955],[621,2007],[245,2007]],"region":{"top_left_x":244,"top_left_y":1955,"width":377,"height":52},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"447612bdd1fa436dbd667ed3147af8ec","type":"text","conversion_output":true,"parent_id":"60ecd2a4668c40778f952e9e536afe1b","text":"Overall Trial Design","text_display":"\n\n\\section*{Overall Trial Design}","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1882,2041],[1882,2095],[245,2095]],"region":{"top_left_x":244,"top_left_y":2041,"width":1639,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49d7764073b44a5690bffb8e1f23f37b","type":"text","conversion_output":true,"text":"The trial will consist of a screening period, a 2 -year DBPC treatment phase, and a 3 -year","text_display":"\n\nThe trial will consist of a screening period, a 2 -year DBPC treatment phase, and a 3 -year","confidence":0.9985356330871582,"confidence_rate":0.9999856330429514},{"cnt":[[245,2093],[694,2093],[694,2144],[245,2144]],"region":{"top_left_x":244,"top_left_y":2092,"width":450,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22f2195b12004191baf02cd4005d1c4a","type":"text","conversion_output":true,"text":"extended follow-up phase.","text_display":" extended follow-up phase.","confidence":1,"confidence_rate":1},{"cnt":[[245,2179],[1882,2179],[1882,2232],[245,2232]],"region":{"top_left_x":244,"top_left_y":2178,"width":1639,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a01a034d16448678e42ef0e885bc82d","type":"text","conversion_output":true,"text":"A screening period of up to 42 days is considered appropriate for assessment of subject","text_display":"\n\nA screening period of up to 42 days is considered appropriate for assessment of subject","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1882,2230],[1882,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1639,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"298e635669f446a78322468c11c72d30","type":"text","conversion_output":true,"text":"eligibility. The screening period will include an assessment of pain levels at screening and","text_display":" eligibility. The screening period will include an assessment of pain levels at screening and","confidence":1,"confidence_rate":1},{"cnt":[[245,2277],[1880,2277],[1880,2327],[245,2327]],"region":{"top_left_x":244,"top_left_y":2277,"width":1636,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71fc57ea557f4e1cb396e03c300252a8","type":"text","conversion_output":true,"text":"baseline prior to randomization. The subject must have a pain score in the target knee of 4 to 9 in","text_display":" baseline prior to randomization. The subject must have a pain score in the target knee of 4 to 9 in","confidence":1,"confidence_rate":1},{"cnt":[[245,2325],[1882,2325],[1882,2376],[245,2376]],"region":{"top_left_x":244,"top_left_y":2324,"width":1639,"height":53},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7ced52d75764a7da50301ad617f72f6","type":"text","conversion_output":true,"text":"response to Question 1 of the WOMAC after a predefined washout period that will be equivalent","text_display":" response to Question 1 of the WOMAC after a predefined washout period that will be equivalent","confidence":1,"confidence_rate":1},{"cnt":[[245,2372],[1811,2372],[1811,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2371,"width":1568,"height":55},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ab79697c946482184dc74d079e49d39","type":"text","conversion_output":true,"text":"to at least 5 half-lives of analgesic medication(s) to be eligible for the study (see Section 5.4).","text_display":" to at least 5 half-lives of analgesic medication(s) to be eligible for the study (see Section 5.4).","confidence":0.99609375,"confidence_rate":0.9999634221706567},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"29e09f508b7741cb97c3c9c2de5723b8","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"344afca25b154045b733aa601c65d242","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaf50938256c4fa495eda47810b64e88","type":"page_info","conversion_output":false,"text":"37/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2610],[1796,2610]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":111},"line":45,"column":0,"font_size":88,"is_printed":true,"is_handwritten":false,"id":"c4f6d1d54fa54662b042390a17ba3d15","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.9921875,"confidence_rate":0.9986936577653456}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-038","page":38,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31c69d6d30d5452c9e3bf68940fd7a60","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a35558fa6c13480a97fbcb43bf069f29","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c4b86dfd93d4e3a9daace55c8e70817","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1884,279],[1884,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1641,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d01c5415d60a4156a6596e2580a818e7","type":"text","conversion_output":true,"text":"The duration of the DBPC treatment phase of the trial will be set at 2 years in order to permit","text_display":"\n\nThe duration of the DBPC treatment phase of the trial will be set at 2 years in order to permit","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1882,329],[1882,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1639,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba7124d2f55d4172a9b3d2307ec73bb4","type":"text","conversion_output":true,"text":"assessment of potential symptomatic and structural benefit. Results of the POC trial suggested","text_display":" assessment of potential symptomatic and structural benefit. Results of the POC trial suggested","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1882,374],[1882,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1639,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84d50a3dbe394e6392c110f57956a8bf","type":"text","conversion_output":true,"text":"that a period longer than 1 year would be necessary to observe treatment benefit on symptoms","text_display":" that a period longer than 1 year would be necessary to observe treatment benefit on symptoms","confidence":0.99853515625,"confidence_rate":0.9999853409306202},{"cnt":[[245,421],[1583,421],[1583,475],[245,475]],"region":{"top_left_x":244,"top_left_y":421,"width":1340,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f4e33d1cf944134826b95d887edd92b","type":"text","conversion_output":true,"text":"relative to placebo resulting from the demonstrated anabolic effect on structure.","text_display":" relative to placebo resulting from the demonstrated anabolic effect on structure.","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1886,511],[1886,565],[245,565]],"region":{"top_left_x":244,"top_left_y":511,"width":1643,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4323bec8ca0747b9a5561827b720b984","type":"text","conversion_output":true,"text":"The extended follow-up phase is intended to permit evaluation of the durability of the effects of","text_display":"\n\nThe extended follow-up phase is intended to permit evaluation of the durability of the effects of","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,561],[438,561],[438,612],[245,612]],"region":{"top_left_x":244,"top_left_y":560,"width":195,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9e541dac4ae4ddb8269c7f677db56b6","type":"text","conversion_output":true,"text":"sprifermin.","text_display":" sprifermin.","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1882,649],[1882,703],[245,703]],"region":{"top_left_x":244,"top_left_y":648,"width":1639,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dd284dd8d504d35aa2826bea2fdb560","type":"text","conversion_output":true,"text":"Sprifermin may be the first drug used in OA to have a disease-modifying action. In the absence","text_display":"\n\nSprifermin may be the first drug used in OA to have a disease-modifying action. In the absence","confidence":0.85595703125,"confidence_rate":0.9984301718426145},{"cnt":[[245,698],[1222,698],[1222,750],[245,750]],"region":{"top_left_x":244,"top_left_y":698,"width":979,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9be5af1de185476296c247cf53f4c5b7","type":"text","conversion_output":true,"text":"of an active comparator, placebo will be used as a control.","text_display":" of an active comparator, placebo will be used as a control.","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[1882,786],[1882,840],[245,840]],"region":{"top_left_x":244,"top_left_y":786,"width":1639,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66bc7ecf052c490fbf210e6add8c3c52","type":"text","conversion_output":true,"text":"A considerable placebo effect on symptoms in OA trials (with an effect size of 0.5 and a duration","text_display":"\n\nA considerable placebo effect on symptoms in OA trials (with an effect size of 0.5 and a duration","confidence":0.9990234375,"confidence_rate":0.9999911978797494},{"cnt":[[245,836],[1882,836],[1882,887],[245,887]],"region":{"top_left_x":244,"top_left_y":835,"width":1639,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41a3cf5e9bca460a9bc769d9b59413bf","type":"text","conversion_output":true,"text":"of 1 year) has been described in the literature (16), and was observed in the POC trial. In this","text_display":" of 1 year) has been described in the literature (16), and was observed in the POC trial. In this","confidence":0.99462890625,"confidence_rate":0.9999482170145101},{"cnt":[[245,883],[1880,883],[1880,935],[245,935]],"region":{"top_left_x":244,"top_left_y":883,"width":1636,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c48a4af019844d51a3d107dc3801ec1e","type":"text","conversion_output":true,"text":"trial, use of pain medication will be controlled to permit greater consistency of pain and function","text_display":" trial, use of pain medication will be controlled to permit greater consistency of pain and function","confidence":1,"confidence_rate":1},{"cnt":[[245,932],[1880,932],[1880,982],[245,982]],"region":{"top_left_x":244,"top_left_y":932,"width":1636,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"691cc41bee854fba901e5d2f9f8b2cf1","type":"text","conversion_output":true,"text":"evaluations and eliminate the confounding effects of concomitant analgesia: subjects will need to","text_display":" evaluations and eliminate the confounding effects of concomitant analgesia: subjects will need to","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,980],[1880,980],[1880,1029],[245,1029]],"region":{"top_left_x":244,"top_left_y":979,"width":1636,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"248b280472fb46399319ad18f719463c","type":"text","conversion_output":true,"text":"refrain from taking analgesics, anti-inflammatory medications, or corticosteroids for \\(\\geq 5\\) half-","text_display":" refrain from taking analgesics, anti-inflammatory medications, or corticosteroids for \\(\\geq 5\\) half","confidence":0.984375,"confidence_rate":0.9998456162618455},{"cnt":[[245,1027],[1880,1027],[1880,1079],[245,1079]],"region":{"top_left_x":244,"top_left_y":1026,"width":1636,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"109486203f7c4440a18aaac1cb1e3098","type":"text","conversion_output":true,"text":"lives before a visit involving completion of the WOMAC. This requirement and the withdrawal","text_display":"lives before a visit involving completion of the WOMAC. This requirement and the withdrawal","confidence":1,"confidence_rate":1},{"cnt":[[245,1074],[1880,1074],[1880,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1074,"width":1636,"height":54},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45577a3501c84ed28afadf5eb0dbbdf4","type":"text","conversion_output":true,"text":"of analgesic medication for 5 half-lives prior to pain assessments is a common practice in clinical","text_display":" of analgesic medication for 5 half-lives prior to pain assessments is a common practice in clinical","confidence":0.9975600242614746,"confidence_rate":0.999977168883715},{"cnt":[[245,1126],[539,1126],[539,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1125,"width":296,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"117e3696dc2d4da88193c99f13a15ff8","type":"text","conversion_output":true,"text":"trials in OA (17).","text_display":" trials in OA (17).","confidence":0.658203125,"confidence_rate":0.9856813733121538},{"cnt":[[236,1210],[599,1210],[599,1270],[236,1270]],"region":{"top_left_x":236,"top_left_y":1209,"width":364,"height":61},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1eb4f772d8543a3b4f3550b7c8254d0","type":"section_header","conversion_output":false,"children_ids":["4e72db6d925f424f9f0f85f1cd6ed799"],"text":"","text_display":""},{"cnt":[[245,1216],[595,1216],[595,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":352,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e72db6d925f424f9f0f85f1cd6ed799","type":"text","conversion_output":true,"parent_id":"f1eb4f772d8543a3b4f3550b7c8254d0","text":"Subject Population","text_display":"\n\n\\section*{Subject Population}","confidence":1,"confidence_rate":1},{"cnt":[[243,1302],[1880,1302],[1880,1354],[243,1354]],"region":{"top_left_x":242,"top_left_y":1301,"width":1638,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c8aefafcba64def823fe3df9805ad57","type":"text","conversion_output":true,"text":"This trial will include symptomatic subjects who have sufficient residual cartilage to respond to","text_display":"\n\nThis trial will include symptomatic subjects who have sufficient residual cartilage to respond to","confidence":1,"confidence_rate":1},{"cnt":[[245,1351],[1880,1351],[1880,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1351,"width":1636,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9065a6d24dad4b87aa205a14fb019d0e","type":"text","conversion_output":true,"text":"sprifermin, and will include better control for external factors such as malalignment than the","text_display":" sprifermin, and will include better control for external factors such as malalignment than the","confidence":0.99853515625,"confidence_rate":0.9999851928603086},{"cnt":[[245,1401],[1880,1401],[1880,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9089dcfed1b24dd19da6c3d446dcc161","type":"text","conversion_output":true,"text":"POC trial. The aim is to select a knee OA population where an improvement in structure may","text_display":" POC trial. The aim is to select a knee OA population where an improvement in structure may","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1448],[1442,1448],[1442,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1448,"width":1198,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a94eedbe5d9d4f7bb3f394fc52ce488a","type":"text","conversion_output":true,"text":"ultimately translate into improvements in symptoms and quality of life.","text_display":" ultimately translate into improvements in symptoms and quality of life.","confidence":1,"confidence_rate":1},{"cnt":[[245,1536],[1880,1536],[1880,1588],[245,1588]],"region":{"top_left_x":244,"top_left_y":1536,"width":1636,"height":52},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e7aff11f2e0462fa19281c2a4a97b4c","type":"text","conversion_output":true,"text":"In the POC trial (Study 28980), an anabolic effect of sprifermin was demonstrated in subjects","text_display":"\n\nIn the POC trial (Study 28980), an anabolic effect of sprifermin was demonstrated in subjects","confidence":1,"confidence_rate":1},{"cnt":[[245,1586],[1880,1586],[1880,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1585,"width":1636,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d733d499e4dd4ec6b16fe128dcc215a9","type":"text","conversion_output":true,"text":"with Kellgren-Lawrence grades (KLG) of 2 or 3, confirming the appropriateness of Kellgren-","text_display":" with Kellgren-Lawrence grades (KLG) of 2 or 3, confirming the appropriateness of Kellgren","confidence":0.9990236759185791,"confidence_rate":0.9999900326925697},{"cnt":[[245,1633],[930,1633],[930,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1632,"width":687,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f5eec912e9b40cbb2500e67a4883553","type":"text","conversion_output":true,"text":"Lawrence grades as a selection criterion.","text_display":"Lawrence grades as a selection criterion.","confidence":1,"confidence_rate":1},{"cnt":[[245,1723],[1880,1723],[1880,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1723,"width":1636,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aaf5f5bf73954adbadd6ad228e99b100","type":"text","conversion_output":true,"text":"However, in the POC trial, no minimal JSW was specified. The average JSW in the POC trial","text_display":"\n\nHowever, in the POC trial, no minimal JSW was specified. The average JSW in the POC trial","confidence":1,"confidence_rate":1},{"cnt":[[245,1770],[1880,1770],[1880,1820],[245,1820]],"region":{"top_left_x":244,"top_left_y":1770,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"481e549a2d3849858b24ab4b8f9b0a3f","type":"text","conversion_output":true,"text":"was approximately 3.5 mm and the minimum JSW was 0.2 mm . The requirement of JSW of at","text_display":" was approximately 3.5 mm and the minimum JSW was 0.2 mm . The requirement of JSW of at","confidence":1,"confidence_rate":1},{"cnt":[[245,1818],[1880,1818],[1880,1867],[245,1867]],"region":{"top_left_x":244,"top_left_y":1817,"width":1636,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7036aab7a3584718adb5d7546c83f206","type":"text","conversion_output":true,"text":"least 2.5 mm in the medial compartment in this trial will lead to the inclusion of patients with","text_display":" least 2.5 mm in the medial compartment in this trial will lead to the inclusion of patients with","confidence":1,"confidence_rate":1},{"cnt":[[245,1865],[1882,1865],[1882,1916],[245,1916]],"region":{"top_left_x":244,"top_left_y":1864,"width":1639,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b32328782c194f0ab9c998b2d60e67cb","type":"text","conversion_output":true,"text":"sufficient remaining interbone distance (i.e., a higher average JSW) that will thus permit","text_display":" sufficient remaining interbone distance (i.e., a higher average JSW) that will thus permit","confidence":0.97998046875,"confidence_rate":0.999787152788203},{"cnt":[[245,1914],[1605,1914],[1605,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1914,"width":1361,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e3ee9c5ef0f4e319541f1328e0128a1","type":"text","conversion_output":true,"text":"demonstration of either progression (worsening) or improvement during the trial.","text_display":" demonstration of either progression (worsening) or improvement during the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,2002],[1880,2002],[1880,2054],[245,2054]],"region":{"top_left_x":244,"top_left_y":2002,"width":1636,"height":52},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bf4095353fd487fa0c2c0cb827d15df","type":"text","conversion_output":true,"text":"Malalignment will be limited to 5 degrees in order to limit confounding factors regarding","text_display":"\n\nMalalignment will be limited to 5 degrees in order to limit confounding factors regarding","confidence":0.9990234375,"confidence_rate":0.9999899274770393},{"cnt":[[245,2050],[642,2050],[642,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2049,"width":399,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be870e74472840f29879086a06387f28","type":"text","conversion_output":true,"text":"biomechanical loading.","text_display":" biomechanical loading.","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1880,2140],[1880,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2139,"width":1636,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05a6ebc00a2b4c69947c35dd0821be4d","type":"text","conversion_output":true,"text":"Women of childbearing potential will be allowed to participate in the trial, provided they adhere","text_display":"\n\nWomen of childbearing potential will be allowed to participate in the trial, provided they adhere","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,2189],[1188,2189],[1188,2241],[245,2241]],"region":{"top_left_x":244,"top_left_y":2189,"width":945,"height":52},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02dc9cccbd254e1f8972dcf50d28026d","type":"text","conversion_output":true,"text":"to the use of a highly effective method of contraception.","text_display":" to the use of a highly effective method of contraception.","confidence":1,"confidence_rate":1},{"cnt":[[241,2277],[685,2277],[685,2333],[241,2333]],"region":{"top_left_x":240,"top_left_y":2277,"width":446,"height":57},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"599208e568594bec93209c32b5cecc72","type":"section_header","conversion_output":false,"children_ids":["926d243ed40d42a69235cae9bc83ac14"],"text":"","text_display":""},{"cnt":[[245,2282],[681,2282],[681,2327],[245,2327]],"region":{"top_left_x":244,"top_left_y":2281,"width":438,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"926d243ed40d42a69235cae9bc83ac14","type":"text","conversion_output":true,"parent_id":"599208e568594bec93209c32b5cecc72","text":"Dose and Dose Regimen","text_display":"\n\n\\section*{Dose and Dose Regimen}","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1880,2368],[1880,2419],[245,2419]],"region":{"top_left_x":244,"top_left_y":2367,"width":1636,"height":53},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11841f6ea0ea48f8bfac216b7f989e4d","type":"text","conversion_output":true,"text":"The aim of this trial is to optimize the dose and the dosing interval for sprifermin and to find a","text_display":"\n\nThe aim of this trial is to optimize the dose and the dosing interval for sprifermin and to find a","confidence":1,"confidence_rate":1},{"cnt":[[245,2415],[1124,2415],[1124,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2414,"width":880,"height":55},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c8c9f5808aa44408e063e30741f4482","type":"text","conversion_output":true,"text":"balance between effects on symptoms and structure.","text_display":" balance between effects on symptoms and structure.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"33013dd707414c3db2f0a669b013a9f0","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":42},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"99da5e36be11493c8aaf1390dbbe81e4","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de4d976338d649e8867fd30e15e5b168","type":"page_info","conversion_output":false,"text":"38/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-039","page":39,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9618dee0cb843abbfb07c97ca816a3d","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e858bc9894a4a069ed31a399ec37c62","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3600636bdab1444f8e55e798df0afb3d","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1884,279],[1884,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1641,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6909edad32624e898761d4144ce20074","type":"text","conversion_output":true,"text":"OA is a chronic disease, and therefore treatment will most likely need to be repeated at regular","text_display":"\n\nOA is a chronic disease, and therefore treatment will most likely need to be repeated at regular","confidence":0.5995116233825684,"confidence_rate":0.9949470674862043},{"cnt":[[245,329],[406,329],[406,372],[245,372]],"region":{"top_left_x":244,"top_left_y":328,"width":163,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe33b25bbef147da83415382079cb3b2","type":"text","conversion_output":true,"text":"intervals.","text_display":" intervals.","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1880,417],[1880,468],[245,468]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c4f5f36f9e146c193aa48e8e6da75c8","type":"text","conversion_output":true,"text":"The use of repeated cycles of 3 once-weekly injections over 3 consecutive weeks is based on","text_display":"\n\nThe use of repeated cycles of 3 once-weekly injections over 3 consecutive weeks is based on","confidence":0.998046875,"confidence_rate":0.9999808331754918},{"cnt":[[243,466],[1880,466],[1880,518],[243,518]],"region":{"top_left_x":242,"top_left_y":466,"width":1638,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce9b7520b491458f8f69322790884667","type":"text","conversion_output":true,"text":"preclinical data generated in the dog meniscectomy model (see the sprifermin IB), which","text_display":" preclinical data generated in the dog meniscectomy model (see the sprifermin IB), which","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1884,516],[1884,565],[245,565]],"region":{"top_left_x":244,"top_left_y":515,"width":1641,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7183b3265d1b48a68ab8ee7abac479fa","type":"text","conversion_output":true,"text":"suggested that anabolic effects on cartilage tissue were more pronounced when a given dose of","text_display":" suggested that anabolic effects on cartilage tissue were more pronounced when a given dose of","confidence":1,"confidence_rate":1},{"cnt":[[245,561],[1882,561],[1882,612],[245,612]],"region":{"top_left_x":244,"top_left_y":560,"width":1639,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6cb2887ceae40a1bb56b81735e61537","type":"text","conversion_output":true,"text":"sprifermin was administered as three i.a. injections than when it was administered as a single","text_display":" sprifermin was administered as three i.a. injections than when it was administered as a single","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[410,610],[410,660],[245,660]],"region":{"top_left_x":244,"top_left_y":610,"width":167,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc201e3a7d304288bb5c44dbc1304ad6","type":"text","conversion_output":true,"text":"injection.","text_display":" injection.","confidence":1,"confidence_rate":1},{"cnt":[[245,698],[1880,698],[1880,750],[245,750]],"region":{"top_left_x":244,"top_left_y":698,"width":1636,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9725e774cb56400bb64df023e0469b18","type":"text","conversion_output":true,"text":"In this trial, 2 dosage strengths of sprifermin ( 30 and 100 mcg ) and 2 regimens ( 4 treatment","text_display":"\n\nIn this trial, 2 dosage strengths of sprifermin ( 30 and 100 mcg ) and 2 regimens ( 4 treatment","confidence":0.9404296875,"confidence_rate":0.9994751942219887},{"cnt":[[245,748],[1880,748],[1880,797],[245,797]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0ebc5d68803439c849b3f21962fcd9a","type":"text","conversion_output":true,"text":"cycles given at 6 -month intervals and 2 treatment cycles given at a 12 -month interval) will be","text_display":" cycles given at 6 -month intervals and 2 treatment cycles given at a 12 -month interval) will be","confidence":0.9907509953584395,"confidence_rate":0.9999155304562926},{"cnt":[[245,795],[1536,795],[1536,846],[245,846]],"region":{"top_left_x":244,"top_left_y":794,"width":1293,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bf2966ad6f74380b20be952c916daff","type":"text","conversion_output":true,"text":"used in this trial. Each regimen of sprifermin will be compared with placebo.","text_display":" used in this trial. Each regimen of sprifermin will be compared with placebo.","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1880,885],[1880,935],[245,935]],"region":{"top_left_x":244,"top_left_y":885,"width":1636,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a771a159ba4444bba924ca62e3e9941","type":"text","conversion_output":true,"text":"The 10 mcg dosage of sprifermin used in the POC trial will not be used in this trial: despite","text_display":"\n\nThe 10 mcg dosage of sprifermin used in the POC trial will not be used in this trial: despite","confidence":0.998046875,"confidence_rate":0.9999810192594005},{"cnt":[[245,932],[1880,932],[1880,982],[245,982]],"region":{"top_left_x":244,"top_left_y":932,"width":1636,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd948f3ab3364120928b25da543a7eff","type":"text","conversion_output":true,"text":"observation of some biological effect, there was limited effect on MRI or clinical outcomes with","text_display":" observation of some biological effect, there was limited effect on MRI or clinical outcomes with","confidence":1,"confidence_rate":1},{"cnt":[[245,980],[1880,980],[1880,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":979,"width":1636,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55ff7f2c65bf46e0885282e24661ecce","type":"text","conversion_output":true,"text":"this dose. Furthermore, results from the POC trial suggested that an interval of 3 months between","text_display":" this dose. Furthermore, results from the POC trial suggested that an interval of 3 months between","confidence":1,"confidence_rate":1},{"cnt":[[245,1027],[784,1027],[784,1079],[245,1079]],"region":{"top_left_x":244,"top_left_y":1026,"width":541,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83c38f69aec54cf3aa71e42fc100f0d8","type":"text","conversion_output":true,"text":"cycles may have been too short.","text_display":" cycles may have been too short.","confidence":1,"confidence_rate":1},{"cnt":[[243,1117],[578,1117],[578,1167],[243,1167]],"region":{"top_left_x":242,"top_left_y":1117,"width":336,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ad8563ca352417481d4da56c7436944","type":"section_header","conversion_output":false,"children_ids":["ff24da809eca4edfb6495f3d4c519c84"],"text":"","text_display":""},{"cnt":[[245,1121],[574,1121],[574,1162],[245,1162]],"region":{"top_left_x":244,"top_left_y":1121,"width":330,"height":42},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff24da809eca4edfb6495f3d4c519c84","type":"text","conversion_output":true,"parent_id":"2ad8563ca352417481d4da56c7436944","text":"Trial Assessments","text_display":"\n\n\\section*{Trial Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[241,1203],[1476,1203],[1476,1263],[241,1263]],"region":{"top_left_x":240,"top_left_y":1203,"width":1236,"height":61},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92d679f3d7ed4ec4a7b738b0a326c26c","type":"section_header","conversion_output":false,"children_ids":["a0b194bc556e40aa90406464724d3619"],"text":"","text_display":""},{"cnt":[[245,1207],[1472,1207],[1472,1257],[245,1257]],"region":{"top_left_x":244,"top_left_y":1207,"width":1228,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0b194bc556e40aa90406464724d3619","type":"text","conversion_output":true,"parent_id":"92d679f3d7ed4ec4a7b738b0a326c26c","text":"Evaluation of Structure by MRI and Choice of MRI as Primary Endpoint","text_display":"\n\n\\section*{Evaluation of Structure by MRI and Choice of MRI as Primary Endpoint}","confidence":1,"confidence_rate":1},{"cnt":[[245,1298],[1880,1298],[1880,1347],[245,1347]],"region":{"top_left_x":244,"top_left_y":1297,"width":1636,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a19c1e8e19240c08a75b7ed555b8453","type":"text","conversion_output":true,"text":"Conventional radiography can visualize dense structures such as cortical and trabecular bone;","text_display":"\n\nConventional radiography can visualize dense structures such as cortical and trabecular bone;","confidence":1,"confidence_rate":1},{"cnt":[[245,1345],[1880,1345],[1880,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1344,"width":1636,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdc4c385459545bc861342748a751a26","type":"text","conversion_output":true,"text":"however, other components of the human knee such as cartilage, menisci, ligaments, synovium,","text_display":" however, other components of the human knee such as cartilage, menisci, ligaments, synovium,","confidence":1,"confidence_rate":1},{"cnt":[[245,1394],[1880,1394],[1880,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1394,"width":1636,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a492a0ad7b9f4b9ea1d63beba7e2cb80","type":"text","conversion_output":true,"text":"synovial fluid, and pathological alterations of bony structures such as cysts and edema can only","text_display":" synovial fluid, and pathological alterations of bony structures such as cysts and edema can only","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1880,1439],[1880,1491],[245,1491]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1acd39fc355f44c68a14b6bf7d3d76bd","type":"text","conversion_output":true,"text":"be visualized with MRI (18). In recent years, MRI has been shown to have high inter-observer","text_display":" be visualized with MRI (18). In recent years, MRI has been shown to have high inter-observer","confidence":1,"confidence_rate":1},{"cnt":[[245,1489],[1884,1489],[1884,1540],[245,1540]],"region":{"top_left_x":244,"top_left_y":1488,"width":1641,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4ef9eeee61e469482688d4844716e95","type":"text","conversion_output":true,"text":"agreement among trained radiologists and to have a high internal validity in the assessment of","text_display":" agreement among trained radiologists and to have a high internal validity in the assessment of","confidence":1,"confidence_rate":1},{"cnt":[[245,1538],[1884,1538],[1884,1588],[245,1588]],"region":{"top_left_x":244,"top_left_y":1538,"width":1641,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec478137d19944b7b1f66e1653b0ca21","type":"text","conversion_output":true,"text":"OA through its ability to define soft-tissue structures with high precision. Thus, a comparison of","text_display":" OA through its ability to define soft-tissue structures with high precision. Thus, a comparison of","confidence":1,"confidence_rate":1},{"cnt":[[245,1586],[1884,1586],[1884,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1585,"width":1641,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59792eac1f574e7287557ed0cfb4dff4","type":"text","conversion_output":true,"text":"MRI scans with conventional X-rays revealed that joint space narrowing was more due to loss of","text_display":" MRI scans with conventional X-rays revealed that joint space narrowing was more due to loss of","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1633],[1291,1633],[1291,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1632,"width":1048,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"154a656f391f42339f345ec5a4f50fdd","type":"text","conversion_output":true,"text":"meniscal structure than loss of hyaline cartilage structure (19).","text_display":" meniscal structure than loss of hyaline cartilage structure (19).","confidence":0.98828125,"confidence_rate":0.9998316148104913},{"cnt":[[245,1723],[1880,1723],[1880,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1723,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9497fa4afe64f6eab68ef4777d6c3f1","type":"text","conversion_output":true,"text":"Change from baseline in cartilage thickness in the total femorotibial joint at 2 years as evaluated","text_display":"\n\nChange from baseline in cartilage thickness in the total femorotibial joint at 2 years as evaluated","confidence":1,"confidence_rate":1},{"cnt":[[245,1770],[1880,1770],[1880,1824],[245,1824]],"region":{"top_left_x":244,"top_left_y":1770,"width":1636,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"462bc438b7124f28b1fea20edfe2fc44","type":"text","conversion_output":true,"text":"by MRI has been chosen as primary endpoint for this trial because this parameter is thought to be","text_display":" by MRI has been chosen as primary endpoint for this trial because this parameter is thought to be","confidence":1,"confidence_rate":1},{"cnt":[[245,1818],[1631,1818],[1631,1869],[245,1869]],"region":{"top_left_x":244,"top_left_y":1817,"width":1387,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"991c35e665ce47eb93d8ed251b4c4071","type":"text","conversion_output":true,"text":"most appropriate for demonstrating reversal of the degeneration of cartilage tissue.","text_display":" most appropriate for demonstrating reversal of the degeneration of cartilage tissue.","confidence":1,"confidence_rate":1},{"cnt":[[245,1908],[1880,1908],[1880,1957],[245,1957]],"region":{"top_left_x":244,"top_left_y":1907,"width":1636,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d1a6474c9fe4066b95d8f6692e87b7d","type":"text","conversion_output":true,"text":"Change in total cartilage volume may be less sensitive than change in thickness, as it may not","text_display":"\n\nChange in total cartilage volume may be less sensitive than change in thickness, as it may not","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1955],[1807,1955],[1807,2007],[245,2007]],"region":{"top_left_x":244,"top_left_y":1955,"width":1563,"height":52},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8637902d07964c3284e0f3f12553313f","type":"text","conversion_output":true,"text":"reflect growth of cartilage in regions of the knee that have importance in mechanical loading.","text_display":" reflect growth of cartilage in regions of the knee that have importance in mechanical loading.","confidence":1,"confidence_rate":1},{"cnt":[[245,2045],[1880,2045],[1880,2095],[245,2095]],"region":{"top_left_x":244,"top_left_y":2045,"width":1636,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e30e6c1dc16d4d349b41242181586458","type":"text","conversion_output":true,"text":"Because sprifermin has been shown to exert a structure-modifying effect, it appears imperative to","text_display":"\n\nBecause sprifermin has been shown to exert a structure-modifying effect, it appears imperative to","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1880,2093],[1880,2144],[245,2144]],"region":{"top_left_x":244,"top_left_y":2092,"width":1636,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2390d0f71282400aba6b1d39f5b86f5e","type":"text","conversion_output":true,"text":"use MRI data (specifically change in thickness) to either confirm or disprove this effect on","text_display":" use MRI data (specifically change in thickness) to either confirm or disprove this effect on","confidence":0.9990236759185791,"confidence_rate":0.9999899299373404},{"cnt":[[245,2140],[561,2140],[561,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2139,"width":317,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"794597e100944c2fb99b50982377b499","type":"text","conversion_output":true,"text":"cartilage structure.","text_display":" cartilage structure.","confidence":1,"confidence_rate":1},{"cnt":[[241,2226],[672,2226],[672,2288],[241,2288]],"region":{"top_left_x":240,"top_left_y":2225,"width":433,"height":64},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8013b79fd9ed40eaa1685779cad70781","type":"section_header","conversion_output":false,"children_ids":["d0c327b248d544289510c208c104239b"],"text":"","text_display":""},{"cnt":[[245,2230],[668,2230],[668,2282],[245,2282]],"region":{"top_left_x":244,"top_left_y":2230,"width":425,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0c327b248d544289510c208c104239b","type":"text","conversion_output":true,"parent_id":"8013b79fd9ed40eaa1685779cad70781","text":"Evaluation of Symptoms","text_display":"\n\n\\section*{Evaluation of Symptoms}","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1880,2320],[1880,2370],[245,2370]],"region":{"top_left_x":244,"top_left_y":2320,"width":1636,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40df2b6de28c461e9a1a29b8b076b733","type":"text","conversion_output":true,"text":"The WOMAC is a validated instrument used to assess symptom modification in clinical OA","text_display":"\n\nThe WOMAC is a validated instrument used to assess symptom modification in clinical OA","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1880,2368],[1880,2419],[245,2419]],"region":{"top_left_x":244,"top_left_y":2367,"width":1636,"height":53},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b644b4e49f4d40ebb0a01b1109d1be30","type":"text","conversion_output":true,"text":"trials. This clinical score was developed in 1981 and is regarded as a valid instrument by both","text_display":" trials. This clinical score was developed in 1981 and is regarded as a valid instrument by both","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ecbde54bc92746f29b2c7a4744d21323","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f4afaa2806964c89abad70b485331196","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2787db8ea17b4d26b412b9912dcbe0f3","type":"page_info","conversion_output":false,"text":"39/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1794,2501],[1904,2501],[1904,2608],[1794,2608]],"region":{"top_left_x":1793,"top_left_y":2500,"width":111,"height":109},"line":45,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"54ad1f202f0c4bc9a456c231357bf2ca","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999186032298787}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-040","page":40,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4764d9ad73bb416e9cc66612b039d0d2","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c179aaf8bae74f1e887b1bbac73c1116","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"308c2abb2ad143be9fc1627ea2645aaf","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1884,279],[1884,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1641,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5a04aba4a4449b7955ad7e346d6ff54","type":"text","conversion_output":true,"text":"clinical researchers and regulatory authorities (20). The WOMAC questionnaire is further","text_display":"\nclinical researchers and regulatory authorities (20). The WOMAC questionnaire is further","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,329],[696,329],[696,376],[245,376]],"region":{"top_left_x":244,"top_left_y":328,"width":453,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d67efc6782714ff9ab59330c37af1c29","type":"text","conversion_output":true,"text":"described in Section 7.3.2.","text_display":" described in Section 7.3.2.","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1880,417],[1880,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02934680c9ca406397fc03dba5703d0c","type":"text","conversion_output":true,"text":"Considering that sprifermin has been shown to exert an anabolic effect on cartilage matrix, i.e.,","text_display":"\n\nConsidering that sprifermin has been shown to exert an anabolic effect on cartilage matrix, i.e.,","confidence":0.99658203125,"confidence_rate":0.999966433667778},{"cnt":[[243,466],[1880,466],[1880,518],[243,518]],"region":{"top_left_x":242,"top_left_y":466,"width":1638,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d00f1493e2304a5ba5647039255ea9a6","type":"text","conversion_output":true,"text":"that it has a structure-modifying effect, it is expected that if it also has a symptom-modifying","text_display":" that it has a structure-modifying effect, it is expected that if it also has a symptom-modifying","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1880,516],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0506e2481cb478ea81c927a4414c419","type":"text","conversion_output":true,"text":"effect, this will become more evident in terms of the functional aspect of the WOMAC compared","text_display":" effect, this will become more evident in terms of the functional aspect of the WOMAC compared","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[885,563],[885,612],[245,612]],"region":{"top_left_x":244,"top_left_y":562,"width":642,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8326e381fa7942efa9ffcaa6875298ea","type":"text","conversion_output":true,"text":"to those addressing pain and stiffness.","text_display":" to those addressing pain and stiffness.","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1880,649],[1880,703],[245,703]],"region":{"top_left_x":244,"top_left_y":648,"width":1636,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fec67fdfd464532b1591d85a16b2e75","type":"text","conversion_output":true,"text":"The 20 -meter walk test will be used to provide an objective evaluation of the subject's physical","text_display":"\n\nThe 20 -meter walk test will be used to provide an objective evaluation of the subject's physical","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,700],[1880,700],[1880,750],[245,750]],"region":{"top_left_x":244,"top_left_y":700,"width":1636,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a219f867169d44df9f2b17bb73519b85","type":"text","conversion_output":true,"text":"functioning, to complement the results of the (subject-assessed) WOMAC function index score.","text_display":" functioning, to complement the results of the (subject-assessed) WOMAC function index score.","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[1880,748],[1880,797],[245,797]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e3211677b3c49cc81457d0e278fc175","type":"text","conversion_output":true,"text":"This test consists of measuring the time needed for the subject to walk 20 meters at a normal","text_display":" This test consists of measuring the time needed for the subject to walk 20 meters at a normal","confidence":1,"confidence_rate":1},{"cnt":[[245,801],[337,801],[337,844],[245,844]],"region":{"top_left_x":244,"top_left_y":801,"width":94,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"206d23a6bf704c9abadeadd5bec57fa3","type":"text","conversion_output":true,"text":"pace.","text_display":" pace.","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1882,885],[1882,935],[245,935]],"region":{"top_left_x":244,"top_left_y":885,"width":1639,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12edd4c78a11447f9819f76058d323ae","type":"text","conversion_output":true,"text":"In addition to the WOMAC, multiple questionnaires will be used to explore the treatment effect","text_display":"\n\nIn addition to the WOMAC, multiple questionnaires will be used to explore the treatment effect","confidence":1,"confidence_rate":1},{"cnt":[[245,932],[1880,932],[1880,982],[245,982]],"region":{"top_left_x":244,"top_left_y":932,"width":1636,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b972366ac0b44148ad786ab6aff71a65","type":"text","conversion_output":true,"text":"on the symptoms associated with OA. The Symptom Index subscale of the KOOS, a knee-","text_display":" on the symptoms associated with OA. The Symptom Index subscale of the KOOS, a knee","confidence":0.9990234375,"confidence_rate":0.9999888973383643},{"cnt":[[245,980],[1880,980],[1880,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":979,"width":1636,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8f09a3e841f45d09253e5d0b1533042","type":"text","conversion_output":true,"text":"specific questionnaire described in Section 7.7.1, will be used to assess symptoms associated","text_display":"specific questionnaire described in Section 7.7.1, will be used to assess symptoms associated","confidence":1,"confidence_rate":1},{"cnt":[[245,1027],[1880,1027],[1880,1079],[245,1079]],"region":{"top_left_x":244,"top_left_y":1026,"width":1636,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44005e61adbb4428a1bde2bcce4f0f04","type":"text","conversion_output":true,"text":"with tibiofemoral cartilage loss. Pain, a major component of OA, will additionally be assessed","text_display":" with tibiofemoral cartilage loss. Pain, a major component of OA, will additionally be assessed","confidence":1,"confidence_rate":1},{"cnt":[[245,1076],[1880,1076],[1880,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1076,"width":1636,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b4fca2e69ac4f85ae0e84e593638523","type":"text","conversion_output":true,"text":"using an 11 -point NRS, evaluating the worst knee pain in the past 24 hours (Section 7.7.5). In","text_display":" using an 11 -point NRS, evaluating the worst knee pain in the past 24 hours (Section 7.7.5). In","confidence":0.96484375,"confidence_rate":0.999662423898699},{"cnt":[[245,1126],[1880,1126],[1880,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1125,"width":1636,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53cd2c3c58d545d0bd4a581491088805","type":"text","conversion_output":true,"text":"addition, the ICOAP questionnaire will be used to explore the effect of treatment on intermittent","text_display":" addition, the ICOAP questionnaire will be used to explore the effect of treatment on intermittent","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,1173],[1880,1173],[1880,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1636,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e9d686b077c40afb7350b86d09c93c5","type":"text","conversion_output":true,"text":"and continuous OA pain (Section 7.7.3). Both of these assessments will complement the","text_display":" and continuous OA pain (Section 7.7.3). Both of these assessments will complement the","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[711,1220],[711,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1220,"width":468,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc7b2cfcfc8d4fd79ea228a263f1b9f6","type":"text","conversion_output":true,"text":"WOMAC pain index score.","text_display":" WOMAC pain index score.","confidence":1,"confidence_rate":1},{"cnt":[[245,1308],[1884,1308],[1884,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1308,"width":1641,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"290e0bf343b34f629134cd26888a8627","type":"text","conversion_output":true,"text":"Pain in other joints may be a confounding variable in the assessment of self-reported activities of","text_display":"\n\nPain in other joints may be a confounding variable in the assessment of self-reported activities of","confidence":0.99365234375,"confidence_rate":0.9999387721794735},{"cnt":[[245,1358],[1880,1358],[1880,1407],[245,1407]],"region":{"top_left_x":244,"top_left_y":1357,"width":1636,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"314b6c1e847b4950a3556cd6feee1a9c","type":"text","conversion_output":true,"text":"daily living (WOMAC ADL), performance on the 20 -meter walk test, and overall health-related","text_display":" daily living (WOMAC ADL), performance on the 20 -meter walk test, and overall health-related","confidence":1,"confidence_rate":1},{"cnt":[[245,1405],[1880,1405],[1880,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2bcf870e8204abbafb20e16dd84538d","type":"text","conversion_output":true,"text":"quality of life (MOS SF-36). Pain in other joints may also serve as indicator of overall OA","text_display":" quality of life (MOS SF-36). Pain in other joints may also serve as indicator of overall OA","confidence":1,"confidence_rate":1},{"cnt":[[245,1452],[1880,1452],[1880,1504],[245,1504]],"region":{"top_left_x":244,"top_left_y":1452,"width":1636,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3eb1be156e86414cb2aa2e131739616c","type":"text","conversion_output":true,"text":"progression. Pain in the non-target knee will be assessed using the same 11-point NRS used in","text_display":" progression. Pain in the non-target knee will be assessed using the same 11-point NRS used in","confidence":0.998046875,"confidence_rate":0.9999800508639274},{"cnt":[[245,1500],[1880,1500],[1880,1553],[245,1553]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0514ef3a96dd4eb5877dfd768bef9f22","type":"text","conversion_output":true,"text":"the target knee. In addition, pain in joints other than the knees will be identified using a scale","text_display":" the target knee. In addition, pain in joints other than the knees will be identified using a scale","confidence":1,"confidence_rate":1},{"cnt":[[245,1551],[1175,1551],[1175,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1551,"width":932,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17fec8321e4342749b679ffc0582755e","type":"text","conversion_output":true,"text":"model of the human body (homunculus; Section 7.7.6).","text_display":" model of the human body (homunculus; Section 7.7.6).","confidence":1,"confidence_rate":1},{"cnt":[[245,1639],[1880,1639],[1880,1691],[245,1691]],"region":{"top_left_x":244,"top_left_y":1639,"width":1636,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d37debfa0b14de3aaee2589538996ac","type":"text","conversion_output":true,"text":"The PGA and PGIC will be used to capture the subject's global impression of their target knee","text_display":"\n\nThe PGA and PGIC will be used to capture the subject's global impression of their target knee","confidence":1,"confidence_rate":1},{"cnt":[[245,1687],[1880,1687],[1880,1738],[245,1738]],"region":{"top_left_x":244,"top_left_y":1686,"width":1636,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dda213f24df44cdb8e075eec4a3b2961","type":"text","conversion_output":true,"text":"pain and measure global improvement with treatment relative to baseline symptoms. As","text_display":" pain and measure global improvement with treatment relative to baseline symptoms. As","confidence":1,"confidence_rate":1},{"cnt":[[245,1732],[1884,1732],[1884,1785],[245,1785]],"region":{"top_left_x":244,"top_left_y":1731,"width":1641,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61d4b5445a2545ceb3f10e20e8587fe4","type":"text","conversion_output":true,"text":"described in Sections 7.7.3 and 7.7.4, these are responsive and readily interpretable measures of","text_display":" described in Sections 7.7.3 and 7.7.4, these are responsive and readily interpretable measures of","confidence":1,"confidence_rate":1},{"cnt":[[245,1783],[1880,1783],[1880,1833],[245,1833]],"region":{"top_left_x":244,"top_left_y":1783,"width":1636,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e9eb648d06d4f19938b4276c8f16745","type":"text","conversion_output":true,"text":"participant's assessments of the clinical importance of their improvement or worsening over the","text_display":" participant's assessments of the clinical importance of their improvement or worsening over the","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[690,1830],[690,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1830,"width":446,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e71473dd7b14bb2aad84778c836497e","type":"text","conversion_output":true,"text":"course of the clinical trial.","text_display":" course of the clinical trial.","confidence":1,"confidence_rate":1},{"cnt":[[241,1916],[737,1916],[737,1979],[241,1979]],"region":{"top_left_x":240,"top_left_y":1916,"width":497,"height":63},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82d27210bed44834a99b81819650c714","type":"section_header","conversion_output":false,"children_ids":["8aae669f2f6345b18e2247538efa458d"],"text":"","text_display":""},{"cnt":[[245,1921],[733,1921],[733,1972],[245,1972]],"region":{"top_left_x":244,"top_left_y":1920,"width":489,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8aae669f2f6345b18e2247538efa458d","type":"text","conversion_output":true,"parent_id":"82d27210bed44834a99b81819650c714","text":"Evaluation of JSW by X-ray","text_display":"\n\n\\section*{Evaluation of JSW by X-ray}","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1880,2007],[1880,2060],[245,2060]],"region":{"top_left_x":244,"top_left_y":2006,"width":1636,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"736f95f27d464ec9a13401bfa66796ab","type":"text","conversion_output":true,"text":"Change in joint space narrowing will be visualized with the \"fixed flexion\" knee radiograph","text_display":"\n\nChange in joint space narrowing will be visualized with the \"fixed flexion\" knee radiograph","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[814,2058],[814,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":571,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c3e8d8345d54087a2f166d8f687c3a2","type":"text","conversion_output":true,"text":"protocol ((21); see Section 7.3.4).","text_display":" protocol ((21); see Section 7.3.4).","confidence":1,"confidence_rate":1},{"cnt":[[245,2148],[1880,2148],[1880,2198],[245,2198]],"region":{"top_left_x":244,"top_left_y":2148,"width":1636,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"011ae5b3c4d746448a7b13c7b6d34b6c","type":"text","conversion_output":true,"text":"Among rheumatologists, determination of joint space narrowing by X-ray is considered to be a","text_display":"\n\nAmong rheumatologists, determination of joint space narrowing by X-ray is considered to be a","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,2196],[1882,2196],[1882,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2195,"width":1639,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43e43c601b494850bd49f9bd00b971ce","type":"text","conversion_output":true,"text":"semi-quantitative method for assessment of progression of knee OA. This outcome is recognized","text_display":" semi-quantitative method for assessment of progression of knee OA. This outcome is recognized","confidence":0.998046875,"confidence_rate":0.9999800508639274},{"cnt":[[245,2243],[1371,2243],[1371,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2242,"width":1127,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d431960d6524824a3df2624b3c85952","type":"text","conversion_output":true,"text":"as valid by regulatory authorities in Europe and the USA (20),(22).","text_display":" as valid by regulatory authorities in Europe and the USA (20),(22).","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d367a21cd37b4a81b5fc131d1f744d69","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2544],[390,2587],[245,2589]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":46},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fcd25632437440439eaa9a46625d6989","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2af13af33c7d47ef8f29fa21a34e79da","type":"page_info","conversion_output":false,"text":"40/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2610],[1796,2610]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":111},"line":43,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"40707bda7faf4818b48c88ccf342f81c","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.9990234375,"confidence_rate":0.9998371733163992}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-041","page":41,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d099a8a297124721a3b8fe5e2f74b47c","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f2430d2802a41ccb94008f69f3e3cc2","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7695b301ff424fc9ae1e812ba5c464f0","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[604,275],[604,335],[241,335]],"region":{"top_left_x":240,"top_left_y":275,"width":364,"height":61},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d108683765d486a9b230796f3ace63c","type":"section_header","conversion_output":false,"children_ids":["de76a8a3f989456db11bad66146fae53"],"text":"","text_display":""},{"cnt":[[245,279],[599,279],[599,329],[245,329]],"region":{"top_left_x":244,"top_left_y":279,"width":356,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de76a8a3f989456db11bad66146fae53","type":"text","conversion_output":true,"parent_id":"4d108683765d486a9b230796f3ace63c","text":"Evaluation of Safety","text_display":"\n\n\\section*{Evaluation of Safety}","confidence":1,"confidence_rate":1},{"cnt":[[245,370],[1882,370],[1882,421],[245,421]],"region":{"top_left_x":244,"top_left_y":369,"width":1639,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d86db9108034fbd8b42b2d5420a6aff","type":"text","conversion_output":true,"text":"AE monitoring, safety laboratory measurements, measurement of vital signs, weight, physical","text_display":"\n\nAE monitoring, safety laboratory measurements, measurement of vital signs, weight, physical","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1884,417],[1884,468],[245,468]],"region":{"top_left_x":244,"top_left_y":416,"width":1641,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bb80533b7854ff484c3abad93f8b49e","type":"text","conversion_output":true,"text":"examinations, ECGs, incidence of surgery, and, in case of a non-systemic drug, assessment of","text_display":" examinations, ECGs, incidence of surgery, and, in case of a non-systemic drug, assessment of","confidence":1,"confidence_rate":1},{"cnt":[[245,466],[1880,466],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1636,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9acbc611a92d474a9b665b7efbeb0785","type":"text","conversion_output":true,"text":"local tolerability are standard measures to evaluate the safety profile of an investigational","text_display":" local tolerability are standard measures to evaluate the safety profile of an investigational","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1880,511],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":511,"width":1636,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0ce1dd68c1d4756af44457fcb868d80","type":"text","conversion_output":true,"text":"product. Safety endpoints to be assessed in this trial are consistent with those used in previous","text_display":" product. Safety endpoints to be assessed in this trial are consistent with those used in previous","confidence":1,"confidence_rate":1},{"cnt":[[245,561],[647,561],[647,612],[245,612]],"region":{"top_left_x":244,"top_left_y":560,"width":403,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2814881f50d447d9b14975bd6a5065c","type":"text","conversion_output":true,"text":"studies with sprifermin.","text_display":" studies with sprifermin.","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1880,649],[1880,703],[245,703]],"region":{"top_left_x":244,"top_left_y":648,"width":1636,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ee0c9c3789a4b02981c2a595a6eb5a7","type":"text","conversion_output":true,"text":"One of the trial's safety endpoints is the incidence of acute inflammatory reactions (AIRs),","text_display":"\n\nOne of the trial's safety endpoints is the incidence of acute inflammatory reactions (AIRs),","confidence":1,"confidence_rate":1},{"cnt":[[245,698],[1880,698],[1880,750],[245,750]],"region":{"top_left_x":244,"top_left_y":698,"width":1636,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9bc07a1755e45d9b2da882337c72bdf","type":"text","conversion_output":true,"text":"defined as increase of pain by 30 mm on a 100 mm VAS and a self-reported synovial fluid","text_display":" defined as increase of pain by 30 mm on a 100 mm VAS and a self-reported synovial fluid","confidence":0.978515625,"confidence_rate":0.9997870959618445},{"cnt":[[245,746],[1880,746],[1880,797],[245,797]],"region":{"top_left_x":244,"top_left_y":745,"width":1636,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f03f4c064e28490a94ba8f0cb7a32016","type":"text","conversion_output":true,"text":"effusion (i.e., joint swelling) within 3 days following i.a. injection. A similar definition based on","text_display":" effusion (i.e., joint swelling) within 3 days following i.a. injection. A similar definition based on","confidence":0.99853515625,"confidence_rate":0.9999865513043565},{"cnt":[[245,795],[1880,795],[1880,846],[245,846]],"region":{"top_left_x":244,"top_left_y":794,"width":1636,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3d8e5127271449e8943690278d51f88","type":"text","conversion_output":true,"text":"a \\(30- mm\\) increase in pain on VAS and observation of local swelling was used successfully in a","text_display":" a \\(30- mm\\) increase in pain on VAS and observation of local swelling was used successfully in a","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[1880,842],[1880,896],[245,896]],"region":{"top_left_x":244,"top_left_y":842,"width":1636,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21edfc1549b5492e88185054d7053140","type":"text","conversion_output":true,"text":"trial in rheumatoid arthritis involving i.a. injections of interleukin-1 receptor antagonist (IL-1ra;","text_display":" trial in rheumatoid arthritis involving i.a. injections of interleukin-1 receptor antagonist (IL-1ra;","confidence":0.9990236759185791,"confidence_rate":0.9999907849387211},{"cnt":[[245,889],[501,889],[501,943],[245,943]],"region":{"top_left_x":244,"top_left_y":889,"width":257,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f5fe203e3cf43c9ba2135bfe4db7637","type":"text","conversion_output":true,"text":"anakinra (23)).","text_display":" anakinra (23)).","confidence":1,"confidence_rate":1},{"cnt":[[245,980],[1674,980],[1674,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":979,"width":1430,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16755d2453fc43d5b7033f58acb81949","type":"text","conversion_output":true,"text":"The extension phase of the trial will allow exploration of the drug's long-term safety.","text_display":"\n\nThe extension phase of the trial will allow exploration of the drug's long-term safety.","confidence":1,"confidence_rate":1},{"cnt":[[236,1066],[647,1066],[647,1124],[236,1124]],"region":{"top_left_x":236,"top_left_y":1065,"width":411,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c19b1494e89240ef8abaaf603558f45e","type":"section_header","conversion_output":false,"children_ids":["3e78b42dd6c141ce8b49f222ae9aa72c"],"text":"","text_display":""},{"cnt":[[245,1070],[642,1070],[642,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1069,"width":399,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e78b42dd6c141ce8b49f222ae9aa72c","type":"text","conversion_output":true,"parent_id":"c19b1494e89240ef8abaaf603558f45e","text":"Biomarker Assessment","text_display":"\n\n\\section*{Biomarker Assessment}","confidence":1,"confidence_rate":1},{"cnt":[[245,1160],[1880,1160],[1880,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1160,"width":1636,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30d031075bfd4044aaf3ad9da669dc6d","type":"text","conversion_output":true,"text":"Assessment of biomarkers of bone and joint tissue turnover is expected to identify candidate","text_display":"\n\nAssessment of biomarkers of bone and joint tissue turnover is expected to identify candidate","confidence":1,"confidence_rate":1},{"cnt":[[245,1207],[1882,1207],[1882,1259],[245,1259]],"region":{"top_left_x":244,"top_left_y":1207,"width":1639,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bc01cbafbd94939b75845d00df33d05","type":"text","conversion_output":true,"text":"markers potentially predictive of response to treatment, prognostic for disease progression, or","text_display":" markers potentially predictive of response to treatment, prognostic for disease progression, or","confidence":1,"confidence_rate":1},{"cnt":[[245,1255],[1298,1255],[1298,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1254,"width":1054,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65fc70d8ba20408a951e229fc4c8a2ca","type":"text","conversion_output":true,"text":"associated with response to the compound (see Section 7.6.1.).","text_display":" associated with response to the compound (see Section 7.6.1.).","confidence":0.99072265625,"confidence_rate":0.9998608955515392},{"cnt":[[241,1341],[750,1341],[750,1399],[241,1399]],"region":{"top_left_x":240,"top_left_y":1340,"width":510,"height":59},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05afa9713844420ab8a272967d0c446f","type":"section_header","conversion_output":false,"children_ids":["b1843738166a4331b242fcfdca877cf3"],"text":"","text_display":""},{"cnt":[[245,1345],[743,1345],[743,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1344,"width":500,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1843738166a4331b242fcfdca877cf3","type":"text","conversion_output":true,"parent_id":"05afa9713844420ab8a272967d0c446f","text":"Pharmacokinetic Assessment","text_display":"\n\n\\section*{Pharmacokinetic Assessment}","confidence":1,"confidence_rate":1},{"cnt":[[245,1433],[1880,1433],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1433,"width":1636,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9523c07b5cc44726a493fade6b2efe3b","type":"text","conversion_output":true,"text":"The levels of sprifermin/FGF-18 in serum will be assessed 2 hours after the last dose of each","text_display":"\n\nThe levels of sprifermin/FGF-18 in serum will be assessed 2 hours after the last dose of each","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1880,1482],[1880,1534],[245,1534]],"region":{"top_left_x":244,"top_left_y":1482,"width":1636,"height":52},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c24a2daeaa145e19b918a8794ea3a28","type":"text","conversion_output":true,"text":"cycle and will give an indication of whether sprifermin reaches the systemic circulation. Based","text_display":" cycle and will give an indication of whether sprifermin reaches the systemic circulation. Based","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1530],[1807,1530],[1807,1583],[245,1583]],"region":{"top_left_x":244,"top_left_y":1529,"width":1563,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee10bc636f8d445c8a1ee6f52e280bd4","type":"text","conversion_output":true,"text":"on previous trials, systemic levels of sprifermin/FGF-18 are expected to be below the LLOQ.","text_display":" on previous trials, systemic levels of sprifermin/FGF-18 are expected to be below the LLOQ.","confidence":1,"confidence_rate":1},{"cnt":[[245,1620],[1880,1620],[1880,1671],[245,1671]],"region":{"top_left_x":244,"top_left_y":1619,"width":1636,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f50a9fa05dfc4e3ab0b4f962a868ea5d","type":"text","conversion_output":true,"text":"Levels of sprifermin/FGF-18 in synovial fluid will be measured in order to give a first estimate","text_display":"\n\nLevels of sprifermin/FGF-18 in synovial fluid will be measured in order to give a first estimate","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1667],[1188,1667],[1188,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1667,"width":945,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"adefa6f1d62e4acc9f3e0a590582d44e","type":"text","conversion_output":true,"text":"of the residence time of sprifermin in the synovial fluid.","text_display":" of the residence time of sprifermin in the synovial fluid.","confidence":0.99853515625,"confidence_rate":0.9999767317360675},{"cnt":[[236,1749],[999,1749],[999,1815],[236,1815]],"region":{"top_left_x":236,"top_left_y":1748,"width":764,"height":68},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6cd8879e8444eb59565e4adf95088b8","type":"section_header","conversion_output":false,"children_ids":["3a5b867eeaf84729a527c513b75716ef"],"text":"","text_display":""},{"cnt":[[245,1757],[990,1757],[990,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1757,"width":747,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a5b867eeaf84729a527c513b75716ef","type":"text","conversion_output":true,"parent_id":"b6cd8879e8444eb59565e4adf95088b8","text":"Evaluation of Health-related Quality of Life","text_display":"\n\n\\section*{Evaluation of Health-related Quality of Life}","confidence":1,"confidence_rate":1},{"cnt":[[245,1848],[1880,1848],[1880,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1847,"width":1636,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1970d038be684d848b16fb19eccf12e8","type":"text","conversion_output":true,"text":"The KOOS (see Section 7.7.1) is a knee-specific questionnaire designed to evaluate both short-","text_display":"\n\nThe KOOS (see Section 7.7.1) is a knee-specific questionnaire designed to evaluate both short","confidence":1,"confidence_rate":1},{"cnt":[[245,1895],[1880,1895],[1880,1946],[245,1946]],"region":{"top_left_x":244,"top_left_y":1894,"width":1636,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91793f3341264232ae79e13273dcc6c0","type":"text","conversion_output":true,"text":"term and long-term consequences of knee injury, including OA; it is intended for use in knee","text_display":"term and long-term consequences of knee injury, including OA; it is intended for use in knee","confidence":1,"confidence_rate":1},{"cnt":[[245,1942],[1880,1942],[1880,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1942,"width":1636,"height":54},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0de5de00ddfa4463ace1235c99d3267f","type":"text","conversion_output":true,"text":"injury potentially leading to post-traumatic OA or in primary OA. The KOOS QOL subscale is","text_display":" injury potentially leading to post-traumatic OA or in primary OA. The KOOS QOL subscale is","confidence":1,"confidence_rate":1},{"cnt":[[245,1989],[1880,1989],[1880,2043],[245,2043]],"region":{"top_left_x":244,"top_left_y":1989,"width":1636,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ad9f4561748425cbe18b5a647ba6bff","type":"text","conversion_output":true,"text":"more specific to QOL in subjects with knee OA than the more general MOS SF-36 (see below),","text_display":" more specific to QOL in subjects with knee OA than the more general MOS SF-36 (see below),","confidence":1,"confidence_rate":1},{"cnt":[[245,2039],[1197,2039],[1197,2090],[245,2090]],"region":{"top_left_x":244,"top_left_y":2038,"width":953,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce9fc8b71ebb4e3a980b9804f49fd054","type":"text","conversion_output":true,"text":"and may better predict future need for knee replacement.","text_display":" and may better predict future need for knee replacement.","confidence":1,"confidence_rate":1},{"cnt":[[245,2127],[1880,2127],[1880,2179],[245,2179]],"region":{"top_left_x":244,"top_left_y":2126,"width":1636,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d80c32229a1348ff97043ec03ae69de0","type":"text","conversion_output":true,"text":"The MOS SF-36 (see Section 7.7.2) is a generic patient-reported health-related QOL instrument","text_display":"\n\nThe MOS SF-36 (see Section 7.7.2) is a generic patient-reported health-related QOL instrument","confidence":1,"confidence_rate":1},{"cnt":[[243,2176],[1880,2176],[1880,2228],[243,2228]],"region":{"top_left_x":242,"top_left_y":2176,"width":1638,"height":52},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1de25b53ba774d3bb65361a879159d2a","type":"text","conversion_output":true,"text":"that is widely used in different diseases and conditions (including OA). MOS SF-36 results from","text_display":" that is widely used in different diseases and conditions (including OA). MOS SF-36 results from","confidence":1,"confidence_rate":1},{"cnt":[[245,2224],[1882,2224],[1882,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2223,"width":1639,"height":53},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8161f5cb99484289b7b0a7a3b68c9561","type":"text","conversion_output":true,"text":"this trial will be used to determine whether the MOS SF-36 is sensitive enough to measure","text_display":" this trial will be used to determine whether the MOS SF-36 is sensitive enough to measure","confidence":1,"confidence_rate":1},{"cnt":[[245,2271],[907,2271],[907,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2270,"width":663,"height":53},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f4fc7f6ae104848ba448be377bcdf5e","type":"text","conversion_output":true,"text":"changes in QOL in the trial population.","text_display":" changes in QOL in the trial population.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3fc60622158945a9a81f77fdf8dab7ff","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2545],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2545,"width":146,"height":42},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3eac8d8b28a04af499ae0fde427ebd95","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3eb9b26f5695454daa98862ac2faf982","type":"page_info","conversion_output":false,"text":"41/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-042","page":42,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"922288ecaffe46a5a19958ae2b7b4765","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"808fd5eb11ee4bf08d40c3e8a27e33cf","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50d9903096024e0999feb2435c3c63bd","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,275],[1274,275],[1274,346],[236,346]],"region":{"top_left_x":236,"top_left_y":275,"width":1039,"height":71},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a41c2e75f8004fdba8e17a49807b3c76","type":"section_header","conversion_output":false,"children_ids":["54f4698ef44040fe8bec8f7424726019"],"text":"","text_display":""},{"cnt":[[243,279],[1270,279],[1270,342],[243,342]],"region":{"top_left_x":242,"top_left_y":279,"width":1028,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54f4698ef44040fe8bec8f7424726019","type":"text","conversion_output":true,"parent_id":"a41c2e75f8004fdba8e17a49807b3c76","text":"5.2.1 Inclusion of Special Populations","text_display":"\n\n\\subsection*{5.2.1 Inclusion of Special Populations}","confidence":0.9970703125,"confidence_rate":0.9999317700618429},{"cnt":[[245,378],[1884,378],[1884,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":1641,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04b6c989e5f949059455b2aa709089c2","type":"text","conversion_output":true,"text":"The trial population will consist of adults aged between 40 and 85 years. The inclusion of elderly","text_display":"\n\nThe trial population will consist of adults aged between 40 and 85 years. The inclusion of elderly","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[245,425],[1734,425],[1734,477],[245,477]],"region":{"top_left_x":244,"top_left_y":425,"width":1490,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"589318b83edf434aadda5bb0e8c3c5f1","type":"text","conversion_output":true,"text":"subjects is considered justified because this is the group most frequently affected by OA.","text_display":" subjects is considered justified because this is the group most frequently affected by OA.","confidence":0.8731086254119873,"confidence_rate":0.9985726480251073},{"cnt":[[236,511],[1210,511],[1210,582],[236,582]],"region":{"top_left_x":236,"top_left_y":511,"width":974,"height":72},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b760ba3e71ac4fe3a4fef52aabdcf947","type":"section_header","conversion_output":false,"children_ids":["06dc95580b78406fa54d240a90e9b558"],"text":"","text_display":""},{"cnt":[[245,516],[1205,516],[1205,576],[245,576]],"region":{"top_left_x":244,"top_left_y":515,"width":962,"height":61},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06dc95580b78406fa54d240a90e9b558","type":"text","conversion_output":true,"parent_id":"b760ba3e71ac4fe3a4fef52aabdcf947","text":"5.3 Selection of Trial Population","text_display":"\n\n\\subsection*{5.3 Selection of Trial Population}","confidence":0.8857421875,"confidence_rate":0.9967261988419117},{"cnt":[[245,610],[1880,610],[1880,664],[245,664]],"region":{"top_left_x":244,"top_left_y":610,"width":1636,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d44f15fdcf214aeba4f8923fc4d41c83","type":"text","conversion_output":true,"text":"The trial will randomize approximately 545 subjects, in about 10 to 15 centers located in Europe,","text_display":"\n\nThe trial will randomize approximately 545 subjects, in about 10 to 15 centers located in Europe,","confidence":0.9975600242614746,"confidence_rate":0.9999779916175905},{"cnt":[[245,662],[1433,662],[1433,711],[245,711]],"region":{"top_left_x":244,"top_left_y":661,"width":1190,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3479ae0549f54206afaaf880a824c579","type":"text","conversion_output":true,"text":"the United States of America, and possibly other geographical regions.","text_display":" the United States of America, and possibly other geographical regions.","confidence":1,"confidence_rate":1},{"cnt":[[236,746],[986,746],[986,812],[236,812]],"region":{"top_left_x":236,"top_left_y":745,"width":751,"height":68},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2336268f603f4180bbc3577d0bb53729","type":"section_header","conversion_output":false,"children_ids":["54a62b4b1d9041959db39410fbe324b9"],"text":"","text_display":""},{"cnt":[[245,752],[982,752],[982,806],[245,806]],"region":{"top_left_x":244,"top_left_y":751,"width":738,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54a62b4b1d9041959db39410fbe324b9","type":"text","conversion_output":true,"parent_id":"2336268f603f4180bbc3577d0bb53729","text":"5.3.1 Inclusion Criteria","text_display":"\n\n\\subsection*{5.3.1 Inclusion Criteria}","confidence":0.99951171875,"confidence_rate":0.999983158745329},{"cnt":[[245,846],[1588,846],[1588,900],[245,900]],"region":{"top_left_x":244,"top_left_y":846,"width":1344,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09f8fc0a3cbf47948e4b1498916d5adf","type":"text","conversion_output":true,"text":"For inclusion in the trial, all of the following inclusion criteria must be fulfilled:","text_display":"\n\nFor inclusion in the trial, all of the following inclusion criteria must be fulfilled:","confidence":1,"confidence_rate":1},{"cnt":[[247,915],[1880,915],[1880,969],[247,969]],"region":{"top_left_x":247,"top_left_y":915,"width":1633,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c372e8fea1874d0e82161ff27f25eecb","type":"text","conversion_output":true,"text":"1. Written informed consent given prior to any trial-related activity: subjects must understand","text_display":"\n1. Written informed consent given prior to any trial-related activity: subjects must understand","confidence":1,"confidence_rate":1},{"cnt":[[305,967],[1880,967],[1880,1016],[305,1016]],"region":{"top_left_x":305,"top_left_y":966,"width":1575,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6538c1d71ae34965ae4d3e4f33822683","type":"text","conversion_output":true,"text":"and sign the appropriate approved Informed Consent Form(s) - one for the trial (mandatory)","text_display":" and sign the appropriate approved Informed Consent Form(s) - one for the trial (mandatory)","confidence":0.99853515625,"confidence_rate":0.9999845694066055},{"cnt":[[305,1014],[1222,1014],[1222,1068],[305,1068]],"region":{"top_left_x":305,"top_left_y":1014,"width":918,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14dce0d097484c67aa6c427d74424090","type":"text","conversion_output":true,"text":"and one for the pharmacogenetic evaluation (optional)","text_display":" and one for the pharmacogenetic evaluation (optional)","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1882,1079],[1882,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1078,"width":1639,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e7d473882884eee86c6183f58351cfc","type":"text","conversion_output":true,"text":"2. Investigator judgment that the subject is able to comply with trial procedures and","text_display":"\n2. Investigator judgment that the subject is able to comply with trial procedures and","confidence":1,"confidence_rate":1},{"cnt":[[305,1130],[520,1130],[520,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":215,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e0dbbc1dfac4664aa903eb22f41aecb","type":"text","conversion_output":true,"text":"assessments","text_display":" assessments","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1882,1195],[1882,1250],[245,1250]],"region":{"top_left_x":244,"top_left_y":1194,"width":1639,"height":57},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"108567a4f5ee4f04b8d023b1b7232d5e","type":"text","conversion_output":true,"text":"3. Primary femorotibial OA according to American College of Rheumatology (ACR) clinical","text_display":"\n3. Primary femorotibial OA according to American College of Rheumatology (ACR) clinical","confidence":1,"confidence_rate":1},{"cnt":[[305,1246],[1033,1246],[1033,1300],[305,1300]],"region":{"top_left_x":305,"top_left_y":1246,"width":729,"height":54},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8571b881240477a8e0347ac995fc302","type":"text","conversion_output":true,"text":"and radiographic criteria (see Appendix A)","text_display":" and radiographic criteria (see Appendix A)","confidence":1,"confidence_rate":1},{"cnt":[[245,1315],[1882,1315],[1882,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1314,"width":1639,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a65980ddfdb41c1b657fb2b54d7dce6","type":"text","conversion_output":true,"text":"4. Radiological grade of 2 or 3 according to Kellgren-Lawrence and a minimum joint space","text_display":"\n4. Radiological grade of 2 or 3 according to Kellgren-Lawrence and a minimum joint space","confidence":1,"confidence_rate":1},{"cnt":[[305,1362],[1882,1362],[1882,1416],[305,1416]],"region":{"top_left_x":305,"top_left_y":1362,"width":1578,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50dc5064ca824096b42b02079c0d54c2","type":"text","conversion_output":true,"text":"width (JSW) of \\(\\geq 2.5 mm\\) in the medial compartment in the target knee, obtained during","text_display":" width (JSW) of \\(\\geq 2.5 mm\\) in the medial compartment in the target knee, obtained during","confidence":1,"confidence_rate":1},{"cnt":[[305,1414],[488,1414],[488,1463],[305,1463]],"region":{"top_left_x":305,"top_left_y":1413,"width":183,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06128be255e84d0f8214404d224196d8","type":"text","conversion_output":true,"text":"screening.","text_display":" screening.","confidence":1,"confidence_rate":1},{"cnt":[[305,1478],[1882,1478],[1882,1532],[305,1532]],"region":{"top_left_x":305,"top_left_y":1478,"width":1578,"height":54},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0618bc2dc991486eaa6ddccd89422bb0","type":"text","conversion_output":true,"text":"Note: X-rays conducted up to 6 months prior to screening are acceptable, provided they were","text_display":"\nNote: X-rays conducted up to 6 months prior to screening are acceptable, provided they were","confidence":1,"confidence_rate":1},{"cnt":[[305,1525],[1882,1525],[1882,1579],[305,1579]],"region":{"top_left_x":305,"top_left_y":1525,"width":1578,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ac0d27fd32d4373bc69f57788f89b6c","type":"text","conversion_output":true,"text":"performed according to the specifications in the MOP and the quality is acceptable to allow","text_display":" performed according to the specifications in the MOP and the quality is acceptable to allow","confidence":1,"confidence_rate":1},{"cnt":[[305,1575],[1214,1575],[1214,1626],[305,1626]],"region":{"top_left_x":305,"top_left_y":1574,"width":909,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f17647e14354a6792a35fb19cb0e968","type":"text","conversion_output":true,"text":"confirmation of the entry criteria when read centrally.","text_display":" confirmation of the entry criteria when read centrally.","confidence":1,"confidence_rate":1},{"cnt":[[245,1641],[954,1641],[954,1695],[245,1695]],"region":{"top_left_x":244,"top_left_y":1641,"width":710,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eea12e9a743844068f9cc3325637e524","type":"text","conversion_output":true,"text":"5. Age from 40 to 85 years; of either sex","text_display":"\n5. Age from 40 to 85 years; of either sex","confidence":1,"confidence_rate":1},{"cnt":[[245,1710],[1437,1710],[1437,1764],[245,1764]],"region":{"top_left_x":244,"top_left_y":1710,"width":1194,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9151dab1bbc1447bbf802af57df1f97a","type":"text","conversion_output":true,"text":"6. A history of pain due to OA in the target knee for at least 6 months","text_display":"\n6. A history of pain due to OA in the target knee for at least 6 months","confidence":0.9931640625,"confidence_rate":0.9999193043201786},{"cnt":[[245,1779],[1882,1779],[1882,1833],[245,1833]],"region":{"top_left_x":244,"top_left_y":1778,"width":1639,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c61279487a448819d3da2b10b73e3fc","type":"text","conversion_output":true,"text":"7. Pain in the target knee and/or the need for regular symptomatic treatment of knee pain with","text_display":"\n7. Pain in the target knee and/or the need for regular symptomatic treatment of knee pain with","confidence":1,"confidence_rate":1},{"cnt":[[305,1830],[1880,1830],[1880,1882],[305,1882]],"region":{"top_left_x":305,"top_left_y":1830,"width":1575,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fa3cd5489684491842d34112603fb74","type":"text","conversion_output":true,"text":"paracetamol (acetaminophen), systemic non-steroidal anti-inflammatory drugs (NSAIDs)","text_display":" paracetamol (acetaminophen), systemic non-steroidal anti-inflammatory drugs (NSAIDs)","confidence":1,"confidence_rate":1},{"cnt":[[305,1878],[1882,1878],[1882,1929],[305,1929]],"region":{"top_left_x":305,"top_left_y":1877,"width":1578,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83704dee2fca4ed8a618c47099bda551","type":"text","conversion_output":true,"text":"including COX-2 selective inhibitors (coxibs), or tramadol on most days in the previous","text_display":" including COX-2 selective inhibitors (coxibs), or tramadol on most days in the previous","confidence":1,"confidence_rate":1},{"cnt":[[305,1925],[1347,1925],[1347,1979],[305,1979]],"region":{"top_left_x":305,"top_left_y":1925,"width":1043,"height":54},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4e74493805147619476d03aa356bac0","type":"text","conversion_output":true,"text":"month (i.e., more than half of the days in the previous month)","text_display":" month (i.e., more than half of the days in the previous month)","confidence":0.998046875,"confidence_rate":0.9999708208013061},{"cnt":[[245,1994],[1882,1994],[1882,2047],[245,2047]],"region":{"top_left_x":244,"top_left_y":1993,"width":1639,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ded770b802f348fa8d37b67ddab5c4fe","type":"text","conversion_output":true,"text":"8. Pain score for the target knee of 4 to 9 points in response to Question 1 of the WOMAC pain","text_display":"\n8. Pain score for the target knee of 4 to 9 points in response to Question 1 of the WOMAC pain","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[305,2041],[1882,2041],[1882,2095],[305,2095]],"region":{"top_left_x":305,"top_left_y":2041,"width":1578,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe829a733fed4026b61bc0321f0438b3","type":"text","conversion_output":true,"text":"index (\"how much pain have you had [in the target knee, over the past 48 hours] when","text_display":" index (\"how much pain have you had [in the target knee, over the past 48 hours] when","confidence":1,"confidence_rate":1},{"cnt":[[305,2090],[1880,2090],[1880,2142],[305,2142]],"region":{"top_left_x":305,"top_left_y":2090,"width":1575,"height":52},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4319a0969854cdd8d5e8d38cf6508aa","type":"text","conversion_output":true,"text":"walking on a flat surface?\") after washout of at least 5 -half-lives of analgesic medication(s):","text_display":" walking on a flat surface?\") after washout of at least 5 -half-lives of analgesic medication(s):","confidence":0.8416147232055664,"confidence_rate":0.9983433646718519},{"cnt":[[305,2140],[1882,2140],[1882,2189],[305,2189]],"region":{"top_left_x":305,"top_left_y":2139,"width":1578,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3592fc68980f4d19801c950ce038cecf","type":"text","conversion_output":true,"text":"acetaminophen, topical or oral NSAIDS, coxibs, opioids, and/or tramadol. The pain score","text_display":" acetaminophen, topical or oral NSAIDS, coxibs, opioids, and/or tramadol. The pain score","confidence":1,"confidence_rate":1},{"cnt":[[305,2187],[1882,2187],[1882,2237],[305,2237]],"region":{"top_left_x":305,"top_left_y":2187,"width":1578,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd773c6095ba4a918f33cd4abf6d6d6d","type":"text","conversion_output":true,"text":"must qualify at screening (Visit 1a for subjects not receiving analgesic medication at the time","text_display":" must qualify at screening (Visit 1a for subjects not receiving analgesic medication at the time","confidence":1,"confidence_rate":1},{"cnt":[[305,2234],[1882,2234],[1882,2284],[305,2284]],"region":{"top_left_x":305,"top_left_y":2234,"width":1578,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"daabdd17240c46479c93e77b53b525f5","type":"text","conversion_output":true,"text":"of screening and Visit 1b for subjects requiring a washout of analgesic medications) and","text_display":" of screening and Visit 1b for subjects requiring a washout of analgesic medications) and","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[305,2282],[614,2282],[614,2333],[305,2333]],"region":{"top_left_x":305,"top_left_y":2281,"width":310,"height":53},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fb160ee042c4542a2ffc9341d01426a","type":"text","conversion_output":true,"text":"baseline (Visit 2).","text_display":" baseline (Visit 2).","confidence":1,"confidence_rate":1},{"cnt":[[245,2348],[1884,2348],[1884,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2348,"width":1641,"height":54},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe7f99a6440b4347a7e4c35d9600a166","type":"text","conversion_output":true,"text":"9. Women of childbearing potential (defined as any female subjects after puberty, unless","text_display":"\n9. Women of childbearing potential (defined as any female subjects after puberty, unless","confidence":1,"confidence_rate":1},{"cnt":[[305,2398],[1886,2398],[1886,2451],[305,2451]],"region":{"top_left_x":305,"top_left_y":2397,"width":1582,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d23dcb8cdca848c0a1aa5d6f3dd146ed","type":"text","conversion_output":true,"text":"postmenopausal for at least two years or surgically sterile) must use methods of","text_display":" postmenopausal for at least two years or surgically sterile) must use methods of","confidence":1,"confidence_rate":1},{"cnt":[[305,2445],[1884,2445],[1884,2499],[305,2499]],"region":{"top_left_x":305,"top_left_y":2444,"width":1580,"height":55},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"541446dd1c1444378dc558972964ed70","type":"text","conversion_output":true,"text":"contraception with a failure rate less than \\(1 \\%\\) per year when used consistently and correctly,","text_display":" contraception with a failure rate less than \\(1 \\%\\) per year when used consistently and correctly,","confidence":0.9921875,"confidence_rate":0.9999223477927023},{"cnt":[[245,2505],[440,2505],[440,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2505,"width":197,"height":41},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e21b81754d834063849a60f8c0704927","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[391,2544],[391,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":148,"height":46},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"faca6b3e43b94abfa96c537ca956fefc","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1506,2529],[1603,2529],[1603,2563],[1506,2563]],"region":{"top_left_x":1506,"top_left_y":2528,"width":97,"height":36},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d7d255725ff43d5986f76000c79a7a8","type":"page_info","conversion_output":false,"text":"42/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-043","page":43,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27a16dcc3e7247959261b6470ee9249c","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a03e2b263dc420880fb0cb7a74309e1","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80349b67dd5d4b8885543cf820df70e0","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[305,279],[1882,279],[1882,331],[305,331]],"region":{"top_left_x":305,"top_left_y":279,"width":1578,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"420f3e5925e6442da373198fb8cc6054","type":"text","conversion_output":true,"text":"such as implants, injectables, combined oral contraceptives, some intrauterine devices","text_display":"\nsuch as implants, injectables, combined oral contraceptives, some intrauterine devices","confidence":1,"confidence_rate":1},{"cnt":[[305,329],[1882,329],[1882,380],[305,380]],"region":{"top_left_x":305,"top_left_y":328,"width":1578,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ec20ececac5452283a3990cd36188c3","type":"text","conversion_output":true,"text":"(IUDs), sexual abstinence, vasectomized partners, or a double barrier method (use of both a","text_display":" (IUDs), sexual abstinence, vasectomized partners, or a double barrier method (use of both a","confidence":1,"confidence_rate":1},{"cnt":[[305,374],[1880,374],[1880,428],[305,428]],"region":{"top_left_x":305,"top_left_y":373,"width":1575,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e262d6fb8394047bd5f0c28236e695b","type":"text","conversion_output":true,"text":"condom and a diaphragm or cervical/vault cap) with spermicide. Contraceptive use must be","text_display":" condom and a diaphragm or cervical/vault cap) with spermicide. Contraceptive use must be","confidence":1,"confidence_rate":1},{"cnt":[[305,423],[1833,423],[1833,475],[305,475]],"region":{"top_left_x":305,"top_left_y":423,"width":1528,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"253f4c6b021c464a849ed599c5477f49","type":"text","conversion_output":true,"text":"continued throughout the throughout the trial (i.e., until the final extended follow-up visit).","text_display":" continued throughout the throughout the trial (i.e., until the final extended follow-up visit).","confidence":0.994140625,"confidence_rate":0.9999412356418027},{"cnt":[[236,507],[995,507],[995,576],[236,576]],"region":{"top_left_x":236,"top_left_y":507,"width":759,"height":69},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec33feeb1ebc4fd48bcb2519a729ac65","type":"section_header","conversion_output":false,"children_ids":["f65002d2ffdf4143b2ecabbfab4ae73e"],"text":"","text_display":""},{"cnt":[[243,516],[988,516],[988,569],[243,569]],"region":{"top_left_x":242,"top_left_y":515,"width":747,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f65002d2ffdf4143b2ecabbfab4ae73e","type":"text","conversion_output":true,"parent_id":"ec33feeb1ebc4fd48bcb2519a729ac65","text":"5.3.2 Exclusion Criteria","text_display":"\n\n\\subsection*{5.3.2 Exclusion Criteria}","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1745,610],[1745,664],[245,664]],"region":{"top_left_x":244,"top_left_y":610,"width":1501,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec385d1e5f1c49e2a3a14613fdb03c59","type":"text","conversion_output":true,"text":"Subjects are not eligible for this trial if they fulfill any of the following exclusion criteria:","text_display":"\n\nSubjects are not eligible for this trial if they fulfill any of the following exclusion criteria:","confidence":1,"confidence_rate":1},{"cnt":[[247,679],[1880,679],[1880,733],[247,733]],"region":{"top_left_x":247,"top_left_y":678,"width":1633,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5942fc1a5c9445baf534b4bde7bf0ef","type":"text","conversion_output":true,"text":"1. Malalignment of \\(>5\\) degrees in the femorotibial axis of the target knee as assessed by the X-","text_display":"\n1. Malalignment of \\(>5\\) degrees in the femorotibial axis of the target knee as assessed by the X","confidence":0.8556013181805611,"confidence_rate":0.9984870605890457},{"cnt":[[305,728],[1414,728],[1414,780],[305,780]],"region":{"top_left_x":305,"top_left_y":728,"width":1109,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"076cd4ad34be4ecd9da14e2f5b503b14","type":"text","conversion_output":true,"text":"ray with a long-axis view that will be performed during screening","text_display":"ray with a long-axis view that will be performed during screening","confidence":1,"confidence_rate":1},{"cnt":[[243,795],[1882,795],[1882,846],[243,846]],"region":{"top_left_x":242,"top_left_y":794,"width":1641,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6e0388b23c44915867656c0fb3d71b6","type":"text","conversion_output":true,"text":"2. Intra-articular administration of corticosteroids or hyaluronic acid into either knee within 6","text_display":"\n2. Intra-articular administration of corticosteroids or hyaluronic acid into either knee within 6","confidence":0.9951171875,"confidence_rate":0.9999515380814779},{"cnt":[[305,844],[1818,844],[1818,896],[305,896]],"region":{"top_left_x":305,"top_left_y":844,"width":1513,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0333307e64e44b5d89e25bae92a53fc1","type":"text","conversion_output":true,"text":"months, or arthroscopy to the target knee within the past year before the start of screening","text_display":" months, or arthroscopy to the target knee within the past year before the start of screening","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1882,911],[1882,965],[245,965]],"region":{"top_left_x":244,"top_left_y":910,"width":1639,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91a434d127314339a4c2be3c1e0139fd","type":"text","conversion_output":true,"text":"3. Planned knee surgery (affecting either the target or the contralateral knee) within the next","text_display":"\n3. Planned knee surgery (affecting either the target or the contralateral knee) within the next","confidence":1,"confidence_rate":1},{"cnt":[[305,962],[479,962],[479,1012],[305,1012]],"region":{"top_left_x":305,"top_left_y":962,"width":175,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8aecc39681c4df1b2b972729973bbf0","type":"text","conversion_output":true,"text":"two years","text_display":" two years","confidence":1,"confidence_rate":1},{"cnt":[[245,1027],[1360,1027],[1360,1081],[245,1081]],"region":{"top_left_x":244,"top_left_y":1026,"width":1116,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3c774c396844bba8caa3eb843977c70","type":"text","conversion_output":true,"text":"4. Clinical signs of inflammation (i.e., redness) in the target knee","text_display":"\n4. Clinical signs of inflammation (i.e., redness) in the target knee","confidence":0.99462890625,"confidence_rate":0.9999262277907198},{"cnt":[[245,1096],[1646,1096],[1646,1149],[245,1149]],"region":{"top_left_x":244,"top_left_y":1095,"width":1402,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc08fdc3b2e7478e8bc45b660bf4dc94","type":"text","conversion_output":true,"text":"5. Concomitant treatment with any parenteral or oral corticosteroids at study entry","text_display":"\n5. Concomitant treatment with any parenteral or oral corticosteroids at study entry","confidence":1,"confidence_rate":1},{"cnt":[[245,1164],[1880,1164],[1880,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1164,"width":1636,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"664f994db3f9480bb5425c71e60c204b","type":"text","conversion_output":true,"text":"6. Concomitant treatment with parenteral, oral, or topical opioids at study entry, with the","text_display":"\n6. Concomitant treatment with parenteral, oral, or topical opioids at study entry, with the","confidence":1,"confidence_rate":1},{"cnt":[[305,1216],[758,1216],[758,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":454,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"135dd5dd124d4b178cdc31685e4fcab3","type":"text","conversion_output":true,"text":"exception of oral tramadol","text_display":" exception of oral tramadol","confidence":0.99951171875,"confidence_rate":0.9999842452693294},{"cnt":[[245,1283],[1880,1283],[1880,1334],[245,1334]],"region":{"top_left_x":244,"top_left_y":1282,"width":1636,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aaf043d5b8a841af930148891caf2ae6","type":"text","conversion_output":true,"text":"7. Concomitant treatment with a parenteral or oral anticoagulant including heparin,","text_display":"\n7. Concomitant treatment with a parenteral or oral anticoagulant including heparin,","confidence":1,"confidence_rate":1},{"cnt":[[305,1332],[1424,1332],[1424,1381],[305,1381]],"region":{"top_left_x":305,"top_left_y":1332,"width":1120,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff383de540ff49a78b601a0db8ddff34","type":"text","conversion_output":true,"text":"coumadin/warfarin or their derivatives, or any other anticoagulant.","text_display":" coumadin/warfarin or their derivatives, or any other anticoagulant.","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1880,1401],[1880,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79fc607d8ac445f2a9f149581935c2f1","type":"text","conversion_output":true,"text":"8. History of sarcoma or other malignancy within the past five years, except adequately treated","text_display":"\n8. History of sarcoma or other malignancy within the past five years, except adequately treated","confidence":1,"confidence_rate":1},{"cnt":[[305,1448],[1880,1448],[1880,1500],[305,1500]],"region":{"top_left_x":305,"top_left_y":1448,"width":1575,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0cc458727e44c7989baeb5caf8f7f81","type":"text","conversion_output":true,"text":"basal cell or squamous cell carcinoma of the skin, or resected cervical atypia or carcinoma in","text_display":" basal cell or squamous cell carcinoma of the skin, or resected cervical atypia or carcinoma in","confidence":1,"confidence_rate":1},{"cnt":[[305,1495],[385,1495],[385,1540],[305,1540]],"region":{"top_left_x":305,"top_left_y":1495,"width":80,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97df9d7457a8417d9af7a02ed5901f66","type":"text","conversion_output":true,"text":"situ.","text_display":" situ.","confidence":1,"confidence_rate":1},{"cnt":[[245,1564],[1880,1564],[1880,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1564,"width":1636,"height":54},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"890c05eb44024d1abb133ab0a82334e8","type":"text","conversion_output":true,"text":"9. Secondary OA such as joint dysplasia, aseptic osteonecrosis, acromegaly, Paget disease,","text_display":"\n9. Secondary OA such as joint dysplasia, aseptic osteonecrosis, acromegaly, Paget disease,","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[305,1611],[1880,1611],[1880,1665],[305,1665]],"region":{"top_left_x":305,"top_left_y":1611,"width":1575,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ebd413ea40c4c228c2e54cfc18ceac0","type":"text","conversion_output":true,"text":"Ehlers-Danlos syndrome, Stickler syndrome, joint infection (septic arthritis),","text_display":" Ehlers-Danlos syndrome, Stickler syndrome, joint infection (septic arthritis),","confidence":1,"confidence_rate":1},{"cnt":[[305,1661],[1880,1661],[1880,1712],[305,1712]],"region":{"top_left_x":305,"top_left_y":1660,"width":1575,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c787e20ad90645f28a5e4e8fa7655e6c","type":"text","conversion_output":true,"text":"hemochromatosis, gout, chondrocalcinosis (pseudogout), or calcium pyrophosphate","text_display":" hemochromatosis, gout, chondrocalcinosis (pseudogout), or calcium pyrophosphate","confidence":1,"confidence_rate":1},{"cnt":[[305,1710],[629,1710],[629,1760],[305,1760]],"region":{"top_left_x":305,"top_left_y":1710,"width":325,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f76bdb9f4e9449269fad545663369bfd","type":"text","conversion_output":true,"text":"deposition disease.","text_display":" deposition disease.","confidence":1,"confidence_rate":1},{"cnt":[[294,1777],[1622,1777],[1622,1828],[294,1828]],"region":{"top_left_x":294,"top_left_y":1776,"width":1329,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7f379c2d1ea4adb8d0e4e57a479f629","type":"text","conversion_output":true,"text":"(Exception: subjects who have undergone meniscal resection may be enrolled.)","text_display":"\n(Exception: subjects who have undergone meniscal resection may be enrolled.)","confidence":1,"confidence_rate":1},{"cnt":[[249,1846],[846,1846],[846,1897],[249,1897]],"region":{"top_left_x":249,"top_left_y":1845,"width":598,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ef6dc70bb4943f5985b95570d6dbb2c","type":"text","conversion_output":true,"text":"10. Plan to relocate from the region","text_display":"\n10. Plan to relocate from the region","confidence":1,"confidence_rate":1},{"cnt":[[249,1914],[1373,1914],[1373,1966],[249,1966]],"region":{"top_left_x":249,"top_left_y":1914,"width":1124,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f03fcbb6d14f4c079702cf5b9809470f","type":"text","conversion_output":true,"text":"11. Previous participation as a subject in another trial of sprifermin","text_display":"\n11. Previous participation as a subject in another trial of sprifermin","confidence":1,"confidence_rate":1},{"cnt":[[249,1983],[1880,1983],[1880,2035],[249,2035]],"region":{"top_left_x":249,"top_left_y":1983,"width":1631,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5a5f2f160d046389b4ad5ab5606ec73","type":"text","conversion_output":true,"text":"12. Any contraindication to MRI according to MRI guidelines, including the inability to undergo","text_display":"\n12. Any contraindication to MRI according to MRI guidelines, including the inability to undergo","confidence":1,"confidence_rate":1},{"cnt":[[305,2032],[1491,2032],[1491,2082],[305,2082]],"region":{"top_left_x":305,"top_left_y":2032,"width":1187,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f9b3f4f59ea465ebe39a71cc99b8aa6","type":"text","conversion_output":true,"text":"a knee MRI exam because of inability to fit in the scanner or knee coil","text_display":" a knee MRI exam because of inability to fit in the scanner or knee coil","confidence":1,"confidence_rate":1},{"cnt":[[249,2101],[1450,2101],[1450,2151],[249,2151]],"region":{"top_left_x":249,"top_left_y":2101,"width":1202,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4991560866554100b33eda68926040d9","type":"text","conversion_output":true,"text":"13. Significant co-morbidity that would interfere with trial participation","text_display":"\n13. Significant co-morbidity that would interfere with trial participation","confidence":1,"confidence_rate":1},{"cnt":[[249,2168],[1880,2168],[1880,2219],[249,2219]],"region":{"top_left_x":249,"top_left_y":2167,"width":1631,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f09607fb34074fb090555e801a14f115","type":"text","conversion_output":true,"text":"14. Any known active infection, including suspicion of intra-articular infection or infection that","text_display":"\n14. Any known active infection, including suspicion of intra-articular infection or infection that","confidence":1,"confidence_rate":1},{"cnt":[[305,2217],[1880,2217],[1880,2267],[305,2267]],"region":{"top_left_x":305,"top_left_y":2217,"width":1575,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e61583522cd84941b9808f0e36d2bc39","type":"text","conversion_output":true,"text":"might compromise the immune system such as human immunodeficiency virus (HIV) or","text_display":" might compromise the immune system such as human immunodeficiency virus (HIV) or","confidence":1,"confidence_rate":1},{"cnt":[[305,2264],[580,2264],[580,2314],[305,2314]],"region":{"top_left_x":305,"top_left_y":2264,"width":276,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f6c4176cef945cfbb992c82c3af6150","type":"text","conversion_output":true,"text":"hepatitis B or C","text_display":" hepatitis B or C","confidence":1,"confidence_rate":1},{"cnt":[[249,2333],[965,2333],[965,2385],[249,2385]],"region":{"top_left_x":249,"top_left_y":2333,"width":716,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf0b89ea53dd44f4907712ec894b275d","type":"text","conversion_output":true,"text":"15. Abnormal laboratory results including:","text_display":"\n15. Abnormal laboratory results including:","confidence":1,"confidence_rate":1},{"cnt":[[294,2406],[1291,2406],[1291,2460],[294,2460]],"region":{"top_left_x":294,"top_left_y":2406,"width":998,"height":54},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8fd7787049b4721b0afa628c433bb21","type":"text","conversion_output":true,"text":"- Hemoglobin < \\(11.5 g / dL\\) (female) or < \\(13.2 g / dL\\) (male)","text_display":"\n- Hemoglobin < \\(11.5 g / dL\\) (female) or < \\(13.2 g / dL\\) (male)","confidence":0.5071608769321777,"confidence_rate":0.991106532740592},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d23f570b271748d289bfbf1c92605619","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9f77a9766b794de2a7074174822d8fb5","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0de672465b34ecaad96d4ec0155e053","type":"page_info","conversion_output":false,"text":"43/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-044","page":44,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db4a6920d2664e5d8e7592667427c39c","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb73e486cfc34b09b2ec0c24667237c1","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9ce1a2428374c03afb0128856726440","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[294,275],[1558,275],[1558,333],[294,333]],"region":{"top_left_x":294,"top_left_y":275,"width":1264,"height":59},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90bb2dce91b84338ae46fd7311b8f6da","type":"text","conversion_output":true,"text":"- White blood cell (WBC) count \\(<3500\\) cells \\(/ mm ^{3}\\) and \\(>20000\\) cells \\(/ mm ^{3}\\)","text_display":"\n- White blood cell (WBC) count \\(<3500\\) cells \\(/ mm ^{3}\\) and \\(>20000\\) cells \\(/ mm ^{3}\\)","confidence":0.9990234375,"confidence_rate":0.9999904212258001},{"cnt":[[294,354],[1880,354],[1880,406],[294,406]],"region":{"top_left_x":294,"top_left_y":354,"width":1586,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f6f771c054c4542984987992d43d1cc","type":"text","conversion_output":true,"text":"- Platelet count or coagulation tests (prothrombin time, partial thromboplastin time,","text_display":"\n- Platelet count or coagulation tests (prothrombin time, partial thromboplastin time,","confidence":1,"confidence_rate":1},{"cnt":[[344,404],[1648,404],[1648,453],[344,453]],"region":{"top_left_x":343,"top_left_y":403,"width":1305,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4f85d8110e0455fa8d7a563c4cc7ca9","type":"text","conversion_output":true,"text":"International Normalized Ratio) outside the central laboratory's normal range","text_display":" International Normalized Ratio) outside the central laboratory's normal range","confidence":1,"confidence_rate":1},{"cnt":[[294,473],[1742,473],[1742,526],[294,526]],"region":{"top_left_x":294,"top_left_y":472,"width":1449,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"919afa5d0605412abee8b806635e1962","type":"text","conversion_output":true,"text":"- Creatinine clearance rate \\(<30 mL /\\) min estimated using the Cockroft-Gault formula","text_display":"\n- Creatinine clearance rate \\(<30 mL /\\) min estimated using the Cockroft-Gault formula","confidence":0.5185089111328125,"confidence_rate":0.9931817042691929},{"cnt":[[294,546],[1882,546],[1882,597],[294,597]],"region":{"top_left_x":294,"top_left_y":545,"width":1589,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae6cf3d5f4f84bdeb9e260a308d05c67","type":"text","conversion_output":true,"text":"- Aspartate aminotransferase (AST), alanine aminotransferase (ALT), or alkaline","text_display":"\n- Aspartate aminotransferase (AST), alanine aminotransferase (ALT), or alkaline","confidence":1,"confidence_rate":1},{"cnt":[[344,593],[1884,593],[1884,645],[344,645]],"region":{"top_left_x":343,"top_left_y":592,"width":1542,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e50ab8a72e44dc69fe9f0b0fe8ab64d","type":"text","conversion_output":true,"text":"phosphatase (ALP) \\(>2.5\\) times ULN, or total bilirubin \\(>1.5 x\\) ULN. In cases of","text_display":" phosphatase (ALP) \\(>2.5\\) times ULN, or total bilirubin \\(>1.5 x\\) ULN. In cases of","confidence":0.7494792659340419,"confidence_rate":0.9967650569347117},{"cnt":[[344,642],[1880,642],[1880,694],[344,694]],"region":{"top_left_x":343,"top_left_y":642,"width":1537,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d38d907adee404d85b4e797a8534149","type":"text","conversion_output":true,"text":"documented Gilbert syndrome, subjects with elevated bilirubin levels will be permitted to","text_display":" documented Gilbert syndrome, subjects with elevated bilirubin levels will be permitted to","confidence":1,"confidence_rate":1},{"cnt":[[344,692],[1624,692],[1624,741],[344,741]],"region":{"top_left_x":343,"top_left_y":691,"width":1282,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b197cf654abc48fd840e061c4e207904","type":"text","conversion_output":true,"text":"enroll in the study if other liver function tests are within the specified limits.","text_display":" enroll in the study if other liver function tests are within the specified limits.","confidence":0.9970703125,"confidence_rate":0.9999662765751441},{"cnt":[[294,761],[1882,761],[1882,814],[294,814]],"region":{"top_left_x":294,"top_left_y":760,"width":1589,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"805190a32b494c548027151d3c31fbb7","type":"text","conversion_output":true,"text":"- Any other abnormal laboratory results that the Investigator believes should preclude the","text_display":"\n- Any other abnormal laboratory results that the Investigator believes should preclude the","confidence":1,"confidence_rate":1},{"cnt":[[344,812],[907,812],[907,862],[344,862]],"region":{"top_left_x":343,"top_left_y":812,"width":564,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f673000ace384b159bb65b1d7bc3b420","type":"text","conversion_output":true,"text":"subject's participation in the trial","text_display":" subject's participation in the trial","confidence":0.99951171875,"confidence_rate":0.9999880878636791},{"cnt":[[249,877],[776,877],[776,930],[249,930]],"region":{"top_left_x":249,"top_left_y":876,"width":527,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5972571836e747d6ac6f0b9cc3b1e3d0","type":"text","conversion_output":true,"text":"16. Pregnancy or breastfeeding","text_display":"\n16. Pregnancy or breastfeeding","confidence":1,"confidence_rate":1},{"cnt":[[249,945],[1880,945],[1880,999],[249,999]],"region":{"top_left_x":249,"top_left_y":945,"width":1631,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c201bb20e2c45b19a9d47d9a851d411","type":"text","conversion_output":true,"text":"17. Participation in another clinical trial within the 30 days (or 5 half-lives of the investigated","text_display":"\n17. Participation in another clinical trial within the 30 days (or 5 half-lives of the investigated","confidence":1,"confidence_rate":1},{"cnt":[[305,993],[1145,993],[1145,1046],[305,1046]],"region":{"top_left_x":305,"top_left_y":992,"width":841,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40eaa9f2306b4b65908ba5320a8aa4b7","type":"text","conversion_output":true,"text":"compound, whichever is longer) before screening","text_display":" compound, whichever is longer) before screening","confidence":1,"confidence_rate":1},{"cnt":[[249,1061],[1575,1061],[1575,1115],[249,1115]],"region":{"top_left_x":249,"top_left_y":1061,"width":1326,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c29a90c348b4398810e2ab9cf9a2a5c","type":"text","conversion_output":true,"text":"18. Known hypersensitivity to the trial treatment (including placebo) or diluent","text_display":"\n18. Known hypersensitivity to the trial treatment (including placebo) or diluent","confidence":1,"confidence_rate":1},{"cnt":[[249,1130],[1010,1130],[1010,1184],[249,1184]],"region":{"top_left_x":249,"top_left_y":1130,"width":761,"height":54},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58653b3161da43839372badfccf4462c","type":"text","conversion_output":true,"text":"19. Legal incapacity or limited legal capacity","text_display":"\n19. Legal incapacity or limited legal capacity","confidence":1,"confidence_rate":1},{"cnt":[[236,1220],[1184,1220],[1184,1283],[236,1283]],"region":{"top_left_x":236,"top_left_y":1220,"width":948,"height":63},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7704ffb21f94c19a4eefb7379d2485c","type":"section_header","conversion_output":false,"children_ids":["798af1db8a994a4a8b8fd8bb590febd4"],"text":"","text_display":""},{"cnt":[[245,1225],[1177,1225],[1177,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1224,"width":934,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"798af1db8a994a4a8b8fd8bb590febd4","type":"text","conversion_output":true,"parent_id":"f7704ffb21f94c19a4eefb7379d2485c","text":"5.4 Criteria for Randomization","text_display":"\n\n\\subsection*{5.4 Criteria for Randomization}","confidence":0.96826171875,"confidence_rate":0.9990518363315226},{"cnt":[[245,1319],[1882,1319],[1882,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1319,"width":1639,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fa536de92c44e389db41283e0622695","type":"text","conversion_output":true,"text":"Subject's pain level will be assessed during the screening, and eligibility will be confirmed at","text_display":"\n\nSubject's pain level will be assessed during the screening, and eligibility will be confirmed at","confidence":1,"confidence_rate":1},{"cnt":[[245,1371],[402,1371],[402,1414],[245,1414]],"region":{"top_left_x":244,"top_left_y":1370,"width":158,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37be2ea91d5443329e7483cc46aaf3d7","type":"text","conversion_output":true,"text":"baseline.","text_display":" baseline.","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1880,1439],[1880,1491],[245,1491]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f9ad736362b4274a80b3553c59d96be","type":"text","conversion_output":true,"text":"- As an essential part of the eligibility determination process, subjects will be asked to complete","text_display":"\n- As an essential part of the eligibility determination process, subjects will be asked to complete","confidence":1,"confidence_rate":1},{"cnt":[[294,1487],[1880,1487],[1880,1538],[294,1538]],"region":{"top_left_x":294,"top_left_y":1486,"width":1586,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58f60e45e0244afda0a83df34d6b1495","type":"text","conversion_output":true,"text":"Question 1 of the WOMAC pain index (\"How much pain have you had [in the target knee,","text_display":" Question 1 of the WOMAC pain index (\"How much pain have you had [in the target knee,","confidence":1,"confidence_rate":1},{"cnt":[[294,1534],[1558,1534],[1558,1588],[294,1588]],"region":{"top_left_x":294,"top_left_y":1533,"width":1264,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c285606b554d47478cb9634850d3a55f","type":"text","conversion_output":true,"text":"over the past 48 hours] when walking on a flat surface?\"; see Appendix C).","text_display":" over the past 48 hours] when walking on a flat surface?\"; see Appendix C).","confidence":1,"confidence_rate":1},{"cnt":[[292,1603],[1880,1603],[1880,1656],[292,1656]],"region":{"top_left_x":292,"top_left_y":1602,"width":1588,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb3761b9bf504f79aa3b1687a8d6f334","type":"text","conversion_output":true,"text":"The WOMAC questions that determine eligibility must be obtained after the patient has","text_display":"\nThe WOMAC questions that determine eligibility must be obtained after the patient has","confidence":1,"confidence_rate":1},{"cnt":[[292,1652],[1880,1652],[1880,1704],[292,1704]],"region":{"top_left_x":292,"top_left_y":1652,"width":1588,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d24d26edd4eb4f05bbe1911b50b049b2","type":"text","conversion_output":true,"text":"provided informed consent and, if taking pain medications, has withheld them, as described","text_display":" provided informed consent and, if taking pain medications, has withheld them, as described","confidence":1,"confidence_rate":1},{"cnt":[[292,1697],[415,1697],[415,1747],[292,1747]],"region":{"top_left_x":292,"top_left_y":1697,"width":123,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c61adbc93d24186ad0c84eab5e3e1e9","type":"text","conversion_output":true,"text":"below.","text_display":" below.","confidence":1,"confidence_rate":1},{"cnt":[[245,1770],[1882,1770],[1882,1824],[245,1824]],"region":{"top_left_x":244,"top_left_y":1770,"width":1639,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2949372fa88e4922ab90c0ea4425897b","type":"text","conversion_output":true,"text":"- Subjects who are taking pain medications and who are potentially eligible for the trial will be","text_display":"\n- Subjects who are taking pain medications and who are potentially eligible for the trial will be","confidence":1,"confidence_rate":1},{"cnt":[[292,1818],[1880,1818],[1880,1871],[292,1871]],"region":{"top_left_x":292,"top_left_y":1817,"width":1588,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"220397e685d84267ac7a9b4625f7c0bb","type":"text","conversion_output":true,"text":"asked to withhold all pain medications including paracetamol (acetaminophen), NSAIDs","text_display":" asked to withhold all pain medications including paracetamol (acetaminophen), NSAIDs","confidence":1,"confidence_rate":1},{"cnt":[[292,1867],[1882,1867],[1882,1919],[292,1919]],"region":{"top_left_x":292,"top_left_y":1866,"width":1591,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"459e4644c88f4955ab625004c3d399fc","type":"text","conversion_output":true,"text":"including coxibs, opioids, and tramadol for at least 5 half-lives of the given medication before","text_display":" including coxibs, opioids, and tramadol for at least 5 half-lives of the given medication before","confidence":1,"confidence_rate":1},{"cnt":[[292,1916],[1459,1916],[1459,1966],[292,1966]],"region":{"top_left_x":292,"top_left_y":1916,"width":1167,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ec35eae4d1b40629371e9e77669da18","type":"text","conversion_output":true,"text":"the screening (Visit 1b) and baseline (Visit 2) WOMAC assessments.","text_display":" the screening (Visit 1b) and baseline (Visit 2) WOMAC assessments.","confidence":1,"confidence_rate":1},{"cnt":[[292,1985],[1880,1985],[1880,2035],[292,2035]],"region":{"top_left_x":292,"top_left_y":1985,"width":1588,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91494095ef2041c38b6335e9215e870c","type":"text","conversion_output":true,"text":"Aspirin (acetylsalicylic acid) used for cardiovascular protection does not need to be withheld,","text_display":"\n\nAspirin (acetylsalicylic acid) used for cardiovascular protection does not need to be withheld,","confidence":1,"confidence_rate":1},{"cnt":[[292,2032],[1510,2032],[1510,2084],[292,2084]],"region":{"top_left_x":292,"top_left_y":2032,"width":1219,"height":52},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b6e74014522401e9baad90979f7bdaf","type":"text","conversion_output":true,"text":"nor do antidepressants used for management of OA pain and depression.","text_display":" nor do antidepressants used for management of OA pain and depression.","confidence":0.9677734375,"confidence_rate":0.9995574321340965},{"cnt":[[294,2101],[1880,2101],[1880,2151],[294,2151]],"region":{"top_left_x":294,"top_left_y":2101,"width":1586,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e6a0621495546ff8d7c6a2423db4175","type":"text","conversion_output":true,"text":"Subjects must have a score of 4 to 9 points for Question 1 of the WOMAC pain index at the","text_display":"\nSubjects must have a score of 4 to 9 points for Question 1 of the WOMAC pain index at the","confidence":0.9990236759185791,"confidence_rate":0.9999905165401506},{"cnt":[[292,2148],[1291,2148],[1291,2202],[292,2202]],"region":{"top_left_x":292,"top_left_y":2148,"width":1000,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86367dfb105446a8a472ea2cea3e9bb0","type":"text","conversion_output":true,"text":"time of screening (after washout of analgesic medications).","text_display":" time of screening (after washout of analgesic medications).","confidence":1,"confidence_rate":1},{"cnt":[[245,2221],[1882,2221],[1882,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2221,"width":1639,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c356c018a9f141358491b2915d0f3960","type":"text","conversion_output":true,"text":"- To be eligible for randomization subjects must again respond with a score of 4 to 9 in","text_display":"\n- To be eligible for randomization subjects must again respond with a score of 4 to 9 in","confidence":1,"confidence_rate":1},{"cnt":[[292,2269],[1884,2269],[1884,2318],[292,2318]],"region":{"top_left_x":292,"top_left_y":2268,"width":1593,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c2eb90feb5749519b61c02cc1cccd07","type":"text","conversion_output":true,"text":"response to Question 1 on the WOMAC at the time of the baseline visit - after washout of","text_display":" response to Question 1 on the WOMAC at the time of the baseline visit - after washout of","confidence":1,"confidence_rate":1},{"cnt":[[292,2316],[1175,2316],[1175,2368],[292,2368]],"region":{"top_left_x":292,"top_left_y":2316,"width":884,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a88c8210f8e433093d432cc0a40c8fd","type":"text","conversion_output":true,"text":"pain medications for a period of at least 5 half-lives.","text_display":" pain medications for a period of at least 5 half-lives.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9250728c28754f7dae03a6668901f3c6","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2545],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":43},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0540c9e603a04b7796dda9434b6a5de5","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c45f5b4daac4f37a74fa17967dfad1c","type":"page_info","conversion_output":false,"text":"44/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-045","page":45,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebedeebdca2045efb2da3be505bfd33f","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8050b1d1f18485da025724a00029b98","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"145cc3860dbb4ecd90c5e49f395928d9","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a730fb0af174fb5992d8cb0ce95ceab","type":"text","conversion_output":true,"text":"Subjects who satisfy all eligibility criteria and who are willing to continue in the trial will be","text_display":"\n\nSubjects who satisfy all eligibility criteria and who are willing to continue in the trial will be","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1880,329],[1880,376],[245,376]],"region":{"top_left_x":244,"top_left_y":328,"width":1636,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37a4ddac3c88482fa3fea700f0b3531d","type":"text","conversion_output":true,"text":"randomized as described in Section 6.3. Randomization and administration of the first IMP","text_display":" randomized as described in Section 6.3. Randomization and administration of the first IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1721,374],[1721,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1477,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71e6a47026d149838f6c4007f23af8f4","type":"text","conversion_output":true,"text":"injection will take place on the same day as the baseline MRI scan (see Section 7.1.3.1).","text_display":" injection will take place on the same day as the baseline MRI scan (see Section 7.1.3.1).","confidence":1,"confidence_rate":1},{"cnt":[[241,464],[320,464],[320,520],[241,520]],"region":{"top_left_x":240,"top_left_y":464,"width":81,"height":56},"line":7,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"2ac27554c82240ad8aa6232ef211054e","type":"section_header","conversion_output":false,"children_ids":["c7a8fc2f0c834f5684812ff91e23a4fe"],"text":"","text_display":""},{"cnt":[[243,466],[316,466],[316,518],[243,518]],"region":{"top_left_x":242,"top_left_y":466,"width":74,"height":52},"line":8,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"c7a8fc2f0c834f5684812ff91e23a4fe","type":"text","conversion_output":true,"parent_id":"2ac27554c82240ad8aa6232ef211054e","text":"5.5","text_display":"\n\n\\section*{5.5}","confidence":1,"confidence_rate":1},{"cnt":[[589,464],[1283,464],[1283,531],[589,531]],"region":{"top_left_x":588,"top_left_y":464,"width":695,"height":67},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff9b0d363d5b4f78a561946f25f0b1c2","type":"section_header","conversion_output":false,"children_ids":["9dde9c7bcac3413a9a40e047f68a4f61"],"text":"","text_display":""},{"cnt":[[595,468],[1280,468],[1280,524],[595,524]],"region":{"top_left_x":595,"top_left_y":468,"width":686,"height":57},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dde9c7bcac3413a9a40e047f68a4f61","type":"text","conversion_output":true,"parent_id":"ff9b0d363d5b4f78a561946f25f0b1c2","text":"Criteria for Subject Withdrawal","text_display":"\n\n\\section*{Criteria for Subject Withdrawal}","confidence":1,"confidence_rate":1},{"cnt":[[241,563],[1171,563],[1171,621],[241,621]],"region":{"top_left_x":240,"top_left_y":562,"width":931,"height":59},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"266c141feabc416e878b8b53ce011bc5","type":"section_header","conversion_output":false,"children_ids":["329e54da8c784f5ab3b137cf49ebd422"],"text":"","text_display":""},{"cnt":[[245,567],[1167,567],[1167,617],[245,617]],"region":{"top_left_x":244,"top_left_y":567,"width":923,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"329e54da8c784f5ab3b137cf49ebd422","type":"text","conversion_output":true,"parent_id":"266c141feabc416e878b8b53ce011bc5","text":"5.5.1 Withdrawal from the Trial","text_display":"\n\n\\subsection*{5.5.1 Withdrawal from the Trial}","confidence":1,"confidence_rate":1},{"cnt":[[245,662],[1601,662],[1601,711],[245,711]],"region":{"top_left_x":244,"top_left_y":661,"width":1357,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"115863e7ef744cf788d4bbee6d2c9e66","type":"text","conversion_output":true,"text":"Subjects are free to discontinue the trial at any time without giving their reasons.","text_display":"\n\nSubjects are free to discontinue the trial at any time without giving their reasons.","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1880,752],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29caac088cb34836a28a10013a3e3d9c","type":"text","conversion_output":true,"text":"The Investigator may withdraw a subject at any time if this is considered to be in the subject's","text_display":"\nThe Investigator may withdraw a subject at any time if this is considered to be in the subject's","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[466,799],[466,844],[245,844]],"region":{"top_left_x":244,"top_left_y":799,"width":223,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba73a1c38f3a4eee825281a8c69c55e3","type":"text","conversion_output":true,"text":"best interest.","text_display":" best interest.","confidence":1,"confidence_rate":1},{"cnt":[[245,887],[1351,887],[1351,939],[245,939]],"region":{"top_left_x":244,"top_left_y":887,"width":1108,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87a281215e574b68a1bbe9e91bca1b6b","type":"text","conversion_output":true,"text":"A subject must be withdrawn in the event of any of the following:","text_display":"\n\nA subject must be withdrawn in the event of any of the following:","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[904,958],[904,1012],[245,1012]],"region":{"top_left_x":244,"top_left_y":958,"width":661,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2edca1a77464ae492b9d36e52412418","type":"text","conversion_output":true,"text":"- Withdrawal of the subject's consent","text_display":"\n- Withdrawal of the subject's consent","confidence":1,"confidence_rate":1},{"cnt":[[245,1031],[935,1031],[935,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1031,"width":691,"height":54},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6278d40c3a404d04819da5122cf8ad62","type":"text","conversion_output":true,"text":"- Subject's participation in another trial","text_display":"\n- Subject's participation in another trial","confidence":0.99951171875,"confidence_rate":0.9999896085540316},{"cnt":[[245,1121],[1880,1121],[1880,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1121,"width":1636,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5ab712b0d104470b084dfd2766ddbb0","type":"text","conversion_output":true,"text":"If a subject fails to attend scheduled trial assessments, the Investigator must determine the","text_display":"\n\nIf a subject fails to attend scheduled trial assessments, the Investigator must determine the","confidence":1,"confidence_rate":1},{"cnt":[[245,1169],[1452,1169],[1452,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1168,"width":1209,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2da2ef770f7d4de4abafca44a59442a0","type":"text","conversion_output":true,"text":"reasons and the circumstances as completely and accurately as possible.","text_display":" reasons and the circumstances as completely and accurately as possible.","confidence":1,"confidence_rate":1},{"cnt":[[245,1259],[1880,1259],[1880,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1258,"width":1636,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f60a7435951c4dba90cb7b34cb66e011","type":"text","conversion_output":true,"text":"In case of premature withdrawal from the trial, the procedures scheduled for Week 104/Visit 22","text_display":"\n\nIn case of premature withdrawal from the trial, the procedures scheduled for Week 104/Visit 22","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1882,1306],[1882,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1306,"width":1639,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9688b1eeea4a45059cf13a6a28a01299","type":"text","conversion_output":true,"text":"should be performed at the time of withdrawal whenever possible, with focus on the most","text_display":" should be performed at the time of withdrawal whenever possible, with focus on the most","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1863,1354],[1863,1405],[245,1405]],"region":{"top_left_x":244,"top_left_y":1353,"width":1619,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"850cef9d4ae04d559ce8da89910a5456","type":"text","conversion_output":true,"text":"relevant assessments. In any case, the appropriate Case Report Form section must be completed.","text_display":" relevant assessments. In any case, the appropriate Case Report Form section must be completed.","confidence":1,"confidence_rate":1},{"cnt":[[245,1444],[1227,1444],[1227,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1443,"width":983,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7444382292104fc38f0526fbb1801e6f","type":"text","conversion_output":true,"text":"Subjects who withdraw from the trial will not be replaced.","text_display":"\n\nSubjects who withdraw from the trial will not be replaced.","confidence":0.99951171875,"confidence_rate":0.9999922476411908},{"cnt":[[241,1532],[1772,1532],[1772,1596],[241,1596]],"region":{"top_left_x":240,"top_left_y":1531,"width":1533,"height":66},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a48ba08531d445a8ffdb44d21e0eebc","type":"section_header","conversion_output":false,"children_ids":["785f7cfd334f4ea6a013c88daa4ab82d"],"text":"","text_display":""},{"cnt":[[245,1538],[1768,1538],[1768,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1538,"width":1525,"height":54},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"785f7cfd334f4ea6a013c88daa4ab82d","type":"text","conversion_output":true,"parent_id":"0a48ba08531d445a8ffdb44d21e0eebc","text":"5.5.2 Withdrawal from the Investigational Medicinal Product","text_display":"\n\n\\subsection*{5.5.2 Withdrawal from the Investigational Medicinal Product}","confidence":1,"confidence_rate":1},{"cnt":[[245,1629],[1631,1629],[1631,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1628,"width":1387,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbea0f6b0da74406a29f0ff080346039","type":"text","conversion_output":true,"text":"Treatment with the IMP must be discontinued in the event of any of the following:","text_display":"\n\nTreatment with the IMP must be discontinued in the event of any of the following:","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[1880,1702],[1880,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1701,"width":1636,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99f06d76f1594b69b74f44870dc16500","type":"text","conversion_output":true,"text":"- Occurrence of an exclusion criterion which is clinically relevant and affects the subject's","text_display":"\n- Occurrence of an exclusion criterion which is clinically relevant and affects the subject's","confidence":1,"confidence_rate":1},{"cnt":[[294,1749],[1708,1749],[1708,1803],[294,1803]],"region":{"top_left_x":294,"top_left_y":1748,"width":1415,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5cdc2fa3c01949bca4df326da12def91","type":"text","conversion_output":true,"text":"safety, if discontinuation is considered necessary by the Investigator and/or Sponsor","text_display":" safety, if discontinuation is considered necessary by the Investigator and/or Sponsor","confidence":1,"confidence_rate":1},{"cnt":[[245,1822],[1882,1822],[1882,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1821,"width":1639,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb8dafe92d6a4bda90f8d070c83eb082","type":"text","conversion_output":true,"text":"- Occurrence of AEs, if discontinuation of trial drug is desired or considered necessary by the","text_display":"\n- Occurrence of AEs, if discontinuation of trial drug is desired or considered necessary by the","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[294,1869],[812,1869],[812,1923],[294,1923]],"region":{"top_left_x":294,"top_left_y":1869,"width":519,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e311f69cbff44d9f95ee8c205bfd80d5","type":"text","conversion_output":true,"text":"Investigator and/or the subject","text_display":" Investigator and/or the subject","confidence":1,"confidence_rate":1},{"cnt":[[245,1942],[1884,1942],[1884,1992],[245,1992]],"region":{"top_left_x":244,"top_left_y":1942,"width":1641,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07c380bdcfb04d019cf14d1ca812a2f7","type":"text","conversion_output":true,"text":"- Occurrence of pregnancy (see Section 7.4.2 for reporting of pregnancies and follow-up of","text_display":"\n- Occurrence of pregnancy (see Section 7.4.2 for reporting of pregnancies and follow-up of","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[294,1989],[1087,1989],[1087,2041],[294,2041]],"region":{"top_left_x":294,"top_left_y":1989,"width":794,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bbbb5eae8014e758eefac4a4b0d1e31","type":"text","conversion_output":true,"text":"subjects who become pregnant during the trial)","text_display":" subjects who become pregnant during the trial)","confidence":1,"confidence_rate":1},{"cnt":[[245,2062],[1880,2062],[1880,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2062,"width":1636,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c33cf6fd52c24873987064d98fcae10a","type":"text","conversion_output":true,"text":"- Use of a non-permitted concomitant medication, as defined in Section 6.5.2, where the","text_display":"\n- Use of a non-permitted concomitant medication, as defined in Section 6.5.2, where the","confidence":1,"confidence_rate":1},{"cnt":[[294,2110],[1179,2110],[1179,2159],[294,2159]],"region":{"top_left_x":294,"top_left_y":2109,"width":886,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e181506383c84af38793ee649f2b5539","type":"text","conversion_output":true,"text":"predefined consequence is withdrawal from the IMP","text_display":" predefined consequence is withdrawal from the IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1121,2183],[1121,2232],[245,2232]],"region":{"top_left_x":244,"top_left_y":2182,"width":878,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a496876c096d4707bafee176b41bfb9e","type":"text","conversion_output":true,"text":"- Substantial non-compliance or protocol violation","text_display":"\n- Substantial non-compliance or protocol violation","confidence":1,"confidence_rate":1},{"cnt":[[245,2271],[1880,2271],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2270,"width":1636,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d455a390eb9e433e8a321bbc28bd414e","type":"text","conversion_output":true,"text":"Subjects who discontinue IMP treatment prematurely will be followed up as described in Section","text_display":"\n\nSubjects who discontinue IMP treatment prematurely will be followed up as described in Section","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[346,2320],[346,2363],[245,2363]],"region":{"top_left_x":244,"top_left_y":2320,"width":102,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ac98c775778475e8950719f77d55d07","type":"text","conversion_output":true,"text":"7.1.5.","text_display":" 7.1.5.","confidence":0.93798828125,"confidence_rate":0.9941971001168222},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18c61744496f46c29fa2cc472398ea26","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f32a83f8a82346c19b152b239d36d115","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f59e3e89a5b7478eac4210f2fa715a01","type":"page_info","conversion_output":false,"text":"45/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1897,2501],[1897,2597],[1796,2597]],"region":{"top_left_x":1796,"top_left_y":2500,"width":102,"height":98},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4c9c14ee96f49ec9461330885e23a65","type":"page_info","conversion_output":false,"text":"\\(9 \\sqrt{1}\\)","text_display":"","confidence":0.7664785385131836,"confidence_rate":0.9627200126773621}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-046","page":46,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc4e6c1989c24291be9653504f7b91c2","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecae86b72c0b40038648142096a5478e","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa6a7d8a42d14a2b845d0ade61d20cf2","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,275],[1424,275],[1424,339],[236,339]],"region":{"top_left_x":236,"top_left_y":275,"width":1189,"height":65},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ed65525dd684194aafecce72572c952","type":"section_header","conversion_output":false,"children_ids":["51dee3603d19492ca08925f596daddca"],"text":"","text_display":""},{"cnt":[[243,279],[1420,279],[1420,335],[243,335]],"region":{"top_left_x":242,"top_left_y":279,"width":1179,"height":57},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51dee3603d19492ca08925f596daddca","type":"text","conversion_output":true,"parent_id":"4ed65525dd684194aafecce72572c952","text":"5.6 Premature Discontinuation of the Trial","text_display":"\n\n\\subsection*{5.6 Premature Discontinuation of the Trial}","confidence":0.9634639643019227,"confidence_rate":0.9992083944924192},{"cnt":[[243,374],[1687,374],[1687,432],[243,432]],"region":{"top_left_x":242,"top_left_y":373,"width":1445,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f7798942a18465d8b6e31175c469ee7","type":"text","conversion_output":true,"text":"The whole trial may be discontinued prematurely in the event of any of the following:","text_display":"\n\nThe whole trial may be discontinued prematurely in the event of any of the following:","confidence":1,"confidence_rate":1},{"cnt":[[245,449],[947,449],[947,501],[245,501]],"region":{"top_left_x":244,"top_left_y":449,"width":704,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4bc43644e824da6b198b7dc055ce79e","type":"text","conversion_output":true,"text":"- Recommendation by the trial's IDMC.","text_display":"\n- Recommendation by the trial's IDMC.","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1755,520],[1755,574],[245,574]],"region":{"top_left_x":244,"top_left_y":519,"width":1512,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b8309901d9f481fbde075363fb447ab","type":"text","conversion_output":true,"text":"- New information leading to unfavorable risk-benefit judgment of the IMP, e.g., due to:","text_display":"\n- New information leading to unfavorable risk-benefit judgment of the IMP, e.g., due to:","confidence":1,"confidence_rate":1},{"cnt":[[294,593],[1027,593],[1027,647],[294,647]],"region":{"top_left_x":294,"top_left_y":592,"width":733,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db3e63cf04e44bf2b21ef355e9afca1a","type":"text","conversion_output":true,"text":"- Evidence of lack of efficacy of the IMP,","text_display":"\n- Evidence of lack of efficacy of the IMP,","confidence":1,"confidence_rate":1},{"cnt":[[294,662],[1882,662],[1882,715],[294,715]],"region":{"top_left_x":294,"top_left_y":661,"width":1589,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fed01979988d4a46b17ef545413c06e8","type":"text","conversion_output":true,"text":"- Occurrence of significant previously unknown adverse reactions or unexpectedly high","text_display":"\n- Occurrence of significant previously unknown adverse reactions or unexpectedly high","confidence":1,"confidence_rate":1},{"cnt":[[344,713],[1240,713],[1240,765],[344,765]],"region":{"top_left_x":343,"top_left_y":713,"width":897,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"863ee86339164e0c821782541ad2d66f","type":"text","conversion_output":true,"text":"intensity or incidence of known adverse reactions, or","text_display":" intensity or incidence of known adverse reactions, or","confidence":1,"confidence_rate":1},{"cnt":[[294,782],[926,782],[926,836],[294,836]],"region":{"top_left_x":294,"top_left_y":782,"width":632,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83ad1610674648e2ba54fa16d23c2e21","type":"text","conversion_output":true,"text":"- Other unfavorable safety findings.","text_display":"\n- Other unfavorable safety findings.","confidence":1,"confidence_rate":1},{"cnt":[[245,855],[1867,855],[1867,909],[245,909]],"region":{"top_left_x":244,"top_left_y":855,"width":1623,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dac7e647fe034ae4a785d9ad1458e106","type":"text","conversion_output":true,"text":"- Sponsor's decision that continuation of the trial is unjustifiable for medical or ethical reasons.","text_display":"\n- Sponsor's decision that continuation of the trial is unjustifiable for medical or ethical reasons.","confidence":0.9970703125,"confidence_rate":0.9999720576529205},{"cnt":[[245,928],[1880,928],[1880,982],[245,982]],"region":{"top_left_x":244,"top_left_y":928,"width":1636,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9a48bf36d504a4c82db2e3fb8133ea1","type":"text","conversion_output":true,"text":"- Poor enrollment of subjects making completion of the trial within an acceptable time frame","text_display":"\n- Poor enrollment of subjects making completion of the trial within an acceptable time frame","confidence":1,"confidence_rate":1},{"cnt":[[292,975],[449,975],[449,1029],[292,1029]],"region":{"top_left_x":292,"top_left_y":975,"width":158,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b90f96a35b8f49a49346b0bf1e910fc5","type":"text","conversion_output":true,"text":"unlikely.","text_display":" unlikely.","confidence":1,"confidence_rate":1},{"cnt":[[245,1048],[1218,1048],[1218,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1048,"width":975,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4f22bcbc03245b48c4d10c036c68902","type":"text","conversion_output":true,"text":"- Discontinuation of development of the Sponsor's IMP.","text_display":"\n- Discontinuation of development of the Sponsor's IMP.","confidence":0.9990234375,"confidence_rate":0.9999834401430849},{"cnt":[[243,1137],[1880,1137],[1880,1188],[243,1188]],"region":{"top_left_x":242,"top_left_y":1136,"width":1638,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd0c22d19d304cfab2b5bf275afb07b5","type":"text","conversion_output":true,"text":"Health Authorities and Independent Ethics Committees (IECs)/Institutional Review Boards","text_display":"\n\nHealth Authorities and Independent Ethics Committees (IECs)/Institutional Review Boards","confidence":1,"confidence_rate":1},{"cnt":[[245,1186],[1882,1186],[1882,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1185,"width":1639,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2521f8f2de243f1860d4e1f4bfccd7b","type":"text","conversion_output":true,"text":"(IRBs) will be informed about the discontinuation of the trial in accordance with applicable","text_display":" (IRBs) will be informed about the discontinuation of the trial in accordance with applicable","confidence":0.99658203125,"confidence_rate":0.9999647034750034},{"cnt":[[245,1233],[449,1233],[449,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1233,"width":206,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9872d0eea2f2419abea9fa30b5e49598","type":"text","conversion_output":true,"text":"regulations.","text_display":" regulations.","confidence":1,"confidence_rate":1},{"cnt":[[243,1323],[1665,1323],[1665,1377],[243,1377]],"region":{"top_left_x":242,"top_left_y":1323,"width":1424,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cce64bcf62a840c385d90231d1cb4a33","type":"text","conversion_output":true,"text":"The whole trial may be terminated or suspended at the request of Health Authorities.","text_display":"\n\nThe whole trial may be terminated or suspended at the request of Health Authorities.","confidence":1,"confidence_rate":1},{"cnt":[[241,1409],[1141,1409],[1141,1472],[241,1472]],"region":{"top_left_x":240,"top_left_y":1409,"width":901,"height":63},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f3bcdf7b8734105b453bf29a08c843c","type":"section_header","conversion_output":false,"children_ids":["7e57e7bf25fe47c68d5dd1bc56dce32a"],"text":"","text_display":""},{"cnt":[[245,1416],[1137,1416],[1137,1467],[245,1467]],"region":{"top_left_x":244,"top_left_y":1415,"width":893,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e57e7bf25fe47c68d5dd1bc56dce32a","type":"text","conversion_output":true,"parent_id":"2f3bcdf7b8734105b453bf29a08c843c","text":"5.7 Definition of End of Trial","text_display":"\n\n\\subsection*{5.7 Definition of End of Trial}","confidence":0.751953125,"confidence_rate":0.9918879023598952},{"cnt":[[245,1508],[1880,1508],[1880,1562],[245,1562]],"region":{"top_left_x":244,"top_left_y":1508,"width":1636,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"840596f04d384eb8adbaecb7e353f9df","type":"text","conversion_output":true,"text":"For administrative and safety reporting purposes, the end of the trial will be defined as the date","text_display":"\n\nFor administrative and safety reporting purposes, the end of the trial will be defined as the date","confidence":1,"confidence_rate":1},{"cnt":[[245,1560],[1882,1560],[1882,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1559,"width":1639,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b11fb741ef854281b64b4249b79ee7cf","type":"text","conversion_output":true,"text":"of the final clinical database lock at the end of the extended follow-up phase. This provides for a","text_display":" of the final clinical database lock at the end of the extended follow-up phase. This provides for a","confidence":1,"confidence_rate":1},{"cnt":[[245,1607],[1158,1607],[1158,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1607,"width":915,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60fbdd31e06a42039f9a9a926bbd0adc","type":"text","conversion_output":true,"text":"single and conservative definition across all trial sites.","text_display":" single and conservative definition across all trial sites.","confidence":1,"confidence_rate":1},{"cnt":[[241,1693],[1886,1693],[1886,1811],[241,1811]],"region":{"top_left_x":240,"top_left_y":1692,"width":1647,"height":120},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f001217f595e4df7a86d479f0cd9d837","type":"section_header","conversion_output":false,"children_ids":["fa460aa41e85488093b7be357b5f3525","609e242a2d544b62a56ea5fd39d9b028"],"text":"","text_display":""},{"cnt":[[245,1697],[1880,1697],[1880,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1697,"width":1636,"height":59},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa460aa41e85488093b7be357b5f3525","type":"text","conversion_output":true,"parent_id":"f001217f595e4df7a86d479f0cd9d837","text":"6 Investigational Medicinal Products and Other Drugs Used in","text_display":"\n\n\\section*{6 Investigational Medicinal Products and Other Drugs Used in","confidence":1,"confidence_rate":1},{"cnt":[[593,1757],[788,1757],[788,1803],[593,1803]],"region":{"top_left_x":592,"top_left_y":1757,"width":197,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"609e242a2d544b62a56ea5fd39d9b028","type":"text","conversion_output":true,"parent_id":"f001217f595e4df7a86d479f0cd9d837","text":"the Trial","text_display":" the Trial}","confidence":1,"confidence_rate":1},{"cnt":[[245,1848],[1880,1848],[1880,1901],[245,1901]],"region":{"top_left_x":244,"top_left_y":1847,"width":1636,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac962baee0574693ab90393b4435fa85","type":"text","conversion_output":true,"text":"The term \"Investigational Medicinal Product\" (IMP) refers to both the investigational drug","text_display":"\n\nThe term \"Investigational Medicinal Product\" (IMP) refers to both the investigational drug","confidence":1,"confidence_rate":1},{"cnt":[[245,1897],[1016,1897],[1016,1949],[245,1949]],"region":{"top_left_x":244,"top_left_y":1897,"width":773,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b55c2c410e0f46cf897304b687151eea","type":"text","conversion_output":true,"text":"undergoing trial (sprifermin) and the placebo.","text_display":" undergoing trial (sprifermin) and the placebo.","confidence":1,"confidence_rate":1},{"cnt":[[241,1981],[1644,1981],[1644,2052],[241,2052]],"region":{"top_left_x":240,"top_left_y":1980,"width":1404,"height":72},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f58f501ef774162aa44a528906dfd92","type":"section_header","conversion_output":false,"children_ids":["536f180646dc46daacb4e75734b90ed0"],"text":"","text_display":""},{"cnt":[[245,1989],[1635,1989],[1635,2043],[245,2043]],"region":{"top_left_x":244,"top_left_y":1989,"width":1391,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"536f180646dc46daacb4e75734b90ed0","type":"text","conversion_output":true,"parent_id":"5f58f501ef774162aa44a528906dfd92","text":"6.1 Description of Investigational Medicinal Products","text_display":"\n\n\\subsection*{6.1 Description of Investigational Medicinal Products}","confidence":0.9014151096343994,"confidence_rate":0.9981807899922059},{"cnt":[[245,2082],[1880,2082],[1880,2133],[245,2133]],"region":{"top_left_x":244,"top_left_y":2081,"width":1636,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9026da79d9e3412b807bd329a436f2f6","type":"text","conversion_output":true,"text":"Clinical trial materials are manufactured in accordance with Good Manufacturing Practice","text_display":"\n\nClinical trial materials are manufactured in accordance with Good Manufacturing Practice","confidence":1,"confidence_rate":1},{"cnt":[[245,2131],[1880,2131],[1880,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2131,"width":1636,"height":54},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"786f021dfade4f7bb4eb876d4e1d9fb1","type":"text","conversion_output":true,"text":"(GMP). All clinical trial materials will be supplied with Certificates of Analysis and/or Release","text_display":" (GMP). All clinical trial materials will be supplied with Certificates of Analysis and/or Release","confidence":0.9990234375,"confidence_rate":0.9999904212258001},{"cnt":[[245,2179],[1695,2179],[1695,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2178,"width":1452,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f70453d1528b4adcba50a2c29aecca97","type":"text","conversion_output":true,"text":"Statements. Trial drugs will be identified by trial code, kit number, and Sponsor name.","text_display":" Statements. Trial drugs will be identified by trial code, kit number, and Sponsor name.","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[1880,2269],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2268,"width":1636,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa4b4ad7c4db4cf0b6a4c87597a7dfaf","type":"text","conversion_output":true,"text":"IMP packaging and labeling are described in Section 6.6; IMP preparation, handling, and storage","text_display":"\n\nIMP packaging and labeling are described in Section 6.6; IMP preparation, handling, and storage","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1003,2316],[1003,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2316,"width":760,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff1e5547d7114c92834791fd2fb2af5c","type":"text","conversion_output":true,"text":"are described in Section 6.7 and in the MOP.","text_display":" are described in Section 6.7 and in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"418a810f5f8c4edca9c4951d8e4b3d1d","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"00925af61ced4814a1620ca2f95191f8","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"854de0fd6922416f80e1d4d5474a889b","type":"page_info","conversion_output":false,"text":"46/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-047","page":47,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0adf0439af3144128ec0b44324d2be69","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d1a32881186434c88cdb6430d097beb","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ecae125031544efb0bdeeb0b0f9e743","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,277],[840,277],[840,346],[241,346]],"region":{"top_left_x":240,"top_left_y":277,"width":601,"height":69},"line":4,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"31a78641eafb49fbab065a7facaa0a88","type":"section_header","conversion_output":false,"children_ids":["62c0d40f943741b380d982666f8bd6c7"],"text":"","text_display":""},{"cnt":[[245,284],[836,284],[836,342],[245,342]],"region":{"top_left_x":244,"top_left_y":283,"width":592,"height":59},"line":5,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"62c0d40f943741b380d982666f8bd6c7","type":"text","conversion_output":true,"parent_id":"31a78641eafb49fbab065a7facaa0a88","text":"6.1.1 Sprifermin","text_display":"\n\n\\subsection*{6.1.1 Sprifermin}","confidence":1,"confidence_rate":1},{"cnt":[[245,378],[1742,378],[1742,432],[245,432]],"region":{"top_left_x":244,"top_left_y":378,"width":1499,"height":54},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48e2364b00204828bd2b21e04ecaf809","type":"text","conversion_output":true,"text":"Sprifermin is a truncated, non-glycosylated form of FGF-18, containing 170 amino acids.","text_display":"\n\nSprifermin is a truncated, non-glycosylated form of FGF-18, containing 170 amino acids.","confidence":0.989769458770752,"confidence_rate":0.9998917613013838},{"cnt":[[245,468],[1571,468],[1571,522],[245,522]],"region":{"top_left_x":244,"top_left_y":468,"width":1327,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58bb3df4292b450ab10d0797418628f6","type":"text","conversion_output":true,"text":"Two strengths of sprifermin will be supplied in this trial: 30 mcg and 100 mcg .","text_display":"\nTwo strengths of sprifermin will be supplied in this trial: 30 mcg and 100 mcg .","confidence":0.998046875,"confidence_rate":0.9999794208976915},{"cnt":[[245,556],[1880,556],[1880,608],[245,608]],"region":{"top_left_x":244,"top_left_y":556,"width":1636,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b97d97df4ce4b8abc9b24f83462325d","type":"text","conversion_output":true,"text":"Sprifermin will be supplied as a white, sterile, freeze-dried powder in \\(3- mL\\) glass vials, sealed","text_display":"\nSprifermin will be supplied as a white, sterile, freeze-dried powder in \\(3- mL\\) glass vials, sealed","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,606],[1880,606],[1880,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1636,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4b4e87821f649c19f8ae697d8b41afa","type":"text","conversion_output":true,"text":"with rubber stoppers, flip-off caps and aluminum rings. Each vial will contain either 31.5 mcg or","text_display":" with rubber stoppers, flip-off caps and aluminum rings. Each vial will contain either 31.5 mcg or","confidence":0.9799990653991699,"confidence_rate":0.9998111985636247},{"cnt":[[247,653],[1880,653],[1880,707],[247,707]],"region":{"top_left_x":247,"top_left_y":653,"width":1633,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ff0883294c743089061757b977490b7","type":"text","conversion_output":true,"text":"105 mcg of sprifermin active substance; these quantities will include a \\(5 \\%\\) overage, permitting","text_display":" 105 mcg of sprifermin active substance; these quantities will include a \\(5 \\%\\) overage, permitting","confidence":0.9921989440917969,"confidence_rate":0.9999239675185303},{"cnt":[[245,700],[1880,700],[1880,752],[245,752]],"region":{"top_left_x":244,"top_left_y":700,"width":1636,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"990ec452f8f641859b737fcbdd1c11d2","type":"text","conversion_output":true,"text":"extraction of respectively 30 mcg or 100 mcg of sprifermin active substance following","text_display":" extraction of respectively 30 mcg or 100 mcg of sprifermin active substance following","confidence":0.9990236759185791,"confidence_rate":0.9999902320377446},{"cnt":[[245,748],[1880,748],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e44c77c1de5e4245bb8e0a9c8a3c0e6f","type":"text","conversion_output":true,"text":"reconstitution with \\(0.9 \\% w / v\\) Sodium Chloride Injection (referred to herein as \"saline solution\").","text_display":" reconstitution with \\(0.9 \\% w / v\\) Sodium Chloride Injection (referred to herein as \"saline solution\").","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[1880,795],[1880,849],[245,849]],"region":{"top_left_x":244,"top_left_y":794,"width":1636,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ce4a21e17694126b5861eb2c7039fc2","type":"text","conversion_output":true,"text":"Excipients of the formulation are sodium phosphate buffer ( pH 7.2 ), sodium hydroxide, O-","text_display":" Excipients of the formulation are sodium phosphate buffer ( pH 7.2 ), sodium hydroxide, O","confidence":0.6988773345947266,"confidence_rate":0.9964236101797356},{"cnt":[[245,844],[1016,844],[1016,896],[245,896]],"region":{"top_left_x":244,"top_left_y":844,"width":773,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b4bcb46deb740acb7f8d5de1046c69b","type":"text","conversion_output":true,"text":"phosphoric acid, sucrose, and poloxamer 188.","text_display":"phosphoric acid, sucrose, and poloxamer 188.","confidence":1,"confidence_rate":1},{"cnt":[[245,932],[1330,932],[1330,986],[245,986]],"region":{"top_left_x":244,"top_left_y":932,"width":1086,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd516c067226488f94a6106dcf731c7c","type":"text","conversion_output":true,"text":"For all treatment groups, the volume to be administered is 2 mL .","text_display":"\n\nFor all treatment groups, the volume to be administered is 2 mL .","confidence":0.998046875,"confidence_rate":0.9999739332086006},{"cnt":[[241,1023],[771,1023],[771,1081],[241,1081]],"region":{"top_left_x":240,"top_left_y":1022,"width":532,"height":59},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca62ac4b4f6c42fda40435e2358b72b2","type":"section_header","conversion_output":false,"children_ids":["38b990f955124cc9abd868dff3578cfa"],"text":"","text_display":""},{"cnt":[[245,1027],[765,1027],[765,1076],[245,1076]],"region":{"top_left_x":244,"top_left_y":1026,"width":521,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38b990f955124cc9abd868dff3578cfa","type":"text","conversion_output":true,"parent_id":"ca62ac4b4f6c42fda40435e2358b72b2","text":"6.1.2 Placebo","text_display":"\n\n\\subsection*{6.1.2 Placebo}","confidence":1,"confidence_rate":1},{"cnt":[[245,1121],[1880,1121],[1880,1173],[245,1173]],"region":{"top_left_x":244,"top_left_y":1121,"width":1636,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cea68f88758470ab43fa8549a9656ff","type":"text","conversion_output":true,"text":"Placebo will be supplied as a white, sterile, freeze-dried powder visually identical to the active","text_display":"\n\nPlacebo will be supplied as a white, sterile, freeze-dried powder visually identical to the active","confidence":1,"confidence_rate":1},{"cnt":[[245,1169],[1880,1169],[1880,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1168,"width":1636,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a37668050f74d00b43cefca49f659a6","type":"text","conversion_output":true,"text":"product, and will be supplied in packaging identical to that for sprifermin. The excipients will be","text_display":" product, and will be supplied in packaging identical to that for sprifermin. The excipients will be","confidence":0.9990234375,"confidence_rate":0.9999906054321309},{"cnt":[[245,1216],[900,1216],[900,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1216,"width":657,"height":54},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5577956272124fc1a6e7f49c6eded24c","type":"text","conversion_output":true,"text":"identical to those in the active product.","text_display":" identical to those in the active product.","confidence":1,"confidence_rate":1},{"cnt":[[241,1306],[1179,1306],[1179,1371],[241,1371]],"region":{"top_left_x":240,"top_left_y":1306,"width":940,"height":65},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d07855ecf2b4463a82b87f8769eb3ec4","type":"section_header","conversion_output":false,"children_ids":["0895adad4df84232a7aa18b5d4e29b12"],"text":"","text_display":""},{"cnt":[[245,1311],[1175,1311],[1175,1366],[245,1366]],"region":{"top_left_x":244,"top_left_y":1310,"width":932,"height":57},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0895adad4df84232a7aa18b5d4e29b12","type":"text","conversion_output":true,"parent_id":"d07855ecf2b4463a82b87f8769eb3ec4","text":"6.2 Dosage and Administration","text_display":"\n\n\\subsection*{6.2 Dosage and Administration}","confidence":0.984375,"confidence_rate":0.9995228909143262},{"cnt":[[245,1405],[1880,1405],[1880,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a31946207024a59bb262eee04bcb2f5","type":"text","conversion_output":true,"text":"In the DBPC treatment phase, all subjects will receive 4 cycles of treatment with the IMP","text_display":"\n\nIn the DBPC treatment phase, all subjects will receive 4 cycles of treatment with the IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,1452],[1880,1452],[1880,1504],[245,1504]],"region":{"top_left_x":244,"top_left_y":1452,"width":1636,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7375ff272a7d422d840048f5aafe7d01","type":"text","conversion_output":true,"text":"(sprifermin or matching placebo) at intervals of 6 months. Each cycle will consist of 3 once-","text_display":" (sprifermin or matching placebo) at intervals of 6 months. Each cycle will consist of 3 once","confidence":0.994140625,"confidence_rate":0.9999434957455698},{"cnt":[[245,1500],[1244,1500],[1244,1553],[245,1553]],"region":{"top_left_x":244,"top_left_y":1499,"width":1000,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d827667d60444b3b348b75c8e184be5","type":"text","conversion_output":true,"text":"weekly i.a. injections over a period of 3 consecutive weeks.","text_display":"weekly i.a. injections over a period of 3 consecutive weeks.","confidence":0.9878327680053189,"confidence_rate":0.9998199888699274},{"cnt":[[245,1590],[1442,1590],[1442,1641],[245,1641]],"region":{"top_left_x":244,"top_left_y":1589,"width":1198,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ff1c00209d54d62ae1b407850ab571d","type":"text","conversion_output":true,"text":"IMP administration for each treatment group is summarized in Table 1.","text_display":"\n\nIMP administration for each treatment group is summarized in Table 1.","confidence":1,"confidence_rate":1},{"cnt":[[245,1680],[1149,1680],[1149,1732],[245,1732]],"region":{"top_left_x":244,"top_left_y":1680,"width":906,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3058f9d0b7c4722ac0fc537e8f86ff8","type":"figure_label","conversion_output":false,"text":"Table 1 Drug Administration Diagram","text_display":"","confidence":0.9980475902557373,"confidence_rate":0.9999545517727879},{"cnt":[[226,1762],[1867,1762],[1867,2237],[226,2237]],"region":{"top_left_x":225,"top_left_y":1761,"width":1642,"height":476},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ac31484791e4ed3a4b450d22b795bff","type":"table","conversion_output":true,"children_ids":["6d4fd07e138647448e33d91e03a70641","06074dd097354cc2819dac8740415d82","19512fab721246419930bdf267eed1af","54ca22cb2ab74df793dac0cd7d7b406b","4dbcab79f301463299ed8daee0d1fa22","2a26d3ed4b9343d5a6a4180500b2e8c2","328b8cc112e44649bb2c40fe29193a5c","4c985cb6f97a478b8811ae70ec27300b","1f3cb4f9074f408ca7c4201e76bd993c","b99b373e38984626bf899d02b3cc3c1a","46206d3cca8f453385b86dbaea91211c","9430d0ebfa564432b45277c6bdd8f5ae","8b19285e62b147d6aa23d5db1830e026","eddb3dc0d7ce420eb78fa86fd96b7c2b","2aacc2cac622422bbc373bcb849a9bae","65135cd585ad4054b8465a8ed4d6d6da","ecee09ce9b9e43548b8bbd9a39eecae4","824493cd5c7b430ca77cb638f75ee78b","d2cdb1c161524c52bb8ed24e2cea425b","2609306f98934349bbc4ec853e930202","83102b2859734795af392fbe5cf5864a","80bfd1bcb5774c4b91b562f26434feaa","5971d49f012b45759409b340e1cf034c","fa4b814341a14e0b8bfe1b4e23b5f1ed","750c49165b864acaa75b39e0c53ae58b","a5d778ad15654e628ef06c7562084869","5a6a9e1e8e984c58afc7e62b10b029eb","07a84f82eb6d495784675a62db453124","14334bcedc2c4a1d988168b4108f1ac3","911d0e2ec2f14c2eb926c7e1e2b4bc4e","f47b322a08d2462e87ce35d76cc5ca4f","f4820b18f5d1404ab65535c9710ce8a5","5b30958c57bb494f873cf87d734fb377","b92c21d8ed8c4c2eba24575dd4e3fe9b","0643359e8af84775bf4818495219ac60","88a50d7e87b048e78b3fdd2d753d46ec","1cfa56246e7d40ee80caee63d53f2980","e16de7c528d8447d8964e37cba28722e","fd3fe70b6e9c438e9205b8a2a30fdde3","f9f606613a31477ca90091785f9a7f18","b26dbb4963aa4cec941fb515e0fc6eaa","a87a03383ab94471b9ef381afb81e5eb","bc1797ee56ac4b6dad6b046afcfe6412","39166028abd8492dafb6890a418e9529","c642d535f15947599754c464e6c49354","1f7a910232d34cbd9dafa4090f5da7e0","a6369bf6a3cf4ab18faba590716e3a2f","cc7deb9e7c88496c9a8f3efb1917a23f","a5fa78a8547646848b211cf749d70aa3","0b15378ef31c4ab4a2ea23f4ad81f461","c7c977c54b434ae98fd45510b82b9ac2","18fc97a6039a4082988da2f16d7cf62a","df2cd3326f33417184970251f5a0b6a2","8fb2103a74f445b7af316dd2f0a6bd92","37168e3158654548944d5ef18f4a539f","587afa0b7b8c4ec9910c04a3772f357c"],"selected_labels":["e3058f9d0b7c4722ac0fc537e8f86ff8"],"text":"\\begin{tabular}{|l|l|l|l|l|l|l|}\n\\hline & Cycle 1 W0, W1, W2 & Cycle 2 W26, W27, W28 & Cycle 3 W52, W53, W54 & Cycle 4 W78, W79, W80 & Dose per cycle & Total dose \\\\\n\\hline Group 1 & 100 mcg & 100 mcg & 100 mcg & 100 mcg & 300 mcg & 1200 mcg \\\\\n\\hline Group 2 & 100 mcg & Placebo & 100 mcg & Placebo & \\(300 mcg /\\) placebo & 600 mcg \\\\\n\\hline Group 3 & 30 mcg & 30 mcg & 30 mcg & 30 mcg & 90 mcg & 360 mcg \\\\\n\\hline Group 4 & 30 mcg & Placebo & 30 mcg & Placebo & \\(90 mcg /\\) placebo & 180 mcg \\\\\n\\hline Group 5 & Placebo & Placebo & Placebo & Placebo & Placebo & Placebo \\\\\n\\hline \\multicolumn{7}{|l|}{Each cycle consists of 3 once-weekly i.a. injections of the specified dose over 3 consecutive weeks.} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 1 Drug Administration Diagram}\n\\begin{tabular}{|l|l|l|l|l|l|l|}\n\\hline & Cycle 1 W0, W1, W2 & Cycle 2 W26, W27, W28 & Cycle 3 W52, W53, W54 & Cycle 4 W78, W79, W80 & Dose per cycle & Total dose \\\\\n\\hline Group 1 & 100 mcg & 100 mcg & 100 mcg & 100 mcg & 300 mcg & 1200 mcg \\\\\n\\hline Group 2 & 100 mcg & Placebo & 100 mcg & Placebo & \\(300 mcg /\\) placebo & 600 mcg \\\\\n\\hline Group 3 & 30 mcg & 30 mcg & 30 mcg & 30 mcg & 90 mcg & 360 mcg \\\\\n\\hline Group 4 & 30 mcg & Placebo & 30 mcg & Placebo & \\(90 mcg /\\) placebo & 180 mcg \\\\\n\\hline Group 5 & Placebo & Placebo & Placebo & Placebo & Placebo & Placebo \\\\\n\\hline \\multicolumn{7}{|l|}{Each cycle consists of 3 once-weekly i.a. injections of the specified dose over 3 consecutive weeks.} \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.8173717558383942,"confidence_rate":0.9997075485444862},{"cnt":[[244,1761],[374,1761],[374,2237],[244,2237]],"region":{"top_left_x":244,"top_left_y":1761,"width":131,"height":477},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d4fd07e138647448e33d91e03a70641","type":"table_column","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[390,1761],[584,1761],[584,2237],[390,2237]],"region":{"top_left_x":389,"top_left_y":1761,"width":196,"height":477},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06074dd097354cc2819dac8740415d82","type":"table_column","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[604,1761],[846,1761],[846,2237],[604,2237]],"region":{"top_left_x":603,"top_left_y":1761,"width":244,"height":477},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19512fab721246419930bdf267eed1af","type":"table_column","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[868,1761],[1115,1761],[1115,2237],[868,2237]],"region":{"top_left_x":868,"top_left_y":1761,"width":248,"height":477},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54ca22cb2ab74df793dac0cd7d7b406b","type":"table_column","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[1130,1761],[1381,1761],[1381,2237],[1130,2237]],"region":{"top_left_x":1130,"top_left_y":1761,"width":252,"height":477},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4dbcab79f301463299ed8daee0d1fa22","type":"table_column","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[1403,1761],[1652,1761],[1652,2237],[1403,2237]],"region":{"top_left_x":1403,"top_left_y":1761,"width":250,"height":477},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a26d3ed4b9343d5a6a4180500b2e8c2","type":"table_column","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[1674,1761],[1847,1761],[1847,2237],[1674,2237]],"region":{"top_left_x":1673,"top_left_y":1761,"width":174,"height":477},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"328b8cc112e44649bb2c40fe29193a5c","type":"table_column","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[225,1778],[1869,1778],[1869,1876],[225,1876]],"region":{"top_left_x":225,"top_left_y":1778,"width":1644,"height":98},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c985cb6f97a478b8811ae70ec27300b","type":"table_row","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[225,1926],[1866,1926],[1866,1971],[225,1971]],"region":{"top_left_x":225,"top_left_y":1925,"width":1642,"height":47},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f3cb4f9074f408ca7c4201e76bd993c","type":"table_row","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[225,1980],[1866,1980],[1866,2023],[225,2023]],"region":{"top_left_x":225,"top_left_y":1979,"width":1642,"height":45},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b99b373e38984626bf899d02b3cc3c1a","type":"table_row","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[225,2032],[1866,2032],[1866,2075],[225,2075]],"region":{"top_left_x":225,"top_left_y":2031,"width":1642,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46206d3cca8f453385b86dbaea91211c","type":"table_row","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[225,2081],[1866,2081],[1866,2127],[225,2127]],"region":{"top_left_x":225,"top_left_y":2081,"width":1642,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9430d0ebfa564432b45277c6bdd8f5ae","type":"table_row","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[225,2133],[1866,2133],[1866,2179],[225,2179]],"region":{"top_left_x":225,"top_left_y":2133,"width":1642,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b19285e62b147d6aa23d5db1830e026","type":"table_row","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[225,2183],[1866,2183],[1866,2231],[225,2231]],"region":{"top_left_x":225,"top_left_y":2183,"width":1642,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eddb3dc0d7ce420eb78fa86fd96b7c2b","type":"table_row","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"","text_display":""},{"cnt":[[398,1783],[582,1783],[582,1871],[398,1871]],"region":{"top_left_x":398,"top_left_y":1782,"width":185,"height":90},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2aacc2cac622422bbc373bcb849a9bae","type":"complex_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","children_ids":["ab47617d9e4d49d4a7de969c34f6eb3a","a2184e894798441fa3da37e9497ece3d"],"text":"Cycle 1 W0, W1, W2","text_display":"Cycle 1 W0, W1, W2","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9980475902557373,"confidence_rate":0.9999348581824669},{"cnt":[[433,1785],[543,1785],[543,1819],[433,1819]],"region":{"top_left_x":432,"top_left_y":1784,"width":112,"height":36},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab47617d9e4d49d4a7de969c34f6eb3a","type":"text","conversion_output":false,"parent_id":"2aacc2cac622422bbc373bcb849a9bae","text":"Cycle 1","text_display":"Cycle 1","confidence":1,"confidence_rate":1},{"cnt":[[398,1835],[580,1835],[580,1871],[398,1871]],"region":{"top_left_x":398,"top_left_y":1834,"width":183,"height":38},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2184e894798441fa3da37e9497ece3d","type":"text","conversion_output":false,"parent_id":"2aacc2cac622422bbc373bcb849a9bae","text":"W0, W1, W2","text_display":" W0, W1, W2","confidence":0.9980475902557373,"confidence_rate":0.9998697206083901},{"cnt":[[608,1783],[844,1783],[844,1871],[608,1871]],"region":{"top_left_x":608,"top_left_y":1782,"width":237,"height":90},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65135cd585ad4054b8465a8ed4d6d6da","type":"complex_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","children_ids":["139c03f8f235483aa89813af24ae25a3","8849a6a127a647e59998919ed614c4c6"],"text":"Cycle 2 W26, W27, W28","text_display":"Cycle 2 W26, W27, W28","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[669,1783],[786,1783],[786,1822],[669,1822]],"region":{"top_left_x":668,"top_left_y":1782,"width":118,"height":40},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"139c03f8f235483aa89813af24ae25a3","type":"text","conversion_output":false,"parent_id":"65135cd585ad4054b8465a8ed4d6d6da","text":"Cycle 2","text_display":"Cycle 2","confidence":1,"confidence_rate":1},{"cnt":[[610,1835],[842,1835],[842,1871],[610,1871]],"region":{"top_left_x":610,"top_left_y":1834,"width":233,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8849a6a127a647e59998919ed614c4c6","type":"text","conversion_output":false,"parent_id":"65135cd585ad4054b8465a8ed4d6d6da","text":"W26, W27, W28","text_display":" W26, W27, W28","confidence":1,"confidence_rate":1},{"cnt":[[872,1780],[1111,1780],[1111,1871],[872,1871]],"region":{"top_left_x":872,"top_left_y":1780,"width":239,"height":92},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecee09ce9b9e43548b8bbd9a39eecae4","type":"complex_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","children_ids":["79d0f1f828204cb2b231535bf7c13334","3f3ee565581047d39c5085b80a122b71"],"text":"Cycle 3 W52, W53, W54","text_display":"Cycle 3 W52, W53, W54","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[935,1783],[1050,1783],[1050,1822],[935,1822]],"region":{"top_left_x":935,"top_left_y":1782,"width":116,"height":40},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79d0f1f828204cb2b231535bf7c13334","type":"text","conversion_output":false,"parent_id":"ecee09ce9b9e43548b8bbd9a39eecae4","text":"Cycle 3","text_display":"Cycle 3","confidence":1,"confidence_rate":1},{"cnt":[[875,1835],[1111,1835],[1111,1871],[875,1871]],"region":{"top_left_x":874,"top_left_y":1834,"width":237,"height":38},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f3ee565581047d39c5085b80a122b71","type":"text","conversion_output":false,"parent_id":"ecee09ce9b9e43548b8bbd9a39eecae4","text":"W52, W53, W54","text_display":" W52, W53, W54","confidence":1,"confidence_rate":1},{"cnt":[[1139,1780],[1377,1780],[1377,1874],[1139,1874]],"region":{"top_left_x":1138,"top_left_y":1780,"width":240,"height":94},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"824493cd5c7b430ca77cb638f75ee78b","type":"complex_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","children_ids":["27f6fe9e8b8e49a0b489349f1d1b3b6e","5b081e4200db4057b7f24ed450b57034"],"text":"Cycle 4 W78, W79, W80","text_display":"Cycle 4 W78, W79, W80","cell_row":0,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1199,1783],[1319,1783],[1319,1824],[1199,1824]],"region":{"top_left_x":1199,"top_left_y":1782,"width":120,"height":42},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27f6fe9e8b8e49a0b489349f1d1b3b6e","type":"text","conversion_output":false,"parent_id":"824493cd5c7b430ca77cb638f75ee78b","text":"Cycle 4","text_display":"Cycle 4","confidence":1,"confidence_rate":1},{"cnt":[[1139,1835],[1375,1835],[1375,1871],[1139,1871]],"region":{"top_left_x":1138,"top_left_y":1834,"width":237,"height":38},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b081e4200db4057b7f24ed450b57034","type":"text","conversion_output":false,"parent_id":"824493cd5c7b430ca77cb638f75ee78b","text":"W78, W79, W80","text_display":" W78, W79, W80","confidence":1,"confidence_rate":1},{"cnt":[[1414,1783],[1639,1783],[1639,1824],[1414,1824]],"region":{"top_left_x":1413,"top_left_y":1782,"width":227,"height":42},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2cdb1c161524c52bb8ed24e2cea425b","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Dose per cycle","text_display":"Dose per cycle","cell_row":0,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1680,1783],[1843,1783],[1843,1819],[1680,1819]],"region":{"top_left_x":1680,"top_left_y":1782,"width":163,"height":38},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2609306f98934349bbc4ec853e930202","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Total dose","text_display":"Total dose","cell_row":0,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1930],[366,1930],[366,1967],[247,1967]],"region":{"top_left_x":246,"top_left_y":1929,"width":120,"height":38},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83102b2859734795af392fbe5cf5864a","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Group 1","text_display":"Group 1","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[426,1930],[552,1930],[552,1967],[426,1967]],"region":{"top_left_x":426,"top_left_y":1929,"width":126,"height":38},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80bfd1bcb5774c4b91b562f26434feaa","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"100 mcg","text_display":"100 mcg","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[667,1930],[790,1930],[790,1967],[667,1967]],"region":{"top_left_x":666,"top_left_y":1929,"width":125,"height":38},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5971d49f012b45759409b340e1cf034c","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"100 mcg","text_display":"100 mcg","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[931,1930],[1054,1930],[1054,1967],[931,1967]],"region":{"top_left_x":930,"top_left_y":1929,"width":125,"height":38},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa4b814341a14e0b8bfe1b4e23b5f1ed","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"100 mcg","text_display":"100 mcg","cell_row":1,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1195,1930],[1319,1930],[1319,1967],[1195,1967]],"region":{"top_left_x":1195,"top_left_y":1929,"width":124,"height":38},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"750c49165b864acaa75b39e0c53ae58b","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"100 mcg","text_display":"100 mcg","cell_row":1,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9998371335216855},{"cnt":[[1464,1930],[1589,1930],[1589,1967],[1464,1967]],"region":{"top_left_x":1463,"top_left_y":1929,"width":127,"height":38},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5d778ad15654e628ef06c7562084869","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"300 mcg","text_display":"300 mcg","cell_row":1,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1693,1930],[1834,1930],[1834,1967],[1693,1967]],"region":{"top_left_x":1693,"top_left_y":1929,"width":141,"height":38},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a6a9e1e8e984c58afc7e62b10b029eb","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"1200 mcg","text_display":"1200 mcg","cell_row":1,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9998534189757986},{"cnt":[[247,1982],[366,1982],[366,2019],[247,2019]],"region":{"top_left_x":246,"top_left_y":1981,"width":120,"height":38},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07a84f82eb6d495784675a62db453124","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Group 2","text_display":"Group 2","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[429,1982],[552,1982],[552,2019],[429,2019]],"region":{"top_left_x":428,"top_left_y":1981,"width":124,"height":38},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14334bcedc2c4a1d988168b4108f1ac3","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"100 mcg","text_display":"100 mcg","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[667,1982],[786,1982],[786,2014],[667,2014]],"region":{"top_left_x":666,"top_left_y":1981,"width":120,"height":34},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"911d0e2ec2f14c2eb926c7e1e2b4bc4e","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[931,1982],[1054,1982],[1054,2019],[931,2019]],"region":{"top_left_x":930,"top_left_y":1981,"width":125,"height":38},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f47b322a08d2462e87ce35d76cc5ca4f","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"100 mcg","text_display":"100 mcg","cell_row":2,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1197,1982],[1319,1982],[1319,2014],[1197,2014]],"region":{"top_left_x":1197,"top_left_y":1981,"width":122,"height":34},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4820b18f5d1404ab65535c9710ce8a5","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":2,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1405,1982],[1652,1982],[1652,2019],[1405,2019]],"region":{"top_left_x":1405,"top_left_y":1981,"width":248,"height":38},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b30958c57bb494f873cf87d734fb377","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"\\(300 mcg /\\) placebo","text_display":"\\(300 mcg /\\) placebo","cell_row":2,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":0.8173717558383942,"confidence_rate":0.9908754625602457},{"cnt":[[1698,1982],[1825,1982],[1825,2019],[1698,2019]],"region":{"top_left_x":1697,"top_left_y":1981,"width":129,"height":38},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b92c21d8ed8c4c2eba24575dd4e3fe9b","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"600 mcg","text_display":"600 mcg","cell_row":2,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2034],[366,2034],[366,2071],[247,2071]],"region":{"top_left_x":246,"top_left_y":2033,"width":120,"height":38},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0643359e8af84775bf4818495219ac60","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Group 3","text_display":"Group 3","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,2034],[543,2034],[543,2071],[433,2071]],"region":{"top_left_x":432,"top_left_y":2033,"width":112,"height":38},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88a50d7e87b048e78b3fdd2d753d46ec","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"30 mcg","text_display":"30 mcg","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[671,2034],[782,2034],[782,2071],[671,2071]],"region":{"top_left_x":671,"top_left_y":2033,"width":111,"height":38},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cfa56246e7d40ee80caee63d53f2980","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"30 mcg","text_display":"30 mcg","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[940,2034],[1046,2034],[1046,2071],[940,2071]],"region":{"top_left_x":939,"top_left_y":2033,"width":107,"height":38},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e16de7c528d8447d8964e37cba28722e","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"30 mcg","text_display":"30 mcg","cell_row":3,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1204,2034],[1310,2034],[1310,2071],[1204,2071]],"region":{"top_left_x":1203,"top_left_y":2033,"width":107,"height":38},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd3fe70b6e9c438e9205b8a2a30fdde3","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"30 mcg","text_display":"30 mcg","cell_row":3,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1472,2034],[1583,2034],[1583,2071],[1472,2071]],"region":{"top_left_x":1472,"top_left_y":2033,"width":111,"height":38},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9f606613a31477ca90091785f9a7f18","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"90 mcg","text_display":"90 mcg","cell_row":3,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1698,2034],[1825,2034],[1825,2071],[1698,2071]],"region":{"top_left_x":1697,"top_left_y":2033,"width":129,"height":38},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b26dbb4963aa4cec941fb515e0fc6eaa","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"360 mcg","text_display":"360 mcg","cell_row":3,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2086],[366,2086],[366,2123],[247,2123]],"region":{"top_left_x":246,"top_left_y":2085,"width":120,"height":38},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a87a03383ab94471b9ef381afb81e5eb","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Group 4","text_display":"Group 4","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,2086],[543,2086],[543,2123],[433,2123]],"region":{"top_left_x":432,"top_left_y":2085,"width":112,"height":38},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc1797ee56ac4b6dad6b046afcfe6412","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"30 mcg","text_display":"30 mcg","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[667,2086],[786,2086],[786,2118],[667,2118]],"region":{"top_left_x":666,"top_left_y":2085,"width":120,"height":34},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39166028abd8492dafb6890a418e9529","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[937,2086],[1046,2086],[1046,2123],[937,2123]],"region":{"top_left_x":937,"top_left_y":2085,"width":109,"height":38},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c642d535f15947599754c464e6c49354","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"30 mcg","text_display":"30 mcg","cell_row":4,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1197,2086],[1319,2086],[1319,2118],[1197,2118]],"region":{"top_left_x":1197,"top_left_y":2085,"width":122,"height":34},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f7a910232d34cbd9dafa4090f5da7e0","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":4,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1414,2086],[1641,2086],[1641,2123],[1414,2123]],"region":{"top_left_x":1413,"top_left_y":2085,"width":229,"height":38},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6369bf6a3cf4ab18faba590716e3a2f","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"\\(90 mcg /\\) placebo","text_display":"\\(90 mcg /\\) placebo","cell_row":4,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":0.9498266691480239,"confidence_rate":0.9975517749194828},{"cnt":[[1700,2086],[1825,2086],[1825,2123],[1700,2123]],"region":{"top_left_x":1699,"top_left_y":2085,"width":127,"height":38},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc7deb9e7c88496c9a8f3efb1917a23f","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"180 mcg","text_display":"180 mcg","cell_row":4,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2138],[366,2138],[366,2175],[247,2175]],"region":{"top_left_x":246,"top_left_y":2137,"width":120,"height":38},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5fa78a8547646848b211cf749d70aa3","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Group 5","text_display":"Group 5","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[429,2138],[548,2138],[548,2170],[429,2170]],"region":{"top_left_x":428,"top_left_y":2137,"width":120,"height":34},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b15378ef31c4ab4a2ea23f4ad81f461","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[667,2138],[786,2138],[786,2170],[667,2170]],"region":{"top_left_x":666,"top_left_y":2137,"width":120,"height":34},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7c977c54b434ae98fd45510b82b9ac2","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":5,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[931,2138],[1052,2138],[1052,2170],[931,2170]],"region":{"top_left_x":930,"top_left_y":2137,"width":123,"height":34},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18fc97a6039a4082988da2f16d7cf62a","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":5,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1199,2138],[1319,2138],[1319,2170],[1199,2170]],"region":{"top_left_x":1199,"top_left_y":2137,"width":120,"height":34},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df2cd3326f33417184970251f5a0b6a2","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":5,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1468,2138],[1587,2138],[1587,2170],[1468,2170]],"region":{"top_left_x":1467,"top_left_y":2137,"width":121,"height":34},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fb2103a74f445b7af316dd2f0a6bd92","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":5,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1702,2138],[1821,2138],[1821,2170],[1702,2170]],"region":{"top_left_x":1701,"top_left_y":2137,"width":120,"height":34},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37168e3158654548944d5ef18f4a539f","type":"simple_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","text":"Placebo","text_display":"Placebo","cell_row":5,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[244,2185],[1847,2185],[1847,2227],[244,2227]],"region":{"top_left_x":244,"top_left_y":2185,"width":1603,"height":42},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"587afa0b7b8c4ec9910c04a3772f357c","type":"table_spanning_cell","conversion_output":false,"parent_id":"1ac31484791e4ed3a4b450d22b795bff","children_ids":["2dfbe81e230a4b38b23acebaad1c8c6b"],"text":"","text_display":"Each cycle consists of 3 once-weekly i.a. injections of the specified dose over 3 consecutive weeks.","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":7},{"cnt":[[247,2185],[1630,2185],[1630,2227],[247,2227]],"region":{"top_left_x":246,"top_left_y":2185,"width":1385,"height":42},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2dfbe81e230a4b38b23acebaad1c8c6b","type":"simple_cell","conversion_output":false,"parent_id":"587afa0b7b8c4ec9910c04a3772f357c","text":"Each cycle consists of 3 once-weekly i.a. injections of the specified dose over 3 consecutive weeks.","text_display":"Each cycle consists of 3 once-weekly i.a. injections of the specified dose over 3 consecutive weeks.","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":7,"confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1880,2273],[1880,2327],[245,2327]],"region":{"top_left_x":244,"top_left_y":2273,"width":1636,"height":54},"line":94,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfdfedda8e1c41b08e3e12039a98e938","type":"text","conversion_output":true,"text":"The central randomization service's interactive voice response system (IVRS) will be used to","text_display":"\n\nThe central randomization service's interactive voice response system (IVRS) will be used to","confidence":1,"confidence_rate":1},{"cnt":[[245,2322],[1880,2322],[1880,2374],[245,2374]],"region":{"top_left_x":244,"top_left_y":2322,"width":1636,"height":53},"line":95,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5d58399fdf9453e9003478d339448ae","type":"text","conversion_output":true,"text":"randomize subjects and to assign a blinded treatment kit at each treatment visit, as described in","text_display":" randomize subjects and to assign a blinded treatment kit at each treatment visit, as described in","confidence":1,"confidence_rate":1},{"cnt":[[245,2372],[449,2372],[449,2417],[245,2417]],"region":{"top_left_x":244,"top_left_y":2371,"width":206,"height":46},"line":96,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d98b1a20c5cf4c8e89cf0c58fb5fdd37","type":"text","conversion_output":true,"text":"Section 6.3.","text_display":" Section 6.3.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1bd8b677e3745e092f9e0d967205569","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef55ce73290e48cbbf49259e8760785b","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72191fb0229c4ba1868d7f6e08820ffe","type":"page_info","conversion_output":false,"text":"47/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2608],[1796,2608]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":109},"line":100,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"8eefa24bed0e4e648dcd7783162b9fc7","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999186032298787}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-048","page":48,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"569c3f9699c7440b943c92d514d9fb39","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43681a7bb72e462fb949e4646490c48b","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d2228b24d0341ee984c0951df67a32f","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1296,279],[1296,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1052,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42057403b6374ef5a49fc9d77673b5e4","type":"text","conversion_output":true,"text":"Each treatment kit will include materials for a single injection.","text_display":"\n\nEach treatment kit will include materials for a single injection.","confidence":1,"confidence_rate":1},{"cnt":[[245,370],[1882,370],[1882,421],[245,421]],"region":{"top_left_x":244,"top_left_y":369,"width":1639,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b2d0fded5de49eb979db379d16eff1a","type":"text","conversion_output":true,"text":"All kits will include 1 glass vial of IMP (sprifermin or placebo) and 1 glass ampule of sterile","text_display":"\nAll kits will include 1 glass vial of IMP (sprifermin or placebo) and 1 glass ampule of sterile","confidence":0.9990234375,"confidence_rate":0.9999907826873115},{"cnt":[[245,417],[1811,417],[1811,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1568,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83c71bae1ad84e8ba979b818b7312db4","type":"text","conversion_output":true,"text":"saline solution for injection ( 2 mL per ampule) to be used for reconstitution (see Section 6.6).","text_display":" saline solution for injection ( 2 mL per ampule) to be used for reconstitution (see Section 6.6).","confidence":0.9839017355116084,"confidence_rate":0.9998483362759242},{"cnt":[[245,507],[1880,507],[1880,559],[245,559]],"region":{"top_left_x":244,"top_left_y":507,"width":1636,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8211c2337e144091b7370747bf7aa7b9","type":"text","conversion_output":true,"text":"Instructions for reconstitution are provided in the MOP. Once reconstituted, the IMP may remain","text_display":"\n\nInstructions for reconstitution are provided in the MOP. Once reconstituted, the IMP may remain","confidence":1,"confidence_rate":1},{"cnt":[[245,554],[1164,554],[1164,608],[245,608]],"region":{"top_left_x":244,"top_left_y":554,"width":921,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9603fbbcb72f4ae78f6571ad7207c3f6","type":"text","conversion_output":true,"text":"in the syringe for up to 2 hours prior to administration.","text_display":" in the syringe for up to 2 hours prior to administration.","confidence":1,"confidence_rate":1},{"cnt":[[243,645],[1880,645],[1880,698],[243,698]],"region":{"top_left_x":242,"top_left_y":644,"width":1638,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f86b636520b44b6982cbee5651f53ad","type":"text","conversion_output":true,"text":"The Investigator or a suitably qualified designee will administer the IMP. The exact time of IMP","text_display":"\n\nThe Investigator or a suitably qualified designee will administer the IMP. The exact time of IMP","confidence":0.99853515625,"confidence_rate":0.9999854860688677},{"cnt":[[245,692],[1038,692],[1038,741],[245,741]],"region":{"top_left_x":244,"top_left_y":691,"width":794,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df7248d313db4a89866ffdd1d0533e00","type":"text","conversion_output":true,"text":"administration will be documented in the CRF.","text_display":" administration will be documented in the CRF.","confidence":1,"confidence_rate":1},{"cnt":[[243,782],[1880,782],[1880,836],[243,836]],"region":{"top_left_x":242,"top_left_y":782,"width":1638,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95d9cdf6a064405fb667e75d6a66ad13","type":"text","conversion_output":true,"text":"I.a. administration of the IMP will be guided through the use of ultrasound to ensure delivery","text_display":"\nI.a. administration of the IMP will be guided through the use of ultrasound to ensure delivery","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,829],[1588,829],[1588,883],[245,883]],"region":{"top_left_x":244,"top_left_y":829,"width":1344,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c6afb10d55c469ea58562cca027d394","type":"text","conversion_output":true,"text":"into the joint space. Detailed instructions for injection are provided in the MOP.","text_display":" into the joint space. Detailed instructions for injection are provided in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,920],[1882,920],[1882,973],[245,973]],"region":{"top_left_x":244,"top_left_y":919,"width":1639,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12e292568ef1499285768b84a7884909","type":"text","conversion_output":true,"text":"Before injecting the IMP solution, an aspiration of the synovial fluid for local PK and biomarker","text_display":"\n\nBefore injecting the IMP solution, an aspiration of the synovial fluid for local PK and biomarker","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1880,967],[1880,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":966,"width":1636,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2ae9a4170c34675ac77829904ca7c31","type":"text","conversion_output":true,"text":"analysis will be performed as part of the i.a. injection procedure, using the same needle that will","text_display":" analysis will be performed as part of the i.a. injection procedure, using the same needle that will","confidence":1,"confidence_rate":1},{"cnt":[[245,1016],[1880,1016],[1880,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1016,"width":1636,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54e44170993944fb8eeac816c74d5ac4","type":"text","conversion_output":true,"text":"be used for IMP injection. If possible, up to 2.5 mL should be collected (instructions for sample","text_display":" be used for IMP injection. If possible, up to 2.5 mL should be collected (instructions for sample","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,1061],[849,1061],[849,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1061,"width":605,"height":59},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8857fdbed29a44ca9439b33e152c8744","type":"text","conversion_output":true,"text":"handling are provided in the MOP).","text_display":" handling are provided in the MOP).","confidence":1,"confidence_rate":1},{"cnt":[[245,1152],[1882,1152],[1882,1205],[245,1205]],"region":{"top_left_x":244,"top_left_y":1151,"width":1639,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc79f03b49b340aba93352ef094ce55a","type":"text","conversion_output":true,"text":"The volume of IMP solution to be injected will be 2 mL . The needle for injection will be flushed","text_display":"\n\nThe volume of IMP solution to be injected will be 2 mL . The needle for injection will be flushed","confidence":0.9946331977844238,"confidence_rate":0.9999497091596475},{"cnt":[[245,1199],[1882,1199],[1882,1253],[245,1253]],"region":{"top_left_x":244,"top_left_y":1198,"width":1639,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f464f7af6f984ab5a7d67d31224e61ab","type":"text","conversion_output":true,"text":"with 0.5 mL saline to make sure the entire dose has been injected (thus, the total volume injected","text_display":" with 0.5 mL saline to make sure the entire dose has been injected (thus, the total volume injected","confidence":1,"confidence_rate":1},{"cnt":[[245,1248],[522,1248],[522,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1248,"width":279,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ebc2f7681ea408e80047e3b66e5b45d","type":"text","conversion_output":true,"text":"will be 2.5 mL ).","text_display":" will be 2.5 mL ).","confidence":1,"confidence_rate":1},{"cnt":[[243,1336],[1882,1336],[1882,1390],[243,1390]],"region":{"top_left_x":242,"top_left_y":1336,"width":1641,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cacb6ba18dfb46c1b148d9140e8f4949","type":"text","conversion_output":true,"text":"At visits where samples are collected for PK analyses, subjects will be requested to stay in the","text_display":"\n\nAt visits where samples are collected for PK analyses, subjects will be requested to stay in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1386],[1764,1386],[1764,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1385,"width":1520,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97cd8963096446928cf8a9f96ae66558","type":"text","conversion_output":true,"text":"study site for approximately 2 hours post-injection for collection of the post-dose samples.","text_display":" study site for approximately 2 hours post-injection for collection of the post-dose samples.","confidence":0.99755859375,"confidence_rate":0.9999755563853322},{"cnt":[[236,1472],[1311,1472],[1311,1545],[236,1545]],"region":{"top_left_x":236,"top_left_y":1471,"width":1075,"height":74},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10fec487d50247beac9753e5c6cb9e84","type":"section_header","conversion_output":false,"children_ids":["61c05a4b063c4ed69a76eabf42c30be3","00530f7d60b84ca8830cb1c7059e0e1b"],"text":"","text_display":""},{"cnt":[[245,1478],[316,1478],[316,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1478,"width":72,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61c05a4b063c4ed69a76eabf42c30be3","type":"text","conversion_output":true,"parent_id":"10fec487d50247beac9753e5c6cb9e84","text":"6.3","text_display":"\n\n\\section*{6.3","confidence":1,"confidence_rate":1},{"cnt":[[593,1478],[1304,1478],[1304,1536],[593,1536]],"region":{"top_left_x":592,"top_left_y":1478,"width":713,"height":59},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00530f7d60b84ca8830cb1c7059e0e1b","type":"text","conversion_output":true,"parent_id":"10fec487d50247beac9753e5c6cb9e84","text":"Assignment to Treatment Groups","text_display":" Assignment to Treatment Groups}","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1886,1573],[1886,1626],[245,1626]],"region":{"top_left_x":244,"top_left_y":1572,"width":1643,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6572165b2174ac1833e0d416b042239","type":"text","conversion_output":true,"text":"Eligible subjects will be randomized to one of the 5 treatment groups with an allocation ratio of","text_display":"\n\nEligible subjects will be randomized to one of the 5 treatment groups with an allocation ratio of","confidence":0.99853515625,"confidence_rate":0.9999860389766703},{"cnt":[[245,1620],[1497,1620],[1497,1674],[245,1674]],"region":{"top_left_x":244,"top_left_y":1619,"width":1254,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c560a9a613f411391e2b28f97e9650a","type":"text","conversion_output":true,"text":"1:1:1:1:1. Statistical aspects of randomization are described in Section 8.2.","text_display":" 1:1:1:1:1. Statistical aspects of randomization are described in Section 8.2.","confidence":0.7999994279816747,"confidence_rate":0.9972824277623359},{"cnt":[[245,1710],[1880,1710],[1880,1764],[245,1764]],"region":{"top_left_x":244,"top_left_y":1710,"width":1636,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d27d0f1eb80404383b928c786d95d41","type":"text","conversion_output":true,"text":"The central randomization service's IVRS will be used to randomize subjects to treatment.","text_display":"\n\nThe central randomization service's IVRS will be used to randomize subjects to treatment.","confidence":1,"confidence_rate":1},{"cnt":[[245,1760],[1880,1760],[1880,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1759,"width":1636,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26c8d51ce08249bc85550b9ad289eac3","type":"text","conversion_output":true,"text":"Immediately prior to dosing, the Investigator or delegate will follow randomization procedures","text_display":" Immediately prior to dosing, the Investigator or delegate will follow randomization procedures","confidence":1,"confidence_rate":1},{"cnt":[[245,1807],[1790,1807],[1790,1861],[245,1861]],"region":{"top_left_x":244,"top_left_y":1806,"width":1546,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33cabfeae930470e90931f317c9cb0f3","type":"text","conversion_output":true,"text":"as explained in the MOP. The allocated randomization number will only be used for dosing.","text_display":" as explained in the MOP. The allocated randomization number will only be used for dosing.","confidence":1,"confidence_rate":1},{"cnt":[[245,1895],[1882,1895],[1882,1949],[245,1949]],"region":{"top_left_x":244,"top_left_y":1894,"width":1639,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e62fdd62e8ff43edb7a912da79506093","type":"text","conversion_output":true,"text":"The IVRS will also be used to assign a blinded treatment kit at each subsequent treatment visit","text_display":"\n\nThe IVRS will also be used to assign a blinded treatment kit at each subsequent treatment visit","confidence":1,"confidence_rate":1},{"cnt":[[245,1944],[887,1944],[887,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1944,"width":644,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"927dc12da29e4149825208dde2ef64f9","type":"text","conversion_output":true,"text":"(see Section 7.1.3.2 and Appendix E).","text_display":" (see Section 7.1.3.2 and Appendix E).","confidence":1,"confidence_rate":1},{"cnt":[[240,2100],[241,2028],[1345,2030],[1345,2102]],"region":{"top_left_x":240,"top_left_y":2028,"width":1106,"height":75},"line":32,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"35b0d7e4be6f47e09c4893427f2cde46","type":"section_header","conversion_output":false,"children_ids":["202609c356604bb185d37d4b9c44751a","2757772221344c3496f2899313245e48"],"text":"","text_display":""},{"cnt":[[243,2037],[316,2037],[316,2090],[243,2090]],"region":{"top_left_x":242,"top_left_y":2036,"width":74,"height":55},"line":33,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"202609c356604bb185d37d4b9c44751a","type":"text","conversion_output":true,"parent_id":"35b0d7e4be6f47e09c4893427f2cde46","text":"6.4","text_display":"\n\n\\section*{6.4","confidence":1,"confidence_rate":1},{"cnt":[[593,2037],[1338,2037],[1338,2095],[593,2095]],"region":{"top_left_x":592,"top_left_y":2036,"width":747,"height":59},"line":34,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"2757772221344c3496f2899313245e48","type":"text","conversion_output":true,"parent_id":"35b0d7e4be6f47e09c4893427f2cde46","text":"Other Drugs to be used in the Trial","text_display":" \\\\ Other Drugs to be used in the Trial}","confidence":0.9985356330871582,"confidence_rate":0.9999633646674417},{"cnt":[[245,2131],[1229,2131],[1229,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2131,"width":985,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3264c45fddc40378b0b5ee6b5d97fdd","type":"text","conversion_output":true,"text":"No other drugs will be provided in the context of this trial.","text_display":"\n\nNo other drugs will be provided in the context of this trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":36,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e506728468864064bff692d05b236b80","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":37,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6f2b389844284354879a85fbe3bae843","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fb469ee4191421e9effaaa07afe0202","type":"page_info","conversion_output":false,"text":"48/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-049","page":49,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6eb13a8fea540519e2263b810dcc7c7","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0e44c39c20a4e338408705af6879f0b","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"05569ddeb17944e28d47e783452a5fb4","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[1457,275],[1457,346],[241,346]],"region":{"top_left_x":240,"top_left_y":275,"width":1217,"height":71},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"361ed8e01d4f4376a3484e0021c2c748","type":"section_header","conversion_output":false,"children_ids":["67f90e4791484e4b9d7fa9b1821fa658"],"text":"","text_display":""},{"cnt":[[245,279],[1452,279],[1452,342],[245,342]],"region":{"top_left_x":244,"top_left_y":279,"width":1209,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67f90e4791484e4b9d7fa9b1821fa658","type":"text","conversion_output":true,"parent_id":"361ed8e01d4f4376a3484e0021c2c748","text":"6.5 Concomitant Medications and Therapies","text_display":"\n\n\\subsection*{6.5 Concomitant Medications and Therapies}","confidence":0.9692530632019043,"confidence_rate":0.9993213273144628},{"cnt":[[241,374],[1042,374],[1042,438],[241,438]],"region":{"top_left_x":240,"top_left_y":373,"width":802,"height":66},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33bc04beda8640429cf2ce37f57c969e","type":"section_header","conversion_output":false,"children_ids":["196975f8e74e44548c9a9fa7eb352c9c"],"text":"","text_display":""},{"cnt":[[245,380],[1038,380],[1038,432],[245,432]],"region":{"top_left_x":244,"top_left_y":380,"width":794,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"196975f8e74e44548c9a9fa7eb352c9c","type":"text","conversion_output":true,"parent_id":"33bc04beda8640429cf2ce37f57c969e","text":"6.5.1 Permitted Medicines","text_display":"\n\n\\subsection*{6.5.1 Permitted Medicines}","confidence":0.99951171875,"confidence_rate":0.9999837201159151},{"cnt":[[245,475],[1882,475],[1882,526],[245,526]],"region":{"top_left_x":244,"top_left_y":474,"width":1639,"height":53},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78b2ee4fc41340e6ae1e48faed480206","type":"text","conversion_output":true,"text":"Any medications (other than those excluded by the clinical trial protocol) that are considered","text_display":"\n\nAny medications (other than those excluded by the clinical trial protocol) that are considered","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,524],[1882,524],[1882,574],[245,574]],"region":{"top_left_x":244,"top_left_y":524,"width":1639,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d21149e5607a438aa0642e4f590a3c52","type":"text","conversion_output":true,"text":"necessary for the subjects' welfare and will not interfere with the trial medication may be given","text_display":" necessary for the subjects' welfare and will not interfere with the trial medication may be given","confidence":1,"confidence_rate":1},{"cnt":[[245,571],[769,571],[769,621],[245,621]],"region":{"top_left_x":244,"top_left_y":571,"width":526,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8460a18b68b34ddba3bc5364d360a82e","type":"text","conversion_output":true,"text":"at the Investigator's discretion.","text_display":" at the Investigator's discretion.","confidence":0.99951171875,"confidence_rate":0.9999871474379078},{"cnt":[[245,662],[1880,662],[1880,711],[245,711]],"region":{"top_left_x":244,"top_left_y":661,"width":1636,"height":51},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1372720521ac4cd5864eed39b60b8b5b","type":"text","conversion_output":true,"text":"The Investigator will record all concomitant medications taken by the subject during the trial,","text_display":"\n\nThe Investigator will record all concomitant medications taken by the subject during the trial,","confidence":1,"confidence_rate":1},{"cnt":[[245,709],[1680,709],[1680,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1437,"height":51},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4211c2de706c4e91bc9481e8aa57a5b8","type":"text","conversion_output":true,"text":"from the date of signature of informed consent, in the appropriate section of the CRF.","text_display":" from the date of signature of informed consent, in the appropriate section of the CRF.","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[1880,799],[1880,849],[245,849]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":50},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6718e51be3c5419c9f043562d0b959bf","type":"text","conversion_output":true,"text":"Any additional concomitant therapy that becomes necessary during the trial and any change to","text_display":"\n\nAny additional concomitant therapy that becomes necessary during the trial and any change to","confidence":1,"confidence_rate":1},{"cnt":[[245,846],[1880,846],[1880,896],[245,896]],"region":{"top_left_x":244,"top_left_y":846,"width":1636,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d58c8b6780e94534b677ee5c33f8f184","type":"text","conversion_output":true,"text":"concomitant medication must be recorded in the corresponding section of the CRF, noting the","text_display":" concomitant medication must be recorded in the corresponding section of the CRF, noting the","confidence":1,"confidence_rate":1},{"cnt":[[245,894],[1680,894],[1680,943],[245,943]],"region":{"top_left_x":244,"top_left_y":893,"width":1437,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9f1db3a58354cb187b36c647d9f8528","type":"text","conversion_output":true,"text":"name, dose, frequency of administration, duration, and indication of each medication.","text_display":" name, dose, frequency of administration, duration, and indication of each medication.","confidence":1,"confidence_rate":1},{"cnt":[[245,984],[1880,984],[1880,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":983,"width":1636,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b368d862ea784aba88c80c9ba5a1fdd4","type":"text","conversion_output":true,"text":"During the screening period, all analgesic medication must be withheld for 5 half-lives before the","text_display":"\n\nDuring the screening period, all analgesic medication must be withheld for 5 half-lives before the","confidence":1,"confidence_rate":1},{"cnt":[[245,1031],[1880,1031],[1880,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1031,"width":1636,"height":54},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a41235d2c444799bfecd795640a00b9","type":"text","conversion_output":true,"text":"screening (Visit 1b) and baseline WOMAC assessments. Aspirin (acetylsalicylic acid) used for","text_display":" screening (Visit 1b) and baseline WOMAC assessments. Aspirin (acetylsalicylic acid) used for","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1882,1079],[1882,1130],[245,1130]],"region":{"top_left_x":244,"top_left_y":1078,"width":1639,"height":53},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83d4195932454a6a87d2b844619d720d","type":"text","conversion_output":true,"text":"cardiovascular protection does not need to be withheld, nor do antidepressants used for","text_display":" cardiovascular protection does not need to be withheld, nor do antidepressants used for","confidence":1,"confidence_rate":1},{"cnt":[[245,1128],[909,1128],[909,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1127,"width":665,"height":53},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e034444d0e734e30a377af3894f77fb2","type":"text","conversion_output":true,"text":"management of OA pain or depression.","text_display":" management of OA pain or depression.","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1882,1216],[1882,1268],[245,1268]],"region":{"top_left_x":244,"top_left_y":1216,"width":1639,"height":52},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d370a753cf52412baaf8c517df85be4b","type":"text","conversion_output":true,"text":"Paracetamol (acetaminophen), NSAIDs including coxibs, and tramadol may be resumed","text_display":"\n\nParacetamol (acetaminophen), NSAIDs including coxibs, and tramadol may be resumed","confidence":1,"confidence_rate":1},{"cnt":[[245,1265],[1884,1265],[1884,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1265,"width":1641,"height":52},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fb1c2da06794024841eac22e6211177","type":"text","conversion_output":true,"text":"following randomization and continued as needed during the trial, except during the brief","text_display":" following randomization and continued as needed during the trial, except during the brief","confidence":1,"confidence_rate":1},{"cnt":[[245,1315],[1734,1315],[1734,1364],[245,1364]],"region":{"top_left_x":244,"top_left_y":1314,"width":1490,"height":51},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77fe66814d304c73a26358d106ce06cf","type":"text","conversion_output":true,"text":"analgesic withdrawal periods prior each study visit at which WOMAC data are obtained.","text_display":" analgesic withdrawal periods prior each study visit at which WOMAC data are obtained.","confidence":1,"confidence_rate":1},{"cnt":[[245,1403],[1880,1403],[1880,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1402,"width":1636,"height":53},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f53ad20277f4d7dafc2ebedd9decb22","type":"text","conversion_output":true,"text":"During the trial, paracetamol (acetaminophen) is recommended as rescue medication for the","text_display":"\n\nDuring the trial, paracetamol (acetaminophen) is recommended as rescue medication for the","confidence":1,"confidence_rate":1},{"cnt":[[245,1452],[1880,1452],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1452,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67433ecc66c44a419f447cd051fbdb5a","type":"text","conversion_output":true,"text":"treatment of breakthrough pain. The dosage of acetaminophen or paracetamol that the subjects","text_display":" treatment of breakthrough pain. The dosage of acetaminophen or paracetamol that the subjects","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":51},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e77624bf6dd34a9bb574b7e2dc3b38bb","type":"text","conversion_output":true,"text":"will be allowed to take per day will be defined according to the standard of care in the countries","text_display":" will be allowed to take per day will be defined according to the standard of care in the countries","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,1547],[1880,1547],[1880,1596],[245,1596]],"region":{"top_left_x":244,"top_left_y":1546,"width":1636,"height":51},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ccb6e5ef1bc4807b7a4e93bf57f064a","type":"text","conversion_output":true,"text":"where the trial will be carried out; however, the maximum dose should not exceed 1 gram per","text_display":" where the trial will be carried out; however, the maximum dose should not exceed 1 gram per","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1594],[1880,1594],[1880,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1594,"width":1636,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"911209a4f317430fbc248940b8f67976","type":"text","conversion_output":true,"text":"dose and 4 grams/day. Low-dose narcotics or combination products such as","text_display":" dose and 4 grams/day. Low-dose narcotics or combination products such as","confidence":1,"confidence_rate":1},{"cnt":[[245,1641],[1880,1641],[1880,1693],[245,1693]],"region":{"top_left_x":244,"top_left_y":1641,"width":1636,"height":52},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d75f0bca4db2422e96204b2a04b2aab9","type":"text","conversion_output":true,"text":"paracetamol/acetaminophen and oxycodone (Percocet) may be used only as needed for more","text_display":" paracetamol/acetaminophen and oxycodone (Percocet) may be used only as needed for more","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1880,1689],[1880,1740],[245,1740]],"region":{"top_left_x":244,"top_left_y":1688,"width":1636,"height":53},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85b5339411b34bb1bd1f3f253757d72c","type":"text","conversion_output":true,"text":"severe painful episodes. Duration of opioid use is limited to 14 days per episode. If the subject","text_display":" severe painful episodes. Duration of opioid use is limited to 14 days per episode. If the subject","confidence":1,"confidence_rate":1},{"cnt":[[245,1740],[1880,1740],[1880,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1740,"width":1636,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c99d349a5fd4ee9b23219de4692f9a9","type":"text","conversion_output":true,"text":"requires regular narcotic analgesia to control his/her arthritis pain, s/he should not be considered","text_display":" requires regular narcotic analgesia to control his/her arthritis pain, s/he should not be considered","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[449,1788],[449,1830],[245,1830]],"region":{"top_left_x":244,"top_left_y":1787,"width":206,"height":44},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"056913b27e62446d8349784d94abd242","type":"text","conversion_output":true,"text":"for the trial.","text_display":" for the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,1876],[1884,1876],[1884,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1875,"width":1641,"height":53},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"327d6a678e284a03a5d31c43df2bcb1b","type":"text","conversion_output":true,"text":"After the initial screening visit (Visit 1a), subjects will be requested to discontinue the intake of","text_display":"\n\nAfter the initial screening visit (Visit 1a), subjects will be requested to discontinue the intake of","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1880,1925],[1880,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1925,"width":1636,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e196d00c905c43b48e2fe93799bda14f","type":"text","conversion_output":true,"text":"all pain medications, including NSAIDs, coxibs, narcotics, and paracetamol (acetaminophen) for","text_display":" all pain medications, including NSAIDs, coxibs, narcotics, and paracetamol (acetaminophen) for","confidence":1,"confidence_rate":1},{"cnt":[[245,1972],[1880,1972],[1880,2022],[245,2022]],"region":{"top_left_x":244,"top_left_y":1972,"width":1636,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8351ab5fd6754bfc9b459de4ee501260","type":"text","conversion_output":true,"text":"at least 5 half-lives before a visit involving completion of the WOMAC, as described in Section","text_display":" at least 5 half-lives before a visit involving completion of the WOMAC, as described in Section","confidence":1,"confidence_rate":1},{"cnt":[[245,2020],[1880,2020],[1880,2069],[245,2069]],"region":{"top_left_x":244,"top_left_y":2019,"width":1636,"height":50},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6aafa86a45ae4af3a13b0c5b621e4983","type":"text","conversion_output":true,"text":"7.1.1. This is to ensure the most accurate assessment of pain and function, and is standard","text_display":" 7.1.1. This is to ensure the most accurate assessment of pain and function, and is standard","confidence":1,"confidence_rate":1},{"cnt":[[245,2067],[1880,2067],[1880,2118],[245,2118]],"region":{"top_left_x":244,"top_left_y":2066,"width":1636,"height":53},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64af317caef243229b26067f081a60b7","type":"text","conversion_output":true,"text":"practice in OA trials. Aspirin (acetylsalicylic acid) used for cardiovascular protection does not","text_display":" practice in OA trials. Aspirin (acetylsalicylic acid) used for cardiovascular protection does not","confidence":1,"confidence_rate":1},{"cnt":[[245,2116],[1783,2116],[1783,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2116,"width":1540,"height":52},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb1127e9a76945429357a6b73d23fe64","type":"text","conversion_output":true,"text":"need to be withheld, nor do antidepressants used for management of OA pain or depression.","text_display":" need to be withheld, nor do antidepressants used for management of OA pain or depression.","confidence":1,"confidence_rate":1},{"cnt":[[245,2204],[1880,2204],[1880,2254],[245,2254]],"region":{"top_left_x":244,"top_left_y":2204,"width":1636,"height":50},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b887932b9eea4e47a980d6f36ea0c63f","type":"text","conversion_output":true,"text":"Oral supplements such as glucosamine, diacerin, chondroitin sulfate may be used during the trial","text_display":"\n\nOral supplements such as glucosamine, diacerin, chondroitin sulfate may be used during the trial","confidence":1,"confidence_rate":1},{"cnt":[[245,2254],[1880,2254],[1880,2305],[245,2305]],"region":{"top_left_x":244,"top_left_y":2253,"width":1636,"height":53},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e167aaf02ec0484a84599cb7cc872e4f","type":"text","conversion_output":true,"text":"if they have been taken at a stable dose over at least 4 weeks prior to the first injection and are","text_display":" if they have been taken at a stable dose over at least 4 weeks prior to the first injection and are","confidence":1,"confidence_rate":1},{"cnt":[[245,2299],[1173,2299],[1173,2350],[245,2350]],"region":{"top_left_x":244,"top_left_y":2298,"width":930,"height":53},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e34151b09e24002b4b66266caad9ffb","type":"text","conversion_output":true,"text":"maintained at the same stable dose throughout the trial.","text_display":" maintained at the same stable dose throughout the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,2391],[1880,2391],[1880,2443],[245,2443]],"region":{"top_left_x":244,"top_left_y":2391,"width":1636,"height":52},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e23c80395354a9f9bde9afa602e2439","type":"text","conversion_output":true,"text":"Women of childbearing potential must use a method of contraception with a failure rate less than","text_display":"\n\nWomen of childbearing potential must use a method of contraception with a failure rate less than","confidence":0.9970703125,"confidence_rate":0.9999709510413867},{"cnt":[[245,2436],[1880,2436],[1880,2490],[245,2490]],"region":{"top_left_x":244,"top_left_y":2436,"width":1636,"height":55},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40e57f4b6c064ae3b18d1a28ddaef496","type":"text","conversion_output":true,"text":"\\(1 \\%\\) per year (as defined in the trial inclusion criteria; see Section 5.3.1) throughout the trial (i.e.,","text_display":" \\(1 \\%\\) per year (as defined in the trial inclusion criteria; see Section 5.3.1) throughout the trial (i.e.,","confidence":0.8556089401245117,"confidence_rate":0.9985436609982046},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3e20049b582a47be8c4e54668f233ce6","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2544],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":43},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8ec913d30950417ebcee43d434997048","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f8419ed6d754a93ae20742d493391f0","type":"page_info","conversion_output":false,"text":"49/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-050","page":50,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a1397a4eb6c45fc8c30b1e62ce85b61","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76d3f7ca51d14f7989e9da24c51ff8dd","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb5faea1a1894cba829da8bf05d55550","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a4395a80e024478ba3d7c3807b01575","type":"text","conversion_output":true,"text":"until the final extended follow-up visit). In case of premature withdrawal from the trial, there is","text_display":"\nuntil the final extended follow-up visit). In case of premature withdrawal from the trial, there is","confidence":1,"confidence_rate":1},{"cnt":[[245,327],[1394,327],[1394,380],[245,380]],"region":{"top_left_x":244,"top_left_y":326,"width":1151,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"604bf491e0984a368d10beb4aa1ab670","type":"text","conversion_output":true,"text":"no specific requirement for contraceptive use after the last trial visit.","text_display":" no specific requirement for contraceptive use after the last trial visit.","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1880,417],[1880,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"983ec73970cd4f948185cdd9243717e3","type":"text","conversion_output":true,"text":"Local anesthetic (e.g., lidocaine) is permitted prior to the injection of IMP at the investigator's","text_display":"\n\nLocal anesthetic (e.g., lidocaine) is permitted prior to the injection of IMP at the investigator's","confidence":1,"confidence_rate":1},{"cnt":[[245,466],[1880,466],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1636,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8119663059b41de820bdce48f13f1d7","type":"text","conversion_output":true,"text":"discretion according to the local standard of care. Anesthetic should not be administered intra-","text_display":" discretion according to the local standard of care. Anesthetic should not be administered intra","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,511],[629,511],[629,565],[245,565]],"region":{"top_left_x":244,"top_left_y":511,"width":386,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eac5371e75b345dbb07d34a913978005","type":"text","conversion_output":true,"text":"articularly at any time.","text_display":"articularly at any time.","confidence":1,"confidence_rate":1},{"cnt":[[241,602],[1141,602],[1141,668],[241,668]],"region":{"top_left_x":240,"top_left_y":601,"width":901,"height":68},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecf9325e16b74aebbe9877d06fe8b110","type":"section_header","conversion_output":false,"children_ids":["b0d3bd51419548158ca34c1c92c6e0a5"],"text":"","text_display":""},{"cnt":[[245,606],[1137,606],[1137,664],[245,664]],"region":{"top_left_x":244,"top_left_y":605,"width":893,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0d3bd51419548158ca34c1c92c6e0a5","type":"text","conversion_output":true,"parent_id":"ecf9325e16b74aebbe9877d06fe8b110","text":"6.5.2 Non-permitted Medicines","text_display":"\n\n\\subsection*{6.5.2 Non-permitted Medicines}","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1880,700],[1880,752],[245,752]],"region":{"top_left_x":244,"top_left_y":700,"width":1636,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d44817ea7524f679f3cb8cbd13904e4","type":"text","conversion_output":true,"text":"Subjects who have received i.a.corticosteroids or i.a. hyaluronic acid within the 6 months before","text_display":"\n\nSubjects who have received i.a.corticosteroids or i.a. hyaluronic acid within the 6 months before","confidence":0.7979924534565268,"confidence_rate":0.9978532015950442},{"cnt":[[245,748],[1880,748],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0e126c2bd5946c887f7c90f110e209a","type":"text","conversion_output":true,"text":"the beginning of screening will not be eligible for this trial, nor will subjects who are receiving","text_display":" the beginning of screening will not be eligible for this trial, nor will subjects who are receiving","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,797],[1880,797],[1880,849],[245,849]],"region":{"top_left_x":244,"top_left_y":797,"width":1636,"height":52},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06a809f4415b4441b76a04c169249db3","type":"text","conversion_output":true,"text":"concomitant treatment with oral corticosteroids or with a parenteral or oral anticoagulant,","text_display":" concomitant treatment with oral corticosteroids or with a parenteral or oral anticoagulant,","confidence":1,"confidence_rate":1},{"cnt":[[245,844],[1676,844],[1676,896],[245,896]],"region":{"top_left_x":244,"top_left_y":844,"width":1432,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"901b877cd59d47f5ac61583e0a26ca5b","type":"text","conversion_output":true,"text":"including heparin, coumadin/warfarin or their derivatives, or any other anticoagulant.","text_display":" including heparin, coumadin/warfarin or their derivatives, or any other anticoagulant.","confidence":1,"confidence_rate":1},{"cnt":[[245,932],[1880,932],[1880,986],[245,986]],"region":{"top_left_x":244,"top_left_y":932,"width":1636,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"451df4424eb144c190a6e2b9f734a63e","type":"text","conversion_output":true,"text":"Subjects who have taken part in another clinical trial within the 30 days (or 5 half-lives of the","text_display":"\n\nSubjects who have taken part in another clinical trial within the 30 days (or 5 half-lives of the","confidence":1,"confidence_rate":1},{"cnt":[[245,984],[1882,984],[1882,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":983,"width":1639,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a00a0e0448b7425d89e18e05645ce7ee","type":"text","conversion_output":true,"text":"investigated compound, whichever is longer) before the beginning of screening or in any","text_display":" investigated compound, whichever is longer) before the beginning of screening or in any","confidence":1,"confidence_rate":1},{"cnt":[[245,1031],[1038,1031],[1038,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1031,"width":794,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab460738710a4ba9bf652c53e09f7237","type":"text","conversion_output":true,"text":"previous trial of sprifermin will not be eligible.","text_display":" previous trial of sprifermin will not be eligible.","confidence":1,"confidence_rate":1},{"cnt":[[245,1117],[1880,1117],[1880,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1117,"width":1636,"height":54},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b557fc0fe8c440f19450d93a7613a7ef","type":"text","conversion_output":true,"text":"Use of the following medications is not permitted at any time during the trial (i.e., from signature","text_display":"\n\nUse of the following medications is not permitted at any time during the trial (i.e., from signature","confidence":0.9428987503051758,"confidence_rate":0.9994401913048666},{"cnt":[[245,1164],[1882,1164],[1882,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1164,"width":1639,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f7c7231289c483ca2be4903e6f0bed0","type":"text","conversion_output":true,"text":"of the Informed Consent Form (ICF) until the final trial visit (end of extended follow-up phase or","text_display":" of the Informed Consent Form (ICF) until the final trial visit (end of extended follow-up phase or","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[565,1216],[565,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":322,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5f47d020edd4f40baa21b14fe6c653b","type":"text","conversion_output":true,"text":"early termination):","text_display":" early termination):","confidence":1,"confidence_rate":1},{"cnt":[[245,1285],[1575,1285],[1575,1338],[245,1338]],"region":{"top_left_x":244,"top_left_y":1284,"width":1331,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3008eb6b9a364a81a1efcaf63c24e1ea","type":"text","conversion_output":true,"text":"- Intra-articular injection of corticosteroids or hyaluronic acid into either knee","text_display":"\n- Intra-articular injection of corticosteroids or hyaluronic acid into either knee","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[245,1358],[1446,1358],[1446,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1357,"width":1202,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c416487b70d4788b305ca77262bfca1","type":"text","conversion_output":true,"text":"- Long-term treatment (>14 days) with oral corticosteroids \\(>5 mg /\\) day","text_display":"\n- Long-term treatment (>14 days) with oral corticosteroids \\(>5 mg /\\) day","confidence":0.9449069825518379,"confidence_rate":0.9992829307931037},{"cnt":[[292,1427],[1882,1427],[1882,1480],[292,1480]],"region":{"top_left_x":292,"top_left_y":1426,"width":1591,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0267f28daeb0473b825f2a1701707ee2","type":"text","conversion_output":true,"text":"Note: However, the use of oral corticosteroids, \\(\\leq 5 mg /\\) day oral prednisone (or equivalent) for","text_display":"\n\nNote: However, the use of oral corticosteroids, \\(\\leq 5 mg /\\) day oral prednisone (or equivalent) for","confidence":0.9692530632019043,"confidence_rate":0.9996997610225493},{"cnt":[[294,1474],[1880,1474],[1880,1528],[294,1528]],"region":{"top_left_x":294,"top_left_y":1473,"width":1586,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d93eaa9ff5974203b0a514ad7cfd1563","type":"text","conversion_output":true,"text":"an indication other than OA pain during the trial will be allowed. In addition, short term use","text_display":" an indication other than OA pain during the trial will be allowed. In addition, short term use","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[294,1523],[1880,1523],[1880,1575],[294,1575]],"region":{"top_left_x":294,"top_left_y":1523,"width":1586,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3c86282f6ed43ba89a38ab3e0e3a66c","type":"text","conversion_output":true,"text":"of any tapering course of oral corticosteroids for \\(\\leq 14\\) days will be allowed. If oral","text_display":" of any tapering course of oral corticosteroids for \\(\\leq 14\\) days will be allowed. If oral","confidence":1,"confidence_rate":1},{"cnt":[[292,1573],[1880,1573],[1880,1622],[292,1622]],"region":{"top_left_x":292,"top_left_y":1572,"width":1588,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e686828d6194afbb9cd57cd6edcf94d","type":"text","conversion_output":true,"text":"corticosteroids \\(>5 mg /\\) day are used during the trial, efficacy assessments (e.g., WOMAC)","text_display":" corticosteroids \\(>5 mg /\\) day are used during the trial, efficacy assessments (e.g., WOMAC)","confidence":0.9936552047729492,"confidence_rate":0.9999350530378484},{"cnt":[[292,1620],[1858,1620],[1858,1671],[292,1671]],"region":{"top_left_x":292,"top_left_y":1619,"width":1567,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d8b3cfa236747ed8134da98be775415","type":"text","conversion_output":true,"text":"should not be scheduled until it has been at least 5 -half lives since completing the medication","text_display":" should not be scheduled until it has been at least 5 -half lives since completing the medication","confidence":0.93798828125,"confidence_rate":0.9993846334215809},{"cnt":[[245,1689],[1882,1689],[1882,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1688,"width":1639,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8182edf194a341cd9b4ce236a058f421","type":"text","conversion_output":true,"text":"- Any parenteral or oral anticoagulant, including heparin, coumadin/warfarin, or their","text_display":"\n- Any parenteral or oral anticoagulant, including heparin, coumadin/warfarin, or their","confidence":1,"confidence_rate":1},{"cnt":[[292,1740],[1156,1740],[1156,1790],[292,1790]],"region":{"top_left_x":292,"top_left_y":1740,"width":864,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a67845b05eeb4ef79866efc5e6a3ae6b","type":"text","conversion_output":true,"text":"derivatives, or any other anticoagulant medications","text_display":" derivatives, or any other anticoagulant medications","confidence":1,"confidence_rate":1},{"cnt":[[245,1811],[733,1811],[733,1863],[245,1863]],"region":{"top_left_x":244,"top_left_y":1811,"width":489,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ed1f18820434586be91d18e98661145","type":"text","conversion_output":true,"text":"- Any investigational agent","text_display":"\n- Any investigational agent","confidence":1,"confidence_rate":1},{"cnt":[[245,1899],[1880,1899],[1880,1951],[245,1951]],"region":{"top_left_x":244,"top_left_y":1899,"width":1636,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b28dcab7d6cf4c50bfd8d13021f32d2c","type":"text","conversion_output":true,"text":"If the administration of a non-permitted concomitant medication becomes necessary during the","text_display":"\n\nIf the administration of a non-permitted concomitant medication becomes necessary during the","confidence":1,"confidence_rate":1},{"cnt":[[245,1946],[1880,1946],[1880,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1946,"width":1636,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ac0d22c4c3f4c3bb057d1be664e65bf","type":"text","conversion_output":true,"text":"trial, e.g., because of AEs, treatment with the IMP will be discontinued and the subject will be","text_display":" trial, e.g., because of AEs, treatment with the IMP will be discontinued and the subject will be","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1996],[952,1996],[952,2047],[245,2047]],"region":{"top_left_x":244,"top_left_y":1995,"width":708,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"219d084bfa9d42bcb57ee84baf55dc5d","type":"text","conversion_output":true,"text":"followed up as described in Section 7.1.5.","text_display":" followed up as described in Section 7.1.5.","confidence":1,"confidence_rate":1},{"cnt":[[245,2084],[1880,2084],[1880,2138],[245,2138]],"region":{"top_left_x":244,"top_left_y":2083,"width":1636,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"490456c36cc64703808a869d5656feb2","type":"text","conversion_output":true,"text":"Subjects who receive any investigational treatment or participate in any other trial will be","text_display":"\n\nSubjects who receive any investigational treatment or participate in any other trial will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[681,2136],[681,2181],[245,2181]],"region":{"top_left_x":244,"top_left_y":2135,"width":438,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"265cb9701627482ea34d5ec90deea57d","type":"text","conversion_output":true,"text":"withdrawn from this trial.","text_display":" withdrawn from this trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,2221],[1880,2221],[1880,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2221,"width":1636,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"894e83abaf114596bf60cbccf8d5d5a7","type":"text","conversion_output":true,"text":"Any additional concomitant therapy that becomes necessary during the trial and any change to","text_display":"\n\nAny additional concomitant therapy that becomes necessary during the trial and any change to","confidence":1,"confidence_rate":1},{"cnt":[[245,2271],[1880,2271],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2270,"width":1636,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23bf28de2aa245d78ade7f018f65c4bd","type":"text","conversion_output":true,"text":"concomitant medications must be recorded in the corresponding section of the CRF, noting the","text_display":" concomitant medications must be recorded in the corresponding section of the CRF, noting the","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1680,2316],[1680,2370],[245,2370]],"region":{"top_left_x":244,"top_left_y":2316,"width":1437,"height":54},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6e8b6f40db14fe8af5f0c43f77e0c9a","type":"text","conversion_output":true,"text":"name, dose, frequency of administration, duration, and indication of each medication.","text_display":" name, dose, frequency of administration, duration, and indication of each medication.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e260220c4a334e14baacae0666dfe125","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2545],[389,2542],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2542,"width":146,"height":45},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c73c5c07a10e44608e9fa8ca5bd9a6cf","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65d4289da4034a44853f4bae26ed2721","type":"page_info","conversion_output":false,"text":"50/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2610],[1796,2610]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":111},"line":42,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"fa0cc60c606446298ad94e7066511c2d","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.9990234375,"confidence_rate":0.9998371733163992}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-051","page":51,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48ac889d507140debe76001d37207fb0","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0442e4b546214a41bdedf0bd572ffcac","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ee006cd3b8640488d066c536b22adb0","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,277],[1179,277],[1179,339],[241,339]],"region":{"top_left_x":240,"top_left_y":277,"width":940,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5629478238c74a9eb439e6be03f2dd21","type":"section_header","conversion_output":false,"children_ids":["2645e0764fca4484abe1d94f10b0b980"],"text":"","text_display":""},{"cnt":[[245,281],[1173,281],[1173,333],[245,333]],"region":{"top_left_x":244,"top_left_y":281,"width":930,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2645e0764fca4484abe1d94f10b0b980","type":"text","conversion_output":true,"parent_id":"5629478238c74a9eb439e6be03f2dd21","text":"6.5.3 Other Trial Considerations","text_display":"\n\n\\subsection*{6.5.3 Other Trial Considerations}","confidence":0.99755859375,"confidence_rate":0.9999339375513608},{"cnt":[[241,374],[741,374],[741,436],[241,436]],"region":{"top_left_x":240,"top_left_y":373,"width":502,"height":64},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecfa88fb177b439b990482dedddd7323","type":"section_header","conversion_output":false,"children_ids":["21acbb96e9b64125956e0c13597b508c"],"text":"","text_display":""},{"cnt":[[245,378],[737,378],[737,432],[245,432]],"region":{"top_left_x":244,"top_left_y":378,"width":493,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21acbb96e9b64125956e0c13597b508c","type":"text","conversion_output":true,"parent_id":"ecfa88fb177b439b990482dedddd7323","text":"Other Permitted Therapies","text_display":"\n\n\\section*{Other Permitted Therapies}","confidence":1,"confidence_rate":1},{"cnt":[[245,468],[1882,468],[1882,518],[245,518]],"region":{"top_left_x":244,"top_left_y":468,"width":1639,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f3d6ac4b733498882491c491a8305b1","type":"text","conversion_output":true,"text":"Patient education and physical or occupational therapy (e.g., assisting device for walking, diet","text_display":"\n\nPatient education and physical or occupational therapy (e.g., assisting device for walking, diet","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1274,516],[1274,569],[245,569]],"region":{"top_left_x":244,"top_left_y":515,"width":1031,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f90501b20f24130b36630c418be8f82","type":"text","conversion_output":true,"text":"for weight loss, muscle-strengthening exercises) are allowed.","text_display":" for weight loss, muscle-strengthening exercises) are allowed.","confidence":1,"confidence_rate":1},{"cnt":[[241,602],[831,602],[831,664],[241,664]],"region":{"top_left_x":240,"top_left_y":601,"width":592,"height":63},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a44d9c4318440268b0f27aa81f0190d","type":"section_header","conversion_output":false,"children_ids":["725901550af54236a35838fb46de8008"],"text":"","text_display":""},{"cnt":[[245,606],[827,606],[827,660],[245,660]],"region":{"top_left_x":244,"top_left_y":605,"width":584,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"725901550af54236a35838fb46de8008","type":"text","conversion_output":true,"parent_id":"1a44d9c4318440268b0f27aa81f0190d","text":"Other Non-Permitted Therapies","text_display":"\n\n\\section*{Other Non-Permitted Therapies}","confidence":1,"confidence_rate":1},{"cnt":[[245,694],[1618,694],[1618,746],[245,746]],"region":{"top_left_x":244,"top_left_y":693,"width":1374,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66b371a62d5d4055a8e864902a11e2c3","type":"text","conversion_output":true,"text":"Interventional or diagnostic arthroscopy affecting the target knee is not permitted.","text_display":"\n\nInterventional or diagnostic arthroscopy affecting the target knee is not permitted.","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[245,782],[1882,782],[1882,836],[245,836]],"region":{"top_left_x":244,"top_left_y":782,"width":1639,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b3773b8a5934c8db2a63f3bc69912db","type":"text","conversion_output":true,"text":"Use of electrotherapy (e.g., transcutaneous electrical stimulation) or acupuncture for OA","text_display":"\nUse of electrotherapy (e.g., transcutaneous electrical stimulation) or acupuncture for OA","confidence":1,"confidence_rate":1},{"cnt":[[245,834],[941,834],[941,883],[245,883]],"region":{"top_left_x":244,"top_left_y":833,"width":698,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fbbc593421b4dffb3d230835331812d","type":"text","conversion_output":true,"text":"affecting the target knee is not permitted.","text_display":" affecting the target knee is not permitted.","confidence":1,"confidence_rate":1},{"cnt":[[245,920],[1882,920],[1882,973],[245,973]],"region":{"top_left_x":244,"top_left_y":919,"width":1639,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c70f835e9fa405eaf61c3edf4358b25","type":"text","conversion_output":true,"text":"If any of these procedures are used during the trial, treatment with the IMP will be discontinued","text_display":"\n\nIf any of these procedures are used during the trial, treatment with the IMP will be discontinued","confidence":1,"confidence_rate":1},{"cnt":[[245,971],[1336,971],[1336,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":971,"width":1093,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac71442acf2d45a2b89c1e82f85c16f6","type":"text","conversion_output":true,"text":"and the subject will be followed up as described in Section 7.1.5.","text_display":" and the subject will be followed up as described in Section 7.1.5.","confidence":1,"confidence_rate":1},{"cnt":[[240,1124],[241,1054],[1016,1056],[1016,1126]],"region":{"top_left_x":240,"top_left_y":1053,"width":777,"height":74},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b64f3a1ae03742d197d1c79dabdbca9d","type":"section_header","conversion_output":false,"children_ids":["6915c58f783f4b1c8b3a2751113040d6"],"text":"","text_display":""},{"cnt":[[245,1061],[1012,1061],[1012,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1061,"width":768,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6915c58f783f4b1c8b3a2751113040d6","type":"text","conversion_output":true,"parent_id":"b64f3a1ae03742d197d1c79dabdbca9d","text":"6.5.4 Special Precautions","text_display":"\n\n\\subsection*{6.5.4 Special Precautions}","confidence":0.99951171875,"confidence_rate":0.9999837201159151},{"cnt":[[245,1156],[1824,1156],[1824,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1155,"width":1581,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a99ea642887481db77a17b429ab0b82","type":"text","conversion_output":true,"text":"No special precautions are necessary beyond those applicable to i.a. administration in general.","text_display":"\n\nNo special precautions are necessary beyond those applicable to i.a. administration in general.","confidence":0.9897596772071893,"confidence_rate":0.9998970741410508},{"cnt":[[241,1244],[1115,1244],[1115,1313],[241,1313]],"region":{"top_left_x":240,"top_left_y":1243,"width":876,"height":70},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d72845366aa43da8f6487e97cac9dba","type":"section_header","conversion_output":false,"children_ids":["dcd88dafd23a433ab3d2686bca5bf44d"],"text":"","text_display":""},{"cnt":[[245,1250],[1109,1250],[1109,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1250,"width":865,"height":59},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dcd88dafd23a433ab3d2686bca5bf44d","type":"text","conversion_output":true,"parent_id":"2d72845366aa43da8f6487e97cac9dba","text":"6.6 Packaging and Labeling","text_display":"\n\n\\subsection*{6.6 Packaging and Labeling}","confidence":0.56591796875,"confidence_rate":0.9818028895139913},{"cnt":[[245,1343],[1755,1343],[1755,1396],[245,1396]],"region":{"top_left_x":244,"top_left_y":1342,"width":1512,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07a722496c8147e596fdfecacea9da81","type":"text","conversion_output":true,"text":"IMP (sprifermin and placebo) will be provided in glass vials as described in Section 6.1.1.","text_display":"\n\nIMP (sprifermin and placebo) will be provided in glass vials as described in Section 6.1.1.","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,1433],[1880,1433],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1433,"width":1636,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3d38c7d69f445e38d5c188abb35f25c","type":"text","conversion_output":true,"text":"Packaging and labeling will be identical for placebo and active medication to ensure the blinded","text_display":"\nPackaging and labeling will be identical for placebo and active medication to ensure the blinded","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1880,1482],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1482,"width":1636,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c34818ce459245118a9582059d5fb550","type":"text","conversion_output":true,"text":"nature of the trial, and will be in accordance with applicable local regulatory requirements and","text_display":" nature of the trial, and will be in accordance with applicable local regulatory requirements and","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1485,1530],[1485,1583],[245,1583]],"region":{"top_left_x":244,"top_left_y":1529,"width":1241,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b89b9514f1e443d986eaec228bdeeac6","type":"text","conversion_output":true,"text":"applicable GMP guidelines and with the storage requirements of the IMP.","text_display":" applicable GMP guidelines and with the storage requirements of the IMP.","confidence":1,"confidence_rate":1},{"cnt":[[245,1618],[1880,1618],[1880,1669],[245,1669]],"region":{"top_left_x":244,"top_left_y":1617,"width":1636,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"acef12a9d4374665a1bcf51bbbccef10","type":"text","conversion_output":true,"text":"Vials of IMP will come in kits as described in Section 6.2. All kits will contain 1 vial of IMP","text_display":"\n\nVials of IMP will come in kits as described in Section 6.2. All kits will contain 1 vial of IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[1594,1667],[1594,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1667,"width":1351,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"262bdedc0e084e39979e97a894aa2f17","type":"text","conversion_output":true,"text":"(sprifermin or placebo) and 1 ampule of sterile saline solution for reconstitution:","text_display":" (sprifermin or placebo) and 1 ampule of sterile saline solution for reconstitution:","confidence":0.9970722198486328,"confidence_rate":0.9999677799203567},{"cnt":[[245,1738],[1878,1738],[1878,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1738,"width":1634,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8f9cb6370b249898f9d4f0d80b3983b","type":"text","conversion_output":true,"text":"- Kits for 30 mcg treatments will contain 1 glass vial of sprifermin ( 30 mcg strength) and 1","text_display":"\n- Kits for 30 mcg treatments will contain 1 glass vial of sprifermin ( 30 mcg strength) and 1","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[294,1788],[1467,1788],[1467,1841],[294,1841]],"region":{"top_left_x":294,"top_left_y":1787,"width":1174,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5f08002ccb64d049ba13a604f009b7c","type":"text","conversion_output":true,"text":"glass ampule of sterile saline solution for injection ( 2 mL per ampule)","text_display":" glass ampule of sterile saline solution for injection ( 2 mL per ampule)","confidence":0.9498705184087157,"confidence_rate":0.9993730063977054},{"cnt":[[245,1858],[1876,1858],[1876,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1858,"width":1632,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4419a12a48784776ab38166675b09b75","type":"text","conversion_output":true,"text":"- Kits for 100 mcg treatments will contain 1 glass vial of sprifermin ( 100 mcg strength) and 1","text_display":"\n- Kits for 100 mcg treatments will contain 1 glass vial of sprifermin ( 100 mcg strength) and 1","confidence":0.993172641611352,"confidence_rate":0.9999388342686736},{"cnt":[[294,1908],[1470,1908],[1470,1962],[294,1962]],"region":{"top_left_x":294,"top_left_y":1907,"width":1176,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e65e64ae8274316892a68b6bad19ea3","type":"text","conversion_output":true,"text":"glass ampule of sterile saline solution for injection ( 2 mL per ampule)","text_display":" glass ampule of sterile saline solution for injection ( 2 mL per ampule)","confidence":0.9718321524560452,"confidence_rate":0.9996516195754914},{"cnt":[[245,1979],[1880,1979],[1880,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1978,"width":1636,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88edd9f61f674626a3906556008f3bf7","type":"text","conversion_output":true,"text":"- Kits for placebo treatments will contain 1 glass vial of placebo and 1 glass ampule of sterile","text_display":"\n- Kits for placebo treatments will contain 1 glass vial of placebo and 1 glass ampule of sterile","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[292,2028],[1085,2028],[1085,2082],[292,2082]],"region":{"top_left_x":292,"top_left_y":2028,"width":793,"height":54},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9ca0b29359942db847a6d1e9db1dc1f","type":"text","conversion_output":true,"text":"saline solution for injection ( 2 mL per ampule)","text_display":" saline solution for injection ( 2 mL per ampule)","confidence":0.9722800254821777,"confidence_rate":0.9995154377149259},{"cnt":[[241,2114],[1343,2114],[1343,2185],[241,2185]],"region":{"top_left_x":240,"top_left_y":2114,"width":1103,"height":71},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0c546372152440293e0ecd9228e3ef1","type":"section_header","conversion_output":false,"children_ids":["aaea78f221b94b5181eb95c2c4a3a652"],"text":"","text_display":""},{"cnt":[[245,2118],[1343,2118],[1343,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2118,"width":1099,"height":59},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aaea78f221b94b5181eb95c2c4a3a652","type":"text","conversion_output":true,"parent_id":"e0c546372152440293e0ecd9228e3ef1","text":"6.7 Preparation, Handling and Storage","text_display":"\n\n\\subsection*{6.7 Preparation, Handling and Storage}","confidence":0.9877986907958984,"confidence_rate":0.999700621499515},{"cnt":[[245,2213],[1717,2213],[1717,2264],[245,2264]],"region":{"top_left_x":244,"top_left_y":2212,"width":1473,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d33206807a144219021c9d08dc765fd","type":"text","conversion_output":true,"text":"Preparation and administration of the IMP are described in Section 6.2 and in the MOP.","text_display":"\n\nPreparation and administration of the IMP are described in Section 6.2 and in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,2303],[1852,2303],[1852,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2303,"width":1608,"height":54},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcf58968ac92477190e114b1ef1764b0","type":"text","conversion_output":true,"text":"Once reconstituted, the IMP may remain in the syringe for up to 2 hours prior to administration.","text_display":"\nOnce reconstituted, the IMP may remain in the syringe for up to 2 hours prior to administration.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1a171578786e4624866ce2a36f257fae","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"772bd3984aa44a0cb84cdc7f749e34ca","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0f6bbaf3e24413087b3afceeff6936c","type":"page_info","conversion_output":false,"text":"51/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1897,2501],[1897,2597],[1796,2597]],"region":{"top_left_x":1796,"top_left_y":2500,"width":102,"height":98},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b8849f25817f4e798a57aa8f710e6215","type":"page_info","conversion_output":false,"text":"\\(\\sqrt{A} \\sqrt{L}\\)","text_display":"","confidence":0.13944068047788588,"confidence_rate":0.8485923737269772}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-052","page":52,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9be60338b16048e3a0fda586c33369bf","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71d51a942fea4bffad46a13f85d5c076","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1be961881f3409dae64b79a87f373a7","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a97d1587348a48448f1feb43d6ebe02b","type":"text","conversion_output":true,"text":"The IMP must be stored at ambient temperature ( \\(<25^{\\circ} C\\); do not freeze) in a locked dispensary,","text_display":"\n\nThe IMP must be stored at ambient temperature ( \\(<25^{\\circ} C\\); do not freeze) in a locked dispensary,","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1882,329],[1882,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1639,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dbcddfb3780491f8f66908bb125446d","type":"text","conversion_output":true,"text":"with a temperature log maintained daily. It will be transferred to the clinical unit when needed","text_display":" with a temperature log maintained daily. It will be transferred to the clinical unit when needed","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,378],[812,378],[812,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":569,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f6c1c943b6f487fb4eee322b8a58e29","type":"text","conversion_output":true,"text":"for administration to the subjects.","text_display":" for administration to the subjects.","confidence":1,"confidence_rate":1},{"cnt":[[243,466],[320,466],[320,522],[243,522]],"region":{"top_left_x":242,"top_left_y":466,"width":79,"height":57},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4e2de7002834fd78a5c174c8c5eb851","type":"section_header","conversion_output":false,"children_ids":["2192ad76d56c477a8a8722bff5d62089"],"text":"","text_display":""},{"cnt":[[245,468],[316,468],[316,518],[245,518]],"region":{"top_left_x":244,"top_left_y":468,"width":72,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2192ad76d56c477a8a8722bff5d62089","type":"text","conversion_output":true,"parent_id":"c4e2de7002834fd78a5c174c8c5eb851","text":"6.8","text_display":"\n\n\\section*{6.8}","confidence":1,"confidence_rate":1},{"cnt":[[589,464],[1635,464],[1635,531],[589,531]],"region":{"top_left_x":588,"top_left_y":464,"width":1047,"height":67},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef07aa22d5e3401e8c1ddd81b1206af6","type":"section_header","conversion_output":false,"children_ids":["9e20b7180e8a474fb2f91b21bb92db8f"],"text":"","text_display":""},{"cnt":[[593,468],[1631,468],[1631,526],[593,526]],"region":{"top_left_x":592,"top_left_y":468,"width":1039,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e20b7180e8a474fb2f91b21bb92db8f","type":"text","conversion_output":true,"parent_id":"ef07aa22d5e3401e8c1ddd81b1206af6","text":"Investigational Medicinal Product Accountability","text_display":"\n\n\\section*{Investigational Medicinal Product Accountability}","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1884,563],[1884,612],[245,612]],"region":{"top_left_x":244,"top_left_y":562,"width":1641,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b01e407cbec4c2494da478647651e62","type":"text","conversion_output":true,"text":"The Investigator is responsible for ensuring accountability for IMP, including reconciliation of","text_display":"\n\nThe Investigator is responsible for ensuring accountability for IMP, including reconciliation of","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[913,610],[913,664],[245,664]],"region":{"top_left_x":244,"top_left_y":610,"width":670,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd9f148f746043e1ab89441adb29916b","type":"text","conversion_output":true,"text":"drugs and maintenance of drug records.","text_display":" drugs and maintenance of drug records.","confidence":1,"confidence_rate":1},{"cnt":[[245,683],[1880,683],[1880,733],[245,733]],"region":{"top_left_x":244,"top_left_y":683,"width":1636,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e4621f135f04008a33258e18a8fa6f6","type":"text","conversion_output":true,"text":"- Upon receipt of IMP, the Investigator (or designee) will check for accurate delivery and","text_display":"\n- Upon receipt of IMP, the Investigator (or designee) will check for accurate delivery and","confidence":1,"confidence_rate":1},{"cnt":[[294,730],[1880,730],[1880,782],[294,782]],"region":{"top_left_x":294,"top_left_y":730,"width":1586,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d558320c4adb4414928d4cbfeb65eefb","type":"text","conversion_output":true,"text":"acknowledge receipt by signing (or initialing) and dating the documentation provided by the","text_display":" acknowledge receipt by signing (or initialing) and dating the documentation provided by the","confidence":1,"confidence_rate":1},{"cnt":[[294,778],[1880,778],[1880,829],[294,829]],"region":{"top_left_x":294,"top_left_y":777,"width":1586,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5657a78c2db0422d92d4a3df342c4be5","type":"text","conversion_output":true,"text":"distribution center and returning it to the distribution center. A copy will be retained for the","text_display":" distribution center and returning it to the distribution center. A copy will be retained for the","confidence":1,"confidence_rate":1},{"cnt":[[294,827],[587,827],[587,879],[294,879]],"region":{"top_left_x":294,"top_left_y":827,"width":293,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95ae5a2a7cb14ab8978d715e186fd1e3","type":"text","conversion_output":true,"text":"Investigator File.","text_display":" Investigator File.","confidence":1,"confidence_rate":1},{"cnt":[[245,898],[1880,898],[1880,952],[245,952]],"region":{"top_left_x":244,"top_left_y":898,"width":1636,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93672e51f38c4255b381cd940fd8f78a","type":"text","conversion_output":true,"text":"- The dispensing of the IMP will be carefully recorded on the appropriate drug accountability","text_display":"\n- The dispensing of the IMP will be carefully recorded on the appropriate drug accountability","confidence":1,"confidence_rate":1},{"cnt":[[294,947],[1880,947],[1880,999],[294,999]],"region":{"top_left_x":294,"top_left_y":947,"width":1586,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56edbb5e9a624a839d7c437bac5ce7b4","type":"text","conversion_output":true,"text":"forms provided by the Monitor and an accurate accounting will be available for verification","text_display":" forms provided by the Monitor and an accurate accounting will be available for verification","confidence":1,"confidence_rate":1},{"cnt":[[292,993],[969,993],[969,1046],[292,1046]],"region":{"top_left_x":292,"top_left_y":992,"width":677,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e578a5d9518419f94d73b376efdce5e","type":"text","conversion_output":true,"text":"by the Monitor at each monitoring visit.","text_display":" by the Monitor at each monitoring visit.","confidence":1,"confidence_rate":1},{"cnt":[[245,1066],[975,1066],[975,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1065,"width":732,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f50e28545c2470597b30c60c1cef337","type":"text","conversion_output":true,"text":"- IMP accountability records will include:","text_display":"\n- IMP accountability records will include:","confidence":1,"confidence_rate":1},{"cnt":[[294,1139],[1113,1139],[1113,1188],[294,1188]],"region":{"top_left_x":294,"top_left_y":1138,"width":819,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f075f96c3711439e83c2abee550e5de6","type":"text","conversion_output":true,"text":"- Confirmation of IMP delivery to the trial site.","text_display":"\n- Confirmation of IMP delivery to the trial site.","confidence":0.99951171875,"confidence_rate":0.9999909555872323},{"cnt":[[294,1210],[1880,1210],[1880,1261],[294,1261]],"region":{"top_left_x":294,"top_left_y":1209,"width":1586,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b16e34e061e64da384e1afeb671523b6","type":"text","conversion_output":true,"text":"- The inventory at the site of IMP provided by the distribution center and prepared at the","text_display":"\n- The inventory at the site of IMP provided by the distribution center and prepared at the","confidence":1,"confidence_rate":1},{"cnt":[[344,1259],[421,1259],[421,1302],[344,1302]],"region":{"top_left_x":343,"top_left_y":1258,"width":79,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad460a5cee24464da6656a7405ce478f","type":"text","conversion_output":true,"text":"site.","text_display":" site.","confidence":1,"confidence_rate":1},{"cnt":[[294,1328],[1094,1328],[1094,1381],[294,1381]],"region":{"top_left_x":294,"top_left_y":1327,"width":800,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab1158c444da41a8b9755e5fd751569b","type":"text","conversion_output":true,"text":"- Administration of each dose to each subject.","text_display":"\n- Administration of each dose to each subject.","confidence":1,"confidence_rate":1},{"cnt":[[294,1401],[1639,1401],[1639,1452],[294,1452]],"region":{"top_left_x":294,"top_left_y":1400,"width":1346,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4261f4645f5f43709aca360afd4558bb","type":"text","conversion_output":true,"text":"- The return to the distribution center or alternative disposition of unused IMP.","text_display":"\n- The return to the distribution center or alternative disposition of unused IMP.","confidence":1,"confidence_rate":1},{"cnt":[[294,1474],[1880,1474],[1880,1525],[294,1525]],"region":{"top_left_x":294,"top_left_y":1473,"width":1586,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bf1c17df8ad4bc695a29fa8b6e53420","type":"text","conversion_output":true,"text":"- Dates, quantities, batch numbers, expiry dates and (for IMP prepared at the site)","text_display":"\n- Dates, quantities, batch numbers, expiry dates and (for IMP prepared at the site)","confidence":1,"confidence_rate":1},{"cnt":[[344,1521],[1195,1521],[1195,1571],[344,1571]],"region":{"top_left_x":343,"top_left_y":1521,"width":852,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"136d6b65f74d4406b7a0fcccc302e036","type":"text","conversion_output":true,"text":"formulation, as well as the subjects' trial numbers.","text_display":" formulation, as well as the subjects' trial numbers.","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1437,1594],[1437,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1594,"width":1194,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f66a6dbc3552405fb5281a8d3461f64f","type":"text","conversion_output":true,"text":"- The Investigator should maintain records that adequately document:","text_display":"\n- The Investigator should maintain records that adequately document:","confidence":1,"confidence_rate":1},{"cnt":[[294,1663],[1880,1663],[1880,1717],[294,1717]],"region":{"top_left_x":294,"top_left_y":1662,"width":1586,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eb5e7ffab74487489e642ef9fdec4ec","type":"text","conversion_output":true,"text":"- That the subjects were administered the doses specified by the clinical trial","text_display":"\n- That the subjects were administered the doses specified by the clinical trial","confidence":1,"confidence_rate":1},{"cnt":[[344,1712],[827,1712],[827,1764],[344,1764]],"region":{"top_left_x":343,"top_left_y":1712,"width":485,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edfe35d713654046916f09314a12c74e","type":"text","conversion_output":true,"text":"protocol/amendment(s), and","text_display":" protocol/amendment(s), and","confidence":1,"confidence_rate":1},{"cnt":[[294,1783],[1515,1783],[1515,1837],[294,1837]],"region":{"top_left_x":294,"top_left_y":1783,"width":1221,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1adcf31407bd421c8ccc0022cd8697c5","type":"text","conversion_output":true,"text":"- That all IMP provided by the distribution center was fully reconciled.","text_display":"\n- That all IMP provided by the distribution center was fully reconciled.","confidence":1,"confidence_rate":1},{"cnt":[[245,1873],[1884,1873],[1884,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1873,"width":1641,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c5780cfba464bc0bdbe67bd2650c4e2","type":"text","conversion_output":true,"text":"Unused IMP must not be discarded or used for any purpose other than the present trial. IMP that","text_display":"\n\nUnused IMP must not be discarded or used for any purpose other than the present trial. IMP that","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1566,1921],[1566,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1920,"width":1323,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dadaa2e037464782b7fb19ce150cb546","type":"text","conversion_output":true,"text":"has been dispensed to a subject must not be re-dispensed to a different subject.","text_display":" has been dispensed to a subject must not be re-dispensed to a different subject.","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1880,2011],[1880,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2010,"width":1636,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a2be944e99347cab27462fd04629e85","type":"text","conversion_output":true,"text":"The Monitor will periodically collect the IMP accountability forms and will check all returns","text_display":"\n\nThe Monitor will periodically collect the IMP accountability forms and will check all returns","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1882,2058],[1882,2110],[245,2110]],"region":{"top_left_x":244,"top_left_y":2058,"width":1639,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67969c389f8f45c09d10480a1e6662ff","type":"text","conversion_output":true,"text":"(both unused and used containers) before arranging for their return to the distribution center or","text_display":" (both unused and used containers) before arranging for their return to the distribution center or","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[995,2105],[995,2159],[245,2159]],"region":{"top_left_x":244,"top_left_y":2105,"width":751,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cde0271c659e4a2bab49881d216e2a6a","type":"text","conversion_output":true,"text":"authorizing their destruction by the trial site.","text_display":" authorizing their destruction by the trial site.","confidence":0.99853515625,"confidence_rate":0.9999723415583037},{"cnt":[[241,2196],[320,2196],[320,2254],[241,2254]],"region":{"top_left_x":240,"top_left_y":2195,"width":81,"height":59},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa3f3bb5cf424be6b2de27fb12d86c75","type":"section_header","conversion_output":false,"children_ids":["a9c11509ab21403ca70ccb1b8b2269f4"],"text":"","text_display":""},{"cnt":[[245,2200],[316,2200],[316,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2200,"width":72,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9c11509ab21403ca70ccb1b8b2269f4","type":"text","conversion_output":true,"parent_id":"aa3f3bb5cf424be6b2de27fb12d86c75","text":"6.9","text_display":"\n\n\\section*{6.9}","confidence":1,"confidence_rate":1},{"cnt":[[589,2194],[1882,2194],[1882,2262],[589,2262]],"region":{"top_left_x":588,"top_left_y":2193,"width":1295,"height":70},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a67c29b19b843bd89e0e6ba28ebbec6","type":"section_header","conversion_output":false,"children_ids":["b2a51d2418764bd897ed7dfe0ad3654c"],"text":"","text_display":""},{"cnt":[[593,2200],[1876,2200],[1876,2256],[593,2256]],"region":{"top_left_x":592,"top_left_y":2200,"width":1284,"height":56},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2a51d2418764bd897ed7dfe0ad3654c","type":"text","conversion_output":true,"parent_id":"9a67c29b19b843bd89e0e6ba28ebbec6","text":"Assessment of Investigational Medicinal Product Compliance","text_display":"\n\n\\section*{Assessment of Investigational Medicinal Product Compliance}","confidence":0.99951171875,"confidence_rate":0.9999922476411908},{"cnt":[[245,2295],[1880,2295],[1880,2344],[245,2344]],"region":{"top_left_x":244,"top_left_y":2294,"width":1636,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b4573c095514ad1955d5d4bb7594eb9","type":"text","conversion_output":true,"text":"The Investigator or a suitably qualified designee will administer the IMP. IMP administration","text_display":"\n\nThe Investigator or a suitably qualified designee will administer the IMP. IMP administration","confidence":0.9985356330871582,"confidence_rate":0.9999850466409257},{"cnt":[[245,2342],[746,2342],[746,2387],[245,2387]],"region":{"top_left_x":244,"top_left_y":2341,"width":502,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4cc58b400eec4b7882ec4aa20c6fd979","type":"text","conversion_output":true,"text":"must be recorded in the CRF.","text_display":" must be recorded in the CRF.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6a3a5a47b529486fb61d13d49ef9563b","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"30fb32214eac48dbac60fcb1c2598cb3","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58ed6af0839b40f8b4b341cb9f528e5b","type":"page_info","conversion_output":false,"text":"52/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-053","page":53,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bdb57fec850e43e58442e68b6e65169a","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c8afb30f5004034bc8fe85ea4e325cc","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c361bc9ebed4254a6e7333f8ed261fb","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[1016,275],[1016,346],[241,346]],"region":{"top_left_x":240,"top_left_y":275,"width":777,"height":71},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a8285eb6c5f472a888ed545fa3e46c3","type":"section_header","conversion_output":false,"children_ids":["232a5c89faa34c9e934bea2dbfc0c213"],"text":"","text_display":""},{"cnt":[[245,284],[1012,284],[1012,342],[245,342]],"region":{"top_left_x":244,"top_left_y":283,"width":768,"height":59},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"232a5c89faa34c9e934bea2dbfc0c213","type":"text","conversion_output":true,"parent_id":"1a8285eb6c5f472a888ed545fa3e46c3","text":"6.10 Method of Blinding","text_display":"\n\n\\subsection*{6.10 Method of Blinding}","confidence":0.9853966236114502,"confidence_rate":0.9994552945062153},{"cnt":[[245,378],[1880,378],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":1636,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f1722b54fad4c6f8364bb8eba8ad50f","type":"text","conversion_output":true,"text":"The Sponsor will supply active sprifermin and placebo in glass vials which will be visually","text_display":"\n\nThe Sponsor will supply active sprifermin and placebo in glass vials which will be visually","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,425],[1882,425],[1882,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1639,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d03af01d731418a86edbf2d258aa233","type":"text","conversion_output":true,"text":"identical. Packaging and labeling will be identical for placebo and active medication (see Section","text_display":" identical. Packaging and labeling will be identical for placebo and active medication (see Section","confidence":1,"confidence_rate":1},{"cnt":[[245,475],[329,475],[329,524],[245,524]],"region":{"top_left_x":244,"top_left_y":474,"width":85,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e01dbb1fe7ac44c39e1dbd778a635657","type":"text","conversion_output":true,"text":"6.6).","text_display":" 6.6).","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a055a651cab40e6aa617623ef9fc0ae","type":"text","conversion_output":true,"text":"At each trial visit at which IMP is administered, the central randomization service's IVRS will be","text_display":"\n\nAt each trial visit at which IMP is administered, the central randomization service's IVRS will be","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1880,610],[1880,662],[245,662]],"region":{"top_left_x":244,"top_left_y":610,"width":1636,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbd7658a96b24ff1b7cb909d39d33e7a","type":"text","conversion_output":true,"text":"used to obtain a blinded treatment kit number corresponding to the subject's randomized","text_display":" used to obtain a blinded treatment kit number corresponding to the subject's randomized","confidence":1,"confidence_rate":1},{"cnt":[[245,657],[1882,657],[1882,709],[245,709]],"region":{"top_left_x":244,"top_left_y":657,"width":1639,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31b45e609ee045648047818f4c92f7b6","type":"text","conversion_output":true,"text":"treatment (see Section 6.3). The subject will then be treated with the medication from that","text_display":" treatment (see Section 6.3). The subject will then be treated with the medication from that","confidence":1,"confidence_rate":1},{"cnt":[[245,707],[483,707],[483,754],[245,754]],"region":{"top_left_x":244,"top_left_y":706,"width":240,"height":49},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08798e4a88364145818a9967d0e5bc6f","type":"text","conversion_output":true,"text":"numbered kit.","text_display":" numbered kit.","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[1880,795],[1880,849],[245,849]],"region":{"top_left_x":244,"top_left_y":794,"width":1636,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3111c740664d4ea5bad2f68c85685230","type":"text","conversion_output":true,"text":"All kits will include 1 glass vial of IMP (sprifermin or placebo) and 1 glass ampule of sterile","text_display":"\n\nAll kits will include 1 glass vial of IMP (sprifermin or placebo) and 1 glass ampule of sterile","confidence":0.9990234375,"confidence_rate":0.9999907826873115},{"cnt":[[245,844],[1880,844],[1880,896],[245,896]],"region":{"top_left_x":244,"top_left_y":844,"width":1636,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e9fd70224574a01a3cf307c925d4d1e","type":"text","conversion_output":true,"text":"saline solution for injection ( 2 mL per ampule) to be used for reconstitution (see Section 6.6).","text_display":" saline solution for injection ( 2 mL per ampule) to be used for reconstitution (see Section 6.6).","confidence":0.9936552047729492,"confidence_rate":0.9999405157039609},{"cnt":[[245,889],[1880,889],[1880,943],[245,943]],"region":{"top_left_x":244,"top_left_y":889,"width":1636,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"310255ae9be9411991c471b4fe043cbf","type":"text","conversion_output":true,"text":"Reconstitution of IMP and preparation of injections will be identical for all treatments","text_display":" Reconstitution of IMP and preparation of injections will be identical for all treatments","confidence":1,"confidence_rate":1},{"cnt":[[245,939],[1171,939],[1171,993],[245,993]],"region":{"top_left_x":244,"top_left_y":938,"width":927,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d411cedfb6349719b84b3a5ec2cf5b7","type":"text","conversion_output":true,"text":"(sprifermin 100 mcg , sprifermin 30 mcg , and placebo).","text_display":" (sprifermin 100 mcg , sprifermin 30 mcg , and placebo).","confidence":0.99951171875,"confidence_rate":0.9999930228743673},{"cnt":[[241,1027],[1096,1027],[1096,1098],[241,1098]],"region":{"top_left_x":240,"top_left_y":1026,"width":856,"height":72},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"253addf0c9f1457ba3a6577f43042420","type":"section_header","conversion_output":false,"children_ids":["4b8d5599a0604a85acbbac4ff3206d35"],"text":"","text_display":""},{"cnt":[[245,1033],[1089,1033],[1089,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1033,"width":846,"height":57},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b8d5599a0604a85acbbac4ff3206d35","type":"text","conversion_output":true,"parent_id":"253addf0c9f1457ba3a6577f43042420","text":"6.11 Emergency Unblinding","text_display":"\n\n\\subsection*{6.11 Emergency Unblinding}","confidence":0.99951171875,"confidence_rate":0.999983158745329},{"cnt":[[245,1128],[1880,1128],[1880,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1127,"width":1636,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29fe00c0ff084d9a9266ac797398c07b","type":"text","conversion_output":true,"text":"The trial blind may be broken for an individual subject only in the case of an emergency when","text_display":"\n\nThe trial blind may be broken for an individual subject only in the case of an emergency when","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1882,1177],[1882,1227],[245,1227]],"region":{"top_left_x":244,"top_left_y":1177,"width":1639,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e868729b2df24bc497bf3209243a75fc","type":"text","conversion_output":true,"text":"knowledge of the IMP is essential for the clinical management of the subject. The Investigator","text_display":" knowledge of the IMP is essential for the clinical management of the subject. The Investigator","confidence":1,"confidence_rate":1},{"cnt":[[245,1225],[1558,1225],[1558,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1224,"width":1314,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06dfc82061124dbfb6459cfd8ef47fca","type":"text","conversion_output":true,"text":"must make every effort to contact the Sponsor prior to breaking the trial blind.","text_display":" must make every effort to contact the Sponsor prior to breaking the trial blind.","confidence":1,"confidence_rate":1},{"cnt":[[245,1313],[1880,1313],[1880,1364],[245,1364]],"region":{"top_left_x":244,"top_left_y":1312,"width":1636,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ed42c722e47430b925fa27aca3363f5","type":"text","conversion_output":true,"text":"If it is not possible to contact the Sponsor, the Investigator will be able to access the subject's","text_display":"\n\nIf it is not possible to contact the Sponsor, the Investigator will be able to access the subject's","confidence":0.9970722198486328,"confidence_rate":0.9999718073735385},{"cnt":[[245,1362],[1880,1362],[1880,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1362,"width":1636,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58e18d90bc5f4d1a99c26aad1c11d5aa","type":"text","conversion_output":true,"text":"treatment assignment 24 hours a day through the IVRS system, using specific procedures defined","text_display":" treatment assignment 24 hours a day through the IVRS system, using specific procedures defined","confidence":1,"confidence_rate":1},{"cnt":[[245,1409],[458,1409],[458,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1409,"width":214,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00a2f62c35b74c54bc0214dbd8adead3","type":"text","conversion_output":true,"text":"in the MOP.","text_display":" in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,1497],[1882,1497],[1882,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1497,"width":1639,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a80b93cff4924067befb2e2a129b7d33","type":"text","conversion_output":true,"text":"Contact information for breaking the blind in an emergency will also be provided on the subject","text_display":"\n\nContact information for breaking the blind in an emergency will also be provided on the subject","confidence":1,"confidence_rate":1},{"cnt":[[245,1547],[1270,1547],[1270,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1546,"width":1026,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e594c8952a2f4426a564cfa9a431337b","type":"text","conversion_output":true,"text":"emergency card handed out to each subject (see Section 9.4).","text_display":" emergency card handed out to each subject (see Section 9.4).","confidence":1,"confidence_rate":1},{"cnt":[[245,1635],[1880,1635],[1880,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1634,"width":1636,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccd1f2d5f9cc405baabfe6aac13030fe","type":"text","conversion_output":true,"text":"If the blind is broken, the Investigator must inform the Sponsor immediately without revealing to","text_display":"\n\nIf the blind is broken, the Investigator must inform the Sponsor immediately without revealing to","confidence":1,"confidence_rate":1},{"cnt":[[245,1684],[1880,1684],[1880,1734],[245,1734]],"region":{"top_left_x":244,"top_left_y":1684,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c596ae055b1342c886f3dfb8cdec621b","type":"text","conversion_output":true,"text":"the Sponsor personnel the result of the code break. The Investigator must record in the subject's","text_display":" the Sponsor personnel the result of the code break. The Investigator must record in the subject's","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,1732],[1880,1732],[1880,1781],[245,1781]],"region":{"top_left_x":244,"top_left_y":1731,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db4d5594488d45118185a59133feb086","type":"text","conversion_output":true,"text":"CRF the date of unblinding and the reason for unblinding. Code breaks performed at a place","text_display":" CRF the date of unblinding and the reason for unblinding. Code breaks performed at a place","confidence":1,"confidence_rate":1},{"cnt":[[245,1779],[1214,1779],[1214,1830],[245,1830]],"region":{"top_left_x":244,"top_left_y":1778,"width":970,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4ae4be4b1334f23b188f4e5be76a212","type":"text","conversion_output":true,"text":"other than the trial site will also be documented carefully.","text_display":" other than the trial site will also be documented carefully.","confidence":0.99951171875,"confidence_rate":0.9999924861744118},{"cnt":[[245,1869],[1882,1869],[1882,1921],[245,1921]],"region":{"top_left_x":244,"top_left_y":1869,"width":1639,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16588394d821411fa2a0fdfacdb05e87","type":"text","conversion_output":true,"text":"If emergency unblinding is required, discontinuation of the affected subject from the trial is not","text_display":"\n\nIf emergency unblinding is required, discontinuation of the affected subject from the trial is not","confidence":0.99853515625,"confidence_rate":0.9999857678907678},{"cnt":[[245,1916],[1652,1916],[1652,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1916,"width":1409,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5ca8a45cff749acb3b5b52a5861a1ac","type":"text","conversion_output":true,"text":"mandatory unless there are other circumstances that require subject discontinuation.","text_display":" mandatory unless there are other circumstances that require subject discontinuation.","confidence":1,"confidence_rate":1},{"cnt":[[241,2002],[1096,2002],[1096,2067],[241,2067]],"region":{"top_left_x":240,"top_left_y":2002,"width":856,"height":65},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"908b41c528934849b473cb3eec79733e","type":"section_header","conversion_output":false,"children_ids":["9844a93f13b04633b6d95e5873dab1f3"],"text":"","text_display":""},{"cnt":[[245,2011],[1089,2011],[1089,2060],[245,2060]],"region":{"top_left_x":244,"top_left_y":2010,"width":846,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9844a93f13b04633b6d95e5873dab1f3","type":"text","conversion_output":true,"parent_id":"908b41c528934849b473cb3eec79733e","text":"6.12 Treatment of Overdose","text_display":"\n\n\\subsection*{6.12 Treatment of Overdose}","confidence":0.9892780780792236,"confidence_rate":0.9996407373529259},{"cnt":[[245,2103],[1880,2103],[1880,2155],[245,2155]],"region":{"top_left_x":244,"top_left_y":2103,"width":1636,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d9dadc7b6e1443a93634345ff0ebb05","type":"text","conversion_output":true,"text":"An overdose is defined as any dose greater than the highest daily dose included in the clinical","text_display":"\n\nAn overdose is defined as any dose greater than the highest daily dose included in the clinical","confidence":0.9980475902557373,"confidence_rate":0.9999804570091607},{"cnt":[[245,2153],[1884,2153],[1884,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2152,"width":1641,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73cce1e55bdf462cb825d7adfa72d4b2","type":"text","conversion_output":true,"text":"trial protocol (i.e., 100 mcg ). Any overdose must be recorded in the trial medication section of","text_display":" trial protocol (i.e., 100 mcg ). Any overdose must be recorded in the trial medication section of","confidence":0.9761457149870694,"confidence_rate":0.9997743861502368},{"cnt":[[245,2200],[406,2200],[406,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2200,"width":163,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17877c317a4744339acfe332ad1964c3","type":"text","conversion_output":true,"text":"the CRF.","text_display":" the CRF.","confidence":0.99951171875,"confidence_rate":0.9999624314366309},{"cnt":[[245,2290],[1880,2290],[1880,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2290,"width":1636,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5bab1fd1be54ca28510da616f8f267b","type":"text","conversion_output":true,"text":"For monitoring purposes, any case of overdose - whether or not associated with an AE (serious","text_display":"\n\nFor monitoring purposes, any case of overdose - whether or not associated with an AE (serious","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,2338],[1880,2338],[1880,2391],[245,2391]],"region":{"top_left_x":244,"top_left_y":2337,"width":1636,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18b5d0f084ad410e949709d1b899564a","type":"text","conversion_output":true,"text":"or non-serious) - must be reported to the Sponsor's Global Drug Safety (GDS) department in an","text_display":" or non-serious) - must be reported to the Sponsor's Global Drug Safety (GDS) department in an","confidence":1,"confidence_rate":1},{"cnt":[[245,2385],[1532,2385],[1532,2438],[245,2438]],"region":{"top_left_x":244,"top_left_y":2384,"width":1288,"height":55},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e1707998bbc4892a9dc83c9144ac3f4","type":"text","conversion_output":true,"text":"expedited manner using the appropriate reporting form (see Section 7.4.1.4).","text_display":" expedited manner using the appropriate reporting form (see Section 7.4.1.4).","confidence":0.96484375,"confidence_rate":0.9995582567596143},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"adfcb56d0deb45ab9a537fdfd6765b8b","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2544],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":43},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b9d67896f7c94415bbdb30f85970b00d","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17fb8b977eea4828896687d94af8c4c7","type":"page_info","conversion_output":false,"text":"53/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-054","page":54,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3cbc1889032d44d58af83696bded6311","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"166c2fbacca344df9e99b7fe915a091c","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ade43c8d1c2142b58aae255f547b0f3c","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3119b8be846340a3bc898504706e2b28","type":"text","conversion_output":true,"text":"The effects of an overdose of sprifermin are unknown, and there is no known specific treatment","text_display":"\n\nThe effects of an overdose of sprifermin are unknown, and there is no known specific treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1882,329],[1882,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1639,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"885dfa3898f24beca06f3b40965a12d4","type":"text","conversion_output":true,"text":"in case of overdose. In the event of overdose, subjects should be closely monitored and managed","text_display":" in case of overdose. In the event of overdose, subjects should be closely monitored and managed","confidence":0.9990234375,"confidence_rate":0.999990229651252},{"cnt":[[245,378],[1072,378],[1072,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":829,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d0ba492c44f49718d037aad03a336c1","type":"text","conversion_output":true,"text":"according to the Investigator's clinical judgment.","text_display":" according to the Investigator's clinical judgment.","confidence":0.99853515625,"confidence_rate":0.9999733473064166},{"cnt":[[241,464],[1515,464],[1515,531],[241,531]],"region":{"top_left_x":240,"top_left_y":464,"width":1275,"height":67},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7d9605e987c4b45820d1625cf6411de","type":"section_header","conversion_output":false,"children_ids":["44525845e19d43e887107332a2a2a059","61d4d8a1be874eb58229d6d31c6a772e"],"text":"","text_display":""},{"cnt":[[245,468],[337,468],[337,518],[245,518]],"region":{"top_left_x":244,"top_left_y":468,"width":94,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44525845e19d43e887107332a2a2a059","type":"text","conversion_output":true,"parent_id":"e7d9605e987c4b45820d1625cf6411de","text":"6.13","text_display":"\n\n\\subsection*{6.13","confidence":1,"confidence_rate":1},{"cnt":[[593,468],[1510,468],[1510,526],[593,526]],"region":{"top_left_x":592,"top_left_y":468,"width":919,"height":59},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61d4d8a1be874eb58229d6d31c6a772e","type":"text","conversion_output":true,"parent_id":"e7d9605e987c4b45820d1625cf6411de","text":"Medical Care of Subjects after End of Trial","text_display":" Medical Care of Subjects after End of Trial}","confidence":0.99560546875,"confidence_rate":0.9999082497179616},{"cnt":[[245,563],[1880,563],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bef19715b744ebf8cfa59c9f179cf42","type":"text","conversion_output":true,"text":"Subjects who have completed the trial or have withdrawn early should be managed in accordance","text_display":"\n\nSubjects who have completed the trial or have withdrawn early should be managed in accordance","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,610],[1880,610],[1880,664],[245,664]],"region":{"top_left_x":244,"top_left_y":610,"width":1636,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e17b42549e14effabf75acdecaec81d","type":"text","conversion_output":true,"text":"with the Investigator's clinical judgment, as appropriate for each subject's individual medical","text_display":" with the Investigator's clinical judgment, as appropriate for each subject's individual medical","confidence":0.99755859375,"confidence_rate":0.9999755563853322},{"cnt":[[245,662],[359,662],[359,707],[245,707]],"region":{"top_left_x":244,"top_left_y":661,"width":115,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9184c675572c45349c2a1da59e5a2a81","type":"text","conversion_output":true,"text":"needs.","text_display":" needs.","confidence":1,"confidence_rate":1},{"cnt":[[241,748],[1321,748],[1321,806],[241,806]],"region":{"top_left_x":240,"top_left_y":747,"width":1082,"height":59},"line":13,"column":0,"font_size":40,"is_printed":true,"is_handwritten":false,"id":"7b986fabef694f8a893c3e1373865082","type":"section_header","conversion_output":false,"children_ids":["cd415f76ea0a410ebee5eca89bc679dd","bc70eaff5bb049978f7b3131dba8a90a"],"text":"","text_display":""},{"cnt":[[243,743],[279,743],[279,799],[243,799]],"region":{"top_left_x":242,"top_left_y":743,"width":38,"height":57},"line":14,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"cd415f76ea0a410ebee5eca89bc679dd","type":"text","conversion_output":true,"parent_id":"7b986fabef694f8a893c3e1373865082","text":"7","text_display":"\n\n\\section*{7","confidence":1,"confidence_rate":1},{"cnt":[[593,752],[1315,752],[1315,801],[593,801]],"region":{"top_left_x":592,"top_left_y":751,"width":723,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc70eaff5bb049978f7b3131dba8a90a","type":"text","conversion_output":true,"parent_id":"7b986fabef694f8a893c3e1373865082","text":"Trial Procedures and Assessments","text_display":" Trial Procedures and Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[245,846],[1880,846],[1880,896],[245,896]],"region":{"top_left_x":244,"top_left_y":846,"width":1636,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb5cf3cae4084d7d82a07a3afc8cebf5","type":"text","conversion_output":true,"text":"Outlines of trial procedures and assessments are presented in Section 7.1. Procedures and","text_display":"\n\nOutlines of trial procedures and assessments are presented in Section 7.1. Procedures and","confidence":1,"confidence_rate":1},{"cnt":[[245,894],[1880,894],[1880,947],[245,947]],"region":{"top_left_x":244,"top_left_y":893,"width":1636,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"335a8962c231428db575c8251b86d9ea","type":"text","conversion_output":true,"text":"assessments are described in more detail in Sections 7.2 (baseline characteristics), 7.3 (efficacy),","text_display":" assessments are described in more detail in Sections 7.2 (baseline characteristics), 7.3 (efficacy),","confidence":1,"confidence_rate":1},{"cnt":[[245,941],[1880,941],[1880,993],[245,993]],"region":{"top_left_x":244,"top_left_y":941,"width":1636,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"004d65be74394bc4b984ff089f9dac3f","type":"text","conversion_output":true,"text":"7.4 (safety), 7.5 (PK), 7.6 (biomarkers), and 7.7 (assessment of health-related QOL and OA","text_display":" 7.4 (safety), 7.5 (PK), 7.6 (biomarkers), and 7.7 (assessment of health-related QOL and OA","confidence":1,"confidence_rate":1},{"cnt":[[245,993],[348,993],[348,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":992,"width":105,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e2d50b3d77544a08e374ecc71002bed","type":"text","conversion_output":true,"text":"pain).","text_display":" pain).","confidence":1,"confidence_rate":1},{"cnt":[[241,1079],[1115,1079],[1115,1137],[241,1137]],"region":{"top_left_x":240,"top_left_y":1078,"width":876,"height":59},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb9bf843bd3645dabc7da1568b6c452a","type":"section_header","conversion_output":false,"children_ids":["6e187775afd24d3fb264e92a980fd431"],"text":"","text_display":""},{"cnt":[[245,1083],[1111,1083],[1111,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1082,"width":867,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e187775afd24d3fb264e92a980fd431","type":"text","conversion_output":true,"parent_id":"cb9bf843bd3645dabc7da1568b6c452a","text":"7.1 Schedule of Assessments","text_display":"\n\n\\subsection*{7.1 Schedule of Assessments}","confidence":0.541015625,"confidence_rate":0.9809859933355376},{"cnt":[[245,1177],[1880,1177],[1880,1227],[245,1227]],"region":{"top_left_x":244,"top_left_y":1177,"width":1636,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"993dc84c06c548e192b2f6584a6e64a3","type":"text","conversion_output":true,"text":"The trial will consist of a screening period, a DBPC treatment phase (which will begin with","text_display":"\n\nThe trial will consist of a screening period, a DBPC treatment phase (which will begin with","confidence":1,"confidence_rate":1},{"cnt":[[245,1225],[1880,1225],[1880,1276],[245,1276]],"region":{"top_left_x":244,"top_left_y":1224,"width":1636,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a803e1349bd54eebaa08af806a96e3fa","type":"text","conversion_output":true,"text":"randomization and initiation of therapy at Week 0/Visit 2), and an extended follow-up phase (see","text_display":" randomization and initiation of therapy at Week 0/Visit 2), and an extended follow-up phase (see","confidence":1,"confidence_rate":1},{"cnt":[[245,1274],[855,1274],[855,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1274,"width":612,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72eb0137f26e44ae95f913e0514204b2","type":"text","conversion_output":true,"text":"Section 5.1, Figure 1, and Figure 2).","text_display":" Section 5.1, Figure 1, and Figure 2).","confidence":1,"confidence_rate":1},{"cnt":[[245,1362],[1880,1362],[1880,1414],[245,1414]],"region":{"top_left_x":244,"top_left_y":1362,"width":1636,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecc1ea7b48c140bda6842104e1f81c5c","type":"text","conversion_output":true,"text":"General instructions and procedures to be performed throughout the trial are described in Section","text_display":"\n\nGeneral instructions and procedures to be performed throughout the trial are described in Section","confidence":1,"confidence_rate":1},{"cnt":[[245,1412],[1880,1412],[1880,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1411,"width":1636,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc05fcf31be44290a7dc974efb4e086f","type":"text","conversion_output":true,"text":"7.1.1, and outlines of the visits included in each of the trial phases are presented in Sections 7.1.2","text_display":" 7.1.1, and outlines of the visits included in each of the trial phases are presented in Sections 7.1.2","confidence":0.9990234375,"confidence_rate":0.9999908688300274},{"cnt":[[245,1457],[1734,1457],[1734,1510],[245,1510]],"region":{"top_left_x":244,"top_left_y":1456,"width":1490,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a0b87cb23a5420fbdd7d0711e3aebd0","type":"text","conversion_output":true,"text":"(screening period), 7.1.3 (DBPC treatment phase), and 7.1.4 (extended follow-up phase).","text_display":" (screening period), 7.1.3 (DBPC treatment phase), and 7.1.4 (extended follow-up phase).","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,1547],[1880,1547],[1880,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1546,"width":1636,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3b6532df07d475eb13b120ae1bd1b9c","type":"text","conversion_output":true,"text":"The procedures to be performed at each trial visit are presented in the Schedule of Trial","text_display":"\n\nThe procedures to be performed at each trial visit are presented in the Schedule of Trial","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,1594],[700,1594],[700,1648],[245,1648]],"region":{"top_left_x":244,"top_left_y":1594,"width":457,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13430f7beb00487cae4a1e084e48e786","type":"text","conversion_output":true,"text":"Procedures in Appendix E.","text_display":" Procedures in Appendix E.","confidence":1,"confidence_rate":1},{"cnt":[[243,1684],[1038,1684],[1038,1742],[243,1742]],"region":{"top_left_x":242,"top_left_y":1684,"width":796,"height":59},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81b05ff6e39142aba77eebb28da45570","type":"section_header","conversion_output":false,"children_ids":["17aee2b394f44a6eb569de47641002d1"],"text":"","text_display":""},{"cnt":[[247,1689],[1033,1689],[1033,1738],[247,1738]],"region":{"top_left_x":247,"top_left_y":1688,"width":787,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17aee2b394f44a6eb569de47641002d1","type":"text","conversion_output":true,"parent_id":"81b05ff6e39142aba77eebb28da45570","text":"7.1.1 General Instructions","text_display":"\n\n\\subsection*{7.1.1 General Instructions}","confidence":0.99951171875,"confidence_rate":0.9999842452693294},{"cnt":[[243,1783],[587,1783],[587,1833],[243,1833]],"region":{"top_left_x":242,"top_left_y":1783,"width":345,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d7c9d7be67f47a8b41dc4443275760f","type":"section_header","conversion_output":false,"children_ids":["268d5c6637644b36b5ed6c03e3f52745"],"text":"","text_display":""},{"cnt":[[245,1788],[582,1788],[582,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1787,"width":339,"height":42},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"268d5c6637644b36b5ed6c03e3f52745","type":"text","conversion_output":true,"parent_id":"3d7c9d7be67f47a8b41dc4443275760f","text":"Informed Consent","text_display":"\n\n\\section*{Informed Consent}","confidence":1,"confidence_rate":1},{"cnt":[[245,1873],[1880,1873],[1880,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1873,"width":1636,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd7dd0a5915349638b83a139dd46de02","type":"text","conversion_output":true,"text":"Prior to performing any trial assessments not part of the subject's routine medical care, the","text_display":"\n\nPrior to performing any trial assessments not part of the subject's routine medical care, the","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1880,1921],[1880,1972],[245,1972]],"region":{"top_left_x":244,"top_left_y":1920,"width":1636,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7153d11feb4546dd926ff4a116d49ab9","type":"text","conversion_output":true,"text":"Investigator will ensure that the subject or the subject's legal representative has provided written","text_display":" Investigator will ensure that the subject or the subject's legal representative has provided written","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1420,1968],[1420,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1967,"width":1177,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7c9521ca05546a9a1a22e70875193a3","type":"text","conversion_output":true,"text":"informed consent according to the procedure described in Section 9.2.","text_display":" informed consent according to the procedure described in Section 9.2.","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1880,2058],[1880,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":1636,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"503811d32f7b45e2974e97ac17ef458c","type":"text","conversion_output":true,"text":"Subjects who agree to take part in the optional PGt analysis will also need to sign a specific PGt","text_display":"\n\nSubjects who agree to take part in the optional PGt analysis will also need to sign a specific PGt","confidence":1,"confidence_rate":1},{"cnt":[[245,2110],[329,2110],[329,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2109,"width":85,"height":42},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"433025625e4548d8afa00a2211affcd9","type":"text","conversion_output":true,"text":"ICF.","text_display":" ICF.","confidence":1,"confidence_rate":1},{"cnt":[[243,2196],[866,2196],[866,2249],[243,2249]],"region":{"top_left_x":242,"top_left_y":2195,"width":624,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcf6d05b2ab44a8c9851c077306faf4f","type":"section_header","conversion_output":false,"children_ids":["fed551598ee24b608fb1d328925735e6"],"text":"","text_display":""},{"cnt":[[245,2200],[862,2200],[862,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2200,"width":618,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fed551598ee24b608fb1d328925735e6","type":"text","conversion_output":true,"parent_id":"fcf6d05b2ab44a8c9851c077306faf4f","text":"Assignment of a Subject Identifier","text_display":"\n\n\\section*{Assignment of a Subject Identifier}","confidence":1,"confidence_rate":1},{"cnt":[[245,2286],[1880,2286],[1880,2335],[245,2335]],"region":{"top_left_x":244,"top_left_y":2285,"width":1636,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1600713070c44c1adbe915042a608a6","type":"text","conversion_output":true,"text":"Once a subject has provided written informed consent for trial participation, a subject","text_display":"\n\nOnce a subject has provided written informed consent for trial participation, a subject","confidence":1,"confidence_rate":1},{"cnt":[[245,2333],[1880,2333],[1880,2383],[245,2383]],"region":{"top_left_x":244,"top_left_y":2333,"width":1636,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b21e2dd5991240cdb33506f0552ccf8b","type":"text","conversion_output":true,"text":"identification number will be assigned through the IVRS. Subjects will be referred to by their","text_display":" identification number will be assigned through the IVRS. Subjects will be referred to by their","confidence":0.9980475902557373,"confidence_rate":0.9999802596071612},{"cnt":[[245,2380],[1085,2380],[1085,2434],[245,2434]],"region":{"top_left_x":244,"top_left_y":2380,"width":841,"height":55},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a34bbce347a4f1bb008d29a4eb9182f","type":"text","conversion_output":true,"text":"subject identification number throughout the trial.","text_display":" subject identification number throughout the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1498d1b9f3c4465d82aa4d1b98fd44e8","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"074e0143bfff4ca899ae858702dc2212","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5f07854b1a84ab0be9d0a8aaf202738","type":"page_info","conversion_output":false,"text":"54/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2608],[1796,2608]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":109},"line":47,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"540d867620394440825fbf40c03f9552","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999186032298787}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-055","page":55,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9878e15940f42e697cfdab8db041087","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03f108f97fbd4844b2184e44bd89aa5b","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6cdcb7f3090b4403b7ddd2e34eead070","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[776,275],[776,337],[241,337]],"region":{"top_left_x":240,"top_left_y":275,"width":536,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d0867953bab4dfc85a06456de040b77","type":"section_header","conversion_output":false,"children_ids":["898d93cecbd74925bfe9193d1c5df6fb"],"text":"","text_display":""},{"cnt":[[245,279],[769,279],[769,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":526,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"898d93cecbd74925bfe9193d1c5df6fb","type":"text","conversion_output":true,"parent_id":"5d0867953bab4dfc85a06456de040b77","text":"Subjects Who Fail Screening","text_display":"\n\n\\section*{Subjects Who Fail Screening}","confidence":0.99951171875,"confidence_rate":0.9999847376009057},{"cnt":[[245,370],[1880,370],[1880,421],[245,421]],"region":{"top_left_x":244,"top_left_y":369,"width":1636,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6a95be9a91540b89f44ed2f68f73ff8","type":"text","conversion_output":true,"text":"The Investigator is required to maintain a subject screening log to identify the subjects who were","text_display":"\n\nThe Investigator is required to maintain a subject screening log to identify the subjects who were","confidence":0.8818933963775635,"confidence_rate":0.9987805102403327},{"cnt":[[245,419],[410,419],[410,466],[245,466]],"region":{"top_left_x":244,"top_left_y":418,"width":167,"height":49},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aae1502dbf4d4bf0974a2b429fa798ed","type":"text","conversion_output":true,"text":"screened.","text_display":" screened.","confidence":1,"confidence_rate":1},{"cnt":[[245,507],[1727,507],[1727,559],[245,559]],"region":{"top_left_x":244,"top_left_y":507,"width":1484,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe783ba2c3c9493e92bba93add5192ea","type":"text","conversion_output":true,"text":"In the CRFs, the minimum information to be recorded for subjects who fail screening is:","text_display":"\n\nIn the CRFs, the minimum information to be recorded for subjects who fail screening is:","confidence":0.998046875,"confidence_rate":0.9999787498471376},{"cnt":[[245,580],[599,580],[599,625],[245,625]],"region":{"top_left_x":244,"top_left_y":580,"width":356,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d3e538e6fe84893b948f912819f1518","type":"text","conversion_output":true,"text":"- Informed consent","text_display":"\n- Informed consent","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[548,649],[548,703],[245,703]],"region":{"top_left_x":244,"top_left_y":648,"width":304,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5150d8c0fe64497aa75398853e451c15","type":"text","conversion_output":true,"text":"- Demographics","text_display":"\n- Demographics","confidence":1,"confidence_rate":1},{"cnt":[[245,724],[376,724],[376,767],[245,767]],"region":{"top_left_x":244,"top_left_y":724,"width":132,"height":43},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b05a4c3d358460486a292fa46565647","type":"text","conversion_output":true,"text":"- AEs","text_display":"\n- AEs","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[922,795],[922,844],[245,844]],"region":{"top_left_x":244,"top_left_y":794,"width":678,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d5c86049a83489aafc6efef6f9b00a0","type":"text","conversion_output":true,"text":"- Date and reason for screening failure","text_display":"\n- Date and reason for screening failure","confidence":1,"confidence_rate":1},{"cnt":[[245,866],[666,866],[666,917],[245,917]],"region":{"top_left_x":244,"top_left_y":865,"width":423,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22163763a368491d8a51b84bc91c3c48","type":"text","conversion_output":true,"text":"- Investigator signature","text_display":"\n- Investigator signature","confidence":1,"confidence_rate":1},{"cnt":[[241,952],[1085,952],[1085,1008],[241,1008]],"region":{"top_left_x":240,"top_left_y":951,"width":845,"height":57},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"093330d864944aa48e3e5defe9e1a3db","type":"section_header","conversion_output":false,"children_ids":["81c68fbeb9ee4158b489e0234c375b19"],"text":"","text_display":""},{"cnt":[[245,958],[1079,958],[1079,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":958,"width":835,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81c68fbeb9ee4158b489e0234c375b19","type":"text","conversion_output":true,"parent_id":"093330d864944aa48e3e5defe9e1a3db","text":"Adverse Events and Concomitant Medications","text_display":"\n\n\\section*{Adverse Events and Concomitant Medications}","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1882,1044],[1882,1096],[245,1096]],"region":{"top_left_x":244,"top_left_y":1044,"width":1639,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1623331f6e3476483cde604535a2140","type":"text","conversion_output":true,"text":"Information about AEs and about concomitant medications and procedures will be collected","text_display":"\n\nInformation about AEs and about concomitant medications and procedures will be collected","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[1820,1091],[1820,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1091,"width":1576,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"919580d0903b49ca9eccd8ea57214b07","type":"text","conversion_output":true,"text":"throughout the trial, beginning at the time of signature of the ICF (see Sections 7.4.1 and 6.5).","text_display":" throughout the trial, beginning at the time of signature of the ICF (see Sections 7.4.1 and 6.5).","confidence":0.99267578125,"confidence_rate":0.9999279322780712},{"cnt":[[241,1182],[1253,1182],[1253,1233],[241,1233]],"region":{"top_left_x":240,"top_left_y":1181,"width":1013,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90be74daad054f5d809e603fb34c7b7e","type":"section_header","conversion_output":false,"children_ids":["6d87de3f60664105ae6841a8f181ac58"],"text":"","text_display":""},{"cnt":[[245,1186],[1246,1186],[1246,1231],[245,1231]],"region":{"top_left_x":244,"top_left_y":1185,"width":1003,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d87de3f60664105ae6841a8f181ac58","type":"text","conversion_output":true,"parent_id":"90be74daad054f5d809e603fb34c7b7e","text":"Allowable Time Frame for Trial Visits and Assessments","text_display":"\n\n\\section*{Allowable Time Frame for Trial Visits and Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[245,1250],[1880,1250],[1880,1302],[245,1302]],"region":{"top_left_x":244,"top_left_y":1250,"width":1636,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2503948352b04ca4b720083596eb8d01","type":"text","conversion_output":true,"text":"Study visits, beginning with Visit 3, should be planned for the study day specified in the","text_display":"\n\nStudy visits, beginning with Visit 3, should be planned for the study day specified in the","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1298],[1880,1298],[1880,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1297,"width":1636,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76082206fecc4bc9bb46371024232cfa","type":"text","conversion_output":true,"text":"protocol. Visits should always be scheduled from the date of the first injection (Week 0/Visit 2)","text_display":" protocol. Visits should always be scheduled from the date of the first injection (Week 0/Visit 2)","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,1349],[1880,1349],[1880,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1349,"width":1636,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"074a0b87dfe94d9c968008a052c3230a","type":"text","conversion_output":true,"text":"while maintaining the minimum and maximum restrictions between injections and between","text_display":" while maintaining the minimum and maximum restrictions between injections and between","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1880,1396],[1880,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1636,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df41795c3f83499f90a0b1299791d3be","type":"text","conversion_output":true,"text":"injection cycles. If a visit cannot be completed within the study days specified in this section the","text_display":" injection cycles. If a visit cannot be completed within the study days specified in this section the","confidence":1,"confidence_rate":1},{"cnt":[[245,1444],[735,1444],[735,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1443,"width":491,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5205eb93f63d4f16b6f11cd79071e8f6","type":"text","conversion_output":true,"text":"sponsor should be contacted.","text_display":" sponsor should be contacted.","confidence":1,"confidence_rate":1},{"cnt":[[241,1530],[1179,1530],[1179,1590],[241,1590]],"region":{"top_left_x":240,"top_left_y":1529,"width":940,"height":61},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb099c99f9d64fa1b40accd6cb8ab4a9","type":"section_header","conversion_output":false,"children_ids":["4ba851ffec974cdbb9ff74385490e40a"],"text":"","text_display":""},{"cnt":[[245,1534],[1175,1534],[1175,1588],[245,1588]],"region":{"top_left_x":244,"top_left_y":1533,"width":932,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ba851ffec974cdbb9ff74385490e40a","type":"text","conversion_output":true,"parent_id":"cb099c99f9d64fa1b40accd6cb8ab4a9","text":"Allowable intervals between weekly IMP injections:","text_display":"\n\n\\section*{Allowable intervals between weekly IMP injections:}","confidence":1,"confidence_rate":1},{"cnt":[[245,1603],[1880,1603],[1880,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":1602,"width":1636,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05701c40e3f54cc898a97af65a5e87d1","type":"text","conversion_output":true,"text":"The interval between each injection within a treatment cycle should be 7 days. If it is not","text_display":"\n\nThe interval between each injection within a treatment cycle should be 7 days. If it is not","confidence":1,"confidence_rate":1},{"cnt":[[245,1650],[1880,1650],[1880,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1649,"width":1636,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac5e80cc1cb240da805110a59c32995a","type":"text","conversion_output":true,"text":"possible to complete the visit in exactly 7 days, or if an emergency occurs, the interval to the","text_display":" possible to complete the visit in exactly 7 days, or if an emergency occurs, the interval to the","confidence":1,"confidence_rate":1},{"cnt":[[245,1697],[1880,1697],[1880,1749],[245,1749]],"region":{"top_left_x":244,"top_left_y":1697,"width":1636,"height":52},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9883714dd092464eb4402bc4e6951ea4","type":"text","conversion_output":true,"text":"next injection should be no shorter than 6 days and no longer than 9 days (i.e., \\(-1 /+2\\) days). This","text_display":" next injection should be no shorter than 6 days and no longer than 9 days (i.e., \\(-1 /+2\\) days). This","confidence":0.9917097059078515,"confidence_rate":0.9999256737471826},{"cnt":[[245,1745],[1326,1745],[1326,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1744,"width":1082,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47bec3f7878d4b2e97faf62132372a23","type":"text","conversion_output":true,"text":"interval allowance applies to Visits \\(3,4,8,9,13,14,18\\), and 19 .","text_display":" interval allowance applies to Visits \\(3,4,8,9,13,14,18\\), and 19 .","confidence":0.9917066079797223,"confidence_rate":0.9998889665176431},{"cnt":[[241,1830],[1257,1830],[1257,1893],[241,1893]],"region":{"top_left_x":240,"top_left_y":1830,"width":1017,"height":63},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0027ca7acf4a41458cb603fc865790cb","type":"section_header","conversion_output":false,"children_ids":["67be82d5f558419d8b0d14cbccd9f2b8"],"text":"","text_display":""},{"cnt":[[245,1835],[1253,1835],[1253,1888],[245,1888]],"region":{"top_left_x":244,"top_left_y":1834,"width":1009,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67be82d5f558419d8b0d14cbccd9f2b8","type":"text","conversion_output":true,"parent_id":"0027ca7acf4a41458cb603fc865790cb","text":"Allowable intervals between six month treatment cycles:","text_display":"\n\n\\section*{Allowable intervals between six month treatment cycles:}","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1880,1925],[1880,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1925,"width":1636,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4623fd7e9ac64049bd3f0da1d922ea0c","type":"text","conversion_output":true,"text":"The interval between the last injection of a treatment cycle and the first injection of the","text_display":"\n\nThe interval between the last injection of a treatment cycle and the first injection of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1972],[1880,1972],[1880,2024],[245,2024]],"region":{"top_left_x":244,"top_left_y":1972,"width":1636,"height":52},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a25ba09b0eb4e80a245fd863ae881ca","type":"text","conversion_output":true,"text":"subsequent treatment cycle is 24 weeks. If a visit cannot be done as planned, or if an emergency","text_display":" subsequent treatment cycle is 24 weeks. If a visit cannot be done as planned, or if an emergency","confidence":1,"confidence_rate":1},{"cnt":[[245,2020],[1880,2020],[1880,2073],[245,2073]],"region":{"top_left_x":244,"top_left_y":2019,"width":1636,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfae4eff8cd745fb93aebb66f7d3532a","type":"text","conversion_output":true,"text":"occurs, it can be rescheduled \\(\\pm 3\\) weeks from the planned day (i.e., between 21 and 27 weeks).","text_display":" occurs, it can be rescheduled \\(\\pm 3\\) weeks from the planned day (i.e., between 21 and 27 weeks).","confidence":0.9185359285911545,"confidence_rate":0.9991986772825677},{"cnt":[[245,2067],[466,2067],[466,2121],[245,2121]],"region":{"top_left_x":244,"top_left_y":2066,"width":223,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f62217ba03cd4c7f83ed2f1d14baa0b7","type":"text","conversion_output":true,"text":"Specifically:","text_display":" Specifically:","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1592,2140],[1592,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2139,"width":1348,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e283ffeaabc4b969074119e94068c77","type":"text","conversion_output":true,"text":"- Visit 7 must be conducted within 21 to 27 weeks of the actual date of Visit 4,","text_display":"\n- Visit 7 must be conducted within 21 to 27 weeks of the actual date of Visit 4,","confidence":0.78173828125,"confidence_rate":0.9973839037770289},{"cnt":[[245,2211],[1687,2211],[1687,2262],[245,2262]],"region":{"top_left_x":244,"top_left_y":2210,"width":1443,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b942ded7eba94f1c8e315faa6e3a08fa","type":"text","conversion_output":true,"text":"- Visit 12 must be conducted within 21 to 27 weeks of the actual date of Visit 9 , and","text_display":"\n- Visit 12 must be conducted within 21 to 27 weeks of the actual date of Visit 9 , and","confidence":0.6787109375,"confidence_rate":0.9962443520945611},{"cnt":[[245,2282],[1624,2282],[1624,2331],[245,2331]],"region":{"top_left_x":244,"top_left_y":2281,"width":1381,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89e3855133c84f74a01282bff25884c2","type":"text","conversion_output":true,"text":"- Visit 17 must be conducted within 21 to 27 weeks of the actual date of Visit 14","text_display":"\n- Visit 17 must be conducted within 21 to 27 weeks of the actual date of Visit 14","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b207737f249a4201a8a3721e8b12d78b","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61b2b2d9789d4114a65b9935011d0ab7","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2529],[1601,2529],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2528,"width":93,"height":36},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a66da50c6f9e46b2a811869dfe6549bc","type":"page_info","conversion_output":false,"text":"55/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-056","page":56,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28d681e81f884b6e8fc36b6b5765ebf0","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a64a6531366438d85e4e0f0c7a67e9e","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d5060c2c16147b6bedd23c6014f3589","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,277],[887,277],[887,331],[241,331]],"region":{"top_left_x":240,"top_left_y":277,"width":648,"height":54},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cdad945eed443c19cb642e1767d5678","type":"section_header","conversion_output":false,"children_ids":["3daf2e6ece7f466ea537b71e22df2671"],"text":"","text_display":""},{"cnt":[[245,284],[881,284],[881,324],[245,324]],"region":{"top_left_x":244,"top_left_y":283,"width":637,"height":42},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3daf2e6ece7f466ea537b71e22df2671","type":"text","conversion_output":true,"parent_id":"8cdad945eed443c19cb642e1767d5678","text":"Allowable intervals for other visits:","text_display":"\n\n\\section*{Allowable intervals for other visits:}","confidence":1,"confidence_rate":1},{"cnt":[[245,348],[1880,348],[1880,400],[245,400]],"region":{"top_left_x":244,"top_left_y":348,"width":1636,"height":52},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5e3cb8f46644e1aad5c2c68b2c4c522","type":"text","conversion_output":true,"text":"During the DBPC treatment phase, visits may take place within \\(\\pm 4\\) days of the planned day. This","text_display":"\n\nDuring the DBPC treatment phase, visits may take place within \\(\\pm 4\\) days of the planned day. This","confidence":0.96240234375,"confidence_rate":0.9996243580318365},{"cnt":[[245,397],[1369,397],[1369,449],[245,449]],"region":{"top_left_x":244,"top_left_y":397,"width":1125,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab4e15e34b9c4f119bb78982778a0998","type":"text","conversion_output":true,"text":"interval allowance applies to Visits \\(5,6,10,11,15,16,20\\), and 21.","text_display":" interval allowance applies to Visits \\(5,6,10,11,15,16,20\\), and 21.","confidence":0.9210202212016156,"confidence_rate":0.9988579680700256},{"cnt":[[245,466],[1880,466],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1636,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e51e18756fb34579bc3a555e711ddf38","type":"text","conversion_output":true,"text":"Extended follow-up visits may take place within \\(\\pm 21\\) days of the planned day. This interval","text_display":"\nExtended follow-up visits may take place within \\(\\pm 21\\) days of the planned day. This interval","confidence":0.99853515625,"confidence_rate":0.9999850417681765},{"cnt":[[245,516],[1296,516],[1296,569],[245,569]],"region":{"top_left_x":244,"top_left_y":515,"width":1052,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96c1168c9a5441dfb79dbdb8df5225cd","type":"text","conversion_output":true,"text":"allowance applies from Visit 22 (EF1) through Visit 28 (EF6).","text_display":" allowance applies from Visit 22 (EF1) through Visit 28 (EF6).","confidence":1,"confidence_rate":1},{"cnt":[[241,597],[1001,597],[1001,662],[241,662]],"region":{"top_left_x":240,"top_left_y":597,"width":762,"height":65},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91d0dec80ffa43759618da1bdd11ae80","type":"section_header","conversion_output":false,"children_ids":["8b45d33770ca4c74826de7c90a466133"],"text":"","text_display":""},{"cnt":[[245,604],[995,604],[995,655],[245,655]],"region":{"top_left_x":244,"top_left_y":603,"width":751,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b45d33770ca4c74826de7c90a466133","type":"text","conversion_output":true,"parent_id":"91d0dec80ffa43759618da1bdd11ae80","text":"Allowable intervals for X-rays and MRIs:","text_display":"\n\n\\section*{Allowable intervals for X-rays and MRIs:}","confidence":1,"confidence_rate":1},{"cnt":[[245,670],[1880,670],[1880,724],[245,724]],"region":{"top_left_x":244,"top_left_y":670,"width":1636,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd7d83183216442989433ae6915a1a05","type":"text","conversion_output":true,"text":"At time points where IMP administration is scheduled, X-rays and MRIs may be performed up to","text_display":"\n\nAt time points where IMP administration is scheduled, X-rays and MRIs may be performed up to","confidence":1,"confidence_rate":1},{"cnt":[[245,722],[885,722],[885,771],[245,771]],"region":{"top_left_x":244,"top_left_y":721,"width":642,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c4d3a0ec76943d69fae5c793f3a3636","type":"text","conversion_output":true,"text":"3 days before the IMP administration.","text_display":" 3 days before the IMP administration.","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[1882,786],[1882,840],[245,840]],"region":{"top_left_x":244,"top_left_y":786,"width":1639,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c829b81c24b4fe895f0f362dc18266c","type":"text","conversion_output":true,"text":"During the DBPC phase, at time points where there is no IMP administration scheduled, X-rays","text_display":"\nDuring the DBPC phase, at time points where there is no IMP administration scheduled, X-rays","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,838],[1326,838],[1326,887],[245,887]],"region":{"top_left_x":244,"top_left_y":837,"width":1082,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a6237acf86040aeb6e56c322194982a","type":"text","conversion_output":true,"text":"and MRIs may be performed within \\(\\pm 4\\) days of the planned day.","text_display":" and MRIs may be performed within \\(\\pm 4\\) days of the planned day.","confidence":0.9985356330871582,"confidence_rate":0.9999784496418309},{"cnt":[[245,904],[1882,904],[1882,956],[245,956]],"region":{"top_left_x":244,"top_left_y":904,"width":1639,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4cb72c2196bc4bff9970f1e1f548bad1","type":"text","conversion_output":true,"text":"During the extended follow up phase, at time points when there is no IMP administration","text_display":"\nDuring the extended follow up phase, at time points when there is no IMP administration","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,954],[1644,954],[1644,1005],[245,1005]],"region":{"top_left_x":244,"top_left_y":953,"width":1400,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"064df9ec521046179b773d3791017a87","type":"text","conversion_output":true,"text":"scheduled, X-rays and MRIs may be performed within \\(\\pm 7\\) days of the planned day.","text_display":" scheduled, X-rays and MRIs may be performed within \\(\\pm 7\\) days of the planned day.","confidence":0.8633766174316406,"confidence_rate":0.9982932688436361},{"cnt":[[241,1040],[726,1040],[726,1096],[241,1096]],"region":{"top_left_x":240,"top_left_y":1039,"width":487,"height":57},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19824fc2c5f142909c2bab05c30b1fef","type":"section_header","conversion_output":false,"children_ids":["fae1cfbad2f74a46a6d0ba4dcd4ff5b6"],"text":"","text_display":""},{"cnt":[[245,1044],[720,1044],[720,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1044,"width":476,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fae1cfbad2f74a46a6d0ba4dcd4ff5b6","type":"text","conversion_output":true,"parent_id":"19824fc2c5f142909c2bab05c30b1fef","text":"Pain Medication Washout","text_display":"\n\n\\section*{Pain Medication Washout}","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1882,1130],[1882,1184],[245,1184]],"region":{"top_left_x":244,"top_left_y":1130,"width":1639,"height":54},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c874b02411a044f5b34ff90a032d08c1","type":"text","conversion_output":true,"text":"Subjects will be requested to discontinue the intake of all pain medications for 5 half-lives before","text_display":"\n\nSubjects will be requested to discontinue the intake of all pain medications for 5 half-lives before","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,1179],[1882,1179],[1882,1231],[245,1231]],"region":{"top_left_x":244,"top_left_y":1179,"width":1639,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb59f0b3f7824b0aac7e44c6352094f9","type":"text","conversion_output":true,"text":"a visit involving completion of the WOMAC. At least 3 days before each such visit, subjects will","text_display":" a visit involving completion of the WOMAC. At least 3 days before each such visit, subjects will","confidence":0.9921910762786865,"confidence_rate":0.9999246223311434},{"cnt":[[245,1229],[1231,1229],[1231,1280],[245,1280]],"region":{"top_left_x":244,"top_left_y":1228,"width":988,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c845d31d9d7444c2b04e02c501039dc7","type":"text","conversion_output":true,"text":"be contacted by phone to remind them of this requirement.","text_display":" be contacted by phone to remind them of this requirement.","confidence":1,"confidence_rate":1},{"cnt":[[245,1319],[1882,1319],[1882,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1319,"width":1639,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6cb48bff054a4e058f8f92b1fe078414","type":"text","conversion_output":true,"text":"Aspirin (acetylsalicylic acid) used for cardiovascular protection does not need to be withheld, nor","text_display":"\n\nAspirin (acetylsalicylic acid) used for cardiovascular protection does not need to be withheld, nor","confidence":1,"confidence_rate":1},{"cnt":[[245,1366],[1373,1366],[1373,1420],[245,1420]],"region":{"top_left_x":244,"top_left_y":1366,"width":1129,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"def8cfb54004498faa294faeea0c7562","type":"text","conversion_output":true,"text":"do antidepressants used for management of OA pain or depression.","text_display":" do antidepressants used for management of OA pain or depression.","confidence":0.9677734375,"confidence_rate":0.9995253696107802},{"cnt":[[236,1450],[677,1450],[677,1515],[236,1515]],"region":{"top_left_x":236,"top_left_y":1450,"width":441,"height":65},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80cb1dfd3fcc4647b4dc791dd9b8b5c5","type":"section_header","conversion_output":false,"children_ids":["df625e974e3f45cabc439c0697733fb1"],"text":"","text_display":""},{"cnt":[[245,1457],[672,1457],[672,1508],[245,1508]],"region":{"top_left_x":244,"top_left_y":1456,"width":429,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df625e974e3f45cabc439c0697733fb1","type":"text","conversion_output":true,"parent_id":"80cb1dfd3fcc4647b4dc791dd9b8b5c5","text":"Subject Questionnaires","text_display":"\n\n\\section*{Subject Questionnaires}","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1880,1543],[1880,1596],[245,1596]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b4cc35cd559483292963dac71df2b45","type":"text","conversion_output":true,"text":"At visits involving completion of subject questionnaires (WOMAC, PGA, KOOS QOL, KOOS","text_display":"\n\nAt visits involving completion of subject questionnaires (WOMAC, PGA, KOOS QOL, KOOS","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1882,1594],[1882,1646],[245,1646]],"region":{"top_left_x":244,"top_left_y":1594,"width":1639,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3df146630d0486b95a7ef7f1833035e","type":"text","conversion_output":true,"text":"Symptom Index, PGIC, NRS pain score in the target and contralateral knee, MOS SF-36, pain in","text_display":" Symptom Index, PGIC, NRS pain score in the target and contralateral knee, MOS SF-36, pain in","confidence":1,"confidence_rate":1},{"cnt":[[245,1641],[1882,1641],[1882,1693],[245,1693]],"region":{"top_left_x":244,"top_left_y":1641,"width":1639,"height":52},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e22e01df6b9d4493ae85e8e9c9cab3a9","type":"text","conversion_output":true,"text":"other joints, and ICOAP), these questionnaires must be completed before any other trial","text_display":" other joints, and ICOAP), these questionnaires must be completed before any other trial","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1386,1689],[1386,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1688,"width":1142,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3223c00ec3a240029253266d78b21095","type":"text","conversion_output":true,"text":"procedures are performed. The WOMAC should be completed first.","text_display":" procedures are performed. The WOMAC should be completed first.","confidence":1,"confidence_rate":1},{"cnt":[[236,1772],[535,1772],[535,1837],[236,1837]],"region":{"top_left_x":236,"top_left_y":1772,"width":299,"height":65},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a9ba4022d944bbfa1aef5f04c8f1218","type":"section_header","conversion_output":false,"children_ids":["6216f73915d2462285623a28f65f6e3e"],"text":"","text_display":""},{"cnt":[[245,1779],[526,1779],[526,1830],[245,1830]],"region":{"top_left_x":244,"top_left_y":1778,"width":283,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6216f73915d2462285623a28f65f6e3e","type":"text","conversion_output":true,"parent_id":"9a9ba4022d944bbfa1aef5f04c8f1218","text":"Subject Diaries","text_display":"\n\n\\section*{Subject Diaries}","confidence":1,"confidence_rate":1},{"cnt":[[245,1867],[1661,1867],[1661,1921],[245,1921]],"region":{"top_left_x":244,"top_left_y":1866,"width":1417,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60a4445508e94e1b97e59b4d5bf03a8d","type":"text","conversion_output":true,"text":"Subjects will receive diaries at each visit for recording of the following information:","text_display":"\n\nSubjects will receive diaries at each visit for recording of the following information:","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,1938],[1880,1938],[1880,1992],[245,1992]],"region":{"top_left_x":244,"top_left_y":1937,"width":1636,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a3a5df04e864832b5f4bed441526dd2","type":"text","conversion_output":true,"text":"- Any adverse reaction occurring between trial visits and any concomitant medications used,","text_display":"\n- Any adverse reaction occurring between trial visits and any concomitant medications used,","confidence":1,"confidence_rate":1},{"cnt":[[292,1989],[1747,1989],[1747,2039],[292,2039]],"region":{"top_left_x":292,"top_left_y":1989,"width":1455,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5158ead67ac847c79790962d42bbc583","type":"text","conversion_output":true,"text":"with particular attention to the use of NSAIDs, coxibs, and any other pain medications","text_display":" with particular attention to the use of NSAIDs, coxibs, and any other pain medications","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1882,2058],[1882,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2058,"width":1639,"height":54},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"890c85b8a5b84a8287e276dd88b9e2d3","type":"text","conversion_output":true,"text":"- Maximum pain level (using a \\(100- mm\\) VAS) and presence or absence of joint swelling, to be","text_display":"\n- Maximum pain level (using a \\(100- mm\\) VAS) and presence or absence of joint swelling, to be","confidence":0.99755859375,"confidence_rate":0.9999757983983905},{"cnt":[[294,2108],[1884,2108],[1884,2159],[294,2159]],"region":{"top_left_x":294,"top_left_y":2107,"width":1591,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a7a71b23eec4a11a2e107e58b6494a8","type":"text","conversion_output":true,"text":"recorded once daily on the day before each IMP injection and on each of the 3 days following","text_display":" recorded once daily on the day before each IMP injection and on each of the 3 days following","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[294,2157],[595,2157],[595,2206],[294,2206]],"region":{"top_left_x":294,"top_left_y":2157,"width":302,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"177eb4adf78d4bbebcb3b7505a06d5c8","type":"text","conversion_output":true,"text":"an IMP injection.","text_display":" an IMP injection.","confidence":1,"confidence_rate":1},{"cnt":[[294,2226],[1884,2226],[1884,2279],[294,2279]],"region":{"top_left_x":294,"top_left_y":2225,"width":1591,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3597ecb64fc54240aa6e93887be7b163","type":"text","conversion_output":true,"text":"- Diaries given at the visit before the beginning of a treatment cycle (e.g., screening or","text_display":"\n- Diaries given at the visit before the beginning of a treatment cycle (e.g., screening or","confidence":1,"confidence_rate":1},{"cnt":[[344,2275],[1884,2275],[1884,2327],[344,2327]],"region":{"top_left_x":343,"top_left_y":2275,"width":1542,"height":52},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34e4b1c233a946e5bbca6b90dc5afcfd","type":"text","conversion_output":true,"text":"Week 12/Visit 6) will collect pain and swelling information for the day before the next","text_display":" Week 12/Visit 6) will collect pain and swelling information for the day before the next","confidence":0.9941470623016357,"confidence_rate":0.9999361962391613},{"cnt":[[344,2325],[1884,2325],[1884,2374],[344,2374]],"region":{"top_left_x":343,"top_left_y":2324,"width":1542,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39092c6f0ef5458dbe9365d9e4eca92b","type":"text","conversion_output":true,"text":"visit. Telephone contacts concerning the need to withhold pain medications before the next","text_display":" visit. Telephone contacts concerning the need to withhold pain medications before the next","confidence":1,"confidence_rate":1},{"cnt":[[344,2372],[1416,2372],[1416,2426],[344,2426]],"region":{"top_left_x":343,"top_left_y":2371,"width":1073,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a46de4dcd6ca41d3b9b110d21dd1f39b","type":"text","conversion_output":true,"text":"visit will include a reminder to complete this diary information.","text_display":" visit will include a reminder to complete this diary information.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"889101a088e541dcbcd8ae0580d301c3","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[391,2548],[391,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":148,"height":41},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4916b3ff8f2248edbddc0ed514d26f07","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44c61ca6205f4574ac898d03a6f585cf","type":"page_info","conversion_output":false,"text":"56/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-057","page":57,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44e4e1bade5a4459b18c2ad42be21ee1","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c3b368d4dc94663bc82bd57c1827e7c","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5967e23c06564580b6a18402b34a4c83","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[294,281],[1882,281],[1882,333],[294,333]],"region":{"top_left_x":294,"top_left_y":281,"width":1589,"height":53},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4d655a9c0d04789878f3358d60e8da5","type":"text","conversion_output":true,"text":"- Diaries given at visits where the first and second doses of a cycle are administered will","text_display":"\n- Diaries given at visits where the first and second doses of a cycle are administered will","confidence":1,"confidence_rate":1},{"cnt":[[344,331],[1880,331],[1880,382],[344,382]],"region":{"top_left_x":343,"top_left_y":330,"width":1537,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed46ac9c0d704299a6d1e6885d74beaa","type":"text","conversion_output":true,"text":"collect pain and swelling information for the 3 days after the injection and for the day","text_display":" collect pain and swelling information for the 3 days after the injection and for the day","confidence":1,"confidence_rate":1},{"cnt":[[343,425],[344,378],[698,380],[698,427]],"region":{"top_left_x":343,"top_left_y":378,"width":356,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1dfc2a72f5004c53a9a1ac46383fa836","type":"text","conversion_output":true,"text":"before the next visit.","text_display":" before the next visit.","confidence":1,"confidence_rate":1},{"cnt":[[294,451],[1882,451],[1882,501],[294,501]],"region":{"top_left_x":294,"top_left_y":451,"width":1589,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ec737972aaf42b7988715a6c098ec1d","type":"text","conversion_output":true,"text":"- Diaries given at visits where the last dose of a cycle is administered will collect pain and","text_display":"\n- Diaries given at visits where the last dose of a cycle is administered will collect pain and","confidence":1,"confidence_rate":1},{"cnt":[[344,498],[1257,498],[1257,552],[344,552]],"region":{"top_left_x":343,"top_left_y":498,"width":914,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5597cf34a2204401b303029e32ad4d4a","type":"text","conversion_output":true,"text":"swelling information for the 3 days after the injection.","text_display":" swelling information for the 3 days after the injection.","confidence":0.99951171875,"confidence_rate":0.999992368771335},{"cnt":[[294,571],[1880,571],[1880,621],[294,621]],"region":{"top_left_x":294,"top_left_y":571,"width":1586,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e79376e7f7dd485bb17028f522d15ed2","type":"text","conversion_output":true,"text":"- Diaries given at all other visits will collect adverse reactions and concomitant medications","text_display":"\n- Diaries given at all other visits will collect adverse reactions and concomitant medications","confidence":1,"confidence_rate":1},{"cnt":[[344,619],[436,619],[436,668],[344,668]],"region":{"top_left_x":343,"top_left_y":618,"width":94,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"851c948a0caf4a258bb788f48a90ddc7","type":"text","conversion_output":true,"text":"only.","text_display":" only.","confidence":1,"confidence_rate":1},{"cnt":[[245,709],[1880,709],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1636,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a8f27c98949476998a1809eb34a82c9","type":"text","conversion_output":true,"text":"Different diaries will be dispensed, depending on the data to be completed prior to the next visit.","text_display":"\n\nDifferent diaries will be dispensed, depending on the data to be completed prior to the next visit.","confidence":1,"confidence_rate":1},{"cnt":[[245,756],[1880,756],[1880,806],[245,806]],"region":{"top_left_x":244,"top_left_y":756,"width":1636,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de38df3d66ea4a56ac6d8b7453612a10","type":"text","conversion_output":true,"text":"Completed diaries will be collected and reviewed at each visit, and information will be","text_display":" Completed diaries will be collected and reviewed at each visit, and information will be","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,804],[1880,804],[1880,855],[245,855]],"region":{"top_left_x":244,"top_left_y":803,"width":1636,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00b9ddd73ba2492799474bd50de46a69","type":"text","conversion_output":true,"text":"transcribed to the CRFs (following medical review in case of AE or concomitant medication","text_display":" transcribed to the CRFs (following medical review in case of AE or concomitant medication","confidence":1,"confidence_rate":1},{"cnt":[[245,851],[475,851],[475,904],[245,904]],"region":{"top_left_x":244,"top_left_y":850,"width":231,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bceea43cd1a2471ca81b42fb16d32255","type":"text","conversion_output":true,"text":"information).","text_display":" information).","confidence":1,"confidence_rate":1},{"cnt":[[241,937],[728,937],[728,999],[241,999]],"region":{"top_left_x":240,"top_left_y":936,"width":489,"height":64},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d454fe3482ed4905ab75aef8a22a1020","type":"section_header","conversion_output":false,"children_ids":["5e97bbe0045c4cd49b68032b5e2cd0e8"],"text":"","text_display":""},{"cnt":[[245,941],[724,941],[724,995],[245,995]],"region":{"top_left_x":244,"top_left_y":941,"width":481,"height":54},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e97bbe0045c4cd49b68032b5e2cd0e8","type":"text","conversion_output":true,"parent_id":"d454fe3482ed4905ab75aef8a22a1020","text":"Pharmacogenetic Analysis","text_display":"\n\n\\section*{Pharmacogenetic Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[245,1031],[1880,1031],[1880,1081],[245,1081]],"region":{"top_left_x":244,"top_left_y":1031,"width":1636,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2d9fdbdcc41442b9a0b56a067f73520","type":"text","conversion_output":true,"text":"All subjects who are enrolled in the trial will be eligible to participate in an optional PGt analysis","text_display":"\n\nAll subjects who are enrolled in the trial will be eligible to participate in an optional PGt analysis","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1880,1079],[1880,1130],[245,1130]],"region":{"top_left_x":244,"top_left_y":1078,"width":1636,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"057661fcc792460782a61688cbc33a0f","type":"text","conversion_output":true,"text":"(except in countries where collection of PGt samples is not allowed; the analysis is described in","text_display":" (except in countries where collection of PGt samples is not allowed; the analysis is described in","confidence":0.994631290435791,"confidence_rate":0.9999472251879841},{"cnt":[[245,1126],[1880,1126],[1880,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1125,"width":1636,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"741a28bac41646899fdbc147e8680026","type":"text","conversion_output":true,"text":"Section 7.6.3). Participation is optional, and the subjects who choose to participate will need to","text_display":" Section 7.6.3). Participation is optional, and the subjects who choose to participate will need to","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[941,1177],[941,1227],[245,1227]],"region":{"top_left_x":244,"top_left_y":1177,"width":698,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9219479adbc24c808223ca0d59e297a5","type":"text","conversion_output":true,"text":"sign a specific PGt ICF (see Section 9.2).","text_display":" sign a specific PGt ICF (see Section 9.2).","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1880,1263],[1880,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1263,"width":1636,"height":54},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bdc4a6684c04b1c983edce128f63956","type":"text","conversion_output":true,"text":"For consenting subjects, a single blood sample will be collected for PGt analysis. This sample","text_display":"\n\nFor consenting subjects, a single blood sample will be collected for PGt analysis. This sample","confidence":1,"confidence_rate":1},{"cnt":[[245,1315],[1175,1315],[1175,1364],[245,1364]],"region":{"top_left_x":244,"top_left_y":1314,"width":932,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d67cda9031347f7bf7d77540c34fe33","type":"text","conversion_output":true,"text":"can be obtained at any trial visit, preferably at baseline.","text_display":" can be obtained at any trial visit, preferably at baseline.","confidence":1,"confidence_rate":1},{"cnt":[[241,1396],[1343,1396],[1343,1470],[241,1470]],"region":{"top_left_x":240,"top_left_y":1396,"width":1103,"height":74},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed20bd6de31d46709efb7ce7d53e9181","type":"section_header","conversion_output":false,"children_ids":["c3dad9234dc74ebca8f3c8611d29ffe8"],"text":"","text_display":""},{"cnt":[[245,1403],[1336,1403],[1336,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1402,"width":1093,"height":62},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3dad9234dc74ebca8f3c8611d29ffe8","type":"text","conversion_output":true,"parent_id":"ed20bd6de31d46709efb7ce7d53e9181","text":"7.1.2 Screening Period (Visits 1a and 1b)","text_display":"\n\n\\subsection*{7.1.2 Screening Period (Visits 1a and 1b)}","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1882,1500],[1882,1551],[245,1551]],"region":{"top_left_x":244,"top_left_y":1499,"width":1639,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5c4528b32c7448aa6698dcf7d2d2c59","type":"text","conversion_output":true,"text":"The screening period will comprise a period of 4 to 42 days before the baseline visit, beginning","text_display":"\n\nThe screening period will comprise a period of 4 to 42 days before the baseline visit, beginning","confidence":1,"confidence_rate":1},{"cnt":[[245,1547],[1762,1547],[1762,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1546,"width":1518,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cf719b93eff4a3cbe8e42c172cf6ead","type":"text","conversion_output":true,"text":"at signature of the ICF, during which a subject's eligibility for the trial will be determined.","text_display":" at signature of the ICF, during which a subject's eligibility for the trial will be determined.","confidence":1,"confidence_rate":1},{"cnt":[[245,1637],[1815,1637],[1815,1689],[245,1689]],"region":{"top_left_x":244,"top_left_y":1637,"width":1572,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44bb693562f94a05bfbb575b31bbe83e","type":"text","conversion_output":true,"text":"Eligibility will be confirmed at the baseline visit (Week 0/Visit 2) as described in Section 5.4.","text_display":"\n\nEligibility will be confirmed at the baseline visit (Week 0/Visit 2) as described in Section 5.4.","confidence":0.9965846532722935,"confidence_rate":0.9999664594611436},{"cnt":[[245,1727],[1880,1727],[1880,1777],[245,1777]],"region":{"top_left_x":244,"top_left_y":1727,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"130c5c1fbabe470ebf486c9564435bac","type":"text","conversion_output":true,"text":"Prior to performing any trial assessments not part of the subject's routine medical care, the","text_display":"\nPrior to performing any trial assessments not part of the subject's routine medical care, the","confidence":1,"confidence_rate":1},{"cnt":[[245,1775],[1880,1775],[1880,1824],[245,1824]],"region":{"top_left_x":244,"top_left_y":1774,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5b067acfc094848b9e6d3313a86ecaf","type":"text","conversion_output":true,"text":"Investigator will ensure that the subject or the subject's legal representative has provided written","text_display":" Investigator will ensure that the subject or the subject's legal representative has provided written","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,1822],[1420,1822],[1420,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1821,"width":1177,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3408b66a2e1a41a88f19c32ca3e8dd2a","type":"text","conversion_output":true,"text":"informed consent according to the procedure described in Section 9.2.","text_display":" informed consent according to the procedure described in Section 9.2.","confidence":1,"confidence_rate":1},{"cnt":[[236,1908],[400,1908],[400,1970],[236,1970]],"region":{"top_left_x":236,"top_left_y":1907,"width":164,"height":64},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3ad51a1949f427aba6c268d1443b621","type":"section_header","conversion_output":false,"children_ids":["2d8a077fcf9e4956ad0ccc9adb07544c"],"text":"","text_display":""},{"cnt":[[245,1916],[393,1916],[393,1964],[245,1964]],"region":{"top_left_x":244,"top_left_y":1916,"width":150,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d8a077fcf9e4956ad0ccc9adb07544c","type":"text","conversion_output":true,"parent_id":"d3ad51a1949f427aba6c268d1443b621","text":"Visit 1a","text_display":"\n\n\\section*{Visit 1a}","confidence":1,"confidence_rate":1},{"cnt":[[245,2002],[1674,2002],[1674,2054],[245,2054]],"region":{"top_left_x":244,"top_left_y":2002,"width":1430,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b07c23d7fc8c48ef9f3037f722ac19c9","type":"text","conversion_output":true,"text":"The following procedures will be performed during the subject's first screening visit.","text_display":"\n\nThe following procedures will be performed during the subject's first screening visit.","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[245,2073],[733,2073],[733,2121],[245,2121]],"region":{"top_left_x":244,"top_left_y":2073,"width":489,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d9f1c293f314612be701434d8db6587","type":"text","conversion_output":true,"text":"- Informed consent for trial","text_display":"\n- Informed consent for trial","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1023,2144],[1023,2198],[245,2198]],"region":{"top_left_x":244,"top_left_y":2144,"width":779,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9da06799862045c6ba56da7ecaf662db","type":"text","conversion_output":true,"text":"- Informed consent for optional PGt analysis","text_display":"\n- Informed consent for optional PGt analysis","confidence":1,"confidence_rate":1},{"cnt":[[245,2217],[1880,2217],[1880,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2217,"width":1636,"height":54},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf0d6f0d7ba24d1d9a4d80d780b66c76","type":"text","conversion_output":true,"text":"- WOMAC (Question 1 of the WOMAC pain index only; see Section 5.4 and Appendix C): this","text_display":"\n- WOMAC (Question 1 of the WOMAC pain index only; see Section 5.4 and Appendix C): this","confidence":1,"confidence_rate":1},{"cnt":[[294,2264],[1880,2264],[1880,2316],[294,2316]],"region":{"top_left_x":294,"top_left_y":2264,"width":1586,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cefebe46d51c4d8eae2ea4002ca3c97b","type":"text","conversion_output":true,"text":"assessment should be done after informed consent is obtained and before any other procedures","text_display":" assessment should be done after informed consent is obtained and before any other procedures","confidence":1,"confidence_rate":1},{"cnt":[[294,2312],[1882,2312],[1882,2363],[294,2363]],"region":{"top_left_x":294,"top_left_y":2311,"width":1589,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86c071ad752a4ec4a51244d09c58fcd7","type":"text","conversion_output":true,"text":"or examinations are performed. The question should be answered for both knees, since the","text_display":" or examinations are performed. The question should be answered for both knees, since the","confidence":1,"confidence_rate":1},{"cnt":[[294,2359],[947,2359],[947,2413],[294,2413]],"region":{"top_left_x":294,"top_left_y":2358,"width":654,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34ff4a13980e4ae99db77edc08188b1a","type":"text","conversion_output":true,"text":"target knee has not yet been identified.","text_display":" target knee has not yet been identified.","confidence":1,"confidence_rate":1},{"cnt":[[245,2432],[707,2432],[707,2484],[245,2484]],"region":{"top_left_x":244,"top_left_y":2432,"width":463,"height":52},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37e60a8d4a9d4d948879df0cb5954a5e","type":"text","conversion_output":true,"text":"- PGA (see Section 7.3.3)","text_display":"\n- PGA (see Section 7.3.3)","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fbdfbf26ef1a4c25a10e693f2daa48ec","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0b59083a25ef4dea81262792b7ca7403","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90c7a2f783bc4c379ac725b162679d38","type":"page_info","conversion_output":false,"text":"57/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-058","page":58,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae79cfb13b0b40b1841334407e781150","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3eae4d2ff3444ab09251241fdad55502","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b8cc114057047f3b94fae313ca26045","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,284],[814,284],[814,333],[245,333]],"region":{"top_left_x":244,"top_left_y":283,"width":571,"height":51},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3f0b9bf0c134902b7b011123dd839f9","type":"text","conversion_output":true,"text":"- NRS pain score for both knees","text_display":"\n- NRS pain score for both knees","confidence":1,"confidence_rate":1},{"cnt":[[245,352],[1291,352],[1291,408],[245,408]],"region":{"top_left_x":244,"top_left_y":352,"width":1048,"height":57},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3bb0a4e8f3c64539a33e562e1e1ff59c","type":"text","conversion_output":true,"text":"- Collection of demographic characteristics (see Section 7.2)","text_display":"\n- Collection of demographic characteristics (see Section 7.2)","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1053,425],[1053,479],[245,479]],"region":{"top_left_x":244,"top_left_y":425,"width":809,"height":55},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"924686170c8347b5ab496bc016636593","type":"text","conversion_output":true,"text":"- Medical/medication history (see Section 7.2)","text_display":"\n- Medical/medication history (see Section 7.2)","confidence":0.9990234375,"confidence_rate":0.999980842543353},{"cnt":[[245,494],[1882,494],[1882,548],[245,548]],"region":{"top_left_x":244,"top_left_y":494,"width":1639,"height":54},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cedcfcc8ea354c5f98748641ef09d8b5","type":"text","conversion_output":true,"text":"Subjects will be asked to withhold all pain medications, including narcotics and paracetamol","text_display":"\n\nSubjects will be asked to withhold all pain medications, including narcotics and paracetamol","confidence":1,"confidence_rate":1},{"cnt":[[245,541],[1882,541],[1882,595],[245,595]],"region":{"top_left_x":244,"top_left_y":541,"width":1639,"height":55},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b15f2f43d72a4c6c8a4f54605045387a","type":"text","conversion_output":true,"text":"(acetaminophen) for 5 half-lives and a visit will be scheduled to continue screening. Aspirin","text_display":" (acetaminophen) for 5 half-lives and a visit will be scheduled to continue screening. Aspirin","confidence":1,"confidence_rate":1},{"cnt":[[245,591],[1880,591],[1880,642],[245,642]],"region":{"top_left_x":244,"top_left_y":590,"width":1636,"height":53},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d53953dd81240b5bc63cacaf9c05967","type":"text","conversion_output":true,"text":"(acetylsalicylic acid) used for cardiovascular protection does not need to be withheld, nor do","text_display":" (acetylsalicylic acid) used for cardiovascular protection does not need to be withheld, nor do","confidence":1,"confidence_rate":1},{"cnt":[[245,640],[1319,640],[1319,690],[245,690]],"region":{"top_left_x":244,"top_left_y":640,"width":1076,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1195283f778c42b1a1ef193f3a74e7b9","type":"text","conversion_output":true,"text":"antidepressants used for management of OA pain or depression.","text_display":" antidepressants used for management of OA pain or depression.","confidence":1,"confidence_rate":1},{"cnt":[[245,707],[1884,707],[1884,758],[245,758]],"region":{"top_left_x":244,"top_left_y":706,"width":1641,"height":53},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16769079477c4b7692cc9a0e5519ea64","type":"text","conversion_output":true,"text":"Subjects not taking analgesic medication at the time of informed consent signature can have Visit","text_display":"\n\nSubjects not taking analgesic medication at the time of informed consent signature can have Visit","confidence":1,"confidence_rate":1},{"cnt":[[247,756],[1085,756],[1085,810],[247,810]],"region":{"top_left_x":247,"top_left_y":756,"width":838,"height":54},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7d7d7b783c54333b691f94ef6dfc95c","type":"text","conversion_output":true,"text":"1a and 1b procedures completed at the same visit.","text_display":" 1a and 1b procedures completed at the same visit.","confidence":0.6214723270386457,"confidence_rate":0.99123009132328},{"cnt":[[236,842],[402,842],[402,904],[236,904]],"region":{"top_left_x":236,"top_left_y":842,"width":166,"height":63},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d8ddfc5249b4dee839e66f0b88b9711","type":"section_header","conversion_output":false,"children_ids":["92afd88368b14c8897b25c9b537a9c6a"],"text":"","text_display":""},{"cnt":[[245,846],[397,846],[397,900],[245,900]],"region":{"top_left_x":244,"top_left_y":846,"width":154,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92afd88368b14c8897b25c9b537a9c6a","type":"text","conversion_output":true,"parent_id":"9d8ddfc5249b4dee839e66f0b88b9711","text":"Visit 1b","text_display":"\n\n\\section*{Visit 1b}","confidence":1,"confidence_rate":1},{"cnt":[[245,932],[1882,932],[1882,986],[245,986]],"region":{"top_left_x":244,"top_left_y":932,"width":1639,"height":55},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee3a55444c3a49ac86932e853aa4a571","type":"text","conversion_output":true,"text":"The following procedures are to be performed in all subjects. Subjects taking analgesic","text_display":"\n\nThe following procedures are to be performed in all subjects. Subjects taking analgesic","confidence":1,"confidence_rate":1},{"cnt":[[245,984],[1880,984],[1880,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":983,"width":1636,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f54bd92ba564cbab1ef08881d253d81","type":"text","conversion_output":true,"text":"medications at the time of Visit 1a must undergo washout of all analgesic medications and","text_display":" medications at the time of Visit 1a must undergo washout of all analgesic medications and","confidence":0.99609375,"confidence_rate":0.9999583636399967},{"cnt":[[245,1031],[1880,1031],[1880,1081],[245,1081]],"region":{"top_left_x":244,"top_left_y":1031,"width":1636,"height":50},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4023a09d5162465995346caba3450391","type":"text","conversion_output":true,"text":"schedule a follow-up visit as described above. Subjects not taking analgesic medications can","text_display":" schedule a follow-up visit as described above. Subjects not taking analgesic medications can","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1491,1079],[1491,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1078,"width":1248,"height":55},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b5a82088a504ddc92b74d31434bb47b","type":"text","conversion_output":true,"text":"proceed with the following procedures at the time of the initial study visit.","text_display":" proceed with the following procedures at the time of the initial study visit.","confidence":1,"confidence_rate":1},{"cnt":[[245,1152],[1882,1152],[1882,1201],[245,1201]],"region":{"top_left_x":244,"top_left_y":1151,"width":1639,"height":50},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f3b32bfe5f5433380b770379252a2b1","type":"text","conversion_output":true,"text":"- WOMAC (Question 1 of the WOMAC pain index only; see Section 5.4 and Appendix C): this","text_display":"\n- WOMAC (Question 1 of the WOMAC pain index only; see Section 5.4 and Appendix C): this","confidence":1,"confidence_rate":1},{"cnt":[[294,1199],[1882,1199],[1882,1248],[294,1248]],"region":{"top_left_x":294,"top_left_y":1198,"width":1589,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00e2c6825b264d90ac07f69f93199bd5","type":"text","conversion_output":true,"text":"assessment should be done before any other procedures or examinations are performed and","text_display":" assessment should be done before any other procedures or examinations are performed and","confidence":1,"confidence_rate":1},{"cnt":[[294,1246],[1549,1246],[1549,1298],[294,1298]],"region":{"top_left_x":294,"top_left_y":1246,"width":1256,"height":52},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6e07622325a45dfbe41fe6c27ce375c","type":"text","conversion_output":true,"text":"completed for both knees, since the target knee has not yet been identified.","text_display":" completed for both knees, since the target knee has not yet been identified.","confidence":1,"confidence_rate":1},{"cnt":[[245,1319],[1171,1319],[1171,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1319,"width":927,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a267bede8be34dc7ab4b64faba3e296c","type":"text","conversion_output":true,"text":"- NRS pain score for the target and contralateral knee","text_display":"\n- NRS pain score for the target and contralateral knee","confidence":1,"confidence_rate":1},{"cnt":[[292,1388],[1882,1388],[1882,1437],[292,1437]],"region":{"top_left_x":292,"top_left_y":1387,"width":1591,"height":51},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44c1d5bcb16d4f4799f608321014873f","type":"text","conversion_output":true,"text":"NOTE: if Visit 1 a and 1 b are being combined do not repeat the WOMAC Question 1 or the","text_display":"\n\nNOTE: if Visit 1 a and 1 b are being combined do not repeat the WOMAC Question 1 or the","confidence":0.9767472079515755,"confidence_rate":0.9997670825397834},{"cnt":[[292,1435],[571,1435],[571,1485],[292,1485]],"region":{"top_left_x":292,"top_left_y":1435,"width":280,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0160825841c04c4296177f033a2def29","type":"text","conversion_output":true,"text":"NRS pain score.","text_display":" NRS pain score.","confidence":0.9931640625,"confidence_rate":0.9996570883301062},{"cnt":[[245,1508],[1528,1508],[1528,1558],[245,1558]],"region":{"top_left_x":244,"top_left_y":1508,"width":1284,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f37aefc97fa84032b57b2e941ba6106a","type":"text","conversion_output":true,"text":"- Review of AEs and concomitant medications (see Sections 7.4.1 and 6.5)","text_display":"\n- Review of AEs and concomitant medications (see Sections 7.4.1 and 6.5)","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1036,1577],[1036,1631],[245,1631]],"region":{"top_left_x":244,"top_left_y":1576,"width":792,"height":55},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fcb6b8a976054552a59f2e9a9722305f","type":"text","conversion_output":true,"text":"- Vital signs measurement (see Section 7.4.4)","text_display":"\n- Vital signs measurement (see Section 7.4.4)","confidence":1,"confidence_rate":1},{"cnt":[[245,1650],[1149,1650],[1149,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1650,"width":906,"height":54},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19379a509ebc4b109afdaa862ff602db","type":"text","conversion_output":true,"text":"- Physical examination, including height and weight","text_display":"\n- Physical examination, including height and weight","confidence":1,"confidence_rate":1},{"cnt":[[245,1723],[844,1723],[844,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1723,"width":601,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18a202f3102c4aeca85fa0ad7c8afae9","type":"text","conversion_output":true,"text":"- 12-lead ECG (see Section 7.4.4)","text_display":"\n- 12-lead ECG (see Section 7.4.4)","confidence":0.99658203125,"confidence_rate":0.9999099034444765},{"cnt":[[245,1794],[1880,1794],[1880,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1793,"width":1636,"height":53},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"900779232ffc4369a3d6aee95d8adb35","type":"text","conversion_output":true,"text":"- Sample collection for hematology, biochemistry, and urinalysis (see Section 7.4.3 and","text_display":"\n- Sample collection for hematology, biochemistry, and urinalysis (see Section 7.4.3 and","confidence":1,"confidence_rate":1},{"cnt":[[294,1841],[1880,1841],[1880,1893],[294,1893]],"region":{"top_left_x":294,"top_left_y":1841,"width":1586,"height":52},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7aec1f5110e406c83f6d682a411810c","type":"text","conversion_output":true,"text":"Appendix B): coagulation tests will also be performed during the screening period (to be done","text_display":" Appendix B): coagulation tests will also be performed during the screening period (to be done","confidence":1,"confidence_rate":1},{"cnt":[[294,1891],[440,1891],[440,1940],[294,1940]],"region":{"top_left_x":294,"top_left_y":1890,"width":147,"height":51},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"937cbdf8c92a4ca686800fc2219a6254","type":"text","conversion_output":true,"text":"locally).","text_display":" locally).","confidence":1,"confidence_rate":1},{"cnt":[[245,1962],[1278,1962],[1278,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1961,"width":1035,"height":53},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44a2a412c7e94435ae489d2eebe05a11","type":"text","conversion_output":true,"text":"- Serum pregnancy test for women of childbearing potential","text_display":"\n- Serum pregnancy test for women of childbearing potential","confidence":1,"confidence_rate":1},{"cnt":[[292,2030],[1880,2030],[1880,2082],[292,2082]],"region":{"top_left_x":292,"top_left_y":2030,"width":1588,"height":52},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92da96240ec64a4db7cfab86f42be55c","type":"text","conversion_output":true,"text":"NOTE: In women of childbearing potential, a negative serum pregnancy test must be obtained","text_display":"\n\nNOTE: In women of childbearing potential, a negative serum pregnancy test must be obtained","confidence":1,"confidence_rate":1},{"cnt":[[292,2080],[632,2080],[632,2129],[292,2129]],"region":{"top_left_x":292,"top_left_y":2079,"width":340,"height":51},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f53f276fde21465b933002a73d520452","type":"text","conversion_output":true,"text":"before knee X-rays.","text_display":" before knee X-rays.","confidence":1,"confidence_rate":1},{"cnt":[[245,2151],[935,2151],[935,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2150,"width":691,"height":53},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7732724c4cb24801b102b97c8e4ebf40","type":"text","conversion_output":true,"text":"- 20-meter walk test (see Section 7.3.5)","text_display":"\n- 20-meter walk test (see Section 7.3.5)","confidence":1,"confidence_rate":1},{"cnt":[[245,2221],[1882,2221],[1882,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2221,"width":1639,"height":50},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a268dc03ecb44f638b8ddbd70f2c103a","type":"text","conversion_output":true,"text":"- X-rays of both the target knee and the contralateral knee, plus a long-axis view of the target","text_display":"\n- X-rays of both the target knee and the contralateral knee, plus a long-axis view of the target","confidence":1,"confidence_rate":1},{"cnt":[[292,2269],[703,2269],[703,2318],[292,2318]],"region":{"top_left_x":292,"top_left_y":2268,"width":411,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cb95c0c21c946548450578fab560a41","type":"text","conversion_output":true,"text":"knee (see Section 7.3.4)","text_display":" knee (see Section 7.3.4)","confidence":1,"confidence_rate":1},{"cnt":[[245,2342],[829,2342],[829,2391],[245,2391]],"region":{"top_left_x":244,"top_left_y":2341,"width":586,"height":51},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e541bdb94cf4c6faeb129ba6f2c819e","type":"text","conversion_output":true,"text":"- Identification of the target knee","text_display":"\n- Identification of the target knee","confidence":1,"confidence_rate":1},{"cnt":[[245,2413],[1508,2413],[1508,2464],[245,2464]],"region":{"top_left_x":244,"top_left_y":2412,"width":1265,"height":53},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7b6edb765734dfbb6691c755ef6bfb7","type":"text","conversion_output":true,"text":"- Review of inclusion and exclusion criteria (see Sections 5.3.1 and 5.3.2)","text_display":"\n- Review of inclusion and exclusion criteria (see Sections 5.3.1 and 5.3.2)","confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3565f646d0d14fd6bcdc8cfec28081cf","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"58210725581a4367a73069b254542a4d","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ee6c66c59294ba2b4b40e5864de6810","type":"page_info","conversion_output":false,"text":"58/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-059","page":59,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0b26459fc2143708bced9f447bf270b","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4564f391a0ff4c27a40ae9d4fe94d2f5","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93820e4d9d254deab253ab5ea3eb9166","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f69bd1bb02df4ba2add7fc6af5871ca5","type":"text","conversion_output":true,"text":"These procedures can be spread out over the screening period if this is necessary for logistical","text_display":"\n\nThese procedures can be spread out over the screening period if this is necessary for logistical","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[243,329],[1880,329],[1880,380],[243,380]],"region":{"top_left_x":242,"top_left_y":328,"width":1638,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac276febb99a4c6f8b213b48befe0abb","type":"text","conversion_output":true,"text":"reasons. However, subject questionnaires (WOMAC Question 1, PGA, and NRS pain) must be","text_display":" reasons. However, subject questionnaires (WOMAC Question 1, PGA, and NRS pain) must be","confidence":1,"confidence_rate":1},{"cnt":[[245,378],[1880,378],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":1636,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff88bdfa85c54a2ba352f21612eca725","type":"text","conversion_output":true,"text":"done on the same day at the beginning of screening. Subjects must have a pain score for the","text_display":" done on the same day at the beginning of screening. Subjects must have a pain score for the","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1882,425],[1882,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1639,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ad2ee3d7dcb47d1addc9c44a2a05a17","type":"text","conversion_output":true,"text":"target knee of 4 to 9 points in response to Question 1 of the WOMAC pain index after drug","text_display":" target knee of 4 to 9 points in response to Question 1 of the WOMAC pain index after drug","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1412,473],[1412,524],[245,524]],"region":{"top_left_x":244,"top_left_y":472,"width":1168,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2600806862a14209af44f8513c690cbf","type":"text","conversion_output":true,"text":"washout at the time of Visit 1b to be eligible for continued screening.","text_display":" washout at the time of Visit 1b to be eligible for continued screening.","confidence":0.80322265625,"confidence_rate":0.997120950816164},{"cnt":[[245,559],[1882,559],[1882,612],[245,612]],"region":{"top_left_x":244,"top_left_y":558,"width":1639,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16a9733b079e4abcb0565bc6c52f7c81","type":"text","conversion_output":true,"text":"Subjects will again be asked to withhold all pain medications, including narcotics and","text_display":"\n\nSubjects will again be asked to withhold all pain medications, including narcotics and","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1863,610],[1863,662],[245,662]],"region":{"top_left_x":244,"top_left_y":610,"width":1619,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ffea5e88fb349fd9c5b6e3e452eac71","type":"text","conversion_output":true,"text":"paracetamol (acetaminophen) for 5 half-lives before the baseline WOMAC assessment (Visit 2).","text_display":" paracetamol (acetaminophen) for 5 half-lives before the baseline WOMAC assessment (Visit 2).","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1880,700],[1880,750],[245,750]],"region":{"top_left_x":244,"top_left_y":700,"width":1636,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b6f70ac1ded4287bd53074c890f95ce","type":"text","conversion_output":true,"text":"At the beginning of the screening period, subjects will be given trial diaries for recording of any","text_display":"\n\nAt the beginning of the screening period, subjects will be given trial diaries for recording of any","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[1880,748],[1880,797],[245,797]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35e578bd3a2c48afb223906ee3325a1b","type":"text","conversion_output":true,"text":"AEs occurring or concomitant medications used during screening and for recording of maximum","text_display":" AEs occurring or concomitant medications used during screening and for recording of maximum","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[1880,795],[1880,846],[245,846]],"region":{"top_left_x":244,"top_left_y":794,"width":1636,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a532ff05d5a0459eb1ccbb724600a2b8","type":"text","conversion_output":true,"text":"pain and presence or absence of joint swelling in the target knee on the day before the first IMP","text_display":" pain and presence or absence of joint swelling in the target knee on the day before the first IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[1102,842],[1102,896],[245,896]],"region":{"top_left_x":244,"top_left_y":842,"width":859,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bc91e449cff4d9b818c1b6ff5cee348","type":"text","conversion_output":true,"text":"administration (Week 0/Visit 2; see Section 7.1.1).","text_display":" administration (Week 0/Visit 2; see Section 7.1.1).","confidence":1,"confidence_rate":1},{"cnt":[[236,928],[1886,928],[1886,1055],[236,1055]],"region":{"top_left_x":236,"top_left_y":928,"width":1651,"height":127},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a8aa7030a5e405cb114ba8bf1ff9eca","type":"section_header","conversion_output":false,"children_ids":["713e3c0e1dea498096e0c808a29b7fa0","c42cfa291cbc4aaaa229d87ad827f9a5"],"text":"","text_display":""},{"cnt":[[243,932],[1884,932],[1884,993],[243,993]],"region":{"top_left_x":242,"top_left_y":932,"width":1643,"height":61},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"713e3c0e1dea498096e0c808a29b7fa0","type":"text","conversion_output":true,"parent_id":"4a8aa7030a5e405cb114ba8bf1ff9eca","text":"7.1.3 Double-Blind Placebo-Controlled Treatment Phase (Visits 2","text_display":"\n\n\\subsection*{7.1.3 Double-Blind Placebo-Controlled Treatment Phase (Visits 2","confidence":1,"confidence_rate":1},{"cnt":[[593,993],[724,993],[724,1051],[593,1051]],"region":{"top_left_x":592,"top_left_y":992,"width":133,"height":59},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c42cfa291cbc4aaaa229d87ad827f9a5","type":"text","conversion_output":true,"parent_id":"4a8aa7030a5e405cb114ba8bf1ff9eca","text":"to 22)","text_display":" to 22)}","confidence":1,"confidence_rate":1},{"cnt":[[243,1085],[1880,1085],[1880,1137],[243,1137]],"region":{"top_left_x":242,"top_left_y":1084,"width":1638,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3ae579ffb0e43eab2d6cfe89f0a5d08","type":"text","conversion_output":true,"text":"The duration of the DBPC treatment phase will be 2 years ( 104 weeks). Trial visits during this","text_display":"\n\nThe duration of the DBPC treatment phase will be 2 years ( 104 weeks). Trial visits during this","confidence":0.9951171875,"confidence_rate":0.999953823968252},{"cnt":[[243,1134],[1882,1134],[1882,1188],[243,1188]],"region":{"top_left_x":242,"top_left_y":1134,"width":1641,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c049504e329d4c3692798cafb1c93d92","type":"text","conversion_output":true,"text":"phase are outlined in Table 2, and details of the procedures to be performed are presented in","text_display":" phase are outlined in Table 2, and details of the procedures to be performed are presented in","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,1182],[466,1182],[466,1233],[245,1233]],"region":{"top_left_x":244,"top_left_y":1181,"width":223,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04e12f74f0ae4ea19c6ef5d8ea4c926f","type":"text","conversion_output":true,"text":"Appendix E.","text_display":" Appendix E.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f8e1fb422ba44bcaf4ddf04422e9bd5","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[391,2546],[391,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":148,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5d7dc5eba094266bb4c08048faf0028","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2527],[1603,2527],[1603,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2526,"width":95,"height":38},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f0b1dab093b45cf9788eee389f48a78","type":"page_info","conversion_output":false,"text":"59/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-060","page":60,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77e577d742b3426f851e49d350b3171e","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7bd45fd2854b40c78f5def2103ceefc0","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd7e0f4e1db14f3b951b524b94464e38","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1377,279],[1377,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1134,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a26b682ca1b432d8ac145258b7a335e","type":"figure_label","conversion_output":false,"text":"Table 2 Trial Visits during DBPC Treatment Phase","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,363],[1882,363],[1882,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":363,"width":1639,"height":1161},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b24d87e18ff4ffd987ad9c28d636e86","type":"table","conversion_output":true,"children_ids":["da6d4555a9af43e08b8f312e778dddb9","cfb12f4acd324053afa904184bf12b80","0c379922fc2d449583cb2ea745e2477a","4fea5a572ba240ffb90a9845f46dc5d1","fbafd269f71e42a8b38453900697fd51","b3f95220d40d437c85783d84fcfd94c1","8873842391bd4289a0bb135bc53212e2","6ad4584437ee47ffbb8b0904182aa58c","fe8f6b56ef8144d5b97c1a9721848bb3","4c943166993d471fa01171c3acb6232e","c24bfb44f2e14c689ec61ca7a2906fed","7aef15f6f6734c17a4dc8994522da400","53209a92e10845b086fead58eec844cb","f05afea395e9415a9399208b7b5cbba4","5f5bb2ad327c4cad8053e62a8a07bbe6","2b9ecae2e5ff43c99916cebd13dd9da5","b1c67ced8c7c431ca6234f490d41f59e","1acea0afe7be41b28dcabd4b868bfb2c","cb4af37511004c4aa312b81035ace752","48017fac1e464471b94080d5c16456f0","271376ea3a3447be892303dad7118363","13630114cefc46fa88c2ad4e57e12c15","4d7d0432c9d144248ab9b3ef0e5300dc","8538a9a0942a4ac3bbcec28a826e4b7f","cf53cbbf55814d798eefc779941f9645","7b9e7480162846dc85505d55daa4a9ac","8bcdd7e93ec046d99b25d092ac764505","7183a125d9e84fbd87e7dc27eb13d2e9","449ffee0c5994e9881d9083a7072acc8","8a0481fb60c740f28fd619668421025f","04a6a5dde5514c6b8201b3ea92a36d86","83dc16d5bb544da888b4067935c7001b","f5770e798477458cb9bc44a7f59f6f19","e980d9ecb6aa415f8a8a4a720b569078","05a63c3f36414ee8ada9094128a48dc7","6ba21913af75481291ce818cfca24654","3341c502ee3c4182b5f42486aae23433","52ab028a860849ef875478c5043ef134","789ba9a6f8d04653b25884f645926d2a","8b3baf97f3a741c5afe943cb17c19f87","38b4b03087a045e39ed739888c6e935e","426b1564a54043878fb703ba816c9eda","ec209a8014c34bb7a92634fa7e6e3d29","e7eea3479ce34cb891caefbf501017d5","94060c675c664a19976a590fca614628","cb5063e265a54c83a9a217d042e44fed","a8ed344f3a1e480385b9e5c09dc2d5b2","62c4bf654dc44c51b82fd546e9372563","3dc9772a3b41454cbba91bb3e14e4ba9","8dcd2a574a774cb78cf3e00a3dfb48a6","809f2a902fd44f28a2268b5f97ea9fa7","e9221be3430649138f9a39ff966014e0","8951c4945e004162a8afa565fa17870a","5974e614b65547d5b7c32bf43dbb10c9","6b3c8559aa83436494fba991f0a4736a","c46d8d2984054f098fa05de4f8b33452","c92eaa8025f140eb8503889de2848deb","c595bd14c2ba4872ae9b84a3d26cee4b","d82ab1e8f5814fea8622f0baf5717fe1","fd3401d20c314701b1a286c9b542ec2f","c07c827373b347ccbab3c6a748d0f836","eb4bc92208ad48c1a1d2a19887a1440b","ca271424a5af4f8bac14fc4ef528bf81","e82ece7bad654244b7b38fb222349142","c1222f99fc1e4aca9d424eac96891342","0236b02c3b5645ebb54d6f97bb1a2313","78cedbe0e7264cca9071d4a1f7eeac39","35cf3f4dd4c94de39bbdcf534c1d5421","37feb9ccd97040a2a93e561536a21b46","42c63ddddd85466bb677a81dd597b822","f086fd21b97347fbbd9838d1e625ffe7","0f6bb788f5e14a9fb2865e39c4cbc607","02955000b6034c84ae86a77d8f25754b","643dc385abbc4c95bd695edaaeccf9d3","aaf50799a5db4793a4dd1d6695eb21a1","f2b26eb3d8034e8394d5533e46e3ce7c","646cf392c24b4021b61b26b321125e38","6030cdacbec348558f20273acd2e5529","7824a1877ca04bd7a3cc43be44998ce9","79d04a74197f408b97d3b2709ac44b2d","0301e56bc4b54290b820a4b5d45bf703","342bdc893f05436ca220ce46ae11e459","8eaeadd0e7664ad48da16c955652df95","98611501321d460c9acf22e5adc856f1","07e0e3572c0e4c978e95e7d19b05966d","e2509055aefa4b2d88047392a356e1fe","25f5b200bf0c440a8c2f9f4461a14035","e9542436d92c4cc79f25feabf8f81959","b4c68c2a0a544339ad3ef34885e6d9e0","94a9045d459b47e8b182afd362684317","fcac8879555046e6b568efc608c37dff","132281fad5b04eb584c26eaa3bcb9c3e","e1762132bad54b04b0683c2b2bcf3a74"],"selected_labels":["6a26b682ca1b432d8ac145258b7a335e"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline Visit Number & Week* & Treatment & Visit Name or Type \\\\\n\\hline 2 & 0 & X & Baseline - Major Efficacy \\\\\n\\hline 3 & 1 & X & \\\\\n\\hline 4 & 2 & X & \\\\\n\\hline 5 & 3 & & \\\\\n\\hline 6 & 12 & & Minor Efficacy \\\\\n\\hline 7 & 26 & X & Major Efficacy \\\\\n\\hline 8 & 27 & X & \\\\\n\\hline 9 & 28 & X & \\\\\n\\hline 10 & 29 & & \\\\\n\\hline 11 & 38 & & Minor Efficacy \\\\\n\\hline 12 & 52 & X & Major Efficacy \\\\\n\\hline 13 & 53 & X & \\\\\n\\hline 14 & 54 & X & \\\\\n\\hline 15 & 55 & & \\\\\n\\hline 16 & 64 & & Minor Efficacy \\\\\n\\hline 17 & 78 & X & Major Efficacy \\\\\n\\hline 18 & 79 & X & \\\\\n\\hline 19 & 80 & X & \\\\\n\\hline 20 & 81 & & \\\\\n\\hline 21 & 90 & & Minor Efficacy \\\\\n\\hline 22 & 104 & & Major Efficacy \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 2 Trial Visits during DBPC Treatment Phase}\n\\begin{tabular}{|l|l|l|l|}\n\\hline Visit Number & Week* & Treatment & Visit Name or Type \\\\\n\\hline 2 & 0 & X & Baseline - Major Efficacy \\\\\n\\hline 3 & 1 & X & \\\\\n\\hline 4 & 2 & X & \\\\\n\\hline 5 & 3 & & \\\\\n\\hline 6 & 12 & & Minor Efficacy \\\\\n\\hline 7 & 26 & X & Major Efficacy \\\\\n\\hline 8 & 27 & X & \\\\\n\\hline 9 & 28 & X & \\\\\n\\hline 10 & 29 & & \\\\\n\\hline 11 & 38 & & Minor Efficacy \\\\\n\\hline 12 & 52 & X & Major Efficacy \\\\\n\\hline 13 & 53 & X & \\\\\n\\hline 14 & 54 & X & \\\\\n\\hline 15 & 55 & & \\\\\n\\hline 16 & 64 & & Minor Efficacy \\\\\n\\hline 17 & 78 & X & Major Efficacy \\\\\n\\hline 18 & 79 & X & \\\\\n\\hline 19 & 80 & X & \\\\\n\\hline 20 & 81 & & \\\\\n\\hline 21 & 90 & & Minor Efficacy \\\\\n\\hline 22 & 104 & & Major Efficacy \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":1,"confidence_rate":1},{"cnt":[[287,363],[500,363],[500,1524],[287,1524]],"region":{"top_left_x":287,"top_left_y":363,"width":213,"height":1161},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da6d4555a9af43e08b8f312e778dddb9","type":"table_column","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[621,363],[727,363],[727,1524],[621,1524]],"region":{"top_left_x":620,"top_left_y":363,"width":107,"height":1161},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfb12f4acd324053afa904184bf12b80","type":"table_column","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[985,363],[1151,363],[1151,1524],[985,1524]],"region":{"top_left_x":984,"top_left_y":363,"width":168,"height":1161},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c379922fc2d449583cb2ea745e2477a","type":"table_column","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[1340,363],[1747,363],[1747,1524],[1340,1524]],"region":{"top_left_x":1339,"top_left_y":363,"width":408,"height":1161},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fea5a572ba240ffb90a9845f46dc5d1","type":"table_column","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,380],[1883,380],[1883,426],[244,426]],"region":{"top_left_x":244,"top_left_y":380,"width":1640,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbafd269f71e42a8b38453900697fd51","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,441],[1883,441],[1883,486],[244,486]],"region":{"top_left_x":244,"top_left_y":440,"width":1640,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3f95220d40d437c85783d84fcfd94c1","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,491],[1883,491],[1883,532],[244,532]],"region":{"top_left_x":244,"top_left_y":490,"width":1640,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8873842391bd4289a0bb135bc53212e2","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,543],[1883,543],[1883,582],[244,582]],"region":{"top_left_x":244,"top_left_y":542,"width":1640,"height":40},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ad4584437ee47ffbb8b0904182aa58c","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,597],[1883,597],[1883,634],[244,634]],"region":{"top_left_x":244,"top_left_y":596,"width":1640,"height":38},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe8f6b56ef8144d5b97c1a9721848bb3","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,649],[1883,649],[1883,690],[244,690]],"region":{"top_left_x":244,"top_left_y":648,"width":1640,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c943166993d471fa01171c3acb6232e","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,699],[1883,699],[1883,740],[244,740]],"region":{"top_left_x":244,"top_left_y":698,"width":1640,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c24bfb44f2e14c689ec61ca7a2906fed","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,753],[1883,753],[1883,787],[244,787]],"region":{"top_left_x":244,"top_left_y":752,"width":1640,"height":36},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7aef15f6f6734c17a4dc8994522da400","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,805],[1883,805],[1883,839],[244,839]],"region":{"top_left_x":244,"top_left_y":804,"width":1640,"height":36},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53209a92e10845b086fead58eec844cb","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,857],[1883,857],[1883,889],[244,889]],"region":{"top_left_x":244,"top_left_y":856,"width":1640,"height":34},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f05afea395e9415a9399208b7b5cbba4","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,907],[1883,907],[1883,946],[244,946]],"region":{"top_left_x":244,"top_left_y":906,"width":1640,"height":40},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f5bb2ad327c4cad8053e62a8a07bbe6","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,959],[1883,959],[1883,1000],[244,1000]],"region":{"top_left_x":244,"top_left_y":958,"width":1640,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b9ecae2e5ff43c99916cebd13dd9da5","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1010],[1883,1010],[1883,1045],[244,1045]],"region":{"top_left_x":244,"top_left_y":1010,"width":1640,"height":36},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1c67ced8c7c431ca6234f490d41f59e","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1060],[1883,1060],[1883,1097],[244,1097]],"region":{"top_left_x":244,"top_left_y":1060,"width":1640,"height":38},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1acea0afe7be41b28dcabd4b868bfb2c","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1112],[1883,1112],[1883,1149],[244,1149]],"region":{"top_left_x":244,"top_left_y":1112,"width":1640,"height":38},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb4af37511004c4aa312b81035ace752","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1164],[1883,1164],[1883,1205],[244,1205]],"region":{"top_left_x":244,"top_left_y":1164,"width":1640,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48017fac1e464471b94080d5c16456f0","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1216],[1883,1216],[1883,1257],[244,1257]],"region":{"top_left_x":244,"top_left_y":1216,"width":1640,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"271376ea3a3447be892303dad7118363","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1268],[1883,1268],[1883,1305],[244,1305]],"region":{"top_left_x":244,"top_left_y":1268,"width":1640,"height":37},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13630114cefc46fa88c2ad4e57e12c15","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1320],[1883,1320],[1883,1355],[244,1355]],"region":{"top_left_x":244,"top_left_y":1320,"width":1640,"height":35},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d7d0432c9d144248ab9b3ef0e5300dc","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1372],[1883,1372],[1883,1407],[244,1407]],"region":{"top_left_x":244,"top_left_y":1372,"width":1640,"height":35},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8538a9a0942a4ac3bbcec28a826e4b7f","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1422],[1883,1422],[1883,1463],[244,1463]],"region":{"top_left_x":244,"top_left_y":1421,"width":1640,"height":43},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf53cbbf55814d798eefc779941f9645","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[244,1472],[1883,1472],[1883,1515],[244,1515]],"region":{"top_left_x":244,"top_left_y":1471,"width":1640,"height":45},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b9e7480162846dc85505d55daa4a9ac","type":"table_row","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"","text_display":""},{"cnt":[[292,385],[493,385],[493,417],[292,417]],"region":{"top_left_x":291,"top_left_y":384,"width":203,"height":34},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bcdd7e93ec046d99b25d092ac764505","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Visit Number","text_display":"Visit Number","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[621,385],[725,385],[725,417],[621,417]],"region":{"top_left_x":620,"top_left_y":384,"width":105,"height":34},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7183a125d9e84fbd87e7dc27eb13d2e9","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Week*","text_display":"Week*","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[989,385],[1151,385],[1151,417],[989,417]],"region":{"top_left_x":988,"top_left_y":384,"width":164,"height":34},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"449ffee0c5994e9881d9083a7072acc8","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Treatment","text_display":"Treatment","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1457,385],[1745,385],[1745,421],[1457,421]],"region":{"top_left_x":1456,"top_left_y":384,"width":289,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a0481fb60c740f28fd619668421025f","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Visit Name or Type","text_display":"Visit Name or Type","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[383,434],[409,434],[409,480],[383,480]],"region":{"top_left_x":382,"top_left_y":434,"width":27,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04a6a5dde5514c6b8201b3ea92a36d86","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"2","text_display":"2","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,434],[686,434],[686,480],[662,480]],"region":{"top_left_x":661,"top_left_y":434,"width":25,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83dc16d5bb544da888b4067935c7001b","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"0","text_display":"0","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,434],[1084,434],[1084,480],[1050,480]],"region":{"top_left_x":1049,"top_left_y":434,"width":36,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5770e798477458cb9bc44a7f59f6f19","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1344,445],[1701,445],[1701,482],[1344,482]],"region":{"top_left_x":1344,"top_left_y":445,"width":358,"height":38},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e980d9ecb6aa415f8a8a4a720b569078","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Baseline - Major Efficacy","text_display":"Baseline - Major Efficacy","cell_row":1,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[383,486],[409,486],[409,530],[383,530]],"region":{"top_left_x":382,"top_left_y":486,"width":27,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"05a63c3f36414ee8ada9094128a48dc7","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"3","text_display":"3","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[664,486],[686,486],[686,530],[664,530]],"region":{"top_left_x":664,"top_left_y":486,"width":22,"height":44},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ba21913af75481291ce818cfca24654","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"1","text_display":"1","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,486],[1086,486],[1086,530],[1050,530]],"region":{"top_left_x":1049,"top_left_y":486,"width":38,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3341c502ee3c4182b5f42486aae23433","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[383,538],[409,538],[409,580],[383,580]],"region":{"top_left_x":382,"top_left_y":538,"width":27,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52ab028a860849ef875478c5043ef134","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"4","text_display":"4","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[662,538],[690,538],[690,580],[662,580]],"region":{"top_left_x":661,"top_left_y":538,"width":30,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"789ba9a6f8d04653b25884f645926d2a","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"2","text_display":"2","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,538],[1084,538],[1084,580],[1050,580]],"region":{"top_left_x":1049,"top_left_y":538,"width":36,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b3baf97f3a741c5afe943cb17c19f87","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[383,590],[409,590],[409,632],[383,632]],"region":{"top_left_x":382,"top_left_y":590,"width":27,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38b4b03087a045e39ed739888c6e935e","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"5","text_display":"5","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[664,590],[686,590],[686,632],[664,632]],"region":{"top_left_x":664,"top_left_y":590,"width":22,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"426b1564a54043878fb703ba816c9eda","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"3","text_display":"3","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[383,645],[409,645],[409,683],[383,683]],"region":{"top_left_x":382,"top_left_y":644,"width":27,"height":40},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec209a8014c34bb7a92634fa7e6e3d29","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"6","text_display":"6","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,645],[699,645],[699,683],[647,683]],"region":{"top_left_x":646,"top_left_y":644,"width":53,"height":40},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7eea3479ce34cb891caefbf501017d5","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"12","text_display":"12","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1344,653],[1545,653],[1545,688],[1344,688]],"region":{"top_left_x":1344,"top_left_y":653,"width":202,"height":35},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94060c675c664a19976a590fca614628","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Minor Efficacy","text_display":"Minor Efficacy","cell_row":5,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[383,696],[409,696],[409,735],[383,735]],"region":{"top_left_x":382,"top_left_y":696,"width":27,"height":40},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb5063e265a54c83a9a217d042e44fed","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"7","text_display":"7","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,696],[699,696],[699,735],[647,735]],"region":{"top_left_x":646,"top_left_y":696,"width":53,"height":40},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8ed344f3a1e480385b9e5c09dc2d5b2","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"26","text_display":"26","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,696],[1084,696],[1084,735],[1050,735]],"region":{"top_left_x":1049,"top_left_y":696,"width":36,"height":40},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62c4bf654dc44c51b82fd546e9372563","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":6,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1344,701],[1545,701],[1545,740],[1344,740]],"region":{"top_left_x":1344,"top_left_y":700,"width":202,"height":40},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3dc9772a3b41454cbba91bb3e14e4ba9","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Major Efficacy","text_display":"Major Efficacy","cell_row":6,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[383,748],[409,748],[409,787],[383,787]],"region":{"top_left_x":382,"top_left_y":748,"width":27,"height":40},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dcd2a574a774cb78cf3e00a3dfb48a6","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"8","text_display":"8","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,748],[699,748],[699,787],[647,787]],"region":{"top_left_x":646,"top_left_y":748,"width":53,"height":40},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"809f2a902fd44f28a2268b5f97ea9fa7","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"27","text_display":"27","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,748],[1086,748],[1086,787],[1050,787]],"region":{"top_left_x":1049,"top_left_y":748,"width":38,"height":40},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9221be3430649138f9a39ff966014e0","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":7,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[383,803],[409,803],[409,839],[383,839]],"region":{"top_left_x":382,"top_left_y":802,"width":27,"height":38},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8951c4945e004162a8afa565fa17870a","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"9","text_display":"9","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,803],[699,803],[699,839],[647,839]],"region":{"top_left_x":646,"top_left_y":802,"width":53,"height":38},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5974e614b65547d5b7c32bf43dbb10c9","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"28","text_display":"28","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,803],[1086,803],[1086,839],[1050,839]],"region":{"top_left_x":1049,"top_left_y":802,"width":38,"height":38},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b3c8559aa83436494fba991f0a4736a","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":8,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,855],[417,855],[417,891],[367,891]],"region":{"top_left_x":367,"top_left_y":854,"width":51,"height":38},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c46d8d2984054f098fa05de4f8b33452","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"10","text_display":"10","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,855],[699,855],[699,891],[647,891]],"region":{"top_left_x":646,"top_left_y":854,"width":53,"height":38},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c92eaa8025f140eb8503889de2848deb","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"29","text_display":"29","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,907],[413,907],[413,943],[367,943]],"region":{"top_left_x":367,"top_left_y":906,"width":46,"height":38},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c595bd14c2ba4872ae9b84a3d26cee4b","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"11","text_display":"11","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,907],[699,907],[699,943],[647,943]],"region":{"top_left_x":646,"top_left_y":906,"width":53,"height":38},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d82ab1e8f5814fea8622f0baf5717fe1","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"38","text_display":"38","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1344,909],[1548,909],[1548,946],[1344,946]],"region":{"top_left_x":1344,"top_left_y":908,"width":204,"height":38},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd3401d20c314701b1a286c9b542ec2f","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Minor Efficacy","text_display":"Minor Efficacy","cell_row":10,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,959],[417,959],[417,995],[367,995]],"region":{"top_left_x":367,"top_left_y":958,"width":51,"height":38},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c07c827373b347ccbab3c6a748d0f836","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"12","text_display":"12","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,959],[699,959],[699,995],[647,995]],"region":{"top_left_x":646,"top_left_y":958,"width":53,"height":38},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb4bc92208ad48c1a1d2a19887a1440b","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"52","text_display":"52","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,959],[1086,959],[1086,995],[1050,995]],"region":{"top_left_x":1049,"top_left_y":958,"width":38,"height":38},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca271424a5af4f8bac14fc4ef528bf81","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":11,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1344,961],[1548,961],[1548,997],[1344,997]],"region":{"top_left_x":1344,"top_left_y":960,"width":204,"height":38},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e82ece7bad654244b7b38fb222349142","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Major Efficacy","text_display":"Major Efficacy","cell_row":11,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1013],[417,1013],[417,1047],[367,1047]],"region":{"top_left_x":367,"top_left_y":1012,"width":51,"height":36},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1222f99fc1e4aca9d424eac96891342","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"13","text_display":"13","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1013],[699,1013],[699,1047],[647,1047]],"region":{"top_left_x":646,"top_left_y":1012,"width":53,"height":36},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0236b02c3b5645ebb54d6f97bb1a2313","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"53","text_display":"53","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,1013],[1089,1013],[1089,1047],[1050,1047]],"region":{"top_left_x":1049,"top_left_y":1012,"width":40,"height":36},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78cedbe0e7264cca9071d4a1f7eeac39","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":12,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1065],[417,1065],[417,1099],[367,1099]],"region":{"top_left_x":367,"top_left_y":1064,"width":51,"height":36},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35cf3f4dd4c94de39bbdcf534c1d5421","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"14","text_display":"14","cell_row":13,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1065],[699,1065],[699,1099],[647,1099]],"region":{"top_left_x":646,"top_left_y":1064,"width":53,"height":36},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37feb9ccd97040a2a93e561536a21b46","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"54","text_display":"54","cell_row":13,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,1065],[1086,1065],[1086,1099],[1050,1099]],"region":{"top_left_x":1049,"top_left_y":1064,"width":38,"height":36},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42c63ddddd85466bb677a81dd597b822","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":13,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1117],[417,1117],[417,1151],[367,1151]],"region":{"top_left_x":367,"top_left_y":1116,"width":51,"height":36},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f086fd21b97347fbbd9838d1e625ffe7","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"15","text_display":"15","cell_row":14,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1117],[699,1117],[699,1151],[647,1151]],"region":{"top_left_x":646,"top_left_y":1116,"width":53,"height":36},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f6bb788f5e14a9fb2865e39c4cbc607","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"55","text_display":"55","cell_row":14,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1169],[417,1169],[417,1205],[367,1205]],"region":{"top_left_x":367,"top_left_y":1168,"width":51,"height":38},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02955000b6034c84ae86a77d8f25754b","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"16","text_display":"16","cell_row":15,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1164],[699,1164],[699,1205],[647,1205]],"region":{"top_left_x":646,"top_left_y":1164,"width":53,"height":42},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"643dc385abbc4c95bd695edaaeccf9d3","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"64","text_display":"64","cell_row":15,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1344,1164],[1548,1164],[1548,1201],[1344,1201]],"region":{"top_left_x":1344,"top_left_y":1164,"width":204,"height":38},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aaf50799a5db4793a4dd1d6695eb21a1","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Minor Efficacy","text_display":"Minor Efficacy","cell_row":15,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1221],[417,1221],[417,1257],[367,1257]],"region":{"top_left_x":367,"top_left_y":1220,"width":51,"height":38},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2b26eb3d8034e8394d5533e46e3ce7c","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"17","text_display":"17","cell_row":16,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1218],[699,1218],[699,1257],[647,1257]],"region":{"top_left_x":646,"top_left_y":1218,"width":53,"height":40},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"646cf392c24b4021b61b26b321125e38","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"78","text_display":"78","cell_row":16,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,1216],[1086,1216],[1086,1257],[1050,1257]],"region":{"top_left_x":1049,"top_left_y":1216,"width":38,"height":42},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6030cdacbec348558f20273acd2e5529","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":16,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1344,1216],[1548,1216],[1548,1255],[1344,1255]],"region":{"top_left_x":1344,"top_left_y":1216,"width":204,"height":40},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7824a1877ca04bd7a3cc43be44998ce9","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Major Efficacy","text_display":"Major Efficacy","cell_row":16,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1273],[417,1273],[417,1309],[367,1309]],"region":{"top_left_x":367,"top_left_y":1272,"width":51,"height":38},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79d04a74197f408b97d3b2709ac44b2d","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"18","text_display":"18","cell_row":17,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1270],[699,1270],[699,1309],[647,1309]],"region":{"top_left_x":646,"top_left_y":1270,"width":53,"height":40},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0301e56bc4b54290b820a4b5d45bf703","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"79","text_display":"79","cell_row":17,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,1268],[1086,1268],[1086,1309],[1050,1309]],"region":{"top_left_x":1049,"top_left_y":1268,"width":38,"height":42},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"342bdc893f05436ca220ce46ae11e459","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":17,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1320],[417,1320],[417,1361],[367,1361]],"region":{"top_left_x":367,"top_left_y":1320,"width":51,"height":42},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8eaeadd0e7664ad48da16c955652df95","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"19","text_display":"19","cell_row":18,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1320],[699,1320],[699,1361],[647,1361]],"region":{"top_left_x":646,"top_left_y":1320,"width":53,"height":42},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98611501321d460c9acf22e5adc856f1","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"80","text_display":"80","cell_row":18,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1050,1320],[1086,1320],[1086,1361],[1050,1361]],"region":{"top_left_x":1049,"top_left_y":1320,"width":38,"height":42},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07e0e3572c0e4c978e95e7d19b05966d","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"X","text_display":"X","cell_row":18,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1374],[417,1374],[417,1415],[367,1415]],"region":{"top_left_x":367,"top_left_y":1374,"width":51,"height":42},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2509055aefa4b2d88047392a356e1fe","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"20","text_display":"20","cell_row":19,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1372],[694,1372],[694,1415],[647,1415]],"region":{"top_left_x":646,"top_left_y":1372,"width":49,"height":44},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25f5b200bf0c440a8c2f9f4461a14035","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"81","text_display":"81","cell_row":19,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1424],[413,1424],[413,1467],[367,1467]],"region":{"top_left_x":367,"top_left_y":1424,"width":46,"height":44},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9542436d92c4cc79f25feabf8f81959","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"21","text_display":"21","cell_row":20,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1424],[699,1424],[699,1467],[647,1467]],"region":{"top_left_x":646,"top_left_y":1424,"width":53,"height":44},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4c68c2a0a544339ad3ef34885e6d9e0","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"90","text_display":"90","cell_row":20,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1344,1424],[1548,1424],[1548,1461],[1344,1461]],"region":{"top_left_x":1344,"top_left_y":1424,"width":204,"height":37},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94a9045d459b47e8b182afd362684317","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Minor Efficacy","text_display":"Minor Efficacy","cell_row":20,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[367,1476],[417,1476],[417,1519],[367,1519]],"region":{"top_left_x":367,"top_left_y":1476,"width":51,"height":44},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fcac8879555046e6b568efc608c37dff","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"22","text_display":"22","cell_row":21,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[647,1476],[705,1476],[705,1511],[647,1511]],"region":{"top_left_x":646,"top_left_y":1476,"width":60,"height":35},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"132281fad5b04eb584c26eaa3bcb9c3e","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"104","text_display":"104","cell_row":21,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1344,1476],[1548,1476],[1548,1513],[1344,1513]],"region":{"top_left_x":1344,"top_left_y":1476,"width":204,"height":37},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1762132bad54b04b0683c2b2bcf3a74","type":"simple_cell","conversion_output":false,"parent_id":"0b24d87e18ff4ffd987ad9c28d636e86","text":"Major Efficacy","text_display":"Major Efficacy","cell_row":21,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1777,1525],[1777,1566],[245,1566]],"region":{"top_left_x":244,"top_left_y":1525,"width":1533,"height":42},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9715c2fdf90040c79102b960ffa2a8cb","type":"text","conversion_output":true,"text":"* Relative to randomization and initiation of therapy at Week 0. Assessments performed at \"major\" and \"minor\"","text_display":"\n* Relative to randomization and initiation of therapy at Week 0. Assessments performed at \"major\" and \"minor\"","confidence":0.36829185485839844,"confidence_rate":0.9912761738365006},{"cnt":[[245,1560],[1248,1560],[1248,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1559,"width":1005,"height":42},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0b519ed03d14a84b963f8b19c1304dc","type":"text","conversion_output":true,"text":"efficacy visits are described in Sections 7.1.3.3 and 7.1.3.4 respectively.","text_display":" efficacy visits are described in Sections 7.1.3.3 and 7.1.3.4 respectively.","confidence":0.9931671619415283,"confidence_rate":0.9999143000626893},{"cnt":[[245,1641],[1880,1641],[1880,1691],[245,1691]],"region":{"top_left_x":244,"top_left_y":1641,"width":1636,"height":50},"line":101,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e20ce6c5cf504ae49cc8740992748a08","type":"text","conversion_output":true,"text":"Subject eligibility for the trial will be confirmed at the baseline visit (Week 0/Visit 2; see Section","text_display":"\n\nSubject eligibility for the trial will be confirmed at the baseline visit (Week 0/Visit 2; see Section","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1882,1689],[1882,1738],[245,1738]],"region":{"top_left_x":244,"top_left_y":1688,"width":1639,"height":51},"line":102,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a128d31ef284e599c34fbce9bd902e3","type":"text","conversion_output":true,"text":"7.1.3.1) based on scores for Question 1 of the WOMAC pain index at screening and baseline (see","text_display":" 7.1.3.1) based on scores for Question 1 of the WOMAC pain index at screening and baseline (see","confidence":1,"confidence_rate":1},{"cnt":[[245,1736],[1880,1736],[1880,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1735,"width":1636,"height":55},"line":103,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e799c8d274c4b5f98ba74ef796a2c8d","type":"text","conversion_output":true,"text":"Section 5.4). Eligible subjects will then be randomized and the first i.a. injection of IMP will be","text_display":" Section 5.4). Eligible subjects will then be randomized and the first i.a. injection of IMP will be","confidence":0.9975605006329715,"confidence_rate":0.9999765148931471},{"cnt":[[245,1783],[479,1783],[479,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1783,"width":236,"height":46},"line":104,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75604afa5b4d466093883adbd828347e","type":"text","conversion_output":true,"text":"administered.","text_display":" administered.","confidence":1,"confidence_rate":1},{"cnt":[[245,1873],[1880,1873],[1880,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1873,"width":1636,"height":55},"line":105,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ffa7a9fb9df4e72896bb71e48081f9f","type":"text","conversion_output":true,"text":"I.a. injections of the IMP will be administered at the baseline visit (Week 0/Visit 2) and at the","text_display":"\nI.a. injections of the IMP will be administered at the baseline visit (Week 0/Visit 2) and at the","confidence":0.978048081160523,"confidence_rate":0.9997824114462655},{"cnt":[[245,1921],[827,1921],[827,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":584,"height":46},"line":106,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e88cbf0f93264b09934896357baebf5b","type":"text","conversion_output":true,"text":"visits identified in Section 7.1.3.2.","text_display":" visits identified in Section 7.1.3.2.","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1880,2011],[1880,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2010,"width":1636,"height":55},"line":107,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39dc674add0b43a9ad4db8ff5ddf0936","type":"text","conversion_output":true,"text":"Major efficacy assessments will take place at intervals of 6 months, at the beginning of each","text_display":"\n\nMajor efficacy assessments will take place at intervals of 6 months, at the beginning of each","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1880,2058],[1880,2110],[245,2110]],"region":{"top_left_x":244,"top_left_y":2058,"width":1636,"height":52},"line":108,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6834c56adbf94be7a3e973ecc321fa90","type":"text","conversion_output":true,"text":"treatment cycle and at the end of the DBPC treatment phase (Week 104/Visit 22; see Section","text_display":" treatment cycle and at the end of the DBPC treatment phase (Week 104/Visit 22; see Section","confidence":1,"confidence_rate":1},{"cnt":[[245,2110],[393,2110],[393,2157],[245,2157]],"region":{"top_left_x":244,"top_left_y":2109,"width":150,"height":49},"line":109,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d29fff13ff464d2fa40e3ed7a5580b25","type":"text","conversion_output":true,"text":"7.1.3.3).","text_display":" 7.1.3.3).","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1882,2196],[1882,2247],[245,2247]],"region":{"top_left_x":244,"top_left_y":2195,"width":1639,"height":53},"line":110,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6db30d05d8af4b388660541e390845e1","type":"text","conversion_output":true,"text":"Minor efficacy assessments will also take place at intervals of 6 months, occurring 9 weeks after","text_display":"\n\nMinor efficacy assessments will also take place at intervals of 6 months, occurring 9 weeks after","confidence":0.994631290435791,"confidence_rate":0.9999501570489157},{"cnt":[[245,2243],[1137,2243],[1137,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2242,"width":893,"height":55},"line":111,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec068f77ef074d4f844034dad6b808e0","type":"text","conversion_output":true,"text":"the end of each treatment cycle (see Section 7.1.3.4).","text_display":" the end of each treatment cycle (see Section 7.1.3.4).","confidence":1,"confidence_rate":1},{"cnt":[[245,2333],[1880,2333],[1880,2385],[245,2385]],"region":{"top_left_x":244,"top_left_y":2333,"width":1636,"height":52},"line":112,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48ed5a4536544678a1c845d368639f9f","type":"text","conversion_output":true,"text":"Subjects will be requested to discontinue the intake of all pain medications for 5 half-lives before","text_display":"\n\nSubjects will be requested to discontinue the intake of all pain medications for 5 half-lives before","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,2380],[1880,2380],[1880,2434],[245,2434]],"region":{"top_left_x":244,"top_left_y":2380,"width":1636,"height":55},"line":113,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60c9fe69723a4485ba351b52d02d05c3","type":"text","conversion_output":true,"text":"a visit involving completion of the WOMAC (see Sections 5.4 and 7.1.2). At least 3 days before","text_display":" a visit involving completion of the WOMAC (see Sections 5.4 and 7.1.2). At least 3 days before","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,2430],[1880,2430],[1880,2481],[245,2481]],"region":{"top_left_x":244,"top_left_y":2429,"width":1636,"height":53},"line":114,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c947c76b0c0c4e428dbf24d84387699c","type":"text","conversion_output":true,"text":"each such visit, subjects will be contacted by phone to remind them of this requirement. When","text_display":" each such visit, subjects will be contacted by phone to remind them of this requirement. When","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":115,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f17ae456e3f042ecb3bab2cddb8cc486","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":116,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e73018590c5146e785d9739a2d088f98","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2522],[1601,2522],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2522,"width":93,"height":42},"line":117,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b167fc8cc3774871957578c38a6de98f","type":"page_info","conversion_output":false,"text":"60/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1794,2499],[1904,2499],[1904,2608],[1794,2608]],"region":{"top_left_x":1793,"top_left_y":2498,"width":111,"height":111},"line":118,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"326099c345d5440197de6a50a6286fe4","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.94775390625,"confidence_rate":0.9910964727518203}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-061","page":61,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"242af3f7fc4c482986219816d97e0a0c","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eef1de2821314ecaa155aa2e88b70c04","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83ded4c14a3e4b159937d4fd22a9bc75","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b69cc38bf514aeaa4a3838ff9640418","type":"text","conversion_output":true,"text":"the upcoming visit includes injection of IMP, this phone contact will include a reminder to","text_display":"\nthe upcoming visit includes injection of IMP, this phone contact will include a reminder to","confidence":1,"confidence_rate":1},{"cnt":[[245,327],[1850,327],[1850,380],[245,380]],"region":{"top_left_x":244,"top_left_y":326,"width":1606,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"553498dc64734f2eb72637888a05c08c","type":"text","conversion_output":true,"text":"complete trial diary information about target knee pain and swelling for the day before the visit.","text_display":" complete trial diary information about target knee pain and swelling for the day before the visit.","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1880,417],[1880,468],[245,468]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2928f159b81c475e9824de43864db312","type":"text","conversion_output":true,"text":"Vital signs measurement (see Section 7.4.4) and review of AEs and concomitant medications","text_display":"\n\nVital signs measurement (see Section 7.4.4) and review of AEs and concomitant medications","confidence":1,"confidence_rate":1},{"cnt":[[245,464],[1618,464],[1618,518],[245,518]],"region":{"top_left_x":244,"top_left_y":464,"width":1374,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53f981b7ba0c46c0a3829e0e139a2b8f","type":"text","conversion_output":true,"text":"(see Sections 7.4.1 and 6.5) will be performed at all DBPC treatment phase visits.","text_display":" (see Sections 7.4.1 and 6.5) will be performed at all DBPC treatment phase visits.","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[243,554],[1880,554],[1880,608],[243,608]],"region":{"top_left_x":242,"top_left_y":554,"width":1638,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da0ddac445ba4c28a6d7cbe942147669","type":"text","conversion_output":true,"text":"For women of childbearing potential, urine pregnancy tests will be performed before dosing on","text_display":"\n\nFor women of childbearing potential, urine pregnancy tests will be performed before dosing on","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[930,602],[930,655],[245,655]],"region":{"top_left_x":244,"top_left_y":601,"width":687,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b40388d2ab441f88164b1e8070a75ce","type":"text","conversion_output":true,"text":"each treatment day (see Section 7.1.3.3).","text_display":" each treatment day (see Section 7.1.3.3).","confidence":1,"confidence_rate":1},{"cnt":[[243,692],[1880,692],[1880,746],[243,746]],"region":{"top_left_x":242,"top_left_y":691,"width":1638,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad40f047a7564264ba14e8b210e7a07e","type":"text","conversion_output":true,"text":"Blood samples will be collected for testing for antibodies to sprifermin/FGF-18 at the baseline","text_display":"\n\nBlood samples will be collected for testing for antibodies to sprifermin/FGF-18 at the baseline","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,741],[1884,741],[1884,793],[245,793]],"region":{"top_left_x":244,"top_left_y":741,"width":1641,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c201937c81f4ecd903ae61ec3d5b796","type":"text","conversion_output":true,"text":"visit and at major efficacy visits (see Section 7.1.3.3), and also one week after the last dose of","text_display":" visit and at major efficacy visits (see Section 7.1.3.3), and also one week after the last dose of","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[1485,786],[1485,840],[245,840]],"region":{"top_left_x":244,"top_left_y":786,"width":1241,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45eee093eb484125b07c57ac4ef6907e","type":"text","conversion_output":true,"text":"each treatment cycle (at Weeks 3, 29, 55, and 81/Visits 5, 10, 15, and 20).","text_display":" each treatment cycle (at Weeks 3, 29, 55, and 81/Visits 5, 10, 15, and 20).","confidence":0.5877013703881362,"confidence_rate":0.9933778197505825},{"cnt":[[245,877],[1880,877],[1880,930],[245,930]],"region":{"top_left_x":244,"top_left_y":876,"width":1636,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fec96ff7ce042389db07ef8a0acdb69","type":"text","conversion_output":true,"text":"Blood samples will be collected for PK analysis at the baseline visit (Week 0/Visit 2), at the end","text_display":"\n\nBlood samples will be collected for PK analysis at the baseline visit (Week 0/Visit 2), at the end","confidence":1,"confidence_rate":1},{"cnt":[[245,924],[1880,924],[1880,978],[245,978]],"region":{"top_left_x":244,"top_left_y":923,"width":1636,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e0160f35f2a43a485a68d7663f3283e","type":"text","conversion_output":true,"text":"of each treatment cycle (Weeks 2, 28, 54, and 80/Visits 4, 9, 14, and 19), and at the end of the","text_display":" of each treatment cycle (Weeks 2, 28, 54, and 80/Visits 4, 9, 14, and 19), and at the end of the","confidence":0.668817653290108,"confidence_rate":0.9960253079819715},{"cnt":[[245,973],[1880,973],[1880,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":973,"width":1636,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d47fb86cdad24e5392685130b18d7495","type":"text","conversion_output":true,"text":"DBPC treatment phase (Week 104/Visit 22). PK samples will be taken pre-injection at baseline","text_display":" DBPC treatment phase (Week 104/Visit 22). PK samples will be taken pre-injection at baseline","confidence":0.9990234375,"confidence_rate":0.9999899274770393},{"cnt":[[245,1023],[1493,1023],[1493,1074],[245,1074]],"region":{"top_left_x":244,"top_left_y":1022,"width":1250,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13b72aaf71d74af081d34afc1e3c4054","type":"text","conversion_output":true,"text":"and 2 hours post-injection at subsequent visits where IMP is administered.","text_display":" and 2 hours post-injection at subsequent visits where IMP is administered.","confidence":1,"confidence_rate":1},{"cnt":[[245,1111],[1880,1111],[1880,1162],[245,1162]],"region":{"top_left_x":244,"top_left_y":1110,"width":1636,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71693eeac0fa42b08987149df5e3cd27","type":"text","conversion_output":true,"text":"Fasting blood and urine samples for biomarker analysis will be collected at the baseline visit","text_display":"\n\nFasting blood and urine samples for biomarker analysis will be collected at the baseline visit","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1160],[1880,1160],[1880,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1160,"width":1636,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c8230bb08d444fe942aa78e412660aa","type":"text","conversion_output":true,"text":"(Week 0/Visit 2) and at other visits (see Appendix E). For time points where IMP injections are","text_display":" (Week 0/Visit 2) and at other visits (see Appendix E). For time points where IMP injections are","confidence":1,"confidence_rate":1},{"cnt":[[245,1207],[1880,1207],[1880,1259],[245,1259]],"region":{"top_left_x":244,"top_left_y":1207,"width":1636,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d00a779db154ecebc9bdc77d0e84d20","type":"text","conversion_output":true,"text":"administered, samples will be collected pre-dose. For urine, second morning void samples should","text_display":" administered, samples will be collected pre-dose. For urine, second morning void samples should","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1255],[458,1255],[458,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1254,"width":214,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"096ba99a9d474e5d95a42a817ea7b3a8","type":"text","conversion_output":true,"text":"be obtained.","text_display":" be obtained.","confidence":1,"confidence_rate":1},{"cnt":[[245,1345],[1766,1345],[1766,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1344,"width":1523,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5b01a2d4ae74887b080309d2100ca3a","type":"text","conversion_output":true,"text":"12-lead ECGs will be performed at Week 52 (Visit 12; pre-dose) and Week 104 (Visit 22).","text_display":"\n\n12-lead ECGs will be performed at Week 52 (Visit 12; pre-dose) and Week 104 (Visit 22).","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[245,1435],[1880,1435],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1435,"width":1636,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a0901e81c30412bbbe740fd3f90f222","type":"text","conversion_output":true,"text":"At each visit, subjects will be given trial diaries for recording of any AEs occurring or","text_display":"\nAt each visit, subjects will be given trial diaries for recording of any AEs occurring or","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1880,1482],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1482,"width":1636,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f9e4b6e9c7c4744971b9776b90733cf","type":"text","conversion_output":true,"text":"concomitant medications used between visits and for recording of maximum pain and presence","text_display":" concomitant medications used between visits and for recording of maximum pain and presence","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1880,1530],[1880,1583],[245,1583]],"region":{"top_left_x":244,"top_left_y":1529,"width":1636,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca6a8eb02e53471889f07108c9905866","type":"text","conversion_output":true,"text":"or absence of joint swelling in the target knee for the day before and the 3 days after each IMP","text_display":" or absence of joint swelling in the target knee for the day before and the 3 days after each IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1747,1577],[1747,1631],[245,1631]],"region":{"top_left_x":244,"top_left_y":1576,"width":1503,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd1a2f97699c445c83aa8076b98a3efc","type":"text","conversion_output":true,"text":"injection (see Section 7.1.1). Diaries will be collected and reviewed at the following visit.","text_display":" injection (see Section 7.1.1). Diaries will be collected and reviewed at the following visit.","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[241,1663],[1257,1663],[1257,1734],[241,1734]],"region":{"top_left_x":240,"top_left_y":1662,"width":1017,"height":72},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bde3f9a60724475805ffc48ac2dcbb1","type":"section_header","conversion_output":false,"children_ids":["0000da5a97db4f0bac552cf57ee043c4"],"text":"","text_display":""},{"cnt":[[245,1671],[1248,1671],[1248,1729],[245,1729]],"region":{"top_left_x":244,"top_left_y":1671,"width":1005,"height":59},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0000da5a97db4f0bac552cf57ee043c4","type":"text","conversion_output":true,"parent_id":"4bde3f9a60724475805ffc48ac2dcbb1","text":"7.1.3.1 Baseline Visit (Week 0; Visit 2)","text_display":"\n\n\\subsection*{7.1.3.1 Baseline Visit (Week 0; Visit 2)}","confidence":1,"confidence_rate":1},{"cnt":[[245,1766],[1880,1766],[1880,1815],[245,1815]],"region":{"top_left_x":244,"top_left_y":1766,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aff1e1f575ef4003b513b499a36d2a65","type":"text","conversion_output":true,"text":"The baseline visit must take place within 42 days after the beginning of screening, following the","text_display":"\n\nThe baseline visit must take place within 42 days after the beginning of screening, following the","confidence":1,"confidence_rate":1},{"cnt":[[245,1813],[1721,1813],[1721,1867],[245,1867]],"region":{"top_left_x":244,"top_left_y":1813,"width":1477,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbfafab5386b42cc8cac2f42646c6669","type":"text","conversion_output":true,"text":"pain medication washout necessary for confirmation of trial eligibility (see Section 5.4).","text_display":" pain medication washout necessary for confirmation of trial eligibility (see Section 5.4).","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1880,1904],[1880,1953],[245,1953]],"region":{"top_left_x":244,"top_left_y":1903,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc530b34dd894df9873c9e71099a892f","type":"text","conversion_output":true,"text":"The following procedures will be performed at the baseline visit before administration of IMP.","text_display":"\n\nThe following procedures will be performed at the baseline visit before administration of IMP.","confidence":1,"confidence_rate":1},{"cnt":[[245,1951],[1880,1951],[1880,2004],[245,2004]],"region":{"top_left_x":244,"top_left_y":1950,"width":1636,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6eba51853324f5e9ac2e9a4bdf8c317","type":"text","conversion_output":true,"text":"Subject questionnaires (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, NRS pain score","text_display":" Subject questionnaires (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, NRS pain score","confidence":1,"confidence_rate":1},{"cnt":[[245,2000],[1880,2000],[1880,2052],[245,2052]],"region":{"top_left_x":244,"top_left_y":2000,"width":1636,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fab02d307bb649bfb82074cc65c23bd9","type":"text","conversion_output":true,"text":"in the target and contralateral knee, pain in other joints, MOS SF-36, and ICOAP) should be","text_display":" in the target and contralateral knee, pain in other joints, MOS SF-36, and ICOAP) should be","confidence":1,"confidence_rate":1},{"cnt":[[245,2047],[1841,2047],[1841,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2047,"width":1598,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed6a112411174687967c626e45485c2b","type":"text","conversion_output":true,"text":"completed before any other procedures are performed; the WOMAC should be completed first.","text_display":" completed before any other procedures are performed; the WOMAC should be completed first.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":34,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"21d657719912475fa06abe315d2f0cf9","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":35,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5daa7f23c9c74a67ac0397c64676dd40","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":36,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"871b62c959154a46bd7a33c61a710c64","type":"page_info","conversion_output":false,"text":"61/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2610],[1796,2610]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":111},"line":37,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"6483685881b743428d9d900ce2dee814","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.9990234375,"confidence_rate":0.9998371733163992}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-062","page":62,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff8ced40cd014fffa70fe9b44909a35e","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dedd82f917d5424092960e4a6ad06c98","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e20638590484aae86f7c0baf0c7d310","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,301],[776,301],[776,357],[245,357]],"region":{"top_left_x":244,"top_left_y":300,"width":532,"height":57},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12ceb414045949669b775a160e355506","type":"text","conversion_output":true,"text":"- WOMAC (see Appendix C)","text_display":"\n- WOMAC (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[707,374],[707,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":463,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c66b87352b849a4b204b3f0503f35fd","type":"text","conversion_output":true,"text":"- PGA (see Section 7.3.3)","text_display":"\n- PGA (see Section 7.3.3)","confidence":1,"confidence_rate":1},{"cnt":[[245,447],[821,447],[821,501],[245,501]],"region":{"top_left_x":244,"top_left_y":446,"width":577,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2190ba4c4b664d309127e7e2647ea6fa","type":"text","conversion_output":true,"text":"- KOOS QOL (see Appendix D)","text_display":"\n- KOOS QOL (see Appendix D)","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1001,520],[1001,574],[245,574]],"region":{"top_left_x":244,"top_left_y":519,"width":758,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a46e4597cdcd42e38706610976cb3c96","type":"text","conversion_output":true,"text":"- KOOS Symptom Index (see Appendix D)","text_display":"\n- KOOS Symptom Index (see Appendix D)","confidence":0.99951171875,"confidence_rate":0.9999883714843234},{"cnt":[[245,591],[788,591],[788,642],[245,642]],"region":{"top_left_x":244,"top_left_y":590,"width":545,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29a29e29c2494f04b787a1b7f8358f13","type":"text","conversion_output":true,"text":"- NRS pain (see Section 7.7.5)","text_display":"\n- NRS pain (see Section 7.7.5)","confidence":1,"confidence_rate":1},{"cnt":[[245,662],[920,662],[920,715],[245,715]],"region":{"top_left_x":244,"top_left_y":661,"width":676,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"704468965673459b9ebfb2d464cbfabe","type":"text","conversion_output":true,"text":"- Pain in other joints (see Appendix F)","text_display":"\n- Pain in other joints (see Appendix F)","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[810,735],[810,788],[245,788]],"region":{"top_left_x":244,"top_left_y":734,"width":566,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d4ac19f71fb4555acbefaebc331ec84","type":"text","conversion_output":true,"text":"- MOS SF-36 (see Appendix C)","text_display":"\n- MOS SF-36 (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,808],[733,808],[733,862],[245,862]],"region":{"top_left_x":244,"top_left_y":807,"width":489,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bf417f5feb94106b4162eec4e20492a","type":"text","conversion_output":true,"text":"- ICOAP (see Appendix C)","text_display":"\n- ICOAP (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,877],[1528,877],[1528,930],[245,930]],"region":{"top_left_x":244,"top_left_y":876,"width":1284,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cd637d1a72f42cdb6a8fb2120307d7d","type":"text","conversion_output":true,"text":"- Review of AEs and concomitant medications (see Sections 7.4 .1 and 6.5)","text_display":"\n- Review of AEs and concomitant medications (see Sections 7.4 .1 and 6.5)","confidence":0.4047955788821582,"confidence_rate":0.988758994072042},{"cnt":[[245,950],[1046,950],[1046,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":949,"width":803,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b38f28dc8a994f72a90496efd269425e","type":"text","conversion_output":true,"text":"- Review of subject diaries (see Section 7.1.1)","text_display":"\n- Review of subject diaries (see Section 7.1.1)","confidence":1,"confidence_rate":1},{"cnt":[[245,1023],[1038,1023],[1038,1074],[245,1074]],"region":{"top_left_x":244,"top_left_y":1022,"width":794,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a5447067b20462881b72301bc7f3d44","type":"text","conversion_output":true,"text":"- Vital signs measurement (see Section 7.4.4)","text_display":"\n- Vital signs measurement (see Section 7.4.4)","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[1882,1091],[1882,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1091,"width":1639,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f28c0699e8149d38ece2764591e19bb","type":"text","conversion_output":true,"text":"- Sample collection for hematology, biochemistry, and urinalysis (see Section 7.4.3 and","text_display":"\n- Sample collection for hematology, biochemistry, and urinalysis (see Section 7.4.3 and","confidence":1,"confidence_rate":1},{"cnt":[[292,1143],[520,1143],[520,1192],[292,1192]],"region":{"top_left_x":292,"top_left_y":1142,"width":228,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1ae48e7ac74422a9a1a7f1ce146abfd","type":"text","conversion_output":true,"text":"Appendix B)","text_display":" Appendix B)","confidence":1,"confidence_rate":1},{"cnt":[[245,1212],[1693,1212],[1693,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1211,"width":1449,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c37a280d0b2f48bbb1a394354c5abec1","type":"text","conversion_output":true,"text":"- Blood collection for testing for antibodies to sprifermin/FGF-18 (see Section 7.4.3)","text_display":"\n- Blood collection for testing for antibodies to sprifermin/FGF-18 (see Section 7.4.3)","confidence":1,"confidence_rate":1},{"cnt":[[245,1285],[1171,1285],[1171,1336],[245,1336]],"region":{"top_left_x":244,"top_left_y":1284,"width":927,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5605605637ad4d289de072564f1060d1","type":"text","conversion_output":true,"text":"- Blood collection for PK analysis (see Section 7.5.1)","text_display":"\n- Blood collection for PK analysis (see Section 7.5.1)","confidence":1,"confidence_rate":1},{"cnt":[[245,1358],[1437,1358],[1437,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1357,"width":1194,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ceaedfd8fde4d63b1937415af4e6653","type":"text","conversion_output":true,"text":"- Blood collection (fasting) for biomarker analysis (see Section 7.6.2)","text_display":"\n- Blood collection (fasting) for biomarker analysis (see Section 7.6.2)","confidence":1,"confidence_rate":1},{"cnt":[[245,1429],[1880,1429],[1880,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1428,"width":1636,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e445386a2c5444782064a15302537e1","type":"text","conversion_output":true,"text":"- Blood collection for optional PGt analyses (for subjects who have signed the PGt informed","text_display":"\n- Blood collection for optional PGt analyses (for subjects who have signed the PGt informed","confidence":1,"confidence_rate":1},{"cnt":[[294,1478],[1880,1478],[1880,1528],[294,1528]],"region":{"top_left_x":294,"top_left_y":1478,"width":1586,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6cd7fd5143d2470bad66df0a5d725919","type":"text","conversion_output":true,"text":"consent). If a blood sample cannot be obtained at the baseline visit, this sample can be taken","text_display":" consent). If a blood sample cannot be obtained at the baseline visit, this sample can be taken","confidence":1,"confidence_rate":1},{"cnt":[[292,1525],[1012,1525],[1012,1575],[292,1575]],"region":{"top_left_x":292,"top_left_y":1525,"width":720,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f74cdb2485db42bc87b5335fbd3dba1d","type":"text","conversion_output":true,"text":"at any subsequent visit (see Section 7.6.3).","text_display":" at any subsequent visit (see Section 7.6.3).","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1669,1594],[1669,1648],[245,1648]],"region":{"top_left_x":244,"top_left_y":1594,"width":1426,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24b7b6ce0fa6477da24dfbf819f50dc9","type":"text","conversion_output":true,"text":"- Urine collection (second morning void) for biomarker analysis (see Section 7.6.2)","text_display":"\n- Urine collection (second morning void) for biomarker analysis (see Section 7.6.2)","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[1265,1667],[1265,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1667,"width":1022,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db03f80fdadd47ae870dc4e12ca52c38","type":"text","conversion_output":true,"text":"- Urine pregnancy test for women of childbearing potential","text_display":"\n- Urine pregnancy test for women of childbearing potential","confidence":1,"confidence_rate":1},{"cnt":[[245,1740],[935,1740],[935,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1740,"width":691,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac67bf9142da411889c36c686b25d2bc","type":"text","conversion_output":true,"text":"- 20-meter walk test (see Section 7.3.5)","text_display":"\n- 20-meter walk test (see Section 7.3.5)","confidence":0.99755859375,"confidence_rate":0.999945681667699},{"cnt":[[245,1811],[913,1811],[913,1863],[245,1863]],"region":{"top_left_x":244,"top_left_y":1811,"width":670,"height":52},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b303df8f24b24e7db28f74b8e1edbcaf","type":"text","conversion_output":true,"text":"- Target knee MRI (see Section 7.3.1)","text_display":"\n- Target knee MRI (see Section 7.3.1)","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1592,1882],[1592,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1882,"width":1348,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c261d2a74f2b4f718a47463a6125ad5d","type":"text","conversion_output":true,"text":"- Review of inclusion and exclusion criteria (see Sections 5.3.1, 5.3.2, and 5.4)","text_display":"\n- Review of inclusion and exclusion criteria (see Sections 5.3.1, 5.3.2, and 5.4)","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[245,1955],[561,1955],[561,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1955,"width":317,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf65a081c0654a00a51f8fa290e38837","type":"text","conversion_output":true,"text":"- Randomization","text_display":"\n- Randomization","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1882,2041],[1882,2095],[245,2095]],"region":{"top_left_x":244,"top_left_y":2041,"width":1639,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88451af9f21946999d7dfcc84bf75b79","type":"text","conversion_output":true,"text":"Provided that the subject fulfills all inclusion and no exclusion criteria, \\(s / he\\) will be randomized","text_display":"\n\nProvided that the subject fulfills all inclusion and no exclusion criteria, \\(s / he\\) will be randomized","confidence":0.559793229913339,"confidence_rate":0.994878753256731},{"cnt":[[245,2093],[1882,2093],[1882,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2092,"width":1639,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1d1cef0b8814967adee54c682e6c90e","type":"text","conversion_output":true,"text":"to treatment using the IVRS as described in Section 6.3. Medication from the assigned treatment","text_display":" to treatment using the IVRS as described in Section 6.3. Medication from the assigned treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1882,2140],[1882,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2139,"width":1639,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39f22fa463d9499fafd634d803f6c73a","type":"text","conversion_output":true,"text":"kit will be prepared as described in Section 6.2 and administered i.a. according to instructions in","text_display":" kit will be prepared as described in Section 6.2 and administered i.a. according to instructions in","confidence":0.99074625025969,"confidence_rate":0.9999131174972323},{"cnt":[[245,2187],[417,2187],[417,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2187,"width":173,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2473f0e4d0ec4c76a4dd8f1557441a2f","type":"text","conversion_output":true,"text":"the MOP.","text_display":" the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,2260],[1882,2260],[1882,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2260,"width":1639,"height":54},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5533df63d21649a6bb31a49444a31c10","type":"text","conversion_output":true,"text":"- Using aseptic technique, i.a. administration of IMP will be guided by ultrasound to ensure","text_display":"\n- Using aseptic technique, i.a. administration of IMP will be guided by ultrasound to ensure","confidence":1,"confidence_rate":1},{"cnt":[[292,2307],[967,2307],[967,2361],[292,2361]],"region":{"top_left_x":292,"top_left_y":2307,"width":675,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a082b611ca7a4c0ebb20d52274535553","type":"text","conversion_output":true,"text":"delivery of the IMP into the joint space.","text_display":" delivery of the IMP into the joint space.","confidence":1,"confidence_rate":1},{"cnt":[[245,2378],[1882,2378],[1882,2430],[245,2430]],"region":{"top_left_x":244,"top_left_y":2378,"width":1639,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d029f18155f41ca938c3925a27ae3cb","type":"text","conversion_output":true,"text":"- Before injecting the IMP solution, an aspiration of the synovial fluid for PK and biomarker","text_display":"\n- Before injecting the IMP solution, an aspiration of the synovial fluid for PK and biomarker","confidence":1,"confidence_rate":1},{"cnt":[[292,2428],[1882,2428],[1882,2479],[292,2479]],"region":{"top_left_x":292,"top_left_y":2427,"width":1591,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba4e74916854429f806c85e136df0b0e","type":"text","conversion_output":true,"text":"analysis will be performed as part of the i.a. injection procedure, using the same needle that","text_display":" analysis will be performed as part of the i.a. injection procedure, using the same needle that","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":37,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ab37a38a6ce04f0b9790817f047b5b44","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2548],[389,2545],[390,2587],[245,2590]],"region":{"top_left_x":244,"top_left_y":2545,"width":146,"height":45},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c0f4600cd35d4821803ecc445e01fe1f","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fde44ecc607466f823929f87dd925ab","type":"page_info","conversion_output":false,"text":"62/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-063","page":63,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cac0794120f4791ab0904d30193c042","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a709f8f6948e4e8f80c655faadf96753","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7dcb196f925b4e63b32af680219b1f67","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[292,279],[1882,279],[1882,331],[292,331]],"region":{"top_left_x":292,"top_left_y":279,"width":1591,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00719f9fff00409a95b9fdeedaa50dde","type":"text","conversion_output":true,"text":"will be used for IMP injection. If possible, up to 2.5 mL of synovial fluid should be collected","text_display":"\nwill be used for IMP injection. If possible, up to 2.5 mL of synovial fluid should be collected","confidence":0.9985356330871582,"confidence_rate":0.9999860435245741},{"cnt":[[294,329],[1304,329],[1304,380],[294,380]],"region":{"top_left_x":294,"top_left_y":328,"width":1011,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d88483fffa7443848a46aafc9d6c471f","type":"text","conversion_output":true,"text":"(instructions for sample handling are provided in the MOP).","text_display":" (instructions for sample handling are provided in the MOP).","confidence":1,"confidence_rate":1},{"cnt":[[245,421],[1882,421],[1882,475],[245,475]],"region":{"top_left_x":244,"top_left_y":421,"width":1639,"height":54},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1f6e8a8d5934b2daf32a9c2be566fa9","type":"text","conversion_output":true,"text":"If it is not possible to schedule an MRI scan for the same day as the other baseline assessments","text_display":"\n\nIf it is not possible to schedule an MRI scan for the same day as the other baseline assessments","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1882,471],[1882,522],[245,522]],"region":{"top_left_x":244,"top_left_y":470,"width":1639,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22c3b67832d24cc18d2b7b607c68e9d0","type":"text","conversion_output":true,"text":"(including confirmation of eligibility by baseline WOMAC) for logistical reasons, the baseline","text_display":" (including confirmation of eligibility by baseline WOMAC) for logistical reasons, the baseline","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,520],[1880,520],[1880,569],[245,569]],"region":{"top_left_x":244,"top_left_y":519,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc40c93486b44ca3b8d5f51b5b04a23b","type":"text","conversion_output":true,"text":"MRI may be performed up to 3 days after confirmation of eligibility. Randomization and IMP","text_display":" MRI may be performed up to 3 days after confirmation of eligibility. Randomization and IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,567],[1880,567],[1880,621],[245,621]],"region":{"top_left_x":244,"top_left_y":567,"width":1636,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea9e2ce8f4094e5eb5e03c2b00dc9de9","type":"text","conversion_output":true,"text":"administration will then take place on the day of the baseline MRI (following the scan), and","text_display":" administration will then take place on the day of the baseline MRI (following the scan), and","confidence":1,"confidence_rate":1},{"cnt":[[245,614],[1828,614],[1828,668],[245,668]],"region":{"top_left_x":244,"top_left_y":614,"width":1585,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a099b9e5f394c0a80269bba9b688415","type":"text","conversion_output":true,"text":"subsequent visits will be planned relative to the day of randomization and IMP administration.","text_display":" subsequent visits will be planned relative to the day of randomization and IMP administration.","confidence":1,"confidence_rate":1},{"cnt":[[245,705],[1882,705],[1882,754],[245,754]],"region":{"top_left_x":244,"top_left_y":704,"width":1639,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afe451814083454cb72f1530634d5005","type":"text","conversion_output":true,"text":"If confirmation of eligibility and baseline MRI scanning are performed on different days, all","text_display":"\n\nIf confirmation of eligibility and baseline MRI scanning are performed on different days, all","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1880,752],[1880,804],[245,804]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce3e301b906242b59d087d5ddddcce67","type":"text","conversion_output":true,"text":"assessments of symptoms (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, NRS pain","text_display":" assessments of symptoms (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, NRS pain","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[1880,799],[1880,853],[245,853]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d784e3fc149c4d04a4d0999d8c53c15a","type":"text","conversion_output":true,"text":"score in the target and contralateral knee, MOS SF-36, pain in other joints, and ICOAP) must be","text_display":" score in the target and contralateral knee, MOS SF-36, pain in other joints, and ICOAP) must be","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,846],[1880,846],[1880,900],[245,900]],"region":{"top_left_x":244,"top_left_y":846,"width":1636,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a819654a5f54798a8a496af3924575e","type":"text","conversion_output":true,"text":"performed on the day of eligibility confirmation and all safety assessments and laboratory","text_display":" performed on the day of eligibility confirmation and all safety assessments and laboratory","confidence":1,"confidence_rate":1},{"cnt":[[245,898],[1880,898],[1880,947],[245,947]],"region":{"top_left_x":244,"top_left_y":898,"width":1636,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aed9182e9e54410ea25f1960961911b5","type":"text","conversion_output":true,"text":"sampling must be performed on the day of MRI scanning (at appropriate times relative to IMP","text_display":" sampling must be performed on the day of MRI scanning (at appropriate times relative to IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,941],[1880,941],[1880,995],[245,995]],"region":{"top_left_x":244,"top_left_y":941,"width":1636,"height":54},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93db037511de4f4cb6c2791c5a6a5a60","type":"text","conversion_output":true,"text":"administration). Details of the division of procedures between these days are provided in","text_display":" administration). Details of the division of procedures between these days are provided in","confidence":1,"confidence_rate":1},{"cnt":[[245,993],[466,993],[466,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":992,"width":223,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1e69110fad449e2b71d785d0f6cca6f","type":"text","conversion_output":true,"text":"Appendix E.","text_display":" Appendix E.","confidence":1,"confidence_rate":1},{"cnt":[[241,1083],[1036,1083],[1036,1145],[241,1145]],"region":{"top_left_x":240,"top_left_y":1082,"width":796,"height":64},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d60ba5ed8d8d41d883394ccc122afe32","type":"section_header","conversion_output":false,"children_ids":["b0301b83b3884ef18ee5446df4b5e084"],"text":"","text_display":""},{"cnt":[[245,1089],[1029,1089],[1029,1141],[245,1141]],"region":{"top_left_x":244,"top_left_y":1089,"width":786,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0301b83b3884ef18ee5446df4b5e084","type":"text","conversion_output":true,"parent_id":"d60ba5ed8d8d41d883394ccc122afe32","text":"7.1.3.2 IMP Administration","text_display":"\n\n\\subsection*{7.1.3.2 IMP Administration}","confidence":0.99951171875,"confidence_rate":0.9999842452693294},{"cnt":[[245,1182],[1414,1182],[1414,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1181,"width":1170,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b1ae24c745d47fbbe0bff6808601d49","type":"text","conversion_output":true,"text":"Subsequent IMP injections will be given at the following time points:","text_display":"\n\nSubsequent IMP injections will be given at the following time points:","confidence":0.9990234375,"confidence_rate":0.9999867968486782},{"cnt":[[245,1255],[1016,1255],[1016,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1254,"width":773,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a2102925ae64e1184505bf157f8cad3","type":"text","conversion_output":true,"text":"- Cycle 1: Weeks 1 and 2 (Visits 3 and 4)","text_display":"\n- Cycle 1: Weeks 1 and 2 (Visits 3 and 4)","confidence":0.9892578125,"confidence_rate":0.9998036501636842},{"cnt":[[245,1328],[1182,1328],[1182,1381],[245,1381]],"region":{"top_left_x":244,"top_left_y":1327,"width":938,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0534d78791084fb7aa70c9baf22b42a6","type":"text","conversion_output":true,"text":"- Cycle 2: Weeks 26, 27, and 28 (Visits 7, 8, and 9)","text_display":"\n- Cycle 2: Weeks 26, 27, and 28 (Visits 7, 8, and 9)","confidence":0.99951171875,"confidence_rate":0.999991860024828},{"cnt":[[245,1399],[1244,1399],[1244,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1398,"width":1000,"height":57},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f80750c7a0894072b588051547231ace","type":"text","conversion_output":true,"text":"- Cycle 3: Weeks 52, 53, and 54 (Visits 12, 13, and 14)","text_display":"\n- Cycle 3: Weeks 52, 53, and 54 (Visits 12, 13, and 14)","confidence":0.9956073760986328,"confidence_rate":0.9999301246664862},{"cnt":[[245,1470],[1253,1470],[1253,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1469,"width":1009,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58f4b533172d438095585cb5760c170b","type":"text","conversion_output":true,"text":"- Cycle 4: Weeks 78, 79, and 80 (Visits 17, 18, and 19).","text_display":"\n- Cycle 4: Weeks 78, 79, and 80 (Visits 17, 18, and 19).","confidence":0.99951171875,"confidence_rate":0.999992368771335},{"cnt":[[245,1560],[1880,1560],[1880,1613],[245,1613]],"region":{"top_left_x":244,"top_left_y":1559,"width":1636,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b32401c2520e42efa2f01d299b4c69ff","type":"text","conversion_output":true,"text":"At visits where IMP is administered, all procedures should be performed before dosing unless","text_display":"\n\nAt visits where IMP is administered, all procedures should be performed before dosing unless","confidence":1,"confidence_rate":1},{"cnt":[[245,1609],[1882,1609],[1882,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1609,"width":1639,"height":52},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f941fc90607e46ac987813c2b27b255c","type":"text","conversion_output":true,"text":"otherwise specified. Urine pregnancy testing will be conducted in women of childbearing","text_display":" otherwise specified. Urine pregnancy testing will be conducted in women of childbearing","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[786,1659],[786,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1658,"width":543,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"024e3a1cc20f45c0bd16a4f1b31fe0b2","type":"text","conversion_output":true,"text":"potential prior to each injection.","text_display":" potential prior to each injection.","confidence":0.9990234375,"confidence_rate":0.999974948015144},{"cnt":[[245,1745],[1880,1745],[1880,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1744,"width":1636,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"314dc7136039467aaed5b9df80317e36","type":"text","conversion_output":true,"text":"Immediately prior to dosing at each of these visits, the Investigator or delegate will obtain a","text_display":"\n\nImmediately prior to dosing at each of these visits, the Investigator or delegate will obtain a","confidence":1,"confidence_rate":1},{"cnt":[[245,1796],[1880,1796],[1880,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1796,"width":1636,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f43dac21d96426fafee5f4c02805612","type":"text","conversion_output":true,"text":"blinded treatment kit number from the IVRS as described in Section 6.3. Medication from the","text_display":" blinded treatment kit number from the IVRS as described in Section 6.3. Medication from the","confidence":1,"confidence_rate":1},{"cnt":[[245,1841],[1880,1841],[1880,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1841,"width":1636,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1e482ea9157475f8ce981e26225b61b","type":"text","conversion_output":true,"text":"assigned treatment kit will be prepared as described in Section 6.2 and administered i.a.","text_display":" assigned treatment kit will be prepared as described in Section 6.2 and administered i.a.","confidence":1,"confidence_rate":1},{"cnt":[[245,1891],[883,1891],[883,1940],[245,1940]],"region":{"top_left_x":244,"top_left_y":1890,"width":640,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd7f81b3458a492b8ed54f65434b5730","type":"text","conversion_output":true,"text":"according to instructions in the MOP.","text_display":" according to instructions in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,1962],[1884,1962],[1884,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1961,"width":1641,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08ff46f7fe0344ed9e17e3f5c0ce85d0","type":"text","conversion_output":true,"text":"- Using aseptic technique, i.a. administration will be guided by ultrasound to ensure delivery of","text_display":"\n- Using aseptic technique, i.a. administration will be guided by ultrasound to ensure delivery of","confidence":1,"confidence_rate":1},{"cnt":[[292,2011],[776,2011],[776,2060],[292,2060]],"region":{"top_left_x":292,"top_left_y":2010,"width":484,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af631d05fa7a45059ffc26d0555a3eb4","type":"text","conversion_output":true,"text":"the IMP into the joint space.","text_display":" the IMP into the joint space.","confidence":1,"confidence_rate":1},{"cnt":[[245,2082],[1882,2082],[1882,2133],[245,2133]],"region":{"top_left_x":244,"top_left_y":2081,"width":1639,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"989ca19461c74189b873d2fae02eb9b4","type":"text","conversion_output":true,"text":"- Before injecting the IMP solution, an aspiration of the synovial fluid for PK and biomarker","text_display":"\n- Before injecting the IMP solution, an aspiration of the synovial fluid for PK and biomarker","confidence":1,"confidence_rate":1},{"cnt":[[294,2127],[1882,2127],[1882,2181],[294,2181]],"region":{"top_left_x":294,"top_left_y":2126,"width":1589,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce5e25c195cf4dd7b650b58f91dea2f4","type":"text","conversion_output":true,"text":"analysis will be performed as part of the i.a. injection procedure, using the same needle that","text_display":" analysis will be performed as part of the i.a. injection procedure, using the same needle that","confidence":1,"confidence_rate":1},{"cnt":[[292,2179],[1882,2179],[1882,2228],[292,2228]],"region":{"top_left_x":292,"top_left_y":2178,"width":1591,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ca9d94285004f278b6422261dca6ac2","type":"text","conversion_output":true,"text":"will be used for injection. If possible, up to 2.5 mL should be collected (instructions for","text_display":" will be used for injection. If possible, up to 2.5 mL should be collected (instructions for","confidence":1,"confidence_rate":1},{"cnt":[[292,2226],[1027,2226],[1027,2277],[292,2277]],"region":{"top_left_x":292,"top_left_y":2225,"width":735,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"899ee5b134764039bee11ae82d98418c","type":"text","conversion_output":true,"text":"sample handling are provided in the MOP).","text_display":" sample handling are provided in the MOP).","confidence":1,"confidence_rate":1},{"cnt":[[245,2314],[1880,2314],[1880,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2313,"width":1636,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd14c400ae99494fb24105a932bfb0bb","type":"text","conversion_output":true,"text":"At visits where samples are collected for PK analyses (see Appendix E), subjects will be","text_display":"\n\nAt visits where samples are collected for PK analyses (see Appendix E), subjects will be","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,2363],[1882,2363],[1882,2415],[245,2415]],"region":{"top_left_x":244,"top_left_y":2363,"width":1639,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1950ba12a9534a339aca92fdfdf29754","type":"text","conversion_output":true,"text":"requested to stay in the study site for approximately 2 hours post-injection for collection of the","text_display":" requested to stay in the study site for approximately 2 hours post-injection for collection of the","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"aa214ec7ca2b491389d4342fcbbe8c88","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2545],[390,2587],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":146,"height":45},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4bb8457ecd0d47b09bbcf379eac2574b","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.9990234375,"confidence_rate":0.9999348661447799},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6fdabbca1df4926a1092b119873fae6","type":"page_info","conversion_output":false,"text":"63/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-064","page":64,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"788c2ee5de4e4fbdb8eee330a98ff2cb","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1319,125],[1319,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":678,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d939688113b4e41896b3315f35692cd","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[537,168],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":167,"width":294,"height":50},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f017be1d47cf4331aba4d9166a950693","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"976752c7cccb4b98bf84abd9568d898c","type":"text","conversion_output":true,"text":"post-dose samples. At visits where biomarkers are collected, samples will be collected in the","text_display":"\npost-dose samples. At visits where biomarkers are collected, samples will be collected in the","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[466,329],[466,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":223,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24796f83ecb6419c8b9ce1c05869b60c","type":"text","conversion_output":true,"text":"fasting state.","text_display":" fasting state.","confidence":1,"confidence_rate":1},{"cnt":[[236,412],[1886,412],[1886,541],[236,541]],"region":{"top_left_x":236,"top_left_y":412,"width":1651,"height":130},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0aec4fe7f7b4479b59128429d277581","type":"section_header","conversion_output":false,"children_ids":["c437961d6ed54ae3bf4df2d148cff414","8de1611e46e3443a99272fcd5b1a39d2"],"text":"","text_display":""},{"cnt":[[243,417],[1882,417],[1882,479],[243,479]],"region":{"top_left_x":242,"top_left_y":416,"width":1641,"height":64},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c437961d6ed54ae3bf4df2d148cff414","type":"text","conversion_output":true,"parent_id":"f0aec4fe7f7b4479b59128429d277581","text":"7.1.3.3 Major Efficacy Visits (Weeks 26, 52, 78, and 104; Visits 7, 12,","text_display":"\n\n\\subsection*{7.1.3.3 Major Efficacy Visits (Weeks 26, 52, 78, and 104; Visits 7, 12,","confidence":1,"confidence_rate":1},{"cnt":[[593,477],[836,477],[836,535],[593,535]],"region":{"top_left_x":592,"top_left_y":476,"width":244,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8de1611e46e3443a99272fcd5b1a39d2","type":"text","conversion_output":true,"parent_id":"f0aec4fe7f7b4479b59128429d277581","text":"17, and 22)","text_display":" 17, and 22)}","confidence":0.99951171875,"confidence_rate":0.9999694754347522},{"cnt":[[243,569],[1882,569],[1882,623],[243,623]],"region":{"top_left_x":242,"top_left_y":569,"width":1641,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5da78c58d33c460abb7375d7d566d71d","type":"text","conversion_output":true,"text":"Major efficacy visits will take place at intervals of 6 months (on the first day of each treatment","text_display":"\n\nMajor efficacy visits will take place at intervals of 6 months (on the first day of each treatment","confidence":0.9956090442137793,"confidence_rate":0.9999584855377324},{"cnt":[[243,619],[1543,619],[1543,672],[243,672]],"region":{"top_left_x":242,"top_left_y":618,"width":1301,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4211ff7078d4f428f3a47e6280984a8","type":"text","conversion_output":true,"text":"cycle) and then at the end of the DBPC treatment phase (Week 104/Visit 22).","text_display":" cycle) and then at the end of the DBPC treatment phase (Week 104/Visit 22).","confidence":0.998046875,"confidence_rate":0.9999755623631563},{"cnt":[[243,709],[1880,709],[1880,761],[243,761]],"region":{"top_left_x":242,"top_left_y":708,"width":1638,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2708d50a2b64c8f9573a45955bc916d","type":"text","conversion_output":true,"text":"The following procedures will be performed at major efficacy visits. At visits where IMP is","text_display":"\n\nThe following procedures will be performed at major efficacy visits. At visits where IMP is","confidence":1,"confidence_rate":1},{"cnt":[[245,756],[1880,756],[1880,810],[245,810]],"region":{"top_left_x":244,"top_left_y":756,"width":1636,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61229569d81044d38231dd941dff318d","type":"text","conversion_output":true,"text":"administered, all procedures should be performed before dosing unless otherwise specified.","text_display":" administered, all procedures should be performed before dosing unless otherwise specified.","confidence":1,"confidence_rate":1},{"cnt":[[245,804],[1880,804],[1880,857],[245,857]],"region":{"top_left_x":244,"top_left_y":803,"width":1636,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8926d21f1e540a0b711fdfadb2baebe","type":"text","conversion_output":true,"text":"Subject questionnaires (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain","text_display":" Subject questionnaires (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain","confidence":1,"confidence_rate":1},{"cnt":[[245,853],[1880,853],[1880,904],[245,904]],"region":{"top_left_x":244,"top_left_y":852,"width":1636,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5361273cc80e4fca8f3e8f6e67c71205","type":"text","conversion_output":true,"text":"score in the target and contralateral knee, MOS SF-36, pain in other joints, and ICOAP) should","text_display":" score in the target and contralateral knee, MOS SF-36, pain in other joints, and ICOAP) should","confidence":1,"confidence_rate":1},{"cnt":[[245,900],[1880,900],[1880,952],[245,952]],"region":{"top_left_x":244,"top_left_y":900,"width":1636,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5af9f2ff16884855971dc8b8f9f6d6a3","type":"text","conversion_output":true,"text":"be completed before any other procedures are performed; the WOMAC should be completed","text_display":" be completed before any other procedures are performed; the WOMAC should be completed","confidence":1,"confidence_rate":1},{"cnt":[[245,950],[333,950],[333,995],[245,995]],"region":{"top_left_x":244,"top_left_y":949,"width":90,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"894c2cb5fa574b6dab70f1f1304be2ed","type":"text","conversion_output":true,"text":"first.","text_display":" first.","confidence":1,"confidence_rate":1},{"cnt":[[245,1018],[771,1018],[771,1072],[245,1072]],"region":{"top_left_x":244,"top_left_y":1018,"width":528,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b48affc11f44d48b0c79fe96f8a454a","type":"text","conversion_output":true,"text":"- WOMAC (see Appendix C)","text_display":"\n- WOMAC (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[707,1091],[707,1143],[245,1143]],"region":{"top_left_x":244,"top_left_y":1091,"width":463,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50001a215c4f47e78505d5d34f2e173c","type":"text","conversion_output":true,"text":"- PGA (see Section 7.3.3)","text_display":"\n- PGA (see Section 7.3.3)","confidence":1,"confidence_rate":1},{"cnt":[[245,1164],[819,1164],[819,1216],[245,1216]],"region":{"top_left_x":244,"top_left_y":1164,"width":575,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d04d3d41100249ebbb6f419789724ea3","type":"text","conversion_output":true,"text":"- KOOS QOL (see Appendix D)","text_display":"\n- KOOS QOL (see Appendix D)","confidence":1,"confidence_rate":1},{"cnt":[[245,1238],[999,1238],[999,1287],[245,1287]],"region":{"top_left_x":244,"top_left_y":1237,"width":756,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64d2f0123eba41b1bb8d1c5245eff966","type":"text","conversion_output":true,"text":"- KOOS Symptom Index (see Appendix D)","text_display":"\n- KOOS Symptom Index (see Appendix D)","confidence":0.99951171875,"confidence_rate":0.9999883714843234},{"cnt":[[245,1306],[720,1306],[720,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1306,"width":476,"height":54},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"270f3230c71d40548f5a971b6fb3ab08","type":"text","conversion_output":true,"text":"- PGIC (see Section 7.7.4)","text_display":"\n- PGIC (see Section 7.7.4)","confidence":1,"confidence_rate":1},{"cnt":[[245,1379],[786,1379],[786,1431],[245,1431]],"region":{"top_left_x":244,"top_left_y":1379,"width":543,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"521d7684f9624103b92abdf449cc5e24","type":"text","conversion_output":true,"text":"- NRS pain (see Section 7.7.5)","text_display":"\n- NRS pain (see Section 7.7.5)","confidence":1,"confidence_rate":1},{"cnt":[[245,1450],[917,1450],[917,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1450,"width":674,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6aa585d98c8547ef975dafa80275ec04","type":"text","conversion_output":true,"text":"- Pain in other joints (see Appendix F)","text_display":"\n- Pain in other joints (see Appendix F)","confidence":1,"confidence_rate":1},{"cnt":[[245,1521],[810,1521],[810,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1521,"width":566,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e11c601b513e4f0b83dabd295daef99d","type":"text","conversion_output":true,"text":"- MOS SF-36 (see Appendix C)","text_display":"\n- MOS SF-36 (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[733,1594],[733,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1594,"width":489,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77612bdbb9d94b95a7b5be1a7d7f3920","type":"text","conversion_output":true,"text":"- ICOAP (see Appendix C)","text_display":"\n- ICOAP (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[1880,1667],[1880,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1667,"width":1636,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"958ba961e16c44c7b9bd5249711a64aa","type":"text","conversion_output":true,"text":"- Review of AEs, concomitant medications, and concomitant procedures on the target knee (see","text_display":"\n- Review of AEs, concomitant medications, and concomitant procedures on the target knee (see","confidence":1,"confidence_rate":1},{"cnt":[[294,1714],[685,1714],[685,1764],[294,1764]],"region":{"top_left_x":294,"top_left_y":1714,"width":392,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c8e6729a0c54b2097ea4d46880341d9","type":"text","conversion_output":true,"text":"Sections 7.4.1 and 6.5)","text_display":" Sections 7.4.1 and 6.5)","confidence":1,"confidence_rate":1},{"cnt":[[245,1783],[1044,1783],[1044,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1783,"width":801,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff8ef57200f24de191368839aec4dabf","type":"text","conversion_output":true,"text":"- Review of subject diaries (see Section 7.1.1)","text_display":"\n- Review of subject diaries (see Section 7.1.1)","confidence":1,"confidence_rate":1},{"cnt":[[245,1856],[1046,1856],[1046,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1856,"width":803,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ea156681d4142859327960a436066b0","type":"text","conversion_output":true,"text":"- Vital signs measurement (see Section 7.4.4),","text_display":"\n- Vital signs measurement (see Section 7.4.4),","confidence":1,"confidence_rate":1},{"cnt":[[245,1929],[1669,1929],[1669,1981],[245,1981]],"region":{"top_left_x":244,"top_left_y":1929,"width":1426,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d008bfe8d5f04432b2d8cb3f6e658c44","type":"text","conversion_output":true,"text":"- Physical examination including weight measurement (and height at Visit 22 only)","text_display":"\n- Physical examination including weight measurement (and height at Visit 22 only)","confidence":1,"confidence_rate":1},{"cnt":[[245,1998],[1880,1998],[1880,2052],[245,2052]],"region":{"top_left_x":244,"top_left_y":1998,"width":1636,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fec918d314344da18fffb131ceaa5ea5","type":"text","conversion_output":true,"text":"- Sample collection for hematology, biochemistry, and urinalysis (see Section 7.4.3 and","text_display":"\n- Sample collection for hematology, biochemistry, and urinalysis (see Section 7.4.3 and","confidence":1,"confidence_rate":1},{"cnt":[[292,2050],[518,2050],[518,2099],[292,2099]],"region":{"top_left_x":292,"top_left_y":2049,"width":226,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"871c0ec16dc7449fb70df07a57280178","type":"text","conversion_output":true,"text":"Appendix B)","text_display":" Appendix B)","confidence":1,"confidence_rate":1},{"cnt":[[245,2118],[1691,2118],[1691,2172],[245,2172]],"region":{"top_left_x":244,"top_left_y":2118,"width":1447,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8b3a491739d45c08e65de5b3d4c11fb","type":"text","conversion_output":true,"text":"- Blood collection for testing for antibodies to sprifermin/FGF-18 (see Section 7.4.3)","text_display":"\n- Blood collection for testing for antibodies to sprifermin/FGF-18 (see Section 7.4.3)","confidence":1,"confidence_rate":1},{"cnt":[[245,2191],[1265,2191],[1265,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2191,"width":1022,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b70e3cee06ec4b77a3b1c9df8bb6568f","type":"text","conversion_output":true,"text":"- Urine pregnancy test for women of childbearing potential","text_display":"\n- Urine pregnancy test for women of childbearing potential","confidence":1,"confidence_rate":1},{"cnt":[[245,2264],[935,2264],[935,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2264,"width":691,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d052e9027d4043ed9bc4f9892936c47c","type":"text","conversion_output":true,"text":"- 20-meter walk test (see Section 7.3.5)","text_display":"\n- 20-meter walk test (see Section 7.3.5)","confidence":0.9833984375,"confidence_rate":0.9996280489047242},{"cnt":[[245,2333],[913,2333],[913,2387],[245,2387]],"region":{"top_left_x":244,"top_left_y":2333,"width":670,"height":54},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64d5bbed0e2848b1b33ea750b0e1ac13","type":"text","conversion_output":true,"text":"- Target knee MRI (see Section 7.3.1)","text_display":"\n- Target knee MRI (see Section 7.3.1)","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e6ad94c42f54ef68c935c4e1bd04ec1","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2545],[389,2543],[390,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2542,"width":146,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebc1029dcbef484db2a10a08e53cc5e4","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2529],[1601,2529],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2528,"width":93,"height":36},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d8f0ec3f83643709c52718649e3f90d","type":"page_info","conversion_output":false,"text":"64/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-065","page":65,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec956593555c42e6becff03d6246227a","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"711d60cd9d3343eab443615eda082b8e","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c83fe937eb345119dab0e6fc4f0d312","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,281],[1882,281],[1882,333],[245,333]],"region":{"top_left_x":244,"top_left_y":281,"width":1639,"height":53},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"967222c23ab54fe49fd86d4968c3a760","type":"text","conversion_output":true,"text":"- Knee X-ray (Weeks 52 and 104/Visits 12 and 22 only; see Section 7.3.4). An X-ray of the","text_display":"\n- Knee X-ray (Weeks 52 and 104/Visits 12 and 22 only; see Section 7.3.4). An X-ray of the","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[292,331],[1201,331],[1201,380],[292,380]],"region":{"top_left_x":292,"top_left_y":330,"width":909,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99eebebdce8a4bee963902be1a8e9f24","type":"text","conversion_output":true,"text":"contralateral knee will be taken at Week 104/Visit 22.","text_display":" contralateral knee will be taken at Week 104/Visit 22.","confidence":1,"confidence_rate":1},{"cnt":[[245,421],[1880,421],[1880,473],[245,473]],"region":{"top_left_x":244,"top_left_y":421,"width":1636,"height":52},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52c5c7dd27c04573b0820a90beb17a3e","type":"text","conversion_output":true,"text":"IMP dosing and synovial fluid collection will take place at the following major efficacy visits:","text_display":"\n\nIMP dosing and synovial fluid collection will take place at the following major efficacy visits:","confidence":1,"confidence_rate":1},{"cnt":[[245,468],[1313,468],[1313,522],[245,522]],"region":{"top_left_x":244,"top_left_y":468,"width":1069,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2efb9fb092441d0ba05b76de0bd5a1f","type":"text","conversion_output":true,"text":"Weeks 26, 52, and 78/Visits 7, 12, and 17 (see Section 7.1.3.2).","text_display":" Weeks 26, 52, and 78/Visits 7, 12, and 17 (see Section 7.1.3.2).","confidence":0.9833984375,"confidence_rate":0.9997675143500767},{"cnt":[[245,559],[1880,559],[1880,617],[245,617]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b747c6abde0b49d9b8668d3573647d18","type":"text","conversion_output":true,"text":"7.1.3.4 Minor Efficacy Visits (Weeks 12, 38, 64, and 90; Visits 6, 11,","text_display":"\n7.1.3.4 Minor Efficacy Visits (Weeks 12, 38, 64, and 90; Visits 6, 11,","confidence":1,"confidence_rate":1},{"cnt":[[593,614],[831,614],[831,672],[593,672]],"region":{"top_left_x":592,"top_left_y":614,"width":240,"height":59},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10030c06581c403d8b78ea5d7666d1bf","type":"text","conversion_output":true,"text":"16, and 21)","text_display":" 16, and 21)","confidence":0.99853515625,"confidence_rate":0.9999083843418147},{"cnt":[[245,711],[1886,711],[1886,763],[245,763]],"region":{"top_left_x":244,"top_left_y":711,"width":1643,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e4c53aff8124d82883e969538ecdbee","type":"text","conversion_output":true,"text":"Minor efficacy visits will take place at intervals of 6 months ( 12 weeks after the beginning of","text_display":"\n\nMinor efficacy visits will take place at intervals of 6 months ( 12 weeks after the beginning of","confidence":0.986362189993315,"confidence_rate":0.9998716749710039},{"cnt":[[245,761],[621,761],[621,810],[245,810]],"region":{"top_left_x":244,"top_left_y":760,"width":377,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71131f472d784aa9a5b8126ec748f554","type":"text","conversion_output":true,"text":"each treatment cycle).","text_display":" each treatment cycle).","confidence":1,"confidence_rate":1},{"cnt":[[245,849],[1880,849],[1880,900],[245,900]],"region":{"top_left_x":244,"top_left_y":848,"width":1636,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6eb829e14eb54f558acefc8b77c31f89","type":"text","conversion_output":true,"text":"The following procedures will be performed at these visits. Subject questionnaires (WOMAC,","text_display":"\n\nThe following procedures will be performed at these visits. Subject questionnaires (WOMAC,","confidence":1,"confidence_rate":1},{"cnt":[[245,898],[1880,898],[1880,947],[245,947]],"region":{"top_left_x":244,"top_left_y":898,"width":1636,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"faf6fd7045a540af877596101b746b99","type":"text","conversion_output":true,"text":"PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain score in the target and contralateral","text_display":" PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain score in the target and contralateral","confidence":1,"confidence_rate":1},{"cnt":[[245,945],[1652,945],[1652,999],[245,999]],"region":{"top_left_x":244,"top_left_y":945,"width":1409,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0faa2abdcc8d48d2bf2b535f6db74647","type":"text","conversion_output":true,"text":"knee, and ICOAP) should be completed before any other procedures are performed.","text_display":" knee, and ICOAP) should be completed before any other procedures are performed.","confidence":1,"confidence_rate":1},{"cnt":[[245,1016],[776,1016],[776,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1016,"width":532,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de06dd28413a462e920034fe15be7d28","type":"text","conversion_output":true,"text":"- WOMAC (see Appendix C)","text_display":"\n- WOMAC (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[707,1087],[707,1141],[245,1141]],"region":{"top_left_x":244,"top_left_y":1087,"width":463,"height":54},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07c8222433114b36ac8a9fbd450c5818","type":"text","conversion_output":true,"text":"- PGA (see Section 7.3.3)","text_display":"\n- PGA (see Section 7.3.3)","confidence":1,"confidence_rate":1},{"cnt":[[245,1160],[821,1160],[821,1214],[245,1214]],"region":{"top_left_x":244,"top_left_y":1160,"width":577,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d64a72abf984a318dfbc7d68d830e16","type":"text","conversion_output":true,"text":"- KOOS QOL (see Appendix D)","text_display":"\n- KOOS QOL (see Appendix D)","confidence":1,"confidence_rate":1},{"cnt":[[245,1283],[245,1231],[1001,1233],[1001,1285]],"region":{"top_left_x":244,"top_left_y":1230,"width":758,"height":56},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90aa3e3a323149ff8328f7525e03d9df","type":"text","conversion_output":true,"text":"- KOOS Symptom Index (see Appendix D)","text_display":"\n- KOOS Symptom Index (see Appendix D)","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[720,1302],[720,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1301,"width":476,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b20d38798ba4d12b0153f5c46e5941b","type":"text","conversion_output":true,"text":"- PGIC (see Section 7.7.4)","text_display":"\n- PGIC (see Section 7.7.4)","confidence":1,"confidence_rate":1},{"cnt":[[245,1375],[788,1375],[788,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1375,"width":545,"height":54},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5bdedfcfcc64d89aef66f3c18af5c9f","type":"text","conversion_output":true,"text":"- NRS pain (see Section 7.7.5)","text_display":"\n- NRS pain (see Section 7.7.5)","confidence":1,"confidence_rate":1},{"cnt":[[245,1448],[733,1448],[733,1500],[245,1500]],"region":{"top_left_x":244,"top_left_y":1448,"width":489,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43698f9ed6f94a23aa2580f765d37cda","type":"text","conversion_output":true,"text":"- ICOAP (see Appendix C)","text_display":"\n- ICOAP (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,1519],[1882,1519],[1882,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1518,"width":1639,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"484ad5a8e6714e4082b401e107c1da0b","type":"text","conversion_output":true,"text":"- Review of AEs, concomitant medications, and concomitant procedures on the target knee (see","text_display":"\n- Review of AEs, concomitant medications, and concomitant procedures on the target knee (see","confidence":1,"confidence_rate":1},{"cnt":[[294,1568],[685,1568],[685,1618],[294,1618]],"region":{"top_left_x":294,"top_left_y":1568,"width":392,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87867282243d4c88aff4a3c54582ac29","type":"text","conversion_output":true,"text":"Sections 7.4.1 and 6.5)","text_display":" Sections 7.4.1 and 6.5)","confidence":1,"confidence_rate":1},{"cnt":[[245,1639],[1046,1639],[1046,1691],[245,1691]],"region":{"top_left_x":244,"top_left_y":1639,"width":803,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd59165521ec4c5f9c53935481baf588","type":"text","conversion_output":true,"text":"- Review of subject diaries (see Section 7.1.1)","text_display":"\n- Review of subject diaries (see Section 7.1.1)","confidence":1,"confidence_rate":1},{"cnt":[[245,1710],[1033,1710],[1033,1762],[245,1762]],"region":{"top_left_x":244,"top_left_y":1710,"width":790,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42025b63a7b946e987fcfe520f36ead5","type":"text","conversion_output":true,"text":"- Vital signs measurement (see Section 7.4.4)","text_display":"\n- Vital signs measurement (see Section 7.4.4)","confidence":0.9990234375,"confidence_rate":0.9999804593979635},{"cnt":[[245,1783],[662,1783],[662,1833],[245,1833]],"region":{"top_left_x":244,"top_left_y":1783,"width":418,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d3df8b9ccfe447a8bdc30c0c32ebd3b","type":"text","conversion_output":true,"text":"- Physical examination","text_display":"\n- Physical examination","confidence":1,"confidence_rate":1},{"cnt":[[245,1852],[935,1852],[935,1906],[245,1906]],"region":{"top_left_x":244,"top_left_y":1851,"width":691,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e360948e9d4478a9306ba9fc4520a8e","type":"text","conversion_output":true,"text":"- 20-meter walk test (see Section 7.3.5)","text_display":"\n- 20-meter walk test (see Section 7.3.5)","confidence":0.99853515625,"confidence_rate":0.9999674245820905},{"cnt":[[243,1942],[1171,1942],[1171,2009],[243,2009]],"region":{"top_left_x":242,"top_left_y":1942,"width":929,"height":67},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf8cb29c1ae14c3fb0034ec3846c4efe","type":"section_header","conversion_output":false,"children_ids":["54907f6481b9436e969b54e6aec2d6dd"],"text":"","text_display":""},{"cnt":[[245,1946],[1167,1946],[1167,2004],[245,2004]],"region":{"top_left_x":244,"top_left_y":1946,"width":923,"height":59},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54907f6481b9436e969b54e6aec2d6dd","type":"text","conversion_output":true,"parent_id":"bf8cb29c1ae14c3fb0034ec3846c4efe","text":"7.1.4 Extended Follow-Up Phase","text_display":"\n\n\\subsection*{7.1.4 Extended Follow-Up Phase}","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1880,2041],[1880,2090],[245,2090]],"region":{"top_left_x":244,"top_left_y":2041,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c85eab50422b4b5d92ffed5e97bbda17","type":"text","conversion_output":true,"text":"Visits during the 3 -year extended follow-up phase will take place at 6 -month intervals (see","text_display":"\n\nVisits during the 3 -year extended follow-up phase will take place at 6 -month intervals (see","confidence":0.92724609375,"confidence_rate":0.9992739533596324},{"cnt":[[245,2088],[1880,2088],[1880,2140],[245,2140]],"region":{"top_left_x":244,"top_left_y":2088,"width":1636,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d4d7d2da21343779221c9ae04e77712","type":"text","conversion_output":true,"text":"Appendix E). Subjects will be requested to discontinue the intake of all pain medications for 5","text_display":" Appendix E). Subjects will be requested to discontinue the intake of all pain medications for 5","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[1880,2136],[1880,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2135,"width":1636,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87ae62372e394c6da4a2b87213dd5ff5","type":"text","conversion_output":true,"text":"half-lives before each extended follow-up visit. At least 3 days before each visit, site staff will","text_display":" half-lives before each extended follow-up visit. At least 3 days before each visit, site staff will","confidence":1,"confidence_rate":1},{"cnt":[[245,2185],[1287,2185],[1287,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2184,"width":1043,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22284d84f26542b0ad92e90045e6d09b","type":"text","conversion_output":true,"text":"contact subjects by phone to remind them of this requirement.","text_display":" contact subjects by phone to remind them of this requirement.","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1882,2273],[1882,2327],[245,2327]],"region":{"top_left_x":244,"top_left_y":2273,"width":1639,"height":54},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f6aaf26fc2b4bfeb57d193306d34955","type":"text","conversion_output":true,"text":"The following procedures will be performed at all extended follow-up visits. Subject","text_display":"\n\nThe following procedures will be performed at all extended follow-up visits. Subject","confidence":1,"confidence_rate":1},{"cnt":[[245,2322],[1880,2322],[1880,2374],[245,2374]],"region":{"top_left_x":244,"top_left_y":2322,"width":1636,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cccd25a06b5140f9af75eafecd81a2ec","type":"text","conversion_output":true,"text":"questionnaires (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain score in","text_display":" questionnaires (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS pain score in","confidence":1,"confidence_rate":1},{"cnt":[[245,2372],[1880,2372],[1880,2421],[245,2421]],"region":{"top_left_x":244,"top_left_y":2371,"width":1636,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c89e915c96f547a3be2ced8d1bbc0e1b","type":"text","conversion_output":true,"text":"the target and contralateral knee, pain in other joints, and ICOAP) should be completed before","text_display":" the target and contralateral knee, pain in other joints, and ICOAP) should be completed before","confidence":1,"confidence_rate":1},{"cnt":[[245,2419],[1540,2419],[1540,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2419,"width":1297,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26d42ffc17e041e2b106a5bb46a08e83","type":"text","conversion_output":true,"text":"any other procedures are performed; the WOMAC should be completed first.","text_display":" any other procedures are performed; the WOMAC should be completed first.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e7e33e0dcbb34929b4baad33e6056f3d","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2548],[389,2545],[390,2587],[245,2590]],"region":{"top_left_x":244,"top_left_y":2545,"width":146,"height":46},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4962b899c39f49b0803a67a94addee5f","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa92047fb8cc4a918ee49f533a9cbba8","type":"page_info","conversion_output":false,"text":"65/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-066","page":66,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9db3f276697e4dcba2e2d2365df11bbe","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d86164720dc40f196e7252bcac47f2f","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3247be420474c98a946e24d87f2970f","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,281],[776,281],[776,335],[245,335]],"region":{"top_left_x":244,"top_left_y":281,"width":532,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68df017186354729a651caf2c167ee92","type":"text","conversion_output":true,"text":"- WOMAC (see Appendix C)","text_display":"\n- WOMAC (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,357],[707,357],[707,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":463,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"936e0a44150a4f5899f15a1c45d80051","type":"text","conversion_output":true,"text":"- PGA (see Section 7.3.3)","text_display":"\n- PGA (see Section 7.3.3)","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[821,425],[821,479],[245,479]],"region":{"top_left_x":244,"top_left_y":425,"width":577,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e84428a81fae429085685eea83cdf62c","type":"text","conversion_output":true,"text":"- KOOS QOL (see Appendix D)","text_display":"\n- KOOS QOL (see Appendix D)","confidence":1,"confidence_rate":1},{"cnt":[[245,498],[696,498],[696,552],[245,552]],"region":{"top_left_x":244,"top_left_y":498,"width":453,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af78eb72f1494e978edbd024280495e3","type":"text","conversion_output":true,"text":"- KOOS Symptom Index","text_display":"\n- KOOS Symptom Index","confidence":1,"confidence_rate":1},{"cnt":[[245,571],[720,571],[720,621],[245,621]],"region":{"top_left_x":244,"top_left_y":571,"width":476,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c43adcf87d742ca8168671d1b855c1e","type":"text","conversion_output":true,"text":"- PGIC (see Section 7.7.4)","text_display":"\n- PGIC (see Section 7.7.4)","confidence":1,"confidence_rate":1},{"cnt":[[245,640],[788,640],[788,694],[245,694]],"region":{"top_left_x":244,"top_left_y":640,"width":545,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb1b41496b9c484d988ec9dbdd96bcc0","type":"text","conversion_output":true,"text":"- NRS pain (see Section 7.7.5)","text_display":"\n- NRS pain (see Section 7.7.5)","confidence":1,"confidence_rate":1},{"cnt":[[245,713],[920,713],[920,767],[245,767]],"region":{"top_left_x":244,"top_left_y":713,"width":676,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"391a7bfa31474bf296487b76dc26e319","type":"text","conversion_output":true,"text":"- Pain in other joints (see Appendix F)","text_display":"\n- Pain in other joints (see Appendix F)","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[810,786],[810,838],[245,838]],"region":{"top_left_x":244,"top_left_y":786,"width":566,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac8f6fa7a5c548ac9bc4843ec78e89fa","type":"text","conversion_output":true,"text":"- MOS SF-36 (see Appendix C)","text_display":"\n- MOS SF-36 (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,859],[733,859],[733,909],[245,909]],"region":{"top_left_x":244,"top_left_y":859,"width":489,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"125c90ef904d4bd5832e1bf18b8fc8e7","type":"text","conversion_output":true,"text":"- ICOAP (see Appendix C)","text_display":"\n- ICOAP (see Appendix C)","confidence":1,"confidence_rate":1},{"cnt":[[245,928],[1880,928],[1880,982],[245,982]],"region":{"top_left_x":244,"top_left_y":928,"width":1636,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1e5025fd5a740ad959ae0ff3aa6a900","type":"text","conversion_output":true,"text":"- Review of AEs, concomitant medications, and concomitant procedures on the target knee (see","text_display":"\n- Review of AEs, concomitant medications, and concomitant procedures on the target knee (see","confidence":1,"confidence_rate":1},{"cnt":[[294,975],[685,975],[685,1027],[294,1027]],"region":{"top_left_x":294,"top_left_y":975,"width":392,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b079acd054a444d6907e105e4fda90a3","type":"text","conversion_output":true,"text":"Sections 7.4.1 and 6.5)","text_display":" Sections 7.4.1 and 6.5)","confidence":1,"confidence_rate":1},{"cnt":[[245,1048],[1046,1048],[1046,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1048,"width":803,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ccf8c657ac6498e98094adebe9eafc4","type":"text","conversion_output":true,"text":"- Review of subject diaries (see Section 7.1.1)","text_display":"\n- Review of subject diaries (see Section 7.1.1)","confidence":1,"confidence_rate":1},{"cnt":[[245,1121],[1036,1121],[1036,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1121,"width":792,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b68cbbc99ff7416cbf3fe833c0a6ade4","type":"text","conversion_output":true,"text":"- Vital signs measurement (see Section 7.4.4)","text_display":"\n- Vital signs measurement (see Section 7.4.4)","confidence":1,"confidence_rate":1},{"cnt":[[245,1192],[1188,1192],[1188,1244],[245,1244]],"region":{"top_left_x":244,"top_left_y":1192,"width":945,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdc6dba6948e4027871a2cf371fcf206","type":"text","conversion_output":true,"text":"- Physical examination including weight measurement","text_display":"\n- Physical examination including weight measurement","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1880,1263],[1880,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1263,"width":1636,"height":54},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e89e62d41c804560b4f2078a41f742d5","type":"text","conversion_output":true,"text":"- Sample collection for hematology, biochemistry, and urinalysis (see Section 7.4.3 and","text_display":"\n- Sample collection for hematology, biochemistry, and urinalysis (see Section 7.4.3 and","confidence":1,"confidence_rate":1},{"cnt":[[292,1315],[518,1315],[518,1364],[292,1364]],"region":{"top_left_x":292,"top_left_y":1314,"width":226,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e45619d378c84da2873041f2072e7526","type":"text","conversion_output":true,"text":"Appendix B)","text_display":" Appendix B)","confidence":1,"confidence_rate":1},{"cnt":[[245,1384],[935,1384],[935,1435],[245,1435]],"region":{"top_left_x":244,"top_left_y":1383,"width":691,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7543ce79479440e28e6f7ed8fa4da206","type":"text","conversion_output":true,"text":"- 20 -meter walk test (see Section 7.3.5)","text_display":"\n- 20 -meter walk test (see Section 7.3.5)","confidence":0.51171875,"confidence_rate":0.9864199880522745},{"cnt":[[245,1474],[1880,1474],[1880,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1473,"width":1636,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0c67ab05ab14c168dd2d056d5000aca","type":"text","conversion_output":true,"text":"The following additional procedures will be performed at Extended Follow-up Visits 2, 4, and 6","text_display":"\n\nThe following additional procedures will be performed at Extended Follow-up Visits 2, 4, and 6","confidence":1,"confidence_rate":1},{"cnt":[[245,1521],[1463,1521],[1463,1573],[245,1573]],"region":{"top_left_x":244,"top_left_y":1521,"width":1220,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c7fc893746943f6b83db7fad324e90e","type":"text","conversion_output":true,"text":"(Weeks 156, 208, and 260/Visits 24, 26, and 28; i.e., at yearly intervals):","text_display":" (Weeks 156, 208, and 260/Visits 24, 26, and 28; i.e., at yearly intervals):","confidence":0.9951240993104875,"confidence_rate":0.9999389040329885},{"cnt":[[245,1594],[1876,1594],[1876,1646],[245,1646]],"region":{"top_left_x":244,"top_left_y":1594,"width":1632,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55823f5c15fc4b9d8e479666a9287a2e","type":"text","conversion_output":true,"text":"- Urine pregnancy test for women of childbearing potential (before performing X-ray and MRI)","text_display":"\n- Urine pregnancy test for women of childbearing potential (before performing X-ray and MRI)","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[913,1667],[913,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1667,"width":670,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"368b59a6fcef4c5180afc9e11f40e826","type":"text","conversion_output":true,"text":"- Target knee MRI (see Section 7.3.1)","text_display":"\n- Target knee MRI (see Section 7.3.1)","confidence":1,"confidence_rate":1},{"cnt":[[245,1736],[1880,1736],[1880,1785],[245,1785]],"region":{"top_left_x":244,"top_left_y":1735,"width":1636,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"061dc1b1d8124680889aed59321a4c4c","type":"text","conversion_output":true,"text":"- Knee X-ray (see Section 7.3.4). An X-ray of the contralateral knee will be taken at the final","text_display":"\n- Knee X-ray (see Section 7.3.4). An X-ray of the contralateral knee will be taken at the final","confidence":1,"confidence_rate":1},{"cnt":[[294,1783],[720,1783],[720,1835],[294,1835]],"region":{"top_left_x":294,"top_left_y":1783,"width":426,"height":52},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffd5b626183144b9862d715e3c4ba539","type":"text","conversion_output":true,"text":"extended follow-up visit.","text_display":" extended follow-up visit.","confidence":1,"confidence_rate":1},{"cnt":[[245,1856],[1330,1856],[1330,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1856,"width":1086,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b74e7adb87e84e6684227e81a139e75a","type":"text","conversion_output":true,"text":"- Height will be measured at the final extended follow-up visit.","text_display":"\n- Height will be measured at the final extended follow-up visit.","confidence":1,"confidence_rate":1},{"cnt":[[245,1946],[1880,1946],[1880,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1946,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d06d64c6982049f0907f635339fe759a","type":"text","conversion_output":true,"text":"At each visit (with the exception of the final extended follow-up visit), subjects will be given","text_display":"\n\nAt each visit (with the exception of the final extended follow-up visit), subjects will be given","confidence":1,"confidence_rate":1},{"cnt":[[243,1994],[1880,1994],[1880,2043],[243,2043]],"region":{"top_left_x":242,"top_left_y":1993,"width":1638,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cd60a6dc52b48bf948190557873a751","type":"text","conversion_output":true,"text":"trial diaries for recording of any AEs occurring or concomitant medications used between visits","text_display":" trial diaries for recording of any AEs occurring or concomitant medications used between visits","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1592,2041],[1592,2093],[245,2093]],"region":{"top_left_x":244,"top_left_y":2041,"width":1348,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5f47c51fef342d3b310853f511ab26f","type":"text","conversion_output":true,"text":"(see Section 7.1.1). Diaries will be collected and reviewed at the following visit.","text_display":" (see Section 7.1.1). Diaries will be collected and reviewed at the following visit.","confidence":0.998046875,"confidence_rate":0.9999777839418279},{"cnt":[[241,2131],[1446,2131],[1446,2194],[241,2194]],"region":{"top_left_x":240,"top_left_y":2131,"width":1206,"height":63},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b785d21ef8984d539fe472cb95ed2652","type":"section_header","conversion_output":false,"children_ids":["66b3a51a7d104177ae138c049ca94b1a"],"text":"","text_display":""},{"cnt":[[245,2136],[1446,2136],[1446,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2135,"width":1202,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66b3a51a7d104177ae138c049ca94b1a","type":"text","conversion_output":true,"parent_id":"b785d21ef8984d539fe472cb95ed2652","text":"7.1.5 Follow-Up in Case of Early Termination","text_display":"\n\n\\subsection*{7.1.5 Follow-Up in Case of Early Termination}","confidence":0.9936552047729492,"confidence_rate":0.9998701102938047},{"cnt":[[241,2226],[851,2226],[851,2284],[241,2284]],"region":{"top_left_x":240,"top_left_y":2225,"width":611,"height":59},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c1e923abc4241888204845ad4b93010","type":"section_header","conversion_output":false,"children_ids":["8b211fcfa6524de786fa1291873f9261"],"text":"","text_display":""},{"cnt":[[245,2230],[849,2230],[849,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":605,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b211fcfa6524de786fa1291873f9261","type":"text","conversion_output":true,"parent_id":"5c1e923abc4241888204845ad4b93010","text":"Early Treatment Discontinuation","text_display":"\n\n\\section*{Early Treatment Discontinuation}","confidence":0.9975600242614746,"confidence_rate":0.9999321423765903},{"cnt":[[245,2316],[1882,2316],[1882,2370],[245,2370]],"region":{"top_left_x":244,"top_left_y":2316,"width":1639,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"098592330c2c459cb13dd980850a7ca9","type":"text","conversion_output":true,"text":"Subjects who discontinue treatment prematurely will undergo the assessments planned for Week","text_display":"\n\nSubjects who discontinue treatment prematurely will undergo the assessments planned for Week","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1882,2368],[1882,2417],[245,2417]],"region":{"top_left_x":244,"top_left_y":2367,"width":1639,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71f40efe00ed4c9a8544b0fcf3ff0100","type":"text","conversion_output":true,"text":"104/Visit 22 at the time of discontinuation (see Appendix E). If they are willing to continue in","text_display":" 104/Visit 22 at the time of discontinuation (see Appendix E). If they are willing to continue in","confidence":1,"confidence_rate":1},{"cnt":[[245,2415],[1882,2415],[1882,2466],[245,2466]],"region":{"top_left_x":244,"top_left_y":2414,"width":1639,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72044d1db8274e5eb5363ae614a4f95c","type":"text","conversion_output":true,"text":"the trial, they will undergo all subsequent assessments planned for the remainder of their trial","text_display":" the trial, they will undergo all subsequent assessments planned for the remainder of their trial","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"dea1f248ff644ac98b6bb4047c674a81","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4bb9a8992cb34e0d8584d7a9c3d85179","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"20a2a1051f7648f19b427d88debc20ef","type":"page_info","conversion_output":false,"text":"66/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-067","page":67,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd0c43a251cf4079ad40f02c1d2fcae0","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a44626a2751a41028e7926e10b3f7bc6","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1898d88c41754ffbb348c377f3473a3e","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c966bf4e58f84662a947fe2c181897ef","type":"text","conversion_output":true,"text":"participation (Visit 23 through Visit 28; with no further administration of IMP). Subjects who","text_display":"\nparticipation (Visit 23 through Visit 28; with no further administration of IMP). Subjects who","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,329],[1880,329],[1880,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1636,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bd5fede2eaf4b3fa1328750c7bab259","type":"text","conversion_output":true,"text":"discontinue participation during the extended follow-up phase should have Week 260/Visit 28","text_display":" discontinue participation during the extended follow-up phase should have Week 260/Visit 28","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[950,374],[950,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":706,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb29f97b152343dea71663c6430978cd","type":"text","conversion_output":true,"text":"procedures completed whenever possible.","text_display":" procedures completed whenever possible.","confidence":1,"confidence_rate":1},{"cnt":[[241,460],[690,460],[690,522],[241,522]],"region":{"top_left_x":240,"top_left_y":459,"width":450,"height":64},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"382914639c3042f2a6abacda1768eb85","type":"section_header","conversion_output":false,"children_ids":["d9d2a5f9d41044a7affe7a22c5bbb897"],"text":"","text_display":""},{"cnt":[[245,464],[681,464],[681,518],[245,518]],"region":{"top_left_x":244,"top_left_y":464,"width":438,"height":54},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9d2a5f9d41044a7affe7a22c5bbb897","type":"text","conversion_output":true,"parent_id":"382914639c3042f2a6abacda1768eb85","text":"Early Trial Withdrawal","text_display":"\n\n\\section*{Early Trial Withdrawal}","confidence":1,"confidence_rate":1},{"cnt":[[245,554],[1882,554],[1882,606],[245,606]],"region":{"top_left_x":244,"top_left_y":554,"width":1639,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c33b888b7b074349b479a42da66a0211","type":"text","conversion_output":true,"text":"Subjects who withdraw from the trial should undergo the assessments planned for Week","text_display":"\n\nSubjects who withdraw from the trial should undergo the assessments planned for Week","confidence":1,"confidence_rate":1},{"cnt":[[247,602],[1523,602],[1523,655],[247,655]],"region":{"top_left_x":247,"top_left_y":601,"width":1277,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a350e17503749488f71d7068448b222","type":"text","conversion_output":true,"text":"104/Visit 22 at the time of withdrawal whenever possible (see Appendix E).","text_display":" 104/Visit 22 at the time of withdrawal whenever possible (see Appendix E).","confidence":1,"confidence_rate":1},{"cnt":[[241,687],[1635,687],[1635,758],[241,758]],"region":{"top_left_x":240,"top_left_y":687,"width":1395,"height":72},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f4a49d2e2b4408c8e3a51dd98dfb2f1","type":"section_header","conversion_output":false,"children_ids":["8e11846fc6d54d54ade9781432c8a891"],"text":"","text_display":""},{"cnt":[[245,694],[1635,694],[1635,754],[245,754]],"region":{"top_left_x":244,"top_left_y":693,"width":1391,"height":62},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e11846fc6d54d54ade9781432c8a891","type":"text","conversion_output":true,"parent_id":"5f4a49d2e2b4408c8e3a51dd98dfb2f1","text":"7.2 Demographic and Other Baseline Characteristics","text_display":"\n\n\\subsection*{7.2 Demographic and Other Baseline Characteristics}","confidence":0.5947265625,"confidence_rate":0.9904229412843649},{"cnt":[[245,791],[1884,791],[1884,840],[245,840]],"region":{"top_left_x":244,"top_left_y":790,"width":1641,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51d105d2f5bd47deb707bb804cbc1dc8","type":"text","conversion_output":true,"text":"The demographic variables to be documented will be the subject identifier (to be assigned by the","text_display":"\n\nThe demographic variables to be documented will be the subject identifier (to be assigned by the","confidence":0.9970715045928955,"confidence_rate":0.9999709628786162},{"cnt":[[245,838],[1882,838],[1882,889],[245,889]],"region":{"top_left_x":244,"top_left_y":837,"width":1639,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0683837e96914e5298ed484714bcb8f2","type":"text","conversion_output":true,"text":"IVRS), age, sex, race, weight and height. Weight will also be measured every six months and","text_display":" IVRS), age, sex, race, weight and height. Weight will also be measured every six months and","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1590,885],[1590,939],[245,939]],"region":{"top_left_x":244,"top_left_y":885,"width":1346,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac01ffc49db640709e6e61ee35e2d955","type":"text","conversion_output":true,"text":"height will be measured at the end of the DBPC and extended follow-up phases.","text_display":" height will be measured at the end of the DBPC and extended follow-up phases.","confidence":1,"confidence_rate":1},{"cnt":[[245,975],[1884,975],[1884,1027],[245,1027]],"region":{"top_left_x":244,"top_left_y":975,"width":1641,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"145b4d0cb0bc46efa6691bbfdd67c530","type":"text","conversion_output":true,"text":"A complete medical history should be taken, covering all organ systems, diagnoses so far","text_display":"\n\nA complete medical history should be taken, covering all organ systems, diagnoses so far","confidence":1,"confidence_rate":1},{"cnt":[[245,1023],[1884,1023],[1884,1076],[245,1076]],"region":{"top_left_x":244,"top_left_y":1022,"width":1641,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa3cab71c2344ed7ba8a77d90c153fa7","type":"text","conversion_output":true,"text":"established, medications prescribed (including any vitamins and nutritional supplements taken),","text_display":" established, medications prescribed (including any vitamins and nutritional supplements taken),","confidence":1,"confidence_rate":1},{"cnt":[[245,1072],[1884,1070],[1884,1123],[245,1125]],"region":{"top_left_x":244,"top_left_y":1069,"width":1641,"height":57},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9421cc1c5de44638b73d9e160da08580","type":"text","conversion_output":true,"text":"and surgical interventions performed. The medical history should also cover aspects such as","text_display":" and surgical interventions performed. The medical history should also cover aspects such as","confidence":1,"confidence_rate":1},{"cnt":[[245,1119],[1882,1119],[1882,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1119,"width":1639,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbee4dbb69d4497d976b2f656a5ec1a8","type":"text","conversion_output":true,"text":"allergies, consumption of alcohol, and smoking habits. Particular attention should be given to","text_display":" allergies, consumption of alcohol, and smoking habits. Particular attention should be given to","confidence":1,"confidence_rate":1},{"cnt":[[245,1164],[1038,1164],[1038,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1164,"width":794,"height":59},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d0647b5d2ed45819580fa5a423ad1b0","type":"text","conversion_output":true,"text":"conditions potentially affecting trial eligibility.","text_display":" conditions potentially affecting trial eligibility.","confidence":1,"confidence_rate":1},{"cnt":[[245,1257],[1886,1257],[1886,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1256,"width":1643,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbdd0eddbed44001896d1f03a9bf9f8c","type":"text","conversion_output":true,"text":"Concerning concomitant treatments, particular attention should be given to the subject's use of","text_display":"\n\nConcerning concomitant treatments, particular attention should be given to the subject's use of","confidence":1,"confidence_rate":1},{"cnt":[[243,1302],[1884,1302],[1884,1356],[243,1356]],"region":{"top_left_x":242,"top_left_y":1301,"width":1643,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92b8ba6f15544e2db424310f59f534ca","type":"text","conversion_output":true,"text":"NSAIDs, coxibs, and analgesics in general. These medications must be painstakingly recorded at","text_display":" NSAIDs, coxibs, and analgesics in general. These medications must be painstakingly recorded at","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1884,1354],[1884,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1353,"width":1641,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eff1400fbee0445b9eae0b7a8792c111","type":"text","conversion_output":true,"text":"baseline, as this information is needed for determination of eligibility for the trial. It will also be","text_display":" baseline, as this information is needed for determination of eligibility for the trial. It will also be","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1558,1401],[1558,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1400,"width":1314,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"067a10881d7d4533b3f4eebd46e4370e","type":"text","conversion_output":true,"text":"important to carefully record concomitant medication use throughout the trial.","text_display":" important to carefully record concomitant medication use throughout the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,1489],[1545,1489],[1545,1540],[245,1540]],"region":{"top_left_x":244,"top_left_y":1488,"width":1301,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d65b54e7b5746e28e3864c637a11ff3","type":"text","conversion_output":true,"text":"A complete physical exam should also be performed, as detailed in the MOP.","text_display":"\n\nA complete physical exam should also be performed, as detailed in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1884,1577],[1884,1631],[245,1631]],"region":{"top_left_x":244,"top_left_y":1576,"width":1641,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4bbd8ec7ed04908b6577c80f4dbd90f","type":"text","conversion_output":true,"text":"Concerning the diagnosis of knee OA, it should be established for how long the disease has","text_display":"\nConcerning the diagnosis of knee OA, it should be established for how long the disease has","confidence":1,"confidence_rate":1},{"cnt":[[245,1629],[879,1629],[879,1680],[245,1680]],"region":{"top_left_x":244,"top_left_y":1628,"width":635,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99004c6ee63943d7950ec75472d795b4","type":"text","conversion_output":true,"text":"persisted and how it has been treated.","text_display":" persisted and how it has been treated.","confidence":1,"confidence_rate":1},{"cnt":[[245,1714],[1884,1714],[1884,1768],[245,1768]],"region":{"top_left_x":244,"top_left_y":1714,"width":1641,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd55a2eed46643528166e4d1551321a0","type":"text","conversion_output":true,"text":"The target knee that will be treated with the IMP will be selected during the screening period. In","text_display":"\n\nThe target knee that will be treated with the IMP will be selected during the screening period. In","confidence":1,"confidence_rate":1},{"cnt":[[245,1764],[1682,1764],[1682,1815],[245,1815]],"region":{"top_left_x":244,"top_left_y":1763,"width":1439,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"861a8be7f8954c68841effba0b184562","type":"text","conversion_output":true,"text":"case of bilateral OA, the more symptomatic knee should be chosen as the target knee.","text_display":" case of bilateral OA, the more symptomatic knee should be chosen as the target knee.","confidence":0.998046875,"confidence_rate":0.9999780335577174},{"cnt":[[236,1852],[1087,1852],[1087,1923],[236,1923]],"region":{"top_left_x":236,"top_left_y":1851,"width":852,"height":72},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e104e76d5db54c4eb8b48be3ea9129c2","type":"section_header","conversion_output":false,"children_ids":["8432efc8c11e47e994c6f0a1ef199988","be21b5741c494320a8e558d9b9647545"],"text":"","text_display":""},{"cnt":[[245,1856],[316,1856],[316,1925],[245,1925]],"region":{"top_left_x":244,"top_left_y":1856,"width":72,"height":69},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8432efc8c11e47e994c6f0a1ef199988","type":"text","conversion_output":true,"parent_id":"e104e76d5db54c4eb8b48be3ea9129c2","text":"7.3","text_display":"\n\n\\section*{7.3","confidence":1,"confidence_rate":1},{"cnt":[[593,1858],[1081,1858],[1081,1914],[593,1914]],"region":{"top_left_x":592,"top_left_y":1858,"width":489,"height":57},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be21b5741c494320a8e558d9b9647545","type":"text","conversion_output":true,"parent_id":"e104e76d5db54c4eb8b48be3ea9129c2","text":"Assessment of Efficacy","text_display":" Assessment of Efficacy}","confidence":0.9990236759185791,"confidence_rate":0.9999638228397345},{"cnt":[[243,1951],[1882,1951],[1882,2004],[243,2004]],"region":{"top_left_x":242,"top_left_y":1950,"width":1641,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a5886b7e89441c59980bf31ed3d8f84","type":"text","conversion_output":true,"text":"Assessment of efficacy in this trial will focus on MRI evaluation of treatment effect on knee","text_display":"\n\nAssessment of efficacy in this trial will focus on MRI evaluation of treatment effect on knee","confidence":1,"confidence_rate":1},{"cnt":[[245,1998],[1884,1998],[1884,2052],[245,2052]],"region":{"top_left_x":244,"top_left_y":1998,"width":1641,"height":54},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27584dcfd72b4b06ad398f40ece9f676","type":"text","conversion_output":true,"text":"cartilage. Effects of treatment on OA symptoms and functional limitations will be explored using","text_display":" cartilage. Effects of treatment on OA symptoms and functional limitations will be explored using","confidence":1,"confidence_rate":1},{"cnt":[[245,2047],[1886,2047],[1886,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2047,"width":1643,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7bf6dc6111844c2941d54066cd4bf08","type":"text","conversion_output":true,"text":"the WOMAC questionnaire, the PGA, and the 20 -meter walk test. The recognized endpoint of","text_display":" the WOMAC questionnaire, the PGA, and the 20 -meter walk test. The recognized endpoint of","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,2097],[1884,2097],[1884,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2096,"width":1641,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81c01f7700cf4bee9c699297b81e28bb","type":"text","conversion_output":true,"text":"JSW measured by X-ray will also be used. These assessments are described in the sections","text_display":" JSW measured by X-ray will also be used. These assessments are described in the sections","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,2144],[367,2144],[367,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2144,"width":124,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6790133e1f4a4e73892efbe82c77136b","type":"text","conversion_output":true,"text":"below.","text_display":" below.","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1882,2230],[1882,2284],[245,2284]],"region":{"top_left_x":244,"top_left_y":2230,"width":1639,"height":54},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9db626b858584aab91549ca3cded1850","type":"text","conversion_output":true,"text":"Exploratory analysis of treatment effect on health-related QOL will be performed using the","text_display":"\n\nExploratory analysis of treatment effect on health-related QOL will be performed using the","confidence":1,"confidence_rate":1},{"cnt":[[245,2282],[1884,2282],[1884,2331],[245,2331]],"region":{"top_left_x":244,"top_left_y":2281,"width":1641,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4653517ff31041689a4e39b122a81553","type":"text","conversion_output":true,"text":"KOOS QOL and the MOS SF-36 questionnaire. The NRS will be used to explore treatment","text_display":" KOOS QOL and the MOS SF-36 questionnaire. The NRS will be used to explore treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,2329],[1884,2329],[1884,2378],[245,2378]],"region":{"top_left_x":244,"top_left_y":2328,"width":1641,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c35c4c716284373b8c9b793f8de4b21","type":"text","conversion_output":true,"text":"effect on worst pain in the past 24 hours in the target knee. The ICOAP and the KOOS","text_display":" effect on worst pain in the past 24 hours in the target knee. The ICOAP and the KOOS","confidence":1,"confidence_rate":1},{"cnt":[[245,2376],[1884,2376],[1884,2430],[245,2430]],"region":{"top_left_x":244,"top_left_y":2376,"width":1641,"height":54},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69bf301a965645ed920ef671fd7d69e2","type":"text","conversion_output":true,"text":"Symptom Index questionnaires will be used to explore the effect of treatment on OA-related","text_display":" Symptom Index questionnaires will be used to explore the effect of treatment on OA-related","confidence":1,"confidence_rate":1},{"cnt":[[245,2426],[1884,2426],[1884,2477],[245,2477]],"region":{"top_left_x":244,"top_left_y":2425,"width":1641,"height":53},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ce49ce8c67846ab96449b3e4c163d1a","type":"text","conversion_output":true,"text":"symptomatology in the target knee. The NRS pain scale for the contralateral knee and a scale","text_display":" symptomatology in the target knee. The NRS pain scale for the contralateral knee and a scale","confidence":1,"confidence_rate":1},{"cnt":[[245,2505],[440,2505],[440,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2505,"width":197,"height":41},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e0586f372efd4315bc5c172cef523499","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[391,2544],[391,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":148,"height":46},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"48178d799b004b0f8f1ef2348f7c56bb","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2529],[1601,2529],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2528,"width":93,"height":36},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62ac97652517424cb686356f08294dd1","type":"page_info","conversion_output":false,"text":"67/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-068","page":68,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5188f1617544ddab0f337a0a801c91d","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45e0482b5c3549dea7da2fba91afebcb","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71e0d59119d44e31bf613fcdca008df4","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"065ea96b048844689b63ce0227bb2c79","type":"text","conversion_output":true,"text":"model of the human body identifying potentially painful joints will be used to assess pain in non-","text_display":"\nmodel of the human body identifying potentially painful joints will be used to assess pain in non","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1880,329],[1880,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1636,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3371633b66bb44d89ebec2389d46c3c2","type":"text","conversion_output":true,"text":"target joints and the progression of OA. The PGIC will be used to measure the subject's","text_display":"target joints and the progression of OA. The PGIC will be used to measure the subject's","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,378],[1880,378],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":1636,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff9e941f73784c1ca0f48570f02a8db5","type":"text","conversion_output":true,"text":"assessment of the clinical importance of their improvement or worsening over the course of the","text_display":" assessment of the clinical importance of their improvement or worsening over the course of the","confidence":1,"confidence_rate":1},{"cnt":[[245,423],[1218,423],[1218,475],[245,475]],"region":{"top_left_x":244,"top_left_y":423,"width":975,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2fae8f9ce5141db9c7607362744b150","type":"text","conversion_output":true,"text":"trial. See Section 7.7 for description of these assessments.","text_display":" trial. See Section 7.7 for description of these assessments.","confidence":0.99853515625,"confidence_rate":0.9999784426193857},{"cnt":[[245,511],[1880,511],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":511,"width":1636,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b95dbf776be4801b77256c02d3ad154","type":"text","conversion_output":true,"text":"The OMERACT-OARSI responder rate ((1); see Section 8.3.4) at 2 years will also be","text_display":"\n\nThe OMERACT-OARSI responder rate ((1); see Section 8.3.4) at 2 years will also be","confidence":0.9926891257055104,"confidence_rate":0.9999175569974083},{"cnt":[[245,561],[1880,561],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":560,"width":1636,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ad7fc8790824b179821d324f4db289a","type":"text","conversion_output":true,"text":"determined as an exploratory analysis, based on assessment of pain and function using the","text_display":" determined as an exploratory analysis, based on assessment of pain and function using the","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1094,610],[1094,655],[245,655]],"region":{"top_left_x":244,"top_left_y":610,"width":850,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0d626be7f03487092c411b15603ccbb","type":"text","conversion_output":true,"text":"WOMAC and the PGA described in Section 7.3.3.","text_display":" WOMAC and the PGA described in Section 7.3.3.","confidence":1,"confidence_rate":1},{"cnt":[[245,698],[1880,698],[1880,750],[245,750]],"region":{"top_left_x":244,"top_left_y":698,"width":1636,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"789da9457f3a41228236f7b03bfa6d18","type":"text","conversion_output":true,"text":"The rationale for the selection of efficacy measures and the timing of assessments is presented in","text_display":"\n\nThe rationale for the selection of efficacy measures and the timing of assessments is presented in","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,748],[453,748],[453,793],[245,793]],"region":{"top_left_x":244,"top_left_y":747,"width":210,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7ba51460cd241f0be5c11d9ae644909","type":"text","conversion_output":true,"text":"Section 5.2.","text_display":" Section 5.2.","confidence":1,"confidence_rate":1},{"cnt":[[241,834],[1225,834],[1225,904],[241,904]],"region":{"top_left_x":240,"top_left_y":833,"width":985,"height":72},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c166c32263e42999c71609e816a88d0","type":"section_header","conversion_output":false,"children_ids":["3b1c9f58ee7e417bae794f1609d14a5a"],"text":"","text_display":""},{"cnt":[[245,842],[1218,842],[1218,900],[245,900]],"region":{"top_left_x":244,"top_left_y":842,"width":975,"height":59},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b1c9f58ee7e417bae794f1609d14a5a","type":"text","conversion_output":true,"parent_id":"7c166c32263e42999c71609e816a88d0","text":"7.3.1 Magnetic Resonance Imaging","text_display":"\n\n\\subsection*{7.3.1 Magnetic Resonance Imaging}","confidence":0.99951171875,"confidence_rate":0.9999868000736574},{"cnt":[[241,932],[520,932],[520,990],[241,990]],"region":{"top_left_x":240,"top_left_y":932,"width":280,"height":59},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12abb78eba2b49949ae19b26262c7eeb","type":"section_header","conversion_output":false,"children_ids":["eb010dc1e843490cb18a0bcb34c16454"],"text":"","text_display":""},{"cnt":[[245,937],[513,937],[513,986],[245,986]],"region":{"top_left_x":244,"top_left_y":936,"width":270,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb010dc1e843490cb18a0bcb34c16454","type":"text","conversion_output":true,"parent_id":"12abb78eba2b49949ae19b26262c7eeb","text":"MRI Scanning","text_display":"\n\n\\section*{MRI Scanning}","confidence":1,"confidence_rate":1},{"cnt":[[245,1023],[1880,1023],[1880,1072],[245,1072]],"region":{"top_left_x":244,"top_left_y":1022,"width":1636,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26eb1eb2d64f40a8816e7926834982d8","type":"text","conversion_output":true,"text":"MRI scanning will be performed using a high-resolution, 3-dimensional MRI machine with a","text_display":"\n\nMRI scanning will be performed using a high-resolution, 3-dimensional MRI machine with a","confidence":0.94873046875,"confidence_rate":0.9994342403520352},{"cnt":[[245,1070],[1609,1070],[1609,1124],[245,1124]],"region":{"top_left_x":244,"top_left_y":1069,"width":1366,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f50b7c3e445d428e9ecee3ff6020c0a7","type":"text","conversion_output":true,"text":"commercially available dedicated knee coil. A 1.5 Tesla machine should be used.","text_display":" commercially available dedicated knee coil. A 1.5 Tesla machine should be used.","confidence":0.99365234375,"confidence_rate":0.9999241946795269},{"cnt":[[245,1160],[1880,1160],[1880,1214],[245,1214]],"region":{"top_left_x":244,"top_left_y":1160,"width":1636,"height":54},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60ed12cfa0ff43e6b1ebb750cf4adece","type":"text","conversion_output":true,"text":"It is recommended that machines from the same manufacturer be used to scan a given subject","text_display":"\n\nIt is recommended that machines from the same manufacturer be used to scan a given subject","confidence":1,"confidence_rate":1},{"cnt":[[245,1212],[587,1212],[587,1261],[245,1261]],"region":{"top_left_x":244,"top_left_y":1211,"width":343,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ea81bac92aa4862b538f126cfcc18e0","type":"text","conversion_output":true,"text":"throughout the trial.","text_display":" throughout the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,1298],[1051,1298],[1051,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1297,"width":807,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"491b08b924f6474abb240f0950d8b7fb","type":"text","conversion_output":true,"text":"The scanning procedure is detailed in the MOP.","text_display":"\n\nThe scanning procedure is detailed in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[241,1386],[505,1386],[505,1446],[241,1446]],"region":{"top_left_x":240,"top_left_y":1385,"width":265,"height":61},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6635bfbab1234f6b80912be1f234e405","type":"section_header","conversion_output":false,"children_ids":["392b4cb6322c49e88e560a1b16b329f6"],"text":"","text_display":""},{"cnt":[[245,1392],[501,1392],[501,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1392,"width":257,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"392b4cb6322c49e88e560a1b16b329f6","type":"text","conversion_output":true,"parent_id":"6635bfbab1234f6b80912be1f234e405","text":"MRI Analysis","text_display":"\n\n\\section*{MRI Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[245,1478],[1880,1478],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1478,"width":1636,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81dc7e7ebfb34ba1842b8d27c5619a0e","type":"text","conversion_output":true,"text":"The trial's MRI endpoints will be addressed through quantitative MRI assessment of cartilage","text_display":"\n\nThe trial's MRI endpoints will be addressed through quantitative MRI assessment of cartilage","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1635,1525],[1635,1579],[245,1579]],"region":{"top_left_x":244,"top_left_y":1525,"width":1391,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"209245459d794492ae9805c2347cde96","type":"text","conversion_output":true,"text":"thickness and volume and semi-quantitative MRI assessment of cartilage structure.","text_display":" thickness and volume and semi-quantitative MRI assessment of cartilage structure.","confidence":1,"confidence_rate":1},{"cnt":[[245,1616],[806,1616],[806,1669],[245,1669]],"region":{"top_left_x":244,"top_left_y":1615,"width":562,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1ec8288bdb842ebac75bd2dcd6c9704","type":"text","conversion_output":true,"text":"MRI scans will be read centrally.","text_display":"\n\nMRI scans will be read centrally.","confidence":1,"confidence_rate":1},{"cnt":[[241,1702],[763,1702],[763,1760],[241,1760]],"region":{"top_left_x":240,"top_left_y":1701,"width":523,"height":59},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6452f01e57ce4474a366627961e40b5d","type":"section_header","conversion_output":false,"children_ids":["674fdfe225fa4c4fa393b07683194ad3"],"text":"","text_display":""},{"cnt":[[245,1706],[758,1706],[758,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1705,"width":515,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"674fdfe225fa4c4fa393b07683194ad3","type":"text","conversion_output":true,"parent_id":"6452f01e57ce4474a366627961e40b5d","text":"Quantitative MRI Assessment","text_display":"\n\n\\section*{Quantitative MRI Assessment}","confidence":1,"confidence_rate":1},{"cnt":[[245,1794],[1880,1794],[1880,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1793,"width":1636,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aedd4158d1f343bf83a2525ee7242e23","type":"text","conversion_output":true,"text":"OA is characterized by a progressive loss of cartilage that can be quantified by MRI. MRI is","text_display":"\n\nOA is characterized by a progressive loss of cartilage that can be quantified by MRI. MRI is","confidence":1,"confidence_rate":1},{"cnt":[[245,1843],[1880,1843],[1880,1895],[245,1895]],"region":{"top_left_x":244,"top_left_y":1843,"width":1636,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47e401fb6d134f8d83abd1ed720ad171","type":"text","conversion_output":true,"text":"believed to detect structural changes faster than X-ray, although only JSW as measured by X-ray","text_display":" believed to detect structural changes faster than X-ray, although only JSW as measured by X-ray","confidence":1,"confidence_rate":1},{"cnt":[[245,1891],[1884,1891],[1884,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1890,"width":1641,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24a28e9b497b459487be6ff3eaa01d6d","type":"text","conversion_output":true,"text":"is accepted as a primary structural endpoint in confirmatory OA trials. For the purpose of","text_display":" is accepted as a primary structural endpoint in confirmatory OA trials. For the purpose of","confidence":0.99609375,"confidence_rate":0.9999588019084422},{"cnt":[[245,1938],[1880,1938],[1880,1989],[245,1989]],"region":{"top_left_x":244,"top_left_y":1937,"width":1636,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38d5d9a56bd941ac8498f06be72381c2","type":"text","conversion_output":true,"text":"quantification, the joint is divided into different compartments that may be more or less affected","text_display":" quantification, the joint is divided into different compartments that may be more or less affected","confidence":1,"confidence_rate":1},{"cnt":[[245,1985],[1880,1985],[1880,2039],[245,2039]],"region":{"top_left_x":244,"top_left_y":1985,"width":1636,"height":54},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecba97d7febe4b29bf505d2d1ba70bac","type":"text","conversion_output":true,"text":"by OA. Quantitative MRI analysis in this trial will focus on the total knee and on the lateral and","text_display":" by OA. Quantitative MRI analysis in this trial will focus on the total knee and on the lateral and","confidence":1,"confidence_rate":1},{"cnt":[[245,2037],[1394,2037],[1394,2086],[245,2086]],"region":{"top_left_x":244,"top_left_y":2036,"width":1151,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73d8280034394ed0aef4abbf9a208a12","type":"text","conversion_output":true,"text":"medial femorotibial compartments (LFTC and MFTC, respectively).","text_display":" medial femorotibial compartments (LFTC and MFTC, respectively).","confidence":1,"confidence_rate":1},{"cnt":[[245,2118],[1764,2118],[1764,2174],[245,2174]],"region":{"top_left_x":244,"top_left_y":2118,"width":1520,"height":57},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f40fbd0ad544fffa5205ccaa1729c2f","type":"text","conversion_output":true,"text":"Quantitative MRI analysis for this trial will be performed under the direction of PPD","text_display":"\n\nQuantitative MRI analysis for this trial will be performed under the direction of PPD","confidence":1,"confidence_rate":1},{"cnt":[[243,2161],[1195,2161],[1195,2228],[243,2228]],"region":{"top_left_x":242,"top_left_y":2161,"width":953,"height":67},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e064b73c2bc4272ba9dfe68045327d4","type":"form_field","conversion_output":true,"text":"","text_display":"\n\\(\\_\\_\\_\\_\\)"},{"cnt":[[1177,2170],[1201,2170],[1201,2230],[1177,2230]],"region":{"top_left_x":1177,"top_left_y":2169,"width":24,"height":62},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f0f1f4292a840bbb16dee3a8edf7702","type":"text","conversion_output":true,"text":".","text_display":" .","confidence":0.95751953125,"confidence_rate":0.9927912486037641},{"cnt":[[241,2258],[853,2258],[853,2316],[241,2316]],"region":{"top_left_x":240,"top_left_y":2258,"width":613,"height":59},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d50191c9200a4f858af6796c5dbd4cf1","type":"section_header","conversion_output":false,"children_ids":["35bc5f219b1c4c0da35ccab7162abc3c"],"text":"","text_display":""},{"cnt":[[245,2262],[849,2262],[849,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2262,"width":605,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35bc5f219b1c4c0da35ccab7162abc3c","type":"text","conversion_output":true,"parent_id":"d50191c9200a4f858af6796c5dbd4cf1","text":"Semi-quantitative MRI Assessment","text_display":"\n\n\\section*{Semi-quantitative MRI Assessment}","confidence":1,"confidence_rate":1},{"cnt":[[245,2350],[1880,2350],[1880,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2350,"width":1636,"height":52},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66ae61ccf15a4f42bb7b92fb53702c1e","type":"text","conversion_output":true,"text":"Semi-quantitative assessment of the target knee will be performed using the Whole Organ","text_display":"\n\nSemi-quantitative assessment of the target knee will be performed using the Whole Organ","confidence":1,"confidence_rate":1},{"cnt":[[245,2400],[1880,2400],[1880,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2399,"width":1636,"height":53},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"376f02c04ba145679b3cb5100494534c","type":"text","conversion_output":true,"text":"Magnetic Resonance Imaging Score (WORMS (18)) and the Boston-Leeds Osteoarthritis Knee","text_display":" Magnetic Resonance Imaging Score (WORMS (18)) and the Boston-Leeds Osteoarthritis Knee","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[245,2445],[694,2445],[694,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2444,"width":450,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b8a4461638a4c8286272e33a550522d","type":"text","conversion_output":true,"text":"Score (BLOKS (24),(25)).","text_display":" Score (BLOKS (24),(25)).","confidence":0.9970703125,"confidence_rate":0.9998988331372023},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"569ca2385d2e41a7b51cfcb8255d8003","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c75c5cb9cd3b4d548ac6074298e9028d","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e2e1e6aacff4e73be3ef85989171950","type":"page_info","conversion_output":false,"text":"68/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-069","page":69,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3e4e264fe8a46a4a49dc46841ceebd9","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e6b47408d034566bda23fced8d8309d","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e73efbf0897480b8617300b018aab37","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c58a39baaf841018705db7e8433c74a","type":"text","conversion_output":true,"text":"The WORMS permits whole-organ assessment of the knee in OA based on conventional MRI","text_display":"\n\nThe WORMS permits whole-organ assessment of the knee in OA based on conventional MRI","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1880,329],[1880,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1636,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58afbcaefc814f5c80e54ebb8f04caf9","type":"text","conversion_output":true,"text":"images, and inter-observer agreement is high among trained readers. In its complete form,","text_display":" images, and inter-observer agreement is high among trained readers. In its complete form,","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1880,374],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94a032d4c36c4d5591bc364ca24f7475","type":"text","conversion_output":true,"text":"WORMS incorporates assessment of 14 features: articular cartilage integrity (signal and","text_display":" WORMS incorporates assessment of 14 features: articular cartilage integrity (signal and","confidence":1,"confidence_rate":1},{"cnt":[[245,423],[1880,423],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":423,"width":1636,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de6eac32fc50486da3d9751c274ef628","type":"text","conversion_output":true,"text":"morphology), subarticular bone marrow abnormality (bone marrow edema), subarticular cysts,","text_display":" morphology), subarticular bone marrow abnormality (bone marrow edema), subarticular cysts,","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1880,473],[1880,522],[245,522]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1b0974391c14953b0b0261666f0eafb","type":"text","conversion_output":true,"text":"subarticular bone attrition, marginal osteophytes, medial and lateral meniscal integrity, anterior","text_display":" subarticular bone attrition, marginal osteophytes, medial and lateral meniscal integrity, anterior","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1880,520],[1880,571],[245,571]],"region":{"top_left_x":244,"top_left_y":519,"width":1636,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"302d3bd6ddc541118c8544ca556ffadf","type":"text","conversion_output":true,"text":"and posterior cruciate ligament integrity, medial and lateral collateral ligament integrity,","text_display":" and posterior cruciate ligament integrity, medial and lateral collateral ligament integrity,","confidence":1,"confidence_rate":1},{"cnt":[[245,567],[1553,567],[1553,621],[245,621]],"region":{"top_left_x":244,"top_left_y":567,"width":1310,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73b933d2bae442b1a1f56b3619074349","type":"text","conversion_output":true,"text":"synovitis/effusion, intra-articular loose bodies, and periarticular cysts/bursitis.","text_display":" synovitis/effusion, intra-articular loose bodies, and periarticular cysts/bursitis.","confidence":1,"confidence_rate":1},{"cnt":[[245,710],[245,655],[1882,657],[1882,712]],"region":{"top_left_x":244,"top_left_y":655,"width":1639,"height":58},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eb7521732b54ee3b060b13b6c49e9bb","type":"text","conversion_output":true,"text":"The BLOKS scoring method assesses 9 intra-articular regions and contains 8 items, including","text_display":"\n\nThe BLOKS scoring method assesses 9 intra-articular regions and contains 8 items, including","confidence":1,"confidence_rate":1},{"cnt":[[245,705],[1880,705],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":704,"width":1636,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f013f1b561d04aac8c886ff4fd3653e9","type":"text","conversion_output":true,"text":"features of bone marrow lesions, cartilage, osteophytes, synovitis, effusions and ligaments.","text_display":" features of bone marrow lesions, cartilage, osteophytes, synovitis, effusions and ligaments.","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1880,752],[1880,806],[245,806]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"228d438de2a94acb92a3df3e9278091e","type":"text","conversion_output":true,"text":"Possible scores for each feature range from 0 to 3 . Maximal bone marrow lesion size using the","text_display":" Possible scores for each feature range from 0 to 3 . Maximal bone marrow lesion size using the","confidence":0.95849609375,"confidence_rate":0.9995963691771997},{"cnt":[[245,799],[1880,799],[1880,853],[245,853]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fe54c99d8334a9798e14377b78cdae0","type":"text","conversion_output":true,"text":"BLOKS has been shown to have a positive linear relation with VAS pain, while this has not been","text_display":" BLOKS has been shown to have a positive linear relation with VAS pain, while this has not been","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[245,849],[776,849],[776,896],[245,896]],"region":{"top_left_x":244,"top_left_y":848,"width":532,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c11dff2739e14b8d836c71529ef58cc4","type":"text","conversion_output":true,"text":"demonstrated for the WORMS.","text_display":" demonstrated for the WORMS.","confidence":1,"confidence_rate":1},{"cnt":[[245,937],[1880,937],[1880,990],[245,990]],"region":{"top_left_x":244,"top_left_y":936,"width":1636,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2fc74d684014705b7919a15dee475dc","type":"text","conversion_output":true,"text":"Semi-quantitative MRI analysis for this trial will be performed and centrally analyzed as","text_display":"\n\nSemi-quantitative MRI analysis for this trial will be performed and centrally analyzed as","confidence":1,"confidence_rate":1},{"cnt":[[245,986],[1033,986],[1033,1038],[245,1038]],"region":{"top_left_x":244,"top_left_y":986,"width":790,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f0f33407db14b168b8e75b1e5b70a61","type":"text","conversion_output":true,"text":"described in the Manual of Procedures (MOP).","text_display":" described in the Manual of Procedures (MOP).","confidence":1,"confidence_rate":1},{"cnt":[[241,1072],[1119,1072],[1119,1141],[241,1141]],"region":{"top_left_x":240,"top_left_y":1072,"width":880,"height":69},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05a63effb7454781b85af962a289a156","type":"section_header","conversion_output":false,"children_ids":["5a65971d1cb74ce7bf97954ef94dba1b"],"text":"","text_display":""},{"cnt":[[245,1079],[1113,1079],[1113,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1078,"width":869,"height":59},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a65971d1cb74ce7bf97954ef94dba1b","type":"text","conversion_output":true,"parent_id":"05a63effb7454781b85af962a289a156","text":"7.3.2 WOMAC Questionnaire","text_display":"\n\n\\subsection*{7.3.2 WOMAC Questionnaire}","confidence":0.9990234375,"confidence_rate":0.9999674325420703},{"cnt":[[245,1173],[1880,1173],[1880,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1173,"width":1636,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6a1571bce094fb5b973873286ab6502","type":"text","conversion_output":true,"text":"The self-administered 24-question WOMAC Version 3.1 ((26); see Appendix C) will be used to","text_display":"\n\nThe self-administered 24-question WOMAC Version 3.1 ((26); see Appendix C) will be used to","confidence":0.7175602912902832,"confidence_rate":0.9966190110586},{"cnt":[[245,1220],[1137,1220],[1137,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1220,"width":893,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e68f479ee814454cb69887d30490bdf1","type":"text","conversion_output":true,"text":"assess pain, disability, and joint stiffness in the knee.","text_display":" assess pain, disability, and joint stiffness in the knee.","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1880,1311],[1880,1364],[245,1364]],"region":{"top_left_x":244,"top_left_y":1310,"width":1636,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"265f2061e6c54f3da867304e40946bb2","type":"text","conversion_output":true,"text":"Subjects will answer all of the 24 questions themselves, using an 11-box numerical rating scale","text_display":"\n\nSubjects will answer all of the 24 questions themselves, using an 11-box numerical rating scale","confidence":0.76611328125,"confidence_rate":0.9974166897519301},{"cnt":[[245,1358],[1880,1358],[1880,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1357,"width":1636,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecb87328323e4afcb81d4b4df3f89a9e","type":"text","conversion_output":true,"text":"(with categories of 0 to 10), with reference to the past 48 hours. Different forms of the","text_display":" (with categories of 0 to 10), with reference to the past 48 hours. Different forms of the","confidence":0.54296875,"confidence_rate":0.9939115749221309},{"cnt":[[245,1405],[1880,1405],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b31c043002c43e6b2a76d4fa715fae5","type":"text","conversion_output":true,"text":"questionnaire exist for the right and the left knees: in order to reduce confounding of WOMAC","text_display":" questionnaire exist for the right and the left knees: in order to reduce confounding of WOMAC","confidence":1,"confidence_rate":1},{"cnt":[[245,1457],[1880,1457],[1880,1506],[245,1506]],"region":{"top_left_x":244,"top_left_y":1456,"width":1636,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"518adf2e62d04455b9fe8d33ddb27104","type":"text","conversion_output":true,"text":"responses by symptoms in the contralateral knee, subjects will use the WOMAC questionnaire","text_display":" responses by symptoms in the contralateral knee, subjects will use the WOMAC questionnaire","confidence":0.9980475902557373,"confidence_rate":0.9999794284412753},{"cnt":[[245,1504],[694,1504],[694,1553],[245,1553]],"region":{"top_left_x":244,"top_left_y":1503,"width":450,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"291ee6adaf044251b01ef99fe2dfb7d3","type":"text","conversion_output":true,"text":"specific to the target knee.","text_display":" specific to the target knee.","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[1880,1590],[1880,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1589,"width":1636,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdcb105cfb6a4e2ca6a5baf13188358d","type":"text","conversion_output":true,"text":"For administration of the questionnaire, instructions for the WOMAC 3.1 Index should be","text_display":"\n\nFor administration of the questionnaire, instructions for the WOMAC 3.1 Index should be","confidence":0.978515625,"confidence_rate":0.999771410089028},{"cnt":[[245,1641],[410,1641],[410,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1641,"width":167,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"415ea219ee27488f9a78c4cd7f1e9a0b","type":"text","conversion_output":true,"text":"followed.","text_display":" followed.","confidence":1,"confidence_rate":1},{"cnt":[[245,1727],[1880,1727],[1880,1781],[245,1781]],"region":{"top_left_x":244,"top_left_y":1727,"width":1636,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8be87f8401aa4a64909f9f7f0d089bf0","type":"text","conversion_output":true,"text":"The WOMAC is widely used in clinical trials in hip and knee OA, and has been extensively","text_display":"\n\nThe WOMAC is widely used in clinical trials in hip and knee OA, and has been extensively","confidence":1,"confidence_rate":1},{"cnt":[[245,1779],[1704,1779],[1704,1833],[245,1833]],"region":{"top_left_x":244,"top_left_y":1778,"width":1460,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c74b82ce5786418d9205cfa0a2e0ab2c","type":"text","conversion_output":true,"text":"validated. Appropriate validated translations will be used in each participating country.","text_display":" validated. Appropriate validated translations will be used in each participating country.","confidence":1,"confidence_rate":1},{"cnt":[[245,1865],[1880,1865],[1880,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1864,"width":1636,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f57429cf76c24fc98f37fac8dbe42514","type":"text","conversion_output":true,"text":"The questionnaire addresses the degree of pain experienced with different activities or positions","text_display":"\n\nThe questionnaire addresses the degree of pain experienced with different activities or positions","confidence":1,"confidence_rate":1},{"cnt":[[245,1916],[1880,1916],[1880,1968],[245,1968]],"region":{"top_left_x":244,"top_left_y":1916,"width":1636,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13f4addb49d84862aacd72fe7c8cf2bb","type":"text","conversion_output":true,"text":"(5 questions), the degree and timing of joint stiffness (2 questions), and the degree of difficulty","text_display":" (5 questions), the degree and timing of joint stiffness (2 questions), and the degree of difficulty","confidence":0.9970722198486328,"confidence_rate":0.9999718073735385},{"cnt":[[245,1964],[1880,1964],[1880,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1963,"width":1636,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3d6f1d650bd4028818520c568671370","type":"text","conversion_output":true,"text":"experienced in performing daily activities ( 17 questions). The maximum possible total score,","text_display":" experienced in performing daily activities ( 17 questions). The maximum possible total score,","confidence":0.99609375,"confidence_rate":0.9999612492724017},{"cnt":[[245,2011],[1884,2011],[1884,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2010,"width":1641,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b1c642d536b490db0978e8b8d1ccfb3","type":"text","conversion_output":true,"text":"indicating the worst possible OA symptoms, is 240 points. For convenience and ease of","text_display":" indicating the worst possible OA symptoms, is 240 points. For convenience and ease of","confidence":0.54638671875,"confidence_rate":0.993913263553107},{"cnt":[[245,2058],[1454,2058],[1454,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2058,"width":1211,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1182d8aca26d41408a9a642cd369c7a4","type":"text","conversion_output":true,"text":"interpretation, all scores will be normalized on scales of 0 to 100 points.","text_display":" interpretation, all scores will be normalized on scales of 0 to 100 points.","confidence":0.998535871389322,"confidence_rate":0.9999829629184545},{"cnt":[[245,2148],[1880,2148],[1880,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2148,"width":1636,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7babcc3ab041450795bba6fcd7b5a097","type":"text","conversion_output":true,"text":"The minimum clinically important difference in WOMAC scores is considered to be about \\(10 \\%\\)","text_display":"\n\nThe minimum clinically important difference in WOMAC scores is considered to be about \\(10 \\%\\)","confidence":0.998046875,"confidence_rate":0.9999789783410032},{"cnt":[[245,2196],[864,2196],[864,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2195,"width":620,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df1714c855fb4532810a467b8152cf5c","type":"text","conversion_output":true,"text":"of the maximum possible score (27).","text_display":" of the maximum possible score (27).","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"16b94123a35147c689f952183fb31eed","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"41982c1c22e4412c8c2bb10a25994332","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e82146598534f3c87f4f3e13ecb62bb","type":"page_info","conversion_output":false,"text":"69/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-070","page":70,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3b806f4c0f446318a80b88f0f378e1e","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ea792d1496f43ed87573d107e0cf521","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cc2e3db83894a5ebe71634068bc241c","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,277],[1199,277],[1199,339],[241,339]],"region":{"top_left_x":240,"top_left_y":277,"width":959,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22f888570e95456d874798bfcdf0fb9f","type":"section_header","conversion_output":false,"children_ids":["5e82a98c4aa34f04a02e89bf63841597"],"text":"","text_display":""},{"cnt":[[245,284],[1195,284],[1195,333],[245,333]],"region":{"top_left_x":244,"top_left_y":283,"width":951,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e82a98c4aa34f04a02e89bf63841597","type":"text","conversion_output":true,"parent_id":"22f888570e95456d874798bfcdf0fb9f","text":"7.3.3 Patient's Global Assessment","text_display":"\n\n\\subsection*{7.3.3 Patient's Global Assessment}","confidence":0.97607421875,"confidence_rate":0.9993629227131499},{"cnt":[[245,378],[1882,378],[1882,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":1639,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f50ed76c60104a6fbce6b106fe1611c9","type":"text","conversion_output":true,"text":"In the Patient's Global Assessment (PGA) used in this trial, subjects will be asked to answer the","text_display":"\n\nIn the Patient's Global Assessment (PGA) used in this trial, subjects will be asked to answer the","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,425],[1235,425],[1235,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":992,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0751beeab9e74c84bfb094b615dcc204","type":"text","conversion_output":true,"text":"following question using an 11-box numerical rating scale:","text_display":" following question using an 11-box numerical rating scale:","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1880,516],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9802b058faa4e1d9ccf49f43036e37d","type":"text","conversion_output":true,"text":"\"Considering all the ways your osteoarthritis of the knee has affected you during the last 48","text_display":"\n\"Considering all the ways your osteoarthritis of the knee has affected you during the last 48","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1882,563],[1882,614],[245,614]],"region":{"top_left_x":244,"top_left_y":562,"width":1639,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2e3ec68ddf7453c9812fb1904bc0175","type":"text","conversion_output":true,"text":"hours, circle the number that best describes the impact of your knee osteoarthritis on your daily","text_display":" hours, circle the number that best describes the impact of your knee osteoarthritis on your daily","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[339,610],[339,655],[245,655]],"region":{"top_left_x":244,"top_left_y":610,"width":96,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed30b5bb5fa8488180f4b95cf5259758","type":"text","conversion_output":true,"text":"life.\"","text_display":" life.\"","confidence":1,"confidence_rate":1},{"cnt":[[247,655],[1772,655],[1772,733],[247,733]],"region":{"top_left_x":247,"top_left_y":655,"width":1526,"height":78},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b216358a8e84fabbdcfc17293dc860e","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|}\n\\hline 0 & 1 & 2 & 3 & 4 & 5 & 6 & 7 & 8 & 9 & 10 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|}\n\\hline 0 & 1 & 2 & 3 & 4 & 5 & 6 & 7 & 8 & 9 & 10 \\\\\n\\hline\n\\end{tabular}","confidence":0.8381491990403447,"confidence_rate":0.9976795496730752},{"cnt":[[277,739],[367,739],[367,776],[277,776]],"region":{"top_left_x":277,"top_left_y":739,"width":91,"height":37},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaeda2fd3b4a4fd4857b9ec6bfa35344","type":"text","conversion_output":true,"text":"None","text_display":"\n\nNone","confidence":1,"confidence_rate":1},{"cnt":[[1629,735],[1764,735],[1764,776],[1629,776]],"region":{"top_left_x":1628,"top_left_y":734,"width":136,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"277097d41c2541448296c6f523310bf5","type":"text","conversion_output":true,"text":"Extreme","text_display":"\nExtreme","confidence":1,"confidence_rate":1},{"cnt":[[241,829],[930,829],[930,898],[241,898]],"region":{"top_left_x":240,"top_left_y":829,"width":691,"height":70},"line":14,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"d89b95c80daf4814a07895e7e2384257","type":"section_header","conversion_output":false,"children_ids":["1d9388f5cfb14c589f7b0b3e30b735ef"],"text":"","text_display":""},{"cnt":[[245,834],[926,834],[926,892],[245,892]],"region":{"top_left_x":244,"top_left_y":833,"width":682,"height":59},"line":15,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"1d9388f5cfb14c589f7b0b3e30b735ef","type":"text","conversion_output":true,"parent_id":"d89b95c80daf4814a07895e7e2384257","text":"7.3.4 X-Ray Imaging","text_display":"\n\n\\subsection*{7.3.4 X-Ray Imaging}","confidence":1,"confidence_rate":1},{"cnt":[[241,924],[711,924],[711,986],[241,986]],"region":{"top_left_x":240,"top_left_y":923,"width":472,"height":64},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59cf3c7ad0584cd4aec76f2eb19d8808","type":"section_header","conversion_output":false,"children_ids":["5fcef158e9a144919beed27c1b9b7043"],"text":"","text_display":""},{"cnt":[[245,932],[707,932],[707,982],[245,982]],"region":{"top_left_x":244,"top_left_y":932,"width":463,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fcef158e9a144919beed27c1b9b7043","type":"text","conversion_output":true,"parent_id":"59cf3c7ad0584cd4aec76f2eb19d8808","text":"X-Ray Image Acquisition","text_display":"\n\n\\section*{X-Ray Image Acquisition}","confidence":1,"confidence_rate":1},{"cnt":[[245,1018],[1882,1018],[1882,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1018,"width":1639,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efa0b3a4324743a9a3ec1ad562b59b7a","type":"text","conversion_output":true,"text":"Fixed flexion radiography will be used for the measurement of JSW. For the posterior-anterior","text_display":"\n\nFixed flexion radiography will be used for the measurement of JSW. For the posterior-anterior","confidence":1,"confidence_rate":1},{"cnt":[[245,1068],[1880,1068],[1880,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1067,"width":1636,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44b78d4f152f46119fc18b6b0b5d888a","type":"text","conversion_output":true,"text":"projection of the target knee, the distance between focus and film will be equivalent to 183 cm","text_display":" projection of the target knee, the distance between focus and film will be equivalent to 183 cm","confidence":1,"confidence_rate":1},{"cnt":[[245,1113],[1880,1113],[1880,1167],[245,1167]],"region":{"top_left_x":244,"top_left_y":1112,"width":1636,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a4fb2d39c384fc7911beeef19ec2a12","type":"text","conversion_output":true,"text":"( 72 inches), and subjects must be positioned with their knees flexed at an angle of \\(20-30\\) degrees","text_display":" ( 72 inches), and subjects must be positioned with their knees flexed at an angle of \\(20-30\\) degrees","confidence":0.9848897362826392,"confidence_rate":0.9998603254715753},{"cnt":[[245,1162],[1880,1162],[1880,1214],[245,1214]],"region":{"top_left_x":244,"top_left_y":1162,"width":1636,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a482ab2ad4a48fd9c74630785434b05","type":"text","conversion_output":true,"text":"and their feet rotated internally at an angle of 10 degrees. Foot maps and a standardized","text_display":" and their feet rotated internally at an angle of 10 degrees. Foot maps and a standardized","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,1212],[823,1212],[823,1261],[245,1261]],"region":{"top_left_x":244,"top_left_y":1211,"width":579,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4caa3c0371b4eebbfe90e549dc286c6","type":"text","conversion_output":true,"text":"radiological protocol will be used.","text_display":" radiological protocol will be used.","confidence":1,"confidence_rate":1},{"cnt":[[245,1300],[1880,1300],[1880,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1299,"width":1636,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3771f2d2f8a64113a5969ddb1426d59a","type":"text","conversion_output":true,"text":"During the screening period, at the end of the DBPC treatment phase, and at the end of the","text_display":"\n\nDuring the screening period, at the end of the DBPC treatment phase, and at the end of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1880,1349],[1880,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1349,"width":1636,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72b10dd6a0a0408abf95e4b8e13c1a08","type":"text","conversion_output":true,"text":"extended follow-up phase, X-rays of both the target knee and the contralateral knee will be","text_display":" extended follow-up phase, X-rays of both the target knee and the contralateral knee will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1880,1396],[1880,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1636,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32b25cd6a5804fa194bd07d16d234d35","type":"text","conversion_output":true,"text":"performed. At other time points, X-rays will be performed for the target knee only. A long-axis","text_display":" performed. At other time points, X-rays will be performed for the target knee only. A long-axis","confidence":0.9990234375,"confidence_rate":0.999990229651252},{"cnt":[[245,1444],[1884,1444],[1884,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1443,"width":1641,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e03aefd92b64887811af9f034c0d937","type":"text","conversion_output":true,"text":"view of the target knee will also be obtained during screening to permit evaluation of","text_display":" view of the target knee will also be obtained during screening to permit evaluation of","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[245,1491],[492,1491],[492,1543],[245,1543]],"region":{"top_left_x":244,"top_left_y":1491,"width":248,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80bdd33b7a08431199fa493151b16c78","type":"text","conversion_output":true,"text":"malalignment.","text_display":" malalignment.","confidence":1,"confidence_rate":1},{"cnt":[[245,1581],[806,1581],[806,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1581,"width":562,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da21c93c87eb4808ac82df9ce56a8c59","type":"text","conversion_output":true,"text":"Details are provided in the MOP.","text_display":"\n\nDetails are provided in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[241,1667],[660,1667],[660,1729],[241,1729]],"region":{"top_left_x":240,"top_left_y":1667,"width":420,"height":63},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8eb6799a1054d2892c8d7be4df0713a","type":"section_header","conversion_output":false,"children_ids":["d467db918d21401e8d105f59e7194557"],"text":"","text_display":""},{"cnt":[[245,1671],[655,1671],[655,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1671,"width":412,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d467db918d21401e8d105f59e7194557","type":"text","conversion_output":true,"parent_id":"a8eb6799a1054d2892c8d7be4df0713a","text":"X-Ray Image Analysis","text_display":"\n\n\\section*{X-Ray Image Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[245,1762],[741,1762],[741,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1761,"width":498,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41702fd6770645129e74aea0611cdfa6","type":"text","conversion_output":true,"text":"X-rays will be read centrally.","text_display":"\n\nX-rays will be read centrally.","confidence":0.99951171875,"confidence_rate":0.9999860457974148},{"cnt":[[245,1850],[1880,1850],[1880,1901],[245,1901]],"region":{"top_left_x":244,"top_left_y":1849,"width":1636,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b17f75bf3be404a82561044bf4485ff","type":"text","conversion_output":true,"text":"X-ray images will be used to measure JSW in the medial and lateral femorotibial compartments","text_display":"\nX-ray images will be used to measure JSW in the medial and lateral femorotibial compartments","confidence":1,"confidence_rate":1},{"cnt":[[245,1899],[1347,1899],[1347,1949],[245,1949]],"region":{"top_left_x":244,"top_left_y":1899,"width":1104,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bf33283395f4227b699801b3b4e09e4","type":"text","conversion_output":true,"text":"and to determine the subject's baseline Kellgren-Lawrence grade.","text_display":" and to determine the subject's baseline Kellgren-Lawrence grade.","confidence":1,"confidence_rate":1},{"cnt":[[241,1983],[849,1983],[849,2043],[241,2043]],"region":{"top_left_x":240,"top_left_y":1983,"width":609,"height":61},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6de4da1a01354d2ab81bf599c4f33020","type":"section_header","conversion_output":false,"children_ids":["2d896cf962274dac91c1a7c8ca07b881"],"text":"","text_display":""},{"cnt":[[245,1989],[844,1989],[844,2039],[245,2039]],"region":{"top_left_x":244,"top_left_y":1989,"width":601,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d896cf962274dac91c1a7c8ca07b881","type":"text","conversion_output":true,"parent_id":"6de4da1a01354d2ab81bf599c4f33020","text":"Measurement of Joint Space Width","text_display":"\n\n\\section*{Measurement of Joint Space Width}","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1880,2075],[1880,2127],[245,2127]],"region":{"top_left_x":244,"top_left_y":2075,"width":1636,"height":52},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63991f6f49a84d6eb9b6e057128e70a3","type":"text","conversion_output":true,"text":"Change in JSW as measured by X-ray is a recognized endpoint accepted by the European","text_display":"\n\nChange in JSW as measured by X-ray is a recognized endpoint accepted by the European","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[245,2125],[1880,2125],[1880,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2124,"width":1636,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b3bd862a04842b0bb41728f818b3fab","type":"text","conversion_output":true,"text":"Medicines Agency (EMA) and the United States Food and Drug Administration (FDA) for use in","text_display":" Medicines Agency (EMA) and the United States Food and Drug Administration (FDA) for use in","confidence":1,"confidence_rate":1},{"cnt":[[245,2174],[604,2174],[604,2224],[245,2224]],"region":{"top_left_x":244,"top_left_y":2174,"width":360,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e851966c998d412785f8d9c57dde9021","type":"text","conversion_output":true,"text":"efficacy trials in OA.","text_display":" efficacy trials in OA.","confidence":0.9970715045928955,"confidence_rate":0.9998913839791514},{"cnt":[[245,2264],[1618,2264],[1618,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2264,"width":1374,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb1893f70f09480491e1072f278b0ce6","type":"text","conversion_output":true,"text":"JSW will be measured using standardized technique that is described in the MOP.","text_display":"\n\nJSW will be measured using standardized technique that is described in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c7a81182222a4658a1a80e4f669788c0","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":44},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"60ed6575b4eb4455b35e691c0f6cb3da","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9125548f4d54ecaba5275fa5ebab84e","type":"page_info","conversion_output":false,"text":"70/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-071","page":71,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c077f71b620d4b23841bfa4643d081e9","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"221f3891442749fbbdc19f0d60ee1520","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74e27bfff3c04af0ae9b17a987daf33a","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[724,275],[724,337],[241,337]],"region":{"top_left_x":240,"top_left_y":275,"width":485,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"928210dabb714b1aa2d70e157b848036","type":"section_header","conversion_output":false,"children_ids":["ee5d2d41b4fb4cf3a3865558e869c165"],"text":"","text_display":""},{"cnt":[[245,279],[720,279],[720,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":476,"height":52},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee5d2d41b4fb4cf3a3865558e869c165","type":"text","conversion_output":true,"parent_id":"928210dabb714b1aa2d70e157b848036","text":"Kellgren-Lawrence Scoring","text_display":"\n\n\\section*{Kellgren-Lawrence Scoring}","confidence":1,"confidence_rate":1},{"cnt":[[245,370],[1880,370],[1880,419],[245,419]],"region":{"top_left_x":244,"top_left_y":369,"width":1636,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"856eefa70dd44cc89c6c51e8a5f6d6ad","type":"text","conversion_output":true,"text":"The Kellgren-Lawrence (K-L) scale (28),(29) assigns severity grades for knee OA based on","text_display":"\n\nThe Kellgren-Lawrence (K-L) scale (28),(29) assigns severity grades for knee OA based on","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1880,417],[1880,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6438c86b04ad4eab997c21eefddda6dd","type":"text","conversion_output":true,"text":"radiological assessment of the femorotibial joint (it is important to note that only the femorotibial","text_display":" radiological assessment of the femorotibial joint (it is important to note that only the femorotibial","confidence":1,"confidence_rate":1},{"cnt":[[243,466],[1354,466],[1354,518],[243,518]],"region":{"top_left_x":242,"top_left_y":466,"width":1112,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6856b36946764722933d7184e29bad8a","type":"text","conversion_output":true,"text":"joint is considered). A number from 0 to 4 is assigned, as follows:","text_display":" joint is considered). A number from 0 to 4 is assigned, as follows:","confidence":1,"confidence_rate":1},{"cnt":[[245,537],[913,537],[913,587],[245,587]],"region":{"top_left_x":244,"top_left_y":537,"width":670,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbe446f3fd7245c69353850c9d939427","type":"text","conversion_output":true,"text":"- Grade 0: No feature of osteoarthritis","text_display":"\n- Grade 0: No feature of osteoarthritis","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1575,610],[1575,664],[245,664]],"region":{"top_left_x":244,"top_left_y":610,"width":1331,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"208757530acb45cea3f1e4b8c7b5c31c","type":"text","conversion_output":true,"text":"- Grade 1: Doubtful narrowing of joint space and possible osteophytic lipping","text_display":"\n- Grade 1: Doubtful narrowing of joint space and possible osteophytic lipping","confidence":1,"confidence_rate":1},{"cnt":[[245,679],[1437,679],[1437,733],[245,733]],"region":{"top_left_x":244,"top_left_y":678,"width":1194,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c36c876e7214f178ec34ef4a4863033","type":"text","conversion_output":true,"text":"- Grade 2: Definite osteophytes and possible narrowing of joint space","text_display":"\n- Grade 2: Definite osteophytes and possible narrowing of joint space","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1880,752],[1880,806],[245,806]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"490b42d8253a47989d6701a5acc2cc83","type":"text","conversion_output":true,"text":"- Grade 3: Moderate multiple osteophytes, definite narrowing of joint space and some sclerosis","text_display":"\n- Grade 3: Moderate multiple osteophytes, definite narrowing of joint space and some sclerosis","confidence":1,"confidence_rate":1},{"cnt":[[294,801],[909,801],[909,853],[294,853]],"region":{"top_left_x":294,"top_left_y":801,"width":615,"height":52},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8efab678a27a4fb3832583b955a1309f","type":"text","conversion_output":true,"text":"and possible deformity of bone ends","text_display":" and possible deformity of bone ends","confidence":1,"confidence_rate":1},{"cnt":[[245,872],[1882,872],[1882,924],[245,924]],"region":{"top_left_x":244,"top_left_y":872,"width":1639,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76b7a4c0c2ca4532a6dedb08983d178f","type":"text","conversion_output":true,"text":"- Grade 4: Large osteophytes, marked narrowing of joint space, severe sclerosis and definite","text_display":"\n- Grade 4: Large osteophytes, marked narrowing of joint space, severe sclerosis and definite","confidence":1,"confidence_rate":1},{"cnt":[[292,920],[692,920],[692,971],[292,971]],"region":{"top_left_x":292,"top_left_y":919,"width":400,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e8c559ed1694dccb688b314b818b8e1","type":"text","conversion_output":true,"text":"deformity of bone ends","text_display":" deformity of bone ends","confidence":1,"confidence_rate":1},{"cnt":[[245,1010],[1549,1010],[1549,1061],[245,1061]],"region":{"top_left_x":244,"top_left_y":1009,"width":1306,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3a440580f5f46bfa4fbd40024b261d9","type":"text","conversion_output":true,"text":"Kellgren-Lawrence scoring will be performed by the trial's imaging provider.","text_display":"\n\nKellgren-Lawrence scoring will be performed by the trial's imaging provider.","confidence":1,"confidence_rate":1},{"cnt":[[241,1096],[1033,1096],[1033,1160],[241,1160]],"region":{"top_left_x":240,"top_left_y":1095,"width":794,"height":66},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b96a8131f862499aaf31a67f41e28372","type":"section_header","conversion_output":false,"children_ids":["38adf0f0865c43e9ac794f465f550980"],"text":"","text_display":""},{"cnt":[[245,1102],[1025,1102],[1025,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1102,"width":781,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38adf0f0865c43e9ac794f465f550980","type":"text","conversion_output":true,"parent_id":"b96a8131f862499aaf31a67f41e28372","text":"7.3.5 20-Meter Walk Test","text_display":"\n\n\\subsection*{7.3.5 20-Meter Walk Test}","confidence":0.99951171875,"confidence_rate":0.9999831587453291},{"cnt":[[245,1197],[1880,1197],[1880,1248],[245,1248]],"region":{"top_left_x":244,"top_left_y":1196,"width":1636,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a07feabaea534d0ab9fa9e513005a332","type":"text","conversion_output":true,"text":"The 20 -meter walk test is an objective test of physical function which consists of measuring the","text_display":"\n\nThe 20 -meter walk test is an objective test of physical function which consists of measuring the","confidence":0.9873046875,"confidence_rate":0.9998783256259844},{"cnt":[[245,1246],[1880,1246],[1880,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1246,"width":1636,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e870e4870296420a80bfc03160017728","type":"text","conversion_output":true,"text":"time needed for the subject to walk 20 meters at a normal pace (30),(31). A stopwatch will be","text_display":" time needed for the subject to walk 20 meters at a normal pace (30),(31). A stopwatch will be","confidence":0.439366996901283,"confidence_rate":0.9918902880200726},{"cnt":[[245,1293],[718,1293],[718,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1293,"width":474,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9e6e085fcf848a68947bb3a642c7e42","type":"text","conversion_output":true,"text":"used for time measurement.","text_display":" used for time measurement.","confidence":1,"confidence_rate":1},{"cnt":[[241,1379],[1044,1379],[1044,1450],[241,1450]],"region":{"top_left_x":240,"top_left_y":1379,"width":805,"height":72},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e14d3da195d640f597d32ec253c5748c","type":"section_header","conversion_output":false,"children_ids":["dfa3558fc0a84e41bbc6fc848f9a7236"],"text":"","text_display":""},{"cnt":[[245,1384],[1038,1384],[1038,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1383,"width":794,"height":63},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfa3558fc0a84e41bbc6fc848f9a7236","type":"text","conversion_output":true,"parent_id":"e14d3da195d640f597d32ec253c5748c","text":"7.4 Assessment of Safety","text_display":"\n\n\\subsection*{7.4 Assessment of Safety}","confidence":0.7646484375,"confidence_rate":0.9904622361390237},{"cnt":[[245,1480],[1880,1480],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1480,"width":1636,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5f19689585b4fa089260115a76db378","type":"text","conversion_output":true,"text":"The safety profile of sprifermin will be assessed through the recording, reporting and analyzing","text_display":"\n\nThe safety profile of sprifermin will be assessed through the recording, reporting and analyzing","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1880,1530],[1880,1579],[245,1579]],"region":{"top_left_x":244,"top_left_y":1529,"width":1636,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96e48926893c40e1a551957618fb45d9","type":"text","conversion_output":true,"text":"of baseline medical conditions, AEs, physical examination findings including vital signs, weight,","text_display":" of baseline medical conditions, AEs, physical examination findings including vital signs, weight,","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1880,1577],[1880,1626],[245,1626]],"region":{"top_left_x":244,"top_left_y":1576,"width":1636,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c26621106894978a38e5050f2bc6c0d","type":"text","conversion_output":true,"text":"laboratory tests, and incidence of surgical interventions in the target knee (including any surgical","text_display":" laboratory tests, and incidence of surgical interventions in the target knee (including any surgical","confidence":1,"confidence_rate":1},{"cnt":[[245,1624],[1605,1624],[1605,1674],[245,1674]],"region":{"top_left_x":244,"top_left_y":1624,"width":1361,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f63f6e2f2c03435594c87bc827ddaed1","type":"text","conversion_output":true,"text":"revision, cartilage removal, operation, or any other type of surgical intervention).","text_display":" revision, cartilage removal, operation, or any other type of surgical intervention).","confidence":0.9970703125,"confidence_rate":0.999967034392425},{"cnt":[[245,1714],[1880,1714],[1880,1764],[245,1764]],"region":{"top_left_x":244,"top_left_y":1714,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1248cbe23d643bb8de2cc45c1730a63","type":"text","conversion_output":true,"text":"Comprehensive assessment of any apparent toxicity experienced by the subject will be","text_display":"\n\nComprehensive assessment of any apparent toxicity experienced by the subject will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1762],[1880,1762],[1880,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1761,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"249165e8e8554f16b51a2219dbff1d88","type":"text","conversion_output":true,"text":"performed throughout the course of the trial, from the time of the subject's signature of informed","text_display":" performed throughout the course of the trial, from the time of the subject's signature of informed","confidence":0.9990234375,"confidence_rate":0.9999905142231668},{"cnt":[[245,1809],[1880,1809],[1880,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1808,"width":1636,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b13cc3f4b6554f50a61b8fce286f3e5f","type":"text","conversion_output":true,"text":"consent. Trial site personnel will report any AE, whether observed by the Investigator or reported","text_display":" consent. Trial site personnel will report any AE, whether observed by the Investigator or reported","confidence":1,"confidence_rate":1},{"cnt":[[245,1856],[1800,1856],[1800,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1856,"width":1557,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9c142bd48f84971bab598a26d5319f5","type":"text","conversion_output":true,"text":"by the subject (see Section 7.4.1.4, \"Methods of Recording and Assessing Adverse Events\").","text_display":" by the subject (see Section 7.4.1.4, \"Methods of Recording and Assessing Adverse Events\").","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1946],[1261,1946],[1261,1998],[245,1998]],"region":{"top_left_x":244,"top_left_y":1946,"width":1018,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8ea18c9c3b84fa48f12dfb031019066","type":"text","conversion_output":true,"text":"The reporting period for AEs is described in Section 7.4.1.3.","text_display":"\n\nThe reporting period for AEs is described in Section 7.4.1.3.","confidence":0.9931640625,"confidence_rate":0.999896074952841},{"cnt":[[241,2032],[932,2032],[932,2095],[241,2095]],"region":{"top_left_x":240,"top_left_y":2032,"width":693,"height":63},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fedec37cf404d3dafb569f462a8f472","type":"section_header","conversion_output":false,"children_ids":["b17846d9ca394e1fbb1fe9b5b03a93ba"],"text":"","text_display":""},{"cnt":[[245,2086],[245,2037],[926,2041],[926,2090]],"region":{"top_left_x":244,"top_left_y":2037,"width":683,"height":54},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b17846d9ca394e1fbb1fe9b5b03a93ba","type":"text","conversion_output":true,"parent_id":"2fedec37cf404d3dafb569f462a8f472","text":"7.4.1 Adverse Events","text_display":"\n\n\\subsection*{7.4.1 Adverse Events}","confidence":1,"confidence_rate":1},{"cnt":[[243,2131],[1154,2131],[1154,2194],[243,2194]],"region":{"top_left_x":242,"top_left_y":2131,"width":912,"height":63},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00130c4e7eb4474d9fd0f3015c937bec","type":"section_header","conversion_output":false,"children_ids":["a3eff48524c147b4b9450c52f6a50551"],"text":"","text_display":""},{"cnt":[[245,2138],[1147,2138],[1147,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2137,"width":904,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3eff48524c147b4b9450c52f6a50551","type":"text","conversion_output":true,"parent_id":"00130c4e7eb4474d9fd0f3015c937bec","text":"7.4.1.1 Adverse Event Definitions","text_display":"\n\n\\subsection*{7.4.1.1 Adverse Event Definitions}","confidence":0.9985356330871582,"confidence_rate":0.999961436529223},{"cnt":[[241,2230],[522,2230],[522,2282],[241,2282]],"region":{"top_left_x":240,"top_left_y":2230,"width":283,"height":52},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38540cf9ce234dcea8f74d04acbfa41d","type":"section_header","conversion_output":false,"children_ids":["fdcf29b2e1384c93971babaa9038bb97"],"text":"","text_display":""},{"cnt":[[245,2234],[518,2234],[518,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2234,"width":274,"height":42},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdcf29b2e1384c93971babaa9038bb97","type":"text","conversion_output":true,"parent_id":"38540cf9ce234dcea8f74d04acbfa41d","text":"Adverse Event","text_display":"\n\n\\section*{Adverse Event}","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1880,2320],[1880,2374],[245,2374]],"region":{"top_left_x":244,"top_left_y":2320,"width":1636,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"239c4ca6d3ab4452be526fbd6003eb42","type":"text","conversion_output":true,"text":"An adverse event (AE) is any untoward medical occurrence in a subject or clinical investigation","text_display":"\n\nAn adverse event (AE) is any untoward medical occurrence in a subject or clinical investigation","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,2368],[1880,2365],[1880,2419],[245,2421]],"region":{"top_left_x":244,"top_left_y":2365,"width":1636,"height":57},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e94ffe37ca648c2b0d78037cddb3911","type":"text","conversion_output":true,"text":"subject administered a pharmaceutical product, which does not necessarily have a causal","text_display":" subject administered a pharmaceutical product, which does not necessarily have a causal","confidence":1,"confidence_rate":1},{"cnt":[[245,2419],[1880,2419],[1880,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2419,"width":1636,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fefe2de8f9cc4160aa8a77d4c0f49e1d","type":"text","conversion_output":true,"text":"relationship with this treatment. An AE can therefore be any unfavorable and unintended sign","text_display":" relationship with this treatment. An AE can therefore be any unfavorable and unintended sign","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ae4e51859ba4483baf6ab70001e4c99b","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ab30fd49dc3b494785ccd289594afffa","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73a8bfc25a444f9682c80b0256ce2e6c","type":"page_info","conversion_output":false,"text":"71/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-072","page":72,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e03fbb494e234aa687f797c0855287d8","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99e4a1047176499fb420c6784710d934","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0162fa2ad92444769b7c14130bc0ecd7","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fa3a886a5be4804bc55d56874f0e169","type":"text","conversion_output":true,"text":"(including an abnormal laboratory finding), symptom, or disease temporally associated with the","text_display":"\n(including an abnormal laboratory finding), symptom, or disease temporally associated with the","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1704,329],[1704,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1460,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4a8b7bc051a4241b867509ce4a48613","type":"text","conversion_output":true,"text":"use of a medicinal product, whether or not considered related to the medicinal product.","text_display":" use of a medicinal product, whether or not considered related to the medicinal product.","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1882,417],[1882,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1639,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"511c02eaee704f99a0c8d62cf028cef1","type":"text","conversion_output":true,"text":"In cases of surgical or diagnostic procedures, the condition/illness leading to such a procedure is","text_display":"\n\nIn cases of surgical or diagnostic procedures, the condition/illness leading to such a procedure is","confidence":1,"confidence_rate":1},{"cnt":[[245,466],[1141,466],[1141,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":897,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57b072255bb544da93ff0b893413b6c6","type":"text","conversion_output":true,"text":"considered as the AE rather than the procedure itself.","text_display":" considered as the AE rather than the procedure itself.","confidence":0.99462890625,"confidence_rate":0.9999087233196545},{"cnt":[[245,554],[1882,554],[1882,608],[245,608]],"region":{"top_left_x":244,"top_left_y":554,"width":1639,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95ac1aff678d4b298d6d3cff1891e896","type":"text","conversion_output":true,"text":"In case of a fatality, the cause of death is considered as the AE, and the death is considered as its","text_display":"\n\nIn case of a fatality, the cause of death is considered as the AE, and the death is considered as its","confidence":0.9658203125,"confidence_rate":0.999671964438295},{"cnt":[[245,602],[471,602],[471,651],[245,651]],"region":{"top_left_x":244,"top_left_y":601,"width":227,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb10f69d11bb46aeb1b0e509bcb37d88","type":"text","conversion_output":true,"text":"OUTCOME.","text_display":" OUTCOME.","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1274,692],[1274,746],[245,746]],"region":{"top_left_x":244,"top_left_y":691,"width":1031,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e479ac02054e4eeb874d33c29fa6820e","type":"text","conversion_output":true,"text":"The Investigator is required to grade the severity of each AE.","text_display":"\n\nThe Investigator is required to grade the severity of each AE.","confidence":0.98193359375,"confidence_rate":0.9997279236405809},{"cnt":[[245,782],[1882,782],[1882,836],[245,836]],"region":{"top_left_x":244,"top_left_y":782,"width":1639,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc0e964fd51940498bbd5abecf2a4050","type":"text","conversion_output":true,"text":"Investigators must assess the severity of AEs according to the Qualitative Toxicity Scale, as","text_display":"\nInvestigators must assess the severity of AEs according to the Qualitative Toxicity Scale, as","confidence":1,"confidence_rate":1},{"cnt":[[245,829],[391,829],[391,879],[245,879]],"region":{"top_left_x":244,"top_left_y":829,"width":148,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2a7d27d6e4a407a860a34fc1d591a88","type":"text","conversion_output":true,"text":"follows:","text_display":" follows:","confidence":1,"confidence_rate":1},{"cnt":[[245,917],[1882,917],[1882,973],[245,973]],"region":{"top_left_x":244,"top_left_y":917,"width":1639,"height":57},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c6804fd79ba4e09b771f222a604f033","type":"text","conversion_output":true,"text":"Mild: The subject is aware of the event or symptom, but the event or symptom is easily","text_display":"\n\nMild: The subject is aware of the event or symptom, but the event or symptom is easily","confidence":1,"confidence_rate":1},{"cnt":[[490,969],[655,969],[655,1016],[490,1016]],"region":{"top_left_x":489,"top_left_y":968,"width":167,"height":49},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f960d5e43ad94578bce98a681ad7c19d","type":"text","conversion_output":true,"text":"tolerated.","text_display":" tolerated.","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1882,1053],[1882,1111],[245,1111]],"region":{"top_left_x":244,"top_left_y":1052,"width":1639,"height":59},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7936c9092c084057ac033baaca63b8d4","type":"text","conversion_output":true,"text":"Moderate: The subject experiences sufficient discomfort to interfere with or reduce his or her","text_display":"\n\nModerate: The subject experiences sufficient discomfort to interfere with or reduce his or her","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[490,1104],[870,1104],[870,1158],[490,1158]],"region":{"top_left_x":489,"top_left_y":1104,"width":382,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f04d5a6fc45481c9053d825769eb0ae","type":"text","conversion_output":true,"text":"usual level of activity.","text_display":" usual level of activity.","confidence":1,"confidence_rate":1},{"cnt":[[245,1190],[1882,1190],[1882,1248],[245,1248]],"region":{"top_left_x":244,"top_left_y":1190,"width":1639,"height":59},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44ad63560af947a7b350d993271483d3","type":"text","conversion_output":true,"text":"Severe: Significant impairment of functioning: the subject is unable to carry out usual","text_display":"\n\nSevere: Significant impairment of functioning: the subject is unable to carry out usual","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[490,1242],[660,1242],[660,1291],[490,1291]],"region":{"top_left_x":489,"top_left_y":1241,"width":171,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07c69d5cac814c5fa3ba0eceec46185b","type":"text","conversion_output":true,"text":"activities.","text_display":" activities.","confidence":1,"confidence_rate":1},{"cnt":[[245,1332],[1882,1332],[1882,1386],[245,1386]],"region":{"top_left_x":244,"top_left_y":1332,"width":1639,"height":54},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65d29cb3cc2040c4b0033d194d014957","type":"text","conversion_output":true,"text":"Investigators must also systematically assess the causal relationship of AEs to the IMP using the","text_display":"\n\nInvestigators must also systematically assess the causal relationship of AEs to the IMP using the","confidence":1,"confidence_rate":1},{"cnt":[[245,1379],[1880,1379],[1880,1433],[245,1433]],"region":{"top_left_x":244,"top_left_y":1379,"width":1636,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccc5fa7efcc94255af2138f76a609f3c","type":"text","conversion_output":true,"text":"following definitions. Decisive factors for the assessment of causal relationship of an AE to the","text_display":" following definitions. Decisive factors for the assessment of causal relationship of an AE to the","confidence":1,"confidence_rate":1},{"cnt":[[245,1427],[1880,1427],[1880,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1426,"width":1636,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8564d955b65b42748a4b4a5b64076569","type":"text","conversion_output":true,"text":"IMP include, but may not be limited to, temporal relationship between the AE and the IMP,","text_display":" IMP include, but may not be limited to, temporal relationship between the AE and the IMP,","confidence":0.978515625,"confidence_rate":0.9997689785623859},{"cnt":[[245,1474],[1882,1474],[1882,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1473,"width":1639,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd2b46965dda4e109d1e1691404e794e","type":"text","conversion_output":true,"text":"known side effects of the IMP, medical history, concomitant medication, course of the","text_display":" known side effects of the IMP, medical history, concomitant medication, course of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1523],[926,1523],[926,1577],[245,1577]],"region":{"top_left_x":244,"top_left_y":1523,"width":682,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7149051ad94424e8bb3c5908e9af2f4","type":"text","conversion_output":true,"text":"underlying disease, and trial procedures.","text_display":" underlying disease, and trial procedures.","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1882,1611],[1882,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1611,"width":1639,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41d4c70ee02a4be89516c70fe1ed915b","type":"text","conversion_output":true,"text":"Not related: Not suspected to be reasonably related to the IMP. AE could not medically","text_display":"\n\nNot related: Not suspected to be reasonably related to the IMP. AE could not medically","confidence":1,"confidence_rate":1},{"cnt":[[490,1661],[1882,1661],[1882,1712],[490,1712]],"region":{"top_left_x":489,"top_left_y":1660,"width":1394,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"445ef6c763c54a8f9e780adbe55e1d2d","type":"text","conversion_output":true,"text":"(pharmacologically/clinically) be attributed to the IMP under study in this clinical","text_display":" (pharmacologically/clinically) be attributed to the IMP under study in this clinical","confidence":1,"confidence_rate":1},{"cnt":[[490,1710],[1661,1710],[1661,1762],[490,1762]],"region":{"top_left_x":489,"top_left_y":1710,"width":1172,"height":52},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0faeb401cf6b44aca6c86c490ed3bc79","type":"text","conversion_output":true,"text":"trial protocol. A reasonable alternative explanation must be available.","text_display":" trial protocol. A reasonable alternative explanation must be available.","confidence":0.99951171875,"confidence_rate":0.9999935736983052},{"cnt":[[245,1796],[1882,1796],[1882,1850],[245,1850]],"region":{"top_left_x":244,"top_left_y":1796,"width":1639,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cebcff6a642249fbabe7fe1b30e315b8","type":"text","conversion_output":true,"text":"Related: Suspected to be reasonably related to the IMP. AE could medically","text_display":"\n\nRelated: Suspected to be reasonably related to the IMP. AE could medically","confidence":1,"confidence_rate":1},{"cnt":[[490,1848],[1882,1848],[1882,1901],[490,1901]],"region":{"top_left_x":489,"top_left_y":1847,"width":1394,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6edab693591c402982d3ae3f0a8cc98e","type":"text","conversion_output":true,"text":"(pharmacologically/clinically) be attributed to the IMP under study in this clinical","text_display":" (pharmacologically/clinically) be attributed to the IMP under study in this clinical","confidence":1,"confidence_rate":1},{"cnt":[[490,1895],[728,1895],[728,1949],[490,1949]],"region":{"top_left_x":489,"top_left_y":1894,"width":240,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c5a10971a9a444090eb5d6f3b011f0d","type":"text","conversion_output":true,"text":"trial protocol.","text_display":" trial protocol.","confidence":1,"confidence_rate":1},{"cnt":[[241,1981],[1652,1981],[1652,2043],[241,2043]],"region":{"top_left_x":240,"top_left_y":1980,"width":1413,"height":64},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85583cf08cf14f2f9f80cbab9759d795","type":"section_header","conversion_output":false,"children_ids":["f32440b9218f4af9b44b010290d8a957"],"text":"","text_display":""},{"cnt":[[245,1985],[1648,1985],[1648,2039],[245,2039]],"region":{"top_left_x":244,"top_left_y":1985,"width":1404,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f32440b9218f4af9b44b010290d8a957","type":"text","conversion_output":true,"parent_id":"85583cf08cf14f2f9f80cbab9759d795","text":"Abnormal Laboratory Findings and Other Abnormal Investigational Findings","text_display":"\n\n\\section*{Abnormal Laboratory Findings and Other Abnormal Investigational Findings}","confidence":1,"confidence_rate":1},{"cnt":[[245,2073],[1880,2073],[1880,2125],[245,2125]],"region":{"top_left_x":244,"top_left_y":2073,"width":1636,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89e4b5bafe1344388978f91e88985a7b","type":"text","conversion_output":true,"text":"Abnormal laboratory findings and other abnormal investigational findings (e.g., on an ECG","text_display":"\n\nAbnormal laboratory findings and other abnormal investigational findings (e.g., on an ECG","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,2123],[1880,2123],[1880,2174],[245,2174]],"region":{"top_left_x":244,"top_left_y":2122,"width":1636,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c6b2fc6dc3b427ab3b5e65cef48b9fb","type":"text","conversion_output":true,"text":"trace) should not be reported as AEs unless they are associated with clinical signs and symptoms,","text_display":" trace) should not be reported as AEs unless they are associated with clinical signs and symptoms,","confidence":1,"confidence_rate":1},{"cnt":[[245,2170],[1880,2170],[1880,2221],[245,2221]],"region":{"top_left_x":244,"top_left_y":2169,"width":1636,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f3051f9417c44c1bb266ae57603e0e5","type":"text","conversion_output":true,"text":"lead to treatment discontinuation or are considered otherwise medically important by the","text_display":" lead to treatment discontinuation or are considered otherwise medically important by the","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,2217],[1880,2217],[1880,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2217,"width":1636,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9007c1b84b1a4bf0bc58c9a170673a9a","type":"text","conversion_output":true,"text":"Investigator. If an abnormality fulfills these criteria, the identified medical condition (e.g.,","text_display":" Investigator. If an abnormality fulfills these criteria, the identified medical condition (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[245,2264],[1745,2264],[1745,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2264,"width":1501,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8ec27622b74420a891fcc5b70d3735e","type":"text","conversion_output":true,"text":"anemia, increased ALT) must be reported as the AE rather than the abnormal value itself.","text_display":" anemia, increased ALT) must be reported as the AE rather than the abnormal value itself.","confidence":0.99853515625,"confidence_rate":0.9999842375685026},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":37,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2b4a09306e394efab889d10ef9c94a4c","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[389,2544],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":145,"height":46},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8f3583764a1a476782f199e5c0778229","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51d02bdef1834a1cb7b0f759fdc2c69b","type":"page_info","conversion_output":false,"text":"72/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-073","page":73,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ce68e3e6fd94b4f8ba2555d7807cbd3","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2898c353dbf455e9447d156a4ee5a4a","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2532fd7d721463f92e8a2cd63eb2ce8","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,277],[664,277],[664,331],[241,331]],"region":{"top_left_x":240,"top_left_y":277,"width":424,"height":54},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21a02640d56e47b2888d0392527bddca","type":"section_header","conversion_output":false,"children_ids":["fccee512deac45dab9ad93ba88975218"],"text":"","text_display":""},{"cnt":[[245,284],[660,284],[660,324],[245,324]],"region":{"top_left_x":244,"top_left_y":283,"width":416,"height":42},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fccee512deac45dab9ad93ba88975218","type":"text","conversion_output":true,"parent_id":"21a02640d56e47b2888d0392527bddca","text":"Serious Adverse Event","text_display":"\n\n\\section*{Serious Adverse Event}","confidence":1,"confidence_rate":1},{"cnt":[[245,370],[1663,370],[1663,421],[245,421]],"region":{"top_left_x":244,"top_left_y":369,"width":1419,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ae214af5bfe4e84a3e50800c1a90397","type":"text","conversion_output":true,"text":"A serious adverse event (SAE) is any untoward medical occurrence that at any dose:","text_display":"\n\nA serious adverse event (SAE) is any untoward medical occurrence that at any dose:","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[245,443],[580,443],[580,488],[245,488]],"region":{"top_left_x":244,"top_left_y":442,"width":337,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96ec36ab7a7b422593fb5a93771af167","type":"text","conversion_output":true,"text":"- Results in death.","text_display":"\n- Results in death.","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[612,511],[612,565],[245,565]],"region":{"top_left_x":244,"top_left_y":511,"width":369,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b65769859c5c4c2e89becd318e43271d","type":"text","conversion_output":true,"text":"- Is life-threatening.","text_display":"\n- Is life-threatening.","confidence":1,"confidence_rate":1},{"cnt":[[292,580],[1880,580],[1880,634],[292,634]],"region":{"top_left_x":292,"top_left_y":580,"width":1588,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70cfd5a6009b49d38439fcd7bfc560da","type":"text","conversion_output":true,"text":"NOTE: The term \"life-threatening\" in this definition refers to an event in which the subject is","text_display":"\n\nNOTE: The term \"life-threatening\" in this definition refers to an event in which the subject is","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[292,629],[1882,629],[1882,681],[292,681]],"region":{"top_left_x":292,"top_left_y":629,"width":1591,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7501225e9fd4b02b8d0a93e3458f34e","type":"text","conversion_output":true,"text":"at risk of death at the time of the event; it does not refer to an event that hypothetically might","text_display":" at risk of death at the time of the event; it does not refer to an event that hypothetically might","confidence":1,"confidence_rate":1},{"cnt":[[292,679],[879,679],[879,724],[292,724]],"region":{"top_left_x":292,"top_left_y":678,"width":587,"height":47},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bb3d7b9517d4829a30d42fa551e520c","type":"text","conversion_output":true,"text":"cause death if it were more severe.","text_display":" cause death if it were more severe.","confidence":1,"confidence_rate":1},{"cnt":[[245,750],[1588,750],[1588,801],[245,801]],"region":{"top_left_x":244,"top_left_y":749,"width":1344,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36b7f03328eb4130b394aa8b9cc93702","type":"text","conversion_output":true,"text":"- Requires inpatient hospitalization or prolongation of existing hospitalization.","text_display":"\n- Requires inpatient hospitalization or prolongation of existing hospitalization.","confidence":0.99853515625,"confidence_rate":0.999982954590827},{"cnt":[[245,821],[1229,821],[1229,874],[245,874]],"region":{"top_left_x":244,"top_left_y":820,"width":985,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4679eb5819f64effbfd4f29e65eaf319","type":"text","conversion_output":true,"text":"- Results in persistent or significant disability/incapacity.","text_display":"\n- Results in persistent or significant disability/incapacity.","confidence":1,"confidence_rate":1},{"cnt":[[245,894],[913,894],[913,947],[245,947]],"region":{"top_left_x":244,"top_left_y":893,"width":670,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5341dfa36e54838b2a8ea9fa6a2664e","type":"text","conversion_output":true,"text":"- Is a congenital anomaly/birth defect.","text_display":"\n- Is a congenital anomaly/birth defect.","confidence":1,"confidence_rate":1},{"cnt":[[245,965],[1098,965],[1098,1016],[245,1016]],"region":{"top_left_x":244,"top_left_y":964,"width":854,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4ff9227387749d48762fb0d404b50d5","type":"text","conversion_output":true,"text":"- Is otherwise considered as medically important.","text_display":"\n- Is otherwise considered as medically important.","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1882,1053],[1882,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1052,"width":1639,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bf7128129ed4e5fbc10d1e4227dbdca","type":"text","conversion_output":true,"text":"Important medical events that may not result in death, be life-threatening, or require","text_display":"\n\nImportant medical events that may not result in death, be life-threatening, or require","confidence":1,"confidence_rate":1},{"cnt":[[245,1104],[1880,1104],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1104,"width":1636,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c956ce903214d259d0421c97f27fd08","type":"text","conversion_output":true,"text":"hospitalization may be considered as SAEs when, based upon appropriate medical judgment,","text_display":" hospitalization may be considered as SAEs when, based upon appropriate medical judgment,","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1884,1147],[1884,1201],[245,1201]],"region":{"top_left_x":244,"top_left_y":1147,"width":1641,"height":54},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4ea9ec64f8c4c6f81b807e7f033bbc3","type":"text","conversion_output":true,"text":"they may jeopardize the subject or may require medical or surgical intervention to prevent one of","text_display":" they may jeopardize the subject or may require medical or surgical intervention to prevent one of","confidence":1,"confidence_rate":1},{"cnt":[[245,1199],[1882,1199],[1882,1248],[245,1248]],"region":{"top_left_x":244,"top_left_y":1198,"width":1639,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a118b96745c4cd3bb1be7c9268805d1","type":"text","conversion_output":true,"text":"the outcomes listed in this definition. Examples of such events include allergic bronchospasm","text_display":" the outcomes listed in this definition. Examples of such events include allergic bronchospasm","confidence":1,"confidence_rate":1},{"cnt":[[245,1246],[1880,1246],[1880,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1246,"width":1636,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be4e058f46464903aec0304c086a5cc3","type":"text","conversion_output":true,"text":"requiring intensive treatment in an emergency room or at home, blood dyscrasias or convulsions","text_display":" requiring intensive treatment in an emergency room or at home, blood dyscrasias or convulsions","confidence":1,"confidence_rate":1},{"cnt":[[245,1293],[1882,1293],[1882,1347],[245,1347]],"region":{"top_left_x":244,"top_left_y":1293,"width":1639,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"269d74826e4c4531ab92b8de2e6dfb4e","type":"text","conversion_output":true,"text":"that do not result in inpatient hospitalization, or the development of drug dependency or drug","text_display":" that do not result in inpatient hospitalization, or the development of drug dependency or drug","confidence":1,"confidence_rate":1},{"cnt":[[245,1345],[359,1345],[359,1388],[245,1388]],"region":{"top_left_x":244,"top_left_y":1344,"width":115,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aab5de8b6d874adeb4eb6419ee5ba7cb","type":"text","conversion_output":true,"text":"abuse.","text_display":" abuse.","confidence":1,"confidence_rate":1},{"cnt":[[245,1431],[1880,1431],[1880,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1430,"width":1636,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1ee8abd492c497eb3099fee0a5dc78f","type":"text","conversion_output":true,"text":"For the purposes of reporting, any suspected transmission of an infectious agent via an IMP is","text_display":"\n\nFor the purposes of reporting, any suspected transmission of an infectious agent via an IMP is","confidence":0.998046875,"confidence_rate":0.9999802523683627},{"cnt":[[245,1478],[1880,1478],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1478,"width":1636,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6e83fde400740ccb5c88b641635a119","type":"text","conversion_output":true,"text":"also considered a serious adverse reaction and all such cases should be reported in an expedited","text_display":" also considered a serious adverse reaction and all such cases should be reported in an expedited","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[907,1525],[907,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1525,"width":663,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8aea81748fe4bdaab03fa18a6697396","type":"text","conversion_output":true,"text":"manner as described in Section 7.4.1.4.","text_display":" manner as described in Section 7.4.1.4.","confidence":1,"confidence_rate":1},{"cnt":[[241,1611],[1145,1611],[1145,1669],[241,1669]],"region":{"top_left_x":240,"top_left_y":1611,"width":906,"height":59},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f31b6d8e0d349f386a4a213b6bb9876","type":"section_header","conversion_output":false,"children_ids":["cbc4aeaa526341f8bb4a96a80a469cf7"],"text":"","text_display":""},{"cnt":[[245,1618],[1141,1616],[1141,1663],[245,1665]],"region":{"top_left_x":244,"top_left_y":1615,"width":897,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbc4aeaa526341f8bb4a96a80a469cf7","type":"text","conversion_output":true,"parent_id":"7f31b6d8e0d349f386a4a213b6bb9876","text":"Events that Do Not Meet the Definition of an SAE","text_display":"\n\n\\section*{Events that Do Not Meet the Definition of an SAE}","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1880,1706],[1880,1757],[245,1757]],"region":{"top_left_x":244,"top_left_y":1705,"width":1636,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cef1e65508554f23bc0db489da56e41d","type":"text","conversion_output":true,"text":"Elective hospitalizations to administer, or to simplify trial treatment or trial procedures (e.g., an","text_display":"\n\nElective hospitalizations to administer, or to simplify trial treatment or trial procedures (e.g., an","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[1880,1753],[1880,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1753,"width":1636,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54507d120bf14dba98f99df47b7871d3","type":"text","conversion_output":true,"text":"overnight stay to facilitate chemotherapy and related hydration therapy application) are not","text_display":" overnight stay to facilitate chemotherapy and related hydration therapy application) are not","confidence":1,"confidence_rate":1},{"cnt":[[245,1800],[1880,1800],[1880,1854],[245,1854]],"region":{"top_left_x":244,"top_left_y":1800,"width":1636,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59fdf1b7ec564251a187fb1ded9f8ee4","type":"text","conversion_output":true,"text":"considered as SAEs. However, all events leading to unplanned hospitalizations or unplanned","text_display":" considered as SAEs. However, all events leading to unplanned hospitalizations or unplanned","confidence":1,"confidence_rate":1},{"cnt":[[245,1850],[1882,1850],[1882,1901],[245,1901]],"region":{"top_left_x":244,"top_left_y":1849,"width":1639,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd646986e640444caef22074292a20e4","type":"text","conversion_output":true,"text":"prolongation of an elective hospitalization (e.g., undesirable effects of any administered","text_display":" prolongation of an elective hospitalization (e.g., undesirable effects of any administered","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1899],[1162,1899],[1162,1949],[245,1949]],"region":{"top_left_x":244,"top_left_y":1899,"width":919,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10c1d6f2ea044428a655a4c3296f0826","type":"text","conversion_output":true,"text":"treatment) must be documented and reported as SAEs.","text_display":" treatment) must be documented and reported as SAEs.","confidence":1,"confidence_rate":1},{"cnt":[[245,1989],[1880,1989],[1880,2039],[245,2039]],"region":{"top_left_x":244,"top_left_y":1989,"width":1636,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0eb99925af24384a4d9c0b2d3dafb4b","type":"text","conversion_output":true,"text":"Medical conditions present at the initial trial visit that do not worsen in severity or frequency","text_display":"\n\nMedical conditions present at the initial trial visit that do not worsen in severity or frequency","confidence":1,"confidence_rate":1},{"cnt":[[245,2037],[1852,2037],[1852,2086],[245,2086]],"region":{"top_left_x":244,"top_left_y":2036,"width":1608,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e9d6b5a62f244b68145f4bb473b5476","type":"text","conversion_output":true,"text":"during the trial are defined as Baseline Medical Conditions, and are NOT to be considered AEs.","text_display":" during the trial are defined as Baseline Medical Conditions, and are NOT to be considered AEs.","confidence":1,"confidence_rate":1},{"cnt":[[245,2125],[1880,2125],[1880,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2124,"width":1636,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de5cd1ad46c4469db76ea21e29f204e9","type":"text","conversion_output":true,"text":"Progression of underlying disease is not an AE and therefore not an SAE per se, rather an","text_display":"\n\nProgression of underlying disease is not an AE and therefore not an SAE per se, rather an","confidence":1,"confidence_rate":1},{"cnt":[[245,2174],[1562,2174],[1562,2224],[245,2224]],"region":{"top_left_x":244,"top_left_y":2174,"width":1318,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b628a5c0cd884e03b33075a180d09b97","type":"text","conversion_output":true,"text":"efficacy endpoint, unless deemed to be causally related to IMP administration.","text_display":" efficacy endpoint, unless deemed to be causally related to IMP administration.","confidence":1,"confidence_rate":1},{"cnt":[[241,2258],[1287,2258],[1287,2322],[241,2322]],"region":{"top_left_x":240,"top_left_y":2258,"width":1047,"height":65},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e185fd626c4f491793bd6b2ffa544ce2","type":"section_header","conversion_output":false,"children_ids":["d889bc3c81d043a0b18c190767cbd8cd"],"text":"","text_display":""},{"cnt":[[245,2264],[1280,2264],[1280,2316],[245,2316]],"region":{"top_left_x":244,"top_left_y":2264,"width":1037,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d889bc3c81d043a0b18c190767cbd8cd","type":"text","conversion_output":true,"parent_id":"e185fd626c4f491793bd6b2ffa544ce2","text":"Pre-defined AEs of Special Interest for Safety Monitoring","text_display":"\n\n\\section*{Pre-defined AEs of Special Interest for Safety Monitoring}","confidence":1,"confidence_rate":1},{"cnt":[[245,2350],[1880,2350],[1880,2404],[245,2404]],"region":{"top_left_x":244,"top_left_y":2350,"width":1636,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dd5333d58fb4f3c98f6ebf8d29446c5","type":"text","conversion_output":true,"text":"One of the trial's safety endpoints is the incidence of AIRs, defined as increase of pain by 30 mm","text_display":"\n\nOne of the trial's safety endpoints is the incidence of AIRs, defined as increase of pain by 30 mm","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,2402],[1880,2402],[1880,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1636,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"487b51e87a464575a31deeec896be158","type":"text","conversion_output":true,"text":"on a \\(100- mm\\) VAS and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days","text_display":" on a \\(100- mm\\) VAS and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days","confidence":0.996584415435791,"confidence_rate":0.9999688965656346},{"cnt":[[245,2449],[642,2449],[642,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2449,"width":399,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c332cbda99f447b8716eda7bcf41e0a","type":"text","conversion_output":true,"text":"following i.a. injection.","text_display":" following i.a. injection.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a3b1e62848d145369e514f18ecec3cfc","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2544],[390,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2543,"width":146,"height":45},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"37f6f1f9f5774eb2a13962a9a941a5da","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b131b1b76cb04e4d8d996a53a08cccff","type":"page_info","conversion_output":false,"text":"73/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-074","page":74,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5acf2de2dc0e45d68c2d5401188cc334","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7aa5ffb4b5240bdb4c1bb392d6311b8","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96ede871f06643b5b8345ff460b568fb","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e78087c3586940f4ad98322a99c4a4c5","type":"text","conversion_output":true,"text":"It is recognized that events meeting this definition will not be necessarily drug-related or","text_display":"\n\nIt is recognized that events meeting this definition will not be necessarily drug-related or","confidence":0.9990234375,"confidence_rate":0.9999899274770393},{"cnt":[[245,329],[1882,329],[1882,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1639,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a63d482bbaa2439485a731a76b0b4373","type":"text","conversion_output":true,"text":"inflammatory in nature; however, it is believed that the definition will permit capture of most","text_display":" inflammatory in nature; however, it is believed that the definition will permit capture of most","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1880,374],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e61c2da23b63400880687085dbb67dd3","type":"text","conversion_output":true,"text":"clinically relevant local reactions. A similar definition based on a \\(30- mm\\) increase in pain and","text_display":" clinically relevant local reactions. A similar definition based on a \\(30- mm\\) increase in pain and","confidence":1,"confidence_rate":1},{"cnt":[[245,421],[1878,421],[1878,475],[245,475]],"region":{"top_left_x":244,"top_left_y":421,"width":1634,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffe9e66a7b114cd1bbb7b63174f7867f","type":"text","conversion_output":true,"text":"local swelling was used in a trial in rheumatoid arthritis involving i.a. injections of interleukin- 1","text_display":" local swelling was used in a trial in rheumatoid arthritis involving i.a. injections of interleukin- 1","confidence":0.90283203125,"confidence_rate":0.999036136939492},{"cnt":[[245,473],[973,473],[973,524],[245,524]],"region":{"top_left_x":244,"top_left_y":472,"width":730,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3266c9c4da6b40b29740802fc0e683e9","type":"text","conversion_output":true,"text":"receptor antagonist (IL-1ra; anakinra (23)).","text_display":" receptor antagonist (IL-1ra; anakinra (23)).","confidence":1,"confidence_rate":1},{"cnt":[[243,559],[1882,559],[1882,612],[243,612]],"region":{"top_left_x":242,"top_left_y":558,"width":1641,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3798fac2459c489599a8421892fe1717","type":"text","conversion_output":true,"text":"At each visit, subjects will be given trial diaries for recording of any AEs occurring or","text_display":"\n\nAt each visit, subjects will be given trial diaries for recording of any AEs occurring or","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1880,610],[1880,660],[245,660]],"region":{"top_left_x":244,"top_left_y":610,"width":1636,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82233ccfbff447a889d98cbf63f6b177","type":"text","conversion_output":true,"text":"concomitant medications used between visits. These diaries will also be used to record maximum","text_display":" concomitant medications used between visits. These diaries will also be used to record maximum","confidence":1,"confidence_rate":1},{"cnt":[[243,657],[1880,657],[1880,709],[243,709]],"region":{"top_left_x":242,"top_left_y":657,"width":1638,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0703d4c679e49f094336a4bbfc0c243","type":"text","conversion_output":true,"text":"pain (using a \\(100- mm\\) VAS) and presence or absence of joint swelling in the target knee for the","text_display":" pain (using a \\(100- mm\\) VAS) and presence or absence of joint swelling in the target knee for the","confidence":0.9990234375,"confidence_rate":0.9999906949037896},{"cnt":[[245,705],[1424,705],[1424,758],[245,758]],"region":{"top_left_x":244,"top_left_y":704,"width":1181,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e83e51357de5495580f58f732f6dc0c6","type":"text","conversion_output":true,"text":"day before and the 3 days after each IMP injection (see Section 7.1.1).","text_display":" day before and the 3 days after each IMP injection (see Section 7.1.1).","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[1880,795],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":794,"width":1636,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbdc5e4331cb4ab8899c37a90cd387db","type":"text","conversion_output":true,"text":"Completed diaries will be collected and reviewed at each visit, and information will be","text_display":"\n\nCompleted diaries will be collected and reviewed at each visit, and information will be","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[243,842],[1880,842],[1880,896],[243,896]],"region":{"top_left_x":242,"top_left_y":842,"width":1638,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d15d0a2fe14d42ce8ea2de26dd613cbb","type":"text","conversion_output":true,"text":"transcribed to the CRFs following medical review. AIRs will be identified by the Sponsor based","text_display":" transcribed to the CRFs following medical review. AIRs will be identified by the Sponsor based","confidence":1,"confidence_rate":1},{"cnt":[[245,889],[1772,889],[1772,943],[245,943]],"region":{"top_left_x":244,"top_left_y":889,"width":1529,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba184e166cfa4faabbc0b8c9e44f6916","type":"text","conversion_output":true,"text":"on the information about pain and swelling that is transcribed from the diaries to the CRFs.","text_display":" on the information about pain and swelling that is transcribed from the diaries to the CRFs.","confidence":1,"confidence_rate":1},{"cnt":[[236,975],[1708,975],[1708,1046],[236,1046]],"region":{"top_left_x":236,"top_left_y":975,"width":1473,"height":72},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b608cc65b1f4b2894bdb7e47099c64d","type":"section_header","conversion_output":false,"children_ids":["ea0109a17c784bed88ef96a160e98aab"],"text":"","text_display":""},{"cnt":[[245,1041],[245,982],[1699,984],[1699,1043]],"region":{"top_left_x":244,"top_left_y":981,"width":1456,"height":63},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea0109a17c784bed88ef96a160e98aab","type":"text","conversion_output":true,"parent_id":"3b608cc65b1f4b2894bdb7e47099c64d","text":"7.4.1.2 Methods of Recording and Assessing Adverse Events","text_display":"\n\n\\subsection*{7.4.1.2 Methods of Recording and Assessing Adverse Events}","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1880,1079],[1880,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1078,"width":1636,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b72ec342bf3a49f5ad095fe3c5fe85f1","type":"text","conversion_output":true,"text":"At each trial visit, the subject will be queried on changes in his/her condition. During the","text_display":"\n\nAt each trial visit, the subject will be queried on changes in his/her condition. During the","confidence":1,"confidence_rate":1},{"cnt":[[245,1126],[1880,1126],[1880,1177],[245,1177]],"region":{"top_left_x":244,"top_left_y":1125,"width":1636,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4df01ef213f42c88a1460edda8bdff1","type":"text","conversion_output":true,"text":"reporting period of the trial, any unfavorable changes in the subject's condition will be recorded","text_display":" reporting period of the trial, any unfavorable changes in the subject's condition will be recorded","confidence":0.9990234375,"confidence_rate":0.9999905142231666},{"cnt":[[245,1173],[1454,1173],[1454,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1211,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"031c476f15c74884a8bd0463371b7bb3","type":"text","conversion_output":true,"text":"as AEs, whether reported by the subject or observed by the Investigator.","text_display":" as AEs, whether reported by the subject or observed by the Investigator.","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1880,1263],[1880,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1263,"width":1636,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e8c2fa430c442bf86ef5e916e76e841","type":"text","conversion_output":true,"text":"Subjects will be asked to record information about any adverse reactions experienced between","text_display":"\n\nSubjects will be asked to record information about any adverse reactions experienced between","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1880,1311],[1880,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1310,"width":1636,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9efc9487af3447918464ca4e689d9cd8","type":"text","conversion_output":true,"text":"trial visits on their trial diaries (see Section 7.1.1). Diaries will be reviewed at each trial visit;","text_display":" trial visits on their trial diaries (see Section 7.1.1). Diaries will be reviewed at each trial visit;","confidence":1,"confidence_rate":1},{"cnt":[[245,1358],[1880,1358],[1880,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1357,"width":1636,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53dd47f6da8041669e324c7d284ea518","type":"text","conversion_output":true,"text":"information thus collected will be reviewed and assessed medically before it is transcribed to the","text_display":" information thus collected will be reviewed and assessed medically before it is transcribed to the","confidence":1,"confidence_rate":1},{"cnt":[[245,1405],[342,1405],[342,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1405,"width":98,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d4d459abc654252bc3b67c3282f2c3d","type":"text","conversion_output":true,"text":"CRF.","text_display":" CRF.","confidence":1,"confidence_rate":1},{"cnt":[[245,1495],[1880,1495],[1880,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1495,"width":1636,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37a33cb979c141869c3466675dcdf937","type":"text","conversion_output":true,"text":"Complete, accurate and consistent data on all AEs experienced for the duration of the reporting","text_display":"\n\nComplete, accurate and consistent data on all AEs experienced for the duration of the reporting","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1880,1543],[1880,1596],[245,1596]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ede2476cbd342ad83a59889df2caa30","type":"text","conversion_output":true,"text":"period (defined below) will be reported on an ongoing basis in the appropriate section of the","text_display":" period (defined below) will be reported on an ongoing basis in the appropriate section of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1592],[1880,1592],[1880,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1591,"width":1636,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c22159dbbb44bb2b982da3a1cf7dc11","type":"text","conversion_output":true,"text":"CRF. Among these AEs, all serious AEs must be additionally documented and reported using an","text_display":" CRF. Among these AEs, all serious AEs must be additionally documented and reported using an","confidence":1,"confidence_rate":1},{"cnt":[[245,1641],[1631,1641],[1631,1691],[245,1691]],"region":{"top_left_x":244,"top_left_y":1641,"width":1387,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"738a434192984ab9a1464bdcc3e2591f","type":"text","conversion_output":true,"text":"Adverse Event Safety Report Form (Clinical Trial) as described in Section 7.4.1.4.","text_display":" Adverse Event Safety Report Form (Clinical Trial) as described in Section 7.4.1.4.","confidence":1,"confidence_rate":1},{"cnt":[[245,1732],[1880,1732],[1880,1781],[245,1781]],"region":{"top_left_x":244,"top_left_y":1731,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3eab3e8592c4eb2ab1870896330df56","type":"text","conversion_output":true,"text":"It is important that each AE report include a description of the event, its duration (onset and","text_display":"\n\nIt is important that each AE report include a description of the event, its duration (onset and","confidence":1,"confidence_rate":1},{"cnt":[[245,1779],[1880,1779],[1880,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1778,"width":1636,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c712ff8f26142d68e22202e22f90527","type":"text","conversion_output":true,"text":"resolution dates (and times, if relevant)), its severity, its relationship with the trial treatment, any","text_display":" resolution dates (and times, if relevant)), its severity, its relationship with the trial treatment, any","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[1880,1826],[1880,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1826,"width":1636,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efbce8ce15484cca95c8b9a26e6e235f","type":"text","conversion_output":true,"text":"other potential causal factors, any treatment given or other action taken (including dose","text_display":" other potential causal factors, any treatment given or other action taken (including dose","confidence":1,"confidence_rate":1},{"cnt":[[245,1873],[1880,1873],[1880,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1873,"width":1636,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf70d98cbc6d4000b096f62eb8ba0f5b","type":"text","conversion_output":true,"text":"modification or discontinuation of the IMP), and its outcome. In addition, serious cases should","text_display":" modification or discontinuation of the IMP), and its outcome. In addition, serious cases should","confidence":0.9794921875,"confidence_rate":0.9997928112901707},{"cnt":[[245,1921],[1347,1921],[1347,1972],[245,1972]],"region":{"top_left_x":244,"top_left_y":1920,"width":1104,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c8b36fc54d44200be61a62aa10c56f8","type":"text","conversion_output":true,"text":"be identified and the appropriate seriousness criteria documented.","text_display":" be identified and the appropriate seriousness criteria documented.","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1880,2011],[1880,2062],[245,2062]],"region":{"top_left_x":244,"top_left_y":2010,"width":1636,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3528d97e78fd457ea36c5b0761869024","type":"text","conversion_output":true,"text":"Because of the i.a. route of administration used and the expectation that the great majority of the","text_display":"\n\nBecause of the i.a. route of administration used and the expectation that the great majority of the","confidence":0.9609375,"confidence_rate":0.9996169396503265},{"cnt":[[245,2058],[1880,2058],[1880,2110],[245,2110]],"region":{"top_left_x":244,"top_left_y":2058,"width":1636,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"811ede5b65134c4ab403dcc39501a88a","type":"text","conversion_output":true,"text":"injected drug will remain within the knee joint, Investigators must classify each reported AE as","text_display":" injected drug will remain within the knee joint, Investigators must classify each reported AE as","confidence":0.9970703125,"confidence_rate":0.9999709510413867},{"cnt":[[245,2108],[1880,2108],[1880,2159],[245,2159]],"region":{"top_left_x":244,"top_left_y":2107,"width":1636,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa9be953369b4c47aed718bbd38e561a","type":"text","conversion_output":true,"text":"\"local (i.e., concerning only the knee that is treated)\" or \"systemic\" in the subject's CRF to","text_display":" \"local (i.e., concerning only the knee that is treated)\" or \"systemic\" in the subject's CRF to","confidence":0.9946370096877217,"confidence_rate":0.9999456840734593},{"cnt":[[245,2157],[1656,2157],[1656,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2157,"width":1413,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"421283d35f614c1b8ec62446374cd89d","type":"text","conversion_output":true,"text":"permit separate evaluation of AEs classified as local and AEs classified as systemic.","text_display":" permit separate evaluation of AEs classified as local and AEs classified as systemic.","confidence":0.9990234375,"confidence_rate":0.9999891440628391},{"cnt":[[245,2243],[1880,2243],[1880,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2242,"width":1636,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26f143ef92e340f793b82ff6bfeb5b6e","type":"text","conversion_output":true,"text":"Specific guidance can be found in the CRF Completion and Monitoring Conventions provided","text_display":"\n\nSpecific guidance can be found in the CRF Completion and Monitoring Conventions provided","confidence":1,"confidence_rate":1},{"cnt":[[245,2295],[511,2295],[511,2344],[245,2344]],"region":{"top_left_x":244,"top_left_y":2294,"width":268,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"525fbb07bd05464da769d0793808c230","type":"text","conversion_output":true,"text":"by the Sponsor.","text_display":" by the Sponsor.","confidence":0.99951171875,"confidence_rate":0.9999755802732609},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e4076f628d8947579a274b21ee7852bd","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2548],[389,2546],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2545,"width":146,"height":42},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"972dc81acdc445cbb603e5cea844b2a8","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9e528ab4f094f27afb3845f0561d333","type":"page_info","conversion_output":false,"text":"74/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-075","page":75,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cf4da1d32c54d6799a4473340b5b588","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66848a4254524363a5ad0f0eefcaaafc","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ddcc4cf04f24adfa36ce4ec53775f56","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[1639,275],[1639,346],[241,346]],"region":{"top_left_x":240,"top_left_y":275,"width":1400,"height":71},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dede5bf2dc734eff9d604203c7a2e73e","type":"section_header","conversion_output":false,"children_ids":["53e13ee43d9245af8dcc6bdaee4a04ca"],"text":"","text_display":""},{"cnt":[[245,279],[1631,279],[1631,342],[245,342]],"region":{"top_left_x":244,"top_left_y":279,"width":1387,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53e13ee43d9245af8dcc6bdaee4a04ca","type":"text","conversion_output":true,"parent_id":"dede5bf2dc734eff9d604203c7a2e73e","text":"7.4.1.3 Definition of the Adverse Event Reporting Period","text_display":"\n\n\\subsection*{7.4.1.3 Definition of the Adverse Event Reporting Period}","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1880,374],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1817703fbb2461093abe9a28a5d7c1a","type":"text","conversion_output":true,"text":"The AE reporting period for safety surveillance begins when the subject is included into the trial","text_display":"\n\nThe AE reporting period for safety surveillance begins when the subject is included into the trial","confidence":0.9956073760986328,"confidence_rate":0.9999572601384298},{"cnt":[[245,425],[1882,425],[1882,477],[245,477]],"region":{"top_left_x":244,"top_left_y":425,"width":1639,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57a1e0ccd81b4a70bdc9ed7b65c319f6","type":"text","conversion_output":true,"text":"(date of first signature of informed consent) and continues until the end of the trial's post-","text_display":" (date of first signature of informed consent) and continues until the end of the trial's post","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[245,473],[1882,473],[1882,526],[245,526]],"region":{"top_left_x":244,"top_left_y":472,"width":1639,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68f45a49b9a5469e95dbf0d48b1a6670","type":"text","conversion_output":true,"text":"treatment extended follow-up phase, or until the subject's final trial visit in case of early","text_display":"treatment extended follow-up phase, or until the subject's final trial visit in case of early","confidence":1,"confidence_rate":1},{"cnt":[[245,524],[453,524],[453,569],[245,569]],"region":{"top_left_x":244,"top_left_y":524,"width":210,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bcd2004848342a683c8983890d0a7b7","type":"text","conversion_output":true,"text":"withdrawal.","text_display":" withdrawal.","confidence":1,"confidence_rate":1},{"cnt":[[236,606],[1626,606],[1626,681],[236,681]],"region":{"top_left_x":236,"top_left_y":605,"width":1391,"height":77},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbd17bbad23b421ea8de112cea252104","type":"section_header","conversion_output":false,"children_ids":["38b413284fd84bd989c587b1022e0264"],"text":"","text_display":""},{"cnt":[[243,610],[1620,610],[1620,672],[243,672]],"region":{"top_left_x":242,"top_left_y":610,"width":1378,"height":63},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38b413284fd84bd989c587b1022e0264","type":"text","conversion_output":true,"parent_id":"bbd17bbad23b421ea8de112cea252104","text":"7.4.1.4 Procedure for Reporting Serious Adverse Events","text_display":"\n\n\\subsection*{7.4.1.4 Procedure for Reporting Serious Adverse Events}","confidence":1,"confidence_rate":1},{"cnt":[[243,709],[1882,709],[1882,758],[243,758]],"region":{"top_left_x":242,"top_left_y":708,"width":1641,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed020709538a4dd4b140d152fdd33289","type":"text","conversion_output":true,"text":"In the event of any new SAE occurring during the reporting period, the Investigator must","text_display":"\n\nIn the event of any new SAE occurring during the reporting period, the Investigator must","confidence":0.9990234375,"confidence_rate":0.9999894942525209},{"cnt":[[245,756],[1882,756],[1882,810],[245,810]],"region":{"top_left_x":244,"top_left_y":756,"width":1639,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"994b706536d44ca298a6fa6fee978321","type":"text","conversion_output":true,"text":"immediately (i.e., within a maximum 24 HOURS after becoming aware of the event) inform the","text_display":" immediately (i.e., within a maximum 24 HOURS after becoming aware of the event) inform the","confidence":0.99853515625,"confidence_rate":0.9999850417681765},{"cnt":[[245,804],[1053,804],[1053,857],[245,857]],"region":{"top_left_x":244,"top_left_y":803,"width":809,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"075f185b0ba248dd880740785017175c","type":"text","conversion_output":true,"text":"Sponsor's GDS department by fax or by e-mail.","text_display":" Sponsor's GDS department by fax or by e-mail.","confidence":0.9985356330871582,"confidence_rate":0.99997069162658},{"cnt":[[243,894],[1880,894],[1880,947],[243,947]],"region":{"top_left_x":242,"top_left_y":893,"width":1638,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"813cefb7e2da40fb85d8b84bdcba4a7e","type":"text","conversion_output":true,"text":"Reporting procedures and timelines are the same for any new information on a previously","text_display":"\n\nReporting procedures and timelines are the same for any new information on a previously","confidence":1,"confidence_rate":1},{"cnt":[[245,941],[767,941],[767,995],[245,995]],"region":{"top_left_x":244,"top_left_y":941,"width":523,"height":54},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65ab163089464ba39eff6d322426f099","type":"text","conversion_output":true,"text":"reported SAE (i.e., follow-up).","text_display":" reported SAE (i.e., follow-up).","confidence":0.99365234375,"confidence_rate":0.9998231298577376},{"cnt":[[245,1031],[1882,1031],[1882,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1031,"width":1639,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f451ead6802400d874257d819d68bad","type":"text","conversion_output":true,"text":"For names, addresses, telephone and fax numbers for SAE reporting, see information included in","text_display":"\n\nFor names, addresses, telephone and fax numbers for SAE reporting, see information included in","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1190,1079],[1190,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1078,"width":947,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcf231329c654121a5fc31021b3b6fbb","type":"text","conversion_output":true,"text":"the Adverse Event Safety Report Form (Clinical Trials).","text_display":" the Adverse Event Safety Report Form (Clinical Trials).","confidence":1,"confidence_rate":1},{"cnt":[[245,1169],[1882,1169],[1882,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1168,"width":1639,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82ed4146b6d44a8f9bc661bc418a9af2","type":"text","conversion_output":true,"text":"All written reports should be transmitted using the Adverse Event Safety Report Form (Clinical","text_display":"\n\nAll written reports should be transmitted using the Adverse Event Safety Report Form (Clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1863,1216],[1863,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1216,"width":1619,"height":54},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f5d03e7f20c43f08db7f4849f007577","type":"text","conversion_output":true,"text":"Trials), which must be completed by the Investigator following specific completion instructions.","text_display":" Trials), which must be completed by the Investigator following specific completion instructions.","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1882,1306],[1882,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1306,"width":1639,"height":54},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad72634ac0c34bc3b0a24a54603ed2ab","type":"text","conversion_output":true,"text":"Relevant pages from the CRF may be provided in parallel (e.g., medical history, concomitant","text_display":"\n\nRelevant pages from the CRF may be provided in parallel (e.g., medical history, concomitant","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1882,1354],[1882,1405],[245,1405]],"region":{"top_left_x":244,"top_left_y":1353,"width":1639,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1334a65185fd4ebe85b6c338265ddfdf","type":"text","conversion_output":true,"text":"medications). In all cases, the information provided in the Adverse Event Safety Report Form","text_display":" medications). In all cases, the information provided in the Adverse Event Safety Report Form","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1880,1401],[1880,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94d2d1d0138149f8925c27627a039689","type":"text","conversion_output":true,"text":"(Clinical Trials) must be consistent with the data on the event that are recorded in the","text_display":" (Clinical Trials) must be consistent with the data on the event that are recorded in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1452],[844,1452],[844,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1452,"width":601,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63ddc126b542461590e76a6be950f3dd","type":"text","conversion_output":true,"text":"corresponding sections of the CRF.","text_display":" corresponding sections of the CRF.","confidence":1,"confidence_rate":1},{"cnt":[[245,1538],[1880,1538],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1538,"width":1636,"height":54},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"148192b3a619422cba97aacecc8f37c4","type":"text","conversion_output":true,"text":"The Investigator/Reporter must respond to any request for follow-up information (e.g., additional","text_display":"\n\nThe Investigator/Reporter must respond to any request for follow-up information (e.g., additional","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[1880,1590],[1880,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1589,"width":1636,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e92a22e0cfa45389b12bd3e3f040503","type":"text","conversion_output":true,"text":"information, outcome and final evaluation, specific records where needed) or to any question the","text_display":" information, outcome and final evaluation, specific records where needed) or to any question the","confidence":1,"confidence_rate":1},{"cnt":[[245,1637],[1880,1637],[1880,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1637,"width":1636,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad53dcf0731d4d999fc1f01ec1452246","type":"text","conversion_output":true,"text":"Sponsor may have on the AE within the same timelines as described for initial reports. This is","text_display":" Sponsor may have on the AE within the same timelines as described for initial reports. This is","confidence":1,"confidence_rate":1},{"cnt":[[245,1684],[1880,1684],[1880,1734],[245,1734]],"region":{"top_left_x":244,"top_left_y":1684,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b7a70e37c9f4b6eab846df10e9fd6a4","type":"text","conversion_output":true,"text":"necessary to permit a prompt assessment of the event by the Sponsor and (as applicable) to allow","text_display":" necessary to permit a prompt assessment of the event by the Sponsor and (as applicable) to allow","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1732],[1880,1732],[1880,1781],[245,1781]],"region":{"top_left_x":244,"top_left_y":1731,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8c6b11d3ff84d348ea3acef21f0f899","type":"text","conversion_output":true,"text":"the Company to meet strict regulatory timelines associated with expedited safety reporting","text_display":" the Company to meet strict regulatory timelines associated with expedited safety reporting","confidence":1,"confidence_rate":1},{"cnt":[[245,1779],[449,1779],[449,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1778,"width":206,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90dd10ab71934e1e9525b966f06bf623","type":"text","conversion_output":true,"text":"obligations.","text_display":" obligations.","confidence":1,"confidence_rate":1},{"cnt":[[245,1869],[1880,1869],[1880,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1869,"width":1636,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bebe1729806f4cd7931ab0524b3e0106","type":"text","conversion_output":true,"text":"Requests for follow-up will usually be made by the responsible Monitor, although in exceptional","text_display":"\n\nRequests for follow-up will usually be made by the responsible Monitor, although in exceptional","confidence":1,"confidence_rate":1},{"cnt":[[245,1916],[1882,1916],[1882,1968],[245,1968]],"region":{"top_left_x":244,"top_left_y":1916,"width":1639,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61088584297648ff91e543d7c7fd2722","type":"text","conversion_output":true,"text":"circumstances the GDS department may contact the Investigator directly to obtain clarification or","text_display":" circumstances the GDS department may contact the Investigator directly to obtain clarification or","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[883,1964],[883,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1963,"width":640,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a74c80ffe16246ae8a7753f53a1944c0","type":"text","conversion_output":true,"text":"to discuss a particularly critical event.","text_display":" to discuss a particularly critical event.","confidence":1,"confidence_rate":1},{"cnt":[[241,2050],[1886,2050],[1886,2176],[241,2176]],"region":{"top_left_x":240,"top_left_y":2049,"width":1647,"height":128},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4dce60c0d954640b48b17092fbcffad","type":"section_header","conversion_output":false,"children_ids":["22d42d86f2b0479d9ec9dac2a389d77d","ade649d4e8cc43b3b389a2afe218ec7c"],"text":"","text_display":""},{"cnt":[[245,2056],[1880,2056],[1880,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2056,"width":1636,"height":61},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22d42d86f2b0479d9ec9dac2a389d77d","type":"text","conversion_output":true,"parent_id":"f4dce60c0d954640b48b17092fbcffad","text":"7.4.1.5 Safety Reporting to Health Authorities, Independent Ethics","text_display":"\n\n\\subsection*{7.4.1.5 Safety Reporting to Health Authorities, Independent Ethics","confidence":0.99853515625,"confidence_rate":0.9999793534852197},{"cnt":[[595,2114],[1833,2114],[1833,2172],[595,2172]],"region":{"top_left_x":595,"top_left_y":2114,"width":1238,"height":59},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ade649d4e8cc43b3b389a2afe218ec7c","type":"text","conversion_output":true,"parent_id":"f4dce60c0d954640b48b17092fbcffad","text":"Committees/ Institutional Review Boards and Investigators","text_display":" Committees/ Institutional Review Boards and Investigators}","confidence":0.99951171875,"confidence_rate":0.999992122603638},{"cnt":[[245,2209],[1880,2209],[1880,2258],[245,2258]],"region":{"top_left_x":244,"top_left_y":2208,"width":1636,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fb0cd5e3ed744228a1253c7f42d93c8","type":"text","conversion_output":true,"text":"The Sponsor will send appropriate safety notifications to Health Authorities in accordance with","text_display":"\n\nThe Sponsor will send appropriate safety notifications to Health Authorities in accordance with","confidence":1,"confidence_rate":1},{"cnt":[[245,2256],[788,2256],[788,2307],[245,2307]],"region":{"top_left_x":244,"top_left_y":2255,"width":545,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f64f33d4d91a4e58b4301563c8716c85","type":"text","conversion_output":true,"text":"applicable laws and regulations.","text_display":" applicable laws and regulations.","confidence":1,"confidence_rate":1},{"cnt":[[245,2346],[1880,2346],[1880,2396],[245,2396]],"region":{"top_left_x":244,"top_left_y":2346,"width":1636,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68df6de1258645739c8eee6e894f3535","type":"text","conversion_output":true,"text":"The Investigator must comply with any applicable site-specific requirements related to the","text_display":"\n\nThe Investigator must comply with any applicable site-specific requirements related to the","confidence":1,"confidence_rate":1},{"cnt":[[245,2393],[1882,2393],[1882,2443],[245,2443]],"region":{"top_left_x":244,"top_left_y":2393,"width":1639,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de806b468bc24a709dd84d1876c6f8d6","type":"text","conversion_output":true,"text":"reporting of SAEs (and in particular deaths) involving his/her subjects to the IEC/IRB that","text_display":" reporting of SAEs (and in particular deaths) involving his/her subjects to the IEC/IRB that","confidence":1,"confidence_rate":1},{"cnt":[[245,2441],[556,2441],[556,2490],[245,2490]],"region":{"top_left_x":244,"top_left_y":2440,"width":313,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"400de523d9dd4611b60bc09f38084f9c","type":"text","conversion_output":true,"text":"approved the trial.","text_display":" approved the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9872603086174957b4630befcbb0f9eb","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2546],[389,2544],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":43},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"62340a1d0bfc43e196bdb761c5b92a0f","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92d180a5d4d94f5887e34ae67da86ad9","type":"page_info","conversion_output":false,"text":"75/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-076","page":76,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52935bcc1949493fb457bae185ef1340","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d5e14f32fb44ee8b142f78cc7b020ce","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b19b1b4a56d04f209006d5621f41a514","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea7bf31aa0c94fe48fb4cdde3eef1a63","type":"text","conversion_output":true,"text":"In accordance with ICH GCP guidelines, the Sponsor will inform the Investigator of \"findings","text_display":"\n\nIn accordance with ICH GCP guidelines, the Sponsor will inform the Investigator of \"findings","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1882,329],[1882,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1639,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5a09c46b1da4d1cbeb6a377e9a73731","type":"text","conversion_output":true,"text":"that could adversely affect the safety of subjects, impact the conduct of the trial or alter the","text_display":" that could adversely affect the safety of subjects, impact the conduct of the trial or alter the","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1880,374],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9506e314438c48a194b08c19c37dfc0a","type":"text","conversion_output":true,"text":"IEC's/IRB's approval/favorable opinion to continue the trial.\" In particular and in line with","text_display":" IEC's/IRB's approval/favorable opinion to continue the trial.\" In particular and in line with","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[245,423],[1880,423],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":423,"width":1636,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cee76f4bbf794a3c979be20528b4a1f6","type":"text","conversion_output":true,"text":"respective regulations, the Sponsor will inform the Investigator of AEs that are both serious and","text_display":" respective regulations, the Sponsor will inform the Investigator of AEs that are both serious and","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1880,473],[1880,522],[245,522]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b26df10210f04436bd37c1f0b3b2fc5a","type":"text","conversion_output":true,"text":"unexpected and are considered to be related to the administered product (\"suspected unexpected","text_display":" unexpected and are considered to be related to the administered product (\"suspected unexpected","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1880,520],[1880,571],[245,571]],"region":{"top_left_x":244,"top_left_y":519,"width":1636,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4ed259933ab444c9ccd352b836a508b","type":"text","conversion_output":true,"text":"serious adverse reactions\" or SUSARs). The Investigator should place copies of Safety reports in","text_display":" serious adverse reactions\" or SUSARs). The Investigator should place copies of Safety reports in","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[245,567],[1880,567],[1880,621],[245,621]],"region":{"top_left_x":244,"top_left_y":567,"width":1636,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a55bc37bb49471fae313b094e838df9","type":"text","conversion_output":true,"text":"the Investigator Site File. National regulations with regard to Safety report notifications to","text_display":" the Investigator Site File. National regulations with regard to Safety report notifications to","confidence":0.9941482543945312,"confidence_rate":0.9999407195939513},{"cnt":[[245,614],[922,614],[922,666],[245,666]],"region":{"top_left_x":244,"top_left_y":614,"width":678,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a94f89e65774b36b23b60c12e049c1e","type":"text","conversion_output":true,"text":"Investigators will be taken into account.","text_display":" Investigators will be taken into account.","confidence":1,"confidence_rate":1},{"cnt":[[245,705],[1880,705],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":704,"width":1636,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"043a826d3db74eddab8b551503b9896a","type":"text","conversion_output":true,"text":"When specifically required by regulations and guidelines, the Sponsor will provide appropriate","text_display":"\n\nWhen specifically required by regulations and guidelines, the Sponsor will provide appropriate","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1880,752],[1880,804],[245,804]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8145ce9e2c184cd9b355b1657bd92390","type":"text","conversion_output":true,"text":"Safety reports directly to the concerned lead IEC/IRB and will maintain records of these","text_display":" Safety reports directly to the concerned lead IEC/IRB and will maintain records of these","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[1880,799],[1880,853],[245,853]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c91e3ff4bfe450f8173198907d361b6","type":"text","conversion_output":true,"text":"notifications. When direct reporting by the Sponsor is not clearly defined by national or site-","text_display":" notifications. When direct reporting by the Sponsor is not clearly defined by national or site","confidence":0.9990234375,"confidence_rate":0.999990229651252},{"cnt":[[245,846],[1880,846],[1880,900],[245,900]],"region":{"top_left_x":244,"top_left_y":846,"width":1636,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1534460d80024d4ba99dba73dce843e2","type":"text","conversion_output":true,"text":"specific regulations, the Investigator will be responsible for promptly notifying the concerned","text_display":"specific regulations, the Investigator will be responsible for promptly notifying the concerned","confidence":1,"confidence_rate":1},{"cnt":[[245,898],[1880,898],[1880,947],[245,947]],"region":{"top_left_x":244,"top_left_y":898,"width":1636,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe27b725283944199be1d59c257f935e","type":"text","conversion_output":true,"text":"IEC/IRB of any Safety reports provided by the Sponsor and of filing copies of all related","text_display":" IEC/IRB of any Safety reports provided by the Sponsor and of filing copies of all related","confidence":0.990234375,"confidence_rate":0.9998956052213405},{"cnt":[[245,945],[990,945],[990,999],[245,999]],"region":{"top_left_x":244,"top_left_y":945,"width":747,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"021c1693a9b84972a4595b7ac64182e5","type":"text","conversion_output":true,"text":"correspondence in the Investigator Site File.","text_display":" correspondence in the Investigator Site File.","confidence":0.99951171875,"confidence_rate":0.9999902320377446},{"cnt":[[245,1033],[1880,1033],[1880,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1033,"width":1636,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80245c8a0cfc4c359398c2081f2f83b0","type":"text","conversion_output":true,"text":"For trials covered by the European Directive 2001/20/EC, the Sponsor's responsibilities","text_display":"\n\nFor trials covered by the European Directive 2001/20/EC, the Sponsor's responsibilities","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,1083],[1880,1083],[1880,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1082,"width":1636,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79eea35e1a3a4613a83baa893b3457f1","type":"text","conversion_output":true,"text":"regarding the reporting of SAEs/SUSARs/Safety Issues will be carried out in accordance with","text_display":" regarding the reporting of SAEs/SUSARs/Safety Issues will be carried out in accordance with","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1171,1130],[1171,1177],[245,1177]],"region":{"top_left_x":244,"top_left_y":1130,"width":927,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"046f5a700f9f4344a193f42378268fa9","type":"text","conversion_output":true,"text":"that Directive and with the related Detailed Guidances.","text_display":" that Directive and with the related Detailed Guidances.","confidence":1,"confidence_rate":1},{"cnt":[[236,1216],[1528,1216],[1528,1287],[236,1287]],"region":{"top_left_x":236,"top_left_y":1216,"width":1292,"height":71},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bfe47a88341475bbdfcaa233b01d019","type":"section_header","conversion_output":false,"children_ids":["262a0e5aaac34c2fa66ab9c545fedec9"],"text":"","text_display":""},{"cnt":[[245,1222],[1521,1222],[1521,1278],[245,1278]],"region":{"top_left_x":244,"top_left_y":1222,"width":1278,"height":57},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"262a0e5aaac34c2fa66ab9c545fedec9","type":"text","conversion_output":true,"parent_id":"0bfe47a88341475bbdfcaa233b01d019","text":"7.4.1.6 Monitoring of Subjects with Adverse Events","text_display":"\n\n\\subsection*{7.4.1.6 Monitoring of Subjects with Adverse Events}","confidence":1,"confidence_rate":1},{"cnt":[[243,1317],[1880,1317],[1880,1369],[243,1369]],"region":{"top_left_x":242,"top_left_y":1316,"width":1638,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2fd736cb5d44f02b75de96801f7b901","type":"text","conversion_output":true,"text":"Any AE that occurs during the course of a clinical trial and is considered to be possibly related to","text_display":"\n\nAny AE that occurs during the course of a clinical trial and is considered to be possibly related to","confidence":1,"confidence_rate":1},{"cnt":[[245,1366],[1880,1366],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1366,"width":1636,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e5473b12e534b7c8bb62120c064c0ed","type":"text","conversion_output":true,"text":"the IMP must be monitored and followed up by the Investigator until stabilization or until the","text_display":" the IMP must be monitored and followed up by the Investigator until stabilization or until the","confidence":1,"confidence_rate":1},{"cnt":[[245,1414],[1880,1414],[1880,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"704e7013fe68456aa097946d2b3069e2","type":"text","conversion_output":true,"text":"outcome is known, unless the subject is documented as \"lost to follow-up\". Reasonable attempts","text_display":" outcome is known, unless the subject is documented as \"lost to follow-up\". Reasonable attempts","confidence":0.99853515625,"confidence_rate":0.9999851928603086},{"cnt":[[245,1461],[1880,1461],[1880,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1460,"width":1636,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b165f3e91b1049c19ec0d2a93012d9ec","type":"text","conversion_output":true,"text":"to obtain this information must be made and documented. It is also the responsibility of the","text_display":" to obtain this information must be made and documented. It is also the responsibility of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1508],[1880,1508],[1880,1560],[245,1560]],"region":{"top_left_x":244,"top_left_y":1508,"width":1636,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74d18e6441f84552b873d9adccec482b","type":"text","conversion_output":true,"text":"Investigator to ensure that any necessary additional therapeutic measures and follow-up","text_display":" Investigator to ensure that any necessary additional therapeutic measures and follow-up","confidence":1,"confidence_rate":1},{"cnt":[[245,1558],[1880,1558],[1880,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1557,"width":1636,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fa6f1c7a6254d848432618d2a9e0f56","type":"text","conversion_output":true,"text":"procedures are performed. The Sponsor will actively follow up and collect information on any","text_display":" procedures are performed. The Sponsor will actively follow up and collect information on any","confidence":1,"confidence_rate":1},{"cnt":[[245,1607],[1880,1607],[1880,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1607,"width":1636,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d541ac6eee4141c4a5fbbc1183a47364","type":"text","conversion_output":true,"text":"AE that occurs during the course of a clinical trial; however, while this activity will continue for","text_display":" AE that occurs during the course of a clinical trial; however, while this activity will continue for","confidence":0.9985356330871582,"confidence_rate":0.9999860435245741},{"cnt":[[245,1654],[1880,1654],[1880,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1654,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07a1ced9ad8c48b3a5c115320ec109b9","type":"text","conversion_output":true,"text":"any serious AEs until stabilization or until the outcome is known, it will be discontinued at the","text_display":" any serious AEs until stabilization or until the outcome is known, it will be discontinued at the","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[965,1702],[965,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":721,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84983aaac3aa419489e3cf58ac520175","type":"text","conversion_output":true,"text":"time of database lock for non-serious AEs.","text_display":" time of database lock for non-serious AEs.","confidence":1,"confidence_rate":1},{"cnt":[[241,1788],[1442,1788],[1442,1858],[241,1858]],"region":{"top_left_x":240,"top_left_y":1787,"width":1202,"height":72},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2cfa0bd582584fc788ae8019888dd60b","type":"section_header","conversion_output":false,"children_ids":["b3c01cf339ca480289d66d2485c3456e"],"text":"","text_display":""},{"cnt":[[245,1792],[1437,1792],[1437,1852],[245,1852]],"region":{"top_left_x":244,"top_left_y":1791,"width":1194,"height":61},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3c01cf339ca480289d66d2485c3456e","type":"text","conversion_output":true,"parent_id":"2cfa0bd582584fc788ae8019888dd60b","text":"7.4.2 Pregnancy and In Utero Drug Exposure","text_display":"\n\n\\subsection*{7.4.2 Pregnancy and In Utero Drug Exposure}","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1880,1886],[1880,1940],[245,1940]],"region":{"top_left_x":244,"top_left_y":1886,"width":1636,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8b78b1dcc7945329f6c3ebc53a7b97c","type":"text","conversion_output":true,"text":"Only pregnancies considered by the Investigator as related to trial treatment (e.g., resulting from","text_display":"\n\nOnly pregnancies considered by the Investigator as related to trial treatment (e.g., resulting from","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1880,1938],[1880,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1937,"width":1636,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"970bbc670a3e4d6aa0f4b7c805909a6e","type":"text","conversion_output":true,"text":"a drug interaction with a contraceptive medication) are considered as AEs. However, all","text_display":" a drug interaction with a contraceptive medication) are considered as AEs. However, all","confidence":1,"confidence_rate":1},{"cnt":[[245,1985],[1880,1985],[1880,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1985,"width":1636,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d45bb5e0c33c40f186b26d6285793cfe","type":"text","conversion_output":true,"text":"pregnancies with an estimated conception date during the period defined in Section 7.4.1.3 must","text_display":" pregnancies with an estimated conception date during the period defined in Section 7.4.1.3 must","confidence":1,"confidence_rate":1},{"cnt":[[245,2032],[1880,2032],[1880,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2032,"width":1636,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fe15511d77c4850a95dadbbbc64b245","type":"text","conversion_output":true,"text":"be recorded by convention in the AE page/section of the CRF. The Investigator must notify the","text_display":" be recorded by convention in the AE page/section of the CRF. The Investigator must notify the","confidence":1,"confidence_rate":1},{"cnt":[[245,2080],[1882,2080],[1882,2129],[245,2129]],"region":{"top_left_x":244,"top_left_y":2079,"width":1639,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8be71e7c2c4547ea87254956d3649537","type":"text","conversion_output":true,"text":"Sponsor in an expedited manner of any pregnancy using the Pregnancy Report Form, which must","text_display":" Sponsor in an expedited manner of any pregnancy using the Pregnancy Report Form, which must","confidence":1,"confidence_rate":1},{"cnt":[[245,2127],[1841,2127],[1841,2179],[245,2179]],"region":{"top_left_x":244,"top_left_y":2126,"width":1598,"height":53},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcde7af8cc724999a784d74d8424cc4d","type":"text","conversion_output":true,"text":"be transmitted according to the same process as described for SAE reporting in Section 7.4.1.4.","text_display":" be transmitted according to the same process as described for SAE reporting in Section 7.4.1.4.","confidence":1,"confidence_rate":1},{"cnt":[[245,2217],[1880,2217],[1880,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2217,"width":1636,"height":54},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46a6c13fa8b14598abc2122b933cecaf","type":"text","conversion_output":true,"text":"Investigators must actively follow up, document and report on the outcome of all these","text_display":"\n\nInvestigators must actively follow up, document and report on the outcome of all these","confidence":1,"confidence_rate":1},{"cnt":[[245,2264],[1283,2264],[1283,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2264,"width":1039,"height":55},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7714fe09dc39480eb0e2c70a30473a8d","type":"text","conversion_output":true,"text":"pregnancies, even if the subjects are withdrawn from the trial.","text_display":" pregnancies, even if the subjects are withdrawn from the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,2355],[1880,2355],[1880,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2354,"width":1636,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbbd9f6e8c7b45679a1d3d94dd60c5d5","type":"text","conversion_output":true,"text":"The Investigator must notify the Sponsor of these outcomes using the Pregnancy Report Form,","text_display":"\n\nThe Investigator must notify the Sponsor of these outcomes using the Pregnancy Report Form,","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1880,2402],[1880,2454],[245,2454]],"region":{"top_left_x":244,"top_left_y":2401,"width":1636,"height":53},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7270536608504767af8cf0472dc8169f","type":"text","conversion_output":true,"text":"and in case of abnormal outcome, the Adverse Event Safety Report Form (Clinical Trials) when","text_display":" and in case of abnormal outcome, the Adverse Event Safety Report Form (Clinical Trials) when","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e444701358c94d15b6118d0edc86a10f","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2545],[390,2587],[245,2589]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":46},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4b7e6b9487e2486289fa39ef030a1dd9","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.9990234375,"confidence_rate":0.9999348661447799},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"393a76da2bd0465ea211b5d5c3aa3ade","type":"page_info","conversion_output":false,"text":"76/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-077","page":77,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27db48cffdcd47d3badaa3703db30d3f","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2abf464feba498391429d6feea39ae5","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4424d584d8b4d05a9324653ecf85262","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02d27fca612b4b749c1f5a44758369a7","type":"text","conversion_output":true,"text":"the subject sustains an event, and the Parent-Child/Fetus Adverse Event Report Form when the","text_display":"\nthe subject sustains an event, and the Parent-Child/Fetus Adverse Event Report Form when the","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[733,329],[733,376],[245,376]],"region":{"top_left_x":244,"top_left_y":328,"width":489,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f00a2ca441cb400aa2c92b51ffd2702c","type":"text","conversion_output":true,"text":"child/fetus sustains an event.","text_display":" child/fetus sustains an event.","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1880,417],[1880,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec42c74b6b214e0f8dac076af38995b0","type":"text","conversion_output":true,"text":"Any abnormal outcome must be reported in an expedited manner as described in Section 7.4.1.4,","text_display":"\n\nAny abnormal outcome must be reported in an expedited manner as described in Section 7.4.1.4,","confidence":1,"confidence_rate":1},{"cnt":[[245,466],[1439,466],[1439,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1196,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27e1fdce09874f3f957327a26853a807","type":"text","conversion_output":true,"text":"while normal outcomes must be reported within 45 days from delivery.","text_display":" while normal outcomes must be reported within 45 days from delivery.","confidence":0.99951171875,"confidence_rate":0.9999935736983052},{"cnt":[[245,554],[1880,554],[1880,606],[245,606]],"region":{"top_left_x":244,"top_left_y":554,"width":1636,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ed417d2f2194b5088f0e4dad13dea14","type":"text","conversion_output":true,"text":"In the event of a pregnancy in a subject occurring during the course of the trial, the subject must","text_display":"\n\nIn the event of a pregnancy in a subject occurring during the course of the trial, the subject must","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1882,602],[1882,655],[245,655]],"region":{"top_left_x":244,"top_left_y":601,"width":1639,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bf48c8a99a64b378fba52aa0efd655e","type":"text","conversion_output":true,"text":"be discontinued from trial medication immediately. The Sponsor must be notified without delay","text_display":" be discontinued from trial medication immediately. The Sponsor must be notified without delay","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1154,649],[1154,703],[245,703]],"region":{"top_left_x":244,"top_left_y":648,"width":910,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbae0b33d40740d3b07e1b11aab6acc0","type":"text","conversion_output":true,"text":"and the subject must be followed as mentioned above.","text_display":" and the subject must be followed as mentioned above.","confidence":1,"confidence_rate":1},{"cnt":[[241,739],[1119,739],[1119,806],[241,806]],"region":{"top_left_x":240,"top_left_y":739,"width":880,"height":67},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29d18a46251b4f449b18b060ffc21f13","type":"section_header","conversion_output":false,"children_ids":["2e4b834cd6fb491eb3917e91a3c9335e","99e9c32e193e411a81e7417e21dfde90"],"text":"","text_display":""},{"cnt":[[245,743],[350,743],[350,793],[245,793]],"region":{"top_left_x":244,"top_left_y":743,"width":107,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e4b834cd6fb491eb3917e91a3c9335e","type":"text","conversion_output":true,"parent_id":"29d18a46251b4f449b18b060ffc21f13","text":"7.4.3","text_display":"\n\n\\subsection*{7.4.3","confidence":1,"confidence_rate":1},{"cnt":[[593,743],[1113,743],[1113,799],[593,799]],"region":{"top_left_x":592,"top_left_y":743,"width":521,"height":57},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99e9c32e193e411a81e7417e21dfde90","type":"text","conversion_output":true,"parent_id":"29d18a46251b4f449b18b060ffc21f13","text":"Laboratory Assessments","text_display":" Laboratory Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[245,838],[1880,838],[1880,889],[245,889]],"region":{"top_left_x":244,"top_left_y":837,"width":1636,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f5d3e16e06b41168c6fd7f250eb11a6","type":"text","conversion_output":true,"text":"Standard laboratory assessments in this trial will consist of hematology, clinical biochemistry,","text_display":"\n\nStandard laboratory assessments in this trial will consist of hematology, clinical biochemistry,","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1592,885],[1592,939],[245,939]],"region":{"top_left_x":244,"top_left_y":885,"width":1348,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4be197a61fba4281b634102f1a933b6d","type":"text","conversion_output":true,"text":"and urinalysis panels: complete lists of parameters are presented in Appendix B.","text_display":" and urinalysis panels: complete lists of parameters are presented in Appendix B.","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[245,975],[1880,975],[1880,1027],[245,1027]],"region":{"top_left_x":244,"top_left_y":975,"width":1636,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ab5ba5ad1d04cccbb2bdd0861253e60","type":"text","conversion_output":true,"text":"As an exogenous protein, sprifermin has the potential to trigger antibody formation, which could","text_display":"\n\nAs an exogenous protein, sprifermin has the potential to trigger antibody formation, which could","confidence":1,"confidence_rate":1},{"cnt":[[245,1023],[1880,1023],[1880,1076],[245,1076]],"region":{"top_left_x":244,"top_left_y":1022,"width":1636,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0e8be23e21e4de5945dc573c277a170","type":"text","conversion_output":true,"text":"conceivably have safety, PK, or efficacy implications. Thus, subjects will be tested for binding","text_display":" conceivably have safety, PK, or efficacy implications. Thus, subjects will be tested for binding","confidence":1,"confidence_rate":1},{"cnt":[[245,1070],[1882,1070],[1882,1124],[245,1124]],"region":{"top_left_x":244,"top_left_y":1069,"width":1639,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ab82a1e886441d6ad643e0126632bb8","type":"text","conversion_output":true,"text":"and neutralizing antibodies to sprifermin/FGF-18. Only samples that are found to be positive for","text_display":" and neutralizing antibodies to sprifermin/FGF-18. Only samples that are found to be positive for","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[245,1119],[1257,1119],[1257,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1119,"width":1013,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32938144103543ccb956d321e4ec1ebf","type":"text","conversion_output":true,"text":"binding antibodies will be tested for neutralizing antibodies.","text_display":" binding antibodies will be tested for neutralizing antibodies.","confidence":1,"confidence_rate":1},{"cnt":[[245,1207],[1880,1207],[1880,1261],[245,1261]],"region":{"top_left_x":244,"top_left_y":1207,"width":1636,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3fcc5800bd9406cb8dd8a777a59c836","type":"text","conversion_output":true,"text":"Blood, urine, and synovial fluid samples for laboratory assessment will be collected at the time","text_display":"\n\nBlood, urine, and synovial fluid samples for laboratory assessment will be collected at the time","confidence":1,"confidence_rate":1},{"cnt":[[245,1257],[782,1257],[782,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1256,"width":539,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f77e3f1bb5254143b519306fba7042e3","type":"text","conversion_output":true,"text":"points indicated in Appendix E.","text_display":" points indicated in Appendix E.","confidence":0.99951171875,"confidence_rate":0.9999864334115239},{"cnt":[[245,1328],[1880,1328],[1880,1381],[245,1381]],"region":{"top_left_x":244,"top_left_y":1327,"width":1636,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b54bd0124c5d448fae44539dc31954e3","type":"text","conversion_output":true,"text":"- Subjects are not required to fast before routine laboratory sample collection in this protocol,","text_display":"\n- Subjects are not required to fast before routine laboratory sample collection in this protocol,","confidence":1,"confidence_rate":1},{"cnt":[[292,1377],[1818,1377],[1818,1429],[292,1429]],"region":{"top_left_x":292,"top_left_y":1377,"width":1526,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d962b27aaa1a40648750fea74e9364b9","type":"text","conversion_output":true,"text":"however, an 8 -hour fast is required before blood or urine sample collection for biomarkers.","text_display":" however, an 8 -hour fast is required before blood or urine sample collection for biomarkers.","confidence":0.89306640625,"confidence_rate":0.998869695897759},{"cnt":[[245,1448],[1880,1448],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1448,"width":1636,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a793baea5854d259fe6152139b283b4","type":"text","conversion_output":true,"text":"- For time points where IMP injections are administered, blood and urine samples will be","text_display":"\n- For time points where IMP injections are administered, blood and urine samples will be","confidence":1,"confidence_rate":1},{"cnt":[[294,1495],[617,1495],[617,1549],[294,1549]],"region":{"top_left_x":294,"top_left_y":1495,"width":323,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c81ef14ed034c55883e4395a3f2826b","type":"text","conversion_output":true,"text":"collected pre-dose.","text_display":" collected pre-dose.","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1828,1568],[1828,1620],[245,1620]],"region":{"top_left_x":244,"top_left_y":1568,"width":1585,"height":52},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd173310bdcf4669bb8c7a723ab42b35","type":"text","conversion_output":true,"text":"- For measurement of biomarkers in urine, second morning void samples should be obtained.","text_display":"\n- For measurement of biomarkers in urine, second morning void samples should be obtained.","confidence":1,"confidence_rate":1},{"cnt":[[245,1637],[1880,1637],[1880,1691],[245,1691]],"region":{"top_left_x":244,"top_left_y":1637,"width":1636,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8d9df5a29824daba0e23fe0fdc4d795","type":"text","conversion_output":true,"text":"- Synovial fluid samples will be collected immediately before injection of the IMP as described","text_display":"\n- Synovial fluid samples will be collected immediately before injection of the IMP as described","confidence":1,"confidence_rate":1},{"cnt":[[294,1689],[509,1689],[509,1734],[294,1734]],"region":{"top_left_x":294,"top_left_y":1688,"width":216,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4697446efa844f709abab40638388dde","type":"text","conversion_output":true,"text":"in the MOP.","text_display":" in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,1775],[1880,1775],[1880,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1774,"width":1636,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fc3aca9d1474130b7f71ec99a805d79","type":"text","conversion_output":true,"text":"PK assessments are described in Section 7.5, and biomarker and PGt assessments are described","text_display":"\n\nPK assessments are described in Section 7.5, and biomarker and PGt assessments are described","confidence":1,"confidence_rate":1},{"cnt":[[245,1824],[492,1824],[492,1871],[245,1871]],"region":{"top_left_x":244,"top_left_y":1824,"width":248,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fbf12a6bfe3425093eeb485ca35bce8","type":"text","conversion_output":true,"text":"in Section 7.6.","text_display":" in Section 7.6.","confidence":0.99169921875,"confidence_rate":0.9995833156081138},{"cnt":[[245,1914],[1880,1914],[1880,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1914,"width":1636,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04ef3894a4344c39a571ae6fadf0db57","type":"text","conversion_output":true,"text":"All laboratory assessments will be performed centrally. Instructions for sample collection,","text_display":"\n\nAll laboratory assessments will be performed centrally. Instructions for sample collection,","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1076,1964],[1076,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1963,"width":833,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"589d142b040d40cab38a523813b9db9f","type":"text","conversion_output":true,"text":"handling, and shipment are provided in the MOP.","text_display":" handling, and shipment are provided in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[243,2050],[552,2050],[552,2108],[243,2108]],"region":{"top_left_x":242,"top_left_y":2049,"width":311,"height":59},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eb724d4e5284a7ea8a08e0fec70d6b4","type":"section_header","conversion_output":false,"children_ids":["a4a576c5f45f42bd90ffded8e6cd2cb0"],"text":"","text_display":""},{"cnt":[[245,2054],[548,2054],[548,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2053,"width":304,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4a576c5f45f42bd90ffded8e6cd2cb0","type":"text","conversion_output":true,"parent_id":"5eb724d4e5284a7ea8a08e0fec70d6b4","text":"Pregnancy Tests","text_display":"\n\n\\section*{Pregnancy Tests}","confidence":1,"confidence_rate":1},{"cnt":[[245,2142],[1880,2142],[1880,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2141,"width":1636,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"101c573f3e604a53a9c89078ae722ad4","type":"text","conversion_output":true,"text":"For women of childbearing potential, pregnancy tests will be performed at the time points shown","text_display":"\n\nFor women of childbearing potential, pregnancy tests will be performed at the time points shown","confidence":0.996584415435791,"confidence_rate":0.9999657862754068},{"cnt":[[245,2191],[1880,2191],[1880,2241],[245,2241]],"region":{"top_left_x":244,"top_left_y":2191,"width":1636,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8d589c5bd7e40de8070accdf7d23530","type":"text","conversion_output":true,"text":"in Appendix E (during screening, before each injection of IMP, and at each visit involving X-ray","text_display":" in Appendix E (during screening, before each injection of IMP, and at each visit involving X-ray","confidence":1,"confidence_rate":1},{"cnt":[[245,2239],[1880,2239],[1880,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2238,"width":1636,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7d64c839c6a4b4ebf806ec2ad20470a","type":"text","conversion_output":true,"text":"and MRI). A serum test will be performed during screening, and urine tests will be performed at","text_display":" and MRI). A serum test will be performed during screening, and urine tests will be performed at","confidence":1,"confidence_rate":1},{"cnt":[[245,2286],[647,2286],[647,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2285,"width":403,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ebd79aa8b8443c9ae309e565e4c29c8","type":"text","conversion_output":true,"text":"subsequent time points.","text_display":" subsequent time points.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b8e166ec1cbe4a8b994e4f0eb7a51410","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2546],[389,2546],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2545,"width":145,"height":42},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ef136573d8f0401eb86dd9e05831b99d","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcf6eaa13ad64ba89498fb9f317a29e6","type":"page_info","conversion_output":false,"text":"77/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-078","page":78,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc8f30f400fe408ebead124a7642205b","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c6462931f054b188190d2be1126e63e","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49ba58e0d88e4f9fb3693889728b956b","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[1270,275],[1270,337],[241,337]],"region":{"top_left_x":240,"top_left_y":275,"width":1030,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2be1eda1ee5b478fbcbfed483154c862","type":"section_header","conversion_output":false,"children_ids":["659ab65783f44010a4be77927ba7337b"],"text":"","text_display":""},{"cnt":[[245,279],[1265,279],[1265,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1022,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"659ab65783f44010a4be77927ba7337b","type":"text","conversion_output":true,"parent_id":"2be1eda1ee5b478fbcbfed483154c862","text":"Management of Subjects with Laboratory Abnormalities","text_display":"\n\n\\section*{Management of Subjects with Laboratory Abnormalities}","confidence":1,"confidence_rate":1},{"cnt":[[245,370],[1882,370],[1882,419],[245,419]],"region":{"top_left_x":244,"top_left_y":369,"width":1639,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b082e4f8ea4646cbb49cdb7127c6e574","type":"text","conversion_output":true,"text":"Laboratory abnormalities that Investigators consider to be clinically significant should be","text_display":"\n\nLaboratory abnormalities that Investigators consider to be clinically significant should be","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,417],[851,417],[851,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":607,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e039e453f3e451db05b203a4c2c2103","type":"text","conversion_output":true,"text":"reported as AEs (see Section 7.4.1).","text_display":" reported as AEs (see Section 7.4.1).","confidence":1,"confidence_rate":1},{"cnt":[[245,507],[1880,507],[1880,556],[245,556]],"region":{"top_left_x":244,"top_left_y":507,"width":1636,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"382fb11db84244868f6e162ddba3e053","type":"text","conversion_output":true,"text":"The best interest of the participating subject will always come before that of the trial.","text_display":"\n\nThe best interest of the participating subject will always come before that of the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,554],[1880,554],[1880,606],[245,606]],"region":{"top_left_x":244,"top_left_y":554,"width":1636,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d3e0226aa2746a19b6ea7124e26da2b","type":"text","conversion_output":true,"text":"Abnormalities of any safety laboratory analysis considered to represent a significant danger to","text_display":" Abnormalities of any safety laboratory analysis considered to represent a significant danger to","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1882,602],[1882,655],[245,655]],"region":{"top_left_x":244,"top_left_y":601,"width":1639,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"805ac4af6cb44ea49b8ca343487bf597","type":"text","conversion_output":true,"text":"the subject will lead to immediate discontinuation of the drug, and the Medical Responsible must","text_display":" the subject will lead to immediate discontinuation of the drug, and the Medical Responsible must","confidence":0.99560546875,"confidence_rate":0.9999563948558315},{"cnt":[[245,649],[685,649],[685,703],[245,703]],"region":{"top_left_x":244,"top_left_y":648,"width":442,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87952cc391ff43a3ba98d21e7cbdc4c2","type":"text","conversion_output":true,"text":"be informed immediately.","text_display":" be informed immediately.","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[1880,739],[1880,793],[245,793]],"region":{"top_left_x":244,"top_left_y":739,"width":1636,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48222c6c6e884a538dc44269e208f8e3","type":"text","conversion_output":true,"text":"In the event of significant abnormalities considered not to represent a danger, continuation of the","text_display":"\n\nIn the event of significant abnormalities considered not to represent a danger, continuation of the","confidence":0.9970703125,"confidence_rate":0.9999717889802962},{"cnt":[[245,786],[1880,786],[1880,840],[245,840]],"region":{"top_left_x":244,"top_left_y":786,"width":1636,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e6442d39c114a419abcc7d61949efc1","type":"text","conversion_output":true,"text":"drug may be allowed after discussion with the Medical Responsible. These subjects will be","text_display":" drug may be allowed after discussion with the Medical Responsible. These subjects will be","confidence":1,"confidence_rate":1},{"cnt":[[245,836],[1880,836],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":835,"width":1636,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"587e191357264e0db212a7df826992fd","type":"text","conversion_output":true,"text":"followed up with appropriate medical management until there is a return to normal or baseline","text_display":" followed up with appropriate medical management until there is a return to normal or baseline","confidence":1,"confidence_rate":1},{"cnt":[[245,883],[1500,883],[1500,935],[245,935]],"region":{"top_left_x":244,"top_left_y":883,"width":1256,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ad1341edac5488fbf6cc727aa59840f","type":"text","conversion_output":true,"text":"values, or until a clinical diagnosis of a trial-emergent illness is confirmed.","text_display":" values, or until a clinical diagnosis of a trial-emergent illness is confirmed.","confidence":1,"confidence_rate":1},{"cnt":[[241,969],[1841,969],[1841,1038],[241,1038]],"region":{"top_left_x":240,"top_left_y":968,"width":1602,"height":70},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc18a32f1b394a69ac5e8240345ccf58","type":"section_header","conversion_output":false,"children_ids":["3c2050029b714d27953c37d760b88a23"],"text":"","text_display":""},{"cnt":[[245,975],[1835,975],[1835,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":975,"width":1591,"height":59},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c2050029b714d27953c37d760b88a23","type":"text","conversion_output":true,"parent_id":"fc18a32f1b394a69ac5e8240345ccf58","text":"7.4.4 Vital Signs, Physical Examinations, and Other Assessments","text_display":"\n\n\\subsection*{7.4.4 Vital Signs, Physical Examinations, and Other Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[245,1070],[1880,1070],[1880,1121],[245,1121]],"region":{"top_left_x":244,"top_left_y":1069,"width":1636,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec9245046bed4311bbfe31e99388a399","type":"text","conversion_output":true,"text":"Physical examinations and measurement of height, weight, and vital signs (sitting systolic and","text_display":"\n\nPhysical examinations and measurement of height, weight, and vital signs (sitting systolic and","confidence":1,"confidence_rate":1},{"cnt":[[245,1119],[1880,1119],[1880,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1119,"width":1636,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19c1b24e71d348d49f964b147d304886","type":"text","conversion_output":true,"text":"diastolic blood pressure, heart rate, and body temperature) will be performed at the time points","text_display":" diastolic blood pressure, heart rate, and body temperature) will be performed at the time points","confidence":0.99609375,"confidence_rate":0.9999612492724017},{"cnt":[[245,1164],[668,1164],[668,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1164,"width":425,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02e5656452f04c2cb4b0800eee0bc23d","type":"text","conversion_output":true,"text":"specified in Appendix E.","text_display":" specified in Appendix E.","confidence":1,"confidence_rate":1},{"cnt":[[245,1257],[1880,1257],[1880,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1256,"width":1636,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7a294c8b0964695aa120f2ad2e0f874","type":"text","conversion_output":true,"text":"Standard 12-lead ECGs (reporting ventricular rate, PR, QRS, QT, and QTc intervals) will be","text_display":"\n\nStandard 12-lead ECGs (reporting ventricular rate, PR, QRS, QT, and QTc intervals) will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[1882,1302],[1882,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1301,"width":1639,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31675fa29801476299173582e7d357a0","type":"text","conversion_output":true,"text":"obtained at the time points specified in Appendix E. ECGs will be read centrally; procedures for","text_display":" obtained at the time points specified in Appendix E. ECGs will be read centrally; procedures for","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1354],[1880,1354],[1880,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1353,"width":1636,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa0152551a154aeab3f65c8b49a96c75","type":"text","conversion_output":true,"text":"transfer of data to the central reader are provided in the MOP. Original 12-lead ECG tracings","text_display":" transfer of data to the central reader are provided in the MOP. Original 12-lead ECG tracings","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1880,1401],[1880,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"327e6c80c94f49e69fd392aeaf9c941d","type":"text","conversion_output":true,"text":"will be retained in each individual subject's medical file. In case of abnormal results, a second","text_display":" will be retained in each individual subject's medical file. In case of abnormal results, a second","confidence":1,"confidence_rate":1},{"cnt":[[245,1448],[1880,1448],[1880,1500],[245,1500]],"region":{"top_left_x":244,"top_left_y":1448,"width":1636,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c22db664d1a741cf942b5e3705ba0670","type":"text","conversion_output":true,"text":"original will be provided to the Sponsor. ECGs can be repeated at the discretion of the","text_display":" original will be provided to the Sponsor. ECGs can be repeated at the discretion of the","confidence":0.9980475902557373,"confidence_rate":0.9999787576367025},{"cnt":[[245,1495],[771,1495],[771,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1495,"width":528,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"656c831cef3f4f838af5bca3baac39bb","type":"text","conversion_output":true,"text":"Investigator or co-Investigator.","text_display":" Investigator or co-Investigator.","confidence":1,"confidence_rate":1},{"cnt":[[245,1586],[1880,1586],[1880,1637],[245,1637]],"region":{"top_left_x":244,"top_left_y":1585,"width":1636,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b0d991cc4104e5f9d870705905e7575","type":"text","conversion_output":true,"text":"One of the trial's safety endpoints is the incidence of AIRs, defined as increase of pain by 30 mm","text_display":"\n\nOne of the trial's safety endpoints is the incidence of AIRs, defined as increase of pain by 30 mm","confidence":0.99853515625,"confidence_rate":0.9999859047370074},{"cnt":[[245,1633],[1880,1633],[1880,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfc086a9c58f4efba94f96c707eed8db","type":"text","conversion_output":true,"text":"on a \\(100- mm\\) VAS and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days","text_display":" on a \\(100- mm\\) VAS and a self-reported synovial fluid effusion (i.e., joint swelling) within 3 days","confidence":0.9946372479898855,"confidence_rate":0.9999511177113084},{"cnt":[[245,1680],[1880,1680],[1880,1734],[245,1734]],"region":{"top_left_x":244,"top_left_y":1680,"width":1636,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66c92a661d1e40d2a84707ec01ac2f17","type":"text","conversion_output":true,"text":"following i.a. injection (see Section 7.4.1.1). Subjects will use trial diaries to record maximum","text_display":" following i.a. injection (see Section 7.4.1.1). Subjects will use trial diaries to record maximum","confidence":0.998046875,"confidence_rate":0.9999808331754918},{"cnt":[[245,1729],[1882,1729],[1882,1781],[245,1781]],"region":{"top_left_x":244,"top_left_y":1729,"width":1639,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83f70488b26345c9b615016147a6656b","type":"text","conversion_output":true,"text":"levels of target knee pain experienced, using a \\(100- mm\\) VAS, and presence or absence of joint","text_display":" levels of target knee pain experienced, using a \\(100- mm\\) VAS, and presence or absence of joint","confidence":0.99755859375,"confidence_rate":0.9999762683268261},{"cnt":[[245,1779],[1880,1779],[1880,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1778,"width":1636,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1fb8a2fd6d04b7fa17b306faed3bcac","type":"text","conversion_output":true,"text":"swelling in the target knee. Completed diaries will be collected and reviewed at each visit, and","text_display":" swelling in the target knee. Completed diaries will be collected and reviewed at each visit, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[1880,1826],[1880,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1826,"width":1636,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99b9ccc794564816ba792e30fd75becd","type":"text","conversion_output":true,"text":"information will be transcribed to the CRFs following medical review. AIRs will be identified by","text_display":" information will be transcribed to the CRFs following medical review. AIRs will be identified by","confidence":1,"confidence_rate":1},{"cnt":[[245,1873],[1880,1873],[1880,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1873,"width":1636,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1827b176b20c41d79dd10136b36c4100","type":"text","conversion_output":true,"text":"the Sponsor based on the information about pain and swelling transcribed from the diaries to the","text_display":" the Sponsor based on the information about pain and swelling transcribed from the diaries to the","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[359,1921],[359,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":115,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed1b0a871f2e4298b945649b13f3cc0f","type":"text","conversion_output":true,"text":"CRFs.","text_display":" CRFs.","confidence":1,"confidence_rate":1},{"cnt":[[241,2007],[982,2007],[982,2069],[241,2069]],"region":{"top_left_x":240,"top_left_y":2006,"width":742,"height":63},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"deac7c74ec2e4fa2b3ca4cc640948902","type":"section_header","conversion_output":false,"children_ids":["b0d24496e17d4e65aec18d20f8d6bec1"],"text":"","text_display":""},{"cnt":[[245,2015],[978,2015],[978,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2015,"width":734,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0d24496e17d4e65aec18d20f8d6bec1","type":"text","conversion_output":true,"parent_id":"deac7c74ec2e4fa2b3ca4cc640948902","text":"7.5 Pharmacokinetics","text_display":"\n\n\\subsection*{7.5 Pharmacokinetics}","confidence":0.69482421875,"confidence_rate":0.9855416844435694},{"cnt":[[245,2105],[1674,2105],[1674,2159],[245,2159]],"region":{"top_left_x":244,"top_left_y":2105,"width":1430,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"340de3f5003e432a8dcdfc7c1eef2db5","type":"text","conversion_output":true,"text":"PK assessment will be performed for sprifermin/FGF-18 in serum and synovial fluid.","text_display":"\n\nPK assessment will be performed for sprifermin/FGF-18 in serum and synovial fluid.","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1880,2196],[1880,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2195,"width":1636,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"086d710ce7f7443f83fa887a71edb057","type":"text","conversion_output":true,"text":"Sprifermin differs from the endogenous FGF-18 molecule in that it is truncated (i.e., it has 170","text_display":"\nSprifermin differs from the endogenous FGF-18 molecule in that it is truncated (i.e., it has 170","confidence":0.9985356330871582,"confidence_rate":0.9999853457059158},{"cnt":[[245,2247],[1669,2247],[1669,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2247,"width":1426,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"488e24c001a14dfd99554453205a92af","type":"text","conversion_output":true,"text":"instead of 180 amino acids), it has a methionine extension, and it is not glycosylated.","text_display":" instead of 180 amino acids), it has a methionine extension, and it is not glycosylated.","confidence":0.99560546875,"confidence_rate":0.9999536409105637},{"cnt":[[245,2333],[1880,2333],[1880,2387],[245,2387]],"region":{"top_left_x":244,"top_left_y":2333,"width":1636,"height":54},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74af069403424b8b857c045d12d16e32","type":"text","conversion_output":true,"text":"Merck Serono internal Standard Operating Procedure HP01 describes the process for handling","text_display":"\n\nMerck Serono internal Standard Operating Procedure HP01 describes the process for handling","confidence":1,"confidence_rate":1},{"cnt":[[245,2383],[1880,2383],[1880,2434],[245,2434]],"region":{"top_left_x":244,"top_left_y":2382,"width":1636,"height":53},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7a2c372b6604e7cbec03ad23dd05877","type":"text","conversion_output":true,"text":"bioanalytical, PK, and pharmacodynamic (PD) data from double-blind clinical trials. To maintain","text_display":" bioanalytical, PK, and pharmacodynamic (PD) data from double-blind clinical trials. To maintain","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6eac589c7474452187b13499f847d197","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2544],[389,2542],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2541,"width":146,"height":46},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b7b78d14591c440e8aff52f57b6f8761","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd3517958dda456aa23730fde9aa8b39","type":"page_info","conversion_output":false,"text":"78/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2608],[1796,2608]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":109},"line":45,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"d9ff3550c74143d6bfc3e509580e23cb","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999186032298787}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-079","page":79,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a61bc0db99b4c7b90f7b918848fffad","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f543cf93714d42ccbf1d554ee9975a86","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c838e5ba5ee84b4285da6e1a1657b479","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fe8e0d06b2646cfaecf6c2b16981e2f","type":"text","conversion_output":true,"text":"the blind for PK data during this trial, the randomization list will only be provided to the PK","text_display":"\nthe blind for PK data during this trial, the randomization list will only be provided to the PK","confidence":1,"confidence_rate":1},{"cnt":[[245,327],[1592,327],[1592,380],[245,380]],"region":{"top_left_x":244,"top_left_y":326,"width":1348,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa3f39900c914bb2922a14a893542acc","type":"text","conversion_output":true,"text":"bioanalytical scientist or clinical trial team members after clinical database lock.","text_display":" bioanalytical scientist or clinical trial team members after clinical database lock.","confidence":1,"confidence_rate":1},{"cnt":[[241,412],[862,412],[862,483],[241,483]],"region":{"top_left_x":240,"top_left_y":412,"width":622,"height":72},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fad8517921a14862bcaef1e1155447b9","type":"section_header","conversion_output":false,"children_ids":["127f4cdc282c45ad82e66dff550a72a6"],"text":"","text_display":""},{"cnt":[[245,419],[855,419],[855,479],[245,479]],"region":{"top_left_x":244,"top_left_y":418,"width":612,"height":62},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"127f4cdc282c45ad82e66dff550a72a6","type":"text","conversion_output":true,"parent_id":"fad8517921a14862bcaef1e1155447b9","text":"7.5.1 Body Fluids","text_display":"\n\n\\subsection*{7.5.1 Body Fluids}","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1880,516],[1880,569],[245,569]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"058b1bac21f74dc0b1ef26f111f5e412","type":"text","conversion_output":true,"text":"Blood and synovial fluid samples for measurement of serum/synovial fluid sprifermin/FGF-18","text_display":"\n\nBlood and synovial fluid samples for measurement of serum/synovial fluid sprifermin/FGF-18","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,614],[245,614]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3d5448444824b2ba366ad23733f3bd8","type":"text","conversion_output":true,"text":"levels will be collected at the time points indicated in the schedule of assessments in Appendix","text_display":" levels will be collected at the time points indicated in the schedule of assessments in Appendix","confidence":0.9990236759185791,"confidence_rate":0.9999903287497746},{"cnt":[[243,606],[292,606],[292,657],[243,657]],"region":{"top_left_x":242,"top_left_y":605,"width":51,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d515d601e4d489aa4b8353179d6190f","type":"text","conversion_output":true,"text":"E.","text_display":" E.","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1880,700],[1880,752],[245,752]],"region":{"top_left_x":244,"top_left_y":700,"width":1636,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bb056d73efa4de1811b9f803cb33cfb","type":"text","conversion_output":true,"text":"Detailed description of sample preparation, labels, and shipments will be given in the MOP.","text_display":"\n\nDetailed description of sample preparation, labels, and shipments will be given in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[1884,748],[1884,801],[245,801]],"region":{"top_left_x":244,"top_left_y":747,"width":1641,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"055573c93ef144319bdf7995fa3a2c70","type":"text","conversion_output":true,"text":"Details of the assays such as the validation procedure and definition of lower limit of","text_display":" Details of the assays such as the validation procedure and definition of lower limit of","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[1880,795],[1880,849],[245,849]],"region":{"top_left_x":244,"top_left_y":794,"width":1636,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd57bb90da7d4b28ae1c69ef9ed14ec6","type":"text","conversion_output":true,"text":"quantification (LLOQ) will be described by the Sponsor/external laboratory in a separate","text_display":" quantification (LLOQ) will be described by the Sponsor/external laboratory in a separate","confidence":0.9990234375,"confidence_rate":0.9999894942525209},{"cnt":[[245,844],[1882,844],[1882,896],[245,896]],"region":{"top_left_x":244,"top_left_y":844,"width":1639,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47864e1324314418b31cab1cf7d01424","type":"text","conversion_output":true,"text":"analytical protocol. Some samples might be stored and used for additional analysis or for","text_display":" analytical protocol. Some samples might be stored and used for additional analysis or for","confidence":1,"confidence_rate":1},{"cnt":[[245,889],[672,889],[672,943],[245,943]],"region":{"top_left_x":244,"top_left_y":889,"width":429,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd1001960f9747e6808a4571945da63e","type":"text","conversion_output":true,"text":"validation of new assays.","text_display":" validation of new assays.","confidence":1,"confidence_rate":1},{"cnt":[[245,962],[1884,962],[1884,1016],[245,1016]],"region":{"top_left_x":244,"top_left_y":962,"width":1641,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4f563e9788545c1abc23da9f1dd0168","type":"text","conversion_output":true,"text":"- Blood samples for the measurement of sprifermin/FGF-18 serum levels will be collected at","text_display":"\n- Blood samples for the measurement of sprifermin/FGF-18 serum levels will be collected at","confidence":1,"confidence_rate":1},{"cnt":[[292,1010],[1583,1010],[1583,1063],[292,1063]],"region":{"top_left_x":292,"top_left_y":1009,"width":1292,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea4c4d5fecf94151affad6fa548ceee9","type":"text","conversion_output":true,"text":"pre-dose at Week 0 and thereafter at 2 hours after the last dose of each cycle.","text_display":" pre-dose at Week 0 and thereafter at 2 hours after the last dose of each cycle.","confidence":1,"confidence_rate":1},{"cnt":[[245,1083],[1882,1083],[1882,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1082,"width":1639,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b3fc78925bc404fbfd950971bd719bf","type":"text","conversion_output":true,"text":"- Synovial fluid for the measurement of sprifermin/FGF-18 levels will be aspirated under","text_display":"\n- Synovial fluid for the measurement of sprifermin/FGF-18 levels will be aspirated under","confidence":1,"confidence_rate":1},{"cnt":[[292,1130],[1882,1130],[1882,1184],[292,1184]],"region":{"top_left_x":292,"top_left_y":1130,"width":1591,"height":54},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42b3cffeed214896844fce6fe81d830c","type":"text","conversion_output":true,"text":"ultrasound guidance (32) prior to i.a. injection of sprifermin, as part of the i.a. injection","text_display":" ultrasound guidance (32) prior to i.a. injection of sprifermin, as part of the i.a. injection","confidence":0.9843957424163818,"confidence_rate":0.9998395303712299},{"cnt":[[292,1179],[1880,1179],[1880,1231],[292,1231]],"region":{"top_left_x":292,"top_left_y":1179,"width":1588,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6265ab0841654fdc86455efacad9fc2a","type":"text","conversion_output":true,"text":"procedure and using the same needle that will be used for IMP injection, as described in the","text_display":" procedure and using the same needle that will be used for IMP injection, as described in the","confidence":1,"confidence_rate":1},{"cnt":[[292,1229],[406,1229],[406,1274],[292,1274]],"region":{"top_left_x":292,"top_left_y":1228,"width":115,"height":47},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5f762c77bcd41ba96d7d7e9fbb51433","type":"text","conversion_output":true,"text":"MOP.","text_display":" MOP.","confidence":1,"confidence_rate":1},{"cnt":[[240,1378],[241,1311],[1240,1315],[1240,1381]],"region":{"top_left_x":240,"top_left_y":1311,"width":1000,"height":70},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1b87e896e444cb2bf4148de037b8bcf","type":"section_header","conversion_output":false,"children_ids":["2016fe8f7cc14ed19947b4817cbd3f10"],"text":"","text_display":""},{"cnt":[[245,1319],[1231,1319],[1231,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1319,"width":988,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2016fe8f7cc14ed19947b4817cbd3f10","type":"text","conversion_output":true,"parent_id":"a1b87e896e444cb2bf4148de037b8bcf","text":"7.5.2 Pharmacokinetic Calculations","text_display":"\n\n\\subsection*{7.5.2 Pharmacokinetic Calculations}","confidence":0.9990234375,"confidence_rate":0.999974948015144},{"cnt":[[245,1414],[1882,1414],[1882,1467],[245,1467]],"region":{"top_left_x":244,"top_left_y":1413,"width":1639,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ba3c089ded84843a97b568452b5709b","type":"text","conversion_output":true,"text":"The PK analysis will be performed under the responsibility of the Sponsor according to the","text_display":"\n\nThe PK analysis will be performed under the responsibility of the Sponsor according to the","confidence":1,"confidence_rate":1},{"cnt":[[245,1463],[1882,1463],[1882,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1463,"width":1639,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"462074508eef4b5faa307dfb36e85626","type":"text","conversion_output":true,"text":"Sponsor's appropriate standard operating procedures. Sprifermin/FGF-18 serum and synovial","text_display":" Sponsor's appropriate standard operating procedures. Sprifermin/FGF-18 serum and synovial","confidence":1,"confidence_rate":1},{"cnt":[[245,1508],[1880,1508],[1880,1562],[245,1562]],"region":{"top_left_x":244,"top_left_y":1508,"width":1636,"height":54},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90b5e4f67abc4ecf808f44b00ce5a40c","type":"text","conversion_output":true,"text":"fluid concentrations will be summarized at the time points shown in Appendix E. Details of the","text_display":" fluid concentrations will be summarized at the time points shown in Appendix E. Details of the","confidence":0.9970715045928955,"confidence_rate":0.9999703762787923},{"cnt":[[245,1558],[1880,1558],[1880,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1557,"width":1636,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc7b3681aaeb4535ae6c93f90db76bd4","type":"text","conversion_output":true,"text":"analysis and data displays will be provided in the Statistical Analysis Plan (SAP). Analytes to be","text_display":" analysis and data displays will be provided in the Statistical Analysis Plan (SAP). Analytes to be","confidence":1,"confidence_rate":1},{"cnt":[[245,1607],[1536,1607],[1536,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1607,"width":1293,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c450372aeeb494f91c416fdf2f50d00","type":"text","conversion_output":true,"text":"tested in this study will include serum and synovial fluid sprifermin/FGF-18.","text_display":" tested in this study will include serum and synovial fluid sprifermin/FGF-18.","confidence":1,"confidence_rate":1},{"cnt":[[241,1693],[1338,1693],[1338,1764],[241,1764]],"region":{"top_left_x":240,"top_left_y":1692,"width":1099,"height":72},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a976abb9fc1146dda408b3a2cda28823","type":"section_header","conversion_output":false,"children_ids":["05cb90d455f94029a19978fc2c4b391a"],"text":"","text_display":""},{"cnt":[[245,1697],[1330,1697],[1330,1757],[245,1757]],"region":{"top_left_x":244,"top_left_y":1697,"width":1086,"height":61},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05cb90d455f94029a19978fc2c4b391a","type":"text","conversion_output":true,"parent_id":"a976abb9fc1146dda408b3a2cda28823","text":"7.6 Biomarkers and Pharmacogenetics","text_display":"\n\n\\subsection*{7.6 Biomarkers and Pharmacogenetics}","confidence":0.95703125,"confidence_rate":0.9989026217120474},{"cnt":[[245,1792],[1880,1792],[1880,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1791,"width":1636,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab22190606b1464b88e7f88bce5d72a9","type":"text","conversion_output":true,"text":"Circulating biomarkers will be assessed for all subjects in serum, urine, and (if sample volumes","text_display":"\n\nCirculating biomarkers will be assessed for all subjects in serum, urine, and (if sample volumes","confidence":1,"confidence_rate":1},{"cnt":[[245,1841],[1880,1841],[1880,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1841,"width":1636,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b585f7e942e642a2887bb2f743aaa4ba","type":"text","conversion_output":true,"text":"permit) synovial fluid. Exploratory PGt analyses will be performed only for subjects who","text_display":" permit) synovial fluid. Exploratory PGt analyses will be performed only for subjects who","confidence":1,"confidence_rate":1},{"cnt":[[245,1891],[840,1891],[840,1940],[245,1940]],"region":{"top_left_x":244,"top_left_y":1890,"width":597,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3587fd7369954882a2d2c82603ffc982","type":"text","conversion_output":true,"text":"provide separate informed consent.","text_display":" provide separate informed consent.","confidence":1,"confidence_rate":1},{"cnt":[[241,1977],[1175,1977],[1175,2043],[241,2043]],"region":{"top_left_x":240,"top_left_y":1976,"width":936,"height":68},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7d8cffdc36c4ed69cec7c5c4513c2f3","type":"section_header","conversion_output":false,"children_ids":["aac85ee8ce324b6f9a3a7f854b2e1a2c"],"text":"","text_display":""},{"cnt":[[245,1981],[1171,1981],[1171,2039],[245,2039]],"region":{"top_left_x":244,"top_left_y":1980,"width":927,"height":59},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aac85ee8ce324b6f9a3a7f854b2e1a2c","type":"text","conversion_output":true,"parent_id":"f7d8cffdc36c4ed69cec7c5c4513c2f3","text":"7.6.1 Biomarkers to be Analyzed","text_display":"\n\n\\subsection*{7.6.1 Biomarkers to be Analyzed}","confidence":0.9990234375,"confidence_rate":0.9999728603780688},{"cnt":[[245,2075],[1880,2075],[1880,2127],[245,2127]],"region":{"top_left_x":244,"top_left_y":2075,"width":1636,"height":52},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6322faa9f12a44f698622de6493b29be","type":"text","conversion_output":true,"text":"Serological and urine biochemical markers of bone and joint tissue turnover will be evaluated.","text_display":"\n\nSerological and urine biochemical markers of bone and joint tissue turnover will be evaluated.","confidence":1,"confidence_rate":1},{"cnt":[[245,2125],[1880,2125],[1880,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2124,"width":1636,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc361ed169eb44b58f4f3d820300a753","type":"text","conversion_output":true,"text":"Potential biomarkers may include, but are not limited to: aggrecan chondroitin sulfate epitope","text_display":" Potential biomarkers may include, but are not limited to: aggrecan chondroitin sulfate epitope","confidence":1,"confidence_rate":1},{"cnt":[[245,2172],[1880,2172],[1880,2224],[245,2224]],"region":{"top_left_x":244,"top_left_y":2172,"width":1636,"height":52},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5742370e9c04286a6d07fc06bb9226c","type":"text","conversion_output":true,"text":"846 (CS846), II form of the propeptides from the N- terminus processed type II collagen","text_display":" 846 (CS846), II form of the propeptides from the N- terminus processed type II collagen","confidence":0.958984375,"confidence_rate":0.9995398806429427},{"cnt":[[245,2219],[1880,2219],[1880,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2219,"width":1636,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"668f053833d64a7680775184f41af7da","type":"text","conversion_output":true,"text":"(PIINP), propeptides from the C-terminus processed type II collagen (PIICP), and C-telopeptide","text_display":" (PIINP), propeptides from the C-terminus processed type II collagen (PIICP), and C-telopeptide","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[965,2269],[965,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2268,"width":721,"height":55},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5f1d8ab463542efbe5a2984bdcb6ea9","type":"text","conversion_output":true,"text":"cross-linking of type II collagen (CTX-II).","text_display":" cross-linking of type II collagen (CTX-II).","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"31bc9b766fce4b84bfdc0b807ca2a104","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2544],[390,2587],[245,2589]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":46},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f00d67030e9147ee9deefd0e8d659f86","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a9d314d4e4c46cb81a4cbab94ec0889","type":"page_info","conversion_output":false,"text":"79/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-080","page":80,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80d6960530904a55bbf1e3b63bb938a0","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe573997aa43405eb5070dfae04bde5c","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d76c238d306b4d42aad7e82ed5080856","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1886,279],[1886,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1643,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90a3a12f3a714db7b13cda360ca5ddb8","type":"text","conversion_output":true,"text":"Measurement of biomarkers in synovial fluid is also foreseen. However, if the quantity of","text_display":"\n\nMeasurement of biomarkers in synovial fluid is also foreseen. However, if the quantity of","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1884,329],[1884,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1641,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fff46f85c24d4e4fb6e89551f700cbff","type":"text","conversion_output":true,"text":"synovial fluid collected is not sufficient to permit both PK and biomarker measurement, priority","text_display":" synovial fluid collected is not sufficient to permit both PK and biomarker measurement, priority","confidence":1,"confidence_rate":1},{"cnt":[[245,378],[587,378],[587,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":343,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"082289e344f24b6b96d54444a3850862","type":"text","conversion_output":true,"text":"will be given to PK.","text_display":" will be given to PK.","confidence":1,"confidence_rate":1},{"cnt":[[245,466],[1880,466],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1636,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25c76db5c14d47269de1725487f03386","type":"text","conversion_output":true,"text":"Samples will be stored for up to 5 years after trial completion under the Sponsor's responsibility.","text_display":"\n\nSamples will be stored for up to 5 years after trial completion under the Sponsor's responsibility.","confidence":0.9941456306260079,"confidence_rate":0.9999451269880746},{"cnt":[[245,516],[1880,516],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e5dd857423546e5aeb8c530bbf67337","type":"text","conversion_output":true,"text":"During this time, it is possible that the samples will be re-analyzed by the Sponsor or its","text_display":" During this time, it is possible that the samples will be re-analyzed by the Sponsor or its","confidence":1,"confidence_rate":1},{"cnt":[[245,561],[1880,561],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":560,"width":1636,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd66614367f94ef1a156c6a4a7dba774","type":"text","conversion_output":true,"text":"designee. This may include analyses for newly identified markers and/or a repeat of the original","text_display":" designee. This may include analyses for newly identified markers and/or a repeat of the original","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1880,610],[1880,660],[245,660]],"region":{"top_left_x":244,"top_left_y":610,"width":1636,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"492d18a5aa94421aa6ed3c3316b744e6","type":"text","conversion_output":true,"text":"analysis with newer improved technologies. After this period of 5 years, either the samples will","text_display":" analysis with newer improved technologies. After this period of 5 years, either the samples will","confidence":1,"confidence_rate":1},{"cnt":[[245,657],[1882,657],[1882,707],[245,707]],"region":{"top_left_x":244,"top_left_y":657,"width":1639,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f067d038265b49949c912133299e156e","type":"text","conversion_output":true,"text":"be destroyed or fully anonymized or new IEC/IRB approval will be requested to keep them for","text_display":" be destroyed or fully anonymized or new IEC/IRB approval will be requested to keep them for","confidence":1,"confidence_rate":1},{"cnt":[[245,705],[597,705],[597,758],[245,758]],"region":{"top_left_x":244,"top_left_y":704,"width":354,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b441030a44a24739a30272c47259b3dd","type":"text","conversion_output":true,"text":"an additional period.","text_display":" an additional period.","confidence":1,"confidence_rate":1},{"cnt":[[241,791],[1424,791],[1424,862],[241,862]],"region":{"top_left_x":240,"top_left_y":790,"width":1185,"height":72},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6db9326b66d4498976f290d3e128074","type":"section_header","conversion_output":false,"children_ids":["f86bcd639a814ac999d7f59cc405d198"],"text":"","text_display":""},{"cnt":[[245,795],[1420,795],[1420,855],[245,855]],"region":{"top_left_x":244,"top_left_y":794,"width":1177,"height":62},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f86bcd639a814ac999d7f59cc405d198","type":"text","conversion_output":true,"parent_id":"a6db9326b66d4498976f290d3e128074","text":"7.6.2 Body Fluids for Biomarker Assessment","text_display":"\n\n\\subsection*{7.6.2 Body Fluids for Biomarker Assessment}","confidence":1,"confidence_rate":1},{"cnt":[[245,889],[1880,889],[1880,943],[245,943]],"region":{"top_left_x":244,"top_left_y":889,"width":1636,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05dcae9173184ad69f3d8581edb0dd81","type":"text","conversion_output":true,"text":"Blood and urine samples for systemic biomarker assessment will be collected at the time points","text_display":"\n\nBlood and urine samples for systemic biomarker assessment will be collected at the time points","confidence":1,"confidence_rate":1},{"cnt":[[245,941],[1880,941],[1880,990],[245,990]],"region":{"top_left_x":244,"top_left_y":941,"width":1636,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d24149bbd3b4864816366accaed9527","type":"text","conversion_output":true,"text":"specified in Appendix E. For time points where IMP injections are administered, samples will be","text_display":" specified in Appendix E. For time points where IMP injections are administered, samples will be","confidence":1,"confidence_rate":1},{"cnt":[[245,988],[1760,988],[1760,1040],[245,1040]],"region":{"top_left_x":244,"top_left_y":988,"width":1516,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1256819eef674e1db01524659c0557eb","type":"text","conversion_output":true,"text":"collected pre-dose. For urine collection, second morning void samples should be obtained.","text_display":" collected pre-dose. For urine collection, second morning void samples should be obtained.","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1880,1079],[1880,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1078,"width":1636,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a84a6226dee4a86968af34cf4d2acd5","type":"text","conversion_output":true,"text":"Synovial fluid samples will be collected at the time points specified in Appendix E. These","text_display":"\n\nSynovial fluid samples will be collected at the time points specified in Appendix E. These","confidence":0.9956088066101074,"confidence_rate":0.9999536761993237},{"cnt":[[245,1126],[1880,1126],[1880,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1125,"width":1636,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"690eb83687194d65b03d4ef9f75b2142","type":"text","conversion_output":true,"text":"samples will be taken just before injection of the IMP as described in the MOP, as part of the i.a.","text_display":" samples will be taken just before injection of the IMP as described in the MOP, as part of the i.a.","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1880,1173],[1880,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1636,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"218e59e1260a440cb7b2804aeeb84019","type":"text","conversion_output":true,"text":"injection procedure and using the same needle that will be used for IMP injection. If sample","text_display":" injection procedure and using the same needle that will be used for IMP injection. If sample","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1880,1220],[1880,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1220,"width":1636,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b8b2d2053b745e6be75063f25a42704","type":"text","conversion_output":true,"text":"volume permits, biomarkers will be analyzed in the samples collected at Week 0/Visit 2,","text_display":" volume permits, biomarkers will be analyzed in the samples collected at Week 0/Visit 2,","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1880,1268],[1880,1319],[245,1319]],"region":{"top_left_x":244,"top_left_y":1267,"width":1636,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff17747aa23449e0a37a6abee454adad","type":"text","conversion_output":true,"text":"Week 28/Visit 9, Week 54/Visit 14 and Week 80/Visit 19; otherwise, priority will be given to","text_display":" Week 28/Visit 9, Week 54/Visit 14 and Week 80/Visit 19; otherwise, priority will be given to","confidence":1,"confidence_rate":1},{"cnt":[[243,1313],[316,1313],[316,1364],[243,1364]],"region":{"top_left_x":242,"top_left_y":1312,"width":74,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"adf7226d79ce4d759817fc3412fdcc21","type":"text","conversion_output":true,"text":"PK.","text_display":" PK.","confidence":1,"confidence_rate":1},{"cnt":[[245,1405],[1880,1405],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46625b56d2a64c6e90a00aeb936b5207","type":"text","conversion_output":true,"text":"Instructions for the preparation and handling of blood samples for assessment of circulating","text_display":"\n\nInstructions for the preparation and handling of blood samples for assessment of circulating","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,1457],[827,1457],[827,1506],[245,1506]],"region":{"top_left_x":244,"top_left_y":1456,"width":584,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4759b08bbbc14ff39e7c07c44451d94c","type":"text","conversion_output":true,"text":"proteins can be found in the MOP.","text_display":" proteins can be found in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[241,1543],[988,1543],[988,1609],[241,1609]],"region":{"top_left_x":240,"top_left_y":1542,"width":749,"height":68},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"baa3076d04ed4481b5bbb8275b5cafc7","type":"section_header","conversion_output":false,"children_ids":["5e19dbb65cf7456ba60e1380034822e2"],"text":"","text_display":""},{"cnt":[[245,1547],[982,1547],[982,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1546,"width":738,"height":59},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e19dbb65cf7456ba60e1380034822e2","type":"text","conversion_output":true,"parent_id":"baa3076d04ed4481b5bbb8275b5cafc7","text":"7.6.3 Pharmacogenetics","text_display":"\n\n\\subsection*{7.6.3 Pharmacogenetics}","confidence":0.99951171875,"confidence_rate":0.9999819112562659},{"cnt":[[245,1641],[1880,1641],[1880,1695],[245,1695]],"region":{"top_left_x":244,"top_left_y":1641,"width":1636,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"016db538179a4c4abdda81f155495b0f","type":"text","conversion_output":true,"text":"Exploratory analyses are planned to identify potential associations of genetic variations with","text_display":"\n\nExploratory analyses are planned to identify potential associations of genetic variations with","confidence":1,"confidence_rate":1},{"cnt":[[245,1693],[1171,1693],[1171,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1692,"width":927,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0473f1d4a7c24f66954da1476f52cb24","type":"text","conversion_output":true,"text":"safety events, drug response, and/or treatment efficacy.","text_display":" safety events, drug response, and/or treatment efficacy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1779],[1882,1779],[1882,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1778,"width":1639,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00490e9e6fdd4c5e8d7efa31e585b734","type":"text","conversion_output":true,"text":"All subjects who are enrolled in the trial will be eligible to participate in the optional PGt","text_display":"\n\nAll subjects who are enrolled in the trial will be eligible to participate in the optional PGt","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[1880,1826],[1880,1878],[245,1878]],"region":{"top_left_x":244,"top_left_y":1826,"width":1636,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac37e5815eb94728856ede640d963829","type":"text","conversion_output":true,"text":"analysis (except in countries where collection of PGt samples is not allowed). Participation is","text_display":" analysis (except in countries where collection of PGt samples is not allowed). Participation is","confidence":0.961462727165781,"confidence_rate":0.9996070824123124},{"cnt":[[245,1876],[1880,1876],[1880,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1875,"width":1636,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd7bacb856104b3081ce8a338ac32d64","type":"text","conversion_output":true,"text":"optional, and the subjects who choose to participate will need to sign a specific PGt ICF (see","text_display":" optional, and the subjects who choose to participate will need to sign a specific PGt ICF (see","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[466,1925],[466,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1925,"width":223,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf7a1cabbd2448ba860c5b1e1f8a7b33","type":"text","conversion_output":true,"text":"Section 9.2).","text_display":" Section 9.2).","confidence":1,"confidence_rate":1},{"cnt":[[245,2013],[1880,2013],[1880,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2013,"width":1636,"height":52},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d22b4b52bc542719cf82ac9531a96d1","type":"text","conversion_output":true,"text":"The results of the genetic analysis are for research purposes only. The results of the genetic tests","text_display":"\n\nThe results of the genetic analysis are for research purposes only. The results of the genetic tests","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,2062],[1880,2062],[1880,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2062,"width":1636,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdf53c6cbebb4df28bd532f1ff415890","type":"text","conversion_output":true,"text":"will not be made available to the subject, members of his/her family, his/her personal physician,","text_display":" will not be made available to the subject, members of his/her family, his/her personal physician,","confidence":1,"confidence_rate":1},{"cnt":[[245,2110],[1179,2110],[1179,2159],[245,2159]],"region":{"top_left_x":244,"top_left_y":2109,"width":936,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c5206305c8a4345ae7f7c0782accfda","type":"text","conversion_output":true,"text":"or other third parties, except as specified in Section 9.3.","text_display":" or other third parties, except as specified in Section 9.3.","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1880,2196],[1880,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2195,"width":1636,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"004962291f544bc595f9b163e4d26078","type":"text","conversion_output":true,"text":"Once a subject has given appropriate consent, a single blood sample for PGt analysis will be","text_display":"\n\nOnce a subject has given appropriate consent, a single blood sample for PGt analysis will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2247],[1794,2247],[1794,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2247,"width":1550,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf6c55855cdc428fbaa8a0e43b3ceb27","type":"text","conversion_output":true,"text":"collected; this sample can be taken at any trial visit (including pre-dose at the baseline visit).","text_display":" collected; this sample can be taken at any trial visit (including pre-dose at the baseline visit).","confidence":1,"confidence_rate":1},{"cnt":[[245,2338],[1880,2338],[1880,2387],[245,2387]],"region":{"top_left_x":244,"top_left_y":2337,"width":1636,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd04920dcc35425cbd5baae8251742b1","type":"text","conversion_output":true,"text":"Instructions for the preparation and handling of blood samples for PGt analysis can be found in","text_display":"\n\nInstructions for the preparation and handling of blood samples for PGt analysis can be found in","confidence":1,"confidence_rate":1},{"cnt":[[245,2385],[415,2385],[415,2430],[245,2430]],"region":{"top_left_x":244,"top_left_y":2384,"width":171,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98e4e0ef3f0148a0b19deabc1e115f4d","type":"text","conversion_output":true,"text":"the MOP.","text_display":" the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4a965f85b46142169388cd3b6880450f","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"97f64041cb0d47f3b75583130aa67895","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d147364b89f94aed85db95d5b31b0b45","type":"page_info","conversion_output":false,"text":"80/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2610],[1796,2610]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":111},"line":44,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"e0fb1fd107994979bd8313f6184743d4","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999186032298787}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-081","page":81,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73f45e2c259f430495302b90f862ad1a","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38fab848f2ee4b95bea8504d0c042cc2","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f569966ce224477aa9dac306f18b0d5","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"537d86bc56264800ad6622b49b2b0a2f","type":"text","conversion_output":true,"text":"Samples will be stored for up to 5 years after trial completion under the Sponsor's responsibility.","text_display":"\n\nSamples will be stored for up to 5 years after trial completion under the Sponsor's responsibility.","confidence":0.9731817245483398,"confidence_rate":0.9997459720185122},{"cnt":[[245,329],[1880,329],[1880,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1636,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27f5c278a88349c98bb6089cfa2aaee6","type":"text","conversion_output":true,"text":"During this time, it is possible that the samples will be re-analyzed by the Sponsor or its","text_display":" During this time, it is possible that the samples will be re-analyzed by the Sponsor or its","confidence":1,"confidence_rate":1},{"cnt":[[245,378],[1880,378],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":1636,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b907542ff847419e8f63e77e53282e17","type":"text","conversion_output":true,"text":"designee. This may include analyses for newly identified markers and/or a repeat of the original","text_display":" designee. This may include analyses for newly identified markers and/or a repeat of the original","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83a93c94def548dda34313c6198d25c0","type":"text","conversion_output":true,"text":"analysis with newer improved technologies. After this period of 5 years, either samples will be","text_display":" analysis with newer improved technologies. After this period of 5 years, either samples will be","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1880,473],[1880,522],[245,522]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23c75d21e50349e48c9328e14854fa0e","type":"text","conversion_output":true,"text":"destroyed or fully anonymized or new IEC/IRB approval to keep the samples for an additional","text_display":" destroyed or fully anonymized or new IEC/IRB approval to keep the samples for an additional","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[664,520],[664,574],[245,574]],"region":{"top_left_x":244,"top_left_y":519,"width":420,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9db10f613bf41d1ba722ec17b7eb621","type":"text","conversion_output":true,"text":"period will be requested.","text_display":" period will be requested.","confidence":1,"confidence_rate":1},{"cnt":[[241,608],[1003,608],[1003,668],[241,668]],"region":{"top_left_x":240,"top_left_y":608,"width":764,"height":61},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83849e59ff6f4766946f761225acc295","type":"section_header","conversion_output":false,"children_ids":["1be80adf12234e5cb62fbeb642f80891"],"text":"","text_display":""},{"cnt":[[245,614],[999,614],[999,660],[245,660]],"region":{"top_left_x":244,"top_left_y":614,"width":756,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1be80adf12234e5cb62fbeb642f80891","type":"text","conversion_output":true,"parent_id":"83849e59ff6f4766946f761225acc295","text":"7.7 Other Assessments","text_display":"\n\n\\subsection*{7.7 Other Assessments}","confidence":0.9970703125,"confidence_rate":0.9998871606962645},{"cnt":[[243,707],[1888,703],[1889,818],[243,822]],"region":{"top_left_x":242,"top_left_y":703,"width":1647,"height":119},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfdbb49cf72e4635883ce278cdcf6434","type":"section_header","conversion_output":false,"children_ids":["88a6efe83fe84bd784c4fb257e4eced5","d0401eff67c5451fb9c556253e934f99"],"text":"","text_display":""},{"cnt":[[247,709],[1884,709],[1884,767],[247,767]],"region":{"top_left_x":247,"top_left_y":708,"width":1638,"height":59},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88a6efe83fe84bd784c4fb257e4eced5","type":"text","conversion_output":true,"parent_id":"bfdbb49cf72e4635883ce278cdcf6434","text":"7.7.1 Knee Injury and Osteoarthritis Outcome Score - Quality of","text_display":"\n\n\\subsection*{7.7.1 Knee Injury and Osteoarthritis Outcome Score - Quality of","confidence":1,"confidence_rate":1},{"cnt":[[593,767],[1334,767],[1334,821],[593,821]],"region":{"top_left_x":592,"top_left_y":766,"width":743,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0401eff67c5451fb9c556253e934f99","type":"text","conversion_output":true,"parent_id":"bfdbb49cf72e4635883ce278cdcf6434","text":"Life and Symptom Index Subscales","text_display":" Life and Symptom Index Subscales}","confidence":1,"confidence_rate":1},{"cnt":[[245,862],[1880,862],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":861,"width":1636,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78f14eafa08c45c1a39e5462a5f2a252","type":"text","conversion_output":true,"text":"The KOOS (33) is a knee-specific questionnaire designed to evaluate both short-term and long-","text_display":"\n\nThe KOOS (33) is a knee-specific questionnaire designed to evaluate both short-term and long","confidence":0.9888100116718306,"confidence_rate":0.999885179375481},{"cnt":[[245,907],[1880,907],[1880,958],[245,958]],"region":{"top_left_x":244,"top_left_y":906,"width":1636,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f331647e7b6a4b6f9b446d99ee652460","type":"text","conversion_output":true,"text":"term consequences of knee injury, including OA; it is intended for use in knee injury potentially","text_display":"term consequences of knee injury, including OA; it is intended for use in knee injury potentially","confidence":1,"confidence_rate":1},{"cnt":[[245,956],[1880,956],[1880,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":956,"width":1636,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5161030311e34342b828abbd747781b5","type":"text","conversion_output":true,"text":"leading to post-traumatic OA or in primary OA. It consists of 42 items grouped into 5 subscales:","text_display":" leading to post-traumatic OA or in primary OA. It consists of 42 items grouped into 5 subscales:","confidence":0.7482919692993164,"confidence_rate":0.9972937428901925},{"cnt":[[245,1005],[1880,1005],[1880,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1005,"width":1636,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4cd33e825a20454c957c9f9d5c9e371d","type":"text","conversion_output":true,"text":"pain, other symptoms (including swelling, restricted range of motion, and mechanical","text_display":" pain, other symptoms (including swelling, restricted range of motion, and mechanical","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1880,1053],[1880,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1052,"width":1636,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c85f21d4c62748988c01e063c3c167ba","type":"text","conversion_output":true,"text":"symptoms), function in daily living (ADL), function in sport and recreation (i.e., impact on more","text_display":" symptoms), function in daily living (ADL), function in sport and recreation (i.e., impact on more","confidence":1,"confidence_rate":1},{"cnt":[[245,1100],[1880,1100],[1880,1149],[245,1149]],"region":{"top_left_x":244,"top_left_y":1100,"width":1636,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67a2999b3b544053aac04b1066698b9a","type":"text","conversion_output":true,"text":"demanding physical activities), and impact on quality of life (including awareness of the knee","text_display":" demanding physical activities), and impact on quality of life (including awareness of the knee","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1880,1147],[1880,1199],[245,1199]],"region":{"top_left_x":244,"top_left_y":1147,"width":1636,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88ff222a34ed428f834e4941d81ae453","type":"text","conversion_output":true,"text":"condition and changes in lifestyle). The subscales are scored separately; each yields a score","text_display":" condition and changes in lifestyle). The subscales are scored separately; each yields a score","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1884,1195],[1884,1246],[245,1246]],"region":{"top_left_x":244,"top_left_y":1194,"width":1641,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20b28edcdc954a138cd2fe66b81755dd","type":"text","conversion_output":true,"text":"between 0 and 100, with 0 representing extreme knee problems and 100 representing absence of","text_display":" between 0 and 100, with 0 representing extreme knee problems and 100 representing absence of","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,1244],[1880,1244],[1880,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1243,"width":1636,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72c32823d63a41dd8b5cd9ada5ceabbc","type":"text","conversion_output":true,"text":"problems. The 42 items of the complete KOOS include the 24 items of the WOMAC","text_display":" problems. The 42 items of the complete KOOS include the 24 items of the WOMAC","confidence":0.99755859375,"confidence_rate":0.9999722232114437},{"cnt":[[245,1293],[1880,1293],[1880,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1293,"width":1636,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"105866b19ba5463f9e904fc0bf630de5","type":"text","conversion_output":true,"text":"Osteoarthritis Index (26), the most frequently used patient-assessed measure of treatment effect","text_display":" Osteoarthritis Index (26), the most frequently used patient-assessed measure of treatment effect","confidence":1,"confidence_rate":1},{"cnt":[[245,1341],[1867,1341],[1867,1390],[245,1390]],"region":{"top_left_x":244,"top_left_y":1340,"width":1623,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24b2806e92384159ac105d55f4283c1d","type":"text","conversion_output":true,"text":"in OA. In this study, there will be no duplication of questions from the WOMAC and the KOOS.","text_display":" in OA. In this study, there will be no duplication of questions from the WOMAC and the KOOS.","confidence":0.9677734375,"confidence_rate":0.999662353187999},{"cnt":[[245,1431],[1876,1431],[1876,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1430,"width":1632,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b51a0228e9e4243aefb32bd76699e8e","type":"text","conversion_output":true,"text":"The KOOS has been validated for use in patients undergoing total knee replacement for OA.","text_display":"\n\nThe KOOS has been validated for use in patients undergoing total knee replacement for OA.","confidence":0.99951171875,"confidence_rate":0.9999948042635181},{"cnt":[[245,1478],[1880,1478],[1880,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1478,"width":1636,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1b1df4875c9491e92bb178a7bade8dc","type":"text","conversion_output":true,"text":"Content validity in this patient group was assessed before surgery by asking patients to rate the","text_display":" Content validity in this patient group was assessed before surgery by asking patients to rate the","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1880,1525],[1880,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1525,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ccd89b3002649a099269cd10a5afdbb","type":"text","conversion_output":true,"text":"importance of improvement in each of the KOOS subscales. Notably, larger effect sizes were","text_display":" importance of improvement in each of the KOOS subscales. Notably, larger effect sizes were","confidence":0.99853515625,"confidence_rate":0.9999845694066055},{"cnt":[[245,1573],[1880,1573],[1880,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1572,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7395aa9346ac465f8fd6ae991bf711c8","type":"text","conversion_output":true,"text":"seen with the KOOS compared to the WOMAC following TKR for severe knee OA (33),(34). A","text_display":" seen with the KOOS compared to the WOMAC following TKR for severe knee OA (33),(34). A","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[245,1620],[1880,1620],[1880,1671],[245,1671]],"region":{"top_left_x":244,"top_left_y":1619,"width":1636,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c1268cb2d2e46ca83c9fe43bc88e71e","type":"text","conversion_output":true,"text":"change of 10 points in KOOS score has been proposed as representing clinically meaningful","text_display":" change of 10 points in KOOS score has been proposed as representing clinically meaningful","confidence":0.998535871389322,"confidence_rate":0.9999848949440379},{"cnt":[[245,1669],[1880,1669],[1880,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1669,"width":1636,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da9fbcebfbc845fdaf04debc2eb2c366","type":"text","conversion_output":true,"text":"difference based on experience with the WOMAC; however, the minimal perceptible clinical","text_display":" difference based on experience with the WOMAC; however, the minimal perceptible clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,1719],[1880,1719],[1880,1768],[245,1768]],"region":{"top_left_x":244,"top_left_y":1718,"width":1636,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60bd798f95c746b79d53fdc19d453a76","type":"text","conversion_output":true,"text":"improvement (MPCI; defined as the change in score associated with the smallest change in","text_display":" improvement (MPCI; defined as the change in score associated with the smallest change in","confidence":1,"confidence_rate":1},{"cnt":[[245,1766],[1747,1766],[1747,1815],[245,1815]],"region":{"top_left_x":244,"top_left_y":1766,"width":1503,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"265b0957a3244b2ca3874d094d0d0d3a","type":"text","conversion_output":true,"text":"health status detectable by the patient) has not been formally assessed for the KOOS (33).","text_display":" health status detectable by the patient) has not been formally assessed for the KOOS (33).","confidence":1,"confidence_rate":1},{"cnt":[[245,1856],[1880,1856],[1880,1904],[245,1904]],"region":{"top_left_x":244,"top_left_y":1856,"width":1636,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a251efe329ba4f18a9ce1c5a7b883bae","type":"text","conversion_output":true,"text":"In this trial, the KOOS quality of life subscale will be evaluated at the same time points as the","text_display":"\n\nIn this trial, the KOOS quality of life subscale will be evaluated at the same time points as the","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1880,1904],[1880,1953],[245,1953]],"region":{"top_left_x":244,"top_left_y":1903,"width":1636,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01e379cefcbf45a3822751d943d0d625","type":"text","conversion_output":true,"text":"WOMAC, as a complement to the more general MOS SF-36 (see below). The KOOS Symptom","text_display":" WOMAC, as a complement to the more general MOS SF-36 (see below). The KOOS Symptom","confidence":1,"confidence_rate":1},{"cnt":[[245,1951],[1884,1951],[1884,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1950,"width":1641,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fae466e314c48429db9e57ecfb03bfe","type":"text","conversion_output":true,"text":"Index will also be completed at the same time points for correlation with the other indicators of","text_display":" Index will also be completed at the same time points for correlation with the other indicators of","confidence":1,"confidence_rate":1},{"cnt":[[245,1998],[1016,1998],[1016,2047],[245,2047]],"region":{"top_left_x":244,"top_left_y":1998,"width":773,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56b4e104d58f43139d844565ab49f949","type":"text","conversion_output":true,"text":"tibiofemoral cartilage loss (e.g., MRI, X-ray).","text_display":" tibiofemoral cartilage loss (e.g., MRI, X-ray).","confidence":1,"confidence_rate":1},{"cnt":[[243,2085],[1884,2083],[1884,2206],[243,2209]],"region":{"top_left_x":242,"top_left_y":2082,"width":1643,"height":128},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e415cbdf154b4d238fb3bdbf5aea36b9","type":"section_header","conversion_output":false,"children_ids":["ad1acf732ad748bc81c29b351a04538d","57d3f8101d3a40ada7189cb8dde90456"],"text":"","text_display":""},{"cnt":[[245,2088],[1880,2088],[1880,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2088,"width":1636,"height":59},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad1acf732ad748bc81c29b351a04538d","type":"text","conversion_output":true,"parent_id":"e415cbdf154b4d238fb3bdbf5aea36b9","text":"7.7.2 Medical Outcomes Study Short Form-36 General Health","text_display":"\n\n\\subsection*{7.7.2 Medical Outcomes Study Short Form-36 General Health","confidence":1,"confidence_rate":1},{"cnt":[[593,2148],[750,2148],[750,2202],[593,2202]],"region":{"top_left_x":592,"top_left_y":2148,"width":158,"height":55},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57d3f8101d3a40ada7189cb8dde90456","type":"text","conversion_output":true,"parent_id":"e415cbdf154b4d238fb3bdbf5aea36b9","text":"Survey","text_display":" Survey}","confidence":1,"confidence_rate":1},{"cnt":[[245,2241],[1880,2241],[1880,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2240,"width":1636,"height":53},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6983aa52c3d4e8ab395991373c427c0","type":"text","conversion_output":true,"text":"The MOS SF-36 (version 2.0) is a multi-purpose questionnaire that measures general health","text_display":"\n\nThe MOS SF-36 (version 2.0) is a multi-purpose questionnaire that measures general health","confidence":1,"confidence_rate":1},{"cnt":[[245,2290],[1880,2290],[1880,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2290,"width":1636,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d61b88e587564507ac556956654db977","type":"text","conversion_output":true,"text":"status and QOL, is not knee specific, and is the single PRO measure included to assess the","text_display":" status and QOL, is not knee specific, and is the single PRO measure included to assess the","confidence":1,"confidence_rate":1},{"cnt":[[245,2338],[1880,2338],[1880,2387],[245,2387]],"region":{"top_left_x":244,"top_left_y":2337,"width":1636,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a70b7987d2f46efb236af9176023bc6","type":"text","conversion_output":true,"text":"overall status of the patient. It consists of 36 items that evaluate 8 dimensions of health: physical","text_display":" overall status of the patient. It consists of 36 items that evaluate 8 dimensions of health: physical","confidence":0.9970715045928955,"confidence_rate":0.9999738147014133},{"cnt":[[245,2385],[1880,2385],[1880,2436],[245,2436]],"region":{"top_left_x":244,"top_left_y":2384,"width":1636,"height":53},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4884d2fbe124fbdb3e0d3fee0619c5b","type":"text","conversion_output":true,"text":"function, bodily pain, general mental health, vitality (energy and fatigue), social function,","text_display":" function, bodily pain, general mental health, vitality (energy and fatigue), social function,","confidence":1,"confidence_rate":1},{"cnt":[[245,2432],[1880,2432],[1880,2486],[245,2486]],"region":{"top_left_x":244,"top_left_y":2432,"width":1636,"height":54},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc3a5ba6f9d742b8830a741fb9749b83","type":"text","conversion_output":true,"text":"physical role (role limitations due to physical health), emotional role (role limitations due to","text_display":" physical role (role limitations due to physical health), emotional role (role limitations due to","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":46,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"35fd5ee1f69148ad8ea8dd28da200045","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":47,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a5c4d267ea2e4b5bb0e8e1cc1e0a31c6","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968649},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34958747d70a40cd85f6d85e0e99dd7d","type":"page_info","conversion_output":false,"text":"81/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-082","page":82,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76881ba06a3348f9982de1979ac75542","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a61efb6b3fba4cd7a9026497edde73a6","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9cb142ba9db490daa4f4e6774022116","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a14afe4bffa49b6bbe292ba172c7ed1","type":"text","conversion_output":true,"text":"personal or emotional problems), and general health perceptions. Scores for the 8","text_display":"\npersonal or emotional problems), and general health perceptions. Scores for the 8","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1880,329],[1880,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1636,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f35f5dd92fa6420ebfd1cf2c2a7215cc","type":"text","conversion_output":true,"text":"dimensions/subscales range from 0 to 100, with higher scores representing better QOL. The","text_display":" dimensions/subscales range from 0 to 100, with higher scores representing better QOL. The","confidence":0.97607421875,"confidence_rate":0.9997503749588464},{"cnt":[[245,374],[1882,374],[1882,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1639,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"334457d739a441e989fa5ecae39dd16e","type":"text","conversion_output":true,"text":"MOS SF-36 is a generic measure as opposed to one targeting a specific age group, disease, or","text_display":" MOS SF-36 is a generic measure as opposed to one targeting a specific age group, disease, or","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,424],[1880,421],[1880,475],[245,477]],"region":{"top_left_x":244,"top_left_y":421,"width":1636,"height":56},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5af316a1978447c1b9a21d61ca148f71","type":"text","conversion_output":true,"text":"treatment. Accordingly, it has proven useful in surveys of general and specific populations,","text_display":" treatment. Accordingly, it has proven useful in surveys of general and specific populations,","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1880,473],[1880,522],[245,522]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28e4fa3443434df3bd65f42fd5717bd8","type":"text","conversion_output":true,"text":"comparing the relative burden of different diseases, and examining the health benefits associated","text_display":" comparing the relative burden of different diseases, and examining the health benefits associated","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1880,520],[1880,569],[245,569]],"region":{"top_left_x":244,"top_left_y":519,"width":1636,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99189c23118c4c8c9404b2affbdfc8a9","type":"text","conversion_output":true,"text":"with a wide range of treatments. It should be noted that there is no defined MOS SF-36 score that","text_display":" with a wide range of treatments. It should be noted that there is no defined MOS SF-36 score that","confidence":0.998046875,"confidence_rate":0.9999808331754918},{"cnt":[[245,567],[1880,567],[1880,621],[245,621]],"region":{"top_left_x":244,"top_left_y":567,"width":1636,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e205b73f74a1487483f69852710d6d28","type":"text","conversion_output":true,"text":"represents a healthy, unimpaired condition. A subject with no disease symptoms would not","text_display":" represents a healthy, unimpaired condition. A subject with no disease symptoms would not","confidence":1,"confidence_rate":1},{"cnt":[[245,614],[1880,614],[1880,668],[245,668]],"region":{"top_left_x":244,"top_left_y":614,"width":1636,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd18364c75e64703b26c20e20fc9b409","type":"text","conversion_output":true,"text":"necessarily have subscale scores of 100 or corresponding physical, mental, and summary scores","text_display":" necessarily have subscale scores of 100 or corresponding physical, mental, and summary scores","confidence":0.99658203125,"confidence_rate":0.9999661013334881},{"cnt":[[245,662],[490,662],[490,711],[245,711]],"region":{"top_left_x":244,"top_left_y":661,"width":246,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bac380d6b0dc4a2dabfad7c7328c4360","type":"text","conversion_output":true,"text":"of 400 or 800 .","text_display":" of 400 or 800 .","confidence":0.89599609375,"confidence_rate":0.995785091394418},{"cnt":[[245,752],[1880,752],[1880,804],[245,804]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d99035e78144382b209c5c9b24c5d78","type":"text","conversion_output":true,"text":"According to the User's Manual for the MOS SF-36 v. 2.0 Health Survey and Kosinski et","text_display":"\n\nAccording to the User's Manual for the MOS SF-36 v. 2.0 Health Survey and Kosinski et","confidence":0.7632989883422852,"confidence_rate":0.9970033271748384},{"cnt":[[245,799],[1880,799],[1880,853],[245,853]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6b405862fd34e1095151cdd3114179d","type":"text","conversion_output":true,"text":"al. (35), \"minimal important differences\" in MOS SF-36 scores consist of changes of 2 to 4","text_display":" al. (35), \"minimal important differences\" in MOS SF-36 scores consist of changes of 2 to 4","confidence":1,"confidence_rate":1},{"cnt":[[243,849],[1008,849],[1008,900],[243,900]],"region":{"top_left_x":242,"top_left_y":848,"width":766,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9ca3f35f1d24bc0923e4559f2a228ba","type":"text","conversion_output":true,"text":"points, depending on the subscale concerned.","text_display":" points, depending on the subscale concerned.","confidence":1,"confidence_rate":1},{"cnt":[[240,1061],[241,932],[1886,935],[1886,1063]],"region":{"top_left_x":240,"top_left_y":932,"width":1647,"height":132},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0e7702c45ab4d1386af403162500ee9","type":"section_header","conversion_output":false,"children_ids":["48aebd4a12cd4ec2968adce0415764f1","49c299289639493fa2338656a6667075"],"text":"","text_display":""},{"cnt":[[245,941],[1880,941],[1880,995],[245,995]],"region":{"top_left_x":244,"top_left_y":941,"width":1636,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48aebd4a12cd4ec2968adce0415764f1","type":"text","conversion_output":true,"parent_id":"f0e7702c45ab4d1386af403162500ee9","text":"7.7.3 Measure of Intermittent and Constant Osteoarthritis Pain","text_display":"\n\n\\subsection*{7.7.3 Measure of Intermittent and Constant Osteoarthritis Pain","confidence":1,"confidence_rate":1},{"cnt":[[593,997],[900,997],[900,1055],[593,1055]],"region":{"top_left_x":592,"top_left_y":996,"width":309,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49c299289639493fa2338656a6667075","type":"text","conversion_output":true,"parent_id":"f0e7702c45ab4d1386af403162500ee9","text":"Questionnaire","text_display":" Questionnaire}","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[1880,1091],[1880,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1091,"width":1636,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4abcf789a0e84cec9c4ee8d8692fa832","type":"text","conversion_output":true,"text":"The ICOAP (36),(37),(38) is an 11-item questionnaire for assessment of pain in subjects with","text_display":"\n\nThe ICOAP (36),(37),(38) is an 11-item questionnaire for assessment of pain in subjects with","confidence":0.994631290435791,"confidence_rate":0.9999445049123337},{"cnt":[[245,1139],[1880,1139],[1880,1192],[245,1192]],"region":{"top_left_x":244,"top_left_y":1138,"width":1636,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86cbafb0b56e4468bd13d70e0f040c9a","type":"text","conversion_output":true,"text":"OA that considers both constant and intermittent experiences of pain. Questions address the","text_display":" OA that considers both constant and intermittent experiences of pain. Questions address the","confidence":0.99853515625,"confidence_rate":0.9999847301407262},{"cnt":[[245,1188],[1880,1188],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1188,"width":1636,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7017830d5d9f4047a20067a08c64a30e","type":"text","conversion_output":true,"text":"frequency and severity of pain and its impact on the subject's QOL (including sleep and","text_display":" frequency and severity of pain and its impact on the subject's QOL (including sleep and","confidence":1,"confidence_rate":1},{"cnt":[[245,1238],[578,1238],[578,1287],[245,1287]],"region":{"top_left_x":244,"top_left_y":1237,"width":334,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05e6f31a7a434072bccab019eec6d4f7","type":"text","conversion_output":true,"text":"emotional distress).","text_display":" emotional distress).","confidence":1,"confidence_rate":1},{"cnt":[[245,1326],[1878,1326],[1878,1377],[245,1377]],"region":{"top_left_x":244,"top_left_y":1325,"width":1634,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9217d7e5952242c4a1a6e60b2edcca67","type":"text","conversion_output":true,"text":"The ICOAP is designed to be responsive to change in pain over time and with treatment.","text_display":"\n\nThe ICOAP is designed to be responsive to change in pain over time and with treatment.","confidence":1,"confidence_rate":1},{"cnt":[[245,1371],[1880,1371],[1880,1424],[245,1424]],"region":{"top_left_x":244,"top_left_y":1370,"width":1636,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fd9c24a87e249139d09bc23b6c01438","type":"text","conversion_output":true,"text":"Subjects are asked to respond to the questionnaire considering their symptoms over the past","text_display":" Subjects are asked to respond to the questionnaire considering their symptoms over the past","confidence":1,"confidence_rate":1},{"cnt":[[245,1422],[1882,1422],[1882,1472],[245,1472]],"region":{"top_left_x":244,"top_left_y":1422,"width":1639,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9ca8d936dbd4aea913e86f1fc3c455b","type":"text","conversion_output":true,"text":"week, taking into consideration any pain medication that they may be using (i.e., to report their","text_display":" week, taking into consideration any pain medication that they may be using (i.e., to report their","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,1470],[1059,1470],[1059,1521],[245,1521]],"region":{"top_left_x":244,"top_left_y":1469,"width":816,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa6d91632dc34766b8459c72b5046285","type":"text","conversion_output":true,"text":"experience of pain while taking the medication).","text_display":" experience of pain while taking the medication).","confidence":1,"confidence_rate":1},{"cnt":[[245,1560],[1880,1560],[1880,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1559,"width":1636,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5282af9de52646e1b28179c9d74530f3","type":"text","conversion_output":true,"text":"The ICOAP yields a total pain score that can range from 0 to 44 points, a constant pain subscore","text_display":"\n\nThe ICOAP yields a total pain score that can range from 0 to 44 points, a constant pain subscore","confidence":1,"confidence_rate":1},{"cnt":[[245,1607],[1880,1607],[1880,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1607,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84928f63fc8341f3a59a742894b97b47","type":"text","conversion_output":true,"text":"that can range from 0 to 20 points, and an intermittent pain subscore that can range from 0 to 24","text_display":" that can range from 0 to 20 points, and an intermittent pain subscore that can range from 0 to 24","confidence":0.99560546875,"confidence_rate":0.9999599624780234},{"cnt":[[245,1654],[1450,1654],[1450,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1654,"width":1207,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4aa8207d62a14a5984dfdc7eb09fbac4","type":"text","conversion_output":true,"text":"points; higher scores indicate more severe, frequent, or distressing pain.","text_display":" points; higher scores indicate more severe, frequent, or distressing pain.","confidence":1,"confidence_rate":1},{"cnt":[[241,1740],[1381,1740],[1381,1811],[241,1811]],"region":{"top_left_x":240,"top_left_y":1740,"width":1142,"height":72},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f8a36aecbaa48a28c78af1d08a47b19","type":"section_header","conversion_output":false,"children_ids":["4c94121172364a2f8a4575efa87fab34"],"text":"","text_display":""},{"cnt":[[245,1747],[1377,1747],[1377,1803],[245,1803]],"region":{"top_left_x":244,"top_left_y":1746,"width":1134,"height":57},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c94121172364a2f8a4575efa87fab34","type":"text","conversion_output":true,"parent_id":"2f8a36aecbaa48a28c78af1d08a47b19","text":"7.7.4 Patient Global Impression of Change","text_display":"\n\n\\subsection*{7.7.4 Patient Global Impression of Change}","confidence":0.99951171875,"confidence_rate":0.9999893826542317},{"cnt":[[245,1841],[1880,1841],[1880,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1841,"width":1636,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac64aa6ac87e4277985ef3479c932978","type":"text","conversion_output":true,"text":"Global impression scales (39) are recommended for use in chronic pain clinical trials as a core","text_display":"\n\nGlobal impression scales (39) are recommended for use in chronic pain clinical trials as a core","confidence":1,"confidence_rate":1},{"cnt":[[245,1891],[1880,1891],[1880,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1890,"width":1636,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ea4ff9f1f7a4f54981075e5ec77f313","type":"text","conversion_output":true,"text":"outcome measure of global improvement with treatment relative to baseline symptoms (40). It","text_display":" outcome measure of global improvement with treatment relative to baseline symptoms (40). It","confidence":0.99853515625,"confidence_rate":0.9999847301407262},{"cnt":[[245,1938],[1880,1938],[1880,1989],[245,1989]],"region":{"top_left_x":244,"top_left_y":1937,"width":1636,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6345e2399b347de989dede76a3b57dd","type":"text","conversion_output":true,"text":"provides a responsive and readily interpretable measure of participant's assessments of the","text_display":" provides a responsive and readily interpretable measure of participant's assessments of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1985],[1760,1985],[1760,2039],[245,2039]],"region":{"top_left_x":244,"top_left_y":1985,"width":1516,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"647bd4978cb54e61ac517ae67670ad16","type":"text","conversion_output":true,"text":"clinical importance of their improvement or worsening over the course of the clinical trial.","text_display":" clinical importance of their improvement or worsening over the course of the clinical trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1880,2075],[1880,2125],[245,2125]],"region":{"top_left_x":244,"top_left_y":2075,"width":1636,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c27f030c7a9243e188b59f4fd3499a45","type":"text","conversion_output":true,"text":"The PGIC used in this trial is based on the IMMPACT recommendations (40) and will assess the","text_display":"\n\nThe PGIC used in this trial is based on the IMMPACT recommendations (40) and will assess the","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,2123],[1613,2123],[1613,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2122,"width":1370,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68ebebfdea6f4d93b248dc516af257e4","type":"text","conversion_output":true,"text":"subject's global improvement since starting study treatment using a 7-point scale:","text_display":" subject's global improvement since starting study treatment using a 7-point scale:","confidence":0.974609375,"confidence_rate":0.9997044284107192},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2384240798414fb4a20c915d3950c582","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2548],[389,2545],[390,2587],[245,2589]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":46},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"752af936717349f68b64b2ec0c8f0a42","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.9990234375,"confidence_rate":0.9999348661447799},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca55e3666ef2447abc3c6963a977150c","type":"page_info","conversion_output":false,"text":"82/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2610],[1796,2610]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":111},"line":41,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"d29bec4003b24903bf680180ddd0628e","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.9990234375,"confidence_rate":0.9998371733163992}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-083","page":83,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"740e7d36cc1d4e3dbbcea48b966002b0","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fff94335940345369cbc950278f9610a","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"215545210c73419f8c9121451ce83c7f","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[365,279],[1880,279],[1880,333],[365,333]],"region":{"top_left_x":365,"top_left_y":279,"width":1515,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f40cb7b4905c46578b922848636d4ee9","type":"text","conversion_output":true,"text":"\"Since getting the first injection of study treatment in your knee how would you describe","text_display":"\n\"Since getting the first injection of study treatment in your knee how would you describe","confidence":1,"confidence_rate":1},{"cnt":[[365,329],[1158,329],[1158,380],[365,380]],"region":{"top_left_x":365,"top_left_y":328,"width":794,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e16b48fc6384a719df15ceadd2ae604","type":"text","conversion_output":true,"text":"the change in overall symptoms for this knee:\"","text_display":" the change in overall symptoms for this knee:\"","confidence":1,"confidence_rate":1},{"cnt":[[490,382],[913,382],[913,434],[490,434]],"region":{"top_left_x":489,"top_left_y":382,"width":425,"height":52},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"773cff277d054e87b503a2be7f9066e4","type":"text","conversion_output":true,"text":"\\(1=\\) very much improved","text_display":"\n\\(1=\\) very much improved","confidence":0.9917135238647461,"confidence_rate":0.9996672153918551},{"cnt":[[490,438],[827,438],[827,488],[490,488]],"region":{"top_left_x":489,"top_left_y":438,"width":339,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4459ccdffcc54c1faac5d1f386318f0f","type":"text","conversion_output":true,"text":"\\(2=\\) much improved","text_display":"\n\\(2=\\) much improved","confidence":0.8993068503914401,"confidence_rate":0.9947075059278597},{"cnt":[[490,494],[907,494],[907,544],[490,544]],"region":{"top_left_x":489,"top_left_y":494,"width":418,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dabb600eddb14630b4403fcc394d363a","type":"text","conversion_output":true,"text":"3 = minimally improved","text_display":"\n3 = minimally improved","confidence":0.99169921875,"confidence_rate":0.9996794581314866},{"cnt":[[490,546],[735,546],[735,599],[490,599]],"region":{"top_left_x":489,"top_left_y":545,"width":246,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8770c559dd824ab98291fc6a668dca53","type":"text","conversion_output":true,"text":"4 = no change","text_display":"\n4 = no change","confidence":0.8837890625,"confidence_rate":0.9927594656596435},{"cnt":[[490,604],[844,604],[844,655],[490,655]],"region":{"top_left_x":489,"top_left_y":603,"width":356,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fbff53c7e694c14b09632d0652e5814","type":"text","conversion_output":true,"text":"\\(5=\\) minimally worse","text_display":"\n\\(5=\\) minimally worse","confidence":0.9843823909759521,"confidence_rate":0.9992847627812912},{"cnt":[[490,660],[767,660],[767,703],[490,703]],"region":{"top_left_x":489,"top_left_y":659,"width":278,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5660dff100a94e1abd900adb3c0edc2f","type":"text","conversion_output":true,"text":"\\(6=\\) much worse","text_display":"\n\\(6=\\) much worse","confidence":0.95202059391886,"confidence_rate":0.9971119072837844},{"cnt":[[490,713],[853,713],[853,763],[490,763]],"region":{"top_left_x":489,"top_left_y":713,"width":364,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e9a778821f34150a6c00749b5532942","type":"text","conversion_output":true,"text":"\\(7=\\) very much worse","text_display":"\n\\(7=\\) very much worse","confidence":0.99951171875,"confidence_rate":0.9999778002237774},{"cnt":[[241,799],[1525,799],[1525,866],[241,866]],"region":{"top_left_x":240,"top_left_y":799,"width":1286,"height":67},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57c606620ef84d36af3ee6fee5f746bb","type":"section_header","conversion_output":false,"children_ids":["6b781dc597d64bc3820bff9330d78d42"],"text":"","text_display":""},{"cnt":[[245,808],[1519,808],[1519,862],[245,862]],"region":{"top_left_x":244,"top_left_y":807,"width":1275,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b781dc597d64bc3820bff9330d78d42","type":"text","conversion_output":true,"parent_id":"57c606620ef84d36af3ee6fee5f746bb","text":"7.7.5 11-Point Numerical Rating Scale Pain Score","text_display":"\n\n\\subsection*{7.7.5 11-Point Numerical Rating Scale Pain Score}","confidence":1,"confidence_rate":1},{"cnt":[[245,898],[1880,898],[1880,952],[245,952]],"region":{"top_left_x":244,"top_left_y":898,"width":1636,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7f963cf7c974d5192c239c1fed884fd","type":"text","conversion_output":true,"text":"The subject will indicate the worst pain in past 24 hours in the target and contralateral knee using","text_display":"\n\nThe subject will indicate the worst pain in past 24 hours in the target and contralateral knee using","confidence":1,"confidence_rate":1},{"cnt":[[245,950],[1880,950],[1880,999],[245,999]],"region":{"top_left_x":244,"top_left_y":949,"width":1636,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac419e1570ca48378398d879b741eebc","type":"text","conversion_output":true,"text":"an 11-point NRS. The NRS for pain is a patient-reported unidimensional pain scale","text_display":" an 11-point NRS. The NRS for pain is a patient-reported unidimensional pain scale","confidence":0.97900390625,"confidence_rate":0.9997532903631924},{"cnt":[[245,997],[1880,997],[1880,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":996,"width":1636,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e76f6be7670845768c963a2847c10ff2","type":"text","conversion_output":true,"text":"recommended for assessing pain intensity (41) which is frequently used instrument in pain trials,","text_display":" recommended for assessing pain intensity (41) which is frequently used instrument in pain trials,","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[900,1044],[900,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":657,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ff1903ee6774c8dad8fbda23605dbb4","type":"text","conversion_output":true,"text":"and also in subjects with osteoarthritis.","text_display":" and also in subjects with osteoarthritis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[1880,1134],[1880,1184],[245,1184]],"region":{"top_left_x":244,"top_left_y":1134,"width":1636,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90b7c1ecea164c539cb55211992c9463","type":"text","conversion_output":true,"text":"The NRS is scaled from 0 (no pain) to 10 (worst possible pain). It has good validity, reliability,","text_display":"\n\nThe NRS is scaled from 0 (no pain) to 10 (worst possible pain). It has good validity, reliability,","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[245,1182],[1880,1182],[1880,1231],[245,1231]],"region":{"top_left_x":244,"top_left_y":1181,"width":1636,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3f52844bc114caa891d130ea2cb9524","type":"text","conversion_output":true,"text":"and sensitivity, being similar in sensitivity to a \\(100- mm\\) VAS when comparing postoperative","text_display":" and sensitivity, being similar in sensitivity to a \\(100- mm\\) VAS when comparing postoperative","confidence":0.951195478439331,"confidence_rate":0.9995047198486582},{"cnt":[[245,1229],[569,1229],[569,1280],[245,1280]],"region":{"top_left_x":244,"top_left_y":1228,"width":326,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d35db622b1147698ee756b69d6e96b1","type":"text","conversion_output":true,"text":"pain intensity (42).","text_display":" pain intensity (42).","confidence":1,"confidence_rate":1},{"cnt":[[245,1319],[1880,1319],[1880,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1319,"width":1636,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6ca02e8b4a44a3da4b8b7eaa8834d45","type":"text","conversion_output":true,"text":"In this protocol, the NRS will be used as a supplementary pain scale to the WOMAC. The NRS","text_display":"\n\nIn this protocol, the NRS will be used as a supplementary pain scale to the WOMAC. The NRS","confidence":0.95849609375,"confidence_rate":0.9995538912005244},{"cnt":[[245,1366],[1880,1366],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1366,"width":1636,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7efeb09efc9c446fa145c29fabd6e039","type":"text","conversion_output":true,"text":"has a 24 -hour recall period, which may be preferable for detecting recent changes in health status","text_display":" has a 24 -hour recall period, which may be preferable for detecting recent changes in health status","confidence":0.5732421875,"confidence_rate":0.9948130597539983},{"cnt":[[245,1414],[1880,1414],[1880,1465],[245,1465]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b898403182154129b509aeda11294ab7","type":"text","conversion_output":true,"text":"compared to PRO questionnaires with longer recall periods (43). Also, the NRS involves a single","text_display":" compared to PRO questionnaires with longer recall periods (43). Also, the NRS involves a single","confidence":0.994140625,"confidence_rate":0.9999412356418027},{"cnt":[[245,1463],[1884,1463],[1884,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1463,"width":1641,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"222d0d38d7b74e7495b4eea64424b5df","type":"text","conversion_output":true,"text":"overall question whereas the WOMAC uses a group questions to characterize different aspects of","text_display":" overall question whereas the WOMAC uses a group questions to characterize different aspects of","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1512],[423,1512],[423,1562],[245,1562]],"region":{"top_left_x":244,"top_left_y":1512,"width":180,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62022a214c5f4f8bb57ec47167f6f5ea","type":"text","conversion_output":true,"text":"knee pain.","text_display":" knee pain.","confidence":1,"confidence_rate":1},{"cnt":[[243,1601],[1027,1601],[1027,1656],[243,1656]],"region":{"top_left_x":242,"top_left_y":1600,"width":785,"height":57},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e444accd13a54b078f81b24053902101","type":"section_header","conversion_output":false,"children_ids":["c6dea90bab574461b89eb867dbb75db6"],"text":"","text_display":""},{"cnt":[[247,1603],[1023,1603],[1023,1652],[247,1652]],"region":{"top_left_x":247,"top_left_y":1602,"width":776,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6dea90bab574461b89eb867dbb75db6","type":"text","conversion_output":true,"parent_id":"e444accd13a54b078f81b24053902101","text":"7.7.6 Pain in Other Joints","text_display":"\n\n\\subsection*{7.7.6 Pain in Other Joints}","confidence":1,"confidence_rate":1},{"cnt":[[245,1697],[1880,1697],[1880,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1697,"width":1636,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43f87eb64fc34fd6ac7d544f428fccbe","type":"text","conversion_output":true,"text":"Data on the presence of pain in 'other' joints (that is, joints other than the knee) will be obtained","text_display":"\n\nData on the presence of pain in 'other' joints (that is, joints other than the knee) will be obtained","confidence":0.9965860823871253,"confidence_rate":0.9999677386494035},{"cnt":[[245,1747],[1880,1747],[1880,1796],[245,1796]],"region":{"top_left_x":244,"top_left_y":1746,"width":1636,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8baa25615d9c4ef1931c48ec7f17ace2","type":"text","conversion_output":true,"text":"because, like pain in the contralateral knee, pain in other joints could potentially become a","text_display":" because, like pain in the contralateral knee, pain in other joints could potentially become a","confidence":0.9990236759185791,"confidence_rate":0.9999900326925697},{"cnt":[[245,1794],[1880,1794],[1880,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1793,"width":1636,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6fbc36cd2de4d29acc3ed01c25b46f8","type":"text","conversion_output":true,"text":"confounding variable when assessing self-reported activities of daily living (WOMAC ADL),","text_display":" confounding variable when assessing self-reported activities of daily living (WOMAC ADL),","confidence":1,"confidence_rate":1},{"cnt":[[245,1843],[1880,1843],[1880,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1843,"width":1636,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea015a16564844b7974e6bb65f3ba88c","type":"text","conversion_output":true,"text":"physical functioning during the 20 -meter walk test, and overall health-related quality of life","text_display":" physical functioning during the 20 -meter walk test, and overall health-related quality of life","confidence":0.98046875,"confidence_rate":0.9998085182830444},{"cnt":[[245,1891],[1880,1891],[1880,1940],[245,1940]],"region":{"top_left_x":244,"top_left_y":1890,"width":1636,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef6e79531bb04b8d92cebd0844b5ab3f","type":"text","conversion_output":true,"text":"(MOS SF-36). Pain in other joints may also serve as indicator of overall OA progression. As has","text_display":" (MOS SF-36). Pain in other joints may also serve as indicator of overall OA progression. As has","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1880,1938],[1880,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1937,"width":1636,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b6687a7034742c6ad1b4f897df02ea2","type":"text","conversion_output":true,"text":"been recommended for use in OA studies (44), a scale model of the human body (homunculus)","text_display":" been recommended for use in OA studies (44), a scale model of the human body (homunculus)","confidence":1,"confidence_rate":1},{"cnt":[[245,1985],[1880,1985],[1880,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1985,"width":1636,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"670a8864164b4480a9f265d1c01cd1f1","type":"text","conversion_output":true,"text":"will be used (see Appendix F). During subject interview, the homunculus, with circles in six","text_display":" will be used (see Appendix F). During subject interview, the homunculus, with circles in six","confidence":1,"confidence_rate":1},{"cnt":[[245,2032],[1880,2032],[1880,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2032,"width":1636,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47d95a15d5c64714afc4c7617ff7b0b7","type":"text","conversion_output":true,"text":"bilateral joints (shoulder, elbow, wrist, hand/finger, ankle, foot) and neck, for a total of 13 joints,","text_display":" bilateral joints (shoulder, elbow, wrist, hand/finger, ankle, foot) and neck, for a total of 13 joints,","confidence":1,"confidence_rate":1},{"cnt":[[245,2082],[1102,2082],[1102,2133],[245,2133]],"region":{"top_left_x":244,"top_left_y":2081,"width":859,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d77eff8e7fab41a295c4bdea8842f07e","type":"text","conversion_output":true,"text":"will be shown to subjects to indicate painful joints.","text_display":" will be shown to subjects to indicate painful joints.","confidence":1,"confidence_rate":1},{"cnt":[[243,2170],[793,2170],[793,2224],[243,2224]],"region":{"top_left_x":242,"top_left_y":2169,"width":551,"height":55},"line":38,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"45d5ec09f6d841ce8d8ab820db1ee601","type":"section_header","conversion_output":false,"children_ids":["79ecb4cea6114b3d85d80b556f760b8c"],"text":"","text_display":""},{"cnt":[[245,2174],[788,2174],[788,2219],[245,2219]],"region":{"top_left_x":244,"top_left_y":2174,"width":545,"height":46},"line":39,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"79ecb4cea6114b3d85d80b556f760b8c","type":"text","conversion_output":true,"parent_id":"45d5ec09f6d841ce8d8ab820db1ee601","text":"8 Statistics","text_display":"\n\n\\section*{8 Statistics}","confidence":1,"confidence_rate":1},{"cnt":[[243,2269],[857,2269],[857,2331],[243,2331]],"region":{"top_left_x":242,"top_left_y":2268,"width":616,"height":64},"line":40,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"cc243734d3cb4a38ab60e002fe88f029","type":"section_header","conversion_output":false,"children_ids":["478c375a43d6459e88147d54a25aad54"],"text":"","text_display":""},{"cnt":[[249,2273],[853,2273],[853,2327],[249,2327]],"region":{"top_left_x":249,"top_left_y":2273,"width":604,"height":54},"line":41,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"478c375a43d6459e88147d54a25aad54","type":"text","conversion_output":true,"parent_id":"cc243734d3cb4a38ab60e002fe88f029","text":"8.1 Sample Size","text_display":"\n\n\\subsection*{8.1 Sample Size}","confidence":0.94873046875,"confidence_rate":0.9973719325924602},{"cnt":[[245,2368],[1880,2368],[1880,2417],[245,2417]],"region":{"top_left_x":244,"top_left_y":2367,"width":1636,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6fd0f90f0504d46bff8d918dc27bafc","type":"text","conversion_output":true,"text":"The sample size was determined from expected changes in the primary endpoint: the change","text_display":"\n\nThe sample size was determined from expected changes in the primary endpoint: the change","confidence":1,"confidence_rate":1},{"cnt":[[245,2415],[1871,2415],[1871,2464],[245,2464]],"region":{"top_left_x":244,"top_left_y":2414,"width":1628,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4956837b47a47c5a3e1ff3d330ca221","type":"text","conversion_output":true,"text":"from baseline in cartilage thickness in the total femorotibial joint as evaluated by MRI at 2 years.","text_display":" from baseline in cartilage thickness in the total femorotibial joint as evaluated by MRI at 2 years.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cf7006171fac46919b627401d0b05b32","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d91edbc676c14b219ed97f786b048847","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968649},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e875aeb11eb9425fbbfd343e1aaa4484","type":"page_info","conversion_output":false,"text":"83/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1798,2509],[1904,2509],[1904,2608],[1798,2608]],"region":{"top_left_x":1798,"top_left_y":2509,"width":106,"height":100},"line":47,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"63ab87e179f245569097a4396ba7252d","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999186032298787}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-084","page":84,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"539dd670c2ce4a5bbe2d7709593ff8f3","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1319,125],[1319,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":678,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44e4a839487e4f19802f6e3a62871005","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e10e3a13de74762b40a0b7a0f495033","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5844189ce09642a4bd4f154728881170","type":"text","conversion_output":true,"text":"This trial is set up to detect a potential dose relationship, based on the total dose of sprifermin","text_display":"\n\nThis trial is set up to detect a potential dose relationship, based on the total dose of sprifermin","confidence":1,"confidence_rate":1},{"cnt":[[243,329],[1882,329],[1882,380],[243,380]],"region":{"top_left_x":242,"top_left_y":328,"width":1641,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2bd5c84a3604e97bcfe4cc572926918","type":"text","conversion_output":true,"text":"received over the 2 years, in limiting the reduction of or increasing the cartilage thickness in the","text_display":" received over the 2 years, in limiting the reduction of or increasing the cartilage thickness in the","confidence":0.998046875,"confidence_rate":0.9999818979894378},{"cnt":[[245,378],[821,378],[821,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":577,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2254c39d46ea435fb89d62cfb8f654b4","type":"text","conversion_output":true,"text":"total femorotibial joint, assuming:","text_display":" total femorotibial joint, assuming:","confidence":1,"confidence_rate":1},{"cnt":[[245,447],[1021,447],[1021,501],[245,501]],"region":{"top_left_x":244,"top_left_y":446,"width":777,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01cddab64bc242f0b207a2872b38ff2a","type":"text","conversion_output":true,"text":"- A mean change from baseline at 2 years of","text_display":"\n- A mean change from baseline at 2 years of","confidence":1,"confidence_rate":1},{"cnt":[[294,520],[1296,520],[1296,574],[294,574]],"region":{"top_left_x":294,"top_left_y":519,"width":1002,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"827f99efa7004dfeb4a8cd7350d15e79","type":"text","conversion_output":true,"text":"- -0.03 mm in the placebo group (i.e., 0 mcg over 2 years)","text_display":"\n- -0.03 mm in the placebo group (i.e., 0 mcg over 2 years)","confidence":0.9621054281014949,"confidence_rate":0.9994918233536688},{"cnt":[[294,591],[1714,591],[1714,647],[294,647]],"region":{"top_left_x":294,"top_left_y":590,"width":1421,"height":57},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fe76ad1b6f547a08a1fb61e544a70a5","type":"text","conversion_output":true,"text":"- -0.01 mm in the sprifermin 30 mcg once a year group (i.e., 180 mcg over 2 years)","text_display":"\n- -0.01 mm in the sprifermin 30 mcg once a year group (i.e., 180 mcg over 2 years)","confidence":0.9805199657682806,"confidence_rate":0.9998126625907079},{"cnt":[[294,662],[1738,662],[1738,718],[294,718]],"region":{"top_left_x":294,"top_left_y":661,"width":1445,"height":57},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4e3ec1d7f674cdeba5e7708df3acd87","type":"text","conversion_output":true,"text":"- +0.01 mm in the sprifermin 30 mcg twice a year group (i.e., 360 mcg over 2 years)","text_display":"\n- +0.01 mm in the sprifermin 30 mcg twice a year group (i.e., 360 mcg over 2 years)","confidence":0.8689050674438477,"confidence_rate":0.9986752047026491},{"cnt":[[294,735],[1747,735],[1747,788],[294,788]],"region":{"top_left_x":294,"top_left_y":734,"width":1453,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ded3a838656d493390bbbaa91c8db2ba","type":"text","conversion_output":true,"text":"- +0.01 mm in the sprifermin 100 mcg once a year group (i.e., 600 mcg over 2 years)","text_display":"\n- +0.01 mm in the sprifermin 100 mcg once a year group (i.e., 600 mcg over 2 years)","confidence":0.9975602623308077,"confidence_rate":0.9999769557496859},{"cnt":[[294,808],[1777,808],[1777,862],[294,862]],"region":{"top_left_x":294,"top_left_y":807,"width":1483,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16845d6f4d874c709e311b96e86495b6","type":"text","conversion_output":true,"text":"- +0.03 mm in the sprifermin 100 mcg twice a year group (i.e., 1200 mcg over 2 years)","text_display":"\n- +0.03 mm in the sprifermin 100 mcg twice a year group (i.e., 1200 mcg over 2 years)","confidence":0.9839344024658203,"confidence_rate":0.9998500478336465},{"cnt":[[245,879],[1104,879],[1104,930],[245,930]],"region":{"top_left_x":244,"top_left_y":878,"width":861,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0de7bb51f4bc4b9c826b10445fad5cf4","type":"text","conversion_output":true,"text":"- A common SD (standard deviation) of 0.10 mm","text_display":"\n- A common SD (standard deviation) of 0.10 mm","confidence":1,"confidence_rate":1},{"cnt":[[245,950],[1515,950],[1515,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":949,"width":1271,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c50f03fe817d4bbda0209f5dc575f56c","type":"text","conversion_output":true,"text":"- A type-one error, \\(\\alpha\\), of the primary efficacy analysis set at \\(5 \\%\\) two-sided","text_display":"\n- A type-one error, \\(\\alpha\\), of the primary efficacy analysis set at \\(5 \\%\\) two-sided","confidence":0.99462890625,"confidence_rate":0.999938098813284},{"cnt":[[245,1023],[642,1023],[642,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1022,"width":399,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c47dd5ea9a540028f9181a1d894e839","type":"text","conversion_output":true,"text":"- Normal distribution.","text_display":"\n- Normal distribution.","confidence":0.99951171875,"confidence_rate":0.9999819112562659},{"cnt":[[245,1111],[1880,1111],[1880,1162],[245,1162]],"region":{"top_left_x":244,"top_left_y":1110,"width":1636,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fe2584b9adc4bf983dce5c36c8a74c7","type":"text","conversion_output":true,"text":"The above assumptions were based on available MRI data from the OAI (http://oai.epi-","text_display":"\n\nThe above assumptions were based on available MRI data from the OAI (http://oai.epi","confidence":0.99609375,"confidence_rate":0.9999560245700808},{"cnt":[[245,1160],[1381,1160],[1381,1212],[245,1212]],"region":{"top_left_x":244,"top_left_y":1160,"width":1138,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9144b65a0cfd4d1da5b4f9a2a0e44a2a","type":"text","conversion_output":true,"text":"ucsf.org/datarelease/) and from the POC trial (28980; see Figure 3).","text_display":"ucsf.org/datarelease/) and from the POC trial (28980; see Figure 3).","confidence":1,"confidence_rate":1},{"cnt":[[245,1250],[1880,1250],[1880,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1250,"width":1636,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94de2a32edc64ef4bfaf86130fd502b5","type":"text","conversion_output":true,"text":"A minor deviation from linearity has been introduced in these hypotheses based on the","text_display":"\n\nA minor deviation from linearity has been introduced in these hypotheses based on the","confidence":1,"confidence_rate":1},{"cnt":[[245,1298],[1882,1298],[1882,1349],[245,1349]],"region":{"top_left_x":244,"top_left_y":1297,"width":1639,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13759305072445349c9090fb8a8792c2","type":"text","conversion_output":true,"text":"expectation of similar changes for the sprifermin 30 mcg twice a year and sprifermin 100 mcg","text_display":" expectation of similar changes for the sprifermin 30 mcg twice a year and sprifermin 100 mcg","confidence":0.998046875,"confidence_rate":0.9999810192594005},{"cnt":[[245,1345],[1884,1345],[1884,1396],[245,1396]],"region":{"top_left_x":244,"top_left_y":1344,"width":1641,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0978b855963041beada57805091dd6bb","type":"text","conversion_output":true,"text":"once a year groups. Indeed, according to the current knowledge of the biological mechanism of","text_display":" once a year groups. Indeed, according to the current knowledge of the biological mechanism of","confidence":1,"confidence_rate":1},{"cnt":[[245,1394],[1880,1394],[1880,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1394,"width":1636,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71afa21a07a248fab667b46a69648f65","type":"text","conversion_output":true,"text":"action of sprifermin, the treatment effect of the highest dose ( 100 mcg ) given once a year could","text_display":" action of sprifermin, the treatment effect of the highest dose ( 100 mcg ) given once a year could","confidence":0.8889924229283692,"confidence_rate":0.998911088048645},{"cnt":[[245,1439],[1880,1439],[1880,1493],[245,1493]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad2e6c6a179f40a18bba3c90bd254685","type":"text","conversion_output":true,"text":"be similar to that of a lower dose ( 30 mcg ) given twice a year. Moreover, the variability of the","text_display":" be similar to that of a lower dose ( 30 mcg ) given twice a year. Moreover, the variability of the","confidence":0.5804078357570006,"confidence_rate":0.994975404083608},{"cnt":[[245,1489],[1629,1489],[1629,1540],[245,1540]],"region":{"top_left_x":244,"top_left_y":1488,"width":1385,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d4867b424af48469ddbcba65a70bc80","type":"text","conversion_output":true,"text":"measure is large, and therefore a deviation from perfect linearity may be expected.","text_display":" measure is large, and therefore a deviation from perfect linearity may be expected.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6126ff3d384845a7a38f796af87e3e34","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5eac981486c54441b9f62ca210769bea","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6df292735e5a4844984c50ec856de2b4","type":"page_info","conversion_output":false,"text":"84/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2608],[1796,2608]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":109},"line":27,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"100e2cde512a46fa8f1996c525ec7f65","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999186032298787}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-085","page":85,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7defe44ccddc4dce8fe706dbf51ef41d","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32c1470d443640a89c235ea9dd19e233","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fe46daaf8034b5f82d4cc08d4937cd4","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1884,279],[1884,359],[245,359]],"region":{"top_left_x":244,"top_left_y":279,"width":1641,"height":80},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86648372208e4293a3b19229bae6f618","type":"figure_label","conversion_output":false,"children_ids":["d3dc9ce0535c4e00a35124f349b49aed"],"text":"","text_display":""},{"cnt":[[593,331],[947,331],[947,380],[593,380]],"region":{"top_left_x":592,"top_left_y":330,"width":356,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3dc9ce0535c4e00a35124f349b49aed","type":"text","conversion_output":false,"parent_id":"86648372208e4293a3b19229bae6f618","text":"2 Years \\(( SD = 0 . 1 0 )\\)","text_display":"","confidence":0.328380370734864,"confidence_rate":0.9580741502520911},{"cnt":[[258,423],[1826,423],[1826,1390],[258,1390]],"region":{"top_left_x":257,"top_left_y":423,"width":1570,"height":968},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"961aab47cb3543f890bd574a02b3ca4c","type":"chart","conversion_output":true,"selected_labels":["86648372208e4293a3b19229bae6f618"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{2 Years \\(( SD = 0 . 1 0 )\\)}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-085.jpg?height=968&width=1570&top_left_y=423&top_left_x=257}\n\\end{figure}","subtype":"column"},{"cnt":[[262,1396],[1175,1396],[1175,1437],[262,1437]],"region":{"top_left_x":262,"top_left_y":1396,"width":914,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"303e63b2f3ad4882a12559e43c09b48c","type":"text","conversion_output":true,"text":"OA: osteoarthritis; POC: proof of concept; SD: standard deviation","text_display":"\n\nOA: osteoarthritis; POC: proof of concept; SD: standard deviation","confidence":0.9790418011834845,"confidence_rate":0.9996974609238207},{"cnt":[[245,1495],[685,1495],[685,1540],[245,1540]],"region":{"top_left_x":244,"top_left_y":1495,"width":442,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b728ea3f2bd643e6b41f0d2ca9e3f865","type":"text","conversion_output":true,"text":"Calculations showed that:","text_display":"\n\nCalculations showed that:","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1884,1568],[1884,1620],[245,1620]],"region":{"top_left_x":244,"top_left_y":1568,"width":1641,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38e9a0c2ed5a4da2b7daa76942c4cc26","type":"text","conversion_output":true,"text":"- 55 evaluable subjects in each group (total 275 subjects) will ensure a power of \\(90 \\%\\) for","text_display":"\n- 55 evaluable subjects in each group (total 275 subjects) will ensure a power of \\(90 \\%\\) for","confidence":1,"confidence_rate":1},{"cnt":[[292,1616],[1296,1616],[1296,1669],[292,1669]],"region":{"top_left_x":292,"top_left_y":1615,"width":1004,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"503bb273053b4d1088142ae628f9da1e","type":"text","conversion_output":true,"text":"detecting a linear dose relationship using a linear trend test,","text_display":" detecting a linear dose relationship using a linear trend test,","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1884,1689],[1884,1738],[245,1738]],"region":{"top_left_x":244,"top_left_y":1688,"width":1641,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4d5bff6332a49e4b50fefaddda14634","type":"text","conversion_output":true,"text":"- 76 evaluable subjects in each group (total 380 subjects) will ensure a power of \\(90 \\%\\) for","text_display":"\n- 76 evaluable subjects in each group (total 380 subjects) will ensure a power of \\(90 \\%\\) for","confidence":1,"confidence_rate":1},{"cnt":[[292,1736],[1884,1736],[1884,1785],[292,1785]],"region":{"top_left_x":292,"top_left_y":1735,"width":1593,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16383769591d4bffb3f5c33c55cfd08b","type":"text","conversion_output":true,"text":"detecting an overall treatment effect (meaning that at least one group differs from the other","text_display":" detecting an overall treatment effect (meaning that at least one group differs from the other","confidence":1,"confidence_rate":1},{"cnt":[[292,1783],[569,1783],[569,1835],[292,1835]],"region":{"top_left_x":292,"top_left_y":1783,"width":278,"height":52},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"beeb4153f2bc41c2bfdd65ae9d736ca1","type":"text","conversion_output":true,"text":"groups) as well.","text_display":" groups) as well.","confidence":1,"confidence_rate":1},{"cnt":[[245,1873],[1882,1873],[1882,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1873,"width":1639,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c87e027a71943399f7f7448dfab272e","type":"text","conversion_output":true,"text":"Based on recent literature and other trial experience ( 45,46 ), the subject discontinuation rate is","text_display":"\n\nBased on recent literature and other trial experience ( 45,46 ), the subject discontinuation rate is","confidence":0.9153705167157077,"confidence_rate":0.9991815725078681},{"cnt":[[245,1921],[1882,1921],[1882,1972],[245,1972]],"region":{"top_left_x":244,"top_left_y":1920,"width":1639,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"782bad3e8c4e40e58a31d04a9dbfb99c","type":"text","conversion_output":true,"text":"estimated to be close to \\(30 \\%\\) at two years. Assuming a \\(30 \\%\\) drop-out rate, a total of 545 subjects","text_display":" estimated to be close to \\(30 \\%\\) at two years. Assuming a \\(30 \\%\\) drop-out rate, a total of 545 subjects","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[245,1968],[1794,1968],[1794,2020],[245,2020]],"region":{"top_left_x":244,"top_left_y":1967,"width":1550,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f077680885f843c8aa2b11577b17336f","type":"text","conversion_output":true,"text":"should be randomized ( 109 subjects per group) in order to detect an overall treatment effect.","text_display":" should be randomized ( 109 subjects per group) in order to detect an overall treatment effect.","confidence":0.9761075866408646,"confidence_rate":0.9997629450977372},{"cnt":[[245,2058],[1882,2058],[1882,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":1639,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91cd4ea576cb4e7e9412918c32fa1dc8","type":"text","conversion_output":true,"text":"In order to be able to demonstrate that structure improvement translates into symptomatic","text_display":"\n\nIn order to be able to demonstrate that structure improvement translates into symptomatic","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,2105],[1884,2105],[1884,2157],[245,2157]],"region":{"top_left_x":244,"top_left_y":2105,"width":1641,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"975589bbe1694df2b9fdbe34b92a857d","type":"text","conversion_output":true,"text":"benefit, it is important that the study be adequately powered to detect significant differences in","text_display":" benefit, it is important that the study be adequately powered to detect significant differences in","confidence":1,"confidence_rate":1},{"cnt":[[245,2153],[1882,2153],[1882,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2152,"width":1639,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62d35a9176e64cf48f40a624d0555cdb","type":"text","conversion_output":true,"text":"normalized WOMAC scores. With 76 evaluable subjects per treatment group, the power to show","text_display":" normalized WOMAC scores. With 76 evaluable subjects per treatment group, the power to show","confidence":1,"confidence_rate":1},{"cnt":[[245,2202],[1882,2202],[1882,2254],[245,2254]],"region":{"top_left_x":244,"top_left_y":2202,"width":1639,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6dc367593b0542789496dc99e2a92912","type":"text","conversion_output":true,"text":"a statistically significant difference between at least one active treatment group and the placebo","text_display":" a statistically significant difference between at least one active treatment group and the placebo","confidence":1,"confidence_rate":1},{"cnt":[[245,2252],[1884,2252],[1884,2301],[245,2301]],"region":{"top_left_x":244,"top_left_y":2251,"width":1641,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8673d0f55ef84f6a9af919cbe842a4b4","type":"text","conversion_output":true,"text":"group for the secondary WOMAC endpoints ranges from \\(69 \\%\\) to \\(87 \\%\\) for the total score, from","text_display":" group for the secondary WOMAC endpoints ranges from \\(69 \\%\\) to \\(87 \\%\\) for the total score, from","confidence":1,"confidence_rate":1},{"cnt":[[245,2299],[1884,2299],[1884,2348],[245,2348]],"region":{"top_left_x":244,"top_left_y":2298,"width":1641,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2ec30a1cb27478f809f0f5ed8345aa4","type":"text","conversion_output":true,"text":"\\(80 \\%\\) to \\(99 \\%\\) for the pain score and from \\(53 \\%\\) to \\(83 \\%\\) for the function score, depending on the","text_display":" \\(80 \\%\\) to \\(99 \\%\\) for the pain score and from \\(53 \\%\\) to \\(83 \\%\\) for the function score, depending on the","confidence":0.9926848383620381,"confidence_rate":0.9999287205149214},{"cnt":[[245,2346],[1154,2346],[1154,2400],[245,2400]],"region":{"top_left_x":244,"top_left_y":2346,"width":910,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e395a2e324c94cfa91c2a271aaa40266","type":"text","conversion_output":true,"text":"expected mean difference from placebo (see Table 3).","text_display":" expected mean difference from placebo (see Table 3).","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"834ea64e8a90461fb2adc3d41673aded","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2548],[389,2543],[390,2585],[245,2589]],"region":{"top_left_x":243,"top_left_y":2543,"width":148,"height":47},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"14031c7143604b4c8de90a781ee1a1ab","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb5660471dcd4315bed7f5f0a9337d49","type":"page_info","conversion_output":false,"text":"85/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2610],[1796,2610]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":111},"line":27,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"8e01ba4a37814d539c239f816dc2552a","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.9990234375,"confidence_rate":0.9998371733163992}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-086","page":86,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7cc35c6509684bae9219dd03978a6f74","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b394561c7d80498d920138c305a385e6","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee9bfe57e75e4b77a59821c9c8c7444a","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,279],[1882,279],[1882,333],[243,333]],"region":{"top_left_x":242,"top_left_y":279,"width":1641,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d31e7f00d84a4662b807eb9a6e4c65db","type":"text","conversion_output":true,"text":"Table 3 Power Calculations for Pairwise Differences (Sprifermin versus","text_display":"\n\nTable 3 Power Calculations for Pairwise Differences (Sprifermin versus","confidence":0.9157489164833237,"confidence_rate":0.9988722638021142},{"cnt":[[593,331],[1882,331],[1882,380],[593,380]],"region":{"top_left_x":592,"top_left_y":330,"width":1291,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2cdf2e67926240229a5369b9fe3f5cb3","type":"text","conversion_output":true,"text":"Placebo) on Normalized WOMAC Scores with 76 Evaluable Subjects","text_display":" Placebo) on Normalized WOMAC Scores with 76 Evaluable Subjects","confidence":0.9917159080505371,"confidence_rate":0.9998811699790423},{"cnt":[[593,378],[995,378],[995,432],[593,432]],"region":{"top_left_x":592,"top_left_y":378,"width":403,"height":54},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31c9fb887ea040a89f07ed249b812e87","type":"text","conversion_output":true,"text":"per Treatment Group","text_display":" per Treatment Group","confidence":1,"confidence_rate":1},{"cnt":[[243,458],[1863,458],[1863,990],[243,990]],"region":{"top_left_x":242,"top_left_y":457,"width":1621,"height":534},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f1f8b309f634615a7b9f453ceb0ec7e","type":"table","conversion_output":true,"children_ids":["096f2f255cc242ce92cf72148ffc46d7","4c9b550c879247489cd4d87bfe0602e3","40fb88b5c7f447858038838407688672","4a6e35166a20419395ebac13bef4d4d8","008d0d6ac2414a4f825d02708a8e79d8","ac51a2dcb994410f8d9a6362ed6af1a3","d7e6d18f58094cceb8bf2bd8f57a4bcd","d2f65a7ca445471d8e08109643050857","5c8f3ce11b5941c09b22def6b30b8d03","105b969e83da4a84922e99849f1f94f0","18af66c9588c4566badb1e69a36770ac","d44cc0dbef694d81a324469b4b66382b","60a36eeb378649a08e8c603da6ab3487","3d3337c3fb0c4f6eaf399c9e2f87441b","fdc4fa0a223c439a8261aa6e7a041760","e973d3b451af41248d2e90e0119e9772","f639c5ff3eb44c04abb0d108012fdb22","1b5bae12768541a6919ef7da7e025843","d47e461c800640db85ad77ae0cc66586","2f034c7510c947e2ad759c0de335e444","4e71bddcde3d411fa092f5f6be9bb4df","72742b6746e74b508e1fc03a7b39cbd9","cd2b9acda45f49a49589da291d1579b6","d16aeb213d0042cea1c4c74035ff493c","ee402c10beaa4dea9917496e2879d1bc","b2787e8dea3d4a64b6754d33c5e8ee6e","8cf18c65b3204122a42248121c43b7c7","81876603c40e41f4832f5ca24260f2ba","03fc4c175f654e17bf1fb21457086d68","8d11f24c62d44db88191935f14b5ac93","a66ccd5bef2b4b9a8affc5c48e03bff0","0f32e44852df4911a68de88379be2989","7756aea0e8e0469787742227df747f40","56737d1605034f6a8d0eb780153fe036","13c5269bc790499bb2fc8b02b947b38c","74b0865a670248e0b549c61983d5892c","6da45f512e474619ab941a0ab00a5c09","4ab4089cd59c4063884fa98256759679"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline & Expected mean difference from Placebo & Common SD & Power \\\\\n\\hline \\multirow{3}{*}{Total Score - Normalized (range 0-100 points)} & 8 points & \\multirow[t]{3}{*}{20} & 69\\% \\\\\n\\hline & 9 points & & 79\\% \\\\\n\\hline & 10 points & & 87\\% \\\\\n\\hline \\multirow{2}{*}{Pain Score - Normalized (range 0-100 points)} & 10 points & \\multirow[t]{2}{*}{22} & 80\\% \\\\\n\\hline & 15 points & & 99\\% \\\\\n\\hline \\multirow{3}{*}{Function Score - Normalized (range 0-100 points)} & 7 points & \\multirow[t]{3}{*}{21} & 53\\% \\\\\n\\hline & 9 points & & 75\\% \\\\\n\\hline & 10 points & & 83\\% \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|}\n\\hline & Expected mean difference from Placebo & Common SD & Power \\\\\n\\hline \\multirow{3}{*}{Total Score - Normalized (range 0-100 points)} & 8 points & \\multirow[t]{3}{*}{20} & 69\\% \\\\\n\\hline & 9 points & & 79\\% \\\\\n\\hline & 10 points & & 87\\% \\\\\n\\hline \\multirow{2}{*}{Pain Score - Normalized (range 0-100 points)} & 10 points & \\multirow[t]{2}{*}{22} & 80\\% \\\\\n\\hline & 15 points & & 99\\% \\\\\n\\hline \\multirow{3}{*}{Function Score - Normalized (range 0-100 points)} & 7 points & \\multirow[t]{3}{*}{21} & 53\\% \\\\\n\\hline & 9 points & & 75\\% \\\\\n\\hline & 10 points & & 83\\% \\\\\n\\hline\n\\end{tabular}","confidence":1,"confidence_rate":1},{"cnt":[[261,457],[671,457],[671,992],[261,992]],"region":{"top_left_x":261,"top_left_y":457,"width":410,"height":535},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"096f2f255cc242ce92cf72148ffc46d7","type":"table_column","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[729,457],[1208,457],[1208,992],[729,992]],"region":{"top_left_x":729,"top_left_y":457,"width":479,"height":535},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c9b550c879247489cd4d87bfe0602e3","type":"table_column","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[1286,457],[1483,457],[1483,992],[1286,992]],"region":{"top_left_x":1285,"top_left_y":457,"width":198,"height":535},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40fb88b5c7f447858038838407688672","type":"table_column","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[1634,457],[1741,457],[1741,992],[1634,992]],"region":{"top_left_x":1634,"top_left_y":457,"width":107,"height":535},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a6e35166a20419395ebac13bef4d4d8","type":"table_column","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[242,478],[1864,476],[1864,552],[242,554]],"region":{"top_left_x":241,"top_left_y":475,"width":1624,"height":80},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"008d0d6ac2414a4f825d02708a8e79d8","type":"table_row","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[242,574],[1862,574],[1862,617],[242,617]],"region":{"top_left_x":242,"top_left_y":573,"width":1620,"height":45},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac51a2dcb994410f8d9a6362ed6af1a3","type":"table_row","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[560,609],[558,611],[554,611],[552,613],[547,613],[545,611],[539,611],[537,613],[530,613],[528,611],[519,611],[517,613],[515,613],[513,611],[485,611],[482,613],[478,613],[476,611],[469,611],[467,613],[459,613],[456,611],[452,611],[450,613],[387,613],[385,611],[383,613],[365,613],[363,615],[352,615],[350,613],[346,613],[344,615],[322,615],[320,617],[318,615],[307,615],[305,617],[274,617],[272,615],[253,615],[251,617],[248,617],[246,619],[246,622],[244,624],[242,624],[242,671],[374,671],[376,669],[387,669],[389,671],[409,671],[411,669],[422,669],[424,671],[487,671],[489,669],[491,671],[495,671],[498,669],[524,669],[526,671],[597,671],[599,669],[610,669],[612,671],[617,671],[619,669],[625,669],[627,671],[660,671],[662,669],[664,669],[666,671],[669,669],[723,669],[725,671],[816,671],[818,669],[820,669],[822,671],[833,671],[835,669],[838,669],[840,671],[848,671],[851,669],[855,669],[857,671],[876,671],[879,669],[907,669],[909,671],[911,671],[913,669],[915,669],[918,671],[920,671],[922,669],[967,669],[970,671],[1041,671],[1043,669],[1045,671],[1221,671],[1223,669],[1264,669],[1266,671],[1273,671],[1275,669],[1279,669],[1281,671],[1498,671],[1500,669],[1509,669],[1511,671],[1513,671],[1515,669],[1860,669],[1862,667],[1862,648],[1864,645],[1862,643],[1862,626],[1857,622],[1855,624],[1853,624],[1851,626],[1741,626],[1738,624],[1736,626],[1383,626],[1381,624],[1377,624],[1375,626],[1305,626],[1303,624],[1288,624],[1286,626],[1277,626],[1275,624],[1234,624],[1232,626],[1229,626],[1227,624],[1216,624],[1214,626],[1212,626],[1210,624],[1208,624],[1206,626],[1203,624],[1199,624],[1197,626],[1171,626],[1169,624],[1164,624],[1162,626],[1160,626],[1158,624],[1147,624],[1145,626],[1143,626],[1141,624],[1130,624],[1128,626],[1126,626],[1123,624],[1113,624],[1110,626],[1108,626],[1106,624],[1104,624],[1102,626],[1089,626],[1087,624],[1084,626],[1082,626],[1080,624],[1078,626],[1074,626],[1071,624],[1061,624],[1058,626],[1022,626],[1019,624],[1011,624],[1009,626],[1002,626],[1000,624],[998,626],[996,626],[993,624],[991,626],[987,626],[985,624],[963,624],[961,626],[959,624],[957,626],[950,626],[948,624],[946,626],[881,626],[879,624],[876,626],[757,626],[755,624],[753,624],[751,626],[705,626],[703,624],[686,624],[684,622],[684,619],[679,615],[677,615],[675,613],[673,615],[669,615],[666,613],[636,613],[634,611],[630,611],[627,609],[614,609],[612,611],[597,611],[595,609],[593,609],[591,611],[582,611],[580,609],[575,609],[573,611],[562,611]],"region":{"top_left_x":242,"top_left_y":608,"width":1622,"height":64},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7e6d18f58094cceb8bf2bd8f57a4bcd","type":"table_row","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[242,678],[1864,678],[1864,721],[242,721]],"region":{"top_left_x":242,"top_left_y":677,"width":1622,"height":45},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2f65a7ca445471d8e08109643050857","type":"table_row","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[242,730],[1862,730],[1862,775],[242,775]],"region":{"top_left_x":242,"top_left_y":729,"width":1620,"height":47},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c8f3ce11b5941c09b22def6b30b8d03","type":"table_row","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[242,786],[1862,786],[1862,827],[242,827]],"region":{"top_left_x":242,"top_left_y":786,"width":1620,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"105b969e83da4a84922e99849f1f94f0","type":"table_row","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[242,838],[1864,838],[1864,879],[242,879]],"region":{"top_left_x":242,"top_left_y":838,"width":1622,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18af66c9588c4566badb1e69a36770ac","type":"table_row","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[387,877],[385,879],[381,879],[381,881],[383,884],[396,884],[398,886],[398,888],[396,890],[389,890],[387,888],[383,888],[381,890],[363,890],[361,892],[359,892],[357,890],[348,890],[346,892],[339,892],[337,890],[331,890],[329,892],[320,892],[318,890],[313,890],[311,892],[283,892],[281,890],[279,890],[277,892],[264,892],[261,894],[259,892],[255,892],[253,894],[242,894],[242,933],[248,933],[251,936],[253,933],[261,933],[264,931],[266,933],[287,933],[290,931],[1860,931],[1862,929],[1862,892],[1860,890],[1567,890],[1565,892],[1563,892],[1561,890],[1559,890],[1556,892],[1554,892],[1552,890],[1550,890],[1548,892],[1546,892],[1543,890],[1485,890],[1483,892],[1450,892],[1448,890],[1446,892],[1440,892],[1437,890],[1435,892],[1433,890],[1427,890],[1424,892],[1422,890],[1349,890],[1346,892],[1299,892],[1297,890],[889,890],[887,892],[885,892],[883,890],[853,890],[851,892],[848,892],[846,890],[840,890],[838,892],[766,892],[764,890],[671,890],[669,888],[666,890],[640,890],[638,892],[636,892],[634,890],[578,890],[573,886],[575,884],[582,884],[584,881],[591,881],[593,879],[599,879],[593,879],[591,877],[545,877],[543,879],[541,879],[539,877],[537,877],[537,879],[552,879],[554,881],[567,881],[569,884],[571,884],[573,886],[569,890],[552,890],[549,892],[547,890],[539,890],[537,892],[530,892],[528,890],[519,890],[517,892],[513,892],[511,890],[502,890],[500,892],[498,892],[495,890],[474,890],[469,886],[474,881],[478,881],[480,879],[482,881],[493,881],[495,879],[498,879],[489,879],[487,877],[485,877],[482,879],[472,879],[469,877],[441,877],[439,879],[437,879],[435,877],[433,877],[430,879],[420,879],[417,877]],"region":{"top_left_x":242,"top_left_y":877,"width":1620,"height":59},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d44cc0dbef694d81a324469b4b66382b","type":"table_row","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[242,942],[1864,942],[1864,983],[242,983]],"region":{"top_left_x":242,"top_left_y":942,"width":1622,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60a36eeb378649a08e8c603da6ab3487","type":"table_row","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"","text_display":""},{"cnt":[[731,479],[1206,479],[1206,550],[731,550]],"region":{"top_left_x":731,"top_left_y":478,"width":475,"height":73},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d3337c3fb0c4f6eaf399c9e2f87441b","type":"complex_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","children_ids":["b13ebbed8dcc4c62aaf761c125ee2c78","ab7b5715142b41e78bb38c36bda16067"],"text":"Expected mean difference from Placebo","text_display":"Expected mean difference from Placebo","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[734,483],[1206,483],[1206,518],[734,518]],"region":{"top_left_x":733,"top_left_y":482,"width":473,"height":36},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b13ebbed8dcc4c62aaf761c125ee2c78","type":"text","conversion_output":false,"parent_id":"3d3337c3fb0c4f6eaf399c9e2f87441b","text":"Expected mean difference from","text_display":"Expected mean difference from","confidence":1,"confidence_rate":1},{"cnt":[[907,518],[1032,518],[1032,550],[907,550]],"region":{"top_left_x":906,"top_left_y":517,"width":127,"height":34},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab7b5715142b41e78bb38c36bda16067","type":"text","conversion_output":false,"parent_id":"3d3337c3fb0c4f6eaf399c9e2f87441b","text":"Placebo","text_display":" Placebo","confidence":1,"confidence_rate":1},{"cnt":[[1286,483],[1483,483],[1483,515],[1286,515]],"region":{"top_left_x":1285,"top_left_y":482,"width":198,"height":34},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fdc4fa0a223c439a8261aa6e7a041760","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"Common SD","text_display":"Common SD","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1637,483],[1738,483],[1738,515],[1637,515]],"region":{"top_left_x":1636,"top_left_y":482,"width":103,"height":34},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e973d3b451af41248d2e90e0119e9772","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"Power","text_display":"Power","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[259,574],[671,574],[671,719],[259,719]],"region":{"top_left_x":259,"top_left_y":573,"width":412,"height":147},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f639c5ff3eb44c04abb0d108012fdb22","type":"table_spanning_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","children_ids":["9202f4da4a5f4f23b5ac6beaf232d44e"],"text":"","text_display":"Total Score - Normalized (range 0-100 points)","cell_row":1,"cell_column":0,"cell_row_span":3,"cell_col_span":1},{"cnt":[[264,604],[619,604],[619,693],[264,693]],"region":{"top_left_x":263,"top_left_y":604,"width":356,"height":90},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9202f4da4a5f4f23b5ac6beaf232d44e","type":"complex_cell","conversion_output":false,"parent_id":"f639c5ff3eb44c04abb0d108012fdb22","children_ids":["b22e0b28eb2444f0b9d77e05b13e47d8","49cbe39f19364140985aa310a3ad6ae4"],"text":"Total Score - Normalized (range 0-100 points)","text_display":"Total Score - Normalized (range 0-100 points)","cell_row":1,"cell_column":0,"cell_row_span":3,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[266,609],[617,609],[617,641],[266,641]],"region":{"top_left_x":265,"top_left_y":608,"width":352,"height":34},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b22e0b28eb2444f0b9d77e05b13e47d8","type":"text","conversion_output":false,"parent_id":"9202f4da4a5f4f23b5ac6beaf232d44e","text":"Total Score - Normalized","text_display":"Total Score - Normalized","confidence":1,"confidence_rate":1},{"cnt":[[268,652],[556,652],[556,689],[268,689]],"region":{"top_left_x":267,"top_left_y":651,"width":289,"height":38},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49cbe39f19364140985aa310a3ad6ae4","type":"text","conversion_output":false,"parent_id":"9202f4da4a5f4f23b5ac6beaf232d44e","text":"(range 0-100 points)","text_display":" (range 0-100 points)","confidence":1,"confidence_rate":1},{"cnt":[[911,578],[1028,578],[1028,615],[911,615]],"region":{"top_left_x":911,"top_left_y":578,"width":118,"height":38},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b5bae12768541a6919ef7da7e025843","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"8 points","text_display":"8 points","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1284,574],[1487,574],[1487,719],[1284,719]],"region":{"top_left_x":1283,"top_left_y":573,"width":205,"height":147},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d47e461c800640db85ad77ae0cc66586","type":"table_spanning_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","children_ids":["ca69dca5d00e485491bf112ea8e604c4"],"text":"","text_display":"20","cell_row":1,"cell_column":2,"cell_row_span":3,"cell_col_span":1},{"cnt":[[1362,578],[1414,578],[1414,613],[1362,613]],"region":{"top_left_x":1361,"top_left_y":578,"width":53,"height":35},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca69dca5d00e485491bf112ea8e604c4","type":"simple_cell","conversion_output":false,"parent_id":"d47e461c800640db85ad77ae0cc66586","text":"20","text_display":"20","cell_row":1,"cell_column":2,"cell_row_span":3,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1654,578],[1723,578],[1723,613],[1654,613]],"region":{"top_left_x":1653,"top_left_y":578,"width":71,"height":35},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f034c7510c947e2ad759c0de335e444","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"69\\%","text_display":"69\\%","cell_row":1,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[913,630],[1028,630],[1028,667],[913,667]],"region":{"top_left_x":913,"top_left_y":630,"width":116,"height":38},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e71bddcde3d411fa092f5f6be9bb4df","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"9 points","text_display":"9 points","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1654,630],[1723,630],[1723,665],[1654,665]],"region":{"top_left_x":1653,"top_left_y":630,"width":71,"height":35},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72742b6746e74b508e1fc03a7b39cbd9","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"79\\%","text_display":"79\\%","cell_row":2,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[896,682],[1041,682],[1041,719],[896,719]],"region":{"top_left_x":895,"top_left_y":682,"width":147,"height":38},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd2b9acda45f49a49589da291d1579b6","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"10 points","text_display":"10 points","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1654,682],[1723,682],[1723,717],[1654,717]],"region":{"top_left_x":1653,"top_left_y":682,"width":71,"height":35},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d16aeb213d0042cea1c4c74035ff493c","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"87\\%","text_display":"87\\%","cell_row":3,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[261,730],[671,730],[671,823],[261,823]],"region":{"top_left_x":261,"top_left_y":729,"width":410,"height":94},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee402c10beaa4dea9917496e2879d1bc","type":"table_spanning_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","children_ids":["57f7545ed4934cc3871245cb49eb7ef4"],"text":"","text_display":"Pain Score - Normalized (range 0-100 points)","cell_row":4,"cell_column":0,"cell_row_span":2,"cell_col_span":1},{"cnt":[[264,736],[612,736],[612,823],[264,823]],"region":{"top_left_x":263,"top_left_y":736,"width":350,"height":87},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57f7545ed4934cc3871245cb49eb7ef4","type":"complex_cell","conversion_output":false,"parent_id":"ee402c10beaa4dea9917496e2879d1bc","children_ids":["a3871e43f1c74b2eb3a93a39661e2df8","ad1b60464cc34df8850968982f7fd335"],"text":"Pain Score - Normalized (range 0-100 points)","text_display":"Pain Score - Normalized (range 0-100 points)","cell_row":4,"cell_column":0,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[268,739],[608,739],[608,771],[268,771]],"region":{"top_left_x":267,"top_left_y":738,"width":341,"height":33},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3871e43f1c74b2eb3a93a39661e2df8","type":"text","conversion_output":false,"parent_id":"57f7545ed4934cc3871245cb49eb7ef4","text":"Pain Score - Normalized","text_display":"Pain Score - Normalized","confidence":1,"confidence_rate":1},{"cnt":[[268,782],[556,782],[556,819],[268,819]],"region":{"top_left_x":267,"top_left_y":781,"width":289,"height":38},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad1b60464cc34df8850968982f7fd335","type":"text","conversion_output":false,"parent_id":"57f7545ed4934cc3871245cb49eb7ef4","text":"(range 0-100 points)","text_display":" (range 0-100 points)","confidence":1,"confidence_rate":1},{"cnt":[[900,734],[1041,734],[1041,771],[900,771]],"region":{"top_left_x":900,"top_left_y":734,"width":142,"height":37},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2787e8dea3d4a64b6754d33c5e8ee6e","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"10 points","text_display":"10 points","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1286,730],[1485,730],[1485,823],[1286,823]],"region":{"top_left_x":1285,"top_left_y":729,"width":200,"height":94},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cf18c65b3204122a42248121c43b7c7","type":"table_spanning_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","children_ids":["271f2dbc7bf14814888ae2ece9592d0b"],"text":"","text_display":"22","cell_row":4,"cell_column":2,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1362,734],[1414,734],[1414,769],[1362,769]],"region":{"top_left_x":1361,"top_left_y":734,"width":53,"height":35},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"271f2dbc7bf14814888ae2ece9592d0b","type":"simple_cell","conversion_output":false,"parent_id":"8cf18c65b3204122a42248121c43b7c7","text":"22","text_display":"22","cell_row":4,"cell_column":2,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1654,734],[1723,734],[1723,769],[1654,769]],"region":{"top_left_x":1653,"top_left_y":734,"width":71,"height":35},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81876603c40e41f4832f5ca24260f2ba","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"80\\%","text_display":"80\\%","cell_row":4,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[905,788],[1035,788],[1035,823],[905,823]],"region":{"top_left_x":904,"top_left_y":788,"width":131,"height":35},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03fc4c175f654e17bf1fb21457086d68","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"15 points","text_display":"15 points","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1654,788],[1723,788],[1723,821],[1654,821]],"region":{"top_left_x":1653,"top_left_y":788,"width":71,"height":33},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d11f24c62d44db88191935f14b5ac93","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"99\\%","text_display":"99\\%","cell_row":5,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[264,838],[671,838],[671,983],[264,983]],"region":{"top_left_x":263,"top_left_y":838,"width":408,"height":146},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a66ccd5bef2b4b9a8affc5c48e03bff0","type":"table_spanning_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","children_ids":["442bdda066f84161996d68e93b4afde6"],"text":"","text_display":"Function Score - Normalized (range 0-100 points)","cell_row":6,"cell_column":0,"cell_row_span":3,"cell_col_span":1},{"cnt":[[266,868],[669,868],[669,953],[266,953]],"region":{"top_left_x":265,"top_left_y":868,"width":404,"height":85},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"442bdda066f84161996d68e93b4afde6","type":"complex_cell","conversion_output":false,"parent_id":"a66ccd5bef2b4b9a8affc5c48e03bff0","children_ids":["35ab62f856c840c69ce2f5e4251a2d66","d08acb1a510a4af184d6691ed12fca21"],"text":"Function Score - Normalized (range 0-100 points)","text_display":"Function Score - Normalized (range 0-100 points)","cell_row":6,"cell_column":0,"cell_row_span":3,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[268,873],[669,873],[669,903],[268,903]],"region":{"top_left_x":267,"top_left_y":872,"width":402,"height":32},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35ab62f856c840c69ce2f5e4251a2d66","type":"text","conversion_output":false,"parent_id":"442bdda066f84161996d68e93b4afde6","text":"Function Score - Normalized","text_display":"Function Score - Normalized","confidence":1,"confidence_rate":1},{"cnt":[[268,912],[552,912],[552,951],[268,951]],"region":{"top_left_x":267,"top_left_y":911,"width":285,"height":40},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d08acb1a510a4af184d6691ed12fca21","type":"text","conversion_output":false,"parent_id":"442bdda066f84161996d68e93b4afde6","text":"(range 0-100 points)","text_display":" (range 0-100 points)","confidence":1,"confidence_rate":1},{"cnt":[[911,840],[1026,840],[1026,875],[911,875]],"region":{"top_left_x":911,"top_left_y":840,"width":115,"height":35},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f32e44852df4911a68de88379be2989","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"7 points","text_display":"7 points","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1286,838],[1485,838],[1485,983],[1286,983]],"region":{"top_left_x":1285,"top_left_y":838,"width":200,"height":146},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7756aea0e8e0469787742227df747f40","type":"table_spanning_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","children_ids":["506354b1f0c5437091eda951e72504bf"],"text":"","text_display":"21","cell_row":6,"cell_column":2,"cell_row_span":3,"cell_col_span":1},{"cnt":[[1362,842],[1403,842],[1403,873],[1362,873]],"region":{"top_left_x":1361,"top_left_y":842,"width":42,"height":31},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"506354b1f0c5437091eda951e72504bf","type":"simple_cell","conversion_output":false,"parent_id":"7756aea0e8e0469787742227df747f40","text":"21","text_display":"21","cell_row":6,"cell_column":2,"cell_row_span":3,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1654,840],[1723,840],[1723,873],[1654,873]],"region":{"top_left_x":1653,"top_left_y":840,"width":71,"height":33},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56737d1605034f6a8d0eb780153fe036","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"53\\%","text_display":"53\\%","cell_row":6,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[913,894],[1026,894],[1026,929],[913,929]],"region":{"top_left_x":913,"top_left_y":894,"width":113,"height":36},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13c5269bc790499bb2fc8b02b947b38c","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"9 points","text_display":"9 points","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1654,894],[1723,894],[1723,929],[1654,929]],"region":{"top_left_x":1653,"top_left_y":894,"width":71,"height":36},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74b0865a670248e0b549c61983d5892c","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"75\\%","text_display":"75\\%","cell_row":7,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[900,946],[1041,946],[1041,979],[900,979]],"region":{"top_left_x":900,"top_left_y":946,"width":142,"height":33},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6da45f512e474619ab941a0ab00a5c09","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"10 points","text_display":"10 points","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1654,946],[1723,946],[1723,977],[1654,977]],"region":{"top_left_x":1653,"top_left_y":946,"width":71,"height":31},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ab4089cd59c4063884fa98256759679","type":"simple_cell","conversion_output":false,"parent_id":"3f1f8b309f634615a7b9f453ceb0ec7e","text":"83\\%","text_display":"83\\%","cell_row":8,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,984],[1618,984],[1618,1029],[245,1029]],"region":{"top_left_x":244,"top_left_y":983,"width":1374,"height":47},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f2090b94be949bfb9cbb522bdae5e13","type":"text","conversion_output":true,"text":"SD: standard deviation; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index","text_display":"\n\nSD: standard deviation; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index","confidence":0.9985356330871582,"confidence_rate":0.9999850466409257},{"cnt":[[245,1066],[1882,1066],[1882,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1065,"width":1639,"height":55},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b2a18b78f6841ef819ee7db5250a0c9","type":"text","conversion_output":true,"text":"For reference, a difference of 10 points from placebo in the normalized WOMAC scores is","text_display":"\nFor reference, a difference of 10 points from placebo in the normalized WOMAC scores is","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1113],[1489,1113],[1489,1167],[245,1167]],"region":{"top_left_x":244,"top_left_y":1112,"width":1245,"height":55},"line":62,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e8794236fc946039cf090b83fca3fe4","type":"text","conversion_output":true,"text":"considered as clinically meaningful (highlighted in bold type in the table).","text_display":" considered as clinically meaningful (highlighted in bold type in the table).","confidence":1,"confidence_rate":1},{"cnt":[[236,1199],[932,1199],[932,1265],[236,1265]],"region":{"top_left_x":236,"top_left_y":1198,"width":697,"height":68},"line":63,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8ebd3aa63004226830a9186abbb3cae","type":"section_header","conversion_output":false,"children_ids":["6c37f896dea64e3a84cdfa3e4b8932b3"],"text":"","text_display":""},{"cnt":[[245,1258],[245,1205],[926,1207],[926,1260]],"region":{"top_left_x":244,"top_left_y":1205,"width":683,"height":56},"line":64,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c37f896dea64e3a84cdfa3e4b8932b3","type":"text","conversion_output":true,"parent_id":"b8ebd3aa63004226830a9186abbb3cae","text":"8.2 Randomization","text_display":"\n\n\\subsection*{8.2 Randomization}","confidence":0.9224381446838379,"confidence_rate":0.9963369545999153},{"cnt":[[245,1300],[1880,1300],[1880,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1299,"width":1636,"height":53},"line":65,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"841f2cd50ef54246bd4267f8355631cc","type":"text","conversion_output":true,"text":"Randomization will be coordinated centrally, using an IVRS system which will allocate subjects","text_display":"\n\nRandomization will be coordinated centrally, using an IVRS system which will allocate subjects","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1880,1349],[1880,1401],[245,1401]],"region":{"top_left_x":244,"top_left_y":1349,"width":1636,"height":52},"line":66,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31d4ecf9bc564ff0ac0f3d431dad1824","type":"text","conversion_output":true,"text":"to the treatment groups (see Section 6.3 for further details concerning the technical and logistical","text_display":" to the treatment groups (see Section 6.3 for further details concerning the technical and logistical","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[784,1396],[784,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1396,"width":541,"height":55},"line":67,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"593825450c9f494b8d42ae3e16609ac5","type":"text","conversion_output":true,"text":"aspects of treatment allocation).","text_display":" aspects of treatment allocation).","confidence":0.99951171875,"confidence_rate":0.9999871474379078},{"cnt":[[245,1487],[1886,1487],[1886,1538],[245,1538]],"region":{"top_left_x":244,"top_left_y":1486,"width":1643,"height":53},"line":68,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"033078d6b7084f27a1b596aa3e8ac867","type":"text","conversion_output":true,"text":"Eligible subjects will be randomized to one of the 5 treatment groups with an allocation ratio of","text_display":"\n\nEligible subjects will be randomized to one of the 5 treatment groups with an allocation ratio of","confidence":0.9990234375,"confidence_rate":0.9999906949037896},{"cnt":[[245,1534],[1678,1534],[1678,1588],[245,1588]],"region":{"top_left_x":244,"top_left_y":1533,"width":1434,"height":55},"line":69,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41ac4e4ff34d4ddf9fe3a93ad9be9dad","type":"text","conversion_output":true,"text":"\\(1: 1: 1: 1: 1\\), using a computer-generated randomization list in random permuted blocks.","text_display":" \\(1: 1: 1: 1: 1\\), using a computer-generated randomization list in random permuted blocks.","confidence":0.63720703125,"confidence_rate":0.9948919467652263},{"cnt":[[245,1624],[1880,1624],[1880,1676],[245,1676]],"region":{"top_left_x":244,"top_left_y":1624,"width":1636,"height":52},"line":70,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42e725a9f20a44efbdc7ac35c98a3ad6","type":"text","conversion_output":true,"text":"Randomization will be stratified by country to ensure balance of treatment groups with respect to","text_display":"\n\nRandomization will be stratified by country to ensure balance of treatment groups with respect to","confidence":1,"confidence_rate":1},{"cnt":[[245,1671],[1880,1671],[1880,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1671,"width":1636,"height":55},"line":71,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9713ebecb9be44ddb9cf6a7b5f1c8729","type":"text","conversion_output":true,"text":"intrinsic and extrinsic factors that may affect OA outcomes. Moreover, it may not be practical to","text_display":" intrinsic and extrinsic factors that may affect OA outcomes. Moreover, it may not be practical to","confidence":0.99658203125,"confidence_rate":0.999966433667778},{"cnt":[[245,1719],[1755,1719],[1755,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1718,"width":1512,"height":55},"line":72,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e75c9792bee84215a0edad1ab4d2c99e","type":"text","conversion_output":true,"text":"stratify randomization by site as numbers of subjects in each site are expected to be small.","text_display":" stratify randomization by site as numbers of subjects in each site are expected to be small.","confidence":1,"confidence_rate":1},{"cnt":[[236,1805],[827,1805],[827,1876],[236,1876]],"region":{"top_left_x":236,"top_left_y":1804,"width":592,"height":72},"line":73,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"fd14aace3b47453babc19ec05342e800","type":"section_header","conversion_output":false,"children_ids":["be7a7adcea80424c831f9f1394499bff"],"text":"","text_display":""},{"cnt":[[245,1813],[819,1813],[819,1871],[245,1871]],"region":{"top_left_x":244,"top_left_y":1813,"width":575,"height":59},"line":74,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"be7a7adcea80424c831f9f1394499bff","type":"text","conversion_output":true,"parent_id":"fd14aace3b47453babc19ec05342e800","text":"8.3 Endpoints","text_display":"\n\n\\subsection*{8.3 Endpoints}","confidence":0.99462890625,"confidence_rate":0.9997008464257681},{"cnt":[[236,1904],[995,1904],[995,1974],[236,1974]],"region":{"top_left_x":236,"top_left_y":1903,"width":759,"height":72},"line":75,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd82f0b45e4141b2a482e05167bdf6d8","type":"section_header","conversion_output":false,"children_ids":["1d5db420793241bf9cddb849dea735d7"],"text":"","text_display":""},{"cnt":[[245,1908],[990,1908],[990,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1907,"width":747,"height":64},"line":76,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d5db420793241bf9cddb849dea735d7","type":"text","conversion_output":true,"parent_id":"dd82f0b45e4141b2a482e05167bdf6d8","text":"8.3.1 Primary Endpoint","text_display":"\n\n\\subsection*{8.3.1 Primary Endpoint}","confidence":0.99267578125,"confidence_rate":0.9997277714116302},{"cnt":[[245,2002],[1880,2002],[1880,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2002,"width":1636,"height":55},"line":77,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08c8d169017e466b8a349ba8bd0d9334","type":"text","conversion_output":true,"text":"The primary endpoint of this trial is the change from baseline in cartilage thickness in the total","text_display":"\n\nThe primary endpoint of this trial is the change from baseline in cartilage thickness in the total","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1085,2054],[1085,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2053,"width":841,"height":51},"line":78,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dfdd28262f54ae6b00dfef8675d12dd","type":"text","conversion_output":true,"text":"femorotibial joint as evaluated by MRI at 2 years.","text_display":" femorotibial joint as evaluated by MRI at 2 years.","confidence":1,"confidence_rate":1},{"cnt":[[236,2136],[1057,2136],[1057,2211],[236,2211]],"region":{"top_left_x":236,"top_left_y":2135,"width":822,"height":76},"line":79,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b54f7b09da8649c4b2d881ecdec7ebae","type":"section_header","conversion_output":false,"children_ids":["155be027fd46439f937e753e2f0236d5"],"text":"","text_display":""},{"cnt":[[245,2144],[1051,2144],[1051,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2144,"width":807,"height":59},"line":80,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"155be027fd46439f937e753e2f0236d5","type":"text","conversion_output":true,"parent_id":"b54f7b09da8649c4b2d881ecdec7ebae","text":"8.3.2 Secondary Endpoints","text_display":"\n\n\\subsection*{8.3.2 Secondary Endpoints}","confidence":0.9921875,"confidence_rate":0.9997385949235614},{"cnt":[[245,2239],[819,2239],[819,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2238,"width":575,"height":55},"line":81,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea055d834fa648b5a52c0780535b78de","type":"text","conversion_output":true,"text":"Secondary efficacy endpoints are:","text_display":"\n\nSecondary efficacy endpoints are:","confidence":1,"confidence_rate":1},{"cnt":[[245,2307],[1880,2307],[1880,2363],[245,2363]],"region":{"top_left_x":244,"top_left_y":2307,"width":1636,"height":57},"line":82,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d7d7deefba04a448f07290f76b3ab6f","type":"text","conversion_output":true,"text":"- Changes from baseline in the WOMAC total score and in the WOMAC pain, function, and","text_display":"\n- Changes from baseline in the WOMAC total score and in the WOMAC pain, function, and","confidence":1,"confidence_rate":1},{"cnt":[[294,2359],[874,2359],[874,2413],[294,2413]],"region":{"top_left_x":294,"top_left_y":2358,"width":581,"height":55},"line":83,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da6d7ba912924316989fb411afc96c63","type":"text","conversion_output":true,"text":"stiffness index scores over 2 years","text_display":" stiffness index scores over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,2430],[1308,2430],[1308,2484],[245,2484]],"region":{"top_left_x":244,"top_left_y":2429,"width":1065,"height":55},"line":84,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"296c6abeaaa3460fa60ab53a321ff4f9","type":"text","conversion_output":true,"text":"- Change from baseline in the 20 -meter walk test over 2 years","text_display":"\n- Change from baseline in the 20 -meter walk test over 2 years","confidence":0.9941432476043701,"confidence_rate":0.9999195378888835},{"cnt":[[245,2509],[440,2509],[440,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":197,"height":37},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b4e6cfefe5842c0bfa7a0e76b64902e","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2546],[389,2543],[390,2588],[245,2591]],"region":{"top_left_x":244,"top_left_y":2543,"width":146,"height":48},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8175ce3dfd164b4ca248a7be2fc93946","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2529],[1601,2529],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2528,"width":93,"height":36},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da878b71ae8d4bd989b114d4929ed8a9","type":"page_info","conversion_output":false,"text":"86/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-087","page":87,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a955233761943859c77f582f306b15e","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8330f20bf1ad4aaa9db293196c4458db","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d7d118d07e34003b41ecf50b643168d","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,284],[1081,284],[1081,333],[245,333]],"region":{"top_left_x":244,"top_left_y":283,"width":837,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6e1adbafb5a49f2b5aafe9189f5168f","type":"text","conversion_output":true,"text":"- Change from baseline in the PGA over 2 years","text_display":"\n- Change from baseline in the PGA over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,354],[1882,354],[1882,406],[245,406]],"region":{"top_left_x":244,"top_left_y":354,"width":1639,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efc3628703d74831ac1c0511f520dd37","type":"text","conversion_output":true,"text":"- Change from baseline in minimal JSW in the medial and lateral compartments as evaluated by","text_display":"\n- Change from baseline in minimal JSW in the medial and lateral compartments as evaluated by","confidence":1,"confidence_rate":1},{"cnt":[[292,404],[614,404],[614,453],[292,453]],"region":{"top_left_x":292,"top_left_y":403,"width":323,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c7a51529ec64257a0f719c72132a7a8","type":"text","conversion_output":true,"text":"X-ray over 2 years","text_display":" X-ray over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1880,473],[1880,526],[245,526]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4253443905d24379b00ab5719e4a2bde","type":"text","conversion_output":true,"text":"- Change from baseline in cartilage thickness in the medial and lateral compartments as well as","text_display":"\n- Change from baseline in cartilage thickness in the medial and lateral compartments as well as","confidence":1,"confidence_rate":1},{"cnt":[[294,524],[999,524],[999,574],[294,574]],"region":{"top_left_x":294,"top_left_y":524,"width":706,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3863fa4f66ae46d78e052d7300a5579c","type":"text","conversion_output":true,"text":"in the total femorotibial joint over 2 years","text_display":" in the total femorotibial joint over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,593],[1880,593],[1880,647],[245,647]],"region":{"top_left_x":244,"top_left_y":592,"width":1636,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ff3a8b965384856a3008f7e5de71d7e","type":"text","conversion_output":true,"text":"- Change from baseline in cartilage volume in the medial and lateral compartments as well as in","text_display":"\n- Change from baseline in cartilage volume in the medial and lateral compartments as well as in","confidence":1,"confidence_rate":1},{"cnt":[[292,645],[956,645],[956,694],[292,694]],"region":{"top_left_x":292,"top_left_y":644,"width":665,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b0b575d421a4994ba525450f200de00","type":"text","conversion_output":true,"text":"the total femorotibial joint over 2 years","text_display":" the total femorotibial joint over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,713],[1021,713],[1021,767],[245,767]],"region":{"top_left_x":244,"top_left_y":713,"width":777,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90f6bec011164f4f877a38991db1c83e","type":"text","conversion_output":true,"text":"- Synovial fluid levels of sprifermin/FGF-18","text_display":"\n- Synovial fluid levels of sprifermin/FGF-18","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[892,786],[892,838],[245,838]],"region":{"top_left_x":244,"top_left_y":786,"width":648,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"333882b1ab2440da8713cfe644801469","type":"text","conversion_output":true,"text":"- Serum levels of sprifermin/FGF-18","text_display":"\n- Serum levels of sprifermin/FGF-18","confidence":1,"confidence_rate":1},{"cnt":[[236,872],[967,872],[967,943],[236,943]],"region":{"top_left_x":236,"top_left_y":872,"width":731,"height":72},"line":13,"column":0,"font_size":40,"is_printed":true,"is_handwritten":false,"id":"678ce9f57da64427953777370a37eff7","type":"section_header","conversion_output":false,"children_ids":["7ee6ccfeda8043f1801e4b746b2b777a","b4634255eaf9440d80f15697d745d374"],"text":"","text_display":""},{"cnt":[[245,879],[350,879],[350,930],[245,930]],"region":{"top_left_x":244,"top_left_y":878,"width":107,"height":53},"line":14,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"7ee6ccfeda8043f1801e4b746b2b777a","type":"text","conversion_output":true,"parent_id":"678ce9f57da64427953777370a37eff7","text":"8.3.3","text_display":"\n\n\\subsection*{8.3.3","confidence":1,"confidence_rate":1},{"cnt":[[593,881],[960,881],[960,935],[593,935]],"region":{"top_left_x":592,"top_left_y":880,"width":369,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4634255eaf9440d80f15697d745d374","type":"text","conversion_output":true,"parent_id":"678ce9f57da64427953777370a37eff7","text":"Safety Endpoints","text_display":" Safety Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[245,973],[604,973],[604,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":973,"width":360,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa4ae3dcea7b4a7bb9af89a9a274d99e","type":"text","conversion_output":true,"text":"Safety endpoints are:","text_display":"\n\nSafety endpoints are:","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1257,1044],[1257,1096],[245,1096]],"region":{"top_left_x":244,"top_left_y":1044,"width":1013,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb5e2a32d75644658a6ac7f52b689f8d","type":"text","conversion_output":true,"text":"- Nature, incidence and severity of local and systemic AEs","text_display":"\n- Nature, incidence and severity of local and systemic AEs","confidence":1,"confidence_rate":1},{"cnt":[[245,1117],[1882,1117],[1882,1169],[245,1169]],"region":{"top_left_x":244,"top_left_y":1117,"width":1639,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"862171e0cff64424995418ce1c149997","type":"text","conversion_output":true,"text":"- Incidence of acute inflammatory reactions (AIRs), defined as increase of pain by 30 mm on a","text_display":"\n- Incidence of acute inflammatory reactions (AIRs), defined as increase of pain by 30 mm on a","confidence":1,"confidence_rate":1},{"cnt":[[296,1164],[1880,1164],[1880,1216],[296,1216]],"region":{"top_left_x":296,"top_left_y":1164,"width":1584,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46681e5f2cc8494a9adbd578147d85b3","type":"text","conversion_output":true,"text":"100 mm VAS associated with a self-reported synovial fluid effusion (i.e., joint swelling)","text_display":" 100 mm VAS associated with a self-reported synovial fluid effusion (i.e., joint swelling)","confidence":0.99609375,"confidence_rate":0.9999588019084422},{"cnt":[[294,1212],[920,1212],[920,1265],[294,1265]],"region":{"top_left_x":294,"top_left_y":1211,"width":626,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd9188d5b1b547eeb220b3b70a176db7","type":"text","conversion_output":true,"text":"within 3 days following i.a. injection","text_display":" within 3 days following i.a. injection","confidence":1,"confidence_rate":1},{"cnt":[[245,1283],[1880,1283],[1880,1336],[245,1336]],"region":{"top_left_x":244,"top_left_y":1282,"width":1636,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"623cd5299c6a4c1393e00a16c7a1d8b7","type":"text","conversion_output":true,"text":"- Changes in laboratory safety parameters, vital signs, 12-lead ECG parameters, weight, and","text_display":"\n- Changes in laboratory safety parameters, vital signs, 12-lead ECG parameters, weight, and","confidence":0.998046875,"confidence_rate":0.9999796352611579},{"cnt":[[292,1332],[677,1332],[677,1386],[292,1386]],"region":{"top_left_x":292,"top_left_y":1332,"width":385,"height":54},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37b7d1e2d064464792af866b8f97f7a6","type":"text","conversion_output":true,"text":"physical examinations","text_display":" physical examinations","confidence":1,"confidence_rate":1},{"cnt":[[245,1403],[1880,1401],[1880,1454],[245,1457]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":57},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48fb8763a61d4e8f8bad2e87513caca8","type":"text","conversion_output":true,"text":"- Incidence of surgical interventions in the target knee (including any surgical revision,","text_display":"\n- Incidence of surgical interventions in the target knee (including any surgical revision,","confidence":1,"confidence_rate":1},{"cnt":[[292,1452],[1313,1452],[1313,1502],[292,1502]],"region":{"top_left_x":292,"top_left_y":1452,"width":1021,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54f2c592133b439584f0ff31ea87a1ca","type":"text","conversion_output":true,"text":"cartilage removal, or any other type of surgical intervention)","text_display":" cartilage removal, or any other type of surgical intervention)","confidence":1,"confidence_rate":1},{"cnt":[[245,1523],[1510,1523],[1510,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1523,"width":1267,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25c78591ba83420faf262719c990e424","type":"text","conversion_output":true,"text":"- Occurrence of binding and neutralizing antibodies to sprifermin/FGF-18","text_display":"\n- Occurrence of binding and neutralizing antibodies to sprifermin/FGF-18","confidence":1,"confidence_rate":1},{"cnt":[[236,1609],[1094,1609],[1094,1680],[236,1680]],"region":{"top_left_x":236,"top_left_y":1609,"width":858,"height":72},"line":26,"column":0,"font_size":40,"is_printed":true,"is_handwritten":false,"id":"3327443581644434a8f0ab106c43e7ef","type":"section_header","conversion_output":false,"children_ids":["a08d062869d04bbbaf2772f9794d6231","c7b6385101be4653a5b18135c56fe008"],"text":"","text_display":""},{"cnt":[[245,1616],[352,1616],[352,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1615,"width":109,"height":51},"line":27,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"a08d062869d04bbbaf2772f9794d6231","type":"text","conversion_output":true,"parent_id":"3327443581644434a8f0ab106c43e7ef","text":"8.3.4","text_display":"\n\n\\subsection*{8.3.4","confidence":1,"confidence_rate":1},{"cnt":[[595,1616],[1085,1616],[1085,1674],[595,1674]],"region":{"top_left_x":595,"top_left_y":1615,"width":490,"height":59},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7b6385101be4653a5b18135c56fe008","type":"text","conversion_output":true,"parent_id":"3327443581644434a8f0ab106c43e7ef","text":"Exploratory Endpoints","text_display":" Exploratory Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[245,1710],[698,1710],[698,1764],[245,1764]],"region":{"top_left_x":244,"top_left_y":1710,"width":455,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"290b4cfb7e8b4e3d9dc86cc65607b0c4","type":"text","conversion_output":true,"text":"Exploratory endpoints are:","text_display":"\n\nExploratory endpoints are:","confidence":1,"confidence_rate":1},{"cnt":[[245,1781],[1880,1781],[1880,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1781,"width":1636,"height":54},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b82fc6047bc4c558b6b101d9a89758b","type":"text","conversion_output":true,"text":"- Outcome Measures in Rheumatology - Osteoarthritis Research Society International","text_display":"\n- Outcome Measures in Rheumatology - Osteoarthritis Research Society International","confidence":1,"confidence_rate":1},{"cnt":[[294,1830],[1154,1830],[1154,1884],[294,1884]],"region":{"top_left_x":294,"top_left_y":1830,"width":860,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71af6304270244109ce56fa57240121d","type":"text","conversion_output":true,"text":"(OMERACT-OARSI) responder rate (1) at 2 years","text_display":" (OMERACT-OARSI) responder rate (1) at 2 years","confidence":0.99560546875,"confidence_rate":0.9999169050453139},{"cnt":[[245,1904],[612,1904],[612,1953],[245,1953]],"region":{"top_left_x":244,"top_left_y":1903,"width":369,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11316799adc94b83ac3178b0b41282ec","type":"text","conversion_output":true,"text":"- PGIC over 2 years","text_display":"\n- PGIC over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,1972],[1882,1972],[1882,2026],[245,2026]],"region":{"top_left_x":244,"top_left_y":1972,"width":1639,"height":54},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6ced04d475946c595e91fec95118a1b","type":"text","conversion_output":true,"text":"- Changes from baseline in the scores of the KOOS QOL and the MOS SF-36 questionnaire","text_display":"\n- Changes from baseline in the scores of the KOOS QOL and the MOS SF-36 questionnaire","confidence":1,"confidence_rate":1},{"cnt":[[292,2024],[509,2024],[509,2073],[292,2073]],"region":{"top_left_x":292,"top_left_y":2023,"width":218,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"180576ac455e4c93adf4bd87e7a85b17","type":"text","conversion_output":true,"text":"over 2 years","text_display":" over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1328,2093],[1328,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2092,"width":1084,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48c0b09d94ba4ae88cfd2867b4bb121d","type":"text","conversion_output":true,"text":"- Change from baseline in KOOS Symptom Index over 2 years","text_display":"\n- Change from baseline in KOOS Symptom Index over 2 years","confidence":1,"confidence_rate":1},{"cnt":[[245,2166],[1880,2166],[1880,2219],[245,2219]],"region":{"top_left_x":244,"top_left_y":2165,"width":1636,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61bca6c89ed2458a8a7114efc1f56973","type":"text","conversion_output":true,"text":"- Change from baseline in pain score in the target and contralateral knee over 2 years using an","text_display":"\n- Change from baseline in pain score in the target and contralateral knee over 2 years using an","confidence":0.9990234375,"confidence_rate":0.9999905142231666},{"cnt":[[296,2213],[535,2213],[535,2264],[296,2264]],"region":{"top_left_x":296,"top_left_y":2212,"width":239,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fda061e4e3b44529b76792e5f9db26c8","type":"text","conversion_output":true,"text":"11-point NRS","text_display":" 11-point NRS","confidence":1,"confidence_rate":1},{"cnt":[[245,2286],[1452,2286],[1452,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2285,"width":1209,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bf84a33c0ce4c679eaae29d0ef50434","type":"text","conversion_output":true,"text":"- Change from baseline in presence of pain in other joints over 2 years","text_display":"\n- Change from baseline in presence of pain in other joints over 2 years","confidence":0.9990234375,"confidence_rate":0.9999876324859995},{"cnt":[[245,2355],[1175,2355],[1175,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2354,"width":932,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f19351f2d7842d28b64a1417ec0c026","type":"text","conversion_output":true,"text":"- Change from baseline in ICOAP scores over 2 years","text_display":"\n- Change from baseline in ICOAP scores over 2 years","confidence":0.99853515625,"confidence_rate":0.9999751542462456},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e203c1087634e4394ff5237108321dd","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e442d90dbb945cf82ca5857e07b9b4b","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2359aac52d814f1ea1f54a9f62505c0e","type":"page_info","conversion_output":false,"text":"87/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-088","page":88,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bb18fce631a4d4c892b112cd6c1ffc7","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65d2605182484dd291b32168fb34a98f","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a611f0c786f420dbd20858116e9554b","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,281],[1880,281],[1880,335],[245,335]],"region":{"top_left_x":244,"top_left_y":281,"width":1636,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a153cf9c8b0a489dba5a6d0e13d37610","type":"text","conversion_output":true,"text":"- Change over time in structural as well as compositional parameters of the knee joint (e.g.,","text_display":"\n- Change over time in structural as well as compositional parameters of the knee joint (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[294,331],[1442,331],[1442,382],[294,382]],"region":{"top_left_x":294,"top_left_y":330,"width":1148,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e48faa0275de49fc8ff29f777bb0f75c","type":"text","conversion_output":true,"text":"synovium, menisci, bone, and other structures) as evaluated by MRI","text_display":" synovium, menisci, bone, and other structures) as evaluated by MRI","confidence":1,"confidence_rate":1},{"cnt":[[245,402],[1884,402],[1884,453],[245,453]],"region":{"top_left_x":244,"top_left_y":401,"width":1641,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7144d6ac631a4c559be0aa992bd0356b","type":"text","conversion_output":true,"text":"- Change from baseline in serum, urine, and synovial markers associated with administration of","text_display":"\n- Change from baseline in serum, urine, and synovial markers associated with administration of","confidence":1,"confidence_rate":1},{"cnt":[[292,451],[541,451],[541,501],[292,501]],"region":{"top_left_x":292,"top_left_y":451,"width":250,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c66ac2dc9c44c77bf46a2f353fd9c1e","type":"text","conversion_output":true,"text":"the compound","text_display":" the compound","confidence":1,"confidence_rate":1},{"cnt":[[245,524],[1882,524],[1882,574],[245,574]],"region":{"top_left_x":244,"top_left_y":524,"width":1639,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6c3f5d57633439aa95afdc774fa549b","type":"text","conversion_output":true,"text":"- Baseline protein markers and/or genetic markers associated with response to treatment or","text_display":"\n- Baseline protein markers and/or genetic markers associated with response to treatment or","confidence":1,"confidence_rate":1},{"cnt":[[292,571],[1457,571],[1457,623],[292,623]],"region":{"top_left_x":292,"top_left_y":571,"width":1165,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"083cbbaab3f249c8a1e6426b6ab42916","type":"text","conversion_output":true,"text":"disease progression (response assessed by MRI and/or questionnaire)","text_display":" disease progression (response assessed by MRI and/or questionnaire)","confidence":1,"confidence_rate":1},{"cnt":[[245,642],[1880,642],[1880,694],[245,694]],"region":{"top_left_x":244,"top_left_y":642,"width":1636,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27bb92abe4b5458b8b0dcdd4998da5d4","type":"text","conversion_output":true,"text":"- Changes in MRI outcomes, WOMAC scores, 20 -meter walk test, PGA, PGIC, JSW,","text_display":"\n- Changes in MRI outcomes, WOMAC scores, 20 -meter walk test, PGA, PGIC, JSW,","confidence":0.861328125,"confidence_rate":0.9982453089254711},{"cnt":[[292,692],[1880,692],[1880,741],[292,741]],"region":{"top_left_x":292,"top_left_y":691,"width":1588,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81cbce26eab140f6807911b1a99ca093","type":"text","conversion_output":true,"text":"OMERACT-OARSI responder rate, KOOS QOL, KOOS Symptom Index, MOS SF-36, NRS","text_display":" OMERACT-OARSI responder rate, KOOS QOL, KOOS Symptom Index, MOS SF-36, NRS","confidence":1,"confidence_rate":1},{"cnt":[[292,739],[1880,739],[1880,788],[292,788]],"region":{"top_left_x":292,"top_left_y":739,"width":1588,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e94455f4a8b4dbd843359ead609abb9","type":"text","conversion_output":true,"text":"pain score in the target and contralateral knee, presence of pain in other joints, ICOAP, safety","text_display":" pain score in the target and contralateral knee, presence of pain in other joints, ICOAP, safety","confidence":1,"confidence_rate":1},{"cnt":[[294,786],[1880,786],[1880,836],[294,836]],"region":{"top_left_x":294,"top_left_y":786,"width":1586,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6166aa36c72a4b66adec59a12524f51b","type":"text","conversion_output":true,"text":"laboratory values, and vital signs over the extended follow-up period and nature, incidence","text_display":" laboratory values, and vital signs over the extended follow-up period and nature, incidence","confidence":1,"confidence_rate":1},{"cnt":[[292,834],[1880,834],[1880,885],[292,885]],"region":{"top_left_x":292,"top_left_y":833,"width":1588,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f02c904f01024488bcb37a498b2dd80e","type":"text","conversion_output":true,"text":"and severity of local and systemic AEs during the extended follow-up period (to be","text_display":" and severity of local and systemic AEs during the extended follow-up period (to be","confidence":1,"confidence_rate":1},{"cnt":[[292,883],[746,883],[746,935],[292,935]],"region":{"top_left_x":292,"top_left_y":883,"width":454,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7729730aa7a84b0294a3a739625ac39b","type":"text","conversion_output":true,"text":"summarized descriptively)","text_display":" summarized descriptively)","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1880,954],[1880,1005],[245,1005]],"region":{"top_left_x":244,"top_left_y":953,"width":1636,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f705fcf84aa149b58ed06ca8d4f3e1d6","type":"text","conversion_output":true,"text":"- Relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a","text_display":"\n- Relationship between dosing (dose and regimen), cartilage structure, and clinical scores as a","confidence":1,"confidence_rate":1},{"cnt":[[292,1001],[574,1001],[574,1046],[292,1046]],"region":{"top_left_x":292,"top_left_y":1001,"width":282,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f3c3f2acbfa45a289158765f67724d5","type":"text","conversion_output":true,"text":"function of time","text_display":" function of time","confidence":1,"confidence_rate":1},{"cnt":[[243,1091],[1880,1091],[1880,1141],[243,1141]],"region":{"top_left_x":242,"top_left_y":1091,"width":1638,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b87c8b03ef7948b687bf37b8aa42eb9f","type":"text","conversion_output":true,"text":"The Outcome Measures in Rheumatology - Osteoarthritis Research Society International","text_display":"\n\nThe Outcome Measures in Rheumatology - Osteoarthritis Research Society International","confidence":1,"confidence_rate":1},{"cnt":[[245,1139],[1880,1139],[1880,1190],[245,1190]],"region":{"top_left_x":244,"top_left_y":1138,"width":1636,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eeb195f0c11460e83d3b2f3b9da05af","type":"text","conversion_output":true,"text":"(OMERACT-OARSI) responder rate (1) will be determined as an exploratory analysis. The","text_display":" (OMERACT-OARSI) responder rate (1) will be determined as an exploratory analysis. The","confidence":1,"confidence_rate":1},{"cnt":[[245,1186],[1882,1186],[1882,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1185,"width":1639,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4428142fa7384e2b84c15dc4ded53bbc","type":"text","conversion_output":true,"text":"OMERACT-OARSI responder criteria involve changes that are deemed to be clinically relevant","text_display":" OMERACT-OARSI responder criteria involve changes that are deemed to be clinically relevant","confidence":1,"confidence_rate":1},{"cnt":[[245,1233],[1880,1233],[1880,1285],[245,1285]],"region":{"top_left_x":244,"top_left_y":1233,"width":1636,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9736c4063fa6424a9f645b64599c4278","type":"text","conversion_output":true,"text":"in three domains: pain, function, and Patient's Global Assessment. For each of these domains,","text_display":" in three domains: pain, function, and Patient's Global Assessment. For each of these domains,","confidence":1,"confidence_rate":1},{"cnt":[[245,1285],[1880,1285],[1880,1334],[245,1334]],"region":{"top_left_x":244,"top_left_y":1284,"width":1636,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c81f337ca4e4888aebf6185652f4f4f","type":"text","conversion_output":true,"text":"ranges are defined for absolute and percent changes from baseline that correspond to \"high","text_display":" ranges are defined for absolute and percent changes from baseline that correspond to \"high","confidence":1,"confidence_rate":1},{"cnt":[[245,1332],[1880,1332],[1880,1381],[245,1381]],"region":{"top_left_x":244,"top_left_y":1332,"width":1636,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fefc376886c4ca790e096410f6071be","type":"text","conversion_output":true,"text":"improvement\" and \"moderate improvement\". OMERACT-OARSI response is defined as either","text_display":" improvement\" and \"moderate improvement\". OMERACT-OARSI response is defined as either","confidence":0.9990234375,"confidence_rate":0.9999890220866866},{"cnt":[[245,1379],[1880,1379],[1880,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1379,"width":1636,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5c4e62e2b8e4ab1b86be6359a8d43f8","type":"text","conversion_output":true,"text":"i) high improvement in pain or function or ii) moderate improvement in at least 2 of the 3","text_display":" i) high improvement in pain or function or ii) moderate improvement in at least 2 of the 3","confidence":1,"confidence_rate":1},{"cnt":[[245,1427],[1244,1427],[1244,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1426,"width":1000,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e3022ea8df5468ca8dcc818f94ce8da","type":"text","conversion_output":true,"text":"domains (pain, function, and Patient's Global Assessment).","text_display":" domains (pain, function, and Patient's Global Assessment).","confidence":1,"confidence_rate":1},{"cnt":[[245,1517],[1880,1517],[1880,1566],[245,1566]],"region":{"top_left_x":244,"top_left_y":1516,"width":1636,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fe6e2648f394b498b7435294e644822","type":"text","conversion_output":true,"text":"In this trial, OMERACT-OARSI response will be determined using WOMAC pain and function","text_display":"\n\nIn this trial, OMERACT-OARSI response will be determined using WOMAC pain and function","confidence":1,"confidence_rate":1},{"cnt":[[245,1564],[1137,1564],[1137,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1564,"width":893,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4b6da859f9643d495dcaa43c47ba620","type":"text","conversion_output":true,"text":"index scores and the PGA described in Section 7.3.3.","text_display":" index scores and the PGA described in Section 7.3.3.","confidence":1,"confidence_rate":1},{"cnt":[[241,1650],[883,1650],[883,1721],[241,1721]],"region":{"top_left_x":240,"top_left_y":1650,"width":644,"height":71},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0485003f7a3241ceb9cb8d8cad475ad8","type":"section_header","conversion_output":false,"children_ids":["0faa72cf256742a39358802a7f1d70b2","1107007b40444be9ac3ea1a271c02bfd"],"text":"","text_display":""},{"cnt":[[245,1659],[316,1659],[316,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":72,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0faa72cf256742a39358802a7f1d70b2","type":"text","conversion_output":true,"parent_id":"0485003f7a3241ceb9cb8d8cad475ad8","text":"8.4","text_display":"\n\n\\section*{8.4","confidence":1,"confidence_rate":1},{"cnt":[[593,1659],[879,1659],[879,1712],[593,1712]],"region":{"top_left_x":592,"top_left_y":1658,"width":287,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1107007b40444be9ac3ea1a271c02bfd","type":"text","conversion_output":true,"parent_id":"0485003f7a3241ceb9cb8d8cad475ad8","text":"Analysis Sets","text_display":" Analysis Sets}","confidence":1,"confidence_rate":1},{"cnt":[[241,1749],[1147,1749],[1147,1807],[241,1807]],"region":{"top_left_x":240,"top_left_y":1748,"width":908,"height":59},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bf7ed8476e04e9e80ab77ac63aef786","type":"section_header","conversion_output":false,"children_ids":["4d0c8b8d73204611840e529b377cebfd"],"text":"","text_display":""},{"cnt":[[245,1753],[1141,1753],[1141,1803],[245,1803]],"region":{"top_left_x":244,"top_left_y":1753,"width":897,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d0c8b8d73204611840e529b377cebfd","type":"text","conversion_output":true,"parent_id":"7bf7ed8476e04e9e80ab77ac63aef786","text":"Intention-to-Treat Analysis Set (Full Analysis Set)","text_display":"\n\n\\section*{Intention-to-Treat Analysis Set (Full Analysis Set)}","confidence":1,"confidence_rate":1},{"cnt":[[245,1841],[1880,1841],[1880,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1841,"width":1636,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b9313ba6ddf4fa0bef0757534756e96","type":"text","conversion_output":true,"text":"The Intention-to-Treat (ITT) Analysis Set will include all subjects randomly allocated to a","text_display":"\n\nThe Intention-to-Treat (ITT) Analysis Set will include all subjects randomly allocated to a","confidence":0.99365234375,"confidence_rate":0.9999336700303182},{"cnt":[[245,1891],[1882,1891],[1882,1940],[245,1940]],"region":{"top_left_x":244,"top_left_y":1890,"width":1639,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27461caf9a1845528d615a992d995a8a","type":"text","conversion_output":true,"text":"treatment, based on the intention to treat \"as randomized\" principle (i.e., the planned treatment","text_display":" treatment, based on the intention to treat \"as randomized\" principle (i.e., the planned treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1465,1938],[1465,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1937,"width":1222,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c79b9ae2ead48ce9de57b938e2b5039","type":"text","conversion_output":true,"text":"regimen rather than the actual treatment given in case of any difference).","text_display":" regimen rather than the actual treatment given in case of any difference).","confidence":1,"confidence_rate":1},{"cnt":[[241,2024],[986,2024],[986,2082],[241,2082]],"region":{"top_left_x":240,"top_left_y":2023,"width":747,"height":59},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90096735a52045f0ad73fbf35512c370","type":"section_header","conversion_output":false,"children_ids":["45b00a3325f84c24a0c07c21264a9b2b"],"text":"","text_display":""},{"cnt":[[245,2028],[982,2028],[982,2078],[245,2078]],"region":{"top_left_x":244,"top_left_y":2028,"width":738,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45b00a3325f84c24a0c07c21264a9b2b","type":"text","conversion_output":true,"parent_id":"90096735a52045f0ad73fbf35512c370","text":"Modified Intention-to-Treat Analysis Set","text_display":"\n\n\\section*{Modified Intention-to-Treat Analysis Set}","confidence":1,"confidence_rate":1},{"cnt":[[245,2116],[1880,2116],[1880,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2116,"width":1636,"height":52},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be0ac87f76584699aef199f0f7d87f02","type":"text","conversion_output":true,"text":"The Modified ITT (mITT) Analysis Set will include all subjects from the ITT Analysis Set who","text_display":"\n\nThe Modified ITT (mITT) Analysis Set will include all subjects from the ITT Analysis Set who","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[243,2161],[1485,2161],[1485,2215],[243,2215]],"region":{"top_left_x":242,"top_left_y":2161,"width":1243,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee3d34e0fdd346e59e351fcad5f333aa","type":"text","conversion_output":true,"text":"have a baseline and at least one post-treatment MRI assessment available.","text_display":" have a baseline and at least one post-treatment MRI assessment available.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ed6a2c13b9274c6a9302899630b5e0b1","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2546],[389,2544],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2543,"width":146,"height":44},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"08660198b0cb479bbfd18b84859d6753","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c86d994029b47c8b2b8bd6e641d8725","type":"page_info","conversion_output":false,"text":"88/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-089","page":89,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97f96c64ad5e460eb194b3affa4b2a4d","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"066a8d4110784a13b9d636921d3af6a5","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"669123b5cdc647e3bc4298e2a87b79e3","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[715,275],[715,337],[241,337]],"region":{"top_left_x":240,"top_left_y":275,"width":476,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fdb0251907944d082dc80e6f78b0a68","type":"section_header","conversion_output":false,"children_ids":["4324805e31a447a8b7ba6f99228bf928"],"text":"","text_display":""},{"cnt":[[245,279],[711,279],[711,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":468,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4324805e31a447a8b7ba6f99228bf928","type":"text","conversion_output":true,"parent_id":"0fdb0251907944d082dc80e6f78b0a68","text":"Per-Protocol Analysis Set","text_display":"\n\n\\section*{Per-Protocol Analysis Set}","confidence":0.998046875,"confidence_rate":0.9999348342955167},{"cnt":[[245,370],[1880,370],[1880,419],[245,419]],"region":{"top_left_x":244,"top_left_y":369,"width":1636,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cf66f2363b846f885277cf6457ad314","type":"text","conversion_output":true,"text":"The Per-Protocol (PP) Analysis Set will include all subjects from the mITT Analysis Set who","text_display":"\n\nThe Per-Protocol (PP) Analysis Set will include all subjects from the mITT Analysis Set who","confidence":0.9887795448303223,"confidence_rate":0.9998824664976531},{"cnt":[[245,417],[1734,417],[1734,468],[245,468]],"region":{"top_left_x":244,"top_left_y":416,"width":1490,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6880ec60d3f642e7b924108f3a078b13","type":"text","conversion_output":true,"text":"have been treated according to the clinical trial protocol and fulfill the following criteria:","text_display":" have been treated according to the clinical trial protocol and fulfill the following criteria:","confidence":1,"confidence_rate":1},{"cnt":[[245,490],[868,490],[868,541],[245,541]],"region":{"top_left_x":244,"top_left_y":489,"width":624,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59b4037a8fa344d7aec5d0acabac11eb","type":"text","conversion_output":true,"text":"- Compliance with all entry criteria","text_display":"\n- Compliance with all entry criteria","confidence":1,"confidence_rate":1},{"cnt":[[245,561],[1880,561],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":560,"width":1636,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9dde5d4a53c43faa4e22209db720505","type":"text","conversion_output":true,"text":"- Absence of major clinical trial protocol violations with respect to factors likely to affect the","text_display":"\n- Absence of major clinical trial protocol violations with respect to factors likely to affect the","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[292,610],[1882,610],[1882,660],[292,660]],"region":{"top_left_x":292,"top_left_y":610,"width":1591,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5fa9a0ef9974a90825e1cba838ea75d","type":"text","conversion_output":true,"text":"efficacy of treatment, where the nature of such clinical trial protocol violations will be defined","text_display":" efficacy of treatment, where the nature of such clinical trial protocol violations will be defined","confidence":0.9990234375,"confidence_rate":0.9999905142231666},{"cnt":[[292,657],[726,657],[726,707],[292,707]],"region":{"top_left_x":292,"top_left_y":657,"width":435,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bb00786275e4ffaaf1babd02e80cf5e","type":"text","conversion_output":true,"text":"before breaking the blind","text_display":" before breaking the blind","confidence":1,"confidence_rate":1},{"cnt":[[245,726],[1575,726],[1575,780],[245,780]],"region":{"top_left_x":244,"top_left_y":726,"width":1331,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c42343420be1473996f227893acffa7a","type":"text","conversion_output":true,"text":"- Adequate compliance with trial medication (this will be defined in the SAP)","text_display":"\n- Adequate compliance with trial medication (this will be defined in the SAP)","confidence":1,"confidence_rate":1},{"cnt":[[241,816],[599,816],[599,874],[241,874]],"region":{"top_left_x":240,"top_left_y":816,"width":360,"height":59},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5114353d6c9e4b82b7698ea93c36e521","type":"section_header","conversion_output":false,"children_ids":["122b4f721533458f8440530c539f34e4"],"text":"","text_display":""},{"cnt":[[245,821],[595,821],[595,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":352,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"122b4f721533458f8440530c539f34e4","type":"text","conversion_output":true,"parent_id":"5114353d6c9e4b82b7698ea93c36e521","text":"Safety Analysis Set","text_display":"\n\n\\section*{Safety Analysis Set}","confidence":1,"confidence_rate":1},{"cnt":[[245,907],[1880,907],[1880,958],[245,958]],"region":{"top_left_x":244,"top_left_y":906,"width":1636,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1b90a05321b4b489cd23b2f12b09b60","type":"text","conversion_output":true,"text":"The Safety Analysis Set will include all subjects who receive at least one dose of trial treatment.","text_display":"\n\nThe Safety Analysis Set will include all subjects who receive at least one dose of trial treatment.","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,956],[1459,956],[1459,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":956,"width":1215,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57188105149a444498cf45c28b10f2e6","type":"text","conversion_output":true,"text":"Subjects will be analyzed according to the actual treatment they receive.","text_display":" Subjects will be analyzed according to the actual treatment they receive.","confidence":0.9990234375,"confidence_rate":0.9999874739291208},{"cnt":[[241,1040],[793,1040],[793,1102],[241,1102]],"region":{"top_left_x":240,"top_left_y":1039,"width":553,"height":64},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc60a59710534ff0b18d318beaefee30","type":"section_header","conversion_output":false,"children_ids":["18cf34ef201b49c1869d4155fbc86e8b"],"text":"","text_display":""},{"cnt":[[245,1048],[786,1048],[786,1098],[245,1098]],"region":{"top_left_x":244,"top_left_y":1048,"width":543,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18cf34ef201b49c1869d4155fbc86e8b","type":"text","conversion_output":true,"parent_id":"dc60a59710534ff0b18d318beaefee30","text":"Pharmacokinetic Analysis Set","text_display":"\n\n\\section*{Pharmacokinetic Analysis Set}","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[1880,1134],[1880,1188],[245,1188]],"region":{"top_left_x":244,"top_left_y":1134,"width":1636,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18396e8fc04f4768baea9a44d87ab44e","type":"text","conversion_output":true,"text":"The PK Analysis Set will include all subjects from the Safety Analysis Set with at least one","text_display":"\n\nThe PK Analysis Set will include all subjects from the Safety Analysis Set with at least one","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,1182],[1046,1182],[1046,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1181,"width":803,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2739b8a374b2480680ba177211dbad6e","type":"text","conversion_output":true,"text":"available serum or synovial fluid measurement.","text_display":" available serum or synovial fluid measurement.","confidence":1,"confidence_rate":1},{"cnt":[[241,1268],[604,1268],[604,1330],[241,1330]],"region":{"top_left_x":240,"top_left_y":1267,"width":364,"height":63},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75ee5de6065245528a3a50de0cfb0ef6","type":"section_header","conversion_output":false,"children_ids":["10b4da5e36504883828aaf45fc81ba8a"],"text":"","text_display":""},{"cnt":[[245,1276],[597,1276],[597,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1276,"width":354,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10b4da5e36504883828aaf45fc81ba8a","type":"text","conversion_output":true,"parent_id":"75ee5de6065245528a3a50de0cfb0ef6","text":"Subgroup Analyses","text_display":"\n\n\\section*{Subgroup Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[245,1362],[1882,1362],[1882,1414],[245,1414]],"region":{"top_left_x":244,"top_left_y":1362,"width":1639,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98fdaa02a1ec44978ca10d53fe28f202","type":"text","conversion_output":true,"text":"Subgroup analyses (especially for the analysis of the primary endpoint) will be considered for","text_display":"\n\nSubgroup analyses (especially for the analysis of the primary endpoint) will be considered for","confidence":1,"confidence_rate":1},{"cnt":[[245,1409],[1880,1409],[1880,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1409,"width":1636,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4d24bfff540405cbb4c520eb9cbbc58","type":"text","conversion_output":true,"text":"categories including Kellgren-Lawrence grade (Grade 2, Grade 3), sex (Male, Female), age","text_display":" categories including Kellgren-Lawrence grade (Grade 2, Grade 3), sex (Male, Female), age","confidence":1,"confidence_rate":1},{"cnt":[[245,1452],[1837,1452],[1837,1510],[245,1510]],"region":{"top_left_x":244,"top_left_y":1452,"width":1593,"height":59},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2986e9fb34494cd7a003f7e35c1a53e4","type":"text","conversion_output":true,"text":"( \\(<65\\) years old, \\(\\geq 65\\) years old), body mass index (BMI; \\(<30 kg / m ^{2}, \\geq 30 kg / m ^{2}\\) ), and country.","text_display":" ( \\(<65\\) years old, \\(\\geq 65\\) years old), body mass index (BMI; \\(<30 kg / m ^{2}, \\geq 30 kg / m ^{2}\\) ), and country.","confidence":0.9990236759185791,"confidence_rate":0.999992368771335},{"cnt":[[236,1543],[1317,1543],[1317,1613],[236,1613]],"region":{"top_left_x":236,"top_left_y":1542,"width":1081,"height":72},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"232472472b1c4e8dbc32932ec7918e58","type":"section_header","conversion_output":false,"children_ids":["088488179d914d19aaaaced6e4952ef3"],"text":"","text_display":""},{"cnt":[[245,1551],[1313,1551],[1313,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1551,"width":1069,"height":59},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"088488179d914d19aaaaced6e4952ef3","type":"text","conversion_output":true,"parent_id":"232472472b1c4e8dbc32932ec7918e58","text":"8.5 Description of Statistical Analyses","text_display":"\n\n\\subsection*{8.5 Description of Statistical Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[241,1641],[1102,1641],[1102,1704],[241,1704]],"region":{"top_left_x":240,"top_left_y":1641,"width":863,"height":63},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2a49c38068144f49e1e96998936252b","type":"section_header","conversion_output":false,"children_ids":["62cc16eb75824ec69b7e1f0e42d8bc81"],"text":"","text_display":""},{"cnt":[[245,1650],[1098,1650],[1098,1699],[245,1699]],"region":{"top_left_x":244,"top_left_y":1650,"width":854,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62cc16eb75824ec69b7e1f0e42d8bc81","type":"text","conversion_output":true,"parent_id":"e2a49c38068144f49e1e96998936252b","text":"8.5.1 General Considerations","text_display":"\n\n\\subsection*{8.5.1 General Considerations}","confidence":0.9965834617614746,"confidence_rate":0.9998962966523246},{"cnt":[[245,1745],[1880,1745],[1880,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1744,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af7fa229cf8e49439adc9b5538d995e7","type":"text","conversion_output":true,"text":"An outline of the analysis currently planned is presented in the following sections. The full","text_display":"\n\nAn outline of the analysis currently planned is presented in the following sections. The full","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1880,1792],[1880,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1636,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ca0b11f0f8f484aa20b4a05f99ad207","type":"text","conversion_output":true,"text":"documentation will be provided in the Statistical Analysis Plan (SAP), which will be finalized","text_display":" documentation will be provided in the Statistical Analysis Plan (SAP), which will be finalized","confidence":1,"confidence_rate":1},{"cnt":[[245,1839],[868,1839],[868,1888],[245,1888]],"region":{"top_left_x":244,"top_left_y":1839,"width":624,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fce48dbdc22b4ef0b246553d06579396","type":"text","conversion_output":true,"text":"before database lock and unblinding.","text_display":" before database lock and unblinding.","confidence":1,"confidence_rate":1},{"cnt":[[245,1929],[1880,1929],[1880,1979],[245,1979]],"region":{"top_left_x":244,"top_left_y":1929,"width":1636,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6948c38f42048eb949c727f9a353c7f","type":"text","conversion_output":true,"text":"It is planned to perform the statistical analysis in two steps. Approximately three months after the","text_display":"\n\nIt is planned to perform the statistical analysis in two steps. Approximately three months after the","confidence":1,"confidence_rate":1},{"cnt":[[245,1977],[1882,1977],[1882,2026],[245,2026]],"region":{"top_left_x":244,"top_left_y":1976,"width":1639,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09e842f8681b43fbb119501dd3870e05","type":"text","conversion_output":true,"text":"last subject's last visit of the DBPC treatment phase, the database will be locked, the treatment","text_display":" last subject's last visit of the DBPC treatment phase, the database will be locked, the treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,2024],[1880,2024],[1880,2075],[245,2075]],"region":{"top_left_x":244,"top_left_y":2023,"width":1636,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae8fab2952b74352a5e5684b4ee051c0","type":"text","conversion_output":true,"text":"code will be unblinded, complete analyses will be performed, and a detailed Clinical Trial Report","text_display":" code will be unblinded, complete analyses will be performed, and a detailed Clinical Trial Report","confidence":1,"confidence_rate":1},{"cnt":[[245,2071],[1880,2071],[1880,2125],[245,2125]],"region":{"top_left_x":244,"top_left_y":2071,"width":1636,"height":54},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cefbdc55fdf400a99a2eea27d60702b","type":"text","conversion_output":true,"text":"will be written based on the data collected up to the end of the DBPC treatment phase. Long-","text_display":" will be written based on the data collected up to the end of the DBPC treatment phase. Long","confidence":1,"confidence_rate":1},{"cnt":[[245,2123],[1880,2123],[1880,2172],[245,2172]],"region":{"top_left_x":244,"top_left_y":2122,"width":1636,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e085f2476d6b4979b0fcf5a38b026eb9","type":"text","conversion_output":true,"text":"term follow-up data will be analyzed and reported separately from the DBPC treatment phase","text_display":"term follow-up data will be analyzed and reported separately from the DBPC treatment phase","confidence":1,"confidence_rate":1},{"cnt":[[245,2168],[1880,2168],[1880,2219],[245,2219]],"region":{"top_left_x":244,"top_left_y":2167,"width":1636,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8a94f982cf24926801979cd9afa9b43","type":"text","conversion_output":true,"text":"results. MRI readers, Investigators, and subjects will remain blinded during the extended follow-","text_display":" results. MRI readers, Investigators, and subjects will remain blinded during the extended follow","confidence":1,"confidence_rate":1},{"cnt":[[245,2217],[410,2217],[410,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2217,"width":167,"height":54},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bb51a5f000241ae9854eda64ea28817","type":"text","conversion_output":true,"text":"up phase.","text_display":"up phase.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"87932924ac934aedb6e420fca89c4aaf","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"16b1941a7f6a47808693302a113ba921","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2eaec944ba94990865e3f71e55e688d","type":"page_info","conversion_output":false,"text":"89/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-090","page":90,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ec043eb8c88416498a780be0595941d","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbf325666e4e435aa5c4e65ea79841bb","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba45b7a10b4341628d257702b7092914","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,275],[604,275],[604,337],[241,337]],"region":{"top_left_x":240,"top_left_y":275,"width":364,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31fb4cd0cdd244adaf046b3394238b67","type":"section_header","conversion_output":false,"children_ids":["b2c873eb8bc942bfb0a34a58eb30b6b6"],"text":"","text_display":""},{"cnt":[[245,279],[599,279],[599,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":356,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2c873eb8bc942bfb0a34a58eb30b6b6","type":"text","conversion_output":true,"parent_id":"31fb4cd0cdd244adaf046b3394238b67","text":"Summary Statistics","text_display":"\n\n\\section*{Summary Statistics}","confidence":1,"confidence_rate":1},{"cnt":[[245,370],[1880,370],[1880,419],[245,419]],"region":{"top_left_x":244,"top_left_y":369,"width":1636,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"523c91f109a24524baed10512cee03ab","type":"text","conversion_output":true,"text":"The summary statistics presented for quantitative variables will be the number of observations","text_display":"\n\nThe summary statistics presented for quantitative variables will be the number of observations","confidence":0.9975600242614746,"confidence_rate":0.9999753239677883},{"cnt":[[245,417],[1880,417],[1880,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57d96c5c535d471db54135ddda61f3fa","type":"text","conversion_output":true,"text":"(n), the number of missing values (missing), mean, standard deviation (SD), median, first and","text_display":" (n), the number of missing values (missing), mean, standard deviation (SD), median, first and","confidence":1,"confidence_rate":1},{"cnt":[[245,466],[1491,466],[1491,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1248,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06963493fcb6426e8c7db1af35244693","type":"text","conversion_output":true,"text":"third quartiles (Q1, Q3), and minimum (min) and maximum (max) values.","text_display":" third quartiles (Q1, Q3), and minimum (min) and maximum (max) values.","confidence":0.9970703125,"confidence_rate":0.9999603523071421},{"cnt":[[245,554],[1882,554],[1882,608],[245,608]],"region":{"top_left_x":244,"top_left_y":554,"width":1639,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18c12221b7f74a559e97b1dad4279b4a","type":"text","conversion_output":true,"text":"The summary statistics presented for categorical data will be the number of observations ( n ), the","text_display":"\n\nThe summary statistics presented for categorical data will be the number of observations ( n ), the","confidence":0.6765480400063097,"confidence_rate":0.9964540126305831},{"cnt":[[245,604],[1841,604],[1841,655],[245,655]],"region":{"top_left_x":244,"top_left_y":603,"width":1598,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cbd0dfa736f4f59a44263299dfdf1cd","type":"text","conversion_output":true,"text":"number of missing values (missing), and the count and percentage of subjects in each category.","text_display":" number of missing values (missing), and the count and percentage of subjects in each category.","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[241,690],[754,690],[754,750],[241,750]],"region":{"top_left_x":240,"top_left_y":689,"width":515,"height":61},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ead1aa329f6448cfa7ceec4fe46cef1a","type":"section_header","conversion_output":false,"children_ids":["a4403e8289bc4e69b6bc368b585b1bb8"],"text":"","text_display":""},{"cnt":[[245,696],[750,696],[750,746],[245,746]],"region":{"top_left_x":244,"top_left_y":696,"width":506,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4403e8289bc4e69b6bc368b585b1bb8","type":"text","conversion_output":true,"parent_id":"ead1aa329f6448cfa7ceec4fe46cef1a","text":"Adjustment for Multiplicity","text_display":"\n\n\\section*{Adjustment for Multiplicity}","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1880,782],[1880,834],[245,834]],"region":{"top_left_x":244,"top_left_y":782,"width":1636,"height":52},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4263c7d2345c48cb91312182e5a43306","type":"text","conversion_output":true,"text":"The main objective of this Phase II trial is to select a dose regimen for further development in","text_display":"\n\nThe main objective of this Phase II trial is to select a dose regimen for further development in","confidence":1,"confidence_rate":1},{"cnt":[[245,829],[1880,829],[1880,883],[245,883]],"region":{"top_left_x":244,"top_left_y":829,"width":1636,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e02478caf724209b5852d02e46dde00","type":"text","conversion_output":true,"text":"Phase III; therefore, no adjustment for multiplicity will be made. Caution should be used in","text_display":" Phase III; therefore, no adjustment for multiplicity will be made. Caution should be used in","confidence":1,"confidence_rate":1},{"cnt":[[245,879],[1880,879],[1880,930],[245,930]],"region":{"top_left_x":244,"top_left_y":878,"width":1636,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d511054307034f36b7a58175f848fd44","type":"text","conversion_output":true,"text":"interpreting significant p -values ( \\(p <0.05\\) ). Interpretation of the results will involve global","text_display":" interpreting significant p -values ( \\(p <0.05\\) ). Interpretation of the results will involve global","confidence":0.982446182055412,"confidence_rate":0.9998432891541184},{"cnt":[[245,924],[1884,924],[1884,978],[245,978]],"region":{"top_left_x":244,"top_left_y":923,"width":1641,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9361dafc9ac4bee99d32f1023b04a2c","type":"text","conversion_output":true,"text":"consideration of all efficacy results obtained in combination with an appropriate judgment of","text_display":" consideration of all efficacy results obtained in combination with an appropriate judgment of","confidence":0.9956073760986328,"confidence_rate":0.9999550795822252},{"cnt":[[245,971],[597,971],[597,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":971,"width":354,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7467410b6d1d407da5725dd355d1db3e","type":"text","conversion_output":true,"text":"clinical significance.","text_display":" clinical significance.","confidence":0.9721813201904297,"confidence_rate":0.9989556217240009},{"cnt":[[241,1059],[494,1059],[494,1119],[241,1119]],"region":{"top_left_x":240,"top_left_y":1059,"width":255,"height":61},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd3e71fea2cf47c1a78833f711506f0b","type":"section_header","conversion_output":false,"children_ids":["caf9b4f05fce42a9a2b5e71f26d76327"],"text":"","text_display":""},{"cnt":[[245,1066],[488,1066],[488,1115],[245,1115]],"region":{"top_left_x":244,"top_left_y":1065,"width":244,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"caf9b4f05fce42a9a2b5e71f26d76327","type":"text","conversion_output":true,"parent_id":"dd3e71fea2cf47c1a78833f711506f0b","text":"Missing Data","text_display":"\n\n\\section*{Missing Data}","confidence":1,"confidence_rate":1},{"cnt":[[245,1152],[1884,1152],[1884,1205],[245,1205]],"region":{"top_left_x":244,"top_left_y":1151,"width":1641,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c978f0bf2e44ca6a5e24c6cde750780","type":"text","conversion_output":true,"text":"As a general rule, all data collected and available will be used in the analysis. No imputation of","text_display":"\n\nAs a general rule, all data collected and available will be used in the analysis. No imputation of","confidence":1,"confidence_rate":1},{"cnt":[[245,1199],[1796,1199],[1796,1253],[245,1253]],"region":{"top_left_x":244,"top_left_y":1198,"width":1553,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2174b6d826b489f93d08fd93d41f7b3","type":"text","conversion_output":true,"text":"missing data will be applied independently of the statistical method used to analyze the data.","text_display":" missing data will be applied independently of the statistical method used to analyze the data.","confidence":1,"confidence_rate":1},{"cnt":[[245,1291],[1880,1291],[1880,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1291,"width":1636,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8cbea3ff69c4adf8a7229a6ebcd739c","type":"text","conversion_output":true,"text":"Handling of missing data from questionnaires will depend on whether only single items are","text_display":"\n\nHandling of missing data from questionnaires will depend on whether only single items are","confidence":1,"confidence_rate":1},{"cnt":[[245,1336],[1880,1336],[1880,1390],[245,1390]],"region":{"top_left_x":244,"top_left_y":1336,"width":1636,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c26b497c073f408cb0680f9309aa1524","type":"text","conversion_output":true,"text":"missing or a complete questionnaire is missing. If only single items are missing, the rules defined","text_display":" missing or a complete questionnaire is missing. If only single items are missing, the rules defined","confidence":0.9990234375,"confidence_rate":0.9999906054321309},{"cnt":[[245,1386],[1880,1386],[1880,1437],[245,1437]],"region":{"top_left_x":244,"top_left_y":1385,"width":1636,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10adea267bf44b8880e313dfb7eddc0d","type":"text","conversion_output":true,"text":"by the authors of the questionnaires (if any) will be followed. If a complete questionnaire is","text_display":" by the authors of the questionnaires (if any) will be followed. If a complete questionnaire is","confidence":1,"confidence_rate":1},{"cnt":[[245,1435],[1880,1435],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1435,"width":1636,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c3be8d5c90a4fef820c4269a2d0b58e","type":"text","conversion_output":true,"text":"missing, different methods of imputation will be used and results will be compared in a","text_display":" missing, different methods of imputation will be used and results will be compared in a","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[578,1482],[578,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1482,"width":334,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"904498c8789e4784b9f28495aed83893","type":"text","conversion_output":true,"text":"sensitivity analysis.","text_display":" sensitivity analysis.","confidence":1,"confidence_rate":1},{"cnt":[[241,1568],[1235,1568],[1235,1639],[241,1639]],"region":{"top_left_x":240,"top_left_y":1568,"width":996,"height":72},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80f1ea7123924fb58c22b8431300df85","type":"section_header","conversion_output":false,"children_ids":["44401bdf272643e7925dc8dbddb2da2d"],"text":"","text_display":""},{"cnt":[[245,1573],[1227,1573],[1227,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1572,"width":983,"height":63},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44401bdf272643e7925dc8dbddb2da2d","type":"text","conversion_output":true,"parent_id":"80f1ea7123924fb58c22b8431300df85","text":"8.5.2 Analysis of Primary Endpoint","text_display":"\n\n\\subsection*{8.5.2 Analysis of Primary Endpoint}","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[1880,1667],[1880,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1667,"width":1636,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f16d8c0856f47628932edfce579644c","type":"text","conversion_output":true,"text":"The primary endpoint is the change from baseline in cartilage thickness in the total femorotibial","text_display":"\n\nThe primary endpoint is the change from baseline in cartilage thickness in the total femorotibial","confidence":1,"confidence_rate":1},{"cnt":[[243,1714],[866,1714],[866,1768],[243,1768]],"region":{"top_left_x":242,"top_left_y":1714,"width":624,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a93ee3d08e824f2aa10f938626af0f2a","type":"text","conversion_output":true,"text":"joint as evaluated by MRI at 2 years.","text_display":" joint as evaluated by MRI at 2 years.","confidence":1,"confidence_rate":1},{"cnt":[[245,1807],[1880,1807],[1880,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1806,"width":1636,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34c889a40fa24f3fab8a568fe635adcf","type":"text","conversion_output":true,"text":"The cartilage thickness in the total femorotibial joint as evaluated by MRI will be tabulated per","text_display":"\n\nThe cartilage thickness in the total femorotibial joint as evaluated by MRI will be tabulated per","confidence":1,"confidence_rate":1},{"cnt":[[245,1856],[1880,1856],[1880,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1856,"width":1636,"height":54},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c70de20a266e4447b88762c431eec07f","type":"text","conversion_output":true,"text":"time point (visit) and treatment group, along with the absolute change from baseline and the","text_display":" time point (visit) and treatment group, along with the absolute change from baseline and the","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[754,1904],[754,1955],[245,1955]],"region":{"top_left_x":244,"top_left_y":1903,"width":511,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c1e69c47af14b60a79552d6cd306043","type":"text","conversion_output":true,"text":"percent change from baseline.","text_display":" percent change from baseline.","confidence":1,"confidence_rate":1},{"cnt":[[245,1989],[1880,1989],[1880,2043],[245,2043]],"region":{"top_left_x":244,"top_left_y":1989,"width":1636,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6417975ea99b45be8b82bf3e3ef86b62","type":"text","conversion_output":true,"text":"The treatment effect on the primary endpoint will be assessed through dose-ranging using a","text_display":"\n\nThe treatment effect on the primary endpoint will be assessed through dose-ranging using a","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1880,2041],[1880,2090],[245,2090]],"region":{"top_left_x":244,"top_left_y":2041,"width":1636,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"532a673163504431846c18dda5e91496","type":"text","conversion_output":true,"text":"repeated measurement analysis of variance (ANOVA, using PROC MIXED in SAS) on absolute","text_display":" repeated measurement analysis of variance (ANOVA, using PROC MIXED in SAS) on absolute","confidence":1,"confidence_rate":1},{"cnt":[[245,2088],[1880,2088],[1880,2140],[245,2140]],"region":{"top_left_x":244,"top_left_y":2088,"width":1636,"height":52},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f96cbe913814afeb115cefcdb9d5605","type":"text","conversion_output":true,"text":"change from baseline, including the baseline value, the treatment group, the time, and the","text_display":" change from baseline, including the baseline value, the treatment group, the time, and the","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[1336,2136],[1336,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2135,"width":1093,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"357e0eadebc543a18cd3a7726209eaa1","type":"text","conversion_output":true,"text":"country as factors and including treatment by time as interaction.","text_display":" country as factors and including treatment by time as interaction.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"222f09adb2d7452e9da774b4844a8118","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2547],[389,2545],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":43},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d682bca04dd6471c8eb4ef6ed44b84ea","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9d7477bd0bf4a4bbca580671e32985e","type":"page_info","conversion_output":false,"text":"90/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-091","page":91,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ed60c60f0be4c2fbf491a1f844e5363","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53c08ec27242426c9158e7cc2fc76ba7","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"535b93e3eba849a68cd225a75c9e1a52","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,333],[245,333]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ff61aeed93f42ed9ff0603961cc04fe","type":"text","conversion_output":true,"text":"The primary efficacy analysis will consist of testing the linear dose relationship and the overall","text_display":"\n\nThe primary efficacy analysis will consist of testing the linear dose relationship and the overall","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1777,329],[1777,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1533,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0902b5dba6b34e6f852e50f30e6e2f0f","type":"text","conversion_output":true,"text":"treatment effect at 2 years. The significance level will be set at \\(5 \\%\\) two-sided for both tests.","text_display":" treatment effect at 2 years. The significance level will be set at \\(5 \\%\\) two-sided for both tests.","confidence":0.992205130870218,"confidence_rate":0.9999261781219224},{"cnt":[[245,417],[1629,417],[1629,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1385,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a301cf42e9542db9d3412a6090a74b8","type":"text","conversion_output":true,"text":"For the linear dose relationship testing, the null and alternative hypotheses will be:","text_display":"\n\nFor the linear dose relationship testing, the null and alternative hypotheses will be:","confidence":1,"confidence_rate":1},{"cnt":[[243,505],[1854,505],[1854,563],[243,563]],"region":{"top_left_x":242,"top_left_y":504,"width":1613,"height":59},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a0235ed5db5404fb0206d0cc7e2663c","type":"text","conversion_output":true,"text":"\\(H_{0}:-2\\) Mean \\(_{\\left(\\text {Placebo }^{\\circ}\\right)}-1\\) Mean \\(_{(180 mcg )}+0\\) Mean \\(_{(360 mcg )}+1\\) Mean \\(_{(600 mcg )}+2\\) Mean \\(_{(1200 mcg )}=0\\)","text_display":"\n\\(H_{0}:-2\\) Mean \\(_{\\left(\\text {Placebo }^{\\circ}\\right)}-1\\) Mean \\(_{(180 mcg )}+0\\) Mean \\(_{(360 mcg )}+1\\) Mean \\(_{(600 mcg )}+2\\) Mean \\(_{(1200 mcg )}=0\\)","confidence":0.5850899721239016,"confidence_rate":0.9968334876473842},{"cnt":[[243,597],[1846,597],[1846,655],[243,655]],"region":{"top_left_x":242,"top_left_y":597,"width":1604,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcab4e246928457c9486a41746bf2558","type":"text","conversion_output":true,"text":"\\(H_{1}:-2\\) Mean \\(_{\\left(\\text {Placebo }^{-}\\right)}-1\\) Mean \\(_{\\left(180 \\text { mcg }^{-}\\right)}+0\\) Mean \\(_{(360 mcg )}+1\\) Mean \\(_{(600 mcg )}+2\\) Mean \\(_{(1200 mcg )} \\neq 0\\)","text_display":"\n\\(H_{1}:-2\\) Mean \\(_{\\left(\\text {Placebo }^{-}\\right)}-1\\) Mean \\(_{\\left(180 \\text { mcg }^{-}\\right)}+0\\) Mean \\(_{(360 mcg )}+1\\) Mean \\(_{(600 mcg )}+2\\) Mean \\(_{(1200 mcg )} \\neq 0\\)","confidence":0.03321182258959034,"confidence_rate":0.9812619517797783},{"cnt":[[243,688],[1880,688],[1880,741],[243,741]],"region":{"top_left_x":242,"top_left_y":687,"width":1638,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1b3ddcaf9034f33bc4f583cc31268da","type":"text","conversion_output":true,"text":"where the doses shown are the total doses of sprifermin to be administered over the DBPC","text_display":"\nwhere the doses shown are the total doses of sprifermin to be administered over the DBPC","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[754,739],[754,788],[245,788]],"region":{"top_left_x":244,"top_left_y":739,"width":511,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70767656818c4300b1cb00ec79ca6e83","type":"text","conversion_output":true,"text":"treatment phase (see Table 1).","text_display":" treatment phase (see Table 1).","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1880,825],[1880,879],[245,879]],"region":{"top_left_x":244,"top_left_y":825,"width":1636,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8d680de1f094040b1f490dae7d3954c","type":"text","conversion_output":true,"text":"If the null hypothesis is rejected, the alternative hypothesis will be accepted and it will be","text_display":"\n\nIf the null hypothesis is rejected, the alternative hypothesis will be accepted and it will be","confidence":1,"confidence_rate":1},{"cnt":[[245,877],[1390,877],[1390,926],[245,926]],"region":{"top_left_x":244,"top_left_y":876,"width":1147,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"569c3b0539354d17934a7ca106dc53a8","type":"text","conversion_output":true,"text":"concluded that there is a dose relationship versus placebo over time.","text_display":" concluded that there is a dose relationship versus placebo over time.","confidence":1,"confidence_rate":1},{"cnt":[[245,965],[1629,965],[1629,1016],[245,1016]],"region":{"top_left_x":244,"top_left_y":964,"width":1385,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3acac9d7341449d5bfbb26297d236683","type":"text","conversion_output":true,"text":"For the overall treatment effect testing, the null and alternative hypotheses will be:","text_display":"\n\nFor the overall treatment effect testing, the null and alternative hypotheses will be:","confidence":1,"confidence_rate":1},{"cnt":[[243,1053],[1622,1053],[1622,1109],[243,1109]],"region":{"top_left_x":242,"top_left_y":1052,"width":1381,"height":57},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7029bb6e2ea64234ab40934e8a1974e9","type":"text","conversion_output":true,"text":"\\(H_{0}:\\) Mean \\(_{\\left(\\text {Placebo }^{\\circ}\\right)}=\\) Mean \\(_{(180 mcg )}=\\) Mean \\(_{(360 mcg )}=\\) Mean \\(_{(600 mcg )}=\\) Mean \\(_{(1200 mcg )}\\)","text_display":"\n\\(H_{0}:\\) Mean \\(_{\\left(\\text {Placebo }^{\\circ}\\right)}=\\) Mean \\(_{(180 mcg )}=\\) Mean \\(_{(360 mcg )}=\\) Mean \\(_{(600 mcg )}=\\) Mean \\(_{(1200 mcg )}\\)","confidence":0.34513564690248666,"confidence_rate":0.9934142182221319},{"cnt":[[245,1147],[1884,1147],[1884,1199],[245,1199]],"region":{"top_left_x":244,"top_left_y":1147,"width":1641,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6685ef31975e4b3c80e4e7bad1c227ed","type":"text","conversion_output":true,"text":"\\(H_{1}\\) : Mean (i) \\(\\neq\\) Mean ( \\(j\\) ) for some \\(i \\neq j\\) and \\(i, j=\\) Placebo or 180 mcg or 360 mcg or 600 mcg or","text_display":"\n\\(H_{1}\\) : Mean (i) \\(\\neq\\) Mean ( \\(j\\) ) for some \\(i \\neq j\\) and \\(i, j=\\) Placebo or 180 mcg or 360 mcg or 600 mcg or","confidence":0.2836951776375957,"confidence_rate":0.9900509736003513},{"cnt":[[245,1195],[423,1195],[423,1246],[245,1246]],"region":{"top_left_x":244,"top_left_y":1194,"width":180,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8126bfb81364e50a5457a5340529284","type":"text","conversion_output":true,"text":"1200 mcg .","text_display":" 1200 mcg .","confidence":0.506828784942627,"confidence_rate":0.958415501719877},{"cnt":[[245,1285],[1880,1285],[1880,1334],[245,1334]],"region":{"top_left_x":244,"top_left_y":1284,"width":1636,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fddfa39457974ea79b37a7e07aaeeed4","type":"text","conversion_output":true,"text":"where the doses shown are the total doses of sprifermin to be administered over the DBPC","text_display":"\nwhere the doses shown are the total doses of sprifermin to be administered over the DBPC","confidence":0.9990236759185791,"confidence_rate":0.9999894968186404},{"cnt":[[245,1332],[754,1332],[754,1381],[245,1381]],"region":{"top_left_x":244,"top_left_y":1332,"width":511,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"764b5cc34c164c1ea981992bb8c06658","type":"text","conversion_output":true,"text":"treatment phase (see Table 1).","text_display":" treatment phase (see Table 1).","confidence":1,"confidence_rate":1},{"cnt":[[245,1422],[1880,1422],[1880,1472],[245,1472]],"region":{"top_left_x":244,"top_left_y":1422,"width":1636,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59121f96bb7743dd892de13fbd8cb28a","type":"text","conversion_output":true,"text":"If the null hypothesis is rejected, the alternative hypothesis will be accepted and it will be","text_display":"\n\nIf the null hypothesis is rejected, the alternative hypothesis will be accepted and it will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1470],[1510,1470],[1510,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1469,"width":1267,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd7f9164a73b430ab080d53bded1a52b","type":"text","conversion_output":true,"text":"concluded that there is at least one group that differs from the other groups.","text_display":" concluded that there is at least one group that differs from the other groups.","confidence":1,"confidence_rate":1},{"cnt":[[245,1560],[1880,1560],[1880,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1559,"width":1636,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f11a392774c4b5c9a14eddbf0453e33","type":"text","conversion_output":true,"text":"Pairwise comparisons (sprifermin versus placebo, and between sprifermin dose and regimen","text_display":"\n\nPairwise comparisons (sprifermin versus placebo, and between sprifermin dose and regimen","confidence":1,"confidence_rate":1},{"cnt":[[245,1607],[1880,1607],[1880,1659],[245,1659]],"region":{"top_left_x":244,"top_left_y":1607,"width":1636,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6536767938b4d9caa04af1bcb524040","type":"text","conversion_output":true,"text":"groups) will be performed within the context of this modeling framework. For each pairwise","text_display":" groups) will be performed within the context of this modeling framework. For each pairwise","confidence":1,"confidence_rate":1},{"cnt":[[245,1654],[1880,1654],[1880,1706],[245,1706]],"region":{"top_left_x":244,"top_left_y":1654,"width":1636,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e715fc2ef1d74a6599180e66aa07dfc9","type":"text","conversion_output":true,"text":"comparison, the difference between treatments and the corresponding \\(95 \\%\\) confidence interval","text_display":" comparison, the difference between treatments and the corresponding \\(95 \\%\\) confidence interval","confidence":0.99462890625,"confidence_rate":0.9999456017833478},{"cnt":[[245,1704],[834,1704],[834,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1703,"width":590,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"859bd6b9c9ad4b22a5a32b7354a0b17a","type":"text","conversion_output":true,"text":"(CI) and p -value will be presented.","text_display":" (CI) and p -value will be presented.","confidence":0.9951221942901611,"confidence_rate":0.9998959683684304},{"cnt":[[245,1792],[1510,1792],[1510,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1791,"width":1267,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d9e791704644e4f9b57a5b97e8948d3","type":"text","conversion_output":true,"text":"The primary efficacy analysis will be performed on the mITT Analysis Set.","text_display":"\n\nThe primary efficacy analysis will be performed on the mITT Analysis Set.","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1880,1882],[1880,1931],[245,1931]],"region":{"top_left_x":244,"top_left_y":1882,"width":1636,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9895209101bd45deb7559edc72a35eeb","type":"text","conversion_output":true,"text":"In order to assess the robustness of the primary results, sensitivity analyses will be performed","text_display":"\nIn order to assess the robustness of the primary results, sensitivity analyses will be performed","confidence":1,"confidence_rate":1},{"cnt":[[245,1929],[1880,1929],[1880,1981],[245,1981]],"region":{"top_left_x":244,"top_left_y":1929,"width":1636,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e5147128c8a414981b1ef7819127cff","type":"text","conversion_output":true,"text":"with modification of subject population (PP Analysis Set), statistical methods (influence of the","text_display":" with modification of subject population (PP Analysis Set), statistical methods (influence of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1979],[1592,1979],[1592,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1978,"width":1348,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6710dc86a758474f9e5f13401a482864","type":"text","conversion_output":true,"text":"distribution, influence of the time effect, and so on), and influence of covariates.","text_display":" distribution, influence of the time effect, and so on), and influence of covariates.","confidence":1,"confidence_rate":1},{"cnt":[[241,2067],[1296,2067],[1296,2133],[241,2133]],"region":{"top_left_x":240,"top_left_y":2066,"width":1056,"height":68},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c7c7ecc208d4074b4807be0d2e47dbc","type":"section_header","conversion_output":false,"children_ids":["5e732aec6ddc40be8a205f64c28c2e7d"],"text":"","text_display":""},{"cnt":[[245,2071],[1291,2071],[1291,2127],[245,2127]],"region":{"top_left_x":244,"top_left_y":2071,"width":1048,"height":56},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e732aec6ddc40be8a205f64c28c2e7d","type":"text","conversion_output":true,"parent_id":"5c7c7ecc208d4074b4807be0d2e47dbc","text":"8.5.3 Analysis of Secondary Endpoints","text_display":"\n\n\\subsection*{8.5.3 Analysis of Secondary Endpoints}","confidence":0.99853515625,"confidence_rate":0.9999650978071315},{"cnt":[[245,2166],[1880,2166],[1880,2215],[245,2215]],"region":{"top_left_x":244,"top_left_y":2165,"width":1636,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b19e82d3ad7741139fcb144381545b99","type":"text","conversion_output":true,"text":"Descriptive statistics for secondary efficacy endpoints will be presented by time point (visit) and","text_display":"\n\nDescriptive statistics for secondary efficacy endpoints will be presented by time point (visit) and","confidence":0.9980480668600649,"confidence_rate":0.9999812132472036},{"cnt":[[245,2217],[526,2217],[526,2262],[245,2262]],"region":{"top_left_x":244,"top_left_y":2217,"width":283,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b44d5aaee4084205a0b06017835bb730","type":"text","conversion_output":true,"text":"treatment group.","text_display":" treatment group.","confidence":1,"confidence_rate":1},{"cnt":[[245,2303],[1880,2303],[1880,2353],[245,2353]],"region":{"top_left_x":244,"top_left_y":2303,"width":1636,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d42b3985aba4367a0301b86963649e3","type":"text","conversion_output":true,"text":"The same ANOVA model used for the primary endpoint will be used to assess the treatment","text_display":"\n\nThe same ANOVA model used for the primary endpoint will be used to assess the treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,2350],[1880,2350],[1880,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2350,"width":1636,"height":52},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c276114185945d0a1841ffe17eeed70","type":"text","conversion_output":true,"text":"effect on continuous secondary endpoints such as MRI endpoints, WOMAC endpoints (total,","text_display":" effect on continuous secondary endpoints such as MRI endpoints, WOMAC endpoints (total,","confidence":1,"confidence_rate":1},{"cnt":[[245,2398],[1762,2398],[1762,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2397,"width":1518,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a9830c722ff4528aa92025914c17304","type":"text","conversion_output":true,"text":"pain, function, and stiffness scores), and X-ray endpoints at each time point and over time.","text_display":" pain, function, and stiffness scores), and X-ray endpoints at each time point and over time.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d199a74392a4d7793dd8f847cf8f4d5","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8db4b24b9be408cab08208823b9203f","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc9128d7d6bb48d0b12e91f3bbd990c7","type":"page_info","conversion_output":false,"text":"91/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-092","page":92,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2097f3fa94ea4f52be695c69418b481e","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3666c504b9414d0da4a3b9a06d5afd45","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f774f6c64d0d4bbe9574c448c14af386","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8b2059be5534d2a8a635043e521bd4e","type":"text","conversion_output":true,"text":"Logistic regression will be used to assess the treatment effect on the binary efficacy endpoints","text_display":"\n\nLogistic regression will be used to assess the treatment effect on the binary efficacy endpoints","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1882,329],[1882,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1639,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e584d0d043164e50ac2030c4eccff78c","type":"text","conversion_output":true,"text":"such as the OMERACT-OARSI responder rate. Point estimates for each pairwise comparison","text_display":" such as the OMERACT-OARSI responder rate. Point estimates for each pairwise comparison","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1233,374],[1233,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":990,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c99414b544e643b8ae19cd59a1299364","type":"text","conversion_output":true,"text":"and corresponding \\(95 \\%\\) CIs and p -values will be provided.","text_display":" and corresponding \\(95 \\%\\) CIs and p -values will be provided.","confidence":0.9604449496707258,"confidence_rate":0.9994317303621918},{"cnt":[[236,460],[939,460],[939,535],[236,535]],"region":{"top_left_x":236,"top_left_y":459,"width":703,"height":76},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"501ab90ef5a74addaaad1340403d9ba5","type":"section_header","conversion_output":false,"children_ids":["030f4afa283640d2bcb2f99253868c55"],"text":"","text_display":""},{"cnt":[[245,466],[930,466],[930,529],[245,529]],"region":{"top_left_x":244,"top_left_y":466,"width":687,"height":63},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"030f4afa283640d2bcb2f99253868c55","type":"text","conversion_output":true,"parent_id":"501ab90ef5a74addaaad1340403d9ba5","text":"8.5.4 Safety Analyses","text_display":"\n\n\\subsection*{8.5.4 Safety Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,614],[245,614]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da8262c02275496fb95247bf3f17310c","type":"text","conversion_output":true,"text":"Safety data will be summarized descriptively overall and by treatment group, using the Safety","text_display":"\n\nSafety data will be summarized descriptively overall and by treatment group, using the Safety","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[475,610],[475,664],[245,664]],"region":{"top_left_x":244,"top_left_y":610,"width":231,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f754cffc37d54854be6c082bad927989","type":"text","conversion_output":true,"text":"Analysis Set.","text_display":" Analysis Set.","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1880,700],[1880,752],[245,752]],"region":{"top_left_x":244,"top_left_y":700,"width":1636,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d9e358aa5944cd7b97ac0bddafe0065","type":"text","conversion_output":true,"text":"AEs will be coded using the latest available version of the Medical Dictionary for Regulatory","text_display":"\n\nAEs will be coded using the latest available version of the Medical Dictionary for Regulatory","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,748],[629,748],[629,799],[245,799]],"region":{"top_left_x":244,"top_left_y":747,"width":386,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb1755ff22414c8a97d16dec0805bdb0","type":"text","conversion_output":true,"text":"Activities (MedDRA).","text_display":" Activities (MedDRA).","confidence":1,"confidence_rate":1},{"cnt":[[245,838],[1880,838],[1880,889],[245,889]],"region":{"top_left_x":244,"top_left_y":837,"width":1636,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8dbd368985a47c58c45739e88318d32","type":"text","conversion_output":true,"text":"All local and systemic AEs will be reported overall, by severity, and by relationship to trial drug,","text_display":"\n\nAll local and systemic AEs will be reported overall, by severity, and by relationship to trial drug,","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1867,885],[1867,939],[245,939]],"region":{"top_left_x":244,"top_left_y":885,"width":1623,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53847b00e8ec4e658d490a7640da9fa4","type":"text","conversion_output":true,"text":"and summaries will be prepared of events leading to discontinuation and events leading to death.","text_display":" and summaries will be prepared of events leading to discontinuation and events leading to death.","confidence":1,"confidence_rate":1},{"cnt":[[245,975],[1880,975],[1880,1027],[245,1027]],"region":{"top_left_x":244,"top_left_y":975,"width":1636,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ff2cac2e1764a0aa51f0bcb216258c1","type":"text","conversion_output":true,"text":"The incidence of protocol-defined AIRs and the incidence of surgical procedures occurring to the","text_display":"\n\nThe incidence of protocol-defined AIRs and the incidence of surgical procedures occurring to the","confidence":1,"confidence_rate":1},{"cnt":[[245,1023],[1173,1023],[1173,1076],[245,1076]],"region":{"top_left_x":244,"top_left_y":1022,"width":930,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e24e41590eb8437098b92868585ff385","type":"text","conversion_output":true,"text":"target knee during the trial will be tabulated separately.","text_display":" target knee during the trial will be tabulated separately.","confidence":1,"confidence_rate":1},{"cnt":[[245,1113],[1813,1113],[1813,1164],[245,1164]],"region":{"top_left_x":244,"top_left_y":1112,"width":1570,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eac92587b7104f47bdc1c2310ccb45b6","type":"text","conversion_output":true,"text":"Laboratory safety parameters and vital signs will be descriptively summarized as appropriate.","text_display":"\n\nLaboratory safety parameters and vital signs will be descriptively summarized as appropriate.","confidence":1,"confidence_rate":1},{"cnt":[[236,1199],[1244,1199],[1244,1270],[236,1270]],"region":{"top_left_x":236,"top_left_y":1198,"width":1008,"height":72},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"751b2a94c7cb40ef907ec4622487fcce","type":"section_header","conversion_output":false,"children_ids":["276d7abdc05a4dcdb09c30c8f571955f"],"text":"","text_display":""},{"cnt":[[245,1203],[1235,1203],[1235,1263],[245,1263]],"region":{"top_left_x":244,"top_left_y":1203,"width":992,"height":61},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"276d7abdc05a4dcdb09c30c8f571955f","type":"text","conversion_output":true,"parent_id":"751b2a94c7cb40ef907ec4622487fcce","text":"8.5.5 Analysis of Further Endpoints","text_display":"\n\n\\subsection*{8.5.5 Analysis of Further Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[1880,1302],[1880,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1301,"width":1636,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"602559651cd74c4c8e59cb209a6e0ea0","type":"text","conversion_output":true,"text":"The following domains will be described overall and by treatment group using summary","text_display":"\n\nThe following domains will be described overall and by treatment group using summary","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[408,1349],[408,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1349,"width":165,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26d63aa011c54bac9dbaeb03ba47e217","type":"text","conversion_output":true,"text":"statistics:","text_display":" statistics:","confidence":1,"confidence_rate":1},{"cnt":[[245,1420],[1042,1420],[1042,1472],[245,1472]],"region":{"top_left_x":244,"top_left_y":1420,"width":798,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c961726f942c41a6a43be16e5eff9f96","type":"text","conversion_output":true,"text":"- Disposition of subjects and discontinuations","text_display":"\n- Disposition of subjects and discontinuations","confidence":1,"confidence_rate":1},{"cnt":[[245,1491],[625,1491],[625,1540],[245,1540]],"region":{"top_left_x":244,"top_left_y":1491,"width":382,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07d77fc797a74a948fbb0ea9bf0cb47a","type":"text","conversion_output":true,"text":"- Protocol deviations","text_display":"\n- Protocol deviations","confidence":1,"confidence_rate":1},{"cnt":[[245,1564],[1399,1564],[1399,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1564,"width":1155,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d14a8434730408ba4b37e9bd9d35d45","type":"text","conversion_output":true,"text":"- Demographics, medical history, and other baseline characteristics","text_display":"\n- Demographics, medical history, and other baseline characteristics","confidence":1,"confidence_rate":1},{"cnt":[[245,1637],[1880,1637],[1880,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1637,"width":1636,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2566e72650154bb292dfa3f8d63915f9","type":"text","conversion_output":true,"text":"- Past and concomitant medications and procedures, with particular attention to pain","text_display":"\n- Past and concomitant medications and procedures, with particular attention to pain","confidence":1,"confidence_rate":1},{"cnt":[[292,1684],[505,1684],[505,1729],[292,1729]],"region":{"top_left_x":292,"top_left_y":1684,"width":213,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39839292ae614e6da3fe21eba1c77344","type":"text","conversion_output":true,"text":"medications","text_display":" medications","confidence":1,"confidence_rate":1},{"cnt":[[245,1755],[1738,1755],[1738,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1755,"width":1495,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f917529911ee4d489ac2cc9ccd536bb4","type":"text","conversion_output":true,"text":"- Treatment compliance and exposure, as assessed by the number of injections received","text_display":"\n- Treatment compliance and exposure, as assessed by the number of injections received","confidence":1,"confidence_rate":1},{"cnt":[[245,1843],[1880,1843],[1880,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1843,"width":1636,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77616db075d740a68e4d7c38f72ddc03","type":"text","conversion_output":true,"text":"PK sample bioanalysis will be performed by Merck Serono NCD-DMPK; and PK data analyses,","text_display":"\n\nPK sample bioanalysis will be performed by Merck Serono NCD-DMPK; and PK data analyses,","confidence":1,"confidence_rate":1},{"cnt":[[245,1893],[1880,1893],[1880,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1892,"width":1636,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"913fbe1198d64ae496fd6217951b2f07","type":"text","conversion_output":true,"text":"as well as investigation of the relationship between dosing (dose and regimen), cartilage","text_display":" as well as investigation of the relationship between dosing (dose and regimen), cartilage","confidence":1,"confidence_rate":1},{"cnt":[[245,1942],[1880,1942],[1880,1992],[245,1992]],"region":{"top_left_x":244,"top_left_y":1942,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f72a472128204946adb60fe9928eb1bd","type":"text","conversion_output":true,"text":"structure, and clinical scores as a function of time will be performed by Merck Serono","text_display":" structure, and clinical scores as a function of time will be performed by Merck Serono","confidence":1,"confidence_rate":1},{"cnt":[[245,1989],[629,1989],[629,2039],[245,2039]],"region":{"top_left_x":244,"top_left_y":1989,"width":386,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28aa02c026174346ba91a511970184cd","type":"text","conversion_output":true,"text":"Exploratory Medicine.","text_display":" Exploratory Medicine.","confidence":1,"confidence_rate":1},{"cnt":[[245,2080],[1884,2080],[1884,2129],[245,2129]],"region":{"top_left_x":244,"top_left_y":2079,"width":1641,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46082a109e424af29415bb662924b793","type":"text","conversion_output":true,"text":"Exploratory biomarker sample and data analyses will be performed under the responsibility of","text_display":"\n\nExploratory biomarker sample and data analyses will be performed under the responsibility of","confidence":1,"confidence_rate":1},{"cnt":[[245,2127],[1880,2127],[1880,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2126,"width":1636,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f850d7a210bc4dbba95425369275e504","type":"text","conversion_output":true,"text":"Merck Serono NCD - Biomarker Technologies. The sample analytes will be further specified in","text_display":" Merck Serono NCD - Biomarker Technologies. The sample analytes will be further specified in","confidence":1,"confidence_rate":1},{"cnt":[[245,2174],[1880,2174],[1880,2224],[245,2224]],"region":{"top_left_x":244,"top_left_y":2174,"width":1636,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ea99372009e4d348a0175f89784af6e","type":"text","conversion_output":true,"text":"the Manual of Procedures (MOP), and data analysis will be described in an Exploratory","text_display":" the Manual of Procedures (MOP), and data analysis will be described in an Exploratory","confidence":1,"confidence_rate":1},{"cnt":[[245,2221],[1880,2221],[1880,2273],[245,2273]],"region":{"top_left_x":244,"top_left_y":2221,"width":1636,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfd32b4c8df44213952feaf9a27fb7ff","type":"text","conversion_output":true,"text":"Biomarkers Statistical Analysis Plan (SAP). Results will be reported separately in an Exploratory","text_display":" Biomarkers Statistical Analysis Plan (SAP). Results will be reported separately in an Exploratory","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[580,2269],[580,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2268,"width":337,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e9afb47d4ac4517bc345b30dd6ed246","type":"text","conversion_output":true,"text":"Biomarkers Report.","text_display":" Biomarkers Report.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":37,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"230ccdad57514bf6937ba5f6ef004161","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ce5b284441224744ab34ea8ae835039d","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95663a2b940f4743ba8ba48812645824","type":"page_info","conversion_output":false,"text":"92/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-093","page":93,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6314a43c37104aa4871a8e487acefde8","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"448f8402b21c4e72b83abc5ff08f2dd9","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be95af8696d64183b7599cd8b41247ea","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,277],[1201,277],[1201,337],[241,337]],"region":{"top_left_x":240,"top_left_y":277,"width":961,"height":61},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92c8c2dbad1c4caebf04082d73dac269","type":"section_header","conversion_output":false,"children_ids":["35990fde217b4e3a9ebfcffaf59e000f"],"text":"","text_display":""},{"cnt":[[245,284],[1197,284],[1197,333],[245,333]],"region":{"top_left_x":244,"top_left_y":283,"width":953,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35990fde217b4e3a9ebfcffaf59e000f","type":"text","conversion_output":true,"parent_id":"92c8c2dbad1c4caebf04082d73dac269","text":"Analysis of Data from the Extended Follow-up Phase","text_display":"\n\n\\section*{Analysis of Data from the Extended Follow-up Phase}","confidence":1,"confidence_rate":1},{"cnt":[[245,370],[1882,370],[1882,421],[245,421]],"region":{"top_left_x":244,"top_left_y":369,"width":1639,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46ccb643a6b54223871613bcc65eb52a","type":"text","conversion_output":true,"text":"Data reported during the extended follow-up phase will be presented mainly using descriptive","text_display":"\n\nData reported during the extended follow-up phase will be presented mainly using descriptive","confidence":1,"confidence_rate":1},{"cnt":[[245,421],[406,421],[406,462],[245,462]],"region":{"top_left_x":244,"top_left_y":421,"width":163,"height":41},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46f37ddd00884e04bbff88e8bfcc79ad","type":"text","conversion_output":true,"text":"statistics.","text_display":" statistics.","confidence":1,"confidence_rate":1},{"cnt":[[241,503],[967,503],[967,563],[241,563]],"region":{"top_left_x":240,"top_left_y":502,"width":727,"height":61},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb0ea464126f4eb89a7d4bef4dd89fc9","type":"section_header","conversion_output":false,"children_ids":["9952955c51cd4ff386ca2aefbf72888a"],"text":"","text_display":""},{"cnt":[[245,507],[960,507],[960,559],[245,559]],"region":{"top_left_x":244,"top_left_y":507,"width":717,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9952955c51cd4ff386ca2aefbf72888a","type":"text","conversion_output":true,"parent_id":"cb0ea464126f4eb89a7d4bef4dd89fc9","text":"Exploratory Pharmacometric Modeling","text_display":"\n\n\\section*{Exploratory Pharmacometric Modeling}","confidence":1,"confidence_rate":1},{"cnt":[[245,597],[1884,597],[1884,647],[245,647]],"region":{"top_left_x":244,"top_left_y":597,"width":1641,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea2fe13a7d544f7283ac4b0c374b25f4","type":"text","conversion_output":true,"text":"A modeling analysis will be performed in order to evaluate the disease-modifying effect of","text_display":"\n\nA modeling analysis will be performed in order to evaluate the disease-modifying effect of","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1695,645],[1695,696],[245,696]],"region":{"top_left_x":244,"top_left_y":644,"width":1452,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01a785728c654604966fb0df2261731a","type":"text","conversion_output":true,"text":"sprifermin, i.e., improvement of cartilage structure and clinical symptoms (WOMAC).","text_display":" sprifermin, i.e., improvement of cartilage structure and clinical symptoms (WOMAC).","confidence":0.9970724578015506,"confidence_rate":0.9999666842387093},{"cnt":[[245,735],[1880,735],[1880,784],[245,784]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3de1ac16ef4e4b4dad2a89c921abcfd2","type":"text","conversion_output":true,"text":"In particular, the relationship between cartilage structure changes and improvement of clinical","text_display":"\n\nIn particular, the relationship between cartilage structure changes and improvement of clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1880,782],[1880,831],[245,831]],"region":{"top_left_x":244,"top_left_y":782,"width":1636,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cd747546c504031a58e10774bf6b1b8","type":"text","conversion_output":true,"text":"symptoms will be investigated, in order to support the selection of the optimal dose/dosing","text_display":" symptoms will be investigated, in order to support the selection of the optimal dose/dosing","confidence":1,"confidence_rate":1},{"cnt":[[245,831],[662,831],[662,879],[245,879]],"region":{"top_left_x":244,"top_left_y":831,"width":418,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"feaf986bd4e44a3394f89da3fe7943f1","type":"text","conversion_output":true,"text":"regimen for future trials.","text_display":" regimen for future trials.","confidence":1,"confidence_rate":1},{"cnt":[[245,920],[1880,920],[1880,969],[245,969]],"region":{"top_left_x":244,"top_left_y":919,"width":1636,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6331a70c1bcd4d48b3fadba8cf0a9a48","type":"text","conversion_output":true,"text":"In order to derive a better understanding of sprifermin effects, other potential","text_display":"\n\nIn order to derive a better understanding of sprifermin effects, other potential","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1738,967],[1738,1018],[245,1018]],"region":{"top_left_x":244,"top_left_y":966,"width":1495,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45300a0a96e348a5a9eba77f87c07bec","type":"text","conversion_output":true,"text":"influencing/confounding factors such as the placebo effect will be included in the model.","text_display":" influencing/confounding factors such as the placebo effect will be included in the model.","confidence":1,"confidence_rate":1},{"cnt":[[245,1057],[1880,1057],[1880,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1057,"width":1636,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f09444f332af4301bbf13db97b76bbaf","type":"text","conversion_output":true,"text":"The development of the models implies a covariate analysis to explore the influence of various","text_display":"\n\nThe development of the models implies a covariate analysis to explore the influence of various","confidence":1,"confidence_rate":1},{"cnt":[[245,1104],[1880,1104],[1880,1158],[245,1158]],"region":{"top_left_x":244,"top_left_y":1104,"width":1636,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db3fc1809d0b4bf0b11496c328dc1b23","type":"text","conversion_output":true,"text":"potential predictors of variability, e.g., demographics/anthropometrics, biomarkers (including","text_display":" potential predictors of variability, e.g., demographics/anthropometrics, biomarkers (including","confidence":1,"confidence_rate":1},{"cnt":[[245,1154],[999,1154],[999,1205],[245,1205]],"region":{"top_left_x":244,"top_left_y":1153,"width":756,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02084296454e44168c396ffd4ab0dc2c","type":"text","conversion_output":true,"text":"PGt markers), and concomitant medications.","text_display":" PGt markers), and concomitant medications.","confidence":1,"confidence_rate":1},{"cnt":[[245,1242],[1882,1242],[1882,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1241,"width":1639,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da4f710a435249b382d7590d2d9ab1fb","type":"text","conversion_output":true,"text":"Finally, simulations will be performed to address various scenarios, to support decision making","text_display":"\n\nFinally, simulations will be performed to address various scenarios, to support decision making","confidence":1,"confidence_rate":1},{"cnt":[[245,1293],[763,1293],[763,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1293,"width":519,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98a44aa35b4c423f9e8b32ea8be3d2ba","type":"text","conversion_output":true,"text":"and planning of future studies.","text_display":" and planning of future studies.","confidence":1,"confidence_rate":1},{"cnt":[[245,1379],[1886,1379],[1886,1433],[245,1433]],"region":{"top_left_x":244,"top_left_y":1379,"width":1643,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d18ab7445df14881b9668d8706b67267","type":"text","conversion_output":true,"text":"Additional models focusing on other secondary/exploratory endpoints could be developed if","text_display":"\n\nAdditional models focusing on other secondary/exploratory endpoints could be developed if","confidence":1,"confidence_rate":1},{"cnt":[[245,1429],[593,1429],[593,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1428,"width":349,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f0be42e051d479fb2c173a12510dd03","type":"text","conversion_output":true,"text":"deemed appropriate.","text_display":" deemed appropriate.","confidence":1,"confidence_rate":1},{"cnt":[[245,1517],[1882,1517],[1882,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1516,"width":1639,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f414b455c8b04b4ab50cfb743a57829b","type":"text","conversion_output":true,"text":"The details of modeling and simulation analyses will be described in a Modeling and Simulation","text_display":"\n\nThe details of modeling and simulation analyses will be described in a Modeling and Simulation","confidence":1,"confidence_rate":1},{"cnt":[[245,1566],[582,1566],[582,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1566,"width":339,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"647222c8a3594bbebeec68a768d10218","type":"text","conversion_output":true,"text":"Data Analysis Plan.","text_display":" Data Analysis Plan.","confidence":1,"confidence_rate":1},{"cnt":[[241,1654],[956,1654],[956,1721],[241,1721]],"region":{"top_left_x":240,"top_left_y":1654,"width":717,"height":67},"line":26,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"37eee1041b1045939a9be996880d2443","type":"section_header","conversion_output":false,"children_ids":["3845ec6b056046c8b291421043e56e80","f2fcbd3c9da348c1ba572645b1dea149"],"text":"","text_display":""},{"cnt":[[243,1659],[316,1659],[316,1710],[243,1710]],"region":{"top_left_x":242,"top_left_y":1658,"width":74,"height":53},"line":27,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"3845ec6b056046c8b291421043e56e80","type":"text","conversion_output":true,"parent_id":"37eee1041b1045939a9be996880d2443","text":"8.6","text_display":"\n\n\\section*{8.6","confidence":1,"confidence_rate":1},{"cnt":[[593,1659],[952,1659],[952,1717],[593,1717]],"region":{"top_left_x":592,"top_left_y":1658,"width":360,"height":59},"line":28,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"f2fcbd3c9da348c1ba572645b1dea149","type":"text","conversion_output":true,"parent_id":"37eee1041b1045939a9be996880d2443","text":"Interim Analysis","text_display":" Interim Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[771,1753],[771,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1753,"width":528,"height":54},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5596c9623034c93904fa532a7db9fe1","type":"text","conversion_output":true,"text":"No interim analysis is planned.","text_display":"\n\nNo interim analysis is planned.","confidence":1,"confidence_rate":1},{"cnt":[[245,1841],[1880,1841],[1880,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1841,"width":1636,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc8a3d3758984365975f7fe42597723d","type":"text","conversion_output":true,"text":"An IDMC will be constituted and will perform periodic reviews to evaluate the safety of the","text_display":"\nAn IDMC will be constituted and will perform periodic reviews to evaluate the safety of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1891],[1880,1891],[1880,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1890,"width":1636,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35bb5da01ca4408191fbc8e855c9f2a6","type":"text","conversion_output":true,"text":"subjects participating in the trial on an ongoing basis. Detailed description of the safety","text_display":" subjects participating in the trial on an ongoing basis. Detailed description of the safety","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1222,1938],[1222,1989],[245,1989]],"region":{"top_left_x":244,"top_left_y":1937,"width":979,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"950a5aec2ce84b52835ad12a53decff6","type":"text","conversion_output":true,"text":"monitoring will be specified in a dedicated IDMC charter.","text_display":" monitoring will be specified in a dedicated IDMC charter.","confidence":1,"confidence_rate":1},{"cnt":[[243,2028],[284,2028],[284,2084],[243,2084]],"region":{"top_left_x":242,"top_left_y":2028,"width":42,"height":56},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ed843fc8a7c4c7f935ae4a5641d03e1","type":"section_header","conversion_output":false,"children_ids":["77d5ec0e15a74900900d750a7f3518e9"],"text":"","text_display":""},{"cnt":[[243,2032],[279,2032],[279,2080],[243,2080]],"region":{"top_left_x":242,"top_left_y":2032,"width":38,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77d5ec0e15a74900900d750a7f3518e9","type":"text","conversion_output":true,"parent_id":"7ed843fc8a7c4c7f935ae4a5641d03e1","text":"9","text_display":"\n\n\\section*{9}","confidence":1,"confidence_rate":1},{"cnt":[[591,2024],[1265,2024],[1265,2093],[591,2093]],"region":{"top_left_x":590,"top_left_y":2023,"width":676,"height":70},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dcb04f142cc4b3da1c3539d5e03a03b","type":"section_header","conversion_output":false,"children_ids":["c0d7fa2652844746905f19c7aaf9546e"],"text":"","text_display":""},{"cnt":[[597,2032],[1261,2032],[1261,2086],[597,2086]],"region":{"top_left_x":597,"top_left_y":2032,"width":665,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0d7fa2652844746905f19c7aaf9546e","type":"text","conversion_output":true,"parent_id":"7dcb04f142cc4b3da1c3539d5e03a03b","text":"Ethical and Regulatory Aspects","text_display":"\n\n\\section*{Ethical and Regulatory Aspects}","confidence":1,"confidence_rate":1},{"cnt":[[241,2125],[316,2125],[316,2181],[241,2181]],"region":{"top_left_x":240,"top_left_y":2124,"width":76,"height":57},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c67a9b7e3e74e778d179e600e16b956","type":"section_header","conversion_output":false,"children_ids":["074bdc3b768b43b0914a6226a92b870d"],"text":"","text_display":""},{"cnt":[[245,2131],[312,2131],[312,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2131,"width":68,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"074bdc3b768b43b0914a6226a92b870d","type":"text","conversion_output":true,"parent_id":"8c67a9b7e3e74e778d179e600e16b956","text":"9.1","text_display":"\n\n\\section*{9.1}","confidence":1,"confidence_rate":1},{"cnt":[[589,2123],[1326,2123],[1326,2189],[589,2189]],"region":{"top_left_x":588,"top_left_y":2122,"width":738,"height":68},"line":39,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"34cfd71eeb894200ad691f627538d30c","type":"section_header","conversion_output":false,"children_ids":["2e3ca5dc7a90432e97a60bb38fd9cd85"],"text":"","text_display":""},{"cnt":[[595,2127],[1321,2127],[1321,2185],[595,2185]],"region":{"top_left_x":595,"top_left_y":2126,"width":727,"height":59},"line":40,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"2e3ca5dc7a90432e97a60bb38fd9cd85","type":"text","conversion_output":true,"parent_id":"34cfd71eeb894200ad691f627538d30c","text":"Responsibilities of the Investigator","text_display":"\n\n\\section*{Responsibilities of the Investigator}","confidence":1,"confidence_rate":1},{"cnt":[[245,2221],[1880,2221],[1880,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2221,"width":1636,"height":55},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78cf43fa01e341ec9d9247dad8f042db","type":"text","conversion_output":true,"text":"The Investigator is responsible for the conduct of the trial at his/her site. S/he will ensure that the","text_display":"\n\nThe Investigator is responsible for the conduct of the trial at his/her site. S/he will ensure that the","confidence":0.98291015625,"confidence_rate":0.999840405694678},{"cnt":[[245,2271],[1880,2271],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2270,"width":1636,"height":53},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6894028ea58542bba2719671219ce41b","type":"text","conversion_output":true,"text":"trial is performed in accordance with the clinical trial protocol and with the ethical principles that","text_display":" trial is performed in accordance with the clinical trial protocol and with the ethical principles that","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1880,2320],[1880,2370],[245,2370]],"region":{"top_left_x":244,"top_left_y":2320,"width":1636,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd61ea80d4d34da4a6256b3a010f18df","type":"text","conversion_output":true,"text":"have their origin in the Declaration of Helsinki, as well as with the ICH Note for Guidance on","text_display":" have their origin in the Declaration of Helsinki, as well as with the ICH Note for Guidance on","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1880,2368],[1880,2419],[245,2419]],"region":{"top_left_x":244,"top_left_y":2367,"width":1636,"height":53},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5078d0420fc459fb73dec7adc3d819a","type":"text","conversion_output":true,"text":"Good Clinical Practice (ICH Topic E6, 1996) and applicable regulatory requirements. In","text_display":" Good Clinical Practice (ICH Topic E6, 1996) and applicable regulatory requirements. In","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d058568c2c6a490eb0f0e8dd927e7d6b","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2548],[389,2545],[390,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":44},"line":46,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"295ace24dd364601acd2ea60ad0e1ac6","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.998046875,"confidence_rate":0.9998696728376023},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"555744de1d214c00a6826514960c9183","type":"page_info","conversion_output":false,"text":"93/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-094","page":94,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ad13f0a720a4a79b4531d398ce88f8f","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dac8701e7330477380483088a12bb24c","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56502696a8284031bb6f263c67a05061","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1882,279],[1882,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1639,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e565996ef1e4bf7b6c200d0d27f5912","type":"text","conversion_output":true,"text":"particular, the Investigator must ensure that only subjects who have given their informed consent","text_display":"\nparticular, the Investigator must ensure that only subjects who have given their informed consent","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[683,329],[683,374],[245,374]],"region":{"top_left_x":244,"top_left_y":328,"width":440,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"947264a09aad42b39d38edff863a01aa","type":"text","conversion_output":true,"text":"are included into the trial.","text_display":" are included into the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1880,417],[1880,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"add1362de06d4421bec97b9b89ca60a0","type":"text","conversion_output":true,"text":"In 1998, the US Food and Drug Administration (FDA) introduced a regulation (21 CFR, Part 54)","text_display":"\n\nIn 1998, the US Food and Drug Administration (FDA) introduced a regulation (21 CFR, Part 54)","confidence":0.9975600242614746,"confidence_rate":0.999974815190026},{"cnt":[[245,466],[1882,466],[1882,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1639,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa5b8b5639534ef8b34de3aeeca71ea4","type":"text","conversion_output":true,"text":"entitled \"Financial Disclosure by Clinical Investigators\". For trials conducted in any country that","text_display":" entitled \"Financial Disclosure by Clinical Investigators\". For trials conducted in any country that","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1880,516],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec145acad225487f8fb4be5963676875","type":"text","conversion_output":true,"text":"could result in a product submission to the FDA for marketing approval and could contribute","text_display":" could result in a product submission to the FDA for marketing approval and could contribute","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e736ade895743e9b4f31452799c8762","type":"text","conversion_output":true,"text":"significantly to the demonstration of efficacy and safety of the IMP (named \"covered trials\" by","text_display":" significantly to the demonstration of efficacy and safety of the IMP (named \"covered trials\" by","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1880,610],[1880,660],[245,660]],"region":{"top_left_x":244,"top_left_y":610,"width":1636,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4268b1ec31b744209ace35311e7bce93","type":"text","conversion_output":true,"text":"the FDA), the Investigator and all sub-Investigators are obliged to disclose any financial interest","text_display":" the FDA), the Investigator and all sub-Investigators are obliged to disclose any financial interest","confidence":1,"confidence_rate":1},{"cnt":[[245,657],[1880,657],[1880,707],[245,707]],"region":{"top_left_x":244,"top_left_y":657,"width":1636,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5705dfc8da5345ef8dfd482c567808fa","type":"text","conversion_output":true,"text":"which they, their spouses or their dependent children may have in the Sponsor or the Sponsor's","text_display":" which they, their spouses or their dependent children may have in the Sponsor or the Sponsor's","confidence":1,"confidence_rate":1},{"cnt":[[245,705],[1880,705],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":704,"width":1636,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a54f729da9014098a04b85dafeb89d98","type":"text","conversion_output":true,"text":"product under study. This information is required during the trial and for 12 months following","text_display":" product under study. This information is required during the trial and for 12 months following","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[634,752],[634,806],[245,806]],"region":{"top_left_x":244,"top_left_y":751,"width":390,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd89019a0fbc45c7a0d0287fdebebf75","type":"text","conversion_output":true,"text":"completion of the trial.","text_display":" completion of the trial.","confidence":1,"confidence_rate":1},{"cnt":[[241,838],[1515,838],[1515,909],[241,909]],"region":{"top_left_x":240,"top_left_y":837,"width":1275,"height":72},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e45c190cc6054cca827a3990b4be17c2","type":"section_header","conversion_output":false,"children_ids":["56ee7461f14c486fb1fbc2d6e1bd8a3a"],"text":"","text_display":""},{"cnt":[[245,846],[1510,846],[1510,902],[245,902]],"region":{"top_left_x":244,"top_left_y":846,"width":1267,"height":57},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56ee7461f14c486fb1fbc2d6e1bd8a3a","type":"text","conversion_output":true,"parent_id":"e45c190cc6054cca827a3990b4be17c2","text":"9.2 Subject Information and Informed Consent","text_display":"\n\n\\subsection*{9.2 Subject Information and Informed Consent}","confidence":0.81005859375,"confidence_rate":0.995710274292129},{"cnt":[[245,941],[1880,941],[1880,990],[245,990]],"region":{"top_left_x":244,"top_left_y":941,"width":1636,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6bacea2c72a4157b8126e4f756531c2","type":"text","conversion_output":true,"text":"An unconditional prerequisite for a subject's participation in the trial is his/her written informed","text_display":"\n\nAn unconditional prerequisite for a subject's participation in the trial is his/her written informed","confidence":1,"confidence_rate":1},{"cnt":[[245,988],[1880,988],[1880,1038],[245,1038]],"region":{"top_left_x":244,"top_left_y":988,"width":1636,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cf5efc9cc5648bcbd62c6f779786b6e","type":"text","conversion_output":true,"text":"consent. The subject's written informed consent to participate in the trial must be given before","text_display":" consent. The subject's written informed consent to participate in the trial must be given before","confidence":1,"confidence_rate":1},{"cnt":[[245,1036],[939,1036],[939,1087],[245,1087]],"region":{"top_left_x":244,"top_left_y":1035,"width":695,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ceef11f4adf0486c9a63cb1697744bb0","type":"text","conversion_output":true,"text":"any trial-related activities are carried out.","text_display":" any trial-related activities are carried out.","confidence":1,"confidence_rate":1},{"cnt":[[245,1126],[1880,1126],[1880,1177],[245,1177]],"region":{"top_left_x":244,"top_left_y":1125,"width":1636,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29dc4f54644948728e3194b6c903163e","type":"text","conversion_output":true,"text":"Adequate information must therefore be given to the subject by the Investigator before informed","text_display":"\n\nAdequate information must therefore be given to the subject by the Investigator before informed","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1884,1173],[1884,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1641,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61690dc431a747d5b56741176e6cf8ae","type":"text","conversion_output":true,"text":"consent is obtained (a person designated by the Investigator may give the information, if","text_display":" consent is obtained (a person designated by the Investigator may give the information, if","confidence":0.88525390625,"confidence_rate":0.998704236234106},{"cnt":[[245,1220],[1880,1220],[1880,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1220,"width":1636,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9ffadd72d424b60a8580811689bd704","type":"text","conversion_output":true,"text":"permitted by local regulations). A subject information sheet in the local language and prepared in","text_display":" permitted by local regulations). A subject information sheet in the local language and prepared in","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1880,1268],[1880,1319],[245,1319]],"region":{"top_left_x":244,"top_left_y":1267,"width":1636,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f4ec6afe061470b93972f3ce32633b7","type":"text","conversion_output":true,"text":"accordance with the Note for Guidance on Good Clinical Practice (ICH Topic E6, 1996) will be","text_display":" accordance with the Note for Guidance on Good Clinical Practice (ICH Topic E6, 1996) will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1317],[1880,1317],[1880,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1316,"width":1636,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ada6a96174eb427aa204f572ee45d54a","type":"text","conversion_output":true,"text":"provided by the Sponsor for the purpose of obtaining informed consent. In addition to providing","text_display":" provided by the Sponsor for the purpose of obtaining informed consent. In addition to providing","confidence":1,"confidence_rate":1},{"cnt":[[245,1366],[1880,1366],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1366,"width":1636,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddcc4be186574a319044c54d4d8ffd72","type":"text","conversion_output":true,"text":"this written information to a potential subject, the Investigator or his/her designate will inform","text_display":" this written information to a potential subject, the Investigator or his/her designate will inform","confidence":1,"confidence_rate":1},{"cnt":[[245,1414],[1880,1414],[1880,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"794ec3b3a2c94876998f81de409c58fa","type":"text","conversion_output":true,"text":"the subject verbally of all pertinent aspects of the trial. The language used in doing so must be","text_display":" the subject verbally of all pertinent aspects of the trial. The language used in doing so must be","confidence":1,"confidence_rate":1},{"cnt":[[245,1461],[1609,1461],[1609,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1460,"width":1366,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71c77c21178d4808b5edc9a0e8946713","type":"text","conversion_output":true,"text":"chosen so that the information can be fully and readily understood by laypersons.","text_display":" chosen so that the information can be fully and readily understood by laypersons.","confidence":1,"confidence_rate":1},{"cnt":[[245,1551],[1882,1551],[1882,1603],[245,1603]],"region":{"top_left_x":244,"top_left_y":1551,"width":1639,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d6e9cbe6ede482a91bfee2ae3c634d4","type":"text","conversion_output":true,"text":"Depending on national regulations, a person other than the Investigator may inform the subject","text_display":"\n\nDepending on national regulations, a person other than the Investigator may inform the subject","confidence":0.9863345623016357,"confidence_rate":0.9998610231000642},{"cnt":[[245,1598],[707,1598],[707,1648],[245,1648]],"region":{"top_left_x":244,"top_left_y":1598,"width":463,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df77c5ec60054f6bb3a16cc8f90ff160","type":"text","conversion_output":true,"text":"and sign the ICF, as above.","text_display":" and sign the ICF, as above.","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1880,1689],[1880,1740],[245,1740]],"region":{"top_left_x":244,"top_left_y":1688,"width":1636,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"015fc2b1603f40349d548749bb786cbf","type":"text","conversion_output":true,"text":"Where the information is provided by the Investigator, the ICF must be signed and personally","text_display":"\n\nWhere the information is provided by the Investigator, the ICF must be signed and personally","confidence":1,"confidence_rate":1},{"cnt":[[245,1736],[937,1736],[937,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1735,"width":693,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6bb8538f2fe445d3bf5ca9e269ae48fc","type":"text","conversion_output":true,"text":"dated by the subject and the Investigator.","text_display":" dated by the subject and the Investigator.","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[1880,1826],[1880,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1826,"width":1636,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb8feb4db3ac4c6db9ac77656ccc89c2","type":"text","conversion_output":true,"text":"The signed and dated declaration of informed consent will remain at the Investigator's site, and","text_display":"\n\nThe signed and dated declaration of informed consent will remain at the Investigator's site, and","confidence":0.99853515625,"confidence_rate":0.9999854860688677},{"cnt":[[245,1873],[1880,1873],[1880,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1873,"width":1636,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ac5def3f53741cab2e44f103644fafa","type":"text","conversion_output":true,"text":"must be safely archived by the Investigator so that the forms can be retrieved at any time for","text_display":" must be safely archived by the Investigator so that the forms can be retrieved at any time for","confidence":0.9990236759185791,"confidence_rate":0.999990133371946},{"cnt":[[245,1921],[1880,1921],[1880,1972],[245,1972]],"region":{"top_left_x":244,"top_left_y":1920,"width":1636,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebdf6482dec1450aa54387ea94f9808b","type":"text","conversion_output":true,"text":"monitoring, auditing and inspection purposes. A copy of the signed and dated information and","text_display":" monitoring, auditing and inspection purposes. A copy of the signed and dated information and","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1246,1968],[1246,2022],[245,2022]],"region":{"top_left_x":244,"top_left_y":1967,"width":1003,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce69dcb370e646d38d1d6dd3576bfa0f","type":"text","conversion_output":true,"text":"ICF should be provided to the subject prior to participation.","text_display":" ICF should be provided to the subject prior to participation.","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1880,2058],[1880,2110],[245,2110]],"region":{"top_left_x":244,"top_left_y":2058,"width":1636,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd6ad5a4f4a24214bb83aaf561721c11","type":"text","conversion_output":true,"text":"Whenever important new information becomes available that may be relevant to the subject's","text_display":"\n\nWhenever important new information becomes available that may be relevant to the subject's","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,2108],[1880,2108],[1880,2159],[245,2159]],"region":{"top_left_x":244,"top_left_y":2107,"width":1636,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b03f6240b31b4cbab1d9f2c24c80e15a","type":"text","conversion_output":true,"text":"consent, the written subject information sheet and any other written information provided to","text_display":" consent, the written subject information sheet and any other written information provided to","confidence":1,"confidence_rate":1},{"cnt":[[245,2157],[1880,2157],[1880,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2157,"width":1636,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b535c3dd12248298bbbbd3015b6e138","type":"text","conversion_output":true,"text":"subjects will be revised by the Sponsor and be submitted again to the IEC/IRB for review and","text_display":" subjects will be revised by the Sponsor and be submitted again to the IEC/IRB for review and","confidence":1,"confidence_rate":1},{"cnt":[[245,2204],[1880,2204],[1880,2254],[245,2254]],"region":{"top_left_x":244,"top_left_y":2204,"width":1636,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bef4dc4c1354b879cf6bb0ffc5db1b2","type":"text","conversion_output":true,"text":"favorable opinion. The agreed, revised information will be provided to each subject in the trial","text_display":" favorable opinion. The agreed, revised information will be provided to each subject in the trial","confidence":1,"confidence_rate":1},{"cnt":[[245,2252],[1729,2252],[1729,2305],[245,2305]],"region":{"top_left_x":244,"top_left_y":2251,"width":1486,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad28a51cff4d4c9fa226a8a75ae2fa80","type":"text","conversion_output":true,"text":"for signing and dating. The Investigator will explain the changes to the previous version.","text_display":" for signing and dating. The Investigator will explain the changes to the previous version.","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f79f8cb8319242669b11b3b0bac22010","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2548],[389,2546],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2545,"width":146,"height":42},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"95c4048dac144f33ae2c90f0aa0d45c5","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968649},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"419643ff50f04d6385ab35b1b20f8a81","type":"page_info","conversion_output":false,"text":"94/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-095","page":95,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9fda34f9dd554859910caef32c4ad334","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ec7fdfe3773496fa9666dd4d325d7da","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"884ca9816c60402cbc651f89eeaa9e72","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,277],[920,277],[920,337],[241,337]],"region":{"top_left_x":240,"top_left_y":277,"width":680,"height":61},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6648042896574aef80e1d3034484a09d","type":"section_header","conversion_output":false,"children_ids":["1b0563a4c21c48e98100f749fea718e1"],"text":"","text_display":""},{"cnt":[[245,284],[917,284],[917,331],[245,331]],"region":{"top_left_x":244,"top_left_y":283,"width":674,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b0563a4c21c48e98100f749fea718e1","type":"text","conversion_output":true,"parent_id":"6648042896574aef80e1d3034484a09d","text":"Pharmacogenetics Informed Consent","text_display":"\n\n\\section*{Pharmacogenetics Informed Consent}","confidence":1,"confidence_rate":1},{"cnt":[[245,370],[1884,370],[1884,419],[245,419]],"region":{"top_left_x":244,"top_left_y":369,"width":1641,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c1b78be5ddb42a79d776de5ab64c15e","type":"text","conversion_output":true,"text":"All subjects who are enrolled in the trial will be eligible to participate in the optional PGt","text_display":"\n\nAll subjects who are enrolled in the trial will be eligible to participate in the optional PGt","confidence":1,"confidence_rate":1},{"cnt":[[245,419],[1880,419],[1880,468],[245,468]],"region":{"top_left_x":244,"top_left_y":418,"width":1636,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c13c6ac0e6e64bda8bdaf0c37a3407b0","type":"text","conversion_output":true,"text":"analysis (except in countries where collection of PGt samples is not allowed). Participation is","text_display":" analysis (except in countries where collection of PGt samples is not allowed). Participation is","confidence":0.97314453125,"confidence_rate":0.9997278103908489},{"cnt":[[245,466],[1732,466],[1732,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1488,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75f452f4796e4c439e0e154e095050d0","type":"text","conversion_output":true,"text":"optional, and the subjects who choose to participate will need to sign a specific PGt ICF.","text_display":" optional, and the subjects who choose to participate will need to sign a specific PGt ICF.","confidence":1,"confidence_rate":1},{"cnt":[[241,552],[1321,552],[1321,621],[241,621]],"region":{"top_left_x":240,"top_left_y":552,"width":1082,"height":69},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bd78dc140c742f0a2aace4aa8438edb","type":"section_header","conversion_output":false,"children_ids":["735c03b120934fea9814a4582f9e6b91"],"text":"","text_display":""},{"cnt":[[245,559],[1317,559],[1317,617],[245,617]],"region":{"top_left_x":244,"top_left_y":558,"width":1073,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"735c03b120934fea9814a4582f9e6b91","type":"text","conversion_output":true,"parent_id":"5bd78dc140c742f0a2aace4aa8438edb","text":"9.3 Subject Identification and Privacy","text_display":"\n\n\\subsection*{9.3 Subject Identification and Privacy}","confidence":0.9931640625,"confidence_rate":0.9998404915704762},{"cnt":[[245,653],[1882,653],[1882,703],[245,703]],"region":{"top_left_x":244,"top_left_y":653,"width":1639,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1fbe326e82545238517067b0f6202ad","type":"text","conversion_output":true,"text":"A unique subject number will be assigned to each subject at inclusion, immediately after","text_display":"\n\nA unique subject number will be assigned to each subject at inclusion, immediately after","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1880,700],[1880,752],[245,752]],"region":{"top_left_x":244,"top_left_y":700,"width":1636,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60d763b7818442ad95eabc42894be9d3","type":"text","conversion_output":true,"text":"informed consent has been obtained. This number will serve as the subject's identifier in the trial","text_display":" informed consent has been obtained. This number will serve as the subject's identifier in the trial","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[896,748],[896,793],[245,793]],"region":{"top_left_x":244,"top_left_y":747,"width":652,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f59dc0a9b66455e813d7adb32e2a718","type":"text","conversion_output":true,"text":"as well as in the clinical trial database.","text_display":" as well as in the clinical trial database.","confidence":0.99853515625,"confidence_rate":0.9999688107484693},{"cnt":[[245,838],[1882,838],[1882,887],[245,887]],"region":{"top_left_x":244,"top_left_y":837,"width":1639,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb3733a18f704ca49376a3e3c3ab267d","type":"text","conversion_output":true,"text":"The subject's data collected in the trial will be stored under this number. Only the Investigator","text_display":"\n\nThe subject's data collected in the trial will be stored under this number. Only the Investigator","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1880,885],[1880,937],[245,937]],"region":{"top_left_x":244,"top_left_y":885,"width":1636,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04becfaff6bb414ba30596aa98799b9a","type":"text","conversion_output":true,"text":"will be able to link the subject's trial data to the subject via an identification list kept at the site.","text_display":" will be able to link the subject's trial data to the subject via an identification list kept at the site.","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,935],[1880,935],[1880,986],[245,986]],"region":{"top_left_x":244,"top_left_y":934,"width":1636,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc75ee69b8a74abf8b6a55a94f6eb14d","type":"text","conversion_output":true,"text":"The subject's original medical data that are reviewed at the site during source data verification","text_display":" The subject's original medical data that are reviewed at the site during source data verification","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,984],[1738,984],[1738,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":983,"width":1495,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88c1968d36624d28966e8994728e30da","type":"text","conversion_output":true,"text":"by the Monitor, audits and Health Authority inspections will be kept strictly confidential.","text_display":" by the Monitor, audits and Health Authority inspections will be kept strictly confidential.","confidence":1,"confidence_rate":1},{"cnt":[[245,1072],[1880,1072],[1880,1124],[245,1124]],"region":{"top_left_x":244,"top_left_y":1072,"width":1636,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee66e42e85db4ca5ac12578f63a127cf","type":"text","conversion_output":true,"text":"Data protection and privacy regulations will be observed in capturing, forwarding, processing,","text_display":"\n\nData protection and privacy regulations will be observed in capturing, forwarding, processing,","confidence":1,"confidence_rate":1},{"cnt":[[245,1121],[1880,1121],[1880,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1121,"width":1636,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cee8033933844f81ba5cb5fe40c8f394","type":"text","conversion_output":true,"text":"and storing subject data. Subjects will be informed accordingly, and will be requested to give","text_display":" and storing subject data. Subjects will be informed accordingly, and will be requested to give","confidence":1,"confidence_rate":1},{"cnt":[[245,1164],[1626,1164],[1626,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1164,"width":1383,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e124d6b04b14f41923741896db41337","type":"text","conversion_output":true,"text":"their consent on data handling procedures in accordance with national regulations.","text_display":" their consent on data handling procedures in accordance with national regulations.","confidence":1,"confidence_rate":1},{"cnt":[[243,1255],[986,1255],[986,1313],[243,1313]],"region":{"top_left_x":242,"top_left_y":1254,"width":745,"height":59},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"240c3c4bd9d8415f9db5ee7d7f3dbf55","type":"section_header","conversion_output":false,"children_ids":["56dcf1b4afff4999b8af729c584797a8"],"text":"","text_display":""},{"cnt":[[245,1259],[982,1259],[982,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1258,"width":738,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56dcf1b4afff4999b8af729c584797a8","type":"text","conversion_output":true,"parent_id":"240c3c4bd9d8415f9db5ee7d7f3dbf55","text":"Confidentiality of Pharmacogenetic Data","text_display":"\n\n\\section*{Confidentiality of Pharmacogenetic Data}","confidence":0.99951171875,"confidence_rate":0.9999889000502842},{"cnt":[[245,1345],[1880,1345],[1880,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1344,"width":1636,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be3a674c8e804f3195b77fcc144f0c9a","type":"text","conversion_output":true,"text":"The results of the genetic analysis are for research purposes only. The results of the genetic tests","text_display":"\n\nThe results of the genetic analysis are for research purposes only. The results of the genetic tests","confidence":1,"confidence_rate":1},{"cnt":[[245,1394],[1880,1394],[1880,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1394,"width":1636,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00d9690629ea413e8e1aef8e20619d01","type":"text","conversion_output":true,"text":"will not be made available to the subject, members of his/her family, his/her personal physician,","text_display":" will not be made available to the subject, members of his/her family, his/her personal physician,","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1055,1439],[1055,1493],[245,1493]],"region":{"top_left_x":244,"top_left_y":1439,"width":811,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac8162e5898e44d99646ba5d058733c2","type":"text","conversion_output":true,"text":"or other third parties, except as specified below.","text_display":" or other third parties, except as specified below.","confidence":1,"confidence_rate":1},{"cnt":[[245,1532],[1882,1532],[1882,1583],[245,1583]],"region":{"top_left_x":244,"top_left_y":1531,"width":1639,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af67c6c70a6649f0aaebf3632d4aa7f7","type":"text","conversion_output":true,"text":"Unless otherwise required by law or by regulatory authorities for the purpose of verifying","text_display":"\n\nUnless otherwise required by law or by regulatory authorities for the purpose of verifying","confidence":1,"confidence_rate":1},{"cnt":[[245,1581],[1882,1581],[1882,1631],[245,1631]],"region":{"top_left_x":244,"top_left_y":1581,"width":1639,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"347d1351748245d2a70e956756bb42cb","type":"text","conversion_output":true,"text":"information obtained from this trial, only the Sponsor's authorized personnel and agents will","text_display":" information obtained from this trial, only the Sponsor's authorized personnel and agents will","confidence":1,"confidence_rate":1},{"cnt":[[245,1629],[1880,1629],[1880,1678],[245,1678]],"region":{"top_left_x":244,"top_left_y":1628,"width":1636,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fdee28d442f4674a48b281942984e81","type":"text","conversion_output":true,"text":"have access to the confidential genetic data. The results of the PGt part of the trial may be","text_display":" have access to the confidential genetic data. The results of the PGt part of the trial may be","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[245,1676],[1880,1676],[1880,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1675,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06a3578262944141af652b92fc9fd3c0","type":"text","conversion_output":true,"text":"submitted to the regulatory authorities and governmental agencies in countries where the IMP","text_display":" submitted to the regulatory authorities and governmental agencies in countries where the IMP","confidence":1,"confidence_rate":1},{"cnt":[[245,1723],[1880,1723],[1880,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1723,"width":1636,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b680e3ad0f1c48ddafb2ad0ab2eea413","type":"text","conversion_output":true,"text":"may be considered for approval; however, the subject will be identified by trial number and","text_display":" may be considered for approval; however, the subject will be identified by trial number and","confidence":0.9965834617614746,"confidence_rate":0.9999643507611482},{"cnt":[[245,1770],[1880,1770],[1880,1824],[245,1824]],"region":{"top_left_x":244,"top_left_y":1770,"width":1636,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"269e1c62a34e4e9b850ee06fc7c8bb74","type":"text","conversion_output":true,"text":"subject number only. The subject will not in any case be identifiable in reports or publications","text_display":" subject number only. The subject will not in any case be identifiable in reports or publications","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[245,1818],[649,1818],[649,1869],[245,1869]],"region":{"top_left_x":244,"top_left_y":1817,"width":405,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f45fe9822eb54a82b1e965fea32e1a5b","type":"text","conversion_output":true,"text":"resulting from this trial.","text_display":" resulting from this trial.","confidence":1,"confidence_rate":1},{"cnt":[[236,1908],[1588,1908],[1588,1974],[236,1974]],"region":{"top_left_x":236,"top_left_y":1907,"width":1352,"height":68},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e08e9b4209e4470b32640c7fe17554f","type":"section_header","conversion_output":false,"children_ids":["4fdbbeccef0348729d097900f325115c"],"text":"","text_display":""},{"cnt":[[245,1912],[1583,1912],[1583,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1912,"width":1340,"height":59},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4fdbbeccef0348729d097900f325115c","type":"text","conversion_output":true,"parent_id":"6e08e9b4209e4470b32640c7fe17554f","text":"9.4 Emergency Medical Support and Subject Card","text_display":"\n\n\\subsection*{9.4 Emergency Medical Support and Subject Card}","confidence":0.9785454177763313,"confidence_rate":0.999574833986951},{"cnt":[[245,2007],[1880,2007],[1880,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1636,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1a7a4052b25463f953d4856f0ce306f","type":"text","conversion_output":true,"text":"Subjects enrolled in this clinical trial will be provided with Emergency Medical Support cards","text_display":"\n\nSubjects enrolled in this clinical trial will be provided with Emergency Medical Support cards","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,2054],[1880,2054],[1880,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2053,"width":1636,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a60d81e16084e1a81e5f6f5dffa74af","type":"text","conversion_output":true,"text":"during their trial participation, which will be furnished by the Sponsor. The Emergency Medical","text_display":" during their trial participation, which will be furnished by the Sponsor. The Emergency Medical","confidence":1,"confidence_rate":1},{"cnt":[[245,2101],[1880,2101],[1880,2155],[245,2155]],"region":{"top_left_x":244,"top_left_y":2101,"width":1636,"height":54},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5be1c7f555c45998b4975ae45a1f16b","type":"text","conversion_output":true,"text":"Support card is based on the need to provide clinical trial subjects with a way of identifying","text_display":" Support card is based on the need to provide clinical trial subjects with a way of identifying","confidence":1,"confidence_rate":1},{"cnt":[[245,2151],[1880,2151],[1880,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2150,"width":1636,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"406bb534df8f4d76b5a7700c1d6b0ee3","type":"text","conversion_output":true,"text":"themselves as participating in a clinical trial, and subsequently to give health care providers","text_display":" themselves as participating in a clinical trial, and subsequently to give health care providers","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1884,2196],[1884,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2195,"width":1641,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31c02faa8f2e45eea843d685c41353aa","type":"text","conversion_output":true,"text":"access to the information about this participation that may be needed to determine the course of","text_display":" access to the information about this participation that may be needed to determine the course of","confidence":1,"confidence_rate":1},{"cnt":[[245,2247],[784,2247],[784,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2247,"width":541,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd3988fe864d488b8633c1f0fd0882e3","type":"text","conversion_output":true,"text":"the subject's medical treatment.","text_display":" the subject's medical treatment.","confidence":1,"confidence_rate":1},{"cnt":[[245,2338],[1880,2338],[1880,2387],[245,2387]],"region":{"top_left_x":244,"top_left_y":2337,"width":1636,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f59570f81b344ef81155ad3e4388b8f","type":"text","conversion_output":true,"text":"This service is designed to provide information to health care providers who are not part of the","text_display":"\n\nThis service is designed to provide information to health care providers who are not part of the","confidence":1,"confidence_rate":1},{"cnt":[[245,2385],[1884,2385],[1884,2434],[245,2434]],"region":{"top_left_x":244,"top_left_y":2384,"width":1641,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b52569acc364702b9ba6d450c2152d4","type":"text","conversion_output":true,"text":"clinical trial; and this may include the possibility of emergency unblinding if needed, in case of","text_display":" clinical trial; and this may include the possibility of emergency unblinding if needed, in case of","confidence":1,"confidence_rate":1},{"cnt":[[245,2432],[483,2432],[483,2477],[245,2477]],"region":{"top_left_x":244,"top_left_y":2432,"width":240,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7cc5652371bc4bf6bf187b72db43a598","type":"text","conversion_output":true,"text":"blinded trials.","text_display":" blinded trials.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f9892a8cabf64d298a3a119bf49247fa","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ffca2a275bb043b2b94785634cc34e65","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e35e3be3f29b47e98f0cbc219486d438","type":"page_info","conversion_output":false,"text":"95/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-096","page":96,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3404290810e64d35ac8b057d9663fe42","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b81caafb54e457da83f169baba59db7","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b031b77d44ae41b99ec8de743b44eca3","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"406375fc79f140d88e7fc27f0484fff2","type":"text","conversion_output":true,"text":"Clinical trial Investigators, who are already aware of the clinical trial protocol and treatment,","text_display":"\n\nClinical trial Investigators, who are already aware of the clinical trial protocol and treatment,","confidence":1,"confidence_rate":1},{"cnt":[[245,327],[1884,327],[1884,380],[245,380]],"region":{"top_left_x":244,"top_left_y":326,"width":1641,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00bcc6876f964933968002b918c27e22","type":"text","conversion_output":true,"text":"have other means of accessing the necessary medical information for the management of","text_display":" have other means of accessing the necessary medical information for the management of","confidence":1,"confidence_rate":1},{"cnt":[[245,378],[917,378],[917,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":674,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36661cc601f74e62965ecee4cb745752","type":"text","conversion_output":true,"text":"emergencies occurring in their subjects.","text_display":" emergencies occurring in their subjects.","confidence":1,"confidence_rate":1},{"cnt":[[245,466],[1880,466],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1636,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ee84e98a96c456999e34ab0bfe09046","type":"text","conversion_output":true,"text":"The first point of contact for all emergencies will be the clinical trial Investigator caring for the","text_display":"\n\nThe first point of contact for all emergencies will be the clinical trial Investigator caring for the","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,516],[1880,516],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa293c17328045ebb1e76a1fa0264c89","type":"text","conversion_output":true,"text":"affected subject. The Investigator agrees to provide his or her emergency contact information on","text_display":" affected subject. The Investigator agrees to provide his or her emergency contact information on","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9269ffad90d74e4cb165b5f0674b3b4a","type":"text","conversion_output":true,"text":"the card for this purpose. If the Investigator is available when an event occurs, \\(s / he\\) will answer","text_display":" the card for this purpose. If the Investigator is available when an event occurs, \\(s / he\\) will answer","confidence":0.4065119521692395,"confidence_rate":0.9919952285118241},{"cnt":[[245,610],[1880,610],[1880,660],[245,660]],"region":{"top_left_x":244,"top_left_y":610,"width":1636,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01a5bb6e103a48b2986210450ddaa8de","type":"text","conversion_output":true,"text":"any questions. Any subsequent action (e.g., unblinding) will follow the standard processes","text_display":" any questions. Any subsequent action (e.g., unblinding) will follow the standard processes","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,657],[795,657],[795,707],[245,707]],"region":{"top_left_x":244,"top_left_y":657,"width":551,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1632403a276479c95744cd24aa249f3","type":"text","conversion_output":true,"text":"established for the Investigators.","text_display":" established for the Investigators.","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[1880,748],[1880,797],[245,797]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"447f35b285dc4ea5873550a8cba978ec","type":"text","conversion_output":true,"text":"In cases where the Investigator is not available, Merck Serono/EMD Serono provides the","text_display":"\n\nIn cases where the Investigator is not available, Merck Serono/EMD Serono provides the","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[245,795],[1880,795],[1880,846],[245,846]],"region":{"top_left_x":244,"top_left_y":794,"width":1636,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1921caa4697c407f88407ffde09d6415","type":"text","conversion_output":true,"text":"appropriate means to contact a Sponsor physician. This includes the provision of a 24 -hour","text_display":" appropriate means to contact a Sponsor physician. This includes the provision of a 24 -hour","confidence":0.9912221396807581,"confidence_rate":0.9999109472717227},{"cnt":[[245,842],[1880,842],[1880,896],[245,896]],"region":{"top_left_x":244,"top_left_y":842,"width":1636,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6038fbfe2feb4e15af2494e664806d1f","type":"text","conversion_output":true,"text":"contact number at a call center, whereby the health care providers will be given access to the","text_display":" contact number at a call center, whereby the health care providers will be given access to the","confidence":1,"confidence_rate":1},{"cnt":[[245,889],[1880,889],[1880,943],[245,943]],"region":{"top_left_x":244,"top_left_y":889,"width":1636,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65685034ea0e4a42ae535eee2baba1b7","type":"text","conversion_output":true,"text":"appropriate Sponsor physician to assist with the medical emergency and to provide support for","text_display":" appropriate Sponsor physician to assist with the medical emergency and to provide support for","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[245,939],[1079,939],[1079,990],[245,990]],"region":{"top_left_x":244,"top_left_y":938,"width":835,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db9cecf8c65c4b28af90605881b96d70","type":"text","conversion_output":true,"text":"the potential unblinding of the subject concerned.","text_display":" the potential unblinding of the subject concerned.","confidence":1,"confidence_rate":1},{"cnt":[[236,1023],[1755,1023],[1755,1096],[236,1096]],"region":{"top_left_x":236,"top_left_y":1022,"width":1520,"height":74},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea3e1413480a4afa9896021c7409b4ac","type":"section_header","conversion_output":false,"children_ids":["6f902e6815344432aaf6f11a38d189cc","fea1aaad325a48d39950376483902091"],"text":"","text_display":""},{"cnt":[[245,1031],[316,1031],[316,1081],[245,1081]],"region":{"top_left_x":244,"top_left_y":1031,"width":72,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f902e6815344432aaf6f11a38d189cc","type":"text","conversion_output":true,"parent_id":"ea3e1413480a4afa9896021c7409b4ac","text":"9.5","text_display":"\n\n\\section*{9.5","confidence":1,"confidence_rate":1},{"cnt":[[593,1031],[1747,1031],[1747,1089],[593,1089]],"region":{"top_left_x":592,"top_left_y":1031,"width":1155,"height":59},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fea1aaad325a48d39950376483902091","type":"text","conversion_output":true,"parent_id":"ea3e1413480a4afa9896021c7409b4ac","text":"Clinical Trial Insurance and Compensation to Subjects","text_display":" Clinical Trial Insurance and Compensation to Subjects}","confidence":0.99560546875,"confidence_rate":0.9999240681315057},{"cnt":[[245,1126],[1880,1126],[1880,1177],[245,1177]],"region":{"top_left_x":244,"top_left_y":1125,"width":1636,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ae6666b4e984b6986fc79bf129cb9c1","type":"text","conversion_output":true,"text":"Insurance coverage shall be provided for each country participating to the trial. Insurance","text_display":"\n\nInsurance coverage shall be provided for each country participating to the trial. Insurance","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1210,1173],[1210,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1173,"width":966,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84d8e9e5350c4889a83b9c79e8441eb9","type":"text","conversion_output":true,"text":"conditions shall meet good local standards, as applicable.","text_display":" conditions shall meet good local standards, as applicable.","confidence":1,"confidence_rate":1},{"cnt":[[236,1259],[1888,1259],[1888,1379],[236,1379]],"region":{"top_left_x":236,"top_left_y":1258,"width":1653,"height":122},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ed841712c4d482ba11cbba5506bf6da","type":"section_header","conversion_output":false,"children_ids":["afbadbcb86eb4db992b7d4c3276012e5","bad8fcab49374a89a85ad4042dcebc02"],"text":"","text_display":""},{"cnt":[[245,1265],[1882,1265],[1882,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1265,"width":1639,"height":61},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afbadbcb86eb4db992b7d4c3276012e5","type":"text","conversion_output":true,"parent_id":"1ed841712c4d482ba11cbba5506bf6da","text":"9.6 Independent Ethics Committee or Institutional Review","text_display":"\n\n\\subsection*{9.6 Independent Ethics Committee or Institutional Review","confidence":0.99951171875,"confidence_rate":0.9999919934665097},{"cnt":[[593,1323],[735,1323],[735,1373],[593,1373]],"region":{"top_left_x":592,"top_left_y":1323,"width":143,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bad8fcab49374a89a85ad4042dcebc02","type":"text","conversion_output":true,"parent_id":"1ed841712c4d482ba11cbba5506bf6da","text":"Board","text_display":" Board}","confidence":1,"confidence_rate":1},{"cnt":[[245,1418],[1880,1418],[1880,1467],[245,1467]],"region":{"top_left_x":244,"top_left_y":1417,"width":1636,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ab82fa8c0c54ab3a2782b0a0891bf3d","type":"text","conversion_output":true,"text":"Prior to commencement of the trial at a given site, the clinical trial protocol will be submitted","text_display":"\n\nPrior to commencement of the trial at a given site, the clinical trial protocol will be submitted","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,1465],[1880,1465],[1880,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1465,"width":1636,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b25feb73f054cd3bed5b11f1c9691e6","type":"text","conversion_output":true,"text":"together with its associated documents (the ICF, IB, subject questionnaires, and subject diaries)","text_display":" together with its associated documents (the ICF, IB, subject questionnaires, and subject diaries)","confidence":1,"confidence_rate":1},{"cnt":[[245,1512],[1287,1512],[1287,1566],[245,1566]],"region":{"top_left_x":244,"top_left_y":1512,"width":1043,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd83ed15ca3741449ad00493473c912d","type":"text","conversion_output":true,"text":"to the responsible IEC/IRB for its favorable opinion/approval.","text_display":" to the responsible IEC/IRB for its favorable opinion/approval.","confidence":1,"confidence_rate":1},{"cnt":[[245,1603],[1880,1603],[1880,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":1602,"width":1636,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"535e43496b75411b9149511d4b1bb909","type":"text","conversion_output":true,"text":"The written favorable opinion/approval of the IEC/IRB will be filed in the Investigator Site File,","text_display":"\n\nThe written favorable opinion/approval of the IEC/IRB will be filed in the Investigator Site File,","confidence":0.99462890625,"confidence_rate":0.9999477142802217},{"cnt":[[245,1650],[1880,1650],[1880,1699],[245,1699]],"region":{"top_left_x":244,"top_left_y":1650,"width":1636,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f6874c4de0b41caa1c6550ab96e1d2f","type":"text","conversion_output":true,"text":"and a copy will be filed in the Trial Master File at an external service provider (Trial Master File","text_display":" and a copy will be filed in the Trial Master File at an external service provider (Trial Master File","confidence":0.998046875,"confidence_rate":0.9999813807939509},{"cnt":[[245,1697],[1508,1697],[1508,1749],[245,1749]],"region":{"top_left_x":244,"top_left_y":1697,"width":1265,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bff97010fe2243b28d44f840c425d878","type":"text","conversion_output":true,"text":"documents will be transferred to the Sponsor at the completion of the trial).","text_display":" documents will be transferred to the Sponsor at the completion of the trial).","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1884,1788],[1884,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1787,"width":1641,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3656dac200d44b8b51e79aa912bebd1","type":"text","conversion_output":true,"text":"The trial must not start at a site before the Sponsor has obtained written confirmation of","text_display":"\n\nThe trial must not start at a site before the Sponsor has obtained written confirmation of","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1880,1835],[1880,1886],[245,1886]],"region":{"top_left_x":244,"top_left_y":1834,"width":1636,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e138a2ebe4694412bf1608000a0b26df","type":"text","conversion_output":true,"text":"favorable opinion/approval from the concerned IEC/IRB. The IEC/IRB will be asked to provide","text_display":" favorable opinion/approval from the concerned IEC/IRB. The IEC/IRB will be asked to provide","confidence":1,"confidence_rate":1},{"cnt":[[245,1884],[1880,1884],[1880,1934],[245,1934]],"region":{"top_left_x":244,"top_left_y":1884,"width":1636,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afa1f86f4b6a4e6e9cb789834b7e3976","type":"text","conversion_output":true,"text":"documentation of the date of the meeting at which the favorable opinion/approval was given, and","text_display":" documentation of the date of the meeting at which the favorable opinion/approval was given, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1929],[1880,1929],[1880,1983],[245,1983]],"region":{"top_left_x":244,"top_left_y":1929,"width":1636,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a8d61bb08c449a695b79c4b1eb5efd3","type":"text","conversion_output":true,"text":"of the members and voting members present at the meeting. Written evidence of favorable","text_display":" of the members and voting members present at the meeting. Written evidence of favorable","confidence":1,"confidence_rate":1},{"cnt":[[245,1979],[1880,1979],[1880,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1978,"width":1636,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccf38794f9be4fa9a14d6571e58bc26f","type":"text","conversion_output":true,"text":"opinion/approval that clearly identifies the trial, the clinical trial protocol version and the Subject","text_display":" opinion/approval that clearly identifies the trial, the clinical trial protocol version and the Subject","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,2028],[1880,2028],[1880,2078],[245,2078]],"region":{"top_left_x":244,"top_left_y":2028,"width":1636,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06007c2421934afb8d4a12cd62b34eb5","type":"text","conversion_output":true,"text":"Information and ICF version reviewed should be provided. Where possible, copies of the","text_display":" Information and ICF version reviewed should be provided. Where possible, copies of the","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[866,2075],[866,2125],[245,2125]],"region":{"top_left_x":244,"top_left_y":2075,"width":622,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0e5f5bee82e4bc885acf141e64eda7f","type":"text","conversion_output":true,"text":"meeting minutes should be obtained.","text_display":" meeting minutes should be obtained.","confidence":1,"confidence_rate":1},{"cnt":[[245,2166],[1880,2166],[1880,2215],[245,2215]],"region":{"top_left_x":244,"top_left_y":2165,"width":1636,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb87bb82fe7a46b1a246f8b0468311e1","type":"text","conversion_output":true,"text":"Amendments to the clinical trial will also be submitted to the concerned IEC/IRB, before","text_display":"\n\nAmendments to the clinical trial will also be submitted to the concerned IEC/IRB, before","confidence":1,"confidence_rate":1},{"cnt":[[245,2213],[1880,2213],[1880,2262],[245,2262]],"region":{"top_left_x":244,"top_left_y":2212,"width":1636,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f0a2afa396e4fc2a83b10297623ba9a","type":"text","conversion_output":true,"text":"implementation in case of substantial changes (see Section 10.5). Relevant safety information","text_display":" implementation in case of substantial changes (see Section 10.5). Relevant safety information","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,2260],[1880,2260],[1880,2312],[245,2312]],"region":{"top_left_x":244,"top_left_y":2260,"width":1636,"height":52},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63c548958f7b42b9ab8d2eb7008a9f07","type":"text","conversion_output":true,"text":"will be submitted to the IEC/IRB during the course of the trial in accordance with national","text_display":" will be submitted to the IEC/IRB during the course of the trial in accordance with national","confidence":1,"confidence_rate":1},{"cnt":[[245,2307],[748,2307],[748,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2307,"width":504,"height":55},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d271fc7720ec4bc8b42c245abfe8e1ee","type":"text","conversion_output":true,"text":"regulations and requirements.","text_display":" regulations and requirements.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"46f43c96562040eebee68829fd623c5d","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"83ce2699681b47e69e78e89004fc543a","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79544611078841589472d55884e744ab","type":"page_info","conversion_output":false,"text":"96/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-097","page":97,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96147a312d9a4ee8bcaaf3e1d219c767","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56d06e2a9a054aacb14a84e8077052b6","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67528bb625c74bde93253db269aae292","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,275],[999,275],[999,339],[236,339]],"region":{"top_left_x":236,"top_left_y":275,"width":764,"height":65},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f5d1a5e59b74bcf9c845565ad023e70","type":"section_header","conversion_output":false,"children_ids":["405a163145a449f9be6c7e9b88c5f639"],"text":"","text_display":""},{"cnt":[[243,279],[995,279],[995,333],[243,333]],"region":{"top_left_x":242,"top_left_y":279,"width":753,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"405a163145a449f9be6c7e9b88c5f639","type":"text","conversion_output":true,"parent_id":"5f5d1a5e59b74bcf9c845565ad023e70","text":"9.7 Health Authorities","text_display":"\n\n\\subsection*{9.7 Health Authorities}","confidence":0.99951171875,"confidence_rate":0.9999819112562659},{"cnt":[[245,374],[1882,374],[1882,428],[245,428]],"region":{"top_left_x":244,"top_left_y":373,"width":1639,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a73672fc5f7b466fb06815752a291972","type":"text","conversion_output":true,"text":"The clinical trial protocol and any applicable documentation (e.g., Investigational Medicinal","text_display":"\n\nThe clinical trial protocol and any applicable documentation (e.g., Investigational Medicinal","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1882,425],[1882,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1639,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d109e5a4f08e426ba06b81865d25a3c4","type":"text","conversion_output":true,"text":"Product Dossier, Subject Information and ICF) will be submitted or notified to the Health","text_display":" Product Dossier, Subject Information and ICF) will be submitted or notified to the Health","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1644,473],[1644,526],[245,526]],"region":{"top_left_x":244,"top_left_y":472,"width":1400,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c71275bb187b425fbda523068da3834e","type":"text","conversion_output":true,"text":"Authorities in accordance with the regulations of the countries involved in the trial.","text_display":" Authorities in accordance with the regulations of the countries involved in the trial.","confidence":1,"confidence_rate":1},{"cnt":[[241,561],[312,561],[312,621],[241,621]],"region":{"top_left_x":240,"top_left_y":560,"width":72,"height":61},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e79804178d24e5d9014695ed398948d","type":"section_header","conversion_output":false,"children_ids":["42604a4aba0a457984416f938143defe"],"text":"","text_display":""},{"cnt":[[243,567],[305,567],[305,617],[243,617]],"region":{"top_left_x":242,"top_left_y":567,"width":64,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42604a4aba0a457984416f938143defe","type":"text","conversion_output":true,"parent_id":"7e79804178d24e5d9014695ed398948d","text":"10","text_display":"\n\n\\section*{10}","confidence":0.99755859375,"confidence_rate":0.9987785509060555},{"cnt":[[589,561],[1003,561],[1003,629],[589,629]],"region":{"top_left_x":588,"top_left_y":560,"width":416,"height":70},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"acbdbf72ae5f425a878e3679237ae5e8","type":"section_header","conversion_output":false,"children_ids":["5174b65ff705407b8ce6ee6c7737b5ef"],"text":"","text_display":""},{"cnt":[[593,567],[999,567],[999,625],[593,625]],"region":{"top_left_x":592,"top_left_y":567,"width":408,"height":59},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5174b65ff705407b8ce6ee6c7737b5ef","type":"text","conversion_output":true,"parent_id":"acbdbf72ae5f425a878e3679237ae5e8","text":"Trial Management","text_display":"\n\n\\section*{Trial Management}","confidence":1,"confidence_rate":1},{"cnt":[[241,657],[1205,657],[1205,728],[241,728]],"region":{"top_left_x":240,"top_left_y":657,"width":966,"height":72},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67155c8c2c0848feb2e14986c7513a4a","type":"section_header","conversion_output":false,"children_ids":["dcb1b90e12b34b2887170d3d53ada9c4"],"text":"","text_display":""},{"cnt":[[245,662],[1205,662],[1205,724],[245,724]],"region":{"top_left_x":244,"top_left_y":661,"width":962,"height":64},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dcb1b90e12b34b2887170d3d53ada9c4","type":"text","conversion_output":true,"parent_id":"67155c8c2c0848feb2e14986c7513a4a","text":"10.1 Case Report Form Handling","text_display":"\n\n\\subsection*{10.1 Case Report Form Handling}","confidence":0.9668433666229248,"confidence_rate":0.9990087629144243},{"cnt":[[245,758],[1880,758],[1880,810],[245,810]],"region":{"top_left_x":244,"top_left_y":758,"width":1636,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9b68729ab44436d82fa5aa325645cb5","type":"text","conversion_output":true,"text":"The main purpose of the CRF is to obtain those data required by the clinical trial protocol in a","text_display":"\n\nThe main purpose of the CRF is to obtain those data required by the clinical trial protocol in a","confidence":1,"confidence_rate":1},{"cnt":[[245,808],[1882,808],[1882,857],[245,857]],"region":{"top_left_x":244,"top_left_y":807,"width":1639,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23bfdeebfead4ea4aec11fc55d494dab","type":"text","conversion_output":true,"text":"complete, accurate, legible and timely fashion. The data in the CRF should be consistent with the","text_display":" complete, accurate, legible and timely fashion. The data in the CRF should be consistent with the","confidence":1,"confidence_rate":1},{"cnt":[[245,855],[707,855],[707,900],[245,900]],"region":{"top_left_x":244,"top_left_y":855,"width":463,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5046b52f77894e1cb36706d91e7e85b7","type":"text","conversion_output":true,"text":"relevant source documents.","text_display":" relevant source documents.","confidence":1,"confidence_rate":1},{"cnt":[[245,941],[1882,941],[1882,990],[245,990]],"region":{"top_left_x":244,"top_left_y":941,"width":1639,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f465806d5b94008a59b7c902ce8c357","type":"text","conversion_output":true,"text":"The data collected in the course of this trial must be documented in the CRFs and/or the Adverse","text_display":"\n\nThe data collected in the course of this trial must be documented in the CRFs and/or the Adverse","confidence":1,"confidence_rate":1},{"cnt":[[245,990],[1882,990],[1882,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":990,"width":1639,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd88dd1f5f5a4642a7f4d81067d51788","type":"text","conversion_output":true,"text":"Event Safety Report Form (Clinical Trials). It is the Investigator's responsibility to ensure the","text_display":" Event Safety Report Form (Clinical Trials). It is the Investigator's responsibility to ensure the","confidence":0.99658203125,"confidence_rate":0.999966433667778},{"cnt":[[245,1040],[941,1040],[941,1091],[245,1091]],"region":{"top_left_x":244,"top_left_y":1039,"width":698,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dc2cdc83c5845a79ad6d3272b0686d8","type":"text","conversion_output":true,"text":"accuracy of the data entered in the CRFs.","text_display":" accuracy of the data entered in the CRFs.","confidence":0.9990236759185791,"confidence_rate":0.9999787654211912},{"cnt":[[245,1128],[1880,1128],[1880,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1127,"width":1636,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34fd346bf58d4cc2a1d288606cb37eaf","type":"text","conversion_output":true,"text":"Details regarding CRF handling and instructions concerning CRF completion are provided in the","text_display":"\n\nDetails regarding CRF handling and instructions concerning CRF completion are provided in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[354,1177],[354,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1177,"width":111,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5222f01aa0654fc68568ceb242861505","type":"text","conversion_output":true,"text":"MOP.","text_display":" MOP.","confidence":1,"confidence_rate":1},{"cnt":[[241,1263],[1235,1263],[1235,1334],[241,1334]],"region":{"top_left_x":240,"top_left_y":1263,"width":996,"height":72},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73446d25115c436ea8ca777e28f45bf9","type":"section_header","conversion_output":false,"children_ids":["0a8d7dfa4fe14701ab79961ead03aa07"],"text":"","text_display":""},{"cnt":[[245,1268],[1229,1268],[1229,1330],[245,1330]],"region":{"top_left_x":244,"top_left_y":1267,"width":985,"height":63},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a8d7dfa4fe14701ab79961ead03aa07","type":"text","conversion_output":true,"parent_id":"73446d25115c436ea8ca777e28f45bf9","text":"10.2 Source Data and Subject Files","text_display":"\n\n\\subsection*{10.2 Source Data and Subject Files}","confidence":0.730600118637085,"confidence_rate":0.9917737851147498},{"cnt":[[245,1362],[1882,1362],[1882,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1362,"width":1639,"height":54},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fabc4f4f9bbc4525a2caec1beb03e6a6","type":"text","conversion_output":true,"text":"The Investigator must keep a subject file (medical file, original medical records) on paper or","text_display":"\n\nThe Investigator must keep a subject file (medical file, original medical records) on paper or","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1414],[1880,1414],[1880,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3eec8537dde6418aa3c9ee1c61122b43","type":"text","conversion_output":true,"text":"electronically for every subject included in the trial. This file will contain the available","text_display":" electronically for every subject included in the trial. This file will contain the available","confidence":1,"confidence_rate":1},{"cnt":[[245,1461],[1880,1461],[1880,1510],[245,1510]],"region":{"top_left_x":244,"top_left_y":1460,"width":1636,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"035fe35bbf594d98b4c2e7fc211bee8a","type":"text","conversion_output":true,"text":"demographic and medical information for the subject, and should be as complete as possible. In","text_display":" demographic and medical information for the subject, and should be as complete as possible. In","confidence":1,"confidence_rate":1},{"cnt":[[245,1508],[1261,1508],[1261,1560],[245,1560]],"region":{"top_left_x":244,"top_left_y":1508,"width":1018,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6764076dc1a40a394593028d3d569e7","type":"text","conversion_output":true,"text":"particular, the following data should be available in this file:","text_display":" particular, the following data should be available in this file:","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[638,1577],[638,1631],[245,1631]],"region":{"top_left_x":244,"top_left_y":1576,"width":395,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b314823106ef4e43a1e8b25dc97104e0","type":"text","conversion_output":true,"text":"- Subject's full name,","text_display":"\n- Subject's full name,","confidence":0.99755859375,"confidence_rate":0.9999094710853311},{"cnt":[[245,1652],[526,1652],[526,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1652,"width":283,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f32c8ec572b84d619d99e09643796fc0","type":"text","conversion_output":true,"text":"- Date of birth,","text_display":"\n- Date of birth,","confidence":1,"confidence_rate":1},{"cnt":[[245,1723],[376,1723],[376,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1723,"width":132,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"860f26916eeb46d38251f8259edf147c","type":"text","conversion_output":true,"text":"- Sex,","text_display":"\n- Sex,","confidence":1,"confidence_rate":1},{"cnt":[[245,1796],[428,1796],[428,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1796,"width":184,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ee258fa1de64d8cb2a1af145ea37a89","type":"text","conversion_output":true,"text":"- Height,","text_display":"\n- Height,","confidence":1,"confidence_rate":1},{"cnt":[[245,1867],[436,1867],[436,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1866,"width":193,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8951f6b3bce547558a7e46c47db24145","type":"text","conversion_output":true,"text":"- Weight,","text_display":"\n- Weight,","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1008,1938],[1008,1992],[245,1992]],"region":{"top_left_x":244,"top_left_y":1937,"width":764,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f28f5f274b741f6a8da0748f62287ba","type":"text","conversion_output":true,"text":"- Medical history and concomitant diseases,","text_display":"\n- Medical history and concomitant diseases,","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1880,2011],[1880,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2010,"width":1636,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e6e3d5175544dd7bb031520c38c7e73","type":"text","conversion_output":true,"text":"- Prior and concomitant therapies, including nonpharmacological therapies for OA and the use","text_display":"\n- Prior and concomitant therapies, including nonpharmacological therapies for OA and the use","confidence":0.9755859375,"confidence_rate":0.999745217751677},{"cnt":[[294,2058],[1687,2058],[1687,2110],[294,2110]],"region":{"top_left_x":294,"top_left_y":2058,"width":1393,"height":52},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7032a485468e417f88a108eb9ae4511a","type":"text","conversion_output":true,"text":"of assistive devices for ambulation (e.g., cane) (including changes during the trial),","text_display":" of assistive devices for ambulation (e.g., cane) (including changes during the trial),","confidence":1,"confidence_rate":1},{"cnt":[[245,2127],[965,2127],[965,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2126,"width":721,"height":59},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a821149da6f74c40b875f9ff85a32d07","type":"text","conversion_output":true,"text":"- Trial identification (EMR700692_006),","text_display":"\n- Trial identification (EMR700692_006),","confidence":1,"confidence_rate":1},{"cnt":[[245,2200],[1618,2200],[1618,2254],[245,2254]],"region":{"top_left_x":244,"top_left_y":2200,"width":1374,"height":54},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6458e1301de46acbdb7a721daa55a3c","type":"text","conversion_output":true,"text":"- Date of subject's inclusion into the trial (i.e., date of giving informed consent),","text_display":"\n- Date of subject's inclusion into the trial (i.e., date of giving informed consent),","confidence":0.96923828125,"confidence_rate":0.9996528958874858},{"cnt":[[245,2273],[758,2273],[758,2325],[245,2325]],"region":{"top_left_x":244,"top_left_y":2273,"width":515,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b531c81fb0394ecaa07938873b025bb0","type":"text","conversion_output":true,"text":"- Subject number in the trial,","text_display":"\n- Subject number in the trial,","confidence":1,"confidence_rate":1},{"cnt":[[245,2346],[947,2346],[947,2400],[245,2400]],"region":{"top_left_x":244,"top_left_y":2346,"width":704,"height":54},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00e0af1d9b6541a2a95587eb9a62f362","type":"text","conversion_output":true,"text":"- Dates of the subject's visits to the site,","text_display":"\n- Dates of the subject's visits to the site,","confidence":1,"confidence_rate":1},{"cnt":[[245,2415],[1764,2415],[1764,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2414,"width":1520,"height":55},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93004833960e42b09b70699cc69e7106","type":"text","conversion_output":true,"text":"- Any medical examinations and clinical findings predefined in the clinical trial protocol,","text_display":"\n- Any medical examinations and clinical findings predefined in the clinical trial protocol,","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31aada64c16b489dafb81b12e03a93d3","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[244,2548],[389,2545],[390,2587],[245,2590]],"region":{"top_left_x":244,"top_left_y":2544,"width":146,"height":47},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46f12a8ecd164ac78b0ccb90f8ab0eec","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1506,2529],[1601,2529],[1601,2563],[1506,2563]],"region":{"top_left_x":1506,"top_left_y":2528,"width":95,"height":36},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a36db49f2744491794c64f5439d02b70","type":"page_info","conversion_output":false,"text":"97/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-098","page":98,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2dcd071169e5457e96d0bca7c77c33da","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38016852c7414246a4910ed4e525fc16","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a39a373725f4fc7bcd70962b2756c31","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,284],[561,284],[561,333],[245,333]],"region":{"top_left_x":244,"top_left_y":283,"width":317,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1a7a8dd23a8433681b877056992a0f2","type":"text","conversion_output":true,"text":"- Subject diaries,","text_display":"\n- Subject diaries,","confidence":1,"confidence_rate":1},{"cnt":[[245,354],[844,354],[844,406],[245,406]],"region":{"top_left_x":244,"top_left_y":354,"width":601,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"915494e03053411f95281a2244cf268f","type":"text","conversion_output":true,"text":"- All AEs observed in the subject,","text_display":"\n- All AEs observed in the subject,","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[862,425],[862,479],[245,479]],"region":{"top_left_x":244,"top_left_y":425,"width":618,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f63089306a8c4c0cb54baea638068c92","type":"text","conversion_output":true,"text":"- Date of subject's end of trial, and","text_display":"\n- Date of subject's end of trial, and","confidence":1,"confidence_rate":1},{"cnt":[[245,498],[1886,498],[1886,552],[245,552]],"region":{"top_left_x":244,"top_left_y":498,"width":1643,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87d670d6b7734afeb5b54ac34316bb1d","type":"text","conversion_output":true,"text":"- Date of and reason for early withdrawal of the subject from the trial or from IMP, if","text_display":"\n- Date of and reason for early withdrawal of the subject from the trial or from IMP, if","confidence":1,"confidence_rate":1},{"cnt":[[292,546],[483,546],[483,597],[292,597]],"region":{"top_left_x":292,"top_left_y":545,"width":192,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cd450f761b64673acb8f8ce489186bb","type":"text","conversion_output":true,"text":"applicable.","text_display":" applicable.","confidence":1,"confidence_rate":1},{"cnt":[[245,636],[1394,636],[1394,690],[245,690]],"region":{"top_left_x":244,"top_left_y":635,"width":1151,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29707029bf9b41638a584ef069d6fe8f","type":"text","conversion_output":true,"text":"It must be possible to identify each subject by using this subject file.","text_display":"\n\nIt must be possible to identify each subject by using this subject file.","confidence":1,"confidence_rate":1},{"cnt":[[245,726],[1880,726],[1880,776],[245,776]],"region":{"top_left_x":244,"top_left_y":726,"width":1636,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"426891dd156d4157af7281eaca655f86","type":"text","conversion_output":true,"text":"Additionally, any other documents containing source data must be filed. This includes X-rays,","text_display":"\nAdditionally, any other documents containing source data must be filed. This includes X-rays,","confidence":1,"confidence_rate":1},{"cnt":[[245,773],[1880,773],[1880,823],[245,823]],"region":{"top_left_x":244,"top_left_y":773,"width":1636,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad3c5b7cb71d45548c76d27ed511100f","type":"text","conversion_output":true,"text":"MRI scan images, ECG recordings, and laboratory value listings. Such documents must bear at","text_display":" MRI scan images, ECG recordings, and laboratory value listings. Such documents must bear at","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1880,821],[1880,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1636,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67743c7518c34851a6e49b800c3af383","type":"text","conversion_output":true,"text":"least the subject number and the date when the procedure was performed. Information should be","text_display":" least the subject number and the date when the procedure was performed. Information should be","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1880,868],[1880,922],[245,922]],"region":{"top_left_x":244,"top_left_y":867,"width":1636,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f34c22e3c3494b5a908e40fe2a0b67e3","type":"text","conversion_output":true,"text":"printed by the instrument used to perform the assessment or measurement, if possible.","text_display":" printed by the instrument used to perform the assessment or measurement, if possible.","confidence":1,"confidence_rate":1},{"cnt":[[245,917],[1878,917],[1878,969],[245,969]],"region":{"top_left_x":244,"top_left_y":917,"width":1634,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f5a8c5bb93e4200900aa97041a3936e","type":"text","conversion_output":true,"text":"Information that cannot be printed by an automated instrument will be entered manually.","text_display":" Information that cannot be printed by an automated instrument will be entered manually.","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1880,967],[1880,1016],[245,1016]],"region":{"top_left_x":244,"top_left_y":966,"width":1636,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1cadbb3b7064d329be2b196d4be2004","type":"text","conversion_output":true,"text":"Medical evaluation of such records should be documented as necessary and the documentation","text_display":" Medical evaluation of such records should be documented as necessary and the documentation","confidence":0.9970703125,"confidence_rate":0.9999691163986473},{"cnt":[[245,1014],[866,1014],[866,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1014,"width":622,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"584b6f3cf9774520bb52fae7788e2fb7","type":"text","conversion_output":true,"text":"signed and dated by the Investigator.","text_display":" signed and dated by the Investigator.","confidence":1,"confidence_rate":1},{"cnt":[[245,1104],[1880,1104],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1104,"width":1636,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2302c07977094aaeaf4208029d4366f7","type":"text","conversion_output":true,"text":"Electronic subject files will be printed whenever the Monitor performs source data verification.","text_display":"\n\nElectronic subject files will be printed whenever the Monitor performs source data verification.","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1152],[1880,1152],[1880,1201],[245,1201]],"region":{"top_left_x":244,"top_left_y":1151,"width":1636,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dcafd08447b46b99c5fe62cf72e9372","type":"text","conversion_output":true,"text":"Printouts must be signed and dated by the Investigator, countersigned by the Monitor and kept in","text_display":" Printouts must be signed and dated by the Investigator, countersigned by the Monitor and kept in","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1199],[629,1199],[629,1248],[245,1248]],"region":{"top_left_x":244,"top_left_y":1198,"width":386,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d72c8ed2abe74fe790ef59a1aec25b3d","type":"text","conversion_output":true,"text":"a safe place at the site.","text_display":" a safe place at the site.","confidence":0.99853515625,"confidence_rate":0.9999511372710721},{"cnt":[[243,1285],[1354,1285],[1354,1356],[243,1356]],"region":{"top_left_x":242,"top_left_y":1284,"width":1112,"height":72},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"baeb2fa0880742b2b3194f3c9fb819cd","type":"section_header","conversion_output":false,"children_ids":["65f2b9ec176f4f4c94e65c4562d31ae6"],"text":"","text_display":""},{"cnt":[[249,1291],[1347,1291],[1347,1349],[249,1349]],"region":{"top_left_x":249,"top_left_y":1291,"width":1099,"height":59},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65f2b9ec176f4f4c94e65c4562d31ae6","type":"text","conversion_output":true,"parent_id":"baeb2fa0880742b2b3194f3c9fb819cd","text":"10.3 Investigator Site File and Archiving","text_display":"\n\n\\subsection*{10.3 Investigator Site File and Archiving}","confidence":0.98828125,"confidence_rate":0.9997437729241124},{"cnt":[[245,1388],[1880,1388],[1880,1437],[245,1437]],"region":{"top_left_x":244,"top_left_y":1387,"width":1636,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c2a18d3b8e44e9b9b46627e3dd03585","type":"text","conversion_output":true,"text":"The Investigator will be provided with an Investigator Site File upon initiation of the trial. This","text_display":"\n\nThe Investigator will be provided with an Investigator Site File upon initiation of the trial. This","confidence":1,"confidence_rate":1},{"cnt":[[245,1435],[1880,1435],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1435,"width":1636,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf69bd9a885b4a2a851bca4514aa4f78","type":"text","conversion_output":true,"text":"file will contain all documents necessary for the conduct of the trial and will be updated and","text_display":" file will contain all documents necessary for the conduct of the trial and will be updated and","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1482],[1880,1482],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1482,"width":1636,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"febcc67c43614c628aaac1ae6da5e407","type":"text","conversion_output":true,"text":"completed throughout the trial. It must be available for review by the Monitor, and must be ready","text_display":" completed throughout the trial. It must be available for review by the Monitor, and must be ready","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1880,1530],[1880,1579],[245,1579]],"region":{"top_left_x":244,"top_left_y":1529,"width":1636,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"621fa7c356884102bc507d47feb641cb","type":"text","conversion_output":true,"text":"for Sponsor audit as well as for inspection by Health Authorities during and after the trial, and","text_display":" for Sponsor audit as well as for inspection by Health Authorities during and after the trial, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1880,1577],[1880,1626],[245,1626]],"region":{"top_left_x":244,"top_left_y":1576,"width":1636,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71893cfb047047e5a4b22179d06baebb","type":"text","conversion_output":true,"text":"must be safely archived for at least 15 years (or per local requirements or as otherwise notified","text_display":" must be safely archived for at least 15 years (or per local requirements or as otherwise notified","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,1624],[1880,1624],[1880,1676],[245,1676]],"region":{"top_left_x":244,"top_left_y":1624,"width":1636,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c46fcb93608249589508564b6781a7ee","type":"text","conversion_output":true,"text":"by the Sponsor) after the end of the trial. The documents to be thus archived include the Subject","text_display":" by the Sponsor) after the end of the trial. The documents to be thus archived include the Subject","confidence":0.9970715045928955,"confidence_rate":0.9999712475521841},{"cnt":[[245,1674],[1880,1674],[1880,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1673,"width":1636,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85f6835fb4ce4c98896faf1a76ae6df2","type":"text","conversion_output":true,"text":"Identification List and the signed subject ICFs. If archiving of the Investigator Site File is no","text_display":" Identification List and the signed subject ICFs. If archiving of the Investigator Site File is no","confidence":1,"confidence_rate":1},{"cnt":[[245,1721],[1377,1721],[1377,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1720,"width":1134,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3833f0432484759b798119b3363d13f","type":"text","conversion_output":true,"text":"longer possible at the site, the Investigator must notify the Sponsor.","text_display":" longer possible at the site, the Investigator must notify the Sponsor.","confidence":1,"confidence_rate":1},{"cnt":[[245,1811],[1880,1811],[1880,1863],[245,1863]],"region":{"top_left_x":244,"top_left_y":1811,"width":1636,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f30d3eeeab104f8abe401dc4281ad594","type":"text","conversion_output":true,"text":"All original subject files (medical records) must be stored at the site (hospital, research institute,","text_display":"\n\nAll original subject files (medical records) must be stored at the site (hospital, research institute,","confidence":1,"confidence_rate":1},{"cnt":[[245,1861],[1880,1861],[1880,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1860,"width":1636,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"920f0d605c514b48a1743ec1bb54a1af","type":"text","conversion_output":true,"text":"or practice) for the longest possible time permitted by the applicable regulations, and/or as per","text_display":" or practice) for the longest possible time permitted by the applicable regulations, and/or as per","confidence":1,"confidence_rate":1},{"cnt":[[245,1908],[1880,1908],[1880,1957],[245,1957]],"region":{"top_left_x":244,"top_left_y":1907,"width":1636,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7a6ab5db119484392a36265bb0aab50","type":"text","conversion_output":true,"text":"ICH GCP guidelines, whichever is longer. In any case, the Investigator should ensure that no","text_display":" ICH GCP guidelines, whichever is longer. In any case, the Investigator should ensure that no","confidence":1,"confidence_rate":1},{"cnt":[[245,1955],[1729,1955],[1729,2004],[245,2004]],"region":{"top_left_x":244,"top_left_y":1955,"width":1486,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"772ba95c1d674b9895f7b374131294a7","type":"text","conversion_output":true,"text":"destruction of medical records is performed without the written approval of the Sponsor.","text_display":" destruction of medical records is performed without the written approval of the Sponsor.","confidence":1,"confidence_rate":1},{"cnt":[[241,2041],[1886,2041],[1886,2159],[241,2159]],"region":{"top_left_x":240,"top_left_y":2041,"width":1647,"height":119},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b5d2b8c8f214a0abc9181e5814314fb","type":"section_header","conversion_output":false,"children_ids":["bdfae4a4bff94f8e8cd0a2c51914b870","eb0906f0e10d4c29b4284bb1c9100052"],"text":"","text_display":""},{"cnt":[[245,2045],[1880,2045],[1880,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2045,"width":1636,"height":59},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdfae4a4bff94f8e8cd0a2c51914b870","type":"text","conversion_output":true,"parent_id":"0b5d2b8c8f214a0abc9181e5814314fb","text":"10.4 Monitoring, Quality Assurance and Inspection by Health","text_display":"\n\n\\subsection*{10.4 Monitoring, Quality Assurance and Inspection by Health","confidence":0.9052734375,"confidence_rate":0.998446235842819},{"cnt":[[593,2105],[840,2105],[840,2151],[593,2151]],"region":{"top_left_x":592,"top_left_y":2105,"width":249,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb0906f0e10d4c29b4284bb1c9100052","type":"text","conversion_output":true,"parent_id":"0b5d2b8c8f214a0abc9181e5814314fb","text":"Authorities","text_display":" Authorities}","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1880,2196],[1880,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2195,"width":1636,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"796ebcf7611c4ecfb9d201a3a838a65f","type":"text","conversion_output":true,"text":"This trial will be monitored in accordance with the ICH Note for Guidance on Good Clinical","text_display":"\n\nThis trial will be monitored in accordance with the ICH Note for Guidance on Good Clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,2243],[1880,2243],[1880,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2242,"width":1636,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b96fe2ce0b7445a9ea15cf4157e53f6","type":"text","conversion_output":true,"text":"Practice (ICH Topic E6, 1996). The site Monitor will perform visits to the trial site at regular","text_display":" Practice (ICH Topic E6, 1996). The site Monitor will perform visits to the trial site at regular","confidence":1,"confidence_rate":1},{"cnt":[[245,2295],[406,2295],[406,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2294,"width":163,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3763ef996018467e8f3fda72b6a5c419","type":"text","conversion_output":true,"text":"intervals.","text_display":" intervals.","confidence":1,"confidence_rate":1},{"cnt":[[245,2385],[1880,2385],[1880,2434],[245,2434]],"region":{"top_left_x":244,"top_left_y":2384,"width":1636,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c56b1eaab604438bb5d345647ef23f53","type":"text","conversion_output":true,"text":"Representatives of the Sponsor's Quality Assurance unit or a designated organization, as well as","text_display":"\n\nRepresentatives of the Sponsor's Quality Assurance unit or a designated organization, as well as","confidence":1,"confidence_rate":1},{"cnt":[[245,2432],[1882,2432],[1882,2481],[245,2481]],"region":{"top_left_x":244,"top_left_y":2432,"width":1639,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"633f7372168d411fb5545df6b42ea3b1","type":"text","conversion_output":true,"text":"Health Authorities, must be permitted to inspect all trial-related documents and other materials at","text_display":" Health Authorities, must be permitted to inspect all trial-related documents and other materials at","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"33cbe2b0e37a4048b3854d7964eaaf30","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"19eb76b59a864cab99a718deedc7f8aa","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1504e54a89154c28b838e9358bd4087b","type":"page_info","conversion_output":false,"text":"98/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-099","page":99,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60a27defc0f445788ee75fb6e0bcffb8","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df1584034b1c40c0995f2161e15d23e4","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b70fe518a744e50a986a9a55434f2c9","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1880,279],[1880,331],[245,331]],"region":{"top_left_x":244,"top_left_y":279,"width":1636,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de1556cfdae046c0baea94f0994a9e69","type":"text","conversion_output":true,"text":"the site, including the Investigator Site File, the completed CRFs, the IMP(s), and the subjects'","text_display":"\nthe site, including the Investigator Site File, the completed CRFs, the IMP(s), and the subjects'","confidence":0.9883134234696627,"confidence_rate":0.9998847576084765},{"cnt":[[245,329],[752,329],[752,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":508,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15a7f60365c341cd863f537746ec637e","type":"text","conversion_output":true,"text":"original medical records/files.","text_display":" original medical records/files.","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1880,417],[1880,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1636,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f11f597e85c4a559262c7e5d0f5979a","type":"text","conversion_output":true,"text":"The clinical trial protocol, each step of the data capture procedure, and the handling of the data,","text_display":"\n\nThe clinical trial protocol, each step of the data capture procedure, and the handling of the data,","confidence":1,"confidence_rate":1},{"cnt":[[245,466],[1880,466],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":466,"width":1636,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"944c37d51b13406db174924cdf2efb34","type":"text","conversion_output":true,"text":"including the final clinical trial report, will be subject to independent Quality Assurance","text_display":" including the final clinical trial report, will be subject to independent Quality Assurance","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1880,516],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9f14d8feba744508e7bc2fe024f1d2f","type":"text","conversion_output":true,"text":"activities. Audits may be conducted at any time during or after the trial to ensure the validity and","text_display":" activities. Audits may be conducted at any time during or after the trial to ensure the validity and","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[668,563],[668,612],[245,612]],"region":{"top_left_x":244,"top_left_y":562,"width":425,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70caf376bb5e484ea0d00b8b7e6b2bf1","type":"text","conversion_output":true,"text":"integrity of the trial data.","text_display":" integrity of the trial data.","confidence":1,"confidence_rate":1},{"cnt":[[241,649],[1401,649],[1401,715],[241,715]],"region":{"top_left_x":240,"top_left_y":648,"width":1161,"height":68},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fc103df26c54639a53830e9c00bb8af","type":"section_header","conversion_output":false,"children_ids":["60e6d38e200d43bc91510a8f81c22a82"],"text":"","text_display":""},{"cnt":[[245,653],[1394,653],[1394,711],[245,711]],"region":{"top_left_x":244,"top_left_y":653,"width":1151,"height":59},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60e6d38e200d43bc91510a8f81c22a82","type":"text","conversion_output":true,"parent_id":"5fc103df26c54639a53830e9c00bb8af","text":"10.5 Changes to the Clinical Trial Protocol","text_display":"\n\n\\subsection*{10.5 Changes to the Clinical Trial Protocol}","confidence":0.9941432476043701,"confidence_rate":0.9998776331034666},{"cnt":[[245,748],[1880,748],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e61187d85e242a3a691001877678d95","type":"text","conversion_output":true,"text":"Changes to the clinical trial protocol will be documented in written protocol amendments. Major","text_display":"\n\nChanges to the clinical trial protocol will be documented in written protocol amendments. Major","confidence":1,"confidence_rate":1},{"cnt":[[245,797],[1880,797],[1880,849],[245,849]],"region":{"top_left_x":244,"top_left_y":797,"width":1636,"height":52},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a86494543c1d4ceeafc0025bb332571a","type":"text","conversion_output":true,"text":"(substantial, significant) amendments will usually require submission to the Health Authorities","text_display":" (substantial, significant) amendments will usually require submission to the Health Authorities","confidence":1,"confidence_rate":1},{"cnt":[[245,846],[1880,846],[1880,896],[245,896]],"region":{"top_left_x":244,"top_left_y":846,"width":1636,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"521a540cce2a46029045b689c43d4790","type":"text","conversion_output":true,"text":"and to the relevant IEC/IRB for approval or favorable opinion. In such cases, the amendment","text_display":" and to the relevant IEC/IRB for approval or favorable opinion. In such cases, the amendment","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,894],[1592,894],[1592,943],[245,943]],"region":{"top_left_x":244,"top_left_y":893,"width":1348,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"842e0dc8eb65400fa474176ab7a5aa86","type":"text","conversion_output":true,"text":"will be implemented only after approval or favorable opinion has been obtained.","text_display":" will be implemented only after approval or favorable opinion has been obtained.","confidence":1,"confidence_rate":1},{"cnt":[[245,982],[1880,982],[1880,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":981,"width":1636,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"170ee704fd664c74b1ebad6f38710edd","type":"text","conversion_output":true,"text":"Minor (nonsubstantial) protocol amendments, including administrative changes, will be filed by","text_display":"\n\nMinor (nonsubstantial) protocol amendments, including administrative changes, will be filed by","confidence":1,"confidence_rate":1},{"cnt":[[245,1031],[1880,1031],[1880,1081],[245,1081]],"region":{"top_left_x":244,"top_left_y":1031,"width":1636,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc6e54f1d8de45788ae09d1a38b4a517","type":"text","conversion_output":true,"text":"the Sponsor and at the site. They will be submitted to the relevant IEC/IRB or to Health","text_display":" the Sponsor and at the site. They will be submitted to the relevant IEC/IRB or to Health","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1222,1079],[1222,1130],[245,1130]],"region":{"top_left_x":244,"top_left_y":1078,"width":979,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b15e5875a2164810a31f6d6a8c24b343","type":"text","conversion_output":true,"text":"Authorities only where requested by pertinent regulations.","text_display":" Authorities only where requested by pertinent regulations.","confidence":1,"confidence_rate":1},{"cnt":[[245,1169],[1880,1169],[1880,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1168,"width":1636,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e884651b4db4ab9adae4122da79b2a0","type":"text","conversion_output":true,"text":"Any amendment that could have an impact on the subject's agreement to participate in the trial","text_display":"\n\nAny amendment that could have an impact on the subject's agreement to participate in the trial","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1613,1216],[1613,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1370,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29eb6312a6b5441e858576efb480a787","type":"text","conversion_output":true,"text":"requires the subject's informed consent prior to implementation (see Section 9.2).","text_display":" requires the subject's informed consent prior to implementation (see Section 9.2).","confidence":1,"confidence_rate":1},{"cnt":[[243,1302],[1528,1302],[1528,1371],[243,1371]],"region":{"top_left_x":242,"top_left_y":1301,"width":1286,"height":70},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3e5f21ebda345ceb1729fb98d3910a0","type":"section_header","conversion_output":false,"children_ids":["6087fadaa8a44f068e6c0189d265a455"],"text":"","text_display":""},{"cnt":[[247,1308],[1523,1308],[1523,1364],[247,1364]],"region":{"top_left_x":247,"top_left_y":1308,"width":1277,"height":57},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6087fadaa8a44f068e6c0189d265a455","type":"text","conversion_output":true,"parent_id":"a3e5f21ebda345ceb1729fb98d3910a0","text":"10.6 Clinical Trial Report and Publication Policy","text_display":"\n\n\\subsection*{10.6 Clinical Trial Report and Publication Policy}","confidence":0.9794921875,"confidence_rate":0.9996163510632385},{"cnt":[[245,1401],[1068,1401],[1068,1467],[245,1467]],"region":{"top_left_x":244,"top_left_y":1400,"width":824,"height":68},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"883a95d4cbc641cfbb4c4960ac0688a7","type":"section_header","conversion_output":false,"children_ids":["622b497abe9e4864a77cbd24664fe3e2"],"text":"","text_display":""},{"cnt":[[249,1405],[1059,1405],[1059,1463],[249,1463]],"region":{"top_left_x":249,"top_left_y":1405,"width":811,"height":59},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"622b497abe9e4864a77cbd24664fe3e2","type":"text","conversion_output":true,"parent_id":"883a95d4cbc641cfbb4c4960ac0688a7","text":"10.6.1 Clinical Trial Reports","text_display":"\n\n\\subsection*{10.6.1 Clinical Trial Reports}","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1551],[245,1551]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"336c3141bf47464f9036f4f9daa3adc4","type":"text","conversion_output":true,"text":"Clinical Trial Reports according to ICH Topic E3 will be written by the Sponsor in consultation","text_display":"\n\nClinical Trial Reports according to ICH Topic E3 will be written by the Sponsor in consultation","confidence":0.9897553898626938,"confidence_rate":0.9998970308283911},{"cnt":[[245,1549],[838,1549],[838,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1549,"width":594,"height":52},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"374594f2c3b9459983cf49a83c258665","type":"text","conversion_output":true,"text":"with the Coordinating Investigator.","text_display":" with the Coordinating Investigator.","confidence":1,"confidence_rate":1},{"cnt":[[245,1637],[1880,1637],[1880,1689],[245,1689]],"region":{"top_left_x":244,"top_left_y":1637,"width":1636,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0c9f14dc8a646a7a17414bbb6e860a0","type":"text","conversion_output":true,"text":"It is planned to perform the statistical analysis in two steps, as described in Section 8.5.1. A","text_display":"\n\nIt is planned to perform the statistical analysis in two steps, as described in Section 8.5.1. A","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1687],[1880,1687],[1880,1738],[245,1738]],"region":{"top_left_x":244,"top_left_y":1686,"width":1636,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c736e83daa10457585c9668cf85cff20","type":"text","conversion_output":true,"text":"detailed Clinical Trial Report will be written based on the data collected up to the end of the","text_display":" detailed Clinical Trial Report will be written based on the data collected up to the end of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1732],[1880,1732],[1880,1783],[245,1783]],"region":{"top_left_x":244,"top_left_y":1731,"width":1636,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0db243e36384df9b08feeea524007ae","type":"text","conversion_output":true,"text":"DBPC treatment phase, and long-term follow-up data will be analyzed and reported separately","text_display":" DBPC treatment phase, and long-term follow-up data will be analyzed and reported separately","confidence":1,"confidence_rate":1},{"cnt":[[245,1783],[917,1783],[917,1833],[245,1833]],"region":{"top_left_x":244,"top_left_y":1783,"width":674,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b55aca00a98944f99a1556e2df5e19fe","type":"text","conversion_output":true,"text":"from the DBPC treatment phase results.","text_display":" from the DBPC treatment phase results.","confidence":1,"confidence_rate":1},{"cnt":[[243,1869],[849,1869],[849,1927],[243,1927]],"region":{"top_left_x":242,"top_left_y":1869,"width":607,"height":59},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18e88999f4894c4a953561b8d5941753","type":"section_header","conversion_output":false,"children_ids":["770f34e416564bfc96abbc0e7d825205"],"text":"","text_display":""},{"cnt":[[249,1873],[844,1873],[844,1923],[249,1923]],"region":{"top_left_x":249,"top_left_y":1873,"width":596,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"770f34e416564bfc96abbc0e7d825205","type":"text","conversion_output":true,"parent_id":"18e88999f4894c4a953561b8d5941753","text":"10.6.2 Publication","text_display":"\n\n\\subsection*{10.6.2 Publication}","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1880,1968],[1880,2020],[245,2020]],"region":{"top_left_x":244,"top_left_y":1967,"width":1636,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"689f3c57cf7b4cff91b15015534d56d1","type":"text","conversion_output":true,"text":"The first publication will be a publication of the results of the analysis of the primary endpoint","text_display":"\n\nThe first publication will be a publication of the results of the analysis of the primary endpoint","confidence":0.9970703125,"confidence_rate":0.9999715150908018},{"cnt":[[245,2015],[922,2015],[922,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2015,"width":678,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4f8bb0820fd4d4198626ed63e39305f","type":"text","conversion_output":true,"text":"that will include data from all trial sites.","text_display":" that will include data from all trial sites.","confidence":0.9951193332672119,"confidence_rate":0.9999001556769588},{"cnt":[[245,2105],[1882,2105],[1882,2157],[245,2157]],"region":{"top_left_x":244,"top_left_y":2105,"width":1639,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6e2a3467b3345db8562424e858f9156","type":"text","conversion_output":true,"text":"The Investigator will inform the Sponsor in advance about any plans to publish or present data","text_display":"\n\nThe Investigator will inform the Sponsor in advance about any plans to publish or present data","confidence":1,"confidence_rate":1},{"cnt":[[245,2155],[1880,2155],[1880,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2154,"width":1636,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b075ee7162844e5a9ab2771f9790ccaa","type":"text","conversion_output":true,"text":"from the trial. Any publications and presentations of the results (abstracts in journals or","text_display":" from the trial. Any publications and presentations of the results (abstracts in journals or","confidence":0.9990234375,"confidence_rate":0.999989822555459},{"cnt":[[245,2202],[1882,2202],[1882,2254],[245,2254]],"region":{"top_left_x":244,"top_left_y":2202,"width":1639,"height":52},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aee0a0a513314848a5a148a94329ce29","type":"text","conversion_output":true,"text":"newspapers, oral presentations, etc.), either in whole or in part, by Investigators or their","text_display":" newspapers, oral presentations, etc.), either in whole or in part, by Investigators or their","confidence":1,"confidence_rate":1},{"cnt":[[245,2252],[1366,2252],[1366,2301],[245,2301]],"region":{"top_left_x":244,"top_left_y":2251,"width":1123,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"513d7050d049499e89499a0e0a0927e9","type":"text","conversion_output":true,"text":"representatives will require pre-submission review by the Sponsor.","text_display":" representatives will require pre-submission review by the Sponsor.","confidence":1,"confidence_rate":1},{"cnt":[[245,2340],[1880,2340],[1880,2391],[245,2391]],"region":{"top_left_x":244,"top_left_y":2339,"width":1636,"height":53},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd454bd4d9c643f7b4b3e53b9997923f","type":"text","conversion_output":true,"text":"The Sponsor will not suppress or veto publications, but maintains the right to delay publication","text_display":"\n\nThe Sponsor will not suppress or veto publications, but maintains the right to delay publication","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[245,2389],[1016,2389],[1016,2438],[245,2438]],"region":{"top_left_x":244,"top_left_y":2389,"width":773,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4be114fb13f49eda1ced3aeff3b7334","type":"text","conversion_output":true,"text":"in order to protect intellectual property rights.","text_display":" in order to protect intellectual property rights.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b0778eb6d77748dd83e79486f8ecc8f7","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5d7870567a444644a0817266e9381ec2","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1508,2531],[1601,2531],[1601,2563],[1508,2563]],"region":{"top_left_x":1508,"top_left_y":2530,"width":93,"height":34},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c883620f78144eab82cac042cd256bbd","type":"page_info","conversion_output":false,"text":"99/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1904,2501],[1904,2608],[1796,2608]],"region":{"top_left_x":1796,"top_left_y":2500,"width":108,"height":109},"line":44,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"08c53bcab3404086b888b094cf27ba71","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999186032298787}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-100","page":100,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1b37d345740414e9a35b0a15d585d77","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28c5ca3aff2549d59a51783b781d4d55","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bccc4ae6d5f34157a168a33e080314af","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[239,319],[1869,319],[1869,2469],[239,2469]],"region":{"top_left_x":239,"top_left_y":319,"width":1630,"height":2150},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec90ae1f6f81436bbcee74b96e9ca438","type":"column","conversion_output":false,"children_ids":["d823ca2d233b4d25b73c66e54910e744","78fdb120e7dd48d8bc8642f88ac8257d","3605c195fa584f9cbf1ad19cb6f64632","b9ef5728c1c143e2860798c2cbd86b60","6087405592064d779f34fa3365ff70be","e1a63a72d3494ad4b2440640ffb19739","07ea8cc8f0a74bfaae8a1fe48156fa38","5e65eb546b114078b41fda9281bc105b","33cca6391bfc410d8c0c5a588f063965","bfe970781d9c4aec9c3a9233cfd53cdb","76d4b6877cb04b9fa98de348737be88f","3b70a9c7f14a4b56ba619f81a63ebe8d","6fd89f9249704be19774c9eb7413f0a5","540d0d1c416e4c57a2206aef87d3d4cd","2c223f9d7a564ff5ac1e5bb6c2364a54","48ded09bdd6c45a2a06f680ba6342bbd","1d0d3ffb4a214f348035d303b174fb9d","e24429376b6f453bbb103c7dcdde2180","d43658fb1b61453793b653d64f68cc8b","8759d905e5d54a52ace6731d97bd7994","74eb37e0953f4d74a0794f05f9707b4f","c35237210ac14cd5935151da83329e69","b0bff73a70224c998e7b391851327686","6c7c5b7377dd4816b19a1b050c4eeeea","d5143d22ad6b49969a28310dcc5b1de3","1b163f201b8c4e6184d2071126241bd2","9641d334ed644c86ac551e37459a1cb3","8ea9c659ec05415da0e0c544632bd766","5d76b901b05341a48488117bb3fe2cdf","1ee9fcdacf774f888e5e1af9cfc61878","b6d06e11257f41149f210edf89d59df8","d73a46b8414b4f69b04391792e3ab13e","f823c809fae6404a98b25c6cb724efff","8f3a4aa506e94397a6436000affc0965","00e51848924c4e5bad8739d0300e03d6","44fb79fc2a1444e6a9c8f2344a5bf07a","83edfd54b5ca4d3ab67274d522f1c978","fdc2de8cff004f6b980df4a5692b505c","d8c278329d424e25adaaddebdf6cdb15","39f702eb898d4fef9856615cbf290c3a","7b9838e176cb4a94846b128028771ca7","0369a8c3968b48edbe8c71cf4b4cc2fa","9558c01d3fa34d09b4bf7937a377e1cc","69cc626f1b294e619489cd95ba3c9705","36c5a35b78a44fd383d94d06c25849a3","cb70279fbfde4b7dad9a5fdbafc12e7c","806d495dfee74d15bf2f3b69ea3dbd25","1668b2dbb2bd47eaa38b451649c7c39e","fea95e860e524122944c57d728f15dd5","c5290bfae7a2445fa0fbec35a0948c1a","25c20a76f62f4cab854ef26c50772dd1","bd52aba62eb349b78fedba46e9049a36","c441a17e36ab41259133e75fff6171ba","4c9eb4aeb8b84e3683c3bf48848f986d","24d692276858488c9bcc9eebe7c34984","45458bad867145e588fd37f2f29c38e2","ebf7ba0bdfd242ac974fb9b54f9aef09","03ba0eabad8245f395985f2b14b17d29","55af3b351ef9488cb6f8d0176713c16a","18e41c7b52034c028671b74ffef921e8","49d0471efa8e4456bbd4918002d33c8c","1f7046b101414d48919a6ef75b7014cd","dbecaf1c970e4aa1b10d28deda7db6cb","0fd870ffacaa4d02b433af7bd8e5dde8","36e7396e9eff4f5db2288869856fb764","4452dc776b9046a7bca292571edc0cc1","c5beb06950624ff589b79a5abbefae71","fef9511c7ba547e4909ff5f4d754e4a0"],"text":"","text_display":""},{"cnt":[[245,322],[303,322],[303,374],[245,374]],"region":{"top_left_x":244,"top_left_y":322,"width":59,"height":52},"line":5,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d823ca2d233b4d25b73c66e54910e744","type":"page_info","conversion_output":false,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"11","text_display":"","confidence":0.99951171875,"confidence_rate":0.9997558295653994},{"cnt":[[247,438],[1863,438],[1863,492],[247,492]],"region":{"top_left_x":247,"top_left_y":438,"width":1616,"height":54},"line":6,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78fdb120e7dd48d8bc8642f88ac8257d","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"1. Pham T, van der Heijde D, Altman RD, Anderson JJ, Bellamy N, Hochberg M, et al.","text_display":"\n1. Pham T, van der Heijde D, Altman RD, Anderson JJ, Bellamy N, Hochberg M, et al.","confidence":1,"confidence_rate":1},{"cnt":[[387,490],[1865,490],[1865,539],[387,539]],"region":{"top_left_x":386,"top_left_y":489,"width":1479,"height":51},"line":7,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3605c195fa584f9cbf1ad19cb6f64632","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"OMERACT-OARSI initiative: Osteoarthritis Research Society International set of","text_display":" OMERACT-OARSI initiative: Osteoarthritis Research Society International set of","confidence":1,"confidence_rate":1},{"cnt":[[387,537],[1863,537],[1863,587],[387,587]],"region":{"top_left_x":386,"top_left_y":537,"width":1477,"height":50},"line":8,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9ef5728c1c143e2860798c2cbd86b60","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"responder criteria for osteoarthritis clinical trials revisited. Osteoarthritis Cartilage","text_display":" responder criteria for osteoarthritis clinical trials revisited. Osteoarthritis Cartilage","confidence":1,"confidence_rate":1},{"cnt":[[387,584],[675,584],[675,632],[387,632]],"region":{"top_left_x":386,"top_left_y":584,"width":289,"height":48},"line":9,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6087405592064d779f34fa3365ff70be","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"2004;12:389-99.","text_display":" 2004;12:389-99.","confidence":1,"confidence_rate":1},{"cnt":[[245,653],[1861,653],[1861,703],[245,703]],"region":{"top_left_x":244,"top_left_y":653,"width":1617,"height":50},"line":10,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1a63a72d3494ad4b2440640ffb19739","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"2. Hoorman J, Bolen J, Helmick C, Langmaid G. Prevalence of doctor-diagnosed arthritis","text_display":"\n2. Hoorman J, Bolen J, Helmick C, Langmaid G. Prevalence of doctor-diagnosed arthritis","confidence":1,"confidence_rate":1},{"cnt":[[387,700],[1863,700],[1863,750],[387,750]],"region":{"top_left_x":386,"top_left_y":700,"width":1477,"height":50},"line":11,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07ea8cc8f0a74bfaae8a1fe48156fa38","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"and arthritis-attributable activity limitation-United States, 2003-2005. MMWR","text_display":" and arthritis-attributable activity limitation-United States, 2003-2005. MMWR","confidence":1,"confidence_rate":1},{"cnt":[[387,748],[763,748],[763,797],[387,797]],"region":{"top_left_x":386,"top_left_y":747,"width":377,"height":51},"line":12,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e65eb546b114078b41fda9281bc105b","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"2006;55(40):1089-92.","text_display":" 2006;55(40):1089-92.","confidence":0.998046875,"confidence_rate":0.9999218016642171},{"cnt":[[245,816],[1863,816],[1863,866],[245,866]],"region":{"top_left_x":244,"top_left_y":816,"width":1619,"height":50},"line":13,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33cca6391bfc410d8c0c5a588f063965","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"3. Felson DT, Anderson JJ, Naimark A, Swift M, Castelli W, Meenan RF. Obesity and","text_display":"\n3. Felson DT, Anderson JJ, Naimark A, Swift M, Castelli W, Meenan RF. Obesity and","confidence":1,"confidence_rate":1},{"cnt":[[387,866],[1861,866],[1861,915],[387,915]],"region":{"top_left_x":386,"top_left_y":865,"width":1475,"height":51},"line":14,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfe970781d9c4aec9c3a9233cfd53cdb","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"symptomatic knee osteoarthritis. Results from the Framingham Study. Arthritis Rheum","text_display":" symptomatic knee osteoarthritis. Results from the Framingham Study. Arthritis Rheum","confidence":1,"confidence_rate":1},{"cnt":[[391,913],[797,913],[797,965],[391,965]],"region":{"top_left_x":391,"top_left_y":913,"width":407,"height":52},"line":15,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76d4b6877cb04b9fa98de348737be88f","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"1987;30(Suppl 4):S130.","text_display":" 1987;30(Suppl 4):S130.","confidence":1,"confidence_rate":1},{"cnt":[[243,982],[1861,982],[1861,1033],[243,1033]],"region":{"top_left_x":242,"top_left_y":981,"width":1619,"height":53},"line":16,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b70a9c7f14a4b56ba619f81a63ebe8d","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"4. Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF. Obesity and knee","text_display":"\n4. Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF. Obesity and knee","confidence":1,"confidence_rate":1},{"cnt":[[387,1031],[1656,1031],[1656,1081],[387,1081]],"region":{"top_left_x":386,"top_left_y":1031,"width":1271,"height":50},"line":17,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fd89f9249704be19774c9eb7413f0a5","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"osteoarthritis. The Framingham Study. Ann Intern Med 1988;109(1):18-24.","text_display":" osteoarthritis. The Framingham Study. Ann Intern Med 1988;109(1):18-24.","confidence":1,"confidence_rate":1},{"cnt":[[245,1100],[1858,1100],[1858,1149],[245,1149]],"region":{"top_left_x":244,"top_left_y":1100,"width":1615,"height":50},"line":18,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"540d0d1c416e4c57a2206aef87d3d4cd","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"5. Murphy L, Schwartz TA, Helmick CG, Renner JB, et al. Lifetime risk of symptomatic","text_display":"\n5. Murphy L, Schwartz TA, Helmick CG, Renner JB, et al. Lifetime risk of symptomatic","confidence":1,"confidence_rate":1},{"cnt":[[387,1147],[1351,1147],[1351,1197],[387,1197]],"region":{"top_left_x":386,"top_left_y":1147,"width":966,"height":50},"line":19,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c223f9d7a564ff5ac1e5bb6c2364a54","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"knee osteoarthritis. Arthritis Rheum 2008;59(9):1207-13.","text_display":" knee osteoarthritis. Arthritis Rheum 2008;59(9):1207-13.","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1858,1216],[1858,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1615,"height":50},"line":20,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48ded09bdd6c45a2a06f680ba6342bbd","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"6. Dunlop DD, Manheim LM, Yelin EH, Song J, Chang RW. The cost of arthritis.","text_display":"\n6. Dunlop DD, Manheim LM, Yelin EH, Song J, Chang RW. The cost of arthritis.","confidence":1,"confidence_rate":1},{"cnt":[[387,1263],[1003,1263],[1003,1313],[387,1313]],"region":{"top_left_x":386,"top_left_y":1263,"width":618,"height":50},"line":21,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d0d3ffb4a214f348035d303b174fb9d","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Arthritis Rheum 2003;49(1):101-13.","text_display":" Arthritis Rheum 2003;49(1):101-13.","confidence":1,"confidence_rate":1},{"cnt":[[245,1332],[1863,1332],[1863,1381],[245,1381]],"region":{"top_left_x":244,"top_left_y":1332,"width":1619,"height":50},"line":22,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e24429376b6f453bbb103c7dcdde2180","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"7. Ellsworth JL, Berry J, Bukowski T, Claus J, Feldhaus A, Holderman S, et al. Fibroblast","text_display":"\n7. Ellsworth JL, Berry J, Bukowski T, Claus J, Feldhaus A, Holderman S, et al. Fibroblast","confidence":1,"confidence_rate":1},{"cnt":[[387,1379],[1858,1379],[1858,1431],[387,1431]],"region":{"top_left_x":386,"top_left_y":1379,"width":1473,"height":52},"line":23,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d43658fb1b61453793b653d64f68cc8b","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"growth factor-18 is a trophic factor for mature chondrocytes and their progenitors.","text_display":" growth factor-18 is a trophic factor for mature chondrocytes and their progenitors.","confidence":1,"confidence_rate":1},{"cnt":[[387,1429],[1033,1429],[1033,1476],[387,1476]],"region":{"top_left_x":386,"top_left_y":1428,"width":648,"height":48},"line":24,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8759d905e5d54a52ace6731d97bd7994","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Osteoarthr Cartil 2002;2002(10):-308.","text_display":" Osteoarthr Cartil 2002;2002(10):-308.","confidence":0.998046875,"confidence_rate":0.9999534526348907},{"cnt":[[245,1497],[1858,1497],[1858,1545],[245,1545]],"region":{"top_left_x":244,"top_left_y":1497,"width":1615,"height":48},"line":25,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74eb37e0953f4d74a0794f05f9707b4f","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"8. Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS, Reardon B, et al.","text_display":"\n8. Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS, Reardon B, et al.","confidence":1,"confidence_rate":1},{"cnt":[[387,1543],[1863,1543],[1863,1594],[387,1594]],"region":{"top_left_x":386,"top_left_y":1542,"width":1477,"height":53},"line":26,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c35237210ac14cd5935151da83329e69","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat","text_display":" Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[387,1592],[1777,1592],[1777,1644],[387,1644]],"region":{"top_left_x":386,"top_left_y":1591,"width":1391,"height":53},"line":27,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0bff73a70224c998e7b391851327686","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"model of injury-induced osteoarthritis. Osteoarthritis Cartilage 2005;13(7):623-31.","text_display":" model of injury-induced osteoarthritis. Osteoarthritis Cartilage 2005;13(7):623-31.","confidence":1,"confidence_rate":1},{"cnt":[[245,1661],[1863,1661],[1863,1712],[245,1712]],"region":{"top_left_x":244,"top_left_y":1660,"width":1619,"height":53},"line":28,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c7c5b7377dd4816b19a1b050c4eeeea","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"9. Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fujui S, Itoh N. Structure and","text_display":"\n9. Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fujui S, Itoh N. Structure and","confidence":1,"confidence_rate":1},{"cnt":[[387,1710],[1863,1710],[1863,1760],[387,1760]],"region":{"top_left_x":386,"top_left_y":1710,"width":1477,"height":50},"line":29,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5143d22ad6b49969a28310dcc5b1de3","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. J Biol","text_display":" expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. J Biol","confidence":1,"confidence_rate":1},{"cnt":[[387,1757],[896,1757],[896,1807],[387,1807]],"region":{"top_left_x":386,"top_left_y":1757,"width":510,"height":50},"line":30,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b163f201b8c4e6184d2071126241bd2","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Chem 1998;273(29):18161-4.","text_display":" Chem 1998;273(29):18161-4.","confidence":0.9990234375,"confidence_rate":0.9999684830886739},{"cnt":[[249,1826],[1858,1826],[1858,1876],[249,1876]],"region":{"top_left_x":249,"top_left_y":1826,"width":1610,"height":50},"line":31,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9641d334ed644c86ac551e37459a1cb3","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"10. Kapadia RM, Guntur AR, Reinhold MI, Naski MC. Glycogen synthase kinase 3","text_display":"\n10. Kapadia RM, Guntur AR, Reinhold MI, Naski MC. Glycogen synthase kinase 3","confidence":1,"confidence_rate":1},{"cnt":[[387,1873],[1861,1873],[1861,1927],[387,1927]],"region":{"top_left_x":386,"top_left_y":1873,"width":1475,"height":55},"line":32,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ea9c659ec05415da0e0c544632bd766","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"controls endochondral bone development: contribution of fibroblast growth factor 18 .","text_display":" controls endochondral bone development: contribution of fibroblast growth factor 18 .","confidence":0.97265625,"confidence_rate":0.9997019310118755},{"cnt":[[387,1921],[879,1921],[879,1970],[387,1970]],"region":{"top_left_x":386,"top_left_y":1920,"width":493,"height":51},"line":33,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d76b901b05341a48488117bb3fe2cdf","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Dev Biol 2005;285:496-507.","text_display":" Dev Biol 2005;285:496-507.","confidence":0.9956088066101074,"confidence_rate":0.9998580467538195},{"cnt":[[249,1989],[1863,1989],[1863,2039],[249,2039]],"region":{"top_left_x":249,"top_left_y":1989,"width":1614,"height":50},"line":34,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ee9fcdacf774f888e5e1af9cfc61878","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"11. Davidson D, Blane A, Filion D, Wang H, Plut P, Pfeffer G, et al. Fibroblast growth","text_display":"\n11. Davidson D, Blane A, Filion D, Wang H, Plut P, Pfeffer G, et al. Fibroblast growth","confidence":1,"confidence_rate":1},{"cnt":[[387,2037],[1863,2037],[1863,2090],[387,2090]],"region":{"top_left_x":386,"top_left_y":2036,"width":1477,"height":55},"line":35,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6d06e11257f41149f210edf89d59df8","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol","text_display":" factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol","confidence":0.9970729344058782,"confidence_rate":0.9999677877954348},{"cnt":[[387,2088],[917,2088],[917,2136],[387,2136]],"region":{"top_left_x":386,"top_left_y":2088,"width":532,"height":48},"line":36,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d73a46b8414b4f69b04391792e3ab13e","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Chem 2005;280(21):20509-15.","text_display":" Chem 2005;280(21):20509-15.","confidence":1,"confidence_rate":1},{"cnt":[[249,2320],[1863,2320],[1863,2370],[249,2370]],"region":{"top_left_x":249,"top_left_y":2320,"width":1614,"height":50},"line":37,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f823c809fae6404a98b25c6cb724efff","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"13. Valverde-Franco G, Binette JS, Li W, Wang H, Chai S, Laflamme F, et al. Defects in","text_display":"\n13. Valverde-Franco G, Binette JS, Li W, Wang H, Chai S, Laflamme F, et al. Defects in","confidence":1,"confidence_rate":1},{"cnt":[[387,2368],[1861,2368],[1861,2417],[387,2417]],"region":{"top_left_x":386,"top_left_y":2367,"width":1475,"height":50},"line":38,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f3a4aa506e94397a6436000affc0965","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3","text_display":" articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3","confidence":1,"confidence_rate":1},{"cnt":[[387,2415],[1265,2415],[1265,2464],[387,2464]],"region":{"top_left_x":386,"top_left_y":2414,"width":880,"height":51},"line":39,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00e51848924c4e5bad8739d0300e03d6","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"deficient mice. Hum Mol Genet 2006;15(11):-1783.","text_display":" deficient mice. Hum Mol Genet 2006;15(11):-1783.","confidence":0.77197265625,"confidence_rate":0.9951287682345799},{"cnt":[[593,322],[831,322],[831,376],[593,376]],"region":{"top_left_x":592,"top_left_y":322,"width":240,"height":54},"line":40,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44fb79fc2a1444e6a9c8f2344a5bf07a","type":"section_header","conversion_output":false,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","children_ids":["7f7168a132514f31bf24601a3be37516"],"text":"","text_display":""},{"cnt":[[597,327],[831,327],[831,372],[597,372]],"region":{"top_left_x":597,"top_left_y":326,"width":235,"height":46},"line":41,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f7168a132514f31bf24601a3be37516","type":"text","conversion_output":true,"parent_id":"44fb79fc2a1444e6a9c8f2344a5bf07a","text":"References","text_display":"\n\n\\section*{References}","confidence":1,"confidence_rate":1},{"cnt":[[395,408],[1867,408],[1867,750],[395,750]],"region":{"top_left_x":395,"top_left_y":408,"width":1472,"height":342},"line":42,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83edfd54b5ca4d3ab67274d522f1c978","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Pham T, van der Heijde D, Altman RD, Anderson JJ, Bellamy N, Hochberg M, et al.\nOMERACT-OARSI initiative: Osteoarthritis Research Society International set of\nresponder criteria for osteoarthritis clinical trials revisited. Osteoarthritis Cartilage\n2004;12:389-99.\nHoorman J, Bolen J, Helmick C, Langmaid G. Prevalence of doctor-diagnosed arthritis\nand arthritis-attributable activity limitation-United States, 2003-2005. MMWR","text_display":"\nPham T, van der Heijde D, Altman RD, Anderson JJ, Bellamy N, Hochberg M, et al.\nOMERACT-OARSI initiative: Osteoarthritis Research Society International set of\nresponder criteria for osteoarthritis clinical trials revisited. Osteoarthritis Cartilage\n2004;12:389-99.\nHoorman J, Bolen J, Helmick C, Langmaid G. Prevalence of doctor-diagnosed arthritis\nand arthritis-attributable activity limitation-United States, 2003-2005. MMWR","confidence":0.9985356330871582,"confidence_rate":0.9999969018226726},{"cnt":[[464,704],[1860,706],[1862,721],[1862,775],[1858,784],[1854,786],[1688,788],[764,794],[502,794],[393,788],[388,779],[386,758],[386,706],[391,704]],"region":{"top_left_x":386,"top_left_y":704,"width":1476,"height":90},"line":43,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdc2de8cff004f6b980df4a5692b505c","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"and arthritis-attributable activity limitation-United States, 2003-2005. MMWR\n2006;55(40):1089-92.","text_display":" and arthritis-attributable activity limitation-United States, 2003-2005. MMWR\n2006;55(40):1089-92.","confidence":0.93994140625,"confidence_rate":0.9994707577097788},{"cnt":[[419,804],[1863,804],[1863,868],[419,868]],"region":{"top_left_x":418,"top_left_y":803,"width":1445,"height":65},"line":44,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8c278329d424e25adaaddebdf6cdb15","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"elson DT, Anderson JJ, Naimark A, Swift M, Castelli W, Meenan RF. Obesity and","text_display":" elson DT, Anderson JJ, Naimark A, Swift M, Castelli W, Meenan RF. Obesity and","confidence":1,"confidence_rate":1},{"cnt":[[417,868],[1863,868],[1863,917],[417,917]],"region":{"top_left_x":416,"top_left_y":867,"width":1447,"height":51},"line":45,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39f702eb898d4fef9856615cbf290c3a","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"ymptomatic knee osteoarthritis. Results from the Framingham Study. Arthritis Rheum","text_display":" ymptomatic knee osteoarthritis. Results from the Framingham Study. Arthritis Rheum","confidence":1,"confidence_rate":1},{"cnt":[[417,907],[801,907],[801,965],[417,965]],"region":{"top_left_x":416,"top_left_y":906,"width":386,"height":59},"line":46,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b9838e176cb4a94846b128028771ca7","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"987;30(Suppl 4):S130.","text_display":" 987;30(Suppl 4):S130.","confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[938,956],[964,958],[966,960],[968,971],[968,975],[964,979],[960,981],[708,988],[687,988],[468,986],[438,983],[421,981],[408,977],[401,973],[401,962],[406,958],[831,956]],"region":{"top_left_x":401,"top_left_y":956,"width":567,"height":32},"line":47,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0369a8c3968b48edbe8c71cf4b4cc2fa","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-100.jpg?height=32&width=567&top_left_y=956&top_left_x=401&polygon=537,0,563,2,565,4,567,15,567,19,563,23,559,25,307,32,286,32,67,30,37,27,20,25,7,21,0,17,0,6,5,2,430,0)"},{"cnt":[[1061,954],[1059,956],[1040,956],[1038,958],[1033,958],[1031,956],[1025,956],[1023,958],[1014,958],[1012,956],[1010,956],[1008,958],[960,958],[958,960],[928,960],[926,958],[915,958],[913,960],[911,960],[909,958],[907,958],[904,960],[902,960],[900,958],[898,960],[894,960],[892,958],[889,958],[887,960],[885,960],[883,958],[881,958],[879,960],[877,958],[864,958],[862,960],[859,960],[857,958],[834,958],[831,960],[829,960],[829,965],[831,965],[836,969],[829,975],[812,975],[810,978],[808,978],[806,975],[776,975],[773,973],[769,973],[767,975],[763,975],[761,973],[756,973],[754,971],[754,967],[756,965],[767,965],[769,967],[771,967],[771,962],[743,962],[743,965],[750,965],[754,969],[754,971],[750,975],[733,975],[730,978],[726,978],[724,975],[718,975],[715,978],[713,978],[711,980],[707,975],[698,975],[696,978],[692,978],[688,973],[685,973],[683,975],[681,975],[679,978],[675,978],[670,973],[668,973],[666,975],[664,975],[660,980],[657,980],[655,978],[655,975],[647,975],[642,980],[640,980],[638,978],[638,975],[632,975],[629,978],[627,978],[625,980],[621,975],[614,975],[612,978],[606,978],[604,975],[593,975],[591,978],[589,975],[587,975],[584,973],[582,973],[580,975],[578,975],[576,978],[571,978],[567,973],[565,973],[563,975],[561,975],[559,978],[554,978],[548,971],[548,967],[550,965],[548,962],[537,962],[535,965],[533,962],[531,962],[529,960],[526,962],[513,962],[511,960],[505,960],[503,962],[498,962],[496,960],[468,960],[466,962],[464,962],[462,960],[412,960],[410,958],[387,958],[385,960],[376,960],[374,962],[374,978],[376,980],[382,980],[385,982],[397,982],[400,980],[402,982],[421,982],[425,986],[428,986],[430,984],[436,984],[438,986],[445,986],[447,984],[449,984],[451,982],[455,986],[464,986],[466,984],[471,984],[475,988],[481,988],[486,984],[488,984],[492,988],[501,988],[503,986],[507,990],[516,990],[522,984],[524,986],[535,986],[537,984],[539,984],[546,990],[548,990],[552,986],[552,984],[554,982],[556,982],[561,986],[567,986],[571,982],[574,982],[580,988],[584,988],[589,984],[591,984],[595,988],[597,988],[599,990],[602,990],[604,988],[604,986],[608,982],[612,986],[617,986],[621,982],[625,982],[632,988],[636,988],[636,986],[640,982],[642,982],[651,990],[655,986],[655,984],[657,982],[660,982],[668,990],[672,986],[672,984],[675,982],[677,982],[679,984],[679,986],[683,990],[690,990],[690,986],[692,984],[694,984],[696,986],[696,988],[698,988],[700,990],[707,990],[709,988],[709,986],[711,984],[713,986],[713,988],[715,988],[718,990],[724,990],[728,986],[730,988],[733,988],[735,990],[739,990],[743,986],[746,986],[748,988],[765,988],[767,990],[773,990],[776,988],[788,988],[791,990],[793,990],[795,988],[797,988],[799,990],[801,988],[804,988],[806,986],[810,986],[812,984],[814,984],[816,986],[827,986],[829,984],[831,984],[834,986],[842,986],[844,984],[851,984],[853,986],[859,986],[862,984],[864,984],[866,986],[894,986],[896,984],[902,984],[904,986],[907,986],[909,984],[913,984],[915,982],[917,982],[920,984],[926,984],[928,982],[939,982],[941,984],[943,982],[947,982],[950,980],[952,980],[954,982],[960,982],[971,971],[973,973],[973,978],[971,980],[973,980],[975,978],[978,978],[980,975],[988,975],[990,978],[995,978],[997,975],[999,975],[1001,978],[1003,978],[1005,980],[1018,980],[1021,982],[1081,982],[1083,980],[1085,982],[1134,982],[1137,980],[1139,980],[1141,978],[1143,978],[1143,973],[1141,971],[1141,962],[1137,958],[1134,958],[1132,956],[1128,956],[1126,958],[1124,958],[1121,956],[1083,956],[1081,954],[1074,954],[1072,956],[1066,956],[1063,954]],"region":{"top_left_x":373,"top_left_y":953,"width":770,"height":38},"line":48,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9558c01d3fa34d09b4bf7937a377e1cc","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-100.jpg?height=38&width=770&top_left_y=953&top_left_x=373&polygon=688,1,686,3,667,3,665,5,660,5,658,3,652,3,650,5,641,5,639,3,637,3,635,5,587,5,585,7,555,7,553,5,542,5,540,7,538,7,536,5,534,5,531,7,529,7,527,5,525,7,521,7,519,5,516,5,514,7,512,7,510,5,508,5,506,7,504,5,491,5,489,7,486,7,484,5,461,5,458,7,456,7,456,12,458,12,463,16,456,22,439,22,437,25,435,25,433,22,403,22,400,20,396,20,394,22,390,22,388,20,383,20,381,18,381,14,383,12,394,12,396,14,398,14,398,9,370,9,370,12,377,12,381,16,381,18,377,22,360,22,357,25,353,25,351,22,345,22,342,25,340,25,338,27,334,22,325,22,323,25,319,25,315,20,312,20,310,22,308,22,306,25,302,25,297,20,295,20,293,22,291,22,287,27,284,27,282,25,282,22,274,22,269,27,267,27,265,25,265,22,259,22,256,25,254,25,252,27,248,22,241,22,239,25,233,25,231,22,220,22,218,25,216,22,214,22,211,20,209,20,207,22,205,22,203,25,198,25,194,20,192,20,190,22,188,22,186,25,181,25,175,18,175,14,177,12,175,9,164,9,162,12,160,9,158,9,156,7,153,9,140,9,138,7,132,7,130,9,125,9,123,7,95,7,93,9,91,9,89,7,39,7,37,5,14,5,12,7,3,7,1,9,1,25,3,27,9,27,12,29,24,29,27,27,29,29,48,29,52,33,55,33,57,31,63,31,65,33,72,33,74,31,76,31,78,29,82,33,91,33,93,31,98,31,102,35,108,35,113,31,115,31,119,35,128,35,130,33,134,37,143,37,149,31,151,33,162,33,164,31,166,31,173,37,175,37,179,33,179,31,181,29,183,29,188,33,194,33,198,29,201,29,207,35,211,35,216,31,218,31,222,35,224,35,226,37,229,37,231,35,231,33,235,29,239,33,244,33,248,29,252,29,259,35,263,35,263,33,267,29,269,29,278,37,282,33,282,31,284,29,287,29,295,37,299,33,299,31,302,29,304,29,306,31,306,33,310,37,317,37,317,33,319,31,321,31,323,33,323,35,325,35,327,37,334,37,336,35,336,33,338,31,340,33,340,35,342,35,345,37,351,37,355,33,357,35,360,35,362,37,366,37,370,33,373,33,375,35,392,35,394,37,400,37,403,35,415,35,418,37,420,37,422,35,424,35,426,37,428,35,431,35,433,33,437,33,439,31,441,31,443,33,454,33,456,31,458,31,461,33,469,33,471,31,478,31,480,33,486,33,489,31,491,31,493,33,521,33,523,31,529,31,531,33,534,33,536,31,540,31,542,29,544,29,547,31,553,31,555,29,566,29,568,31,570,29,574,29,577,27,579,27,581,29,587,29,598,18,600,20,600,25,598,27,600,27,602,25,605,25,607,22,615,22,617,25,622,25,624,22,626,22,628,25,630,25,632,27,645,27,648,29,708,29,710,27,712,29,761,29,764,27,766,27,768,25,770,25,770,20,768,18,768,9,764,5,761,5,759,3,755,3,753,5,751,5,748,3,710,3,708,1,701,1,699,3,693,3,690,1)"},{"cnt":[[215,1037],[315,1034],[317,1106],[218,1110]],"region":{"top_left_x":215,"top_left_y":1033,"width":103,"height":77},"line":49,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69cc626f1b294e619489cd95ba3c9705","type":"page_info","conversion_output":false,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":".","text_display":"","confidence":0.5670437876688084,"confidence_rate":0.9097794011132952},{"cnt":[[498,1009],[1506,1018],[1609,1020],[1632,1022],[1652,1024],[1656,1029],[1658,1052],[1658,1059],[1656,1082],[1654,1084],[391,1084],[386,1080],[386,1029],[391,1022],[399,1011],[401,1009]],"region":{"top_left_x":386,"top_left_y":1009,"width":1272,"height":75},"line":50,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36c5a35b78a44fd383d94d06c25849a3","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"osteoarthritis. The Framingham Study. Ann Intern Med 1988;109(1):18-24.","text_display":" osteoarthritis. The Framingham Study. Ann Intern Med 1988;109(1):18-24.","confidence":1,"confidence_rate":1},{"cnt":[[208,1124],[286,1124],[286,1175],[208,1175]],"region":{"top_left_x":208,"top_left_y":1123,"width":78,"height":53},"line":51,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb70279fbfde4b7dad9a5fdbafc12e7c","type":"page_info","conversion_output":false,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"\"","text_display":"","confidence":0.5565400954328652,"confidence_rate":0.9069487425906301},{"cnt":[[438,1170],[1336,1177],[1351,1181],[1351,1203],[1349,1205],[386,1205],[386,1181],[391,1175],[393,1173],[416,1170]],"region":{"top_left_x":386,"top_left_y":1170,"width":965,"height":35},"line":52,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"806d495dfee74d15bf2f3b69ea3dbd25","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-100.jpg?height=35&width=965&top_left_y=1170&top_left_x=386&polygon=52,0,950,7,965,11,965,33,963,35,0,35,0,11,5,5,7,3,30,0)"},{"cnt":[[219,1220],[286,1220],[286,1274],[219,1274]],"region":{"top_left_x":219,"top_left_y":1220,"width":67,"height":55},"line":53,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1668b2dbb2bd47eaa38b451649c7c39e","type":"page_info","conversion_output":false,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"6.","text_display":"","confidence":0.99560546875,"confidence_rate":0.9978003150681002},{"cnt":[[1001,1285],[999,1287],[999,1289],[997,1291],[986,1291],[984,1293],[975,1293],[973,1291],[967,1291],[965,1293],[956,1293],[954,1291],[950,1291],[947,1293],[939,1293],[937,1291],[930,1291],[928,1293],[924,1293],[922,1291],[911,1291],[909,1293],[907,1293],[904,1291],[896,1291],[894,1293],[887,1293],[885,1291],[883,1293],[879,1293],[877,1296],[872,1296],[870,1293],[859,1293],[857,1296],[855,1293],[853,1293],[851,1291],[846,1291],[844,1293],[829,1293],[827,1296],[816,1296],[814,1293],[812,1293],[810,1296],[801,1296],[799,1293],[784,1293],[782,1291],[778,1291],[776,1293],[773,1293],[771,1296],[769,1296],[765,1291],[761,1291],[758,1293],[756,1293],[754,1296],[752,1296],[750,1293],[746,1293],[743,1296],[735,1296],[733,1293],[722,1293],[720,1296],[718,1296],[715,1293],[698,1293],[696,1291],[692,1291],[690,1293],[675,1293],[672,1296],[666,1296],[664,1293],[612,1293],[610,1291],[606,1291],[604,1293],[597,1293],[595,1291],[593,1291],[591,1289],[589,1289],[584,1293],[580,1293],[578,1291],[578,1289],[569,1289],[565,1293],[563,1293],[561,1291],[554,1291],[552,1293],[544,1293],[541,1291],[537,1291],[535,1293],[529,1293],[526,1291],[516,1291],[513,1293],[511,1293],[509,1291],[509,1289],[498,1289],[496,1291],[494,1291],[492,1289],[449,1289],[447,1291],[443,1291],[440,1289],[434,1289],[432,1291],[425,1291],[423,1289],[419,1289],[415,1293],[408,1293],[406,1291],[404,1291],[402,1289],[393,1289],[391,1291],[391,1293],[389,1296],[389,1298],[387,1300],[387,1308],[391,1313],[475,1313],[477,1315],[479,1315],[481,1313],[982,1313],[984,1315],[999,1315],[1001,1313],[1003,1313],[1003,1289],[1001,1287]],"region":{"top_left_x":386,"top_left_y":1284,"width":618,"height":31},"line":54,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fea95e860e524122944c57d728f15dd5","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"M11","text_display":" M11","confidence":0.05588330922252432,"confidence_rate":0.6972849063948557},{"cnt":[[260,1332],[296,1332],[296,1384],[260,1384]],"region":{"top_left_x":259,"top_left_y":1332,"width":38,"height":52},"line":55,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5290bfae7a2445fa0fbec35a0948c1a","type":"page_info","conversion_output":false,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"7.","text_display":"","confidence":0.99267578125,"confidence_rate":0.9963311604331162},{"cnt":[[387,1332],[1865,1332],[1865,1381],[387,1381]],"region":{"top_left_x":386,"top_left_y":1332,"width":1479,"height":50},"line":56,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25c20a76f62f4cab854ef26c50772dd1","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Ellsworth JL, Berry J, Bukowski T, Claus J, Feldhaus A, Holderman S, et al. Fibroblast","text_display":" Ellsworth JL, Berry J, Bukowski T, Claus J, Feldhaus A, Holderman S, et al. Fibroblast","confidence":1,"confidence_rate":1},{"cnt":[[387,1381],[1863,1381],[1863,1433],[387,1433]],"region":{"top_left_x":386,"top_left_y":1381,"width":1477,"height":53},"line":57,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd52aba62eb349b78fedba46e9049a36","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"growth factor-18 is a trophic factor for mature chondrocytes and their progenitors.","text_display":" growth factor-18 is a trophic factor for mature chondrocytes and their progenitors.","confidence":1,"confidence_rate":1},{"cnt":[[387,1431],[1038,1431],[1038,1480],[387,1480]],"region":{"top_left_x":386,"top_left_y":1430,"width":652,"height":51},"line":58,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c441a17e36ab41259133e75fff6171ba","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Osteoarthr Cartil 2002;2002(10):-308.","text_display":" Osteoarthr Cartil 2002;2002(10):-308.","confidence":1,"confidence_rate":1},{"cnt":[[260,1521],[288,1521],[288,1573],[260,1573]],"region":{"top_left_x":259,"top_left_y":1521,"width":29,"height":52},"line":59,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c9eb4aeb8b84e3683c3bf48848f986d","type":"code","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":".","text_display":"\n    .","confidence":0.9541666507720947,"confidence_rate":0.9922110032688446},{"cnt":[[496,1500],[494,1502],[488,1502],[486,1504],[483,1504],[486,1506],[501,1506],[507,1512],[507,1519],[505,1521],[503,1521],[501,1523],[498,1523],[494,1519],[492,1521],[486,1521],[483,1523],[479,1523],[475,1519],[468,1519],[466,1521],[464,1519],[447,1519],[445,1517],[417,1517],[415,1519],[391,1519],[389,1521],[389,1523],[387,1525],[387,1543],[385,1545],[385,1547],[382,1549],[382,1575],[387,1579],[397,1579],[400,1581],[402,1581],[404,1583],[404,1588],[406,1590],[408,1588],[408,1586],[406,1583],[410,1579],[415,1583],[419,1583],[421,1586],[421,1590],[423,1590],[425,1588],[425,1581],[428,1579],[434,1579],[438,1583],[438,1590],[449,1590],[443,1583],[445,1581],[453,1581],[455,1583],[455,1588],[453,1590],[455,1590],[458,1592],[460,1590],[464,1590],[462,1588],[462,1586],[460,1583],[464,1579],[468,1579],[471,1581],[473,1581],[475,1583],[477,1581],[479,1581],[481,1579],[488,1579],[490,1581],[496,1581],[498,1579],[503,1579],[505,1581],[507,1581],[509,1583],[511,1583],[513,1581],[535,1581],[537,1579],[539,1581],[546,1581],[548,1579],[574,1579],[576,1581],[580,1581],[582,1579],[604,1579],[606,1581],[608,1581],[610,1583],[614,1583],[619,1579],[627,1579],[629,1581],[632,1579],[642,1579],[645,1581],[651,1581],[653,1579],[660,1579],[662,1581],[668,1581],[670,1579],[675,1579],[677,1581],[685,1581],[688,1579],[694,1579],[696,1581],[698,1581],[700,1579],[711,1579],[713,1581],[718,1581],[720,1579],[728,1579],[730,1581],[735,1581],[737,1579],[746,1579],[748,1581],[754,1581],[756,1579],[761,1579],[763,1581],[765,1581],[767,1583],[771,1583],[773,1581],[780,1581],[782,1583],[784,1583],[786,1581],[788,1581],[791,1579],[797,1579],[799,1581],[801,1581],[804,1579],[814,1579],[816,1581],[823,1581],[825,1579],[831,1579],[834,1581],[840,1581],[842,1579],[849,1579],[851,1581],[855,1581],[857,1579],[900,1579],[902,1581],[911,1581],[913,1579],[915,1581],[920,1581],[922,1583],[924,1583],[926,1581],[941,1581],[943,1579],[973,1579],[975,1581],[978,1579],[986,1579],[988,1581],[995,1581],[997,1579],[1003,1579],[1005,1581],[1012,1581],[1014,1579],[1021,1579],[1023,1581],[1029,1581],[1031,1579],[1038,1579],[1040,1581],[1083,1581],[1085,1579],[1089,1579],[1091,1581],[1098,1581],[1100,1579],[1102,1579],[1104,1581],[1117,1581],[1119,1579],[1124,1579],[1126,1581],[1132,1581],[1134,1579],[1141,1579],[1143,1581],[1162,1581],[1164,1583],[1167,1581],[1201,1581],[1203,1579],[1210,1579],[1212,1581],[1218,1581],[1220,1579],[1227,1579],[1229,1581],[1235,1581],[1238,1579],[1242,1579],[1244,1581],[1253,1581],[1255,1579],[1280,1579],[1283,1581],[1306,1581],[1308,1579],[1313,1579],[1315,1581],[1321,1581],[1323,1579],[1386,1579],[1388,1581],[1390,1579],[1401,1579],[1403,1581],[1405,1581],[1407,1579],[1435,1579],[1437,1581],[1459,1581],[1461,1579],[1465,1579],[1467,1581],[1478,1581],[1480,1579],[1558,1579],[1560,1581],[1562,1581],[1564,1579],[1626,1579],[1629,1581],[1631,1581],[1633,1579],[1861,1579],[1863,1577],[1863,1530],[1861,1528],[1861,1525],[1757,1525],[1755,1528],[1753,1528],[1751,1525],[1379,1525],[1377,1528],[1375,1528],[1373,1525],[1360,1525],[1358,1528],[1356,1525],[1121,1525],[1119,1528],[1117,1528],[1115,1525],[1012,1525],[1010,1523],[1005,1523],[1003,1525],[997,1525],[995,1523],[984,1523],[982,1525],[943,1525],[941,1523],[932,1523],[930,1525],[928,1523],[926,1523],[924,1521],[924,1519],[922,1517],[922,1512],[924,1510],[926,1510],[928,1508],[930,1508],[932,1510],[939,1510],[943,1506],[950,1506],[952,1508],[954,1508],[956,1506],[1001,1506],[1003,1508],[1005,1508],[1008,1506],[1044,1506],[1046,1504],[1068,1504],[1068,1502],[1061,1502],[1059,1500],[1057,1500],[1055,1502],[1046,1502],[1044,1500],[1036,1500],[1033,1502],[1027,1502],[1025,1500]],"region":{"top_left_x":382,"top_left_y":1499,"width":1481,"height":93},"line":60,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24d692276858488c9bcc9eebe7c34984","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat","text_display":" Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat","confidence":0.9980480668600649,"confidence_rate":0.9999777975118874},{"cnt":[[374,1577],[1779,1577],[1779,1644],[374,1644]],"region":{"top_left_x":373,"top_left_y":1576,"width":1406,"height":68},"line":61,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45458bad867145e588fd37f2f29c38e2","type":"code","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"model of injury-induced osteoarthritis. Osteoarthritis Cartilage 2005;13(7):623-31.","text_display":"\n        model of injury-induced osteoarthritis. Osteoarthritis Cartilage 2005;13(7):623-31.","confidence":1,"confidence_rate":1},{"cnt":[[226,1659],[288,1659],[288,1710],[226,1710]],"region":{"top_left_x":225,"top_left_y":1658,"width":63,"height":53},"line":62,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebf7ba0bdfd242ac974fb9b54f9aef09","type":"page_info","conversion_output":false,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"9.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[382,1646],[1865,1646],[1865,1702],[382,1702]],"region":{"top_left_x":382,"top_left_y":1645,"width":1483,"height":57},"line":63,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03ba0eabad8245f395985f2b14b17d29","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fujui S, Itoh N. Structure and","text_display":"\n\nOhbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fujui S, Itoh N. Structure and","confidence":1,"confidence_rate":1},{"cnt":[[387,1716],[1863,1712],[1863,1763],[387,1766]],"region":{"top_left_x":386,"top_left_y":1712,"width":1477,"height":55},"line":64,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55af3b351ef9488cb6f8d0176713c16a","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. J Biol","text_display":" expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. J Biol","confidence":1,"confidence_rate":1},{"cnt":[[415,1762],[892,1762],[892,1807],[415,1807]],"region":{"top_left_x":414,"top_left_y":1761,"width":478,"height":46},"line":65,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18e41c7b52034c028671b74ffef921e8","type":"code","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Chem 1998;273(29):18161-4.","text_display":"\n    Chem 1998;273(29):18161-4.","confidence":0.9990234375,"confidence_rate":0.9999684830886739},{"cnt":[[385,1826],[1861,1826],[1861,1871],[385,1871]],"region":{"top_left_x":384,"top_left_y":1826,"width":1477,"height":46},"line":66,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49d0471efa8e4456bbd4918002d33c8c","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Kapadia RM, Guntur AR, Reinhold MI, Naski MC. Glycogen synthase kinase 3","text_display":"\n\nKapadia RM, Guntur AR, Reinhold MI, Naski MC. Glycogen synthase kinase 3","confidence":1,"confidence_rate":1},{"cnt":[[374,1878],[1861,1878],[1861,1927],[374,1927]],"region":{"top_left_x":373,"top_left_y":1877,"width":1488,"height":51},"line":67,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f7046b101414d48919a6ef75b7014cd","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"controls endochondral bone development: contribution of fibroblast growth factor 18.","text_display":" controls endochondral bone development: contribution of fibroblast growth factor 18.","confidence":0.98828125,"confidence_rate":0.9998660549288053},{"cnt":[[387,1925],[874,1925],[874,1970],[387,1970]],"region":{"top_left_x":386,"top_left_y":1925,"width":489,"height":46},"line":68,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbecaf1c970e4aa1b10d28deda7db6cb","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Dev Biol 2005;285:496-507.","text_display":" Dev Biol 2005;285:496-507.","confidence":1,"confidence_rate":1},{"cnt":[[387,1989],[1863,1989],[1863,2032],[387,2032]],"region":{"top_left_x":386,"top_left_y":1989,"width":1477,"height":44},"line":69,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fd870ffacaa4d02b433af7bd8e5dde8","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Davidson D, Blane A, Filion D, Wang H, Plut P, Pfeffer G, et al. Fibroblast growth","text_display":"\n\nDavidson D, Blane A, Filion D, Wang H, Plut P, Pfeffer G, et al. Fibroblast growth","confidence":1,"confidence_rate":1},{"cnt":[[387,2045],[1858,2045],[1858,2088],[387,2088]],"region":{"top_left_x":386,"top_left_y":2045,"width":1473,"height":44},"line":70,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36e7396e9eff4f5db2288869856fb764","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol","text_display":" factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol","confidence":0.9990236759185791,"confidence_rate":0.9999892659807285},{"cnt":[[374,2088],[909,2088],[909,2138],[374,2138]],"region":{"top_left_x":373,"top_left_y":2088,"width":536,"height":50},"line":71,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4452dc776b9046a7bca292571edc0cc1","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Chem 2005;280(21):20509-15.","text_display":" Chem 2005;280(21):20509-15.","confidence":1,"confidence_rate":1},{"cnt":[[350,2144],[1869,2144],[1869,2314],[350,2314]],"region":{"top_left_x":350,"top_left_y":2144,"width":1520,"height":170},"line":72,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5beb06950624ff589b79a5abbefae71","type":"table_spanning_cell","conversion_output":false,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","children_ids":["0d76afd302d0404c9d3c9b9f5694533e"],"text":"","text_display":"\\begin{tabular}{l}\n12. Valverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Hum Mol Genet 2004;13(3):271-84. \\\\\nValverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice.\n\\end{tabular}"},{"cnt":[[365,2153],[1867,2153],[1867,2303],[365,2303]],"region":{"top_left_x":365,"top_left_y":2152,"width":1502,"height":152},"line":73,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d76afd302d0404c9d3c9b9f5694533e","type":"complex_cell","conversion_output":false,"parent_id":"c5beb06950624ff589b79a5abbefae71","children_ids":["58fb68df63424a699866139b5afb0199","b37ca30066d948518ecfb2fbcb95402a","460ffa4d442d488195a00cfc903c9368","971bf40db30e4ee3b84765030cd0d222","65a477b0bd7641c6ad7cf0c14fb8825a"],"text":"\\begin{tabular}{l}\n12. Valverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Hum Mol Genet 2004;13(3):271-84. \\\\\nValverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n12. Valverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Hum Mol Genet 2004;13(3):271-84. \\\\\nValverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice.\n\\end{tabular}"},{"cnt":[[249,2153],[1861,2153],[1861,2206],[249,2206]],"region":{"top_left_x":249,"top_left_y":2152,"width":1612,"height":55},"line":74,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58fb68df63424a699866139b5afb0199","type":"text","conversion_output":true,"parent_id":"0d76afd302d0404c9d3c9b9f5694533e","text":"12. Valverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D,","text_display":"12. Valverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D,","confidence":1,"confidence_rate":1},{"cnt":[[387,2204],[1858,2204],[1858,2254],[387,2254]],"region":{"top_left_x":386,"top_left_y":2204,"width":1473,"height":50},"line":75,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b37ca30066d948518ecfb2fbcb95402a","type":"text","conversion_output":true,"parent_id":"0d76afd302d0404c9d3c9b9f5694533e","text":"et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice.","text_display":" et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice.","confidence":1,"confidence_rate":1},{"cnt":[[387,2252],[1005,2252],[1005,2301],[387,2301]],"region":{"top_left_x":386,"top_left_y":2251,"width":620,"height":50},"line":76,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"460ffa4d442d488195a00cfc903c9368","type":"text","conversion_output":true,"parent_id":"0d76afd302d0404c9d3c9b9f5694533e","text":"Hum Mol Genet 2004;13(3):271-84.","text_display":" Hum Mol Genet 2004;13(3):271-84.","confidence":1,"confidence_rate":1},{"cnt":[[385,2157],[1858,2157],[1858,2206],[385,2206]],"region":{"top_left_x":384,"top_left_y":2157,"width":1475,"height":50},"line":77,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"971bf40db30e4ee3b84765030cd0d222","type":"text","conversion_output":true,"parent_id":"0d76afd302d0404c9d3c9b9f5694533e","text":"Valverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D,","text_display":"\nValverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D,","confidence":1,"confidence_rate":1},{"cnt":[[387,2204],[1858,2204],[1858,2254],[387,2254]],"region":{"top_left_x":386,"top_left_y":2204,"width":1473,"height":50},"line":78,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65a477b0bd7641c6ad7cf0c14fb8825a","type":"text","conversion_output":true,"parent_id":"0d76afd302d0404c9d3c9b9f5694533e","text":"et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice.","text_display":" et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice.","confidence":1,"confidence_rate":1},{"cnt":[[391,2299],[389,2301],[387,2301],[387,2342],[389,2344],[389,2353],[391,2355],[391,2357],[395,2357],[400,2361],[400,2365],[397,2368],[393,2368],[391,2365],[389,2368],[387,2368],[385,2370],[385,2383],[382,2385],[382,2419],[385,2421],[385,2436],[387,2438],[387,2451],[385,2454],[385,2456],[387,2458],[387,2477],[389,2479],[389,2481],[387,2484],[387,2486],[385,2488],[385,2490],[389,2494],[412,2494],[415,2492],[453,2492],[455,2490],[460,2490],[462,2492],[471,2492],[473,2490],[518,2490],[520,2492],[522,2492],[524,2490],[535,2490],[537,2492],[539,2492],[541,2490],[552,2490],[554,2492],[559,2492],[561,2490],[565,2490],[567,2492],[576,2492],[578,2490],[584,2490],[587,2492],[591,2492],[593,2490],[602,2490],[604,2492],[610,2492],[612,2490],[619,2490],[621,2492],[625,2492],[627,2490],[655,2490],[657,2492],[660,2492],[662,2490],[776,2490],[778,2492],[780,2492],[782,2490],[827,2490],[829,2492],[831,2492],[834,2490],[844,2490],[846,2492],[849,2492],[851,2490],[862,2490],[864,2492],[866,2492],[868,2490],[881,2490],[883,2492],[885,2490],[999,2490],[1001,2492],[1003,2492],[1005,2490],[1016,2490],[1018,2492],[1021,2492],[1023,2490],[1033,2490],[1036,2492],[1040,2492],[1042,2490],[1048,2490],[1051,2492],[1057,2492],[1059,2490],[1068,2490],[1070,2492],[1072,2492],[1074,2490],[1085,2490],[1087,2492],[1089,2492],[1091,2490],[1102,2490],[1104,2492],[1106,2492],[1109,2490],[1119,2490],[1121,2492],[1126,2492],[1128,2490],[1130,2492],[1149,2492],[1152,2494],[1259,2494],[1261,2492],[1261,2490],[1263,2488],[1263,2484],[1261,2481],[1261,2436],[1263,2434],[1263,2432],[1261,2430],[1261,2417],[1257,2413],[1257,2411],[1259,2408],[1261,2408],[1261,2370],[1259,2368],[1255,2368],[1253,2365],[1250,2365],[1248,2368],[1220,2368],[1218,2365],[1214,2365],[1212,2368],[1210,2368],[1207,2370],[1205,2370],[1203,2372],[1201,2370],[1199,2370],[1197,2372],[1195,2372],[1195,2378],[1192,2380],[1190,2380],[1188,2378],[1188,2374],[1190,2372],[1188,2372],[1186,2370],[1162,2370],[1160,2372],[1160,2378],[1158,2380],[1156,2380],[1154,2378],[1154,2374],[1152,2372],[1147,2372],[1145,2374],[1145,2376],[1141,2380],[1137,2380],[1134,2378],[1134,2376],[1132,2374],[1132,2372],[1130,2372],[1130,2374],[1128,2376],[1128,2378],[1124,2383],[1121,2383],[1119,2380],[1119,2378],[1117,2376],[1117,2372],[1115,2370],[1098,2370],[1094,2374],[1094,2378],[1089,2383],[1087,2383],[1085,2380],[1085,2374],[1081,2370],[1079,2370],[1074,2374],[1074,2378],[1072,2380],[1070,2380],[1068,2378],[1068,2374],[1066,2372],[1061,2372],[1059,2374],[1059,2376],[1055,2380],[1053,2380],[1051,2378],[1051,2374],[1048,2372],[1044,2372],[1040,2376],[1040,2378],[1038,2380],[1036,2380],[1033,2378],[1033,2374],[1031,2372],[1025,2372],[1023,2374],[1023,2376],[1018,2380],[1016,2378],[1016,2372],[1008,2372],[1005,2374],[1005,2378],[1003,2380],[1001,2380],[999,2378],[999,2374],[997,2372],[990,2372],[988,2374],[988,2376],[984,2380],[982,2378],[982,2372],[980,2372],[975,2368],[967,2368],[965,2370],[956,2370],[956,2372],[954,2374],[954,2378],[952,2380],[950,2380],[947,2378],[947,2372],[945,2370],[939,2370],[937,2372],[924,2372],[920,2376],[920,2378],[917,2380],[915,2380],[913,2378],[913,2376],[911,2374],[911,2372],[909,2372],[907,2370],[904,2370],[900,2374],[902,2376],[900,2378],[898,2378],[896,2376],[896,2372],[889,2372],[885,2376],[885,2378],[883,2380],[881,2380],[879,2378],[879,2374],[877,2372],[872,2372],[870,2374],[868,2374],[868,2376],[864,2380],[862,2378],[862,2372],[859,2372],[857,2370],[855,2370],[851,2374],[851,2378],[849,2380],[846,2380],[844,2378],[844,2372],[842,2372],[840,2370],[838,2370],[836,2372],[836,2374],[834,2376],[834,2378],[829,2383],[825,2378],[825,2372],[823,2370],[821,2370],[821,2372],[819,2374],[819,2378],[816,2380],[816,2385],[814,2387],[812,2387],[810,2385],[810,2380],[808,2378],[808,2372],[804,2372],[804,2374],[799,2378],[799,2380],[797,2383],[795,2383],[791,2378],[791,2374],[788,2372],[782,2378],[782,2380],[780,2383],[778,2383],[776,2380],[776,2378],[773,2376],[773,2374],[771,2372],[765,2378],[765,2380],[763,2383],[761,2383],[758,2380],[758,2378],[756,2376],[756,2374],[754,2372],[748,2378],[748,2380],[746,2383],[743,2383],[741,2380],[741,2378],[739,2376],[739,2374],[737,2372],[735,2372],[730,2376],[730,2378],[728,2380],[726,2380],[724,2378],[724,2374],[722,2372],[720,2372],[713,2378],[713,2380],[709,2385],[707,2383],[707,2380],[705,2378],[705,2372],[703,2370],[700,2370],[696,2374],[696,2378],[694,2380],[692,2380],[690,2378],[690,2374],[688,2372],[685,2372],[683,2374],[683,2376],[677,2383],[675,2383],[670,2378],[670,2374],[668,2374],[660,2383],[657,2383],[651,2376],[651,2372],[649,2372],[645,2376],[645,2378],[642,2380],[640,2380],[638,2378],[638,2372],[636,2372],[634,2370],[632,2370],[632,2372],[629,2374],[629,2376],[623,2383],[621,2380],[621,2378],[619,2376],[621,2374],[619,2372],[614,2372],[612,2374],[612,2376],[608,2380],[606,2380],[604,2378],[604,2372],[597,2372],[593,2376],[593,2378],[591,2380],[589,2380],[587,2378],[587,2372],[580,2372],[578,2374],[576,2374],[576,2376],[574,2378],[571,2378],[569,2376],[569,2372],[563,2372],[563,2374],[556,2380],[554,2380],[552,2378],[552,2376],[550,2374],[550,2372],[546,2372],[544,2374],[541,2374],[541,2376],[537,2380],[535,2378],[535,2374],[533,2372],[531,2372],[522,2380],[520,2380],[518,2378],[518,2374],[516,2372],[509,2372],[507,2374],[507,2376],[505,2378],[503,2378],[501,2376],[503,2374],[496,2368],[494,2368],[490,2372],[488,2372],[486,2370],[481,2370],[479,2368],[477,2368],[475,2370],[462,2370],[460,2372],[458,2372],[455,2374],[453,2374],[451,2372],[449,2372],[447,2370],[445,2370],[436,2378],[434,2378],[432,2376],[432,2372],[425,2372],[421,2376],[421,2378],[419,2380],[417,2380],[415,2378],[415,2374],[412,2372],[410,2372],[408,2370],[408,2368],[406,2365],[406,2361],[410,2357],[419,2357],[421,2355],[423,2355],[425,2357],[505,2357],[505,2355],[507,2353],[507,2350],[509,2348],[513,2348],[513,2344],[511,2342],[509,2344],[507,2344],[505,2346],[503,2346],[503,2348],[501,2350],[498,2348],[498,2342],[496,2340],[496,2338],[501,2333],[501,2327],[503,2325],[505,2325],[507,2327],[507,2333],[509,2333],[511,2335],[513,2335],[513,2329],[520,2322],[522,2322],[524,2325],[524,2329],[526,2331],[526,2333],[529,2335],[531,2335],[533,2333],[531,2331],[533,2329],[533,2327],[537,2322],[541,2327],[541,2333],[546,2338],[546,2340],[544,2342],[544,2348],[546,2348],[548,2350],[548,2346],[550,2344],[552,2344],[554,2346],[554,2348],[552,2350],[552,2353],[556,2353],[556,2350],[559,2348],[561,2348],[565,2353],[567,2353],[569,2355],[574,2355],[574,2353],[576,2350],[578,2350],[580,2353],[582,2353],[584,2355],[591,2355],[591,2353],[595,2348],[597,2350],[599,2350],[604,2355],[608,2355],[608,2348],[604,2353],[602,2353],[599,2350],[599,2342],[595,2342],[593,2344],[589,2344],[584,2340],[584,2335],[587,2333],[584,2331],[584,2329],[589,2325],[591,2325],[593,2327],[593,2333],[597,2338],[599,2335],[599,2329],[606,2322],[610,2327],[610,2331],[614,2335],[617,2335],[619,2333],[619,2329],[623,2325],[625,2325],[627,2327],[627,2331],[629,2333],[634,2333],[634,2327],[636,2325],[638,2325],[640,2322],[645,2327],[645,2331],[649,2335],[651,2335],[651,2333],[653,2331],[653,2327],[657,2322],[662,2327],[662,2329],[664,2331],[666,2331],[668,2333],[672,2329],[672,2327],[675,2325],[677,2327],[677,2331],[679,2333],[679,2335],[681,2338],[681,2344],[683,2346],[683,2344],[685,2342],[685,2333],[688,2331],[688,2327],[692,2322],[694,2322],[696,2325],[696,2331],[700,2335],[700,2338],[703,2340],[698,2344],[698,2350],[700,2353],[705,2353],[705,2350],[703,2348],[703,2338],[705,2335],[707,2335],[707,2327],[709,2325],[711,2325],[713,2327],[713,2331],[718,2335],[718,2338],[720,2340],[720,2342],[718,2344],[718,2346],[720,2346],[720,2340],[722,2338],[724,2338],[726,2340],[726,2350],[728,2350],[730,2348],[737,2348],[737,2333],[739,2331],[739,2327],[743,2322],[748,2327],[748,2329],[752,2333],[754,2333],[754,2327],[758,2322],[763,2322],[765,2325],[765,2329],[769,2333],[769,2335],[771,2333],[771,2327],[776,2322],[780,2322],[782,2325],[782,2327],[784,2329],[784,2331],[786,2333],[786,2327],[791,2322],[797,2322],[799,2325],[799,2327],[801,2329],[804,2329],[804,2327],[806,2325],[808,2325],[810,2322],[814,2322],[816,2325],[816,2329],[819,2329],[821,2331],[823,2329],[823,2327],[825,2325],[827,2325],[829,2322],[831,2322],[834,2325],[834,2329],[838,2333],[838,2331],[840,2329],[840,2327],[844,2322],[849,2322],[851,2325],[851,2327],[855,2331],[855,2333],[857,2333],[857,2329],[862,2325],[866,2325],[868,2327],[868,2331],[872,2335],[874,2333],[874,2327],[879,2322],[883,2322],[885,2325],[885,2327],[887,2329],[887,2331],[889,2333],[889,2335],[892,2335],[892,2329],[898,2322],[900,2322],[902,2325],[902,2327],[904,2329],[904,2331],[907,2333],[907,2335],[909,2335],[911,2333],[909,2331],[909,2329],[915,2322],[920,2327],[920,2329],[922,2331],[922,2333],[924,2335],[926,2335],[926,2329],[932,2322],[937,2327],[937,2331],[941,2335],[943,2335],[943,2329],[950,2322],[952,2322],[954,2325],[954,2329],[958,2333],[958,2335],[960,2335],[960,2333],[962,2331],[962,2329],[965,2327],[965,2325],[967,2322],[971,2327],[971,2329],[975,2333],[975,2340],[973,2342],[971,2342],[967,2346],[967,2348],[965,2350],[962,2350],[960,2348],[960,2346],[962,2344],[960,2342],[958,2342],[956,2344],[956,2346],[958,2348],[958,2350],[960,2350],[962,2353],[965,2353],[967,2355],[969,2355],[969,2353],[971,2350],[973,2350],[978,2355],[986,2355],[988,2353],[993,2353],[995,2355],[1001,2355],[1005,2350],[1008,2350],[1010,2353],[1014,2353],[1012,2350],[1012,2344],[1005,2344],[1003,2346],[1001,2346],[995,2340],[995,2333],[997,2331],[997,2329],[999,2327],[999,2325],[1001,2322],[1003,2322],[1005,2325],[1010,2325],[1012,2322],[1014,2325],[1016,2322],[1023,2322],[1025,2325],[1031,2325],[1033,2322],[1038,2322],[1040,2325],[1040,2329],[1042,2331],[1044,2331],[1046,2329],[1046,2327],[1053,2320],[1055,2320],[1059,2325],[1066,2325],[1068,2322],[1072,2322],[1076,2327],[1079,2325],[1081,2325],[1083,2322],[1089,2322],[1094,2327],[1096,2325],[1098,2325],[1100,2322],[1109,2322],[1111,2325],[1113,2322],[1119,2322],[1121,2320],[1124,2320],[1126,2322],[1137,2322],[1139,2320],[1141,2320],[1143,2322],[1158,2322],[1162,2327],[1164,2327],[1169,2322],[1190,2322],[1192,2320],[1195,2322],[1210,2322],[1214,2327],[1214,2329],[1216,2331],[1218,2331],[1218,2327],[1220,2325],[1222,2325],[1225,2322],[1229,2322],[1231,2325],[1235,2325],[1238,2327],[1240,2327],[1242,2325],[1244,2325],[1246,2327],[1246,2333],[1248,2335],[1248,2338],[1244,2342],[1242,2342],[1238,2346],[1233,2346],[1231,2348],[1229,2348],[1227,2350],[1222,2350],[1218,2346],[1218,2342],[1214,2342],[1212,2344],[1212,2346],[1205,2353],[1207,2355],[1207,2357],[1210,2357],[1212,2355],[1214,2355],[1216,2357],[1257,2357],[1261,2353],[1261,2342],[1259,2340],[1259,2333],[1257,2331],[1257,2327],[1261,2322],[1261,2320],[1257,2316],[1242,2316],[1240,2314],[1238,2314],[1235,2316],[1225,2316],[1222,2314],[1222,2312],[1225,2310],[1229,2310],[1233,2305],[1238,2310],[1244,2310],[1244,2307],[1248,2303],[1255,2303],[1257,2301],[1255,2299],[1238,2299],[1235,2301],[1229,2301],[1227,2299],[1222,2299],[1220,2301],[1210,2301],[1207,2299],[1205,2301],[1199,2301],[1197,2303],[1195,2303],[1192,2301],[1188,2301],[1186,2303],[1177,2303],[1175,2301],[1173,2301],[1171,2303],[1160,2303],[1158,2301],[1156,2301],[1154,2303],[1149,2303],[1149,2305],[1154,2310],[1154,2312],[1152,2314],[1147,2314],[1145,2316],[1126,2316],[1124,2318],[1121,2318],[1119,2316],[1111,2316],[1109,2318],[1106,2318],[1104,2316],[1102,2316],[1100,2314],[1091,2314],[1089,2312],[1091,2310],[1091,2307],[1094,2305],[1098,2305],[1100,2307],[1100,2310],[1104,2310],[1106,2307],[1106,2303],[1104,2301],[1102,2303],[1091,2303],[1089,2301],[1087,2301],[1085,2303],[1079,2303],[1076,2305],[1072,2301],[1070,2301],[1068,2303],[1057,2303],[1055,2301],[1051,2301],[1048,2303],[1042,2303],[1040,2301],[1036,2301],[1033,2303],[1027,2303],[1025,2305],[1023,2303],[1016,2303],[1014,2305],[1012,2303],[1010,2303],[1008,2305],[1005,2303],[993,2303],[990,2305],[988,2305],[986,2303],[984,2303],[982,2305],[975,2305],[973,2307],[971,2305],[969,2305],[967,2303],[907,2303],[904,2305],[902,2303],[821,2303],[819,2305],[816,2303],[683,2303],[681,2305],[679,2305],[677,2303],[627,2303],[625,2301],[623,2301],[621,2303],[610,2303],[608,2301],[606,2301],[604,2303],[593,2303],[591,2301],[580,2301],[578,2303],[576,2303],[574,2301],[563,2301],[561,2303],[559,2303],[556,2301],[552,2301],[550,2303],[548,2301],[546,2303],[541,2303],[539,2301],[537,2301],[535,2303],[524,2303],[522,2301],[520,2301],[518,2303],[516,2303],[513,2301],[511,2303],[507,2303],[505,2301],[488,2301],[486,2299],[483,2301],[473,2301],[471,2299],[468,2299],[466,2301],[455,2301],[453,2299],[451,2299],[449,2301],[447,2301],[445,2299],[443,2301],[438,2301],[436,2299]],"region":{"top_left_x":382,"top_left_y":2298,"width":882,"height":197},"line":79,"column":1,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fef9511c7ba547e4909ff5f4d754e4a0","type":"text","conversion_output":true,"parent_id":"ec90ae1f6f81436bbcee74b96e9ca438","text":"Valver\narticular cartilage metabolism and early arthritis in\ndeficient mice. Hum Mol Genet 2006;15(11):-1783.","text_display":" Valver\narticular cartilage metabolism and early arthritis in\ndeficient mice. Hum Mol Genet 2006;15(11):-1783.","confidence":0.8753573936505983,"confidence_rate":0.9990143895435121},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":80,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c8d56e715e9b4fec8b16b6aca6b417ad","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":81,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f9f069358a814b2fa0f17c424d15d314","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1491,2531],[1596,2531],[1596,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2530,"width":106,"height":34},"line":82,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"74e0a25245ea4a908f4f94afaa7c6413","type":"page_info","conversion_output":false,"text":"100/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-101","page":101,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00483028002640f4ba3cac4065940c51","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80e73a62647c44e3938bd122c0ac096e","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87846e5b3a9b4d1dbaf3e591c2e7312a","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[247,301],[1863,301],[1863,350],[247,350]],"region":{"top_left_x":247,"top_left_y":300,"width":1616,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cd80bbae74c405fa4a4e41f1e6398ad","type":"text","conversion_output":true,"text":"14. Liu Z, Xu J, Colvin S, et al. Coordination of chondrogenesis and osteogenesis by","text_display":"\n14. Liu Z, Xu J, Colvin S, et al. Coordination of chondrogenesis and osteogenesis by","confidence":1,"confidence_rate":1},{"cnt":[[387,348],[1338,348],[1338,400],[387,400]],"region":{"top_left_x":386,"top_left_y":348,"width":953,"height":52},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d967e2951b348c2b5cbbf171b33cd17","type":"text","conversion_output":true,"text":"fibroblast growth factor 18. Genes Dev 2002;16:859-69.","text_display":" fibroblast growth factor 18. Genes Dev 2002;16:859-69.","confidence":0.9746444225311279,"confidence_rate":0.9995647969428865},{"cnt":[[249,417],[1861,417],[1861,468],[249,468]],"region":{"top_left_x":249,"top_left_y":416,"width":1612,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06fa62357e214a199ebcb44c261e017c","type":"text","conversion_output":true,"text":"15. Ohbayashi N, Shibayama M, Kurotaki Y. FGF18 is required for normal cell","text_display":"\n15. Ohbayashi N, Shibayama M, Kurotaki Y. FGF18 is required for normal cell","confidence":1,"confidence_rate":1},{"cnt":[[387,466],[1863,466],[1863,518],[387,518]],"region":{"top_left_x":386,"top_left_y":466,"width":1477,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e6e4c50cc054e97861b73e60117d5cd","type":"text","conversion_output":true,"text":"proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev","text_display":" proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev","confidence":1,"confidence_rate":1},{"cnt":[[387,516],[655,516],[655,561],[387,561]],"region":{"top_left_x":386,"top_left_y":515,"width":270,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe34b84c25644391840144a212443fc9","type":"text","conversion_output":true,"text":"2002;16:870-9.","text_display":" 2002;16:870-9.","confidence":1,"confidence_rate":1},{"cnt":[[249,580],[1863,580],[1863,634],[249,634]],"region":{"top_left_x":249,"top_left_y":580,"width":1614,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa780010c31047b39226991ed10e5f6b","type":"text","conversion_output":true,"text":"16. Zhang W, Robertson J, Jones AC, Dieppe PA, Doherty M. The placebo effect and its","text_display":"\n16. Zhang W, Robertson J, Jones AC, Dieppe PA, Doherty M. The placebo effect and its","confidence":1,"confidence_rate":1},{"cnt":[[387,632],[1863,632],[1863,681],[387,681]],"region":{"top_left_x":386,"top_left_y":631,"width":1477,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"acc4d742b89b4937b0ec7c382f7935fb","type":"text","conversion_output":true,"text":"determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann","text_display":" determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann","confidence":1,"confidence_rate":1},{"cnt":[[387,679],[965,679],[965,728],[387,728]],"region":{"top_left_x":386,"top_left_y":678,"width":579,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83e2630ba86843968d46555ede67213b","type":"text","conversion_output":true,"text":"Rheum Dis 2008;67(12):1716-23.","text_display":" Rheum Dis 2008;67(12):1716-23.","confidence":0.54638671875,"confidence_rate":0.9828788816792308},{"cnt":[[249,748],[1863,748],[1863,797],[249,797]],"region":{"top_left_x":249,"top_left_y":747,"width":1614,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de9833470be04085b743374fee636348","type":"text","conversion_output":true,"text":"17. Cooper C, Reginster JY, Chapurlat R, Christiansen C, Genant H, et al. Efficacy and","text_display":"\n17. Cooper C, Reginster JY, Chapurlat R, Christiansen C, Genant H, et al. Efficacy and","confidence":1,"confidence_rate":1},{"cnt":[[387,795],[1863,795],[1863,844],[387,844]],"region":{"top_left_x":386,"top_left_y":794,"width":1477,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c992d1432144b129c788749770ff94c","type":"text","conversion_output":true,"text":"safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and","text_display":" safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and","confidence":1,"confidence_rate":1},{"cnt":[[387,842],[1863,842],[1863,896],[387,896]],"region":{"top_left_x":386,"top_left_y":842,"width":1477,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d28c6a46318040a4b63157563eb91c02","type":"text","conversion_output":true,"text":"design of randomised, double-blind, placebo-controlled trial. Curr Med Res Opin 2012","text_display":" design of randomised, double-blind, placebo-controlled trial. Curr Med Res Opin 2012","confidence":1,"confidence_rate":1},{"cnt":[[387,889],[681,889],[681,939],[387,939]],"region":{"top_left_x":386,"top_left_y":889,"width":296,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"289085c5c06f47efbb2404af277c46fe","type":"text","conversion_output":true,"text":"Feb;28(2):231-9.","text_display":" Feb;28(2):231-9.","confidence":1,"confidence_rate":1},{"cnt":[[249,958],[1863,958],[1863,1010],[249,1010]],"region":{"top_left_x":249,"top_left_y":958,"width":1614,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a5fde7de154445e8aa48e3ddd6a4151","type":"text","conversion_output":true,"text":"18. Peterfy CG, Guermazi A, Zaim S, Tirman PFJ, Miaux Y, et al. Whole-Organ Magnetic","text_display":"\n18. Peterfy CG, Guermazi A, Zaim S, Tirman PFJ, Miaux Y, et al. Whole-Organ Magnetic","confidence":1,"confidence_rate":1},{"cnt":[[387,1008],[1863,1008],[1863,1059],[387,1059]],"region":{"top_left_x":386,"top_left_y":1007,"width":1477,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"360dbe232e8445e29930c6a47304ec93","type":"text","conversion_output":true,"text":"Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis","text_display":" Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis","confidence":1,"confidence_rate":1},{"cnt":[[387,1057],[838,1057],[838,1106],[387,1106]],"region":{"top_left_x":386,"top_left_y":1057,"width":452,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0d732aa0dbf429195bedfdf19006d2a","type":"text","conversion_output":true,"text":"Cartilage 2004;12:177-90.","text_display":" Cartilage 2004;12:177-90.","confidence":1,"confidence_rate":1},{"cnt":[[247,1124],[1863,1124],[1863,1175],[247,1175]],"region":{"top_left_x":247,"top_left_y":1123,"width":1616,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4afbaec9c82b43c790dfc0ba15fbb18a","type":"text","conversion_output":true,"text":"19. Adams JG, MacAlindon T, Dimasi M, Carey J, Eustace S. Contribution of meniscal","text_display":"\n19. Adams JG, MacAlindon T, Dimasi M, Carey J, Eustace S. Contribution of meniscal","confidence":1,"confidence_rate":1},{"cnt":[[387,1173],[1863,1173],[1863,1222],[387,1222]],"region":{"top_left_x":386,"top_left_y":1173,"width":1477,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b276094b6a6545b2bfc82a4f3a346612","type":"text","conversion_output":true,"text":"extrusion and cartilage loss to joint space narrowing in osteoarthritis. Clin Radiol","text_display":" extrusion and cartilage loss to joint space narrowing in osteoarthritis. Clin Radiol","confidence":1,"confidence_rate":1},{"cnt":[[391,1220],[700,1220],[700,1270],[391,1270]],"region":{"top_left_x":391,"top_left_y":1220,"width":310,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66a147024149425dafde551f3199728c","type":"text","conversion_output":true,"text":"1999;54(8):502-6.","text_display":" 1999;54(8):502-6.","confidence":1,"confidence_rate":1},{"cnt":[[245,1289],[1863,1289],[1863,1338],[245,1338]],"region":{"top_left_x":244,"top_left_y":1289,"width":1619,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2382383d2e814fdaa85ea2fe1cb0aea2","type":"text","conversion_output":true,"text":"20. U.S. Department of Health and Human Services. Guidance for Industry: Clinical","text_display":"\n20. U.S. Department of Health and Human Services. Guidance for Industry: Clinical","confidence":1,"confidence_rate":1},{"cnt":[[387,1336],[1863,1336],[1863,1386],[387,1386]],"region":{"top_left_x":386,"top_left_y":1336,"width":1477,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3487008715ff4115be30840fe1313d4b","type":"text","conversion_output":true,"text":"Development Programs for Drugs, Devices, and Biological Products Intended for the","text_display":" Development Programs for Drugs, Devices, and Biological Products Intended for the","confidence":1,"confidence_rate":1},{"cnt":[[387,1384],[1601,1384],[1601,1433],[387,1433]],"region":{"top_left_x":386,"top_left_y":1383,"width":1215,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53ce18e9725a4f67ac57337c55e3ee86","type":"text","conversion_output":true,"text":"Treatment of Osteoarthritis (OA). Food and Drug Administration; 1999.","text_display":" Treatment of Osteoarthritis (OA). Food and Drug Administration; 1999.","confidence":1,"confidence_rate":1},{"cnt":[[245,1452],[1863,1452],[1863,1504],[245,1504]],"region":{"top_left_x":244,"top_left_y":1452,"width":1619,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"976fcb158a5a4e7d93167f57d763b21c","type":"text","conversion_output":true,"text":"21. Peterfy C, Li J, Zaim S, Duryea J, Lynch J, Miaux Y, et al. Comparison of fixed-","text_display":"\n21. Peterfy C, Li J, Zaim S, Duryea J, Lynch J, Miaux Y, et al. Comparison of fixed","confidence":1,"confidence_rate":1},{"cnt":[[387,1500],[1863,1500],[1863,1553],[387,1553]],"region":{"top_left_x":386,"top_left_y":1499,"width":1477,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea2e39f23a484a26b0a999e3af33ce9b","type":"text","conversion_output":true,"text":"flexion positioning with fluoroscopic semi-flexed positioning for quantifying","text_display":"flexion positioning with fluoroscopic semi-flexed positioning for quantifying","confidence":1,"confidence_rate":1},{"cnt":[[387,1551],[1863,1551],[1863,1601],[387,1601]],"region":{"top_left_x":386,"top_left_y":1551,"width":1477,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43ce6338fdf048208db502286a31110f","type":"text","conversion_output":true,"text":"radiographic joint space width in the knee: test-retest reproducibility. Skeletal Radiol","text_display":" radiographic joint space width in the knee: test-retest reproducibility. Skeletal Radiol","confidence":1,"confidence_rate":1},{"cnt":[[387,1594],[724,1594],[724,1648],[387,1648]],"region":{"top_left_x":386,"top_left_y":1594,"width":339,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e3626f267ea4cd4962b2e06332b95b6","type":"text","conversion_output":true,"text":"2003;32(3):128-32.","text_display":" 2003;32(3):128-32.","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[1863,1667],[1863,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1667,"width":1619,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f41441c2a5604f7a9a35da6e4440c2f7","type":"text","conversion_output":true,"text":"22. Committee for Medicinal Products for Human use. Guideline on Clinical Investigation","text_display":"\n22. Committee for Medicinal Products for Human use. Guideline on Clinical Investigation","confidence":1,"confidence_rate":1},{"cnt":[[387,1714],[1863,1714],[1863,1764],[387,1764]],"region":{"top_left_x":386,"top_left_y":1714,"width":1477,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c46e7ece38834a6487f991eb8bce9785","type":"text","conversion_output":true,"text":"of Medicinal Products Used in the Treatment of Osteoarthritis. European Medicines","text_display":" of Medicinal Products Used in the Treatment of Osteoarthritis. European Medicines","confidence":1,"confidence_rate":1},{"cnt":[[387,1762],[642,1762],[642,1811],[387,1811]],"region":{"top_left_x":386,"top_left_y":1761,"width":257,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a393609ea0194f6f937f6cf222308965","type":"text","conversion_output":true,"text":"Agency; 2010.","text_display":" Agency; 2010.","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[1863,1830],[1863,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1830,"width":1619,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e493cab861254e45882fac63ed19fdb2","type":"text","conversion_output":true,"text":"23. Chevalier X, Giraudeau B, Conrozier T, Marliere J, Kiefer P, Goupille P. Safety study","text_display":"\n23. Chevalier X, Giraudeau B, Conrozier T, Marliere J, Kiefer P, Goupille P. Safety study","confidence":1,"confidence_rate":1},{"cnt":[[387,1878],[1863,1878],[1863,1927],[387,1927]],"region":{"top_left_x":386,"top_left_y":1877,"width":1477,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71bf055b791f45299423c52b2b94f85e","type":"text","conversion_output":true,"text":"of intraarticular injection of interleukin 1 receptor antagonist in patients with painful","text_display":" of intraarticular injection of interleukin 1 receptor antagonist in patients with painful","confidence":0.9985356330871582,"confidence_rate":0.9999848924837492},{"cnt":[[387,1925],[1635,1925],[1635,1979],[387,1979]],"region":{"top_left_x":386,"top_left_y":1925,"width":1249,"height":54},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"533c4bb78a964fc7bde3c83a8eb81298","type":"text","conversion_output":true,"text":"knee osteoarthritis: a multicenter study. J Rheumatol 2005;32(7):1317-23.","text_display":" knee osteoarthritis: a multicenter study. J Rheumatol 2005;32(7):1317-23.","confidence":0.99951171875,"confidence_rate":0.9999937384747559},{"cnt":[[245,1996],[1863,1996],[1863,2047],[245,2047]],"region":{"top_left_x":244,"top_left_y":1995,"width":1619,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0ddbc0490be4dc3a54a4da833d19566","type":"text","conversion_output":true,"text":"24. Felson DT, Lynch J, Guermazi A, Roemer FW, Niu J, et al. Comparison of BLOKS","text_display":"\n24. Felson DT, Lynch J, Guermazi A, Roemer FW, Niu J, et al. Comparison of BLOKS","confidence":1,"confidence_rate":1},{"cnt":[[387,2041],[1863,2039],[1863,2093],[387,2095]],"region":{"top_left_x":386,"top_left_y":2039,"width":1477,"height":56},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d341be3ec34477bafea7c925314482f","type":"text","conversion_output":true,"text":"and WORMS scoring systems part II. Longitudinal assessment of knee MRIs for","text_display":" and WORMS scoring systems part II. Longitudinal assessment of knee MRIs for","confidence":1,"confidence_rate":1},{"cnt":[[387,2093],[1863,2093],[1863,2142],[387,2142]],"region":{"top_left_x":386,"top_left_y":2092,"width":1477,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b6054a277004b688c62c57356b52166","type":"text","conversion_output":true,"text":"osteoarthritis and suggested approach based on their performance: data from the","text_display":" osteoarthritis and suggested approach based on their performance: data from the","confidence":1,"confidence_rate":1},{"cnt":[[387,2140],[1553,2140],[1553,2189],[387,2189]],"region":{"top_left_x":386,"top_left_y":2139,"width":1168,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4cfc4b31bc5142afabf2af6d7c909687","type":"text","conversion_output":true,"text":"Osteoarthritis Initiative. Osteoarthritis Cartilage 2010;18(11):1402-7.","text_display":" Osteoarthritis Initiative. Osteoarthritis Cartilage 2010;18(11):1402-7.","confidence":0.99951171875,"confidence_rate":0.9999935736983052},{"cnt":[[245,2209],[1861,2209],[1861,2258],[245,2258]],"region":{"top_left_x":244,"top_left_y":2208,"width":1617,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2dcd50407f184edface58f1a6109c1cb","type":"text","conversion_output":true,"text":"25. Lynch JA, Roemer FW, Nevitt MC, Felson DT, Niu J, et al. Comparison of BLOKS","text_display":"\n25. Lynch JA, Roemer FW, Nevitt MC, Felson DT, Niu J, et al. Comparison of BLOKS","confidence":1,"confidence_rate":1},{"cnt":[[387,2256],[1863,2256],[1863,2305],[387,2305]],"region":{"top_left_x":386,"top_left_y":2255,"width":1477,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9928004f4c04430e8ac88b455fb475e2","type":"text","conversion_output":true,"text":"and WORMS scoring systems part I. Cross sectional comparison of methods to assess","text_display":" and WORMS scoring systems part I. Cross sectional comparison of methods to assess","confidence":1,"confidence_rate":1},{"cnt":[[387,2303],[1863,2303],[1863,2353],[387,2353]],"region":{"top_left_x":386,"top_left_y":2303,"width":1477,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af5b890151ae4a0fa512ea8026435589","type":"text","conversion_output":true,"text":"cartilage morphology, meniscal damage and bone marrow lesions on knee MRI: data","text_display":" cartilage morphology, meniscal damage and bone marrow lesions on knee MRI: data","confidence":1,"confidence_rate":1},{"cnt":[[387,2350],[1738,2350],[1738,2400],[387,2400]],"region":{"top_left_x":386,"top_left_y":2350,"width":1353,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f392d73aa71945868438dde6a2520e00","type":"text","conversion_output":true,"text":"from the osteoarthritis initiative. Osteoarthritis Cartilage 2010;18(11):1393-401.","text_display":" from the osteoarthritis initiative. Osteoarthritis Cartilage 2010;18(11):1393-401.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"43d30e38549f4d7c99d8f2ba6828f70c","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5d930028dc0949f1a00602aba0aafb68","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1491,2531],[1596,2531],[1596,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2530,"width":106,"height":34},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7982980b80b34548b3f6e7d60d6db1ae","type":"page_info","conversion_output":false,"text":"101/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-102","page":102,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0823bc5039da40cbb088086beba9ce44","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73ffbd245fc046a8b8be3de707babe25","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a52bae29309f485bb6b43aa5d072f82e","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,301],[1867,301],[1867,350],[245,350]],"region":{"top_left_x":244,"top_left_y":300,"width":1623,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67c24b8fc90b4c3f9a70c91d0b2de532","type":"text","conversion_output":true,"text":"26. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of","text_display":"\n26. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of","confidence":1,"confidence_rate":1},{"cnt":[[387,348],[1863,348],[1863,400],[387,400]],"region":{"top_left_x":386,"top_left_y":348,"width":1477,"height":52},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a53e1cd8cc14164b3aedfbaa0d3d620","type":"text","conversion_output":true,"text":"WOMAC: a health status instrument for measuring clinically important patient relevant","text_display":" WOMAC: a health status instrument for measuring clinically important patient relevant","confidence":1,"confidence_rate":1},{"cnt":[[387,397],[1863,397],[1863,449],[387,449]],"region":{"top_left_x":386,"top_left_y":397,"width":1477,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a30d17acec634fbd962dfb2c323141a7","type":"text","conversion_output":true,"text":"outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or","text_display":" outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or","confidence":1,"confidence_rate":1},{"cnt":[[387,447],[1085,447],[1085,496],[387,496]],"region":{"top_left_x":386,"top_left_y":446,"width":699,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b84f54d86c1642b68d29dc034f9f96aa","type":"text","conversion_output":true,"text":"knee. J Rheumatol 1988;15(12):1833-40.","text_display":" knee. J Rheumatol 1988;15(12):1833-40.","confidence":0.9853515625,"confidence_rate":0.9996568778276527},{"cnt":[[245,511],[1863,511],[1863,565],[245,565]],"region":{"top_left_x":244,"top_left_y":511,"width":1619,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a91b74e4ee634e6b84d239dfa6ae1824","type":"text","conversion_output":true,"text":"27. Tubach F, Ravaud P, Baron G, et al. Evaluation of clinically relevant changes in","text_display":"\n27. Tubach F, Ravaud P, Baron G, et al. Evaluation of clinically relevant changes in","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[387,561],[1863,561],[1863,612],[387,612]],"region":{"top_left_x":386,"top_left_y":560,"width":1477,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19b73f2b647043bb838d47945ed58da0","type":"text","conversion_output":true,"text":"patient reported outcomes in knee and hip osteoarthritis: the minimal clinically","text_display":" patient reported outcomes in knee and hip osteoarthritis: the minimal clinically","confidence":1,"confidence_rate":1},{"cnt":[[387,610],[1351,610],[1351,660],[387,660]],"region":{"top_left_x":386,"top_left_y":610,"width":966,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7c0f02369a34ce482101c1668887c5f","type":"text","conversion_output":true,"text":"important improvement. Ann Rheum Dis 2005;64:29-33.","text_display":" important improvement. Ann Rheum Dis 2005;64:29-33.","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[245,677],[1863,677],[1863,728],[245,728]],"region":{"top_left_x":244,"top_left_y":676,"width":1619,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1c96deb157a4354bec9de07e297280d","type":"text","conversion_output":true,"text":"28. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis","text_display":"\n28. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis","confidence":1,"confidence_rate":1},{"cnt":[[391,726],[694,726],[694,776],[391,776]],"region":{"top_left_x":391,"top_left_y":726,"width":303,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a6442d2830649398b2592d47b80b18d","type":"text","conversion_output":true,"text":"1957;16:494-502.","text_display":" 1957;16:494-502.","confidence":1,"confidence_rate":1},{"cnt":[[243,795],[1863,795],[1863,846],[243,846]],"region":{"top_left_x":242,"top_left_y":794,"width":1621,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6da29497d4ad4080bc616510cfe858e8","type":"text","conversion_output":true,"text":"29. Kellgren JH, Lawrence JS. Atlas of standard radiographs: the epidemiology of chronic","text_display":"\n29. Kellgren JH, Lawrence JS. Atlas of standard radiographs: the epidemiology of chronic","confidence":1,"confidence_rate":1},{"cnt":[[387,842],[1480,842],[1480,892],[387,892]],"region":{"top_left_x":386,"top_left_y":842,"width":1095,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61c6a553b00a43178548c7d172a06dde","type":"text","conversion_output":true,"text":"rheumatism, vol. 2. Oxford: Blackwell Scientific, 1963. iv47-55.","text_display":" rheumatism, vol. 2. Oxford: Blackwell Scientific, 1963. iv47-55.","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1863,911],[1863,965],[245,965]],"region":{"top_left_x":244,"top_left_y":910,"width":1619,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ade18c6efbc84d23abf844a9a69abf2a","type":"text","conversion_output":true,"text":"30. Simonsick EM, Gardner AW, Poehlman ET.Assessment of physical function and","text_display":"\n30. Simonsick EM, Gardner AW, Poehlman ET.Assessment of physical function and","confidence":1,"confidence_rate":1},{"cnt":[[387,958],[1861,958],[1861,1010],[387,1010]],"region":{"top_left_x":386,"top_left_y":958,"width":1475,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e80a1531784e47b8aae0075d144b1741","type":"text","conversion_output":true,"text":"exercise tolerance in older adults: reproducibility and comparability of five measures.","text_display":" exercise tolerance in older adults: reproducibility and comparability of five measures.","confidence":1,"confidence_rate":1},{"cnt":[[387,1005],[1079,1005],[1079,1059],[387,1059]],"region":{"top_left_x":386,"top_left_y":1005,"width":693,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f7d7023fc1149e998be0c569716e818","type":"text","conversion_output":true,"text":"Aging (Milano) 2000 Aug;12(4):274-80.","text_display":" Aging (Milano) 2000 Aug;12(4):274-80.","confidence":0.9912216663360596,"confidence_rate":0.9998040838559958},{"cnt":[[245,1076],[1863,1076],[1863,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1076,"width":1619,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf8ae0164e94457ab461c95517034848","type":"text","conversion_output":true,"text":"31. Marks R. Reliability and validity of self-paced walking time measures for knee","text_display":"\n31. Marks R. Reliability and validity of self-paced walking time measures for knee","confidence":1,"confidence_rate":1},{"cnt":[[387,1126],[1214,1126],[1214,1175],[387,1175]],"region":{"top_left_x":386,"top_left_y":1125,"width":828,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d910b3af15342f9ac6787c436278fbc","type":"text","conversion_output":true,"text":"osteoarthritis. Arthritis Care Res 1994;7(1):50-3.","text_display":" osteoarthritis. Arthritis Care Res 1994;7(1):50-3.","confidence":0.99951171875,"confidence_rate":0.9999911200303706},{"cnt":[[245,1195],[1861,1195],[1861,1244],[245,1244]],"region":{"top_left_x":244,"top_left_y":1194,"width":1617,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc255f8ac84b4a59bde57f12e3677ebc","type":"text","conversion_output":true,"text":"32. Berkoff DJ, Miller LE, Block JE. Clinical utility of ultrasound guidance for intra-","text_display":"\n32. Berkoff DJ, Miller LE, Block JE. Clinical utility of ultrasound guidance for intra","confidence":1,"confidence_rate":1},{"cnt":[[387,1242],[1525,1242],[1525,1291],[387,1291]],"region":{"top_left_x":386,"top_left_y":1241,"width":1140,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49c663c53c8741a28cb93c312bc8fb68","type":"text","conversion_output":true,"text":"articular knee injections: a review. Clin Interv Aging 2012;7:89-95.","text_display":"articular knee injections: a review. Clin Interv Aging 2012;7:89-95.","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1863,1311],[1863,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1310,"width":1619,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5e89d2d36dc419abddad70d142e2175","type":"text","conversion_output":true,"text":"33. Roos EM, Lohmander LS. The Knee Injury and Osteoarthritis Outcome Score","text_display":"\n33. Roos EM, Lohmander LS. The Knee Injury and Osteoarthritis Outcome Score","confidence":1,"confidence_rate":1},{"cnt":[[387,1358],[1781,1358],[1781,1407],[387,1407]],"region":{"top_left_x":386,"top_left_y":1357,"width":1396,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c41ed75e8abc47debf5c260276ad97cc","type":"text","conversion_output":true,"text":"(KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes 2003;1:64.","text_display":" (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes 2003;1:64.","confidence":0.9990234375,"confidence_rate":0.9999886391383975},{"cnt":[[245,1427],[1863,1427],[1863,1476],[245,1476]],"region":{"top_left_x":244,"top_left_y":1426,"width":1619,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66d6764e935d423eba4b36dadaa77a57","type":"text","conversion_output":true,"text":"34. Roos EM, Toksvig-Larsen S. Knee Injury and Osteoarthritis Outcome Score (KOOS) -","text_display":"\n34. Roos EM, Toksvig-Larsen S. Knee Injury and Osteoarthritis Outcome Score (KOOS) ","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[387,1474],[1863,1474],[1863,1523],[387,1523]],"region":{"top_left_x":386,"top_left_y":1473,"width":1477,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f389932edfe4f5a86c152e76cef6db6","type":"text","conversion_output":true,"text":"validation and comparison to the WOMAC in total knee replacement. Health Qual Life","text_display":"validation and comparison to the WOMAC in total knee replacement. Health Qual Life","confidence":1,"confidence_rate":1},{"cnt":[[387,1521],[758,1521],[758,1571],[387,1571]],"region":{"top_left_x":386,"top_left_y":1521,"width":373,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eef7ed13bdbc4a31805b6a4a6b5d6a04","type":"text","conversion_output":true,"text":"Outcomes 2003;1:17.","text_display":" Outcomes 2003;1:17.","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[1863,1590],[1863,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1589,"width":1619,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d482349f4e54ccf9ab5926888afc43d","type":"text","conversion_output":true,"text":"35. Kosinski M, Zhao SZ, Dedhiya S, Osterhaus JT, Ware JE, Jr. Determining minimally","text_display":"\n35. Kosinski M, Zhao SZ, Dedhiya S, Osterhaus JT, Ware JE, Jr. Determining minimally","confidence":1,"confidence_rate":1},{"cnt":[[387,1639],[1863,1639],[1863,1691],[387,1691]],"region":{"top_left_x":386,"top_left_y":1639,"width":1477,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abb320137fd743a7b5d70fba6ca80ac9","type":"text","conversion_output":true,"text":"important changes in generic and disease-specific health-related quality of life","text_display":" important changes in generic and disease-specific health-related quality of life","confidence":1,"confidence_rate":1},{"cnt":[[387,1687],[1863,1687],[1863,1738],[387,1738]],"region":{"top_left_x":386,"top_left_y":1686,"width":1477,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c9e9298935d42e7b05b20aeabdeba71","type":"text","conversion_output":true,"text":"questionnaires in clinical trials of rheumatoid arthritis. Arthritis Rheum","text_display":" questionnaires in clinical trials of rheumatoid arthritis. Arthritis Rheum","confidence":0.99951171875,"confidence_rate":0.999993817734324},{"cnt":[[387,1732],[746,1732],[746,1783],[387,1783]],"region":{"top_left_x":386,"top_left_y":1731,"width":360,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3858bf475bc04eaa82f4762fafab7cc7","type":"text","conversion_output":true,"text":"2000;43(7):1478-87.","text_display":" 2000;43(7):1478-87.","confidence":0.9990234375,"confidence_rate":0.999959290843314},{"cnt":[[245,1800],[1863,1800],[1863,1850],[245,1850]],"region":{"top_left_x":244,"top_left_y":1800,"width":1619,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9a635d12d5c4bfbaea8e39ee6e7812f","type":"text","conversion_output":true,"text":"36. Hawker G. Measure of Intermittent and Constant Osteoarthritis Pain: ICOAP. User's","text_display":"\n36. Hawker G. Measure of Intermittent and Constant Osteoarthritis Pain: ICOAP. User's","confidence":1,"confidence_rate":1},{"cnt":[[387,1852],[612,1852],[612,1897],[387,1897]],"region":{"top_left_x":386,"top_left_y":1851,"width":227,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30b3bfa6dc4a42679c647ee5c8dd7504","type":"text","conversion_output":true,"text":"Guide. 2010.","text_display":" Guide. 2010.","confidence":0.9873106479644775,"confidence_rate":0.9992021591013296},{"cnt":[[245,1921],[1863,1921],[1863,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1920,"width":1619,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e9b86670d2a461ebc16f249b846a747","type":"text","conversion_output":true,"text":"37. Maillefert JF, Kloppenburg M, Fernandes L, Punz L, Gunther KP, et al. Multi-","text_display":"\n37. Maillefert JF, Kloppenburg M, Fernandes L, Punz L, Gunther KP, et al. Multi","confidence":1,"confidence_rate":1},{"cnt":[[387,1968],[1867,1968],[1867,2017],[387,2017]],"region":{"top_left_x":386,"top_left_y":1967,"width":1481,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"415bb800ce994cc6b37706783f56651c","type":"text","conversion_output":true,"text":"language translation and cross-cultural adaption of the OARSI/OMERACT measure of","text_display":"language translation and cross-cultural adaption of the OARSI/OMERACT measure of","confidence":1,"confidence_rate":1},{"cnt":[[387,2015],[1863,2015],[1863,2069],[387,2069]],"region":{"top_left_x":386,"top_left_y":2015,"width":1477,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51543acc66174a788098834698226ba0","type":"text","conversion_output":true,"text":"intermittent and constant osteoarthritis pain (ICOAP). Osteoarthritis Cartilage","text_display":" intermittent and constant osteoarthritis pain (ICOAP). Osteoarthritis Cartilage","confidence":1,"confidence_rate":1},{"cnt":[[387,2065],[675,2065],[675,2112],[387,2112]],"region":{"top_left_x":386,"top_left_y":2064,"width":289,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b23d9566c59849c38e1f5ff89ffde99f","type":"text","conversion_output":true,"text":"2009;17:1293-6.","text_display":" 2009;17:1293-6.","confidence":1,"confidence_rate":1},{"cnt":[[245,2131],[1863,2131],[1863,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2131,"width":1619,"height":54},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bee9b4fea5e6468fb0ddd8a5ceca2476","type":"text","conversion_output":true,"text":"38. Davis AM, Lohmander LS, Wong R, Venkataramanan V, Hawker GA. Evaluating the","text_display":"\n38. Davis AM, Lohmander LS, Wong R, Venkataramanan V, Hawker GA. Evaluating the","confidence":1,"confidence_rate":1},{"cnt":[[387,2179],[1863,2179],[1863,2232],[387,2232]],"region":{"top_left_x":386,"top_left_y":2178,"width":1477,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8dd06ebaf5a4bc7b271a0bd86e8d5cb","type":"text","conversion_output":true,"text":"responsiveness of the ICOAP following hip or knee replacement. Osteoarthritis","text_display":" responsiveness of the ICOAP following hip or knee replacement. Osteoarthritis","confidence":1,"confidence_rate":1},{"cnt":[[387,2230],[838,2230],[838,2279],[387,2279]],"region":{"top_left_x":386,"top_left_y":2230,"width":452,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c222f9564f4485b8754c8f76cff352f","type":"text","conversion_output":true,"text":"Cartilage 2010;18:1043-5.","text_display":" Cartilage 2010;18:1043-5.","confidence":1,"confidence_rate":1},{"cnt":[[245,2299],[1863,2299],[1863,2348],[245,2348]],"region":{"top_left_x":244,"top_left_y":2298,"width":1619,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b296035b22f8492f9d3c8ad516520970","type":"text","conversion_output":true,"text":"39. Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W. Minimal clinically important","text_display":"\n39. Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W. Minimal clinically important","confidence":1,"confidence_rate":1},{"cnt":[[387,2346],[1863,2346],[1863,2396],[387,2396]],"region":{"top_left_x":386,"top_left_y":2346,"width":1477,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76b89221db294c69ade31db89c800b03","type":"text","conversion_output":true,"text":"changes in chronic musculoskeletal pain intensity measured on a numerical rating","text_display":" changes in chronic musculoskeletal pain intensity measured on a numerical rating","confidence":1,"confidence_rate":1},{"cnt":[[387,2393],[988,2393],[988,2443],[387,2443]],"region":{"top_left_x":386,"top_left_y":2393,"width":603,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b0092bb7e32417dbcbd2892e38a3200","type":"text","conversion_output":true,"text":"scale. Eur J Pain 2004;8(4):283-91.","text_display":" scale. Eur J Pain 2004;8(4):283-91.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"63d53af8e8f5452d9f3cb5c5b00bcead","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"990d7a097aac4f46a550b639cf7d9982","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[1491,2531],[1601,2531],[1601,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2530,"width":110,"height":34},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5dd4c6a9181944ce9a075b643a5dae90","type":"page_info","conversion_output":false,"text":"102/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-103","page":103,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0f7200541964f33a22d6cc1f9bf9997","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"356c974235f547cf8c8fe9e1d308f602","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03e7499184aa47ca8f15eb504117fe3e","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,299],[1863,299],[1863,350],[243,350]],"region":{"top_left_x":242,"top_left_y":298,"width":1621,"height":53},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2eb6ae9a38fc464b8572bf1d8da84146","type":"text","conversion_output":true,"text":"40. Dworkin RH, Turk DC, Farrar JT, Haythornthwaite JA, Jensen MP, et al. Core","text_display":"\n40. Dworkin RH, Turk DC, Farrar JT, Haythornthwaite JA, Jensen MP, et al. Core","confidence":1,"confidence_rate":1},{"cnt":[[387,348],[1863,348],[1863,402],[387,402]],"region":{"top_left_x":386,"top_left_y":348,"width":1477,"height":54},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eba96244def04b62ba349bb7dd343236","type":"text","conversion_output":true,"text":"outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain","text_display":" outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain","confidence":1,"confidence_rate":1},{"cnt":[[387,397],[737,397],[737,449],[387,449]],"region":{"top_left_x":386,"top_left_y":397,"width":351,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df201093153d490da1a4317a474fd855","type":"text","conversion_output":true,"text":"2005;113(1-2):9-19.","text_display":" 2005;113(1-2):9-19.","confidence":1,"confidence_rate":1},{"cnt":[[245,464],[1861,464],[1861,518],[245,518]],"region":{"top_left_x":244,"top_left_y":464,"width":1617,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b96c8618afd44f5b676c2d6c956eb73","type":"text","conversion_output":true,"text":"41. Veenhof C, Bijlsma JW, van den Ende CH, van Dijk GM, Pisters MF, Dekker J.","text_display":"\n41. Veenhof C, Bijlsma JW, van den Ende CH, van Dijk GM, Pisters MF, Dekker J.","confidence":1,"confidence_rate":1},{"cnt":[[387,516],[1863,516],[1863,565],[387,565]],"region":{"top_left_x":386,"top_left_y":515,"width":1477,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cffe8c3ebb7b417291bcd344646f7df1","type":"text","conversion_output":true,"text":"Psychometric evaluation of osteoarthritis questionnaires: a systematic review of the","text_display":" Psychometric evaluation of osteoarthritis questionnaires: a systematic review of the","confidence":1,"confidence_rate":1},{"cnt":[[387,563],[1177,563],[1177,612],[387,612]],"region":{"top_left_x":386,"top_left_y":562,"width":792,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76c76334f5634f4287de76c1ce6a8bb7","type":"text","conversion_output":true,"text":"literature. Arthritis Rheum 2006;55(3):480-92.","text_display":" literature. Arthritis Rheum 2006;55(3):480-92.","confidence":1,"confidence_rate":1},{"cnt":[[245,629],[1858,629],[1858,681],[245,681]],"region":{"top_left_x":244,"top_left_y":629,"width":1615,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddae334226464e069c781f50b07155e7","type":"text","conversion_output":true,"text":"42. Breivik H, Borchgrevink PC, Allen SM, Rosseland LA, Romundstad L, et al.","text_display":"\n42. Breivik H, Borchgrevink PC, Allen SM, Rosseland LA, Romundstad L, et al.","confidence":1,"confidence_rate":1},{"cnt":[[387,679],[1293,679],[1293,728],[387,728]],"region":{"top_left_x":386,"top_left_y":678,"width":908,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"613959b3203f4274a1b58a69df3161fc","type":"text","conversion_output":true,"text":"Assessment of pain. Br J Anaesth 2008;101(1):17-24.","text_display":" Assessment of pain. Br J Anaesth 2008;101(1):17-24.","confidence":0.9926848383620381,"confidence_rate":0.9998689005829419},{"cnt":[[245,748],[1863,748],[1863,797],[245,797]],"region":{"top_left_x":244,"top_left_y":747,"width":1619,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bfc164dad9d4728a58f2c5dc661577a","type":"text","conversion_output":true,"text":"43. Ware JE, Jr., Kosinski M, Dewey JE. How to score version 2 of the SF-36 health","text_display":"\n43. Ware JE, Jr., Kosinski M, Dewey JE. How to score version 2 of the SF-36 health","confidence":1,"confidence_rate":1},{"cnt":[[387,795],[711,795],[711,844],[387,844]],"region":{"top_left_x":386,"top_left_y":794,"width":326,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5920b9a20984bacbdd86aba81b84e2f","type":"text","conversion_output":true,"text":"survey. 3 ed. 2000.","text_display":" survey. 3 ed. 2000.","confidence":1,"confidence_rate":1},{"cnt":[[245,864],[1863,864],[1863,913],[245,913]],"region":{"top_left_x":244,"top_left_y":863,"width":1619,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a04700c69694f888e4a2d721112dcd1","type":"text","conversion_output":true,"text":"44. Abramson SB, Berenbaum F, Hochberg MC, Moskowitz RW. Introduction to OARSI","text_display":"\n44. Abramson SB, Berenbaum F, Hochberg MC, Moskowitz RW. Introduction to OARSI","confidence":1,"confidence_rate":1},{"cnt":[[387,911],[1714,911],[1714,960],[387,960]],"region":{"top_left_x":386,"top_left_y":910,"width":1329,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5deaa9a14228480cb5d688a0ad88ee10","type":"text","conversion_output":true,"text":"FDA initiative OAC special edition. Osteoarthritis Cartilage 2011;19(5):475-7.","text_display":" FDA initiative OAC special edition. Osteoarthritis Cartilage 2011;19(5):475-7.","confidence":1,"confidence_rate":1},{"cnt":[[245,980],[1861,980],[1861,1029],[245,1029]],"region":{"top_left_x":244,"top_left_y":979,"width":1617,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"251891beddf347d5b862e4e20d7de4b4","type":"text","conversion_output":true,"text":"45. Hellio le Graverand MP, Clemmer RS, Redifer P, Brunell RM, Hayes CW, Brandt KD,","text_display":"\n45. Hellio le Graverand MP, Clemmer RS, Redifer P, Brunell RM, Hayes CW, Brandt KD,","confidence":1,"confidence_rate":1},{"cnt":[[387,1027],[1863,1027],[1863,1079],[387,1079]],"region":{"top_left_x":386,"top_left_y":1026,"width":1477,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17caf5e0a6fa43208b8355715b8890da","type":"text","conversion_output":true,"text":"Abramson SB, Manning PT, Miller CG, Vignon Eet al. A 2-year randomised, double-","text_display":" Abramson SB, Manning PT, Miller CG, Vignon Eet al. A 2-year randomised, double","confidence":0.9820137023925781,"confidence_rate":0.9997839517088366},{"cnt":[[387,1076],[1861,1076],[1861,1128],[387,1128]],"region":{"top_left_x":386,"top_left_y":1076,"width":1475,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a964cf37b964e0fb6e0fee23b0a14bc","type":"text","conversion_output":true,"text":"blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor,","text_display":"blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor,","confidence":1,"confidence_rate":1},{"cnt":[[387,1126],[1863,1126],[1863,1175],[387,1175]],"region":{"top_left_x":386,"top_left_y":1125,"width":1477,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"748c5e79c93b40e09673d24cfa7065f1","type":"text","conversion_output":true,"text":"cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann","text_display":" cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann","confidence":1,"confidence_rate":1},{"cnt":[[389,1173],[922,1173],[922,1222],[389,1222]],"region":{"top_left_x":388,"top_left_y":1173,"width":534,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1736fb805cf4ffe8d810aaf083b500c","type":"text","conversion_output":true,"text":"Rheum Dis 2013;72(2): 187-95.","text_display":" Rheum Dis 2013;72(2): 187-95.","confidence":0.5361671447753906,"confidence_rate":0.9818343930830545},{"cnt":[[245,1242],[1863,1242],[1863,1291],[245,1291]],"region":{"top_left_x":244,"top_left_y":1241,"width":1619,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d6c08a112264786a12b93159dcface9","type":"text","conversion_output":true,"text":"46. Wang Y, Hall S, Hanna F, Wluka AE, Grant G, Marks P, et al. Effects of Hylan G-F 20","text_display":"\n46. Wang Y, Hall S, Hanna F, Wluka AE, Grant G, Marks P, et al. Effects of Hylan G-F 20","confidence":1,"confidence_rate":1},{"cnt":[[387,1289],[1863,1289],[1863,1338],[387,1338]],"region":{"top_left_x":386,"top_left_y":1289,"width":1477,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"669dc6d8c3d846ad9eaf95face7fa232","type":"text","conversion_output":true,"text":"supplementation on cartilage preservation detected by magnetic resonance imaging in","text_display":" supplementation on cartilage preservation detected by magnetic resonance imaging in","confidence":1,"confidence_rate":1},{"cnt":[[387,1336],[1863,1336],[1863,1386],[387,1386]],"region":{"top_left_x":386,"top_left_y":1336,"width":1477,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e6e68eaa3e64a9b9fed1a0e913cd87d","type":"text","conversion_output":true,"text":"osteoarthritis of the knee: a two-year single-blind clinical trial. BMC Musculoskelet","text_display":" osteoarthritis of the knee: a two-year single-blind clinical trial. BMC Musculoskelet","confidence":1,"confidence_rate":1},{"cnt":[[387,1384],[741,1384],[741,1433],[387,1433]],"region":{"top_left_x":386,"top_left_y":1383,"width":356,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8db6a497ec824d3cab4cf3a80feba033","type":"text","conversion_output":true,"text":"Disord 2011;12:195.","text_display":" Disord 2011;12:195.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"abe7ae96a63f49a68638997cff2c6b9b","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d5a417de8a474681aa335596affa2e53","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1491,2529],[1601,2529],[1601,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2528,"width":110,"height":36},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"798b37d1c2254d5f8964ed0e9e77592b","type":"page_info","conversion_output":false,"text":"103/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-104","page":104,"lines":[{"cnt":[[245,129],[434,129],[434,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":190,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a3f4730a19748a492f678150031c312","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89ffdecb86224ed0845c92ad949adecf","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1624a513458440c5ad975966e612b83f","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,322],[307,322],[307,376],[243,376]],"region":{"top_left_x":242,"top_left_y":322,"width":66,"height":54},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3328de4821c6489fb503744b0883aa6a","type":"section_header","conversion_output":false,"children_ids":["b1192bfd75974ec8988bec782db25e98"],"text":"","text_display":""},{"cnt":[[243,327],[305,327],[305,374],[243,374]],"region":{"top_left_x":242,"top_left_y":326,"width":64,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1192bfd75974ec8988bec782db25e98","type":"text","conversion_output":true,"parent_id":"3328de4821c6489fb503744b0883aa6a","text":"12","text_display":"\n\n\\section*{12}","confidence":1,"confidence_rate":1},{"cnt":[[591,322],[849,322],[849,385],[591,385]],"region":{"top_left_x":590,"top_left_y":322,"width":259,"height":63},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5630b27001f64ffab5d985fc2ebd5e93","type":"section_header","conversion_output":false,"children_ids":["40bbb9d67b244028a5a1d87b5f4bd5b8"],"text":"","text_display":""},{"cnt":[[597,327],[844,327],[844,380],[597,380]],"region":{"top_left_x":597,"top_left_y":326,"width":248,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40bbb9d67b244028a5a1d87b5f4bd5b8","type":"text","conversion_output":true,"parent_id":"5630b27001f64ffab5d985fc2ebd5e93","text":"Appendices","text_display":"\n\n\\section*{Appendices}","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[241,417],[1886,417],[1886,541],[241,541]],"region":{"top_left_x":240,"top_left_y":416,"width":1647,"height":126},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96f14f52bb2e4a499386e93d55975d1b","type":"section_header","conversion_output":false,"children_ids":["c711bb96c8ca4a5185c771955a15bea6","67c3afbbf79d419192de8fe0f8c8b598"],"text":"","text_display":""},{"cnt":[[245,423],[1880,423],[1880,479],[245,479]],"region":{"top_left_x":244,"top_left_y":423,"width":1636,"height":57},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c711bb96c8ca4a5185c771955a15bea6","type":"text","conversion_output":true,"parent_id":"96f14f52bb2e4a499386e93d55975d1b","text":"Appendix A: American College of Rheumatology Criteria for the","text_display":"\n\n\\section*{Appendix A: American College of Rheumatology Criteria for the","confidence":1,"confidence_rate":1},{"cnt":[[589,477],[1798,477],[1798,535],[589,535]],"region":{"top_left_x":588,"top_left_y":476,"width":1211,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67c3afbbf79d419192de8fe0f8c8b598","type":"text","conversion_output":true,"parent_id":"96f14f52bb2e4a499386e93d55975d1b","text":"Classification and Reporting of Osteoarthritis of the Knee","text_display":" Classification and Reporting of Osteoarthritis of the Knee}","confidence":0.99951171875,"confidence_rate":0.9999922476411908},{"cnt":[[245,574],[1059,574],[1059,625],[245,625]],"region":{"top_left_x":244,"top_left_y":573,"width":816,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9658611f2be24590a504d7d40ddf02fd","type":"text","conversion_output":true,"text":"For this trial, please use the following reference:","text_display":"\n\nFor this trial, please use the following reference:","confidence":1,"confidence_rate":1},{"cnt":[[245,666],[1880,666],[1880,713],[245,713]],"region":{"top_left_x":244,"top_left_y":666,"width":1636,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cf1303c53584fd6bbab70a6bf656d94","type":"text","conversion_output":true,"text":"Altman R, Asch E, Bloch D, Bole G, Borenstein K, Brandt W, et al. Development of criteria for","text_display":"\nAltman R, Asch E, Bloch D, Bole G, Borenstein K, Brandt W, et al. Development of criteria for","confidence":1,"confidence_rate":1},{"cnt":[[245,713],[1878,713],[1878,763],[245,763]],"region":{"top_left_x":244,"top_left_y":713,"width":1634,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64ee1baafccf4c62a5fe1467c4862017","type":"text","conversion_output":true,"text":"the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee.","text_display":" the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee.","confidence":1,"confidence_rate":1},{"cnt":[[245,761],[1025,761],[1025,810],[245,810]],"region":{"top_left_x":244,"top_left_y":760,"width":781,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ea29327271644d490310391b56b03bf","type":"text","conversion_output":true,"text":"Arthritis \\& Rheumatism 1986;29(8): 1039-49.","text_display":" Arthritis \\& Rheumatism 1986;29(8): 1039-49.","confidence":0.99951171875,"confidence_rate":0.999989825041388},{"cnt":[[243,846],[1886,846],[1886,930],[243,930]],"region":{"top_left_x":242,"top_left_y":846,"width":1645,"height":85},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ceae287cadeb46419fb79b788a8f86da","type":"figure_label","conversion_output":false,"children_ids":["fe9f2f1b65cd42f99ee55176a7166d65","b097b29d622847568421d12a8e67c642","7f15eda7a36f49fa9e3a0842b8e1e941","b4265d42b91144739fc4c5904f1776d2"],"text":"","text_display":""},{"cnt":[[247,851],[389,851],[389,896],[247,896]],"region":{"top_left_x":247,"top_left_y":850,"width":142,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe9f2f1b65cd42f99ee55176a7166d65","type":"text","conversion_output":false,"parent_id":"ceae287cadeb46419fb79b788a8f86da","text":"Table 4","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[589,846],[1886,846],[1886,941],[589,941]],"region":{"top_left_x":588,"top_left_y":846,"width":1299,"height":96},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b097b29d622847568421d12a8e67c642","type":"text","conversion_output":false,"parent_id":"ceae287cadeb46419fb79b788a8f86da","text":"Summary of Criteria for Classification of Idiopathic Osteoarthritis of\nthe Knee","text_display":"","confidence":0.99658203125,"confidence_rate":0.9999650636373343},{"cnt":[[593,851],[1884,851],[1884,900],[593,900]],"region":{"top_left_x":592,"top_left_y":850,"width":1293,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f15eda7a36f49fa9e3a0842b8e1e941","type":"text","conversion_output":false,"parent_id":"ceae287cadeb46419fb79b788a8f86da","text":"Summary of Criteria for Classification of Idiopathic Osteoarthritis of","text_display":"","confidence":0.9912109375,"confidence_rate":0.9998823014053756},{"cnt":[[597,900],[761,900],[761,939],[597,939]],"region":{"top_left_x":597,"top_left_y":900,"width":164,"height":39},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4265d42b91144739fc4c5904f1776d2","type":"text","conversion_output":false,"parent_id":"ceae287cadeb46419fb79b788a8f86da","text":"the Knee","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[226,982],[1886,982],[1886,1659],[226,1659]],"region":{"top_left_x":225,"top_left_y":981,"width":1662,"height":678},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0a2db619aa14b7ca7355427f748de36","type":"table","conversion_output":true,"children_ids":["007cf728bb544a4abc6e9b68dace14b6","93588c67839c48e991fd83887b5a9b95","7c8d283886f04fa894662fe9b02b5be4","816038b709604d5f9b4cefa69609c2e8","9f3dc4ddd97346a380f27f2cdd85ee91","a05bc1f20cc7430a87c16d283e45346b","a943bbdf4c094171bb8d45441c6ea38f","fe0f148f974b410a9e9b187a3efa7754","413fbf4095d44df1ad6f4f56f9d44325","00e8caad6e5e499ba16484c1a92ce80b","7810f33293774265bf381ce98ceb4188","4e835a7612794a4c8982df7bf2579cf8","837e6d7b50e448e6b1642c105d1b9134","f585d04afd254e33a013b833c0c12a6c","ac9a7a5a24e94bc3b3430e67e9c60a37","a43e4af576c742189efb70e9e82a2f5d","0a21d0046dd74022b6eab94aa3efda1f","daeb2a232d2f4b22ae888c9bf0de4053","81775018b7eb43c8a9d17cf85dbc3ab7"],"selected_labels":["ceae287cadeb46419fb79b788a8f86da"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Clinical and Laboratory & Clinical and Radiographic & Clinical † \\\\\n\\hline \\begin{tabular}{l}\nKnee pain + at least 5 of 9: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Bony tenderness \\\\\n- Bony enlargement \\\\\n- No palpable warmth \\\\\n- ESR \\(<40 mm /\\) hour \\\\\n- \\(RF <1: 40\\) \\\\\n- SF OA\n\\end{tabular} & \\begin{tabular}{l}\nKnee pain + at least 1 of 3: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Osteophytes\n\\end{tabular} & \\begin{tabular}{l}\nKnee pain + at least 3 of 6: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Bony Tenderness \\\\\n- Bony enlargement \\\\\n- No palpable warmth\n\\end{tabular} \\\\\n\\hline 92\\% sensitive & 91\\% sensitive & 95\\% sensitive \\\\\n\\hline 75\\% specific & 86\\% specific & 69\\% specific \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 4 Summary of Criteria for Classification of Idiopathic Osteoarthritis of\nthe Knee Summary of Criteria for Classification of Idiopathic Osteoarthritis of the Knee}\n\\begin{tabular}{|l|l|l|}\n\\hline Clinical and Laboratory & Clinical and Radiographic & Clinical † \\\\\n\\hline \\begin{tabular}{l}\nKnee pain + at least 5 of 9: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Bony tenderness \\\\\n- Bony enlargement \\\\\n- No palpable warmth \\\\\n- ESR \\(<40 mm /\\) hour \\\\\n- \\(RF <1: 40\\) \\\\\n- SF OA\n\\end{tabular} & \\begin{tabular}{l}\nKnee pain + at least 1 of 3: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Osteophytes\n\\end{tabular} & \\begin{tabular}{l}\nKnee pain + at least 3 of 6: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Bony Tenderness \\\\\n- Bony enlargement \\\\\n- No palpable warmth\n\\end{tabular} \\\\\n\\hline 92\\% sensitive & 91\\% sensitive & 95\\% sensitive \\\\\n\\hline 75\\% specific & 86\\% specific & 69\\% specific \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.7576575572602451,"confidence_rate":0.9999184900015909},{"cnt":[[238,981],[686,981],[686,1659],[238,1659]],"region":{"top_left_x":237,"top_left_y":981,"width":450,"height":678},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"007cf728bb544a4abc6e9b68dace14b6","type":"table_column","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"","text_display":""},{"cnt":[[790,981],[1254,981],[1254,1659],[790,1659]],"region":{"top_left_x":790,"top_left_y":981,"width":464,"height":678},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93588c67839c48e991fd83887b5a9b95","type":"table_column","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"","text_display":""},{"cnt":[[1340,981],[1717,981],[1717,1659],[1340,1659]],"region":{"top_left_x":1340,"top_left_y":981,"width":378,"height":678},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c8d283886f04fa894662fe9b02b5be4","type":"table_column","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"","text_display":""},{"cnt":[[225,994],[1886,994],[1886,1044],[225,1044]],"region":{"top_left_x":225,"top_left_y":993,"width":1661,"height":51},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"816038b709604d5f9b4cefa69609c2e8","type":"table_row","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"","text_display":""},{"cnt":[[225,1055],[1886,1055],[1886,1546],[225,1546]],"region":{"top_left_x":225,"top_left_y":1054,"width":1661,"height":493},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f3dc4ddd97346a380f27f2cdd85ee91","type":"table_row","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"","text_display":""},{"cnt":[[225,1555],[1886,1555],[1886,1598],[225,1598]],"region":{"top_left_x":225,"top_left_y":1554,"width":1661,"height":45},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a05bc1f20cc7430a87c16d283e45346b","type":"table_row","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"","text_display":""},{"cnt":[[225,1650],[225,1605],[1886,1607],[1886,1652]],"region":{"top_left_x":224,"top_left_y":1604,"width":1662,"height":49},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a943bbdf4c094171bb8d45441c6ea38f","type":"table_row","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"","text_display":""},{"cnt":[[331,1000],[682,1000],[682,1039],[331,1039]],"region":{"top_left_x":331,"top_left_y":1000,"width":351,"height":40},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe0f148f974b410a9e9b187a3efa7754","type":"simple_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"Clinical and Laboratory","text_display":"Clinical and Laboratory","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[862,1000],[1249,1000],[1249,1039],[862,1039]],"region":{"top_left_x":861,"top_left_y":1000,"width":389,"height":40},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"413fbf4095d44df1ad6f4f56f9d44325","type":"simple_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"Clinical and Radiographic","text_display":"Clinical and Radiographic","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1537,1003],[1669,1003],[1669,1035],[1537,1035]],"region":{"top_left_x":1537,"top_left_y":1002,"width":133,"height":34},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00e8caad6e5e499ba16484c1a92ce80b","type":"simple_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"Clinical †","text_display":"Clinical †","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[244,1059],[615,1059],[615,1542],[244,1542]],"region":{"top_left_x":244,"top_left_y":1058,"width":371,"height":484},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7810f33293774265bf381ce98ceb4188","type":"complex_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","children_ids":["c39c62e350944c0e9b41ce227735a2eb","23f59a49d50d4ee0bf157f670474ab71","8ea3656c70164360b25853a6742fcd20","a5f23783178845ea9dac84dbc1bcec33","3e1cda5cbca0491ab719b1de5f906800","b6e904cd96594646874d103f493f8b33","19f59cdeb9954bff92487f1538c2e228","a18f1d130aff4fd3980be6d45a6e222d","01a46d97b1b84c349dc54f855fe2548b","f456241200314e178b41ec4537e9c44a","cf249fac3b9a40e7a126ec2754e2382d"],"text":"\\begin{tabular}{l}\nKnee pain + at least 5 of 9: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Bony tenderness \\\\\n- Bony enlargement \\\\\n- No palpable warmth \\\\\n- ESR \\(<40 mm /\\) hour \\\\\n- \\(RF <1: 40\\) \\\\\n- SF OA\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nKnee pain + at least 5 of 9: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Bony tenderness \\\\\n- Bony enlargement \\\\\n- No palpable warmth \\\\\n- ESR \\(<40 mm /\\) hour \\\\\n- \\(RF <1: 40\\) \\\\\n- SF OA\n\\end{tabular}","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.7576575572602451,"confidence_rate":0.9990811051323566},{"cnt":[[247,1061],[392,1061],[392,1096],[247,1096]],"region":{"top_left_x":246,"top_left_y":1061,"width":146,"height":35},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c39c62e350944c0e9b41ce227735a2eb","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"Knee pain","text_display":"Knee pain","confidence":1,"confidence_rate":1},{"cnt":[[247,1102],[474,1102],[474,1135],[247,1135]],"region":{"top_left_x":246,"top_left_y":1102,"width":229,"height":33},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23f59a49d50d4ee0bf157f670474ab71","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"+ at least 5 of 9:","text_display":" + at least 5 of 9:","confidence":0.99755859375,"confidence_rate":0.9999059893676697},{"cnt":[[247,1150],[513,1150],[513,1185],[247,1185]],"region":{"top_left_x":246,"top_left_y":1149,"width":268,"height":36},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ea3656c70164360b25853a6742fcd20","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"- Age > 50 years","text_display":"\n- Age > 50 years","confidence":1,"confidence_rate":1},{"cnt":[[247,1193],[608,1193],[608,1226],[247,1226]],"region":{"top_left_x":246,"top_left_y":1193,"width":363,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5f23783178845ea9dac84dbc1bcec33","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"- Stiffness < 30 minutes","text_display":"\n- Stiffness < 30 minutes","confidence":0.99755859375,"confidence_rate":0.9999236156879996},{"cnt":[[247,1237],[418,1237],[418,1273],[247,1273]],"region":{"top_left_x":246,"top_left_y":1236,"width":172,"height":38},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e1cda5cbca0491ab719b1de5f906800","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"- Crepitus","text_display":"\n- Crepitus","confidence":1,"confidence_rate":1},{"cnt":[[247,1284],[539,1284],[539,1321],[247,1321]],"region":{"top_left_x":246,"top_left_y":1284,"width":293,"height":37},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6e904cd96594646874d103f493f8b33","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"- Bony tenderness","text_display":"\n- Bony tenderness","confidence":1,"confidence_rate":1},{"cnt":[[247,1327],[556,1327],[556,1364],[247,1364]],"region":{"top_left_x":246,"top_left_y":1327,"width":311,"height":38},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19f59cdeb9954bff92487f1538c2e228","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"- Bony enlargement","text_display":"\n- Bony enlargement","confidence":1,"confidence_rate":1},{"cnt":[[247,1373],[578,1373],[578,1408],[247,1408]],"region":{"top_left_x":246,"top_left_y":1372,"width":332,"height":36},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a18f1d130aff4fd3980be6d45a6e222d","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"- No palpable warmth","text_display":"\n- No palpable warmth","confidence":1,"confidence_rate":1},{"cnt":[[247,1418],[569,1418],[569,1451],[247,1451]],"region":{"top_left_x":246,"top_left_y":1418,"width":324,"height":33},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01a46d97b1b84c349dc54f855fe2548b","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"- ESR \\(<40 mm /\\) hour","text_display":"\n- ESR \\(<40 mm /\\) hour","confidence":0.7576575572602451,"confidence_rate":0.9901373945575113},{"cnt":[[247,1462],[439,1462],[439,1494],[247,1494]],"region":{"top_left_x":246,"top_left_y":1461,"width":194,"height":34},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f456241200314e178b41ec4537e9c44a","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"- \\(RF <1: 40\\)","text_display":"\n- \\(RF <1: 40\\)","confidence":0.99951171875,"confidence_rate":0.9999694754347522},{"cnt":[[247,1509],[396,1509],[396,1538],[247,1538]],"region":{"top_left_x":246,"top_left_y":1509,"width":151,"height":29},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf249fac3b9a40e7a126ec2754e2382d","type":"text","conversion_output":false,"parent_id":"7810f33293774265bf381ce98ceb4188","text":"- SF OA","text_display":"\n- SF OA","confidence":1,"confidence_rate":1},{"cnt":[[792,1059],[1163,1059],[1163,1321],[792,1321]],"region":{"top_left_x":792,"top_left_y":1058,"width":371,"height":263},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e835a7612794a4c8982df7bf2579cf8","type":"complex_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","children_ids":["07202ce466c74ab29fd2c8584ddda342","f0776ff3ee504459b6c79b74d5b705c1","350edadf315844abb0811050d402b041","aa5cdf5ee86d4ce68032be5b103b2ab5","a3f8510e2d3c45b7af8b76899dc42170","00f5f0bcb09e493e980765261dcdc64c"],"text":"\\begin{tabular}{l}\nKnee pain + at least 1 of 3: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Osteophytes\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nKnee pain + at least 1 of 3: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Osteophytes\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999940645948945},{"cnt":[[797,1061],[942,1061],[942,1096],[797,1096]],"region":{"top_left_x":796,"top_left_y":1061,"width":146,"height":35},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07202ce466c74ab29fd2c8584ddda342","type":"text","conversion_output":false,"parent_id":"4e835a7612794a4c8982df7bf2579cf8","text":"Knee pain","text_display":"Knee pain","confidence":1,"confidence_rate":1},{"cnt":[[797,1102],[1024,1102],[1024,1135],[797,1135]],"region":{"top_left_x":796,"top_left_y":1102,"width":229,"height":33},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0776ff3ee504459b6c79b74d5b705c1","type":"text","conversion_output":false,"parent_id":"4e835a7612794a4c8982df7bf2579cf8","text":"+ at least 1 of 3:","text_display":" + at least 1 of 3:","confidence":1,"confidence_rate":1},{"cnt":[[797,1150],[1063,1150],[1063,1187],[797,1187]],"region":{"top_left_x":796,"top_left_y":1149,"width":268,"height":38},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"350edadf315844abb0811050d402b041","type":"text","conversion_output":false,"parent_id":"4e835a7612794a4c8982df7bf2579cf8","text":"- Age > 50 years","text_display":"\n- Age > 50 years","confidence":0.99951171875,"confidence_rate":0.9999796501863057},{"cnt":[[797,1193],[1163,1193],[1163,1226],[797,1226]],"region":{"top_left_x":796,"top_left_y":1193,"width":367,"height":33},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa5cdf5ee86d4ce68032be5b103b2ab5","type":"text","conversion_output":false,"parent_id":"4e835a7612794a4c8982df7bf2579cf8","text":"- Stiffness < 30 minutes","text_display":"\n- Stiffness < 30 minutes","confidence":0.99951171875,"confidence_rate":0.9999847376009057},{"cnt":[[797,1237],[968,1237],[968,1273],[797,1273]],"region":{"top_left_x":796,"top_left_y":1236,"width":172,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3f8510e2d3c45b7af8b76899dc42170","type":"text","conversion_output":false,"parent_id":"4e835a7612794a4c8982df7bf2579cf8","text":"- Crepitus","text_display":"\n- Crepitus","confidence":1,"confidence_rate":1},{"cnt":[[797,1284],[1028,1284],[1028,1321],[797,1321]],"region":{"top_left_x":796,"top_left_y":1284,"width":233,"height":37},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00f5f0bcb09e493e980765261dcdc64c","type":"text","conversion_output":false,"parent_id":"4e835a7612794a4c8982df7bf2579cf8","text":"- Osteophytes","text_display":"\n- Osteophytes","confidence":1,"confidence_rate":1},{"cnt":[[1342,1059],[1713,1059],[1713,1412],[1342,1412]],"region":{"top_left_x":1342,"top_left_y":1058,"width":371,"height":354},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"837e6d7b50e448e6b1642c105d1b9134","type":"complex_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","children_ids":["d0990727856e4c82952956c798ec2f62","2744eb626712413089ce9cead772eebd","364062290eae4140bc976dd3598045e7","5ddc45b99d254fa8bc89dbbddc9f4a12","982532ff3b5d450bb1e276a60b837274","38388a61af0b4401baf1ff320b057cb3","3708b8391feb46a5a03c30e58a2dbf7e","d1c6c00b0ada4965adc7aee54247def1"],"text":"\\begin{tabular}{l}\nKnee pain + at least 3 of 6: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Bony Tenderness \\\\\n- Bony enlargement \\\\\n- No palpable warmth\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nKnee pain + at least 3 of 6: \\\\\n- Age > 50 years \\\\\n- Stiffness < 30 minutes \\\\\n- Crepitus \\\\\n- Bony Tenderness \\\\\n- Bony enlargement \\\\\n- No palpable warmth\n\\end{tabular}","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.990234375,"confidence_rate":0.9999470942862616},{"cnt":[[1347,1061],[1492,1061],[1492,1096],[1347,1096]],"region":{"top_left_x":1346,"top_left_y":1061,"width":146,"height":35},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0990727856e4c82952956c798ec2f62","type":"text","conversion_output":false,"parent_id":"837e6d7b50e448e6b1642c105d1b9134","text":"Knee pain","text_display":"Knee pain","confidence":1,"confidence_rate":1},{"cnt":[[1347,1102],[1574,1102],[1574,1135],[1347,1135]],"region":{"top_left_x":1346,"top_left_y":1102,"width":229,"height":33},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2744eb626712413089ce9cead772eebd","type":"text","conversion_output":false,"parent_id":"837e6d7b50e448e6b1642c105d1b9134","text":"+ at least 3 of 6:","text_display":" + at least 3 of 6:","confidence":0.990234375,"confidence_rate":0.9996226242453677},{"cnt":[[1347,1150],[1613,1150],[1613,1185],[1347,1185]],"region":{"top_left_x":1346,"top_left_y":1149,"width":268,"height":36},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"364062290eae4140bc976dd3598045e7","type":"text","conversion_output":false,"parent_id":"837e6d7b50e448e6b1642c105d1b9134","text":"- Age > 50 years","text_display":"\n- Age > 50 years","confidence":1,"confidence_rate":1},{"cnt":[[1347,1193],[1708,1193],[1708,1226],[1347,1226]],"region":{"top_left_x":1346,"top_left_y":1193,"width":363,"height":33},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ddc45b99d254fa8bc89dbbddc9f4a12","type":"text","conversion_output":false,"parent_id":"837e6d7b50e448e6b1642c105d1b9134","text":"- Stiffness < 30 minutes","text_display":"\n- Stiffness < 30 minutes","confidence":0.99853515625,"confidence_rate":0.9999541911216807},{"cnt":[[1347,1237],[1518,1237],[1518,1273],[1347,1273]],"region":{"top_left_x":1346,"top_left_y":1236,"width":172,"height":38},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"982532ff3b5d450bb1e276a60b837274","type":"text","conversion_output":false,"parent_id":"837e6d7b50e448e6b1642c105d1b9134","text":"- Crepitus","text_display":"\n- Crepitus","confidence":1,"confidence_rate":1},{"cnt":[[1347,1284],[1648,1284],[1648,1321],[1347,1321]],"region":{"top_left_x":1346,"top_left_y":1284,"width":302,"height":37},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38388a61af0b4401baf1ff320b057cb3","type":"text","conversion_output":false,"parent_id":"837e6d7b50e448e6b1642c105d1b9134","text":"- Bony Tenderness","text_display":"\n- Bony Tenderness","confidence":1,"confidence_rate":1},{"cnt":[[1347,1327],[1656,1327],[1656,1364],[1347,1364]],"region":{"top_left_x":1346,"top_left_y":1327,"width":311,"height":38},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3708b8391feb46a5a03c30e58a2dbf7e","type":"text","conversion_output":false,"parent_id":"837e6d7b50e448e6b1642c105d1b9134","text":"- Bony enlargement","text_display":"\n- Bony enlargement","confidence":1,"confidence_rate":1},{"cnt":[[1347,1375],[1682,1375],[1682,1408],[1347,1408]],"region":{"top_left_x":1346,"top_left_y":1375,"width":337,"height":33},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1c6c00b0ada4965adc7aee54247def1","type":"text","conversion_output":false,"parent_id":"837e6d7b50e448e6b1642c105d1b9134","text":"- No palpable warmth","text_display":"\n- No palpable warmth","confidence":1,"confidence_rate":1},{"cnt":[[247,1561],[444,1561],[444,1590],[247,1590]],"region":{"top_left_x":246,"top_left_y":1561,"width":198,"height":29},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f585d04afd254e33a013b833c0c12a6c","type":"simple_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"92\\% sensitive","text_display":"92\\% sensitive","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[797,1561],[994,1561],[994,1590],[797,1590]],"region":{"top_left_x":796,"top_left_y":1561,"width":198,"height":29},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac9a7a5a24e94bc3b3430e67e9c60a37","type":"simple_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"91\\% sensitive","text_display":"91\\% sensitive","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1347,1561],[1544,1561],[1544,1590],[1347,1590]],"region":{"top_left_x":1346,"top_left_y":1561,"width":198,"height":29},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a43e4af576c742189efb70e9e82a2f5d","type":"simple_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"95\\% sensitive","text_display":"95\\% sensitive","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1613],[426,1613],[426,1646],[247,1646]],"region":{"top_left_x":246,"top_left_y":1613,"width":181,"height":33},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a21d0046dd74022b6eab94aa3efda1f","type":"simple_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"75\\% specific","text_display":"75\\% specific","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[799,1613],[976,1613],[976,1646],[799,1646]],"region":{"top_left_x":798,"top_left_y":1613,"width":179,"height":33},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"daeb2a232d2f4b22ae888c9bf0de4053","type":"simple_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"86\\% specific","text_display":"86\\% specific","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1347,1611],[1526,1611],[1526,1646],[1347,1646]],"region":{"top_left_x":1346,"top_left_y":1611,"width":181,"height":35},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81775018b7eb43c8a9d17cf85dbc3ab7","type":"simple_cell","conversion_output":false,"parent_id":"c0a2db619aa14b7ca7355427f748de36","text":"69\\% specific","text_display":"69\\% specific","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1663],[1803,1663],[1803,1699],[247,1699]],"region":{"top_left_x":247,"top_left_y":1662,"width":1556,"height":38},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06285a4ccd084460b8548469b606debb","type":"text","conversion_output":true,"text":"ESR = erythrocyte sedimentation rate (Westergren); RF = rheumatoid factor; SF OA = synovial fluid signs of OA","text_display":"\n\nESR = erythrocyte sedimentation rate (Westergren); RF = rheumatoid factor; SF OA = synovial fluid signs of OA","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[249,1693],[1010,1693],[1010,1738],[249,1738]],"region":{"top_left_x":249,"top_left_y":1692,"width":761,"height":47},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9d9f868d49142ecac9c527417fb710c","type":"text","conversion_output":true,"text":"(clear, viscous, or white blood cell count \\(<2,000 / mm ^{3}\\) ).","text_display":" (clear, viscous, or white blood cell count \\(<2,000 / mm ^{3}\\) ).","confidence":1,"confidence_rate":1},{"cnt":[[247,1740],[1558,1740],[1558,1781],[247,1781]],"region":{"top_left_x":247,"top_left_y":1740,"width":1311,"height":42},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7cd348e1e8f43b292310dd219d8bb55","type":"text","conversion_output":true,"text":"† Alternative for the clinical category would be 4 of 6 , which is \\(84 \\%\\) sensitive and \\(89 \\%\\) specific.","text_display":"\n† Alternative for the clinical category would be 4 of 6 , which is \\(84 \\%\\) sensitive and \\(89 \\%\\) specific.","confidence":0.8699032312051397,"confidence_rate":0.9987887923481238},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a14ee6b5c5fe42d1b59fe5ce018f4119","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1495,2522],[1601,2522],[1601,2563],[1495,2563]],"region":{"top_left_x":1495,"top_left_y":2522,"width":106,"height":42},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b735011117484478a2fc4dc4168a79ff","type":"page_info","conversion_output":false,"text":"104/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":37},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1ffee0c31e34329bfca363a0ec785dd","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-105","page":105,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7469412ee9f448c894d464786ba13c7","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[640,125],[1317,125],[1317,174],[640,174]],"region":{"top_left_x":640,"top_left_y":124,"width":677,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3858637d244f46ccb16630873bfcf75b","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[537,168],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":167,"width":294,"height":50},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd9b0a33574943ba898ea4d84eb0d2a2","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,314],[1240,314],[1240,389],[236,389]],"region":{"top_left_x":236,"top_left_y":313,"width":1004,"height":76},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc340c04ed194825b74f3978a21b3c3d","type":"section_header","conversion_output":false,"children_ids":["189999f244d84e399762b69e00a4666e"],"text":"","text_display":""},{"cnt":[[243,322],[1235,322],[1235,385],[243,385]],"region":{"top_left_x":242,"top_left_y":322,"width":994,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"189999f244d84e399762b69e00a4666e","type":"text","conversion_output":true,"parent_id":"bc340c04ed194825b74f3978a21b3c3d","text":"Appendix B: Safety Laboratory Parameters","text_display":"\n\n\\section*{Appendix B: Safety Laboratory Parameters}","confidence":1,"confidence_rate":1},{"cnt":[[243,397],[1171,397],[1171,449],[243,449]],"region":{"top_left_x":242,"top_left_y":397,"width":929,"height":53},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5199c9fab14f4716b0eec2bd9c94fb3b","type":"text","conversion_output":true,"text":"The following laboratory parameters will be measured.","text_display":"\n\nThe following laboratory parameters will be measured.","confidence":1,"confidence_rate":1},{"cnt":[[226,449],[1888,449],[1888,2451],[226,2451]],"region":{"top_left_x":225,"top_left_y":449,"width":1664,"height":2003},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03e280f45b1942e195dc72d102374097","type":"table","conversion_output":true,"children_ids":["4eb5d312f16b4308a512b2e945054dff","41de2168267d4adc9ce105e8f0cd5e69","7c6f72e021e9493893c849d9fd3fd1a2","7d8df436753b468890f662e3d13b4ac2","4e0e058392674d88ac8e4d10ff34ebb6","e1dedbed1bc44e5aa22285a43ce7e96a","025bb604c3394889ba14d92d9e10cec4","9c455d0cf5044b5d9494a306359cdcaa","73b65a001936403e8476701682200c86","dbe065d47fcd4d4aa8035ff3824bc85a","e3dd4b470016474eaf41de507930610d","0711e4be43604a339dfb09147da6fc93","5d4778215ce4469a833b9be23a2e0356","8c2574337560453caf58a35353c502be","f6d709ec6c6d425a86dbc56edcd6a9d7","f25728375354495ebfe9007d3f9eba88","e6d7c55e37de433f9139fc7d66fa54f9","0e83da9b52ea43e496082a3729db6824","0494983c67d745598b0933709afef3e5","584c5388c50e4633b13d4812618cfcf8"],"text":"\\begin{tabular}{|l|l|}\n\\hline Hematology & \\begin{tabular}{l}\n- White blood cell (WBC) count \\\\\n- Lymphocytes (absolute count, \\%) \\\\\n- Monocytes (absolute count, \\%) \\\\\n- Neutrophils (absolute count, \\%) \\\\\n- Eosinophils (absolute count, \\%) \\\\\n- Basophils (absolute count, \\%) \\\\\n- Red blood cells \\\\\n- Hematocrit \\\\\n- Hemoglobin \\\\\n- Platelets\n\\end{tabular} \\\\\n\\hline Coagulation (screening assessment only; to be done locally) & \\begin{tabular}{l}\n- Partial thromboplastin time (PTT) \\\\\n- International Normalized Ratio (INR)\n\\end{tabular} \\\\\n\\hline Clinical biochemistry & \\begin{tabular}{l}\n- Aspartate aminotransferase (AST) \\\\\n- Alanine aminotransferase (ALT) \\\\\n- Alkaline phosphatase (ALP) \\\\\n- Total protein \\\\\n- Total bilirubin \\\\\n- Creatine kinase (CK) \\\\\n- Creatinine \\\\\n- Calcium \\\\\n- Phosphorus \\\\\n- Sodium \\\\\n- Potassium \\\\\n- Magnesium \\\\\n- Blood urea nitrogen (BUN) \\\\\n- Glucose (not fasting) \\\\\n- Chloride \\\\\n- Albumin \\\\\n- High-sensitivity C-reactive protein (hsCRP) \\\\\n- Erythrocyte sedimentation rate (ESR) \\\\\n- Interleukin-6 (IL-6)\n\\end{tabular} \\\\\n\\hline Urinalysis & \\begin{tabular}{l}\n- Dipstick parameters: \\\\\n- pH \\\\\n- Specific gravity \\\\\n- Protein \\\\\n- Glucose \\\\\n- Ketones \\\\\n- Bilirubin \\\\\n- Blood \\\\\n- Urobilinogen \\\\\n- Leukocytes\n\\end{tabular} \\\\\n\\hline Pregnancy tests (to be done locally) & - Serum during screening; urine at other time points. \\\\\n\\hline Immunogenicity & - Presence of antibodies to sprifermin/FGF-18 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Hematology & \\begin{tabular}{l}\n- White blood cell (WBC) count \\\\\n- Lymphocytes (absolute count, \\%) \\\\\n- Monocytes (absolute count, \\%) \\\\\n- Neutrophils (absolute count, \\%) \\\\\n- Eosinophils (absolute count, \\%) \\\\\n- Basophils (absolute count, \\%) \\\\\n- Red blood cells \\\\\n- Hematocrit \\\\\n- Hemoglobin \\\\\n- Platelets\n\\end{tabular} \\\\\n\\hline Coagulation (screening assessment only; to be done locally) & \\begin{tabular}{l}\n- Partial thromboplastin time (PTT) \\\\\n- International Normalized Ratio (INR)\n\\end{tabular} \\\\\n\\hline Clinical biochemistry & \\begin{tabular}{l}\n- Aspartate aminotransferase (AST) \\\\\n- Alanine aminotransferase (ALT) \\\\\n- Alkaline phosphatase (ALP) \\\\\n- Total protein \\\\\n- Total bilirubin \\\\\n- Creatine kinase (CK) \\\\\n- Creatinine \\\\\n- Calcium \\\\\n- Phosphorus \\\\\n- Sodium \\\\\n- Potassium \\\\\n- Magnesium \\\\\n- Blood urea nitrogen (BUN) \\\\\n- Glucose (not fasting) \\\\\n- Chloride \\\\\n- Albumin \\\\\n- High-sensitivity C-reactive protein (hsCRP) \\\\\n- Erythrocyte sedimentation rate (ESR) \\\\\n- Interleukin-6 (IL-6)\n\\end{tabular} \\\\\n\\hline Urinalysis & \\begin{tabular}{l}\n- Dipstick parameters: \\\\\n- pH \\\\\n- Specific gravity \\\\\n- Protein \\\\\n- Glucose \\\\\n- Ketones \\\\\n- Bilirubin \\\\\n- Blood \\\\\n- Urobilinogen \\\\\n- Leukocytes\n\\end{tabular} \\\\\n\\hline Pregnancy tests (to be done locally) & - Serum during screening; urine at other time points. \\\\\n\\hline Immunogenicity & - Presence of antibodies to sprifermin/FGF-18 \\\\\n\\hline\n\\end{tabular}","confidence":0.95654296875,"confidence_rate":0.9999582006263367},{"cnt":[[236,449],[836,449],[836,2450],[236,2450]],"region":{"top_left_x":235,"top_left_y":449,"width":601,"height":2001},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4eb5d312f16b4308a512b2e945054dff","type":"table_column","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"","text_display":""},{"cnt":[[844,449],[1624,449],[1624,2450],[844,2450]],"region":{"top_left_x":844,"top_left_y":449,"width":780,"height":2001},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41de2168267d4adc9ce105e8f0cd5e69","type":"table_column","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"","text_display":""},{"cnt":[[225,455],[1888,455],[1888,912],[225,912]],"region":{"top_left_x":225,"top_left_y":455,"width":1664,"height":458},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c6f72e021e9493893c849d9fd3fd1a2","type":"table_row","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"","text_display":""},{"cnt":[[225,912],[1886,912],[1886,1016],[225,1016]],"region":{"top_left_x":225,"top_left_y":912,"width":1661,"height":105},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d8df436753b468890f662e3d13b4ac2","type":"table_row","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"","text_display":""},{"cnt":[[225,1012],[1886,1012],[1886,1880],[225,1880]],"region":{"top_left_x":225,"top_left_y":1012,"width":1661,"height":869},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e0e058392674d88ac8e4d10ff34ebb6","type":"table_row","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"","text_display":""},{"cnt":[[225,1878],[1886,1878],[1886,2335],[225,2335]],"region":{"top_left_x":225,"top_left_y":1878,"width":1661,"height":458},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1dedbed1bc44e5aa22285a43ce7e96a","type":"table_row","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"","text_display":""},{"cnt":[[225,2337],[1886,2337],[1886,2391],[225,2391]],"region":{"top_left_x":225,"top_left_y":2337,"width":1661,"height":55},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"025bb604c3394889ba14d92d9e10cec4","type":"table_row","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"","text_display":""},{"cnt":[[225,2391],[1886,2391],[1886,2446],[225,2446]],"region":{"top_left_x":225,"top_left_y":2391,"width":1661,"height":55},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c455d0cf5044b5d9494a306359cdcaa","type":"table_row","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"","text_display":""},{"cnt":[[247,466],[422,466],[422,503],[247,503]],"region":{"top_left_x":246,"top_left_y":466,"width":177,"height":38},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73b65a001936403e8476701682200c86","type":"simple_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"Hematology","text_display":"Hematology","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[853,462],[1381,462],[1381,910],[853,910]],"region":{"top_left_x":852,"top_left_y":461,"width":530,"height":450},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbe065d47fcd4d4aa8035ff3824bc85a","type":"complex_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","children_ids":["a0abec5cf1e24ad9bb3de9511008a8bc","508266f7414f482297d06315a9ad2415","675843e85d284bb7aa9c557c54649cd8","9a991ada9dff42ccb3ab1debdf5427b7","14f79529f29048d0a6dcb1cb1e9f4293","0f42d4c960bc438a801480b608bc6020","939d1f1a0cac430ba0dd7166826252e7","3d35e88decfc4d9fa5e97edfc5566ddb","56df550843f94733aa62095a89fe8521","96fa7ba12d324448804c3e25afdadda5"],"text":"\\begin{tabular}{l}\n- White blood cell (WBC) count \\\\\n- Lymphocytes (absolute count, \\%) \\\\\n- Monocytes (absolute count, \\%) \\\\\n- Neutrophils (absolute count, \\%) \\\\\n- Eosinophils (absolute count, \\%) \\\\\n- Basophils (absolute count, \\%) \\\\\n- Red blood cells \\\\\n- Hematocrit \\\\\n- Hemoglobin \\\\\n- Platelets\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n- White blood cell (WBC) count \\\\\n- Lymphocytes (absolute count, \\%) \\\\\n- Monocytes (absolute count, \\%) \\\\\n- Neutrophils (absolute count, \\%) \\\\\n- Eosinophils (absolute count, \\%) \\\\\n- Basophils (absolute count, \\%) \\\\\n- Red blood cells \\\\\n- Hematocrit \\\\\n- Hemoglobin \\\\\n- Platelets\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[857,466],[1327,466],[1327,505],[857,505]],"region":{"top_left_x":857,"top_left_y":466,"width":471,"height":40},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0abec5cf1e24ad9bb3de9511008a8bc","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- White blood cell (WBC) count","text_display":"- White blood cell (WBC) count","confidence":1,"confidence_rate":1},{"cnt":[[859,512],[1377,512],[1377,551],[859,551]],"region":{"top_left_x":859,"top_left_y":511,"width":519,"height":40},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"508266f7414f482297d06315a9ad2415","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- Lymphocytes (absolute count, \\%)","text_display":"\n- Lymphocytes (absolute count, \\%)","confidence":1,"confidence_rate":1},{"cnt":[[862,557],[1345,557],[1345,596],[862,596]],"region":{"top_left_x":861,"top_left_y":557,"width":484,"height":40},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"675843e85d284bb7aa9c557c54649cd8","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- Monocytes (absolute count, \\%)","text_display":"\n- Monocytes (absolute count, \\%)","confidence":1,"confidence_rate":1},{"cnt":[[859,601],[1353,601],[1353,642],[859,642]],"region":{"top_left_x":859,"top_left_y":600,"width":495,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a991ada9dff42ccb3ab1debdf5427b7","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- Neutrophils (absolute count, \\%)","text_display":"\n- Neutrophils (absolute count, \\%)","confidence":1,"confidence_rate":1},{"cnt":[[859,648],[1353,648],[1353,685],[859,685]],"region":{"top_left_x":859,"top_left_y":648,"width":495,"height":38},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14f79529f29048d0a6dcb1cb1e9f4293","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- Eosinophils (absolute count, \\%)","text_display":"\n- Eosinophils (absolute count, \\%)","confidence":1,"confidence_rate":1},{"cnt":[[859,692],[1329,692],[1329,733],[859,733]],"region":{"top_left_x":859,"top_left_y":691,"width":471,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f42d4c960bc438a801480b608bc6020","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- Basophils (absolute count, \\%)","text_display":"\n- Basophils (absolute count, \\%)","confidence":1,"confidence_rate":1},{"cnt":[[859,739],[1130,739],[1130,772],[859,772]],"region":{"top_left_x":859,"top_left_y":739,"width":272,"height":33},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"939d1f1a0cac430ba0dd7166826252e7","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- Red blood cells","text_display":"\n- Red blood cells","confidence":1,"confidence_rate":1},{"cnt":[[859,782],[1070,782],[1070,815],[859,815]],"region":{"top_left_x":859,"top_left_y":782,"width":211,"height":33},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d35e88decfc4d9fa5e97edfc5566ddb","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- Hematocrit","text_display":"\n- Hematocrit","confidence":1,"confidence_rate":1},{"cnt":[[857,826],[1083,826],[1083,867],[857,867]],"region":{"top_left_x":857,"top_left_y":825,"width":226,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56df550843f94733aa62095a89fe8521","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- Hemoglobin","text_display":"\n- Hemoglobin","confidence":1,"confidence_rate":1},{"cnt":[[857,873],[1037,873],[1037,906],[857,906]],"region":{"top_left_x":857,"top_left_y":873,"width":181,"height":33},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96fa7ba12d324448804c3e25afdadda5","type":"text","conversion_output":false,"parent_id":"dbe065d47fcd4d4aa8035ff3824bc85a","text":"- Platelets","text_display":"\n- Platelets","confidence":1,"confidence_rate":1},{"cnt":[[242,921],[825,921],[825,1001],[242,1001]],"region":{"top_left_x":242,"top_left_y":921,"width":583,"height":81},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3dd4b470016474eaf41de507930610d","type":"complex_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","children_ids":["2f395c6e2f29431bbeab14589926dbae","7e783bde33c04c5bb610014c253917ec"],"text":"Coagulation (screening assessment only; to be done locally)","text_display":"Coagulation (screening assessment only; to be done locally)","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,925],[825,925],[825,962],[247,962]],"region":{"top_left_x":246,"top_left_y":925,"width":579,"height":38},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f395c6e2f29431bbeab14589926dbae","type":"text","conversion_output":false,"parent_id":"e3dd4b470016474eaf41de507930610d","text":"Coagulation (screening assessment only;","text_display":"Coagulation (screening assessment only;","confidence":1,"confidence_rate":1},{"cnt":[[247,960],[509,960],[509,997],[247,997]],"region":{"top_left_x":246,"top_left_y":960,"width":263,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e783bde33c04c5bb610014c253917ec","type":"text","conversion_output":false,"parent_id":"e3dd4b470016474eaf41de507930610d","text":"to be done locally)","text_display":" to be done locally)","confidence":1,"confidence_rate":1},{"cnt":[[853,921],[1423,921],[1423,1014],[853,1014]],"region":{"top_left_x":852,"top_left_y":921,"width":571,"height":94},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0711e4be43604a339dfb09147da6fc93","type":"complex_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","children_ids":["00a556052fda4ec9b7e51e2836d9c6be","9973c2a08e794e63a4fe6943904f9767"],"text":"\\begin{tabular}{l}\n- Partial thromboplastin time (PTT) \\\\\n- International Normalized Ratio (INR)\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n- Partial thromboplastin time (PTT) \\\\\n- International Normalized Ratio (INR)\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[859,925],[1375,925],[1375,967],[859,967]],"region":{"top_left_x":859,"top_left_y":925,"width":516,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00a556052fda4ec9b7e51e2836d9c6be","type":"text","conversion_output":false,"parent_id":"0711e4be43604a339dfb09147da6fc93","text":"- Partial thromboplastin time (PTT)","text_display":"- Partial thromboplastin time (PTT)","confidence":0.99951171875,"confidence_rate":0.9999877900620892},{"cnt":[[859,971],[1418,971],[1418,1010],[859,1010]],"region":{"top_left_x":859,"top_left_y":970,"width":560,"height":40},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9973c2a08e794e63a4fe6943904f9767","type":"text","conversion_output":false,"parent_id":"0711e4be43604a339dfb09147da6fc93","text":"- International Normalized Ratio (INR)","text_display":"\n- International Normalized Ratio (INR)","confidence":1,"confidence_rate":1},{"cnt":[[247,1023],[539,1023],[539,1062],[247,1062]],"region":{"top_left_x":246,"top_left_y":1022,"width":293,"height":40},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d4778215ce4469a833b9be23a2e0356","type":"simple_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"Clinical biochemistry","text_display":"Clinical biochemistry","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[853,1021],[1518,1021],[1518,1878],[853,1878]],"region":{"top_left_x":852,"top_left_y":1020,"width":666,"height":859},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c2574337560453caf58a35353c502be","type":"complex_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","children_ids":["b28db2d11977425b96bdb748b1f48751","e4b34b1f65d04f00af81da150cc0cc13","17495631370640dd809080be29c4b01a","eb752f85afc845c481477705394707c5","8307c1366d2d4698836bf42d594b9125","9c2bfab087d24d3482537b4b093f9bc6","8ea46746b06d4cec977dbeeb5bb9f4a4","9e322b18c980456ca1bc4d4b70d6b5b3","b37c42cc524d4799ab5dd9df18cd35ee","ab55cc97d17b452fb6625d81a6c017d5","8eddd4c0d420453d9f3d11c879a5c8fa","a09df525c84f4807b8eeee50f253cfcf","4b712692645a4d469aac2277a33a86c0","9bd48f5652744ae3ba5f6d1497d62645","de4f4f1213ff49e3b17c89d00599160e","a9615c91ee524843873022a95d31e3a3","589540f5d8214feaa48e5d3d86b91b3d","a49f455057c74eae868f1ad8921f5fbf","b109c279a0c54e4a99f82fc81d6a1c31"],"text":"\\begin{tabular}{l}\n- Aspartate aminotransferase (AST) \\\\\n- Alanine aminotransferase (ALT) \\\\\n- Alkaline phosphatase (ALP) \\\\\n- Total protein \\\\\n- Total bilirubin \\\\\n- Creatine kinase (CK) \\\\\n- Creatinine \\\\\n- Calcium \\\\\n- Phosphorus \\\\\n- Sodium \\\\\n- Potassium \\\\\n- Magnesium \\\\\n- Blood urea nitrogen (BUN) \\\\\n- Glucose (not fasting) \\\\\n- Chloride \\\\\n- Albumin \\\\\n- High-sensitivity C-reactive protein (hsCRP) \\\\\n- Erythrocyte sedimentation rate (ESR) \\\\\n- Interleukin-6 (IL-6)\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n- Aspartate aminotransferase (AST) \\\\\n- Alanine aminotransferase (ALT) \\\\\n- Alkaline phosphatase (ALP) \\\\\n- Total protein \\\\\n- Total bilirubin \\\\\n- Creatine kinase (CK) \\\\\n- Creatinine \\\\\n- Calcium \\\\\n- Phosphorus \\\\\n- Sodium \\\\\n- Potassium \\\\\n- Magnesium \\\\\n- Blood urea nitrogen (BUN) \\\\\n- Glucose (not fasting) \\\\\n- Chloride \\\\\n- Albumin \\\\\n- High-sensitivity C-reactive protein (hsCRP) \\\\\n- Erythrocyte sedimentation rate (ESR) \\\\\n- Interleukin-6 (IL-6)\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999981639095875},{"cnt":[[859,1025],[1390,1025],[1390,1062],[859,1062]],"region":{"top_left_x":859,"top_left_y":1025,"width":532,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b28db2d11977425b96bdb748b1f48751","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Aspartate aminotransferase (AST)","text_display":"- Aspartate aminotransferase (AST)","confidence":1,"confidence_rate":1},{"cnt":[[857,1068],[1358,1068],[1358,1109],[857,1109]],"region":{"top_left_x":857,"top_left_y":1068,"width":501,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4b34b1f65d04f00af81da150cc0cc13","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Alanine aminotransferase (ALT)","text_display":"\n- Alanine aminotransferase (ALT)","confidence":1,"confidence_rate":1},{"cnt":[[859,1114],[1301,1114],[1301,1153],[859,1153]],"region":{"top_left_x":859,"top_left_y":1113,"width":443,"height":40},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17495631370640dd809080be29c4b01a","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Alkaline phosphatase (ALP)","text_display":"\n- Alkaline phosphatase (ALP)","confidence":1,"confidence_rate":1},{"cnt":[[859,1159],[1089,1159],[1089,1196],[859,1196]],"region":{"top_left_x":859,"top_left_y":1159,"width":231,"height":38},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb752f85afc845c481477705394707c5","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Total protein","text_display":"\n- Total protein","confidence":1,"confidence_rate":1},{"cnt":[[859,1205],[1102,1205],[1102,1239],[859,1239]],"region":{"top_left_x":859,"top_left_y":1204,"width":244,"height":36},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8307c1366d2d4698836bf42d594b9125","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Total bilirubin","text_display":"\n- Total bilirubin","confidence":1,"confidence_rate":1},{"cnt":[[859,1250],[1206,1250],[1206,1287],[859,1287]],"region":{"top_left_x":859,"top_left_y":1250,"width":347,"height":38},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c2bfab087d24d3482537b4b093f9bc6","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Creatine kinase (CK)","text_display":"\n- Creatine kinase (CK)","confidence":1,"confidence_rate":1},{"cnt":[[859,1294],[1059,1294],[1059,1330],[859,1330]],"region":{"top_left_x":859,"top_left_y":1293,"width":200,"height":38},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ea46746b06d4cec977dbeeb5bb9f4a4","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Creatinine","text_display":"\n- Creatinine","confidence":1,"confidence_rate":1},{"cnt":[[859,1341],[1028,1341],[1028,1374],[859,1374]],"region":{"top_left_x":859,"top_left_y":1341,"width":170,"height":33},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e322b18c980456ca1bc4d4b70d6b5b3","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Calcium","text_display":"\n- Calcium","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[857,1384],[1080,1384],[1080,1421],[857,1421]],"region":{"top_left_x":857,"top_left_y":1384,"width":224,"height":38},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b37c42cc524d4799ab5dd9df18cd35ee","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Phosphorus","text_display":"\n- Phosphorus","confidence":1,"confidence_rate":1},{"cnt":[[859,1432],[1024,1432],[1024,1465],[859,1465]],"region":{"top_left_x":859,"top_left_y":1432,"width":166,"height":33},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab55cc97d17b452fb6625d81a6c017d5","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Sodium","text_display":"\n- Sodium","confidence":1,"confidence_rate":1},{"cnt":[[859,1475],[1063,1475],[1063,1508],[859,1508]],"region":{"top_left_x":859,"top_left_y":1475,"width":205,"height":33},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8eddd4c0d420453d9f3d11c879a5c8fa","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Potassium","text_display":"\n- Potassium","confidence":1,"confidence_rate":1},{"cnt":[[859,1519],[1076,1519],[1076,1560],[859,1560]],"region":{"top_left_x":859,"top_left_y":1518,"width":218,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a09df525c84f4807b8eeee50f253cfcf","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Magnesium","text_display":"\n- Magnesium","confidence":1,"confidence_rate":1},{"cnt":[[859,1564],[1284,1564],[1284,1603],[859,1603]],"region":{"top_left_x":859,"top_left_y":1564,"width":425,"height":40},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b712692645a4d469aac2277a33a86c0","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Blood urea nitrogen (BUN)","text_display":"\n- Blood urea nitrogen (BUN)","confidence":1,"confidence_rate":1},{"cnt":[[859,1610],[1202,1610],[1202,1649],[859,1649]],"region":{"top_left_x":859,"top_left_y":1609,"width":343,"height":40},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bd48f5652744ae3ba5f6d1497d62645","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Glucose (not fasting)","text_display":"\n- Glucose (not fasting)","confidence":1,"confidence_rate":1},{"cnt":[[859,1655],[1033,1655],[1033,1690],[859,1690]],"region":{"top_left_x":859,"top_left_y":1655,"width":174,"height":35},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de4f4f1213ff49e3b17c89d00599160e","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Chloride","text_display":"\n- Chloride","confidence":1,"confidence_rate":1},{"cnt":[[859,1701],[1028,1701],[1028,1733],[859,1733]],"region":{"top_left_x":859,"top_left_y":1700,"width":170,"height":34},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9615c91ee524843873022a95d31e3a3","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Albumin","text_display":"\n- Albumin","confidence":1,"confidence_rate":1},{"cnt":[[859,1744],[1509,1744],[1509,1785],[859,1785]],"region":{"top_left_x":859,"top_left_y":1743,"width":651,"height":43},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"589540f5d8214feaa48e5d3d86b91b3d","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- High-sensitivity C-reactive protein (hsCRP)","text_display":"\n- High-sensitivity C-reactive protein (hsCRP)","confidence":1,"confidence_rate":1},{"cnt":[[859,1789],[1433,1789],[1433,1828],[859,1828]],"region":{"top_left_x":859,"top_left_y":1789,"width":575,"height":40},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a49f455057c74eae868f1ad8921f5fbf","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Erythrocyte sedimentation rate (ESR)","text_display":"\n- Erythrocyte sedimentation rate (ESR)","confidence":1,"confidence_rate":1},{"cnt":[[857,1835],[1171,1835],[1171,1872],[857,1872]],"region":{"top_left_x":857,"top_left_y":1834,"width":315,"height":38},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b109c279a0c54e4a99f82fc81d6a1c31","type":"text","conversion_output":false,"parent_id":"8c2574337560453caf58a35353c502be","text":"- Interleukin-6 (IL-6)","text_display":"\n- Interleukin-6 (IL-6)","confidence":1,"confidence_rate":1},{"cnt":[[247,1887],[387,1887],[387,1926],[247,1926]],"region":{"top_left_x":246,"top_left_y":1886,"width":142,"height":40},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6d709ec6c6d425a86dbc56edcd6a9d7","type":"simple_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"Urinalysis","text_display":"Urinalysis","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[853,1883],[1206,1883],[1206,2335],[853,2335]],"region":{"top_left_x":852,"top_left_y":1882,"width":354,"height":454},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f25728375354495ebfe9007d3f9eba88","type":"complex_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","children_ids":["cab596a22f2c4f489e34a0a675b1ba2c","4fc636800ade41f68a7acc392631c34d","4be1f048a5464bc8ab8aa0970d567114","2e77e94bdc3b450fad7a1a19e29533d4","1bcb852d2d104d0c9760bee51318a300","24155be97f96420696fbf0d329a1e5a7","e53ad4bc1f6e4520b3a75ce374d32f70","4aa700020de949048356bbf9d701fee4","5b58d83145d3439aae8d9a0f94be6c91","868a9f0bf0d84da1a8e239c6ca050e6d"],"text":"\\begin{tabular}{l}\n- Dipstick parameters: \\\\\n- pH \\\\\n- Specific gravity \\\\\n- Protein \\\\\n- Glucose \\\\\n- Ketones \\\\\n- Bilirubin \\\\\n- Blood \\\\\n- Urobilinogen \\\\\n- Leukocytes\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n- Dipstick parameters: \\\\\n- pH \\\\\n- Specific gravity \\\\\n- Protein \\\\\n- Glucose \\\\\n- Ketones \\\\\n- Bilirubin \\\\\n- Blood \\\\\n- Urobilinogen \\\\\n- Leukocytes\n\\end{tabular}","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.95654296875,"confidence_rate":0.9995064599619179},{"cnt":[[857,1889],[1202,1889],[1202,1928],[857,1928]],"region":{"top_left_x":857,"top_left_y":1889,"width":345,"height":40},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cab596a22f2c4f489e34a0a675b1ba2c","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- Dipstick parameters:","text_display":"- Dipstick parameters:","confidence":1,"confidence_rate":1},{"cnt":[[857,1935],[955,1935],[955,1971],[857,1971]],"region":{"top_left_x":857,"top_left_y":1934,"width":98,"height":38},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fc636800ade41f68a7acc392631c34d","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- pH","text_display":"\n- pH","confidence":0.95654296875,"confidence_rate":0.9950755463851624},{"cnt":[[859,1978],[1128,1978],[1128,2019],[859,2019]],"region":{"top_left_x":859,"top_left_y":1977,"width":270,"height":42},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4be1f048a5464bc8ab8aa0970d567114","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- Specific gravity","text_display":"\n- Specific gravity","confidence":1,"confidence_rate":1},{"cnt":[[857,2021],[1015,2021],[1015,2058],[857,2058]],"region":{"top_left_x":857,"top_left_y":2021,"width":159,"height":37},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e77e94bdc3b450fad7a1a19e29533d4","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- Protein","text_display":"\n- Protein","confidence":1,"confidence_rate":1},{"cnt":[[857,2069],[1031,2069],[1031,2101],[857,2101]],"region":{"top_left_x":857,"top_left_y":2068,"width":174,"height":34},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bcb852d2d104d0c9760bee51318a300","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- Glucose","text_display":"\n- Glucose","confidence":1,"confidence_rate":1},{"cnt":[[857,2112],[1031,2112],[1031,2149],[857,2149]],"region":{"top_left_x":857,"top_left_y":2112,"width":174,"height":37},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24155be97f96420696fbf0d329a1e5a7","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- Ketones","text_display":"\n- Ketones","confidence":1,"confidence_rate":1},{"cnt":[[857,2160],[1028,2160],[1028,2192],[857,2192]],"region":{"top_left_x":857,"top_left_y":2159,"width":172,"height":34},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e53ad4bc1f6e4520b3a75ce374d32f70","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- Bilirubin","text_display":"\n- Bilirubin","confidence":1,"confidence_rate":1},{"cnt":[[857,2203],[996,2203],[996,2236],[857,2236]],"region":{"top_left_x":857,"top_left_y":2203,"width":139,"height":33},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4aa700020de949048356bbf9d701fee4","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- Blood","text_display":"\n- Blood","confidence":1,"confidence_rate":1},{"cnt":[[857,2246],[1093,2246],[1093,2288],[857,2288]],"region":{"top_left_x":857,"top_left_y":2246,"width":237,"height":42},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b58d83145d3439aae8d9a0f94be6c91","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- Urobilinogen","text_display":"\n- Urobilinogen","confidence":1,"confidence_rate":1},{"cnt":[[857,2294],[1076,2294],[1076,2331],[857,2331]],"region":{"top_left_x":857,"top_left_y":2293,"width":220,"height":38},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"868a9f0bf0d84da1a8e239c6ca050e6d","type":"text","conversion_output":false,"parent_id":"f25728375354495ebfe9007d3f9eba88","text":"- Leukocytes","text_display":"\n- Leukocytes","confidence":1,"confidence_rate":1},{"cnt":[[247,2346],[751,2346],[751,2383],[247,2383]],"region":{"top_left_x":246,"top_left_y":2345,"width":506,"height":38},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6d7c55e37de433f9139fc7d66fa54f9","type":"simple_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"Pregnancy tests (to be done locally)","text_display":"Pregnancy tests (to be done locally)","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[859,2346],[1617,2346],[1617,2387],[859,2387]],"region":{"top_left_x":859,"top_left_y":2345,"width":759,"height":43},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e83da9b52ea43e496082a3729db6824","type":"simple_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"- Serum during screening; urine at other time points.","text_display":"- Serum during screening; urine at other time points.","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2398],[474,2398],[474,2439],[247,2439]],"region":{"top_left_x":246,"top_left_y":2397,"width":229,"height":43},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0494983c67d745598b0933709afef3e5","type":"simple_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"Immunogenicity","text_display":"Immunogenicity","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[859,2402],[1531,2402],[1531,2439],[859,2439]],"region":{"top_left_x":859,"top_left_y":2402,"width":672,"height":38},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"584c5388c50e4633b13d4812618cfcf8","type":"simple_cell","conversion_output":false,"parent_id":"03e280f45b1942e195dc72d102374097","text":"- Presence of antibodies to sprifermin/FGF-18","text_display":"- Presence of antibodies to sprifermin/FGF-18","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,2443],[1394,2443],[1394,2486],[245,2486]],"region":{"top_left_x":244,"top_left_y":2442,"width":1151,"height":44},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"298a3c709be84ea6b04c18a1f5f39e4e","type":"text","conversion_output":true,"text":"Instructions for sample collection, handling, and shipping are provided in the MOP.","text_display":"\n\nInstructions for sample collection, handling, and shipping are provided in the MOP.","confidence":1,"confidence_rate":1},{"cnt":[[245,2505],[440,2505],[440,2542],[245,2542]],"region":{"top_left_x":244,"top_left_y":2505,"width":197,"height":37},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac2f3fb7e721421d99846568ed2e3633","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[391,2544],[391,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":148,"height":46},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da70663dbf8645df9544c82c8bfa0e95","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1491,2527],[1603,2527],[1603,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2526,"width":112,"height":38},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c964f22b14d647768c2febd0dc6c3ab5","type":"page_info","conversion_output":false,"text":"105/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-106","page":106,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d7b683e158b4ff58268c5adafb5e8d1","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27b88bc546794fc1a4d15e0137753fd4","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[539,172],[539,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":296,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df6420227f8e4a299a9f96faa1143130","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,314],[1863,314],[1863,391],[236,391]],"region":{"top_left_x":236,"top_left_y":313,"width":1627,"height":79},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1198e417b2d041c396ef426b29d996ec","type":"section_header","conversion_output":false,"children_ids":["a32364df6c664425901733d3fc479639"],"text":"","text_display":""},{"cnt":[[243,320],[1854,320],[1854,382],[243,382]],"region":{"top_left_x":242,"top_left_y":320,"width":1613,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a32364df6c664425901733d3fc479639","type":"text","conversion_output":true,"parent_id":"1198e417b2d041c396ef426b29d996ec","text":"Appendix C: Subject Questionnaires: WOMAC, MOS SF-36, and ICOAP","text_display":"\n\n\\section*{Appendix C: Subject Questionnaires: WOMAC, MOS SF-36, and ICOAP}","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1422,417],[1422,471],[245,471]],"region":{"top_left_x":244,"top_left_y":416,"width":1179,"height":55},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aecabb6876684d219ee8135b04df1645","type":"text","conversion_output":true,"text":"Subjects will complete all of the following questionnaires themselves.","text_display":"\n\nSubjects will complete all of the following questionnaires themselves.","confidence":0.99951171875,"confidence_rate":0.9999934880145616},{"cnt":[[236,501],[1886,501],[1886,617],[236,617]],"region":{"top_left_x":236,"top_left_y":500,"width":1651,"height":117},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7135b75f25004768aa33bcb4c2831069","type":"section_header","conversion_output":false,"children_ids":["803fd594e3e14e12ae3cc305fd0a7563","eb957a35809e4f13ab8a0823cf53bde2"],"text":"","text_display":""},{"cnt":[[243,507],[1884,507],[1884,561],[243,561]],"region":{"top_left_x":242,"top_left_y":507,"width":1643,"height":54},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"803fd594e3e14e12ae3cc305fd0a7563","type":"text","conversion_output":true,"parent_id":"7135b75f25004768aa33bcb4c2831069","text":"Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)","text_display":"\n\n\\section*{Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[509,559],[509,608],[245,608]],"region":{"top_left_x":244,"top_left_y":558,"width":266,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb957a35809e4f13ab8a0823cf53bde2","type":"text","conversion_output":true,"parent_id":"7135b75f25004768aa33bcb4c2831069","text":"Questionnaire","text_display":" Questionnaire}","confidence":1,"confidence_rate":1},{"cnt":[[243,649],[1882,649],[1882,700],[243,700]],"region":{"top_left_x":242,"top_left_y":648,"width":1641,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9146fb55552148529f069372bd17ddfd","type":"text","conversion_output":true,"text":"Appropriate translations of the entire WOMAC \\({ }^{\\text {TM }}\\) version 3.1 questionnaire (11-box numerical","text_display":"\n\nAppropriate translations of the entire WOMAC \\({ }^{\\text {TM }}\\) version 3.1 questionnaire (11-box numerical","confidence":0.6327219009399414,"confidence_rate":0.9959929245017445},{"cnt":[[245,692],[621,692],[621,752],[245,752]],"region":{"top_left_x":244,"top_left_y":691,"width":377,"height":61},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"443fc06ad08045bd982e1f09c920d329","type":"text","conversion_output":true,"text":"scale version) by PPD","text_display":" scale version) by PPD","confidence":1,"confidence_rate":1},{"cnt":[[846,696],[1742,696],[1742,750],[846,750]],"region":{"top_left_x":846,"top_left_y":696,"width":897,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6499f7714a574e4ebaa460b0732dac33","type":"text","conversion_output":true,"text":"and the corresponding User's Guide 3.1 will be used.","text_display":" and the corresponding User's Guide 3.1 will be used.","confidence":0.99951171875,"confidence_rate":0.999991860024828},{"cnt":[[245,784],[1882,784],[1882,838],[245,838]],"region":{"top_left_x":244,"top_left_y":784,"width":1639,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1646b90bda048c3a3502b55151d2821","type":"text","conversion_output":true,"text":"For administration of the questionnaire, instructions for the WOMAC 3.1 Index should be","text_display":"\n\nFor administration of the questionnaire, instructions for the WOMAC 3.1 Index should be","confidence":0.64404296875,"confidence_rate":0.9952289197455422},{"cnt":[[245,834],[415,834],[415,883],[245,883]],"region":{"top_left_x":244,"top_left_y":833,"width":171,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"328767bb99a943afaca889020d3227c9","type":"text","conversion_output":true,"text":"followed.","text_display":" followed.","confidence":1,"confidence_rate":1},{"cnt":[[243,924],[1738,924],[1738,982],[243,982]],"region":{"top_left_x":242,"top_left_y":923,"width":1497,"height":59},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2d072da80dc4a2fb813566c56a5f3a7","type":"text","conversion_output":true,"text":"The WOMAC \\({ }^{\\text {™ }}\\) version 3.1 questionnaire and User's Guide will be provided separately.","text_display":"\n\nThe WOMAC \\({ }^{\\text {™ }}\\) version 3.1 questionnaire and User's Guide will be provided separately.","confidence":0.6968812663797053,"confidence_rate":0.9966616935377267},{"cnt":[[236,1100],[1652,1100],[1652,1167],[236,1167]],"region":{"top_left_x":236,"top_left_y":1100,"width":1417,"height":67},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32a5feb0748b4cef9dd254c80a9f0cb8","type":"section_header","conversion_output":false,"children_ids":["a02473c6083d4030af6ad65cf6432024"],"text":"","text_display":""},{"cnt":[[245,1109],[1646,1109],[1646,1158],[245,1158]],"region":{"top_left_x":244,"top_left_y":1108,"width":1402,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a02473c6083d4030af6ad65cf6432024","type":"text","conversion_output":true,"parent_id":"32a5feb0748b4cef9dd254c80a9f0cb8","text":"Medical Outcomes Study Short Form-36 General Health Survey (MOS SF-36)","text_display":"\n\n\\section*{Medical Outcomes Study Short Form-36 General Health Survey (MOS SF-36)}","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1882,1195],[1882,1248],[245,1248]],"region":{"top_left_x":244,"top_left_y":1194,"width":1639,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"426e86dfd8ab4efb9bafa0520eab6b42","type":"text","conversion_output":true,"text":"Appropriate translations of the MOS SF-36 version 2.0 and the corresponding User's Manual","text_display":"\n\nAppropriate translations of the MOS SF-36 version 2.0 and the corresponding User's Manual","confidence":1,"confidence_rate":1},{"cnt":[[245,1246],[466,1246],[466,1291],[245,1291]],"region":{"top_left_x":244,"top_left_y":1246,"width":223,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70c3f90ef34a4f0c842435135960779c","type":"text","conversion_output":true,"text":"will be used.","text_display":" will be used.","confidence":1,"confidence_rate":1},{"cnt":[[243,1332],[1764,1332],[1764,1386],[243,1386]],"region":{"top_left_x":242,"top_left_y":1332,"width":1522,"height":54},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22fdbdb03da940f2af54834a231ee232","type":"text","conversion_output":true,"text":"The MOS SF-36 questionnaire version 2.0 and User's Manual will be provided separately.","text_display":"\n\nThe MOS SF-36 questionnaire version 2.0 and User's Manual will be provided separately.","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[236,1506],[1729,1506],[1729,1573],[236,1573]],"region":{"top_left_x":236,"top_left_y":1506,"width":1494,"height":67},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfadbfb15bdc45b5b630482a6bc2ff7f","type":"section_header","conversion_output":false,"children_ids":["d7f7d1d7c1a54a1fa098e9221992d139"],"text":"","text_display":""},{"cnt":[[245,1512],[1723,1512],[1723,1566],[245,1566]],"region":{"top_left_x":244,"top_left_y":1512,"width":1480,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7f7d1d7c1a54a1fa098e9221992d139","type":"text","conversion_output":true,"parent_id":"bfadbfb15bdc45b5b630482a6bc2ff7f","text":"Measure of Intermittent and Constant Osteoarthritis Pain Questionnaire (ICOAP)","text_display":"\n\n\\section*{Measure of Intermittent and Constant Osteoarthritis Pain Questionnaire (ICOAP)}","confidence":1,"confidence_rate":1},{"cnt":[[243,1603],[1882,1603],[1882,1656],[243,1656]],"region":{"top_left_x":242,"top_left_y":1602,"width":1641,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9437bae105a4d9a8bd59806b54cbf94","type":"text","conversion_output":true,"text":"Version 3 of the ICOAP questionnaire and the corresponding User's Guide will be used in this","text_display":"\n\nVersion 3 of the ICOAP questionnaire and the corresponding User's Guide will be used in this","confidence":1,"confidence_rate":1},{"cnt":[[245,1650],[333,1650],[333,1697],[245,1697]],"region":{"top_left_x":244,"top_left_y":1650,"width":90,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a33118e0ccba4803812defd1a4e3606b","type":"text","conversion_output":true,"text":"trial.","text_display":" trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,1740],[1884,1740],[1884,1792],[245,1792]],"region":{"top_left_x":244,"top_left_y":1740,"width":1641,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce21d10cdc294f6aa93e827d64887779","type":"text","conversion_output":true,"text":"The ICOAP will only be used in countries for which an appropriate validated translation of the","text_display":"\n\nThe ICOAP will only be used in countries for which an appropriate validated translation of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[690,1788],[690,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1787,"width":446,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"472a97c5e3c24cae8861e2ce29b77241","type":"text","conversion_output":true,"text":"questionnaire is available.","text_display":" questionnaire is available.","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1884,1878],[1884,1929],[245,1929]],"region":{"top_left_x":244,"top_left_y":1877,"width":1641,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9d25106d4be49b68812465377c6d158","type":"text","conversion_output":true,"text":"For administration of the questionnaire, instructions in the User's Guide for the ICOAP, version","text_display":"\n\nFor administration of the questionnaire, instructions in the User's Guide for the ICOAP, version","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1687,1925],[1687,1979],[245,1979]],"region":{"top_left_x":244,"top_left_y":1925,"width":1443,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c47b27eb7a6c4c0282a7c404b23eaf5e","type":"text","conversion_output":true,"text":"3, should be followed. In this trial, the questionnaire will be completed by the subject.","text_display":" 3, should be followed. In this trial, the questionnaire will be completed by the subject.","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,2013],[1639,2013],[1639,2069],[245,2069]],"region":{"top_left_x":244,"top_left_y":2013,"width":1396,"height":56},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b01f0cf31af841f4bdb85c0d14fcac2f","type":"text","conversion_output":true,"text":"The questionnaire and the corresponding User's Guide will be provided separately.","text_display":"\n\nThe questionnaire and the corresponding User's Guide will be provided separately.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"65ad8cfe74f84a67b182629c832115c5","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[391,2544],[391,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2543,"width":148,"height":46},"line":31,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a6b701ea3f8e4fba9db0b3fc90b9e237","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1491,2527],[1605,2527],[1605,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2526,"width":114,"height":38},"line":32,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"83e611e34b6141429737c7e08876b878","type":"page_info","conversion_output":false,"text":"106/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-107","page":107,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"279714f516ef4e87b9abc078be2b92c6","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23f884843dc74793aea10c919769f667","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cea26c89b7e4eed8e1d8135aabff759","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,275],[1893,275],[1893,406],[236,406]],"region":{"top_left_x":236,"top_left_y":275,"width":1657,"height":132},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1ae73376f254ab1a2ecbde93c505dff","type":"section_header","conversion_output":false,"children_ids":["73becbafa1c040018baf5c3675663b53","42d4b489fd094b59a8179db2a465728a"],"text":"","text_display":""},{"cnt":[[243,279],[1886,279],[1886,342],[243,342]],"region":{"top_left_x":242,"top_left_y":279,"width":1645,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73becbafa1c040018baf5c3675663b53","type":"text","conversion_output":true,"parent_id":"f1ae73376f254ab1a2ecbde93c505dff","text":"Appendix D: Knee Injury and Osteoarthritis Outcome Score Quality of","text_display":"\n\n\\section*{Appendix D: Knee Injury and Osteoarthritis Outcome Score Quality of","confidence":1,"confidence_rate":1},{"cnt":[[587,339],[1635,339],[1635,397],[587,397]],"region":{"top_left_x":586,"top_left_y":339,"width":1049,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42d4b489fd094b59a8179db2a465728a","type":"text","conversion_output":true,"parent_id":"f1ae73376f254ab1a2ecbde93c505dff","text":"Life (KOOS QOL) and Symptom Index Subscales","text_display":" Life (KOOS QOL) and Symptom Index Subscales}","confidence":1,"confidence_rate":1},{"cnt":[[245,434],[1882,434],[1882,486],[245,486]],"region":{"top_left_x":244,"top_left_y":433,"width":1639,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0619e81c2f544f5390388839a02696d4","type":"text","conversion_output":true,"text":"The KOOS QOL consists of the following 4 questions, to be evaluated by the subject using the","text_display":"\n\nThe KOOS QOL consists of the following 4 questions, to be evaluated by the subject using the","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,481],[660,481],[660,535],[245,535]],"region":{"top_left_x":244,"top_left_y":481,"width":416,"height":54},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5d30e771c384a76b1ae7ad51d0ac966","type":"text","conversion_output":true,"text":"indicated 5-point scales.","text_display":" indicated 5-point scales.","confidence":1,"confidence_rate":1},{"cnt":[[245,571],[1137,571],[1137,623],[245,623]],"region":{"top_left_x":244,"top_left_y":571,"width":893,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"393ba1f8403f459b9cf9cd97d2b8db94","type":"text","conversion_output":true,"text":"Q1. How often are you aware of your knee problem?","text_display":"\n\nQ1. How often are you aware of your knee problem?","confidence":1,"confidence_rate":1},{"cnt":[[281,705],[1880,705],[1880,814],[281,814]],"region":{"top_left_x":281,"top_left_y":704,"width":1599,"height":111},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5755bbb5981d4dcb9ef694e8eb37a2ca","type":"multiple_choice_block","conversion_output":false,"children_ids":["a852af24e6e54bc38f087a4735bd4a07","101abd2006264f29acb61a80192a67e4","a958ac0b0257475eb89c3389bcb30fa5","540b093761564f2e8ad71617c235d5a4","9ee82c8a67124e55b7c85f500e41b53c"],"text":"","text_display":""},{"cnt":[[288,713],[385,713],[385,806],[288,806]],"region":{"top_left_x":287,"top_left_y":713,"width":98,"height":93},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a852af24e6e54bc38f087a4735bd4a07","type":"multiple_choice_option","conversion_output":false,"parent_id":"5755bbb5981d4dcb9ef694e8eb37a2ca","children_ids":["6fab9c4705ba403781e5e05ce85d4eac","ddc3a7e0a9d14f4d870b1cfdd8bdfa49"],"text":"","text_display":""},{"cnt":[[288,715],[385,715],[385,750],[288,750]],"region":{"top_left_x":287,"top_left_y":715,"width":98,"height":35},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fab9c4705ba403781e5e05ce85d4eac","type":"text","conversion_output":true,"parent_id":"a852af24e6e54bc38f087a4735bd4a07","text":"Never","text_display":"\nNever","confidence":1,"confidence_rate":1},{"cnt":[[314,761],[357,761],[357,804],[314,804]],"region":{"top_left_x":313,"top_left_y":760,"width":44,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ddc3a7e0a9d14f4d870b1cfdd8bdfa49","type":"form_field","conversion_output":true,"parent_id":"a852af24e6e54bc38f087a4735bd4a07","text":"","text_display":"\n□","subtype":"box"},{"cnt":[[625,709],[754,709],[754,806],[625,806]],"region":{"top_left_x":625,"top_left_y":708,"width":130,"height":98},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"101abd2006264f29acb61a80192a67e4","type":"multiple_choice_option","conversion_output":false,"parent_id":"5755bbb5981d4dcb9ef694e8eb37a2ca","children_ids":["37bd99ece7564ca7acd82f3c3780f610","e5f15d9babca4651ba587e2bd8710c29"],"text":"","text_display":""},{"cnt":[[632,713],[748,713],[748,754],[632,754]],"region":{"top_left_x":631,"top_left_y":713,"width":117,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37bd99ece7564ca7acd82f3c3780f610","type":"text","conversion_output":true,"parent_id":"101abd2006264f29acb61a80192a67e4","text":"Monthly","text_display":"\nMonthly","confidence":1,"confidence_rate":1},{"cnt":[[666,761],[711,761],[711,804],[666,804]],"region":{"top_left_x":666,"top_left_y":760,"width":46,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5f15d9babca4651ba587e2bd8710c29","type":"form_field","conversion_output":true,"parent_id":"101abd2006264f29acb61a80192a67e4","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[997,713],[1115,713],[1115,806],[997,806]],"region":{"top_left_x":996,"top_left_y":713,"width":120,"height":93},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a958ac0b0257475eb89c3389bcb30fa5","type":"multiple_choice_option","conversion_output":false,"parent_id":"5755bbb5981d4dcb9ef694e8eb37a2ca","children_ids":["1d79628ed96f48c1a96f02c19c6882b0","beb234aed4024ffb9d1d857a197e9b7c"],"text":"","text_display":""},{"cnt":[[1001,715],[1111,715],[1111,754],[1001,754]],"region":{"top_left_x":1001,"top_left_y":715,"width":110,"height":40},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d79628ed96f48c1a96f02c19c6882b0","type":"text","conversion_output":true,"parent_id":"a958ac0b0257475eb89c3389bcb30fa5","text":"Weekly","text_display":"\nWeekly","confidence":1,"confidence_rate":1},{"cnt":[[1036,761],[1079,761],[1079,804],[1036,804]],"region":{"top_left_x":1035,"top_left_y":760,"width":44,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"beb234aed4024ffb9d1d857a197e9b7c","type":"form_field","conversion_output":true,"parent_id":"a958ac0b0257475eb89c3389bcb30fa5","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1379,711],[1463,711],[1463,806],[1379,806]],"region":{"top_left_x":1379,"top_left_y":711,"width":85,"height":95},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"540b093761564f2e8ad71617c235d5a4","type":"multiple_choice_option","conversion_output":false,"parent_id":"5755bbb5981d4dcb9ef694e8eb37a2ca","children_ids":["b37fca3c03d64959a8d2619895f638f3","91cd2783f9a844a6b612bd26f9bf0685"],"text":"","text_display":""},{"cnt":[[1384,715],[1463,715],[1463,754],[1384,754]],"region":{"top_left_x":1383,"top_left_y":715,"width":81,"height":40},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b37fca3c03d64959a8d2619895f638f3","type":"text","conversion_output":true,"parent_id":"540b093761564f2e8ad71617c235d5a4","text":"Daily","text_display":"\nDaily","confidence":1,"confidence_rate":1},{"cnt":[[1401,761],[1448,761],[1448,804],[1401,804]],"region":{"top_left_x":1400,"top_left_y":760,"width":49,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91cd2783f9a844a6b612bd26f9bf0685","type":"form_field","conversion_output":true,"parent_id":"540b093761564f2e8ad71617c235d5a4","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1706,709],[1871,709],[1871,806],[1706,806]],"region":{"top_left_x":1705,"top_left_y":708,"width":167,"height":98},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ee82c8a67124e55b7c85f500e41b53c","type":"multiple_choice_option","conversion_output":false,"parent_id":"5755bbb5981d4dcb9ef694e8eb37a2ca","children_ids":["b4943efc9e9a4d5baed63ab5fe148994","4e3056900e2c47629a2a47764dd7ae2d"],"text":"","text_display":""},{"cnt":[[1710,713],[1867,713],[1867,754],[1710,754]],"region":{"top_left_x":1710,"top_left_y":713,"width":157,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4943efc9e9a4d5baed63ab5fe148994","type":"text","conversion_output":true,"parent_id":"9ee82c8a67124e55b7c85f500e41b53c","text":"Constantly","text_display":"\nConstantly","confidence":1,"confidence_rate":1},{"cnt":[[1770,761],[1818,761],[1818,804],[1770,804]],"region":{"top_left_x":1770,"top_left_y":760,"width":48,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e3056900e2c47629a2a47764dd7ae2d","type":"form_field","conversion_output":true,"parent_id":"9ee82c8a67124e55b7c85f500e41b53c","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[245,941],[1796,941],[1796,990],[245,990]],"region":{"top_left_x":244,"top_left_y":941,"width":1553,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0248480b8bc2422194b941a15f48bc2a","type":"text","conversion_output":true,"text":"Q2. Have you modified your life style to avoid potentially damaging activities to your knee?","text_display":"\n\nQ2. Have you modified your life style to avoid potentially damaging activities to your knee?","confidence":1,"confidence_rate":1},{"cnt":[[262,1076],[1843,1076],[1843,1175],[262,1175]],"region":{"top_left_x":262,"top_left_y":1076,"width":1582,"height":100},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2623eacc39f44c88b4ea157207359362","type":"multiple_choice_block","conversion_output":false,"children_ids":["e7ae8bad06144617a57c261ea3225a23","75aae692bbce42699533cc57a682d43b","3d02caab659a46ff81bfde740a9c6523","479ca4d3845646efb60b8842ef9e57cb","adb5b913ab47405e86facec8da33dade"],"text":"","text_display":""},{"cnt":[[266,1083],[397,1083],[397,1171],[266,1171]],"region":{"top_left_x":266,"top_left_y":1082,"width":132,"height":89},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7ae8bad06144617a57c261ea3225a23","type":"multiple_choice_option","conversion_output":false,"parent_id":"2623eacc39f44c88b4ea157207359362","children_ids":["6ec49105feb04835a9db6c0ac5231596","22cd4bf9397f47acbd4bb28eff52271e"],"text":"","text_display":""},{"cnt":[[266,1085],[397,1085],[397,1119],[266,1119]],"region":{"top_left_x":266,"top_left_y":1084,"width":132,"height":36},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ec49105feb04835a9db6c0ac5231596","type":"text","conversion_output":true,"parent_id":"e7ae8bad06144617a57c261ea3225a23","text":"Not at all","text_display":"\nNot at all","confidence":1,"confidence_rate":1},{"cnt":[[312,1124],[352,1124],[352,1175],[312,1175]],"region":{"top_left_x":311,"top_left_y":1123,"width":42,"height":53},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22cd4bf9397f47acbd4bb28eff52271e","type":"form_field","conversion_output":true,"parent_id":"e7ae8bad06144617a57c261ea3225a23","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[640,1083],[735,1083],[735,1171],[640,1171]],"region":{"top_left_x":640,"top_left_y":1082,"width":95,"height":89},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75aae692bbce42699533cc57a682d43b","type":"multiple_choice_option","conversion_output":false,"parent_id":"2623eacc39f44c88b4ea157207359362","children_ids":["2dcf95cf8a704600bd9cfee69e85145d","6fc4ef82674145cabf73eb6aa914a66b"],"text":"","text_display":""},{"cnt":[[645,1087],[733,1087],[733,1124],[645,1124]],"region":{"top_left_x":644,"top_left_y":1087,"width":89,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2dcf95cf8a704600bd9cfee69e85145d","type":"text","conversion_output":true,"parent_id":"75aae692bbce42699533cc57a682d43b","text":"Mildly","text_display":"\nMildly","confidence":1,"confidence_rate":1},{"cnt":[[666,1130],[709,1130],[709,1173],[666,1173]],"region":{"top_left_x":666,"top_left_y":1130,"width":43,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fc4ef82674145cabf73eb6aa914a66b","type":"form_field","conversion_output":true,"parent_id":"75aae692bbce42699533cc57a682d43b","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[975,1083],[1141,1083],[1141,1171],[975,1171]],"region":{"top_left_x":975,"top_left_y":1082,"width":166,"height":89},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d02caab659a46ff81bfde740a9c6523","type":"multiple_choice_option","conversion_output":false,"parent_id":"2623eacc39f44c88b4ea157207359362","children_ids":["e11a4d673e414671a394379f0e4e430e","b58df594c3db4029b9006319e8a9882f"],"text":"","text_display":""},{"cnt":[[975,1085],[1141,1085],[1141,1124],[975,1124]],"region":{"top_left_x":975,"top_left_y":1084,"width":166,"height":40},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e11a4d673e414671a394379f0e4e430e","type":"text","conversion_output":true,"parent_id":"3d02caab659a46ff81bfde740a9c6523","text":"Moderately","text_display":"\nModerately","confidence":1,"confidence_rate":1},{"cnt":[[1038,1124],[1079,1124],[1079,1175],[1038,1175]],"region":{"top_left_x":1037,"top_left_y":1123,"width":42,"height":53},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b58df594c3db4029b9006319e8a9882f","type":"form_field","conversion_output":true,"parent_id":"3d02caab659a46ff81bfde740a9c6523","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1362,1083],[1497,1083],[1497,1171],[1362,1171]],"region":{"top_left_x":1362,"top_left_y":1082,"width":136,"height":89},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"479ca4d3845646efb60b8842ef9e57cb","type":"multiple_choice_option","conversion_output":false,"parent_id":"2623eacc39f44c88b4ea157207359362","children_ids":["6fb633679c2f4f78bbde32b1577bee11","2c5284244124445892ba71ce3f3ae0fe"],"text":"","text_display":""},{"cnt":[[1362,1085],[1493,1085],[1493,1124],[1362,1124]],"region":{"top_left_x":1362,"top_left_y":1084,"width":132,"height":40},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fb633679c2f4f78bbde32b1577bee11","type":"text","conversion_output":true,"parent_id":"479ca4d3845646efb60b8842ef9e57cb","text":"Severely","text_display":"\nSeverely","confidence":1,"confidence_rate":1},{"cnt":[[1409,1124],[1452,1124],[1452,1175],[1409,1175]],"region":{"top_left_x":1409,"top_left_y":1123,"width":44,"height":53},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c5284244124445892ba71ce3f3ae0fe","type":"form_field","conversion_output":true,"parent_id":"479ca4d3845646efb60b8842ef9e57cb","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1732,1083],[1841,1083],[1841,1171],[1732,1171]],"region":{"top_left_x":1731,"top_left_y":1082,"width":111,"height":89},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"adb5b913ab47405e86facec8da33dade","type":"multiple_choice_option","conversion_output":false,"parent_id":"2623eacc39f44c88b4ea157207359362","children_ids":["e685bf5c0fb444d5b715096ab4b90b6d","7e968fc15e1b4b498e84eddcb189964d"],"text":"","text_display":""},{"cnt":[[1738,1085],[1837,1085],[1837,1124],[1738,1124]],"region":{"top_left_x":1738,"top_left_y":1084,"width":99,"height":40},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e685bf5c0fb444d5b715096ab4b90b6d","type":"text","conversion_output":true,"parent_id":"adb5b913ab47405e86facec8da33dade","text":"Totally","text_display":"\nTotally","confidence":1,"confidence_rate":1},{"cnt":[[1766,1130],[1813,1130],[1813,1173],[1766,1173]],"region":{"top_left_x":1766,"top_left_y":1130,"width":48,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e968fc15e1b4b498e84eddcb189964d","type":"form_field","conversion_output":true,"parent_id":"adb5b913ab47405e86facec8da33dade","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[245,1308],[1433,1308],[1433,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1308,"width":1190,"height":52},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3baed0be897411d86cdf511bb306a29","type":"text","conversion_output":true,"text":"Q3. How much are you troubled with lack of confidence in your knee?","text_display":"\n\nQ3. How much are you troubled with lack of confidence in your knee?","confidence":1,"confidence_rate":1},{"cnt":[[271,1446],[1867,1446],[1867,1543],[271,1543]],"region":{"top_left_x":270,"top_left_y":1445,"width":1597,"height":98},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd8bd9c1cbad41eeb1f889bf8f867a2a","type":"multiple_choice_block","conversion_output":false,"children_ids":["02ed4ab7c95048d0850cf3df72c2856a","6d6ea4ff63784606a1b7df1b02455e5b","6fa4c8f82cb34faf8d79e4bcf4eceff5","572f8ed06dff4f1fb1d8642f6920f160","228b4308c6834968b9f49463fd7277fb"],"text":"","text_display":""},{"cnt":[[277,1450],[410,1450],[410,1540],[277,1540]],"region":{"top_left_x":277,"top_left_y":1450,"width":134,"height":91},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02ed4ab7c95048d0850cf3df72c2856a","type":"multiple_choice_option","conversion_output":false,"parent_id":"cd8bd9c1cbad41eeb1f889bf8f867a2a","children_ids":["e97da7753c4a4883a48d5f3c03bb92ca","1ab2bc7714af4e079442fc0254071603"],"text":"","text_display":""},{"cnt":[[279,1452],[406,1452],[406,1485],[279,1485]],"region":{"top_left_x":279,"top_left_y":1452,"width":128,"height":33},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e97da7753c4a4883a48d5f3c03bb92ca","type":"text","conversion_output":true,"parent_id":"02ed4ab7c95048d0850cf3df72c2856a","text":"Not at all","text_display":"\nNot at all","confidence":1,"confidence_rate":1},{"cnt":[[312,1500],[365,1500],[365,1538],[312,1538]],"region":{"top_left_x":311,"top_left_y":1499,"width":55,"height":40},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ab2bc7714af4e079442fc0254071603","type":"form_field","conversion_output":true,"parent_id":"02ed4ab7c95048d0850cf3df72c2856a","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[657,1450],[750,1450],[750,1540],[657,1540]],"region":{"top_left_x":657,"top_left_y":1450,"width":93,"height":91},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d6ea4ff63784606a1b7df1b02455e5b","type":"multiple_choice_option","conversion_output":false,"parent_id":"cd8bd9c1cbad41eeb1f889bf8f867a2a","children_ids":["a67032f1979e41a09beb65ed92830800","65dfc2d39701459b9d26cde6f3dd77a4"],"text":"","text_display":""},{"cnt":[[660,1452],[746,1452],[746,1489],[660,1489]],"region":{"top_left_x":659,"top_left_y":1452,"width":87,"height":37},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a67032f1979e41a09beb65ed92830800","type":"text","conversion_output":true,"parent_id":"6d6ea4ff63784606a1b7df1b02455e5b","text":"Mildly","text_display":"\nMildly","confidence":1,"confidence_rate":1},{"cnt":[[675,1500],[722,1500],[722,1538],[675,1538]],"region":{"top_left_x":674,"top_left_y":1499,"width":48,"height":40},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65dfc2d39701459b9d26cde6f3dd77a4","type":"form_field","conversion_output":true,"parent_id":"6d6ea4ff63784606a1b7df1b02455e5b","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[975,1450],[1141,1450],[1141,1540],[975,1540]],"region":{"top_left_x":975,"top_left_y":1450,"width":166,"height":91},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fa4c8f82cb34faf8d79e4bcf4eceff5","type":"multiple_choice_option","conversion_output":false,"parent_id":"cd8bd9c1cbad41eeb1f889bf8f867a2a","children_ids":["1b9d27cf54324d4c9eda2aa80eaad0a3","4df46cf3b2df457088d1c2332a17eceb"],"text":"","text_display":""},{"cnt":[[975,1452],[1139,1452],[1139,1489],[975,1489]],"region":{"top_left_x":975,"top_left_y":1452,"width":164,"height":37},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b9d27cf54324d4c9eda2aa80eaad0a3","type":"text","conversion_output":true,"parent_id":"6fa4c8f82cb34faf8d79e4bcf4eceff5","text":"Moderately","text_display":"\nModerately","confidence":1,"confidence_rate":1},{"cnt":[[1038,1500],[1079,1500],[1079,1538],[1038,1538]],"region":{"top_left_x":1037,"top_left_y":1499,"width":42,"height":40},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4df46cf3b2df457088d1c2332a17eceb","type":"form_field","conversion_output":true,"parent_id":"6fa4c8f82cb34faf8d79e4bcf4eceff5","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1360,1450],[1493,1450],[1493,1540],[1360,1540]],"region":{"top_left_x":1359,"top_left_y":1450,"width":135,"height":91},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"572f8ed06dff4f1fb1d8642f6920f160","type":"multiple_choice_option","conversion_output":false,"parent_id":"cd8bd9c1cbad41eeb1f889bf8f867a2a","children_ids":["2b8e9bc92b05427ba473f8088438af48","7db3669933e54e248fcada2be568972d"],"text":"","text_display":""},{"cnt":[[1362,1452],[1489,1452],[1489,1489],[1362,1489]],"region":{"top_left_x":1362,"top_left_y":1452,"width":127,"height":37},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b8e9bc92b05427ba473f8088438af48","type":"text","conversion_output":true,"parent_id":"572f8ed06dff4f1fb1d8642f6920f160","text":"Severely","text_display":"\nSeverely","confidence":1,"confidence_rate":1},{"cnt":[[1403,1500],[1452,1500],[1452,1538],[1403,1538]],"region":{"top_left_x":1402,"top_left_y":1499,"width":51,"height":40},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7db3669933e54e248fcada2be568972d","type":"form_field","conversion_output":true,"parent_id":"572f8ed06dff4f1fb1d8642f6920f160","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1710,1450],[1863,1450],[1863,1540],[1710,1540]],"region":{"top_left_x":1710,"top_left_y":1450,"width":153,"height":91},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"228b4308c6834968b9f49463fd7277fb","type":"multiple_choice_option","conversion_output":false,"parent_id":"cd8bd9c1cbad41eeb1f889bf8f867a2a","children_ids":["400a906d79dc4118ba060a2d21e6cc69","8943ee1779664e97b02ef68a7aa9e4a0"],"text":"","text_display":""},{"cnt":[[1714,1452],[1858,1452],[1858,1489],[1714,1489]],"region":{"top_left_x":1714,"top_left_y":1452,"width":145,"height":37},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"400a906d79dc4118ba060a2d21e6cc69","type":"text","conversion_output":true,"parent_id":"228b4308c6834968b9f49463fd7277fb","text":"Extremely","text_display":"\nExtremely","confidence":1,"confidence_rate":1},{"cnt":[[1766,1500],[1805,1500],[1805,1538],[1766,1538]],"region":{"top_left_x":1766,"top_left_y":1499,"width":39,"height":40},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8943ee1779664e97b02ef68a7aa9e4a0","type":"form_field","conversion_output":true,"parent_id":"228b4308c6834968b9f49463fd7277fb","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[245,1676],[1347,1676],[1347,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1675,"width":1104,"height":51},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e7f800cc65e426aabd7a8339a1b7bcc","type":"text","conversion_output":true,"text":"Q4. In general, how much difficulty do you have with your knee?","text_display":"\n\nQ4. In general, how much difficulty do you have with your knee?","confidence":1,"confidence_rate":1},{"cnt":[[288,1813],[1852,1813],[1852,1912],[288,1912]],"region":{"top_left_x":287,"top_left_y":1813,"width":1565,"height":100},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ad99f3362cd4607922cf3b3691994ba","type":"multiple_choice_block","conversion_output":false,"children_ids":["2f7c13c4d9d74bc08ba9d424e72eef16","2e95fd162ebe421091f5186e72bcc270","3b37ef194cd5488196dd4a4159b87d07","0cc900e483094fdabffec351a765ca46","09424f05b950474eb5a5409ef3ee0a6d"],"text":"","text_display":""},{"cnt":[[288,1818],[376,1818],[376,1910],[288,1910]],"region":{"top_left_x":287,"top_left_y":1817,"width":89,"height":93},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f7c13c4d9d74bc08ba9d424e72eef16","type":"multiple_choice_option","conversion_output":false,"parent_id":"3ad99f3362cd4607922cf3b3691994ba","children_ids":["16efb237f548444fbd10fcf9fbd39ba7","c942b3e07dfe49539c61bbf111e47403"],"text":"","text_display":""},{"cnt":[[292,1822],[374,1822],[374,1856],[292,1856]],"region":{"top_left_x":292,"top_left_y":1821,"width":82,"height":36},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16efb237f548444fbd10fcf9fbd39ba7","type":"text","conversion_output":true,"parent_id":"2f7c13c4d9d74bc08ba9d424e72eef16","text":"None","text_display":"\nNone","confidence":1,"confidence_rate":1},{"cnt":[[312,1867],[354,1867],[354,1908],[312,1908]],"region":{"top_left_x":311,"top_left_y":1866,"width":44,"height":42},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c942b3e07dfe49539c61bbf111e47403","type":"form_field","conversion_output":true,"parent_id":"2f7c13c4d9d74bc08ba9d424e72eef16","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[653,1822],[720,1822],[720,1910],[653,1910]],"region":{"top_left_x":653,"top_left_y":1821,"width":67,"height":89},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e95fd162ebe421091f5186e72bcc270","type":"multiple_choice_option","conversion_output":false,"parent_id":"3ad99f3362cd4607922cf3b3691994ba","children_ids":["11b48c8265ec4b03ab4f93c3e1850872","aa5fa69768734f7a9c82838a53e9ac64"],"text":"","text_display":""},{"cnt":[[657,1822],[722,1822],[722,1856],[657,1856]],"region":{"top_left_x":657,"top_left_y":1821,"width":65,"height":36},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11b48c8265ec4b03ab4f93c3e1850872","type":"text","conversion_output":true,"parent_id":"2e95fd162ebe421091f5186e72bcc270","text":"Mild","text_display":"\nMild","confidence":1,"confidence_rate":1},{"cnt":[[666,1869],[709,1869],[709,1912],[666,1912]],"region":{"top_left_x":666,"top_left_y":1869,"width":43,"height":44},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa5fa69768734f7a9c82838a53e9ac64","type":"form_field","conversion_output":true,"parent_id":"2e95fd162ebe421091f5186e72bcc270","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[980,1818],[1124,1818],[1124,1910],[980,1910]],"region":{"top_left_x":979,"top_left_y":1817,"width":145,"height":93},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b37ef194cd5488196dd4a4159b87d07","type":"multiple_choice_option","conversion_output":false,"parent_id":"3ad99f3362cd4607922cf3b3691994ba","children_ids":["802f68ba10d845c88f4f3899829b3b41","dc170098e6de41fe9d353511ea66650c"],"text":"","text_display":""},{"cnt":[[984,1822],[1121,1822],[1121,1854],[984,1854]],"region":{"top_left_x":983,"top_left_y":1821,"width":139,"height":34},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"802f68ba10d845c88f4f3899829b3b41","type":"text","conversion_output":true,"parent_id":"3b37ef194cd5488196dd4a4159b87d07","text":"Moderate","text_display":"\nModerate","confidence":1,"confidence_rate":1},{"cnt":[[1036,1867],[1074,1867],[1074,1908],[1036,1908]],"region":{"top_left_x":1035,"top_left_y":1866,"width":40,"height":42},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc170098e6de41fe9d353511ea66650c","type":"form_field","conversion_output":true,"parent_id":"3b37ef194cd5488196dd4a4159b87d07","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1364,1822],[1476,1822],[1476,1910],[1364,1910]],"region":{"top_left_x":1364,"top_left_y":1821,"width":112,"height":89},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cc900e483094fdabffec351a765ca46","type":"multiple_choice_option","conversion_output":false,"parent_id":"3ad99f3362cd4607922cf3b3691994ba","children_ids":["9f1a37a3f5b34b078877cad7812d7068","489d36aa2da24facad73e8d3d22c5db6"],"text":"","text_display":""},{"cnt":[[1366,1822],[1472,1822],[1472,1854],[1366,1854]],"region":{"top_left_x":1366,"top_left_y":1821,"width":106,"height":34},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f1a37a3f5b34b078877cad7812d7068","type":"text","conversion_output":true,"parent_id":"0cc900e483094fdabffec351a765ca46","text":"Severe","text_display":"\nSevere","confidence":1,"confidence_rate":1},{"cnt":[[1401,1867],[1439,1867],[1439,1908],[1401,1908]],"region":{"top_left_x":1400,"top_left_y":1866,"width":40,"height":42},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"489d36aa2da24facad73e8d3d22c5db6","type":"form_field","conversion_output":true,"parent_id":"0cc900e483094fdabffec351a765ca46","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1723,1822],[1846,1822],[1846,1906],[1723,1906]],"region":{"top_left_x":1723,"top_left_y":1821,"width":123,"height":85},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09424f05b950474eb5a5409ef3ee0a6d","type":"multiple_choice_option","conversion_output":false,"parent_id":"3ad99f3362cd4607922cf3b3691994ba","children_ids":["136e7efe4ff9412aa82073ba6154359a","f41a88e82c4c4dc9aa1b7f16a621d228"],"text":"","text_display":""},{"cnt":[[1723,1822],[1846,1822],[1846,1854],[1723,1854]],"region":{"top_left_x":1723,"top_left_y":1821,"width":123,"height":34},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"136e7efe4ff9412aa82073ba6154359a","type":"text","conversion_output":true,"parent_id":"09424f05b950474eb5a5409ef3ee0a6d","text":"Extreme","text_display":"\nExtreme","confidence":1,"confidence_rate":1},{"cnt":[[1766,1867],[1805,1867],[1805,1908],[1766,1908]],"region":{"top_left_x":1766,"top_left_y":1866,"width":39,"height":42},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f41a88e82c4c4dc9aa1b7f16a621d228","type":"form_field","conversion_output":true,"parent_id":"09424f05b950474eb5a5409ef3ee0a6d","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[245,2514],[436,2514],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2513,"width":193,"height":33},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6a7d734db984810a026d94026191935","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a31b251d8b794068b774d8768fccc9f2","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[443,2514],[507,2514],[507,2544],[443,2544]],"region":{"top_left_x":442,"top_left_y":2513,"width":66,"height":31},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6805844cb051465289fc7eb382e4bb75","type":"page_info","conversion_output":false,"text":"CCI","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1495,2531],[1601,2531],[1601,2563],[1495,2563]],"region":{"top_left_x":1495,"top_left_y":2530,"width":106,"height":34},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65066b64a16e48849978f1c575a51931","type":"page_info","conversion_output":false,"text":"107/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1899,2501],[1899,2597],[1796,2597]],"region":{"top_left_x":1796,"top_left_y":2500,"width":104,"height":98},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2a9745515324b48ad4c7c52d83e77f3","type":"page_info","conversion_output":false,"text":"","text_display":""}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-108","page":108,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f75be6842b24de89a4b3363e547e81e","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57b8006a27c9408daa90126dcbb45247","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73dce048e85e42c08f59f0dcbb3faf20","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,320],[1884,320],[1884,374],[245,374]],"region":{"top_left_x":244,"top_left_y":320,"width":1641,"height":54},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2e3ccf89a9e41999115754be82ae3c1","type":"text","conversion_output":true,"text":"The KOOS Symptom Index consists of the following 5 questions, to be evaluated by the subject","text_display":"\n\nThe KOOS Symptom Index consists of the following 5 questions, to be evaluated by the subject","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,370],[1347,370],[1347,423],[245,423]],"region":{"top_left_x":244,"top_left_y":369,"width":1104,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcc598a611fb470f845479f84aca55a7","type":"text","conversion_output":true,"text":"using the indicated 5-point scales with the following instructions:","text_display":" using the indicated 5-point scales with the following instructions:","confidence":0.888671875,"confidence_rate":0.9983620761126399},{"cnt":[[243,507],[1779,507],[1779,561],[243,561]],"region":{"top_left_x":242,"top_left_y":507,"width":1537,"height":54},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c9d4eea7afe471bbca5dd99c76afae9","type":"text","conversion_output":true,"text":"These questions should be answered thinking of your knee symptoms during the last week:","text_display":"\n\nThese questions should be answered thinking of your knee symptoms during the last week:","confidence":1,"confidence_rate":1},{"cnt":[[243,595],[930,595],[930,649],[243,649]],"region":{"top_left_x":242,"top_left_y":595,"width":689,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66e78aff71504e6ab3fad67121a05622","type":"text","conversion_output":true,"text":"Q1. Do you have swelling in your knee?","text_display":"\nQ1. Do you have swelling in your knee?","confidence":1,"confidence_rate":1},{"cnt":[[279,675],[1852,675],[1852,812],[279,812]],"region":{"top_left_x":279,"top_left_y":674,"width":1573,"height":139},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9ac0cc2d76a44f095809c91840fef4f","type":"table","conversion_output":true,"text":"\\begin{tabular}{ccccc} \nNever & Rarely & Sometimes & Often & Always \\\\\n\\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\)\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{ccccc} \nNever & Rarely & Sometimes & Often & Always \\\\\n\\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\)\n\\end{tabular}","confidence":1,"confidence_rate":1},{"cnt":[[245,930],[1764,930],[1764,984],[245,984]],"region":{"top_left_x":244,"top_left_y":930,"width":1520,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3690cda5ad043f3bf033410f81d12bf","type":"text","conversion_output":true,"text":"Q2. Do you feel grinding, hear clicking or any other type of noise when your knee moves?","text_display":"\n\nQ2. Do you feel grinding, hear clicking or any other type of noise when your knee moves?","confidence":1,"confidence_rate":1},{"cnt":[[275,1010],[1852,1010],[1852,1147],[275,1147]],"region":{"top_left_x":275,"top_left_y":1009,"width":1577,"height":139},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31fc2c54e3054f019c1d5bd2bd30d5ee","type":"table","conversion_output":true,"text":"\\begin{tabular}{ccccc} \nNever & Rarely & Sometimes & Often & Always \\\\\n\\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\)\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{ccccc} \nNever & Rarely & Sometimes & Often & Always \\\\\n\\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\)\n\\end{tabular}","confidence":1,"confidence_rate":1},{"cnt":[[245,1265],[1132,1265],[1132,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1265,"width":889,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebd0fa6e06e84f7fb5650a7a3a499067","type":"text","conversion_output":true,"text":"Q3. Does your knee catch or hang up when moving?","text_display":"\n\nQ3. Does your knee catch or hang up when moving?","confidence":1,"confidence_rate":1},{"cnt":[[269,1341],[1854,1341],[1854,1485],[269,1485]],"region":{"top_left_x":268,"top_left_y":1340,"width":1587,"height":145},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1696d7e350f24f269d75588195f0ae1f","type":"multiple_choice_block","conversion_output":false,"children_ids":["24f54ef264734ec6bedff6bfa2ee7624","4456db977d8244c99ea1ebe087631057","30d4ea1dff424b3e8718c963c051b308","43edeaf3fbcb46048cb3960acf3fd1c1","8eccbd90bac14056ac6226d2529c9c17"],"text":"","text_display":""},{"cnt":[[279,1349],[385,1349],[385,1480],[279,1480]],"region":{"top_left_x":279,"top_left_y":1349,"width":106,"height":132},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24f54ef264734ec6bedff6bfa2ee7624","type":"multiple_choice_option","conversion_output":false,"parent_id":"1696d7e350f24f269d75588195f0ae1f","children_ids":["667261a81b1c4b94bdfce6a69d8114dc","5e11b47accdd4ca8bbba419fd0eba307"],"text":"","text_display":""},{"cnt":[[284,1354],[380,1354],[380,1394],[284,1394]],"region":{"top_left_x":283,"top_left_y":1353,"width":98,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"667261a81b1c4b94bdfce6a69d8114dc","type":"text","conversion_output":true,"parent_id":"24f54ef264734ec6bedff6bfa2ee7624","text":"Never","text_display":"\nNever","confidence":1,"confidence_rate":1},{"cnt":[[305,1427],[357,1427],[357,1474],[305,1474]],"region":{"top_left_x":305,"top_left_y":1426,"width":52,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e11b47accdd4ca8bbba419fd0eba307","type":"form_field","conversion_output":true,"parent_id":"24f54ef264734ec6bedff6bfa2ee7624","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[619,1347],[735,1347],[735,1476],[619,1476]],"region":{"top_left_x":618,"top_left_y":1347,"width":117,"height":129},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4456db977d8244c99ea1ebe087631057","type":"multiple_choice_option","conversion_output":false,"parent_id":"1696d7e350f24f269d75588195f0ae1f","children_ids":["772c7c81fca746b3b71ee48aba67f57d","aa07b003381f493ab97ae4ff192d6c8c"],"text":"","text_display":""},{"cnt":[[627,1354],[724,1354],[724,1394],[627,1394]],"region":{"top_left_x":627,"top_left_y":1353,"width":98,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"772c7c81fca746b3b71ee48aba67f57d","type":"text","conversion_output":true,"parent_id":"4456db977d8244c99ea1ebe087631057","text":"Rarely","text_display":"\nRarely","confidence":1,"confidence_rate":1},{"cnt":[[653,1431],[698,1431],[698,1474],[653,1474]],"region":{"top_left_x":653,"top_left_y":1430,"width":46,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa07b003381f493ab97ae4ff192d6c8c","type":"form_field","conversion_output":true,"parent_id":"4456db977d8244c99ea1ebe087631057","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[967,1349],[1145,1349],[1145,1476],[967,1476]],"region":{"top_left_x":966,"top_left_y":1349,"width":180,"height":127},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30d4ea1dff424b3e8718c963c051b308","type":"multiple_choice_option","conversion_output":false,"parent_id":"1696d7e350f24f269d75588195f0ae1f","children_ids":["7cb0ef730b144a47971578d9c7868c54","de51d38c677241468a40993247c58cff"],"text":"","text_display":""},{"cnt":[[973,1354],[1137,1354],[1137,1390],[973,1390]],"region":{"top_left_x":973,"top_left_y":1353,"width":164,"height":38},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7cb0ef730b144a47971578d9c7868c54","type":"text","conversion_output":true,"parent_id":"30d4ea1dff424b3e8718c963c051b308","text":"Sometimes","text_display":"\nSometimes","confidence":1,"confidence_rate":1},{"cnt":[[1036,1431],[1079,1431],[1079,1474],[1036,1474]],"region":{"top_left_x":1035,"top_left_y":1430,"width":44,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de51d38c677241468a40993247c58cff","type":"form_field","conversion_output":true,"parent_id":"30d4ea1dff424b3e8718c963c051b308","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1388,1349],[1485,1349],[1485,1476],[1388,1476]],"region":{"top_left_x":1387,"top_left_y":1349,"width":98,"height":127},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43edeaf3fbcb46048cb3960acf3fd1c1","type":"multiple_choice_option","conversion_output":false,"parent_id":"1696d7e350f24f269d75588195f0ae1f","children_ids":["926d175df953404bbf2b7460807e5baf","bb1367939f09460092d50601c7b9a5a1"],"text":"","text_display":""},{"cnt":[[1396,1354],[1480,1354],[1480,1390],[1396,1390]],"region":{"top_left_x":1396,"top_left_y":1353,"width":85,"height":38},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"926d175df953404bbf2b7460807e5baf","type":"text","conversion_output":true,"parent_id":"43edeaf3fbcb46048cb3960acf3fd1c1","text":"Often","text_display":"\nOften","confidence":1,"confidence_rate":1},{"cnt":[[1418,1431],[1459,1431],[1459,1472],[1418,1472]],"region":{"top_left_x":1417,"top_left_y":1430,"width":42,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb1367939f09460092d50601c7b9a5a1","type":"form_field","conversion_output":true,"parent_id":"43edeaf3fbcb46048cb3960acf3fd1c1","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1729,1349],[1846,1349],[1846,1474],[1729,1474]],"region":{"top_left_x":1729,"top_left_y":1349,"width":117,"height":125},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8eccbd90bac14056ac6226d2529c9c17","type":"multiple_choice_option","conversion_output":false,"parent_id":"1696d7e350f24f269d75588195f0ae1f","children_ids":["844d7b67d3fc4870ab8098d6f95f72b5","73bfcef5b18841c385724d32ddb504fe"],"text":"","text_display":""},{"cnt":[[1732,1354],[1841,1354],[1841,1394],[1732,1394]],"region":{"top_left_x":1731,"top_left_y":1353,"width":111,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"844d7b67d3fc4870ab8098d6f95f72b5","type":"text","conversion_output":true,"parent_id":"8eccbd90bac14056ac6226d2529c9c17","text":"Always","text_display":"\nAlways","confidence":1,"confidence_rate":1},{"cnt":[[1770,1431],[1805,1431],[1805,1470],[1770,1470]],"region":{"top_left_x":1770,"top_left_y":1430,"width":35,"height":40},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73bfcef5b18841c385724d32ddb504fe","type":"form_field","conversion_output":true,"parent_id":"8eccbd90bac14056ac6226d2529c9c17","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[245,1598],[922,1598],[922,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":1598,"width":678,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39a0e2eaa78f400db3e75c5aab9062bb","type":"text","conversion_output":true,"text":"Q4. Can you straighten your knee fully?","text_display":"\n\nQ4. Can you straighten your knee fully?","confidence":1,"confidence_rate":1},{"cnt":[[275,1678],[1848,1678],[1848,1818],[275,1818]],"region":{"top_left_x":275,"top_left_y":1677,"width":1573,"height":141},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4347de86f5e049ddae09e131e60a6a32","type":"multiple_choice_block","conversion_output":false,"children_ids":["4d949c877d834fcbb587dcb3f9234f07","433d4f7330f24556b420144888c09d32","afa8e8b4d002438ab47784ac1bb3de5d","347c7d2c871d4b8994f2f70f74f81238","3fe02737374b4611ae114405ecc213cc"],"text":"","text_display":""},{"cnt":[[279,1689],[389,1689],[389,1811],[279,1811]],"region":{"top_left_x":279,"top_left_y":1688,"width":110,"height":124},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d949c877d834fcbb587dcb3f9234f07","type":"multiple_choice_option","conversion_output":false,"parent_id":"4347de86f5e049ddae09e131e60a6a32","children_ids":["755a7472f8e441a8a0b54f43ac3697ef","175a59709a244d05ad2af51d8e887701"],"text":"","text_display":""},{"cnt":[[279,1689],[389,1689],[389,1729],[279,1729]],"region":{"top_left_x":279,"top_left_y":1688,"width":110,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"755a7472f8e441a8a0b54f43ac3697ef","type":"text","conversion_output":true,"parent_id":"4d949c877d834fcbb587dcb3f9234f07","text":"Always","text_display":"\nAlways","confidence":1,"confidence_rate":1},{"cnt":[[314,1766],[357,1766],[357,1809],[314,1809]],"region":{"top_left_x":313,"top_left_y":1766,"width":44,"height":43},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"175a59709a244d05ad2af51d8e887701","type":"form_field","conversion_output":true,"parent_id":"4d949c877d834fcbb587dcb3f9234f07","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[636,1684],[728,1684],[728,1811],[636,1811]],"region":{"top_left_x":635,"top_left_y":1684,"width":94,"height":128},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"433d4f7330f24556b420144888c09d32","type":"multiple_choice_option","conversion_output":false,"parent_id":"4347de86f5e049ddae09e131e60a6a32","children_ids":["72b5530972464d3ab8264fdea6e362d6","b10db4d218d147fea924a62c6cadfa32"],"text":"","text_display":""},{"cnt":[[640,1689],[724,1689],[724,1725],[640,1725]],"region":{"top_left_x":640,"top_left_y":1688,"width":85,"height":38},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72b5530972464d3ab8264fdea6e362d6","type":"text","conversion_output":true,"parent_id":"433d4f7330f24556b420144888c09d32","text":"Often","text_display":"\nOften","confidence":1,"confidence_rate":1},{"cnt":[[662,1766],[705,1766],[705,1809],[662,1809]],"region":{"top_left_x":661,"top_left_y":1766,"width":44,"height":43},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b10db4d218d147fea924a62c6cadfa32","type":"form_field","conversion_output":true,"parent_id":"433d4f7330f24556b420144888c09d32","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[969,1687],[1145,1687],[1145,1811],[969,1811]],"region":{"top_left_x":968,"top_left_y":1686,"width":178,"height":126},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afa8e8b4d002438ab47784ac1bb3de5d","type":"multiple_choice_option","conversion_output":false,"parent_id":"4347de86f5e049ddae09e131e60a6a32","children_ids":["32825e3ab28340f889bfc6341416beed","0acbe46a86524844b1082f180f92e489"],"text":"","text_display":""},{"cnt":[[975,1689],[1139,1689],[1139,1725],[975,1725]],"region":{"top_left_x":975,"top_left_y":1688,"width":164,"height":38},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32825e3ab28340f889bfc6341416beed","type":"text","conversion_output":true,"parent_id":"afa8e8b4d002438ab47784ac1bb3de5d","text":"Sometimes","text_display":"\nSometimes","confidence":1,"confidence_rate":1},{"cnt":[[1036,1766],[1079,1766],[1079,1809],[1036,1809]],"region":{"top_left_x":1035,"top_left_y":1766,"width":44,"height":43},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0acbe46a86524844b1082f180f92e489","type":"form_field","conversion_output":true,"parent_id":"afa8e8b4d002438ab47784ac1bb3de5d","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1379,1687],[1489,1687],[1489,1811],[1379,1811]],"region":{"top_left_x":1379,"top_left_y":1686,"width":110,"height":126},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"347c7d2c871d4b8994f2f70f74f81238","type":"multiple_choice_option","conversion_output":false,"parent_id":"4347de86f5e049ddae09e131e60a6a32","children_ids":["9410c6a760f14b8982e35ceeae851d49","f98daba68672483d83460da960f048c9"],"text":"","text_display":""},{"cnt":[[1384,1689],[1482,1689],[1482,1729],[1384,1729]],"region":{"top_left_x":1383,"top_left_y":1688,"width":100,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9410c6a760f14b8982e35ceeae851d49","type":"text","conversion_output":true,"parent_id":"347c7d2c871d4b8994f2f70f74f81238","text":"Rarely","text_display":"\nRarely","confidence":1,"confidence_rate":1},{"cnt":[[1414,1764],[1454,1764],[1454,1813],[1414,1813]],"region":{"top_left_x":1413,"top_left_y":1763,"width":42,"height":51},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f98daba68672483d83460da960f048c9","type":"form_field","conversion_output":true,"parent_id":"347c7d2c871d4b8994f2f70f74f81238","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[1736,1687],[1841,1687],[1841,1809],[1736,1809]],"region":{"top_left_x":1735,"top_left_y":1686,"width":107,"height":123},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fe02737374b4611ae114405ecc213cc","type":"multiple_choice_option","conversion_output":false,"parent_id":"4347de86f5e049ddae09e131e60a6a32","children_ids":["fb73b30440044097ad97e6724d9358c4","71b99acd4e7a477383883164d8f7a564"],"text":"","text_display":""},{"cnt":[[1740,1689],[1833,1689],[1833,1725],[1740,1725]],"region":{"top_left_x":1740,"top_left_y":1688,"width":93,"height":38},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb73b30440044097ad97e6724d9358c4","type":"text","conversion_output":true,"parent_id":"3fe02737374b4611ae114405ecc213cc","text":"Never","text_display":"\nNever","confidence":1,"confidence_rate":1},{"cnt":[[1766,1766],[1811,1766],[1811,1809],[1766,1809]],"region":{"top_left_x":1766,"top_left_y":1766,"width":46,"height":43},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71b99acd4e7a477383883164d8f7a564","type":"form_field","conversion_output":true,"parent_id":"3fe02737374b4611ae114405ecc213cc","text":"","text_display":"\n□","subtype":"checkbox"},{"cnt":[[245,1934],[840,1934],[840,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1933,"width":597,"height":55},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fdf0d0fc1034cb28bdf56321c9b4cef","type":"text","conversion_output":true,"text":"Q5. Can you bend your knee fully?","text_display":"\n\nQ5. Can you bend your knee fully?","confidence":1,"confidence_rate":1},{"cnt":[[271,2015],[1837,2015],[1837,2144],[271,2144]],"region":{"top_left_x":270,"top_left_y":2015,"width":1567,"height":130},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3077b517d09e469881abbc9470b25e5f","type":"table","conversion_output":true,"text":"\\begin{tabular}{ccccc} \nAlways & Often & Sometimes & Rarely & Never \\\\\n\\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\)\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{ccccc} \nAlways & Often & Sometimes & Rarely & Never \\\\\n\\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\) & \\(\\square\\)\n\\end{tabular}","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0cc0feadbb0458183ad2847ed32b48e","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1491,2531],[1601,2531],[1601,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2530,"width":110,"height":34},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0843318b223749399ef8970260d94bba","type":"page_info","conversion_output":false,"text":"108/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2589],[245,2589]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":41},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"787b57c860bd4f1083d11d6b4e293168","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[440,2512],[507,2512],[507,2548],[440,2548]],"region":{"top_left_x":440,"top_left_y":2511,"width":68,"height":38},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12647dff76004334a4328b18171ae3d5","type":"page_info","conversion_output":false,"text":"CCI","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-109","page":109,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30bf68bee9fb47d2b4f02aa7e8046e2c","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53fd9c95f46a4fefa958e91aaa7d243a","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b5c86a9bbe74d40bdd3026251cc27ad","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,277],[1207,277],[1207,346],[241,346]],"region":{"top_left_x":240,"top_left_y":277,"width":968,"height":69},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4019995e082540a0b8b7af33d4816df7","type":"section_header","conversion_output":false,"children_ids":["dfc39ac5360f4d2fab2460d71156b54c"],"text":"","text_display":""},{"cnt":[[245,284],[1205,284],[1205,342],[245,342]],"region":{"top_left_x":244,"top_left_y":283,"width":962,"height":59},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfc39ac5360f4d2fab2460d71156b54c","type":"text","conversion_output":true,"parent_id":"4019995e082540a0b8b7af33d4816df7","text":"Appendix E: Schedule of Trial Procedures","text_display":"\n\n\\section*{Appendix E: Schedule of Trial Procedures}","confidence":1,"confidence_rate":1},{"cnt":[[241,352],[397,352],[397,415],[241,415]],"region":{"top_left_x":240,"top_left_y":352,"width":158,"height":63},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"422bb24030e541cb9d9ff58a8974756c","type":"figure_label","conversion_output":false,"text":"Table 5","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[589,352],[1433,352],[1433,408],[589,408]],"region":{"top_left_x":588,"top_left_y":352,"width":846,"height":57},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb1313a90692452ca7a8c24c08227201","type":"figure_label","conversion_output":true,"text":"Schedule of Trial Procedures for Visits 1 to 11","text_display":"\n\nSchedule of Trial Procedures for Visits 1 to 11","confidence":1,"confidence_rate":1},{"cnt":[[226,417],[1884,417],[1884,2428],[226,2428]],"region":{"top_left_x":225,"top_left_y":416,"width":1660,"height":2012},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b611a73db144d24a7c8b08f8e47019c","type":"table","conversion_output":true,"children_ids":["0321e274e483417aa1c7d792521d8f17","d44766bd7f074cd088f724ab90390661","1eed8548b86d45eda4d649bd03772c41","6b1784a8dbc94eeb8ce066c04f635636","c11e942d03854c1b8758655394410b21","de480d4f6e0a46a38b86c5d8f19e513f","c94987785b994a97aeec3ea2b8be6ddf","ac8bbb99c1a144dcbc84f5d81a958330","c7332ed9c71e46b5b9b7f30aa80a647d","16dc67562f9c44a3a7c9681ee4a5e4c7","0f492c32cf664eea8412c47c00c571ec","ccc660e839be4899a675d77d15eb4620","c56c619cbf3e45b29673a62135eba3b5","b8b4cbc0cc8e4909a08e6f06c590e6e8","240a89386e64499b81cbb6f21a1544e6","5bf778c4f4464f03afd4418fec6029cf","5fb7584036fd4a1bbcb13b18c278dcd0","06cdd04d835842c2ace0b95632b3cab5","f63663480c0b4f0c9e4b0b13025d5af6","178751669efb4638aa9bc9be9229c3e3","1b6f592ce79a484e81018d0bb6787b62","77fb2249222c4728b1ab7ea5e94b50e5","ef8721b61cdb4a01b4a62e514f4870e2","fa64c64f60c54e7ab338deb4980f506b","c54a41e66b974f6cbd1c25c0b1e1f198","d61197f82e554a9abe36102f994de1e1","d890274ccb95488095deeae5ea81a90a","ae2c9815de934b5c8e5514c213972786","016ca77fa59b43ab967d9ff4fc814cb1","8371da4e71d14264ab4ffa3f720a932a","e6d7c0f45fe74b7fa9e89703d9f77634","70c8673dd82b429580a3127a5309589a","c4f060e63a96478f8345ade4e9dda2bb","80d3038881624968805f49fca4f2a02d","f9e35df9ad9846bfbdd7af580b9c53bd","0de4d94ced7b4ad68cbca8c1dd103557","b80d1f113d1c4ec69313b488b27b1ce0","2bd1e9b72461491ba5a64ea868fd094b","726f6331152c4a289770d0a9f1f75453","2e883245070f4fce93d3076460f4741c","4c87cbf754854097a8ecc7dbcece3ba8","1e15708e56624dd384e7d0a4de101635","0328545a88684bfda15e8cf3b826050f","c2c852bdbf5b4691a3cb71ed22981d38","e47db6ba3bf8401181b2ec0941431e4e","ce31bff7369342558c7c7d6420fc1029","6448d4aef2534dcdbbe1871665dbb9e7","feeea209e1544be28e4c25d09e4903e5","335037e6b8c54f8c88d3c4d12e4f2183","c298007771ce4786b26c3b283f3a850e","265ba5d2c1854c0ea98341f980417c6c","7941c3bae65c48a283a25bb4a97d3284","5b3366b28ad24ea9827551ffbf78cb45","1fd62e05ac8947a086b5c522a09a1b3c","d8bc2443c871405a98eca9183f808dff","6da17cf86e7d41c79af28cd9ae36b960","782a1453215c4e88bcd3a5e4083b8f96","671c1f1922954ce6ab2adde88e5d517b","719ff35d007849518d4c0a4c5f48911f","efd2cb5df4844116bd0f4cfe06deee90","11053cfea3244fd7a85bd182779404e7","a355345060ad4bfb8636d40c846eaa8a","163523b0502049e395e77cf6d1c1b310","b54a3e9b41254b19ab87bba79a2c9115","64beefa5f12d4980a62439eaa718a319","c1114b62bf844fddb65f653ad8f2ab7f","62e8ae94becb4b63bf2d4c12a4ddd8df","d454235405a74203a26e00ac3a6910e3","a7a8c0fb8b2140c8a6f901518d14d791","1d5c5c8a6d3c479c8169184de7032a47","28a274a225024f919a2bc1714c0eaa31","81ce0c17c8614dc988dda48414dfb2dd","a97c48a605ca4f848335c9e35d3ab76f","1ca69c5c55a74b7995e3d90550a5ebe3","17d2d4ad190b463e88004a442428827f","d4d9f2f2e7f84173bfe55c4c31c205d4","b57a877a614840659e64eb0a6712f8b6","e44e73be610d4e62a7b84ada6cfe9402","24bbe9611471469f9326d422be190244","abcd3f884767417591cb1b215ac4f987","f1e58dab26c14ebba27b464e86fb70f8","268dd220038542edb2fab7bff4ca57bb","5392abdb4edc471d994da1ab96ce7ca6","bd758511eb2e4a53a8a7693262644f04","e7bba678b9aa44ce93782d480f962244","a0c040b059ba409db1e103fcc101c885","fe1d26cc25b0426ab66753e1a65fe5e8","0f6c57e960954b09932636ff0361afb8","0ae9972fd7d3488db0f0a68be1dce438","969bd24f2ace431da9a6d700ebb0af6d","0e330b8ec0764a1c818c2e718b21d6ec","27f4d8661ea64367892f1e7aa917c538","3af5c4976a994942a23ffba314b6df6b","2d6679a7745948d98a5cd926936f3504","007dde4178d24f28b264f1db5a134c40","6e9b1c0abb814fa999cd8001834e0136","d63b0059f8f64244976142cd3b9747a1","c81831bbbfd24d80bcfbd8ad18dd8e24","422ef98951a748b6853566e0981dc142","527ac93a39bf4656b1669a3723c57994","6585cd051c054731b694d10028eeee33","87e5c50e30764a56a366920d531ce997","43b019f2c5744a56957cd00445cd8ccd","e5d964d23a1b446cbc808b57b35a845e","7aa40ec0501545b1ad6f0b6a84c852e7","f67d9a85f5454af49af453064822c442","a4b5ddfbdfe6434a8d4a34322166bbce","b3fe3d9362fb4a17b4f815a73fe6504a","0c0986d9edbb4b35988418372aba423b","39d925033d2d497daa2824a9a7951a3d","91d24f4472fb445c90d543753ff3ad14","98ce482b24074a05b3e2fe62675e11e0","399a5a274bde474b83776fd70701736c","7ab0cd5d0668465f85b92d6973586f3a","351c10e406d94245b10431c76d5ab0d7","2b1dfa8cf6fb42be8a1db47158c9a3a8","b1599beadcfd4f94a6dceb9943908ebd","1b6b74c71ff54a1285e71f2a87c1a2e3","7e6b6e4193e9439aac056827b71dbef4","9eee232312b54663aa66200ab185bf84","99adb8246af543cca7af0927a5df204c","89ec18e8c0154ed68f82652be8cae9fa","a2d40224958b4b638d12a69640c0df7b","d58f2f3c64694a31b349d9590cedb8e9","a838777e48504738959f20d81e247f13","13bd9a4e12114263bdb4bf605b746324","802bdcd0c81b4e2eb7227b6b812079d8","e88b0ec112ee457f83aa8c018e19809b","8cc371411f3b4f4bb79480d9894cf395","98c1edae898143d8bdfa741a20b2b2b5","28b5901228534370a49623eaad850786","312bfc565b43443d8f2ffe4f7fd5cd22","8c97bb72fa384ec78b5e669463cd1ec2","3adc17e3fc3f423dbe50e5be8f55d1f6","322f4d87d1ec4f2bbc6c152b9064d50b","b46c01a14b074367a351c8067e5dc57d","64c9753192784fcd9a6b5bddec4c0998","fb3a5ae88c70492784bea9bcc5ecc0db","1880ffbf84934a138104e04a9ee000d6","726ed3d3e010409dabcec6c4c3bce7bc","541dcfa58eaf46fd978ba5069353e2ee","aaef6a09514646d5aae7309b7c069d7d","feb178abc8b64b22813d8cff6a9298dc","49e497e982e047a5a3daf01f008b38b6","ade3121ffbf24bcc9b0b0d4000bf376a","62aee2fc31e9439f9b66f208b4a63f02","62813d4892b74561b8da62af8025d00d","2811eedf553d45b292e12b53d0f06d6e","c7464905a9fe471480754e414a5a422d","7ab15f3be6f24da3a22de53d29dea454","d11debdbcf7a4188af4f5b9a6f47961b","01273652d4bd49d49dd08bc4fd01acf5","75f6e7e998b84342a92554065676b89f","bee93502c94a42988e1c973c8976acdc","ff66e1d6668e476491b96bab4b543e49","cc4513e8b30f4fc7be83a35136c43aa5","54bafeeae7834b028eaf12f8121b818d","2d317d33f93246dea3b877c62de59157","ed8d8dca52e64b3998a75103d17694d6","58b41f330aed46698e9a943b26065861","73661f771a2d4d1b8b30ac6c2a3a0dd9","81b46b265d5f4e838b8ca4f9b371a963","e6919e04a4a54e1d876f0c8db3507c32","cc40a3d60aeb406caf97316666260315","0d970ea9283a409b82e1ea0c2a4c59dc","a68f2adc18c74cba9dd523299f01bd30","46870aa0c8ea429c84d19232e69004ed","097979d70f7a4193a155924fd41c279b","8dc069d7a226459a884bc03b69899b8a","972ca00e21b5442d95ac4e81035d8178","4e2dd9d6abc1454ba2b3369f37422b05","a88964ccdd5247c0a472a2496e0a3232","c36d1a5f3a274e77916231e276df91c8","e48c1f6d4c6b40f4a7bd3790d439b7ea","1ea101f033e34db09eaa6b1d6f6f46bb","b183c16230964b21a3c78cd50da3cbca","146931f8f5e24c7eb1280cdb163f7cdf","0fb1999005d04193bcb5d4da5d886c99","1e6036a6da23445eb89e98763586f0c4","5153ea9570c5416999392a1e984c4d06","53930665ce084989a645c5c410808866","dc3630fbfba24f7ba4680c1cae07919f","9c489a1c21b74752be92ca6618d7e434","af4a373b157e43318287541f0d11b81f","60b11ce092624ecb82c17cd63f9b1754","749689d9609642d6803cc2e3efc35412","4b0efab96faa4d2abd651979147a558a","707ddaf94c3f4ef0a1a75496f63f526f","46fdbd7036e845709fe17e28a961e59f","5e8c2936968c45198f329b57797121c9","c5dd473ab9e0444b962e33ec8cdbafff","b749e928f9d145a9ad67be10ecb6da29","8a53f473f636433bba1985731f7b44e5","aa5f4e2fe19249f2a71a9537da44e424","5f1d83aabfa741658fbe354636ad7332","f98951b6557543eaae390acb66cee1e8","d790f75f9bd641f1865ffb64ed29cf12","016e554c2d9f4dbe81b359805ec2ffab","ea3b665d170a4b899e37fd75a96e061f","544565a52693467a800637a7e3b76c8b","d100128d3832494092990b2f950375dc","4a631eb13eab4f369fcf798273c11bc2","6ad1553b7b9d484982c78149b913d48d","9cc74bd0dfce46b982de7d05b7207050","49b36a2ac5ba4c8ba5469622933df737","52e3e2b7072d4543968134ec3c24ccf3","e4cce017e77348c188397df13f6a4e9e","988cc2616df24fc8b883ead123e60bff","32f80c6179504bfbad37aebfa7bbcde6","4359ab1ce78749af8b8b949a301a01bb","30a73036791b40ffa5df4d1cfc2bd18b","5084083d8ac049799373cc7e2d4f1a50","dcaaf6d08ea4435889c2e5b987bde9aa","02a79d7807ac4f1281d7000570595b13","d6e49c87dfc04c1381478d07e688fe14","2740f7a7e428401b8fd336ce83d792a5","96ec3b1d580f4be295e3560b77be3896","cc84ae530aa74cb9ab0e37a0059d8145","4e5219bb0682415a8c6d9a3050bd20ee","e326e3df00cf4e2f9b503b0615155a51","9db9ac3db849435ba6e0b63456fca51d","e7542a04320a40858cd35b1f4bd56070","96f03c43c3b0458c939c76d4f7b1186a","420efebb709a4338b1527355bfcf25f6","f06c2b9938c343aab4dcc73dd98535ce","9b7a625e43b34742b329d2344192f4c8","69526f6a22ca4f5baf969428891f2a79","2917dc67050c4f78809baea799b6bfd2","f37f8806ba0e4defa68a28380101cf42","6700883fe0fb402aacbe2dee3397d481","808acc0a797d4814b4904181ac2e4de4"],"selected_labels":["422bb24030e541cb9d9ff58a8974756c","fb1313a90692452ca7a8c24c08227201"],"text":"\\begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|l|l|l|}\n\\hline \\multirow[t]{2}{*}{Visit} & \\multicolumn{2}{|c|}{Screening \\({ }^{(1)}\\)} & \\multicolumn{2}{|c|}{Baseline} & \\multirow{2}{*}{V3} & \\multirow{2}{*}{V4} & \\multirow{2}{*}{V5} & \\multirow{2}{*}{V6} & \\multirow{2}{*}{V7} & \\multirow{2}{*}{V8} & \\multirow{2}{*}{V9} & \\multirow{2}{*}{V10} & \\multirow{2}{*}{V11} \\\\\n\\hline & V1a & V1b & V2 & & & & & & & & & & \\\\\n\\hline Week \\({ }^{ ( 2 ) }\\) & \\multicolumn{2}{|c|}{-42 to -4 days} & \\multicolumn{2}{|c|}{\\(0^{(3)}\\)} & 1 & 2 & 3 & 12 & 26 & 27 & 28 & 29 & 38 \\\\\n\\hline Informed consents \\({ }^{(4)}\\) & X & & & & & & & & & & & & \\\\\n\\hline Demographics & X & & & & & & & & & & & & \\\\\n\\hline Medical/medication history & X & & & & & & & & & & & & \\\\\n\\hline Inclusion/Exclusion criteria & X & X & X & & & & & & & & & & \\\\\n\\hline Withdraw analgesia prior to visit \\({ }^{(5)}\\) & & X & X & & & & & X & X & & & & X \\\\\n\\hline Identification of target knee & & X & & & & & & & & & & & \\\\\n\\hline Randomization & & & & X & & & & & & & & & \\\\\n\\hline WOMAC (question 1 only) & X & X & & & & & & & & & & & \\\\\n\\hline WOMAC (full questionnaire) & & & X & & & & & X & x & & & & X \\\\\n\\hline Patient's Global Assessment & X & & X & & & & & X & X & & & & X \\\\\n\\hline KOOS QOL and Symptom Index & & & X & & & & & X & X & & & & X \\\\\n\\hline PGIC & & & & & & & & X & X & & & & X \\\\\n\\hline Pain NRS both knees & X & X & X & & & & & X & X & & & & X \\\\\n\\hline Pain in other joints & & & X & & & & & & X & & & & \\\\\n\\hline MOS SF-36 & & & X & & & & & & X & & & & \\\\\n\\hline ICOAP & & & X & & & & & X & X & & & & X \\\\\n\\hline AEs & \\multicolumn{13}{|c|}{Continuous} \\\\\n\\hline Concomitant medications & \\multicolumn{13}{|c|}{Continuous} \\\\\n\\hline Surgical procedures (target knee) & \\multicolumn{13}{|c|}{Continuous} \\\\\n\\hline Review of subject diaries & & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline Vital signs \\({ }^{(6)}\\) & & X & & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline Physical examination \\({ }^{(7)}\\) & & X & & & & & & X & X & & & & \\\\\n\\hline ECG & & X & & & & & & & & & & & \\\\\n\\hline Clinical laboratory specimens \\({ }^{(8)}\\) & & X & & X & & & & & X & & & & \\\\\n\\hline Antibodies to sprifermin/FGF-18 & & & & X & & & X & & X & & & X & \\\\\n\\hline PK serum collection \\({ }^{(9)}\\) & & & & X & & X & & & & & X & & \\\\\n\\hline Biomarker serum collection \\({ }^{(10)}\\) & & & & X & & & & & & & X & & \\\\\n\\hline Biomarker urine collection & & & & X & & & & & & & X & & \\\\\n\\hline PGt sample collection \\({ }^{(11)}\\) & \\multicolumn{13}{|c|}{One sample needed. Can be obtained at any trial visit, preferably at baseline.} \\\\\n\\hline Pregnancy test \\({ }^{(12)}\\) & & X & & X & X & X & & & X & X & X & & \\\\\n\\hline 20-meter walk test & & X & X & & & & & X & X & & & & X \\\\\n\\hline Knee X-ray(s) \\({ }^{(13)(14)}\\) & & X & & & & & & & & & & & \\\\\n\\hline Target knee MRI \\({ }^{(3)(14)}\\) & & & & X & & & & & X & & & & \\\\\n\\hline Synovial fluid collection \\({ }^{(15)}\\) & & & & X & X & X & & & X & X & X & & \\\\\n\\hline i.a. injection of IMP & & & & X & X & X & & & X & X & X & & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 5}\n\\begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|l|l|l|}\n\\hline \\multirow[t]{2}{*}{Visit} & \\multicolumn{2}{|c|}{Screening \\({ }^{(1)}\\)} & \\multicolumn{2}{|c|}{Baseline} & \\multirow{2}{*}{V3} & \\multirow{2}{*}{V4} & \\multirow{2}{*}{V5} & \\multirow{2}{*}{V6} & \\multirow{2}{*}{V7} & \\multirow{2}{*}{V8} & \\multirow{2}{*}{V9} & \\multirow{2}{*}{V10} & \\multirow{2}{*}{V11} \\\\\n\\hline & V1a & V1b & V2 & & & & & & & & & & \\\\\n\\hline Week \\({ }^{ ( 2 ) }\\) & \\multicolumn{2}{|c|}{-42 to -4 days} & \\multicolumn{2}{|c|}{\\(0^{(3)}\\)} & 1 & 2 & 3 & 12 & 26 & 27 & 28 & 29 & 38 \\\\\n\\hline Informed consents \\({ }^{(4)}\\) & X & & & & & & & & & & & & \\\\\n\\hline Demographics & X & & & & & & & & & & & & \\\\\n\\hline Medical/medication history & X & & & & & & & & & & & & \\\\\n\\hline Inclusion/Exclusion criteria & X & X & X & & & & & & & & & & \\\\\n\\hline Withdraw analgesia prior to visit \\({ }^{(5)}\\) & & X & X & & & & & X & X & & & & X \\\\\n\\hline Identification of target knee & & X & & & & & & & & & & & \\\\\n\\hline Randomization & & & & X & & & & & & & & & \\\\\n\\hline WOMAC (question 1 only) & X & X & & & & & & & & & & & \\\\\n\\hline WOMAC (full questionnaire) & & & X & & & & & X & x & & & & X \\\\\n\\hline Patient's Global Assessment & X & & X & & & & & X & X & & & & X \\\\\n\\hline KOOS QOL and Symptom Index & & & X & & & & & X & X & & & & X \\\\\n\\hline PGIC & & & & & & & & X & X & & & & X \\\\\n\\hline Pain NRS both knees & X & X & X & & & & & X & X & & & & X \\\\\n\\hline Pain in other joints & & & X & & & & & & X & & & & \\\\\n\\hline MOS SF-36 & & & X & & & & & & X & & & & \\\\\n\\hline ICOAP & & & X & & & & & X & X & & & & X \\\\\n\\hline AEs & \\multicolumn{13}{|c|}{Continuous} \\\\\n\\hline Concomitant medications & \\multicolumn{13}{|c|}{Continuous} \\\\\n\\hline Surgical procedures (target knee) & \\multicolumn{13}{|c|}{Continuous} \\\\\n\\hline Review of subject diaries & & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline Vital signs \\({ }^{(6)}\\) & & X & & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline Physical examination \\({ }^{(7)}\\) & & X & & & & & & X & X & & & & \\\\\n\\hline ECG & & X & & & & & & & & & & & \\\\\n\\hline Clinical laboratory specimens \\({ }^{(8)}\\) & & X & & X & & & & & X & & & & \\\\\n\\hline Antibodies to sprifermin/FGF-18 & & & & X & & & X & & X & & & X & \\\\\n\\hline PK serum collection \\({ }^{(9)}\\) & & & & X & & X & & & & & X & & \\\\\n\\hline Biomarker serum collection \\({ }^{(10)}\\) & & & & X & & & & & & & X & & \\\\\n\\hline Biomarker urine collection & & & & X & & & & & & & X & & \\\\\n\\hline PGt sample collection \\({ }^{(11)}\\) & \\multicolumn{13}{|c|}{One sample needed. Can be obtained at any trial visit, preferably at baseline.} \\\\\n\\hline Pregnancy test \\({ }^{(12)}\\) & & X & & X & X & X & & & X & X & X & & \\\\\n\\hline 20-meter walk test & & X & X & & & & & X & X & & & & X \\\\\n\\hline Knee X-ray(s) \\({ }^{(13)(14)}\\) & & X & & & & & & & & & & & \\\\\n\\hline Target knee MRI \\({ }^{(3)(14)}\\) & & & & X & & & & & X & & & & \\\\\n\\hline Synovial fluid collection \\({ }^{(15)}\\) & & & & X & X & X & & & X & X & X & & \\\\\n\\hline i.a. injection of IMP & & & & X & X & X & & & X & X & X & & \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.5,"confidence_rate":0.99896263353753},{"cnt":[[244,416],[723,416],[723,2428],[244,2428]],"region":{"top_left_x":244,"top_left_y":416,"width":480,"height":2012},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0321e274e483417aa1c7d792521d8f17","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[764,416],[842,416],[844,2428],[766,2428]],"region":{"top_left_x":764,"top_left_y":415,"width":81,"height":2013},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d44766bd7f074cd088f724ab90390661","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[872,416],[950,416],[950,2428],[872,2428]],"region":{"top_left_x":872,"top_left_y":416,"width":79,"height":2012},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1eed8548b86d45eda4d649bd03772c41","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[987,416],[1041,416],[1041,2428],[987,2428]],"region":{"top_left_x":987,"top_left_y":416,"width":55,"height":2012},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b1784a8dbc94eeb8ce066c04f635636","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1080,416],[1080,420],[1083,422],[1083,429],[1085,431],[1083,433],[1085,435],[1085,440],[1087,442],[1087,444],[1085,446],[1085,455],[1087,457],[1087,466],[1085,468],[1085,474],[1087,477],[1087,479],[1085,481],[1085,485],[1083,487],[1083,492],[1085,494],[1085,507],[1087,509],[1087,552],[1085,555],[1085,557],[1087,559],[1087,568],[1085,570],[1085,576],[1087,578],[1087,583],[1085,585],[1085,594],[1087,596],[1087,600],[1085,602],[1085,604],[1083,607],[1083,609],[1085,611],[1085,628],[1087,630],[1087,635],[1085,637],[1085,646],[1087,648],[1087,652],[1085,654],[1085,674],[1083,676],[1083,678],[1085,680],[1085,691],[1083,693],[1085,695],[1085,698],[1087,700],[1087,704],[1085,706],[1085,726],[1083,728],[1083,730],[1085,732],[1085,743],[1083,745],[1083,747],[1087,752],[1087,760],[1085,762],[1085,775],[1083,778],[1083,784],[1085,786],[1085,788],[1087,791],[1085,793],[1085,804],[1087,806],[1087,812],[1085,814],[1085,830],[1083,832],[1085,834],[1085,836],[1087,838],[1087,847],[1085,849],[1085,851],[1087,853],[1087,864],[1085,866],[1085,873],[1087,875],[1087,879],[1085,882],[1085,886],[1087,888],[1087,899],[1085,901],[1087,903],[1087,983],[1085,986],[1085,994],[1087,996],[1087,999],[1085,1001],[1085,1012],[1087,1014],[1087,1018],[1085,1020],[1085,1044],[1087,1046],[1087,1055],[1085,1057],[1085,1059],[1087,1061],[1087,1074],[1085,1076],[1085,1081],[1087,1083],[1087,1085],[1085,1087],[1085,1096],[1087,1098],[1087,1105],[1085,1107],[1085,1113],[1087,1115],[1087,1126],[1085,1128],[1085,1135],[1087,1137],[1085,1139],[1085,1148],[1087,1150],[1087,1157],[1085,1159],[1085,1165],[1087,1167],[1087,1178],[1085,1180],[1085,1185],[1087,1187],[1087,1191],[1085,1193],[1085,1202],[1087,1204],[1087,1206],[1085,1209],[1085,1217],[1087,1219],[1087,1230],[1085,1232],[1085,1237],[1087,1239],[1087,1241],[1085,1243],[1085,1252],[1087,1254],[1087,1263],[1085,1265],[1085,1267],[1087,1269],[1087,1295],[1085,1297],[1085,1304],[1087,1306],[1087,1313],[1085,1315],[1085,1321],[1087,1323],[1087,1336],[1085,1338],[1085,1341],[1087,1343],[1087,1347],[1085,1349],[1085,1356],[1087,1358],[1087,1399],[1085,1401],[1085,1408],[1087,1410],[1087,1416],[1085,1419],[1085,1447],[1087,1449],[1085,1451],[1085,1460],[1087,1462],[1087,1466],[1085,1468],[1085,1471],[1083,1473],[1083,1475],[1085,1477],[1085,1481],[1087,1484],[1085,1486],[1085,1497],[1087,1499],[1087,1501],[1085,1503],[1085,1514],[1087,1516],[1087,1518],[1085,1520],[1085,1549],[1087,1551],[1087,1553],[1085,1555],[1085,1564],[1087,1566],[1087,1570],[1085,1572],[1085,1583],[1087,1585],[1087,1588],[1085,1590],[1085,1603],[1087,1605],[1085,1607],[1085,1616],[1087,1618],[1087,1624],[1085,1627],[1085,1633],[1087,1635],[1087,1646],[1085,1648],[1087,1650],[1087,1659],[1085,1661],[1085,1678],[1083,1681],[1083,1685],[1085,1687],[1085,1698],[1083,1700],[1083,1704],[1085,1707],[1085,1709],[1083,1711],[1083,1717],[1085,1720],[1085,1722],[1087,1724],[1087,1726],[1085,1728],[1085,1761],[1083,1763],[1083,1769],[1085,1772],[1085,1791],[1087,1793],[1087,1795],[1085,1798],[1085,1811],[1087,1813],[1085,1815],[1085,1824],[1087,1826],[1087,1832],[1085,1834],[1085,1841],[1087,1843],[1087,1867],[1085,1869],[1085,1876],[1087,1878],[1087,1882],[1085,1884],[1085,1893],[1087,1895],[1087,1917],[1085,1919],[1085,1928],[1087,1930],[1087,1936],[1085,1938],[1085,1945],[1087,1947],[1087,1956],[1085,1958],[1085,1964],[1087,1966],[1087,1969],[1085,1971],[1085,1982],[1087,1984],[1087,1986],[1085,1988],[1085,1999],[1087,2001],[1087,2005],[1085,2008],[1085,2016],[1087,2018],[1087,2021],[1085,2023],[1085,2038],[1083,2040],[1083,2060],[1080,2062],[1080,2073],[1078,2075],[1078,2081],[1080,2083],[1080,2088],[1078,2090],[1078,2099],[1080,2101],[1080,2103],[1083,2105],[1083,2120],[1085,2122],[1085,2125],[1083,2127],[1083,2133],[1085,2135],[1085,2146],[1083,2148],[1083,2153],[1085,2155],[1085,2164],[1083,2166],[1083,2170],[1085,2172],[1085,2177],[1083,2179],[1083,2185],[1085,2187],[1085,2198],[1083,2200],[1083,2205],[1085,2207],[1085,2213],[1083,2216],[1083,2222],[1085,2224],[1085,2229],[1083,2231],[1083,2237],[1085,2239],[1085,2242],[1087,2244],[1087,2246],[1085,2248],[1085,2265],[1083,2267],[1083,2274],[1085,2276],[1085,2283],[1083,2285],[1083,2289],[1085,2291],[1085,2293],[1087,2296],[1087,2298],[1085,2300],[1085,2311],[1087,2313],[1087,2317],[1085,2319],[1085,2328],[1087,2330],[1087,2332],[1085,2335],[1085,2343],[1087,2345],[1087,2350],[1085,2352],[1085,2363],[1087,2365],[1087,2367],[1085,2369],[1085,2382],[1087,2384],[1085,2387],[1085,2395],[1087,2397],[1087,2402],[1085,2404],[1085,2423],[1089,2428],[1117,2428],[1119,2426],[1122,2426],[1122,2415],[1119,2413],[1122,2410],[1122,2402],[1119,2400],[1119,2395],[1122,2393],[1122,2380],[1119,2378],[1122,2376],[1122,2361],[1119,2358],[1122,2356],[1122,2239],[1119,2237],[1122,2235],[1122,2222],[1119,2220],[1122,2218],[1122,2194],[1119,2192],[1119,2164],[1122,2161],[1122,2142],[1119,2140],[1119,2135],[1122,2133],[1122,2125],[1119,2122],[1119,2120],[1122,2118],[1122,2073],[1119,2070],[1119,2066],[1122,2064],[1122,1941],[1124,1938],[1124,1936],[1122,1934],[1122,1871],[1124,1869],[1122,1867],[1122,1789],[1119,1787],[1119,1785],[1122,1782],[1122,1780],[1119,1778],[1119,1769],[1122,1767],[1122,1741],[1119,1739],[1119,1733],[1122,1730],[1122,1728],[1119,1726],[1119,1700],[1122,1698],[1122,1455],[1124,1453],[1124,1451],[1122,1449],[1122,1403],[1124,1401],[1124,1399],[1122,1397],[1122,1369],[1124,1367],[1124,1364],[1122,1362],[1122,572],[1124,570],[1124,568],[1122,565],[1122,468],[1124,466],[1122,464],[1122,459],[1124,457],[1124,448],[1122,446],[1122,442],[1124,440],[1124,416]],"region":{"top_left_x":1078,"top_left_y":416,"width":46,"height":2012},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c11e942d03854c1b8758655394410b21","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1201,416],[1203,554],[1208,2079],[1208,2081],[1201,2425],[1199,2427],[1158,2427],[1153,2423],[1151,2111],[1151,1438],[1153,535],[1156,416]],"region":{"top_left_x":1151,"top_left_y":416,"width":57,"height":2011},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de480d4f6e0a46a38b86c5d8f19e513f","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1228,2428],[1232,416],[1282,416],[1278,2428]],"region":{"top_left_x":1227,"top_left_y":415,"width":55,"height":2013},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c94987785b994a97aeec3ea2b8be6ddf","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1308,2428],[1310,416],[1364,416],[1362,2428]],"region":{"top_left_x":1307,"top_left_y":415,"width":57,"height":2013},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac8bbb99c1a144dcbc84f5d81a958330","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1390,416],[1436,416],[1436,2428],[1390,2428]],"region":{"top_left_x":1390,"top_left_y":416,"width":46,"height":2012},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7332ed9c71e46b5b9b7f30aa80a647d","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1515,416],[1517,441],[1519,2079],[1519,2083],[1515,2423],[1511,2427],[1470,2427],[1465,2425],[1463,2115],[1463,2105],[1465,539],[1467,416]],"region":{"top_left_x":1463,"top_left_y":416,"width":56,"height":2011},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16dc67562f9c44a3a7c9681ee4a5e4c7","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1546,416],[1591,416],[1591,2428],[1546,2428]],"region":{"top_left_x":1545,"top_left_y":416,"width":47,"height":2012},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f492c32cf664eea8412c47c00c571ec","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1620,416],[1674,416],[1674,2428],[1620,2428]],"region":{"top_left_x":1619,"top_left_y":416,"width":55,"height":2012},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccc660e839be4899a675d77d15eb4620","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1700,416],[1771,416],[1771,2428],[1700,2428]],"region":{"top_left_x":1699,"top_left_y":416,"width":73,"height":2012},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c56c619cbf3e45b29673a62135eba3b5","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1793,416],[1862,416],[1862,2428],[1793,2428]],"region":{"top_left_x":1792,"top_left_y":416,"width":71,"height":2012},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8b4cbc0cc8e4909a08e6f06c590e6e8","type":"table_column","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[305,422],[1879,424],[1885,428],[1885,452],[1879,457],[1784,463],[1541,465],[662,470],[348,470],[225,467],[225,424],[248,422]],"region":{"top_left_x":225,"top_left_y":422,"width":1660,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"240a89386e64499b81cbb6f21a1544e6","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[1803,461],[1842,463],[1879,472],[1885,489],[1885,517],[1881,522],[225,522],[225,478],[1153,463],[1294,461]],"region":{"top_left_x":225,"top_left_y":461,"width":1660,"height":61},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5bf778c4f4464f03afd4418fec6029cf","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,531],[1886,531],[1886,613],[225,613]],"region":{"top_left_x":225,"top_left_y":530,"width":1661,"height":84},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fb7584036fd4a1bbcb13b18c278dcd0","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,615],[1886,615],[1886,663],[225,663]],"region":{"top_left_x":225,"top_left_y":615,"width":1661,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06cdd04d835842c2ace0b95632b3cab5","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,672],[1886,672],[1886,717],[225,717]],"region":{"top_left_x":225,"top_left_y":671,"width":1661,"height":47},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f63663480c0b4f0c9e4b0b13025d5af6","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,723],[1886,723],[1886,769],[225,769]],"region":{"top_left_x":225,"top_left_y":723,"width":1661,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"178751669efb4638aa9bc9be9229c3e3","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,773],[1886,773],[1886,819],[225,819]],"region":{"top_left_x":225,"top_left_y":773,"width":1661,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b6f592ce79a484e81018d0bb6787b62","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,819],[1886,819],[1886,873],[225,873]],"region":{"top_left_x":225,"top_left_y":818,"width":1661,"height":55},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77fb2249222c4728b1ab7ea5e94b50e5","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,875],[1886,875],[1886,925],[225,925]],"region":{"top_left_x":225,"top_left_y":875,"width":1661,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef8721b61cdb4a01b4a62e514f4870e2","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,927],[1886,927],[1886,973],[225,973]],"region":{"top_left_x":225,"top_left_y":927,"width":1661,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa64c64f60c54e7ab338deb4980f506b","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,979],[1886,979],[1886,1029],[225,1029]],"region":{"top_left_x":225,"top_left_y":979,"width":1661,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c54a41e66b974f6cbd1c25c0b1e1f198","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1031],[1886,1031],[1886,1081],[225,1081]],"region":{"top_left_x":225,"top_left_y":1030,"width":1661,"height":51},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d61197f82e554a9abe36102f994de1e1","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1083],[1886,1083],[1886,1128],[225,1128]],"region":{"top_left_x":225,"top_left_y":1082,"width":1661,"height":47},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d890274ccb95488095deeae5ea81a90a","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1135],[1886,1135],[1886,1183],[225,1183]],"region":{"top_left_x":225,"top_left_y":1134,"width":1661,"height":49},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae2c9815de934b5c8e5514c213972786","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1187],[1884,1187],[1884,1228],[225,1228]],"region":{"top_left_x":225,"top_left_y":1186,"width":1659,"height":43},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"016ca77fa59b43ab967d9ff4fc814cb1","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1239],[1886,1239],[1886,1280],[225,1280]],"region":{"top_left_x":225,"top_left_y":1238,"width":1661,"height":43},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8371da4e71d14264ab4ffa3f720a932a","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1291],[1886,1291],[1886,1336],[225,1336]],"region":{"top_left_x":225,"top_left_y":1290,"width":1661,"height":47},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6d7c0f45fe74b7fa9e89703d9f77634","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1343],[1886,1343],[1886,1388],[225,1388]],"region":{"top_left_x":225,"top_left_y":1342,"width":1661,"height":47},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70c8673dd82b429580a3127a5309589a","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1393],[1886,1393],[1886,1440],[225,1440]],"region":{"top_left_x":225,"top_left_y":1392,"width":1661,"height":49},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4f060e63a96478f8345ade4e9dda2bb","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1447],[1886,1447],[1886,1486],[225,1486]],"region":{"top_left_x":225,"top_left_y":1446,"width":1661,"height":40},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80d3038881624968805f49fca4f2a02d","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1499],[1886,1499],[1886,1538],[225,1538]],"region":{"top_left_x":225,"top_left_y":1498,"width":1661,"height":40},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9e35df9ad9846bfbdd7af580b9c53bd","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1551],[1886,1551],[1886,1596],[225,1596]],"region":{"top_left_x":225,"top_left_y":1550,"width":1661,"height":47},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0de4d94ced7b4ad68cbca8c1dd103557","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1598],[1886,1598],[1886,1648],[225,1648]],"region":{"top_left_x":225,"top_left_y":1598,"width":1661,"height":51},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b80d1f113d1c4ec69313b488b27b1ce0","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1646],[1886,1646],[1886,1700],[225,1700]],"region":{"top_left_x":225,"top_left_y":1645,"width":1661,"height":56},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bd1e9b72461491ba5a64ea868fd094b","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1698],[1886,1698],[1886,1752],[225,1752]],"region":{"top_left_x":225,"top_left_y":1697,"width":1661,"height":56},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"726f6331152c4a289770d0a9f1f75453","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1754],[1886,1754],[1886,1798],[225,1798]],"region":{"top_left_x":225,"top_left_y":1754,"width":1661,"height":44},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e883245070f4fce93d3076460f4741c","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1798],[1886,1798],[1886,1852],[225,1852]],"region":{"top_left_x":225,"top_left_y":1797,"width":1661,"height":55},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c87cbf754854097a8ecc7dbcece3ba8","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1858],[1886,1858],[1886,1904],[225,1904]],"region":{"top_left_x":225,"top_left_y":1858,"width":1661,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e15708e56624dd384e7d0a4de101635","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1902],[1886,1902],[1886,1953],[225,1953]],"region":{"top_left_x":225,"top_left_y":1901,"width":1661,"height":53},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0328545a88684bfda15e8cf3b826050f","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,1953],[1886,1953],[1886,2003],[225,2003]],"region":{"top_left_x":225,"top_left_y":1953,"width":1661,"height":51},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2c852bdbf5b4691a3cb71ed22981d38","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,2014],[1886,2014],[1886,2057],[225,2057]],"region":{"top_left_x":225,"top_left_y":2014,"width":1661,"height":44},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e47db6ba3bf8401181b2ec0941431e4e","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,2057],[1886,2057],[1886,2109],[225,2109]],"region":{"top_left_x":225,"top_left_y":2057,"width":1661,"height":53},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce31bff7369342558c7c7d6420fc1029","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,2109],[1886,2109],[1886,2161],[225,2161]],"region":{"top_left_x":225,"top_left_y":2109,"width":1661,"height":53},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6448d4aef2534dcdbbe1871665dbb9e7","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,2166],[1886,2166],[1886,2209],[225,2209]],"region":{"top_left_x":225,"top_left_y":2165,"width":1661,"height":45},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"feeea209e1544be28e4c25d09e4903e5","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,2211],[1886,2211],[1886,2263],[225,2263]],"region":{"top_left_x":225,"top_left_y":2211,"width":1661,"height":53},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"335037e6b8c54f8c88d3c4d12e4f2183","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,2263],[1886,2263],[1886,2315],[225,2315]],"region":{"top_left_x":225,"top_left_y":2263,"width":1661,"height":53},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c298007771ce4786b26c3b283f3a850e","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,2313],[1886,2313],[1886,2367],[225,2367]],"region":{"top_left_x":225,"top_left_y":2312,"width":1661,"height":56},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"265ba5d2c1854c0ea98341f980417c6c","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[225,2369],[1886,2369],[1886,2421],[225,2421]],"region":{"top_left_x":225,"top_left_y":2369,"width":1661,"height":53},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7941c3bae65c48a283a25bb4a97d3284","type":"table_row","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"","text_display":""},{"cnt":[[242,420],[725,420],[725,522],[242,522]],"region":{"top_left_x":242,"top_left_y":420,"width":484,"height":103},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b3366b28ad24ea9827551ffbf78cb45","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["39901028ae0e4883a54eb47c064c2ee0"],"text":"","text_display":"Visit","cell_row":0,"cell_column":0,"cell_row_span":2,"cell_col_span":1},{"cnt":[[247,442],[325,442],[325,474],[247,474]],"region":{"top_left_x":246,"top_left_y":441,"width":79,"height":34},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39901028ae0e4883a54eb47c064c2ee0","type":"simple_cell","conversion_output":false,"parent_id":"5b3366b28ad24ea9827551ffbf78cb45","text":"Visit","text_display":"Visit","cell_row":0,"cell_column":0,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[766,425],[950,425],[950,470],[766,470]],"region":{"top_left_x":766,"top_left_y":424,"width":185,"height":47},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fd62e05ac8947a086b5c522a09a1b3c","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["8aca25f1aa2a4f77aaeebb74c1465817"],"text":"","text_display":"Screening \\({ }^{(1)}\\)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":2},{"cnt":[[771,425],[950,425],[950,470],[771,470]],"region":{"top_left_x":770,"top_left_y":424,"width":181,"height":47},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8aca25f1aa2a4f77aaeebb74c1465817","type":"simple_cell","conversion_output":false,"parent_id":"1fd62e05ac8947a086b5c522a09a1b3c","text":"Screening \\({ }^{(1)}\\)","text_display":"Screening \\({ }^{(1)}\\)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":2,"confidence":0.7301120758056641,"confidence_rate":0.9869789656521},{"cnt":[[987,429],[1128,429],[1128,466],[987,466]],"region":{"top_left_x":987,"top_left_y":428,"width":142,"height":38},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8bc2443c871405a98eca9183f808dff","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["824065148a97427c9c939c8d995496cc"],"text":"","text_display":"Baseline","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":2},{"cnt":[[989,433],[1119,433],[1119,466],[989,466]],"region":{"top_left_x":989,"top_left_y":433,"width":131,"height":33},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"824065148a97427c9c939c8d995496cc","type":"simple_cell","conversion_output":false,"parent_id":"d8bc2443c871405a98eca9183f808dff","text":"Baseline","text_display":"Baseline","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":2,"confidence":1,"confidence_rate":1},{"cnt":[[1154,425],[1206,425],[1206,522],[1154,522]],"region":{"top_left_x":1153,"top_left_y":424,"width":53,"height":99},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6da17cf86e7d41c79af28cd9ae36b960","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["bc59b26f8a1f428fb7eac81d4940f36b"],"text":"","text_display":"V3","cell_row":0,"cell_column":5,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1152,451],[1204,451],[1204,494],[1152,494]],"region":{"top_left_x":1151,"top_left_y":450,"width":53,"height":44},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc59b26f8a1f428fb7eac81d4940f36b","type":"simple_cell","conversion_output":false,"parent_id":"6da17cf86e7d41c79af28cd9ae36b960","text":"V3","text_display":"V3","cell_row":0,"cell_column":5,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1230,425],[1284,425],[1284,524],[1230,524]],"region":{"top_left_x":1229,"top_left_y":424,"width":55,"height":101},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"782a1453215c4e88bcd3a5e4083b8f96","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["ac926a7995f44edea21eeeef505f9b4c"],"text":"","text_display":"V4","cell_row":0,"cell_column":6,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1234,451],[1282,451],[1282,494],[1234,494]],"region":{"top_left_x":1234,"top_left_y":450,"width":48,"height":44},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac926a7995f44edea21eeeef505f9b4c","type":"simple_cell","conversion_output":false,"parent_id":"782a1453215c4e88bcd3a5e4083b8f96","text":"V4","text_display":"V4","cell_row":0,"cell_column":6,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1310,425],[1362,425],[1362,524],[1310,524]],"region":{"top_left_x":1309,"top_left_y":424,"width":53,"height":101},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"671c1f1922954ce6ab2adde88e5d517b","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["3b85cda8d2c44bbfb80b0736f54ca5e8"],"text":"","text_display":"V5","cell_row":0,"cell_column":7,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1310,451],[1362,451],[1362,494],[1310,494]],"region":{"top_left_x":1309,"top_left_y":450,"width":53,"height":44},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b85cda8d2c44bbfb80b0736f54ca5e8","type":"simple_cell","conversion_output":false,"parent_id":"671c1f1922954ce6ab2adde88e5d517b","text":"V5","text_display":"V5","cell_row":0,"cell_column":7,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1388,425],[1440,425],[1440,524],[1388,524]],"region":{"top_left_x":1387,"top_left_y":424,"width":53,"height":101},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"719ff35d007849518d4c0a4c5f48911f","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["158cb9ecbe2240b2b30b2da6163b3c62"],"text":"","text_display":"V6","cell_row":0,"cell_column":8,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1392,451],[1438,451],[1438,494],[1392,494]],"region":{"top_left_x":1392,"top_left_y":450,"width":46,"height":44},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"158cb9ecbe2240b2b30b2da6163b3c62","type":"simple_cell","conversion_output":false,"parent_id":"719ff35d007849518d4c0a4c5f48911f","text":"V6","text_display":"V6","cell_row":0,"cell_column":8,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1468,425],[1518,425],[1518,526],[1468,526]],"region":{"top_left_x":1467,"top_left_y":424,"width":51,"height":103},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"efd2cb5df4844116bd0f4cfe06deee90","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["858d212753ed4aceab26bdcbe0101c72"],"text":"","text_display":"V7","cell_row":0,"cell_column":9,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1468,451],[1518,451],[1518,494],[1468,494]],"region":{"top_left_x":1467,"top_left_y":450,"width":51,"height":44},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"858d212753ed4aceab26bdcbe0101c72","type":"simple_cell","conversion_output":false,"parent_id":"efd2cb5df4844116bd0f4cfe06deee90","text":"V7","text_display":"V7","cell_row":0,"cell_column":9,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1546,425],[1596,425],[1596,522],[1546,522]],"region":{"top_left_x":1545,"top_left_y":424,"width":51,"height":99},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11053cfea3244fd7a85bd182779404e7","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["9a2783d2c6b143bfbee51943d51ad62e"],"text":"","text_display":"V8","cell_row":0,"cell_column":10,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1550,451],[1594,451],[1594,494],[1550,494]],"region":{"top_left_x":1550,"top_left_y":450,"width":44,"height":44},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a2783d2c6b143bfbee51943d51ad62e","type":"simple_cell","conversion_output":false,"parent_id":"11053cfea3244fd7a85bd182779404e7","text":"V8","text_display":"V8","cell_row":0,"cell_column":10,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1622,425],[1674,425],[1674,524],[1622,524]],"region":{"top_left_x":1621,"top_left_y":424,"width":53,"height":101},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a355345060ad4bfb8636d40c846eaa8a","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["4715769d8180408b8530d35d285b8fe2"],"text":"","text_display":"V9","cell_row":0,"cell_column":11,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1624,451],[1676,451],[1676,494],[1624,494]],"region":{"top_left_x":1623,"top_left_y":450,"width":53,"height":44},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4715769d8180408b8530d35d285b8fe2","type":"simple_cell","conversion_output":false,"parent_id":"a355345060ad4bfb8636d40c846eaa8a","text":"V9","text_display":"V9","cell_row":0,"cell_column":11,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1700,425],[1769,425],[1769,522],[1700,522]],"region":{"top_left_x":1699,"top_left_y":424,"width":70,"height":99},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"163523b0502049e395e77cf6d1c1b310","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["2358e7200a734b68be952f1b1c785cde"],"text":"","text_display":"V10","cell_row":0,"cell_column":12,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1706,459],[1767,459],[1767,494],[1706,494]],"region":{"top_left_x":1706,"top_left_y":459,"width":61,"height":35},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2358e7200a734b68be952f1b1c785cde","type":"simple_cell","conversion_output":false,"parent_id":"163523b0502049e395e77cf6d1c1b310","text":"V10","text_display":"V10","cell_row":0,"cell_column":12,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1792,522],[1796,423],[1863,425],[1860,524]],"region":{"top_left_x":1792,"top_left_y":422,"width":71,"height":103},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b54a3e9b41254b19ab87bba79a2c9115","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["31d17c721a0448bd8768c975b7cd3791"],"text":"","text_display":"V11","cell_row":0,"cell_column":13,"cell_row_span":2,"cell_col_span":1},{"cnt":[[1797,459],[1858,459],[1858,494],[1797,494]],"region":{"top_left_x":1797,"top_left_y":459,"width":61,"height":35},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31d17c721a0448bd8768c975b7cd3791","type":"simple_cell","conversion_output":false,"parent_id":"b54a3e9b41254b19ab87bba79a2c9115","text":"V11","text_display":"V11","cell_row":0,"cell_column":13,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[775,485],[836,485],[836,520],[775,520]],"region":{"top_left_x":775,"top_left_y":485,"width":61,"height":35},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64beefa5f12d4980a62439eaa718a319","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"V1a","text_display":"V1a","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[883,485],[948,485],[948,518],[883,518]],"region":{"top_left_x":883,"top_left_y":485,"width":66,"height":33},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1114b62bf844fddb65f653ad8f2ab7f","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"V1b","text_display":"V1b","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1028,485],[1080,485],[1080,516],[1028,516]],"region":{"top_left_x":1028,"top_left_y":485,"width":53,"height":31},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62e8ae94becb4b63bf2d4c12a4ddd8df","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"V2","text_display":"V2","cell_row":1,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,533],[359,533],[359,574],[247,574]],"region":{"top_left_x":246,"top_left_y":532,"width":114,"height":43},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d454235405a74203a26e00ac3a6910e3","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Week \\({ }^{ ( 2 ) }\\)","text_display":"Week \\({ }^{ ( 2 ) }\\)","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9475200176239014,"confidence_rate":0.9980765944244863},{"cnt":[[766,529],[955,529],[955,613],[766,613]],"region":{"top_left_x":766,"top_left_y":528,"width":189,"height":86},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7a8c0fb8b2140c8a6f901518d14d791","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["b33dfbaa6a454e55845c79b9ca14a3fd"],"text":"","text_display":"-42 to -4 days","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":2},{"cnt":[[797,533],[924,533],[924,609],[797,609]],"region":{"top_left_x":796,"top_left_y":532,"width":129,"height":77},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b33dfbaa6a454e55845c79b9ca14a3fd","type":"complex_cell","conversion_output":false,"parent_id":"a7a8c0fb8b2140c8a6f901518d14d791","children_ids":["10911d37d08f40b6a8283dee0de9a77e","6be79b47894e42a8b17dffa2f60ad61c"],"text":"-42 to -4 days","text_display":"-42 to -4 days","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":2,"confidence":1,"confidence_rate":1},{"cnt":[[797,537],[924,537],[924,570],[797,570]],"region":{"top_left_x":796,"top_left_y":537,"width":129,"height":33},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10911d37d08f40b6a8283dee0de9a77e","type":"text","conversion_output":false,"parent_id":"b33dfbaa6a454e55845c79b9ca14a3fd","text":"-42 to -4","text_display":"-42 to -4","confidence":1,"confidence_rate":1},{"cnt":[[823,572],[898,572],[898,611],[823,611]],"region":{"top_left_x":822,"top_left_y":571,"width":77,"height":40},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6be79b47894e42a8b17dffa2f60ad61c","type":"text","conversion_output":false,"parent_id":"b33dfbaa6a454e55845c79b9ca14a3fd","text":"days","text_display":" days","confidence":1,"confidence_rate":1},{"cnt":[[983,529],[1128,529],[1128,613],[983,613]],"region":{"top_left_x":982,"top_left_y":528,"width":147,"height":86},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d5c5c8a6d3c479c8169184de7032a47","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["374cf721b86641c989f61e2b862a417c"],"text":"","text_display":"\\(0^{(3)}\\)","cell_row":2,"cell_column":3,"cell_row_span":1,"cell_col_span":2},{"cnt":[[1031,546],[1083,546],[1083,589],[1031,589]],"region":{"top_left_x":1030,"top_left_y":545,"width":53,"height":45},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"374cf721b86641c989f61e2b862a417c","type":"simple_cell","conversion_output":false,"parent_id":"1d5c5c8a6d3c479c8169184de7032a47","text":"\\(0^{(3)}\\)","text_display":"\\(0^{(3)}\\)","cell_row":2,"cell_column":3,"cell_row_span":1,"cell_col_span":2,"confidence":0.5470054806210101,"confidence_rate":0.9466317391193187},{"cnt":[[1169,539],[1191,539],[1191,589],[1169,589]],"region":{"top_left_x":1169,"top_left_y":539,"width":22,"height":51},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28a274a225024f919a2bc1714c0eaa31","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"1","text_display":"1","cell_row":2,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1247,555],[1273,555],[1273,589],[1247,589]],"region":{"top_left_x":1247,"top_left_y":554,"width":27,"height":36},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81ce0c17c8614dc988dda48414dfb2dd","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"2","text_display":"2","cell_row":2,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1325,555],[1349,555],[1349,589],[1325,589]],"region":{"top_left_x":1325,"top_left_y":554,"width":24,"height":36},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a97c48a605ca4f848335c9e35d3ab76f","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"3","text_display":"3","cell_row":2,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1394,555],[1438,555],[1438,589],[1394,589]],"region":{"top_left_x":1394,"top_left_y":554,"width":44,"height":36},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ca69c5c55a74b7995e3d90550a5ebe3","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"12","text_display":"12","cell_row":2,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1472,555],[1518,555],[1518,589],[1472,589]],"region":{"top_left_x":1472,"top_left_y":554,"width":46,"height":36},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17d2d4ad190b463e88004a442428827f","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"26","text_display":"26","cell_row":2,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1550,555],[1594,555],[1594,589],[1550,589]],"region":{"top_left_x":1550,"top_left_y":554,"width":44,"height":36},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4d9f2f2e7f84173bfe55c4c31c205d4","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"27","text_display":"27","cell_row":2,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1628,555],[1676,555],[1676,589],[1628,589]],"region":{"top_left_x":1628,"top_left_y":554,"width":48,"height":36},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b57a877a614840659e64eb0a6712f8b6","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"28","text_display":"28","cell_row":2,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1715,555],[1762,555],[1762,589],[1715,589]],"region":{"top_left_x":1714,"top_left_y":554,"width":49,"height":36},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e44e73be610d4e62a7b84ada6cfe9402","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"29","text_display":"29","cell_row":2,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1810,555],[1851,555],[1851,589],[1810,589]],"region":{"top_left_x":1810,"top_left_y":554,"width":42,"height":36},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24bbe9611471469f9326d422be190244","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"38","text_display":"38","cell_row":2,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,617],[543,617],[543,656],[247,656]],"region":{"top_left_x":246,"top_left_y":617,"width":298,"height":40},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abcd3f884767417591cb1b215ac4f987","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Informed consents \\({ }^{(4)}\\)","text_display":"Informed consents \\({ }^{(4)}\\)","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[784,624],[823,624],[823,659],[784,659]],"region":{"top_left_x":783,"top_left_y":623,"width":40,"height":36},"line":105,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1e58dab26c14ebba27b464e86fb70f8","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,676],[452,676],[452,713],[247,713]],"region":{"top_left_x":246,"top_left_y":675,"width":207,"height":38},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"268dd220038542edb2fab7bff4ca57bb","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Demographics","text_display":"Demographics","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[784,676],[823,676],[823,711],[784,711]],"region":{"top_left_x":783,"top_left_y":675,"width":40,"height":36},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5392abdb4edc471d994da1ab96ce7ca6","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,728],[621,728],[621,765],[247,765]],"region":{"top_left_x":246,"top_left_y":727,"width":376,"height":38},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd758511eb2e4a53a8a7693262644f04","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Medical/medication history","text_display":"Medical/medication history","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[784,728],[823,728],[823,762],[784,762]],"region":{"top_left_x":783,"top_left_y":727,"width":40,"height":36},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7bba678b9aa44ce93782d480f962244","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,780],[621,780],[621,812],[247,812]],"region":{"top_left_x":246,"top_left_y":779,"width":376,"height":34},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0c040b059ba409db1e103fcc101c885","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Inclusion/Exclusion criteria","text_display":"Inclusion/Exclusion criteria","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[784,780],[823,780],[823,814],[784,814]],"region":{"top_left_x":783,"top_left_y":779,"width":40,"height":36},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe1d26cc25b0426ab66753e1a65fe5e8","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[901,780],[931,780],[931,814],[901,814]],"region":{"top_left_x":900,"top_left_y":779,"width":31,"height":36},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f6c57e960954b09932636ff0361afb8","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":6,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[996,780],[1033,780],[1033,814],[996,814]],"region":{"top_left_x":995,"top_left_y":779,"width":38,"height":36},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ae9972fd7d3488db0f0a68be1dce438","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":6,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,823],[721,823],[721,869],[247,869]],"region":{"top_left_x":246,"top_left_y":823,"width":475,"height":46},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"969bd24f2ace431da9a6d700ebb0af6d","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Withdraw analgesia prior to visit \\({ }^{(5)}\\)","text_display":"Withdraw analgesia prior to visit \\({ }^{(5)}\\)","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9999796452144983},{"cnt":[[901,832],[931,832],[931,866],[901,866]],"region":{"top_left_x":900,"top_left_y":831,"width":31,"height":36},"line":115,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e330b8ec0764a1c818c2e718b21d6ec","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":7,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[996,832],[1033,832],[1033,866],[996,866]],"region":{"top_left_x":995,"top_left_y":831,"width":38,"height":36},"line":116,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27f4d8661ea64367892f1e7aa917c538","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":7,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1397,832],[1431,832],[1431,866],[1397,866]],"region":{"top_left_x":1396,"top_left_y":831,"width":36,"height":36},"line":117,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3af5c4976a994942a23ffba314b6df6b","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":7,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1481,832],[1518,832],[1518,866],[1481,866]],"region":{"top_left_x":1480,"top_left_y":831,"width":38,"height":36},"line":118,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d6679a7745948d98a5cd926936f3504","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":7,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1814,832],[1851,832],[1851,866],[1814,866]],"region":{"top_left_x":1814,"top_left_y":831,"width":38,"height":36},"line":119,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"007dde4178d24f28b264f1db5a134c40","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":7,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,879],[630,879],[630,921],[247,921]],"region":{"top_left_x":246,"top_left_y":879,"width":384,"height":42},"line":120,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e9b1c0abb814fa999cd8001834e0136","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Identification of target knee","text_display":"Identification of target knee","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[901,884],[931,884],[931,916],[901,916]],"region":{"top_left_x":900,"top_left_y":883,"width":31,"height":34},"line":121,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d63b0059f8f64244976142cd3b9747a1","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":8,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,931],[461,931],[461,966],[247,966]],"region":{"top_left_x":246,"top_left_y":931,"width":216,"height":36},"line":122,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c81831bbbfd24d80bcfbd8ad18dd8e24","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Randomization","text_display":"Randomization","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,923],[1117,923],[1117,968],[1083,968]],"region":{"top_left_x":1082,"top_left_y":922,"width":36,"height":47},"line":123,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"422ef98951a748b6853566e0981dc142","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":9,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":0.91259765625,"confidence_rate":0.9848722288601055},{"cnt":[[247,983],[617,983],[617,1025],[247,1025]],"region":{"top_left_x":246,"top_left_y":983,"width":371,"height":42},"line":124,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"527ac93a39bf4656b1669a3723c57994","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"WOMAC (question 1 only)","text_display":"WOMAC (question 1 only)","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[784,975],[823,975],[823,1018],[784,1018]],"region":{"top_left_x":783,"top_left_y":974,"width":40,"height":45},"line":125,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6585cd051c054731b694d10028eeee33","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99658203125,"confidence_rate":0.999429525557531},{"cnt":[[901,975],[931,975],[931,1020],[901,1020]],"region":{"top_left_x":900,"top_left_y":974,"width":31,"height":47},"line":126,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87e5c50e30764a56a366920d531ce997","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":10,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.99169921875,"confidence_rate":0.9986117271137709},{"cnt":[[247,1035],[643,1035],[643,1076],[247,1076]],"region":{"top_left_x":246,"top_left_y":1035,"width":397,"height":42},"line":127,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43b019f2c5744a56957cd00445cd8ccd","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"WOMAC (full questionnaire)","text_display":"WOMAC (full questionnaire)","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[996,1027],[1035,1027],[1035,1072],[996,1072]],"region":{"top_left_x":995,"top_left_y":1026,"width":40,"height":47},"line":128,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5d964d23a1b446cbc808b57b35a845e","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":11,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9998371733163992},{"cnt":[[1397,1027],[1433,1027],[1433,1070],[1397,1070]],"region":{"top_left_x":1396,"top_left_y":1026,"width":38,"height":44},"line":129,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7aa40ec0501545b1ad6f0b6a84c852e7","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":11,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9998371733163992},{"cnt":[[1481,1027],[1518,1027],[1518,1070],[1481,1070]],"region":{"top_left_x":1480,"top_left_y":1026,"width":38,"height":44},"line":130,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f67d9a85f5454af49af453064822c442","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"x","text_display":"x","cell_row":11,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":0.5,"confidence_rate":0.8908987181403393},{"cnt":[[1814,1027],[1851,1027],[1851,1070],[1814,1070]],"region":{"top_left_x":1814,"top_left_y":1026,"width":38,"height":44},"line":131,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4b5ddfbdfe6434a8d4a34322166bbce","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":11,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":0.943359375,"confidence_rate":0.9903290718950725},{"cnt":[[247,1087],[652,1087],[652,1122],[247,1122]],"region":{"top_left_x":246,"top_left_y":1087,"width":406,"height":35},"line":132,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3fe3d9362fb4a17b4f815a73fe6504a","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Patient's Global Assessment","text_display":"Patient's Global Assessment","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[784,1081],[823,1081],[823,1122],[784,1122]],"region":{"top_left_x":783,"top_left_y":1080,"width":40,"height":42},"line":133,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c0986d9edbb4b35988418372aba423b","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[994,1081],[1035,1081],[1035,1122],[994,1122]],"region":{"top_left_x":993,"top_left_y":1080,"width":42,"height":42},"line":134,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39d925033d2d497daa2824a9a7951a3d","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":12,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[1397,1081],[1433,1081],[1433,1122],[1397,1122]],"region":{"top_left_x":1396,"top_left_y":1080,"width":38,"height":42},"line":135,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91d24f4472fb445c90d543753ff3ad14","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":12,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9998371733163992},{"cnt":[[1477,1081],[1518,1081],[1518,1122],[1477,1122]],"region":{"top_left_x":1476,"top_left_y":1080,"width":42,"height":42},"line":136,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98ce482b24074a05b3e2fe62675e11e0","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":12,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":0.958984375,"confidence_rate":0.9930442213229864},{"cnt":[[1814,1081],[1851,1081],[1851,1122],[1814,1122]],"region":{"top_left_x":1814,"top_left_y":1080,"width":38,"height":42},"line":137,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"399a5a274bde474b83776fd70701736c","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":12,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":0.921875,"confidence_rate":0.9865338838419667},{"cnt":[[247,1139],[704,1139],[704,1176],[247,1176]],"region":{"top_left_x":246,"top_left_y":1139,"width":458,"height":38},"line":138,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ab0cd5d0668465f85b92d6973586f3a","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"KOOS QOL and Symptom Index","text_display":"KOOS QOL and Symptom Index","cell_row":13,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[996,1133],[1035,1133],[1035,1174],[996,1174]],"region":{"top_left_x":995,"top_left_y":1132,"width":40,"height":42},"line":139,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"351c10e406d94245b10431c76d5ab0d7","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":13,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1397,1133],[1433,1133],[1433,1174],[1397,1174]],"region":{"top_left_x":1396,"top_left_y":1132,"width":38,"height":42},"line":140,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b1dfa8cf6fb42be8a1db47158c9a3a8","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":13,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,1133],[1518,1133],[1518,1174],[1477,1174]],"region":{"top_left_x":1476,"top_left_y":1132,"width":42,"height":42},"line":141,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1599beadcfd4f94a6dceb9943908ebd","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":13,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[1814,1133],[1851,1133],[1851,1174],[1814,1174]],"region":{"top_left_x":1814,"top_left_y":1132,"width":38,"height":42},"line":142,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b6b74c71ff54a1285e71f2a87c1a2e3","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":13,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9997557102298569},{"cnt":[[247,1191],[333,1191],[333,1226],[247,1226]],"region":{"top_left_x":246,"top_left_y":1191,"width":88,"height":35},"line":143,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e6b6e4193e9439aac056827b71dbef4","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"PGIC","text_display":"PGIC","cell_row":14,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1397,1185],[1433,1185],[1433,1226],[1397,1226]],"region":{"top_left_x":1396,"top_left_y":1184,"width":38,"height":42},"line":144,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9eee232312b54663aa66200ab185bf84","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":14,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,1185],[1518,1185],[1518,1226],[1477,1226]],"region":{"top_left_x":1476,"top_left_y":1184,"width":42,"height":42},"line":145,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99adb8246af543cca7af0927a5df204c","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":14,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9998371733163992},{"cnt":[[1814,1185],[1851,1185],[1851,1226],[1814,1226]],"region":{"top_left_x":1814,"top_left_y":1184,"width":38,"height":42},"line":146,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89ec18e8c0154ed68f82652be8cae9fa","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":14,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1243],[552,1243],[552,1276],[247,1276]],"region":{"top_left_x":246,"top_left_y":1243,"width":306,"height":33},"line":147,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2d40224958b4b638d12a69640c0df7b","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Pain NRS both knees","text_display":"Pain NRS both knees","cell_row":15,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[784,1237],[823,1237],[823,1278],[784,1278]],"region":{"top_left_x":783,"top_left_y":1236,"width":40,"height":42},"line":148,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d58f2f3c64694a31b349d9590cedb8e9","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":15,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[890,1237],[931,1237],[931,1278],[890,1278]],"region":{"top_left_x":889,"top_left_y":1236,"width":42,"height":42},"line":149,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a838777e48504738959f20d81e247f13","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":15,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[996,1237],[1035,1237],[1035,1278],[996,1278]],"region":{"top_left_x":995,"top_left_y":1236,"width":40,"height":42},"line":150,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13bd9a4e12114263bdb4bf605b746324","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":15,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[1397,1237],[1433,1237],[1433,1278],[1397,1278]],"region":{"top_left_x":1396,"top_left_y":1236,"width":38,"height":42},"line":151,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"802bdcd0c81b4e2eb7227b6b812079d8","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":15,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,1237],[1518,1237],[1518,1278],[1477,1278]],"region":{"top_left_x":1476,"top_left_y":1236,"width":42,"height":42},"line":152,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e88b0ec112ee457f83aa8c018e19809b","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":15,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[1814,1237],[1851,1237],[1851,1278],[1814,1278]],"region":{"top_left_x":1814,"top_left_y":1236,"width":38,"height":42},"line":153,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cc371411f3b4f4bb79480d9894cf395","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":15,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1295],[509,1295],[509,1332],[247,1332]],"region":{"top_left_x":246,"top_left_y":1295,"width":263,"height":38},"line":154,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98c1edae898143d8bdfa741a20b2b2b5","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Pain in other joints","text_display":"Pain in other joints","cell_row":16,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[994,1289],[1035,1289],[1035,1330],[994,1330]],"region":{"top_left_x":993,"top_left_y":1288,"width":42,"height":42},"line":155,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28b5901228534370a49623eaad850786","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":16,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[1477,1289],[1518,1289],[1518,1330],[1477,1330]],"region":{"top_left_x":1476,"top_left_y":1288,"width":42,"height":42},"line":156,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"312bfc565b43443d8f2ffe4f7fd5cd22","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":16,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[247,1347],[418,1347],[418,1380],[247,1380]],"region":{"top_left_x":246,"top_left_y":1347,"width":172,"height":33},"line":157,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c97bb72fa384ec78b5e669463cd1ec2","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"MOS SF-36","text_display":"MOS SF-36","cell_row":17,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[994,1341],[1035,1341],[1035,1382],[994,1382]],"region":{"top_left_x":993,"top_left_y":1340,"width":42,"height":42},"line":158,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3adc17e3fc3f423dbe50e5be8f55d1f6","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":17,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,1341],[1518,1341],[1518,1382],[1477,1382]],"region":{"top_left_x":1476,"top_left_y":1340,"width":42,"height":42},"line":159,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"322f4d87d1ec4f2bbc6c152b9064d50b","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":17,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1399],[348,1399],[348,1429],[247,1429]],"region":{"top_left_x":246,"top_left_y":1399,"width":103,"height":31},"line":160,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b46c01a14b074367a351c8067e5dc57d","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"ICOAP","text_display":"ICOAP","cell_row":18,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[996,1393],[1035,1393],[1035,1434],[996,1434]],"region":{"top_left_x":995,"top_left_y":1392,"width":40,"height":42},"line":161,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64c9753192784fcd9a6b5bddec4c0998","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":18,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1397,1393],[1433,1393],[1433,1434],[1397,1434]],"region":{"top_left_x":1396,"top_left_y":1392,"width":38,"height":42},"line":162,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb3a5ae88c70492784bea9bcc5ecc0db","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":18,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,1395],[1518,1395],[1518,1434],[1477,1434]],"region":{"top_left_x":1476,"top_left_y":1394,"width":42,"height":40},"line":163,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1880ffbf84934a138104e04a9ee000d6","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":18,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1814,1393],[1851,1393],[1851,1434],[1814,1434]],"region":{"top_left_x":1814,"top_left_y":1392,"width":38,"height":42},"line":164,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"726ed3d3e010409dabcec6c4c3bce7bc","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":18,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1451],[312,1451],[312,1481],[247,1481]],"region":{"top_left_x":246,"top_left_y":1451,"width":66,"height":31},"line":165,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"541dcfa58eaf46fd978ba5069353e2ee","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"AEs","text_display":"AEs","cell_row":19,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[764,1447],[1862,1447],[1862,1486],[764,1486]],"region":{"top_left_x":764,"top_left_y":1446,"width":1099,"height":40},"line":166,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aaef6a09514646d5aae7309b7c069d7d","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["cc1687fa9180418f935eae04c845769b"],"text":"","text_display":"Continuous","cell_row":19,"cell_column":1,"cell_row_span":1,"cell_col_span":13},{"cnt":[[1230,1451],[1397,1451],[1397,1484],[1230,1484]],"region":{"top_left_x":1229,"top_left_y":1451,"width":168,"height":33},"line":167,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc1687fa9180418f935eae04c845769b","type":"simple_cell","conversion_output":false,"parent_id":"aaef6a09514646d5aae7309b7c069d7d","text":"Continuous","text_display":"Continuous","cell_row":19,"cell_column":1,"cell_row_span":1,"cell_col_span":13,"confidence":1,"confidence_rate":1},{"cnt":[[247,1501],[604,1501],[604,1533],[247,1533]],"region":{"top_left_x":246,"top_left_y":1500,"width":358,"height":34},"line":168,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"feb178abc8b64b22813d8cff6a9298dc","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Concomitant medications","text_display":"Concomitant medications","cell_row":20,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[764,1499],[1860,1499],[1860,1538],[764,1538]],"region":{"top_left_x":764,"top_left_y":1498,"width":1096,"height":40},"line":169,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49e497e982e047a5a3daf01f008b38b6","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["ff4e33ce6f444377aa61f5bc5a6cbc78"],"text":"","text_display":"Continuous","cell_row":20,"cell_column":1,"cell_row_span":1,"cell_col_span":13},{"cnt":[[1230,1503],[1397,1503],[1397,1536],[1230,1536]],"region":{"top_left_x":1229,"top_left_y":1503,"width":168,"height":33},"line":170,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff4e33ce6f444377aa61f5bc5a6cbc78","type":"simple_cell","conversion_output":false,"parent_id":"49e497e982e047a5a3daf01f008b38b6","text":"Continuous","text_display":"Continuous","cell_row":20,"cell_column":1,"cell_row_span":1,"cell_col_span":13,"confidence":1,"confidence_rate":1},{"cnt":[[247,1553],[717,1553],[717,1592],[247,1592]],"region":{"top_left_x":246,"top_left_y":1552,"width":471,"height":40},"line":171,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ade3121ffbf24bcc9b0b0d4000bf376a","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Surgical procedures (target knee)","text_display":"Surgical procedures (target knee)","cell_row":21,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[764,1551],[1864,1551],[1864,1596],[764,1596]],"region":{"top_left_x":764,"top_left_y":1550,"width":1101,"height":47},"line":172,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62aee2fc31e9439f9b66f208b4a63f02","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["e9dadbec146e4adcbd8991990fc7f19e"],"text":"","text_display":"Continuous","cell_row":21,"cell_column":1,"cell_row_span":1,"cell_col_span":13},{"cnt":[[1230,1555],[1397,1555],[1397,1588],[1230,1588]],"region":{"top_left_x":1229,"top_left_y":1555,"width":168,"height":33},"line":173,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9dadbec146e4adcbd8991990fc7f19e","type":"simple_cell","conversion_output":false,"parent_id":"62aee2fc31e9439f9b66f208b4a63f02","text":"Continuous","text_display":"Continuous","cell_row":21,"cell_column":1,"cell_row_span":1,"cell_col_span":13,"confidence":1,"confidence_rate":1},{"cnt":[[247,1603],[600,1603],[600,1642],[247,1642]],"region":{"top_left_x":246,"top_left_y":1602,"width":354,"height":40},"line":174,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62813d4892b74561b8da62af8025d00d","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Review of subject diaries","text_display":"Review of subject diaries","cell_row":22,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[890,1603],[931,1603],[931,1640],[890,1640]],"region":{"top_left_x":889,"top_left_y":1602,"width":42,"height":38},"line":175,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2811eedf553d45b292e12b53d0f06d6e","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[996,1603],[1033,1603],[1033,1640],[996,1640]],"region":{"top_left_x":995,"top_left_y":1602,"width":38,"height":38},"line":176,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7464905a9fe471480754e414a5a422d","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,1603],[1117,1603],[1117,1637],[1083,1637]],"region":{"top_left_x":1082,"top_left_y":1602,"width":36,"height":36},"line":177,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ab15f3be6f24da3a22de53d29dea454","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1165,1603],[1195,1603],[1195,1637],[1165,1637]],"region":{"top_left_x":1164,"top_left_y":1602,"width":32,"height":36},"line":178,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d11debdbcf7a4188af4f5b9a6f47961b","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1241,1603],[1273,1603],[1273,1637],[1241,1637]],"region":{"top_left_x":1240,"top_left_y":1602,"width":34,"height":36},"line":179,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01273652d4bd49d49dd08bc4fd01acf5","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1323,1603],[1351,1603],[1351,1637],[1323,1637]],"region":{"top_left_x":1322,"top_left_y":1602,"width":30,"height":36},"line":180,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75f6e7e998b84342a92554065676b89f","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1397,1603],[1431,1603],[1431,1637],[1397,1637]],"region":{"top_left_x":1396,"top_left_y":1602,"width":36,"height":36},"line":181,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bee93502c94a42988e1c973c8976acdc","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1481,1603],[1507,1603],[1507,1637],[1481,1637]],"region":{"top_left_x":1480,"top_left_y":1602,"width":27,"height":36},"line":182,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff66e1d6668e476491b96bab4b543e49","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1555,1603],[1589,1603],[1589,1637],[1555,1637]],"region":{"top_left_x":1554,"top_left_y":1602,"width":36,"height":36},"line":183,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc4513e8b30f4fc7be83a35136c43aa5","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1637,1603],[1676,1603],[1676,1637],[1637,1637]],"region":{"top_left_x":1636,"top_left_y":1602,"width":40,"height":36},"line":184,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54bafeeae7834b028eaf12f8121b818d","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[1719,1603],[1762,1603],[1762,1637],[1719,1637]],"region":{"top_left_x":1719,"top_left_y":1602,"width":44,"height":36},"line":185,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d317d33f93246dea3b877c62de59157","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1814,1603],[1851,1603],[1851,1637],[1814,1637]],"region":{"top_left_x":1814,"top_left_y":1602,"width":38,"height":36},"line":186,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed8d8dca52e64b3998a75103d17694d6","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":22,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1646],[431,1646],[431,1694],[247,1694]],"region":{"top_left_x":246,"top_left_y":1645,"width":185,"height":49},"line":187,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58b41f330aed46698e9a943b26065861","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Vital signs \\({ }^{(6)}\\)","text_display":"Vital signs \\({ }^{(6)}\\)","cell_row":23,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99755859375,"confidence_rate":0.9999059893676697},{"cnt":[[890,1655],[931,1655],[931,1689],[890,1689]],"region":{"top_left_x":889,"top_left_y":1654,"width":42,"height":36},"line":188,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73661f771a2d4d1b8b30ac6c2a3a0dd9","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,1655],[1117,1655],[1117,1689],[1083,1689]],"region":{"top_left_x":1082,"top_left_y":1654,"width":36,"height":36},"line":189,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81b46b265d5f4e838b8ca4f9b371a963","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1165,1655],[1195,1655],[1195,1689],[1165,1689]],"region":{"top_left_x":1164,"top_left_y":1654,"width":32,"height":36},"line":190,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6919e04a4a54e1d876f0c8db3507c32","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1241,1655],[1273,1655],[1273,1689],[1241,1689]],"region":{"top_left_x":1240,"top_left_y":1654,"width":34,"height":36},"line":191,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc40a3d60aeb406caf97316666260315","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1321,1655],[1351,1655],[1351,1689],[1321,1689]],"region":{"top_left_x":1320,"top_left_y":1654,"width":32,"height":36},"line":192,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d970ea9283a409b82e1ea0c2a4c59dc","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1397,1655],[1431,1655],[1431,1689],[1397,1689]],"region":{"top_left_x":1396,"top_left_y":1654,"width":36,"height":36},"line":193,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a68f2adc18c74cba9dd523299f01bd30","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1481,1655],[1518,1655],[1518,1689],[1481,1689]],"region":{"top_left_x":1480,"top_left_y":1654,"width":38,"height":36},"line":194,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46870aa0c8ea429c84d19232e69004ed","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1555,1655],[1589,1655],[1589,1689],[1555,1689]],"region":{"top_left_x":1554,"top_left_y":1654,"width":36,"height":36},"line":195,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"097979d70f7a4193a155924fd41c279b","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1637,1655],[1676,1655],[1676,1689],[1637,1689]],"region":{"top_left_x":1636,"top_left_y":1654,"width":40,"height":36},"line":196,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dc069d7a226459a884bc03b69899b8a","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1721,1655],[1762,1655],[1762,1689],[1721,1689]],"region":{"top_left_x":1721,"top_left_y":1654,"width":42,"height":36},"line":197,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"972ca00e21b5442d95ac4e81035d8178","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1814,1655],[1851,1655],[1851,1689],[1814,1689]],"region":{"top_left_x":1814,"top_left_y":1654,"width":38,"height":36},"line":198,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e2dd9d6abc1454ba2b3369f37422b05","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":23,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1700],[574,1700],[574,1743],[247,1743]],"region":{"top_left_x":246,"top_left_y":1700,"width":328,"height":44},"line":199,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a88964ccdd5247c0a472a2496e0a3232","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Physical examination \\({ }^{(7)}\\)","text_display":"Physical examination \\({ }^{(7)}\\)","cell_row":24,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[901,1707],[931,1707],[931,1741],[901,1741]],"region":{"top_left_x":900,"top_left_y":1706,"width":31,"height":36},"line":200,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c36d1a5f3a274e77916231e276df91c8","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":24,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1397,1709],[1431,1709],[1431,1741],[1397,1741]],"region":{"top_left_x":1396,"top_left_y":1708,"width":36,"height":34},"line":201,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e48c1f6d4c6b40f4a7bd3790d439b7ea","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":24,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1481,1707],[1518,1707],[1518,1741],[1481,1741]],"region":{"top_left_x":1480,"top_left_y":1706,"width":38,"height":36},"line":202,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ea101f033e34db09eaa6b1d6f6f46bb","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":24,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1759],[322,1759],[322,1793],[247,1793]],"region":{"top_left_x":246,"top_left_y":1758,"width":77,"height":36},"line":203,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b183c16230964b21a3c78cd50da3cbca","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"ECG","text_display":"ECG","cell_row":25,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[901,1759],[931,1759],[931,1795],[901,1795]],"region":{"top_left_x":900,"top_left_y":1758,"width":31,"height":38},"line":204,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"146931f8f5e24c7eb1280cdb163f7cdf","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":25,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1802],[695,1802],[695,1847],[247,1847]],"region":{"top_left_x":246,"top_left_y":1801,"width":449,"height":47},"line":205,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fb1999005d04193bcb5d4da5d886c99","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Clinical laboratory specimens \\({ }^{(8)}\\)","text_display":"Clinical laboratory specimens \\({ }^{(8)}\\)","cell_row":26,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[901,1811],[931,1811],[931,1847],[901,1847]],"region":{"top_left_x":900,"top_left_y":1810,"width":31,"height":38},"line":206,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e6036a6da23445eb89e98763586f0c4","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":26,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,1811],[1117,1811],[1117,1847],[1083,1847]],"region":{"top_left_x":1082,"top_left_y":1810,"width":36,"height":38},"line":207,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5153ea9570c5416999392a1e984c4d06","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":26,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1481,1811],[1518,1811],[1518,1847],[1481,1847]],"region":{"top_left_x":1480,"top_left_y":1810,"width":38,"height":38},"line":208,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53930665ce084989a645c5c410808866","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":26,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[247,1863],[695,1863],[695,1899],[247,1899]],"region":{"top_left_x":246,"top_left_y":1862,"width":449,"height":38},"line":209,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc3630fbfba24f7ba4680c1cae07919f","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Antibodies to sprifermin/FGF-18","text_display":"Antibodies to sprifermin/FGF-18","cell_row":27,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,1863],[1117,1863],[1117,1899],[1083,1899]],"region":{"top_left_x":1082,"top_left_y":1862,"width":36,"height":38},"line":210,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c489a1c21b74752be92ca6618d7e434","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":27,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1323,1863],[1360,1863],[1360,1899],[1323,1899]],"region":{"top_left_x":1322,"top_left_y":1862,"width":38,"height":38},"line":211,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af4a373b157e43318287541f0d11b81f","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":27,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,1863],[1518,1863],[1518,1899],[1477,1899]],"region":{"top_left_x":1476,"top_left_y":1862,"width":42,"height":38},"line":212,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60b11ce092624ecb82c17cd63f9b1754","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":27,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1719,1863],[1762,1863],[1762,1899],[1719,1899]],"region":{"top_left_x":1719,"top_left_y":1862,"width":44,"height":38},"line":213,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"749689d9609642d6803cc2e3efc35412","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":27,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1906],[565,1906],[565,1947],[247,1947]],"region":{"top_left_x":246,"top_left_y":1905,"width":319,"height":43},"line":214,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b0efab96faa4d2abd651979147a558a","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"PK serum collection \\({ }^{(9)}\\)","text_display":"PK serum collection \\({ }^{(9)}\\)","cell_row":28,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9951171875,"confidence_rate":0.9998560464688708},{"cnt":[[1083,1915],[1117,1915],[1117,1951],[1083,1951]],"region":{"top_left_x":1082,"top_left_y":1914,"width":36,"height":38},"line":215,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"707ddaf94c3f4ef0a1a75496f63f526f","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":28,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1241,1915],[1273,1915],[1273,1951],[1241,1951]],"region":{"top_left_x":1240,"top_left_y":1914,"width":34,"height":38},"line":216,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46fdbd7036e845709fe17e28a961e59f","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":28,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1635,1915],[1676,1915],[1676,1951],[1635,1951]],"region":{"top_left_x":1634,"top_left_y":1914,"width":42,"height":38},"line":217,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e8c2936968c45198f329b57797121c9","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":28,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1958],[667,1958],[667,1999],[247,1999]],"region":{"top_left_x":246,"top_left_y":1957,"width":421,"height":42},"line":218,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5dd473ab9e0444b962e33ec8cdbafff","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Biomarker serum collection \\({ }^{(10)}\\)","text_display":"Biomarker serum collection \\({ }^{(10)}\\)","cell_row":29,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,1966],[1117,1966],[1117,2003],[1083,2003]],"region":{"top_left_x":1082,"top_left_y":1966,"width":36,"height":38},"line":219,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b749e928f9d145a9ad67be10ecb6da29","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":29,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1635,1966],[1676,1966],[1676,2003],[1635,2003]],"region":{"top_left_x":1634,"top_left_y":1966,"width":42,"height":38},"line":220,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a53f473f636433bba1985731f7b44e5","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":29,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2018],[613,2018],[613,2051],[247,2051]],"region":{"top_left_x":246,"top_left_y":2018,"width":367,"height":33},"line":221,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa5f4e2fe19249f2a71a9537da44e424","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Biomarker urine collection","text_display":"Biomarker urine collection","cell_row":30,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,2018],[1117,2018],[1117,2055],[1083,2055]],"region":{"top_left_x":1082,"top_left_y":2018,"width":36,"height":38},"line":222,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f1d83aabfa741658fbe354636ad7332","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":30,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[1635,2018],[1676,2018],[1676,2055],[1635,2055]],"region":{"top_left_x":1634,"top_left_y":2018,"width":42,"height":38},"line":223,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f98951b6557543eaae390acb66cee1e8","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":30,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2062],[600,2062],[600,2107],[247,2107]],"region":{"top_left_x":246,"top_left_y":2061,"width":354,"height":47},"line":224,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d790f75f9bd641f1865ffb64ed29cf12","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"PGt sample collection \\({ }^{(11)}\\)","text_display":"PGt sample collection \\({ }^{(11)}\\)","cell_row":31,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999868000736574},{"cnt":[[769,2064],[1856,2064],[1856,2107],[769,2107]],"region":{"top_left_x":768,"top_left_y":2063,"width":1088,"height":45},"line":225,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"016e554c2d9f4dbe81b359805ec2ffab","type":"table_spanning_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","children_ids":["28a5e50ec75e40c496e6da642e7262ec"],"text":"","text_display":"One sample needed. Can be obtained at any trial visit, preferably at baseline.","cell_row":31,"cell_column":1,"cell_row_span":1,"cell_col_span":13},{"cnt":[[775,2066],[1851,2066],[1851,2107],[775,2107]],"region":{"top_left_x":775,"top_left_y":2066,"width":1077,"height":42},"line":226,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28a5e50ec75e40c496e6da642e7262ec","type":"simple_cell","conversion_output":false,"parent_id":"016e554c2d9f4dbe81b359805ec2ffab","text":"One sample needed. Can be obtained at any trial visit, preferably at baseline.","text_display":"One sample needed. Can be obtained at any trial visit, preferably at baseline.","cell_row":31,"cell_column":1,"cell_row_span":1,"cell_col_span":13,"confidence":1,"confidence_rate":1},{"cnt":[[247,2114],[509,2114],[509,2159],[247,2159]],"region":{"top_left_x":246,"top_left_y":2113,"width":263,"height":47},"line":227,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea3b665d170a4b899e37fd75a96e061f","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Pregnancy test \\({ }^{(12)}\\)","text_display":"Pregnancy test \\({ }^{(12)}\\)","cell_row":32,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[901,2122],[931,2122],[931,2161],[901,2161]],"region":{"top_left_x":900,"top_left_y":2122,"width":31,"height":40},"line":228,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"544565a52693467a800637a7e3b76c8b","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":32,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,2122],[1117,2122],[1117,2161],[1083,2161]],"region":{"top_left_x":1082,"top_left_y":2122,"width":36,"height":40},"line":229,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d100128d3832494092990b2f950375dc","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":32,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1165,2122],[1195,2122],[1195,2161],[1165,2161]],"region":{"top_left_x":1164,"top_left_y":2122,"width":32,"height":40},"line":230,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a631eb13eab4f369fcf798273c11bc2","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":32,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1241,2120],[1273,2120],[1273,2161],[1241,2161]],"region":{"top_left_x":1240,"top_left_y":2120,"width":34,"height":42},"line":231,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ad1553b7b9d484982c78149b913d48d","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":32,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,2122],[1518,2122],[1518,2161],[1477,2161]],"region":{"top_left_x":1476,"top_left_y":2122,"width":42,"height":40},"line":232,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cc74bd0dfce46b982de7d05b7207050","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":32,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1555,2122],[1589,2122],[1589,2161],[1555,2161]],"region":{"top_left_x":1554,"top_left_y":2122,"width":36,"height":40},"line":233,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49b36a2ac5ba4c8ba5469622933df737","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":32,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1633,2122],[1676,2122],[1676,2161],[1633,2161]],"region":{"top_left_x":1632,"top_left_y":2122,"width":44,"height":40},"line":234,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52e3e2b7072d4543968134ec3c24ccf3","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":32,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2170],[509,2170],[509,2203],[247,2203]],"region":{"top_left_x":246,"top_left_y":2170,"width":263,"height":33},"line":235,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4cce017e77348c188397df13f6a4e9e","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"20-meter walk test","text_display":"20-meter walk test","cell_row":33,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999787654211912},{"cnt":[[901,2170],[931,2170],[931,2213],[901,2213]],"region":{"top_left_x":900,"top_left_y":2170,"width":31,"height":44},"line":236,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"988cc2616df24fc8b883ead123e60bff","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":33,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[996,2170],[1031,2170],[1031,2213],[996,2213]],"region":{"top_left_x":995,"top_left_y":2170,"width":36,"height":44},"line":237,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32f80c6179504bfbad37aebfa7bbcde6","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":33,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1397,2170],[1431,2170],[1431,2213],[1397,2213]],"region":{"top_left_x":1396,"top_left_y":2170,"width":36,"height":44},"line":238,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4359ab1ce78749af8b8b949a301a01bb","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":33,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,2170],[1518,2170],[1518,2213],[1477,2213]],"region":{"top_left_x":1476,"top_left_y":2170,"width":42,"height":44},"line":239,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30a73036791b40ffa5df4d1cfc2bd18b","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":33,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1814,2170],[1851,2170],[1851,2213],[1814,2213]],"region":{"top_left_x":1814,"top_left_y":2170,"width":38,"height":44},"line":240,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5084083d8ac049799373cc7e2d4f1a50","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":33,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[247,2213],[528,2213],[528,2261],[247,2261]],"region":{"top_left_x":246,"top_left_y":2213,"width":283,"height":48},"line":241,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcaaf6d08ea4435889c2e5b987bde9aa","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Knee X-ray(s) \\({ }^{(13)(14)}\\)","text_display":"Knee X-ray(s) \\({ }^{(13)(14)}\\)","cell_row":34,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[890,2222],[931,2222],[931,2265],[890,2265]],"region":{"top_left_x":889,"top_left_y":2222,"width":42,"height":44},"line":242,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02a79d7807ac4f1281d7000570595b13","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":34,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2265],[556,2265],[556,2311],[247,2311]],"region":{"top_left_x":246,"top_left_y":2265,"width":311,"height":46},"line":243,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6e49c87dfc04c1381478d07e688fe14","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Target knee MRI \\({ }^{(3)(14)}\\)","text_display":"Target knee MRI \\({ }^{(3)(14)}\\)","cell_row":35,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990236759185791,"confidence_rate":0.9999712709716212},{"cnt":[[1083,2274],[1117,2274],[1117,2317],[1083,2317]],"region":{"top_left_x":1082,"top_left_y":2273,"width":36,"height":45},"line":244,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2740f7a7e428401b8fd336ce83d792a5","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":35,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,2274],[1518,2274],[1518,2317],[1477,2317]],"region":{"top_left_x":1476,"top_left_y":2273,"width":42,"height":45},"line":245,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96ec3b1d580f4be295e3560b77be3896","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":35,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,2317],[613,2317],[613,2363],[247,2363]],"region":{"top_left_x":246,"top_left_y":2317,"width":367,"height":46},"line":246,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc84ae530aa74cb9ab0e37a0059d8145","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"Synovial fluid collection \\({ }^{(15)}\\)","text_display":"Synovial fluid collection \\({ }^{(15)}\\)","cell_row":36,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,2326],[1117,2326],[1117,2369],[1083,2369]],"region":{"top_left_x":1082,"top_left_y":2325,"width":36,"height":45},"line":247,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e5219bb0682415a8c6d9a3050bd20ee","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":36,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1165,2326],[1204,2326],[1204,2369],[1165,2369]],"region":{"top_left_x":1164,"top_left_y":2325,"width":40,"height":45},"line":248,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e326e3df00cf4e2f9b503b0615155a51","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":36,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1241,2326],[1273,2326],[1273,2369],[1241,2369]],"region":{"top_left_x":1240,"top_left_y":2325,"width":34,"height":45},"line":249,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9db9ac3db849435ba6e0b63456fca51d","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":36,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,2326],[1518,2326],[1518,2369],[1477,2369]],"region":{"top_left_x":1476,"top_left_y":2325,"width":42,"height":45},"line":250,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7542a04320a40858cd35b1f4bd56070","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":36,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1555,2326],[1589,2326],[1589,2369],[1555,2369]],"region":{"top_left_x":1554,"top_left_y":2325,"width":36,"height":45},"line":251,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96f03c43c3b0458c939c76d4f7b1186a","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":36,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1635,2326],[1676,2326],[1676,2369],[1635,2369]],"region":{"top_left_x":1634,"top_left_y":2325,"width":42,"height":45},"line":252,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"420efebb709a4338b1527355bfcf25f6","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":36,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[247,2378],[515,2378],[515,2415],[247,2415]],"region":{"top_left_x":246,"top_left_y":2377,"width":270,"height":38},"line":253,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f06c2b9938c343aab4dcc73dd98535ce","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"i.a. injection of IMP","text_display":"i.a. injection of IMP","cell_row":37,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1083,2378],[1117,2378],[1117,2421],[1083,2421]],"region":{"top_left_x":1082,"top_left_y":2377,"width":36,"height":45},"line":254,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b7a625e43b34742b329d2344192f4c8","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":37,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1165,2378],[1204,2378],[1204,2421],[1165,2421]],"region":{"top_left_x":1164,"top_left_y":2377,"width":40,"height":45},"line":255,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69526f6a22ca4f5baf969428891f2a79","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":37,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1241,2378],[1273,2378],[1273,2421],[1241,2421]],"region":{"top_left_x":1240,"top_left_y":2377,"width":34,"height":45},"line":256,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2917dc67050c4f78809baea799b6bfd2","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":37,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1477,2378],[1518,2378],[1518,2421],[1477,2421]],"region":{"top_left_x":1476,"top_left_y":2377,"width":42,"height":45},"line":257,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f37f8806ba0e4defa68a28380101cf42","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":37,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1555,2378],[1589,2378],[1589,2421],[1555,2421]],"region":{"top_left_x":1554,"top_left_y":2377,"width":36,"height":45},"line":258,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6700883fe0fb402aacbe2dee3397d481","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":37,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1633,2378],[1676,2378],[1676,2421],[1633,2421]],"region":{"top_left_x":1632,"top_left_y":2377,"width":44,"height":45},"line":259,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"808acc0a797d4814b4904181ac2e4de4","type":"simple_cell","conversion_output":false,"parent_id":"9b611a73db144d24a7c8b08f8e47019c","text":"X","text_display":"X","cell_row":37,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,2428],[836,2428],[836,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2427,"width":592,"height":42},"line":260,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b525f8b753cf4997b2937caee53e2398","type":"text","conversion_output":true,"text":"Table footnotes appear on following page.","text_display":"\n\nTable footnotes appear on following page.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[436,2509],[436,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":193,"height":37},"line":261,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90a87b0fa89a41b8bde7fb05c1c65be0","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2544],[389,2544],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2543,"width":145,"height":44},"line":262,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2c5bccfb0614723a09ad95d1b8c1adc","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1491,2527],[1603,2527],[1603,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2526,"width":112,"height":38},"line":263,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4445431439e2493bb6284803050f0137","type":"page_info","conversion_output":false,"text":"109/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1783,2496],[1904,2496],[1904,2610],[1783,2610]],"region":{"top_left_x":1783,"top_left_y":2496,"width":121,"height":115},"line":264,"column":0,"font_size":88,"is_printed":true,"is_handwritten":false,"id":"80ef3916d17149dda60692d519c546ea","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.99609375,"confidence_rate":0.9993478961586658}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-110","page":110,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb0c938637ff466383d7fb35f3f587ce","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a92898d212142b595e1338d0bc95440","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eaeb54d5ea104b71b5ab5583126beeed","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,279],[1867,279],[1867,320],[245,320]],"region":{"top_left_x":244,"top_left_y":279,"width":1623,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"987663534b5245488baf48416a0f071e","type":"text","conversion_output":true,"text":"Abbreviations: AEs: adverse events; ECG: electrocardiogram; i.a: intra-articular; ICOAP: Measure of Intermittent and","text_display":"\n\nAbbreviations: AEs: adverse events; ECG: electrocardiogram; i.a: intra-articular; ICOAP: Measure of Intermittent and","confidence":0.998046875,"confidence_rate":0.999983842817836},{"cnt":[[245,314],[1785,314],[1785,354],[245,354]],"region":{"top_left_x":244,"top_left_y":313,"width":1542,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"393692ce277843b0adbb5cddb3de39b3","type":"text","conversion_output":true,"text":"Constant Osteoarthritis Pain; KOOS: Knee Injury and Osteoarthritis Outcome Score; MRI: magnetic resonance","text_display":" Constant Osteoarthritis Pain; KOOS: Knee Injury and Osteoarthritis Outcome Score; MRI: magnetic resonance","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,352],[1790,352],[1790,391],[245,391]],"region":{"top_left_x":244,"top_left_y":352,"width":1546,"height":40},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39916f355bc2420eacadea1814b4c6fb","type":"text","conversion_output":true,"text":"imaging; NRS: numerical rating scale; PGIC: Patient Global Impression of Change; PK: pharmacokinetic; QOL:","text_display":" imaging; NRS: numerical rating scale; PGIC: Patient Global Impression of Change; PK: pharmacokinetic; QOL:","confidence":0.9956088066101074,"confidence_rate":0.9999603533715575},{"cnt":[[245,387],[1474,387],[1474,428],[245,428]],"region":{"top_left_x":244,"top_left_y":386,"width":1230,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f90f11059a0c458381afbbe7312db262","type":"text","conversion_output":true,"text":"quality of life; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index","text_display":" quality of life; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[245,443],[1803,443],[1803,483],[245,483]],"region":{"top_left_x":244,"top_left_y":442,"width":1559,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c2171cc34c64c8899c704546e4d4560","type":"text","conversion_output":true,"text":"Subjects will be requested to discontinue the intake of any pain medications for at least 5 half-lives before a visit","text_display":"\n\nSubjects will be requested to discontinue the intake of any pain medications for at least 5 half-lives before a visit","confidence":1,"confidence_rate":1},{"cnt":[[245,477],[763,477],[763,522],[245,522]],"region":{"top_left_x":244,"top_left_y":476,"width":519,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d5aac6ebbeb4f5a8c423126b4f5dabe","type":"text","conversion_output":true,"text":"involving completion of the WOMAC.","text_display":" involving completion of the WOMAC.","confidence":1,"confidence_rate":1},{"cnt":[[245,535],[1828,535],[1828,578],[245,578]],"region":{"top_left_x":244,"top_left_y":534,"width":1585,"height":44},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc76639dd1a8409ea63ad998c4010ec1","type":"text","conversion_output":true,"text":"At visits where IMP is administered, all procedures should be performed before dosing unless otherwise specified.","text_display":"\nAt visits where IMP is administered, all procedures should be performed before dosing unless otherwise specified.","confidence":1,"confidence_rate":1},{"cnt":[[245,571],[1876,571],[1876,612],[245,612]],"region":{"top_left_x":244,"top_left_y":571,"width":1632,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df815b53e61d465bafa809a4f8e548ca","type":"text","conversion_output":true,"text":"Subject questionnaires (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS in both knees, pain in other","text_display":" Subject questionnaires (WOMAC, PGA, KOOS QOL, KOOS Symptom Index, PGIC, NRS in both knees, pain in other","confidence":1,"confidence_rate":1},{"cnt":[[245,608],[1794,608],[1794,649],[245,649]],"region":{"top_left_x":244,"top_left_y":608,"width":1550,"height":41},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71e94698741541ab86bd0f80e19ed77a","type":"text","conversion_output":true,"text":"joints, MOS SF-36, and ICOAP) should be completed before any other procedures are performed; the WOMAC","text_display":" joints, MOS SF-36, and ICOAP) should be completed before any other procedures are performed; the WOMAC","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[610,645],[610,685],[245,685]],"region":{"top_left_x":244,"top_left_y":644,"width":367,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f39479529c24ed687e95bb6ed5a5cce","type":"text","conversion_output":true,"text":"should be completed first.","text_display":" should be completed first.","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1867,700],[1867,741],[245,741]],"region":{"top_left_x":244,"top_left_y":700,"width":1623,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f30e07f7eadb476b9aa2057d2e09cfd5","type":"text","conversion_output":true,"text":"At each visit, subjects will be given trial diaries which will be collected and reviewed at the following visit (see Section","text_display":"\n\nAt each visit, subjects will be given trial diaries which will be collected and reviewed at the following visit (see Section","confidence":0.9824380874633789,"confidence_rate":0.9998626609626543},{"cnt":[[245,735],[342,735],[342,776],[245,776]],"region":{"top_left_x":244,"top_left_y":734,"width":98,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b38aebae70e14701adf182a5f2012d5a","type":"text","conversion_output":true,"text":"7.1.1).","text_display":" 7.1.1).","confidence":0.99951171875,"confidence_rate":0.9999593007867263},{"cnt":[[247,786],[1747,786],[1747,827],[247,827]],"region":{"top_left_x":247,"top_left_y":786,"width":1500,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c415d2229f14d9ead07d37e0d878f23","type":"text","conversion_output":true,"text":"1. After informed consent for the trial is obtained, screening procedures can be spread out over this period if","text_display":"\n1. After informed consent for the trial is obtained, screening procedures can be spread out over this period if","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1841,821],[1841,862],[245,862]],"region":{"top_left_x":244,"top_left_y":820,"width":1598,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc564203ad764e758727a37f0422ca22","type":"text","conversion_output":true,"text":"necessary for logistical reasons. However, subject questionnaires (WOMAC question 1, PGA, and NRS pain) must","text_display":" necessary for logistical reasons. However, subject questionnaires (WOMAC question 1, PGA, and NRS pain) must","confidence":1,"confidence_rate":1},{"cnt":[[245,859],[1869,859],[1869,898],[245,898]],"region":{"top_left_x":244,"top_left_y":859,"width":1626,"height":40},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e2c90d4b944470a8973f64d7ba2c79d","type":"text","conversion_output":true,"text":"be completed on the same day at the beginning of screening. Subjects not taking analgesic medication at the time of","text_display":" be completed on the same day at the beginning of screening. Subjects not taking analgesic medication at the time of","confidence":1,"confidence_rate":1},{"cnt":[[245,894],[1841,894],[1841,935],[245,935]],"region":{"top_left_x":244,"top_left_y":893,"width":1598,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd8f2dc94b2a4485b19e57d80f81e4a3","type":"text","conversion_output":true,"text":"informed consent signature can have Visit 1a and 1b procedures completed at the same visit. If Visit 1a and 1b are","text_display":" informed consent signature can have Visit 1a and 1b procedures completed at the same visit. If Visit 1a and 1b are","confidence":0.990243194391951,"confidence_rate":0.9999176108301423},{"cnt":[[245,930],[1745,930],[1745,969],[245,969]],"region":{"top_left_x":244,"top_left_y":930,"width":1501,"height":39},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0594bd960a00414491e23d073a6d5056","type":"text","conversion_output":true,"text":"being combined do not repeat the WOMAC Question 1 or the NRS pain score. See Section 7.1.2 for details.","text_display":" being combined do not repeat the WOMAC Question 1 or the NRS pain score. See Section 7.1.2 for details.","confidence":1,"confidence_rate":1},{"cnt":[[245,980],[1876,980],[1876,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":979,"width":1632,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ed39ff9e1334ee7aba00fd20c42b22a","type":"text","conversion_output":true,"text":"2. Study visits, beginning with Visit 3, should be planned for the study day specified in the protocol. If it is not possible","text_display":"\n2. Study visits, beginning with Visit 3, should be planned for the study day specified in the protocol. If it is not possible","confidence":0.991706371307373,"confidence_rate":0.9999359388813943},{"cnt":[[245,1018],[1852,1018],[1852,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1018,"width":1608,"height":37},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4a569f8586042cf871bfb6c9c397ad2","type":"text","conversion_output":true,"text":"to complete the visit on the planned day, or if an emergency occurs, the protocol does allow for some exceptions as","text_display":" to complete the visit on the planned day, or if an emergency occurs, the protocol does allow for some exceptions as","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1854,1053],[1854,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1052,"width":1611,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad4c940619ef4f4dbd4003030837aecc","type":"text","conversion_output":true,"text":"long as the minimum and maximum between injection and between treatment cycle restrictions are maintained. See","text_display":" long as the minimum and maximum between injection and between treatment cycle restrictions are maintained. See","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[591,1087],[591,1124],[245,1124]],"region":{"top_left_x":244,"top_left_y":1087,"width":347,"height":37},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbfa1a7fad5f46fd87cabf1e57c4ff0a","type":"text","conversion_output":true,"text":"Section 7.1.1 for details.","text_display":" Section 7.1.1 for details.","confidence":1,"confidence_rate":1},{"cnt":[[245,1139],[1796,1139],[1796,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1138,"width":1553,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"045ff322d4f34a928ed0f540c8ced917","type":"text","conversion_output":true,"text":"3. If it is not possible to schedule an MRI scan for the same day as the other baseline assessments for logistical","text_display":"\n3. If it is not possible to schedule an MRI scan for the same day as the other baseline assessments for logistical","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1779,1173],[1779,1214],[245,1214]],"region":{"top_left_x":244,"top_left_y":1173,"width":1535,"height":41},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"400fbcf2ce4d472b86f17b8e6fa04b1f","type":"text","conversion_output":true,"text":"reasons, the baseline MRI may be performed up to 3 days after confirmation of eligibility by baseline WOMAC.","text_display":" reasons, the baseline MRI may be performed up to 3 days after confirmation of eligibility by baseline WOMAC.","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[245,1210],[1846,1210],[1846,1250],[245,1250]],"region":{"top_left_x":244,"top_left_y":1209,"width":1602,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9f57f35b7c74c9fb08ad87c5d477647","type":"text","conversion_output":true,"text":"Randomization and IMP administration will then take place on the day of the baseline MRI (following the scan), and","text_display":" Randomization and IMP administration will then take place on the day of the baseline MRI (following the scan), and","confidence":1,"confidence_rate":1},{"cnt":[[245,1246],[1768,1246],[1768,1287],[245,1287]],"region":{"top_left_x":244,"top_left_y":1246,"width":1525,"height":41},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c4cb5cfa3494537a432721557a4c3a6","type":"text","conversion_output":true,"text":"subsequent visits will be planned relative to the day of IMP administration. If baseline procedures are done on","text_display":" subsequent visits will be planned relative to the day of IMP administration. If baseline procedures are done on","confidence":1,"confidence_rate":1},{"cnt":[[245,1280],[1876,1280],[1876,1321],[245,1321]],"region":{"top_left_x":244,"top_left_y":1280,"width":1632,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e279253c6ad47319881e0f1f1ba3b2a","type":"text","conversion_output":true,"text":"different days, those shown in the first column must be performed on the day of the WOMAC, and those shown in the","text_display":" different days, those shown in the first column must be performed on the day of the WOMAC, and those shown in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1319],[1828,1319],[1828,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1319,"width":1585,"height":41},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51ad0693cc44447f8db399666b31b081","type":"text","conversion_output":true,"text":"second column must be performed on the day of the MRI (the scan must be performed before IMP injection). If an","text_display":" second column must be performed on the day of the MRI (the scan must be performed before IMP injection). If an","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1833,1354],[1833,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1353,"width":1589,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13a24141d1a64a67b9dc9c36db4be641","type":"text","conversion_output":true,"text":"MRI scan can be scheduled on the same day as the confirmation of eligibility, all procedures listed for the baseline","text_display":" MRI scan can be scheduled on the same day as the confirmation of eligibility, all procedures listed for the baseline","confidence":1,"confidence_rate":1},{"cnt":[[245,1388],[1076,1388],[1076,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1387,"width":833,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a967d22031e24e8393f6f9dae2a7e229","type":"text","conversion_output":true,"text":"visit (in either column) must be performed on the same day.","text_display":" visit (in either column) must be performed on the same day.","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[999,1439],[999,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1439,"width":756,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63b6a8ff43ca48b1850c21ca3a610ca0","type":"text","conversion_output":true,"text":"4. Study informed consent and separate PGt consent.","text_display":"\n4. Study informed consent and separate PGt consent.","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1742,1487],[1742,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1499,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a53ea667e794446a99f4fd1d524efdb7","type":"text","conversion_output":true,"text":"5. All pain medications must be withheld for at least 5 half-lives before any visit with a WOMAC assessment","text_display":"\n5. All pain medications must be withheld for at least 5 half-lives before any visit with a WOMAC assessment","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[574,1525],[574,1566],[245,1566]],"region":{"top_left_x":244,"top_left_y":1525,"width":330,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4ff9075f3e4481192f336298b0743fc","type":"text","conversion_output":true,"text":"beginning with Visit 1b.","text_display":" beginning with Visit 1b.","confidence":0.99951171875,"confidence_rate":0.999983158745329},{"cnt":[[245,1573],[1369,1573],[1369,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1572,"width":1125,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1247de6961d4d60acf3a3299d9ee36d","type":"text","conversion_output":true,"text":"6. Sitting systolic and diastolic blood pressure, heart rate, and body temperature.","text_display":"\n6. Sitting systolic and diastolic blood pressure, heart rate, and body temperature.","confidence":1,"confidence_rate":1},{"cnt":[[245,1624],[1276,1624],[1276,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1624,"width":1033,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"596d9626232c4333b2198bf9b4d3fa5f","type":"text","conversion_output":true,"text":"7. Including height and weight at screening and weight at Week \\(26 /\\) Visit 7.","text_display":"\n7. Including height and weight at screening and weight at Week \\(26 /\\) Visit 7.","confidence":0.910836623981595,"confidence_rate":0.9988617247319875},{"cnt":[[245,1671],[1867,1671],[1867,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1671,"width":1623,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24cfd36ea4da4587a16bec48124cc424","type":"text","conversion_output":true,"text":"8. Hematology, biochemistry, urinalysis. See Appendix B for complete list. Coagulation tests will be performed locally","text_display":"\n8. Hematology, biochemistry, urinalysis. See Appendix B for complete list. Coagulation tests will be performed locally","confidence":1,"confidence_rate":1},{"cnt":[[245,1710],[726,1710],[726,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1710,"width":483,"height":41},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"adc0a1b0cd2a484284d68c45b4be4ad5","type":"text","conversion_output":true,"text":"at the screening assessment only.","text_display":" at the screening assessment only.","confidence":1,"confidence_rate":1},{"cnt":[[245,1757],[1841,1757],[1841,1800],[245,1800]],"region":{"top_left_x":244,"top_left_y":1757,"width":1598,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e188361a2e246d88766d6d12ad5a8a1","type":"text","conversion_output":true,"text":"9. Blood samples for PK will be taken pre-dose at Week \\(0 /\\) Visit 2 , and thereafter 2 hours after the last dose of each","text_display":"\n9. Blood samples for PK will be taken pre-dose at Week \\(0 /\\) Visit 2 , and thereafter 2 hours after the last dose of each","confidence":0.65565052633292,"confidence_rate":0.9968071733536925},{"cnt":[[245,1796],[333,1796],[333,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1796,"width":90,"height":41},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6459acb55c15445a8165054e7f1afe52","type":"text","conversion_output":true,"text":"cycle.","text_display":" cycle.","confidence":1,"confidence_rate":1},{"cnt":[[245,1843],[866,1843],[866,1888],[245,1888]],"region":{"top_left_x":244,"top_left_y":1843,"width":622,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2761f1d1932c443dbe9d80658063440a","type":"text","conversion_output":true,"text":"10. Fasting samples for biomarker analysis.","text_display":"\n10. Fasting samples for biomarker analysis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1895],[1115,1895],[1115,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1894,"width":872,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5095fe5484bf4c2b9b9f6c42a1080f57","type":"text","conversion_output":true,"text":"11. PGt samples will be collected for consenting subjects only.","text_display":"\n11. PGt samples will be collected for consenting subjects only.","confidence":1,"confidence_rate":1},{"cnt":[[245,1942],[1835,1942],[1835,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1942,"width":1591,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"673dd426428c43f2b4199465119fbb1e","type":"text","conversion_output":true,"text":"12. Pregnancy testing: serum during screening; urine at subsequent time points (prior to IMP injection) and prior to","text_display":"\n12. Pregnancy testing: serum during screening; urine at subsequent time points (prior to IMP injection) and prior to","confidence":1,"confidence_rate":1},{"cnt":[[245,1981],[541,1981],[541,2022],[245,2022]],"region":{"top_left_x":244,"top_left_y":1980,"width":298,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9c60aceb29b49188ec0021f41a6256b","type":"text","conversion_output":true,"text":"each X-ray and MRI.","text_display":" each X-ray and MRI.","confidence":1,"confidence_rate":1},{"cnt":[[245,2030],[1818,2030],[1818,2073],[245,2073]],"region":{"top_left_x":244,"top_left_y":2030,"width":1574,"height":44},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"254a85ed4a724d50ada5e8aafdbf7a2b","type":"text","conversion_output":true,"text":"13. X-rays of both the target and the contralateral knee will be taken during screening, at Week 104/Visit 22/Early","text_display":"\n13. X-rays of both the target and the contralateral knee will be taken during screening, at Week 104/Visit 22/Early","confidence":0.77978515625,"confidence_rate":0.9979293397979806},{"cnt":[[245,2067],[1772,2067],[1772,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2066,"width":1529,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7e4fee586c04a6da89888e0f2b82aa0","type":"text","conversion_output":true,"text":"Termination, and at the last EFU visits; X-rays of only the target knee will be taken at other time points. During","text_display":" Termination, and at the last EFU visits; X-rays of only the target knee will be taken at other time points. During","confidence":0.9990234375,"confidence_rate":0.9999917896164967},{"cnt":[[245,2103],[1624,2103],[1624,2144],[245,2144]],"region":{"top_left_x":244,"top_left_y":2103,"width":1381,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08092a54a2ac4ccfa1443b0a8eb6da05","type":"text","conversion_output":true,"text":"screening, a long-axis view of the target knee will be taken in addition to the anterior/posterior view.","text_display":" screening, a long-axis view of the target knee will be taken in addition to the anterior/posterior view.","confidence":1,"confidence_rate":1},{"cnt":[[245,2153],[1828,2153],[1828,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2152,"width":1585,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f1ab4e6e9c34765b33f8bba1de68cb7","type":"text","conversion_output":true,"text":"14. At time points where IMP administration is scheduled, X-rays and MRIs may be performed up to 3 days before","text_display":"\n14. At time points where IMP administration is scheduled, X-rays and MRIs may be performed up to 3 days before","confidence":0.96484375,"confidence_rate":0.9996967484658784},{"cnt":[[245,2189],[1824,2189],[1824,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2189,"width":1581,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c553b3da45774e468061a47a3a372f0b","type":"text","conversion_output":true,"text":"the planned day of IMP administration. At time points where there is no IMP administration scheduled, X-rays and","text_display":" the planned day of IMP administration. At time points where there is no IMP administration scheduled, X-rays and","confidence":1,"confidence_rate":1},{"cnt":[[245,2226],[1785,2226],[1785,2267],[245,2267]],"region":{"top_left_x":244,"top_left_y":2225,"width":1542,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b93f99455004c7ba0aa85bc7e3c7462","type":"text","conversion_output":true,"text":"MRIs may be performed within \\(\\pm 4\\) days (DBPC treatment phase) or \\(\\pm 7\\) days (extended follow-up phase) of the","text_display":" MRIs may be performed within \\(\\pm 4\\) days (DBPC treatment phase) or \\(\\pm 7\\) days (extended follow-up phase) of the","confidence":0.9814786752685905,"confidence_rate":0.9998374480636366},{"cnt":[[245,2260],[432,2260],[432,2305],[245,2305]],"region":{"top_left_x":244,"top_left_y":2260,"width":188,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a6933669f734d83a4ea44263d2bb8d9","type":"text","conversion_output":true,"text":"planned day.","text_display":" planned day.","confidence":1,"confidence_rate":1},{"cnt":[[245,2310],[1811,2310],[1811,2353],[245,2353]],"region":{"top_left_x":244,"top_left_y":2309,"width":1568,"height":44},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf03bc5514e341089ee40641df431a5e","type":"text","conversion_output":true,"text":"15. At visits where IMP is injected, synovial fluid will be collected as part of the i.a. injection procedure, using the","text_display":"\n15. At visits where IMP is injected, synovial fluid will be collected as part of the i.a. injection procedure, using the","confidence":1,"confidence_rate":1},{"cnt":[[245,2346],[1818,2346],[1818,2391],[245,2391]],"region":{"top_left_x":244,"top_left_y":2346,"width":1574,"height":46},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa1f85de9a914bacbce0c4ab30b7dacc","type":"text","conversion_output":true,"text":"same needle that will be used for IMP injection. PK will be analyzed in synovial fluid at all indicated sampling time","text_display":" same needle that will be used for IMP injection. PK will be analyzed in synovial fluid at all indicated sampling time","confidence":0.99951171875,"confidence_rate":0.9999959967252418},{"cnt":[[245,2385],[1811,2385],[1811,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2384,"width":1568,"height":42},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76358bfea80345879956c19118623782","type":"text","conversion_output":true,"text":"points. If the volume of synovial fluid collected permits, biomarkers will also be analyzed at Week \\(0 /\\) Visit 2 and at","text_display":" points. If the volume of synovial fluid collected permits, biomarkers will also be analyzed at Week \\(0 /\\) Visit 2 and at","confidence":0.4888032447779551,"confidence_rate":0.9944234567095444},{"cnt":[[245,2419],[483,2419],[483,2456],[245,2456]],"region":{"top_left_x":244,"top_left_y":2419,"width":240,"height":37},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9677842fe07c48a6a096bad6b3bbe41d","type":"text","conversion_output":true,"text":"Week 26/Visit 7.","text_display":" Week 26/Visit 7.","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[438,2509],[438,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":195,"height":37},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df72677cc33240adbd2e4e5465b49c10","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,2548],[389,2548],[389,2587],[245,2587]],"region":{"top_left_x":244,"top_left_y":2548,"width":145,"height":39},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9efe0fe6004e4d4d95152c7f9871b783","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1491,2529],[1596,2529],[1596,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2528,"width":106,"height":36},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f893f689c4143b8bf00b238eb19c5aa","type":"page_info","conversion_output":false,"text":"110/113","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-111","page":111,"lines":[{"cnt":[[245,129],[432,129],[432,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":188,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20c5d3f2450340b4b3d79f7fa954d25d","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,125],[1317,125],[1317,174],[642,174]],"region":{"top_left_x":642,"top_left_y":124,"width":675,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d64d293e42314b86b3734ace3d0112fe","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c81888e4f81f4d6898972e5bde43bfbe","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,316],[389,316],[389,359],[245,359]],"region":{"top_left_x":244,"top_left_y":315,"width":145,"height":44},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee0c13140e52472090ec2c13c2d759e5","type":"figure_label","conversion_output":false,"text":"Table 6","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[593,318],[2004,318],[2004,367],[593,367]],"region":{"top_left_x":592,"top_left_y":317,"width":1413,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fa1d2b5ab5d4796a0d79dd55d3a9ffa","type":"figure_label","conversion_output":true,"text":"Schedule of Trial Procedures for Visits 12 to 22 and Extended Follow-up Visits","text_display":"\n\nSchedule of Trial Procedures for Visits 12 to 22 and Extended Follow-up Visits","confidence":1,"confidence_rate":1},{"cnt":[[226,397],[2546,397],[2546,1803],[226,1803]],"region":{"top_left_x":225,"top_left_y":397,"width":2321,"height":1406},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bacc05cdca6431dbbb049f93dde1579","type":"table","conversion_output":true,"children_ids":["c876fec7b8a74d64b50c24121cdb7f82","c4f9a6213cd94fffab75cc25c6d5bfea","28b8f7ec484344568a1fa67057c1e09f","fb94864db86d4dbaad8b450f189ad8a1","6be0d0e0302a42f7bbd1ce7d2f6dd8d5","022cbcfbed8b42c2b855c516156e13ea","f05cb20934ed40b3bb7497ddb6a23d32","2d09cca8c64e4d8b85afc59d4ac8f634","61e2f3adffbd4d7a94ec572461a439fa","a371181c1c4f408db76180e07801da2a","806f4474c77c4a97bc8f1fc6721658c9","2c47f636154642818663cd103eb9d32d","d85f2b2e17244d7693eb5d29f219fe12","2acdd21edbf84aa6a0d590f95d8c18cd","b8a4758c03654dae9f1adde5393bd9af","fadfdfc67124441698879b1324b2f62f","25d76efdd76e439783c19a6bc94f375d","38133d49ade24e4a9aa7524f60f0ff6d","b390aa494fd5499d844597b22a69125c","aa5f69fc4159409db881f5c76befa311","ab132c3c272347f7a734e65578163145","33dbfc3325a24102b1f04f1cee6de2b5","a1119986192046f78a2063b4cbfd7acf","7abf13dd50614bb0a09ad352fd3ef13e","803c19a69dd040c288ede88787ccb262","1828bb636d9c41389a56ec0e94d2f978","89d462062d3546b0b67931491bb0d90a","fea83c259821438c8ecafbe2c9702f5f","745f27f753c543d7b143d6183eb6d0f9","c5958b7b223843b49815db544cf7f2d3","9d5cb2925821425ca1072743f466b0a1","b915a2d1f1444c18a77f88adcd986824","89378477bfb842e2ba72c9992e7d0617","ddabd1e5fd6e48cba2eac0aa91aea930","f7e508c4696244fdb90cad977e9ae870","35843192bd2d4c21bba611e6c7a316cc","50fd9e680cdf48989256ac2f9b6b4405","ae2a9814e5a74a34be16c423992d63e0","0b2be184e2bd4dbba788335fb44ba6f8","228bbd40a2564c8b982779bfc6729490","074798cd362c4cc0a7083f737ebe644f","8905eb30fa9c4c2ab951e6c2ab4ec2fc","32069f02218d41259d7a73e5422d5eac","6d16e7d4e91c4b3aa9c0bbbd5a53a05e","de1a24591de44043960ea48fe13276e8","8a70444f9dc241b6aca802dad7e5714a","6bebe48239e04d258ebde7e023246dc1","d08da0bb6d9b416cb6cd9458d7702575","b04ec1ce13d9469b97f0248e9509bc61","82d65420fcc448448623ab3b70c33d45","ba0ba6c400a1468790c4a96d1785f54b","ea3670fd3db745278b8f36d4d13505bb","ab177b98b39b48debd8934e4452ce618","48dd6580dfcc41338fdf26ebe28d1a3f","e815febe21064b79b541d46b0f93f572","31f7480cbf44446b877cb555a6948977","4f78b7fa09a04763b2df3fd1b362217e","4eed35e4125041f29c27f7cc76a4adc0","545600990986410da4480d879e9a3f5b","1bacd20e008a464fb5df35f89117c4bb","2accde30e0d54377ad58189ce92a0bb5","ab60c27d640c47a7a835e1a2414d6b03","036fed687b1d429b82e0fa8af9428836","ba3eec6ff0bf402294f96e65faba30bb","f03e5c2af209461b916344fbdc620259","df92a0b35a734f54b3ce08d94a9553e8","355bd6acddb448a28ee2807a772441da","8eb5a9275b684f148564f05fd515a12f","703c70d9e1b949d3b899c80dd33a7b57","3b0b4a0494b045c1830b9165396bbcf5","c70e876f93c34e7d98eb9ea3b66739ee","3d6a64b0217748d3a3eb29b8e151e2f0","6256ef70c6fd4d349d4128916b17a873","645811b4672344dbbee55fdf21a23049","ec6c03ba25224c58a3bd66654b557824","c3e60b3fcaa745458ff4c708e243bd5f","a9500a0cb2cf49afa9bdaac4be1de156","7c84722c7dc24b5fbf08f291d574c17a","5d930e1eab104af79016a9d794030bf3","6cd31aa04eb144628b066d095a2ee641","c1bd2da77a884651b3780bd9e9172ad9","549305d07cce440990804cc40f3c66d3","e84cc9fcae08466193af6a3a7608e122","684e60ef55e642e99a7d469d8960387b","da2d99cb0a48415c942e478da00b4ebf","a935ca71533f4e39b4f8bb708c643ead","415a90cdde2f4ae0aa8f86430b5c2bd5","61b7e90717594f849cb54359db3b90f7","7a1a17d4a41e44ffa9a1cc9850e89660","d8d5d4bacf704e79919b7df7ea9e28e8","f1e36decc24f40e1b2b1124b2c894c00","7d9f84d6d6dc4788aa61f94119a2ff1f","f2be2c79acce4be1beaaf4792f0df93c","f9a4e3a9cf734b85b0e8de7b3ce2a463","ff98c07dbe1d4358b0b083ca801effe5","02d913d36a1447ad840dd72ac6e3878c","2c3ee14b13fc414db1a51e520de693a5","eeb18c66e26645ff9516a65724066a67","66474c2e972e4e1db4bc1e2c078df450","02e6ae7f1acb4cd19ff24ee29b038f32","54cdb5c1466b4603a874ea93c9201aeb","e3d4c94660084e39be6401b4f4407e4f","030de60822504009b718dacd8db10e2a","3e3d2de616324cf9a2d8b96dde9da44f","333e7793cea241aca1b97b1c04c797f6","4a94f116088f43d794b7edf226ad3501","aa3bc4695faf495bb2dfde930f34e3b0","0e49992e767d47b58b36fd0ad5d54118","b89781759e1f45a29ccb3bfa0aa87306","4ea29f5d1c0643f3a39c2a3cd37efaed","00c57534a5c34811a594dcb125f21d17","a00a20aa0b784f8d9741a99382fd92c8","4c770df66b5f4c1a880561064eb3d922","5abc5670b2e44734bee49a2d32bb62e9","088e2680c1664673be5a23fdd09bbea3","0adbb8ab43cf4d7cb879089a0aef0c20","d41e21426d3a4dc1b2eaafe03af4d903","0b35758f14a14628ac76b089f06f6d01","6fce28f505ec4c0e81a3b0d3935457e7","8f8844467b39424d839834949a7df700","b44f8bc337fc42e085fbc9ad03a0a281","7056036b10bc4c5498c35cc0174ed4ea","9bd1858da3d446c681d6e8f95735e42f","79f2cc736daa4224b962f6c055064e77","954785c7eaa64ca294d2942c5b912a56","a2cb1f6491d9428c874d7171384aa5c2","26f905ec9da944a592beac4803c5c7bf","34348599ca434c4185b7958923f8953b","19ee1021d603478980c064b710a630b2","cc726477876948a088a28bc4fe605a44","0c975a338de54a72a14633ec6d3ab6e9","48681852519f4254b626d3e9ee649724","9ed45c78544949578f10bc067ef2ab9c","ba5b12f01e094edc92155c953af98ace","21085dbc66124483966430307e9befa2","2f5159fde41342a8b0d6528d5804a007","9bce71ce95414f83adaa73690237816d","8b367fdd74ce4085bf7fbcd4a9659b37","36a35ee308484ea5a8d0e759c815b96d","4f2afa96d6bb4dcf8f1a21e5cc5f0689","c11d3ca6ef474d76b204ce3f114bc209","c4f14fab06ec4eb0bdf624088d6b4d9b","ee043d34b5234f60abfb9ceeae4c5f75","4be61afe2a0b4c8983288fe49d188575","ba06507225204f6abad9cd34dc5ff614","4d41f9f1e78c47d483cebf82e4ab484e","1316d347d59548a4822ed2e2fb59013c","9ad1f2a317fd471cb387eb4947fba92d","e1ebe23524714b5d8330c6ed312e5ee5","e3d464e6d7e2446f9c94fa20026288c9","93bd2688e87b4e978d453bb830026a38","1b6e8b3212744974b1948e0c9241da12","88ffb1b7959f4928bf9de0524102bc93","f2c02d44d8bb4984864ead7b7340fc42","8e1796e2c458439f96b0422f337fb09c","dabd0160a30b4802aa8ffbbfc2a25cda","222fb00e23f14d9ea8247390bb5bcd49","5836e5033be34bf0921b2e530c61d54f","1a5651c1c08944d4aef1719f223307bb","feabe358d7e44fd3b1e848f4796e78d6","c24e1e7f176449d8959ac8c18d909870","de59f18a7a5e4396ac4aa88163ef9b6a","b75a94da371c4beaa34ef9061beb2a1f","02d114db6ac74a488300c6509098dadf","0ba04d0d70c04b9ba7b3435f388f563f","57a4baf51e9744e7ba913ec8844581c6","14b07f1cbc8741cc80d0fed4f1726fe9","1f8b0119a717434f9a84d6e355cf780d","1337a3b6fb804474b864e7ae4e8524f7","d7f3bdd59d8241c5a9bdb2cb7c5ccc9f","8ffe292d61ce445c9234acd077a8f956","83c73350e5f24ca7b68f05a016d302e8","fa2d29ead7e84a9ea793277ce3fe7486","76858b6e6a434be5ad1f0dfc6ac08061","ea08a5bacbe34bda9dec1908f154b378","6556ca605c8a40e9a742ff020fdec8db","5ef6f935626a46dfb04dbae9165cfbea","ec477bb13c7d4ab6b8d05e171d9dfbf2","130555bab23548a299e8f0d393208f49","80bb52edacec47e980f15fe96dec4895","813245316a9046f78c3f6c9279d021b9","d112df749dc1451eb26d28707af2e557","d468803f935c43099f683cd9c66d7550","81e3c8de87e8459288ef9af95a697830","e0ad9fdd7ca04f0d9ebe2f98d1003d93","ee86e1e9a4fb4aa7b9d694457f2a89b6","0f1964effbec43d583916d35af2e0455","d095c89082344aa5b104112316d44338","5c8e88316e174541808dfff24764ea20","df747c7af0c6421cb4d6a5d36eedd88b","e07d440b45a041609f00c277d77facf8","b447a3195ed847419b777197aa3c8137","b678818f967c4670ab70c20a149f4667","e5a882802308440ca69e8433094427b5","0bc0d41c80ca4c3a930c547ea0371545","31515d1074b543798d0c1c77f3f47108","191664a79d354704a0db8fc740412d52","2c02e043a0804ce1bdcc744c1e88da89","5b128d42877244aba081f9556f5801ad","d6091a38e3934b10a9139f7a506ca79a","5a4688a9214243d891b311296c3f90f8","495b0b01dc8142e797f698472c346ed0","10754727412e457698e80512f365bf15","74266df25e354245bf123d3510b6e95b","c251bfa513454e6f86545a01a2eb58be","2ade958fddaf44f084e376e26aec33fb","69f955f50a9146ff8c432da958cc4637","047942e380454ea2bb0cb4ae41f84b29","d1b97566eed842bea986c6fcc96632be","c402be80476346c0b47389c5b8c9d24b","052215ad5c9d4715b09df3ea4d941e0b","699c5cc5b0b443f39ba5c2ddaa1da3b9","c2a64f64c70d49a18bee6f12bef3007c","8a161c1158f645898647a6535c57fde5","269351ab4a7a4135836779f1950bfe89","0e2addd519554c39bc1131cc3517d335","848b7f6774e142e6a8359dbf579fadfc","1f06187267fa46749ef50f28b458f9af","b1354d08e2a3423fada6cccc12ac4f21","57f75a543b2a4e3d8acca5772869619e","5717f64d33664db08f6d3d2934f744b2","9528863569404e5c82a826ac96d97c75","ff0d36c6d9984b87b86577b5296ec509","7e6773cc9024448ca62de6584593f2b7","0bdc83e3b9bc4afa87eb1559cb922edc","f1310ded132444d99bc9d76a1dc7e537","54b2db6a1bc54564b88825994a67667e","39e8aeb892ea49c6a34a3d1e61ad7bfb","d610d1635f484c7ba0c5f6356ba72ea1","3faaf8bfb03946f8929fafeffa76ffba","270c64ab5f344f50b68e3674fcf3f00a","a0f87b65cd08414ca7cc5f76d07c6b9a","be18b9e8c6b9454a884ab7c8feaadb55","f319f2a4a0c145309657fb80918c9841","c78ca20d20904e8cb5c0fbfaba27a240","421b917c375d4a91abbfb9b886294d1a","4417f8d1fbf24f638251b3128cbbb1a6","b4c6363c7a54424fa5732b44ad9cac25","4acf6993089c4bc5b5fef30abf8fbbe8","6a0030b0968a462bb947c65e2d4861b1","3ec2e0a839a549258d4c3367885bd0e4","55a7c21eb0f84a2e946b2a1908d648d8","15992090d86b489ca80aa20dc76d9fbf","1128201375e249cd8e9d0817736b685b","227dcae16efd4447a1b4541b91f4290c","ce19511917c442af8d07b80f46e16308","f031f4dfab71467c9399449e5215f172","6d37bb4999f64b7fae656a2d568ffbf5","b03f21a642a34c89b951706604a253f7","fc23b93d82414845af2dacb3de0b11c5","16aa076a3475447ba021581851c23115","39d1ab0dc03f441bbb3823acef4ada3c","7e966b534b6c49cd95e0781d3a217f03","93f4d9c8829d4360bb1447daacef32dc","00276ee2230d456b951724bca22a6d01","95fea570a5de4251b063ceb55be35ec4","5cd1bf72e7b746ebacb919a4dd3de7b7","a284c88b780f4ce4939a5e4cc01abde0","fdd51f4465a3452495b1a6ba6c67f039","8cb313a248b94d2ebdde1bf96ecf8065","cfd72496a5ae4c019938fef964d38449","beba654f290f4506bbac8824a1ecbfeb","37348774b8b248d294ab30f71b923485","76bda7dc194e4bd59aca0874ab76a461","49579cd53ca5486eaa326269f4f4b005","8354a692989443b5b0fcd524fae1083f","c5f15985ca8e483fb44b190639e0deff","880023b0b2754411b16b6257407eedd3","b4bb7c6ab83344c5b86dd7f9ca4cca28","2720b4e32001401bbf2adfe6a8bcf00d","2f19262b0b684660becf14a3665808d5","4229c1364df240e6b600e1dec6d33631","0ad3ccaca17b44fd95a6cf138f2c42bf","f912e6dd7e5a46cda6586d766e05f2f3","aac18f861b154107afa6987c529a8024","5e27cd4ebb24454c9a33084ce54600c2","a1686edf8fe340c1ba637f3a416c2135","677600780e2444499a6eaac7b20913b4","845798bfa40747d3b966e7388f543eac","84a394774f564455bc68ac2de9e27fd3","151e5c033cd044dabff1797a4c1fc9ad","6dfdb47f1c494736a706b29ffaae1e84","ed29230671ad4e1a842ae25ebcd69ff4","3fcee533b6c2418b8766c91cde9e6683","5bf77b35feb242ce88c01345de41fd75","0e3f9569394343748b1af3f8a896f25f","c9f2dacb6199470fb83692553c5d6eff","183cc98e0af047e5b9ec62b9d5aa0113","06e64192d87748bc875a39389fa53b38","c74b93c44d364bdf954f59b4b6a34f25","716b9dd9cafa4d75b9fd00303f236667","744e9036499d434db21db7ab15ed06ce","f276806fbbe74560a8ddd94baf8265d6","1694bb7cd27c490895d00cc13f32d3fc","87e250ad29bf489fadcfbcf0114989bb","eab15d460b6b416081032cff9977c2cd","13ef0fa3648a477b9bfab4729b93252b","7868e71ff417475f8a905ace0bd72085","1d180e3a15b04957a35ee05cf9ce65cb","22d50afca7314de39a2fea6060b2d9bc","7af309a8347542008ce01e8798e04ef7","0080a8b73e4d4de8bbc14ba404f39c41","f8191fa77cea4817aef4f407ac42c0da","9ac8127b57a349298d6c5f7c106fe07e","1d04e8bc30184d13b1f7e9f950217cdb","89da0053b9ca4b3aad34ffb2800a8eed","f287f82494f24900a36a7b1e3f6d7ea9","4a5dd90e11194b3ca797e0f754671ac9","98608ed58494404db07a01256b4ba4d3","2a940558961b45f6b60d006535dccb16","0f6a341d6e054928a952d944526d36da","66779385501f4fdba6f5e20e8d1a173a","328234546c1b4bc59f0f04b4d6dd2ce7","d7d21d9a2801458a92ee0c81566606d5","2ef0cfc7559f4f2a89aecc592b04ae6c","f98710ec043e4b73ab7c13b83cae2e16","1e6273f1231842b49af369193bdf538b","a30703f615164fa38ceaf7d2016c60cb","52d19a6c381945e39d7374b4951b0226","9be5936c8c3347dbbdedf409d468d15a","8133eaa897004a8f93aa6ad817dc9882"],"selected_labels":["ee0c13140e52472090ec2c13c2d759e5","0fa1d2b5ab5d4796a0d79dd55d3a9ffa"],"text":"\\begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|l|l|l|l|l|l|l|}\n\\hline Visit & V12 & V13 & V14 & V15 & V16 & V17 & V18 & V19 & V20 & V21 & V22/ ET & V23 (EF1) & V24 (EF2) & V25 (EF3) & V26 (EF4) & V27 (EF5) & V28 (EF6) \\\\\n\\hline Week \\({ }^{ ( 1 ) }\\) & 52 & 53 & 54 & 55 & 64 & 78 & 79 & 80 & 81 & 90 & 104 & 130 & 156 & 182 & 208 & 234 & 260 \\\\\n\\hline Withdraw of analgesia prior to visit & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline WOMAC & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline PGA & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline KOOS QOL and Symptom Index & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline PGIC & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline NRS in both knees & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline Pain in other joints & X & & & & & X & & & & & X & X & X & X & X & X & X \\\\\n\\hline MOS SF-36 & X & & & & & X & & & & & X & X & X & X & X & X & X \\\\\n\\hline ICOAP & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline AEs & \\multicolumn{17}{|c|}{Continuous} \\\\\n\\hline Concomitant medications & \\multicolumn{17}{|c|}{Continuous} \\\\\n\\hline Surgical procedures (target knee) & \\multicolumn{17}{|c|}{Continuous} \\\\\n\\hline Review of subject diaries & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline Vital signs \\({ }^{(2)}\\) & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline Physical examination \\({ }^{(3)}\\) & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline ECG & X & & & & & & & & & & X & & & & & & \\\\\n\\hline Clinical laboratory specimens \\({ }^{(4)}\\) & X & & & & & X & & & & & X & X & X & X & X & X & X \\\\\n\\hline Antibodies to sprifermin/FGF-18 & X & & & X & & X & & & X & & X & & & & & & \\\\\n\\hline PK serum collection \\({ }^{(5)}\\) & & & X & & & & & X & & & X & & & & & & \\\\\n\\hline Biomarker serum collection \\({ }^{(6)}\\) & & & X & & & & & X & & & X & & & & & & \\\\\n\\hline Biomarker urine collection & & & X & & & & & X & & & X & & & & & & \\\\\n\\hline PGt sample collection \\({ }^{(7)}\\) & \\multicolumn{17}{|c|}{One sample is needed. It can be taken at any trial visit.} \\\\\n\\hline Pregnancy test (urine) \\({ }^{(8)}\\) & X & & & & & X & & & & & X & & X & & X & & X \\\\\n\\hline 20-meter walk test & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline Knee X-ray \\({ }^{(9)(10)}\\) & X & & & & & & & & & & X & & X & & X & & X \\\\\n\\hline Target Knee MRI \\({ }^{(10)}\\) & X & & & & & X & & & & & X & & X & & X & & X \\\\\n\\hline Synovial fluid collection \\({ }^{(11)}\\) & X & X & X & & & X & X & X & & & & & & & & & \\\\\n\\hline i.a. injection of IMP & X & X & X & & & X & X & X & & & & & & & & & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 6}\n\\begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|l|l|l|l|l|l|l|}\n\\hline Visit & V12 & V13 & V14 & V15 & V16 & V17 & V18 & V19 & V20 & V21 & V22/ ET & V23 (EF1) & V24 (EF2) & V25 (EF3) & V26 (EF4) & V27 (EF5) & V28 (EF6) \\\\\n\\hline Week \\({ }^{ ( 1 ) }\\) & 52 & 53 & 54 & 55 & 64 & 78 & 79 & 80 & 81 & 90 & 104 & 130 & 156 & 182 & 208 & 234 & 260 \\\\\n\\hline Withdraw of analgesia prior to visit & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline WOMAC & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline PGA & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline KOOS QOL and Symptom Index & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline PGIC & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline NRS in both knees & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline Pain in other joints & X & & & & & X & & & & & X & X & X & X & X & X & X \\\\\n\\hline MOS SF-36 & X & & & & & X & & & & & X & X & X & X & X & X & X \\\\\n\\hline ICOAP & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline AEs & \\multicolumn{17}{|c|}{Continuous} \\\\\n\\hline Concomitant medications & \\multicolumn{17}{|c|}{Continuous} \\\\\n\\hline Surgical procedures (target knee) & \\multicolumn{17}{|c|}{Continuous} \\\\\n\\hline Review of subject diaries & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline Vital signs \\({ }^{(2)}\\) & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline Physical examination \\({ }^{(3)}\\) & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline ECG & X & & & & & & & & & & X & & & & & & \\\\\n\\hline Clinical laboratory specimens \\({ }^{(4)}\\) & X & & & & & X & & & & & X & X & X & X & X & X & X \\\\\n\\hline Antibodies to sprifermin/FGF-18 & X & & & X & & X & & & X & & X & & & & & & \\\\\n\\hline PK serum collection \\({ }^{(5)}\\) & & & X & & & & & X & & & X & & & & & & \\\\\n\\hline Biomarker serum collection \\({ }^{(6)}\\) & & & X & & & & & X & & & X & & & & & & \\\\\n\\hline Biomarker urine collection & & & X & & & & & X & & & X & & & & & & \\\\\n\\hline PGt sample collection \\({ }^{(7)}\\) & \\multicolumn{17}{|c|}{One sample is needed. It can be taken at any trial visit.} \\\\\n\\hline Pregnancy test (urine) \\({ }^{(8)}\\) & X & & & & & X & & & & & X & & X & & X & & X \\\\\n\\hline 20-meter walk test & X & & & & X & X & & & & X & X & X & X & X & X & X & X \\\\\n\\hline Knee X-ray \\({ }^{(9)(10)}\\) & X & & & & & & & & & & X & & X & & X & & X \\\\\n\\hline Target Knee MRI \\({ }^{(10)}\\) & X & & & & & X & & & & & X & & X & & X & & X \\\\\n\\hline Synovial fluid collection \\({ }^{(11)}\\) & X & X & X & & & X & X & X & & & & & & & & & \\\\\n\\hline i.a. injection of IMP & X & X & X & & & X & X & X & & & & & & & & & \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.9103709401097149,"confidence_rate":0.999968830418755},{"cnt":[[244,397],[734,397],[734,1802],[244,1802]],"region":{"top_left_x":244,"top_left_y":397,"width":490,"height":1406},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c876fec7b8a74d64b50c24121cdb7f82","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[790,397],[859,397],[859,1802],[790,1802]],"region":{"top_left_x":790,"top_left_y":397,"width":70,"height":1406},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4f9a6213cd94fffab75cc25c6d5bfea","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[885,397],[950,397],[950,1802],[885,1802]],"region":{"top_left_x":885,"top_left_y":397,"width":66,"height":1406},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28b8f7ec484344568a1fa67057c1e09f","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[979,397],[1046,397],[1046,1802],[979,1802]],"region":{"top_left_x":978,"top_left_y":397,"width":68,"height":1406},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb94864db86d4dbaad8b450f189ad8a1","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1070,397],[1139,397],[1139,1802],[1070,1802]],"region":{"top_left_x":1069,"top_left_y":397,"width":70,"height":1406},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6be0d0e0302a42f7bbd1ce7d2f6dd8d5","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1165,397],[1234,397],[1234,1802],[1165,1802]],"region":{"top_left_x":1164,"top_left_y":397,"width":71,"height":1406},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"022cbcfbed8b42c2b855c516156e13ea","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1256,397],[1329,397],[1329,1802],[1256,1802]],"region":{"top_left_x":1255,"top_left_y":397,"width":75,"height":1406},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f05cb20934ed40b3bb7497ddb6a23d32","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1344,1802],[1347,397],[1420,397],[1417,1803]],"region":{"top_left_x":1343,"top_left_y":396,"width":78,"height":1407},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d09cca8c64e4d8b85afc59d4ac8f634","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1442,397],[1516,397],[1516,1802],[1442,1802]],"region":{"top_left_x":1442,"top_left_y":397,"width":74,"height":1406},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61e2f3adffbd4d7a94ec572461a439fa","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1531,397],[1607,397],[1607,1802],[1531,1802]],"region":{"top_left_x":1530,"top_left_y":397,"width":77,"height":1406},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a371181c1c4f408db76180e07801da2a","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1628,397],[1695,397],[1695,1802],[1628,1802]],"region":{"top_left_x":1628,"top_left_y":397,"width":68,"height":1406},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"806f4474c77c4a97bc8f1fc6721658c9","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1726,397],[1830,397],[1830,1802],[1726,1802]],"region":{"top_left_x":1725,"top_left_y":397,"width":105,"height":1406},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c47f636154642818663cd103eb9d32d","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1853,397],[1953,397],[1953,1802],[1853,1802]],"region":{"top_left_x":1853,"top_left_y":397,"width":101,"height":1406},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d85f2b2e17244d7693eb5d29f219fe12","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[1975,397],[2070,397],[2070,1802],[1975,1802]],"region":{"top_left_x":1974,"top_left_y":397,"width":96,"height":1406},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2acdd21edbf84aa6a0d590f95d8c18cd","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[2087,397],[2185,397],[2185,1802],[2087,1802]],"region":{"top_left_x":2087,"top_left_y":397,"width":98,"height":1406},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8a4758c03654dae9f1adde5393bd9af","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[2204,397],[2300,397],[2300,1802],[2204,1802]],"region":{"top_left_x":2204,"top_left_y":397,"width":96,"height":1406},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fadfdfc67124441698879b1324b2f62f","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[2321,397],[2419,397],[2419,1802],[2321,1802]],"region":{"top_left_x":2321,"top_left_y":397,"width":98,"height":1406},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25d76efdd76e439783c19a6bc94f375d","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[2434,397],[2536,397],[2536,1802],[2434,1802]],"region":{"top_left_x":2433,"top_left_y":397,"width":103,"height":1406},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38133d49ade24e4a9aa7524f60f0ff6d","type":"table_column","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,414],[2549,414],[2549,499],[225,499]],"region":{"top_left_x":225,"top_left_y":414,"width":2324,"height":85},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b390aa494fd5499d844597b22a69125c","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,501],[2549,501],[2549,546],[225,546]],"region":{"top_left_x":225,"top_left_y":500,"width":2324,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa5f69fc4159409db881f5c76befa311","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,549],[2549,549],[2549,596],[225,596]],"region":{"top_left_x":225,"top_left_y":548,"width":2324,"height":49},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab132c3c272347f7a734e65578163145","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,596],[2549,596],[2549,637],[225,637]],"region":{"top_left_x":225,"top_left_y":596,"width":2324,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33dbfc3325a24102b1f04f1cee6de2b5","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,640],[2549,640],[2549,681],[225,681]],"region":{"top_left_x":225,"top_left_y":639,"width":2324,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1119986192046f78a2063b4cbfd7acf","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,683],[2549,683],[2549,728],[225,728]],"region":{"top_left_x":225,"top_left_y":682,"width":2324,"height":47},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7abf13dd50614bb0a09ad352fd3ef13e","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,730],[2549,730],[2549,772],[225,772]],"region":{"top_left_x":225,"top_left_y":730,"width":2324,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"803c19a69dd040c288ede88787ccb262","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,774],[2549,774],[2549,819],[225,819]],"region":{"top_left_x":225,"top_left_y":773,"width":2324,"height":47},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1828bb636d9c41389a56ec0e94d2f978","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,817],[2549,817],[2549,867],[225,867]],"region":{"top_left_x":225,"top_left_y":817,"width":2324,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89d462062d3546b0b67931491bb0d90a","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,860],[2546,860],[2546,908],[225,908]],"region":{"top_left_x":225,"top_left_y":860,"width":2322,"height":49},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fea83c259821438c8ecafbe2c9702f5f","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,906],[2549,906],[2549,954],[225,954]],"region":{"top_left_x":225,"top_left_y":905,"width":2324,"height":49},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"745f27f753c543d7b143d6183eb6d0f9","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,951],[2549,951],[2549,997],[225,997]],"region":{"top_left_x":225,"top_left_y":951,"width":2324,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5958b7b223843b49815db544cf7f2d3","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,997],[2549,997],[2549,1042],[225,1042]],"region":{"top_left_x":225,"top_left_y":996,"width":2324,"height":47},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d5cb2925821425ca1072743f466b0a1","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1042],[2549,1042],[2549,1088],[225,1088]],"region":{"top_left_x":225,"top_left_y":1042,"width":2324,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b915a2d1f1444c18a77f88adcd986824","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1086],[2549,1086],[2549,1131],[225,1131]],"region":{"top_left_x":225,"top_left_y":1085,"width":2324,"height":47},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89378477bfb842e2ba72c9992e7d0617","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1125],[2549,1125],[2549,1179],[225,1179]],"region":{"top_left_x":225,"top_left_y":1124,"width":2324,"height":55},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ddabd1e5fd6e48cba2eac0aa91aea930","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1168],[2549,1168],[2549,1222],[225,1222]],"region":{"top_left_x":225,"top_left_y":1167,"width":2324,"height":56},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7e508c4696244fdb90cad977e9ae870","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1220],[2549,1220],[2549,1261],[225,1261]],"region":{"top_left_x":225,"top_left_y":1219,"width":2324,"height":43},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35843192bd2d4c21bba611e6c7a316cc","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1259],[2549,1259],[2549,1309],[225,1309]],"region":{"top_left_x":225,"top_left_y":1258,"width":2324,"height":51},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50fd9e680cdf48989256ac2f9b6b4405","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1309],[2549,1309],[2549,1354],[225,1354]],"region":{"top_left_x":225,"top_left_y":1308,"width":2324,"height":47},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae2a9814e5a74a34be16c423992d63e0","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1350],[2549,1350],[2549,1397],[225,1397]],"region":{"top_left_x":225,"top_left_y":1349,"width":2324,"height":49},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b2be184e2bd4dbba788335fb44ba6f8","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1393],[2549,1393],[2549,1443],[225,1443]],"region":{"top_left_x":225,"top_left_y":1393,"width":2324,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"228bbd40a2564c8b982779bfc6729490","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1443],[2549,1443],[2549,1486],[225,1486]],"region":{"top_left_x":225,"top_left_y":1442,"width":2324,"height":45},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"074798cd362c4cc0a7083f737ebe644f","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1484],[2549,1484],[2549,1534],[225,1534]],"region":{"top_left_x":225,"top_left_y":1484,"width":2324,"height":50},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8905eb30fa9c4c2ab951e6c2ab4ec2fc","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1527],[2549,1527],[2549,1579],[225,1579]],"region":{"top_left_x":225,"top_left_y":1527,"width":2324,"height":53},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32069f02218d41259d7a73e5422d5eac","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1577],[2549,1577],[2549,1621],[225,1621]],"region":{"top_left_x":225,"top_left_y":1577,"width":2324,"height":44},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d16e7d4e91c4b3aa9c0bbbd5a53a05e","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1614],[2549,1614],[2549,1668],[225,1668]],"region":{"top_left_x":225,"top_left_y":1614,"width":2324,"height":55},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de1a24591de44043960ea48fe13276e8","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1662],[2549,1662],[2549,1711],[225,1711]],"region":{"top_left_x":225,"top_left_y":1661,"width":2324,"height":51},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a70444f9dc241b6aca802dad7e5714a","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1705],[2549,1705],[2549,1757],[225,1757]],"region":{"top_left_x":225,"top_left_y":1704,"width":2324,"height":53},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bebe48239e04d258ebde7e023246dc1","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[225,1757],[2549,1757],[2549,1802],[225,1802]],"region":{"top_left_x":225,"top_left_y":1756,"width":2324,"height":47},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d08da0bb6d9b416cb6cd9458d7702575","type":"table_row","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"","text_display":""},{"cnt":[[247,419],[325,419],[325,453],[247,453]],"region":{"top_left_x":246,"top_left_y":418,"width":79,"height":36},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b04ec1ce13d9469b97f0248e9509bc61","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Visit","text_display":"Visit","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[792,419],[857,419],[857,453],[792,453]],"region":{"top_left_x":792,"top_left_y":418,"width":66,"height":36},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82d65420fcc448448623ab3b70c33d45","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V12","text_display":"V12","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[888,419],[953,419],[953,453],[888,453]],"region":{"top_left_x":887,"top_left_y":418,"width":66,"height":36},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba0ba6c400a1468790c4a96d1785f54b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V13","text_display":"V13","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[981,419],[1046,419],[1046,453],[981,453]],"region":{"top_left_x":980,"top_left_y":418,"width":66,"height":36},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea3670fd3db745278b8f36d4d13505bb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V14","text_display":"V14","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1074,419],[1139,419],[1139,453],[1074,453]],"region":{"top_left_x":1073,"top_left_y":418,"width":66,"height":36},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab177b98b39b48debd8934e4452ce618","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V15","text_display":"V15","cell_row":0,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1165,419],[1234,419],[1234,453],[1165,453]],"region":{"top_left_x":1164,"top_left_y":418,"width":71,"height":36},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48dd6580dfcc41338fdf26ebe28d1a3f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V16","text_display":"V16","cell_row":0,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1260,419],[1325,419],[1325,453],[1260,453]],"region":{"top_left_x":1260,"top_left_y":418,"width":66,"height":36},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e815febe21064b79b541d46b0f93f572","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V17","text_display":"V17","cell_row":0,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1351,419],[1420,419],[1420,453],[1351,453]],"region":{"top_left_x":1351,"top_left_y":418,"width":70,"height":36},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31f7480cbf44446b877cb555a6948977","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V18","text_display":"V18","cell_row":0,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1446,419],[1511,419],[1511,453],[1446,453]],"region":{"top_left_x":1446,"top_left_y":418,"width":66,"height":36},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f78b7fa09a04763b2df3fd1b362217e","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V19","text_display":"V19","cell_row":0,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1537,419],[1604,419],[1604,453],[1537,453]],"region":{"top_left_x":1537,"top_left_y":418,"width":68,"height":36},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4eed35e4125041f29c27f7cc76a4adc0","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V20","text_display":"V20","cell_row":0,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1633,419],[1695,419],[1695,453],[1633,453]],"region":{"top_left_x":1632,"top_left_y":418,"width":64,"height":36},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"545600990986410da4480d879e9a3f5b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"V21","text_display":"V21","cell_row":0,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1741,419],[1821,419],[1821,490],[1741,490]],"region":{"top_left_x":1740,"top_left_y":418,"width":81,"height":73},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bacd20e008a464fb5df35f89117c4bb","type":"complex_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["35b4fd34d41f4b8094eb4d9c959c00fc","3d2992ebe548428584ffa9265eafb947"],"text":"V22/ ET","text_display":"V22/ ET","cell_row":0,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1743,419],[1817,419],[1817,453],[1743,453]],"region":{"top_left_x":1743,"top_left_y":418,"width":74,"height":36},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35b4fd34d41f4b8094eb4d9c959c00fc","type":"text","conversion_output":false,"parent_id":"1bacd20e008a464fb5df35f89117c4bb","text":"V22/","text_display":"V22/","confidence":1,"confidence_rate":1},{"cnt":[[1758,449],[1810,449],[1810,488],[1758,488]],"region":{"top_left_x":1758,"top_left_y":448,"width":53,"height":40},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d2992ebe548428584ffa9265eafb947","type":"text","conversion_output":false,"parent_id":"1bacd20e008a464fb5df35f89117c4bb","text":"ET","text_display":" ET","confidence":1,"confidence_rate":1},{"cnt":[[1862,419],[1949,419],[1949,494],[1862,494]],"region":{"top_left_x":1862,"top_left_y":418,"width":87,"height":77},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2accde30e0d54377ad58189ce92a0bb5","type":"complex_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["fbc2bded13ee41f5ac956d29fe77cc82","99598f635c2e488a8c630278d75f6dc6"],"text":"V23 (EF1)","text_display":"V23 (EF1)","cell_row":0,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1871,421],[1938,421],[1938,453],[1871,453]],"region":{"top_left_x":1870,"top_left_y":420,"width":68,"height":34},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbc2bded13ee41f5ac956d29fe77cc82","type":"text","conversion_output":false,"parent_id":"2accde30e0d54377ad58189ce92a0bb5","text":"V23","text_display":"V23","confidence":1,"confidence_rate":1},{"cnt":[[1864,458],[1947,458],[1947,494],[1864,494]],"region":{"top_left_x":1864,"top_left_y":457,"width":83,"height":38},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99598f635c2e488a8c630278d75f6dc6","type":"text","conversion_output":false,"parent_id":"2accde30e0d54377ad58189ce92a0bb5","text":"(EF1)","text_display":" (EF1)","confidence":1,"confidence_rate":1},{"cnt":[[1979,419],[2064,419],[2064,494],[1979,494]],"region":{"top_left_x":1979,"top_left_y":418,"width":85,"height":77},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab60c27d640c47a7a835e1a2414d6b03","type":"complex_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["53abeb184255467893cd01c0e8784e8b","d6343f612fe44a20a74e012ef367f309"],"text":"V24 (EF2)","text_display":"V24 (EF2)","cell_row":0,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1988,421],[2055,421],[2055,453],[1988,453]],"region":{"top_left_x":1987,"top_left_y":420,"width":68,"height":34},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53abeb184255467893cd01c0e8784e8b","type":"text","conversion_output":false,"parent_id":"ab60c27d640c47a7a835e1a2414d6b03","text":"V24","text_display":"V24","confidence":1,"confidence_rate":1},{"cnt":[[1979,458],[2064,458],[2064,494],[1979,494]],"region":{"top_left_x":1979,"top_left_y":457,"width":85,"height":38},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6343f612fe44a20a74e012ef367f309","type":"text","conversion_output":false,"parent_id":"ab60c27d640c47a7a835e1a2414d6b03","text":"(EF2)","text_display":" (EF2)","confidence":1,"confidence_rate":1},{"cnt":[[2092,419],[2180,419],[2180,494],[2092,494]],"region":{"top_left_x":2091,"top_left_y":418,"width":90,"height":77},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"036fed687b1d429b82e0fa8af9428836","type":"complex_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["25d83c93111b4a438bdaf528899cb365","c2ab0c5bdd154c54904e7586efa4e6e9"],"text":"V25 (EF3)","text_display":"V25 (EF3)","cell_row":0,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2105,421],[2170,421],[2170,453],[2105,453]],"region":{"top_left_x":2104,"top_left_y":420,"width":66,"height":34},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25d83c93111b4a438bdaf528899cb365","type":"text","conversion_output":false,"parent_id":"036fed687b1d429b82e0fa8af9428836","text":"V25","text_display":"V25","confidence":1,"confidence_rate":1},{"cnt":[[2096,458],[2176,458],[2176,494],[2096,494]],"region":{"top_left_x":2095,"top_left_y":457,"width":82,"height":38},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2ab0c5bdd154c54904e7586efa4e6e9","type":"text","conversion_output":false,"parent_id":"036fed687b1d429b82e0fa8af9428836","text":"(EF3)","text_display":" (EF3)","confidence":1,"confidence_rate":1},{"cnt":[[2209,419],[2295,419],[2295,494],[2209,494]],"region":{"top_left_x":2208,"top_left_y":418,"width":88,"height":77},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba3eec6ff0bf402294f96e65faba30bb","type":"complex_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["74297f4fdd5e471f88d898accce072b5","36c477201bbc4e29a7c12fd1b684c363"],"text":"V26 (EF4)","text_display":"V26 (EF4)","cell_row":0,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2222,423],[2287,423],[2287,453],[2222,453]],"region":{"top_left_x":2221,"top_left_y":422,"width":66,"height":32},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74297f4fdd5e471f88d898accce072b5","type":"text","conversion_output":false,"parent_id":"ba3eec6ff0bf402294f96e65faba30bb","text":"V26","text_display":"V26","confidence":1,"confidence_rate":1},{"cnt":[[2213,458],[2293,458],[2293,494],[2213,494]],"region":{"top_left_x":2212,"top_left_y":457,"width":82,"height":38},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36c477201bbc4e29a7c12fd1b684c363","type":"text","conversion_output":false,"parent_id":"ba3eec6ff0bf402294f96e65faba30bb","text":"(EF4)","text_display":" (EF4)","confidence":1,"confidence_rate":1},{"cnt":[[2326,419],[2410,419],[2410,494],[2326,494]],"region":{"top_left_x":2325,"top_left_y":418,"width":85,"height":77},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f03e5c2af209461b916344fbdc620259","type":"complex_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["9b3cf520bbae47598d14a572b136aa6b","33ad0f5cca2543159461f6a3134ab7c9"],"text":"V27 (EF5)","text_display":"V27 (EF5)","cell_row":0,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":0.9970703125,"confidence_rate":0.9998533113880873},{"cnt":[[2334,421],[2399,421],[2399,453],[2334,453]],"region":{"top_left_x":2334,"top_left_y":420,"width":66,"height":34},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b3cf520bbae47598d14a572b136aa6b","type":"text","conversion_output":false,"parent_id":"f03e5c2af209461b916344fbdc620259","text":"V27","text_display":"V27","confidence":1,"confidence_rate":1},{"cnt":[[2326,458],[2410,458],[2410,494],[2326,494]],"region":{"top_left_x":2325,"top_left_y":457,"width":85,"height":38},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33ad0f5cca2543159461f6a3134ab7c9","type":"text","conversion_output":false,"parent_id":"f03e5c2af209461b916344fbdc620259","text":"(EF5)","text_display":" (EF5)","confidence":0.9970703125,"confidence_rate":0.9997066442937235},{"cnt":[[2438,419],[2531,419],[2531,494],[2438,494]],"region":{"top_left_x":2438,"top_left_y":418,"width":94,"height":77},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df92a0b35a734f54b3ce08d94a9553e8","type":"complex_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["7f1ac70c381e43f89c4571e81ff2c6c1","be06ee0c20344be894961b18fed3e072"],"text":"V28 (EF6)","text_display":"V28 (EF6)","cell_row":0,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2451,421],[2516,421],[2516,453],[2451,453]],"region":{"top_left_x":2451,"top_left_y":420,"width":66,"height":34},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f1ac70c381e43f89c4571e81ff2c6c1","type":"text","conversion_output":false,"parent_id":"df92a0b35a734f54b3ce08d94a9553e8","text":"V28","text_display":"V28","confidence":1,"confidence_rate":1},{"cnt":[[2442,458],[2525,458],[2525,494],[2442,494]],"region":{"top_left_x":2442,"top_left_y":457,"width":83,"height":38},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be06ee0c20344be894961b18fed3e072","type":"text","conversion_output":false,"parent_id":"df92a0b35a734f54b3ce08d94a9553e8","text":"(EF6)","text_display":" (EF6)","confidence":1,"confidence_rate":1},{"cnt":[[247,503],[359,503],[359,542],[247,542]],"region":{"top_left_x":246,"top_left_y":503,"width":114,"height":40},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"355bd6acddb448a28ee2807a772441da","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Week \\({ }^{ ( 1 ) }\\)","text_display":"Week \\({ }^{ ( 1 ) }\\)","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9103709401097149,"confidence_rate":0.9966519338851623},{"cnt":[[801,503],[849,503],[849,544],[801,544]],"region":{"top_left_x":801,"top_left_y":503,"width":48,"height":42},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8eb5a9275b684f148564f05fd515a12f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"52","text_display":"52","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[888,503],[940,503],[940,544],[888,544]],"region":{"top_left_x":887,"top_left_y":503,"width":53,"height":42},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"703c70d9e1b949d3b899c80dd33a7b57","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"53","text_display":"53","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[992,503],[1035,503],[1035,544],[992,544]],"region":{"top_left_x":991,"top_left_y":503,"width":44,"height":42},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b0b4a0494b045c1830b9165396bbcf5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"54","text_display":"54","cell_row":1,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1080,503],[1130,503],[1130,544],[1080,544]],"region":{"top_left_x":1080,"top_left_y":503,"width":51,"height":42},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c70e876f93c34e7d98eb9ea3b66739ee","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"55","text_display":"55","cell_row":1,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1178,503],[1221,503],[1221,544],[1178,544]],"region":{"top_left_x":1177,"top_left_y":503,"width":45,"height":42},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d6a64b0217748d3a3eb29b8e151e2f0","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"64","text_display":"64","cell_row":1,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,503],[1314,503],[1314,544],[1271,544]],"region":{"top_left_x":1270,"top_left_y":503,"width":45,"height":42},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6256ef70c6fd4d349d4128916b17a873","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"78","text_display":"78","cell_row":1,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1360,503],[1410,503],[1410,544],[1360,544]],"region":{"top_left_x":1359,"top_left_y":503,"width":51,"height":42},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"645811b4672344dbbee55fdf21a23049","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"79","text_display":"79","cell_row":1,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1459,503],[1500,503],[1500,544],[1459,544]],"region":{"top_left_x":1459,"top_left_y":503,"width":42,"height":42},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec6c03ba25224c58a3bd66654b557824","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"80","text_display":"80","cell_row":1,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1550,503],[1591,503],[1591,544],[1550,544]],"region":{"top_left_x":1550,"top_left_y":503,"width":42,"height":42},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3e60b3fcaa745458ff4c708e243bd5f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"81","text_display":"81","cell_row":1,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1646,503],[1689,503],[1689,544],[1646,544]],"region":{"top_left_x":1645,"top_left_y":503,"width":44,"height":42},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9500a0cb2cf49afa9bdaac4be1de156","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"90","text_display":"90","cell_row":1,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1750,512],[1812,512],[1812,544],[1750,544]],"region":{"top_left_x":1749,"top_left_y":511,"width":64,"height":34},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c84722c7dc24b5fbf08f291d574c17a","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"104","text_display":"104","cell_row":1,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1875,512],[1936,512],[1936,544],[1875,544]],"region":{"top_left_x":1875,"top_left_y":511,"width":61,"height":34},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d930e1eab104af79016a9d794030bf3","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"130","text_display":"130","cell_row":1,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1992,512],[2053,512],[2053,544],[1992,544]],"region":{"top_left_x":1992,"top_left_y":511,"width":61,"height":34},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6cd31aa04eb144628b066d095a2ee641","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"156","text_display":"156","cell_row":1,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2109,510],[2170,510],[2170,544],[2109,544]],"region":{"top_left_x":2108,"top_left_y":509,"width":62,"height":36},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1bd2da77a884651b3780bd9e9172ad9","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"182","text_display":"182","cell_row":1,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2222,512],[2282,512],[2282,544],[2222,544]],"region":{"top_left_x":2221,"top_left_y":511,"width":62,"height":34},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"549305d07cce440990804cc40f3c66d3","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"208","text_display":"208","cell_row":1,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2339,512],[2399,512],[2399,544],[2339,544]],"region":{"top_left_x":2338,"top_left_y":511,"width":62,"height":34},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e84cc9fcae08466193af6a3a7608e122","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"234","text_display":"234","cell_row":1,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2455,512],[2516,512],[2516,544],[2455,544]],"region":{"top_left_x":2455,"top_left_y":511,"width":62,"height":34},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"684e60ef55e642e99a7d469d8960387b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"260","text_display":"260","cell_row":1,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,555],[730,555],[730,594],[247,594]],"region":{"top_left_x":246,"top_left_y":555,"width":484,"height":40},"line":105,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da2d99cb0a48415c942e478da00b4ebf","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Withdraw of analgesia prior to visit","text_display":"Withdraw of analgesia prior to visit","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,555],[842,555],[842,588],[801,588]],"region":{"top_left_x":801,"top_left_y":555,"width":42,"height":33},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a935ca71533f4e39b4f8bb708c643ead","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1184,555],[1219,555],[1219,588],[1184,588]],"region":{"top_left_x":1184,"top_left_y":555,"width":35,"height":33},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"415a90cdde2f4ae0aa8f86430b5c2bd5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,555],[1308,555],[1308,588],[1271,588]],"region":{"top_left_x":1270,"top_left_y":555,"width":38,"height":33},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61b7e90717594f849cb54359db3b90f7","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,555],[1689,555],[1689,588],[1650,588]],"region":{"top_left_x":1649,"top_left_y":555,"width":40,"height":33},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a1a17d4a41e44ffa9a1cc9850e89660","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,555],[1797,555],[1797,588],[1767,588]],"region":{"top_left_x":1766,"top_left_y":555,"width":32,"height":33},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8d5d4bacf704e79919b7df7ea9e28e8","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1892,555],[1923,555],[1923,588],[1892,588]],"region":{"top_left_x":1892,"top_left_y":555,"width":31,"height":33},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1e36decc24f40e1b2b1124b2c894c00","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,555],[2040,555],[2040,588],[2005,588]],"region":{"top_left_x":2005,"top_left_y":555,"width":35,"height":33},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d9f84d6d6dc4788aa61f94119a2ff1f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,555],[2161,555],[2161,588],[2122,588]],"region":{"top_left_x":2121,"top_left_y":555,"width":40,"height":33},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2be2c79acce4be1beaaf4792f0df93c","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,555],[2269,555],[2269,588],[2239,588]],"region":{"top_left_x":2238,"top_left_y":555,"width":32,"height":33},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9a4e3a9cf734b85b0e8de7b3ce2a463","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2356,555],[2388,555],[2388,588],[2356,588]],"region":{"top_left_x":2355,"top_left_y":555,"width":34,"height":33},"line":115,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff98c07dbe1d4358b0b083ca801effe5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2473,555],[2510,555],[2510,588],[2473,588]],"region":{"top_left_x":2472,"top_left_y":555,"width":38,"height":33},"line":116,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02d913d36a1447ad840dd72ac6e3878c","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":2,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,601],[377,601],[377,633],[247,633]],"region":{"top_left_x":246,"top_left_y":600,"width":131,"height":34},"line":117,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c3ee14b13fc414db1a51e520de693a5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"WOMAC","text_display":"WOMAC","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,590],[844,590],[844,635],[801,635]],"region":{"top_left_x":801,"top_left_y":589,"width":44,"height":47},"line":118,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eeb18c66e26645ff9516a65724066a67","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1184,590],[1219,590],[1219,635],[1184,635]],"region":{"top_left_x":1184,"top_left_y":589,"width":35,"height":47},"line":119,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66474c2e972e4e1db4bc1e2c078df450","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,590],[1310,590],[1310,635],[1271,635]],"region":{"top_left_x":1270,"top_left_y":589,"width":40,"height":47},"line":120,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02e6ae7f1acb4cd19ff24ee29b038f32","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,590],[1689,590],[1689,635],[1650,635]],"region":{"top_left_x":1649,"top_left_y":589,"width":40,"height":47},"line":121,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54cdb5c1466b4603a874ea93c9201aeb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,590],[1797,590],[1797,635],[1767,635]],"region":{"top_left_x":1766,"top_left_y":589,"width":32,"height":47},"line":122,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3d4c94660084e39be6401b4f4407e4f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1892,590],[1923,590],[1923,635],[1892,635]],"region":{"top_left_x":1892,"top_left_y":589,"width":31,"height":47},"line":123,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"030de60822504009b718dacd8db10e2a","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,590],[2040,590],[2040,635],[2005,635]],"region":{"top_left_x":2005,"top_left_y":589,"width":35,"height":47},"line":124,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e3d2de616324cf9a2d8b96dde9da44f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,590],[2161,590],[2161,635],[2122,635]],"region":{"top_left_x":2121,"top_left_y":589,"width":40,"height":47},"line":125,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"333e7793cea241aca1b97b1c04c797f6","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,590],[2269,590],[2269,635],[2239,635]],"region":{"top_left_x":2238,"top_left_y":589,"width":32,"height":47},"line":126,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a94f116088f43d794b7edf226ad3501","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,590],[2388,590],[2388,635],[2352,635]],"region":{"top_left_x":2351,"top_left_y":589,"width":38,"height":47},"line":127,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa3bc4695faf495bb2dfde930f34e3b0","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,590],[2510,590],[2510,635],[2468,635]],"region":{"top_left_x":2468,"top_left_y":589,"width":42,"height":47},"line":128,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e49992e767d47b58b36fd0ad5d54118","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":3,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,644],[322,644],[322,679],[247,679]],"region":{"top_left_x":246,"top_left_y":643,"width":77,"height":36},"line":129,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b89781759e1f45a29ccb3bfa0aa87306","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"PGA","text_display":"PGA","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,642],[844,642],[844,679],[801,679]],"region":{"top_left_x":801,"top_left_y":641,"width":44,"height":38},"line":130,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ea29f5d1c0643f3a39c2a3cd37efaed","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1184,642],[1219,642],[1219,679],[1184,679]],"region":{"top_left_x":1184,"top_left_y":641,"width":35,"height":38},"line":131,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00c57534a5c34811a594dcb125f21d17","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,642],[1312,642],[1312,679],[1271,679]],"region":{"top_left_x":1270,"top_left_y":641,"width":43,"height":38},"line":132,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a00a20aa0b784f8d9741a99382fd92c8","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,642],[1689,642],[1689,679],[1650,679]],"region":{"top_left_x":1649,"top_left_y":641,"width":40,"height":38},"line":133,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c770df66b5f4c1a880561064eb3d922","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,642],[1797,642],[1797,679],[1767,679]],"region":{"top_left_x":1766,"top_left_y":641,"width":32,"height":38},"line":134,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5abc5670b2e44734bee49a2d32bb62e9","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1892,642],[1923,642],[1923,679],[1892,679]],"region":{"top_left_x":1892,"top_left_y":641,"width":31,"height":38},"line":135,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"088e2680c1664673be5a23fdd09bbea3","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,642],[2040,642],[2040,679],[2005,679]],"region":{"top_left_x":2005,"top_left_y":641,"width":35,"height":38},"line":136,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0adbb8ab43cf4d7cb879089a0aef0c20","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,642],[2161,642],[2161,679],[2122,679]],"region":{"top_left_x":2121,"top_left_y":641,"width":40,"height":38},"line":137,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d41e21426d3a4dc1b2eaafe03af4d903","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,642],[2269,642],[2269,679],[2239,679]],"region":{"top_left_x":2238,"top_left_y":641,"width":32,"height":38},"line":138,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b35758f14a14628ac76b089f06f6d01","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,642],[2388,642],[2388,679],[2352,679]],"region":{"top_left_x":2351,"top_left_y":641,"width":38,"height":38},"line":139,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fce28f505ec4c0e81a3b0d3935457e7","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,642],[2510,642],[2510,679],[2468,679]],"region":{"top_left_x":2468,"top_left_y":641,"width":42,"height":38},"line":140,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f8844467b39424d839834949a7df700","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":4,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,687],[706,687],[706,728],[247,728]],"region":{"top_left_x":246,"top_left_y":687,"width":460,"height":42},"line":141,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b44f8bc337fc42e085fbc9ad03a0a281","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"KOOS QOL and Symptom Index","text_display":"KOOS QOL and Symptom Index","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,679],[844,679],[844,722],[801,722]],"region":{"top_left_x":801,"top_left_y":678,"width":44,"height":44},"line":142,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7056036b10bc4c5498c35cc0174ed4ea","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1182,679],[1219,679],[1219,724],[1182,724]],"region":{"top_left_x":1182,"top_left_y":678,"width":37,"height":46},"line":143,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bd1858da3d446c681d6e8f95735e42f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,679],[1312,679],[1312,722],[1271,722]],"region":{"top_left_x":1270,"top_left_y":678,"width":43,"height":44},"line":144,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79f2cc736daa4224b962f6c055064e77","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,679],[1689,679],[1689,722],[1650,722]],"region":{"top_left_x":1649,"top_left_y":678,"width":40,"height":44},"line":145,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"954785c7eaa64ca294d2942c5b912a56","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,679],[1797,679],[1797,724],[1767,724]],"region":{"top_left_x":1766,"top_left_y":678,"width":32,"height":46},"line":146,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2cb1f6491d9428c874d7171384aa5c2","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1892,679],[1923,679],[1923,722],[1892,722]],"region":{"top_left_x":1892,"top_left_y":678,"width":31,"height":44},"line":147,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26f905ec9da944a592beac4803c5c7bf","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,679],[2040,679],[2040,722],[2005,722]],"region":{"top_left_x":2005,"top_left_y":678,"width":35,"height":44},"line":148,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34348599ca434c4185b7958923f8953b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,679],[2161,679],[2161,724],[2122,724]],"region":{"top_left_x":2121,"top_left_y":678,"width":40,"height":46},"line":149,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19ee1021d603478980c064b710a630b2","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,679],[2269,679],[2269,722],[2239,722]],"region":{"top_left_x":2238,"top_left_y":678,"width":32,"height":44},"line":150,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc726477876948a088a28bc4fe605a44","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,679],[2388,679],[2388,724],[2352,724]],"region":{"top_left_x":2351,"top_left_y":678,"width":38,"height":46},"line":151,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c975a338de54a72a14633ec6d3ab6e9","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,679],[2510,679],[2510,724],[2468,724]],"region":{"top_left_x":2468,"top_left_y":678,"width":42,"height":46},"line":152,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48681852519f4254b626d3e9ee649724","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":5,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,735],[333,735],[333,769],[247,769]],"region":{"top_left_x":246,"top_left_y":734,"width":88,"height":36},"line":153,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ed45c78544949578f10bc067ef2ab9c","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"PGIC","text_display":"PGIC","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,730],[844,730],[844,769],[801,769]],"region":{"top_left_x":801,"top_left_y":730,"width":44,"height":40},"line":154,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba5b12f01e094edc92155c953af98ace","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1182,730],[1219,730],[1219,769],[1182,769]],"region":{"top_left_x":1182,"top_left_y":730,"width":37,"height":40},"line":155,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21085dbc66124483966430307e9befa2","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,730],[1312,730],[1312,769],[1271,769]],"region":{"top_left_x":1270,"top_left_y":730,"width":43,"height":40},"line":156,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f5159fde41342a8b0d6528d5804a007","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,730],[1689,730],[1689,769],[1650,769]],"region":{"top_left_x":1649,"top_left_y":730,"width":40,"height":40},"line":157,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bce71ce95414f83adaa73690237816d","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,730],[1797,730],[1797,769],[1767,769]],"region":{"top_left_x":1766,"top_left_y":730,"width":32,"height":40},"line":158,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b367fdd74ce4085bf7fbcd4a9659b37","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1892,730],[1923,730],[1923,769],[1892,769]],"region":{"top_left_x":1892,"top_left_y":730,"width":31,"height":40},"line":159,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36a35ee308484ea5a8d0e759c815b96d","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,730],[2040,730],[2040,769],[2005,769]],"region":{"top_left_x":2005,"top_left_y":730,"width":35,"height":40},"line":160,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f2afa96d6bb4dcf8f1a21e5cc5f0689","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,730],[2161,730],[2161,769],[2122,769]],"region":{"top_left_x":2121,"top_left_y":730,"width":40,"height":40},"line":161,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c11d3ca6ef474d76b204ce3f114bc209","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,730],[2269,730],[2269,769],[2239,769]],"region":{"top_left_x":2238,"top_left_y":730,"width":32,"height":40},"line":162,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4f14fab06ec4eb0bdf624088d6b4d9b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,730],[2388,730],[2388,769],[2352,769]],"region":{"top_left_x":2351,"top_left_y":730,"width":38,"height":40},"line":163,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee043d34b5234f60abfb9ceeae4c5f75","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,730],[2510,730],[2510,769],[2468,769]],"region":{"top_left_x":2468,"top_left_y":730,"width":42,"height":40},"line":164,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4be61afe2a0b4c8983288fe49d188575","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":6,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,780],[513,780],[513,815],[247,815]],"region":{"top_left_x":246,"top_left_y":780,"width":268,"height":35},"line":165,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba06507225204f6abad9cd34dc5ff614","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"NRS in both knees","text_display":"NRS in both knees","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,780],[844,780],[844,817],[801,817]],"region":{"top_left_x":801,"top_left_y":780,"width":44,"height":38},"line":166,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d41f9f1e78c47d483cebf82e4ab484e","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1182,778],[1219,778],[1219,817],[1182,817]],"region":{"top_left_x":1182,"top_left_y":778,"width":37,"height":40},"line":167,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1316d347d59548a4822ed2e2fb59013c","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,778],[1312,778],[1312,817],[1271,817]],"region":{"top_left_x":1270,"top_left_y":778,"width":43,"height":40},"line":168,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ad1f2a317fd471cb387eb4947fba92d","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,778],[1689,778],[1689,817],[1650,817]],"region":{"top_left_x":1649,"top_left_y":778,"width":40,"height":40},"line":169,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1ebe23524714b5d8330c6ed312e5ee5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,778],[1797,778],[1797,817],[1767,817]],"region":{"top_left_x":1766,"top_left_y":778,"width":32,"height":40},"line":170,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3d464e6d7e2446f9c94fa20026288c9","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1890,778],[1923,778],[1923,817],[1890,817]],"region":{"top_left_x":1890,"top_left_y":778,"width":33,"height":40},"line":171,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93bd2688e87b4e978d453bb830026a38","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,778],[2040,778],[2040,817],[2005,817]],"region":{"top_left_x":2005,"top_left_y":778,"width":35,"height":40},"line":172,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b6e8b3212744974b1948e0c9241da12","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,778],[2161,778],[2161,817],[2122,817]],"region":{"top_left_x":2121,"top_left_y":778,"width":40,"height":40},"line":173,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88ffb1b7959f4928bf9de0524102bc93","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,778],[2269,778],[2269,817],[2239,817]],"region":{"top_left_x":2238,"top_left_y":778,"width":32,"height":40},"line":174,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2c02d44d8bb4984864ead7b7340fc42","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,778],[2388,778],[2388,817],[2352,817]],"region":{"top_left_x":2351,"top_left_y":778,"width":38,"height":40},"line":175,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e1796e2c458439f96b0422f337fb09c","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,778],[2510,778],[2510,817],[2468,817]],"region":{"top_left_x":2468,"top_left_y":778,"width":42,"height":40},"line":176,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dabd0160a30b4802aa8ffbbfc2a25cda","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":7,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,821],[511,821],[511,863],[247,863]],"region":{"top_left_x":246,"top_left_y":821,"width":265,"height":42},"line":177,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"222fb00e23f14d9ea8247390bb5bcd49","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Pain in other joints","text_display":"Pain in other joints","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,817],[844,817],[844,858],[801,858]],"region":{"top_left_x":801,"top_left_y":817,"width":44,"height":42},"line":178,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5836e5033be34bf0921b2e530c61d54f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,817],[1312,817],[1312,860],[1271,860]],"region":{"top_left_x":1270,"top_left_y":817,"width":43,"height":44},"line":179,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a5651c1c08944d4aef1719f223307bb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":8,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,817],[1797,817],[1797,858],[1767,858]],"region":{"top_left_x":1766,"top_left_y":817,"width":32,"height":42},"line":180,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"feabe358d7e44fd3b1e848f4796e78d6","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":8,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1890,817],[1923,817],[1923,856],[1890,856]],"region":{"top_left_x":1890,"top_left_y":817,"width":33,"height":40},"line":181,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c24e1e7f176449d8959ac8c18d909870","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":8,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,817],[2040,817],[2040,858],[2005,858]],"region":{"top_left_x":2005,"top_left_y":817,"width":35,"height":42},"line":182,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de59f18a7a5e4396ac4aa88163ef9b6a","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":8,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,817],[2161,817],[2161,860],[2122,860]],"region":{"top_left_x":2121,"top_left_y":817,"width":40,"height":44},"line":183,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b75a94da371c4beaa34ef9061beb2a1f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":8,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,817],[2282,817],[2282,860],[2239,860]],"region":{"top_left_x":2238,"top_left_y":817,"width":45,"height":44},"line":184,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02d114db6ac74a488300c6509098dadf","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":8,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,817],[2388,817],[2388,860],[2352,860]],"region":{"top_left_x":2351,"top_left_y":817,"width":38,"height":44},"line":185,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ba04d0d70c04b9ba7b3435f388f563f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":8,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,817],[2510,817],[2510,860],[2468,860]],"region":{"top_left_x":2468,"top_left_y":817,"width":42,"height":44},"line":186,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57a4baf51e9744e7ba913ec8844581c6","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":8,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,869],[418,869],[418,902],[247,902]],"region":{"top_left_x":246,"top_left_y":869,"width":172,"height":33},"line":187,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14b07f1cbc8741cc80d0fed4f1726fe9","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"MOS SF-36","text_display":"MOS SF-36","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,869],[844,869],[844,904],[801,904]],"region":{"top_left_x":801,"top_left_y":869,"width":44,"height":35},"line":188,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f8b0119a717434f9a84d6e355cf780d","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,869],[1312,869],[1312,904],[1271,904]],"region":{"top_left_x":1270,"top_left_y":869,"width":43,"height":35},"line":189,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1337a3b6fb804474b864e7ae4e8524f7","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":9,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,869],[1797,869],[1797,904],[1767,904]],"region":{"top_left_x":1766,"top_left_y":869,"width":32,"height":35},"line":190,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7f3bdd59d8241c5a9bdb2cb7c5ccc9f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":9,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1892,869],[1923,869],[1923,904],[1892,904]],"region":{"top_left_x":1892,"top_left_y":869,"width":31,"height":35},"line":191,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ffe292d61ce445c9234acd077a8f956","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":9,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,869],[2040,869],[2040,904],[2005,904]],"region":{"top_left_x":2005,"top_left_y":869,"width":35,"height":35},"line":192,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83c73350e5f24ca7b68f05a016d302e8","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":9,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,869],[2161,869],[2161,904],[2122,904]],"region":{"top_left_x":2121,"top_left_y":869,"width":40,"height":35},"line":193,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa2d29ead7e84a9ea793277ce3fe7486","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":9,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,869],[2282,869],[2282,904],[2239,904]],"region":{"top_left_x":2238,"top_left_y":869,"width":45,"height":35},"line":194,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76858b6e6a434be5ad1f0dfc6ac08061","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":9,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,869],[2388,869],[2388,904],[2352,904]],"region":{"top_left_x":2351,"top_left_y":869,"width":38,"height":35},"line":195,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea08a5bacbe34bda9dec1908f154b378","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":9,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,869],[2510,869],[2510,904],[2468,904]],"region":{"top_left_x":2468,"top_left_y":869,"width":42,"height":35},"line":196,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6556ca605c8a40e9a742ff020fdec8db","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":9,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,912],[348,912],[348,945],[247,945]],"region":{"top_left_x":246,"top_left_y":912,"width":103,"height":33},"line":197,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ef6f935626a46dfb04dbae9165cfbea","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"ICOAP","text_display":"ICOAP","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,906],[844,906],[844,947],[801,947]],"region":{"top_left_x":801,"top_left_y":905,"width":44,"height":43},"line":198,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec477bb13c7d4ab6b8d05e171d9dfbf2","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1182,906],[1219,906],[1219,947],[1182,947]],"region":{"top_left_x":1182,"top_left_y":905,"width":37,"height":43},"line":199,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"130555bab23548a299e8f0d393208f49","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,906],[1312,906],[1312,947],[1271,947]],"region":{"top_left_x":1270,"top_left_y":905,"width":43,"height":43},"line":200,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80bb52edacec47e980f15fe96dec4895","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,904],[1689,904],[1689,947],[1650,947]],"region":{"top_left_x":1649,"top_left_y":903,"width":40,"height":45},"line":201,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"813245316a9046f78c3f6c9279d021b9","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,906],[1797,906],[1797,947],[1767,947]],"region":{"top_left_x":1766,"top_left_y":905,"width":32,"height":43},"line":202,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d112df749dc1451eb26d28707af2e557","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1890,906],[1923,906],[1923,947],[1890,947]],"region":{"top_left_x":1890,"top_left_y":905,"width":33,"height":43},"line":203,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d468803f935c43099f683cd9c66d7550","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[2005,906],[2040,906],[2040,947],[2005,947]],"region":{"top_left_x":2005,"top_left_y":905,"width":35,"height":43},"line":204,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81e3c8de87e8459288ef9af95a697830","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,906],[2161,906],[2161,947],[2122,947]],"region":{"top_left_x":2121,"top_left_y":905,"width":40,"height":43},"line":205,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0ad9fdd7ca04f0d9ebe2f98d1003d93","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,906],[2282,906],[2282,947],[2239,947]],"region":{"top_left_x":2238,"top_left_y":905,"width":45,"height":43},"line":206,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee86e1e9a4fb4aa7b9d694457f2a89b6","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,906],[2388,906],[2388,947],[2352,947]],"region":{"top_left_x":2351,"top_left_y":905,"width":38,"height":43},"line":207,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f1964effbec43d583916d35af2e0455","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,906],[2510,906],[2510,947],[2468,947]],"region":{"top_left_x":2468,"top_left_y":905,"width":42,"height":43},"line":208,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d095c89082344aa5b104112316d44338","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":10,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[247,956],[316,956],[316,995],[247,995]],"region":{"top_left_x":246,"top_left_y":955,"width":70,"height":40},"line":209,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c8e88316e174541808dfff24764ea20","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"AEs","text_display":"AEs","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[788,954],[2542,954],[2542,997],[788,997]],"region":{"top_left_x":788,"top_left_y":953,"width":1755,"height":44},"line":210,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df747c7af0c6421cb4d6a5d36eedd88b","type":"table_spanning_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["c8caa2a2e63847bca8d42df7f414708a"],"text":"","text_display":"Continuous","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":17},{"cnt":[[1576,956],[1743,956],[1743,993],[1576,993]],"region":{"top_left_x":1576,"top_left_y":955,"width":168,"height":38},"line":211,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8caa2a2e63847bca8d42df7f414708a","type":"simple_cell","conversion_output":false,"parent_id":"df747c7af0c6421cb4d6a5d36eedd88b","text":"Continuous","text_display":"Continuous","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":17,"confidence":1,"confidence_rate":1},{"cnt":[[247,999],[604,999],[604,1036],[247,1036]],"region":{"top_left_x":246,"top_left_y":999,"width":358,"height":37},"line":212,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e07d440b45a041609f00c277d77facf8","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Concomitant medications","text_display":"Concomitant medications","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[788,999],[2542,999],[2542,1040],[788,1040]],"region":{"top_left_x":788,"top_left_y":999,"width":1755,"height":42},"line":213,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b447a3195ed847419b777197aa3c8137","type":"table_spanning_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["17fa5d749f5842bb9a221e9be7e2ffa0"],"text":"","text_display":"Continuous","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":17},{"cnt":[[1576,1003],[1743,1003],[1743,1036],[1576,1036]],"region":{"top_left_x":1576,"top_left_y":1003,"width":168,"height":33},"line":214,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17fa5d749f5842bb9a221e9be7e2ffa0","type":"simple_cell","conversion_output":false,"parent_id":"b447a3195ed847419b777197aa3c8137","text":"Continuous","text_display":"Continuous","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":17,"confidence":1,"confidence_rate":1},{"cnt":[[247,1047],[719,1047],[719,1083],[247,1083]],"region":{"top_left_x":246,"top_left_y":1046,"width":473,"height":38},"line":215,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b678818f967c4670ab70c20a149f4667","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Surgical procedures (target knee)","text_display":"Surgical procedures (target knee)","cell_row":13,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[788,1042],[2542,1042],[2542,1086],[788,1086]],"region":{"top_left_x":788,"top_left_y":1042,"width":1755,"height":44},"line":216,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5a882802308440ca69e8433094427b5","type":"table_spanning_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["b8009770fd95494ea4b118ba0d76debf"],"text":"","text_display":"Continuous","cell_row":13,"cell_column":1,"cell_row_span":1,"cell_col_span":17},{"cnt":[[1576,1047],[1743,1047],[1743,1079],[1576,1079]],"region":{"top_left_x":1576,"top_left_y":1046,"width":168,"height":34},"line":217,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8009770fd95494ea4b118ba0d76debf","type":"simple_cell","conversion_output":false,"parent_id":"e5a882802308440ca69e8433094427b5","text":"Continuous","text_display":"Continuous","cell_row":13,"cell_column":1,"cell_row_span":1,"cell_col_span":17,"confidence":1,"confidence_rate":1},{"cnt":[[247,1090],[600,1090],[600,1129],[247,1129]],"region":{"top_left_x":246,"top_left_y":1089,"width":354,"height":40},"line":218,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bc0d41c80ca4c3a930c547ea0371545","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Review of subject diaries","text_display":"Review of subject diaries","cell_row":14,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1092],[844,1092],[844,1131],[801,1131]],"region":{"top_left_x":801,"top_left_y":1092,"width":44,"height":40},"line":219,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31515d1074b543798d0c1c77f3f47108","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[905,1090],[935,1090],[935,1131],[905,1131]],"region":{"top_left_x":904,"top_left_y":1089,"width":32,"height":43},"line":220,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"191664a79d354704a0db8fc740412d52","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[992,1090],[1031,1090],[1031,1131],[992,1131]],"region":{"top_left_x":991,"top_left_y":1089,"width":40,"height":43},"line":221,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c02e043a0804ce1bdcc744c1e88da89","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1091,1090],[1122,1090],[1122,1131],[1091,1131]],"region":{"top_left_x":1091,"top_left_y":1089,"width":31,"height":43},"line":222,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b128d42877244aba081f9556f5801ad","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1182,1092],[1219,1092],[1219,1131],[1182,1131]],"region":{"top_left_x":1182,"top_left_y":1092,"width":37,"height":40},"line":223,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6091a38e3934b10a9139f7a506ca79a","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1090],[1310,1090],[1310,1131],[1271,1131]],"region":{"top_left_x":1270,"top_left_y":1089,"width":40,"height":43},"line":224,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a4688a9214243d891b311296c3f90f8","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1371,1090],[1403,1090],[1403,1131],[1371,1131]],"region":{"top_left_x":1370,"top_left_y":1089,"width":34,"height":43},"line":225,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"495b0b01dc8142e797f698472c346ed0","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1464,1092],[1498,1092],[1498,1131],[1464,1131]],"region":{"top_left_x":1463,"top_left_y":1092,"width":36,"height":40},"line":226,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10754727412e457698e80512f365bf15","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1550,1090],[1589,1090],[1589,1131],[1550,1131]],"region":{"top_left_x":1550,"top_left_y":1089,"width":40,"height":43},"line":227,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74266df25e354245bf123d3510b6e95b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,1092],[1689,1092],[1689,1131],[1650,1131]],"region":{"top_left_x":1649,"top_left_y":1092,"width":40,"height":40},"line":228,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c251bfa513454e6f86545a01a2eb58be","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,1092],[1797,1092],[1797,1131],[1767,1131]],"region":{"top_left_x":1766,"top_left_y":1092,"width":32,"height":40},"line":229,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ade958fddaf44f084e376e26aec33fb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1892,1092],[1923,1092],[1923,1131],[1892,1131]],"region":{"top_left_x":1892,"top_left_y":1092,"width":31,"height":40},"line":230,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69f955f50a9146ff8c432da958cc4637","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,1092],[2040,1092],[2040,1131],[2005,1131]],"region":{"top_left_x":2005,"top_left_y":1092,"width":35,"height":40},"line":231,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"047942e380454ea2bb0cb4ae41f84b29","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,1092],[2161,1092],[2161,1131],[2122,1131]],"region":{"top_left_x":2121,"top_left_y":1092,"width":40,"height":40},"line":232,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1b97566eed842bea986c6fcc96632be","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,1090],[2269,1090],[2269,1131],[2239,1131]],"region":{"top_left_x":2238,"top_left_y":1089,"width":32,"height":43},"line":233,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c402be80476346c0b47389c5b8c9d24b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,1090],[2388,1090],[2388,1131],[2352,1131]],"region":{"top_left_x":2351,"top_left_y":1089,"width":38,"height":43},"line":234,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"052215ad5c9d4715b09df3ea4d941e0b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,1090],[2510,1090],[2510,1131],[2468,1131]],"region":{"top_left_x":2468,"top_left_y":1089,"width":42,"height":43},"line":235,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"699c5cc5b0b443f39ba5c2ddaa1da3b9","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":14,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1129],[431,1129],[431,1172],[247,1172]],"region":{"top_left_x":246,"top_left_y":1128,"width":185,"height":45},"line":236,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2a64f64c70d49a18bee6f12bef3007c","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Vital signs \\({ }^{(2)}\\)","text_display":"Vital signs \\({ }^{(2)}\\)","cell_row":15,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.97900390625,"confidence_rate":0.9991841927049925},{"cnt":[[801,1133],[844,1133],[844,1172],[801,1172]],"region":{"top_left_x":801,"top_left_y":1133,"width":44,"height":40},"line":237,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a161c1158f645898647a6535c57fde5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[905,1131],[940,1131],[940,1172],[905,1172]],"region":{"top_left_x":904,"top_left_y":1131,"width":36,"height":42},"line":238,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"269351ab4a7a4135836779f1950bfe89","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[992,1131],[1031,1131],[1031,1172],[992,1172]],"region":{"top_left_x":991,"top_left_y":1131,"width":40,"height":42},"line":239,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e2addd519554c39bc1131cc3517d335","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1091,1131],[1124,1131],[1124,1172],[1091,1172]],"region":{"top_left_x":1091,"top_left_y":1131,"width":33,"height":42},"line":240,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"848b7f6774e142e6a8359dbf579fadfc","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1182,1131],[1219,1131],[1219,1172],[1182,1172]],"region":{"top_left_x":1182,"top_left_y":1131,"width":37,"height":42},"line":241,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f06187267fa46749ef50f28b458f9af","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1131],[1312,1131],[1312,1172],[1271,1172]],"region":{"top_left_x":1270,"top_left_y":1131,"width":43,"height":42},"line":242,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1354d08e2a3423fada6cccc12ac4f21","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1371,1131],[1403,1131],[1403,1172],[1371,1172]],"region":{"top_left_x":1370,"top_left_y":1131,"width":34,"height":42},"line":243,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57f75a543b2a4e3d8acca5772869619e","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1464,1131],[1498,1131],[1498,1172],[1464,1172]],"region":{"top_left_x":1463,"top_left_y":1131,"width":36,"height":42},"line":244,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5717f64d33664db08f6d3d2934f744b2","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1550,1131],[1589,1131],[1589,1172],[1550,1172]],"region":{"top_left_x":1550,"top_left_y":1131,"width":40,"height":42},"line":245,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9528863569404e5c82a826ac96d97c75","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,1131],[1689,1131],[1689,1172],[1650,1172]],"region":{"top_left_x":1649,"top_left_y":1131,"width":40,"height":42},"line":246,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff0d36c6d9984b87b86577b5296ec509","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1131],[1797,1131],[1797,1172],[1760,1172]],"region":{"top_left_x":1760,"top_left_y":1131,"width":38,"height":42},"line":247,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e6773cc9024448ca62de6584593f2b7","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1890,1133],[1923,1133],[1923,1172],[1890,1172]],"region":{"top_left_x":1890,"top_left_y":1133,"width":33,"height":40},"line":248,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bdc83e3b9bc4afa87eb1559cb922edc","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,1133],[2040,1133],[2040,1172],[2005,1172]],"region":{"top_left_x":2005,"top_left_y":1133,"width":35,"height":40},"line":249,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1310ded132444d99bc9d76a1dc7e537","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,1133],[2161,1133],[2161,1172],[2122,1172]],"region":{"top_left_x":2121,"top_left_y":1133,"width":40,"height":40},"line":250,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54b2db6a1bc54564b88825994a67667e","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,1131],[2282,1131],[2282,1172],[2239,1172]],"region":{"top_left_x":2238,"top_left_y":1131,"width":45,"height":42},"line":251,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39e8aeb892ea49c6a34a3d1e61ad7bfb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,1131],[2388,1131],[2388,1172],[2352,1172]],"region":{"top_left_x":2351,"top_left_y":1131,"width":38,"height":42},"line":252,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d610d1635f484c7ba0c5f6356ba72ea1","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,1133],[2510,1133],[2510,1172],[2468,1172]],"region":{"top_left_x":2468,"top_left_y":1133,"width":42,"height":40},"line":253,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3faaf8bfb03946f8929fafeffa76ffba","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":15,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1172],[574,1172],[574,1218],[247,1218]],"region":{"top_left_x":246,"top_left_y":1172,"width":328,"height":46},"line":254,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"270c64ab5f344f50b68e3674fcf3f00a","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Physical examination \\({ }^{(3)}\\)","text_display":"Physical examination \\({ }^{(3)}\\)","cell_row":16,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1181],[844,1181],[844,1220],[801,1220]],"region":{"top_left_x":801,"top_left_y":1180,"width":44,"height":40},"line":255,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0f87b65cd08414ca7cc5f76d07c6b9a","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1182,1181],[1219,1181],[1219,1220],[1182,1220]],"region":{"top_left_x":1182,"top_left_y":1180,"width":37,"height":40},"line":256,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be18b9e8c6b9454a884ab7c8feaadb55","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1181],[1312,1181],[1312,1220],[1271,1220]],"region":{"top_left_x":1270,"top_left_y":1180,"width":43,"height":40},"line":257,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f319f2a4a0c145309657fb80918c9841","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,1181],[1689,1181],[1689,1220],[1650,1220]],"region":{"top_left_x":1649,"top_left_y":1180,"width":40,"height":40},"line":258,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c78ca20d20904e8cb5c0fbfaba27a240","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,1181],[1797,1181],[1797,1220],[1767,1220]],"region":{"top_left_x":1766,"top_left_y":1180,"width":32,"height":40},"line":259,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"421b917c375d4a91abbfb9b886294d1a","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1890,1181],[1923,1181],[1923,1220],[1890,1220]],"region":{"top_left_x":1890,"top_left_y":1180,"width":33,"height":40},"line":260,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4417f8d1fbf24f638251b3128cbbb1a6","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,1181],[2040,1181],[2040,1220],[2005,1220]],"region":{"top_left_x":2005,"top_left_y":1180,"width":35,"height":40},"line":261,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4c6363c7a54424fa5732b44ad9cac25","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,1181],[2161,1181],[2161,1220],[2122,1220]],"region":{"top_left_x":2121,"top_left_y":1180,"width":40,"height":40},"line":262,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4acf6993089c4bc5b5fef30abf8fbbe8","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,1181],[2282,1181],[2282,1220],[2239,1220]],"region":{"top_left_x":2238,"top_left_y":1180,"width":45,"height":40},"line":263,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a0030b0968a462bb947c65e2d4861b1","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,1181],[2388,1181],[2388,1220],[2352,1220]],"region":{"top_left_x":2351,"top_left_y":1180,"width":38,"height":40},"line":264,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ec2e0a839a549258d4c3367885bd0e4","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,1181],[2510,1181],[2510,1220],[2468,1220]],"region":{"top_left_x":2468,"top_left_y":1180,"width":42,"height":40},"line":265,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55a7c21eb0f84a2e946b2a1908d648d8","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":16,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9998371733163992},{"cnt":[[247,1224],[325,1224],[325,1259],[247,1259]],"region":{"top_left_x":246,"top_left_y":1224,"width":79,"height":35},"line":266,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15992090d86b489ca80aa20dc76d9fbf","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"ECG","text_display":"ECG","cell_row":17,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1220],[844,1220],[844,1259],[801,1259]],"region":{"top_left_x":801,"top_left_y":1219,"width":44,"height":40},"line":267,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1128201375e249cd8e9d0817736b685b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":17,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1220],[1797,1220],[1797,1259],[1760,1259]],"region":{"top_left_x":1760,"top_left_y":1219,"width":38,"height":40},"line":268,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"227dcae16efd4447a1b4541b91f4290c","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":17,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1259],[686,1259],[686,1307],[247,1307]],"region":{"top_left_x":246,"top_left_y":1258,"width":441,"height":49},"line":269,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce19511917c442af8d07b80f46e16308","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Clinical laboratory specimens \\({ }^{(4)}\\)","text_display":"Clinical laboratory specimens \\({ }^{(4)}\\)","cell_row":18,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1268],[844,1268],[844,1307],[801,1307]],"region":{"top_left_x":801,"top_left_y":1267,"width":44,"height":40},"line":270,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f031f4dfab71467c9399449e5215f172","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":18,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1268],[1312,1268],[1312,1307],[1271,1307]],"region":{"top_left_x":1270,"top_left_y":1267,"width":43,"height":40},"line":271,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d37bb4999f64b7fae656a2d568ffbf5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":18,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1268],[1797,1268],[1797,1307],[1760,1307]],"region":{"top_left_x":1760,"top_left_y":1267,"width":38,"height":40},"line":272,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b03f21a642a34c89b951706604a253f7","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":18,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1890,1268],[1923,1268],[1923,1307],[1890,1307]],"region":{"top_left_x":1890,"top_left_y":1267,"width":33,"height":40},"line":273,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc23b93d82414845af2dacb3de0b11c5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":18,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,1268],[2040,1268],[2040,1307],[2005,1307]],"region":{"top_left_x":2005,"top_left_y":1267,"width":35,"height":40},"line":274,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16aa076a3475447ba021581851c23115","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":18,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,1268],[2161,1268],[2161,1307],[2122,1307]],"region":{"top_left_x":2121,"top_left_y":1267,"width":40,"height":40},"line":275,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39d1ab0dc03f441bbb3823acef4ada3c","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":18,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,1268],[2282,1268],[2282,1307],[2239,1307]],"region":{"top_left_x":2238,"top_left_y":1267,"width":45,"height":40},"line":276,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e966b534b6c49cd95e0781d3a217f03","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":18,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,1268],[2388,1268],[2388,1307],[2352,1307]],"region":{"top_left_x":2351,"top_left_y":1267,"width":38,"height":40},"line":277,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93f4d9c8829d4360bb1447daacef32dc","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":18,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,1268],[2510,1268],[2510,1307],[2468,1307]],"region":{"top_left_x":2468,"top_left_y":1267,"width":42,"height":40},"line":278,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00276ee2230d456b951724bca22a6d01","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":18,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[247,1315],[695,1315],[695,1352],[247,1352]],"region":{"top_left_x":246,"top_left_y":1315,"width":449,"height":37},"line":279,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95fea570a5de4251b063ceb55be35ec4","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Antibodies to sprifermin/FGF-18","text_display":"Antibodies to sprifermin/FGF-18","cell_row":19,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1315],[844,1315],[844,1350],[801,1350]],"region":{"top_left_x":801,"top_left_y":1315,"width":44,"height":35},"line":280,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cd1bf72e7b746ebacb919a4dd3de7b7","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":19,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1091,1315],[1122,1315],[1122,1350],[1091,1350]],"region":{"top_left_x":1091,"top_left_y":1315,"width":31,"height":35},"line":281,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a284c88b780f4ce4939a5e4cc01abde0","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":19,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1315],[1312,1315],[1312,1350],[1271,1350]],"region":{"top_left_x":1270,"top_left_y":1315,"width":43,"height":35},"line":282,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fdd51f4465a3452495b1a6ba6c67f039","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":19,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1550,1315],[1589,1315],[1589,1350],[1550,1350]],"region":{"top_left_x":1550,"top_left_y":1315,"width":40,"height":35},"line":283,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cb313a248b94d2ebdde1bf96ecf8065","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":19,"cell_column":9,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1315],[1797,1315],[1797,1350],[1760,1350]],"region":{"top_left_x":1760,"top_left_y":1315,"width":38,"height":35},"line":284,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfd72496a5ae4c019938fef964d38449","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":19,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1352],[565,1352],[565,1393],[247,1393]],"region":{"top_left_x":246,"top_left_y":1351,"width":319,"height":43},"line":285,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"beba654f290f4506bbac8824a1ecbfeb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"PK serum collection \\({ }^{(5)}\\)","text_display":"PK serum collection \\({ }^{(5)}\\)","cell_row":20,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999856353826395},{"cnt":[[992,1358],[1031,1358],[1031,1395],[992,1395]],"region":{"top_left_x":991,"top_left_y":1358,"width":40,"height":38},"line":286,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37348774b8b248d294ab30f71b923485","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":20,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1464,1358],[1498,1358],[1498,1395],[1464,1395]],"region":{"top_left_x":1463,"top_left_y":1358,"width":36,"height":38},"line":287,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76bda7dc194e4bd59aca0874ab76a461","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":20,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1358],[1797,1358],[1797,1395],[1760,1395]],"region":{"top_left_x":1760,"top_left_y":1358,"width":38,"height":38},"line":288,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49579cd53ca5486eaa326269f4f4b005","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":20,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1393],[660,1393],[660,1439],[247,1439]],"region":{"top_left_x":246,"top_left_y":1393,"width":415,"height":46},"line":289,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8354a692989443b5b0fcd524fae1083f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Biomarker serum collection \\({ }^{(6)}\\)","text_display":"Biomarker serum collection \\({ }^{(6)}\\)","cell_row":21,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[992,1402],[1031,1402],[1031,1445],[992,1445]],"region":{"top_left_x":991,"top_left_y":1401,"width":40,"height":45},"line":290,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5f15985ca8e483fb44b190639e0deff","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":21,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1464,1402],[1498,1402],[1498,1445],[1464,1445]],"region":{"top_left_x":1463,"top_left_y":1401,"width":36,"height":45},"line":291,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"880023b0b2754411b16b6257407eedd3","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":21,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1402],[1797,1402],[1797,1445],[1760,1445]],"region":{"top_left_x":1760,"top_left_y":1401,"width":38,"height":45},"line":292,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4bb7c6ab83344c5b86dd7f9ca4cca28","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":21,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1447],[613,1447],[613,1482],[247,1482]],"region":{"top_left_x":246,"top_left_y":1447,"width":367,"height":35},"line":293,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2720b4e32001401bbf2adfe6a8bcf00d","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Biomarker urine collection","text_display":"Biomarker urine collection","cell_row":22,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[992,1447],[1031,1447],[1031,1484],[992,1484]],"region":{"top_left_x":991,"top_left_y":1447,"width":40,"height":38},"line":294,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f19262b0b684660becf14a3665808d5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":22,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1464,1447],[1498,1447],[1498,1484],[1464,1484]],"region":{"top_left_x":1463,"top_left_y":1447,"width":36,"height":38},"line":295,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4229c1364df240e6b600e1dec6d33631","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":22,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1447],[1797,1447],[1797,1484],[1760,1484]],"region":{"top_left_x":1760,"top_left_y":1447,"width":38,"height":38},"line":296,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ad3ccaca17b44fd95a6cf138f2c42bf","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":22,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1484],[591,1484],[591,1530],[247,1530]],"region":{"top_left_x":246,"top_left_y":1484,"width":345,"height":46},"line":297,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f912e6dd7e5a46cda6586d766e05f2f3","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"PGt sample collection \\({ }^{(7)}\\)","text_display":"PGt sample collection \\({ }^{(7)}\\)","cell_row":23,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[788,1488],[2540,1488],[2540,1534],[788,1534]],"region":{"top_left_x":788,"top_left_y":1488,"width":1752,"height":46},"line":298,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aac18f861b154107afa6987c529a8024","type":"table_spanning_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","children_ids":["0a11852586b34adea56d93b1b95a2c86"],"text":"","text_display":"One sample is needed. It can be taken at any trial visit.","cell_row":23,"cell_column":1,"cell_row_span":1,"cell_col_span":17},{"cnt":[[1277,1493],[2042,1493],[2042,1530],[1277,1530]],"region":{"top_left_x":1277,"top_left_y":1492,"width":765,"height":38},"line":299,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a11852586b34adea56d93b1b95a2c86","type":"simple_cell","conversion_output":false,"parent_id":"aac18f861b154107afa6987c529a8024","text":"One sample is needed. It can be taken at any trial visit.","text_display":"One sample is needed. It can be taken at any trial visit.","cell_row":23,"cell_column":1,"cell_row_span":1,"cell_col_span":17,"confidence":1,"confidence_rate":1},{"cnt":[[247,1532],[595,1532],[595,1577],[247,1577]],"region":{"top_left_x":246,"top_left_y":1531,"width":350,"height":47},"line":300,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e27cd4ebb24454c9a33084ce54600c2","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Pregnancy test (urine) \\({ }^{(8)}\\)","text_display":"Pregnancy test (urine) \\({ }^{(8)}\\)","cell_row":24,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.998046875,"confidence_rate":0.9999471626165977},{"cnt":[[801,1534],[844,1534],[844,1573],[801,1573]],"region":{"top_left_x":801,"top_left_y":1533,"width":44,"height":40},"line":301,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1686edf8fe340c1ba637f3a416c2135","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":24,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1536],[1312,1536],[1312,1573],[1271,1573]],"region":{"top_left_x":1270,"top_left_y":1536,"width":43,"height":37},"line":302,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"677600780e2444499a6eaac7b20913b4","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":24,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1540],[1797,1540],[1797,1575],[1760,1575]],"region":{"top_left_x":1760,"top_left_y":1540,"width":38,"height":36},"line":303,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"845798bfa40747d3b966e7388f543eac","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":24,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,1536],[2040,1536],[2040,1575],[2005,1575]],"region":{"top_left_x":2005,"top_left_y":1536,"width":35,"height":40},"line":304,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84a394774f564455bc68ac2de9e27fd3","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":24,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,1536],[2282,1536],[2282,1575],[2239,1575]],"region":{"top_left_x":2238,"top_left_y":1536,"width":45,"height":40},"line":305,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"151e5c033cd044dabff1797a4c1fc9ad","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":24,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,1536],[2510,1536],[2510,1575],[2468,1575]],"region":{"top_left_x":2468,"top_left_y":1536,"width":42,"height":40},"line":306,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dfdb47f1c494736a706b29ffaae1e84","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":24,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1582],[513,1582],[513,1616],[247,1616]],"region":{"top_left_x":246,"top_left_y":1581,"width":268,"height":36},"line":307,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed29230671ad4e1a842ae25ebcd69ff4","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"20-meter walk test","text_display":"20-meter walk test","cell_row":25,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.98828125,"confidence_rate":0.9994876115005394},{"cnt":[[801,1584],[844,1584],[844,1623],[801,1623]],"region":{"top_left_x":801,"top_left_y":1583,"width":44,"height":40},"line":308,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fcee533b6c2418b8766c91cde9e6683","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1182,1582],[1219,1582],[1219,1623],[1182,1623]],"region":{"top_left_x":1182,"top_left_y":1581,"width":37,"height":42},"line":309,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5bf77b35feb242ce88c01345de41fd75","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1579],[1312,1579],[1312,1623],[1271,1623]],"region":{"top_left_x":1270,"top_left_y":1579,"width":43,"height":44},"line":310,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e3f9569394343748b1af3f8a896f25f","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1650,1582],[1689,1582],[1689,1623],[1650,1623]],"region":{"top_left_x":1649,"top_left_y":1581,"width":40,"height":42},"line":311,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9f2dacb6199470fb83692553c5d6eff","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":10,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1767,1584],[1799,1584],[1799,1623],[1767,1623]],"region":{"top_left_x":1766,"top_left_y":1583,"width":34,"height":40},"line":312,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"183cc98e0af047e5b9ec62b9d5aa0113","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1892,1582],[1923,1582],[1923,1623],[1892,1623]],"region":{"top_left_x":1892,"top_left_y":1581,"width":31,"height":42},"line":313,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06e64192d87748bc875a39389fa53b38","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":12,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,1582],[2040,1582],[2040,1623],[2005,1623]],"region":{"top_left_x":2005,"top_left_y":1581,"width":35,"height":42},"line":314,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c74b93c44d364bdf954f59b4b6a34f25","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2122,1582],[2161,1582],[2161,1623],[2122,1623]],"region":{"top_left_x":2121,"top_left_y":1581,"width":40,"height":42},"line":315,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"716b9dd9cafa4d75b9fd00303f236667","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":14,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,1584],[2282,1584],[2282,1623],[2239,1623]],"region":{"top_left_x":2238,"top_left_y":1583,"width":45,"height":40},"line":316,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"744e9036499d434db21db7ab15ed06ce","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2352,1579],[2388,1579],[2388,1623],[2352,1623]],"region":{"top_left_x":2351,"top_left_y":1579,"width":38,"height":44},"line":317,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f276806fbbe74560a8ddd94baf8265d6","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":16,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2471,1584],[2510,1584],[2510,1623],[2471,1623]],"region":{"top_left_x":2470,"top_left_y":1583,"width":40,"height":40},"line":318,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1694bb7cd27c490895d00cc13f32d3fc","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":25,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1618],[483,1618],[483,1664],[247,1664]],"region":{"top_left_x":246,"top_left_y":1618,"width":237,"height":46},"line":319,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87e250ad29bf489fadcfbcf0114989bb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Knee X-ray \\({ }^{(9)(10)}\\)","text_display":"Knee X-ray \\({ }^{(9)(10)}\\)","cell_row":26,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9169921875,"confidence_rate":0.9970163108883138},{"cnt":[[801,1627],[844,1627],[844,1662],[801,1662]],"region":{"top_left_x":801,"top_left_y":1626,"width":44,"height":36},"line":320,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eab15d460b6b416081032cff9977c2cd","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":26,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1627],[1797,1627],[1797,1662],[1760,1662]],"region":{"top_left_x":1760,"top_left_y":1626,"width":38,"height":36},"line":321,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13ef0fa3648a477b9bfab4729b93252b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":26,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,1627],[2040,1627],[2040,1662],[2005,1662]],"region":{"top_left_x":2005,"top_left_y":1626,"width":35,"height":36},"line":322,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7868e71ff417475f8a905ace0bd72085","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":26,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,1627],[2282,1627],[2282,1662],[2239,1662]],"region":{"top_left_x":2238,"top_left_y":1626,"width":45,"height":36},"line":323,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d180e3a15b04957a35ee05cf9ce65cb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":26,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,1627],[2510,1627],[2510,1662],[2468,1662]],"region":{"top_left_x":2468,"top_left_y":1626,"width":42,"height":36},"line":324,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22d50afca7314de39a2fea6060b2d9bc","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":26,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1666],[539,1666],[539,1709],[247,1709]],"region":{"top_left_x":246,"top_left_y":1665,"width":293,"height":45},"line":325,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7af309a8347542008ce01e8798e04ef7","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Target Knee MRI \\({ }^{(10)}\\)","text_display":"Target Knee MRI \\({ }^{(10)}\\)","cell_row":27,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1675],[844,1675],[844,1709],[801,1709]],"region":{"top_left_x":801,"top_left_y":1674,"width":44,"height":36},"line":326,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0080a8b73e4d4de8bbc14ba404f39c41","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":27,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1672],[1312,1672],[1312,1709],[1271,1709]],"region":{"top_left_x":1270,"top_left_y":1672,"width":43,"height":38},"line":327,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8191fa77cea4817aef4f407ac42c0da","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":27,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1760,1672],[1797,1672],[1797,1709],[1760,1709]],"region":{"top_left_x":1760,"top_left_y":1672,"width":38,"height":38},"line":328,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ac8127b57a349298d6c5f7c106fe07e","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":27,"cell_column":11,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2005,1672],[2040,1672],[2040,1709],[2005,1709]],"region":{"top_left_x":2005,"top_left_y":1672,"width":35,"height":38},"line":329,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d04e8bc30184d13b1f7e9f950217cdb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":27,"cell_column":13,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2239,1672],[2282,1672],[2282,1709],[2239,1709]],"region":{"top_left_x":2238,"top_left_y":1672,"width":45,"height":38},"line":330,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89da0053b9ca4b3aad34ffb2800a8eed","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":27,"cell_column":15,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2468,1672],[2510,1672],[2510,1709],[2468,1709]],"region":{"top_left_x":2468,"top_left_y":1672,"width":42,"height":38},"line":331,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f287f82494f24900a36a7b1e3f6d7ea9","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":27,"cell_column":17,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[247,1709],[626,1709],[626,1755],[247,1755]],"region":{"top_left_x":246,"top_left_y":1709,"width":380,"height":46},"line":332,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a5dd90e11194b3ca797e0f754671ac9","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"Synovial fluid collection \\({ }^{(11)}\\)","text_display":"Synovial fluid collection \\({ }^{(11)}\\)","cell_row":28,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999880878636791},{"cnt":[[801,1718],[844,1718],[844,1761],[801,1761]],"region":{"top_left_x":801,"top_left_y":1717,"width":44,"height":45},"line":333,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98608ed58494404db07a01256b4ba4d3","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":28,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[905,1714],[940,1714],[940,1761],[905,1761]],"region":{"top_left_x":904,"top_left_y":1713,"width":36,"height":49},"line":334,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a940558961b45f6b60d006535dccb16","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":28,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[992,1716],[1031,1716],[1031,1761],[992,1761]],"region":{"top_left_x":991,"top_left_y":1715,"width":40,"height":47},"line":335,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f6a341d6e054928a952d944526d36da","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":28,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1716],[1312,1716],[1312,1761],[1271,1761]],"region":{"top_left_x":1270,"top_left_y":1715,"width":43,"height":47},"line":336,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66779385501f4fdba6f5e20e8d1a173a","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":28,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1371,1718],[1403,1718],[1403,1761],[1371,1761]],"region":{"top_left_x":1370,"top_left_y":1717,"width":34,"height":45},"line":337,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"328234546c1b4bc59f0f04b4d6dd2ce7","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":28,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1464,1716],[1498,1716],[1498,1761],[1464,1761]],"region":{"top_left_x":1463,"top_left_y":1715,"width":36,"height":47},"line":338,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7d21d9a2801458a92ee0c81566606d5","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":28,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[247,1761],[517,1761],[517,1798],[247,1798]],"region":{"top_left_x":246,"top_left_y":1761,"width":272,"height":38},"line":339,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ef0cfc7559f4f2a89aecc592b04ae6c","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"i.a. injection of IMP","text_display":"i.a. injection of IMP","cell_row":29,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1761],[844,1761],[844,1798],[801,1798]],"region":{"top_left_x":801,"top_left_y":1761,"width":44,"height":38},"line":340,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f98710ec043e4b73ab7c13b83cae2e16","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":29,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[905,1761],[940,1761],[940,1798],[905,1798]],"region":{"top_left_x":904,"top_left_y":1761,"width":36,"height":38},"line":341,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e6273f1231842b49af369193bdf538b","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":29,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[992,1761],[1031,1761],[1031,1798],[992,1798]],"region":{"top_left_x":991,"top_left_y":1761,"width":40,"height":38},"line":342,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a30703f615164fa38ceaf7d2016c60cb","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":29,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1271,1761],[1312,1761],[1312,1798],[1271,1798]],"region":{"top_left_x":1270,"top_left_y":1761,"width":43,"height":38},"line":343,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52d19a6c381945e39d7374b4951b0226","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":29,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1373,1761],[1403,1761],[1403,1798],[1373,1798]],"region":{"top_left_x":1372,"top_left_y":1761,"width":32,"height":38},"line":344,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9be5936c8c3347dbbdedf409d468d15a","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":29,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1464,1761],[1498,1761],[1498,1798],[1464,1798]],"region":{"top_left_x":1463,"top_left_y":1761,"width":36,"height":38},"line":345,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8133eaa897004a8f93aa6ad817dc9882","type":"simple_cell","conversion_output":false,"parent_id":"9bacc05cdca6431dbbb049f93dde1579","text":"X","text_display":"X","cell_row":29,"cell_column":8,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,1809],[836,1809],[836,1848],[245,1848]],"region":{"top_left_x":244,"top_left_y":1808,"width":592,"height":40},"line":346,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25e930b33b3a455fbeeabbdce04a5aeb","type":"text","conversion_output":true,"text":"Table footnotes appear on following page.","text_display":"\n\nTable footnotes appear on following page.","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[436,1886],[436,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1886,"width":193,"height":33},"line":347,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7fed897c9aa486e8af40e2c7abbdce8","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[389,1921],[389,1962],[245,1962]],"region":{"top_left_x":244,"top_left_y":1920,"width":145,"height":42},"line":348,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"658f41f00e9a42c78b935aaec376677a","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1964,1904],[2071,1904],[2071,1938],[1964,1938]],"region":{"top_left_x":1963,"top_left_y":1903,"width":109,"height":35},"line":349,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1b43bff66a946528bdf180ff3ad3dd3","type":"page_info","conversion_output":false,"text":"111/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[2419,1873],[2524,1873],[2524,1974],[2419,1974]],"region":{"top_left_x":2419,"top_left_y":1873,"width":106,"height":102},"line":350,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"e8c7264a750e4500900b1e543c4baf04","type":"page_info","conversion_output":false,"text":"M","text_display":"","confidence":0.998046875,"confidence_rate":0.9996742139405065}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-112","page":112,"lines":[{"cnt":[[236,122],[544,122],[544,226],[236,226]],"region":{"top_left_x":236,"top_left_y":122,"width":308,"height":104},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba1fe461908043288e6e77487bd70496","type":"section_header","conversion_output":false,"children_ids":["dc5dda2065de44a49aac1e96adefaf8e","6ac13d4f0dad49c58cb5fe084d426987"],"text":"","text_display":""},{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc5dda2065de44a49aac1e96adefaf8e","type":"text","conversion_output":true,"parent_id":"ba1fe461908043288e6e77487bd70496","text":"Sprifermin","text_display":"\n\n\\section*{Sprifermin","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[535,172],[535,219],[245,219]],"region":{"top_left_x":244,"top_left_y":171,"width":291,"height":49},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ac13d4f0dad49c58cb5fe084d426987","type":"text","conversion_output":true,"parent_id":"ba1fe461908043288e6e77487bd70496","text":"EMR700692_006","text_display":" \\\\ EMR700692_006}","confidence":1,"confidence_rate":1},{"cnt":[[640,125],[1317,125],[1317,174],[640,174]],"region":{"top_left_x":640,"top_left_y":124,"width":677,"height":51},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61e4d6c6dd1e4583b51056be4d63c1dd","type":"section_header","conversion_output":false,"children_ids":["7938120bb0e0459eb6ab62cfeab8bedd"],"text":"","text_display":""},{"cnt":[[645,129],[1317,129],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":128,"width":673,"height":47},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7938120bb0e0459eb6ab62cfeab8bedd","type":"text","conversion_output":true,"parent_id":"61e4d6c6dd1e4583b51056be4d63c1dd","text":"Phase II Trial of Sprifermin in Knee OA","text_display":"\n\n\\section*{Phase II Trial of Sprifermin in Knee OA}","confidence":1,"confidence_rate":1},{"cnt":[[245,277],[2464,277],[2464,320],[245,320]],"region":{"top_left_x":244,"top_left_y":277,"width":2221,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ef2ff5b6e26424ead79dbd856d86880","type":"text","conversion_output":true,"text":"Abbreviations: AEs: adverse events; ECG: electrocardiogram; i.a: intra-articular; ICOAP: Measure of Intermittent and Constant Osteoarthritis Pain; KOOS: Knee","text_display":"\n\nAbbreviations: AEs: adverse events; ECG: electrocardiogram; i.a: intra-articular; ICOAP: Measure of Intermittent and Constant Osteoarthritis Pain; KOOS: Knee","confidence":1,"confidence_rate":1},{"cnt":[[245,316],[2400,316],[2400,354],[245,354]],"region":{"top_left_x":244,"top_left_y":315,"width":2156,"height":40},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da39de19f3224e5c871a77e83c9cc7a3","type":"text","conversion_output":true,"text":"Injury and Osteoarthritis Outcome Score; MRI: magnetic resonance imaging; NRS: numerical rating scale; PGIC: Patient Global Impression of Change; PK:","text_display":" Injury and Osteoarthritis Outcome Score; MRI: magnetic resonance imaging; NRS: numerical rating scale; PGIC: Patient Global Impression of Change; PK:","confidence":0.9975595474243164,"confidence_rate":0.9999841336626645},{"cnt":[[245,352],[1803,352],[1803,391],[245,391]],"region":{"top_left_x":244,"top_left_y":352,"width":1559,"height":40},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1deeff4a01c47fca28c77a45dbd643e","type":"text","conversion_output":true,"text":"pharmacokinetic; QOL: quality of life; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index","text_display":" pharmacokinetic; QOL: quality of life; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index","confidence":1,"confidence_rate":1},{"cnt":[[245,391],[2484,391],[2484,436],[245,436]],"region":{"top_left_x":244,"top_left_y":391,"width":2240,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8f8751e08dc441f9208b4a8cc82e54d","type":"text","conversion_output":true,"text":"ET: Early Termination (procedures shown for this visit should be performed at the time of early treatment discontinuation or trial withdrawal.) EF: Extended follow-","text_display":"\nET: Early Termination (procedures shown for this visit should be performed at the time of early treatment discontinuation or trial withdrawal.) EF: Extended follow","confidence":0.99951171875,"confidence_rate":0.9999971100604},{"cnt":[[245,434],[299,434],[299,473],[245,473]],"region":{"top_left_x":244,"top_left_y":433,"width":55,"height":40},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"562c70ce47b9489dbf4a2a942833f4bd","type":"text","conversion_output":true,"text":"up.","text_display":"up.","confidence":1,"confidence_rate":1},{"cnt":[[245,486],[2314,486],[2314,526],[245,526]],"region":{"top_left_x":244,"top_left_y":485,"width":2070,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79f654b4cae54ac797b116f7f9545672","type":"text","conversion_output":true,"text":"Subjects will be requested to discontinue the intake of any pain medications for at least 5 half-lives before a visit involving completion of the WOMAC.","text_display":"\nSubjects will be requested to discontinue the intake of any pain medications for at least 5 half-lives before a visit involving completion of the WOMAC.","confidence":1,"confidence_rate":1},{"cnt":[[245,541],[2486,541],[2486,584],[245,584]],"region":{"top_left_x":244,"top_left_y":541,"width":2242,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffd4a728b37c439d85f2b3c148aa33a2","type":"text","conversion_output":true,"text":"At visits where IMP is administered, all procedures should be performed before dosing unless otherwise specified. Subject questionnaires (WOMAC, PGA, KOOS","text_display":"\nAt visits where IMP is administered, all procedures should be performed before dosing unless otherwise specified. Subject questionnaires (WOMAC, PGA, KOOS","confidence":1,"confidence_rate":1},{"cnt":[[245,580],[2417,580],[2417,621],[245,621]],"region":{"top_left_x":244,"top_left_y":580,"width":2173,"height":41},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b941cedf19b8452484c6cf83ba417d19","type":"text","conversion_output":true,"text":"QOL, KOOS Symptom Index, PGIC, NRS in both knees, pain in other joints, MOS SF-36, and ICOAP) should be completed before any other procedures are","text_display":" QOL, KOOS Symptom Index, PGIC, NRS in both knees, pain in other joints, MOS SF-36, and ICOAP) should be completed before any other procedures are","confidence":1,"confidence_rate":1},{"cnt":[[245,614],[956,614],[956,655],[245,655]],"region":{"top_left_x":244,"top_left_y":614,"width":713,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b11025b63b341599576cdc95c9ddf33","type":"text","conversion_output":true,"text":"performed; the WOMAC should be completed first.","text_display":" performed; the WOMAC should be completed first.","confidence":1,"confidence_rate":1},{"cnt":[[245,670],[1962,670],[1962,715],[245,715]],"region":{"top_left_x":244,"top_left_y":670,"width":1718,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b98c5faa29a84311bbabe696c317ab30","type":"text","conversion_output":true,"text":"At each visit, subjects will be given trial diaries which will be collected and reviewed at the following visit (see Section 7.1.1).","text_display":"\n\nAt each visit, subjects will be given trial diaries which will be collected and reviewed at the following visit (see Section 7.1.1).","confidence":0.9819650650024414,"confidence_rate":0.9998671654173499},{"cnt":[[245,726],[2507,726],[2507,769],[245,769]],"region":{"top_left_x":244,"top_left_y":726,"width":2264,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9dea8f5651274412955dcc227de2bef6","type":"text","conversion_output":true,"text":"1. Study visits, beginning with Visit 3, should be planned for the study day specified in the protocol. If it is not possible to complete the visit on the planned day, or if","text_display":"\n1. Study visits, beginning with Visit 3, should be planned for the study day specified in the protocol. If it is not possible to complete the visit on the planned day, or if","confidence":0.8337223529815674,"confidence_rate":0.99897886529669},{"cnt":[[245,765],[2383,765],[2383,806],[245,806]],"region":{"top_left_x":244,"top_left_y":764,"width":2139,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fa7f214d6b24a9090a3eccc462d8b20","type":"text","conversion_output":true,"text":"an emergency occurs, the protocol does allow for some exceptions as long as the minimum and maximum between injection and between treatment cycle","text_display":" an emergency occurs, the protocol does allow for some exceptions as long as the minimum and maximum between injection and between treatment cycle","confidence":1,"confidence_rate":1},{"cnt":[[245,801],[1038,801],[1038,840],[245,840]],"region":{"top_left_x":244,"top_left_y":801,"width":794,"height":40},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b769f0520f734b0f9b3f9b3c035855f6","type":"text","conversion_output":true,"text":"restrictions are maintained. See Section 7.1.1 for details.","text_display":" restrictions are maintained. See Section 7.1.1 for details.","confidence":0.99951171875,"confidence_rate":0.999992368771335},{"cnt":[[245,855],[1369,855],[1369,900],[245,900]],"region":{"top_left_x":244,"top_left_y":855,"width":1125,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fa66bbb10194f98976cc4da8b7026ff","type":"text","conversion_output":true,"text":"2. Sitting systolic and diastolic blood pressure, heart rate, and body temperature.","text_display":"\n2. Sitting systolic and diastolic blood pressure, heart rate, and body temperature.","confidence":1,"confidence_rate":1},{"cnt":[[245,913],[2477,913],[2477,956],[245,956]],"region":{"top_left_x":244,"top_left_y":913,"width":2234,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ee1515cb4584d7f983128967c3e575b","type":"text","conversion_output":true,"text":"3. Including weight every six months (Weeks 78 and 104; Visits 17 and 22 in the treatment phase and all visits is the extended follow-up phase) and height at the","text_display":"\n3. Including weight every six months (Weeks 78 and 104; Visits 17 and 22 in the treatment phase and all visits is the extended follow-up phase) and height at the","confidence":0.9282920191762969,"confidence_rate":0.9995748965543167},{"cnt":[[245,950],[1579,950],[1579,990],[245,990]],"region":{"top_left_x":244,"top_left_y":949,"width":1336,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee5c3afa8ac649a6bb5195f4ca38cfe1","type":"text","conversion_output":true,"text":"end of the DBPC phase (Week 104/Visit 22/Early Termination) and last extended follow-up visit.","text_display":" end of the DBPC phase (Week 104/Visit 22/Early Termination) and last extended follow-up visit.","confidence":1,"confidence_rate":1},{"cnt":[[245,1005],[2348,1005],[2348,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1005,"width":2105,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44fc845fa3c048df9451fc8a2a97d239","type":"text","conversion_output":true,"text":"4. Hematology, biochemistry, urinalysis. See Appendix B for complete list. Coagulation tests will be performed locally at the screening assessment only.","text_display":"\n4. Hematology, biochemistry, urinalysis. See Appendix B for complete list. Coagulation tests will be performed locally at the screening assessment only.","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1343,1061],[1343,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1061,"width":1099,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2dad5c35c954a369be2a9b5df2b178f","type":"text","conversion_output":true,"text":"5. Blood samples for PK will be taken 2 hours after the last dose of each cycle.","text_display":"\n5. Blood samples for PK will be taken 2 hours after the last dose of each cycle.","confidence":1,"confidence_rate":1},{"cnt":[[245,1119],[840,1119],[840,1162],[245,1162]],"region":{"top_left_x":244,"top_left_y":1119,"width":597,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"702cba57053d43fd955f41149aceba5a","type":"text","conversion_output":true,"text":"6. Fasting samples for biomarker analysis.","text_display":"\n6. Fasting samples for biomarker analysis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1098,1177],[1098,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1177,"width":854,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2448bc12d1e1494a844ac9165e60cf83","type":"text","conversion_output":true,"text":"7. PGt samples will be collected for consenting subjects only.","text_display":"\n7. PGt samples will be collected for consenting subjects only.","confidence":1,"confidence_rate":1},{"cnt":[[245,1233],[1699,1233],[1699,1276],[245,1276]],"region":{"top_left_x":244,"top_left_y":1233,"width":1456,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"867ac3f594c341dcb252bfb02662415f","type":"text","conversion_output":true,"text":"8. Urine pregnancy test at scheduled time points (prior to IMP injection) and prior to each X-ray and MRI.","text_display":"\n8. Urine pregnancy test at scheduled time points (prior to IMP injection) and prior to each X-ray and MRI.","confidence":1,"confidence_rate":1},{"cnt":[[245,1289],[2486,1289],[2486,1332],[245,1332]],"region":{"top_left_x":244,"top_left_y":1289,"width":2242,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acc9366f4f4041b98b822a4652c45790","type":"text","conversion_output":true,"text":"9. X-rays of both the target and the contralateral knee will be taken during screening, at Week 104/Visit 22, and at the last EF visits; X-rays of only the target knee","text_display":"\n9. X-rays of both the target and the contralateral knee will be taken during screening, at Week 104/Visit 22, and at the last EF visits; X-rays of only the target knee","confidence":0.99951171875,"confidence_rate":0.9999971604662518},{"cnt":[[245,1328],[2189,1328],[2189,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1327,"width":1946,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a693402151344c6a1c2916895c16394","type":"text","conversion_output":true,"text":"will be taken at other time points. During screening, a long-axis view of the target knee will be taken in addition to the anterior/posterior view.","text_display":" will be taken at other time points. During screening, a long-axis view of the target knee will be taken in addition to the anterior/posterior view.","confidence":1,"confidence_rate":1},{"cnt":[[247,1384],[2477,1384],[2477,1424],[247,1424]],"region":{"top_left_x":247,"top_left_y":1383,"width":2231,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"027150d4206440cead966593fdf3ce96","type":"text","conversion_output":true,"text":"10. At time points where IMP administration is scheduled, X-rays and MRIs may be performed up to 3 days before the planned day of IMP administration. At time","text_display":"\n10. At time points where IMP administration is scheduled, X-rays and MRIs may be performed up to 3 days before the planned day of IMP administration. At time","confidence":0.99951171875,"confidence_rate":0.9999970400013619},{"cnt":[[245,1418],[2486,1418],[2486,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1417,"width":2242,"height":47},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c07a40b564946b8a128a9c0b8420408","type":"text","conversion_output":true,"text":"points where there is no IMP administration scheduled, X-rays and MRIs may be performed within \\(\\pm 4\\) days (DBPC treatment phase) or \\(\\pm 7\\) days (extended follow-","text_display":" points where there is no IMP administration scheduled, X-rays and MRIs may be performed within \\(\\pm 4\\) days (DBPC treatment phase) or \\(\\pm 7\\) days (extended follow","confidence":0.44667021045461297,"confidence_rate":0.9951274565669606},{"cnt":[[245,1457],[668,1457],[668,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1456,"width":425,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4878e450a08d4608abe17a8d86beb377","type":"text","conversion_output":true,"text":"up phase) of the planned day.","text_display":"up phase) of the planned day.","confidence":1,"confidence_rate":1},{"cnt":[[247,1512],[2464,1512],[2464,1553],[247,1553]],"region":{"top_left_x":247,"top_left_y":1512,"width":2218,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5dc37591bd34f9abfcb87a31dc46611","type":"text","conversion_output":true,"text":"11. At visits where IMP is injected, synovial fluid will be collected as part of the i.a. injection procedure, using the same needle that will be used for IMP injection.","text_display":"\n11. At visits where IMP is injected, synovial fluid will be collected as part of the i.a. injection procedure, using the same needle that will be used for IMP injection.","confidence":1,"confidence_rate":1},{"cnt":[[245,1547],[2503,1547],[2503,1590],[245,1590]],"region":{"top_left_x":244,"top_left_y":1546,"width":2259,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4337ad5907742798bee11653182503a","type":"text","conversion_output":true,"text":"PK will be analyzed in synovial fluid at all indicated sampling time points. If the volume of synovial fluid collected permits, biomarkers will also be analyzed at Week","text_display":" PK will be analyzed in synovial fluid at all indicated sampling time points. If the volume of synovial fluid collected permits, biomarkers will also be analyzed at Week","confidence":1,"confidence_rate":1},{"cnt":[[245,1583],[408,1583],[408,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1583,"width":165,"height":40},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90689455dec441d596b419dbdbbf2d07","type":"text","conversion_output":true,"text":"52/Visit 12.","text_display":" 52/Visit 12.","confidence":0.9965834617614746,"confidence_rate":0.9997861236290067},{"cnt":[[245,1886],[440,1886],[440,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1886,"width":197,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"954efde5e17a4712b6700f9c6b722afc","type":"page_info","conversion_output":false,"text":"Document No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[389,1921],[389,1962],[245,1962]],"region":{"top_left_x":244,"top_left_y":1920,"width":145,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e130c24860444c2da3a179a338711056","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1964,1904],[2071,1904],[2071,1938],[1964,1938]],"region":{"top_left_x":1963,"top_left_y":1903,"width":109,"height":35},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf75c611a13044f5aeecec7206fc5309","type":"page_info","conversion_output":false,"text":"112/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[2419,1876],[2524,1876],[2524,1974],[2419,1974]],"region":{"top_left_x":2419,"top_left_y":1875,"width":106,"height":100},"line":38,"column":0,"font_size":111,"is_printed":true,"is_handwritten":false,"id":"98a547ea431549c7834246493661ac1f","type":"page_info","conversion_output":false,"text":"","text_display":""}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"4e250b08-e53f-493a-a5fb-415f48c7d3b1-113","page":113,"lines":[{"cnt":[[245,129],[436,129],[436,174],[245,174]],"region":{"top_left_x":244,"top_left_y":128,"width":193,"height":47},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9ec58e45a274da1b52f5994212c40bb","type":"page_info","conversion_output":false,"text":"Sprifermin","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[645,125],[1317,125],[1317,174],[645,174]],"region":{"top_left_x":644,"top_left_y":124,"width":673,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f768f750f23941cb8591658cc6bc49fd","type":"page_info","conversion_output":false,"text":"Phase II Trial of Sprifermin in Knee OA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,172],[537,172],[537,217],[245,217]],"region":{"top_left_x":244,"top_left_y":171,"width":294,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d80892ea1254800b6e74c1e107f57f1","type":"page_info","conversion_output":false,"text":"EMR700692_006","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[236,314],[1025,314],[1025,389],[236,389]],"region":{"top_left_x":236,"top_left_y":313,"width":789,"height":76},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53181573a8cb4dcfa76488271b7bd891","type":"section_header","conversion_output":false,"children_ids":["a8985ad5b87946b18a904c97e56d6716"],"text":"","text_display":""},{"cnt":[[243,322],[1021,322],[1021,385],[243,385]],"region":{"top_left_x":242,"top_left_y":322,"width":779,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8985ad5b87946b18a904c97e56d6716","type":"text","conversion_output":true,"parent_id":"53181573a8cb4dcfa76488271b7bd891","text":"Appendix F: Pain in Other Joints","text_display":"\n\n\\section*{Appendix F: Pain in Other Joints}","confidence":1,"confidence_rate":1},{"cnt":[[339,468],[1835,468],[1835,1558],[339,1558]],"region":{"top_left_x":339,"top_left_y":468,"width":1496,"height":1090},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80d28a8932b14c2c9e09b3d5bf76f571","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/4e250b08-e53f-493a-a5fb-415f48c7d3b1-113.jpg?height=1090&width=1496&top_left_y=468&top_left_x=339)"},{"cnt":[[245,2509],[507,2509],[507,2546],[245,2546]],"region":{"top_left_x":244,"top_left_y":2509,"width":264,"height":37},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18722fce7d1e4c56a5e26659438c2859","type":"page_info","conversion_output":false,"text":"Document No. CCl","text_display":"","confidence":0.788988676504232,"confidence_rate":0.9887775746426547},{"cnt":[[244,2546],[389,2543],[389,2585],[245,2587]],"region":{"top_left_x":244,"top_left_y":2543,"width":146,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c83da1a34854199baa2a2269cbc80dc","type":"page_info","conversion_output":false,"text":"Object No.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1491,2527],[1601,2527],[1601,2563],[1491,2563]],"region":{"top_left_x":1491,"top_left_y":2526,"width":110,"height":38},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33b8f796c58144a28cec61afe0113e7c","type":"page_info","conversion_output":false,"text":"113/113","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1796,2501],[1897,2501],[1897,2597],[1796,2597]],"region":{"top_left_x":1796,"top_left_y":2500,"width":102,"height":98},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"886c39a7ae614c40b7c67284b12c3ce5","type":"page_info","conversion_output":false,"text":"\\(9 \\sqrt{1}\\)","text_display":"","confidence":0.761138916015625,"confidence_rate":0.9617590360560466}],"page_height":2750,"page_width":2125,"languages_detected":[]}]}