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Identifying nutritional deficiencies at baseline (the first strategy) and monitoring weight loss throughout the intervention period (the second strategy) will be sufficient for addressing participants' nutritional status. \\\\\nIn the event that a weight measurement is not obtained at the last PT intervention visit, the participant's weight at the 16-week follow-up assessment will be compared to his or her baseline weight and, if there has been weight loss of \\(5 \\%\\) or more, the clinical site principal investigator or clinical site clinician will review the participant's weight trajectory, baseline body mass index, baseline MNA®-SF score, and registered dietician's documentation and, if warranted based on clinical judgment, will refer the participant to a dietician or medical provider for follow-up of possible poor nutritional status.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version (date) & Section & Brief Summary of Modification \\\\\n\\hline Version 12.0 (10/19/16) & 9.2, 10.4.9, 11.2, 12.1.8, Table 2 & \\begin{tabular}{l}\nPrior to Version 12.0 of the protocol, three strategies were used to address participants' nutritional status: 1) Consultation with a study registered dietician (RD) at baseline for participants who are malnourished (Mini Nutritional Assessment-Short Form (MNA \\({ }^{( R )-\\text { SF }) \\text { score } \\leq 7 \\text { ), at risk for }}\\) malnutrition (MNA \\({ }^{\\circledR}\\)-SF score 8-11), or with serum albumin \\(\\leq 3.5 g / dl\\); 2) Consultation with a study RD if there is weight loss of \\(2 \\%\\) or more between weight assessments performed every four weeks in the course of the intervention visits, and 3) Referral for follow-up and/or medical evaluation for possible malnutrition if the MNA®-SF score at follow-up is \\(\\leq 7\\). \\\\\nIn Version 12.0, to streamline procedures, we eliminated the third strategy (MNA screening for malnutrition at follow-up). Identifying nutritional deficiencies at baseline (the first strategy) and monitoring weight loss throughout the intervention period (the second strategy) will be sufficient for addressing participants' nutritional status. \\\\\nIn the event that a weight measurement is not obtained at the last PT intervention visit, the participant's weight at the 16-week follow-up assessment will be compared to his or her baseline weight and, if there has been weight loss of \\(5 \\%\\) or more, the clinical site principal investigator or clinical site clinician will review the participant's weight trajectory, baseline body mass index, baseline MNA®-SF score, and registered dietician's documentation and, if warranted based on clinical judgment, will refer the participant to a dietician or medical provider for follow-up of possible poor nutritional status.\n\\end{tabular} 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Identifying nutritional deficiencies at baseline (the first strategy) and monitoring weight loss throughout the intervention period (the second strategy) will be sufficient for addressing participants' nutritional status. \\\\\nIn the event that a weight measurement is not obtained at the last PT intervention visit, the participant's weight at the 16-week follow-up assessment will be compared to his or her baseline weight and, if there has been weight loss of \\(5 \\%\\) or more, the clinical site principal investigator or clinical site clinician will review the participant's weight trajectory, baseline body mass index, baseline MNA®-SF score, and registered dietician's documentation and, if warranted based on clinical judgment, will refer the participant to a dietician or medical provider for follow-up of possible poor nutritional status.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nPrior to Version 12.0 of the protocol, three strategies were used to address participants' nutritional status: 1) Consultation with a study registered dietician (RD) at baseline for participants who are malnourished (Mini Nutritional Assessment-Short Form (MNA \\({ }^{( R )-\\text { SF }) \\text { score } \\leq 7 \\text { ), at risk for }}\\) malnutrition (MNA \\({ }^{\\circledR}\\)-SF score 8-11), or with serum albumin \\(\\leq 3.5 g / dl\\); 2) Consultation with a study RD if there is weight loss of \\(2 \\%\\) or more between weight assessments performed every four weeks in the course of the intervention visits, and 3) Referral for follow-up and/or medical evaluation for possible malnutrition if the MNA®-SF score at follow-up is \\(\\leq 7\\). \\\\\nIn Version 12.0, to streamline procedures, we eliminated the third strategy (MNA screening for malnutrition at follow-up). 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Identifying nutritional","text_display":" (MNA screening for malnutrition at follow-up). Identifying nutritional","confidence":1,"confidence_rate":1},{"cnt":[[899,1078],[1876,1078],[1876,1119],[899,1119]],"region":{"top_left_x":899,"top_left_y":1078,"width":977,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43411bd44cf444acacc6b25cb9aef96d","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"deficiencies at baseline (the first strategy) and monitoring weight loss","text_display":" deficiencies at baseline (the first strategy) and monitoring weight loss","confidence":1,"confidence_rate":1},{"cnt":[[899,1117],[1980,1117],[1980,1158],[899,1158]],"region":{"top_left_x":899,"top_left_y":1116,"width":1081,"height":43},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7433f2a19a5249ac8d06bbe837c167e2","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"throughout the intervention period (the second strategy) will be sufficient for","text_display":" throughout the intervention period (the second strategy) will be sufficient for","confidence":1,"confidence_rate":1},{"cnt":[[899,1158],[1486,1158],[1486,1201],[899,1201]],"region":{"top_left_x":899,"top_left_y":1158,"width":588,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2380ce82418c44af8f88c9e16d1c93fb","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"addressing participants' nutritional status.","text_display":" addressing participants' nutritional status.","confidence":0.98974609375,"confidence_rate":0.9997896784531803},{"cnt":[[899,1238],[1859,1238],[1859,1279],[899,1279]],"region":{"top_left_x":899,"top_left_y":1238,"width":960,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6aab5eca423c47099fede82c464f47a0","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"In the event that a weight measurement is not obtained at the last PT","text_display":"\nIn the event that a weight measurement is not obtained at the last PT","confidence":0.99951171875,"confidence_rate":0.9999934000150488},{"cnt":[[899,1277],[1850,1277],[1850,1318],[899,1318]],"region":{"top_left_x":899,"top_left_y":1277,"width":951,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ee3a2422cd24d798fb4c2ecb10bb4e4","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"intervention visit, the participant's weight at the 16-week follow-up","text_display":" intervention visit, the participant's weight at the 16-week follow-up","confidence":0.99951171875,"confidence_rate":0.9999934000150488},{"cnt":[[899,1316],[1945,1316],[1945,1357],[899,1357]],"region":{"top_left_x":899,"top_left_y":1316,"width":1047,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"503c67dc7f524b3498942e5b4e4cda98","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"assessment will be compared to his or her baseline weight and, if there has","text_display":" assessment will be compared to his or her baseline weight and, if there has","confidence":1,"confidence_rate":1},{"cnt":[[899,1357],[1921,1357],[1921,1401],[899,1401]],"region":{"top_left_x":899,"top_left_y":1357,"width":1023,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08fa4568671c486790d311b972110214","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"been weight loss of \\(5 \\%\\) or more, the clinical site principal investigator or","text_display":" been weight loss of \\(5 \\%\\) or more, the clinical site principal investigator or","confidence":0.979110156185925,"confidence_rate":0.9997456814565571},{"cnt":[[899,1399],[1971,1399],[1971,1440],[899,1440]],"region":{"top_left_x":899,"top_left_y":1398,"width":1073,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dfe80b9fcde4393a82fafb16b2556a2","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"clinical site clinician will review the participant's weight trajectory, baseline","text_display":" clinical site clinician will review the participant's weight trajectory, baseline","confidence":1,"confidence_rate":1},{"cnt":[[899,1437],[1887,1437],[1887,1479],[899,1479]],"region":{"top_left_x":899,"top_left_y":1437,"width":988,"height":42},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d69fccf2d15e464d9bf86b60d76c3191","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"body mass index, baseline MNA®-SF score, and registered dietician's","text_display":" body mass index, baseline MNA®-SF score, and registered dietician's","confidence":0.5740156173706055,"confidence_rate":0.9923199397162012},{"cnt":[[899,1476],[1937,1476],[1937,1518],[899,1518]],"region":{"top_left_x":899,"top_left_y":1476,"width":1038,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2f7e4bd4ce043ae931409c541bc6ce5","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"documentation and, if warranted based on clinical judgment, will refer the","text_display":" documentation and, if warranted based on clinical judgment, will refer the","confidence":1,"confidence_rate":1},{"cnt":[[899,1518],[1958,1518],[1958,1561],[899,1561]],"region":{"top_left_x":899,"top_left_y":1517,"width":1060,"height":44},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09f227a04bbf46da9275f18050ab58bc","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"participant to a dietician or medical provider for follow-up of possible poor","text_display":" participant to a dietician or medical provider for follow-up of possible poor","confidence":1,"confidence_rate":1},{"cnt":[[899,1559],[1148,1559],[1148,1593],[899,1593]],"region":{"top_left_x":899,"top_left_y":1558,"width":250,"height":36},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f22fdb121284c389f02571bafca4528","type":"text","conversion_output":false,"parent_id":"0512f248706f4dba92795d0eddd7efa2","text":"nutritional status.","text_display":" nutritional 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11.0}","confidence":0.9863345623016357,"confidence_rate":0.9998115291429476},{"cnt":[[125,1755],[2000,1755],[2000,2391],[125,2391]],"region":{"top_left_x":124,"top_left_y":1755,"width":1877,"height":637},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed606f44b661422a8002ffcdc215504f","type":"table","conversion_output":true,"children_ids":["a918eca451cb401997a69d0604b22caa","b717a42d885642cbb3b98716ad17bddb","07468251873743f59a79d2faa36e42bc","582d34a01d3a412fac38fcbe113bc415","7ff8db5cdf424465b2b79bc1f59947fc","4b57391773a24c408d5f22f72f07a240","bc53305c4e4142cc85a65ff02e843d23","beba7acbe6b44cafa61f42c77118ac32","b00064cc365b4f6e9fa519374688040d","5c4cbeaa092e4b3699de2d7e57de7d93","5217596924284ad6a23a32234acc2ad7","cf4e65d9ecd64837b58915c0cbf4d792","7dddce1c11a5451b99d462a337ea2c48","15e9fa0bf065479484e2afdc0e9df383","ff6474e3983943be93b3c79bc5c2317f","7993a27883c8469a9314cd63ee0b4140","c8a42f586b0b493c9169a65cacdb231c","015ac175d46a4da0b55577ae4bccc12b","9320206e70b046d990505828ce3be79b"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Version (date) & Section & Brief Summary of Modification \\\\\n\\hline Version 11.0 (8/26/16) & 1, 6.1, 8.1, 10, 11 & In order to conserve resources, we eliminated several secondary and tertiary outcome measures, while retaining measures needed for the assessment and adjudication of the primary outcome, to determine study eligibility, to ensure participant safety, to monitor adverse events, and to describe characteristics of the participant population. \\\\\n\\hline Version 11.0 (8/26/16) & 9.2, 10.6.1, 11.3 & In order to conserve resources, we eliminated the collection of information on use of study-provided dietary supplements. However, procedures for drug accountability will remain unchanged. \\\\\n\\hline Version 11.0 (8/26/16) & 15.6.2 & We expect that, by the time all the approvals for the change described above have been obtained, approximately 160 participants will have been randomized under the existing protocol. The power calculations have been revised accordingly for the secondary and tertiary outcome measures that will no longer be collected. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version (date) & Section & Brief Summary of Modification \\\\\n\\hline Version 11.0 (8/26/16) & 1, 6.1, 8.1, 10, 11 & In order to conserve resources, we eliminated several secondary and tertiary outcome measures, while retaining measures needed for the assessment and adjudication of the primary outcome, to determine study eligibility, to ensure participant safety, to monitor adverse events, and to describe characteristics of the participant population. \\\\\n\\hline Version 11.0 (8/26/16) & 9.2, 10.6.1, 11.3 & In order to conserve resources, we eliminated the collection of information on use of study-provided dietary supplements. However, procedures for drug accountability will remain unchanged. \\\\\n\\hline Version 11.0 (8/26/16) & 15.6.2 & We expect that, by the time all the approvals for the change described above have been obtained, approximately 160 participants will have been randomized under the existing protocol. 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The power calculations have been","confidence":1,"confidence_rate":1},{"cnt":[[899,2305],[1924,2305],[1924,2346],[899,2346]],"region":{"top_left_x":899,"top_left_y":2305,"width":1025,"height":42},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"717f887a89dd43b29ff32d959c3634c4","type":"text","conversion_output":false,"parent_id":"9320206e70b046d990505828ce3be79b","text":"revised accordingly for the secondary and tertiary outcome measures that","text_display":" revised accordingly for the secondary and tertiary outcome measures that","confidence":1,"confidence_rate":1},{"cnt":[[899,2344],[1283,2344],[1283,2385],[899,2385]],"region":{"top_left_x":899,"top_left_y":2344,"width":384,"height":42},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a3a273a7aef4e25807c9b59dae12aa6","type":"text","conversion_output":false,"parent_id":"9320206e70b046d990505828ce3be79b","text":"will no longer be collected.","text_display":" will no longer be collected.","confidence":1,"confidence_rate":1},{"cnt":[[507,2426],[1618,2426],[1618,2481],[507,2481]],"region":{"top_left_x":507,"top_left_y":2425,"width":1111,"height":57},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"747cf35159d045818226a8b66a92c21b","type":"section_header","conversion_output":false,"children_ids":["7d71d32e72f94d509718a982bb22046e"],"text":"","text_display":""},{"cnt":[[511,2432],[1613,2432],[1613,2477],[511,2477]],"region":{"top_left_x":511,"top_left_y":2432,"width":1103,"height":46},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d71d32e72f94d509718a982bb22046e","type":"text","conversion_output":true,"parent_id":"747cf35159d045818226a8b66a92c21b","text":"Summary of Modifications to Protocol Version 9.0 for Version 10.0","text_display":"\n\n\\section*{Summary of Modifications to Protocol Version 9.0 for Version 10.0}","confidence":0.9975605006329715,"confidence_rate":0.9999660772449207},{"cnt":[[127,2501],[2000,2501],[2000,2608],[127,2608]],"region":{"top_left_x":126,"top_left_y":2500,"width":1875,"height":109},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f096dd9b0d247118cc1fc795ed421e8","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\begin{tabular}{l} \nVersion \\\\\n(date)\n\\end{tabular} & Section & Brief Summary of Modification \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\begin{tabular}{l} \nVersion \\\\\n(date)\n\\end{tabular} & Section & Brief Summary of Modification \\\\\n\\hline\n\\end{tabular}","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-002","page":2,"lines":[{"cnt":[[125,168],[2002,168],[2002,1068],[125,1068]],"region":{"top_left_x":124,"top_left_y":167,"width":1879,"height":901},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd3a3737d48744bda15a1c560ceca843","type":"table","conversion_output":true,"children_ids":["75cc6ab8d95749548be28dfaac91a585","cd58d63ed9b24ccd9daa68d76a969205","2af3bbd5d517466eb8d9f16d6feae4b2","7cb799c3f48945be9dde29f29dfad34a","531aedbd15754914bdfdb7b42850975d","18f850605e40456387c0f546f3469cdd","04190d549c6349c8b3862a91308d1334","2f0ace9f8a0f4d9aa2c235df64ec83f1","7c60984e9d3b4a7bad20c2a610d2c995","228b01943a564334b5430e62cb537926","2fc915cda3804c17b98bad1b44ba089b","acecba934bcf48c98d25d115cb7cab72","e2672ae9a5254ef59d2f973890dd82f8","5278b11d5f1e412d83246de91d990fe5","960fded8bf26461198979971c254af08","3366e064a1b24116a457787c888a995c","27ef2395879b495e958d966d4a23a8c7","8d056f3860474101bee3755d51ac8e0e","9c28a237565e443ebd251bb69b014b20"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Version 10.0 (6/7/16) & All sections & Prior to Version 10.0 of the protocol, follow-up assessment visits occurred 16 weeks and 40 weeks from the date of randomization, telephone interviews were conducted every four weeks during the 40-week study period for a total of 10 telephone interviews, and participants received vitamin D, calcium, and multivitamin supplements for a total of 40 weeks. In order to conserve resources and preserve the primary outcome, the protocol was revised so that study participation of participants randomized after approval of Version 10.0 of the protocol will end after the 16-week followup assessment. The wording of the protocol has been changed accordingly. \\\\\n\\hline Version 10.0 (6/7/16) & 15.6.2 & We expect that, by the time all the approvals for the change described above have been obtained, approximately 150 participants will have been randomized under the existing protocol which includes follow-up to 40 weeks post-randomization. The power calculations for some of the outcome variables have been revised accordingly. \\\\\n\\hline Version 10.0 (6/7/16) & 16.7 & We changed \"Monthly reports\" to \"Regular reports\" in the section on study performance monitoring. This was done to accommodate a revised schedule of reports to the Steering Committee. \\\\\n\\hline Version 10.0 (6/7/16) & 20 & Updates were made to the Study Team Roster. Dr. Anne Kenny is leaving the study and was removed from the study team roster. Dr. Yazeed Maghaydah will take her place as the clinical site clinician for the University of Connecticut Health Center clinical site. We also updated contact information for Dr. Ram Miller. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version 10.0 (6/7/16) & All sections & Prior to Version 10.0 of the protocol, follow-up assessment visits occurred 16 weeks and 40 weeks from the date of randomization, telephone interviews were conducted every four weeks during the 40-week study period for a total of 10 telephone interviews, and participants received vitamin D, calcium, and multivitamin supplements for a total of 40 weeks. In order to conserve resources and preserve the primary outcome, the protocol was revised so that study participation of participants randomized after approval of Version 10.0 of the protocol will end after the 16-week followup assessment. The wording of the protocol has been changed accordingly. \\\\\n\\hline Version 10.0 (6/7/16) & 15.6.2 & We expect that, by the time all the approvals for the change described above have been obtained, approximately 150 participants will have been randomized under the existing protocol which includes follow-up to 40 weeks post-randomization. The power calculations for some of the outcome variables have been revised accordingly. \\\\\n\\hline Version 10.0 (6/7/16) & 16.7 & We changed \"Monthly reports\" to \"Regular reports\" in the section on study performance monitoring. This was done to accommodate a revised schedule of reports to the Steering Committee. \\\\\n\\hline Version 10.0 (6/7/16) & 20 & Updates were made to the Study Team Roster. Dr. Anne Kenny is leaving the study and was removed from the study team roster. Dr. Yazeed Maghaydah will take her place as the clinical site clinician for the University of Connecticut Health Center clinical site. 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for a total of 10 telephone interviews, and participants received vitamin D, calcium, and multivitamin supplements for a total of 40 weeks. In order to conserve resources and preserve the primary outcome, the protocol was revised so that study participation of participants randomized after approval of Version 10.0 of the protocol will end after the 16-week followup assessment. The wording of the protocol has been changed accordingly.","text_display":"Prior to Version 10.0 of the protocol, follow-up assessment visits occurred 16 weeks and 40 weeks from the date of randomization, telephone interviews were conducted every four weeks during the 40-week study period for a total of 10 telephone interviews, and participants received vitamin D, calcium, and multivitamin supplements for a total of 40 weeks. In order to conserve resources and preserve the primary outcome, the protocol was revised so that study participation of participants randomized after approval of Version 10.0 of the protocol will end after the 16-week followup assessment. 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The power calculations for some of the outcome variables have been revised accordingly.","text_display":"We expect that, by the time all the approvals for the change described above have been obtained, approximately 150 participants will have been randomized under the existing protocol which includes follow-up to 40 weeks post-randomization. The power calculations for some of the outcome variables have been revised accordingly.","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,542],[1967,542],[1967,581],[899,581]],"region":{"top_left_x":899,"top_left_y":541,"width":1068,"height":40},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"513f8275a8a24467b9ae80ebcfa783c1","type":"text","conversion_output":false,"parent_id":"e2672ae9a5254ef59d2f973890dd82f8","text":"We expect that, by the time all the approvals for the change described above","text_display":"We expect that, by the time all the approvals for the change described above","confidence":1,"confidence_rate":1},{"cnt":[[899,578],[1837,578],[1837,620],[899,620]],"region":{"top_left_x":899,"top_left_y":578,"width":938,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db0c5773f32f43b08c2152bfd55941c3","type":"text","conversion_output":false,"parent_id":"e2672ae9a5254ef59d2f973890dd82f8","text":"have been obtained, approximately 150 participants will have been","text_display":" have been obtained, approximately 150 participants will have been","confidence":1,"confidence_rate":1},{"cnt":[[899,620],[1898,620],[1898,661],[899,661]],"region":{"top_left_x":899,"top_left_y":619,"width":999,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f2e2af9c9ba4a8cb0bb97d72f3c04ef","type":"text","conversion_output":false,"parent_id":"e2672ae9a5254ef59d2f973890dd82f8","text":"randomized under the existing protocol which includes follow-up to 40","text_display":" randomized under the existing protocol which includes follow-up to 40","confidence":1,"confidence_rate":1},{"cnt":[[899,661],[1963,661],[1963,700],[899,700]],"region":{"top_left_x":899,"top_left_y":660,"width":1064,"height":40},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20baca1ea6054cdaa637ef1753d64aae","type":"text","conversion_output":false,"parent_id":"e2672ae9a5254ef59d2f973890dd82f8","text":"weeks post-randomization. The power calculations for some of the outcome","text_display":" weeks post-randomization. The power calculations for some of the outcome","confidence":1,"confidence_rate":1},{"cnt":[[899,700],[1469,700],[1469,741],[899,741]],"region":{"top_left_x":899,"top_left_y":699,"width":570,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"490884b10ec649069ef65a40f103b1df","type":"text","conversion_output":false,"parent_id":"e2672ae9a5254ef59d2f973890dd82f8","text":"variables have been revised accordingly.","text_display":" variables have been revised accordingly.","confidence":1,"confidence_rate":1},{"cnt":[[146,739],[334,739],[334,821],[146,821]],"region":{"top_left_x":145,"top_left_y":738,"width":190,"height":83},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5278b11d5f1e412d83246de91d990fe5","type":"complex_cell","conversion_output":false,"parent_id":"fd3a3737d48744bda15a1c560ceca843","children_ids":["b9a89970badf4e56852aea66af882153","fd58f1408d2d4459b8dfb67a2a700fc0"],"text":"Version 10.0 (6/7/16)","text_display":"Version 10.0 (6/7/16)","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[150,743],[334,743],[334,776],[150,776]],"region":{"top_left_x":149,"top_left_y":743,"width":186,"height":33},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9a89970badf4e56852aea66af882153","type":"text","conversion_output":false,"parent_id":"5278b11d5f1e412d83246de91d990fe5","text":"Version 10.0","text_display":"Version 10.0","confidence":1,"confidence_rate":1},{"cnt":[[150,782],[265,782],[265,819],[150,819]],"region":{"top_left_x":149,"top_left_y":781,"width":116,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd58f1408d2d4459b8dfb67a2a700fc0","type":"text","conversion_output":false,"parent_id":"5278b11d5f1e412d83246de91d990fe5","text":"(6/7/16)","text_display":" (6/7/16)","confidence":1,"confidence_rate":1},{"cnt":[[401,743],[470,743],[470,778],[401,778]],"region":{"top_left_x":401,"top_left_y":743,"width":70,"height":35},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"960fded8bf26461198979971c254af08","type":"simple_cell","conversion_output":false,"parent_id":"fd3a3737d48744bda15a1c560ceca843","text":"16.7","text_display":"16.7","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,741],[1967,741],[1967,862],[899,862]],"region":{"top_left_x":899,"top_left_y":740,"width":1068,"height":123},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3366e064a1b24116a457787c888a995c","type":"complex_cell","conversion_output":false,"parent_id":"fd3a3737d48744bda15a1c560ceca843","children_ids":["9bb1d8d7feff4462a405f23298ad0db4","6f135b333852473db8b1e7bc05a7c9f5","b812e9e4288b46f08c696fe3b6dde922"],"text":"We changed \"Monthly reports\" to \"Regular reports\" in the section on study performance monitoring. This was done to accommodate a revised schedule of reports to the Steering Committee.","text_display":"We changed \"Monthly reports\" to \"Regular reports\" in the section on study performance monitoring. This was done to accommodate a revised schedule of reports to the Steering Committee.","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,743],[1954,743],[1954,780],[899,780]],"region":{"top_left_x":899,"top_left_y":743,"width":1055,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bb1d8d7feff4462a405f23298ad0db4","type":"text","conversion_output":false,"parent_id":"3366e064a1b24116a457787c888a995c","text":"We changed \"Monthly reports\" to \"Regular reports\" in the section on study","text_display":"We changed \"Monthly reports\" to \"Regular reports\" in the section on study","confidence":1,"confidence_rate":1},{"cnt":[[899,782],[1963,782],[1963,821],[899,821]],"region":{"top_left_x":899,"top_left_y":781,"width":1064,"height":40},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f135b333852473db8b1e7bc05a7c9f5","type":"text","conversion_output":false,"parent_id":"3366e064a1b24116a457787c888a995c","text":"performance monitoring. This was done to accommodate a revised schedule","text_display":" performance monitoring. This was done to accommodate a revised schedule","confidence":1,"confidence_rate":1},{"cnt":[[899,821],[1421,821],[1421,862],[899,862]],"region":{"top_left_x":899,"top_left_y":820,"width":523,"height":43},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b812e9e4288b46f08c696fe3b6dde922","type":"text","conversion_output":false,"parent_id":"3366e064a1b24116a457787c888a995c","text":"of reports to the Steering Committee.","text_display":" of reports to the Steering Committee.","confidence":1,"confidence_rate":1},{"cnt":[[146,862],[334,862],[334,944],[146,944]],"region":{"top_left_x":145,"top_left_y":862,"width":190,"height":83},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27ef2395879b495e958d966d4a23a8c7","type":"complex_cell","conversion_output":false,"parent_id":"fd3a3737d48744bda15a1c560ceca843","children_ids":["c6ba3c8a329749deac5762ae175a8c66","0d76ef8adc764d65840451254dc2843c"],"text":"Version 10.0 (6/7/16)","text_display":"Version 10.0 (6/7/16)","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[150,864],[334,864],[334,897],[150,897]],"region":{"top_left_x":149,"top_left_y":864,"width":186,"height":33},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6ba3c8a329749deac5762ae175a8c66","type":"text","conversion_output":false,"parent_id":"27ef2395879b495e958d966d4a23a8c7","text":"Version 10.0","text_display":"Version 10.0","confidence":1,"confidence_rate":1},{"cnt":[[150,903],[265,903],[265,942],[150,942]],"region":{"top_left_x":149,"top_left_y":903,"width":116,"height":40},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d76ef8adc764d65840451254dc2843c","type":"text","conversion_output":false,"parent_id":"27ef2395879b495e958d966d4a23a8c7","text":"(6/7/16)","text_display":" (6/7/16)","confidence":1,"confidence_rate":1},{"cnt":[[401,864],[444,864],[444,905],[401,905]],"region":{"top_left_x":401,"top_left_y":864,"width":44,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d056f3860474101bee3755d51ac8e0e","type":"simple_cell","conversion_output":false,"parent_id":"fd3a3737d48744bda15a1c560ceca843","text":"20","text_display":"20","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[897,862],[1982,862],[1982,1061],[897,1061]],"region":{"top_left_x":897,"top_left_y":862,"width":1085,"height":200},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c28a237565e443ebd251bb69b014b20","type":"complex_cell","conversion_output":false,"parent_id":"fd3a3737d48744bda15a1c560ceca843","children_ids":["4531e56387c44534acd6567dadc7e520","82c09a0ef4344d4e847df641f7142cf3","d3bc945e00714a2d99901085c8592b41","57c1410418b946158b7304521e2bd309","6008ed6cef95424f8896bd4ad6c3a00f"],"text":"Updates were made to the Study Team Roster. Dr. Anne Kenny is leaving the study and was removed from the study team roster. Dr. Yazeed Maghaydah will take her place as the clinical site clinician for the University of Connecticut Health Center clinical site. We also updated contact information for Dr. Ram Miller.","text_display":"Updates were made to the Study Team Roster. Dr. Anne Kenny is leaving the study and was removed from the study team roster. Dr. Yazeed Maghaydah will take her place as the clinical site clinician for the University of Connecticut Health Center clinical site. We also updated contact information for Dr. Ram Miller.","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,864],[1937,864],[1937,903],[899,903]],"region":{"top_left_x":899,"top_left_y":864,"width":1038,"height":40},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4531e56387c44534acd6567dadc7e520","type":"text","conversion_output":false,"parent_id":"9c28a237565e443ebd251bb69b014b20","text":"Updates were made to the Study Team Roster. Dr. Anne Kenny is leaving","text_display":"Updates were made to the Study Team Roster. Dr. Anne Kenny is leaving","confidence":1,"confidence_rate":1},{"cnt":[[899,903],[1837,903],[1837,944],[899,944]],"region":{"top_left_x":899,"top_left_y":903,"width":938,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82c09a0ef4344d4e847df641f7142cf3","type":"text","conversion_output":false,"parent_id":"9c28a237565e443ebd251bb69b014b20","text":"the study and was removed from the study team roster. Dr. Yazeed","text_display":" the study and was removed from the study team roster. Dr. Yazeed","confidence":1,"confidence_rate":1},{"cnt":[[899,942],[1975,942],[1975,983],[899,983]],"region":{"top_left_x":899,"top_left_y":942,"width":1077,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3bc945e00714a2d99901085c8592b41","type":"text","conversion_output":false,"parent_id":"9c28a237565e443ebd251bb69b014b20","text":"Maghaydah will take her place as the clinical site clinician for the University","text_display":" Maghaydah will take her place as the clinical site clinician for the University","confidence":1,"confidence_rate":1},{"cnt":[[899,983],[1841,983],[1841,1022],[899,1022]],"region":{"top_left_x":899,"top_left_y":983,"width":943,"height":40},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57c1410418b946158b7304521e2bd309","type":"text","conversion_output":false,"parent_id":"9c28a237565e443ebd251bb69b014b20","text":"of Connecticut Health Center clinical site. We also updated contact","text_display":" of Connecticut Health Center clinical site. We also updated contact","confidence":1,"confidence_rate":1},{"cnt":[[899,1022],[1352,1022],[1352,1057],[899,1057]],"region":{"top_left_x":899,"top_left_y":1022,"width":453,"height":36},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6008ed6cef95424f8896bd4ad6c3a00f","type":"text","conversion_output":false,"parent_id":"9c28a237565e443ebd251bb69b014b20","text":"information for Dr. Ram Miller.","text_display":" information for Dr. Ram Miller.","confidence":1,"confidence_rate":1},{"cnt":[[511,1102],[1611,1102],[1611,1162],[511,1162]],"region":{"top_left_x":511,"top_left_y":1102,"width":1101,"height":61},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce3fd69f62d4403789ea36ee8cdc2372","type":"section_header","conversion_output":false,"children_ids":["2edd0193a0a84fb59c47645489bbeed4"],"text":"","text_display":""},{"cnt":[[520,1109],[1605,1109],[1605,1154],[520,1154]],"region":{"top_left_x":519,"top_left_y":1108,"width":1086,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2edd0193a0a84fb59c47645489bbeed4","type":"text","conversion_output":true,"parent_id":"ce3fd69f62d4403789ea36ee8cdc2372","text":"Summary of Modifications to Protocol Version 8.0 for Version 9.0","text_display":"\n\n\\section*{Summary of Modifications to Protocol Version 8.0 for Version 9.0}","confidence":1,"confidence_rate":1},{"cnt":[[125,1177],[2002,1177],[2002,2013],[125,2013]],"region":{"top_left_x":124,"top_left_y":1177,"width":1879,"height":837},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8970eb1db14b462598f24b8bae9619b3","type":"table","conversion_output":true,"children_ids":["0d16f1f8c59840d0a1ab88b0d6754b65","e369ebebe7664fc3b55256ff48513181","073889f924f74da48ab7e8d32e14d8cc","3798d6ac9f95441ca7c1f374644a2ce3","936676f7f8e345e5bb7149ba7554bcc3","f52056cd4a4b473eaffb3ec46e32d4e5","6ece268da7b34022b76ab7d26d7759c4","5f6c65e0c0384e0b894fe5e6bf2804ec","57491809511a4d4889ca39d136a03304","172a9ed459724f8ba70165d8a5158bd3","d0d9166a023441b1b70fed2060ea6d53","21a9e41499514ee6a2122866a99528a4","dd16f62b34914b50886580111aa93e5d","d15d62f82c7f4ee8963145cc4512802c","a6db7dafc64d4128b2bee4af3d4dd083","bc0a1a74db8f4f0b961f6120dc295b05","d449b1a0cc594a019a7d2819e4c45cb1","db96676421ae43bb833f8becbb20a839","baf5c0263a3d4fbc91f6719e2f8f732b"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Version (date) & Section & Brief Summary of Modification \\\\\n\\hline Version 9.0 (12/18/15) & 1, 6.1, 15.6.1, 15.6.2, Table 5 & The original target sample size was 150 per group. Because of recruitment difficulties, the DSMB approved a new target sample size of 105 per group. The target sample size was revised in several sections of the protocol and the power calculations with the new sample size were updated in section 15.6.1, section 15.6.2, and Table 5. As recommended by the DSMB, the revised power calculations were based on the rate of loss to follow-up and the rate of nonadherence observed among the first 88 study participants. \\\\\n\\hline Version 9.0 (12/18/15) & 15.5, Table 4 & Due to the change in target sample size, the DSMB approved a change to the critical values used for the four remaining interim analyses. Changes were made to section 15.5 and Table 4 to reflect the revised plan. \\\\\n\\hline Version 9.0 (12/18/15) & 15, 15.1, 15.6.1 & In version 8.0 of the protocol there was inconsistency with respect to the analysis plan for the primary outcome. In several sections it was stated that the primary outcome (community ambulation at 16 weeks) would be assessed using a two-sided 0.05 -level test. However, the interim analysis plan (which specified the interim analyses and the final analysis) was to perform a one-sided 0.025 -level test at each time point. Therefore, we modified the proposal so that it consistently says that for the primary analysis we will use a one-sided 0.025 -level test. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version (date) & Section & Brief Summary of Modification \\\\\n\\hline Version 9.0 (12/18/15) & 1, 6.1, 15.6.1, 15.6.2, Table 5 & The original target sample size was 150 per group. Because of recruitment difficulties, the DSMB approved a new target sample size of 105 per group. The target sample size was revised in several sections of the protocol and the power calculations with the new sample size were updated in section 15.6.1, section 15.6.2, and Table 5. As recommended by the DSMB, the revised power calculations were based on the rate of loss to follow-up and the rate of nonadherence observed among the first 88 study participants. \\\\\n\\hline Version 9.0 (12/18/15) & 15.5, Table 4 & Due to the change in target sample size, the DSMB approved a change to the critical values used for the four remaining interim analyses. Changes were made to section 15.5 and Table 4 to reflect the revised plan. \\\\\n\\hline Version 9.0 (12/18/15) & 15, 15.1, 15.6.1 & In version 8.0 of the protocol there was inconsistency with respect to the analysis plan for the primary outcome. In several sections it was stated that the primary outcome (community ambulation at 16 weeks) would be assessed using a two-sided 0.05 -level test. However, the interim analysis plan (which specified the interim analyses and the final analysis) was to perform a one-sided 0.025 -level test at each time point. 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In the proposed protocol, it will be possible for missed visits in a","confidence":1,"confidence_rate":1},{"cnt":[[899,2350],[1973,2350],[1973,2391],[899,2391]],"region":{"top_left_x":899,"top_left_y":2349,"width":1075,"height":42},"line":120,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a24dc337143041318c41afddb94323ef","type":"text","conversion_output":false,"parent_id":"a1d0e05509584e728c61ef87d1f391e2","text":"given week to be replaced by performing makeup visits in subsequent weeks","text_display":" given week to be replaced by performing makeup visits in subsequent weeks","confidence":1,"confidence_rate":1},{"cnt":[[899,2389],[1932,2389],[1932,2430],[899,2430]],"region":{"top_left_x":899,"top_left_y":2388,"width":1034,"height":42},"line":121,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fff447bbeaf48ac9aa0ae195fcd9835","type":"text","conversion_output":false,"parent_id":"a1d0e05509584e728c61ef87d1f391e2","text":"(not to exceed 3 visits in any given week) as long as the visits are on non-","text_display":" (not to exceed 3 visits in any given week) as long as the visits are on non","confidence":1,"confidence_rate":1},{"cnt":[[899,2427],[1969,2427],[1969,2471],[899,2471]],"region":{"top_left_x":899,"top_left_y":2427,"width":1070,"height":44},"line":122,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01c7323bb9fc410bb9d606f403d704e0","type":"text","conversion_output":false,"parent_id":"a1d0e05509584e728c61ef87d1f391e2","text":"consecutive days. Furthermore, if the participant has not had 32 visits by the","text_display":"consecutive days. Furthermore, if the participant has not had 32 visits by the","confidence":0.9990236759185791,"confidence_rate":0.9999886419133848},{"cnt":[[899,2469],[1956,2469],[1956,2512],[899,2512]],"region":{"top_left_x":899,"top_left_y":2468,"width":1058,"height":44},"line":123,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"931275d2b9354f9f942892faad8f6ec2","type":"text","conversion_output":false,"parent_id":"a1d0e05509584e728c61ef87d1f391e2","text":"end of 16 weeks, we are allowing makeup visits to be performed during the","text_display":" end of 16 weeks, we are allowing makeup visits to be performed during the","confidence":1,"confidence_rate":1},{"cnt":[[899,2508],[1928,2508],[1928,2549],[899,2549]],"region":{"top_left_x":899,"top_left_y":2507,"width":1029,"height":42},"line":124,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5f1cc73a7784e9eb5b8cd70265cf8c5","type":"text","conversion_output":false,"parent_id":"a1d0e05509584e728c61ef87d1f391e2","text":"subsequent two weeks to get as close as possible to the target of 32 visits.","text_display":" subsequent two weeks to get as close as possible to the target of 32 visits.","confidence":1,"confidence_rate":1},{"cnt":[[899,2547],[1887,2547],[1887,2590],[899,2590]],"region":{"top_left_x":899,"top_left_y":2546,"width":988,"height":44},"line":125,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e878ba8bb4f4f918d49750581474a80","type":"text","conversion_output":false,"parent_id":"a1d0e05509584e728c61ef87d1f391e2","text":"The purpose of this modification is to increase intervention adherence.","text_display":" The purpose of this modification is to increase intervention adherence.","confidence":0.99951171875,"confidence_rate":0.9999935736983052}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-003","page":3,"lines":[{"cnt":[[127,172],[1998,172],[1998,823],[127,823]],"region":{"top_left_x":126,"top_left_y":171,"width":1873,"height":652},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dfd34b5dbfb413f8c12efc515f81ae7","type":"table","conversion_output":true,"children_ids":["ea6867f318984f8a8a74c0dc54d79b69","7e8b0bf703514fb8915deb6a0922b571","8021f1b82ccf41f8b465fdc6a93193ac","7058d77bd89844fb82aeb05d843d2429","76d87ef557b84649981d39b154b96219","9f67e821acf949e191537da94bf2fe16","d7c2c1b1bcc34307bc307efc26082ab4","c78547484ace427aaf524e12429e35ae","a4698f6ec21c4da586c7ad409eb4aea6","3c0637fde91e4999a660c7f234230d69","d0de485bb55947758296f68abb21bdba"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Version 8.0 (10/2/15) & 1, 9.2, 10.4.9, 12.1.7, and Table 2 & In the previous protocol participants who were at risk of malnutrition and those who were malnourished, based on the Mini Nutritional AssessmentShort Form (MNA \\({ }^{( R )- SF ) \\text { score and serum albumin level, received an in- }}\\) person visit from a registered dietician (RD). However, it was found that many participants in the at-risk group did not require an in-person visit. Therefore, in the proposed protocol, participants in the at-risk group based MNA®-SF score and with a normal serum albumin level will receive a phone call from the RD and will only receive a follow-up in-person visit if the RD believes it is necessary. \\\\\n\\hline Version 8.0 (10/2/15) & 11.5, 15.1 & The protocol was revised to reflect changes in the way adjudication will be performed. In the proposed version, all three adjudicators will discuss the case if the two assigned adjudicators do not reach consensus. The three adjudicators will vote on the case if they are unable to reach consensus. Also, cases where the Six-Minute Walk Test was administered but not according to protocol (e.g., using a walking course of less than 10 m ) will now be submitted for adjudication. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version 8.0 (10/2/15) & 1, 9.2, 10.4.9, 12.1.7, and Table 2 & In the previous protocol participants who were at risk of malnutrition and those who were malnourished, based on the Mini Nutritional AssessmentShort Form (MNA \\({ }^{( R )- SF ) \\text { score and serum albumin level, received an in- }}\\) person visit from a registered dietician (RD). However, it was found that many participants in the at-risk group did not require an in-person visit. Therefore, in the proposed protocol, participants in the at-risk group based MNA®-SF score and with a normal serum albumin level will receive a phone call from the RD and will only receive a follow-up in-person visit if the RD believes it is necessary. \\\\\n\\hline Version 8.0 (10/2/15) & 11.5, 15.1 & The protocol was revised to reflect changes in the way adjudication will be performed. In the proposed version, all three adjudicators will discuss the case if the two assigned adjudicators do not reach consensus. The three adjudicators will vote on the case if they are unable to reach consensus. Also, cases where the Six-Minute Walk Test was administered but not according to protocol (e.g., using a walking course of less than 10 m ) will now be submitted for adjudication. 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(RD). However, it was found that many participants in the at-risk group did not require an in-person visit. Therefore, in the proposed protocol, participants in the at-risk group based MNA®-SF score and with a normal serum albumin level will receive a phone call from the RD and will only receive a follow-up in-person visit if the RD believes it is necessary.","text_display":"In the previous protocol participants who were at risk of malnutrition and those who were malnourished, based on the Mini Nutritional AssessmentShort Form (MNA \\({ }^{( R )- SF ) \\text { score and serum albumin level, received an in- }}\\) person visit from a registered dietician (RD). However, it was found that many participants in the at-risk group did not require an in-person visit. Therefore, in the proposed protocol, participants in the at-risk group based MNA®-SF score and with a normal serum albumin level will receive a phone call from the RD and will only receive a follow-up in-person visit if the RD believes it is necessary.","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.11799782607201427,"confidence_rate":0.997311908026239},{"cnt":[[901,180],[1926,180],[1926,219],[901,219]],"region":{"top_left_x":901,"top_left_y":179,"width":1025,"height":40},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e8d044f4fce435bb540d238b8088a1c","type":"text","conversion_output":false,"parent_id":"c78547484ace427aaf524e12429e35ae","text":"In the previous protocol participants who were at risk of malnutrition and","text_display":"In the previous protocol participants who were at risk of malnutrition and","confidence":1,"confidence_rate":1},{"cnt":[[901,219],[1934,219],[1934,255],[901,255]],"region":{"top_left_x":901,"top_left_y":218,"width":1034,"height":38},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"187ce61659b94cccae07afa1985f10d6","type":"text","conversion_output":false,"parent_id":"c78547484ace427aaf524e12429e35ae","text":"those who were malnourished, based on the Mini Nutritional Assessment-","text_display":" those who were malnourished, based on the Mini Nutritional Assessment","confidence":1,"confidence_rate":1},{"cnt":[[901,260],[1913,260],[1913,299],[901,299]],"region":{"top_left_x":901,"top_left_y":259,"width":1012,"height":40},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc225b5a2c5146e1add4aac7be4a7132","type":"text","conversion_output":false,"parent_id":"c78547484ace427aaf524e12429e35ae","text":"Short Form (MNA \\({ }^{( R )- SF ) \\text { score and serum albumin level, received an in- }}\\)","text_display":"Short Form (MNA \\({ }^{( R )- SF ) \\text { score and serum albumin level, received an in- }}\\)","confidence":0.11799782607201427,"confidence_rate":0.9767891193146084},{"cnt":[[901,301],[1917,301],[1917,338],[901,338]],"region":{"top_left_x":901,"top_left_y":300,"width":1016,"height":38},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44ae039c4b0840139215b7c941d10566","type":"text","conversion_output":false,"parent_id":"c78547484ace427aaf524e12429e35ae","text":"person visit from a registered dietician (RD). 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In this version of the protocol, the frequency in the first eight weeks has been reduced to two times per week so that participants will receive two visits per week for all 16 weeks. The intensity and total duration of the interventions will not change and there is no evidence in the literature indicating that a frequency of three days per week is superior to two days per week for improving strength or function. Reducing the frequency may increase participation, may increase participants' willingness to start the intervention earlier in the post-fracture period, and may improve adherence to the intervention schedule. Changes were made throughout the protocol to reflect the reduction in the total number of intervention visits from 40 to 32. \\\\\n\\hline Version 6.0 (11/21/14) & All sections & Changes were made throughout the protocol to reflect revisions made to the inclusion and exclusion criteria. \\\\\n\\hline Version 6.0 (11/21/14) & All sections & We have removed references to the appendices throughout the protocol and removed Section 22 (Supplements/Appendix). Appendices provided with the original protocol submission represented draft documents and are no longer current, as these items continue to be modified to meet the operational needs of the study. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Summary of Modifications to Protocol Version 5.0.1 for Version 6.0}\n\\begin{tabular}{|l|l|l|}\n\\hline Version (date) & Section & Brief Summary of Modification \\\\\n\\hline Version 6.0 (11/21/14) & All sections & In the previous protocol, participants received three intervention visits per week in the first eight weeks of the intervention and two intervention visits per week in the second eight weeks. In this version of the protocol, the frequency in the first eight weeks has been reduced to two times per week so that participants will receive two visits per week for all 16 weeks. The intensity and total duration of the interventions will not change and there is no evidence in the literature indicating that a frequency of three days per week is superior to two days per week for improving strength or function. Reducing the frequency may increase participation, may increase participants' willingness to start the intervention earlier in the post-fracture period, and may improve adherence to the intervention schedule. Changes were made throughout the protocol to reflect the reduction in the total number of intervention visits from 40 to 32. \\\\\n\\hline Version 6.0 (11/21/14) & All sections & Changes were made throughout the protocol to reflect revisions made to the inclusion and exclusion criteria. \\\\\n\\hline Version 6.0 (11/21/14) & All sections & We have removed references to the appendices throughout the protocol and removed Section 22 (Supplements/Appendix). Appendices provided with the original protocol submission represented draft documents and are no longer current, as these items continue to be modified to meet the operational needs of the study. 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In this version of the protocol, the frequency in the first eight weeks has been reduced to two times per week so that participants will receive two visits per week for all 16 weeks. The intensity and total duration of the interventions will not change and there is no evidence in the literature indicating that a frequency of three days per week is superior to two days per week for improving strength or function. Reducing the frequency may increase participation, may increase participants' willingness to start the intervention earlier in the post-fracture period, and may improve adherence to the intervention schedule. Changes were made throughout the protocol to reflect the reduction in the total number of intervention visits from 40 to 32.","text_display":"In the previous protocol, participants received three intervention visits per week in the first eight weeks of the intervention and two intervention visits per week in the second eight weeks. 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The","confidence":1,"confidence_rate":1},{"cnt":[[899,1941],[1952,1941],[1952,1983],[899,1983]],"region":{"top_left_x":899,"top_left_y":1941,"width":1053,"height":42},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b96d2920dc184995b6574579bb594ab7","type":"text","conversion_output":false,"parent_id":"6f8bf01f0c344019b7720bd9a3697dd7","text":"intensity and total duration of the interventions will not change and there is","text_display":" intensity and total duration of the interventions will not change and there is","confidence":1,"confidence_rate":1},{"cnt":[[899,1980],[1917,1980],[1917,2022],[899,2022]],"region":{"top_left_x":899,"top_left_y":1980,"width":1019,"height":42},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7893e37e06374bfca4a2c586e9cfb72b","type":"text","conversion_output":false,"parent_id":"6f8bf01f0c344019b7720bd9a3697dd7","text":"no evidence in the literature indicating that a frequency of three days per","text_display":" no evidence in the literature indicating that a frequency of three days per","confidence":0.9990234375,"confidence_rate":0.9999877870789805},{"cnt":[[899,2022],[1932,2022],[1932,2061],[899,2061]],"region":{"top_left_x":899,"top_left_y":2021,"width":1034,"height":40},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b042467458254c028505174ccbe53eba","type":"text","conversion_output":false,"parent_id":"6f8bf01f0c344019b7720bd9a3697dd7","text":"week is superior to two days per week for improving strength or function.","text_display":" week is superior to two days per week for improving strength or function.","confidence":1,"confidence_rate":1},{"cnt":[[899,2063],[1815,2063],[1815,2104],[899,2104]],"region":{"top_left_x":899,"top_left_y":2062,"width":917,"height":42},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4f860574612440ca577c92c51dd877a","type":"text","conversion_output":false,"parent_id":"6f8bf01f0c344019b7720bd9a3697dd7","text":"Reducing the frequency may increase participation, may increase","text_display":" Reducing the frequency may increase participation, may increase","confidence":1,"confidence_rate":1},{"cnt":[[899,2102],[1950,2102],[1950,2143],[899,2143]],"region":{"top_left_x":899,"top_left_y":2101,"width":1051,"height":42},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34d13d92459c464588964e7bf2d108c2","type":"text","conversion_output":false,"parent_id":"6f8bf01f0c344019b7720bd9a3697dd7","text":"participants' willingness to start the intervention earlier in the post-fracture","text_display":" participants' willingness to start the intervention earlier in the post-fracture","confidence":0.99560546875,"confidence_rate":0.9999481870413384},{"cnt":[[899,2141],[1937,2141],[1937,2182],[899,2182]],"region":{"top_left_x":899,"top_left_y":2140,"width":1038,"height":42},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2992d4e02378481a86af9d914817977c","type":"text","conversion_output":false,"parent_id":"6f8bf01f0c344019b7720bd9a3697dd7","text":"period, and may improve adherence to the intervention schedule. Changes","text_display":" period, and may improve adherence to the intervention schedule. Changes","confidence":1,"confidence_rate":1},{"cnt":[[899,2180],[1876,2180],[1876,2221],[899,2221]],"region":{"top_left_x":899,"top_left_y":2179,"width":977,"height":42},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e479c3026fe4335be55f9ae44564de2","type":"text","conversion_output":false,"parent_id":"6f8bf01f0c344019b7720bd9a3697dd7","text":"were made throughout the protocol to reflect the reduction in the total","text_display":" were made throughout the protocol to reflect the reduction in the total","confidence":1,"confidence_rate":1},{"cnt":[[899,2219],[1516,2219],[1516,2255],[899,2255]],"region":{"top_left_x":899,"top_left_y":2218,"width":618,"height":38},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"410ab50275ca404bb841f48b7fd11703","type":"text","conversion_output":false,"parent_id":"6f8bf01f0c344019b7720bd9a3697dd7","text":"number of intervention visits from 40 to 32.","text_display":" number of 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(11/21/14)","confidence":1,"confidence_rate":1},{"cnt":[[397,2262],[572,2262],[572,2299],[397,2299]],"region":{"top_left_x":396,"top_left_y":2261,"width":177,"height":38},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23357828aad04eb2ac886f5f053cb8b6","type":"simple_cell","conversion_output":false,"parent_id":"d7dbdce3bb2c455ba19a2bed9fd1a813","text":"All sections","text_display":"All sections","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[897,2262],[1965,2262],[1965,2340],[897,2340]],"region":{"top_left_x":897,"top_left_y":2261,"width":1068,"height":79},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fbdce4037744386be6c1f73bff431c8","type":"complex_cell","conversion_output":false,"parent_id":"d7dbdce3bb2c455ba19a2bed9fd1a813","children_ids":["4191caf3d4794e85b6f6cf84ae93b0ec","da778d8ae9b74e55a95a9d18837e414c"],"text":"Changes were made throughout the protocol to reflect revisions made to the inclusion and exclusion criteria.","text_display":"Changes were made throughout the protocol to reflect revisions made to the inclusion and exclusion criteria.","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,2262],[1963,2262],[1963,2303],[899,2303]],"region":{"top_left_x":899,"top_left_y":2261,"width":1064,"height":43},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4191caf3d4794e85b6f6cf84ae93b0ec","type":"text","conversion_output":false,"parent_id":"3fbdce4037744386be6c1f73bff431c8","text":"Changes were made throughout the protocol to reflect revisions made to the","text_display":"Changes were made throughout the protocol to reflect revisions made to the","confidence":1,"confidence_rate":1},{"cnt":[[899,2301],[1350,2301],[1350,2338],[899,2338]],"region":{"top_left_x":899,"top_left_y":2300,"width":451,"height":38},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da778d8ae9b74e55a95a9d18837e414c","type":"text","conversion_output":false,"parent_id":"3fbdce4037744386be6c1f73bff431c8","text":"inclusion and exclusion criteria.","text_display":" inclusion and exclusion criteria.","confidence":1,"confidence_rate":1},{"cnt":[[146,2340],[317,2340],[317,2424],[146,2424]],"region":{"top_left_x":145,"top_left_y":2339,"width":172,"height":86},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbfe8bd69a2d4a4aaeef6b457c6fbf7d","type":"complex_cell","conversion_output":false,"parent_id":"d7dbdce3bb2c455ba19a2bed9fd1a813","children_ids":["7823f771d2c34d3895a81601be20045a","1908bfea096e42648ef22b640b0e6ff5"],"text":"Version 6.0 (11/21/14)","text_display":"Version 6.0 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(11/21/14)","confidence":1,"confidence_rate":1},{"cnt":[[397,2344],[572,2344],[572,2381],[397,2381]],"region":{"top_left_x":396,"top_left_y":2344,"width":177,"height":38},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"265fcf82b7254feba25d76180646aa74","type":"simple_cell","conversion_output":false,"parent_id":"d7dbdce3bb2c455ba19a2bed9fd1a813","text":"All sections","text_display":"All 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Appendices provided with the original protocol submission represented draft documents and are no longer current, as these items continue to be modified to meet the operational needs of the study.","text_display":"We have removed references to the appendices throughout the protocol and removed Section 22 (Supplements/Appendix). Appendices provided with the original protocol submission represented draft documents and are no longer current, as these items continue to be modified to meet the operational needs of the study.","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,2344],[1956,2344],[1956,2385],[899,2385]],"region":{"top_left_x":899,"top_left_y":2344,"width":1058,"height":42},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ee85f6e23e2408bb10992d17ff0e28c","type":"text","conversion_output":false,"parent_id":"aa65a7dd01d64b7694393b3d0f479ec0","text":"We have removed references to the appendices throughout the protocol and","text_display":"We have removed references to the appendices throughout the protocol and","confidence":1,"confidence_rate":1},{"cnt":[[899,2383],[1980,2383],[1980,2424],[899,2424]],"region":{"top_left_x":899,"top_left_y":2383,"width":1081,"height":42},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bceb5f82d43a41a4ac238f49eecd84d6","type":"text","conversion_output":false,"parent_id":"aa65a7dd01d64b7694393b3d0f479ec0","text":"removed Section 22 (Supplements/Appendix). Appendices provided with the","text_display":" removed Section 22 (Supplements/Appendix). Appendices provided with the","confidence":1,"confidence_rate":1},{"cnt":[[899,2422],[1958,2422],[1958,2463],[899,2463]],"region":{"top_left_x":899,"top_left_y":2422,"width":1060,"height":42},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c592c87e94c4bb98aec96bcc382f879","type":"text","conversion_output":false,"parent_id":"aa65a7dd01d64b7694393b3d0f479ec0","text":"original protocol submission represented draft documents and are no longer","text_display":" original protocol submission represented draft documents and are no longer","confidence":1,"confidence_rate":1},{"cnt":[[899,2461],[1971,2461],[1971,2505],[899,2505]],"region":{"top_left_x":899,"top_left_y":2461,"width":1073,"height":44},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00394372a179432fa79e4c5c3e747b0f","type":"text","conversion_output":false,"parent_id":"aa65a7dd01d64b7694393b3d0f479ec0","text":"current, as these items continue to be modified to meet the operational needs","text_display":" current, as these items continue to be modified to meet the operational needs","confidence":1,"confidence_rate":1},{"cnt":[[899,2505],[1079,2505],[1079,2544],[899,2544]],"region":{"top_left_x":899,"top_left_y":2504,"width":180,"height":40},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64a63b3c80a64bbb97628cd2e2402ad6","type":"text","conversion_output":false,"parent_id":"aa65a7dd01d64b7694393b3d0f479ec0","text":"of the study.","text_display":" of the study.","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-004","page":4,"lines":[{"cnt":[[122,168],[2004,168],[2004,1966],[122,1966]],"region":{"top_left_x":122,"top_left_y":167,"width":1883,"height":1799},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"688f2f8e3ded4169a0f4eddd1a20f6ff","type":"table","conversion_output":true,"children_ids":["02ab54b603794105bbde7ca19e7d7d2f","aca5c1d26cf647febdb81c79969ab966","d3c530f8f1fa4029b9aac3473de96320","5dc2eef51fc34a0c9da9b6625cc299fe","6fb9489080234acc9d8dc9fb5d442ad0","ba7633e8525947de8bc81e3d363d20d7","70fe7b3bcd554a42b5cd63e211c43758","095727772ee04094ab2f358215a31486","8a2237ee15dc4ec5ab55953b918af529","06cd163248784f228a441e51869c4844","199812be4bb840879e8debd23279b9d8","ef8360c4a44f4d5f9c28da7d446e733d","1c136586e3e946a4b23c5bed3e442ca1","326bdb17c3654d9696ff9bb8a07bc072","500c540dbf30478787eec56253ae34cc","0b0931f447874a578f8faf491cc39bf1","a27229d32722423a95e57e8bbc07f268","4e1c411a37604f9284d42e90a781d170","2fa88ea58b734d858f9e28034cf16bdb","b52153517506431fa2a01c1b25a19702","78de2892cf084ad4b2e347cee2610553","60276f6aa5e540b5b80d84adb6cb7cd9","57737893b7354e2d85555e34cf39a0ca","b252b58554184f4aab2141cc1eccbfc2","55dbeb853c46407fb2a0eb4d93163309","8e30bbd8794b4f3eaae47f65a77a9d47","55a9850cdc3f42ea9fad9e8a5a17c732","2f65962501894fafa3645f44f0ed586f","538e5dcc144144dcbc46f5c0ca73ef8f","bf178aa092a94930a439b115d3d37a95","760b036caf0d4af0b305217dfebfa337","4bf8879cb43148b9a6d82d58bf482fd5","b3d342ec504347c09a9a46994cbbdf45","4525da79615440df9707a132f5333f1e","b88efe16c66e4409aaeb7bd1c73c6fed","4cbba8b065a9471398e5c4c00bedda56","b2ed5f8bde734ac7b27c873e4fb6cbb3","5b1a812d81ae4cd099cca6db2976796e","61450568aa7c40e0b14ae88f99ec3e0a","fa4ef8fe65d2412d882e33241366734c","4976399dd2e543e1ae765b8df93e3bab","19ff52eed7784185a95dce89eda369d4","2f535cad12c140ec8eba969cd77c94ae","3e705b3b436b4328bbc052f421ab5a6f","edaca0ecfcfa4591be347327ac8f0088","f646e1ba6ee44df191f50c332efb7918","0008e19a952549c9a54e18cc247740b6","e8af49b69baa4e46894effdc4823cc33","0c50236a51e94ce3bc655cd5d01452ea","acf6e1d8747048399f9b6cadcd059a18","41e82dc2723543599daf3fc0144465d7","321ef9e97ae54f8faf778c82a98ded1f","34d918e53fc94e00a7bc0072a55aa6dd","6c9d190922c240b2af65f1acfeaff2fb","b297a75c75de44feb61394cb4bc316be","70d4198c613f408c9af345c82ef85c42","4228a3df1eac4612aa093399c971d33d","10a1fe48a726479995256f5f8d241684","d37a835b676a430a95633b1d32deaf0a"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Version 6.0 (11/21/14) & 7.2 (criterion 1.1) & We have removed the ICD codes from this criterion. The operational definition of hip fracture diagnosis is not based on ICD codes since they are not available at the time of screening. \\\\\n\\hline Version 6.0 (11/21/14) & 7.2 (criteria 1.3 and 1.6) & Unilateral hip fracture and stress fracture were deleted as eligibility criteria since patients with these types of fractures can safely perform and can benefit from the study interventions. \\\\\n\\hline Version 6.0 (11/21/14) & 7.2 (criterion 1.7) & Orthopedic surgeon permission to contact patient was deleted as a studywide exclusion criterion since this is not required at all sites. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 4.5) & The interval between hospital admission and randomization was extended to 26 weeks. This may help increase participation of people who need more time to complete usual home therapy before starting the study interventions. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criteria 5.3-5.10, 5.12, 5.13, 5.16, and 6.11-6.13) & These 14 medical criteria were deleted as exclusions to avoid unnecessarily screening out patients who could safely perform the study interventions and benefit from them. Clinical site clinicians will review all potentially eligible patients to ensure that they can safely participate in the study. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 5.18) & Severe lower extremity pain with ambulation was deleted as an exclusion criterion. Significant pain while walking will now be assessed during the baseline administration of the Six-Minute Walk Test (SMWT) (criterion 6.10). \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 6.10) & This criterion has been revised to exclude patients who develop severe pain during the baseline SMWT. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 5.21) & The exclusion criterion was revised to be specific to receiving physical therapy in a hospital or inpatient rehabilitation facility at the time of randomization. Patients receiving physical therapy at home will be eligible to begin the study interventions. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 6.7) & This criterion was revised to exclude people who are not fully weightbearing on either the fractured or non-fractured leg at time of randomization. \\\\\n\\hline Version 6.0 (11/21/14) & Tables 1 and 2 & Tables 1 and 2 were removed in order to simplify the study protocol, as this information is already presented in the text. \\\\\n\\hline Version 6.0 (11/21/14) & 8.2, 11.5, and Table 3 & We have added an out-of-window time interval in order to collect data for the 16-week follow-up visit earlier than the allowable window. The additional out-of-window interval is \\(0-16\\) weeks post-randomization, which covers the period from the date of randomization to the earliest date for the 16-week visit. Although assessment visits are always done as close as possible to the target date, this change will increase the probability of obtaining complete follow-up data, even for participants whose assessments are difficult to schedule. \\\\\n\\hline Version 6.0 (11/21/14) & 15.1 & A few paragraphs were added describing the analysis to address the change in intervention frequency during the first eight weeks of the intervention from three times per week to twice per week. \\\\\n\\hline Version 6.0 (11/21/14) & 15.1 & We modified the category for age at baseline from \"65 to 84 years\" to \"6084 years\" to reflect the current age eligibility criterion. \\\\\n\\hline Version 6.0 (11/21/14) & 20 & Updates were made to the Study Team Roster. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version 6.0 (11/21/14) & 7.2 (criterion 1.1) & We have removed the ICD codes from this criterion. The operational definition of hip fracture diagnosis is not based on ICD codes since they are not available at the time of screening. \\\\\n\\hline Version 6.0 (11/21/14) & 7.2 (criteria 1.3 and 1.6) & Unilateral hip fracture and stress fracture were deleted as eligibility criteria since patients with these types of fractures can safely perform and can benefit from the study interventions. \\\\\n\\hline Version 6.0 (11/21/14) & 7.2 (criterion 1.7) & Orthopedic surgeon permission to contact patient was deleted as a studywide exclusion criterion since this is not required at all sites. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 4.5) & The interval between hospital admission and randomization was extended to 26 weeks. This may help increase participation of people who need more time to complete usual home therapy before starting the study interventions. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criteria 5.3-5.10, 5.12, 5.13, 5.16, and 6.11-6.13) & These 14 medical criteria were deleted as exclusions to avoid unnecessarily screening out patients who could safely perform the study interventions and benefit from them. Clinical site clinicians will review all potentially eligible patients to ensure that they can safely participate in the study. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 5.18) & Severe lower extremity pain with ambulation was deleted as an exclusion criterion. Significant pain while walking will now be assessed during the baseline administration of the Six-Minute Walk Test (SMWT) (criterion 6.10). \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 6.10) & This criterion has been revised to exclude patients who develop severe pain during the baseline SMWT. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 5.21) & The exclusion criterion was revised to be specific to receiving physical therapy in a hospital or inpatient rehabilitation facility at the time of randomization. Patients receiving physical therapy at home will be eligible to begin the study interventions. \\\\\n\\hline Version 6.0 (11/21/14) & 7.3 (criterion 6.7) & This criterion was revised to exclude people who are not fully weightbearing on either the fractured or non-fractured leg at time of randomization. \\\\\n\\hline Version 6.0 (11/21/14) & Tables 1 and 2 & Tables 1 and 2 were removed in order to simplify the study protocol, as this information is already presented in the text. \\\\\n\\hline Version 6.0 (11/21/14) & 8.2, 11.5, and Table 3 & We have added an out-of-window time interval in order to collect data for the 16-week follow-up visit earlier than the allowable window. The additional out-of-window interval is \\(0-16\\) weeks post-randomization, which covers the period from the date of randomization to the earliest date for the 16-week visit. Although assessment visits are always done as close as possible to the target date, this change will increase the probability of obtaining complete follow-up data, even for participants whose assessments are difficult to schedule. \\\\\n\\hline Version 6.0 (11/21/14) & 15.1 & A few paragraphs were added describing the analysis to address the change in intervention frequency during the first eight weeks of the intervention from three times per week to twice per week. \\\\\n\\hline Version 6.0 (11/21/14) & 15.1 & We modified the category for age at baseline from \"65 to 84 years\" to \"6084 years\" to reflect the current age eligibility criterion. \\\\\n\\hline Version 6.0 (11/21/14) & 20 & Updates were made to the Study Team Roster. 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The correct wording of criterion 6.11 is \"Total hip replacement or prior hip fracture on same side as study index hip fracture.\" The operationalization of criterion 6.11 has not changed.","text_display":"Modified the criterion to remove the word \"recent\", which was added in error in version 5.0. The correct wording of criterion 6.11 is \"Total hip replacement or prior hip fracture on same side as study index hip fracture.\" The operationalization of criterion 6.11 has not changed.","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,2179],[1911,2179],[1911,2220],[899,2220]],"region":{"top_left_x":899,"top_left_y":2179,"width":1012,"height":42},"line":151,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9fc93a2ea4847268d3e966bba364433","type":"text","conversion_output":false,"parent_id":"6ca2efaacf484b479f1453dbe9951a48","text":"Modified the criterion to remove the word \"recent\", which was added in","text_display":"Modified the criterion to remove the word \"recent\", which was added in","confidence":1,"confidence_rate":1},{"cnt":[[899,2218],[1889,2218],[1889,2259],[899,2259]],"region":{"top_left_x":899,"top_left_y":2218,"width":990,"height":42},"line":152,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f0a4011901c4119be0efae905d3912c","type":"text","conversion_output":false,"parent_id":"6ca2efaacf484b479f1453dbe9951a48","text":"error in version 5.0. The correct wording of criterion 6.11 is \"Total hip","text_display":" error in version 5.0. The correct wording of criterion 6.11 is \"Total hip","confidence":1,"confidence_rate":1},{"cnt":[[899,2257],[1945,2257],[1945,2301],[899,2301]],"region":{"top_left_x":899,"top_left_y":2257,"width":1047,"height":44},"line":153,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f67e2336d4ff4df9b7f55dbaab1c4d07","type":"text","conversion_output":false,"parent_id":"6ca2efaacf484b479f1453dbe9951a48","text":"replacement or prior hip fracture on same side as study index hip fracture.\"","text_display":" replacement or prior hip fracture on same side as study index hip fracture.\"","confidence":1,"confidence_rate":1},{"cnt":[[899,2298],[1694,2298],[1694,2340],[899,2340]],"region":{"top_left_x":899,"top_left_y":2298,"width":795,"height":42},"line":154,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f1048ce20934630b3f07aa76916b41a","type":"text","conversion_output":false,"parent_id":"6ca2efaacf484b479f1453dbe9951a48","text":"The operationalization of criterion 6.11 has not changed.","text_display":" The operationalization of criterion 6.11 has not changed.","confidence":1,"confidence_rate":1},{"cnt":[[501,2376],[1626,2376],[1626,2438],[501,2438]],"region":{"top_left_x":500,"top_left_y":2376,"width":1127,"height":63},"line":155,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01f4bb63d4094115b3d6a05233c37c82","type":"section_header","conversion_output":false,"children_ids":["a20f2058e4e44abdb1308d1ea5bdc6e7"],"text":"","text_display":""},{"cnt":[[507,2385],[1618,2385],[1618,2434],[507,2434]],"region":{"top_left_x":507,"top_left_y":2384,"width":1111,"height":51},"line":156,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a20f2058e4e44abdb1308d1ea5bdc6e7","type":"text","conversion_output":true,"parent_id":"01f4bb63d4094115b3d6a05233c37c82","text":"Summary of Modifications to Protocol Version 4.0.1 for Version 5.0","text_display":"\n\n\\section*{Summary of Modifications to Protocol 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\\\\\n\\hline\n\\end{tabular}","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-005","page":5,"lines":[{"cnt":[[122,168],[2004,168],[2004,1420],[122,1420]],"region":{"top_left_x":122,"top_left_y":167,"width":1883,"height":1254},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"907449a499ba4ae094f5b94aa87e57c3","type":"table","conversion_output":true,"children_ids":["afdc018c04334ef890a1026e93ed9575","f8efbe090ce2436183650b09afae490f","b0119a456a274785a9f0756b46711116","1452a2078f2c45429756ed1a3753eb66","b59a572546e7487fb3664323655f8ed5","de1798c9c0a1447abd60141c90e2fa98","38b52c561a6e4d5d9f151b422ca1bade","b9d2df713b774b98a92584966084e1f4","6f49f4e3dde24627831355b494ca397e","253963bc1dc547278ca9cf16978d85d9","9f282444e533470f9a31521699ed05a9","f21f27fb92d24756b1cae6e1ebd53e94","3826d832654845c68bc61b755280c490","2c24d0a7389040b4851a3fb7f1e9b584","0540cfea1e9f4c8b8956ae695dd261b6","1255cb4ea44c43e2ae9d778f01462428","42fe32a5bd814bdb9ff88ffd2922a119","41382a461b384ee4bf80dbc2037a0db2","fcf8ae78345145e692fe39d9d1f4e8ef","4af33bd241b74eefbaf6c261b3b636d0","9a164fa8ef2848e69079587a6b75a4e3","f7b3a78df62d420d9ca52c0806b7485e","517b5e9a7bde490f9867b8b982761de1","acdfb13a299e4f8cbce9dad5fed62c41","5acc28d7a8244cb2b7347ea3dce90baf","d56a1533b29241bb9b06d0582cfc18c1","fbf4f8ede0fb4200a1680dc5f839374a","20f70fa065a34befbdeccd69bf8bc78d","8b45584cfc594817876f4107a0108cfb","79d599f508814d7c83ff93c5db46175f","9c6b4e3b86a34b5f9684ded97b1ab69c","701f59ef546342a98c627eeaf434ba73","ee9fb06bea6b474f8b99c22265ac9b90","f0b4922b9d484d3fb46ccc7fd88bc554","cc03121909794ed0b3f68a64a2fad7f9","7e29489309664980a9c529b2a2f7a005","4d362aa3c81f44c6a23e63fe7e66b6f0","61a94a053b5c4c15ae07b06487b36b00","d3cb020d7f964c9cb3380bfce09ca463","c56e2b8455e34458801e1f168132fc3b","3c3df05f29d644858a4c8774def9ff1d","f5e7a80cbbb2418195cf2e39a2cdc4c2","6456a29aa7a5425aa1a1f3405e5aa6e5","4eee1f9b66fc4c27bff24ee6f1785d77","745e2d503d014d2fad5783c0dad4b64e","605b995e058d4d5789074846ba3ab813","236ff10376a84a189460af2d865d544c","4ba57e2547094a2fa8670b8cb67506d0","d327d39d08074dfd8ff34fc222b39185","8646c9dfd425458bac62995b2d8970ee","c62b26be8e8041e79038a3b8674270dc"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Version 5.0 (4/17/14) & All sections & Changes were made throughout the protocol to capture revisions made to the inclusion and exclusion criteria. \\\\\n\\hline Version 5.0 (4/17/14) & 7.2 (criterion 1.4) & Eliminated the restriction for surgical fixation within seven days of admission. \\\\\n\\hline Version 5.0 (4/17/14) & 7.2 (criterion 2.1) & Lowered the age limit to 60 and older at time of randomization. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 4.5) & Widened the randomization window to 0 to 20 weeks post admission ( \\(10 \\pm\\) 10 weeks). This will help maximize participation of people who receive a shorter duration of regular PT post hip fracture and of those who receive a longer duration of PT. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 5.4) & Modified the BMI cutpoint to 17 and deleted the weight restriction due to some older hip fracture patients being of short stature. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 5.6) & This criterion has been broken out into 3 separate items in order to allow for specific operationalization related to Parkinson's Disease and for multiple sclerosis. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 5.13) & Deleted this criterion since individuals with contractures will be captured with other criteria. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 5.20) & Revised the criterion to be specific to receiving PT related to the hip fracture and removed OT since this should not interfere with the study. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criteria 6.11-6.13) & These three items were edited to capture recent surgeries and fractures of lower extremities to cover both the period prior to the hip fracture but also the period during screening for the study. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criteria 7.1-7.3) & Deleted these three items since they do not cause a safety risk for participating in the PT interventions. These items will be handled like history of kidney stones and participants will not receive calcium supplementation. \\\\\n\\hline Version 5.0 (4/17/14) & Table 1 & Table 1 was updated to reflect the edits to the criteria described above. \\\\\n\\hline Version 5.0 (4/17/14) & Table 3 & Phases 1-3 have been removed from Table 3 since we have widened the window for randomization to include 0-20 weeks. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version 5.0 (4/17/14) & All sections & Changes were made throughout the protocol to capture revisions made to the inclusion and exclusion criteria. \\\\\n\\hline Version 5.0 (4/17/14) & 7.2 (criterion 1.4) & Eliminated the restriction for surgical fixation within seven days of admission. \\\\\n\\hline Version 5.0 (4/17/14) & 7.2 (criterion 2.1) & Lowered the age limit to 60 and older at time of randomization. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 4.5) & Widened the randomization window to 0 to 20 weeks post admission ( \\(10 \\pm\\) 10 weeks). This will help maximize participation of people who receive a shorter duration of regular PT post hip fracture and of those who receive a longer duration of PT. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 5.4) & Modified the BMI cutpoint to 17 and deleted the weight restriction due to some older hip fracture patients being of short stature. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 5.6) & This criterion has been broken out into 3 separate items in order to allow for specific operationalization related to Parkinson's Disease and for multiple sclerosis. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 5.13) & Deleted this criterion since individuals with contractures will be captured with other criteria. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criterion 5.20) & Revised the criterion to be specific to receiving PT related to the hip fracture and removed OT since this should not interfere with the study. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criteria 6.11-6.13) & These three items were edited to capture recent surgeries and fractures of lower extremities to cover both the period prior to the hip fracture but also the period during screening for the study. \\\\\n\\hline Version 5.0 (4/17/14) & 7.3 (criteria 7.1-7.3) & Deleted these three items since they do not cause a safety risk for participating in the PT interventions. These items will be handled like history of kidney stones and participants will not receive calcium supplementation. \\\\\n\\hline Version 5.0 (4/17/14) & Table 1 & Table 1 was updated to reflect the edits to the criteria described above. \\\\\n\\hline Version 5.0 (4/17/14) & Table 3 & Phases 1-3 have been removed from Table 3 since we have widened the window for randomization to include 0-20 weeks. 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We are now submitting Version 4.0.1 which includes some minor editorial modifications to the version that has already been approved. Edits are limited to the summary table below and Table 3. We apologize for the error.","text_display":"When we recently submitted protocol Version 4.0 for approval by the DSMB, we inadvertently submitted a version that was not final. We are now submitting Version 4.0.1 which includes some minor editorial modifications to the version that has already been approved. Edits are limited to the summary table below and Table 3. We apologize for the error.","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,1633],[1872,1633],[1872,1674],[899,1674]],"region":{"top_left_x":899,"top_left_y":1633,"width":973,"height":42},"line":122,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91cdba919e004a5aba213b259ec94b71","type":"text","conversion_output":false,"parent_id":"3a838f2f92bd4be0b97d00116cb39295","text":"When we recently submitted protocol Version 4.0 for approval by the","text_display":"When we recently submitted protocol Version 4.0 for approval by the","confidence":1,"confidence_rate":1},{"cnt":[[899,1672],[1969,1672],[1969,1718],[899,1718]],"region":{"top_left_x":899,"top_left_y":1672,"width":1070,"height":46},"line":123,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"673ba55e1e5f4378a61c16dad9601339","type":"text","conversion_output":false,"parent_id":"3a838f2f92bd4be0b97d00116cb39295","text":"DSMB, we inadvertently submitted a version that was not final. 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Edits are limited to the","text_display":" to the version that has already been approved. Edits are limited to the","confidence":1,"confidence_rate":1},{"cnt":[[899,1794],[1772,1794],[1772,1835],[899,1835]],"region":{"top_left_x":899,"top_left_y":1793,"width":873,"height":42},"line":126,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7de82f5eaccc41f7838eaf41cecc5f56","type":"text","conversion_output":false,"parent_id":"3a838f2f92bd4be0b97d00116cb39295","text":"summary table below and Table 3. We apologize for the error.","text_display":" summary table below and Table 3. We apologize for the error.","confidence":1,"confidence_rate":1},{"cnt":[[146,1832],[343,1832],[343,1917],[146,1917]],"region":{"top_left_x":145,"top_left_y":1832,"width":198,"height":85},"line":127,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f105ed23ab884548a785472e4deb270a","type":"complex_cell","conversion_output":false,"parent_id":"b6c7e6a2f4384431ade0845ba1c4a985","children_ids":["af953ee843944c63b0e6237b7894d185","83b8bb17b9a54031b1f4b9668753d041"],"text":"Version 4.0.1 (3/18/14)","text_display":"Version 4.0.1 (3/18/14)","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[150,1837],[338,1837],[338,1874],[150,1874]],"region":{"top_left_x":149,"top_left_y":1836,"width":190,"height":38},"line":128,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af953ee843944c63b0e6237b7894d185","type":"text","conversion_output":false,"parent_id":"f105ed23ab884548a785472e4deb270a","text":"Version 4.0.1","text_display":"Version 4.0.1","confidence":1,"confidence_rate":1},{"cnt":[[148,1876],[282,1876],[282,1917],[148,1917]],"region":{"top_left_x":147,"top_left_y":1875,"width":136,"height":42},"line":129,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83b8bb17b9a54031b1f4b9668753d041","type":"text","conversion_output":false,"parent_id":"f105ed23ab884548a785472e4deb270a","text":"(3/18/14)","text_display":" (3/18/14)","confidence":1,"confidence_rate":1},{"cnt":[[397,1832],[572,1832],[572,1874],[397,1874]],"region":{"top_left_x":396,"top_left_y":1832,"width":177,"height":42},"line":130,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"760ac82901d8439c8ae7e0fec8f1bae5","type":"simple_cell","conversion_output":false,"parent_id":"b6c7e6a2f4384431ade0845ba1c4a985","text":"All sections","text_display":"All sections","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[895,1832],[1975,1832],[1975,2196],[895,2196]],"region":{"top_left_x":894,"top_left_y":1832,"width":1082,"height":365},"line":131,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09fb3508316b40e6a787e8bc8ba5f60b","type":"complex_cell","conversion_output":false,"parent_id":"b6c7e6a2f4384431ade0845ba1c4a985","children_ids":["3c1b5f3b82944a0fa557ae4cce0dd02b","34a703a3edd0417ea9fbbdb3d2f782dd","b2af1ec1a7a4443e9dedb453037739a4","8db685aca5f54cfabafacbbdec25571c","9013a8e021054846b44d926392f8dca7","544c3e4b429b4ca3b697cf509009e34e","dfee9165af1446dfaacb59ead1c188fa","1c40a0b3a8f54ca69509fba626c9dd0f","aff557cafe1c4798ac60503821bc5367"],"text":"In consultation with our Clinical Direction Committee, we are allowing nonphysician medical professionals to perform study activities related to evaluating medical eligibility and safety and to reviewing RAEs, provided those professionals are permitted by law to function autonomously (not under physician supervision) in the jurisdiction and the institution in which the clinical site is located. This change will facilitate clinical sites' access to appropriate clinicians who are available for time-sensitive study activities. \"Clinical Site Physician\" has been replaced with \"Clinical Site Clinician\" throughout the protocol.","text_display":"In consultation with our Clinical Direction Committee, we are allowing nonphysician medical professionals to perform study activities related to evaluating medical eligibility and safety and to reviewing RAEs, provided those professionals are permitted by law to function autonomously (not under physician supervision) in the jurisdiction and the institution in which the clinical site is located. This change will facilitate clinical sites' access to appropriate clinicians who are available for time-sensitive study activities. \"Clinical Site Physician\" has been replaced with \"Clinical Site Clinician\" throughout the protocol.","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.999998766364842},{"cnt":[[899,1837],[1973,1837],[1973,1878],[899,1878]],"region":{"top_left_x":899,"top_left_y":1836,"width":1075,"height":42},"line":132,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c1b5f3b82944a0fa557ae4cce0dd02b","type":"text","conversion_output":false,"parent_id":"09fb3508316b40e6a787e8bc8ba5f60b","text":"In consultation with our Clinical Direction Committee, we are allowing non-","text_display":"In consultation with our Clinical Direction Committee, we are allowing non","confidence":1,"confidence_rate":1},{"cnt":[[899,1876],[1863,1876],[1863,1917],[899,1917]],"region":{"top_left_x":899,"top_left_y":1875,"width":964,"height":42},"line":133,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34a703a3edd0417ea9fbbdb3d2f782dd","type":"text","conversion_output":false,"parent_id":"09fb3508316b40e6a787e8bc8ba5f60b","text":"physician medical professionals to perform study activities related to","text_display":"physician medical professionals to perform study activities related to","confidence":1,"confidence_rate":1},{"cnt":[[899,1915],[1939,1915],[1939,1960],[899,1960]],"region":{"top_left_x":899,"top_left_y":1914,"width":1040,"height":47},"line":134,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2af1ec1a7a4443e9dedb453037739a4","type":"text","conversion_output":false,"parent_id":"09fb3508316b40e6a787e8bc8ba5f60b","text":"evaluating medical eligibility and safety and to reviewing RAEs, provided","text_display":" evaluating medical eligibility and safety and to reviewing RAEs, provided","confidence":1,"confidence_rate":1},{"cnt":[[899,1954],[1898,1954],[1898,1999],[899,1999]],"region":{"top_left_x":899,"top_left_y":1953,"width":999,"height":47},"line":135,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8db685aca5f54cfabafacbbdec25571c","type":"text","conversion_output":false,"parent_id":"09fb3508316b40e6a787e8bc8ba5f60b","text":"those professionals are permitted by law to function autonomously (not","text_display":" those professionals are permitted by law to function autonomously (not","confidence":1,"confidence_rate":1},{"cnt":[[899,1995],[1952,1995],[1952,2038],[899,2038]],"region":{"top_left_x":899,"top_left_y":1994,"width":1053,"height":45},"line":136,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9013a8e021054846b44d926392f8dca7","type":"text","conversion_output":false,"parent_id":"09fb3508316b40e6a787e8bc8ba5f60b","text":"under physician supervision) in the jurisdiction and the institution in which","text_display":" under physician supervision) in the jurisdiction and the institution in which","confidence":1,"confidence_rate":1},{"cnt":[[899,2036],[1963,2036],[1963,2077],[899,2077]],"region":{"top_left_x":899,"top_left_y":2036,"width":1064,"height":42},"line":137,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"544c3e4b429b4ca3b697cf509009e34e","type":"text","conversion_output":false,"parent_id":"09fb3508316b40e6a787e8bc8ba5f60b","text":"the clinical site is located. This change will facilitate clinical sites' access to","text_display":" the clinical site is located. This change will facilitate clinical sites' access to","confidence":0.9990234375,"confidence_rate":0.9999888973383643},{"cnt":[[899,2075],[1941,2075],[1941,2116],[899,2116]],"region":{"top_left_x":899,"top_left_y":2075,"width":1042,"height":42},"line":138,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dfee9165af1446dfaacb59ead1c188fa","type":"text","conversion_output":false,"parent_id":"09fb3508316b40e6a787e8bc8ba5f60b","text":"appropriate clinicians who are available for time-sensitive study activities.","text_display":" appropriate clinicians who are available for time-sensitive study activities.","confidence":1,"confidence_rate":1},{"cnt":[[899,2114],[1930,2114],[1930,2157],[899,2157]],"region":{"top_left_x":899,"top_left_y":2114,"width":1032,"height":44},"line":139,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c40a0b3a8f54ca69509fba626c9dd0f","type":"text","conversion_output":false,"parent_id":"09fb3508316b40e6a787e8bc8ba5f60b","text":"\"Clinical Site Physician\" has been replaced with \"Clinical Site Clinician\"","text_display":" \"Clinical Site Physician\" has been replaced with \"Clinical Site Clinician\"","confidence":1,"confidence_rate":1},{"cnt":[[899,2155],[1244,2155],[1244,2196],[899,2196]],"region":{"top_left_x":899,"top_left_y":2155,"width":345,"height":42},"line":140,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aff557cafe1c4798ac60503821bc5367","type":"text","conversion_output":false,"parent_id":"09fb3508316b40e6a787e8bc8ba5f60b","text":"throughout the protocol.","text_display":" throughout the protocol.","confidence":1,"confidence_rate":1},{"cnt":[[146,2196],[343,2196],[343,2281],[146,2281]],"region":{"top_left_x":145,"top_left_y":2196,"width":198,"height":85},"line":141,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc5644116d944349b3651644c2852690","type":"complex_cell","conversion_output":false,"parent_id":"b6c7e6a2f4384431ade0845ba1c4a985","children_ids":["fb20e33a7e5f4b8c89ca4e60a8839a6e","7fd629c6e41c46d0972468738b4ca333"],"text":"Version 4.0.1 (3/18/14)","text_display":"Version 4.0.1 (3/18/14)","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[150,2196],[338,2196],[338,2233],[150,2233]],"region":{"top_left_x":149,"top_left_y":2196,"width":190,"height":38},"line":142,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb20e33a7e5f4b8c89ca4e60a8839a6e","type":"text","conversion_output":false,"parent_id":"cc5644116d944349b3651644c2852690","text":"Version 4.0.1","text_display":"Version 4.0.1","confidence":1,"confidence_rate":1},{"cnt":[[148,2237],[282,2237],[282,2279],[148,2279]],"region":{"top_left_x":147,"top_left_y":2237,"width":136,"height":42},"line":143,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fd629c6e41c46d0972468738b4ca333","type":"text","conversion_output":false,"parent_id":"cc5644116d944349b3651644c2852690","text":"(3/18/14)","text_display":" (3/18/14)","confidence":1,"confidence_rate":1},{"cnt":[[397,2196],[512,2196],[512,2237],[397,2237]],"region":{"top_left_x":396,"top_left_y":2196,"width":116,"height":42},"line":144,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5eaea8692d0741cea6ec440d6d1a8e5d","type":"simple_cell","conversion_output":false,"parent_id":"b6c7e6a2f4384431ade0845ba1c4a985","text":"Table 3","text_display":"Table 3","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[895,2196],[1965,2196],[1965,2359],[895,2359]],"region":{"top_left_x":894,"top_left_y":2196,"width":1071,"height":163},"line":145,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69b5b7d45dcf489aad843a4405cdde48","type":"complex_cell","conversion_output":false,"parent_id":"b6c7e6a2f4384431ade0845ba1c4a985","children_ids":["511d66e06f624e3aad5aa10d120d0f56","9752269c1541465f98b6c84bb2ec6524","eeb1370154ac400c840bf69a3b155e57","51f1274d375b41f1955e4d81f1d9319c"],"text":"The allowable interval for telephone interviews has been widened. The telephone interview can occur up to one week before and up to three weeks after the target date. Table 3 has been modified to correctly reflect this time window.","text_display":"The allowable interval for telephone interviews has been widened. The telephone interview can occur up to one week before and up to three weeks after the target date. Table 3 has been modified to correctly reflect this time window.","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999984346150134},{"cnt":[[899,2196],[1902,2196],[1902,2240],[899,2240]],"region":{"top_left_x":899,"top_left_y":2196,"width":1003,"height":44},"line":146,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"511d66e06f624e3aad5aa10d120d0f56","type":"text","conversion_output":false,"parent_id":"69b5b7d45dcf489aad843a4405cdde48","text":"The allowable interval for telephone interviews has been widened. The","text_display":"The allowable interval for telephone interviews has been widened. The","confidence":1,"confidence_rate":1},{"cnt":[[899,2237],[1954,2237],[1954,2281],[899,2281]],"region":{"top_left_x":899,"top_left_y":2237,"width":1055,"height":44},"line":147,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9752269c1541465f98b6c84bb2ec6524","type":"text","conversion_output":false,"parent_id":"69b5b7d45dcf489aad843a4405cdde48","text":"telephone interview can occur up to one week before and up to three weeks","text_display":" telephone interview can occur up to one week before and up to three weeks","confidence":0.99951171875,"confidence_rate":0.9999937384747559},{"cnt":[[899,2279],[1958,2279],[1958,2320],[899,2320]],"region":{"top_left_x":899,"top_left_y":2278,"width":1060,"height":42},"line":148,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eeb1370154ac400c840bf69a3b155e57","type":"text","conversion_output":false,"parent_id":"69b5b7d45dcf489aad843a4405cdde48","text":"after the target date. Table 3 has been modified to correctly reflect this time","text_display":" after the target date. 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The first out-of-window interval is 18-38 weeks post-randomization, which covers the period from the latest date for the 16-week visit to the earliest date for the 40-week visit. The second out-of-window interval is 44-68 weeks post-randomization, which covers the period from the latest date for the 40 -week visit to 24 weeks later. Although assessment visits are always done as close as possible to the target date, this change will increase the probability of obtaining complete follow-up data, even for participants whose assessments are difficult to schedule. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version 4.0.1 (3/18/14) & 8.2, 11.5, and Table 3 & We have added 2 out-of-window time intervals in order to collect data for the 16 - and 40-week follow-up visits outside the allowable window. The first out-of-window interval is 18-38 weeks post-randomization, which covers the period from the latest date for the 16-week visit to the earliest date for the 40-week visit. The second out-of-window interval is 44-68 weeks post-randomization, which covers the period from the latest date for the 40 -week visit to 24 weeks later. Although assessment visits are always done as close as possible to the target date, this change will increase the probability of obtaining complete follow-up data, even for participants whose assessments are difficult to schedule. \\\\\n\\hline\n\\end{tabular}","confidence":0.5938261151313782,"confidence_rate":0.999774725727116},{"cnt":[[143,171],[343,171],[343,578],[143,578]],"region":{"top_left_x":143,"top_left_y":171,"width":200,"height":408},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2a8554cedfe4068a141d1baa99de515","type":"table_column","conversion_output":false,"parent_id":"48061cbefa8b422099610ce810a15bf3","text":"","text_display":""},{"cnt":[[395,171],[711,171],[711,580],[395,580]],"region":{"top_left_x":394,"top_left_y":171,"width":317,"height":410},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ae53f3f60db4eb8bd5f8f3ef6996c52","type":"table_column","conversion_output":false,"parent_id":"48061cbefa8b422099610ce810a15bf3","text":"","text_display":""},{"cnt":[[895,171],[1952,171],[1952,585],[895,585]],"region":{"top_left_x":894,"top_left_y":171,"width":1058,"height":414},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24f6a141d59e441f9b303972f782c70d","type":"table_column","conversion_output":false,"parent_id":"48061cbefa8b422099610ce810a15bf3","text":"","text_display":""},{"cnt":[[124,175],[1999,175],[1999,580],[124,580]],"region":{"top_left_x":124,"top_left_y":175,"width":1876,"height":406},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"308ff0d6ff4b470ab171fa5f83229b27","type":"table_row","conversion_output":false,"parent_id":"48061cbefa8b422099610ce810a15bf3","text":"","text_display":""},{"cnt":[[146,180],[338,180],[338,260],[146,260]],"region":{"top_left_x":145,"top_left_y":179,"width":194,"height":81},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1ced97af5e94bddbfd3d64b06800a22","type":"complex_cell","conversion_output":false,"parent_id":"48061cbefa8b422099610ce810a15bf3","children_ids":["2fe07b82d3c344a4a1a818c66ebb12af","28e241c8a16a40e284a35225b7332d14"],"text":"Version 4.0.1 (3/18/14)","text_display":"Version 4.0.1 (3/18/14)","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[150,180],[338,180],[338,212],[150,212]],"region":{"top_left_x":149,"top_left_y":179,"width":190,"height":34},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fe07b82d3c344a4a1a818c66ebb12af","type":"text","conversion_output":false,"parent_id":"e1ced97af5e94bddbfd3d64b06800a22","text":"Version 4.0.1","text_display":"Version 4.0.1","confidence":1,"confidence_rate":1},{"cnt":[[150,219],[282,219],[282,260],[150,260]],"region":{"top_left_x":149,"top_left_y":218,"width":134,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28e241c8a16a40e284a35225b7332d14","type":"text","conversion_output":false,"parent_id":"e1ced97af5e94bddbfd3d64b06800a22","text":"(3/18/14)","text_display":" (3/18/14)","confidence":1,"confidence_rate":1},{"cnt":[[401,180],[707,180],[707,216],[401,216]],"region":{"top_left_x":401,"top_left_y":179,"width":306,"height":38},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce892f5b65954537845771cd7fc806c5","type":"simple_cell","conversion_output":false,"parent_id":"48061cbefa8b422099610ce810a15bf3","text":"8.2, 11.5, and Table 3","text_display":"8.2, 11.5, and Table 3","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[897,177],[1947,177],[1947,576],[897,576]],"region":{"top_left_x":897,"top_left_y":177,"width":1051,"height":399},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5061f76076c4f49b11c6e38dc11b0b4","type":"complex_cell","conversion_output":false,"parent_id":"48061cbefa8b422099610ce810a15bf3","children_ids":["ec1cb5421f36450eaf183579a8326bfa","a719cb4f102f4585ba2856ffabbb4d0e","164ea972f5f8432a8baeb2178208f92d","5995647a65dd4f139214b06b1ebdbb71","025a56dc8e3e4a19a36b879997dd3a11","1cf0c09ffca446e088e210a85d212b15","72f465d0e42a4334828abd3d34d90e59","02430338b6dd4c5eae06e848b1226130","bcbc5b86f50543a8bb473c43edb41ae2","1d716b2da51d47058f84512245a3a050"],"text":"We have added 2 out-of-window time intervals in order to collect data for the 16 - and 40-week follow-up visits outside the allowable window. The first out-of-window interval is 18-38 weeks post-randomization, which covers the period from the latest date for the 16-week visit to the earliest date for the 40-week visit. The second out-of-window interval is 44-68 weeks post-randomization, which covers the period from the latest date for the 40 -week visit to 24 weeks later. Although assessment visits are always done as close as possible to the target date, this change will increase the probability of obtaining complete follow-up data, even for participants whose assessments are difficult to schedule.","text_display":"We have added 2 out-of-window time intervals in order to collect data for the 16 - and 40-week follow-up visits outside the allowable window. The first out-of-window interval is 18-38 weeks post-randomization, which covers the period from the latest date for the 16-week visit to the earliest date for the 40-week visit. The second out-of-window interval is 44-68 weeks post-randomization, which covers the period from the latest date for the 40 -week visit to 24 weeks later. Although assessment visits are always done as close as possible to the target date, this change will increase the probability of obtaining complete follow-up data, even for participants whose assessments are difficult to schedule.","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.5938261151313782,"confidence_rate":0.9993243294154097},{"cnt":[[899,180],[1932,180],[1932,212],[899,212]],"region":{"top_left_x":899,"top_left_y":179,"width":1034,"height":34},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec1cb5421f36450eaf183579a8326bfa","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"We have added 2 out-of-window time intervals in order to collect data for","text_display":"We have added 2 out-of-window time intervals in order to collect data for","confidence":1,"confidence_rate":1},{"cnt":[[899,219],[1921,219],[1921,260],[899,260]],"region":{"top_left_x":899,"top_left_y":218,"width":1023,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a719cb4f102f4585ba2856ffabbb4d0e","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"the 16 - and 40-week follow-up visits outside the allowable window. The","text_display":" the 16 - and 40-week follow-up visits outside the allowable window. The","confidence":0.5938261151313782,"confidence_rate":0.9934246402780025},{"cnt":[[899,260],[1893,260],[1893,299],[899,299]],"region":{"top_left_x":899,"top_left_y":259,"width":995,"height":40},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"164ea972f5f8432a8baeb2178208f92d","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"first out-of-window interval is 18-38 weeks post-randomization, which","text_display":" first out-of-window interval is 18-38 weeks post-randomization, which","confidence":0.9912109375,"confidence_rate":0.9998807109786962},{"cnt":[[899,299],[1915,299],[1915,338],[899,338]],"region":{"top_left_x":899,"top_left_y":298,"width":1016,"height":40},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5995647a65dd4f139214b06b1ebdbb71","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"covers the period from the latest date for the 16-week visit to the earliest","text_display":" covers the period from the latest date for the 16-week visit to the earliest","confidence":0.99951171875,"confidence_rate":0.9999939703823991},{"cnt":[[899,336],[1893,336],[1893,375],[899,375]],"region":{"top_left_x":899,"top_left_y":335,"width":995,"height":40},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"025a56dc8e3e4a19a36b879997dd3a11","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"date for the 40-week visit. The second out-of-window interval is 44-68","text_display":" date for the 40-week visit. The second out-of-window interval is 44-68","confidence":0.99853515625,"confidence_rate":0.9999804546219134},{"cnt":[[899,375],[1945,375],[1945,418],[899,418]],"region":{"top_left_x":899,"top_left_y":374,"width":1047,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cf0c09ffca446e088e210a85d212b15","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"weeks post-randomization, which covers the period from the latest date for","text_display":" weeks post-randomization, which covers the period from the latest date for","confidence":1,"confidence_rate":1},{"cnt":[[899,418],[1941,418],[1941,459],[899,459]],"region":{"top_left_x":899,"top_left_y":417,"width":1042,"height":43},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72f465d0e42a4334828abd3d34d90e59","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"the 40 -week visit to 24 weeks later. Although assessment visits are always","text_display":" the 40 -week visit to 24 weeks later. Although assessment visits are always","confidence":0.99853515625,"confidence_rate":0.999982954590827},{"cnt":[[899,457],[1902,457],[1902,498],[899,498]],"region":{"top_left_x":899,"top_left_y":456,"width":1003,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02430338b6dd4c5eae06e848b1226130","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"done as close as possible to the target date, this change will increase the","text_display":" done as close as possible to the target date, this change will increase the","confidence":1,"confidence_rate":1},{"cnt":[[899,496],[1889,496],[1889,537],[899,537]],"region":{"top_left_x":899,"top_left_y":495,"width":990,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcbc5b86f50543a8bb473c43edb41ae2","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"probability of obtaining complete follow-up data, even for participants","text_display":" probability of obtaining complete follow-up data, even for participants","confidence":1,"confidence_rate":1},{"cnt":[[899,537],[1516,537],[1516,572],[899,572]],"region":{"top_left_x":899,"top_left_y":536,"width":618,"height":36},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d716b2da51d47058f84512245a3a050","type":"text","conversion_output":false,"parent_id":"b5061f76076c4f49b11c6e38dc11b0b4","text":"whose assessments are difficult to schedule.","text_display":" whose assessments are difficult to schedule.","confidence":1,"confidence_rate":1},{"cnt":[[516,619],[1609,619],[1609,677],[516,677]],"region":{"top_left_x":515,"top_left_y":618,"width":1095,"height":59},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfcb400386884c66be83be9300e12817","type":"figure_label","conversion_output":false,"text":"Summary of Modifications to Protocol Version 3.0 for Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[125,692],[2002,692],[2002,2099],[125,2099]],"region":{"top_left_x":124,"top_left_y":691,"width":1879,"height":1409},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb41e461c9334a32b12a109ba3693400","type":"table","conversion_output":true,"children_ids":["3d6c1abb9fc44f0b9e85bd905d76faf3","e367fc127e4e4d77a14adc3e65798cfd","a3585f63e0c040c3bfb43b073e5d2c75","d31997aef3414e8c895f922dde8fdbe6","2566aae1648a45df9a4f370e30938851","4cc2466b0f0b4df1b05079c050d59698","6b8fc62aaa30434692e7824a62819d58","2b153eae1db0499393765ae40039788f","1e16c1525070420e9701467790a45436","3163ac0d251940f69c96dbd84a412e34","5108e02817b443b09e3fb816111b3526","73f5711247c941159c7ea31b373697f8","80d315d6b60240bbb07dbad496f0dd2d","36ec195e7b734b36b0b30ca34fa43796","0c8523143d964e92af3a56fe4027b002","86b78b2bd9264446a4aad55c070c7b67","79e76dfef98e4efc8e2f51ca6da82795","59e12f521f7c481ea740221ac34d5fdc","62da2b8ca88d4b289757c4b124e189c0","fedb1ade7264427494dd05ee50cc09d8","eee8bfa2f22d428d935765a502b0d4ae","ebbe9deb5d4f42d48e68f9dbd377be62","97290a5ce7f0461584f7332ae184dbf1","4efeabefd796481c8f6b912704f8de3b","9ee63d46f5704150aa2b81f6b0f53083","626cbd9eef364fe19c0918b120a1544a","0c3f73099ff843829462a1ca1a072781","f1ebb68763954d4581615b87002fe254","016c36fe367449f78d12bc8f585217ef","f8698484be2a4cbea1ef905b0271c4c2","c2815a79057044319b7bf4802399ce70","01e0478e8d9148908c72f94233a854ae","9c978181456e434f9bb2d19be51d4e12","a017d234d3a04db0a6a172a19875b653","7a9707dec0e6469d94762fc063a7682e","2f28608fa79c4e8ebce1d1bdcf877756","1d79b9454277470ea3241195d01bd1a9","7dd61a5236f4413a87c9b8f4c78d4acb","ac208f41d2c14c63b08845460be3b751","b94405f27bac415a8ea89340d92a9265","41ebbeaab8584d36986e73c538763574","8294a4b964234893b82c25b8cfb4b0f4","70e81a03b50945efb6e6da156ea8ac13"],"selected_labels":["cfcb400386884c66be83be9300e12817"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Version (date) & Section & Brief Summary of Modification \\\\\n\\hline Version 4.0 (2/28/14) & All sections & In consultation with our Clinical Direction Committee, we are allowing other medical professionals who can function autonomously (not under physician supervision) to perform study activities related to evaluating medical eligibility, safety and reviewing RAEs. This will vary according to state regulations. This will facilitate clinical sites' access to appropriate clinicians who are available for time-sensitive activities. Clinical Site Physician has been replaced with Clinical Site Clinician throughout the protocol. \\\\\n\\hline Version 4.0 (2/28/14) & Executive Summary & Changes were made to the text to clarify that nutritional counseling will be provided to ensure adequate nutrient intake of \\(1.2-1.5 g\\) protein \\(/ kg\\) body weight inclusive of a healthy diet. \\\\\n\\hline Version 4.0 (2/28/14) & Table 1 & Minor editorial changes were made to the eligibility criteria for clarity. \\\\\n\\hline Version 4.0 (2/28/14) & Table 3 & The allowable interval of telephone interviews has been widened. The telephone interview can occur up to one week prior and up to three weeks after the target date. \\\\\n\\hline Version 4.0 (2/28/14) & 10.3.3 & A minor editorial change has been made for clarity. For the quadriceps strength test, the participant is not seated on the dynamometer; s/he is seated on the strength testing chair. \\\\\n\\hline Version 4.0 (2/28/14) & 8.2, 11.5, and Table 3 & We have added 2 out-of-window time intervals in order to collect data for the 16- and 40-week follow-up visits beyond the allowable window without resulting in a protocol deviation. The first out-of-window interval is between 18-38 weeks post-randomization, which covers the period from the maximum window for the 16 -week visit to the minimum data for the 40 week visit. The second out-of-window interval is up to 68 weeks postrandomization (6 months after the maximum date for the 40-week visit). \\\\\n\\hline Version 4.0 (2/28/14) & 13.2.3 and 13.4.3 & Updated text to include review of RAEs for ancillary studies to CAP. \\\\\n\\hline Version 4.0 (2/28/14) & 13.6 and 13.6.1 & Minor editorial changes were made to expand the categories for RAE status and actions taken in response to the RAE. \\\\\n\\hline Version 4.0 (2/28/14) & 20 & Updates made to the Study Team Roster. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Summary of Modifications to Protocol Version 3.0 for Version 4.0}\n\\begin{tabular}{|l|l|l|}\n\\hline Version (date) & Section & Brief Summary of Modification \\\\\n\\hline Version 4.0 (2/28/14) & All sections & In consultation with our Clinical Direction Committee, we are allowing other medical professionals who can function autonomously (not under physician supervision) to perform study activities related to evaluating medical eligibility, safety and reviewing RAEs. This will vary according to state regulations. This will facilitate clinical sites' access to appropriate clinicians who are available for time-sensitive activities. Clinical Site Physician has been replaced with Clinical Site Clinician throughout the protocol. \\\\\n\\hline Version 4.0 (2/28/14) & Executive Summary & Changes were made to the text to clarify that nutritional counseling will be provided to ensure adequate nutrient intake of \\(1.2-1.5 g\\) protein \\(/ kg\\) body weight inclusive of a healthy diet. \\\\\n\\hline Version 4.0 (2/28/14) & Table 1 & Minor editorial changes were made to the eligibility criteria for clarity. \\\\\n\\hline Version 4.0 (2/28/14) & Table 3 & The allowable interval of telephone interviews has been widened. The telephone interview can occur up to one week prior and up to three weeks after the target date. \\\\\n\\hline Version 4.0 (2/28/14) & 10.3.3 & A minor editorial change has been made for clarity. 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RAE reports and supporting documents sent to the ISM will be redacted to conceal treatment assignment.","text_display":"Changes were made to this section to indicate that the responsibility for determining relatedness of RAEs will entirely be the responsibility of the independent safety monitor (ISM), who will remain blinded. RAE reports and supporting documents sent to the ISM will be redacted to conceal treatment assignment.","cell_row":5,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[897,2166],[1904,2166],[1904,2207],[897,2207]],"region":{"top_left_x":897,"top_left_y":2166,"width":1008,"height":42},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9eb7642f005849d4807ce9175f170061","type":"text","conversion_output":false,"parent_id":"43b5af0a65214cd79c9a77d2ca19de26","text":"Changes were made to this section to indicate that the responsibility for","text_display":"Changes were made to this section to indicate that the responsibility for","confidence":1,"confidence_rate":1},{"cnt":[[897,2205],[1926,2205],[1926,2251],[897,2251]],"region":{"top_left_x":897,"top_left_y":2205,"width":1029,"height":46},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb87211244024e858a1577f062d38f9d","type":"text","conversion_output":false,"parent_id":"43b5af0a65214cd79c9a77d2ca19de26","text":"determining relatedness of RAEs will entirely be the responsibility of the","text_display":" determining relatedness of RAEs will entirely be the responsibility of the","confidence":1,"confidence_rate":1},{"cnt":[[897,2244],[1943,2244],[1943,2290],[897,2290]],"region":{"top_left_x":897,"top_left_y":2244,"width":1047,"height":46},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c44ec6948fb54ca0aa44b1c05bd7ede7","type":"text","conversion_output":false,"parent_id":"43b5af0a65214cd79c9a77d2ca19de26","text":"independent safety monitor (ISM), who will remain blinded. RAE reports","text_display":" independent safety monitor (ISM), who will remain blinded. RAE reports","confidence":1,"confidence_rate":1},{"cnt":[[897,2288],[1878,2288],[1878,2329],[897,2329]],"region":{"top_left_x":897,"top_left_y":2287,"width":982,"height":42},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2faf6dc336284e4abe24de2bc5193202","type":"text","conversion_output":false,"parent_id":"43b5af0a65214cd79c9a77d2ca19de26","text":"and supporting documents sent to the ISM will be redacted to conceal","text_display":" and supporting documents sent to the ISM will be redacted to conceal","confidence":1,"confidence_rate":1},{"cnt":[[897,2327],[1211,2327],[1211,2368],[897,2368]],"region":{"top_left_x":897,"top_left_y":2326,"width":315,"height":42},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42c2ab59d5674629ad1640c4546f2ab5","type":"text","conversion_output":false,"parent_id":"43b5af0a65214cd79c9a77d2ca19de26","text":"treatment assignment.","text_display":" treatment assignment.","confidence":1,"confidence_rate":1},{"cnt":[[509,2449],[1618,2449],[1618,2512],[509,2512]],"region":{"top_left_x":509,"top_left_y":2449,"width":1109,"height":63},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc7b778918ce4b059daa50d4f16d24b5","type":"section_header","conversion_output":false,"children_ids":["126868191d004ee08524607378896bcb"],"text":"","text_display":""},{"cnt":[[520,2454],[1609,2454],[1609,2503],[520,2503]],"region":{"top_left_x":519,"top_left_y":2453,"width":1091,"height":50},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"126868191d004ee08524607378896bcb","type":"text","conversion_output":true,"parent_id":"bc7b778918ce4b059daa50d4f16d24b5","text":"Summary of Modifications to Protocol Version 1.3 for Version 2.0","text_display":"\n\n\\section*{Summary of Modifications to Protocol Version 1.3 for Version 2.0}","confidence":0.99658203125,"confidence_rate":0.9999517782986254},{"cnt":[[125,2522],[2004,2522],[2004,2640],[125,2640]],"region":{"top_left_x":124,"top_left_y":2522,"width":1881,"height":119},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b8da44d0e574e83baf6f93f2515b665","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\begin{tabular}{l} \nVersion \\\\\n(date)\n\\end{tabular} & Section & Brief Summary of Modification \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\begin{tabular}{l} \nVersion \\\\\n(date)\n\\end{tabular} & Section & Brief Summary of Modification 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Version 2.0 (10/31/12) & All sections & Minor editorial changes and corrections were made throughout the document for clarity and consistency with the MOP. These changes can be seen with Track Changes. All significant changes are summarized in the remaining sections of this table. \\\\\n\\hline Version 2.0 (10/31/12) & All sections & Changes were made to the naming of the physical therapy interventions. \"Shuttle Plus\" is now PUSH. \"TENS Plus\" is now PULSE. We wanted to use names for the interventions that did not include the device name and that would be more meaningful and easy for the participants to remember. \\\\\n\\hline Version 2.0 (10/31/12) & All sections & In the original proposal, data capture, data management, and randomization were to be implemented by the Veterans Administration Cooperative Studies Program Coordinating Center (CSPCC) in Perry Point, MD. However, because of administrative and regulatory changes at the CSPCC, it was necessary to identify a different data group to handle these tasks. We have contracted with Axio Research, LLC (Seattle, WA) to provide data services. Throughout the current protocol version, \"CSPCC\" has been changed to \"Axio Research, LLC\" or \"Axio\" to reflect this change. References to DataFax (the data capture system that was proposed in the original protocol) have been removed to reflect the change to paper- and web-based data entry. \\\\\n\\hline Version 2.0 (10/31/12) & All sections & The name of the administrative database clinical sites will use to facilitate study management activities was changed from \"tracking database\" to \"study management database\" to more accurately reflect its role. \\\\\n\\hline Version 2.0 (10/31/12) & 6.2 & The section on randomization has been revised in light of modified procedures related to change to Axio as provider of data services. \\\\\n\\hline Version 2.0 (10/31/12) & 6.2 & \"The date and time of randomization is the time of study entry for each participant\" was changed to \"The date of randomization will mark the start of follow-up for each participant\". This correction was made to avoid contradicting the statement that \"Date of enrollment in the trial is defined as the date of informed consent\" (7.6.1). \\\\\n\\hline Version 2.0 (10/31/12) & 7.1 (Figure 2) & The algorithm for screening was updated to include correct terminology for the blood values for eligibility. \\\\\n\\hline Version 2.0 (10/31/12) & 7.3 and Table 1 & \\begin{tabular}{l}\nThese were updated to include newly added exclusion criteria (4.6, 4.7, 4.8 and 4.9). The new items are mostly administrative in nature, but need to be included as reasons why someone is not eligible. \\\\\nA correction was made to item 5.18. The gait speed is still the same, but it is based on walking less than 4 meters in 40 seconds.\n\\end{tabular} \\\\\n\\hline Version 2.0 (10/31/12) & 9.5.3 and 10.6.1 & We have added Polar heart rate monitoring to our Treatment Fidelity Plan. This will allow us to monitor the physiologic response during the intervention sessions for all participants. \\\\\n\\hline Version 2.0 (10/31/12) & 10.3.5 & The distance of the fast walking speed test was corrected from 50 m to 50 ft . \\\\\n\\hline Version 2.0 (10/31/12) & 11.1 (Table 2) & Table 2 was updated to reflect the current data collection form names and to delineate which assessments will be collected on paper forms and which will be submitted via web-entry. \\\\\n\\hline Version 2.0 (10/31/12) & 11.5 and Figure 4 & \\begin{tabular}{l}\nThe process for adjudication of the primary outcome has been modified. The emphasis in the revised adjudication process is on reducing the number of participants with a missing primary outcome by assigning treatment failure status to participants with a high probability of being unable to walk at least 300 m in six seconds. \\\\\nFigure 4 has been revised to correspond to the modified adjudication process.\n\\end{tabular} \\\\\n\\hline Version 2.0 (10/31/12)) & 13 & Minor editorial changes were made throughout this section to ensure consistency with our definitions of reportable adverse events versus expected adverse events, \\\\\n\\hline Version 2.0 (10/31/12) & 15.1 & The analysis plan was modified to reflect changes in the adjudication procedure. \\\\\n\\hline Version 2.0 (10/31/12) & 16.1, 16.2, 16.3, 16.4 & The sections on data capture, data management, and data security have been revised in light of modified procedures related to change to Axio as provider of data services. \\\\\n\\hline Version 2.0 (10/31/12) & 20 & Updates made to the Study Team Roster. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version 2.0 (10/31/12) & All sections & Minor editorial changes and corrections were made throughout the document for clarity and consistency with the MOP. These changes can be seen with Track Changes. All significant changes are summarized in the remaining sections of this table. \\\\\n\\hline Version 2.0 (10/31/12) & All sections & Changes were made to the naming of the physical therapy interventions. \"Shuttle Plus\" is now PUSH. \"TENS Plus\" is now PULSE. We wanted to use names for the interventions that did not include the device name and that would be more meaningful and easy for the participants to remember. \\\\\n\\hline Version 2.0 (10/31/12) & All sections & In the original proposal, data capture, data management, and randomization were to be implemented by the Veterans Administration Cooperative Studies Program Coordinating Center (CSPCC) in Perry Point, MD. However, because of administrative and regulatory changes at the CSPCC, it was necessary to identify a different data group to handle these tasks. We have contracted with Axio Research, LLC (Seattle, WA) to provide data services. Throughout the current protocol version, \"CSPCC\" has been changed to \"Axio Research, LLC\" or \"Axio\" to reflect this change. References to DataFax (the data capture system that was proposed in the original protocol) have been removed to reflect the change to paper- and web-based data entry. \\\\\n\\hline Version 2.0 (10/31/12) & All sections & The name of the administrative database clinical sites will use to facilitate study management activities was changed from \"tracking database\" to \"study management database\" to more accurately reflect its role. \\\\\n\\hline Version 2.0 (10/31/12) & 6.2 & The section on randomization has been revised in light of modified procedures related to change to Axio as provider of data services. \\\\\n\\hline Version 2.0 (10/31/12) & 6.2 & \"The date and time of randomization is the time of study entry for each participant\" was changed to \"The date of randomization will mark the start of follow-up for each participant\". This correction was made to avoid contradicting the statement that \"Date of enrollment in the trial is defined as the date of informed consent\" (7.6.1). \\\\\n\\hline Version 2.0 (10/31/12) & 7.1 (Figure 2) & The algorithm for screening was updated to include correct terminology for the blood values for eligibility. \\\\\n\\hline Version 2.0 (10/31/12) & 7.3 and Table 1 & \\begin{tabular}{l}\nThese were updated to include newly added exclusion criteria (4.6, 4.7, 4.8 and 4.9). The new items are mostly administrative in nature, but need to be included as reasons why someone is not eligible. \\\\\nA correction was made to item 5.18. The gait speed is still the same, but it is based on walking less than 4 meters in 40 seconds.\n\\end{tabular} \\\\\n\\hline Version 2.0 (10/31/12) & 9.5.3 and 10.6.1 & We have added Polar heart rate monitoring to our Treatment Fidelity Plan. This will allow us to monitor the physiologic response during the intervention sessions for all participants. \\\\\n\\hline Version 2.0 (10/31/12) & 10.3.5 & The distance of the fast walking speed test was corrected from 50 m to 50 ft . \\\\\n\\hline Version 2.0 (10/31/12) & 11.1 (Table 2) & Table 2 was updated to reflect the current data collection form names and to delineate which assessments will be collected on paper forms and which will be submitted via web-entry. \\\\\n\\hline Version 2.0 (10/31/12) & 11.5 and Figure 4 & \\begin{tabular}{l}\nThe process for adjudication of the primary outcome has been modified. The emphasis in the revised adjudication process is on reducing the number of participants with a missing primary outcome by assigning treatment failure status to participants with a high probability of being unable to walk at least 300 m in six seconds. \\\\\nFigure 4 has been revised to correspond to the modified adjudication process.\n\\end{tabular} \\\\\n\\hline Version 2.0 (10/31/12)) & 13 & Minor editorial changes were made throughout this section to ensure consistency with our definitions of reportable adverse events versus expected adverse events, \\\\\n\\hline Version 2.0 (10/31/12) & 15.1 & The analysis plan was modified to reflect changes in the adjudication procedure. \\\\\n\\hline Version 2.0 (10/31/12) & 16.1, 16.2, 16.3, 16.4 & The sections on data capture, data management, and data security have been revised in light of modified procedures related to change to Axio as provider of data services. \\\\\n\\hline Version 2.0 (10/31/12) & 20 & Updates made to the Study Team 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day),","confidence":0.5229263305664062,"confidence_rate":0.9926598590674834},{"cnt":[[899,2348],[1651,2348],[1651,2389],[899,2389]],"region":{"top_left_x":899,"top_left_y":2348,"width":752,"height":42},"line":170,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2567340d323f45a186c513909d469412","type":"text","conversion_output":false,"parent_id":"447fd5116b42442f9f8ecd28710eb7ad","text":"to 600 mg once a day as per DSMB recommendation.","text_display":" to 600 mg once a day as per DSMB 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If a participant has a serum albumin level 2.5-","text_display":" Clinical Direction Committee. 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Version 1.1 (1/26/2012) & 3.1.6 (DCC) & Added \"...implement the data analysis plan\" to DCC's list of responsibilities. \\\\\n\\hline Version 1.1 (1/26/2012) & 3.2.3, 12.1.7 & Added calculated creatinine clearance \\(<30 ml / min\\) obtained from blood draw as a contraindication for calcium supplementation. Participants with contraindications for calcium will receive vitamin D and multivitamin. \\\\\n\\hline Version 1.1 (1/26/2012) & 6.1 (Figure 1) & Included revised Figure 1 for clarity. \\\\\n\\hline Version 1.1 (1/26/2012) & 4.2 & Corrected an error. \"...following initiation of the intervention\" was replaced by \"...following randomization.\" \\\\\n\\hline Version 1.1 (1/26/2012) & 7.1, 10.1, 11.4 (Table 3) & Based on the DSMB's recommendations, we have added three exclusion criteria: hemoglobin \\(<9 g / dl\\), calculated creatinine clearance \\(<15 ml / min\\), and serum albumin \\(<2.5 g / dl\\). The blood can be obtained between phases 2 and 3, but no more than 4 weeks prior to randomization. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.1 & Updated Figure 2 incorporating the blood draw and additional exclusion criteria and possibility of phase 2 being an in-person visit. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.1, 7.5, 7.6, 17.2 & We are no longer requiring that informed consent be obtained at the baseline visit (phase 3 screening). For greater flexibility and to maximize enrollment, we are now allowing informed consent to be obtained at any time prior to data collection that is not covered by the HIPAA Partial Privacy Waiver. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 3) & Edited item for clarity. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 3.3) & Moved this item from eligibility section 5 since it is defining our target population. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 5.1) & As per DSMB, added new exclusion criterion of calculated creatinine clearance \\(<15 ml / min\\) as a medical impediment to participation. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 5.2) & As per DSMB, added new exclusion criterion of serum albumin \\(<2.5 g / dl\\) as a medical impediment to participation. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 5.5) & Deleted \"legally blind\" since we capture this in criterion 5.4 (severe sensory impairment (visual or hearing)). \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 5.7) & \"History of Parkinson's disease, multiple sclerosis....\" moved from eligibility section 6 since the criterion captures medical impediments to participation. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 6.1) & As per DSMB, added new exclusion criterion of hemoglobin \\(<9 g / dl\\) for safety. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 7) & Edited the category so that it is just contraindications for calcium supplementation. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 7.2) & Deleted glomerular filtration rate ( \\(<30 ml / min\\) ) obtained from the medical chart since we are now obtaining a calculated creatinine clearance from blood drawn within 4 weeks prior to randomization. A calculated creatinine clearance \\(<30 ml / min\\) will be a contraindication for receiving calcium supplementation. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 8) & Deleted \"Other\" as a criterion. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (Table 1) & Edited Table 1 to reflect all changes to the eligibility criteria. \\\\\n\\hline Version 1.1 (1/26/2012) & 9.2, 10.6.1, 11.3 & Previously, we planned to assess adherence to study medications only during the 16-week intervention period. We now propose to also assess adherence to study medications during the 24-week post-intervention period using self-report questions administered during the 4-week phone calls. \\\\\n\\hline Version 1.1 (1/26/2012) & 10.1.1 & Correction: Height will be measured in feet and inches and weight will be measured in pounds. \\\\\n\\hline Version 1.1 (1/26/2012) & 10.3.2 & Added clarification on the scoring of the balance measure. \\\\\n\\hline Version 1.1 (1/26/2012) & 10.3.5 & Clarified that the time required to walk 50 meters is the measure for fast walking speed. \\\\\n\\hline Version 1.1 (1/26/2012) & 10.4.6 & Removed incorrect statement about summing the scores for obtaining the standing balance subscale. \\\\\n\\hline Version 1.1 (1/26/2012) & 11 (Table 2) & Updated the table to reflect the timing of informed consent, addition of a blood draw, and assessment of adherence to study medications beyond intervention period. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Version 1.1 (1/26/2012) & 3.1.6 (DCC) & Added \"...implement the data analysis plan\" to DCC's list of responsibilities. \\\\\n\\hline Version 1.1 (1/26/2012) & 3.2.3, 12.1.7 & Added calculated creatinine clearance \\(<30 ml / min\\) obtained from blood draw as a contraindication for calcium supplementation. Participants with contraindications for calcium will receive vitamin D and multivitamin. \\\\\n\\hline Version 1.1 (1/26/2012) & 6.1 (Figure 1) & Included revised Figure 1 for clarity. \\\\\n\\hline Version 1.1 (1/26/2012) & 4.2 & Corrected an error. \"...following initiation of the intervention\" was replaced by \"...following randomization.\" \\\\\n\\hline Version 1.1 (1/26/2012) & 7.1, 10.1, 11.4 (Table 3) & Based on the DSMB's recommendations, we have added three exclusion criteria: hemoglobin \\(<9 g / dl\\), calculated creatinine clearance \\(<15 ml / min\\), and serum albumin \\(<2.5 g / dl\\). The blood can be obtained between phases 2 and 3, but no more than 4 weeks prior to randomization. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.1 & Updated Figure 2 incorporating the blood draw and additional exclusion criteria and possibility of phase 2 being an in-person visit. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.1, 7.5, 7.6, 17.2 & We are no longer requiring that informed consent be obtained at the baseline visit (phase 3 screening). For greater flexibility and to maximize enrollment, we are now allowing informed consent to be obtained at any time prior to data collection that is not covered by the HIPAA Partial Privacy Waiver. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 3) & Edited item for clarity. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 3.3) & Moved this item from eligibility section 5 since it is defining our target population. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 5.1) & As per DSMB, added new exclusion criterion of calculated creatinine clearance \\(<15 ml / min\\) as a medical impediment to participation. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 5.2) & As per DSMB, added new exclusion criterion of serum albumin \\(<2.5 g / dl\\) as a medical impediment to participation. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 5.5) & Deleted \"legally blind\" since we capture this in criterion 5.4 (severe sensory impairment (visual or hearing)). \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 5.7) & \"History of Parkinson's disease, multiple sclerosis....\" moved from eligibility section 6 since the criterion captures medical impediments to participation. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 6.1) & As per DSMB, added new exclusion criterion of hemoglobin \\(<9 g / dl\\) for safety. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 7) & Edited the category so that it is just contraindications for calcium supplementation. \\\\\n\\hline Version 1.1 (1/26/2012) & 7.2 (criterion 7.2) & Deleted glomerular filtration rate ( \\(<30 ml / min\\) ) obtained from the medical chart since we are now obtaining a calculated creatinine clearance from blood drawn within 4 weeks prior to randomization. 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The new time windows reflect that each can occur between 4-14 weeks post-admission","text_display":"With the addition of the blood, the timing of informed consent and phase 2 screening has been widened. The new time windows reflect that each can occur between 4-14 weeks post-admission","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,197],[1945,197],[1945,241],[899,241]],"region":{"top_left_x":899,"top_left_y":197,"width":1047,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46db3103b54e4e7c8a96b7cebe58670b","type":"text","conversion_output":false,"parent_id":"913ef06858ff45e2bac61bfb415add7c","text":"With the addition of the blood, the timing of informed consent and phase 2","text_display":"With the addition of the blood, the timing of informed consent and phase 2","confidence":1,"confidence_rate":1},{"cnt":[[899,241],[1934,241],[1934,282],[899,282]],"region":{"top_left_x":899,"top_left_y":240,"width":1036,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa65b7acb8aa487ea3c0f431d0f9e491","type":"text","conversion_output":false,"parent_id":"913ef06858ff45e2bac61bfb415add7c","text":"screening has been widened. The new time windows reflect that each can","text_display":" screening has been widened. The new time windows reflect that each can","confidence":1,"confidence_rate":1},{"cnt":[[899,280],[1495,280],[1495,321],[899,321]],"region":{"top_left_x":899,"top_left_y":279,"width":596,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c72062dadd94a44a2b7479d472df206","type":"text","conversion_output":false,"parent_id":"913ef06858ff45e2bac61bfb415add7c","text":"occur between 4-14 weeks post-admission","text_display":" occur between 4-14 weeks post-admission","confidence":1,"confidence_rate":1},{"cnt":[[146,319],[319,319],[319,403],[146,403]],"region":{"top_left_x":145,"top_left_y":318,"width":174,"height":86},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cdd10d041d1a41ca9ae469696972057f","type":"complex_cell","conversion_output":false,"parent_id":"a39e0513d5694416944af999b9891240","children_ids":["d397434ec61f44a1a85260ac41bd5ceb","cbc4ab80d39c408390e199193692fff9"],"text":"Version 1.1 (1/26/2012)","text_display":"Version 1.1 (1/26/2012)","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[150,323],[312,323],[312,355],[150,355]],"region":{"top_left_x":149,"top_left_y":322,"width":164,"height":34},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d397434ec61f44a1a85260ac41bd5ceb","type":"text","conversion_output":false,"parent_id":"cdd10d041d1a41ca9ae469696972057f","text":"Version 1.1","text_display":"Version 1.1","confidence":1,"confidence_rate":1},{"cnt":[[150,362],[317,362],[317,399],[150,399]],"region":{"top_left_x":149,"top_left_y":361,"width":168,"height":38},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbc4ab80d39c408390e199193692fff9","type":"text","conversion_output":false,"parent_id":"cdd10d041d1a41ca9ae469696972057f","text":"(1/26/2012)","text_display":" (1/26/2012)","confidence":1,"confidence_rate":1},{"cnt":[[403,323],[470,323],[470,358],[403,358]],"region":{"top_left_x":403,"top_left_y":322,"width":68,"height":36},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62bb5edb48ab4768a0f50e4c7ea73d13","type":"simple_cell","conversion_output":false,"parent_id":"a39e0513d5694416944af999b9891240","text":"11.5","text_display":"11.5","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[895,336],[1967,336],[1967,925],[895,925]],"region":{"top_left_x":894,"top_left_y":335,"width":1073,"height":590},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55c8ad2067c34802a8950feb83253a7d","type":"complex_cell","conversion_output":false,"parent_id":"a39e0513d5694416944af999b9891240","children_ids":["8fecb50002ca44288cd148d4555b89bf","57f043e3aa7f4ac897a3f2c358243458","03a219a2fd4f4e0cb6a6f9c861ba84a2","16aa23174ca041cd887916f963bb429c","6d2912eb17c4464e9ab7d3e0f282c2f0","5987011efa174504951455767649035f","fb09734c2a144986ba116232cf69da53","1e56f01d05994955904179f06e983b7d","de4b76ba604a43fbafb8ec9ca8946e2c","67aeaa6fa9ae442a8814f20a9376ff62","fcf12c8add804483a606c2795fc6cfb0","7d77141d069841c2b5d456a722632e38","ad8b2fd8edbb4e54800f70f0e5489cfb"],"text":"\\begin{tabular}{l}\nWe now require that the Six Minute Walk Test (SMWT) be administered only by study staff whereas previously we allowed administration by nonstudy staff. We have clarified that, at follow-up, self-report or proxy-report of walking ability will be used for participants who cannot perform the SMWT because of non-physical reasons (e.g., cognitive or sensory impairment). \\\\\nWe have clarified that our approach to classification will reduce bias by maximizing the number of participants who are included in the analysis for the primary outcome. \\\\\nWe have removed the sample self/proxy-report question that will be used to assess walking ability. The actual question will be added to the data collection forms and the Manual of Procedures. \\\\\nThe adjudication process has been clarified.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nWe now require that the Six Minute Walk Test (SMWT) be administered only by study staff whereas previously we allowed administration by nonstudy staff. We have clarified that, at follow-up, self-report or proxy-report of walking ability will be used for participants who cannot perform the SMWT because of non-physical reasons (e.g., cognitive or sensory impairment). \\\\\nWe have clarified that our approach to classification will reduce bias by maximizing the number of participants who are included in the analysis for the primary outcome. \\\\\nWe have removed the sample self/proxy-report question that will be used to assess walking ability. The actual question will be added to the data collection forms and the Manual of Procedures. \\\\\nThe adjudication process has been clarified.\n\\end{tabular}","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,342],[1924,342],[1924,381],[899,381]],"region":{"top_left_x":899,"top_left_y":342,"width":1025,"height":40},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fecb50002ca44288cd148d4555b89bf","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"We now require that the Six Minute Walk Test (SMWT) be administered","text_display":"We now require that the Six Minute Walk Test (SMWT) be administered","confidence":1,"confidence_rate":1},{"cnt":[[899,384],[1937,384],[1937,423],[899,423]],"region":{"top_left_x":899,"top_left_y":383,"width":1038,"height":40},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57f043e3aa7f4ac897a3f2c358243458","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"only by study staff whereas previously we allowed administration by non-","text_display":" only by study staff whereas previously we allowed administration by non","confidence":1,"confidence_rate":1},{"cnt":[[899,423],[1950,423],[1950,464],[899,464]],"region":{"top_left_x":899,"top_left_y":422,"width":1051,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03a219a2fd4f4e0cb6a6f9c861ba84a2","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"study staff. We have clarified that, at follow-up, self-report or proxy-report","text_display":"study staff. We have clarified that, at follow-up, self-report or proxy-report","confidence":1,"confidence_rate":1},{"cnt":[[899,464],[1893,464],[1893,503],[899,503]],"region":{"top_left_x":899,"top_left_y":463,"width":995,"height":40},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16aa23174ca041cd887916f963bb429c","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"of walking ability will be used for participants who cannot perform the","text_display":" of walking ability will be used for participants who cannot perform the","confidence":1,"confidence_rate":1},{"cnt":[[899,505],[1837,505],[1837,542],[899,542]],"region":{"top_left_x":899,"top_left_y":504,"width":938,"height":38},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d2912eb17c4464e9ab7d3e0f282c2f0","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"SMWT because of non-physical reasons (e.g., cognitive or sensory","text_display":" SMWT because of non-physical reasons (e.g., cognitive or sensory","confidence":1,"confidence_rate":1},{"cnt":[[899,544],[1083,544],[1083,585],[899,585]],"region":{"top_left_x":899,"top_left_y":543,"width":185,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5987011efa174504951455767649035f","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"impairment).","text_display":" impairment).","confidence":1,"confidence_rate":1},{"cnt":[[899,604],[1904,604],[1904,643],[899,643]],"region":{"top_left_x":899,"top_left_y":604,"width":1006,"height":40},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb09734c2a144986ba116232cf69da53","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"We have clarified that our approach to classification will reduce bias by","text_display":"\nWe have clarified that our approach to classification will reduce bias by","confidence":1,"confidence_rate":1},{"cnt":[[899,643],[1954,643],[1954,682],[899,682]],"region":{"top_left_x":899,"top_left_y":643,"width":1055,"height":40},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e56f01d05994955904179f06e983b7d","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"maximizing the number of participants who are included in the analysis for","text_display":" maximizing the number of participants who are included in the analysis for","confidence":1,"confidence_rate":1},{"cnt":[[899,682],[1202,682],[1202,724],[899,724]],"region":{"top_left_x":899,"top_left_y":682,"width":304,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de4b76ba604a43fbafb8ec9ca8946e2c","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"the primary outcome.","text_display":" the primary outcome.","confidence":1,"confidence_rate":1},{"cnt":[[899,743],[1963,743],[1963,784],[899,784]],"region":{"top_left_x":899,"top_left_y":743,"width":1064,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67aeaa6fa9ae442a8814f20a9376ff62","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"We have removed the sample self/proxy-report question that will be used to","text_display":"\nWe have removed the sample self/proxy-report question that will be used to","confidence":1,"confidence_rate":1},{"cnt":[[899,782],[1850,782],[1850,823],[899,823]],"region":{"top_left_x":899,"top_left_y":781,"width":951,"height":43},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fcf12c8add804483a606c2795fc6cfb0","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"assess walking ability. The actual question will be added to the data","text_display":" assess walking ability. The actual question will be added to the data","confidence":1,"confidence_rate":1},{"cnt":[[899,821],[1566,821],[1566,862],[899,862]],"region":{"top_left_x":899,"top_left_y":820,"width":668,"height":43},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d77141d069841c2b5d456a722632e38","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"collection forms and the Manual of Procedures.","text_display":" collection forms and the Manual of Procedures.","confidence":1,"confidence_rate":1},{"cnt":[[899,884],[1516,884],[1516,923],[899,923]],"region":{"top_left_x":899,"top_left_y":883,"width":618,"height":40},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad8b2fd8edbb4e54800f70f0e5489cfb","type":"text","conversion_output":false,"parent_id":"55c8ad2067c34802a8950feb83253a7d","text":"The adjudication process has been clarified.","text_display":"\nThe adjudication process has been clarified.","confidence":1,"confidence_rate":1},{"cnt":[[146,925],[319,925],[319,1007],[146,1007]],"region":{"top_left_x":145,"top_left_y":924,"width":174,"height":84},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"163b79583f2e44d99f51ba90b97dd9dc","type":"complex_cell","conversion_output":false,"parent_id":"a39e0513d5694416944af999b9891240","children_ids":["45387019404e4924a4176b4f8be5b17b","0ccf0c849f704438a0f605ed8ec9817a"],"text":"Version 1.1 (1/26/2012)","text_display":"Version 1.1 (1/26/2012)","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[150,929],[312,929],[312,962],[150,962]],"region":{"top_left_x":149,"top_left_y":929,"width":164,"height":33},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45387019404e4924a4176b4f8be5b17b","type":"text","conversion_output":false,"parent_id":"163b79583f2e44d99f51ba90b97dd9dc","text":"Version 1.1","text_display":"Version 1.1","confidence":1,"confidence_rate":1},{"cnt":[[150,968],[317,968],[317,1005],[150,1005]],"region":{"top_left_x":149,"top_left_y":968,"width":168,"height":38},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ccf0c849f704438a0f605ed8ec9817a","type":"text","conversion_output":false,"parent_id":"163b79583f2e44d99f51ba90b97dd9dc","text":"(1/26/2012)","text_display":" (1/26/2012)","confidence":1,"confidence_rate":1},{"cnt":[[403,925],[542,925],[542,966],[403,966]],"region":{"top_left_x":403,"top_left_y":924,"width":139,"height":43},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf37285480a848489c46dba526e80950","type":"simple_cell","conversion_output":false,"parent_id":"a39e0513d5694416944af999b9891240","text":"11.5, 15.1","text_display":"11.5, 15.1","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[897,925],[1982,925],[1982,1087],[897,1087]],"region":{"top_left_x":897,"top_left_y":924,"width":1085,"height":164},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da728b773f734d5db75dc6f0eb375102","type":"complex_cell","conversion_output":false,"parent_id":"a39e0513d5694416944af999b9891240","children_ids":["b1645bb13b6042b69efb510905bde437","105fc1a6323d452b877c36fdc0a49baa","f9481f07308c459ab0889f63d20f9f8b","31358e824ebd46d092bfb9f8a53670f0"],"text":"At follow-up, participants who cannot perform the SMWT because of illness, sickness, or death will be considered treatment failures in both the primary and secondary analyses. They were considered missing in secondary analysis in the previous version.","text_display":"At follow-up, participants who cannot perform the SMWT because of illness, sickness, or death will be considered treatment failures in both the primary and secondary analyses. They were considered missing in secondary analysis in the previous version.","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[899,925],[1880,925],[1880,966],[899,966]],"region":{"top_left_x":899,"top_left_y":924,"width":982,"height":43},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1645bb13b6042b69efb510905bde437","type":"text","conversion_output":false,"parent_id":"da728b773f734d5db75dc6f0eb375102","text":"At follow-up, participants who cannot perform the SMWT because of","text_display":"At follow-up, participants who cannot perform the SMWT because of","confidence":1,"confidence_rate":1},{"cnt":[[899,964],[1932,964],[1932,1005],[899,1005]],"region":{"top_left_x":899,"top_left_y":963,"width":1034,"height":43},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"105fc1a6323d452b877c36fdc0a49baa","type":"text","conversion_output":false,"parent_id":"da728b773f734d5db75dc6f0eb375102","text":"illness, sickness, or death will be considered treatment failures in both the","text_display":" illness, sickness, or death will be considered treatment failures in both the","confidence":1,"confidence_rate":1},{"cnt":[[899,1005],[1980,1005],[1980,1046],[899,1046]],"region":{"top_left_x":899,"top_left_y":1005,"width":1081,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9481f07308c459ab0889f63d20f9f8b","type":"text","conversion_output":false,"parent_id":"da728b773f734d5db75dc6f0eb375102","text":"primary and secondary analyses. They were considered missing in secondary","text_display":" primary and secondary analyses. They were considered missing in secondary","confidence":1,"confidence_rate":1},{"cnt":[[899,1046],[1352,1046],[1352,1087],[899,1087]],"region":{"top_left_x":899,"top_left_y":1046,"width":453,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31358e824ebd46d092bfb9f8a53670f0","type":"text","conversion_output":false,"parent_id":"da728b773f734d5db75dc6f0eb375102","text":"analysis in the previous version.","text_display":" analysis in the previous version.","confidence":1,"confidence_rate":1},{"cnt":[[146,1085],[317,1085],[317,1165],[146,1165]],"region":{"top_left_x":145,"top_left_y":1085,"width":172,"height":81},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6df98d476677417f8019aab36ad83ea5","type":"complex_cell","conversion_output":false,"parent_id":"a39e0513d5694416944af999b9891240","children_ids":["91456bdf24b146beb50b4bbbcc0fd1c2","a1b3f90da3fa4dc385f116d8ff234484"],"text":"Version 1.1 (1/26/2012)","text_display":"Version 1.1 (1/26/2012)","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[150,1089],[312,1089],[312,1122],[150,1122]],"region":{"top_left_x":149,"top_left_y":1089,"width":164,"height":33},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91456bdf24b146beb50b4bbbcc0fd1c2","type":"text","conversion_output":false,"parent_id":"6df98d476677417f8019aab36ad83ea5","text":"Version 1.1","text_display":"Version 1.1","confidence":1,"confidence_rate":1},{"cnt":[[148,1128],[317,1128],[317,1165],[148,1165]],"region":{"top_left_x":147,"top_left_y":1128,"width":170,"height":38},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1b3f90da3fa4dc385f116d8ff234484","type":"text","conversion_output":false,"parent_id":"6df98d476677417f8019aab36ad83ea5","text":"(1/26/2012)","text_display":" 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1: Executive Summary","text_display":"\n\n\\section*{Section 1: Executive Summary}","confidence":0.99951171875,"confidence_rate":0.9999852000944255},{"cnt":[[249,378],[1826,378],[1826,423],[249,423]],"region":{"top_left_x":249,"top_left_y":378,"width":1578,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78a0c9f2f32145768692e64b7a7ad96b","type":"text","conversion_output":true,"text":"Despite improvements in medical management, significant residual disability remains in older","text_display":"\n\nDespite improvements in medical management, significant residual disability remains in older","confidence":1,"confidence_rate":1},{"cnt":[[247,421],[1708,421],[1708,466],[247,466]],"region":{"top_left_x":247,"top_left_y":421,"width":1462,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"262bc774c5d444e4b9b6b1027b9b9602","type":"text","conversion_output":true,"text":"persons after a hip fracture. \\({ }^{1-3}\\) The goal of current clinical practice is independent, safe","text_display":" persons after a hip fracture. \\({ }^{1-3}\\) The goal of current clinical practice is independent, safe","confidence":1,"confidence_rate":1},{"cnt":[[247,464],[1858,464],[1858,509],[247,509]],"region":{"top_left_x":247,"top_left_y":464,"width":1612,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9afcda4f0f242afa3272c625b2bd6c2","type":"text","conversion_output":true,"text":"household ambulation two to three months after surgery. \\({ }^{4}\\) Hip fracture-acquired dependency in","text_display":" household ambulation two to three months after surgery. \\({ }^{4}\\) Hip fracture-acquired dependency in","confidence":1,"confidence_rate":1},{"cnt":[[247,507],[1794,507],[1794,552],[247,552]],"region":{"top_left_x":247,"top_left_y":507,"width":1547,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1eb1ef50a15642af86ad22ab9371a01a","type":"text","conversion_output":true,"text":"functional activities of daily living persists well beyond three months post-surgery. One year","text_display":" functional activities of daily living persists well beyond three months post-surgery. One year","confidence":1,"confidence_rate":1},{"cnt":[[247,554],[1876,554],[1876,595],[247,595]],"region":{"top_left_x":247,"top_left_y":554,"width":1629,"height":42},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1aac9407a3b42359e9a39edde60939a","type":"text","conversion_output":true,"text":"after hip fracture, \\(20 \\%\\) of patients need help putting on pants, \\(50 \\%\\) need assistance to walk, and","text_display":" after hip fracture, \\(20 \\%\\) of patients need help putting on pants, \\(50 \\%\\) need assistance to walk, and","confidence":0.83349609375,"confidence_rate":0.9982993331646437},{"cnt":[[247,595],[1803,595],[1803,640],[247,640]],"region":{"top_left_x":247,"top_left_y":595,"width":1556,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"867e628e45bc4870af2db4d863fecf1a","type":"text","conversion_output":true,"text":"\\(90 \\%\\) need assistance to climb stairs. \\({ }^{2}\\) This residual disability indicates that current standard","text_display":" \\(90 \\%\\) need assistance to climb stairs. \\({ }^{2}\\) This residual disability indicates that current standard","confidence":0.98974609375,"confidence_rate":0.9999054463080289},{"cnt":[[249,640],[1749,640],[1749,685],[249,685]],"region":{"top_left_x":249,"top_left_y":640,"width":1500,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac3e507ac4914f5689fc3310b0a2fec1","type":"text","conversion_output":true,"text":"Medicare-reimbursed post-hip fracture rehabilitation (i.e., usual care) fails to return many","text_display":" Medicare-reimbursed post-hip fracture rehabilitation (i.e., usual care) fails to return many","confidence":1,"confidence_rate":1},{"cnt":[[249,683],[1712,683],[1712,728],[249,728]],"region":{"top_left_x":249,"top_left_y":683,"width":1464,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"962562adfb154b1d9209c484ec7923da","type":"text","conversion_output":true,"text":"patients to pre-fracture levels of function. In contrast to stroke and heart disease, other","text_display":" patients to pre-fracture levels of function. In contrast to stroke and heart disease, other","confidence":1,"confidence_rate":1},{"cnt":[[249,730],[1811,730],[1811,771],[249,771]],"region":{"top_left_x":249,"top_left_y":730,"width":1563,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"778e43bad7d74531842bd5bf0ca02963","type":"text","conversion_output":true,"text":"commonly occurring acute conditions in the older population, there are few intervention trials","text_display":" commonly occurring acute conditions in the older population, there are few intervention trials","confidence":1,"confidence_rate":1},{"cnt":[[247,773],[1794,773],[1794,816],[247,816]],"region":{"top_left_x":247,"top_left_y":773,"width":1547,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"852ee5f3cc4747b991fe3f9330e4a4a2","type":"text","conversion_output":true,"text":"focused on decreasing disability following hip fracture. None of the trials for hip fracture has","text_display":" focused on decreasing disability following hip fracture. None of the trials for hip fracture has","confidence":1,"confidence_rate":1},{"cnt":[[247,816],[1755,816],[1755,862],[247,862]],"region":{"top_left_x":247,"top_left_y":816,"width":1509,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbef1a15a97a4cc18f128d1072611394","type":"text","conversion_output":true,"text":"examined the effect of early post-fracture intervention on the ability to ambulate at a level","text_display":" examined the effect of early post-fracture intervention on the ability to ambulate at a level","confidence":1,"confidence_rate":1},{"cnt":[[249,862],[1854,862],[1854,904],[249,904]],"region":{"top_left_x":249,"top_left_y":861,"width":1606,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b0cac1cf58d4d52a2055772fdd2323c","type":"text","conversion_output":true,"text":"required for independent function in the community (i.e., community ambulation). Thus, there is","text_display":" required for independent function in the community (i.e., community ambulation). Thus, there is","confidence":1,"confidence_rate":1},{"cnt":[[249,907],[1824,907],[1824,947],[249,947]],"region":{"top_left_x":249,"top_left_y":906,"width":1576,"height":42},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a33faeab7594fa58b253443763a0f2d","type":"text","conversion_output":true,"text":"a paucity of evidence to justify extending medical management beyond usual care in persons","text_display":" a paucity of evidence to justify extending medical management beyond usual care in persons","confidence":1,"confidence_rate":1},{"cnt":[[245,950],[1717,950],[1717,993],[245,993]],"region":{"top_left_x":244,"top_left_y":949,"width":1473,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84df3e9c534046dfafda51a4f1ebc654","type":"text","conversion_output":true,"text":"following hip fracture to achieve community, rather than merely household, ambulation.","text_display":" following hip fracture to achieve community, rather than merely household, ambulation.","confidence":1,"confidence_rate":1},{"cnt":[[245,1031],[449,1031],[449,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1031,"width":206,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59d0c3ec45334aea9627b5e82422fbfe","type":"section_header","conversion_output":false,"children_ids":["215ffe44f3734116974d591bbf919c20"],"text":"","text_display":""},{"cnt":[[249,1036],[449,1036],[449,1081],[249,1081]],"region":{"top_left_x":249,"top_left_y":1035,"width":201,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"215ffe44f3734116974d591bbf919c20","type":"text","conversion_output":true,"parent_id":"59d0c3ec45334aea9627b5e82422fbfe","text":"Study Title","text_display":"\n\n\\section*{Study Title}","confidence":1,"confidence_rate":1},{"cnt":[[249,1081],[1815,1081],[1815,1124],[249,1124]],"region":{"top_left_x":249,"top_left_y":1080,"width":1567,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"450a20ae769b41b38c4e63b018870b1c","type":"text","conversion_output":true,"text":"Improving Community Ambulation after Hip Fracture (hereafter referred to as the Community","text_display":"\n\nImproving Community Ambulation after Hip Fracture (hereafter referred to as the Community","confidence":1,"confidence_rate":1},{"cnt":[[245,1126],[746,1126],[746,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1125,"width":502,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e14b698094c34699a93c16975b19b73b","type":"text","conversion_output":true,"text":"Ambulation Project or \"CAP\")","text_display":" Ambulation Project or \"CAP\")","confidence":1,"confidence_rate":1},{"cnt":[[245,1207],[449,1207],[449,1257],[245,1257]],"region":{"top_left_x":244,"top_left_y":1207,"width":206,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b541323cb5144217b89d5394f77d878a","type":"section_header","conversion_output":false,"children_ids":["9c9c224780cc47548ddefe0e4e9c2e49"],"text":"","text_display":""},{"cnt":[[249,1212],[445,1212],[445,1257],[249,1257]],"region":{"top_left_x":249,"top_left_y":1211,"width":196,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c9c224780cc47548ddefe0e4e9c2e49","type":"text","conversion_output":true,"parent_id":"b541323cb5144217b89d5394f77d878a","text":"Objectives","text_display":"\n\n\\section*{Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[249,1257],[1841,1257],[1841,1300],[249,1300]],"region":{"top_left_x":249,"top_left_y":1256,"width":1593,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"421f182946b64f8fbdf6564d341b9123","type":"text","conversion_output":true,"text":"The primary outcome will be ability to walk 300 meters or more in six minutes at the end of the","text_display":"\n\nThe primary outcome will be ability to walk 300 meters or more in six minutes at the end of the","confidence":1,"confidence_rate":1},{"cnt":[[249,1300],[1792,1300],[1792,1343],[249,1343]],"region":{"top_left_x":249,"top_left_y":1299,"width":1543,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2e95675744f4138b83ff76ead37bc9c","type":"text","conversion_output":true,"text":"16-week intervention period. The goal is to enable older adults who have experienced a hip","text_display":" 16-week intervention period. The goal is to enable older adults who have experienced a hip","confidence":0.55419921875,"confidence_rate":0.9938063020308924},{"cnt":[[247,1345],[1815,1345],[1815,1386],[247,1386]],"region":{"top_left_x":247,"top_left_y":1344,"width":1569,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7f53eb355d14c3992b99c89262c6478","type":"text","conversion_output":true,"text":"fracture to recover sufficiently to become community ambulators. In addition, the effect of the","text_display":" fracture to recover sufficiently to become community ambulators. In addition, the effect of the","confidence":1,"confidence_rate":1},{"cnt":[[247,1388],[1807,1388],[1807,1433],[247,1433]],"region":{"top_left_x":247,"top_left_y":1387,"width":1560,"height":47},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80ff69128b0e459c98fbb3785913035b","type":"text","conversion_output":true,"text":"interventions on five precursors for community ambulation will be examined, as will the cost-","text_display":" interventions on five precursors for community ambulation will be examined, as will the cost","confidence":1,"confidence_rate":1},{"cnt":[[249,1431],[1803,1431],[1803,1476],[249,1476]],"region":{"top_left_x":249,"top_left_y":1430,"width":1554,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc5e9949c4d94027ab2294c7ac10c5e7","type":"text","conversion_output":true,"text":"effectiveness of the interventions, and the effect on a set of tertiary outcomes. Precursors to","text_display":"effectiveness of the interventions, and the effect on a set of tertiary outcomes. Precursors to","confidence":1,"confidence_rate":1},{"cnt":[[249,1474],[1760,1474],[1760,1519],[249,1519]],"region":{"top_left_x":249,"top_left_y":1473,"width":1511,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c81fa3acfc9a425291fc80a29e04d3a9","type":"text","conversion_output":true,"text":"community ambulation include measures of endurance, dynamic balance, walking speed,","text_display":" community ambulation include measures of endurance, dynamic balance, walking speed,","confidence":1,"confidence_rate":1},{"cnt":[[247,1521],[1833,1521],[1833,1564],[247,1564]],"region":{"top_left_x":247,"top_left_y":1521,"width":1586,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7707689380de4dd1b8f19a21c00f742d","type":"text","conversion_output":true,"text":"quadriceps strength, and lower extremity function. Tertiary outcomes include activities of daily","text_display":" quadriceps strength, and lower extremity function. Tertiary outcomes include activities of daily","confidence":1,"confidence_rate":1},{"cnt":[[247,1564],[1798,1564],[1798,1609],[247,1609]],"region":{"top_left_x":247,"top_left_y":1564,"width":1552,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bdc07e7bf834232b0428d73c8229d57","type":"text","conversion_output":true,"text":"living (ADLs), quality of life, physical activity, lower extremity physical performance, balance","text_display":" living (ADLs), quality of life, physical activity, lower extremity physical performance, balance","confidence":1,"confidence_rate":1},{"cnt":[[249,1607],[1841,1607],[1841,1652],[249,1652]],"region":{"top_left_x":249,"top_left_y":1607,"width":1593,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"707cdd039cd149718ad0dde25fada916","type":"text","conversion_output":true,"text":"confidence, increase of 50 meters or more in distance walked in six minutes, nutritional status,","text_display":" confidence, increase of 50 meters or more in distance walked in six minutes, nutritional status,","confidence":0.99951171875,"confidence_rate":0.9999953038523913},{"cnt":[[247,1650],[990,1650],[990,1695],[247,1695]],"region":{"top_left_x":247,"top_left_y":1650,"width":744,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"029eaa94b71c411a862240e573a5f20f","type":"text","conversion_output":true,"text":"cognitive status, and depressive symptoms.","text_display":" cognitive status, and depressive symptoms.","confidence":1,"confidence_rate":1},{"cnt":[[245,1736],[660,1736],[660,1785],[245,1785]],"region":{"top_left_x":244,"top_left_y":1735,"width":416,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af5000b57c1d44f38dc39d911b42bfa7","type":"section_header","conversion_output":false,"children_ids":["265b356a34bc4578b31b175a61c5aa7b"],"text":"","text_display":""},{"cnt":[[249,1740],[655,1740],[655,1781],[249,1781]],"region":{"top_left_x":249,"top_left_y":1740,"width":407,"height":42},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"265b356a34bc4578b31b175a61c5aa7b","type":"text","conversion_output":true,"parent_id":"af5000b57c1d44f38dc39d911b42bfa7","text":"Design and Outcomes","text_display":"\n\n\\section*{Design and Outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[245,1783],[1781,1783],[1781,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1783,"width":1538,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4db3c31a2d9a4288b7cd60912c3843db","type":"text","conversion_output":true,"text":"A randomized controlled trial (RCT) including 210 older adults who have experienced a hip","text_display":"\n\nA randomized controlled trial (RCT) including 210 older adults who have experienced a hip","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[1785,1826],[1785,1871],[245,1871]],"region":{"top_left_x":244,"top_left_y":1826,"width":1542,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bffc68efe8f34aee915f18333edd8eff","type":"text","conversion_output":true,"text":"fracture will be carried out at three clinical sites with half of the subjects receiving a specific","text_display":" fracture will be carried out at three clinical sites with half of the subjects receiving a specific","confidence":0.99951171875,"confidence_rate":0.9999953038523913},{"cnt":[[247,1869],[1708,1869],[1708,1914],[247,1914]],"region":{"top_left_x":247,"top_left_y":1869,"width":1462,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fe424e409b14fdaa18153e53d56780d","type":"text","conversion_output":true,"text":"multi-component intervention (PUSH) and the other half receiving a non-specific multi-","text_display":" multi-component intervention (PUSH) and the other half receiving a non-specific multi","confidence":1,"confidence_rate":1},{"cnt":[[247,1916],[1848,1916],[1848,1959],[247,1959]],"region":{"top_left_x":247,"top_left_y":1916,"width":1601,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45aced51a5db4acf94c2346c3e3a84a6","type":"text","conversion_output":true,"text":"component intervention (PULSE). Randomization of 210 participants meeting eligibility criteria","text_display":"component intervention (PULSE). 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The","text_display":"\n\nThe PUSH intervention is based on improving specific precursors to community ambulation. The","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1846,1788],[1846,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1602,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd828951152240ceb8039a88e97590a4","type":"text","conversion_output":true,"text":"intervention addresses endurance with continuous upright exercise for 20 minutes; function by","text_display":" intervention addresses endurance with continuous upright exercise for 20 minutes; function by","confidence":1,"confidence_rate":1},{"cnt":[[245,1833],[1798,1833],[1798,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1832,"width":1555,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"449119b605b648f9b1bf23181d4a7790","type":"text","conversion_output":true,"text":"improving fast walking needed to navigate streets outdoors, standing from a chair, and stair","text_display":" improving fast walking needed to navigate streets outdoors, standing from a chair, and stair","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1697,1878],[1697,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1877,"width":1454,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"697c7bb17f394b34a7f8968627a42296","type":"text","conversion_output":true,"text":"negotiation; muscle performance by exercising to enhance lower extremity strength in","text_display":" negotiation; muscle performance by exercising to enhance lower extremity strength in","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[245,1921],[1837,1921],[1837,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1593,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95e3012f12a4460c9ae0816a1c9b4d80","type":"text","conversion_output":true,"text":"functionally relevant muscles moving through locomotion-appropriate movements and ranges;","text_display":" functionally relevant muscles moving through locomotion-appropriate movements and ranges;","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1811,1964],[1811,2011],[245,2011]],"region":{"top_left_x":244,"top_left_y":1963,"width":1568,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"183a6faea7234703a2801311da3babfd","type":"text","conversion_output":true,"text":"and balance by performing unilateral activities and activities with decreased base of support.","text_display":" and balance by performing unilateral activities and activities with decreased base of support.","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1813,2007],[1813,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1570,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6550074c26434d15aa14d840fa4db92f","type":"text","conversion_output":true,"text":"The components of exercise are woven together into one program that minimizes participant","text_display":" The components of exercise are woven together into one program that minimizes participant","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1760,2054],[1760,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2053,"width":1516,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef744f5b8c4a471bb662d0f2fd815691","type":"text","conversion_output":true,"text":"burden. By the end of the first eight weeks, participants will be instructed to complete the","text_display":" burden. By the end of the first eight weeks, participants will be instructed to complete the","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1815,2097],[1815,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1572,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74996d479bca4f64849b7976ebf461e1","type":"text","conversion_output":true,"text":"endurance component independently one to two times/week by walking for a similar duration","text_display":" endurance component independently one to two times/week by walking for a similar duration","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1577,2140],[1577,2187],[245,2187]],"region":{"top_left_x":244,"top_left_y":2139,"width":1333,"height":49},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e751fc49f82439c96030e6cfaacbf58","type":"text","conversion_output":true,"text":"and intensity as they have been doing with the PT during the supervised visits.","text_display":" and intensity as they have been doing with the PT during the supervised visits.","confidence":1,"confidence_rate":1},{"cnt":[[245,2228],[1794,2228],[1794,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2227,"width":1550,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c72f8f37118a44978d6c4f010c1b6eed","type":"text","conversion_output":true,"text":"The strength components of the muscle performance intervention will be performed using a","text_display":"\n\nThe strength components of the muscle performance intervention will be performed using a","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,2273],[1766,2273],[1766,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1523,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87f299fcce0d4b0f81819f86e512abde","type":"text","conversion_output":true,"text":"portable progressive resistive exercise device (Shuttle® MiniPress, Contemporary Design","text_display":" portable progressive resistive exercise device (Shuttle® MiniPress, Contemporary Design","confidence":0.9990236759185791,"confidence_rate":0.9999893826542317},{"cnt":[[245,2316],[1846,2316],[1846,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":1602,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1428947bf6e54ba6b206aba3f8850c3f","type":"text","conversion_output":true,"text":"Company, P.O. Box 5089, Glacier, WA 98244). Muscle performance will focus on bilateral hip","text_display":" Company, P.O. Box 5089, Glacier, WA 98244). Muscle performance will focus on bilateral hip","confidence":0.9775390625,"confidence_rate":0.9997609019960192},{"cnt":[[245,2359],[1837,2359],[1837,2406],[245,2406]],"region":{"top_left_x":244,"top_left_y":2358,"width":1593,"height":49},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0350d539461b4ab392ce8b54665c4bc5","type":"text","conversion_output":true,"text":"extensors, hip abductors, knee extensors, and plantar flexors because of their role in function,","text_display":" extensors, hip abductors, knee extensors, and plantar flexors because of their role in function,","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1835,2402],[1835,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1591,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f0aad7efba54806853200598caea17f","type":"text","conversion_output":true,"text":"specifically gait and transfer activities. Balance and strength will be addressed with additional","text_display":" specifically gait and transfer activities. Balance and strength will be addressed with additional","confidence":1,"confidence_rate":1},{"cnt":[[245,2449],[1835,2449],[1835,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2449,"width":1591,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5f65a84ffda4a848da1f1a3d560fa24","type":"text","conversion_output":true,"text":"exercises performed while standing. The endurance intervention will begin initially with two to","text_display":" exercises performed while standing. The endurance intervention will begin initially with two to","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cacefdf84f74e128ec2e3356dcacdf0","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1852,2587],[1886,2587],[1886,2628],[1852,2628]],"region":{"top_left_x":1851,"top_left_y":2586,"width":36,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49ae77bca1b74af28c135ddfb4a53d82","type":"page_info","conversion_output":false,"text":"2","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-022","page":22,"lines":[{"cnt":[[245,249],[1852,249],[1852,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1608,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0eab64612c7e4d1db2473a92331a9d4a","type":"text","conversion_output":true,"text":"three minutes of continuous upper and lower extremity active range of motion (AROM) with the","text_display":"\nthree minutes of continuous upper and lower extremity active range of motion (AROM) with the","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1850,296],[1850,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1606,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a44e0b0af684d818dc93f18cd6b6595","type":"text","conversion_output":true,"text":"participant sitting. These exercises are intended to increase the participants' heart rate (HR) or","text_display":" participant sitting. These exercises are intended to increase the participants' heart rate (HR) or","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1826,339],[1826,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1583,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccfd9482c9484daeb779c385420fb038","type":"text","conversion_output":true,"text":"exertion closer to the target zone. The participant will then be asked to walk on level surfaces","text_display":" exertion closer to the target zone. The participant will then be asked to walk on level surfaces","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1785,382],[1785,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1542,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1bad5980a7bf40b18c19f5ee4f13836a","type":"text","conversion_output":true,"text":"and up and down a single or multiple steps, if able and available, to keep the HR within the","text_display":" and up and down a single or multiple steps, if able and available, to keep the HR within the","confidence":0.998046875,"confidence_rate":0.9999798452048033},{"cnt":[[245,425],[1811,425],[1811,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1568,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc096df8311344f197406befd0967870","type":"text","conversion_output":true,"text":"training zone for 20 minutes. The PT may also engage the participant in additional exercises","text_display":" training zone for 20 minutes. The PT may also engage the participant in additional exercises","confidence":0.99072265625,"confidence_rate":0.9999067978802516},{"cnt":[[245,473],[1562,473],[1562,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1318,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed9cace4cfa1444793eb980a9581a62c","type":"text","conversion_output":true,"text":"such as upper and lower extremity AROM exercises to keep the HR elevated.","text_display":" such as upper and lower extremity AROM exercises to keep the HR elevated.","confidence":1,"confidence_rate":1},{"cnt":[[243,554],[595,554],[595,608],[243,608]],"region":{"top_left_x":242,"top_left_y":554,"width":354,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9a8e7aed41e44dc9642e3156c7a7b02","type":"section_header","conversion_output":false,"children_ids":["f95535c4d11a4d1d939038e8ad4ad323"],"text":"","text_display":""},{"cnt":[[245,559],[591,559],[591,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":347,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f95535c4d11a4d1d939038e8ad4ad323","type":"text","conversion_output":true,"parent_id":"c9a8e7aed41e44dc9642e3156c7a7b02","text":"PULSE Intervention","text_display":"\n\n\\section*{PULSE Intervention}","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1837,602],[1837,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1593,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e56e5ec1c0db465ba99fd53d2444137e","type":"text","conversion_output":true,"text":"The PULSE intervention group will receive flexibility exercises, AROM for the upper and lower","text_display":"\n\nThe PULSE intervention group will receive flexibility exercises, AROM for the upper and lower","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1867,645],[1867,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1623,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"208ba4c3f2d44e3ea2a8bdfc39881107","type":"text","conversion_output":true,"text":"extremities, breathing exercises and transcutaneous electrical nerve stimulation (TENS). During","text_display":" extremities, breathing exercises and transcutaneous electrical nerve stimulation (TENS). During","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1824,692],[1824,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1581,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f5e31c34861487b97779281ada86b89","type":"text","conversion_output":true,"text":"the AROM exercises, participants will be working to increase flexibility and range of motion in","text_display":" the AROM exercises, participants will be working to increase flexibility and range of motion in","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1766,735],[1766,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1523,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"166dad9aca034ecbbc5776a190540529","type":"text","conversion_output":true,"text":"order to increase the motion the participant produces. The exercises will include the neck,","text_display":" order to increase the motion the participant produces. The exercises will include the neck,","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1712,778],[1712,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1469,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fb21f5cb517475baf31d634847a4ee3","type":"text","conversion_output":true,"text":"shoulders, arms, trunk, hips, knees and ankles. During all of the AROM exercises, the","text_display":" shoulders, arms, trunk, hips, knees and ankles. During all of the AROM exercises, the","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1815,821],[1815,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1572,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7152a82be82049978d304d433ea9c66c","type":"text","conversion_output":true,"text":"participant will focus on deep breathing techniques. Progression will be gradual by beginning","text_display":" participant will focus on deep breathing techniques. Progression will be gradual by beginning","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1777,868],[1777,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1533,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbf75672dd7347e98c33caff5915b942","type":"text","conversion_output":true,"text":"with three repetitions and slowly progressing to 10 repetitions. We will add a second set of","text_display":" with three repetitions and slowly progressing to 10 repetitions. We will add a second set of","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,911],[1813,911],[1813,958],[245,958]],"region":{"top_left_x":244,"top_left_y":910,"width":1570,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7b60ba431b6467298f583e7098d669a","type":"text","conversion_output":true,"text":"exercises when necessary. This portion of the session will last approximately \\(20-30\\) minutes.","text_display":" exercises when necessary. This portion of the session will last approximately \\(20-30\\) minutes.","confidence":0.9907412528991699,"confidence_rate":0.9999069855689355},{"cnt":[[245,997],[1755,997],[1755,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1512,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52f684f2e5254662aff798fa43d1866d","type":"text","conversion_output":true,"text":"After the AROM exercises, the second part of the session will use sensory level electrical","text_display":"\n\nAfter the AROM exercises, the second part of the session will use sensory level electrical","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1830,1042],[1830,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1587,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37bd4e73b0544b90abc4b86e188c5eb0","type":"text","conversion_output":true,"text":"stimulation on lower extremity muscle groups. The TENS portion of intervention is intended to","text_display":" stimulation on lower extremity muscle groups. The TENS portion of intervention is intended to","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1796,1087],[1796,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1553,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6cb4d3309c9f4a698f5b0e1e567a7f77","type":"text","conversion_output":true,"text":"decrease pain thereby allowing greater ease of mobility. Conventional TENS uses low-level","text_display":" decrease pain thereby allowing greater ease of mobility. Conventional TENS uses low-level","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1871,1130],[1871,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1628,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84c58fb6bed34746ba0dc595534e0f84","type":"text","conversion_output":true,"text":"electrical current to stimulate superficial cutaneous nerve fibers through the skin. The amount of","text_display":" electrical current to stimulate superficial cutaneous nerve fibers through the skin. The amount of","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1790,1173],[1790,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1546,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7f1cf139f9445f99b253bc49c80b496","type":"text","conversion_output":true,"text":"current for sensory level stimulation is that level which the participant detects as a \"tingling\"","text_display":" current for sensory level stimulation is that level which the participant detects as a \"tingling\"","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1717,1216],[1717,1263],[245,1263]],"region":{"top_left_x":244,"top_left_y":1216,"width":1473,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"910c60c8528344ef9f850bb232636f78","type":"text","conversion_output":true,"text":"sensation and is not high enough to produce a visible muscle contraction (below motor","text_display":" sensation and is not high enough to produce a visible muscle contraction (below motor","confidence":1,"confidence_rate":1},{"cnt":[[245,1259],[1852,1259],[1852,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1258,"width":1608,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"587c9b4acb79431097c4138fc4f61a1e","type":"text","conversion_output":true,"text":"threshold). \\({ }^{5}\\) Flexible carbonized, disposable electrodes coated with a self-adhesive conductive","text_display":" threshold). \\({ }^{5}\\) Flexible carbonized, disposable electrodes coated with a self-adhesive conductive","confidence":1,"confidence_rate":1},{"cnt":[[245,1304],[1772,1304],[1772,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1304,"width":1529,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"166ba34840624b4fa1204de9d51835e6","type":"text","conversion_output":true,"text":"polymer will be applied to the skin. The electrodes will be placed bilaterally near the motor","text_display":" polymer will be applied to the skin. The electrodes will be placed bilaterally near the motor","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1869,1349],[1869,1396],[245,1396]],"region":{"top_left_x":244,"top_left_y":1349,"width":1626,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e38e3c08f59489e93b533f254d25250","type":"text","conversion_output":true,"text":"points on muscle bellies (the gluteal complex, the quadriceps, and the gastrocnemius) for seven","text_display":" points on muscle bellies (the gluteal complex, the quadriceps, and the gastrocnemius) for seven","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[1783,1392],[1783,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1540,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a5410015e6b4f62900c133c027284c0","type":"text","conversion_output":true,"text":"minutes per muscle group. The muscle regions selected are important for function after hip","text_display":" minutes per muscle group. The muscle regions selected are important for function after hip","confidence":1,"confidence_rate":1},{"cnt":[[245,1437],[391,1437],[391,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1437,"width":148,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46d586cd6bd5487687e19f2d03956ddc","type":"text","conversion_output":true,"text":"fracture.","text_display":" fracture.","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[241,1521],[612,1521],[612,1575],[241,1575]],"region":{"top_left_x":240,"top_left_y":1521,"width":373,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c9083a8a75a4ac19aebe26d3b79952f","type":"section_header","conversion_output":false,"children_ids":["f879dfb0fe4b4b3fb5fe3f2fe976ec2c"],"text":"","text_display":""},{"cnt":[[245,1525],[608,1525],[608,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":365,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f879dfb0fe4b4b3fb5fe3f2fe976ec2c","type":"text","conversion_output":true,"parent_id":"6c9083a8a75a4ac19aebe26d3b79952f","text":"Nutrition Intervention","text_display":"\n\n\\section*{Nutrition Intervention}","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1682,1568],[1682,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1439,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a213168c9a3d453aa0255a27df92d523","type":"text","conversion_output":true,"text":"Given the importance of maintaining nutrition in both study groups, we will provide all","text_display":"\n\nGiven the importance of maintaining nutrition in both study groups, we will provide all","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1678,1611],[1678,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1434,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9aa5eb8ad5e941eea5cebabb8fc3591a","type":"text","conversion_output":true,"text":"participants (regardless of group) with 2000 IU vitamin D3, 600 mg of calcium, and a","text_display":" participants (regardless of group) with 2000 IU vitamin D3, 600 mg of calcium, and a","confidence":0.9697551727294922,"confidence_rate":0.9996834352863541},{"cnt":[[245,1659],[1824,1659],[1824,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1581,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6139bd09a304f82841b74a9f7375c98","type":"text","conversion_output":true,"text":"multivitamin daily for the 16-week study period. Nutritional counseling will also be provided to","text_display":" multivitamin daily for the 16-week study period. Nutritional counseling will also be provided to","confidence":0.900390625,"confidence_rate":0.9989616623960109},{"cnt":[[245,1702],[1858,1702],[1858,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":1615,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb52623d01a64948a217219332ddd139","type":"text","conversion_output":true,"text":"ensure weight stability, adequate nutrient intake of \\(1.2-1.5 g\\) protein \\(/ kg\\) body weight inclusive of","text_display":" ensure weight stability, adequate nutrient intake of \\(1.2-1.5 g\\) protein \\(/ kg\\) body weight inclusive of","confidence":0.8883988071465865,"confidence_rate":0.9989715333246505},{"cnt":[[245,1745],[1826,1745],[1826,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1744,"width":1583,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"864e0e19a36245e7879b678a24276370","type":"text","conversion_output":true,"text":"a healthy diet ( \\(50 \\%\\) carbohydrate, \\(20 \\%\\) protein, \\(30 \\%\\) fat). Participants will be screened at the","text_display":" a healthy diet ( \\(50 \\%\\) carbohydrate, \\(20 \\%\\) protein, \\(30 \\%\\) fat). Participants will be screened at the","confidence":0.5123564153909683,"confidence_rate":0.9938271422226972},{"cnt":[[245,1788],[1790,1788],[1790,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1546,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5e0362907f7475792b50410f5a26322","type":"text","conversion_output":true,"text":"time of randomization to assess nutritional risk using the Mini Nutritional Assessment-Short","text_display":" time of randomization to assess nutritional risk using the Mini Nutritional Assessment-Short","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[1768,1830],[1768,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1830,"width":1525,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56374622429e40a2ad673673fd66ccb5","type":"text","conversion_output":true,"text":"Form (MNA®-SF). \\({ }^{6}\\) Those who score \\(\\leq 7\\) (malnourished) on the MNA®-SF at baseline and","text_display":" Form (MNA®-SF). \\({ }^{6}\\) Those who score \\(\\leq 7\\) (malnourished) on the MNA®-SF at baseline and","confidence":0.9980480668600649,"confidence_rate":0.999980461784433},{"cnt":[[245,1876],[1850,1876],[1850,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1875,"width":1606,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2dbe8347cca842438f8970bd1a028f88","type":"text","conversion_output":true,"text":"participants with serum albumin \\(2.5-3.5 g / dl\\) (regardless of the score on MNA®-SF) will receive","text_display":" participants with serum albumin \\(2.5-3.5 g / dl\\) (regardless of the score on MNA®-SF) will receive","confidence":0.9951229069851593,"confidence_rate":0.9999543092228845},{"cnt":[[245,1921],[1813,1921],[1813,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1570,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5972150549e14f4ab4f8556fc1a480cf","type":"text","conversion_output":true,"text":"a visit from a registered dietician (RD) from our study in their place of residence within seven","text_display":" a visit from a registered dietician (RD) from our study in their place of residence within seven","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1854,1964],[1854,2011],[245,2011]],"region":{"top_left_x":244,"top_left_y":1963,"width":1611,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8aa64d1807040a5bff498a7e7fe161e","type":"text","conversion_output":true,"text":"days of randomization. The RD will evaluate and counsel them on making dietary modifications","text_display":" days of randomization. The RD will evaluate and counsel them on making dietary modifications","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1794,2007],[1794,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1550,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f11e7641ebf64b6ab8dea4474677b174","type":"text","conversion_output":true,"text":"based on their protein, caloric and other dietary deficiencies using a standardized approach","text_display":" based on their protein, caloric and other dietary deficiencies using a standardized approach","confidence":1,"confidence_rate":1},{"cnt":[[245,2050],[1820,2050],[1820,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2049,"width":1576,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00664c78e3df4af694ecbfb0c90e0d3f","type":"text","conversion_output":true,"text":"across the three study sites. \\({ }^{7-9}\\) The RD will follow up with participants by telephone one week","text_display":" across the three study sites. \\({ }^{7-9}\\) The RD will follow up with participants by telephone one week","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1815,2097],[1815,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1572,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb6623a1644d46a1a720b124a967745b","type":"text","conversion_output":true,"text":"after the visit to assess understanding and implementation of recommendations. Participants","text_display":" after the visit to assess understanding and implementation of recommendations. Participants","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1837,2140],[1837,2187],[245,2187]],"region":{"top_left_x":244,"top_left_y":2139,"width":1593,"height":49},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"392a67354daf40428eff18f74b0e41a9","type":"text","conversion_output":true,"text":"who score \\(8-11\\) (at risk of malnutrition) at baseline and have serum albumin level \\(>3.5 g / dl\\) will","text_display":" who score \\(8-11\\) (at risk of malnutrition) at baseline and have serum albumin level \\(>3.5 g / dl\\) will","confidence":0.9634473075857386,"confidence_rate":0.9996675777540817},{"cnt":[[245,2183],[1869,2183],[1869,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2182,"width":1626,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"961cb1e3b1d44a1cacafa0aba8e0e482","type":"text","conversion_output":true,"text":"receive a telephone dietary consultation with the RD within seven days of randomization. Based","text_display":" receive a telephone dietary consultation with the RD within seven days of randomization. Based","confidence":1,"confidence_rate":1},{"cnt":[[245,2228],[1828,2228],[1828,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2227,"width":1585,"height":49},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4c0a9dfe425487eab955a00974a3ec8","type":"text","conversion_output":true,"text":"on the participant's eating habits and food intake, the RD may make the clinical determination","text_display":" on the participant's eating habits and food intake, the RD may make the clinical determination","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1830,2273],[1830,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1587,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"548e7ea1e7f54ecfa9889525c2762d4e","type":"text","conversion_output":true,"text":"that an in-person consultation is warranted. In these cases, the RD will schedule an in-person","text_display":" that an in-person consultation is warranted. In these cases, the RD will schedule an in-person","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1867,2316],[1867,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":1623,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e80967bc56f42b6ba6406a846566564","type":"text","conversion_output":true,"text":"dietary consultation, following the same protocol as those who score in the malnourished range.","text_display":" dietary consultation, following the same protocol as those who score in the malnourished range.","confidence":1,"confidence_rate":1},{"cnt":[[245,2359],[1751,2359],[1751,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2358,"width":1507,"height":51},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f384a21a5c534bc9a4486789ac852335","type":"text","conversion_output":true,"text":"Those with a score \\(\\geq 12\\) on the MNA®-SF and who have serum albumin level \\(>3.5 g / dl\\) at","text_display":" Those with a score \\(\\geq 12\\) on the MNA®-SF and who have serum albumin level \\(>3.5 g / dl\\) at","confidence":0.9980480668600649,"confidence_rate":0.9999802644306677},{"cnt":[[245,2402],[1854,2402],[1854,2449],[245,2449]],"region":{"top_left_x":244,"top_left_y":2401,"width":1611,"height":49},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11b2248f3e0f4b69b5892a950c41a237","type":"text","conversion_output":true,"text":"baseline will receive brief telephone contact within seven days of randomization from the RD to","text_display":" baseline will receive brief telephone contact within seven days of randomization from the RD to","confidence":1,"confidence_rate":1},{"cnt":[[245,2447],[1846,2447],[1846,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2447,"width":1602,"height":48},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a69249013b64242908ee2f46b51f3e7","type":"text","conversion_output":true,"text":"discuss the importance of calorie and protein intake. Weight will be monitored during home PT","text_display":" discuss the importance of calorie and protein intake. Weight will be monitored during home PT","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2abc183f6cee471e93c67b0e041bdf0b","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1852,2587],[1886,2587],[1886,2628],[1852,2628]],"region":{"top_left_x":1851,"top_left_y":2586,"width":36,"height":42},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b03ca431c93b41bd897abdf518f7a18f","type":"page_info","conversion_output":false,"text":"3","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-023","page":23,"lines":[{"cnt":[[245,249],[1833,249],[1833,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1589,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28114c267853421bb5a86f11988543b2","type":"text","conversion_output":true,"text":"visits every four weeks and those who lose \\(2 \\%\\) or more body weight in a four-week period will","text_display":"\nvisits every four weeks and those who lose \\(2 \\%\\) or more body weight in a four-week period will","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1201,296],[1201,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":957,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f6bb9504f7f4447a6ee634ec4912925","type":"text","conversion_output":true,"text":"receive another telephone consultation by the study RD.","text_display":" receive another telephone consultation by the study RD.","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1824,382],[1824,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1581,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6e59c465ed649238f8d4b8241171adf","type":"text","conversion_output":true,"text":"Participants randomized prior to version 10.0 of the protocol received vitamin D, calcium, and","text_display":"\n\nParticipants randomized prior to version 10.0 of the protocol received vitamin D, calcium, and","confidence":0.9970703125,"confidence_rate":0.9999712358310027},{"cnt":[[245,425],[1848,425],[1848,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1604,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65ceaa538497436aaaccc36884c1f12a","type":"text","conversion_output":true,"text":"multivitamin supplements for a total of 40 weeks. Participants consented under version 10.0 of","text_display":" multivitamin supplements for a total of 40 weeks. Participants consented under version 10.0 of","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1820,473],[1820,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1576,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59bdb1b71b1c4a599be3686088f91dff","type":"text","conversion_output":true,"text":"the protocol will receive vitamin D, calcium, and multivitamin supplements for 16 weeks post-","text_display":" the protocol will receive vitamin D, calcium, and multivitamin supplements for 16 weeks post","confidence":0.9843962125014514,"confidence_rate":0.9998443011521012},{"cnt":[[245,516],[505,516],[505,556],[245,556]],"region":{"top_left_x":244,"top_left_y":515,"width":261,"height":42},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c44afbf3858e4c89b0bc706f3a400bff","type":"text","conversion_output":true,"text":"randomization.","text_display":"randomization.","confidence":1,"confidence_rate":1},{"cnt":[[243,597],[767,597],[767,651],[243,651]],"region":{"top_left_x":242,"top_left_y":597,"width":525,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"061db46a48d74d1da5e8ad4529b9f110","type":"section_header","conversion_output":false,"children_ids":["9f049bec5ebb4bd98999a8769b0aa8a8"],"text":"","text_display":""},{"cnt":[[245,602],[763,602],[763,647],[245,647]],"region":{"top_left_x":244,"top_left_y":601,"width":519,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f049bec5ebb4bd98999a8769b0aa8a8","type":"text","conversion_output":true,"parent_id":"061db46a48d74d1da5e8ad4529b9f110","text":"Sample Size and Population","text_display":"\n\n\\section*{Sample Size and Population}","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1837,645],[1837,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1593,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"542dd7a8486a4af4b2b70175fcf746de","type":"text","conversion_output":true,"text":"The target sample size is 210 randomized hip fracture patients across three clinical sites (with","text_display":"\n\nThe target sample size is 210 randomized hip fracture patients across three clinical sites (with","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1850,692],[1850,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1606,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de71c132c07c4317ba3ea19e4b69f6e5","type":"text","conversion_output":true,"text":"approximately 35 in each treatment group at each site). Study inclusion criteria are: 1) Closed,","text_display":" approximately 35 in each treatment group at each site). 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based on aerobic conditioning, specificity of training, and muscle overload (the PUSH","confidence":1,"confidence_rate":1},{"cnt":[[247,511],[1858,511],[1858,556],[247,556]],"region":{"top_left_x":247,"top_left_y":511,"width":1612,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c42bfc04a723417ea629f56dbf0c23f5","type":"text","conversion_output":true,"text":"intervention), initiated up to 26 weeks following admission to the hospital for hip fracture, will be","text_display":" intervention), initiated up to 26 weeks following admission to the hospital for hip fracture, will be","confidence":1,"confidence_rate":1},{"cnt":[[249,559],[1639,559],[1639,599],[249,599]],"region":{"top_left_x":249,"top_left_y":558,"width":1391,"height":42},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f1f8d2ea3514e53b2c685a7abb63b65","type":"text","conversion_output":true,"text":"more successful in producing community ambulation at 16 weeks after study entry","text_display":" more successful in producing community ambulation at 16 weeks after study entry","confidence":1,"confidence_rate":1},{"cnt":[[249,602],[1699,602],[1699,645],[249,645]],"region":{"top_left_x":249,"top_left_y":601,"width":1451,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00837a680ff141ac9c3e579e7841d4f7","type":"text","conversion_output":true,"text":"(approximately six months post-fracture) compared to a non-specific multi-component","text_display":" (approximately six months post-fracture) compared to a non-specific multi-component","confidence":1,"confidence_rate":1},{"cnt":[[247,645],[1768,645],[1768,690],[247,690]],"region":{"top_left_x":247,"top_left_y":644,"width":1522,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d92c5b0017564864ad23dddc1654a01d","type":"text","conversion_output":true,"text":"intervention of transcutaneous electrical 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the","text_display":"\n\nThe primary hypothesis is that there will be a 20 percentage point or greater difference in the","confidence":1,"confidence_rate":1},{"cnt":[[249,821],[1815,821],[1815,866],[249,866]],"region":{"top_left_x":249,"top_left_y":820,"width":1567,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbc4714cb0c14d65842c2d6c3b872d5b","type":"text","conversion_output":true,"text":"proportion of PUSH compared to PULSE participants who achieve community ambulation 16","text_display":" proportion of PUSH compared to PULSE participants who achieve community ambulation 16","confidence":1,"confidence_rate":1},{"cnt":[[247,864],[1760,864],[1760,909],[247,909]],"region":{"top_left_x":247,"top_left_y":863,"width":1513,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b59ea5895ec645ef8628d8fba41c5892","type":"text","conversion_output":true,"text":"weeks after randomization. Community ambulation will be defined as walking at least 300","text_display":" weeks after randomization. Community ambulation will be defined as walking at least 300","confidence":1,"confidence_rate":1},{"cnt":[[249,907],[1261,907],[1261,952],[249,952]],"region":{"top_left_x":249,"top_left_y":906,"width":1013,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5475844bb5a4413aa1af6dd9e5be3740","type":"text","conversion_output":true,"text":"meters in six minutes on the Six-Minute Walk Test (SMWT).","text_display":" meters in six minutes on the Six-Minute Walk Test (SMWT).","confidence":1,"confidence_rate":1},{"cnt":[[275,993],[814,993],[814,1046],[275,1046]],"region":{"top_left_x":275,"top_left_y":992,"width":540,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6743fb9a15c4d4ab12cc8d8b36ab04f","type":"section_header","conversion_output":false,"children_ids":["183190a71a5a492e88a29ca5388de2c9"],"text":"","text_display":""},{"cnt":[[279,997],[810,997],[810,1042],[279,1042]],"region":{"top_left_x":279,"top_left_y":996,"width":531,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"183190a71a5a492e88a29ca5388de2c9","type":"text","conversion_output":true,"parent_id":"f6743fb9a15c4d4ab12cc8d8b36ab04f","text":"4.2 Secondary Objectives","text_display":"\n\n\\subsection*{4.2 Secondary Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[247,1044],[1708,1044],[1708,1089],[247,1089]],"region":{"top_left_x":247,"top_left_y":1044,"width":1462,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"736a36de2f9949d1bb2a7271a064fa6a","type":"text","conversion_output":true,"text":"Delayed and sustained effects. A secondary objective will be to determine whether the","text_display":"\n\nDelayed and sustained effects. 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To gain a better understanding of the","text_display":" hypothesized to be precursors to community ambulation. To gain a better understanding of the","confidence":1,"confidence_rate":1},{"cnt":[[249,1439],[1876,1439],[1876,1485],[249,1485]],"region":{"top_left_x":249,"top_left_y":1439,"width":1627,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a396602c2ee347f8898944ca16a58654","type":"text","conversion_output":true,"text":"interventions' mechanisms, the two groups will be compared at 16 weeks post-randomization on","text_display":" interventions' mechanisms, the two groups will be compared at 16 weeks post-randomization on","confidence":0.9936552047729492,"confidence_rate":0.999936351935753},{"cnt":[[249,1482],[1852,1482],[1852,1528],[249,1528]],"region":{"top_left_x":249,"top_left_y":1482,"width":1603,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce54e659c7ed4ffeab4eada82e0a1fad","type":"text","conversion_output":true,"text":"each of these outcomes and at 40 weeks post-randomization for the subset of participants who","text_display":" each of these outcomes and at 40 weeks post-randomization for the subset of participants who","confidence":1,"confidence_rate":1},{"cnt":[[247,1525],[1813,1525],[1813,1571],[247,1571]],"region":{"top_left_x":247,"top_left_y":1525,"width":1567,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97794ad702bb42ff9030ecbef4bf8f8b","type":"text","conversion_output":true,"text":"are followed for 40 weeks. 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The economic value of the interventions will be","text_display":"\n\nCost-effectiveness of the interventions. 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This RCT will provide critical information on whether the specific PUSH intervention","text_display":"up period. This RCT will provide critical information on whether the specific PUSH intervention","confidence":1,"confidence_rate":1},{"cnt":[[247,1878],[1772,1878],[1772,1923],[247,1923]],"region":{"top_left_x":247,"top_left_y":1877,"width":1526,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d989c8f11a6143b7bf5d5cccf7940705","type":"text","conversion_output":true,"text":"can improve a hip fracture patient's ability to ambulate in the community in a cost-effective","text_display":" can improve a hip fracture patient's ability to ambulate in the community in a cost-effective","confidence":1,"confidence_rate":1},{"cnt":[[249,1921],[1824,1921],[1824,1966],[249,1966]],"region":{"top_left_x":249,"top_left_y":1920,"width":1576,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92b3059016b54c788f33b94db6bf566f","type":"text","conversion_output":true,"text":"manner compared to the non-specific PULSE intervention. To address the economic value of","text_display":" manner compared to the non-specific PULSE intervention. To address the economic value of","confidence":1,"confidence_rate":1},{"cnt":[[247,1966],[1858,1966],[1858,2013],[247,2013]],"region":{"top_left_x":247,"top_left_y":1965,"width":1612,"height":49},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a01f1723ad0e4f1b9c85c8dfb4abbd82","type":"text","conversion_output":true,"text":"trial interventions versus usual care, a model-based analysis that combines trial data with other","text_display":" trial interventions versus usual care, a model-based analysis that combines trial data with other","confidence":1,"confidence_rate":1},{"cnt":[[247,2011],[879,2011],[879,2050],[247,2050]],"region":{"top_left_x":247,"top_left_y":2010,"width":632,"height":40},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1619b272b1b54711946b936d3fa8aa1b","type":"text","conversion_output":true,"text":"data sources also will be undertaken.","text_display":" data sources also will be undertaken.","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[788,2097],[788,2155],[245,2155]],"region":{"top_left_x":244,"top_left_y":2096,"width":545,"height":59},"line":39,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"861d503b3e0846fa9379c575d95baad1","type":"section_header","conversion_output":false,"children_ids":["34765728de3a4b14b16f5d77a70a8e5c"],"text":"","text_display":""},{"cnt":[[249,2101],[784,2101],[784,2153],[249,2153]],"region":{"top_left_x":249,"top_left_y":2101,"width":536,"height":52},"line":40,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"34765728de3a4b14b16f5d77a70a8e5c","type":"text","conversion_output":true,"parent_id":"861d503b3e0846fa9379c575d95baad1","text":"Section 5: Background","text_display":"\n\n\\section*{Section 5: Background}","confidence":1,"confidence_rate":1},{"cnt":[[249,2174],[1721,2174],[1721,2219],[249,2219]],"region":{"top_left_x":249,"top_left_y":2174,"width":1472,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4dad233cb7d451cb5de2fed6b44ff48","type":"text","conversion_output":true,"text":"Current standard Medicare-reimbursed rehabilitation therapy fails to restore community","text_display":"\n\nCurrent standard Medicare-reimbursed rehabilitation therapy fails to restore community","confidence":1,"confidence_rate":1},{"cnt":[[247,2219],[1858,2219],[1858,2262],[247,2262]],"region":{"top_left_x":247,"top_left_y":2219,"width":1612,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9730cf69c3bf402abeda93ca8985491c","type":"text","conversion_output":true,"text":"ambulation to older persons who have had a hip fracture. A residual mobility disability similar to","text_display":" ambulation to older persons who have had a hip fracture. A residual mobility disability similar to","confidence":1,"confidence_rate":1},{"cnt":[[247,2260],[1858,2260],[1858,2305],[247,2305]],"region":{"top_left_x":247,"top_left_y":2260,"width":1612,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"645a5f80bc37456082d4ee9cb1d16c94","type":"text","conversion_output":true,"text":"that reported for stroke occurs in the majority of persons who \"recover\" from hip fracture. \\({ }^{10,11}\\) In","text_display":" that reported for stroke occurs in the majority of persons who \"recover\" from hip fracture. \\({ }^{10,11}\\) In","confidence":0.8217344284057617,"confidence_rate":0.9982941694905507},{"cnt":[[247,2307],[1747,2307],[1747,2348],[247,2348]],"region":{"top_left_x":247,"top_left_y":2307,"width":1500,"height":42},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93238018534d4731ab4735ba6ecbfab5","type":"text","conversion_output":true,"text":"contrast to stroke, heart disease, and cancer, there are few intervention trials focused on","text_display":" contrast to stroke, heart disease, and cancer, there are few intervention trials focused on","confidence":1,"confidence_rate":1},{"cnt":[[249,2350],[1833,2350],[1833,2396],[249,2396]],"region":{"top_left_x":249,"top_left_y":2350,"width":1584,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e2a9c8f029e42778f76edeaea9c6dbf","type":"text","conversion_output":true,"text":"decreasing disability following hip fracture. The paucity of intervention trials is surprising since","text_display":" decreasing disability following hip fracture. The paucity of intervention trials is surprising since","confidence":1,"confidence_rate":1},{"cnt":[[247,2393],[1790,2393],[1790,2438],[247,2438]],"region":{"top_left_x":247,"top_left_y":2393,"width":1543,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"baa96790981c47e8935881ad7b261f2b","type":"text","conversion_output":true,"text":"there are over 325,000 hip fractures per year in the U.S. \\({ }^{12}\\) with a predicted increase to over","text_display":" there are over 325,000 hip fractures per year in the U.S. \\({ }^{12}\\) with a predicted increase to over","confidence":0.8854568004608154,"confidence_rate":0.9989144145994033},{"cnt":[[247,2436],[1824,2436],[1824,2481],[247,2481]],"region":{"top_left_x":247,"top_left_y":2436,"width":1578,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48a207ff63a44ba9be476816529fcb33","type":"text","conversion_output":true,"text":"650,000 per year by \\(2040 .{ }^{13}\\) The estimated cost to hip fracture patients, their families and the","text_display":" 650,000 per year by \\(2040 .{ }^{13}\\) The estimated cost to hip fracture patients, their families and the","confidence":0.5384352539726933,"confidence_rate":0.9943877349902942},{"cnt":[[249,2587],[660,2587],[660,2623],[249,2623]],"region":{"top_left_x":249,"top_left_y":2586,"width":411,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f77076b26cfa4bed98ce6fcf4c8fda3d","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c198acd7d9549fb9ca0c0754b887eca","type":"page_info","conversion_output":false,"text":"12","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-032","page":32,"lines":[{"cnt":[[245,247],[1772,247],[1772,299],[245,299]],"region":{"top_left_x":244,"top_left_y":247,"width":1529,"height":52},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9488d0a60dcc464b9748b968f41c6141","type":"text","conversion_output":true,"text":"health care system is between \\(\\$ 14\\) and \\(\\$ 20\\) billion annually. \\({ }^{14-19}\\) A Cochrane Collaboration","text_display":"\nhealth care system is between \\(\\$ 14\\) and \\(\\$ 20\\) billion annually. \\({ }^{14-19}\\) A Cochrane Collaboration","confidence":0.9941470623016357,"confidence_rate":0.9999471173148481},{"cnt":[[245,296],[1760,296],[1760,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1516,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e1e182c5b5a49d38493905dfb81a836","type":"text","conversion_output":true,"text":"review on interventions post-hip fracture concluded that there is not sufficient evidence to","text_display":" review on interventions post-hip fracture concluded that there is not sufficient evidence to","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1803,339],[1803,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1559,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"054d8a625a2b494396dd368bf4342e58","type":"text","conversion_output":true,"text":"determine if the interventions evaluated substantially reduce residual disability and enhance","text_display":" determine if the interventions evaluated substantially reduce residual disability and enhance","confidence":1,"confidence_rate":1},{"cnt":[[245,380],[677,380],[677,432],[245,432]],"region":{"top_left_x":244,"top_left_y":380,"width":433,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0b88b279a2d49d78cc296b093580cb8","type":"text","conversion_output":true,"text":"community ambulation. \\({ }^{20}\\)","text_display":" community ambulation. \\({ }^{20}\\)","confidence":1,"confidence_rate":1},{"cnt":[[269,466],[1545,466],[1545,526],[269,526]],"region":{"top_left_x":268,"top_left_y":466,"width":1277,"height":61},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"587824c2c5864ad48e953da2ff410859","type":"section_header","conversion_output":false,"children_ids":["4c327782128045ac80faef95bf218258"],"text":"","text_display":""},{"cnt":[[275,471],[1538,471],[1538,522],[275,522]],"region":{"top_left_x":275,"top_left_y":470,"width":1264,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c327782128045ac80faef95bf218258","type":"text","conversion_output":true,"parent_id":"587824c2c5864ad48e953da2ff410859","text":"5.1 Residual Deficits in Precursors of Community Ambulation","text_display":"\n\n\\subsection*{5.1 Residual Deficits in Precursors of Community Ambulation}","confidence":0.99951171875,"confidence_rate":0.999992368771335},{"cnt":[[245,520],[1794,520],[1794,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":1550,"height":47},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b212a4ea2a5e4af28a4f46aeef109293","type":"text","conversion_output":true,"text":"Effective community ambulation requires sufficiency in five physical precursors: endurance;","text_display":"\n\nEffective community ambulation requires sufficiency in five physical precursors: endurance;","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,563],[1863,563],[1863,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1619,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"323cf7b5670b440ca73598a8d71b58f0","type":"text","conversion_output":true,"text":"dynamic balance; lower limb muscle strength; walking speed; and lower extremity function. The","text_display":" dynamic balance; lower limb muscle strength; walking speed; and lower extremity function. The","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1781,606],[1781,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1538,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c1918ed4a3c4ee5babfb70257dff018","type":"text","conversion_output":true,"text":"precursors enable the person to get up out of bed, get out the front door, and participate in","text_display":" precursors enable the person to get up out of bed, get out the front door, and participate in","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1863,649],[1863,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":1619,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c1826709ac94921b37e756a147132af","type":"text","conversion_output":true,"text":"community activities. Previous studies indicate significant residual impairments for persons with","text_display":" community activities. Previous studies indicate significant residual impairments for persons with","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1029,692],[1029,741],[245,741]],"region":{"top_left_x":244,"top_left_y":691,"width":786,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8739d9784a014b33a5d79d40befd51d4","type":"text","conversion_output":true,"text":"hip fracture who have completed \"usual\" care.","text_display":" hip fracture who have completed \"usual\" care.","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1729,782],[1729,827],[245,827]],"region":{"top_left_x":244,"top_left_y":782,"width":1486,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d019cc9d55d14d96a0e83b4f27c7d98f","type":"text","conversion_output":true,"text":"Endurance. Deconditioning is expected following a hip fracture, but there is a paucity of","text_display":"\n\nEndurance. Deconditioning is expected following a hip fracture, but there is a paucity of","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1861,821],[1861,872],[245,872]],"region":{"top_left_x":244,"top_left_y":820,"width":1617,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa4bd35267824ee5ad1e8acd6619a2ea","type":"text","conversion_output":true,"text":"evidence on aerobic capacity from maximal treadmill or cycle ergometry exercise tests. \\({ }^{21-25}\\) The","text_display":" evidence on aerobic capacity from maximal treadmill or cycle ergometry exercise tests. \\({ }^{21-25}\\) The","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1848,868],[1848,917],[245,917]],"region":{"top_left_x":244,"top_left_y":867,"width":1604,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c328658accd4d158ffeefe862ea4f56","type":"text","conversion_output":true,"text":"only study that examined peak oxygen uptake ( \\(VO _{2}\\) peak) values in 20 persons within a month","text_display":" only study that examined peak oxygen uptake ( \\(VO _{2}\\) peak) values in 20 persons within a month","confidence":0.9975595474243164,"confidence_rate":0.9999781838510657},{"cnt":[[245,915],[1749,915],[1749,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1505,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f959e25d4dc54ddaad6c298fa17d3fa3","type":"text","conversion_output":true,"text":"of fracture, reported significantly lower peak values in hip fracture vs healthy community-","text_display":" of fracture, reported significantly lower peak values in hip fracture vs healthy community","confidence":1,"confidence_rate":1},{"cnt":[[245,956],[1745,956],[1745,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":956,"width":1501,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0942d3503fd46e59e4432d6c72fda9a","type":"text","conversion_output":true,"text":"dwelling older adults. \\({ }^{26}\\) The SMWT has been used as a proxy for aerobic capacity and is","text_display":"dwelling older adults. \\({ }^{26}\\) The SMWT has been used as a proxy for aerobic capacity and is","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1742,1001],[1742,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1499,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84823f122fe24f018a28b01e54001d53","type":"text","conversion_output":true,"text":"considered an endurance measure in elderly, frail and severely compromised patients. \\({ }^{27}\\)","text_display":" considered an endurance measure in elderly, frail and severely compromised patients. \\({ }^{27}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1854,1044],[1854,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":1611,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50d4d970b41c4813a9942ccb76bca5d8","type":"text","conversion_output":true,"text":"Performance on the SMWT by persons post-hip fracture closely resembles that of patients with","text_display":" Performance on the SMWT by persons post-hip fracture closely resembles that of patients with","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1785,1087],[1785,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1542,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d7c5418c640441694d76e4a4b40a749","type":"text","conversion_output":true,"text":"New York Heart Association class III or IV heart failure who walk 217 meters on average. \\({ }^{28}\\)","text_display":" New York Heart Association class III or IV heart failure who walk 217 meters on average. \\({ }^{28}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1846,1130],[1846,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1130,"width":1602,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8eb4b4b7e6bc4390939653ff6356302d","type":"text","conversion_output":true,"text":"Mangione reported average SMWT distances of approximately 200 meters after usual care for","text_display":" Mangione reported average SMWT distances of approximately 200 meters after usual care for","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,1177],[1826,1177],[1826,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1177,"width":1583,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"577939f909034df69c171279e637c281","type":"text","conversion_output":true,"text":"hip fracture. \\({ }^{29}\\) Work in Baltimore and in the pilot study for this trial indicate an average SMWT","text_display":" hip fracture. \\({ }^{29}\\) Work in Baltimore and in the pilot study for this trial indicate an average SMWT","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1818,1220],[1818,1268],[245,1268]],"region":{"top_left_x":244,"top_left_y":1220,"width":1574,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa95b2976bdc4d8b9ce865576b701bd0","type":"text","conversion_output":true,"text":"distance of 154 m and 184 m , respectively, at six months post-fracture. This contrasts to 400","text_display":" distance of 154 m and 184 m , respectively, at six months post-fracture. This contrasts to 400","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1846,1263],[1846,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1263,"width":1602,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"439b9637202f4481ad0f430c58466ff4","type":"text","conversion_output":true,"text":"meters reported for 80 -year-olds living in the community \\({ }^{30}\\) or 350 meters reported for a sample","text_display":" meters reported for 80 -year-olds living in the community \\({ }^{30}\\) or 350 meters reported for a sample","confidence":0.9970715045928955,"confidence_rate":0.9999749337172424},{"cnt":[[245,1306],[1205,1306],[1205,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1306,"width":962,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2abe2325ca245b2b2f0f0622d11f265","type":"text","conversion_output":true,"text":"of comparable age in the Cardiovascular Health Study. \\({ }^{31}\\)","text_display":" of comparable age in the Cardiovascular Health Study. \\({ }^{31}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1841,1396],[1841,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1598,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfae56f59ad3499f9fa7f0d3ba2184b1","type":"text","conversion_output":true,"text":"Balance. Dynamic balance is compromised after hip fracture. For example, at the end of usual","text_display":"\n\nBalance. Dynamic balance is compromised after hip fracture. For example, at the end of usual","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1841,1439],[1841,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1598,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c8966c088484acebd2c4d8e95295852","type":"text","conversion_output":true,"text":"care ( \\(2-3\\) months post-fracture), \\(20 \\%\\) who had regained independence in ADL reported falling;","text_display":" care ( \\(2-3\\) months post-fracture), \\(20 \\%\\) who had regained independence in ADL reported falling;","confidence":0.6216312116011977,"confidence_rate":0.9953950213112422},{"cnt":[[245,1487],[1846,1487],[1846,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1602,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"627752c0e0e8481ba2747aca799132e9","type":"text","conversion_output":true,"text":"those who had fallen since hospital discharge had poorer balance compared to those who had","text_display":" those who had fallen since hospital discharge had poorer balance compared to those who had","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1858,1525],[1858,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1525,"width":1615,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf380a745d30460197edf83fbf39f513","type":"text","conversion_output":true,"text":"not fallen. \\({ }^{10,32}\\) Fifty-three percent of patients who were community dwelling pre-fracture fell one","text_display":" not fallen. \\({ }^{10,32}\\) Fifty-three percent of patients who were community dwelling pre-fracture fell one","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1835,1573],[1835,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1572,"width":1591,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4c9964906fc49c894fa86c97dbf1bb7","type":"text","conversion_output":true,"text":"or more times in the first six months post-fracture and \\(18 \\%\\) were readmitted to the hospital for","text_display":" or more times in the first six months post-fracture and \\(18 \\%\\) were readmitted to the hospital for","confidence":0.8291015625,"confidence_rate":0.9981821143662617},{"cnt":[[245,1616],[1871,1616],[1871,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1615,"width":1628,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01d030e5ba2946b3b0937ec3f6c3cee9","type":"text","conversion_output":true,"text":"fall-related injury. \\({ }^{10}\\) Balance deficits remain at seven months \\({ }^{33}\\) at a time when physical recovery","text_display":" fall-related injury. \\({ }^{10}\\) Balance deficits remain at seven months \\({ }^{33}\\) at a time when physical recovery","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[862,1659],[862,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1658,"width":618,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5add61b8e21e42f1bad19803ee949d00","type":"text","conversion_output":true,"text":"is reported to approach a plateau. \\({ }^{1,2}\\)","text_display":" is reported to approach a plateau. \\({ }^{1,2}\\)","confidence":0.9809749083360657,"confidence_rate":0.9996080687152836},{"cnt":[[245,1749],[1846,1749],[1846,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1602,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9611e0c4bed249ed9d1e689dc6bc3bb7","type":"text","conversion_output":true,"text":"Walking Speed. The proportion of individuals achieving independence in ambulation one year","text_display":"\n\nWalking Speed. The proportion of individuals achieving independence in ambulation one year","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1792],[1858,1792],[1858,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1615,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"183b160761e849c0987b2326d560273a","type":"text","conversion_output":true,"text":"post-fracture is between \\(30 \\%\\) and \\(83 \\%\\), depending on the study. \\({ }^{34-37}\\) Reasons for the variation","text_display":" post-fracture is between \\(30 \\%\\) and \\(83 \\%\\), depending on the study. \\({ }^{34-37}\\) Reasons for the variation","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1858,1835],[1858,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1615,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"604fb843cf7f4c27b8b1bcbe99e25d0b","type":"text","conversion_output":true,"text":"in reported ambulatory status include the use of different measures, differences in the length of","text_display":" in reported ambulatory status include the use of different measures, differences in the length of","confidence":1,"confidence_rate":1},{"cnt":[[245,1880],[1824,1880],[1824,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1879,"width":1581,"height":49},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"110f5aa9b0cd41bab220e2e188f126b9","type":"text","conversion_output":true,"text":"follow-up time and different definitions of recovery. It has also been observed that recovery in","text_display":" follow-up time and different definitions of recovery. It has also been observed that recovery in","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1721,1921],[1721,1972],[245,1972]],"region":{"top_left_x":244,"top_left_y":1920,"width":1477,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b1c508c1ee24feda2e61c21d5c12f61","type":"text","conversion_output":true,"text":"gait speed does not reach a plateau until almost a year post-fracture (Magaziner 2000)","text_display":" gait speed does not reach a plateau until almost a year post-fracture (Magaziner 2000)","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1751,1968],[1751,2015],[245,2015]],"region":{"top_left_x":244,"top_left_y":1967,"width":1507,"height":49},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e86dcdc5e5ca4de7a696e251d975a97a","type":"text","conversion_output":true,"text":"suggesting that interventions prior to that time might add to the natural recovery process.","text_display":" suggesting that interventions prior to that time might add to the natural recovery process.","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1811,2054],[1811,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2053,"width":1568,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b7d4272f56d4fde9dd32e0d4801903d","type":"text","conversion_output":true,"text":"Lower Extremity Muscle Strength. Hip fracture is accompanied by rapid loss of muscle mass","text_display":"\n\nLower Extremity Muscle Strength. Hip fracture is accompanied by rapid loss of muscle mass","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1871,2097],[1871,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2096,"width":1628,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5340ff8c08db45cf9e47b24337f3c2d9","type":"text","conversion_output":true,"text":"and weakness. \\({ }^{38}\\) Muscle weakness is not the sole impairment accounting for extensive residual","text_display":" and weakness. \\({ }^{38}\\) Muscle weakness is not the sole impairment accounting for extensive residual","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1824,2144],[1824,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1581,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebe5e6fa3adf4e159ce3fc13685fb05d","type":"text","conversion_output":true,"text":"disability post-fracture, but its contribution is significant. Leg, thigh, and hip muscle weakness","text_display":" disability post-fracture, but its contribution is significant. Leg, thigh, and hip muscle weakness","confidence":1,"confidence_rate":1},{"cnt":[[245,2187],[1794,2187],[1794,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2187,"width":1550,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7db284a862649d5831f445f95e20ba5","type":"text","conversion_output":true,"text":"are related to decreased muscle power and walking speed. \\({ }^{39-42}\\) Muscle weakness appears,","text_display":" are related to decreased muscle power and walking speed. \\({ }^{39-42}\\) Muscle weakness appears,","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1283,2230],[1283,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1039,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fad5fcb0d1f49d99553691cfbeae887","type":"text","conversion_output":true,"text":"therefore, to be a major factor in producing mobility disability.","text_display":" therefore, to be a major factor in producing mobility disability.","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1841,2320],[1841,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2320,"width":1598,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a2125aa4f8342d18a0c24591f5b222a","type":"text","conversion_output":true,"text":"Lower Extremity Function. A hip fracture results in limited lower extremity function that, in turn,","text_display":"\n\nLower Extremity Function. A hip fracture results in limited lower extremity function that, in turn,","confidence":1,"confidence_rate":1},{"cnt":[[245,2361],[1837,2361],[1837,2411],[245,2411]],"region":{"top_left_x":244,"top_left_y":2361,"width":1593,"height":50},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e8ea456e6c74cc5a86d0176bc0e017d","type":"text","conversion_output":true,"text":"compromises physical, instrumental and social function. \\({ }^{43,44}\\) At six months post-fracture when","text_display":" compromises physical, instrumental and social function. \\({ }^{43,44}\\) At six months post-fracture when","confidence":1,"confidence_rate":1},{"cnt":[[245,2406],[1768,2406],[1768,2456],[245,2456]],"region":{"top_left_x":244,"top_left_y":2406,"width":1525,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4299e40a009b47c39a521f6e01577137","type":"text","conversion_output":true,"text":"physical recovery is reported to plateau, a limited proportion of hip fracture patients report","text_display":" physical recovery is reported to plateau, a limited proportion of hip fracture patients report","confidence":1,"confidence_rate":1},{"cnt":[[245,2449],[1843,2449],[1843,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2449,"width":1600,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f08f3c9b6b8847cfa0d781bc62b9d17a","type":"text","conversion_output":true,"text":"climbing a flight of stairs \\((8 \\%)\\) or walking one half a mile \\((6 \\%) .^{2,45}\\) The majority of patients who","text_display":" climbing a flight of stairs \\((8 \\%)\\) or walking one half a mile \\((6 \\%) .^{2,45}\\) The majority of patients who","confidence":0.4540327550746536,"confidence_rate":0.9932163383136035},{"cnt":[[245,2585],[660,2585],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2584,"width":416,"height":40},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81ebc05ce69e4a529b075eab6dab1487","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d24d3a010864e858118df0c489d0cfd","type":"page_info","conversion_output":false,"text":"13","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-033","page":33,"lines":[{"cnt":[[245,247],[1852,247],[1852,299],[245,299]],"region":{"top_left_x":244,"top_left_y":247,"width":1608,"height":52},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcb7aad05077475dafb557a817cc0f8e","type":"text","conversion_output":true,"text":"report independent ambulation also report they do not walk as well they did prior to fracture. \\({ }^{1,46}\\)","text_display":"\nreport independent ambulation also report they do not walk as well they did prior to fracture. \\({ }^{1,46}\\)","confidence":0.9975595474243164,"confidence_rate":0.9999777871982178},{"cnt":[[245,292],[1858,292],[1858,342],[245,342]],"region":{"top_left_x":244,"top_left_y":292,"width":1615,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ad799a2fdfb42bdac1e9f1b92f42fb5","type":"text","conversion_output":true,"text":"Even at one year, most hip fracture patients do not return to pre-fracture functional status. \\({ }^{2,45,47-}\\)","text_display":" Even at one year, most hip fracture patients do not return to pre-fracture functional status. \\({ }^{2,45,47-}","confidence":0.6484780311584473,"confidence_rate":0.9961743528575301},{"cnt":[[245,335],[1472,335],[1472,387],[245,387]],"region":{"top_left_x":244,"top_left_y":335,"width":1228,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b9ab1d03ae347379ca83b1639808d27","type":"text","conversion_output":true,"text":"\\({ }^{50}\\) They walk more unsteadily and more slowly for shorter distances. \\({ }^{51,52}\\)","text_display":" { }^{50}\\) They walk more unsteadily and more slowly for shorter distances. \\({ }^{51,52}\\)","confidence":0.9423828125,"confidence_rate":0.9993408428478052},{"cnt":[[245,425],[1783,425],[1783,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1540,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7302c4bcb0140aeab4de445e9d32a91","type":"text","conversion_output":true,"text":"Summary: The numbers and costs of hip fracture are significant, and one to two months of","text_display":"\n\nSummary: The numbers and costs of hip fracture are significant, and one to two months of","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1833,473],[1833,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1589,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a91f7ffdddf2411bbdd5a55344cf5e3c","type":"text","conversion_output":true,"text":"usual care is inadequate for restoring function to this patient group. Most hip fracture patients","text_display":" usual care is inadequate for restoring function to this patient group. Most hip fracture patients","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1828,516],[1828,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1585,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eed340851d6049918d94500d30e5cc9f","type":"text","conversion_output":true,"text":"do not regain pre-fracture mobility status. Endurance, dynamic balance, walking speed, lower","text_display":" do not regain pre-fracture mobility status. Endurance, dynamic balance, walking speed, lower","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1790,559],[1790,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1546,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"229e0e49f103444ca8973216cffae2ef","type":"text","conversion_output":true,"text":"extremity muscle strength, and lower extremity function are compromised and contribute to","text_display":" extremity muscle strength, and lower extremity function are compromised and contribute to","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[943,602],[943,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":700,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f51ccdff83149e29f878c11c9b0b311","type":"text","conversion_output":true,"text":"failure to achieve community ambulation.","text_display":" failure to achieve community ambulation.","confidence":1,"confidence_rate":1},{"cnt":[[271,687],[1300,687],[1300,741],[271,741]],"region":{"top_left_x":270,"top_left_y":687,"width":1030,"height":55},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9682f6254ae45ba9fcec84ab52d10dc","type":"section_header","conversion_output":true,"text":"5.2 Exercise Studies in Persons after Hip Fracture","text_display":"\n\n\\subsection*{5.2 Exercise Studies in Persons after Hip Fracture}","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1863,735],[1863,784],[245,784]],"region":{"top_left_x":244,"top_left_y":734,"width":1619,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1bcf62e24e6648e5b7ef060792852719","type":"text","conversion_output":true,"text":"Based on the results of Mangione's survey of 1000 home care PTs, \\({ }^{53}\\) we propose that a reason","text_display":"\n\nBased on the results of Mangione's survey of 1000 home care PTs, \\({ }^{53}\\) we propose that a reason","confidence":0.9970715045928955,"confidence_rate":0.9999733386114221},{"cnt":[[245,782],[1852,782],[1852,829],[245,829]],"region":{"top_left_x":244,"top_left_y":782,"width":1608,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcd4fbac0a2b489bb81e90e512042e9b","type":"text","conversion_output":true,"text":"for the residual disability after hip fracture is an inadequate dose of physical intervention during","text_display":" for the residual disability after hip fracture is an inadequate dose of physical intervention during","confidence":1,"confidence_rate":1},{"cnt":[[245,827],[1755,827],[1755,872],[245,872]],"region":{"top_left_x":244,"top_left_y":827,"width":1512,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd6d1cf468624a5aa0717e46f79e89fb","type":"text","conversion_output":true,"text":"usual care. A limited number of investigations have examined the direct effect of physical","text_display":" usual care. A limited number of investigations have examined the direct effect of physical","confidence":1,"confidence_rate":1},{"cnt":[[245,870],[1704,870],[1704,917],[245,917]],"region":{"top_left_x":244,"top_left_y":870,"width":1460,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"029cf0eacf85461bb68d20fc43ab2c8c","type":"text","conversion_output":true,"text":"interventions on increasing community ambulation. Only 15 studies were included in a","text_display":" interventions on increasing community ambulation. Only 15 studies were included in a","confidence":1,"confidence_rate":1},{"cnt":[[245,913],[1830,913],[1830,960],[245,960]],"region":{"top_left_x":244,"top_left_y":913,"width":1587,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1abe0b504bb4b75ac460f0018205c96","type":"text","conversion_output":true,"text":"systematic review of physical therapy management of hip fracture. \\({ }^{54} A\\) finding relevant to this","text_display":" systematic review of physical therapy management of hip fracture. \\({ }^{54} A\\) finding relevant to this","confidence":0.986328125,"confidence_rate":0.9998770950912473},{"cnt":[[245,958],[1846,958],[1846,1005],[245,1005]],"region":{"top_left_x":244,"top_left_y":958,"width":1602,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26185abb9da84d60a5c1b9e9896c2f09","type":"text","conversion_output":true,"text":"study is that usual care outcomes were similar for home, acute rehabilitation, or skilled nursing","text_display":" study is that usual care outcomes were similar for home, acute rehabilitation, or skilled nursing","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[397,1001],[397,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":1001,"width":154,"height":41},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e531943a85a42898d7f20615e2d12f9","type":"text","conversion_output":true,"text":"facilities.","text_display":" facilities.","confidence":1,"confidence_rate":1},{"cnt":[[243,1087],[1854,1087],[1854,1137],[243,1137]],"region":{"top_left_x":242,"top_left_y":1087,"width":1613,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"015186346b924fa0a46c20a43ae2cc7e","type":"text","conversion_output":true,"text":"A Cochrane Collaboration review of exercise interventions \\({ }^{20}\\) identified 13 clinical trials in 1,065","text_display":"\n\nA Cochrane Collaboration review of exercise interventions \\({ }^{20}\\) identified 13 clinical trials in 1,065","confidence":0.8116152286529541,"confidence_rate":0.9982175826398293},{"cnt":[[245,1134],[1858,1134],[1858,1182],[245,1182]],"region":{"top_left_x":244,"top_left_y":1134,"width":1615,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"196eb4eb9f4643e189d51994c03f65b8","type":"text","conversion_output":true,"text":"patients and concluded that there was insufficient evidence to determine if physical intervention","text_display":" patients and concluded that there was insufficient evidence to determine if physical intervention","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1622,1177],[1622,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1177,"width":1379,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15a1d664acb04359a9abd07d3bde4662","type":"text","conversion_output":true,"text":"affected outcome post-hip fracture. Seven trials \\({ }^{26,55-60}\\) provided intervention early","text_display":" affected outcome post-hip fracture. Seven trials \\({ }^{26,55-60}\\) provided intervention early","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1833,1220],[1833,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1220,"width":1589,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb3fb36227994cc0a5b85545fdd4f9a1","type":"text","conversion_output":true,"text":"(approximately two months) after hip fracture. Various combinations of low intensity AROM or","text_display":" (approximately two months) after hip fracture. Various combinations of low intensity AROM or","confidence":1,"confidence_rate":1},{"cnt":[[245,1265],[1800,1265],[1800,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1265,"width":1557,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5419f6c198d45b3ae9f7462bf395512","type":"text","conversion_output":true,"text":"flexibility exercises, functional training, strengthening, and balance exercise did not produce","text_display":" flexibility exercises, functional training, strengthening, and balance exercise did not produce","confidence":1,"confidence_rate":1},{"cnt":[[245,1308],[1858,1308],[1858,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1308,"width":1615,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db4492fd915a4d5c9d7aad548d83bf49","type":"text","conversion_output":true,"text":"outcomes that were different from \"usual care\" with three exceptions. \\({ }^{26,55,56}\\) Since the Cochrane","text_display":" outcomes that were different from \"usual care\" with three exceptions. \\({ }^{26,55,56}\\) Since the Cochrane","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[245,1354],[1777,1354],[1777,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1533,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef075e1769b34de2ba00b19a0f409ae1","type":"text","conversion_output":true,"text":"review, two additional trials intervened with exercise programs early after hip fracture. One","text_display":" review, two additional trials intervened with exercise programs early after hip fracture. One","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1837,1396],[1837,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1593,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f509fe554ca40ccad9664b859b46da0","type":"text","conversion_output":true,"text":"offered a one-month intervention focused on falls efficacy and reported initial improvements in","text_display":" offered a one-month intervention focused on falls efficacy and reported initial improvements in","confidence":0.9985356330871582,"confidence_rate":0.9999853457059158},{"cnt":[[245,1439],[1818,1439],[1818,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1574,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"704457c02c4b44a0b3c63f1d4c1b4a5e","type":"text","conversion_output":true,"text":"walking outdoors and ADLs at two months post-fracture. \\({ }^{61}\\) Another trial reported no benefit in","text_display":" walking outdoors and ADLs at two months post-fracture. \\({ }^{61}\\) Another trial reported no benefit in","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[245,1487],[1850,1487],[1850,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1606,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05a9b9f5a15e44a4bc81265e20326990","type":"text","conversion_output":true,"text":"knee extensor muscle strength or walking speed compared to the control group following a 16 -","text_display":" knee extensor muscle strength or walking speed compared to the control group following a 16 ","confidence":0.79541015625,"confidence_rate":0.9977362554742141},{"cnt":[[245,1525],[1807,1525],[1807,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1525,"width":1563,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eebb8816298945c1be2102f6d2abf39a","type":"text","conversion_output":true,"text":"week, home-based strengthening program. \\({ }^{62}\\) We believe that differences were not observed","text_display":"week, home-based strengthening program. \\({ }^{62}\\) We believe that differences were not observed","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1833,1573],[1833,1620],[245,1620]],"region":{"top_left_x":244,"top_left_y":1572,"width":1589,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"072812051cae4b299567606ee7c27a31","type":"text","conversion_output":true,"text":"because the exercise dose was inadequate. This hypothesis is supported by three small trials","text_display":" because the exercise dose was inadequate. This hypothesis is supported by three small trials","confidence":1,"confidence_rate":1},{"cnt":[[245,1618],[1833,1618],[1833,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1617,"width":1589,"height":49},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e30a1d79f329403c9bac2d9a52ad02ed","type":"text","conversion_output":true,"text":"which reported between-group differences and demonstrate that higher intensity exercise can","text_display":" which reported between-group differences and demonstrate that higher intensity exercise can","confidence":1,"confidence_rate":1},{"cnt":[[245,1661],[1867,1661],[1867,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1660,"width":1623,"height":49},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"864884fac9c74eff9cba2c1121185610","type":"text","conversion_output":true,"text":"be done early and safely. Two of the studies included high intensity exercise very early after hip","text_display":" be done early and safely. Two of the studies included high intensity exercise very early after hip","confidence":1,"confidence_rate":1},{"cnt":[[245,1704],[1659,1704],[1659,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1703,"width":1415,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3d68f24b30c4da5aba82697f5892fdf","type":"text","conversion_output":true,"text":"fracture. \\({ }^{55,56}\\) Strength, gait speed, balance, and balance confidence improved in the","text_display":" fracture. \\({ }^{55,56}\\) Strength, gait speed, balance, and balance confidence improved in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1747],[1781,1747],[1781,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1746,"width":1538,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19acb67b04514659aabb3ec230a6cf46","type":"text","conversion_output":true,"text":"experimental groups. The third trial, \\({ }^{26}\\) which included aerobic conditioning during in-patient","text_display":" experimental groups. The third trial, \\({ }^{26}\\) which included aerobic conditioning during in-patient","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1858,1792],[1858,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1615,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b621a3c13544d20bbef5d937279eae1","type":"text","conversion_output":true,"text":"rehabilitation, demonstrated improved endurance ( \\(VO _{2}\\) peak), increased mobility, and improved","text_display":" rehabilitation, demonstrated improved endurance ( \\(VO _{2}\\) peak), increased mobility, and improved","confidence":0.8507308959960938,"confidence_rate":0.9985446688397462},{"cnt":[[245,1835],[397,1835],[397,1878],[245,1878]],"region":{"top_left_x":244,"top_left_y":1834,"width":154,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"692fa3552b7e4adfb96ac54a652e1434","type":"text","conversion_output":true,"text":"balance.","text_display":" balance.","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1755,1921],[1755,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1920,"width":1512,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9782f330ebe54fa6bf8995178cd98d3e","type":"text","conversion_output":true,"text":"The other clinical trials began six months or later after hip fracture, with interventions that","text_display":"\n\nThe other clinical trials began six months or later after hip fracture, with interventions that","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1824,1968],[1824,2015],[245,2015]],"region":{"top_left_x":244,"top_left_y":1967,"width":1581,"height":49},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c2be7cdbc3947648743267f714ee051","type":"text","conversion_output":true,"text":"included various combinations of strengthening exercise, balance training, functional training,","text_display":" included various combinations of strengthening exercise, balance training, functional training,","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1846,2011],[1846,2058],[245,2058]],"region":{"top_left_x":244,"top_left_y":2010,"width":1602,"height":49},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f18a138dcad247b0a3b9dc477e1c1078","type":"text","conversion_output":true,"text":"and AROM/flexibility. Three of these included endurance training but lacked at least one of the","text_display":" and AROM/flexibility. Three of these included endurance training but lacked at least one of the","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1880,2054],[1880,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2053,"width":1636,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc7d3e21587d4fa89fc646ef7266c46b","type":"text","conversion_output":true,"text":"other components of the program we are proposing. Results show positive outcomes in terms of","text_display":" other components of the program we are proposing. Results show positive outcomes in terms of","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,2097],[1807,2097],[1807,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2096,"width":1563,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7eb8edc8350499db55f4181039f97f3","type":"text","conversion_output":true,"text":"function, gait speed, balance, strength, and endurance. \\({ }^{22,29,63-68}\\) A study conducted in a gym","text_display":" function, gait speed, balance, strength, and endurance. \\({ }^{22,29,63-68}\\) A study conducted in a gym","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[245,2144],[1858,2144],[1858,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1615,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c7dc8142bdb48be9b29e9b09737faaa","type":"text","conversion_output":true,"text":"demonstrated improvement in self-reported outdoor mobility in the intervention group who were","text_display":" demonstrated improvement in self-reported outdoor mobility in the intervention group who were","confidence":1,"confidence_rate":1},{"cnt":[[245,2187],[1772,2187],[1772,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2187,"width":1529,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42c1ca7fca7b4750a810de28b5927b79","type":"text","conversion_output":true,"text":"four years post-fracture, but no changes in dynamic balance or walking speed. \\({ }^{69}\\) Since hip","text_display":" four years post-fracture, but no changes in dynamic balance or walking speed. \\({ }^{69}\\) Since hip","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1846,2230],[1846,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1602,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"687a77b608424f98895356f29b146c85","type":"text","conversion_output":true,"text":"fracture recovery is reported to plateau at six months (which is when the interventions in these","text_display":" fracture recovery is reported to plateau at six months (which is when the interventions in these","confidence":1,"confidence_rate":1},{"cnt":[[245,2275],[1850,2275],[1850,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2275,"width":1606,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d98b40cf26d045ad829c183b8f4dec42","type":"text","conversion_output":true,"text":"studies began), the results of these studies are comparable to the exercise findings reported in","text_display":" studies began), the results of these studies are comparable to the exercise findings reported in","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1794,2320],[1794,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2320,"width":1550,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08324097093841e294f7097944bd4f41","type":"text","conversion_output":true,"text":"older adults without hip fracture, i.e., that older adults benefit from increased activity. These","text_display":" older adults without hip fracture, i.e., that older adults benefit from increased activity. These","confidence":1,"confidence_rate":1},{"cnt":[[245,2363],[1768,2363],[1768,2411],[245,2411]],"region":{"top_left_x":244,"top_left_y":2363,"width":1525,"height":48},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4866a9be2809453d87eba964574a11f1","type":"text","conversion_output":true,"text":"studies indicate that use of higher intensity exercise with endurance training beginning six","text_display":" studies indicate that use of higher intensity exercise with endurance training beginning six","confidence":1,"confidence_rate":1},{"cnt":[[245,2408],[1644,2408],[1644,2456],[245,2456]],"region":{"top_left_x":244,"top_left_y":2408,"width":1400,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7230a2b94047426284c4692a462347aa","type":"text","conversion_output":true,"text":"months post-fracture reduces impairments in precursors to community ambulation.","text_display":" months post-fracture reduces impairments in precursors to community ambulation.","confidence":1,"confidence_rate":1},{"cnt":[[245,2585],[662,2585],[662,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2584,"width":418,"height":40},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab2d0b600f494346a850bdb3d2a7686b","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cc5477d1eeb4df18e435b7e90c99182","type":"page_info","conversion_output":false,"text":"14","text_display":"","confidence":0.99951171875,"confidence_rate":0.9997558295653994}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-034","page":34,"lines":[{"cnt":[[245,249],[1811,249],[1811,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1568,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd21a93b512c4cbfaa2e4b035f3f6553","type":"text","conversion_output":true,"text":"The unanswered question is whether a higher intensity program performed as soon as usual","text_display":"\n\nThe unanswered question is whether a higher intensity program performed as soon as usual","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1764,296],[1764,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1520,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a05d48c18eb1401a8955706c66d906e6","type":"text","conversion_output":true,"text":"care is complete will return more people to community ambulation. Mangione described a","text_display":" care is complete will return more people to community ambulation. Mangione described a","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1811,339],[1811,387],[245,387]],"region":{"top_left_x":244,"top_left_y":339,"width":1568,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d0502cf73824fb4bdde2fcef292e536","type":"text","conversion_output":true,"text":"program that provided function, strength, balance, and endurance training to a single patient","text_display":" program that provided function, strength, balance, and endurance training to a single patient","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1742,382],[1742,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1499,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4f86ea4f7bf44be896dfd38f398c553","type":"text","conversion_output":true,"text":"three months post-fracture. \\({ }^{70}\\) The patient showed dramatic improvements in all physical","text_display":" three months post-fracture. \\({ }^{70}\\) The patient showed dramatic improvements in all physical","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1755,430],[1755,475],[245,475]],"region":{"top_left_x":244,"top_left_y":429,"width":1512,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37e97ddf4cad4d808989a5dd056115b6","type":"text","conversion_output":true,"text":"precursors to community ambulation. In addition, the recent pilot study of the intervention","text_display":" precursors to community ambulation. In addition, the recent pilot study of the intervention","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1663,473],[1663,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1419,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75f023037bd94c1ea63bce1bf6c86643","type":"text","conversion_output":true,"text":"resulted in a significant between-group difference in distance walked on the SMWT.","text_display":" resulted in a significant between-group difference in distance walked on the SMWT.","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1781,559],[1781,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1538,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb0fec9263b148dd8c01ea1f8cbdf3e5","type":"text","conversion_output":true,"text":"A limited number of studies have examined exercise programs post-hip fracture. The most","text_display":"\n\nA limited number of studies have examined exercise programs post-hip fracture. The most","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1818,602],[1818,647],[245,647]],"region":{"top_left_x":244,"top_left_y":601,"width":1574,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"468346d04e43409db119fbdd32889212","type":"text","conversion_output":true,"text":"successful in terms of strength, balance, and gait speed outcomes were completed over a 6-","text_display":" successful in terms of strength, balance, and gait speed outcomes were completed over a 6","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,645],[1824,645],[1824,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1581,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5caf6b345b04ea89e1de5afd479bae2","type":"text","conversion_output":true,"text":"month time period in an exercise center. \\({ }^{22,68}\\) The majority of the research published is fraught","text_display":"month time period in an exercise center. \\({ }^{22,68}\\) The majority of the research published is fraught","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,692],[1828,692],[1828,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1585,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77450e6498864b24bf34b7a2ff44528e","type":"text","conversion_output":true,"text":"with problems including lack of control groups, small samples, and inadequate exercise dose.","text_display":" with problems including lack of control groups, small samples, and inadequate exercise dose.","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1841,735],[1841,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1598,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00a418a9f0884f738afe0138f72c6a41","type":"text","conversion_output":true,"text":"Prior research suggests that more intensive multi-component training as soon as usual care is","text_display":" Prior research suggests that more intensive multi-component training as soon as usual care is","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[904,778],[904,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":661,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8939042b81bc4ca2b089be4e5f220b6a","type":"text","conversion_output":true,"text":"complete should be safe and effective.","text_display":" complete should be safe and effective.","confidence":1,"confidence_rate":1},{"cnt":[[271,864],[986,864],[986,915],[271,915]],"region":{"top_left_x":270,"top_left_y":863,"width":717,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff971a6fb0964c2f8c1c772f6289ddd3","type":"section_header","conversion_output":false,"children_ids":["2c0a122da801468a906a666d94d7735f"],"text":"","text_display":""},{"cnt":[[275,868],[982,868],[982,909],[275,909]],"region":{"top_left_x":275,"top_left_y":867,"width":707,"height":42},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c0a122da801468a906a666d94d7735f","type":"text","conversion_output":true,"parent_id":"ff971a6fb0964c2f8c1c772f6289ddd3","text":"5.3 Rationale for the Interventions","text_display":"\n\n\\subsection*{5.3 Rationale for the Interventions}","confidence":0.99951171875,"confidence_rate":0.9999877900620892},{"cnt":[[245,915],[1850,915],[1850,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1606,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cdb8eb67d284bcb83d2ee3026a20452","type":"text","conversion_output":true,"text":"The significant mobility disability that remains post-hip fracture is remarkable and may account","text_display":"\n\nThe significant mobility disability that remains post-hip fracture is remarkable and may account","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[1751,958],[1751,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":958,"width":1507,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64f57fd6984947c482ead7f05616b002","type":"text","conversion_output":true,"text":"for failure to return to effective community ambulation. Mangione et al. surveyed physical","text_display":" for failure to return to effective community ambulation. Mangione et al. surveyed physical","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1876,1001],[1876,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1632,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"778447caa19a446b9741f417d96c2158","type":"text","conversion_output":true,"text":"therapists nationally to describe usual home care physical therapy following in-patient sub-acute","text_display":" therapists nationally to describe usual home care physical therapy following in-patient sub-acute","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1790,1044],[1790,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":1546,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34f469b9048541d18e524cc549b02257","type":"text","conversion_output":true,"text":"care for hip fracture. \\({ }^{53}\\) The results indicated very similar care regardless of fracture fixation,","text_display":" care for hip fracture. \\({ }^{53}\\) The results indicated very similar care regardless of fracture fixation,","confidence":1,"confidence_rate":1},{"cnt":[[245,1089],[1824,1089],[1824,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1089,"width":1581,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe7700f0e69741029bbe657995d5956d","type":"text","conversion_output":true,"text":"weight-bearing status, time when physical therapy started, or geographic location. Functional","text_display":" weight-bearing status, time when physical therapy started, or geographic location. Functional","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[1725,1134],[1725,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1134,"width":1482,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ceba4e2165346feb24cee60742f073b","type":"text","conversion_output":true,"text":"training was one of the most frequently reported interventions. Most of the joint-specific","text_display":" training was one of the most frequently reported interventions. Most of the joint-specific","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1876,1177],[1876,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1177,"width":1632,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a4872c4bef6476dbc570ac0f5454f47","type":"text","conversion_output":true,"text":"therapeutic exercises reported involved AROM, with very few therapists reporting that they used","text_display":" therapeutic exercises reported involved AROM, with very few therapists reporting that they used","confidence":1,"confidence_rate":1},{"cnt":[[245,1222],[1867,1222],[1867,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1222,"width":1623,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca6feab2c9f34999a1487b5be473d1d8","type":"text","conversion_output":true,"text":"any form of resistance (manual, elastic bands, or weights) for a specific exercise. This study will","text_display":" any form of resistance (manual, elastic bands, or weights) for a specific exercise. This study will","confidence":1,"confidence_rate":1},{"cnt":[[245,1265],[1858,1265],[1858,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1265,"width":1615,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff7c385a3e234edbab3452e9c07a49ec","type":"text","conversion_output":true,"text":"compare the effect of two interventions that provide additional supervised exercise in the home","text_display":" compare the effect of two interventions that provide additional supervised exercise in the home","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1828,1311],[1828,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1310,"width":1585,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fddf444601df48969e51fd7c7481239f","type":"text","conversion_output":true,"text":"following completion of post-acute rehabilitation. One intervention will be specific in delivering","text_display":" following completion of post-acute rehabilitation. One intervention will be specific in delivering","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1818,1354],[1818,1401],[245,1401]],"region":{"top_left_x":244,"top_left_y":1353,"width":1574,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e506faa66ebc441ab7f09c1c357b37b6","type":"text","conversion_output":true,"text":"exercise focused on addressing the precursors of ambulation in the community (PUSH). The","text_display":" exercise focused on addressing the precursors of ambulation in the community (PUSH). The","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1687,1396],[1687,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1443,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91348760f9bc46f18ba354f34fdb4966","type":"text","conversion_output":true,"text":"other intervention (PULSE) will be non-specific and will be similar to the joint-specific","text_display":" other intervention (PULSE) will be non-specific and will be similar to the joint-specific","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1803,1439],[1803,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1559,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2fa015b941e463a976d65cfee0aac11","type":"text","conversion_output":true,"text":"therapeutic exercises described in the Mangione et al. trial \\({ }^{71}\\) and will add a modality for pain","text_display":" therapeutic exercises described in the Mangione et al. trial \\({ }^{71}\\) and will add a modality for pain","confidence":0.99658203125,"confidence_rate":0.9999691552203086},{"cnt":[[245,1482],[1858,1482],[1858,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1482,"width":1615,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19ef59f894c142d8a39648d7f83d9f9b","type":"text","conversion_output":true,"text":"relief. \\({ }^{72}\\) Since a systematic review indicates that the evidence is insufficient with respect to best","text_display":" relief. \\({ }^{72}\\) Since a systematic review indicates that the evidence is insufficient with respect to best","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1732,1530],[1732,1577],[245,1577]],"region":{"top_left_x":244,"top_left_y":1529,"width":1488,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b96383749e3a4582af4e8c1c60a057ed","type":"text","conversion_output":true,"text":"practices in rehabilitating hip fracture in older adults, both interventions are plausible for","text_display":" practices in rehabilitating hip fracture in older adults, both interventions are plausible for","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1042,1573],[1042,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1572,"width":798,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bca27a7047da48a98cf2cf3bb089a7e3","type":"text","conversion_output":true,"text":"improving mobility in patients after hip fracture.","text_display":" improving mobility in patients after hip fracture.","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1820,1659],[1820,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1658,"width":1576,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7cbc814ff6ef4c84aa686042b1d8facf","type":"text","conversion_output":true,"text":"PUSH. Older adults improve functional performance when engaging in high intensity multiple","text_display":"\n\nPUSH. Older adults improve functional performance when engaging in high intensity multiple","confidence":1,"confidence_rate":1},{"cnt":[[245,1704],[1837,1704],[1837,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1703,"width":1593,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abbcc1f33f64420dba0cd1127733c67a","type":"text","conversion_output":true,"text":"component interventions. \\({ }^{73-79}\\) Despite disagreement about exercise type, intensity, frequency,","text_display":" component interventions. \\({ }^{73-79}\\) Despite disagreement about exercise type, intensity, frequency,","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1876,1749],[1876,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1632,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68e76ee385ca4154a89a6c514110ee06","type":"text","conversion_output":true,"text":"duration, and mechanism, it is known that the older musculoskeletal system adapts to increased","text_display":" duration, and mechanism, it is known that the older musculoskeletal system adapts to increased","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1727,1792],[1727,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1791,"width":1484,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b514b9299734303bc9153c5a5214d00","type":"text","conversion_output":true,"text":"demand. \\({ }^{80}\\) Several randomized trials have reported effects of exercise interventions on","text_display":" demand. \\({ }^{80}\\) Several randomized trials have reported effects of exercise interventions on","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1796,1835],[1796,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1553,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00ae0bff2e6d4c1ca2bb43e7cab63538","type":"text","conversion_output":true,"text":"improved physical function, balance, endurance, mobility and/or falls in community-dwelling","text_display":" improved physical function, balance, endurance, mobility and/or falls in community-dwelling","confidence":1,"confidence_rate":1},{"cnt":[[245,1880],[1824,1880],[1824,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1879,"width":1581,"height":49},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"064e0cd73db248318f572f278525ca9a","type":"text","conversion_output":true,"text":"elders without hip fracture. \\({ }^{22,77,78,81-85}\\) Studies reporting positive outcomes had similar content","text_display":" elders without hip fracture. \\({ }^{22,77,78,81-85}\\) Studies reporting positive outcomes had similar content","confidence":0.99658203125,"confidence_rate":0.9999699669128482},{"cnt":[[245,1925],[1755,1925],[1755,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1512,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57bd3c2c9e51445285287d6ddd05f451","type":"text","conversion_output":true,"text":"(strength, balance, and endurance), used high exercise intensity, and the exercises were","text_display":" (strength, balance, and endurance), used high exercise intensity, and the exercises were","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1841,1968],[1841,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1967,"width":1598,"height":47},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"508f1d73ca2a459d9b317009236b2cd2","type":"text","conversion_output":true,"text":"tailored to the individual's needs rather than using a generic protocol. Task-oriented functional","text_display":" tailored to the individual's needs rather than using a generic protocol. Task-oriented functional","confidence":0.974609375,"confidence_rate":0.9997478893412346},{"cnt":[[245,2011],[1841,2011],[1841,2058],[245,2058]],"region":{"top_left_x":244,"top_left_y":2010,"width":1598,"height":49},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a00a2f5c5230482f8e987f63e5e14369","type":"text","conversion_output":true,"text":"activities \\({ }^{81,83}\\) were more effective in achieving positive outcomes than traditional regimens that","text_display":" activities \\({ }^{81,83}\\) were more effective in achieving positive outcomes than traditional regimens that","confidence":0.99853515625,"confidence_rate":0.9999870273612914},{"cnt":[[245,2056],[1803,2056],[1803,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2056,"width":1559,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f58c5900e2d24b8d95f8dd92cb038f28","type":"text","conversion_output":true,"text":"included isometric or isotonic strength training, static standing balance training, and/or cycle","text_display":" included isometric or isotonic strength training, static standing balance training, and/or cycle","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[501,2097],[501,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2096,"width":257,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81381e59c472428dafde88d9ca0ff55c","type":"text","conversion_output":true,"text":"ergometry. \\({ }^{77,82}\\)","text_display":" ergometry. \\({ }^{77,82}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,2187],[1742,2187],[1742,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2187,"width":1499,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99aa30acbf354c3787238fc53962a725","type":"text","conversion_output":true,"text":"Principles derived from exercise physiology will be used to determine the intensity of the","text_display":"\n\nPrinciples derived from exercise physiology will be used to determine the intensity of the","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1811,2230],[1811,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1568,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a23abfa030d4de08d45c604d5c3eb3b","type":"text","conversion_output":true,"text":"endurance and muscle performance exercises. 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According to the overload principle, exercise","confidence":1,"confidence_rate":1},{"cnt":[[245,2275],[1738,2275],[1738,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2275,"width":1495,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16a5742efd5f4c538788cb2d13db3754","type":"text","conversion_output":true,"text":"should be performed at an intensity higher than the usual load to increase the metabolic","text_display":" should be performed at an intensity higher than the usual load to increase the metabolic","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1755,2316],[1755,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2316,"width":1512,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d853196161043a6ad8f8f5b22c81eba","type":"text","conversion_output":true,"text":"demand and facilitate a training response. \\({ }^{80,86-88}\\) Overload will be achieved by increasing","text_display":" demand and facilitate a training response. \\({ }^{80,86-88}\\) Overload will be achieved by increasing","confidence":1,"confidence_rate":1},{"cnt":[[245,2363],[1781,2363],[1781,2411],[245,2411]],"region":{"top_left_x":244,"top_left_y":2363,"width":1538,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d588864aa0a4821a509bf36d35c9702","type":"text","conversion_output":true,"text":"intensity (effort or load), or frequency and duration (number of repetitions, number of sets).","text_display":" intensity (effort or load), or frequency and duration (number of repetitions, number of sets).","confidence":1,"confidence_rate":1},{"cnt":[[245,2408],[1727,2408],[1727,2454],[245,2454]],"region":{"top_left_x":244,"top_left_y":2408,"width":1484,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16e17a6669ab41cb88dbf71fe320552c","type":"text","conversion_output":true,"text":"Manipulation of intensity, frequency, or duration alters the exercise dose - heart rate for","text_display":" Manipulation of intensity, frequency, or duration alters the exercise dose - heart rate for","confidence":1,"confidence_rate":1},{"cnt":[[245,2449],[1764,2449],[1764,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2449,"width":1520,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab7c47d6671b4f35a5b81cfc55e76ade","type":"text","conversion_output":true,"text":"endurance training or the amount of muscle force produced for muscle strengthening. \\({ }^{86} A\\)","text_display":" endurance training or the amount of muscle force produced for muscle strengthening. \\({ }^{86} A\\)","confidence":0.998046875,"confidence_rate":0.9999806434067887},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e082944c798841db85f6fe7e9dd09294","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3253ed0b43784ad79e12508342f75002","type":"page_info","conversion_output":false,"text":"15","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-035","page":35,"lines":[{"cnt":[[245,249],[1772,249],[1772,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1529,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"555870f40fad4dfab432359c785d34f2","type":"text","conversion_output":true,"text":"review and a meta-analysis emphasize the benefits of endurance training and progressive","text_display":"\nreview and a meta-analysis emphasize the benefits of endurance training and progressive","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1749,296],[1749,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1505,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e970369734ab42caa75fc47eebfb4f05","type":"text","conversion_output":true,"text":"resistance training for improvement in functional status, health, and quality of life in older","text_display":" resistance training for improvement in functional status, health, and quality of life in older","confidence":1,"confidence_rate":1},{"cnt":[[245,337],[1768,337],[1768,387],[245,387]],"region":{"top_left_x":244,"top_left_y":337,"width":1525,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e652a13f27f40e693f951f86ddd2f20","type":"text","conversion_output":true,"text":"adults. \\({ }^{89,90}\\) Guidelines suggested by these two reviews recommend combining endurance,","text_display":" adults. \\({ }^{89,90}\\) Guidelines suggested by these two reviews recommend combining endurance,","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1742,382],[1742,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1499,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1fcfc40f2cb4d2e83a115029553156e","type":"text","conversion_output":true,"text":"dynamic balance, and high intensity strength training, which is consistent with the PUSH","text_display":" dynamic balance, and high intensity strength training, which is consistent with the PUSH","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[460,425],[460,471],[245,471]],"region":{"top_left_x":244,"top_left_y":425,"width":216,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"905b4b3cc17a4a77b779564d9a490771","type":"text","conversion_output":true,"text":"intervention.","text_display":" intervention.","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1725,511],[1725,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1482,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22d206d198e146b5a33b6e3ebfd88337","type":"text","conversion_output":true,"text":"The specificity of training principle has been neglected in many hip fracture intervention","text_display":"\n\nThe specificity of training principle has been neglected in many hip fracture intervention","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1863,559],[1863,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1619,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f1f91b8a8e842e682743ba8c92626fb","type":"text","conversion_output":true,"text":"programs. Research suggests that the type of muscle contractions used during exercise should","text_display":" programs. Research suggests that the type of muscle contractions used during exercise should","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1807,602],[1807,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1563,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8747291997bc48768d57fb6ac164dba9","type":"text","conversion_output":true,"text":"match the type of contractions used in the desired activity to achieve the most gain. \\({ }^{80,86}\\) The","text_display":" match the type of contractions used in the desired activity to achieve the most gain. \\({ }^{80,86}\\) The","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[245,645],[1807,645],[1807,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1563,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e82296b51a74b8aa228aee720b3bcc0","type":"text","conversion_output":true,"text":"multi-component PUSH intervention will address endurance by requiring completion of task-","text_display":" multi-component PUSH intervention will address endurance by requiring completion of task","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1781,692],[1781,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1538,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82ce5d8c0d564a8f933b889a02624325","type":"text","conversion_output":true,"text":"specific activities for a continuous period of time. Muscle training will be addressed using a","text_display":"specific activities for a continuous period of time. Muscle training will be addressed using a","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1858,735],[1858,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1615,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"806196e0c72f4613a0fc5f00c8b0056f","type":"text","conversion_output":true,"text":"machine that provides progressive resistance training while the lower extremity performs whole","text_display":" machine that provides progressive resistance training while the lower extremity performs whole","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1869,778],[1869,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1626,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58a09bacf047497085c99db89e73dbec","type":"text","conversion_output":true,"text":"limb patterns similar to those used in walking. Upright balance will be challenged in combination","text_display":" limb patterns similar to those used in walking. Upright balance will be challenged in combination","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1852,821],[1852,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1608,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e137c6e05dd44ecd80d0016d83133bb6","type":"text","conversion_output":true,"text":"with muscle training. Although there is evidence that appropriate training increases endurance","text_display":" with muscle training. Although there is evidence that appropriate training increases endurance","confidence":1,"confidence_rate":1},{"cnt":[[245,866],[1869,866],[1869,913],[245,913]],"region":{"top_left_x":244,"top_left_y":865,"width":1626,"height":49},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de3d9d2637744c72936adc00ddc63ae6","type":"text","conversion_output":true,"text":"and muscle performance, the mechanisms for adaptation in response to exercise in older adults","text_display":" and muscle performance, the mechanisms for adaptation in response to exercise in older adults","confidence":1,"confidence_rate":1},{"cnt":[[245,907],[1835,907],[1835,956],[245,956]],"region":{"top_left_x":244,"top_left_y":906,"width":1591,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a564aad698c488897a50f506a0236e5","type":"text","conversion_output":true,"text":"are still being clarified. \\({ }^{91-95}\\) Motor learning principles, theories associated with neural plasticity","text_display":" are still being clarified. \\({ }^{91-95}\\) Motor learning principles, theories associated with neural plasticity","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1783,954],[1783,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1540,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1048e2016ad74366951e6a1e374b328c","type":"text","conversion_output":true,"text":"and exercise physiology must all be considered in the design of an intervention focused on","text_display":" and exercise physiology must all be considered in the design of an intervention focused on","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1729,997],[1729,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1486,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7ee3abec8b54573a3bb10fc62a50a69","type":"text","conversion_output":true,"text":"increasing community ambulation. \\({ }^{80}\\) The older person with hip fracture is more complex","text_display":" increasing community ambulation. \\({ }^{80}\\) The older person with hip fracture is more complex","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1858,1042],[1858,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1615,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55641d2cf44f470387b838ba8686e3cf","type":"text","conversion_output":true,"text":"because of the significant newly acquired deconditioning, muscle atrophy, fracture healing, and","text_display":" because of the significant newly acquired deconditioning, muscle atrophy, fracture healing, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[681,1087],[681,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":438,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8bdc53d679f468982f3f24d90f2a412","type":"text","conversion_output":true,"text":"other metabolic changes.","text_display":" other metabolic changes.","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1848,1173],[1848,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1604,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3758917508b4cf9bc879fcc319ed776","type":"text","conversion_output":true,"text":"PULSE. The PULSE intervention emphasizes increased mobility through AROM exercises for","text_display":"\n\nPULSE. The PULSE intervention emphasizes increased mobility through AROM exercises for","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1828,1216],[1828,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1585,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c8f68f4c644490ba93d00892adb9aaa","type":"text","conversion_output":true,"text":"the whole body. In addition, this intervention will be supervised by a physical therapist so that","text_display":" the whole body. In addition, this intervention will be supervised by a physical therapist so that","confidence":1,"confidence_rate":1},{"cnt":[[245,1261],[1869,1261],[1869,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1261,"width":1626,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bafd62902d9e40c1b6c78530f039c496","type":"text","conversion_output":true,"text":"participants perform techniques correctly and proper breathing is ensured throughout. Following","text_display":" participants perform techniques correctly and proper breathing is ensured throughout. Following","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1755,1306],[1755,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1512,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af2692d73c4945f1aeff2c1cf043ae25","type":"text","conversion_output":true,"text":"hip fracture, lower extremity muscle strength is reduced. Many factors have been cited to","text_display":" hip fracture, lower extremity muscle strength is reduced. Many factors have been cited to","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1742,1349],[1742,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1349,"width":1499,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b1411253f8d433e85aabb741f8fefc0","type":"text","conversion_output":true,"text":"account for this impairment including inactivity, fear of moving the injured limb, and pain.","text_display":" account for this impairment including inactivity, fear of moving the injured limb, and pain.","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[1841,1392],[1841,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1598,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8eeae38b08d4b139a513196cfc3d93a","type":"text","conversion_output":true,"text":"Arthrogenic muscle response (AMR), defined as an ongoing reflex reaction of the musculature","text_display":" Arthrogenic muscle response (AMR), defined as an ongoing reflex reaction of the musculature","confidence":1,"confidence_rate":1},{"cnt":[[245,1437],[1792,1437],[1792,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1437,"width":1548,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddc155cdc15a4d029aa39c9ed379c62e","type":"text","conversion_output":true,"text":"surrounding a joint after distension or damage to structures of that joint, is another reported","text_display":" surrounding a joint after distension or damage to structures of that joint, is another reported","confidence":1,"confidence_rate":1},{"cnt":[[245,1480],[1738,1480],[1738,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1480,"width":1495,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3bf9d28a29c4b1694bc5344fd7cd329","type":"text","conversion_output":true,"text":"consequence of joint injury. \\({ }^{71}\\) AMR has been suggested to be the result of inhibition of a","text_display":" consequence of joint injury. \\({ }^{71}\\) AMR has been suggested to be the result of inhibition of a","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1846,1525],[1846,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1602,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f7944c439d44eb8b7f3aaeeeeddcbdf","type":"text","conversion_output":true,"text":"muscle's motoneuron pool excitability and appears to be independent of pain and swelling and","text_display":" muscle's motoneuron pool excitability and appears to be independent of pain and swelling and","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1775,1568],[1775,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1531,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d755262a3a904781b71f0ab749501004","type":"text","conversion_output":true,"text":"may persist after the acute injury has resolved. A current hypothesis is that AMR occurs in","text_display":" may persist after the acute injury has resolved. A current hypothesis is that AMR occurs in","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1777,1611],[1777,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1533,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3261270e4d2b4eb3a2d287e9c7d647c5","type":"text","conversion_output":true,"text":"response to distorted articular sensory receptors after joint injury. Although AMR has been","text_display":" response to distorted articular sensory receptors after joint injury. Although AMR has been","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1854,1659],[1854,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1611,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7935f6e9f2464fe1a66dc9d75a4549e7","type":"text","conversion_output":true,"text":"studied in the knee, shoulder, elbow and ankle, this response may also occur in the hip muscle","text_display":" studied in the knee, shoulder, elbow and ankle, this response may also occur in the hip muscle","confidence":1,"confidence_rate":1},{"cnt":[[245,1697],[1878,1697],[1878,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1697,"width":1634,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e1a04c9374f4e89ba358760782c00d3","type":"text","conversion_output":true,"text":"following hip fracture and surgical repair. One reason, therefore, that TENS will be applied to the","text_display":" following hip fracture and surgical repair. One reason, therefore, that TENS will be applied to the","confidence":1,"confidence_rate":1},{"cnt":[[245,1745],[1867,1745],[1867,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1744,"width":1623,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"566a8e8cd1684394a9c2fd95c8d9c0b5","type":"text","conversion_output":true,"text":"gluteal, quadriceps, and gastroc-soleus muscles is to promote somatosensory input; the goal of","text_display":" gluteal, quadriceps, and gastroc-soleus muscles is to promote somatosensory input; the goal of","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1807,1788],[1807,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1563,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3e22771d5c141648c66745ad14eb9e7","type":"text","conversion_output":true,"text":"this input is to induce changes in the excitability of the motor neurons and to somatosensory","text_display":" this input is to induce changes in the excitability of the motor neurons and to somatosensory","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[1231,1830],[1231,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1830,"width":988,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a305db2c75da468392ddd32778464e25","type":"text","conversion_output":true,"text":"motor cortex to assist in activation of the motor neurons. \\({ }^{96}\\)","text_display":" motor cortex to assist in activation of the motor neurons. \\({ }^{96}\\)","confidence":0.99853515625,"confidence_rate":0.9999796402394503},{"cnt":[[245,1921],[1768,1921],[1768,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1525,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ff58f676f7f49188e1bc68e659d261b","type":"text","conversion_output":true,"text":"The other reason that we are proposing the use of TENS is to assist in pain management.","text_display":"\n\nThe other reason that we are proposing the use of TENS is to assist in pain management.","confidence":1,"confidence_rate":1},{"cnt":[[245,1962],[1807,1962],[1807,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1961,"width":1563,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aae173b73dc94f4da6c58c55e10e01b8","type":"text","conversion_output":true,"text":"Herrick et al (2004) grouped persons with hip fracture as moderate/severe or mild/no pain. \\({ }^{97}\\)","text_display":" Herrick et al (2004) grouped persons with hip fracture as moderate/severe or mild/no pain. \\({ }^{97}\\)","confidence":0.967803955078125,"confidence_rate":0.9996853789462564},{"cnt":[[245,2007],[1876,2007],[1876,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1632,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1b8f4e281d04f2f97259d5792c64f84","type":"text","conversion_output":true,"text":"Forty-two percent of the sample reported moderate/severe pain at baseline. The other benefit of","text_display":" Forty-two percent of the sample reported moderate/severe pain at baseline. The other benefit of","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1781,2054],[1781,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2053,"width":1538,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9a6887b7a7c4c709b1040343768f4d4","type":"text","conversion_output":true,"text":"TENS will be to reduce pain which may lead to an increased activity level. TENS has been","text_display":" TENS will be to reduce pain which may lead to an increased activity level. TENS has been","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1708,2097],[1708,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1465,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"acbb43bc4fa64460b9555b87a67516a2","type":"text","conversion_output":true,"text":"demonstrated to be effective in managing both acute and chronic pain for a number of","text_display":" demonstrated to be effective in managing both acute and chronic pain for a number of","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1790,2140],[1790,2187],[245,2187]],"region":{"top_left_x":244,"top_left_y":2139,"width":1546,"height":49},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6264406eb924306bec03ae4ff748e63","type":"text","conversion_output":true,"text":"conditions. Cheing and Hui-Chan (2004), for example, reported that TENS alone applied to","text_display":" conditions. Cheing and Hui-Chan (2004), for example, reported that TENS alone applied to","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1867,2183],[1867,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2182,"width":1623,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37a293964f8346718af1bad047bd649f","type":"text","conversion_output":true,"text":"persons with chronic pain secondary to knee osteoarthritis resulted in an increase in knee ROM","text_display":" persons with chronic pain secondary to knee osteoarthritis resulted in an increase in knee ROM","confidence":1,"confidence_rate":1},{"cnt":[[245,2226],[1777,2226],[1777,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2225,"width":1533,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0806be81cfb4340982483872f456b64","type":"text","conversion_output":true,"text":"during walking and increased gait speed. \\({ }^{98}\\) TENS was compared with a sham control after","text_display":" during walking and increased gait speed. \\({ }^{98}\\) TENS was compared with a sham control after","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1824,2273],[1824,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1581,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04092ecb2c39445cb43a5ec810d7094f","type":"text","conversion_output":true,"text":"surgical repair of hip fracture. When TENS was applied after surgery, pain on movement was","text_display":" surgical repair of hip fracture. When TENS was applied after surgery, pain on movement was","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1869,2316],[1869,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":1626,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43a97925f9ca4d94a528bf7c7452b7ad","type":"text","conversion_output":true,"text":"reduced and health-related quality of life improved. \\({ }^{99}\\) Gorodetskyi (2007) compared the effect of","text_display":" reduced and health-related quality of life improved. \\({ }^{99}\\) Gorodetskyi (2007) compared the effect of","confidence":1,"confidence_rate":1},{"cnt":[[245,2359],[1850,2359],[1850,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2358,"width":1606,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35e2a2e7c0e243dfa201d70606588295","type":"text","conversion_output":true,"text":"electrical stimulation to a sham control in 60 older people during acute hospitalization following","text_display":" electrical stimulation to a sham control in 60 older people during acute hospitalization following","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,2402],[1781,2402],[1781,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1538,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f10a2c6c2d0466d85a7aef41acc79ad","type":"text","conversion_output":true,"text":"hip fracture repair. \\({ }^{100}\\) Participants receiving electrical stimulation reported substantially and","text_display":" hip fracture repair. \\({ }^{100}\\) Participants receiving electrical stimulation reported substantially and","confidence":1,"confidence_rate":1},{"cnt":[[245,2447],[1807,2447],[1807,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2447,"width":1563,"height":48},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4a2362e2e2f47bead3505532ac95f1e","type":"text","conversion_output":true,"text":"significantly less interference from pain on walking ability after each of the 10 sessions. Pain","text_display":" significantly less interference from pain on walking ability after each of the 10 sessions. Pain","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ca00ed1737246d3bfa3ea2ce423e5ad","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5d9116c5422424da47726319614b100","type":"page_info","conversion_output":false,"text":"16","text_display":"","confidence":0.9990234375,"confidence_rate":0.9995115994824673}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-036","page":36,"lines":[{"cnt":[[245,251],[1846,251],[1846,299],[245,299]],"region":{"top_left_x":244,"top_left_y":251,"width":1602,"height":48},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0942f9ea692f448198b6fb640b0df063","type":"text","conversion_output":true,"text":"scores, which decreased over the 10-day treatment period in both groups, were also markedly","text_display":"\nscores, which decreased over the 10-day treatment period in both groups, were also markedly","confidence":0.50390625,"confidence_rate":0.9928862045195326},{"cnt":[[245,296],[1871,296],[1871,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1628,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbb324e694664af2a9b797becf3d3f22","type":"text","conversion_output":true,"text":"less in the electrical stimulation group. The two studies that have examined the use of TENS for","text_display":" less in the electrical stimulation group. The two studies that have examined the use of TENS for","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1878,339],[1878,387],[245,387]],"region":{"top_left_x":244,"top_left_y":339,"width":1634,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"146738611e354ee0a39b4f1fa7696e72","type":"text","conversion_output":true,"text":"pain alleviation have not, however, examined its effect on alleviation of the chronic pain reported","text_display":" pain alleviation have not, however, examined its effect on alleviation of the chronic pain reported","confidence":0.99658203125,"confidence_rate":0.9999670791635416},{"cnt":[[245,382],[741,382],[741,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":498,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69a8875454a34b81b7d8650ccd67cf21","type":"text","conversion_output":true,"text":"by persons after hip fracture.","text_display":" by persons after hip fracture.","confidence":1,"confidence_rate":1},{"cnt":[[269,464],[913,464],[913,526],[269,526]],"region":{"top_left_x":268,"top_left_y":464,"width":646,"height":63},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1ba4a2294784a76b67bd8dec6bcc809","type":"section_header","conversion_output":false,"children_ids":["39df71192d7a431eb2dc674aaffc9873"],"text":"","text_display":""},{"cnt":[[275,471],[909,471],[909,522],[275,522]],"region":{"top_left_x":275,"top_left_y":470,"width":634,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39df71192d7a431eb2dc674aaffc9873","type":"text","conversion_output":true,"parent_id":"f1ba4a2294784a76b67bd8dec6bcc809","text":"5.4 Primary Outcome Measure","text_display":"\n\n\\subsection*{5.4 Primary Outcome Measure}","confidence":1,"confidence_rate":1},{"cnt":[[245,518],[1837,518],[1837,565],[245,565]],"region":{"top_left_x":244,"top_left_y":517,"width":1593,"height":49},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5cd8cee92c394edba948313199e99eac","type":"text","conversion_output":true,"text":"Community ambulation is a construct that includes the ability to accommodate change in level","text_display":"\n\nCommunity ambulation is a construct that includes the ability to accommodate change in level","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1781,563],[1781,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1538,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"020da15ee3bc4158944be5a66d153959","type":"text","conversion_output":true,"text":"and terrain irregularity (necessary to enter and leave the home and for curb management),","text_display":" and terrain irregularity (necessary to enter and leave the home and for curb management),","confidence":0.9990236759185791,"confidence_rate":0.9999896085540316},{"cnt":[[245,606],[1820,606],[1820,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1576,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dcfb6a9406f648af90de43dd16f38fdf","type":"text","conversion_output":true,"text":"avoid obstacles and walk a requisite distance. \\({ }^{101}\\) Compared to older adults who are active in","text_display":" avoid obstacles and walk a requisite distance. \\({ }^{101}\\) Compared to older adults who are active in","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1749,649],[1749,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":1505,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24affb2def274beaacf4e606f9567fcf","type":"text","conversion_output":true,"text":"the community, persons with a mobility disability do not travel alone, take fewer trips and","text_display":" the community, persons with a mobility disability do not travel alone, take fewer trips and","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1846,692],[1846,741],[245,741]],"region":{"top_left_x":244,"top_left_y":691,"width":1602,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b0e9aceb7bb48cf954ce87aba2d7fcf","type":"text","conversion_output":true,"text":"perform fewer activities per trip, walk shorter distances, cross the street less often, carry fewer","text_display":" perform fewer activities per trip, walk shorter distances, cross the street less often, carry fewer","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[1725,739],[1725,784],[245,784]],"region":{"top_left_x":244,"top_left_y":739,"width":1482,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7775cd01f4504640afc208710903009e","type":"text","conversion_output":true,"text":"objects, and have fewer postural transitions (turning the head, extending their reach, or","text_display":" objects, and have fewer postural transitions (turning the head, extending their reach, or","confidence":1,"confidence_rate":1},{"cnt":[[245,780],[1878,780],[1878,829],[245,829]],"region":{"top_left_x":244,"top_left_y":779,"width":1634,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c278823eee1481fa8458196ba2cb640","type":"text","conversion_output":true,"text":"changing direction). \\({ }^{102}\\) Although community ambulation is complex, covering a minimal distance","text_display":" changing direction). \\({ }^{102}\\) Although community ambulation is complex, covering a minimal distance","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1205,825],[1205,872],[245,872]],"region":{"top_left_x":244,"top_left_y":825,"width":962,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74741b2569df4b29a216b09479cfccf9","type":"text","conversion_output":true,"text":"within a specified period of time is a critical feature. \\({ }^{103,104}\\)","text_display":" within a specified period of time is a critical feature. \\({ }^{103,104}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,913],[1790,913],[1790,960],[245,960]],"region":{"top_left_x":244,"top_left_y":913,"width":1546,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0ba143577d84e38b0ec4a0fca009371","type":"text","conversion_output":true,"text":"The SMWT is a standardized test that examines both the distance and time components of","text_display":"\n\nThe SMWT is a standardized test that examines both the distance and time components of","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[245,954],[1871,954],[1871,1005],[245,1005]],"region":{"top_left_x":244,"top_left_y":953,"width":1628,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2088a86fa2d842e3a6f03143a35c1aba","type":"text","conversion_output":true,"text":"community ambulation. \\({ }^{105}\\) The Cardiovascular Health Study \\({ }^{106}\\) concluded that the SMWT is safe","text_display":" community ambulation. \\({ }^{105}\\) The Cardiovascular Health Study \\({ }^{106}\\) concluded that the SMWT is safe","confidence":0.9975595474243164,"confidence_rate":0.9999792931352891},{"cnt":[[245,1001],[1854,1001],[1854,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1611,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f672aa732234711b5d1851b0dfe4ab1","type":"text","conversion_output":true,"text":"for use in community samples to measure the impact of multiple comorbidities on endurance in","text_display":" for use in community samples to measure the impact of multiple comorbidities on endurance in","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1775,1044],[1775,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":1531,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e284b91155dc45babab5237f86d62c92","type":"text","conversion_output":true,"text":"older adults. \\({ }^{31}\\) Harada et al \\({ }^{107}\\) proposed that the SMWT is a useful integrated measure of","text_display":" older adults. \\({ }^{31}\\) Harada et al \\({ }^{107}\\) proposed that the SMWT is a useful integrated measure of","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1815,1087],[1815,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1572,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01ed188e95f340a0b4a16b00f06f4f23","type":"text","conversion_output":true,"text":"mobility function taking into account any limitations imposed by major body systems. \\({ }^{107}\\) Lord","text_display":" mobility function taking into account any limitations imposed by major body systems. \\({ }^{107}\\) Lord","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1785,1130],[1785,1182],[245,1182]],"region":{"top_left_x":244,"top_left_y":1130,"width":1542,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c6c14ab0e2840eaba658fa6c65b65aa","type":"text","conversion_output":true,"text":"and Menz \\({ }^{108}\\) concluded that the SMWT provides a measure of overall mobility and physical","text_display":" and Menz \\({ }^{108}\\) concluded that the SMWT provides a measure of overall mobility and physical","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1764,1177],[1764,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1177,"width":1520,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47601082d8fb4a98836d4b11547d3829","type":"text","conversion_output":true,"text":"function in addition to being a measure of cardiovascular fitness. Sixty-nine percent of the","text_display":" function in addition to being a measure of cardiovascular fitness. Sixty-nine percent of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1760,1220],[1760,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1220,"width":1516,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"089d56ea7abc4f078b6735442cb8f622","type":"text","conversion_output":true,"text":"variance in the SMWT is explained by physical functioning, lower body strength, standing","text_display":" variance in the SMWT is explained by physical functioning, lower body strength, standing","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1800,1263],[1800,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1263,"width":1557,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"944128c21b2f41ebaf63e27db0ad316f","type":"text","conversion_output":true,"text":"balance, and gait speed. \\({ }^{107}\\) Construct and predictive validity and responsiveness to change","text_display":" balance, and gait speed. \\({ }^{107}\\) Construct and predictive validity and responsiveness to change","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1848,1306],[1848,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1306,"width":1604,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98e290fc5fd24498963e21ec5d707f83","type":"text","conversion_output":true,"text":"were established for the SMWT in a sample of 108 persons with hip fracture. \\({ }^{109}\\) A high positive","text_display":" were established for the SMWT in a sample of 108 persons with hip fracture. \\({ }^{109}\\) A high positive","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1833,1354],[1833,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1589,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d2057985411493a82785d509d117857","type":"text","conversion_output":true,"text":"correlation was reported between pedometer-determined physical activity and the SMWT test","text_display":" correlation was reported between pedometer-determined physical activity and the SMWT test","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1876,1396],[1876,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1632,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfd6a302891f4151a546d30590014342","type":"text","conversion_output":true,"text":"suggesting that both are correlates of community ambulation. \\({ }^{110}\\) The SMWT also has been used","text_display":" suggesting that both are correlates of community ambulation. \\({ }^{110}\\) The SMWT also has been used","confidence":0.9912109375,"confidence_rate":0.999917499533037},{"cnt":[[245,1439],[1785,1439],[1785,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1542,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"556fe8be637849e0a9a3fcefe57318e6","type":"text","conversion_output":true,"text":"as an outcome measure to determine the effectiveness of exercise interventions for elderly","text_display":" as an outcome measure to determine the effectiveness of exercise interventions for elderly","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[990,1482],[990,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1482,"width":747,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f334835e59f4977ab16ee55477c25c3","type":"text","conversion_output":true,"text":"patients with and without hip fracture. \\({ }^{29,63,111}\\)","text_display":" patients with and without hip fracture. \\({ }^{29,63,111}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1837,1573],[1837,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1572,"width":1593,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"610fae9f26ba41eeb5787ee9026b5a7e","type":"text","conversion_output":true,"text":"Distance. Some investigators use a 400 m threshold ( \\(2-3\\) city blocks) for the SMWT to identify","text_display":"\n\nDistance. Some investigators use a 400 m threshold ( \\(2-3\\) city blocks) for the SMWT to identify","confidence":0.9990234375,"confidence_rate":0.9999908688300274},{"cnt":[[245,1616],[1755,1616],[1755,1663],[245,1663]],"region":{"top_left_x":244,"top_left_y":1615,"width":1512,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"779d32ba0dd44a1b97f596e327f0ea5f","type":"text","conversion_output":true,"text":"community-dwelling elders at risk for developing a mobility disability. \\({ }^{27,82,107,108,112-114}\\) This","text_display":" community-dwelling elders at risk for developing a mobility disability. \\({ }^{27,82,107,108,112-114}\\) This","confidence":0.9907433845830838,"confidence_rate":0.9999177049429309},{"cnt":[[245,1659],[1833,1659],[1833,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1658,"width":1589,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"572d90bd32074e94a3cc890da8a76a69","type":"text","conversion_output":true,"text":"threshold appears valid to detect early decline in community dwelling elders. \\({ }^{27,31,82,107,108}\\) Four","text_display":" threshold appears valid to detect early decline in community dwelling elders. \\({ }^{27,31,82,107,108}\\) Four","confidence":0.9848773445701227,"confidence_rate":0.9998663407854451},{"cnt":[[245,1704],[1880,1704],[1880,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1703,"width":1636,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eef29c71d7754a5d8b537666b6784da5","type":"text","conversion_output":true,"text":"hundred meters, however, is considered too high for this investigation where the goal is to assist","text_display":" hundred meters, however, is considered too high for this investigation where the goal is to assist","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1691,1749],[1691,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1447,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddfdf316cedf464c8340990d3eb601f3","type":"text","conversion_output":true,"text":"participants, with a significant mobility disability due to recent hip fracture, to return to","text_display":" participants, with a significant mobility disability due to recent hip fracture, to return to","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1721,1792],[1721,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1791,"width":1477,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ee044b711f74daa8413935fa3d45b09","type":"text","conversion_output":true,"text":"community ambulation. Several investigators support a 300 m threshold for community","text_display":" community ambulation. Several investigators support a 300 m threshold for community","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1867,1835],[1867,1882],[245,1882]],"region":{"top_left_x":244,"top_left_y":1834,"width":1623,"height":49},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dee402829244c8f9fd4053584629448","type":"text","conversion_output":true,"text":"ambulation. \\({ }^{102,107}\\) Reasons to adopt a 300 m distance threshold on the SMWT test include: 1)","text_display":" ambulation. \\({ }^{102,107}\\) Reasons to adopt a 300 m distance threshold on the SMWT test include: 1)","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1876,1878],[1876,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1877,"width":1632,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b69bbc543904407aa06d20d342b65411","type":"text","conversion_output":true,"text":"at six months post-fracture or post-stroke, average group performance is \\(\\left.<300 m^{29,63,72,109,115} ; 2\\right)\\)","text_display":" at six months post-fracture or post-stroke, average group performance is \\(\\left.<300 m^{29,63,72,109,115} ; 2\\right)\\)","confidence":0.6462921865036524,"confidence_rate":0.996075257361661},{"cnt":[[245,1921],[1846,1921],[1846,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1920,"width":1602,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"470c0a403df34716aefbb13775007c54","type":"text","conversion_output":true,"text":"achieving < 300 m on the SMWT is a predictor of mortality; \\({ }^{28} 3\\) ) average distance from parking","text_display":" achieving < 300 m on the SMWT is a predictor of mortality; \\({ }^{28} 3\\) ) average distance from parking","confidence":0.508248515796776,"confidence_rate":0.9940808791273247},{"cnt":[[245,1968],[1880,1968],[1880,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1967,"width":1636,"height":47},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39f0d1aee7304aa7af24b8c1b929f2d8","type":"text","conversion_output":true,"text":"space in a supermarket parking lot to task completion in the supermarket in both urban and rural","text_display":" space in a supermarket parking lot to task completion in the supermarket in both urban and rural","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[677,2007],[677,2054],[245,2054]],"region":{"top_left_x":244,"top_left_y":2006,"width":433,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f705dd7ed2f8426aa7af98b771e9a4ea","type":"text","conversion_output":true,"text":"communities is \\(301 m .^{103}\\)","text_display":" communities is \\(301 m .^{103}\\)","confidence":0.6455078125,"confidence_rate":0.9882394865729859},{"cnt":[[245,2099],[1766,2099],[1766,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2099,"width":1523,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96aa1a19a24f41f59559cde062bf8d10","type":"text","conversion_output":true,"text":"Time. Usual walking speed has been determined from observing walking speeds of urban","text_display":"\n\nTime. Usual walking speed has been determined from observing walking speeds of urban","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1824,2141],[1824,2190],[245,2193]],"region":{"top_left_x":244,"top_left_y":2141,"width":1581,"height":52},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fa8a821ae974a98ae231472bf4cf003","type":"text","conversion_output":true,"text":"pedestrians and from human performance laboratory investigations. \\({ }^{116-120}\\) Functional walking","text_display":" pedestrians and from human performance laboratory investigations. \\({ }^{116-120}\\) Functional walking","confidence":0.9990236759185791,"confidence_rate":0.999990871060396},{"cnt":[[245,2187],[1863,2187],[1863,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2187,"width":1619,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb27187902fc47ca88c63064dacb3c8c","type":"text","conversion_output":true,"text":"categories have been developed to include the community walker (i.e., independent in all home","text_display":" categories have been developed to include the community walker (i.e., independent in all home","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1669,2230],[1669,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1426,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3121706a2484e56a290166798b39695","type":"text","conversion_output":true,"text":"and community activities). A reported gait speed of \\(0.8 m / s\\) signifies the community","text_display":" and community activities). A reported gait speed of \\(0.8 m / s\\) signifies the community","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1738,2273],[1738,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2273,"width":1495,"height":50},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"debdc73ede334f218b326edba0d1b46b","type":"text","conversion_output":true,"text":"walker. \\({ }^{121,122}\\) One year post-hip fracture, usual gait speeds range from 0.44 to \\(0.97 m / s\\),","text_display":" walker. \\({ }^{121,122}\\) One year post-hip fracture, usual gait speeds range from 0.44 to \\(0.97 m / s\\),","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1820,2316],[1820,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2316,"width":1576,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"519d975cbbac4225a02f165e4424c92b","type":"text","conversion_output":true,"text":"\\(29,33,56,57,64,72,123-125\\) the average of which is below the community ambulation threshold. Others","text_display":" \\(29,33,56,57,64,72,123-125\\) the average of which is below the community ambulation threshold. Others","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,2363],[1854,2363],[1854,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2363,"width":1611,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c6484a72b8a4543848347466cd8e4d7","type":"text","conversion_output":true,"text":"have reported that a speed threshold of \\(0.8 m / s\\) is a useful and discriminative primary endpoint","text_display":" have reported that a speed threshold of \\(0.8 m / s\\) is a useful and discriminative primary endpoint","confidence":1,"confidence_rate":1},{"cnt":[[245,2406],[975,2406],[975,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2406,"width":732,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7d8d6020c894585854883a681021235","type":"text","conversion_output":true,"text":"in clinical trials of exercise rehabilitation. \\({ }^{125}\\)","text_display":" in clinical trials of exercise rehabilitation. \\({ }^{125}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,2585],[660,2585],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2584,"width":416,"height":40},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0c7fe62eb6144298fb3b226fdd70293","type":"page_info","conversion_output":false,"text":"CAP Protocol version 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The SMWT is an assessment with excellent psychometric","confidence":0.9990234375,"confidence_rate":0.9999888973383643},{"cnt":[[245,296],[1729,296],[1729,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1486,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2f98db82b2344f29ae59fd949bc532d","type":"text","conversion_output":true,"text":"properties, and there is sound justification for a 300 m distance threshold on the SMWT","text_display":" properties, and there is sound justification for a 300 m distance threshold on the SMWT","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1785,339],[1785,389],[245,389]],"region":{"top_left_x":244,"top_left_y":339,"width":1542,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11c6d8cf2ca14357a6597156d52c2d53","type":"text","conversion_output":true,"text":"(equivalent to walking at \\(0.8 m / s\\) ) to serve as an indicator for community ambulatory ability.","text_display":" (equivalent to walking at \\(0.8 m / s\\) ) to serve as an indicator for community ambulatory ability.","confidence":1,"confidence_rate":1},{"cnt":[[269,421],[1811,421],[1811,483],[269,483]],"region":{"top_left_x":268,"top_left_y":421,"width":1544,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a081c8051014870b2635877fe580738","type":"section_header","conversion_output":false,"children_ids":["a02ec32a259c4bacb072d5f08fb01f92"],"text":"","text_display":""},{"cnt":[[275,430],[1807,430],[1807,479],[275,479]],"region":{"top_left_x":275,"top_left_y":429,"width":1532,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a02ec32a259c4bacb072d5f08fb01f92","type":"text","conversion_output":true,"parent_id":"2a081c8051014870b2635877fe580738","text":"5.5 Economic Evaluation of Interventions to Reduce Post-fracture Disability","text_display":"\n\n\\subsection*{5.5 Economic Evaluation of Interventions to Reduce Post-fracture Disability}","confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[245,473],[1695,473],[1695,522],[245,522]],"region":{"top_left_x":244,"top_left_y":472,"width":1452,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3f3379d8fdb41c388696cfe7ef82afb","type":"text","conversion_output":true,"text":"The economic consequences of hip fracture are substantial. \\({ }^{17}\\) In a society with limited","text_display":"\n\nThe economic consequences of hip fracture are substantial. \\({ }^{17}\\) In a society with limited","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1794,520],[1794,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":1550,"height":47},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12332a7924144d3bb104a5427de28948","type":"text","conversion_output":true,"text":"resources, each additional expenditure should produce a benefit that is worth the additional","text_display":" resources, each additional expenditure should produce a benefit that is worth the additional","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1751,563],[1751,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1507,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"740e19a453ed464a8ed2224a84b2b9e0","type":"text","conversion_output":true,"text":"cost. Although a number of studies have addressed the cost-effectiveness of hip fracture","text_display":" cost. Although a number of studies have addressed the cost-effectiveness of hip fracture","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1850,606],[1850,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1606,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b1af8b4a7584e5aa7ac8aa9f20a3346","type":"text","conversion_output":true,"text":"prevention through pharmacological and hip-protector interventions, \\({ }^{126-134}\\) the value of exercise","text_display":" prevention through pharmacological and hip-protector interventions, \\({ }^{126-134}\\) the value of exercise","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1858,649],[1858,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":1615,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ed4ecaa8ac94890af95d76f0f152a81","type":"text","conversion_output":true,"text":"interventions to reduce post-fracture disability has not been evaluated. Nonetheless, the role of","text_display":" interventions to reduce post-fracture disability has not been evaluated. Nonetheless, the role of","confidence":0.9990234375,"confidence_rate":0.9999904212258001},{"cnt":[[245,694],[1824,694],[1824,741],[245,741]],"region":{"top_left_x":244,"top_left_y":693,"width":1581,"height":49},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72a51ae32ccc4317835ce68f14a937e0","type":"text","conversion_output":true,"text":"post-fracture disability in overall economic costs is well-recognized as is the dearth of studies","text_display":" post-fracture disability in overall economic costs is well-recognized as is the dearth of studies","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1854,735],[1854,784],[245,784]],"region":{"top_left_x":244,"top_left_y":734,"width":1611,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f83888a099f446ebb51ab73ad1c4bfe7","type":"text","conversion_output":true,"text":"that have attempted to characterize indirect costs of fracture. \\({ }^{135}\\) Therefore, a secondary aim of","text_display":" that have attempted to characterize indirect costs of fracture. \\({ }^{135}\\) Therefore, a secondary aim of","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[245,782],[1837,782],[1837,829],[245,829]],"region":{"top_left_x":244,"top_left_y":782,"width":1593,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fedf32375d546919341cd4bddbd972b","type":"text","conversion_output":true,"text":"the study will be to assess the economic value of the interventions compared to each other as","text_display":" the study will be to assess the economic value of the interventions compared to each other as","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1781,825],[1781,872],[245,872]],"region":{"top_left_x":244,"top_left_y":825,"width":1538,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55ebdc21d27d4d73a345d45e212973f6","type":"text","conversion_output":true,"text":"well as the interventions compared to usual care. This evaluation will estimate the cost per","text_display":" well as the interventions compared to usual care. This evaluation will estimate the cost per","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1156,868],[1156,917],[245,917]],"region":{"top_left_x":244,"top_left_y":867,"width":912,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3a010b17d274a348e2baa6f4ac1b564","type":"text","conversion_output":true,"text":"additional quality-adjusted life year (QALY) gained. \\({ }^{136}\\)","text_display":" additional quality-adjusted life year (QALY) gained. \\({ }^{136}\\)","confidence":0.99951171875,"confidence_rate":0.9999927104668955},{"cnt":[[243,954],[819,954],[819,1021],[243,1021]],"region":{"top_left_x":242,"top_left_y":953,"width":577,"height":68},"line":16,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"2b55f338c34d48f49ce06749cd808043","type":"section_header","conversion_output":false,"children_ids":["ba23eee324004bf386b9cd008492b09b"],"text":"","text_display":""},{"cnt":[[245,958],[814,958],[814,1016],[245,1016]],"region":{"top_left_x":244,"top_left_y":958,"width":571,"height":59},"line":17,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"ba23eee324004bf386b9cd008492b09b","type":"text","conversion_output":true,"parent_id":"2b55f338c34d48f49ce06749cd808043","text":"Section 6: Study Design","text_display":"\n\n\\section*{Section 6: Study Design}","confidence":1,"confidence_rate":1},{"cnt":[[271,1074],[898,1074],[898,1137],[271,1137]],"region":{"top_left_x":270,"top_left_y":1074,"width":629,"height":63},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d377833cfdb4c259d1078ad5787ff5d","type":"section_header","conversion_output":false,"children_ids":["08b189b0a2a84116a41d2d44c65e82e4"],"text":"","text_display":""},{"cnt":[[275,1079],[892,1079],[892,1130],[275,1130]],"region":{"top_left_x":275,"top_left_y":1078,"width":617,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08b189b0a2a84116a41d2d44c65e82e4","type":"text","conversion_output":true,"parent_id":"4d377833cfdb4c259d1078ad5787ff5d","text":"6.1 Overview of Study Design","text_display":"\n\n\\subsection*{6.1 Overview of Study Design}","confidence":1,"confidence_rate":1},{"cnt":[[245,1126],[1768,1126],[1768,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1125,"width":1525,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66c8bdcf8ac24c45b9e73bca8e3f7565","type":"text","conversion_output":true,"text":"A RCT of 210 older adults who have experienced a hip fracture will be carried out at three","text_display":"\n\nA RCT of 210 older adults who have experienced a hip fracture will be carried out at three","confidence":1,"confidence_rate":1},{"cnt":[[245,1171],[1708,1171],[1708,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1170,"width":1465,"height":49},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25a132c3b5bd470eb156df5abbcd5614","type":"text","conversion_output":true,"text":"clinical sites (AU, UMB, and UCHC) with half of the subjects receiving a specific multi-","text_display":" clinical sites (AU, UMB, and UCHC) with half of the subjects receiving a specific multi","confidence":1,"confidence_rate":1},{"cnt":[[245,1214],[1794,1214],[1794,1261],[245,1261]],"region":{"top_left_x":244,"top_left_y":1213,"width":1550,"height":49},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a634f624990249c6913634546a400399","type":"text","conversion_output":true,"text":"component intervention (PUSH) and the other half receiving a non-specific multicomponent","text_display":"component intervention (PUSH) and the other half receiving a non-specific multicomponent","confidence":1,"confidence_rate":1},{"cnt":[[245,1259],[1785,1259],[1785,1304],[245,1304]],"region":{"top_left_x":244,"top_left_y":1258,"width":1542,"height":47},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e2d6627f6a7421fbccb0961294e9410","type":"text","conversion_output":true,"text":"intervention (PULSE). Randomization of 210 participants meeting eligibility criteria will take","text_display":" intervention (PULSE). Randomization of 210 participants meeting eligibility criteria will take","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[1858,1302],[1858,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1301,"width":1615,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2cae41354226457d89c18685760436d3","type":"text","conversion_output":true,"text":"place after post-acute rehabilitation ends, up to 26 weeks after admission to the hospital for hip","text_display":" place after post-acute rehabilitation ends, up to 26 weeks after admission to the hospital for hip","confidence":1,"confidence_rate":1},{"cnt":[[245,1345],[1861,1345],[1861,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1344,"width":1617,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d68d11ae307f436eadcf5fc5fd50d6d8","type":"text","conversion_output":true,"text":"fracture. The primary endpoint will be measured 16 weeks after randomization. Patients age 60","text_display":" fracture. The primary endpoint will be measured 16 weeks after randomization. Patients age 60","confidence":1,"confidence_rate":1},{"cnt":[[245,1388],[1867,1388],[1867,1437],[245,1437]],"region":{"top_left_x":244,"top_left_y":1387,"width":1623,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e7667e93d0e46db99d79818dc9e562a","type":"text","conversion_output":true,"text":"and older who have had surgical repair for hip fracture will be identified at the three clinical sites","text_display":" and older who have had surgical repair for hip fracture will be identified at the three clinical sites","confidence":0.9580078125,"confidence_rate":0.9995991518934697},{"cnt":[[245,1435],[1854,1435],[1854,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1435,"width":1611,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7a9954e58154502ae627417b9768e7d","type":"text","conversion_output":true,"text":"through a variety of recruitment sources and will be evaluated for eligibility. Following consent","text_display":" through a variety of recruitment sources and will be evaluated for eligibility. Following consent","confidence":1,"confidence_rate":1},{"cnt":[[245,1478],[1841,1478],[1841,1525],[245,1525]],"region":{"top_left_x":244,"top_left_y":1478,"width":1598,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b18faf9546b41e2b9b418dcecaff9bd","type":"text","conversion_output":true,"text":"to participate, eligible participants will undergo a comprehensive baseline assessment and will","text_display":" to participate, eligible participants will undergo a comprehensive baseline assessment and will","confidence":1,"confidence_rate":1},{"cnt":[[245,1521],[1843,1521],[1843,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1521,"width":1600,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dffcdc12b7de463490846ad5873b7865","type":"text","conversion_output":true,"text":"then be randomized to one of the two treatment groups. The cohort will be measured again 16","text_display":" then be randomized to one of the two treatment groups. The cohort will be measured again 16","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1564],[1878,1564],[1878,1613],[245,1613]],"region":{"top_left_x":244,"top_left_y":1564,"width":1634,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf5145e663b54b39ac8374493686ddd2","type":"text","conversion_output":true,"text":"weeks post-randomization. Figure 1 shows the sequence of participant contacts from the time of","text_display":" weeks post-randomization. Figure 1 shows the sequence of participant contacts from the time of","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,1609],[1704,1609],[1704,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1609,"width":1460,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e725b4615b624227908c104810e945b1","type":"text","conversion_output":true,"text":"hospitalization until the final assessment approximately 16 weeks after randomization.","text_display":" hospitalization until the final assessment approximately 16 weeks after randomization.","confidence":1,"confidence_rate":1},{"cnt":[[245,1697],[1280,1697],[1280,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1697,"width":1037,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0c8e588f22142d484daf4376395124d","type":"figure_label","conversion_output":false,"text":"Figure 1. Timeline for screening, randomization, and follow-up","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[196,1755],[1912,1755],[1912,2539],[196,2539]],"region":{"top_left_x":195,"top_left_y":1755,"width":1718,"height":785},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b17b99c90d7448c791bf067356e5a0e0","type":"diagram","conversion_output":true,"selected_labels":["e0c8e588f22142d484daf4376395124d"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 1. Timeline for screening, randomization, and follow-up}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/2efa872f-7404-4e9a-b558-82f18459fdff-037.jpg?height=785&width=1718&top_left_y=1755&top_left_x=195}\n\\end{figure}"},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ba6fccec60d442a877578198502ad54","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d074e42dcffe4b3db0541dbc475b569a","type":"page_info","conversion_output":false,"text":"18","text_display":"","confidence":0.99951171875,"confidence_rate":0.9997558295653994}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-038","page":38,"lines":[{"cnt":[[245,296],[1854,296],[1854,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1611,"height":46},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"560aec7200be483490e86032e199783b","type":"text","conversion_output":true,"text":"Within a week of randomization, participants will initiate the intervention with a PT in their place","text_display":"\n\nWithin a week of randomization, participants will initiate the intervention with a PT in their place","confidence":0.84814453125,"confidence_rate":0.9985172785182097},{"cnt":[[245,339],[1833,339],[1833,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1589,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64eaa9b9e975427083dd68d17dc021a8","type":"text","conversion_output":true,"text":"of residence and receive counseling with a registered dietician. The follow-up assessment will","text_display":" of residence and receive counseling with a registered dietician. The follow-up assessment will","confidence":1,"confidence_rate":1},{"cnt":[[245,385],[1803,385],[1803,432],[245,432]],"region":{"top_left_x":244,"top_left_y":384,"width":1559,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e5096eb235a4fa8bad96937e48481f6","type":"text","conversion_output":true,"text":"take place 16 weeks post-randomization. Telephone interviews will be conducted every four","text_display":" take place 16 weeks post-randomization. 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An honorarium will be given at the completion of both study assessment visits.","text_display":" participants. An honorarium will be given at the completion of both study assessment visits.","confidence":0.998046875,"confidence_rate":0.9999798452048033},{"cnt":[[247,604],[1811,604],[1811,647],[247,647]],"region":{"top_left_x":247,"top_left_y":603,"width":1565,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fb7ee05c42844e38dd0e6b4e7c4f37a","type":"text","conversion_output":true,"text":"For participants randomized prior to version 10.0 of the protocol, follow-up assessment visits","text_display":"\n\nFor participants randomized prior to version 10.0 of the protocol, follow-up assessment visits","confidence":1,"confidence_rate":1},{"cnt":[[247,647],[1876,647],[1876,694],[247,694]],"region":{"top_left_x":247,"top_left_y":646,"width":1629,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84b4888a252e41a285e3aae2e8c56e09","type":"text","conversion_output":true,"text":"occurred 16 weeks and 40 weeks from the date of randomization and telephone interviews were","text_display":" occurred 16 weeks and 40 weeks from the date of randomization and telephone interviews were","confidence":0.99365234375,"confidence_rate":0.9999375716714478},{"cnt":[[245,692],[1727,692],[1727,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1484,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c89b0d0511b343b5b2c87681e970b3e3","type":"text","conversion_output":true,"text":"conducted every four weeks during the 40-week study period for a total of 10 telephone","text_display":" conducted every four weeks during the 40-week study period for a total of 10 telephone","confidence":0.6452479362487793,"confidence_rate":0.9953499870833553},{"cnt":[[245,735],[432,735],[432,776],[245,776]],"region":{"top_left_x":244,"top_left_y":734,"width":188,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca75d1213b9f4341825664674e7122ff","type":"text","conversion_output":true,"text":"interviews.","text_display":" interviews.","confidence":1,"confidence_rate":1},{"cnt":[[271,821],[681,821],[681,870],[271,870]],"region":{"top_left_x":270,"top_left_y":820,"width":412,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53dcf255f2a3436e8cbdc33070ac744e","type":"section_header","conversion_output":false,"children_ids":["388df0e9588440c5b9d6fffc3e55fc36"],"text":"","text_display":""},{"cnt":[[277,821],[677,821],[677,866],[277,866]],"region":{"top_left_x":277,"top_left_y":820,"width":400,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"388df0e9588440c5b9d6fffc3e55fc36","type":"text","conversion_output":true,"parent_id":"53dcf255f2a3436e8cbdc33070ac744e","text":"6.2 Randomization","text_display":"\n\n\\subsection*{6.2 Randomization}","confidence":1,"confidence_rate":1},{"cnt":[[247,870],[1841,870],[1841,917],[247,917]],"region":{"top_left_x":247,"top_left_y":870,"width":1595,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4501e62cf2244e594af5c7746aece76","type":"text","conversion_output":true,"text":"Randomization will occur up to 26 weeks after admission to the hospital for a hip fracture. The","text_display":"\n\nRandomization will occur up to 26 weeks after admission to the hospital for a hip fracture. The","confidence":1,"confidence_rate":1},{"cnt":[[245,915],[1854,915],[1854,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1611,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0fbf659a157406d80bc2e9a77fd7be0","type":"text","conversion_output":true,"text":"randomization schedule for each clinical site will ensure that treatments are randomly assigned","text_display":" randomization schedule for each clinical site will ensure that treatments are randomly assigned","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[1790,958],[1790,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":958,"width":1546,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ad9308f3ecd4e37b698effb4d3f765b","type":"text","conversion_output":true,"text":"within blocks of \\(2,4,6\\), or 8 , with equal numbers of participants assigned to each treatment","text_display":" within blocks of \\(2,4,6\\), or 8 , with equal numbers of participants assigned to each treatment","confidence":0.9985356330871582,"confidence_rate":0.9999859093286404},{"cnt":[[245,1001],[1876,1001],[1876,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1632,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"532173db66a74f938443b8a15dce5e1f","type":"text","conversion_output":true,"text":"within each block. Block sizes (two to eight participants per block) will be randomly selected with","text_display":" within each block. Block sizes (two to eight participants per block) will be randomly selected with","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1205,1044],[1205,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":962,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa5368d8ff6345e5915b5d03c8d852c6","type":"text","conversion_output":true,"text":"the probability of each block size specified by DCC staff.","text_display":" the probability of each block size specified by DCC staff.","confidence":0.99951171875,"confidence_rate":0.9999922476411908},{"cnt":[[245,1134],[1693,1134],[1693,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1134,"width":1449,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7c198d871034ed2bddaac34e70fa1bc","type":"text","conversion_output":true,"text":"To ensure that those performing evaluations remain blinded to treatment assignment,","text_display":"\n\nTo ensure that those performing evaluations remain blinded to treatment assignment,","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1762,1177],[1762,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1177,"width":1518,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3588eba6707c4daeb896c604e2747462","type":"text","conversion_output":true,"text":"randomization will only be performed by appropriate unblinded study personnel who have","text_display":" randomization will only be performed by appropriate unblinded study personnel who have","confidence":1,"confidence_rate":1},{"cnt":[[245,1222],[1863,1222],[1863,1268],[245,1268]],"region":{"top_left_x":244,"top_left_y":1222,"width":1619,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f53cc472d784bfda536e7f57c138012","type":"text","conversion_output":true,"text":"received training and certification on randomization procedures. The clinical site PI , clinical site","text_display":" received training and certification on randomization procedures. The clinical site PI , clinical site","confidence":0.8165847819764167,"confidence_rate":0.9981924878773448},{"cnt":[[245,1265],[1841,1265],[1841,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1265,"width":1598,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae6d1b1a1e5b4ee290ae90bbd519dc5b","type":"text","conversion_output":true,"text":"coordinator, or another unblinded designee will perform the randomization. Random treatment","text_display":" coordinator, or another unblinded designee will perform the randomization. Random treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1850,1311],[1850,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1310,"width":1606,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cab219fa7ea746568cf77fa6c5232e9c","type":"text","conversion_output":true,"text":"assignments will be obtained using a secure Web-based randomization system. Each member","text_display":" assignments will be obtained using a secure Web-based randomization system. Each member","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1768,1354],[1768,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1525,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bffb0ae109af444f9b219f03ac2468e9","type":"text","conversion_output":true,"text":"of the study staff who has permission to randomize participants will be assigned a unique,","text_display":" of the study staff who has permission to randomize participants will be assigned a unique,","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1846,1396],[1846,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1602,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0685098553334a21bba051cb217fc06a","type":"text","conversion_output":true,"text":"nontransferable user ID that will be required to obtain random treatment allocations. The study","text_display":" nontransferable user ID that will be required to obtain random treatment allocations. The study","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1852,1439],[1852,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1608,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"802ce71ce7614143a5e7479ee6b569eb","type":"text","conversion_output":true,"text":"staff member will access the system by login on a secure (encrypted) Web site and receive the","text_display":" staff member will access the system by login on a secure (encrypted) Web site and receive the","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1772,1487],[1772,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1529,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40d6ebb203ef48c887fc47f3f0d19d27","type":"text","conversion_output":true,"text":"treatment assignment after responding to prompts confirming that the participant meets all","text_display":" treatment assignment after responding to prompts confirming that the participant meets all","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1772,1530],[1772,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":1529,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4048731a12c54028a1c9b0967cc1c235","type":"text","conversion_output":true,"text":"inclusion and exclusion criteria and has given informed consent for enrollment. 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The date of randomization will mark the start of follow-up for each participant; a","text_display":" coordinator. The date of randomization will mark the start of follow-up for each participant; a","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1790,1706],[1790,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1705,"width":1546,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83b48e7f5c6e46ee84f252d0077f5de8","type":"text","conversion_output":true,"text":"computer record is maintained for each attempt to randomize a participant. The clinical site","text_display":" computer record is maintained for each attempt to randomize a participant. 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The coordinator will also provide the name of the PT who will be contacting","text_display":" sessions will begin. The coordinator will also provide the name of the PT who will be contacting","confidence":0.99853515625,"confidence_rate":0.9999854860688677},{"cnt":[[245,1835],[1721,1835],[1721,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1477,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"848023a4bc494ee09de342a9df513405","type":"text","conversion_output":true,"text":"them. The coordinator will then alert the assigned PT who will contact the participant to","text_display":" them. 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Visits from a study PT will take place in participants'","text_display":"consecutive days, for a total of 32 visits. Visits from a study PT will take place in participants'","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1828,2105],[1828,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2105,"width":1585,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fa566dc11d2490192cf8d2e77eef552","type":"text","conversion_output":true,"text":"place of residence. The PUSH intervention group will be receiving a specific multi-component","text_display":" place of residence. 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stability and adequate nutrient intake inclusive of a healthy diet.","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7292809feb6a4169b2b0e83921aebce8","type":"page_info","conversion_output":false,"text":"CAP Protocol version 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Blinding of Study Staff","text_display":"\n\n\\subsection*{6.4 Blinding of Study Staff}","confidence":1,"confidence_rate":1},{"cnt":[[245,299],[1869,299],[1869,346],[245,346]],"region":{"top_left_x":244,"top_left_y":298,"width":1626,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d01dc1dcec5b4a9b8170bd2f3b4a981c","type":"text","conversion_output":true,"text":"Given the nature of the interventions being tested in this study, it will not be possible to blind the","text_display":"\n\nGiven the nature of the interventions being tested in this study, it will not be possible to blind the","confidence":1,"confidence_rate":1},{"cnt":[[245,344],[1704,344],[1704,389],[245,389]],"region":{"top_left_x":244,"top_left_y":343,"width":1460,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"298fd1a6fe0b407e9dfb3274947d5a32","type":"text","conversion_output":true,"text":"participants or the PTs providing the 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To minimize \"contamination\" of the","text_display":" participants or the PTs providing the interventions. 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The","text_display":" specific hypotheses or rationale of the study will not be discussed with them. 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Unblinded study staff","text_display":" assessing for treatment fidelity of PTs in both groups are unblinded. Unblinded study staff","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1384,782],[1384,829],[245,829]],"region":{"top_left_x":244,"top_left_y":782,"width":1140,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"315ab9cce3574e7bae84be133c06df8e","type":"text","conversion_output":true,"text":"involved in randomization will not perform follow-up data collection.","text_display":" involved in randomization will not perform follow-up data collection.","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1766,868],[1766,917],[245,917]],"region":{"top_left_x":244,"top_left_y":867,"width":1523,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d4b123d0ef6481d8bb13386ebf2b115","type":"text","conversion_output":true,"text":"Only those who will perform evaluations (clinical site visits and telephone interviews) after","text_display":"\n\nOnly those who will perform evaluations (clinical site visits and telephone interviews) after","confidence":1,"confidence_rate":1},{"cnt":[[245,915],[1687,915],[1687,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1443,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85216fde9cac44d788f2cad4ac4b93d2","type":"text","conversion_output":true,"text":"randomization and the Independent Safety Monitor (ISM) will be blinded to treatment","text_display":" randomization and the Independent Safety Monitor (ISM) will be blinded to treatment","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[245,958],[1854,958],[1854,1005],[245,1005]],"region":{"top_left_x":244,"top_left_y":958,"width":1611,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc89be43c2194103bcd2432c739c8a12","type":"text","conversion_output":true,"text":"assignment. Blinded study staff performing follow-up assessments or telephone interviews are","text_display":" assignment. Blinded study staff performing follow-up assessments or telephone interviews are","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1863,1001],[1863,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1619,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05a9583a79d7425e90b87e16c46d041d","type":"text","conversion_output":true,"text":"instructed not to ask about treatment assignment when in contact with participants. Participants","text_display":" instructed not to ask about treatment assignment when in contact with participants. 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In the event of inadvertent unblinding of study staff, a protocol deviation will be","text_display":" study results. In the event of inadvertent unblinding of study staff, a protocol deviation will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1824,1263],[1824,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1263,"width":1581,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfae9db433134ed48f9809bb24d44166","type":"text","conversion_output":true,"text":"reported and a notation will be made in the participant binder specifying the circumstances of","text_display":" reported and a notation will be made in the participant binder specifying the circumstances of","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1184,1311],[1184,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1310,"width":940,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb987727c39648198c247e5f89f39a90","type":"text","conversion_output":true,"text":"the unblinding event and a list of all persons unblinded.","text_display":" the unblinding event and a list of all persons unblinded.","confidence":1,"confidence_rate":1},{"cnt":[[243,1396],[1439,1396],[1439,1459],[243,1459]],"region":{"top_left_x":242,"top_left_y":1396,"width":1198,"height":63},"line":24,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"dc95d24807104b00b89f8d2572364c58","type":"section_header","conversion_output":false,"children_ids":["5f0c592fbd0e4246ba78f5842aadfbcf"],"text":"","text_display":""},{"cnt":[[247,1399],[1437,1399],[1437,1454],[247,1454]],"region":{"top_left_x":247,"top_left_y":1398,"width":1191,"height":57},"line":25,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"5f0c592fbd0e4246ba78f5842aadfbcf","type":"text","conversion_output":true,"parent_id":"dc95d24807104b00b89f8d2572364c58","text":"Section 7: Selection and Enrollment of Participants","text_display":"\n\n\\section*{Section 7: Selection and Enrollment of Participants}","confidence":1,"confidence_rate":1},{"cnt":[[271,1517],[569,1517],[569,1571],[271,1571]],"region":{"top_left_x":270,"top_left_y":1516,"width":300,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86c6ab02fcb84e0db3234aa8d33623e8","type":"section_header","conversion_output":false,"children_ids":["17cdab0dad234d8f8c7e8c3a384d57cf"],"text":"","text_display":""},{"cnt":[[275,1519],[565,1519],[565,1566],[275,1566]],"region":{"top_left_x":275,"top_left_y":1518,"width":291,"height":49},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17cdab0dad234d8f8c7e8c3a384d57cf","type":"text","conversion_output":true,"parent_id":"86c6ab02fcb84e0db3234aa8d33623e8","text":"7.1 Eligibility","text_display":"\n\n\\subsection*{7.1 Eligibility}","confidence":0.99951171875,"confidence_rate":0.9999755802732609},{"cnt":[[245,1566],[1835,1566],[1835,1613],[245,1613]],"region":{"top_left_x":244,"top_left_y":1566,"width":1591,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09bc2088fbc947edbaa36f95e3d2fed0","type":"text","conversion_output":true,"text":"Participants will be evaluated for eligibility in three phases (see Figure 2), all of which must be","text_display":"\n\nParticipants will be evaluated for eligibility in three phases (see Figure 2), all of which must be","confidence":1,"confidence_rate":1},{"cnt":[[245,1609],[1867,1609],[1867,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1609,"width":1623,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d187fa127efb4f318e614b52a73cd121","type":"text","conversion_output":true,"text":"completed no more than 26 weeks after admission to the hospital for a hip fracture. In phase 1,","text_display":" completed no more than 26 weeks after admission to the hospital for a hip fracture. In phase 1,","confidence":0.9765625,"confidence_rate":0.9997697689672589},{"cnt":[[245,1654],[1835,1654],[1835,1699],[245,1699]],"region":{"top_left_x":244,"top_left_y":1654,"width":1591,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93f3e02f42834232822c64755a806385","type":"text","conversion_output":true,"text":"patients will be assessed for inclusion criteria and medical exclusions. Information for phase 1","text_display":" patients will be assessed for inclusion criteria and medical exclusions. 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The blood collection can","text_display":" creatinine clearance ( \\(<15 ml / min\\) ), and serum albumin ( \\(<2.5 g / dl\\) ). The blood collection can","confidence":0.9377288818359375,"confidence_rate":0.9994410744283411},{"cnt":[[245,2093],[1863,2093],[1863,2140],[245,2140]],"region":{"top_left_x":244,"top_left_y":2092,"width":1619,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3f8fe4efc9f44109013a3675717183b","type":"text","conversion_output":true,"text":"occur anytime between phases 2 and 3 screening as long as it occurs after informed consent is","text_display":" occur anytime between phases 2 and 3 screening as long as it occurs after informed consent is","confidence":0.9990234375,"confidence_rate":0.9999906054321309},{"cnt":[[245,2136],[1250,2136],[1250,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2135,"width":1007,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6405273dbbea4025964ada27a9356ef9","type":"text","conversion_output":true,"text":"obtained and no more than 4 weeks prior to randomization.","text_display":" obtained and no more than 4 weeks prior to randomization.","confidence":1,"confidence_rate":1},{"cnt":[[245,2226],[1869,2226],[1869,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2225,"width":1626,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68d0093a05274b7aafa5fbc9d9f9ff3b","type":"text","conversion_output":true,"text":"Phase 3 will assess final eligibility at the clinical site center at the beginning of the baseline visit.","text_display":"\n\nPhase 3 will assess final eligibility at the clinical site center at the beginning of the baseline visit.","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[1760,2269],[1760,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2268,"width":1516,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a6ce5f3c24944deaf4537f39b1bd890","type":"text","conversion_output":true,"text":"Phase 3 must be completed no later than 26 weeks after admission to the hospital for hip","text_display":" Phase 3 must be completed no later than 26 weeks after admission to the hospital for hip","confidence":1,"confidence_rate":1},{"cnt":[[245,2312],[1828,2312],[1828,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2311,"width":1585,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbf0a07aeb734d7993bea08cbfdbf824","type":"text","conversion_output":true,"text":"fracture. Prior to the phase 3 visit, the study coordinator will attempt to contact an appropriate","text_display":" fracture. 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This final test will be used to exclude","text_display":" evaluation of ability to walk 300 meters in six minutes. This final test will be used to exclude","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1846,382],[1846,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1602,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c728a66f3c54d819fd906d7a3de2d15","type":"text","conversion_output":true,"text":"participants who are unlikely to benefit from the study interventions because their gait speed is","text_display":" participants who are unlikely to benefit from the study interventions because their gait speed is","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1876,430],[1876,475],[245,475]],"region":{"top_left_x":244,"top_left_y":429,"width":1632,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d47860de1391453e8cfa0957fc44b64a","type":"text","conversion_output":true,"text":"very low ( \\(<0.1 m / s\\) ) and to exclude those who are able to walk 300 m or more in six minutes and","text_display":" very low ( \\(<0.1 m / s\\) ) and to exclude those who are able to walk 300 m or more in six minutes and","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[245,473],[1871,473],[1871,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1628,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2dbc8e40be054c2c9e5530a4cf81453b","type":"text","conversion_output":true,"text":"are, therefore, already classified as community ambulators. 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Those individuals for whom a medical provider was not","text_display":" prior to collection of baseline data. 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Participants with complete baseline data","text_display":" testing of muscle, balance and functional performance. 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Algorithm for Screening","text_display":"\n\nFigure 2. Algorithm for Screening","confidence":1,"confidence_rate":1},{"cnt":[[271,1530],[1115,1530],[1115,1588],[271,1588]],"region":{"top_left_x":270,"top_left_y":1529,"width":846,"height":59},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae34a02d09f04d19a7bfb1cdf5c0552d","type":"section_header","conversion_output":false,"children_ids":["fdd6d2ee06e344d49f2ee55aec3e4b32"],"text":"","text_display":""},{"cnt":[[275,1534],[1111,1534],[1111,1583],[275,1583]],"region":{"top_left_x":275,"top_left_y":1533,"width":836,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdd6d2ee06e344d49f2ee55aec3e4b32","type":"text","conversion_output":true,"parent_id":"ae34a02d09f04d19a7bfb1cdf5c0552d","text":"7.2 Inclusion Criteria (Target Population)","text_display":"\n\n\\subsection*{7.2 Inclusion Criteria (Target Population)}","confidence":1,"confidence_rate":1},{"cnt":[[249,1581],[1381,1581],[1381,1629],[249,1629]],"region":{"top_left_x":249,"top_left_y":1581,"width":1133,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a6173378d644f5a86f5a568ab4a4817","type":"text","conversion_output":true,"text":"1. 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Clinical site clinician thinks participant is not a good candidate for study (e.g., not likely","confidence":0.96630859375,"confidence_rate":0.9996705154404554},{"cnt":[[404,1835],[814,1835],[814,1884],[404,1884]],"region":{"top_left_x":403,"top_left_y":1834,"width":412,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4914726b4d0545e8bf26d8e1578ac128","type":"text","conversion_output":true,"text":"to survive study period)","text_display":" to survive study period)","confidence":1,"confidence_rate":1},{"cnt":[[305,1880],[1766,1880],[1766,1927],[305,1927]],"region":{"top_left_x":305,"top_left_y":1879,"width":1462,"height":49},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a11601edfaf4357ab2edd34caffa2ad","type":"text","conversion_output":true,"text":"6.10. Development of chest pain or substantial shortness of breath or ambulating with","text_display":"\n6.10. Development of chest pain or substantial shortness of breath or ambulating with","confidence":1,"confidence_rate":1},{"cnt":[[404,1925],[1016,1925],[1016,1970],[404,1970]],"region":{"top_left_x":403,"top_left_y":1925,"width":614,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6af46d10fcf4e2d8572e554882f09e9","type":"text","conversion_output":true,"text":"severe pain during baseline SMWT","text_display":" severe pain during baseline SMWT","confidence":1,"confidence_rate":1},{"cnt":[[271,2007],[1126,2007],[1126,2067],[271,2067]],"region":{"top_left_x":270,"top_left_y":2006,"width":856,"height":61},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95fe4c04e57748fca80278e8b49fc574","type":"section_header","conversion_output":false,"children_ids":["5aae8618e1034e799b2bc2837b03b646"],"text":"","text_display":""},{"cnt":[[275,2011],[1119,2011],[1119,2065],[275,2065]],"region":{"top_left_x":275,"top_left_y":2010,"width":845,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5aae8618e1034e799b2bc2837b03b646","type":"text","conversion_output":true,"parent_id":"95fe4c04e57748fca80278e8b49fc574","text":"7.4 Identification of Hip Fracture Patients","text_display":"\n\n\\subsection*{7.4 Identification of Hip Fracture Patients}","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1807,2058],[1807,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":1563,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f44c134375441429256856dec7e84b3","type":"text","conversion_output":true,"text":"Potential participants will be identified directly from study hospitals, rehabilitation centers, or","text_display":"\n\nPotential participants will be identified directly from study hospitals, rehabilitation centers, or","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1824,2105],[1824,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2105,"width":1581,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2071c5b239e542a7a2f661afc0da8b96","type":"text","conversion_output":true,"text":"agencies that care for older adults or they may contact the study directly in response to other","text_display":" agencies that care for older adults or they may contact the study directly in response to other","confidence":1,"confidence_rate":1},{"cnt":[[245,2148],[1854,2148],[1854,2196],[245,2196]],"region":{"top_left_x":244,"top_left_y":2148,"width":1611,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"942de2e63c7a4861a32942215cf06fd9","type":"text","conversion_output":true,"text":"recruitment methods such as study recruitment flyers, advertisements, social media, or referral","text_display":" recruitment methods such as study recruitment flyers, advertisements, social media, or referral","confidence":1,"confidence_rate":1},{"cnt":[[245,2191],[1201,2191],[1201,2241],[245,2241]],"region":{"top_left_x":244,"top_left_y":2191,"width":957,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0642fb35129446ea8c8f1c3b23725fbd","type":"text","conversion_output":true,"text":"from a clinician (orthopedic surgeon, physical therapist).","text_display":" from a clinician (orthopedic surgeon, physical therapist).","confidence":1,"confidence_rate":1},{"cnt":[[245,2279],[1867,2279],[1867,2327],[245,2327]],"region":{"top_left_x":244,"top_left_y":2279,"width":1623,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83744860372847c4a1c7be012120607d","type":"text","conversion_output":true,"text":"Study hospitals will be chosen based on 1) number of hip fracture patients per hospital per year","text_display":"\n\nStudy hospitals will be chosen based on 1) number of hip fracture patients per hospital per year","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,2325],[1837,2325],[1837,2370],[245,2370]],"region":{"top_left_x":244,"top_left_y":2324,"width":1593,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eee3f3ab61f4590904d800f2e569c53","type":"text","conversion_output":true,"text":"and 2) geographic proximity between hospitals and clinical site. 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We will obtain approval of our","text_display":" other hospitals if recruitment numbers are lower than expected. We will obtain approval of our","confidence":1,"confidence_rate":1},{"cnt":[[245,2454],[1794,2454],[1794,2503],[245,2503]],"region":{"top_left_x":244,"top_left_y":2453,"width":1550,"height":50},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e43b85d733994150ae30885545da7f10","type":"text","conversion_output":true,"text":"study protocol from the UMB IRB, from each of the three clinical sites, and from each study","text_display":" study protocol from the UMB IRB, from each of the three clinical sites, and from each study","confidence":1,"confidence_rate":1},{"cnt":[[245,2585],[664,2585],[664,2625],[245,2625]],"region":{"top_left_x":244,"top_left_y":2584,"width":420,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5260190719c4d3fb4229394a2a33446","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1830,2587],[1882,2587],[1882,2625],[1830,2625]],"region":{"top_left_x":1830,"top_left_y":2586,"width":53,"height":40},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0a7ec21518e45e790e582d6edb7630d","type":"page_info","conversion_output":false,"text":"22","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-042","page":42,"lines":[{"cnt":[[245,254],[393,254],[393,296],[245,296]],"region":{"top_left_x":244,"top_left_y":253,"width":150,"height":44},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffd70fdb01274fd4802072e11dbc7fa1","type":"text","conversion_output":true,"text":"hospital.","text_display":"\nhospital.","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1721,339],[1721,387],[245,387]],"region":{"top_left_x":244,"top_left_y":339,"width":1477,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2dcd5c4c6f8f495a854185ab77867925","type":"text","conversion_output":true,"text":"Clinical site Pls will identify other method(s) of recruitment that are appropriate for their","text_display":"\nClinical site Pls will identify other method(s) of recruitment that are appropriate for their","confidence":0.9394824504852295,"confidence_rate":0.9993632014144225},{"cnt":[[245,382],[526,382],[526,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":283,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12bf27c8c7fe4d72b5622762a557a148","type":"text","conversion_output":true,"text":"respective sites.","text_display":" respective sites.","confidence":1,"confidence_rate":1},{"cnt":[[269,468],[1156,468],[1156,531],[269,531]],"region":{"top_left_x":268,"top_left_y":468,"width":888,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7439dd1ee7c42c0b2b620507a8a71e5","type":"section_header","conversion_output":false,"children_ids":["1abb51312bb347eeb86b8b4fa8fa652c"],"text":"","text_display":""},{"cnt":[[275,473],[1149,473],[1149,526],[275,526]],"region":{"top_left_x":275,"top_left_y":472,"width":875,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1abb51312bb347eeb86b8b4fa8fa652c","type":"text","conversion_output":true,"parent_id":"c7439dd1ee7c42c0b2b620507a8a71e5","text":"7.5 Participant Screening and Recruitment","text_display":"\n\n\\subsection*{7.5 Participant Screening and Recruitment}","confidence":0.9990236759185791,"confidence_rate":0.9999787654211912},{"cnt":[[245,522],[1790,522],[1790,569],[245,569]],"region":{"top_left_x":244,"top_left_y":522,"width":1546,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a272d3beb9724d3e9925c2f3ea61bda2","type":"text","conversion_output":true,"text":"Participants will be evaluated for eligibility in three phases to be completed no later than 26","text_display":"\n\nParticipants will be evaluated for eligibility in three phases to be completed no later than 26","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,567],[1841,567],[1841,612],[245,612]],"region":{"top_left_x":244,"top_left_y":567,"width":1598,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f46f953869d4368be20312272ac3d01","type":"text","conversion_output":true,"text":"weeks after admission to the hospital for hip fracture. 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A","text_display":" records and operating room logs of study hospitals to identify potential hip fracture patients. 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Patients who are provisionally","text_display":" eligibility will be obtained for patients identified at study hospitals. 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Written permission from the patient will be obtained to","text_display":" after discharge) and told about the study. Written permission from the patient will be obtained to","confidence":1,"confidence_rate":1},{"cnt":[[245,920],[1742,920],[1742,965],[245,965]],"region":{"top_left_x":244,"top_left_y":919,"width":1499,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdef9406fd584288aeb3cd04bfda246a","type":"text","conversion_output":true,"text":"allow future contact to collect additional eligibility information. Patients who are identified","text_display":" allow future contact to collect additional eligibility information. 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At any point post-admission, potential","text_display":" assessment of ability to walk 300 meters in six minutes. At any point post-admission, potential","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1798,1401],[1798,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1400,"width":1555,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"120918f1d15c43b5bdb884328bddb89e","type":"text","conversion_output":true,"text":"participants and others identified by patients (e.g., caregiver or other family member) will be","text_display":" participants and others identified by patients (e.g., caregiver or other family member) will be","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1446],[1605,1446],[1605,1493],[245,1493]],"region":{"top_left_x":244,"top_left_y":1445,"width":1361,"height":49},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74ef4486cb864bbc8d6ab765f51f1baa","type":"text","conversion_output":true,"text":"provided with additional information about what participation in the study entails.","text_display":" provided with additional information about what participation in the study entails.","confidence":1,"confidence_rate":1},{"cnt":[[269,1530],[746,1530],[746,1583],[269,1583]],"region":{"top_left_x":268,"top_left_y":1529,"width":478,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18b9d81e270d4f24ba8b317b863e6c78","type":"section_header","conversion_output":false,"children_ids":["e743eb77d3c74372b9840e278592699d"],"text":"","text_display":""},{"cnt":[[275,1534],[741,1534],[741,1579],[275,1579]],"region":{"top_left_x":275,"top_left_y":1533,"width":467,"height":47},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e743eb77d3c74372b9840e278592699d","type":"text","conversion_output":true,"parent_id":"18b9d81e270d4f24ba8b317b863e6c78","text":"7.6 Informed Consent","text_display":"\n\n\\subsection*{7.6 Informed Consent}","confidence":1,"confidence_rate":1},{"cnt":[[245,1581],[1865,1581],[1865,1626],[245,1626]],"region":{"top_left_x":244,"top_left_y":1581,"width":1621,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"461dca31c95d4a63a9fd6fe776ecef80","type":"text","conversion_output":true,"text":"Written informed consent and appropriate HIPAA authorizations and/or waivers will be obtained","text_display":"\n\nWritten informed consent and appropriate HIPAA authorizations and/or waivers will be obtained","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,1624],[1811,1624],[1811,1671],[245,1671]],"region":{"top_left_x":244,"top_left_y":1624,"width":1568,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4fb519ccd7e24b03ba3b6b0ff95c8486","type":"text","conversion_output":true,"text":"in compliance with procedures reviewed and approved by the clinical sites' IRBs prior to any","text_display":" in compliance with procedures reviewed and approved by the clinical sites' IRBs prior to any","confidence":1,"confidence_rate":1},{"cnt":[[245,1669],[1876,1669],[1876,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1669,"width":1632,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"040264c3ddff4fb6942deb80a496b23d","type":"text","conversion_output":true,"text":"data collection. Informed consent can be obtained anytime upon completion of phase 1 eligibility","text_display":" data collection. Informed consent can be obtained anytime upon completion of phase 1 eligibility","confidence":1,"confidence_rate":1},{"cnt":[[245,1712],[1869,1712],[1869,1760],[245,1760]],"region":{"top_left_x":244,"top_left_y":1712,"width":1626,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e43f0391e544e8fb3b804b27d25937a","type":"text","conversion_output":true,"text":"screening and prior to 26 weeks post hospital admission. Regardless of when informed consent","text_display":" screening and prior to 26 weeks post hospital admission. Regardless of when informed consent","confidence":1,"confidence_rate":1},{"cnt":[[245,1757],[1848,1757],[1848,1803],[245,1803]],"region":{"top_left_x":244,"top_left_y":1757,"width":1604,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7abef57f47974b99a88a07e981b5e9ae","type":"text","conversion_output":true,"text":"is obtained, study staff will follow the Good Clinical Practice guidelines for informed consent. A","text_display":" is obtained, study staff will follow the Good Clinical Practice guidelines for informed consent. A","confidence":1,"confidence_rate":1},{"cnt":[[245,1800],[1848,1800],[1848,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1800,"width":1604,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97e5aebaf9c14e68915c265562cf815d","type":"text","conversion_output":true,"text":"copy of the informed consent form (ICF) will always be provided (either in person or by mail) to","text_display":" copy of the informed consent form (ICF) will always be provided (either in person or by mail) to","confidence":0.9980475902557373,"confidence_rate":0.9999806505022475},{"cnt":[[245,1843],[1811,1843],[1811,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1843,"width":1568,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb89ca16955849f0aab8041cb98c7b63","type":"text","conversion_output":true,"text":"potential participants to allow for adequate review of the information and to allow review with","text_display":" potential participants to allow for adequate review of the information and to allow review with","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1712,1886],[1712,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1886,"width":1469,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08ce73628b4947f0b1d7828d8f2b4ff6","type":"text","conversion_output":true,"text":"family members. Prior to obtaining informed consent, time will be given to the potential","text_display":" family members. Prior to obtaining informed consent, time will be given to the potential","confidence":1,"confidence_rate":1},{"cnt":[[245,1934],[1869,1934],[1869,1979],[245,1979]],"region":{"top_left_x":244,"top_left_y":1933,"width":1626,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88223f1def844115a36e7d284be55e31","type":"text","conversion_output":true,"text":"participant to review the consent form and ask questions. If a participant has vision impairments","text_display":" participant to review the consent form and ask questions. 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The witness should also sign and personally date","text_display":" informed consent process will be witnessed. 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Even when the participant reads the consent form on their","text_display":" informed consent was freely given. Even when the participant reads the consent form on their","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1867,2196],[1867,2243],[245,2243]],"region":{"top_left_x":244,"top_left_y":2195,"width":1623,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81b36aee7c3a4b69ade84aec0a647fb8","type":"text","conversion_output":true,"text":"own, study staff will summarize all components of the ICF and remind potential participants that","text_display":" own, study staff will summarize all components of the ICF and remind potential participants that","confidence":1,"confidence_rate":1},{"cnt":[[245,2239],[1830,2239],[1830,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2238,"width":1587,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76e78963cdb843cf93624e7160d0e71f","type":"text","conversion_output":true,"text":"participation in the study is voluntary and that s/he has the right to withdraw at any time. It will","text_display":" participation in the study is voluntary and that s/he has the right to withdraw at any time. It will","confidence":0.841796875,"confidence_rate":0.998361186847626},{"cnt":[[245,2282],[1869,2282],[1869,2331],[245,2331]],"region":{"top_left_x":244,"top_left_y":2281,"width":1626,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3df2396f0bf4e07ab724ee404530376","type":"text","conversion_output":true,"text":"also be explained that signing the consent form allows the study to confirm final eligibility before","text_display":" also be explained that signing the consent form allows the study to confirm final eligibility before","confidence":1,"confidence_rate":1},{"cnt":[[245,2329],[1841,2329],[1841,2374],[245,2374]],"region":{"top_left_x":244,"top_left_y":2328,"width":1598,"height":47},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fe5f75dcf354239b1d92e0046c8831f","type":"text","conversion_output":true,"text":"randomization to a treatment group. The consent process will be performed without the use of","text_display":" randomization to a treatment group. The consent process will be performed without the use of","confidence":1,"confidence_rate":1},{"cnt":[[245,2372],[1601,2372],[1601,2419],[245,2419]],"region":{"top_left_x":244,"top_left_y":2371,"width":1357,"height":49},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5777fa6896b44c7a0d27279b0539d78","type":"text","conversion_output":true,"text":"any coercive language or behavior, and with respect for the person's autonomy.","text_display":" any coercive language or behavior, and with respect for the person's autonomy.","confidence":1,"confidence_rate":1},{"cnt":[[245,2585],[662,2585],[662,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2584,"width":418,"height":40},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f24b479c9f084214bba468a5f887743e","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1830,2587],[1882,2587],[1882,2625],[1830,2625]],"region":{"top_left_x":1830,"top_left_y":2586,"width":53,"height":40},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d017d2f9c21748c9ab495e3ad5a63431","type":"page_info","conversion_output":false,"text":"23","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-043","page":43,"lines":[{"cnt":[[245,249],[1858,249],[1858,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1615,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6dfa216127540fea7fec8a6712f0583","type":"text","conversion_output":true,"text":"The goal of the informed consent process is to increase potential participants' understanding of","text_display":"\n\nThe goal of the informed consent process is to increase potential participants' understanding of","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1803,296],[1803,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1559,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9773f08fab41425eb1a02321d01abbe6","type":"text","conversion_output":true,"text":"the study in order to better enable them to decide whether or not to enroll. Therefore, every","text_display":" the study in order to better enable them to decide whether or not to enroll. Therefore, every","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1807,339],[1807,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1563,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c086972c41e4700a0e23fcb95970cc2","type":"text","conversion_output":true,"text":"effort will be made to help potential participants understand the research project. During the","text_display":" effort will be made to help potential participants understand the research project. During the","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1740,382],[1740,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1497,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffbdac0082f948e6956a8863f98d8ec0","type":"text","conversion_output":true,"text":"informed consent process, study staff will provide participants with adequate information","text_display":" informed consent process, study staff will provide participants with adequate information","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1803,430],[1803,475],[245,475]],"region":{"top_left_x":244,"top_left_y":429,"width":1559,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1144319450b5482b9523a7594ee09473","type":"text","conversion_output":true,"text":"concerning the study procedures, respond to questions and concerns, and ensure that each","text_display":" concerning the study procedures, respond to questions and concerns, and ensure that each","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1781,473],[1781,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1538,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82772bd5c64f4711a1b975c3f7de8cdc","type":"text","conversion_output":true,"text":"individual understands all the information provided by assessing ability to provide informed","text_display":" individual understands all the information provided by assessing ability to provide informed","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[397,516],[397,556],[245,556]],"region":{"top_left_x":244,"top_left_y":515,"width":154,"height":42},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6746e336d7d4aebbcff789d252894ba","type":"text","conversion_output":true,"text":"consent.","text_display":" consent.","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1846,602],[1846,651],[245,651]],"region":{"top_left_x":244,"top_left_y":601,"width":1602,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fe05fecb6ea4d109c64c9c32a124298","type":"text","conversion_output":true,"text":"Potential participants who choose to enroll will be assessed for their ability to provide informed","text_display":"\n\nPotential participants who choose to enroll will be assessed for their ability to provide informed","confidence":1,"confidence_rate":1},{"cnt":[[245,647],[1790,647],[1790,694],[245,694]],"region":{"top_left_x":244,"top_left_y":646,"width":1546,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"115fbdb83dba48399f4eb4617aa66ed7","type":"text","conversion_output":true,"text":"consent using a local IRB-approved method, such as using the Evaluation to Sign Consent","text_display":" consent using a local IRB-approved method, such as using the Evaluation to Sign Consent","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1828,692],[1828,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1585,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75b196112c0a4ccaa222552d1ce4114d","type":"text","conversion_output":true,"text":"measure. Individuals who do not understand the study purpose, methods, risks, and benefits","text_display":" measure. Individuals who do not understand the study purpose, methods, risks, and benefits","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1850,735],[1850,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1606,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7869321f010746d98705672b51e2aeac","type":"text","conversion_output":true,"text":"are not able to provide their own informed consent and will not be eligible for participation. The","text_display":" are not able to provide their own informed consent and will not be eligible for participation. The","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1768,778],[1768,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1525,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb1b5d39bca84b9c821909be4c5e54b9","type":"text","conversion_output":true,"text":"informed consent process will be documented by including the following information in the","text_display":" informed consent process will be documented by including the following information in the","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1790,821],[1790,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1546,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bae5008825a04076bd94321813586916","type":"text","conversion_output":true,"text":"research records: that the study was explained, questions (if any) were answered, ability to","text_display":" research records: that the study was explained, questions (if any) were answered, ability to","confidence":0.99853515625,"confidence_rate":0.9999848875607663},{"cnt":[[245,868],[1843,868],[1843,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1600,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b5bc31b0e4c4c7193068c1c404627e2","type":"text","conversion_output":true,"text":"provide informed consent was assessed, subject agreed to participate and signed the consent","text_display":" provide informed consent was assessed, subject agreed to participate and signed the consent","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1833,911],[1833,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1589,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"358828e23d6745489c3d2a981840f7ae","type":"text","conversion_output":true,"text":"form and HIPAA Authorization, the presence of a witness for individuals with hearing or vision","text_display":" form and HIPAA Authorization, the presence of a witness for individuals with hearing or vision","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1790,954],[1790,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1546,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11956671a40a49a8b9d4fa697ef6de9a","type":"text","conversion_output":true,"text":"impairments, and a copy of the signed consent form and HIPAA Authorization was given to","text_display":" impairments, and a copy of the signed consent form and HIPAA Authorization was given to","confidence":1,"confidence_rate":1},{"cnt":[[245,999],[1751,999],[1751,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":999,"width":1507,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9719f561c3e9438b911a13fdebbb9f71","type":"text","conversion_output":true,"text":"participant and, if necessary, left in the chart of facility. For people who provide informed","text_display":" participant and, if necessary, left in the chart of facility. 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If the person provided consent while in a medical facility, a","text_display":" ICF will be given to the participant. If the person provided consent while in a medical facility, a","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1794,1130],[1794,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1550,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c75783a17a74bb69d22fac787d6cbf6","type":"text","conversion_output":true,"text":"copy of the ICF will go into her/his chart. The clinical site PI and/or designee will ensure the","text_display":" copy of the ICF will go into her/his chart. 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Efforts}","confidence":1,"confidence_rate":1},{"cnt":[[245,1609],[1850,1609],[1850,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1609,"width":1606,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5005dbdc8bb4c5cb75a38c0ebb6369f","type":"text","conversion_output":true,"text":"At the time of randomization, participants will receive written instructions about the schedule of","text_display":"\n\nAt the time of randomization, participants will receive written instructions about the schedule of","confidence":1,"confidence_rate":1},{"cnt":[[245,1654],[1755,1654],[1755,1699],[245,1699]],"region":{"top_left_x":244,"top_left_y":1654,"width":1512,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91896cc683d948f3ae02332a3b35fa0f","type":"text","conversion_output":true,"text":"follow-up assessments, PT intervention visits, dietician contact, and four-week telephone","text_display":" follow-up assessments, PT intervention visits, dietician contact, and four-week telephone","confidence":1,"confidence_rate":1},{"cnt":[[245,1697],[1809,1697],[1809,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1697,"width":1565,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"343a619311a44c21a5f2450d87e34439","type":"text","conversion_output":true,"text":"interviews. To maintain rapport, the same staff member will, whenever possible, contact and","text_display":" interviews. To maintain rapport, the same staff member will, whenever possible, contact and","confidence":1,"confidence_rate":1},{"cnt":[[245,1740],[1841,1740],[1841,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1740,"width":1598,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eafb252892bd4d2b88fd0afdcfed1155","type":"text","conversion_output":true,"text":"visit the participant throughout the study. Minimizing waiting time, providing free transportation","text_display":" visit the participant throughout the study. Minimizing waiting time, providing free transportation","confidence":1,"confidence_rate":1},{"cnt":[[245,1783],[1803,1783],[1803,1833],[245,1833]],"region":{"top_left_x":244,"top_left_y":1783,"width":1559,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01ba59511c794c84b685e3d76148aa5b","type":"text","conversion_output":true,"text":"for the baseline and follow-up assessment, and providing comfortable waiting room facilities","text_display":" for the baseline and follow-up assessment, and providing comfortable waiting room facilities","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[1656,1830],[1656,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1830,"width":1413,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41a2c33000264e31ad557a19263f009c","type":"text","conversion_output":true,"text":"make the visits more pleasant, thereby enhancing participant retention at follow-up.","text_display":" make the visits more pleasant, thereby enhancing participant retention at follow-up.","confidence":1,"confidence_rate":1},{"cnt":[[245,1916],[1869,1916],[1869,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1916,"width":1626,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40f4cef2bd254966a7f35e7ec208b3b4","type":"text","conversion_output":true,"text":"Participants will be interviewed by telephone every four weeks after randomization for 16 weeks","text_display":"\n\nParticipants will be interviewed by telephone every four weeks after randomization for 16 weeks","confidence":1,"confidence_rate":1},{"cnt":[[245,1962],[1858,1962],[1858,2009],[245,2009]],"region":{"top_left_x":244,"top_left_y":1961,"width":1615,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77f286e9e9e944d4b31d30bdcc42e180","type":"text","conversion_output":true,"text":"to collect information on expected AEs and RAEs. These regular phone contacts also help with","text_display":" to collect information on expected AEs and RAEs. These regular phone contacts also help with","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1760,2007],[1760,2052],[245,2052]],"region":{"top_left_x":244,"top_left_y":2006,"width":1516,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4baffff037d94f5482148871c35f0acf","type":"text","conversion_output":true,"text":"retention. Participants will be reminded of the next phone call and follow-up assessment.","text_display":" retention. Participants will be reminded of the next phone call and follow-up assessment.","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1781,2093],[1781,2140],[245,2140]],"region":{"top_left_x":244,"top_left_y":2092,"width":1538,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09f227f09fc148ec9c28315529b64327","type":"text","conversion_output":true,"text":"If participants are unable to come to the clinical site for the follow-up assessment, a visit at","text_display":"\n\nIf participants are unable to come to the clinical site for the follow-up assessment, a visit at","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[1762,2136],[1762,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2135,"width":1518,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe2035c0fada47f59bae5b80b812f9d2","type":"text","conversion_output":true,"text":"another location (home or another facility) will be scheduled. Telephone interviews will be","text_display":" another location (home or another facility) will be scheduled. Telephone interviews will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2179],[1098,2179],[1098,2228],[245,2228]],"region":{"top_left_x":244,"top_left_y":2178,"width":854,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da237d72e0e04161868dd9abdc12721d","type":"text","conversion_output":true,"text":"scheduled if in-person visits cannot be completed.","text_display":" scheduled if in-person visits cannot be completed.","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[1794,2269],[1794,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2268,"width":1550,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9844250ea3764d96bf347e0cb7ff7859","type":"text","conversion_output":true,"text":"Clinical sites will keep detailed records of rescheduled and missed study assessment visits,","text_display":"\n\nClinical sites will keep detailed records of rescheduled and missed study assessment visits,","confidence":1,"confidence_rate":1},{"cnt":[[245,2312],[1861,2312],[1861,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2311,"width":1617,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72cde698efb746b3873caa5054a99f91","type":"text","conversion_output":true,"text":"missed phone interviews, and missed intervention visits. Participant retention will be monitored,","text_display":" missed phone interviews, and missed intervention visits. Participant retention will be monitored,","confidence":1,"confidence_rate":1},{"cnt":[[245,2355],[1876,2355],[1876,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2354,"width":1632,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29747576180f400ab1bcd84f552c963a","type":"text","conversion_output":true,"text":"and efforts will be made to provide support and encouragement to participants who are at risk of","text_display":" and efforts will be made to provide support and encouragement to participants who are at risk of","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[634,2402],[634,2447],[245,2447]],"region":{"top_left_x":244,"top_left_y":2401,"width":390,"height":47},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb1c52499127481fa87073cf5ab07f05","type":"text","conversion_output":true,"text":"being lost to follow-up.","text_display":" being lost to follow-up.","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[662,2587],[662,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":418,"height":38},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"083d0a89c79b4d8582a154def24701a7","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1830,2587],[1882,2587],[1882,2625],[1830,2625]],"region":{"top_left_x":1830,"top_left_y":2586,"width":53,"height":40},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12c5d29e3e824944a6d1a927174b6102","type":"page_info","conversion_output":false,"text":"24","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-044","page":44,"lines":[{"cnt":[[271,245],[935,245],[935,305],[271,305]],"region":{"top_left_x":270,"top_left_y":244,"width":665,"height":62},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d767f748c7204f89ad9c32478ffaaa9d","type":"section_header","conversion_output":false,"children_ids":["1aa54ff4ee744b0a912409e196c0c14b"],"text":"","text_display":""},{"cnt":[[275,249],[930,249],[930,301],[275,301]],"region":{"top_left_x":275,"top_left_y":249,"width":656,"height":52},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1aa54ff4ee744b0a912409e196c0c14b","type":"text","conversion_output":true,"parent_id":"d767f748c7204f89ad9c32478ffaaa9d","text":"8.2 Drop-out Prevention Efforts","text_display":"\n\n\\subsection*{8.2 Drop-out Prevention Efforts}","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1740,296],[1740,346],[245,346]],"region":{"top_left_x":244,"top_left_y":296,"width":1497,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46a917be8aef42489e8e6f9e0d3c3c6a","type":"text","conversion_output":true,"text":"The following procedures will be implemented to minimize and monitor missed follow-up","text_display":"\n\nThe following procedures will be implemented to minimize and monitor missed follow-up","confidence":1,"confidence_rate":1},{"cnt":[[245,344],[1246,344],[1246,389],[245,389]],"region":{"top_left_x":244,"top_left_y":343,"width":1003,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55f3f238b5bc47eda0f18acec77db2b6","type":"text","conversion_output":true,"text":"assessments, telephone interviews, and intervention visits:","text_display":" assessments, telephone interviews, and intervention visits:","confidence":1,"confidence_rate":1},{"cnt":[[305,387],[1878,387],[1878,436],[305,436]],"region":{"top_left_x":305,"top_left_y":386,"width":1573,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7616f45e27994ba09a3c30252a1008ae","type":"text","conversion_output":true,"text":"- Providing pre-visit reminders (e.g., postcards and phone calls) for upcoming assessment","text_display":"\n- Providing pre-visit reminders (e.g., postcards and phone calls) for upcoming assessment","confidence":1,"confidence_rate":1},{"cnt":[[367,434],[1869,434],[1869,483],[367,483]],"region":{"top_left_x":367,"top_left_y":433,"width":1503,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99b045c4fec54dd89691dd420f3c5f3b","type":"text","conversion_output":true,"text":"visits. Also, reminders about the upcoming follow-up assessment will be provided during","text_display":" visits. 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Also, considerable effort will be expended to","text_display":" or she is welcome to rejoin the study at any time. 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The CCC will track","text_display":" activity of study staff members, form completion, and form submission. The CCC will track","confidence":1,"confidence_rate":1},{"cnt":[[245,1418],[1781,1418],[1781,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1417,"width":1538,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec1bd9eb159e48cbb30b5a2aa9beb44d","type":"text","conversion_output":true,"text":"screening and recruitment yields against the number expected per site. The CCC will work","text_display":" screening and recruitment yields against the number expected per site. The CCC will work","confidence":1,"confidence_rate":1},{"cnt":[[245,1461],[1800,1461],[1800,1508],[245,1508]],"region":{"top_left_x":244,"top_left_y":1460,"width":1557,"height":49},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c726c60195b549e68a70cf7b1f5537de","type":"text","conversion_output":true,"text":"closely with clinical site PIs and the Recruitment and Evaluation SOC to identify and reduce","text_display":" closely with clinical site PIs and the Recruitment and Evaluation SOC to identify and reduce","confidence":0.66552734375,"confidence_rate":0.9958111118412566},{"cnt":[[245,1504],[1878,1504],[1878,1553],[245,1553]],"region":{"top_left_x":244,"top_left_y":1503,"width":1634,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"798ac07eb4084fb0b2de4558f097dcef","type":"text","conversion_output":true,"text":"barriers to recruitment. We will review the number of patients screened relative to the number of","text_display":" barriers to recruitment. 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Additionally, a study management database","text_display":" are eligible, and the percent who are randomized. 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Retention will be monitored through completion","text_display":" member to identify possible areas for retraining. Retention will be monitored through completion","confidence":1,"confidence_rate":1},{"cnt":[[245,2118],[1772,2118],[1772,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2118,"width":1529,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aef478b902ea4c1c93fc6b888bbff9ad","type":"text","conversion_output":true,"text":"rates of follow-up assessment visits, intervention visits, and telephone interviews. Regular","text_display":" rates of follow-up assessment visits, intervention visits, and telephone interviews. 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Members of the CCC maintain regular","confidence":1,"confidence_rate":1},{"cnt":[[245,2206],[806,2206],[806,2254],[245,2254]],"region":{"top_left_x":244,"top_left_y":2206,"width":562,"height":48},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e1b3ef876cb456da2c6e0e52d423832","type":"text","conversion_output":true,"text":"phone contact with clinic staff to:","text_display":" phone contact with clinic staff to:","confidence":1,"confidence_rate":1},{"cnt":[[434,2252],[1399,2252],[1399,2299],[434,2299]],"region":{"top_left_x":433,"top_left_y":2251,"width":966,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38c1f9b51e8d467199442f01e34e433b","type":"text","conversion_output":true,"text":"1. Review recruitment goals and yields for clinical sites,","text_display":"\n1. Review recruitment goals and yields for clinical sites,","confidence":1,"confidence_rate":1},{"cnt":[[432,2295],[1854,2295],[1854,2344],[432,2344]],"region":{"top_left_x":431,"top_left_y":2294,"width":1424,"height":50},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d37a2aa495943ce9157e3d69a3d152d","type":"text","conversion_output":true,"text":"2. Review the recruitment plan and progress in achieving the objectives outlined in","text_display":"\n2. Review the recruitment plan and progress in achieving the objectives outlined in","confidence":1,"confidence_rate":1},{"cnt":[[494,2338],[655,2338],[655,2387],[494,2387]],"region":{"top_left_x":494,"top_left_y":2337,"width":162,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5315ca0f8af140c9bb5d2d9300711f98","type":"text","conversion_output":true,"text":"the plan,","text_display":" the plan,","confidence":1,"confidence_rate":1},{"cnt":[[432,2383],[1549,2383],[1549,2430],[432,2430]],"region":{"top_left_x":431,"top_left_y":2382,"width":1119,"height":48},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86b2b56f1fc642a393edb71c7130b53c","type":"text","conversion_output":true,"text":"3. Share successful and unsuccessful recruitment methods, and","text_display":"\n3. Share successful and unsuccessful recruitment methods, and","confidence":1,"confidence_rate":1},{"cnt":[[430,2428],[801,2428],[801,2471],[430,2471]],"region":{"top_left_x":429,"top_left_y":2427,"width":373,"height":44},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07a61c3333bd4f878c56272ba8403f39","type":"text","conversion_output":true,"text":"4. Review retention.","text_display":"\n4. Review retention.","confidence":1,"confidence_rate":1},{"cnt":[[245,2585],[664,2585],[664,2625],[245,2625]],"region":{"top_left_x":244,"top_left_y":2584,"width":420,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d522e812b2b47db90e0877ff7c8df63","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1830,2587],[1882,2587],[1882,2625],[1830,2625]],"region":{"top_left_x":1830,"top_left_y":2586,"width":53,"height":40},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10d311f42f0b4aa6971684433a9b97e4","type":"page_info","conversion_output":false,"text":"25","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-045","page":45,"lines":[{"cnt":[[247,296],[1751,296],[1751,342],[247,342]],"region":{"top_left_x":247,"top_left_y":296,"width":1504,"height":46},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b101057b57b48af8bb51f840279b441","type":"text","conversion_output":true,"text":"If clinical sites encounter difficulties in recruitment or retention, the CCC (or a subgroup it","text_display":"\n\nIf clinical sites encounter difficulties in recruitment or retention, the CCC (or a subgroup it","confidence":1,"confidence_rate":1},{"cnt":[[247,339],[1848,339],[1848,385],[247,385]],"region":{"top_left_x":247,"top_left_y":339,"width":1601,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cca190ca55647d7a08a1a5049a29211","type":"text","conversion_output":true,"text":"designates) will provide a graduated set of assistance responses that are based on the degree","text_display":" designates) will provide a graduated set of assistance responses that are based on the degree","confidence":1,"confidence_rate":1},{"cnt":[[247,385],[1837,385],[1837,430],[247,430]],"region":{"top_left_x":247,"top_left_y":384,"width":1590,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"872cfd810db44fd684ed402d0eed6938","type":"text","conversion_output":true,"text":"of recruitment or retention shortfall. Solutions will be developed that are based on site-specific","text_display":" of recruitment or retention shortfall. Solutions will be developed that are based on site-specific","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,430],[372,430],[372,466],[245,466]],"region":{"top_left_x":244,"top_left_y":429,"width":128,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d0ba4780fdb49ad9494a139e6847134","type":"text","conversion_output":true,"text":"issues.","text_display":" issues.","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[958,559],[958,621],[245,621]],"region":{"top_left_x":244,"top_left_y":558,"width":715,"height":63},"line":5,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"7aa432f3cc414eb3a7a2e76490ca14a5","type":"section_header","conversion_output":false,"children_ids":["50cc2f3499a4409aa36ea481368bf7d2"],"text":"","text_display":""},{"cnt":[[249,563],[956,563],[956,617],[249,617]],"region":{"top_left_x":249,"top_left_y":562,"width":708,"height":55},"line":6,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"50cc2f3499a4409aa36ea481368bf7d2","type":"text","conversion_output":true,"parent_id":"7aa432f3cc414eb3a7a2e76490ca14a5","text":"Section 9: Study Interventions","text_display":"\n\n\\section*{Section 9: Study Interventions}","confidence":1,"confidence_rate":1},{"cnt":[[271,683],[569,683],[569,728],[271,728]],"region":{"top_left_x":270,"top_left_y":683,"width":300,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d793836e0b04e5ca3ab9c48ede4f2e0","type":"section_header","conversion_output":false,"children_ids":["dca864b655b94dfabacc05a1a6072c66"],"text":"","text_display":""},{"cnt":[[275,683],[565,683],[565,724],[275,724]],"region":{"top_left_x":275,"top_left_y":683,"width":291,"height":42},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dca864b655b94dfabacc05a1a6072c66","type":"text","conversion_output":true,"parent_id":"2d793836e0b04e5ca3ab9c48ede4f2e0","text":"9.1 Overview","text_display":"\n\n\\subsection*{9.1 Overview}","confidence":1,"confidence_rate":1},{"cnt":[[247,730],[1863,730],[1863,776],[247,776]],"region":{"top_left_x":247,"top_left_y":730,"width":1616,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9da068f3b3f491bb087be536074da1b","type":"text","conversion_output":true,"text":"Participants will be assigned to one of two treatment groups: 1) PUSH or 2) PULSE. The PUSH","text_display":"\n\nParticipants will be assigned to one of two treatment groups: 1) PUSH or 2) PULSE. The PUSH","confidence":1,"confidence_rate":1},{"cnt":[[247,778],[1837,778],[1837,821],[247,821]],"region":{"top_left_x":247,"top_left_y":777,"width":1590,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b1c700060874c37aa779b5f42866d95","type":"text","conversion_output":true,"text":"intervention group will receive a specific multi-component training intervention and the PULSE","text_display":" intervention group will receive a specific multi-component training intervention and the PULSE","confidence":1,"confidence_rate":1},{"cnt":[[247,821],[1766,821],[1766,866],[247,866]],"region":{"top_left_x":247,"top_left_y":820,"width":1520,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9821a4f75fde47f4bb3f73aa2f297894","type":"text","conversion_output":true,"text":"intervention group will receive a non-specific intervention that stimulates the same muscle","text_display":" intervention group will receive a non-specific intervention that stimulates the same muscle","confidence":1,"confidence_rate":1},{"cnt":[[247,864],[1871,864],[1871,909],[247,909]],"region":{"top_left_x":247,"top_left_y":863,"width":1625,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78124d71f4aa41fa8eb77c1b165371e2","type":"text","conversion_output":true,"text":"groups as the PUSH intervention. Both groups will receive 32 visits of approximately 60 minutes","text_display":" groups as the PUSH intervention. Both groups will receive 32 visits of approximately 60 minutes","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,907],[1873,907],[1873,952],[245,952]],"region":{"top_left_x":244,"top_left_y":906,"width":1630,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"761e2fcfb1df418ca16c742396d69ff7","type":"text","conversion_output":true,"text":"duration from a study PT. Participants will receive two visits per week, on non-consecutive days,","text_display":" duration from a study PT. Participants will receive two visits per week, on non-consecutive days,","confidence":1,"confidence_rate":1},{"cnt":[[245,952],[1807,952],[1807,999],[245,999]],"region":{"top_left_x":244,"top_left_y":951,"width":1563,"height":49},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb837c3bb1094e9bb0b63549a54be4c2","type":"text","conversion_output":true,"text":"for 16 weeks. Missed visits can be replaced during subsequent weeks if there is at least one","text_display":" for 16 weeks. Missed visits can be replaced during subsequent weeks if there is at least one","confidence":1,"confidence_rate":1},{"cnt":[[245,1041],[245,993],[1777,995],[1777,1043]],"region":{"top_left_x":244,"top_left_y":992,"width":1533,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7d3fe9d36994ceeb5d0c8a7ec5ee981","type":"text","conversion_output":true,"text":"day in between visits and no more than three visits in the week. Visits will take place in the","text_display":" day in between visits and no more than three visits in the week. Visits will take place in the","confidence":1,"confidence_rate":1},{"cnt":[[247,1040],[784,1040],[784,1085],[247,1085]],"region":{"top_left_x":247,"top_left_y":1039,"width":538,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96b7e34afaeb410dad6699a882829c63","type":"text","conversion_output":true,"text":"participant's place of residence.","text_display":" participant's place of residence.","confidence":0.998046875,"confidence_rate":0.9999485530382876},{"cnt":[[271,1130],[838,1130],[838,1175],[271,1175]],"region":{"top_left_x":270,"top_left_y":1130,"width":568,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f938048d113146a89fa0a9c9864b6135","type":"section_header","conversion_output":false,"children_ids":["adb111e63f054947880277108cdcb445"],"text":"","text_display":""},{"cnt":[[277,1134],[836,1134],[836,1173],[277,1173]],"region":{"top_left_x":277,"top_left_y":1134,"width":559,"height":40},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"adb111e63f054947880277108cdcb445","type":"text","conversion_output":true,"parent_id":"f938048d113146a89fa0a9c9864b6135","text":"9.2 Nutritional Intervention","text_display":"\n\n\\subsection*{9.2 Nutritional Intervention}","confidence":1,"confidence_rate":1},{"cnt":[[247,1177],[1803,1177],[1803,1222],[247,1222]],"region":{"top_left_x":247,"top_left_y":1177,"width":1556,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3a2461f36394cdd9eba7f8c76bd2330","type":"text","conversion_output":true,"text":"Given the importance of ensuring adequate nutrition in both study groups, we will provide all","text_display":"\n\nGiven the importance of ensuring adequate nutrition in both study groups, we will provide all","confidence":1,"confidence_rate":1},{"cnt":[[247,1225],[1772,1225],[1772,1268],[247,1268]],"region":{"top_left_x":247,"top_left_y":1224,"width":1526,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df36ee9a45c7493db05f363c7b663399","type":"text","conversion_output":true,"text":"participants with 2000 IU of vitamin D3, 600 mg of calcium, and a multivitamin daily for the","text_display":" participants with 2000 IU of vitamin D3, 600 mg of calcium, and a multivitamin daily for the","confidence":0.97119140625,"confidence_rate":0.9997216415364754},{"cnt":[[247,1268],[1807,1268],[1807,1313],[247,1313]],"region":{"top_left_x":247,"top_left_y":1267,"width":1560,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4362303c6534b1cb168bf7996165ec4","type":"text","conversion_output":true,"text":"duration of the 16-week study and nutritional counseling to ensure weight stability, adequate","text_display":" duration of the 16-week study and nutritional counseling to ensure weight stability, adequate","confidence":0.54638671875,"confidence_rate":0.9938513453332077},{"cnt":[[247,1311],[1858,1311],[1858,1356],[247,1356]],"region":{"top_left_x":247,"top_left_y":1310,"width":1612,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cafb0d5859f3413fa8cb3fa8e6e9a385","type":"text","conversion_output":true,"text":"nutrient intake of 1 g protein/kg body weight inclusive of a healthy diet (50\\% carbohydrate, 20\\%","text_display":" nutrient intake of 1 g protein/kg body weight inclusive of a healthy diet (50\\% carbohydrate, 20\\%","confidence":0.747172610745891,"confidence_rate":0.9972541630593762},{"cnt":[[247,1354],[1704,1354],[1704,1399],[247,1399]],"region":{"top_left_x":247,"top_left_y":1353,"width":1457,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97eb42cf6ea244d2af658fe4bbbfbca3","type":"text","conversion_output":true,"text":"protein, \\(30 \\%\\) fat). Participants will be screened at the time of randomization to assess","text_display":" protein, \\(30 \\%\\) fat). Participants will be screened at the time of randomization to assess","confidence":0.9873406740371138,"confidence_rate":0.999865902276417},{"cnt":[[247,1396],[1876,1396],[1876,1446],[247,1446]],"region":{"top_left_x":247,"top_left_y":1396,"width":1629,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a257dab2c3e54310a91aa8b9e4b6bacd","type":"text","conversion_output":true,"text":"nutritional risk using the Mini Nutritional Assessment-Short Form (MNA®-SF). \\({ }^{6}\\) Those who score","text_display":" nutritional risk using the Mini Nutritional Assessment-Short Form (MNA®-SF). \\({ }^{6}\\) Those who score","confidence":0.9960987542294788,"confidence_rate":0.9999641394000723},{"cnt":[[247,1444],[1824,1444],[1824,1489],[247,1489]],"region":{"top_left_x":247,"top_left_y":1443,"width":1578,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af3cfd4e3bc24ea3a375497737a684d6","type":"text","conversion_output":true,"text":"\\(\\leq 7\\) (malnourished) at baseline and participants with serum albumin \\(2.5-3.5 g / dl\\) (regardless of","text_display":" \\(\\leq 7\\) (malnourished) at baseline and participants with serum albumin \\(2.5-3.5 g / dl\\) (regardless of","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1781,1487],[1781,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1538,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08c23a8a881c409f9d10cd2e3779981b","type":"text","conversion_output":true,"text":"the score on MNA®-SF) will receive a visit from a registered dietician (RD) in their place of","text_display":" the score on MNA®-SF) will receive a visit from a registered dietician (RD) in their place of","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[247,1530],[1760,1530],[1760,1575],[247,1575]],"region":{"top_left_x":247,"top_left_y":1529,"width":1513,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e32508cbdf2b420abcae98fdf338c389","type":"text","conversion_output":true,"text":"residence within seven days of randomization. The RD will evaluate and counsel them on","text_display":" residence within seven days of randomization. The RD will evaluate and counsel them on","confidence":1,"confidence_rate":1},{"cnt":[[247,1575],[1854,1575],[1854,1620],[247,1620]],"region":{"top_left_x":247,"top_left_y":1574,"width":1608,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5de54cee0f614e158137d05f6229235d","type":"text","conversion_output":true,"text":"making dietary modifications based on their protein, caloric and other dietary deficiencies using","text_display":" making dietary modifications based on their protein, caloric and other dietary deficiencies using","confidence":1,"confidence_rate":1},{"cnt":[[247,1618],[1848,1618],[1848,1663],[247,1663]],"region":{"top_left_x":247,"top_left_y":1617,"width":1601,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6df05a6c81e54fd09ca4af200d4e16bb","type":"text","conversion_output":true,"text":"a standardized approach across the three study sites. \\({ }^{7-9}\\) The RD will follow up with participants","text_display":" a standardized approach across the three study sites. \\({ }^{7-9}\\) The RD will follow up with participants","confidence":1,"confidence_rate":1},{"cnt":[[247,1663],[1687,1663],[1687,1708],[247,1708]],"region":{"top_left_x":247,"top_left_y":1662,"width":1440,"height":47},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a284a7b0eb3b4f698c9cd3a7ea84895f","type":"text","conversion_output":true,"text":"by telephone one week after the visit to assess understanding and implementation of","text_display":" by telephone one week after the visit to assess understanding and implementation of","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1800,1706],[1800,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1705,"width":1557,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63f13bd1bd6f4364969e93b70768aa83","type":"text","conversion_output":true,"text":"recommendations. Participants who score 8-11 (at risk of malnutrition) at baseline and have","text_display":" recommendations. Participants who score 8-11 (at risk of malnutrition) at baseline and have","confidence":0.9145922660827637,"confidence_rate":0.9990704643293199},{"cnt":[[247,1749],[1815,1749],[1815,1794],[247,1794]],"region":{"top_left_x":247,"top_left_y":1748,"width":1569,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b1cb2fa53d640d2bf48b9bf24f4e6be","type":"text","conversion_output":true,"text":"serum albumin level \\(>3.5 g / dl\\) will receive a telephone dietary consultation with the RD within","text_display":" serum albumin level \\(>3.5 g / dl\\) will receive a telephone dietary consultation with the RD within","confidence":0.998046875,"confidence_rate":0.9999817288133145},{"cnt":[[245,1792],[1841,1792],[1841,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1598,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e978a503361a45679b9751fc41134f3c","type":"text","conversion_output":true,"text":"seven days of randomization. Based on the participant's eating habits and food intake, the RD","text_display":" seven days of randomization. Based on the participant's eating habits and food intake, the RD","confidence":1,"confidence_rate":1},{"cnt":[[245,1839],[1867,1839],[1867,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1839,"width":1623,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8b1cb871f044af59847cecd7853b3e4","type":"text","conversion_output":true,"text":"may make the clinical determination that an in-person consultation is warranted. In these cases,","text_display":" may make the clinical determination that an in-person consultation is warranted. In these cases,","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1800,1882],[1800,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1882,"width":1557,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78ab1adbd48e465fb9fb542ee03a370b","type":"text","conversion_output":true,"text":"the RD will schedule an in-person dietary consultation, following the same protocol as those","text_display":" the RD will schedule an in-person dietary consultation, following the same protocol as those","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1846,1925],[1846,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1602,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"132a9abfb77648308a6108daa1878207","type":"text","conversion_output":true,"text":"who score in the malnourished range. Those with a score \\(\\geq 12\\) on the MNA®-SF and who have","text_display":" who score in the malnourished range. Those with a score \\(\\geq 12\\) on the MNA®-SF and who have","confidence":0.9960966110229492,"confidence_rate":0.9999588321412868},{"cnt":[[245,1968],[1852,1968],[1852,2015],[245,2015]],"region":{"top_left_x":244,"top_left_y":1967,"width":1608,"height":49},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b30e612563747e7a28a7a3d122368d9","type":"text","conversion_output":true,"text":"serum albumin level \\(>3.5 g / dl\\) at baseline will receive brief telephone contact within seven days","text_display":" serum albumin level \\(>3.5 g / dl\\) at baseline will receive brief telephone contact within seven days","confidence":0.6847240924835205,"confidence_rate":0.996531357151665},{"cnt":[[245,2013],[1687,2013],[1687,2060],[245,2060]],"region":{"top_left_x":244,"top_left_y":2013,"width":1443,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19bd48d55b6949bea77e905463249966","type":"text","conversion_output":true,"text":"of randomization from the RD to discuss the importance of calorie and protein intake.","text_display":" of randomization from the RD to discuss the importance of calorie and protein intake.","confidence":1,"confidence_rate":1},{"cnt":[[245,2101],[1798,2101],[1798,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2101,"width":1555,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb3783c2de3047efb39cf9e278c67346","type":"text","conversion_output":true,"text":"Weight will be monitored during home PT visits every four weeks and those who lose \\(2 \\%\\) or","text_display":"\n\nWeight will be monitored during home PT visits every four weeks and those who lose \\(2 \\%\\) or","confidence":0.7790236473083496,"confidence_rate":0.9974021939285315},{"cnt":[[245,2144],[1869,2144],[1869,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2144,"width":1626,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85cf323329304734ab3d6938ef583f88","type":"text","conversion_output":true,"text":"more body weight in a four-week period will receive another telephone consultation by the study","text_display":" more body weight in a four-week period will receive another telephone consultation by the study","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[247,2189],[1749,2189],[1749,2237],[247,2237]],"region":{"top_left_x":247,"top_left_y":2189,"width":1502,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32667b1ee86247f681fa2782291d90de","type":"text","conversion_output":true,"text":"RD. This protocol applies to anyone who loses \\(2 \\%\\) or more of body weight, regardless of","text_display":" RD. This protocol applies to anyone who loses \\(2 \\%\\) or more of body weight, regardless of","confidence":0.9873332977294922,"confidence_rate":0.9998643963345496},{"cnt":[[245,2234],[1824,2234],[1824,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2234,"width":1581,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ddd3f9ad39b4958a31d847a662b1cde","type":"text","conversion_output":true,"text":"whether the participant is trying to lose weight. In the event that a weight measurement is not","text_display":" whether the participant is trying to lose weight. In the event that a weight measurement is not","confidence":1,"confidence_rate":1},{"cnt":[[245,2277],[1880,2277],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2277,"width":1636,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b743c718f3d4c7d98a8c3bc9984780c","type":"text","conversion_output":true,"text":"obtained at the last PT visit, the participant's weight at the 16 -week follow-up assessment will be","text_display":" obtained at the last PT visit, the participant's weight at the 16 -week follow-up assessment will be","confidence":0.9970715045928955,"confidence_rate":0.9999728448887077},{"cnt":[[245,2320],[1811,2320],[1811,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2320,"width":1568,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"295d6ab9f66e482f987f55fa8818cb23","type":"text","conversion_output":true,"text":"compared to his or her baseline weight and, if there is weight loss of \\(5 \\%\\) or more, the clinical","text_display":" compared to his or her baseline weight and, if there is weight loss of \\(5 \\%\\) or more, the clinical","confidence":0.9990234375,"confidence_rate":0.9999905142231666},{"cnt":[[245,2363],[1749,2363],[1749,2411],[245,2411]],"region":{"top_left_x":244,"top_left_y":2363,"width":1505,"height":48},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b40a72fba9241758ccad7eaa5c74914","type":"text","conversion_output":true,"text":"site PI or clinical site clinician will review the participant's weight trajectory, baseline BMI,","text_display":" site PI or clinical site clinician will review the participant's weight trajectory, baseline BMI,","confidence":0.58125901222229,"confidence_rate":0.9946949178246711},{"cnt":[[245,2408],[1852,2408],[1852,2456],[245,2456]],"region":{"top_left_x":244,"top_left_y":2408,"width":1608,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22359b17b0a744c788ce7931937ab503","type":"text","conversion_output":true,"text":"baseline MNA®-SF score, and registered dietician's documentation and, if warranted based on","text_display":" baseline MNA®-SF score, and registered dietician's documentation and, if warranted based on","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[249,2587],[660,2587],[660,2623],[249,2623]],"region":{"top_left_x":249,"top_left_y":2586,"width":411,"height":38},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dca7e3427f64f2687c5e871f899f5e3","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b657227e94844ef1a6ee813585766ce9","type":"page_info","conversion_output":false,"text":"26","text_display":"","confidence":0.99853515625,"confidence_rate":0.9992673097074676}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-046","page":46,"lines":[{"cnt":[[245,249],[1777,249],[1777,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1533,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f8cc8ee1cd34169823b61e15d77d2b7","type":"text","conversion_output":true,"text":"clinical judgment, will refer the participant to a dietician or medical provider for follow-up of","text_display":"\nclinical judgment, will refer the participant to a dietician or medical provider for follow-up of","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[780,296],[780,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":536,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c80e6b5a67d40819235738cf777b5a1","type":"text","conversion_output":true,"text":"possible poor nutritional status.","text_display":" possible poor nutritional status.","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1828,339],[1828,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1585,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f71bbacd07d247ce9c97b4c266f3fd1c","type":"text","conversion_output":true,"text":"Participants randomized prior to version 10.0 of the protocol received vitamin D, calcium, and","text_display":"\nParticipants randomized prior to version 10.0 of the protocol received vitamin D, calcium, and","confidence":0.9946331977844238,"confidence_rate":0.9999472439874045},{"cnt":[[245,382],[1076,382],[1076,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":833,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7cc1ccfc5c4b41b8b212d6b42997af1b","type":"text","conversion_output":true,"text":"multivitamin supplements for a total of 40 weeks.","text_display":" multivitamin supplements for a total of 40 weeks.","confidence":1,"confidence_rate":1},{"cnt":[[269,466],[750,466],[750,522],[269,522]],"region":{"top_left_x":268,"top_left_y":466,"width":482,"height":57},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ee20ea5b16248b2afbde2f68a4209de","type":"section_header","conversion_output":false,"children_ids":["7b278124d7fa4b97a80fc58dc3c73be8"],"text":"","text_display":""},{"cnt":[[275,473],[746,473],[746,518],[275,518]],"region":{"top_left_x":275,"top_left_y":472,"width":471,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b278124d7fa4b97a80fc58dc3c73be8","type":"text","conversion_output":true,"parent_id":"8ee20ea5b16248b2afbde2f68a4209de","text":"9.3 PUSH Intervention","text_display":"\n\n\\subsection*{9.3 PUSH Intervention}","confidence":1,"confidence_rate":1},{"cnt":[[245,518],[1734,518],[1734,565],[245,565]],"region":{"top_left_x":244,"top_left_y":517,"width":1490,"height":49},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eefdc70cbab9401c886c7419eb41b571","type":"text","conversion_output":true,"text":"This intervention is based on improving specific precursors to community ambulation by","text_display":"\n\nThis intervention is based on improving specific precursors to community ambulation by","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1876,563],[1876,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1632,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2768f409c7ad460084672be52069b84f","type":"text","conversion_output":true,"text":"addressing endurance with continuous upright exercise for 20 minutes in duration; function such","text_display":" addressing endurance with continuous upright exercise for 20 minutes in duration; function such","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1820,606],[1820,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1576,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"079947bc3901457cae68fc3023543836","type":"text","conversion_output":true,"text":"as walking, standing from a chair, and stair negotiation; muscle performance by exercising to","text_display":" as walking, standing from a chair, and stair negotiation; muscle performance by exercising to","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,649],[1820,649],[1820,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":1576,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18bed480715f428d93cb1713841a1988","type":"text","conversion_output":true,"text":"enhance lower extremity strength and power in functionally relevant muscles moving through","text_display":" enhance lower extremity strength and power in functionally relevant muscles moving through","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1852,692],[1852,741],[245,741]],"region":{"top_left_x":244,"top_left_y":691,"width":1608,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f7bf387e470479b95e368331783967e","type":"text","conversion_output":true,"text":"locomotion-appropriate movements and ranges; and balance by performing unilateral activities","text_display":" locomotion-appropriate movements and ranges; and balance by performing unilateral activities","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[1796,739],[1796,784],[245,784]],"region":{"top_left_x":244,"top_left_y":739,"width":1553,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54981e931c974979b88f0f52fac4d12c","type":"text","conversion_output":true,"text":"and activities with decreased base of support. These components of exercise will be woven","text_display":" and activities with decreased base of support. These components of exercise will be woven","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1858,782],[1858,829],[245,829]],"region":{"top_left_x":244,"top_left_y":782,"width":1615,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28b62c4d4dae41fcb1c2c5d66e511401","type":"text","conversion_output":true,"text":"together into one program that minimizes participant burden. By the end of the first eight weeks","text_display":" together into one program that minimizes participant burden. By the end of the first eight weeks","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1841,825],[1841,872],[245,872]],"region":{"top_left_x":244,"top_left_y":825,"width":1598,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e9c993c79534338bf146746ec99ff70","type":"text","conversion_output":true,"text":"participants will be instructed to complete the endurance component independently one to two","text_display":" participants will be instructed to complete the endurance component independently one to two","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1846,868],[1846,917],[245,917]],"region":{"top_left_x":244,"top_left_y":867,"width":1602,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13d2d991fd704102a4f68c1b218964f0","type":"text","conversion_output":true,"text":"times/week by walking for a similar duration and intensity as they have been doing with the PT","text_display":" times/week by walking for a similar duration and intensity as they have been doing with the PT","confidence":0.5617372989654541,"confidence_rate":0.9943061629924462},{"cnt":[[245,915],[724,915],[724,965],[245,965]],"region":{"top_left_x":244,"top_left_y":915,"width":481,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"115105bf8f7e4d6baabbc4e33fe3660f","type":"text","conversion_output":true,"text":"during the supervised visits.","text_display":" during the supervised visits.","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1794,1001],[1794,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1550,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f4491a1d1fc462096705be3524f2ea3","type":"text","conversion_output":true,"text":"The strength components of the muscle performance intervention will be performed using a","text_display":"\n\nThe strength components of the muscle performance intervention will be performed using a","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1766,1044],[1766,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":1523,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3d0811d48ad46e29a3f0b4bb5569c62","type":"text","conversion_output":true,"text":"portable progressive resistive exercise device (Shuttle® MiniPress, Contemporary Design","text_display":" portable progressive resistive exercise device (Shuttle® MiniPress, Contemporary Design","confidence":0.9975595474243164,"confidence_rate":0.9999734412729728},{"cnt":[[245,1087],[1790,1087],[1790,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1546,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d4130a31f3e48078c030c6d7fd7c72e","type":"text","conversion_output":true,"text":"Company, P.O. Box 5089, Glacier, WA 98244). The device has six latex bands each with a","text_display":" Company, P.O. Box 5089, Glacier, WA 98244). The device has six latex bands each with a","confidence":0.994631290435791,"confidence_rate":0.9999408460037893},{"cnt":[[245,1130],[1777,1130],[1777,1182],[245,1182]],"region":{"top_left_x":244,"top_left_y":1130,"width":1533,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fe1f3803f10495d98d1d7249feafc65","type":"text","conversion_output":true,"text":"starting load equal to approximately seven pounds. At full excursion one band can provide","text_display":" starting load equal to approximately seven pounds. At full excursion one band can provide","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1850,1177],[1850,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1177,"width":1606,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f89742e8fed645a1abc85402c1a83cd8","type":"text","conversion_output":true,"text":"approximately 15 pounds of force. These bands provide the resistance and are attached to the","text_display":" approximately 15 pounds of force. These bands provide the resistance and are attached to the","confidence":0.9946346282958984,"confidence_rate":0.9999462032770593},{"cnt":[[245,1220],[1837,1220],[1837,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1220,"width":1593,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b299ea51f5384fbeb4faf2fd86cbafc0","type":"text","conversion_output":true,"text":"machine by a slotted bar on the frame. Inserting more bands into the slotted bar increases the","text_display":" machine by a slotted bar on the frame. Inserting more bands into the slotted bar increases the","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1824,1263],[1824,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1263,"width":1581,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0df3ebd24254aaa8441a6b264b2d8a1","type":"text","conversion_output":true,"text":"resistive load for the participant. A progress monitor strip is located on the top of the machine","text_display":" resistive load for the participant. A progress monitor strip is located on the top of the machine","confidence":1,"confidence_rate":1},{"cnt":[[245,1308],[1807,1308],[1807,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1308,"width":1563,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8523dac28f4042c0a29aabe7aa432194","type":"text","conversion_output":true,"text":"frame. Strips indicate resistance by showing distance that the load is moved. The resistance","text_display":" frame. Strips indicate resistance by showing distance that the load is moved. The resistance","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1867,1354],[1867,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1623,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08206f7558104b938f49c067f023ec4a","type":"text","conversion_output":true,"text":"numbers indicate the force for one band as the carriage is moved. When more than one band is","text_display":" numbers indicate the force for one band as the carriage is moved. When more than one band is","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[819,1392],[819,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1392,"width":575,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1dc3494add924af5a39765a5d3601789","type":"text","conversion_output":true,"text":"used, the values will be added. \\({ }^{137}\\)","text_display":" used, the values will be added. \\({ }^{137}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1485],[1815,1485],[1815,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1484,"width":1572,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28a9849c2bcd47eaa8ca3572ae93d963","type":"text","conversion_output":true,"text":"Muscle performance will focus on bilateral hip extensors, hip abductors, knee extensors, and","text_display":"\n\nMuscle performance will focus on bilateral hip extensors, hip abductors, knee extensors, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1865,1525],[1865,1577],[245,1577]],"region":{"top_left_x":244,"top_left_y":1525,"width":1621,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5901a855d8c43f8bb60f9def2c73e19","type":"text","conversion_output":true,"text":"plantar flexors because of their role in function, specifically gait and transfer activities. \\({ }^{138-140}\\) Hip","text_display":" plantar flexors because of their role in function, specifically gait and transfer activities. \\({ }^{138-140}\\) Hip","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1781,1573],[1781,1620],[245,1620]],"region":{"top_left_x":244,"top_left_y":1572,"width":1538,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0072161347942d8a27171190ebac9eb","type":"text","conversion_output":true,"text":"and knee extensor muscle will be trained to work hard and fast during the leg press motion","text_display":" and knee extensor muscle will be trained to work hard and fast during the leg press motion","confidence":1,"confidence_rate":1},{"cnt":[[245,1616],[1841,1616],[1841,1663],[245,1663]],"region":{"top_left_x":244,"top_left_y":1615,"width":1598,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16a9c61950af4e4ab41cf59dc8d18ac8","type":"text","conversion_output":true,"text":"since this mimics the functional activity of rising from a chair or going up a step. Hip abductors","text_display":" since this mimics the functional activity of rising from a chair or going up a step. Hip abductors","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1850,1659],[1850,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1658,"width":1606,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cfbd795b6be4d5f86810cc0aa7b94df","type":"text","conversion_output":true,"text":"will be trained in \\(5^{\\circ}\\) of adduction and to \\(10-15^{\\circ}\\) of abduction. Fifteen degrees of movement was","text_display":" will be trained in \\(5^{\\circ}\\) of adduction and to \\(10-15^{\\circ}\\) of abduction. Fifteen degrees of movement was","confidence":0.99951171875,"confidence_rate":0.9999958958025558},{"cnt":[[245,1704],[1820,1704],[1820,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1703,"width":1576,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f8942ae9b3c4e4194eb7e7c3e4d0850","type":"text","conversion_output":true,"text":"chosen because it approximates the \\(8^{\\circ}\\) of motion associated with gait and takes into account","text_display":" chosen because it approximates the \\(8^{\\circ}\\) of motion associated with gait and takes into account","confidence":1,"confidence_rate":1},{"cnt":[[245,1745],[1846,1745],[1846,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1744,"width":1602,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cefd88d2cf73478896a8c6a7d6a63d0c","type":"text","conversion_output":true,"text":"variations in hip positions while standing. \\({ }^{141}\\) Hip extension will also be trained in standing from","text_display":" variations in hip positions while standing. \\({ }^{141}\\) Hip extension will also be trained in standing from","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1794,1792],[1794,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1550,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"206bdaf6634f4e99820e6a6e989584ed","type":"text","conversion_output":true,"text":"\\(35^{\\circ}\\) of flexion to extension to a neutral position. This ROM approximates the time in the gait","text_display":" \\(35^{\\circ}\\) of flexion to extension to a neutral position. This ROM approximates the time in the gait","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1768,1835],[1768,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1525,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f7babb35bd94c9dad273c703753b801","type":"text","conversion_output":true,"text":"cycle when the gluteus maximus shows the highest muscle activity, i.e., from heel contact","text_display":" cycle when the gluteus maximus shows the highest muscle activity, i.e., from heel contact","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1858,1878],[1858,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1877,"width":1615,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b86c386fac846b486217b130b531b4a","type":"text","conversion_output":true,"text":"through \\(20 \\%\\) of stride. \\({ }^{139}\\) Plantar flexors will be strengthened in standing against body weight \\({ }^{77}\\)","text_display":" through \\(20 \\%\\) of stride. \\({ }^{139}\\) Plantar flexors will be strengthened in standing against body weight \\({ }^{77}\\)","confidence":0.9682769775390625,"confidence_rate":0.9997357963930635},{"cnt":[[245,1921],[1841,1921],[1841,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1920,"width":1598,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a5d6ed8f9d14393b1142c0ef2225d23","type":"text","conversion_output":true,"text":"because of their role in the push-off phase of gait and the strong association of plantar flexion","text_display":" because of their role in the push-off phase of gait and the strong association of plantar flexion","confidence":1,"confidence_rate":1},{"cnt":[[245,1966],[1820,1966],[1820,2015],[245,2015]],"region":{"top_left_x":244,"top_left_y":1965,"width":1576,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbc37f67a0d24fe89d97f05ca125f26b","type":"text","conversion_output":true,"text":"power and walking speed. \\({ }^{77,138-142}\\) The intensity of strength training will be determined during","text_display":" power and walking speed. \\({ }^{77,138-142}\\) The intensity of strength training will be determined during","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1742,2011],[1742,2058],[245,2058]],"region":{"top_left_x":244,"top_left_y":2010,"width":1499,"height":49},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"742406f88449437b894980aaabd67557","type":"text","conversion_output":true,"text":"Day 1 of intervention at the participant's residence. The PT will determine the amount of","text_display":" Day 1 of intervention at the participant's residence. The PT will determine the amount of","confidence":0.89013671875,"confidence_rate":0.9988009234728008},{"cnt":[[245,2054],[1772,2054],[1772,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2053,"width":1529,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b1e3faaf34b4e9fa934d9af60794807","type":"text","conversion_output":true,"text":"resistance the participant can push against so that s/he can complete a maximum of eight","text_display":" resistance the participant can push against so that s/he can complete a maximum of eight","confidence":0.953125,"confidence_rate":0.9994839050595387},{"cnt":[[245,2099],[1852,2099],[1852,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2099,"width":1608,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0135928846174905bfacb7952b26212f","type":"text","conversion_output":true,"text":"repetitions (eight repetitions maximum (RM) or 8 -RM). 8 -RM was chosen because it is strongly","text_display":" repetitions (eight repetitions maximum (RM) or 8 -RM). 8 -RM was chosen because it is strongly","confidence":0.7861419963255407,"confidence_rate":0.9977110251743581},{"cnt":[[245,2142],[1852,2142],[1852,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2141,"width":1608,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7283bb09374c41d4a9f7e35db155c86e","type":"text","conversion_output":true,"text":"related to the \\(1- RM ^{143}\\) and determining the \\(8- RM\\) will allow the PT to know the training intensity","text_display":" related to the \\(1- RM ^{143}\\) and determining the \\(8- RM\\) will allow the PT to know the training intensity","confidence":0.9604609034727218,"confidence_rate":0.9996798766317644},{"cnt":[[245,2187],[1824,2187],[1824,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2187,"width":1581,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b07ae2bac6a54b93af9d83ccc1403de4","type":"text","conversion_output":true,"text":"without further sub-calculations (e.g. \\(80 \\%\\) of the 1 -RM). Studies have shown that the 8 -RM is","text_display":" without further sub-calculations (e.g. \\(80 \\%\\) of the 1 -RM). Studies have shown that the 8 -RM is","confidence":0.7042448525317013,"confidence_rate":0.9967586979039287},{"cnt":[[245,2230],[1807,2230],[1807,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1563,"height":50},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51bb03dda565408799992dafa1207185","type":"text","conversion_output":true,"text":"more effective than training at \\(10- RM\\) or \\(2- RM ^{88}\\) yet is not so aggressive that it is associated","text_display":" more effective than training at \\(10- RM\\) or \\(2- RM ^{88}\\) yet is not so aggressive that it is associated","confidence":0.6441470315043245,"confidence_rate":0.9962795797637276},{"cnt":[[245,2273],[1861,2273],[1861,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2273,"width":1617,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c5fbfbb26cf41e6a359ee7f06d86884","type":"text","conversion_output":true,"text":"with injuries. \\({ }^{144,145}\\) This protocol has been used safely and effectively in elders \\({ }^{21,73,74,77,140,146}\\) and","text_display":" with injuries. \\({ }^{144,145}\\) This protocol has been used safely and effectively in elders \\({ }^{21,73,74,77,140,146}\\) and","confidence":0.9970729344058782,"confidence_rate":0.9999777929903033},{"cnt":[[245,2316],[1828,2316],[1828,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2316,"width":1585,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db545713926d4bd69c6b4dffdb3afbe7","type":"text","conversion_output":true,"text":"specifically in persons post-hip fracture. \\({ }^{29,70}\\) For the first visit, participants will be tested to find","text_display":" specifically in persons post-hip fracture. \\({ }^{29,70}\\) For the first visit, participants will be tested to find","confidence":1,"confidence_rate":1},{"cnt":[[245,2363],[1777,2363],[1777,2411],[245,2411]],"region":{"top_left_x":244,"top_left_y":2363,"width":1533,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d35393911af04939a8fd6e827ec07188","type":"text","conversion_output":true,"text":"the load associated with an intensity of 8 -RM. During the second session, participants will","text_display":" the load associated with an intensity of 8 -RM. During the second session, participants will","confidence":0.937187671661377,"confidence_rate":0.9993514931028313},{"cnt":[[245,2406],[1725,2406],[1725,2456],[245,2456]],"region":{"top_left_x":244,"top_left_y":2406,"width":1482,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aee14ef7e61f4c0885301a6307efb0d2","type":"text","conversion_output":true,"text":"perform 2 sets of 8 repetitions at the 8 -RM intensity. From the third session through the","text_display":" perform 2 sets of 8 repetitions at the 8 -RM intensity. 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Shuttle Device (arrows indicate direction of lower extremity motion)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,262],[1485,262],[1485,578],[243,578]],"region":{"top_left_x":242,"top_left_y":262,"width":1243,"height":316},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fec31b8b3df2485b9d6a1566b7d8473e","type":"diagram","conversion_output":true,"selected_labels":["79565d49dedc4a8aa827e71cb0f4e48f"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 3. 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The PT will","confidence":0.6122231483459473,"confidence_rate":0.9788929627128357},{"cnt":[[1560,296],[1807,296],[1807,342],[1560,342]],"region":{"top_left_x":1559,"top_left_y":296,"width":248,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16a4626495fa428eb04542e3cee31ebd","type":"text","conversion_output":true,"parent_id":"daede6eba67149b6b1cc038eebcc78b5","text":"provide strong","text_display":" provide strong","confidence":1,"confidence_rate":1},{"cnt":[[1560,339],[1669,339],[1669,380],[1560,380]],"region":{"top_left_x":1559,"top_left_y":339,"width":111,"height":42},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e22342d934a4b0e9480997e78a2d8c2","type":"text","conversion_output":true,"parent_id":"daede6eba67149b6b1cc038eebcc78b5","text":"verbal","text_display":" verbal","confidence":1,"confidence_rate":1},{"cnt":[[1560,387],[1833,387],[1833,432],[1560,432]],"region":{"top_left_x":1559,"top_left_y":386,"width":274,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed1e98d6e0564f208b023287babf8969","type":"text","conversion_output":true,"parent_id":"daede6eba67149b6b1cc038eebcc78b5","text":"encouragement","text_display":" encouragement","confidence":1,"confidence_rate":1},{"cnt":[[1560,430],[1764,430],[1764,475],[1560,475]],"region":{"top_left_x":1559,"top_left_y":429,"width":205,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06c057a4ef89418ab7f20edae38da9c6","type":"text","conversion_output":true,"parent_id":"daede6eba67149b6b1cc038eebcc78b5","text":"during each","text_display":" during each","confidence":1,"confidence_rate":1},{"cnt":[[1560,473],[1841,473],[1841,518],[1560,518]],"region":{"top_left_x":1559,"top_left_y":472,"width":283,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13ba50f388074574b5638be36aaab40a","type":"text","conversion_output":true,"parent_id":"daede6eba67149b6b1cc038eebcc78b5","text":"repetition for the","text_display":" repetition for the","confidence":1,"confidence_rate":1},{"cnt":[[1560,516],[1785,516],[1785,561],[1560,561]],"region":{"top_left_x":1559,"top_left_y":515,"width":227,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9437201609f04bbdb94f9913160bd843","type":"text","conversion_output":true,"parent_id":"daede6eba67149b6b1cc038eebcc78b5","text":"participant to","text_display":" participant to","confidence":1,"confidence_rate":1},{"cnt":[[1560,559],[1871,559],[1871,599],[1560,599]],"region":{"top_left_x":1559,"top_left_y":558,"width":313,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3924a7e7743a4dcbb03def08c63195da","type":"text","conversion_output":true,"parent_id":"daede6eba67149b6b1cc038eebcc78b5","text":"move as \"fast and","text_display":" move as \"fast and","confidence":1,"confidence_rate":1},{"cnt":[[245,604],[1852,604],[1852,649],[245,649]],"region":{"top_left_x":244,"top_left_y":603,"width":1608,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc43e38699de4699b6287e9b6d33a321","type":"text","conversion_output":true,"text":"as hard as possible\" during the concentric phase and to move slowly and in a controlled way in","text_display":"\nas hard as possible\" during the concentric phase and to move slowly and in a controlled way in","confidence":0.99560546875,"confidence_rate":0.9999555139634225},{"cnt":[[245,649],[1330,649],[1330,694],[245,694]],"region":{"top_left_x":244,"top_left_y":648,"width":1086,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bacff9503374fe297197882339cd7a2","type":"text","conversion_output":true,"text":"the eccentric phase. Intensity will be reviewed every two weeks.","text_display":" the eccentric phase. Intensity will be reviewed every two weeks.","confidence":0.99658203125,"confidence_rate":0.9999503806028286},{"cnt":[[245,735],[1798,735],[1798,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1555,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d65ca4c3b6a343418b7e38e50d46c8b2","type":"text","conversion_output":true,"text":"The participants will be supine for two exercises: the combination of hip and knee extension","text_display":"\n\nThe participants will be supine for two exercises: the combination of hip and knee extension","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1850,778],[1850,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1606,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c44d71baee2444c3a85e2558b8589e6b","type":"text","conversion_output":true,"text":"exercise (leg press) and the hip abduction exercise (Figure 3a \\& 3b). The device will be placed","text_display":" exercise (leg press) and the hip abduction exercise (Figure 3a \\& 3b). The device will be placed","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1826,821],[1826,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1583,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84e643f476cd44d7b96c1b91f200443a","type":"text","conversion_output":true,"text":"on the bed or floor (if the participant is able to be assisted safely to and from the floor) so that","text_display":" on the bed or floor (if the participant is able to be assisted safely to and from the floor) so that","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1824,868],[1824,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1581,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b00f38b7784f4f89af8a9ce8fe486182","type":"text","conversion_output":true,"text":"the participant's foot will rest on the footplate and the hip will be flexed to \\(90^{\\circ}\\). The participant","text_display":" the participant's foot will rest on the footplate and the hip will be flexed to \\(90^{\\circ}\\). The participant","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1858,911],[1858,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1615,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6df623916c014098a610c425873481d3","type":"text","conversion_output":true,"text":"will push the leg out into full hip and knee extension against the pre-determined resistance. For","text_display":" will push the leg out into full hip and knee extension against the pre-determined resistance. For","confidence":0.998046875,"confidence_rate":0.9999808331754918},{"cnt":[[245,954],[1846,954],[1846,999],[245,999]],"region":{"top_left_x":244,"top_left_y":953,"width":1602,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d5cafb119c343fe9a5ac88a98149818","type":"text","conversion_output":true,"text":"the hip abductors, the participant will start in \\(5^{\\circ}\\) of adduction and move \\(15^{\\circ}\\) into abduction. The","text_display":" the hip abductors, the participant will start in \\(5^{\\circ}\\) of adduction and move \\(15^{\\circ}\\) into abduction. The","confidence":1,"confidence_rate":1},{"cnt":[[245,999],[1777,999],[1777,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":999,"width":1533,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0f6d6d5646147f0b3cd4eb5cfd6d0c2","type":"text","conversion_output":true,"text":"participant's foot will be strapped to the footplate as the participant moves the leg outward.","text_display":" participant's foot will be strapped to the footplate as the participant moves the leg outward.","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1087],[1807,1087],[1807,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1563,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50c82479d0624506ae2431762a9190bf","type":"text","conversion_output":true,"text":"Balance and strength will be addressed with two additional exercises performed in standing.","text_display":"\n\nBalance and strength will be addressed with two additional exercises performed in standing.","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1858,1130],[1858,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1615,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14578177d3684035895eeb628a9bfb6f","type":"text","conversion_output":true,"text":"Balance will be addressed by asking the participant to perform one-legged activities or to stand","text_display":" Balance will be addressed by asking the participant to perform one-legged activities or to stand","confidence":1,"confidence_rate":1},{"cnt":[[245,1175],[1858,1175],[1858,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1175,"width":1615,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5e4c707c03544759c0b1e056317076f","type":"text","conversion_output":true,"text":"upright with a decreased base of support. The first exercise that combines balance training and","text_display":" upright with a decreased base of support. The first exercise that combines balance training and","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1858,1216],[1858,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1615,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f49b8cde4764af28873a20d7a758d7f","type":"text","conversion_output":true,"text":"strength training will be standing hip extension (Figure 3c). The leg will be flexed approximately","text_display":" strength training will be standing hip extension (Figure 3c). The leg will be flexed approximately","confidence":1,"confidence_rate":1},{"cnt":[[245,1261],[1708,1261],[1708,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1261,"width":1465,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5a62ddce9bc4143bc1895dd05f441b7","type":"text","conversion_output":true,"text":"\\(35^{\\circ}\\) of flexion and the participant will extend to neutral position. Upright balance will be","text_display":" \\(35^{\\circ}\\) of flexion and the participant will extend to neutral position. 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Balance and strength","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1762,1568],[1762,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1518,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43615cc77b734467934cf79e0a089646","type":"text","conversion_output":true,"text":"will be progressively challenged by advancing the activity to unilateral heel raises. For hip","text_display":" will be progressively challenged by advancing the activity to unilateral heel raises. 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Resistance (load in pounds) and repetitions for each exercise performed will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1745],[711,1745],[711,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1744,"width":468,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59b9091cfe9045e59996b3055d507af2","type":"text","conversion_output":true,"text":"recorded in a training log. \\({ }^{29}\\)","text_display":" recorded in a training log. \\({ }^{29}\\)","confidence":0.99951171875,"confidence_rate":0.9999880878636791},{"cnt":[[245,1830],[1841,1830],[1841,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1830,"width":1598,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4878a51450548d887784bbb9477cb96","type":"text","conversion_output":true,"text":"HR will be measured by palpation of the radial artery recorded every five minutes and it will be","text_display":"\n\nHR will be measured by palpation of the radial artery recorded every five minutes and it will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1876],[1815,1876],[1815,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1875,"width":1572,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0aff0b49f30745e4ae6c4dda92d4f4f7","type":"text","conversion_output":true,"text":"averaged over 20 minutes of continuous exercise. The PT will calculate the HR training zone","text_display":" averaged over 20 minutes of continuous exercise. The PT will calculate the HR training zone","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1828,1921],[1828,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1585,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f54438d76abd4589b1bc7f4f037d68d7","type":"text","conversion_output":true,"text":"based on the heart rate reserve (HRR) method (HR max-HR rest) multiplied by \\(50 \\%\\) and then","text_display":" based on the heart rate reserve (HRR) method (HR max-HR rest) multiplied by \\(50 \\%\\) and then","confidence":0.9990234375,"confidence_rate":0.999989822555459},{"cnt":[[245,1964],[1687,1964],[1687,2009],[245,2009]],"region":{"top_left_x":244,"top_left_y":1963,"width":1443,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1054848aa13a4cb7b3d4cebda4c5ecd0","type":"text","conversion_output":true,"text":"added to HR rest. HR max will be calculated as 220 minus the participant's age. This","text_display":" added to HR rest. HR max will be calculated as 220 minus the participant's age. This","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1785,2007],[1785,2054],[245,2054]],"region":{"top_left_x":244,"top_left_y":2006,"width":1542,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a806eca8b5f4172bba63a6313295584","type":"text","conversion_output":true,"text":"prescription is consistent with moderate intensity exercise and has been shown to increase","text_display":" prescription is consistent with moderate intensity exercise and has been shown to increase","confidence":1,"confidence_rate":1},{"cnt":[[245,2050],[1841,2050],[1841,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2049,"width":1598,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d33f9b00431e4b81a5c2b9455d78006f","type":"text","conversion_output":true,"text":"aerobic capacity in elders. \\({ }^{147-149}\\) If the person is taking medication that controls heart rate (e.g.,","text_display":" aerobic capacity in elders. \\({ }^{147-149}\\) If the person is taking medication that controls heart rate (e.g.,","confidence":0.99951171875,"confidence_rate":0.999995825645481},{"cnt":[[245,2093],[1820,2093],[1820,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2092,"width":1576,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37cb2e6c3f9f498caa8f1d4250c2cab5","type":"text","conversion_output":true,"text":"beta-blockers), Borg's Rating of Perceived Exertion (RPE) scale will be used. \\({ }^{150}\\) The training","text_display":" beta-blockers), Borg's Rating of Perceived Exertion (RPE) scale will be used. \\({ }^{150}\\) The training","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[245,2140],[1876,2140],[1876,2187],[245,2187]],"region":{"top_left_x":244,"top_left_y":2139,"width":1632,"height":49},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf6f80d5afe34338b92405bddaad46c1","type":"text","conversion_output":true,"text":"intensity using the RPE scale will be \"moderate\" work as consistent with a \\(3-5\\) on the \\(0-10\\) scale.","text_display":" intensity using the RPE scale will be \"moderate\" work as consistent with a \\(3-5\\) on the \\(0-10\\) scale.","confidence":0.99853515625,"confidence_rate":0.999986426780242},{"cnt":[[245,2228],[1865,2228],[1865,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2227,"width":1621,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca44da0e4f404e54aa3126a67f376961","type":"text","conversion_output":true,"text":"The endurance intervention will begin initially with two to three minutes of continuous upper and","text_display":"\n\nThe endurance intervention will begin initially with two to three minutes of continuous upper and","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1861,2273],[1861,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1617,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9749765c9a504c9996d5957db7d9d927","type":"text","conversion_output":true,"text":"lower extremity AROM with the participant sitting. These exercises are intended to increase the","text_display":" lower extremity AROM with the participant sitting. These exercises are intended to increase the","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1854,2316],[1854,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":1611,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"649a6bc01e4e44659666586b888807c7","type":"text","conversion_output":true,"text":"participants' HR or exertion closer to the target zone. The participant will then be asked to walk","text_display":" participants' HR or exertion closer to the target zone. The participant will then be asked to walk","confidence":1,"confidence_rate":1},{"cnt":[[245,2359],[1798,2359],[1798,2404],[245,2404]],"region":{"top_left_x":244,"top_left_y":2358,"width":1555,"height":47},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"562835b5befc486e9ce17077291d5ac8","type":"text","conversion_output":true,"text":"on level surfaces and up and down one or more steps, if able and available, to keep the HR","text_display":" on level surfaces and up and down one or more steps, if able and available, to keep the HR","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1798,2402],[1798,2449],[245,2449]],"region":{"top_left_x":244,"top_left_y":2401,"width":1555,"height":49},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d041a03e5ec2496f9b7ab8b40b2a8f64","type":"text","conversion_output":true,"text":"within the training zone for 20 minutes. The PT can also engage the participant in additional","text_display":" within the training zone for 20 minutes. The PT can also engage the participant in additional","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,2447],[1811,2447],[1811,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2447,"width":1568,"height":48},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab85a8ed1c184bc584736c9885f7f09d","type":"text","conversion_output":true,"text":"exercises such as upper and lower extremity AROM exercises to keep the HR elevated. The","text_display":" exercises such as upper and lower extremity AROM exercises to keep the HR elevated. The","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae43e41fca994c68abdd0bfdc12279d0","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1833,2587],[1886,2587],[1886,2628],[1833,2628]],"region":{"top_left_x":1832,"top_left_y":2586,"width":55,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b390b6bba2604447a0187e9c1dec26a1","type":"page_info","conversion_output":false,"text":"28","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-048","page":48,"lines":[{"cnt":[[245,249],[1871,249],[1871,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1628,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd6887bce7514d86a3d088587cb91eaa","type":"text","conversion_output":true,"text":"target HR will be \\(30 \\%\\) of HRR in the first week of the program, \\(40 \\%\\) of HRR in the second week,","text_display":"\ntarget HR will be \\(30 \\%\\) of HRR in the first week of the program, \\(40 \\%\\) of HRR in the second week,","confidence":0.5297170361108026,"confidence_rate":0.9939088927279158},{"cnt":[[245,296],[935,296],[935,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":691,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44af6c4db8394c358aa7160dc0f32ddd","type":"text","conversion_output":true,"text":"and \\(50 \\%\\) of HRR in weeks 3 through 16.","text_display":" and \\(50 \\%\\) of HRR in weeks 3 through 16.","confidence":0.90869140625,"confidence_rate":0.997964845453482},{"cnt":[[271,380],[771,380],[771,432],[271,432]],"region":{"top_left_x":270,"top_left_y":380,"width":502,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0a8fa47b4374dbe9585f90d6da9bd3c","type":"section_header","conversion_output":false,"children_ids":["df14ff6fa56642f0921d5a2210a94a5e"],"text":"","text_display":""},{"cnt":[[275,385],[767,385],[767,428],[275,428]],"region":{"top_left_x":275,"top_left_y":384,"width":492,"height":44},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df14ff6fa56642f0921d5a2210a94a5e","type":"text","conversion_output":true,"parent_id":"a0a8fa47b4374dbe9585f90d6da9bd3c","text":"9.4 PULSE Intervention","text_display":"\n\n\\subsection*{9.4 PULSE Intervention}","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1837,430],[1837,477],[245,477]],"region":{"top_left_x":244,"top_left_y":429,"width":1593,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c34a63881ae04fc987095877f32bae76","type":"text","conversion_output":true,"text":"The PULSE intervention group will receive flexibility exercises, AROM for the upper and lower","text_display":"\n\nThe PULSE intervention group will receive flexibility exercises, AROM for the upper and lower","confidence":1,"confidence_rate":1},{"cnt":[[245,475],[1807,475],[1807,522],[245,522]],"region":{"top_left_x":244,"top_left_y":474,"width":1563,"height":49},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe08a3faf25b44dd921b79130f5eb7e6","type":"text","conversion_output":true,"text":"extremities, breathing exercises and TENS. During the AROM exercises, participants will be","text_display":" extremities, breathing exercises and TENS. During the AROM exercises, participants will be","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1867,520],[1867,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":1623,"height":47},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"471adae853cd4f2db44060694d2d8337","type":"text","conversion_output":true,"text":"working to increase flexibility and range of motion in order to increase the motion the participant","text_display":" working to increase flexibility and range of motion in order to increase the motion the participant","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1841,563],[1841,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1598,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b81bb0d5c6314a3e863351885a099783","type":"text","conversion_output":true,"text":"produces. The exercises will include the neck, shoulders, arms, trunk, hips, knees and ankles.","text_display":" produces. The exercises will include the neck, shoulders, arms, trunk, hips, knees and ankles.","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1768,606],[1768,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1525,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a33bdadda34d4cb9aa8e2241a03d5a55","type":"text","conversion_output":true,"text":"During all of the AROM exercises, the participant will focus on deep breathing techniques.","text_display":" During all of the AROM exercises, the participant will focus on deep breathing techniques.","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1798,649],[1798,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":1555,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"660587f8494d4761bd05753d616fe589","type":"text","conversion_output":true,"text":"Progression will be gradual by beginning with three repetitions and slowly progressing to 10","text_display":" Progression will be gradual by beginning with three repetitions and slowly progressing to 10","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,694],[1876,694],[1876,741],[245,741]],"region":{"top_left_x":244,"top_left_y":693,"width":1632,"height":49},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"177f29443cd940f0ab78cd16499dd09c","type":"text","conversion_output":true,"text":"reps. We will add a second set of exercises when necessary. This portion of the session will last","text_display":" reps. We will add a second set of exercises when necessary. This portion of the session will last","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[754,739],[754,784],[245,784]],"region":{"top_left_x":244,"top_left_y":739,"width":511,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6965d7afa9347cbafc17f8865e209f2","type":"text","conversion_output":true,"text":"approximately \\(20-30\\) minutes.","text_display":" approximately \\(20-30\\) minutes.","confidence":0.99853515625,"confidence_rate":0.9999592808934205},{"cnt":[[245,825],[1876,825],[1876,874],[245,874]],"region":{"top_left_x":244,"top_left_y":825,"width":1632,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec8a3c1305f8490d9b07f5f9cdf267e0","type":"text","conversion_output":true,"text":"The second part of the session will use sensory level electrical stimulation to the lower extremity","text_display":"\n\nThe second part of the session will use sensory level electrical stimulation to the lower extremity","confidence":1,"confidence_rate":1},{"cnt":[[245,870],[1807,870],[1807,917],[245,917]],"region":{"top_left_x":244,"top_left_y":870,"width":1563,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"185e9bf566a548e0b8948129f6d48a25","type":"text","conversion_output":true,"text":"muscle groups. The TENS portion of intervention is intended to decrease pain and increase","text_display":" muscle groups. The TENS portion of intervention is intended to decrease pain and increase","confidence":0.95654296875,"confidence_rate":0.9995274567027598},{"cnt":[[245,915],[1878,915],[1878,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1634,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2df83e23a61469fb958472ab0f548c0","type":"text","conversion_output":true,"text":"muscle recruitment thereby allowing greater ease of mobility. Conventional TENS uses low-level","text_display":" muscle recruitment thereby allowing greater ease of mobility. Conventional TENS uses low-level","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[1876,958],[1876,1005],[245,1005]],"region":{"top_left_x":244,"top_left_y":958,"width":1632,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe67062aace24ae5bc526e3af66a1f62","type":"text","conversion_output":true,"text":"electrical current to stimulate superficial cutaneous nerve fibers through the skin. The amount of","text_display":" electrical current to stimulate superficial cutaneous nerve fibers through the skin. The amount of","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1781,1001],[1781,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1538,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51d4d620adaf4538adb3826850c0c867","type":"text","conversion_output":true,"text":"current for sensory level stimulation is the level which the participant detects as a \"tingling\"","text_display":" current for sensory level stimulation is the level which the participant detects as a \"tingling\"","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1721,1044],[1721,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":1477,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20c5d4fe214341909ca80b5f84179502","type":"text","conversion_output":true,"text":"sensation and is not high enough to produce a visible muscle contraction (below motor","text_display":" sensation and is not high enough to produce a visible muscle contraction (below motor","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1772,1087],[1772,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1529,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ae3f766f3eb4303aaadf7ee6c9b93f0","type":"text","conversion_output":true,"text":"threshold). \\({ }^{5}\\) To achieve sensory level stimulation, we will use a frequency of 80 pulses per","text_display":" threshold). \\({ }^{5}\\) To achieve sensory level stimulation, we will use a frequency of 80 pulses per","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[1772,1134],[1772,1182],[245,1182]],"region":{"top_left_x":244,"top_left_y":1134,"width":1529,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dcf8d98e1ce48dc9c42df1c70be9660","type":"text","conversion_output":true,"text":"second, pulse duration \\(50 \\mu sec\\), and amplitude which produces a comfortable paresthesia","text_display":" second, pulse duration \\(50 \\mu sec\\), and amplitude which produces a comfortable paresthesia","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1811,1177],[1811,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1177,"width":1568,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c75ddf6adba946c4b6602fa14b981ca0","type":"text","conversion_output":true,"text":"(tingling or 'pins and needles' sensation). Flexible carbonized, disposable electrodes coated","text_display":" (tingling or 'pins and needles' sensation). Flexible carbonized, disposable electrodes coated","confidence":1,"confidence_rate":1},{"cnt":[[245,1222],[1880,1222],[1880,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1222,"width":1636,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84eb7f1de83b478eb5943e908ad6e82d","type":"text","conversion_output":true,"text":"with a self-adhesive conductive polymer will be applied to the skin. The electrodes will be placed","text_display":" with a self-adhesive conductive polymer will be applied to the skin. The electrodes will be placed","confidence":1,"confidence_rate":1},{"cnt":[[245,1265],[1867,1265],[1867,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1265,"width":1623,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd108d2870a24f068971c29e580d9123","type":"text","conversion_output":true,"text":"bilaterally near the motor points on muscle bellies (the gluteal complex, the quadriceps, and the","text_display":" bilaterally near the motor points on muscle bellies (the gluteal complex, the quadriceps, and the","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1880,1311],[1880,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1310,"width":1636,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e90b62ca5163401599c273e6ab89f752","type":"text","conversion_output":true,"text":"gastrocnemius) for seven minutes per muscle group. The muscle regions selected are important","text_display":" gastrocnemius) for seven minutes per muscle group. The muscle regions selected are important","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1865,1354],[1865,1401],[245,1401]],"region":{"top_left_x":244,"top_left_y":1353,"width":1621,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55f481fcb05345b5aac6057e8f057088","type":"text","conversion_output":true,"text":"for function after hip fracture. Repetitions and duration of the AROM program, as well as TENS","text_display":" for function after hip fracture. Repetitions and duration of the AROM program, as well as TENS","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[982,1396],[982,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":738,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb7b097aa5c94618b34d59fe98397bb9","type":"text","conversion_output":true,"text":"intensity will be recorded in the training log.","text_display":" intensity will be recorded in the training log.","confidence":1,"confidence_rate":1},{"cnt":[[271,1480],[844,1480],[844,1540],[271,1540]],"region":{"top_left_x":270,"top_left_y":1480,"width":575,"height":61},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d77e130a305b4fefa49b32ca6f21ec90","type":"section_header","conversion_output":false,"children_ids":["1048f4faebb44e6a9ce863253a6077a1"],"text":"","text_display":""},{"cnt":[[275,1487],[838,1487],[838,1536],[275,1536]],"region":{"top_left_x":275,"top_left_y":1486,"width":563,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1048f4faebb44e6a9ce863253a6077a1","type":"text","conversion_output":true,"parent_id":"d77e130a305b4fefa49b32ca6f21ec90","text":"9.5 Treatment Fidelity Plan","text_display":"\n\n\\subsection*{9.5 Treatment Fidelity Plan}","confidence":1,"confidence_rate":1},{"cnt":[[245,1532],[1824,1532],[1824,1579],[245,1579]],"region":{"top_left_x":244,"top_left_y":1531,"width":1581,"height":49},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b2c823413cb40c8b33f05f9a081f804","type":"text","conversion_output":true,"text":"Treatment fidelity \\({ }^{151,152}\\) will be evaluated with regard to: (1) design, which focuses on whether","text_display":"\n\nTreatment fidelity \\({ }^{151,152}\\) will be evaluated with regard to: (1) design, which focuses on whether","confidence":0.9951171875,"confidence_rate":0.9999562976301841},{"cnt":[[245,1577],[1755,1577],[1755,1624],[245,1624]],"region":{"top_left_x":244,"top_left_y":1576,"width":1512,"height":49},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"834f4900434b4c0097b400ac0b49336a","type":"text","conversion_output":true,"text":"the interventions are consistent with underlying theories, and whether the study is free of","text_display":" the interventions are consistent with underlying theories, and whether the study is free of","confidence":1,"confidence_rate":1},{"cnt":[[245,1620],[1738,1620],[1738,1669],[245,1669]],"region":{"top_left_x":244,"top_left_y":1619,"width":1495,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06cc312d379141df9fbe5194d3cec251","type":"text","conversion_output":true,"text":"contamination such as treatment crossover or unintended motivational interventions; (2)","text_display":" contamination such as treatment crossover or unintended motivational interventions; (2)","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,1663],[1704,1663],[1704,1712],[245,1712]],"region":{"top_left_x":244,"top_left_y":1662,"width":1460,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb99af6f7e164e59b56e9cc3ce40de34","type":"text","conversion_output":true,"text":"training, which addresses skill acquisition and maintenance in PTs; (3) delivery, or the","text_display":" training, which addresses skill acquisition and maintenance in PTs; (3) delivery, or the","confidence":1,"confidence_rate":1},{"cnt":[[245,1710],[1880,1710],[1880,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1710,"width":1636,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6bf75d0d5a1a41c9ae2be61a7a08c3a0","type":"text","conversion_output":true,"text":"assessment that the two interventions were implemented as intended; (4) receipt, which focuses","text_display":" assessment that the two interventions were implemented as intended; (4) receipt, which focuses","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[1878,1753],[1878,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1753,"width":1634,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7c6a2af65a1421f8c33b13ff184aa80","type":"text","conversion_output":true,"text":"on whether or not the participant understood and received the intervention as intended. Overall,","text_display":" on whether or not the participant understood and received the intervention as intended. Overall,","confidence":1,"confidence_rate":1},{"cnt":[[245,1796],[1854,1796],[1854,1843],[245,1843]],"region":{"top_left_x":244,"top_left_y":1796,"width":1611,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d15b97d8258c41fc9588af8bb44bbc89","type":"text","conversion_output":true,"text":"treatment fidelity data will provide information on the adherence of the PTs to the interventions,","text_display":" treatment fidelity data will provide information on the adherence of the PTs to the interventions,","confidence":1,"confidence_rate":1},{"cnt":[[245,1839],[1843,1839],[1843,1886],[245,1886]],"region":{"top_left_x":244,"top_left_y":1839,"width":1600,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fb2a52573e047ddb00b4ac078a49504","type":"text","conversion_output":true,"text":"and the adherence of the participants to the prescribed activities. Monitoring treatment fidelity","text_display":" and the adherence of the participants to the prescribed activities. Monitoring treatment fidelity","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1768,1882],[1768,1931],[245,1931]],"region":{"top_left_x":244,"top_left_y":1882,"width":1525,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31ba9ecc762448a7b27c8c948907e54f","type":"text","conversion_output":true,"text":"also will provide an opportunity to address potential study problems, such as drift from the","text_display":" also will provide an opportunity to address potential study problems, such as drift from the","confidence":1,"confidence_rate":1},{"cnt":[[245,1927],[1815,1927],[1815,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1927,"width":1572,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ebc3671086d42d4949bbfb6b76d7067","type":"text","conversion_output":true,"text":"intervention protocols which could threaten the study's ability to detect treatment differences.","text_display":" intervention protocols which could threaten the study's ability to detect treatment differences.","confidence":1,"confidence_rate":1},{"cnt":[[365,2011],[1233,2011],[1233,2065],[365,2065]],"region":{"top_left_x":365,"top_left_y":2010,"width":869,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa1dce01abeb46268a3aa73283488697","type":"section_header","conversion_output":false,"children_ids":["dfb450b3809c49c7a1f960df5bc8a079"],"text":"","text_display":""},{"cnt":[[370,2015],[1229,2015],[1229,2060],[370,2060]],"region":{"top_left_x":369,"top_left_y":2015,"width":860,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfb450b3809c49c7a1f960df5bc8a079","type":"text","conversion_output":true,"parent_id":"aa1dce01abeb46268a3aa73283488697","text":"9.5.1 Initial Training for Procedural Reliability","text_display":"\n\n\\subsection*{9.5.1 Initial Training for Procedural Reliability}","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1833,2058],[1833,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":1589,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93b521e13c6444f78d3f60c5973880e2","type":"text","conversion_output":true,"text":"The Intervention Monitor (IM) will train PTs in either PUSH intervention or PULSE intervention","text_display":"\n\nThe Intervention Monitor (IM) will train PTs in either PUSH intervention or PULSE intervention","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1811,2105],[1811,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2105,"width":1568,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"380edc5ec8db4c39a24942c3a95ef1e8","type":"text","conversion_output":true,"text":"procedures. In order to minimize crossover, the PTs will only be trained on one intervention.","text_display":" procedures. In order to minimize crossover, the PTs will only be trained on one intervention.","confidence":1,"confidence_rate":1},{"cnt":[[245,2148],[1790,2148],[1790,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2148,"width":1546,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e173a05f80d431ba4b90ca2978a1e0f","type":"text","conversion_output":true,"text":"There will be separate training sessions for each intervention and the PTs will not know the","text_display":" There will be separate training sessions for each intervention and the PTs will not know the","confidence":1,"confidence_rate":1},{"cnt":[[245,2191],[786,2191],[786,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2191,"width":543,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc7d9fed241b4638a468ce95faa5d313","type":"text","conversion_output":true,"text":"details of the other intervention.","text_display":" details of the other intervention.","confidence":1,"confidence_rate":1},{"cnt":[[245,2282],[1755,2282],[1755,2327],[245,2327]],"region":{"top_left_x":244,"top_left_y":2281,"width":1512,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bc517eee7304f4a9acd1ae0b03b39b9","type":"text","conversion_output":true,"text":"Knowledge of procedures will be tested by written examination and by psychomotor skills","text_display":"\n\nKnowledge of procedures will be tested by written examination and by psychomotor skills","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,2322],[1807,2322],[1807,2370],[245,2370]],"region":{"top_left_x":244,"top_left_y":2322,"width":1563,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c7d558fcc124098bbb5fb24c704c08d","type":"text","conversion_output":true,"text":"observation via video. The IM will document that PTs are \"CAP certified PTs\" and provide a","text_display":" observation via video. The IM will document that PTs are \"CAP certified PTs\" and provide a","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1790,2368],[1790,2415],[245,2415]],"region":{"top_left_x":244,"top_left_y":2367,"width":1546,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f710662037144a68345fe39a3e1536d","type":"text","conversion_output":true,"text":"certificate of completion after they demonstrate competence on the written exam and video","text_display":" certificate of completion after they demonstrate competence on the written exam and video","confidence":1,"confidence_rate":1},{"cnt":[[245,2411],[1792,2411],[1792,2460],[245,2460]],"region":{"top_left_x":244,"top_left_y":2410,"width":1548,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04a289511c464934a6f976de22de315d","type":"text","conversion_output":true,"text":"observation. PTs also need to bring evidence to the training session that they are currently","text_display":" observation. PTs also need to bring evidence to the training session that they are currently","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bc58bab4e3c4a50aefa82e1dfbc2157","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1833,2587],[1882,2587],[1882,2625],[1833,2625]],"region":{"top_left_x":1832,"top_left_y":2586,"width":51,"height":40},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0092777c63b74b56b22d6a8c719354df","type":"page_info","conversion_output":false,"text":"29","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-049","page":49,"lines":[{"cnt":[[245,249],[1835,249],[1835,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1591,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2578bd12b5f4a528c41e2cd63e2aea1","type":"text","conversion_output":true,"text":"CPR certified. As new PTs join the study, training will be conducted on an individualized basis","text_display":"\n\nCPR certified. 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The approaches","text_display":"\n\nWe will use a multi-faceted approach to ensure ongoing treatment fidelity. The approaches","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,473],[1878,473],[1878,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1634,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2d74f8f930b4126ad79839a6dfe0ebe","type":"text","conversion_output":true,"text":"include direct observation of skills by the clinical site coordinators, mandatory monthly telephone","text_display":" include direct observation of skills by the clinical site coordinators, mandatory monthly telephone","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1820,516],[1820,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1576,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0b20ce181e048c69a698e4553a4f45c","type":"text","conversion_output":true,"text":"calls with all active PTs, periodic review of PT log books, access to online discussion boards,","text_display":" calls with all active PTs, periodic review of PT log books, access to online discussion boards,","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1532,559],[1532,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1288,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0080835e15444e8bb328420601ed0fb8","type":"text","conversion_output":true,"text":"and face-to-face meetings with the intervention team at least twice per year.","text_display":" and face-to-face meetings with the intervention team at least twice per year.","confidence":1,"confidence_rate":1},{"cnt":[[305,645],[1785,645],[1785,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1481,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5f94404014944c7be4452b967d60416","type":"text","conversion_output":true,"text":"Direct Observation: Direct observations of PTs as they perform the interventions will be","text_display":"\n\nDirect Observation: Direct observations of PTs as they perform the interventions will be","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[305,692],[1869,692],[1869,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":1565,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3440863552e94bc08aa31a39e6c95ade","type":"text","conversion_output":true,"text":"conducted by the clinical site coordinators who will be trained on both intervention protocols.","text_display":" conducted by the clinical site coordinators who will be trained on both intervention protocols.","confidence":1,"confidence_rate":1},{"cnt":[[305,735],[1704,735],[1704,780],[305,780]],"region":{"top_left_x":305,"top_left_y":734,"width":1399,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74ec8370a92e4827a92aec164e541caf","type":"text","conversion_output":true,"text":"The coordinators will document their observations using a structured checklist that","text_display":" The coordinators will document their observations using a structured checklist that","confidence":1,"confidence_rate":1},{"cnt":[[305,778],[1828,778],[1828,827],[305,827]],"region":{"top_left_x":305,"top_left_y":777,"width":1524,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"580364ec59f14907957e1906996e44a8","type":"text","conversion_output":true,"text":"addresses data completeness, physical performance, qualitative observations, and verbal","text_display":" addresses data completeness, physical performance, qualitative observations, and verbal","confidence":1,"confidence_rate":1},{"cnt":[[305,821],[1764,821],[1764,870],[305,870]],"region":{"top_left_x":305,"top_left_y":820,"width":1459,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc04ffae33d14c8188f9f25ce05253dc","type":"text","conversion_output":true,"text":"and non-verbal communication. In the PUSH intervention group, the checklist will also","text_display":" and non-verbal communication. In the PUSH intervention group, the checklist will also","confidence":1,"confidence_rate":1},{"cnt":[[305,868],[1815,868],[1815,913],[305,913]],"region":{"top_left_x":305,"top_left_y":867,"width":1511,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac78aef5b9ce44b591d2f732ec196236","type":"text","conversion_output":true,"text":"document whether the participant completed the necessary repetitions at the appropriate","text_display":" document whether the participant completed the necessary repetitions at the appropriate","confidence":1,"confidence_rate":1},{"cnt":[[305,911],[1871,911],[1871,956],[305,956]],"region":{"top_left_x":305,"top_left_y":910,"width":1567,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8a6885bbbe243a1add811a5c20dedcf","type":"text","conversion_output":true,"text":"intensity and whether the participant completed 20 minutes of aerobic exercise at the proper","text_display":" intensity and whether the participant completed 20 minutes of aerobic exercise at the proper","confidence":1,"confidence_rate":1},{"cnt":[[305,954],[1858,954],[1858,1001],[305,1001]],"region":{"top_left_x":305,"top_left_y":953,"width":1554,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e75521e9b5844cfabdf4e97af43768b7","type":"text","conversion_output":true,"text":"intensity. The checklist for the PULSE intervention group will document that the participants","text_display":" intensity. 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There will be two","text_display":" TENS at the appropriate level and for the proper amount of time. There will be two","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[305,1087],[1807,1087],[1807,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1087,"width":1502,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fe29752b5ab467d964a8bd4d3e6833b","type":"text","conversion_output":true,"text":"observation visits during the PT's first assigned participant's 16-week intervention period","text_display":" observation visits during the PT's first assigned participant's 16-week intervention period","confidence":0.5078125,"confidence_rate":0.9929660734925442},{"cnt":[[305,1130],[1794,1130],[1794,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":1489,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0b6ccb3ed2045608b7fe46741aff427","type":"text","conversion_output":true,"text":"and then one observation per quarter for PTs who have conducted a complete 16 -week","text_display":" and then one observation per quarter for PTs who have conducted a complete 16 -week","confidence":0.5888671875,"confidence_rate":0.9941976178055888},{"cnt":[[305,1173],[1850,1173],[1850,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":1545,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55aceac4bf5749528f0b820fc6bb878c","type":"text","conversion_output":true,"text":"intervention period for at least one participant. If the total score on the checklist is less than","text_display":" intervention period for at least one participant. If the total score on the checklist is less than","confidence":1,"confidence_rate":1},{"cnt":[[305,1216],[1850,1216],[1850,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":1545,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"276f1a5437e042dc857eaeb110106133","type":"text","conversion_output":true,"text":"\\(90 \\%\\), the IM and clinical site PI will be notified. A remediation plan will be proposed that will","text_display":" \\(90 \\%\\), the IM and clinical site PI will be notified. A remediation plan will be proposed that will","confidence":1,"confidence_rate":1},{"cnt":[[305,1263],[1699,1263],[1699,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1263,"width":1395,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c9333efee2a4fe59f34cf4992abdab3","type":"text","conversion_output":true,"text":"offer refresher training to ensure accurate understanding of the protocol, follow-up","text_display":" offer refresher training to ensure accurate understanding of the protocol, follow-up","confidence":1,"confidence_rate":1},{"cnt":[[305,1306],[1231,1306],[1231,1351],[305,1351]],"region":{"top_left_x":305,"top_left_y":1306,"width":927,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa5d9822b90b4b67a83a9385d0ea83c9","type":"text","conversion_output":true,"text":"observation visits, and possible dismissal if warranted.","text_display":" observation visits, and possible dismissal if warranted.","confidence":1,"confidence_rate":1},{"cnt":[[305,1392],[1858,1392],[1858,1439],[305,1439]],"region":{"top_left_x":305,"top_left_y":1392,"width":1554,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31cd3c6523aa4be9acc2e7c3a5ec8654","type":"text","conversion_output":true,"text":"Mandatory Conference Calls with PTs: The IM will conduct monthly telephone calls with the","text_display":"\n\nMandatory Conference Calls with PTs: The IM will conduct monthly telephone calls with the","confidence":1,"confidence_rate":1},{"cnt":[[305,1437],[1794,1437],[1794,1485],[305,1485]],"region":{"top_left_x":305,"top_left_y":1437,"width":1489,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c909fcb78933441c8046d876b5a906b7","type":"text","conversion_output":true,"text":"PTs who are currently active with participants. The Treatment Fidelity Manager will take","text_display":" PTs who are currently active with participants. The Treatment Fidelity Manager will take","confidence":1,"confidence_rate":1},{"cnt":[[305,1482],[1850,1482],[1850,1528],[305,1528]],"region":{"top_left_x":305,"top_left_y":1482,"width":1545,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65fa5af38abd4ecba21c2978063402a1","type":"text","conversion_output":true,"text":"minutes of the telephone meetings to document ongoing training. During these calls (which","text_display":" minutes of the telephone meetings to document ongoing training. During these calls (which","confidence":1,"confidence_rate":1},{"cnt":[[305,1525],[1828,1525],[1828,1573],[305,1573]],"region":{"top_left_x":305,"top_left_y":1525,"width":1524,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"352885cf89bf484b9ff6ae065aba3edc","type":"text","conversion_output":true,"text":"will be done separately for the PTs in the two groups), the IM will ask questions to identify","text_display":" will be done separately for the PTs in the two groups), the IM will ask questions to identify","confidence":1,"confidence_rate":1},{"cnt":[[305,1571],[1846,1571],[1846,1618],[305,1618]],"region":{"top_left_x":305,"top_left_y":1570,"width":1541,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d757869edd5c47e3a23dc497d3fe0193","type":"text","conversion_output":true,"text":"problems with delivering the intervention. If problems are identified, the IM will schedule an","text_display":" problems with delivering the intervention. If problems are identified, the IM will schedule an","confidence":1,"confidence_rate":1},{"cnt":[[305,1611],[1876,1611],[1876,1661],[305,1661]],"region":{"top_left_x":305,"top_left_y":1611,"width":1571,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b446e4d896e47a7b74f932f7028b320","type":"text","conversion_output":true,"text":"individual telephone call and review of PT log books. Additional follow-up will be mandated if","text_display":" individual telephone call and review of PT log books. Additional follow-up will be mandated if","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[305,1659],[1869,1659],[1869,1704],[305,1704]],"region":{"top_left_x":305,"top_left_y":1658,"width":1565,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c780a8d48b040b18afed08d096f4a6f","type":"text","conversion_output":true,"text":"there are modifications to the exercise prescription that are due to PT factors. A remediation","text_display":" there are modifications to the exercise prescription that are due to PT factors. A remediation","confidence":0.72802734375,"confidence_rate":0.9969815487936854},{"cnt":[[305,1702],[1257,1702],[1257,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1701,"width":952,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7283041c00b427d81de86ecb8e2dd07","type":"text","conversion_output":true,"text":"plan will be followed if there is ongoing lack of progress.","text_display":" plan will be followed if there is ongoing lack of progress.","confidence":1,"confidence_rate":1},{"cnt":[[305,1788],[1824,1788],[1824,1835],[305,1835]],"region":{"top_left_x":305,"top_left_y":1787,"width":1520,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9006b7f1d2684ab1a56a3c8c81207cc8","type":"text","conversion_output":true,"text":"Periodic Review of Intervention Logs: Clinical site coordinators will review PT intervention","text_display":"\n\nPeriodic Review of Intervention Logs: Clinical site coordinators will review PT intervention","confidence":1,"confidence_rate":1},{"cnt":[[305,1833],[1749,1833],[1749,1880],[305,1880]],"region":{"top_left_x":305,"top_left_y":1832,"width":1444,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4ce2506335c4369a5377d5c13f43260","type":"text","conversion_output":true,"text":"logs when the PTs come to the study office to pick up study medications or to submit","text_display":" logs when the PTs come to the study office to pick up study medications or to submit","confidence":1,"confidence_rate":1},{"cnt":[[305,1878],[1755,1878],[1755,1923],[305,1923]],"region":{"top_left_x":305,"top_left_y":1877,"width":1451,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f63548afabee422da3ef77bd45ec005c","type":"text","conversion_output":true,"text":"completed forms. The coordinator will note if PTs are completing logs and if there are","text_display":" completed forms. The coordinator will note if PTs are completing logs and if there are","confidence":1,"confidence_rate":1},{"cnt":[[305,1921],[1729,1921],[1729,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1920,"width":1425,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8442ec22d144999b93fc7087644c697","type":"text","conversion_output":true,"text":"modifications to the intervention protocols. This information will be sent to the IM for","text_display":" modifications to the intervention protocols. This information will be sent to the IM for","confidence":0.9970703125,"confidence_rate":0.9999684522456539},{"cnt":[[305,1964],[1033,1964],[1033,2013],[305,2013]],"region":{"top_left_x":305,"top_left_y":1963,"width":729,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e848ba6242264158b32328d5838caaf6","type":"text","conversion_output":true,"text":"discussion during the monthly phone calls.","text_display":" discussion during the monthly phone calls.","confidence":1,"confidence_rate":1},{"cnt":[[305,2052],[1725,2052],[1725,2099],[305,2099]],"region":{"top_left_x":305,"top_left_y":2051,"width":1421,"height":49},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4daebf973d41406daea5f1cd04066bbf","type":"text","conversion_output":true,"text":"IM Site Visits: The IM will visit each site semi-annually to meet with all the PTs, with","text_display":"\n\nIM Site Visits: The IM will visit each site semi-annually to meet with all the PTs, with","confidence":1,"confidence_rate":1},{"cnt":[[305,2097],[1876,2097],[1876,2142],[305,2142]],"region":{"top_left_x":305,"top_left_y":2096,"width":1571,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46384d80e42340b4a54c85f74b0712f6","type":"text","conversion_output":true,"text":"separate meetings for each intervention group. This will be a team building visit emphasizing","text_display":" separate meetings for each intervention group. This will be a team building visit emphasizing","confidence":0.998046875,"confidence_rate":0.9999800508639274},{"cnt":[[305,2140],[1588,2140],[1588,2189],[305,2189]],"region":{"top_left_x":305,"top_left_y":2139,"width":1283,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69d6c4110bf5452aabfcf89ca774327f","type":"text","conversion_output":true,"text":"proper delivery of the intervention and discussing issues specific to the site.","text_display":" proper delivery of the intervention and discussing issues specific to the site.","confidence":1,"confidence_rate":1},{"cnt":[[365,2224],[1124,2224],[1124,2277],[365,2277]],"region":{"top_left_x":365,"top_left_y":2223,"width":759,"height":55},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7b2dc63f0b5472abdcb3bc43398e1ed","type":"section_header","conversion_output":false,"children_ids":["0aff837c24b447a0ae9c038c16e23008"],"text":"","text_display":""},{"cnt":[[370,2228],[1119,2228],[1119,2273],[370,2273]],"region":{"top_left_x":369,"top_left_y":2227,"width":751,"height":47},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0aff837c24b447a0ae9c038c16e23008","type":"text","conversion_output":true,"parent_id":"d7b2dc63f0b5472abdcb3bc43398e1ed","text":"9.5.3 Monitoring Physiologic Response","text_display":"\n\n\\subsection*{9.5.3 Monitoring Physiologic Response}","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1841,2273],[1841,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1598,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e773bfecf0c745ae89ade2c88423a2d6","type":"text","conversion_output":true,"text":"As a measure of treatment fidelity, we will monitor physiologic response (heart rate) during the","text_display":"\n\nAs a measure of treatment fidelity, we will monitor physiologic response (heart rate) during the","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1697,2316],[1697,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":1454,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"912c97751adb410287b0f32dd5bd8c8b","type":"text","conversion_output":true,"text":"intervention sessions using Polar heart rate monitors. The monitors will be worn by all","text_display":" intervention sessions using Polar heart rate monitors. The monitors will be worn by all","confidence":1,"confidence_rate":1},{"cnt":[[245,2359],[1815,2359],[1815,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2358,"width":1572,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cee9d99d9ea452dab5ffee2a7365e1e","type":"text","conversion_output":true,"text":"participants at all intervention sessions. The Polar monitor allows the operator to indicate the","text_display":" participants at all intervention sessions. The Polar monitor allows the operator to indicate the","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,2402],[1813,2402],[1813,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1570,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"340d5c8eb47b4fd1a5608f272607e7ea","type":"text","conversion_output":true,"text":"start and end of distinct time segments referred to as \"laps\" by the device's software system.","text_display":" start and end of distinct time segments referred to as \"laps\" by the device's software system.","confidence":1,"confidence_rate":1},{"cnt":[[245,2447],[1416,2447],[1416,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2447,"width":1172,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f63021cf151f4d86aed48478fc770ed9","type":"text","conversion_output":true,"text":"Each intervention session will consist of four laps, defined as follows:","text_display":" Each intervention session will consist of four laps, defined as follows:","confidence":0.99755859375,"confidence_rate":0.999968255161777},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8790e6529134cad9151ed27c08a5c08","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b00adade97ba420d8d18985e3bf63a1d","type":"page_info","conversion_output":false,"text":"30","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-050","page":50,"lines":[{"cnt":[[223,288],[1899,288],[1899,526],[223,526]],"region":{"top_left_x":223,"top_left_y":287,"width":1677,"height":240},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c20e34359fd4818bbb2b3f8a869f34e","type":"table","conversion_output":true,"text":"\\begin{tabular}{|c|l|l|}\n\\hline Lap & \\multicolumn{1}{|c|}{ PUSH Intervention } & \\multicolumn{1}{c|}{ PULSE Intervention } \\\\\n\\hline 1 & Greeting, health questions, BP, HR & Greeting, health questions, BP, HR \\\\\n\\hline 2 & Strength training, BP, HR & AROM training, BP, HR \\\\\n\\hline 3 & Endurance training & TENS \\\\\n\\hline 4 & Wrap-up & Wrap-up \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|c|l|l|}\n\\hline Lap & \\multicolumn{1}{|c|}{ PUSH Intervention } & \\multicolumn{1}{c|}{ PULSE Intervention } \\\\\n\\hline 1 & Greeting, health questions, BP, HR & Greeting, health questions, BP, HR \\\\\n\\hline 2 & Strength training, BP, HR & AROM training, BP, HR \\\\\n\\hline 3 & Endurance training & TENS \\\\\n\\hline 4 & Wrap-up & Wrap-up \\\\\n\\hline\n\\end{tabular}","confidence":0.9980475902557373,"confidence_rate":0.9999940417306146},{"cnt":[[245,524],[1783,524],[1783,574],[245,574]],"region":{"top_left_x":244,"top_left_y":524,"width":1540,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b22953c991dc46fa8308125035de5291","type":"text","conversion_output":true,"text":"\\(BP =\\) blood pressure; HR=heart rate; AROM=active range of motion; TENS=transcutaneous","text_display":"\n\\(BP =\\) blood pressure; HR=heart rate; AROM=active range of motion; TENS=transcutaneous","confidence":0.4955486043825281,"confidence_rate":0.9922293506133788},{"cnt":[[245,571],[711,571],[711,612],[245,612]],"region":{"top_left_x":244,"top_left_y":571,"width":468,"height":42},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4a341f2967447dbb44ffe5e59cae3e9","type":"text","conversion_output":true,"text":"electrical nerve stimulation.","text_display":" electrical nerve stimulation.","confidence":1,"confidence_rate":1},{"cnt":[[245,657],[1869,657],[1869,707],[245,707]],"region":{"top_left_x":244,"top_left_y":657,"width":1626,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5568ae6c4efe4ceb9161103a5cf97d59","type":"text","conversion_output":true,"text":"The Polar monitoring will provide a dichotomous variable reflecting whether, during laps 2 and 3","text_display":"\n\nThe Polar monitoring will provide a dichotomous variable reflecting whether, during laps 2 and 3","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1824,700],[1824,750],[245,750]],"region":{"top_left_x":244,"top_left_y":700,"width":1581,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfbfd26673f645499d2d045dec47f002","type":"text","conversion_output":true,"text":"of each intervention session, the participant's average HR was equal to or greater than his or","text_display":" of each intervention session, the participant's average HR was equal to or greater than his or","confidence":0.6650390625,"confidence_rate":0.9958881788071716},{"cnt":[[245,743],[1811,743],[1811,793],[245,793]],"region":{"top_left_x":244,"top_left_y":743,"width":1568,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8e956fb8b564262901830b7779bb5d6","type":"text","conversion_output":true,"text":"her target heart rate ( \\(\\pm 5\\) beats). The target heart rate is defined as 50\\% of heart rate reserve","text_display":" her target heart rate ( \\(\\pm 5\\) beats). The target heart rate is defined as 50\\% of heart rate reserve","confidence":0.6068229675292969,"confidence_rate":0.9952084568027921},{"cnt":[[245,786],[728,786],[728,831],[245,831]],"region":{"top_left_x":244,"top_left_y":786,"width":485,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93e9fc9abc264e9593969c880296f287","type":"text","conversion_output":true,"text":"and is calculated as follows:","text_display":" and is calculated as follows:","confidence":1,"confidence_rate":1},{"cnt":[[245,877],[1506,877],[1506,926],[245,926]],"region":{"top_left_x":244,"top_left_y":876,"width":1263,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f1757f9dcbf47c38a1d4fff75499838","type":"text","conversion_output":true,"text":"Target \\(HR =\\left(((220-\\text { age })- RHR )^{*} 0.5\\right)+ RHR\\), where \\(RHR =\\) resting heart rate.","text_display":"\n\nTarget \\(HR =\\left(((220-\\text { age })- RHR )^{*} 0.5\\right)+ RHR\\), where \\(RHR =\\) resting heart rate.","confidence":0.4891700622248207,"confidence_rate":0.9930818561134752},{"cnt":[[245,962],[1852,962],[1852,1012],[245,1012]],"region":{"top_left_x":244,"top_left_y":962,"width":1608,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bca6a3fad8146d3abed84e420250747","type":"text","conversion_output":true,"text":"In addition, the IM will perform ongoing qualitative reviews of the HR curves that are generated","text_display":"\nIn addition, the IM will perform ongoing qualitative reviews of the HR curves that are generated","confidence":0.921875,"confidence_rate":0.999194921878602},{"cnt":[[245,1008],[1869,1008],[1869,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1007,"width":1626,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbbd30c568e847dd845e1d8002bc3677","type":"text","conversion_output":true,"text":"by the software. She will examine the duration of the laps as well as the pattern of activity within","text_display":" by the software. She will examine the duration of the laps as well as the pattern of activity within","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1848,1053],[1848,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1052,"width":1604,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a9961806c514b5996b15f88ed170322","type":"text","conversion_output":true,"text":"the laps (height of curve, duration of the rise in HR, number of times HR rises within a lap) and","text_display":" the laps (height of curve, duration of the rise in HR, number of times HR rises within a lap) and","confidence":0.9990234375,"confidence_rate":0.9999904212258001},{"cnt":[[245,1096],[1803,1096],[1803,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1095,"width":1559,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0070856958174c97a661ff72026169f6","type":"text","conversion_output":true,"text":"compare them to pre-specified criteria established for each intervention. If the pattern of HR","text_display":" compare them to pre-specified criteria established for each intervention. If the pattern of HR","confidence":0.7724609375,"confidence_rate":0.9973955808559007},{"cnt":[[245,1139],[1869,1139],[1869,1188],[245,1188]],"region":{"top_left_x":244,"top_left_y":1138,"width":1626,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f0068f82b6149de9680c83eeab6e6db","type":"text","conversion_output":true,"text":"curves deviates from the pre-established expectations, she will confer with the PT regarding the","text_display":" curves deviates from the pre-established expectations, she will confer with the PT regarding the","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1182],[1384,1182],[1384,1233],[245,1233]],"region":{"top_left_x":244,"top_left_y":1181,"width":1140,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bff9d5b7d12a4cfd8ea6fa65778151f2","type":"text","conversion_output":true,"text":"possible reasons and implement appropriate actions as necessary.","text_display":" possible reasons and implement appropriate actions as necessary.","confidence":0.99951171875,"confidence_rate":0.9999929217569623},{"cnt":[[271,1272],[982,1272],[982,1330],[271,1330]],"region":{"top_left_x":270,"top_left_y":1271,"width":712,"height":59},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c524a7e522244344beba0e8d242beed8","type":"section_header","conversion_output":false,"children_ids":["e507c71670b94345ab324136898ff072"],"text":"","text_display":""},{"cnt":[[275,1276],[978,1276],[978,1326],[275,1326]],"region":{"top_left_x":275,"top_left_y":1276,"width":703,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e507c71670b94345ab324136898ff072","type":"text","conversion_output":true,"parent_id":"c524a7e522244344beba0e8d242beed8","text":"9.6 Scheduling Intervention Visits","text_display":"\n\n\\subsection*{9.6 Scheduling Intervention Visits}","confidence":1,"confidence_rate":1},{"cnt":[[245,1323],[1356,1323],[1356,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1323,"width":1112,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7898b079d3f643f1b1667bc1e620b39b","type":"text","conversion_output":true,"text":"There are three requirements for scheduling of intervention visits:","text_display":"\n\nThere are three requirements for scheduling of intervention visits:","confidence":1,"confidence_rate":1},{"cnt":[[245,1366],[1858,1366],[1858,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1366,"width":1615,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99076524ad9a44649fe65050feeffe41","type":"text","conversion_output":true,"text":"1. The first intervention visit should occur on Day 7 or earlier, where the day of randomization \\(=\\)","text_display":"\n1. The first intervention visit should occur on Day 7 or earlier, where the day of randomization \\(=\\)","confidence":0.99462890625,"confidence_rate":0.999948710173153},{"cnt":[[288,1414],[406,1414],[406,1459],[288,1459]],"region":{"top_left_x":287,"top_left_y":1413,"width":120,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7bd6881cadc4f04ab501414e0f22054","type":"text","conversion_output":true,"text":"Day 0.","text_display":" Day 0.","confidence":0.98828125,"confidence_rate":0.9988218989313793},{"cnt":[[245,1454],[1800,1454],[1800,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1454,"width":1557,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"715b5ffa151c437ea9af88a063cd829c","type":"text","conversion_output":true,"text":"2. The schedule of intervention visits is anchored to the date of randomization regardless of","text_display":"\n2. The schedule of intervention visits is anchored to the date of randomization regardless of","confidence":1,"confidence_rate":1},{"cnt":[[284,1500],[776,1500],[776,1545],[284,1545]],"region":{"top_left_x":283,"top_left_y":1499,"width":493,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8683cc12e5f407c9b0b186f5cf3276b","type":"text","conversion_output":true,"text":"when the intervention starts.","text_display":" when the intervention starts.","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1854,1543],[1854,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1542,"width":1611,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6501e0f1cc434609a97d63034d12a261","type":"text","conversion_output":true,"text":"3. Intervention visits should never occur on two consecutive days, even when moving from one","text_display":"\n3. Intervention visits should never occur on two consecutive days, even when moving from one","confidence":1,"confidence_rate":1},{"cnt":[[284,1590],[587,1590],[587,1631],[284,1631]],"region":{"top_left_x":283,"top_left_y":1589,"width":304,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30c1e3c2e6584c9ca0b3188978b89222","type":"text","conversion_output":true,"text":"week to the next.","text_display":" week to the next.","confidence":1,"confidence_rate":1},{"cnt":[[245,1674],[1846,1674],[1846,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1673,"width":1602,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bccb3e61e406427e9837e27e2be3be32","type":"text","conversion_output":true,"text":"For all randomized participants, Week 1 will begin on the day of the first intervention visit or on","text_display":"\n\nFor all randomized participants, Week 1 will begin on the day of the first intervention visit or on","confidence":1,"confidence_rate":1},{"cnt":[[245,1719],[1880,1719],[1880,1766],[245,1766]],"region":{"top_left_x":244,"top_left_y":1718,"width":1636,"height":49},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7956a68a7725467487152a9ac3a40cd2","type":"text","conversion_output":true,"text":"Day 7 post-randomization, whichever is earlier. Subsequent weeks will start on the same day of","text_display":" Day 7 post-randomization, whichever is earlier. Subsequent weeks will start on the same day of","confidence":1,"confidence_rate":1},{"cnt":[[245,1762],[1854,1762],[1854,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1761,"width":1611,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e7a8cf98f49427ca08c77ee415bb68b","type":"text","conversion_output":true,"text":"the week as Week 1. For example, if the participant's first intervention visit is on a Wednesday,","text_display":" the week as Week 1. For example, if the participant's first intervention visit is on a Wednesday,","confidence":1,"confidence_rate":1},{"cnt":[[245,1807],[1869,1807],[1869,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1806,"width":1626,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b8788e27cbc4e97bf254b0df4d7de0b","type":"text","conversion_output":true,"text":"each intervention week for that participant will extend from Wednesday to Tuesday (inclusively).","text_display":" each intervention week for that participant will extend from Wednesday to Tuesday (inclusively).","confidence":1,"confidence_rate":1},{"cnt":[[245,1852],[1796,1852],[1796,1899],[245,1899]],"region":{"top_left_x":244,"top_left_y":1851,"width":1553,"height":49},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0a8f9e6d8dc49768fb059bb80e01554","type":"text","conversion_output":true,"text":"Alternatively, if the first visit has not yet occurred by Day 7 and Day 7 is a Monday, then the","text_display":" Alternatively, if the first visit has not yet occurred by Day 7 and Day 7 is a Monday, then the","confidence":0.99853515625,"confidence_rate":0.9999861706835268},{"cnt":[[245,1895],[1609,1895],[1609,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1894,"width":1366,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2aad0874388c4ea2baca9675b18aab05","type":"text","conversion_output":true,"text":"participant's intervention weeks will extend from Monday to Sunday (inclusively).","text_display":" participant's intervention weeks will extend from Monday to Sunday (inclusively).","confidence":1,"confidence_rate":1},{"cnt":[[245,1981],[1850,1981],[1850,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1980,"width":1606,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"145c15a21c03410292420a88ea999a12","type":"text","conversion_output":true,"text":"In certain circumstances (e.g., illness, travel), the first intervention visit may be scheduled after","text_display":"\n\nIn certain circumstances (e.g., illness, travel), the first intervention visit may be scheduled after","confidence":1,"confidence_rate":1},{"cnt":[[245,2024],[363,2024],[363,2073],[245,2073]],"region":{"top_left_x":244,"top_left_y":2023,"width":120,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa8756a28ac14ac09ee32b6913af9e60","type":"text","conversion_output":true,"text":"Day 7.","text_display":" Day 7.","confidence":1,"confidence_rate":1},{"cnt":[[245,2114],[1785,2114],[1785,2161],[245,2161]],"region":{"top_left_x":244,"top_left_y":2114,"width":1542,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2b3a3e4e84643d1bc962c21ea0ebb81","type":"text","conversion_output":true,"text":"Ideally participants will receive 2 visits per week for 16 weeks post-randomization ( 32 visits","text_display":"\n\nIdeally participants will receive 2 visits per week for 16 weeks post-randomization ( 32 visits","confidence":0.9970724582672119,"confidence_rate":0.9999731027895805},{"cnt":[[245,2157],[1850,2157],[1850,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2157,"width":1606,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"474e6523fc4343f2bcd2eecc4cad0ae5","type":"text","conversion_output":true,"text":"total). However, missed visits in a given week can be replaced by makeup visits in subsequent","text_display":" total). However, missed visits in a given week can be replaced by makeup visits in subsequent","confidence":1,"confidence_rate":1},{"cnt":[[245,2202],[1824,2202],[1824,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2202,"width":1581,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2a6fd12059d409fbd148edb4526cc82","type":"text","conversion_output":true,"text":"weeks (not to exceed 3 visits in any given week) as long as the visits are on non-consecutive","text_display":" weeks (not to exceed 3 visits in any given week) as long as the visits are on non-consecutive","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,2247],[1772,2247],[1772,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2247,"width":1529,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5510e36bb0ab4dc3a2ea04d0ebe8960f","type":"text","conversion_output":true,"text":"days. If the participant has not had 32 visits by the end of 16 weeks, makeup visits can be","text_display":" days. If the participant has not had 32 visits by the end of 16 weeks, makeup visits can be","confidence":0.99853515625,"confidence_rate":0.9999856283612877},{"cnt":[[245,2290],[1777,2290],[1777,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2290,"width":1533,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"247dcd77d1de42c797086c375c1201f7","type":"text","conversion_output":true,"text":"performed during the subsequent two weeks to get as close as possible to the target of 32","text_display":" performed during the subsequent two weeks to get as close as possible to the target of 32","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,2333],[350,2333],[350,2378],[245,2378]],"region":{"top_left_x":244,"top_left_y":2333,"width":107,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88076e5981f94e0792700552d31e6aa5","type":"text","conversion_output":true,"text":"visits.","text_display":" visits.","confidence":0.99951171875,"confidence_rate":0.9999593007867263},{"cnt":[[245,2587],[662,2587],[662,2625],[245,2625]],"region":{"top_left_x":244,"top_left_y":2586,"width":418,"height":40},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a73eb2f403b945d6a6f70d052085363b","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1833,2587],[1886,2587],[1886,2628],[1833,2628]],"region":{"top_left_x":1832,"top_left_y":2586,"width":55,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f730eea2cb7446e7bac873427e047758","type":"page_info","conversion_output":false,"text":"31","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-051","page":51,"lines":[{"cnt":[[243,249],[913,249],[913,314],[243,314]],"region":{"top_left_x":242,"top_left_y":249,"width":672,"height":65},"line":1,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"4b135fe8230c46b1afecbf7e67820499","type":"section_header","conversion_output":false,"children_ids":["f75df46d590e43cfb4e8462408046358"],"text":"","text_display":""},{"cnt":[[245,254],[909,254],[909,312],[245,312]],"region":{"top_left_x":244,"top_left_y":253,"width":665,"height":59},"line":2,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"f75df46d590e43cfb4e8462408046358","type":"text","conversion_output":true,"parent_id":"4b135fe8230c46b1afecbf7e67820499","text":"Section 10: Study Measures","text_display":"\n\n\\section*{Section 10: Study Measures}","confidence":1,"confidence_rate":1},{"cnt":[[245,329],[1869,329],[1869,376],[245,376]],"region":{"top_left_x":244,"top_left_y":328,"width":1626,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"893d144df21344aca868e4ab7bd23692","type":"text","conversion_output":true,"text":"A list of study measures is provided below. All of the measures will be interview-based or based","text_display":"\n\nA list of study measures is provided below. All of the measures will be interview-based or based","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,372],[1858,372],[1858,419],[245,419]],"region":{"top_left_x":244,"top_left_y":371,"width":1615,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d9d27975f7b443e9fffcee40df3ba81","type":"text","conversion_output":true,"text":"on observations of performance or physiological assessments. No proxy data will be allowed at","text_display":" on observations of performance or physiological assessments. No proxy data will be allowed at","confidence":1,"confidence_rate":1},{"cnt":[[245,417],[1717,417],[1717,462],[245,462]],"region":{"top_left_x":244,"top_left_y":416,"width":1473,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12c50fe49112426cbfe31197eb8f12ee","type":"text","conversion_output":true,"text":"baseline. However, at the 16 -week follow-up visit, a proxy may be contacted to provide","text_display":" baseline. However, at the 16 -week follow-up visit, a proxy may be contacted to provide","confidence":0.95263671875,"confidence_rate":0.999489376249164},{"cnt":[[245,460],[1811,460],[1811,505],[245,505]],"region":{"top_left_x":244,"top_left_y":459,"width":1568,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"044465f57fdb4bc8a8c86408dcea5342","type":"text","conversion_output":true,"text":"information about the participant's walking ability. This information will be used as part of the","text_display":" information about the participant's walking ability. This information will be used as part of the","confidence":1,"confidence_rate":1},{"cnt":[[245,503],[1785,503],[1785,552],[245,552]],"region":{"top_left_x":244,"top_left_y":502,"width":1542,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"344d1be44deb477c8d77c2b8d85bfcd7","type":"text","conversion_output":true,"text":"adjudication process, as described in section 11.5. Also, the four-week phone calls will be","text_display":" adjudication process, as described in section 11.5. Also, the four-week phone calls will be","confidence":0.99609375,"confidence_rate":0.9999592310464812},{"cnt":[[245,546],[1270,546],[1270,595],[245,595]],"region":{"top_left_x":244,"top_left_y":545,"width":1026,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2965f7e0a0c94214b3bacf8b4bbf1f26","type":"text","conversion_output":true,"text":"conducted with a proxy when the participant is not available.","text_display":" conducted with a proxy when the participant is not available.","confidence":1,"confidence_rate":1},{"cnt":[[245,636],[1794,636],[1794,681],[245,681]],"region":{"top_left_x":244,"top_left_y":635,"width":1550,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d674450311a245fba8febeadeaa7ae12","type":"text","conversion_output":true,"text":"In the description of measures below, we identify the measures that will not be collected for","text_display":"\n\nIn the description of measures below, we identify the measures that will not be collected for","confidence":0.97216796875,"confidence_rate":0.9997120141075819},{"cnt":[[245,679],[1248,679],[1248,728],[245,728]],"region":{"top_left_x":244,"top_left_y":678,"width":1005,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b048d15f95584fd08361f5658772efa6","type":"text","conversion_output":true,"text":"participants consented under protocol version 11.0 or later.","text_display":" participants consented under protocol version 11.0 or later.","confidence":1,"confidence_rate":1},{"cnt":[[271,765],[831,765],[831,827],[271,827]],"region":{"top_left_x":270,"top_left_y":764,"width":562,"height":64},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a4051f6d8584cc5b558c8384426fcbd","type":"section_header","conversion_output":false,"children_ids":["d3d137863bc849778c2f2916051ee956"],"text":"","text_display":""},{"cnt":[[277,773],[827,773],[827,823],[277,823]],"region":{"top_left_x":277,"top_left_y":773,"width":551,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3d137863bc849778c2f2916051ee956","type":"text","conversion_output":true,"parent_id":"6a4051f6d8584cc5b558c8384426fcbd","text":"10.1 Screening Evaluations","text_display":"\n\n\\subsection*{10.1 Screening Evaluations}","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1850,821],[1850,866],[245,866]],"region":{"top_left_x":244,"top_left_y":820,"width":1606,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d19e297740a54beebb985fb47a5697a6","type":"text","conversion_output":true,"text":"There will be three primary components to the screening process: the chart review in the acute","text_display":"\n\nThere will be three primary components to the screening process: the chart review in the acute","confidence":1,"confidence_rate":1},{"cnt":[[245,864],[1772,864],[1772,913],[245,913]],"region":{"top_left_x":244,"top_left_y":863,"width":1529,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5e827a3c19e4caba2acd69a77bd1a34","type":"text","conversion_output":true,"text":"care setting (phase 1 ), the phase 2 screen, and screening for final eligibility (phase 3 ) that","text_display":" care setting (phase 1 ), the phase 2 screen, and screening for final eligibility (phase 3 ) that","confidence":0.8609075546264648,"confidence_rate":0.9986393978224113},{"cnt":[[245,907],[1717,907],[1717,956],[245,956]],"region":{"top_left_x":244,"top_left_y":906,"width":1473,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95b93e7c92034f74b56ab2442f667b16","type":"text","conversion_output":true,"text":"includes calculated BMI, the 3MS, and the SMWT. These components will be typically","text_display":" includes calculated BMI, the 3MS, and the SMWT. These components will be typically","confidence":0.607421875,"confidence_rate":0.9942861369923347},{"cnt":[[245,950],[1865,950],[1865,999],[245,999]],"region":{"top_left_x":244,"top_left_y":949,"width":1621,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c744fcbfcbfa4da5b16a7d6710bda6a6","type":"text","conversion_output":true,"text":"administered over three contacts, in-person or by telephone (phase 2). Those who qualify after","text_display":" administered over three contacts, in-person or by telephone (phase 2). Those who qualify after","confidence":0.9941432476043701,"confidence_rate":0.9999406687255161},{"cnt":[[245,993],[1798,993],[1798,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":992,"width":1555,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d289c64ac49246788e27abf0f7b445a4","type":"text","conversion_output":true,"text":"phases 1 and 2 will be invited for the first clinic visit for phase 3 screening (see section 7.5).","text_display":" phases 1 and 2 will be invited for the first clinic visit for phase 3 screening (see section 7.5).","confidence":1,"confidence_rate":1},{"cnt":[[365,1074],[947,1074],[947,1137],[365,1137]],"region":{"top_left_x":365,"top_left_y":1074,"width":583,"height":63},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"268ab64c41644102ac77c5357ce66aba","type":"section_header","conversion_output":false,"children_ids":["fafb274bce0548ae818afa006f9d8d2e"],"text":"","text_display":""},{"cnt":[[372,1083],[943,1083],[943,1128],[372,1128]],"region":{"top_left_x":371,"top_left_y":1082,"width":573,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fafb274bce0548ae818afa006f9d8d2e","type":"text","conversion_output":true,"parent_id":"268ab64c41644102ac77c5357ce66aba","text":"10.1.1 Weight, Height, and BMI","text_display":"\n\n\\subsection*{10.1.1 Weight, Height, and BMI}","confidence":1,"confidence_rate":1},{"cnt":[[245,1126],[1721,1126],[1721,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1125,"width":1477,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee851e9f752847c388762b5424f95175","type":"text","conversion_output":true,"text":"Height (in feet and inches) will be measured once at the baseline visit using a standard","text_display":"\n\nHeight (in feet and inches) will be measured once at the baseline visit using a standard","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,1171],[1841,1171],[1841,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1170,"width":1598,"height":49},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"667c9926117245a2a1086cbef3908886","type":"text","conversion_output":true,"text":"stadiometer. Weight (in pounds) will be measured using a digital scale at baseline and at each","text_display":" stadiometer. Weight (in pounds) will be measured using a digital scale at baseline and at each","confidence":1,"confidence_rate":1},{"cnt":[[245,1212],[1497,1212],[1497,1261],[245,1261]],"region":{"top_left_x":244,"top_left_y":1211,"width":1254,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8282c4ed64b14638a7045747195b30c4","type":"text","conversion_output":true,"text":"follow-up visit. Measured height and weight will be used to calculate BMI.","text_display":" follow-up visit. Measured height and weight will be used to calculate BMI.","confidence":0.99951171875,"confidence_rate":0.999993817734324},{"cnt":[[365,1296],[1343,1296],[1343,1356],[365,1356]],"region":{"top_left_x":365,"top_left_y":1295,"width":978,"height":61},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"376ded4e5f6444b19cc22e05f0d1303a","type":"section_header","conversion_output":false,"children_ids":["598741d334ff4270b06910899aa40d0a"],"text":"","text_display":""},{"cnt":[[374,1302],[1338,1302],[1338,1351],[374,1351]],"region":{"top_left_x":373,"top_left_y":1301,"width":966,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"598741d334ff4270b06910899aa40d0a","type":"text","conversion_output":true,"parent_id":"376ded4e5f6444b19cc22e05f0d1303a","text":"10.1.2 Modified Mini-Mental State Examination (3MS)","text_display":"\n\n\\subsection*{10.1.2 Modified Mini-Mental State Examination (3MS)}","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[245,1345],[1760,1345],[1760,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1344,"width":1516,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eefcd98f7ac2402f898725adff66831d","type":"text","conversion_output":true,"text":"The 3MS is a test of global cognitive function which assesses a broad variety of cognitive","text_display":"\n\nThe 3MS is a test of global cognitive function which assesses a broad variety of cognitive","confidence":0.7021484375,"confidence_rate":0.9962847036151716},{"cnt":[[245,1388],[1790,1388],[1790,1437],[245,1437]],"region":{"top_left_x":244,"top_left_y":1387,"width":1546,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"676ddeb7e02041a59d0faa4ebd84c2d7","type":"text","conversion_output":true,"text":"dimensions and is an expanded 100 point version of the original Folstein Mini-Mental State","text_display":" dimensions and is an expanded 100 point version of the original Folstein Mini-Mental State","confidence":1,"confidence_rate":1},{"cnt":[[245,1431],[1837,1431],[1837,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1430,"width":1593,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad58e48f9117430bbb5275b5da69c968","type":"text","conversion_output":true,"text":"Exam. \\({ }^{153,154}\\) The 3MS will be used at the baseline visit to identify and exclude participants with","text_display":" Exam. \\({ }^{153,154}\\) The 3MS will be used at the baseline visit to identify and exclude participants with","confidence":0.92578125,"confidence_rate":0.9993177788068759},{"cnt":[[245,1474],[952,1474],[952,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1473,"width":708,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"340b4a03e8174ece9f95c697f19b7e35","type":"text","conversion_output":true,"text":"cognitive impairment (3MS score <73). \\({ }^{155}\\)","text_display":" cognitive impairment (3MS score <73). \\({ }^{155}\\)","confidence":0.4656608059791245,"confidence_rate":0.9854094543386988},{"cnt":[[269,1560],[1407,1560],[1407,1622],[269,1622]],"region":{"top_left_x":268,"top_left_y":1559,"width":1140,"height":64},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfcfe867cff146fb9dd192f2eca47807","type":"section_header","conversion_output":false,"children_ids":["19f47d22ca354edf91ad28d691d9c642"],"text":"","text_display":""},{"cnt":[[277,1566],[1403,1566],[1403,1618],[277,1618]],"region":{"top_left_x":277,"top_left_y":1566,"width":1126,"height":52},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19f47d22ca354edf91ad28d691d9c642","type":"text","conversion_output":true,"parent_id":"dfcfe867cff146fb9dd192f2eca47807","text":"10.2 Primary Outcome Measure: Community Ambulation","text_display":"\n\n\\subsection*{10.2 Primary Outcome Measure: Community Ambulation}","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1824,1611],[1824,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1581,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d60a994a59124d3395c913d42ea38f53","type":"text","conversion_output":true,"text":"The primary study outcome reflects the concept of a minimum distance a person needs to be","text_display":"\n\nThe primary study outcome reflects the concept of a minimum distance a person needs to be","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1850,1659],[1850,1706],[245,1706]],"region":{"top_left_x":244,"top_left_y":1658,"width":1606,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7190fb15c9214099b339886c75ca9bf0","type":"text","conversion_output":true,"text":"able to walk to carry out usual activities in the community. This will be defined as achieving the","text_display":" able to walk to carry out usual activities in the community. This will be defined as achieving the","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[1154,1702],[1154,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":910,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31df33c1831944b9bb7d6e043711da93","type":"text","conversion_output":true,"text":"threshold value of 300 meters or more on the SMWT.","text_display":" threshold value of 300 meters or more on the SMWT.","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1867,1788],[1867,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1787,"width":1623,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c76fe1bd998f4c15a4bed909479e4413","type":"text","conversion_output":true,"text":"Performance of the SMWT at the baseline assessment also will be used to define final eligibility","text_display":"\n\nPerformance of the SMWT at the baseline assessment also will be used to define final eligibility","confidence":1,"confidence_rate":1},{"cnt":[[245,1833],[1869,1833],[1869,1882],[245,1882]],"region":{"top_left_x":244,"top_left_y":1832,"width":1626,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f9a71e65b134196ad87eb782ca41a1f","type":"text","conversion_output":true,"text":"prior to the collection of additional baseline data. Participants who walk less than four meters in","text_display":" prior to the collection of additional baseline data. Participants who walk less than four meters in","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1841,1878],[1841,1925],[245,1925]],"region":{"top_left_x":244,"top_left_y":1877,"width":1598,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9556b306308c43989c9c8874c6233d2c","type":"text","conversion_output":true,"text":"40 seconds ( \\(<0.1 m / sec\\) ) or who walk 300 meters or more in six minutes will be excluded from","text_display":" 40 seconds ( \\(<0.1 m / sec\\) ) or who walk 300 meters or more in six minutes will be excluded from","confidence":0.8790237617213279,"confidence_rate":0.9988067925407708},{"cnt":[[245,1921],[1852,1921],[1852,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1920,"width":1608,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03b6f577263049ee9501c11eb587b7f1","type":"text","conversion_output":true,"text":"the trial. Participants with angina, extreme shortness of breath, or ambulating with severe pain","text_display":" the trial. Participants with angina, extreme shortness of breath, or ambulating with severe pain","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[922,1964],[922,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1963,"width":678,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5beb7dad9e844a3c9c552277965dcfed","type":"text","conversion_output":true,"text":"during the SMWT also will be excluded.","text_display":" during the SMWT also will be excluded.","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1803,2054],[1803,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2053,"width":1559,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c552b4354a5f4764b110e30d74320ec2","type":"text","conversion_output":true,"text":"Participants will be asked to walk back and forth on a measured path marked clearly at both","text_display":"\n\nParticipants will be asked to walk back and forth on a measured path marked clearly at both","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1863,2097],[1863,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2096,"width":1619,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cb6d4b4d2f64f6ba019e5a15f3e0c89","type":"text","conversion_output":true,"text":"ends for turning purposes, while being told when each minute has passed, and receiving verbal","text_display":" ends for turning purposes, while being told when each minute has passed, and receiving verbal","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1852,2140],[1852,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2139,"width":1608,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7d0db4190514c429808c26ae3dd3225","type":"text","conversion_output":true,"text":"encouragement (\"you're doing well\" or \"keep up the good work\") every 60 seconds. Test-retest","text_display":" encouragement (\"you're doing well\" or \"keep up the good work\") every 60 seconds. Test-retest","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1815,2183],[1815,2232],[245,2232]],"region":{"top_left_x":244,"top_left_y":2182,"width":1572,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74d639e3c1de4008b36403c1c16c8020","type":"text","conversion_output":true,"text":"reliability in older adults is excellent ( \\(r=.95\\) ). \\({ }^{107}\\) Concurrent validity with \\(V 0_{2}\\) peak ( \\(r=.64\\) ) and","text_display":" reliability in older adults is excellent ( \\(r=.95\\) ). \\({ }^{107}\\) Concurrent validity with \\(V 0_{2}\\) peak ( \\(r=.64\\) ) and","confidence":0.4276735406760034,"confidence_rate":0.9938192156687903},{"cnt":[[245,2226],[1137,2226],[1137,2277],[245,2277]],"region":{"top_left_x":244,"top_left_y":2225,"width":893,"height":53},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c1b61e0dbee456290d86b1bae338d25","type":"text","conversion_output":true,"text":"cycle ergometry ( \\(r =.58\\) ) have been reported. \\({ }^{105,156,157}\\)","text_display":" cycle ergometry ( \\(r =.58\\) ) have been reported. \\({ }^{105,156,157}\\)","confidence":0.8297886412341312,"confidence_rate":0.9974817671661526},{"cnt":[[245,2587],[662,2587],[662,2625],[245,2625]],"region":{"top_left_x":244,"top_left_y":2586,"width":418,"height":40},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1328ffb5546e41cd8b5165e09451d19c","type":"page_info","conversion_output":false,"text":"CAP Protocol version 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Secondary Outcome Measures - Precursors to Community Ambulation","text_display":"\n\n\\subsection*{10.3 Secondary Outcome Measures - Precursors to Community Ambulation}","confidence":1,"confidence_rate":1},{"cnt":[[372,339],[703,339],[703,385],[372,385]],"region":{"top_left_x":371,"top_left_y":339,"width":332,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4689d9e752fd402cbc2653abbd0a4b8f","type":"section_header","conversion_output":false,"children_ids":["7fa9e76df2094e65beea398203ecc54b"],"text":"","text_display":""},{"cnt":[[374,344],[698,344],[698,380],[374,380]],"region":{"top_left_x":373,"top_left_y":343,"width":326,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fa9e76df2094e65beea398203ecc54b","type":"text","conversion_output":true,"parent_id":"4689d9e752fd402cbc2653abbd0a4b8f","text":"10.3.1 Endurance","text_display":"\n\n\\subsection*{10.3.1 Endurance}","confidence":0.99951171875,"confidence_rate":0.9999767431038692},{"cnt":[[245,387],[1729,387],[1729,432],[245,432]],"region":{"top_left_x":244,"top_left_y":386,"width":1486,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdc736d4238b414db89254bae3f32d01","type":"text","conversion_output":true,"text":"To assess endurance, the SMWT (described above) will be used to obtain a continuous","text_display":"\n\nTo assess endurance, the SMWT (described above) will be used to obtain a continuous","confidence":1,"confidence_rate":1},{"cnt":[[247,430],[1725,430],[1725,477],[247,477]],"region":{"top_left_x":247,"top_left_y":429,"width":1479,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2316cc794b946b591e07fd62da2b769","type":"text","conversion_output":true,"text":"measure of total distance walked in six minutes. \\({ }^{158}\\) The SMWT is highly correlated with","text_display":" measure of total distance walked in six minutes. \\({ }^{158}\\) The SMWT is highly correlated with","confidence":1,"confidence_rate":1},{"cnt":[[245,477],[1811,477],[1811,522],[245,522]],"region":{"top_left_x":244,"top_left_y":476,"width":1568,"height":47},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eedc4fec682844ec9291504b020b0647","type":"text","conversion_output":true,"text":"workloads, heart rate, oxygen saturation, and dyspnea responses when compared to bicycle","text_display":" workloads, heart rate, oxygen saturation, and dyspnea responses when compared to bicycle","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1777,520],[1777,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":1533,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4512f3e321204cf1851718f9faa73303","type":"text","conversion_output":true,"text":"ergometry and treadmill exercise tests in older persons. \\({ }^{105,156,158}\\) It has been performed by","text_display":" ergometry and treadmill exercise tests in older persons. \\({ }^{105,156,158}\\) It has been performed by","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[247,563],[1781,563],[1781,608],[247,608]],"region":{"top_left_x":247,"top_left_y":562,"width":1535,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e994e03705d4476fa496ce66fc931396","type":"text","conversion_output":true,"text":"elderly, frail and severely compromised participants who cannot perform standard maximal","text_display":" elderly, frail and severely compromised participants who cannot perform standard maximal","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1051,606],[1051,651],[245,651]],"region":{"top_left_x":244,"top_left_y":605,"width":807,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d581dee412a4d5b841ad068370b36ab","type":"text","conversion_output":true,"text":"treadmill or cycle ergometry exercise tests. \\({ }^{31,159}\\)","text_display":" treadmill or cycle ergometry exercise tests. \\({ }^{31,159}\\)","confidence":0.9980475902557373,"confidence_rate":0.9999684792358122},{"cnt":[[370,692],[651,692],[651,735],[370,735]],"region":{"top_left_x":369,"top_left_y":691,"width":282,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6a6ae0202dc45adb4821e9ebfa554a4","type":"section_header","conversion_output":false,"children_ids":["415a2dc6c76947f3ba190001217864d2"],"text":"","text_display":""},{"cnt":[[374,696],[647,696],[647,733],[374,733]],"region":{"top_left_x":373,"top_left_y":696,"width":274,"height":37},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"415a2dc6c76947f3ba190001217864d2","type":"text","conversion_output":true,"parent_id":"e6a6ae0202dc45adb4821e9ebfa554a4","text":"10.3.2 Balance","text_display":"\n\n\\subsection*{10.3.2 Balance}","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[1790,739],[1790,780],[245,780]],"region":{"top_left_x":244,"top_left_y":739,"width":1546,"height":41},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d5e440de54c488dbd3769eb1d67b8e2","type":"text","conversion_output":true,"text":"We will use an enhanced balance measure that includes the balance subscale of the Short","text_display":"\n\nWe will use an enhanced balance measure that includes the balance subscale of the Short","confidence":1,"confidence_rate":1},{"cnt":[[247,782],[1876,782],[1876,827],[247,827]],"region":{"top_left_x":247,"top_left_y":782,"width":1629,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81aab3208a9845feac9bfc76983d3b9f","type":"text","conversion_output":true,"text":"Physical Performance Battery (SPPB) and two additional single leg stands (eyes open and eyes","text_display":" Physical Performance Battery (SPPB) and two additional single leg stands (eyes open and eyes","confidence":0.9921910762786865,"confidence_rate":0.999919182925369},{"cnt":[[245,829],[1807,829],[1807,874],[245,874]],"region":{"top_left_x":244,"top_left_y":829,"width":1563,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6cf0df0071342a0ad05afa5c81339f6","type":"text","conversion_output":true,"text":"closed), as used in the National Health and Aging Trends Study (NHATS). \\({ }^{160}\\) For the test of","text_display":" closed), as used in the National Health and Aging Trends Study (NHATS). \\({ }^{160}\\) For the test of","confidence":1,"confidence_rate":1},{"cnt":[[245,872],[1828,872],[1828,922],[245,922]],"region":{"top_left_x":244,"top_left_y":872,"width":1585,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51a2a454fb644d89a932c12cf92377a3","type":"text","conversion_output":true,"text":"standing balance, participants are asked to maintain balance in three positions, characterized","text_display":" standing balance, participants are asked to maintain balance in three positions, characterized","confidence":1,"confidence_rate":1},{"cnt":[[245,920],[1824,920],[1824,965],[245,965]],"region":{"top_left_x":244,"top_left_y":919,"width":1581,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b95aedfe19b443b28c3116ecdf961323","type":"text","conversion_output":true,"text":"by a progressive narrowing of the base support: with feet together (side-by-side position), the","text_display":" by a progressive narrowing of the base support: with feet together (side-by-side position), the","confidence":1,"confidence_rate":1},{"cnt":[[245,962],[1858,962],[1858,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":962,"width":1615,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c20e3fc82840428ea09a16759c880017","type":"text","conversion_output":true,"text":"heel of one foot beside the big toe of the other foot (semi-tandem position), and the heel of one","text_display":" heel of one foot beside the big toe of the other foot (semi-tandem position), and the heel of one","confidence":1,"confidence_rate":1},{"cnt":[[245,1005],[1824,1005],[1824,1053],[245,1053]],"region":{"top_left_x":244,"top_left_y":1005,"width":1581,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c88187f4c4aa4ed68baa5ffbe4ea48f5","type":"text","conversion_output":true,"text":"foot in front of and touching the toes of the other foot (tandem position). For each of the three","text_display":" foot in front of and touching the toes of the other foot (tandem position). For each of the three","confidence":1,"confidence_rate":1},{"cnt":[[245,1051],[1818,1051],[1818,1096],[245,1096]],"region":{"top_left_x":244,"top_left_y":1050,"width":1574,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad685ae149914e578242050bfccffa2c","type":"text","conversion_output":true,"text":"positions, participants are timed to a maximum of 10 seconds. Participants are then asked to","text_display":" positions, participants are timed to a maximum of 10 seconds. Participants are then asked to","confidence":1,"confidence_rate":1},{"cnt":[[245,1096],[1850,1096],[1850,1141],[245,1141]],"region":{"top_left_x":244,"top_left_y":1095,"width":1606,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a890e39f06dc4478aea73b6565319a99","type":"text","conversion_output":true,"text":"stand on one leg (on the side of the fracture) with eyes open and again with eyes closed. Each","text_display":" stand on one leg (on the side of the fracture) with eyes open and again with eyes closed. Each","confidence":1,"confidence_rate":1},{"cnt":[[245,1139],[1854,1139],[1854,1184],[245,1184]],"region":{"top_left_x":244,"top_left_y":1138,"width":1611,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cc7581095e64303846143093edc7a97","type":"text","conversion_output":true,"text":"of the single leg stands are held for up to 30 seconds. The number of seconds is then summed","text_display":" of the single leg stands are held for up to 30 seconds. The number of seconds is then summed","confidence":1,"confidence_rate":1},{"cnt":[[245,1182],[1790,1182],[1790,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1181,"width":1546,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"250a85b86f8948d3ba0db5d32b2b8f8c","type":"text","conversion_output":true,"text":"across the 5 items to obtain the measure of balance. These tests are hierarchical such that","text_display":" across the 5 items to obtain the measure of balance. These tests are hierarchical such that","confidence":1,"confidence_rate":1},{"cnt":[[245,1225],[1854,1225],[1854,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1224,"width":1611,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7378d669bbc49e88882f28799bca3f7","type":"text","conversion_output":true,"text":"when a participant fails an item, the harder ones are not administered and receive a score of 0 .","text_display":" when a participant fails an item, the harder ones are not administered and receive a score of 0 .","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[370,1311],[1025,1311],[1025,1360],[370,1360]],"region":{"top_left_x":369,"top_left_y":1310,"width":656,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"395cf230b68a49a699611da308622ccd","type":"section_header","conversion_output":false,"children_ids":["1e9a46e4323a485581d209c575bebd3a"],"text":"","text_display":""},{"cnt":[[374,1315],[1021,1315],[1021,1360],[374,1360]],"region":{"top_left_x":373,"top_left_y":1314,"width":648,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e9a46e4323a485581d209c575bebd3a","type":"text","conversion_output":true,"parent_id":"395cf230b68a49a699611da308622ccd","text":"10.3.3 Quadriceps Muscle Strength","text_display":"\n\n\\subsection*{10.3.3 Quadriceps Muscle Strength}","confidence":1,"confidence_rate":1},{"cnt":[[247,1358],[1721,1358],[1721,1403],[247,1403]],"region":{"top_left_x":247,"top_left_y":1357,"width":1474,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b12a9321729a48a6a44104c8d851e3b5","type":"text","conversion_output":true,"text":"Isometric force for bilateral knee extensors will be measured with a portable, hand-held","text_display":"\n\nIsometric force for bilateral knee extensors will be measured with a portable, hand-held","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1807,1401],[1807,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1400,"width":1563,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e404976bff664aeea11c164db5c824f9","type":"text","conversion_output":true,"text":"dynamometer (Microfet2 Manual Muscle Tester). Participants will be seated on the strength","text_display":" dynamometer (Microfet2 Manual Muscle Tester). Participants will be seated on the strength","confidence":1,"confidence_rate":1},{"cnt":[[245,1446],[1837,1446],[1837,1491],[245,1491]],"region":{"top_left_x":244,"top_left_y":1445,"width":1593,"height":47},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3a4c9895ee748ec88c195d8f44e1109","type":"text","conversion_output":true,"text":"testing chair, with hip flexion \\(90^{\\circ}\\) and knee flexed to \\(70^{\\circ}\\), stabilization straps on the pelvis and","text_display":" testing chair, with hip flexion \\(90^{\\circ}\\) and knee flexed to \\(70^{\\circ}\\), stabilization straps on the pelvis and","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1785,1487],[1785,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1486,"width":1542,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e34ebd097fc64f189756e18eb29900d9","type":"text","conversion_output":true,"text":"thigh, and resistance applied just proximal to the ankle on the anterior surface of the leg. \\({ }^{161}\\)","text_display":" thigh, and resistance applied just proximal to the ankle on the anterior surface of the leg. \\({ }^{161}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1534],[1766,1534],[1766,1579],[245,1579]],"region":{"top_left_x":244,"top_left_y":1533,"width":1523,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29368c274f0a449482172151aa5f805c","type":"text","conversion_output":true,"text":"Participants will be asked to push as hard and as fast as possible for five seconds. Three","text_display":" Participants will be asked to push as hard and as fast as possible for five seconds. Three","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1876,1577],[1876,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1576,"width":1632,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32801f9daee643d689d9b74ea4cf274e","type":"text","conversion_output":true,"text":"maximal effort trials, with a one-minute rest between trials, will be performed. The reported test-","text_display":" maximal effort trials, with a one-minute rest between trials, will be performed. The reported test","confidence":1,"confidence_rate":1},{"cnt":[[245,1620],[1848,1620],[1848,1667],[245,1667]],"region":{"top_left_x":244,"top_left_y":1619,"width":1604,"height":49},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0935a31022e4ea5b7308896716f5fbe","type":"text","conversion_output":true,"text":"retest reliability with hand-held dynamometry is excellent (r>.90) if tested in one session and in","text_display":"retest reliability with hand-held dynamometry is excellent (r>.90) if tested in one session and in","confidence":0.9591485231649131,"confidence_rate":0.99959513690022},{"cnt":[[245,1663],[1824,1663],[1824,1710],[245,1710]],"region":{"top_left_x":244,"top_left_y":1662,"width":1581,"height":49},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bbbce49fad14b41912e6d3aac52879f","type":"text","conversion_output":true,"text":"subjects with muscle weakness (intraclass correlation coefficient \\(\\geq .90\\) ). \\({ }^{162-164}\\) The peak force","text_display":" subjects with muscle weakness (intraclass correlation coefficient \\(\\geq .90\\) ). \\({ }^{162-164}\\) The peak force","confidence":1,"confidence_rate":1},{"cnt":[[245,1710],[1558,1710],[1558,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1710,"width":1314,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89f2914a51fc4841a1291b45fbcf02e9","type":"text","conversion_output":true,"text":"will be recorded for each of the three trials and the highest value will be used.","text_display":" will be recorded for each of the three trials and the highest value will be used.","confidence":1,"confidence_rate":1},{"cnt":[[245,1796],[1794,1796],[1794,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1796,"width":1550,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"107728c9547e4bdcb27494b04ef74eac","type":"text","conversion_output":true,"text":"This measure will not be collected for participants consented under protocol version 11.0 or","text_display":"\n\nThis measure will not be collected for participants consented under protocol version 11.0 or","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1839],[337,1839],[337,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1839,"width":94,"height":41},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70224e4c3f9e41a892b57605697bdc95","type":"text","conversion_output":true,"text":"later.","text_display":" later.","confidence":1,"confidence_rate":1},{"cnt":[[370,1925],[975,1925],[975,1974],[370,1974]],"region":{"top_left_x":369,"top_left_y":1925,"width":607,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80b645c4438c49569edd64fb24cb9596","type":"section_header","conversion_output":false,"children_ids":["a825c919a0594adaaca4a3b8a0f8d5d7"],"text":"","text_display":""},{"cnt":[[374,1929],[973,1929],[973,1970],[374,1970]],"region":{"top_left_x":373,"top_left_y":1929,"width":601,"height":42},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a825c919a0594adaaca4a3b8a0f8d5d7","type":"text","conversion_output":true,"parent_id":"80b645c4438c49569edd64fb24cb9596","text":"10.3.4 Lower Extremity Function","text_display":"\n\n\\subsection*{10.3.4 Lower Extremity Function}","confidence":0.99951171875,"confidence_rate":0.9999864334115239},{"cnt":[[245,1972],[1841,1972],[1841,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1972,"width":1598,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbad418d69cf4f43b0ff2b0d4fd48145","type":"text","conversion_output":true,"text":"A modified version of the Physical Performance Test (mPPT) \\({ }^{165}\\) will be used to measure lower","text_display":"\n\nA modified version of the Physical Performance Test (mPPT) \\({ }^{165}\\) will be used to measure lower","confidence":0.953125,"confidence_rate":0.9995514163522824},{"cnt":[[245,2015],[1863,2015],[1863,2060],[245,2060]],"region":{"top_left_x":244,"top_left_y":2015,"width":1619,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"affa05d6d7c044608e7eb1751f167dd7","type":"text","conversion_output":true,"text":"extremity function at baseline and follow-up. The modification, used by Binder et al., substitutes","text_display":" extremity function at baseline and follow-up. The modification, used by Binder et al., substitutes","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1811,2058],[1811,2105],[245,2105]],"region":{"top_left_x":244,"top_left_y":2058,"width":1568,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd5975e1cce642d79df382d94dc9d761","type":"text","conversion_output":true,"text":"a chair-rise task and a balance task for writing and eating tasks, in order to emphasize lower","text_display":" a chair-rise task and a balance task for writing and eating tasks, in order to emphasize lower","confidence":1,"confidence_rate":1},{"cnt":[[245,2101],[1871,2101],[1871,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2101,"width":1628,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e775dfebd5d4328aec809e733322488","type":"text","conversion_output":true,"text":"extremity function. \\({ }^{68}\\) The modified PPT includes nine standardized tasks that will be timed (e.g.,","text_display":" extremity function. \\({ }^{68}\\) The modified PPT includes nine standardized tasks that will be timed (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[245,2148],[1811,2148],[1811,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2148,"width":1568,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2673aea7e1934120bf9a88c84f41d016","type":"text","conversion_output":true,"text":"picking up a penny from the floor, standing up five times from a 16 -inch chair). The tasks are","text_display":" picking up a penny from the floor, standing up five times from a 16 -inch chair). The tasks are","confidence":0.966796875,"confidence_rate":0.9996722201153466},{"cnt":[[245,2191],[1863,2191],[1863,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2191,"width":1619,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dfc055f66c84bc99629f26cb0ff7e6f","type":"text","conversion_output":true,"text":"performed twice and the times from the two trials are averaged. The score for each item ranges","text_display":" performed twice and the times from the two trials are averaged. The score for each item ranges","confidence":1,"confidence_rate":1},{"cnt":[[245,2282],[245,2234],[1790,2237],[1790,2284]],"region":{"top_left_x":244,"top_left_y":2234,"width":1546,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79c0bc0dd2104fe984ee2cae972a51c1","type":"text","conversion_output":true,"text":"from 0 to 4, with 36 representing a perfect score. Test-retest reliability for the modified PPT","text_display":" from 0 to 4, with 36 representing a perfect score. Test-retest reliability for the modified PPT","confidence":0.69580078125,"confidence_rate":0.9965842254401989},{"cnt":[[245,2277],[1841,2277],[1841,2327],[245,2327]],"region":{"top_left_x":244,"top_left_y":2277,"width":1598,"height":50},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eff53f7e65c141e8a679758262934536","type":"text","conversion_output":true,"text":"score is \\(0.96 .^{22}\\) Because there is some overlap between the mPPT and SPPB items, we have","text_display":" score is \\(0.96 .^{22}\\) Because there is some overlap between the mPPT and SPPB items, we have","confidence":0.9912264347076416,"confidence_rate":0.9999136088336525},{"cnt":[[245,2325],[1846,2325],[1846,2370],[245,2370]],"region":{"top_left_x":244,"top_left_y":2324,"width":1602,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe33fc21da2b41cdbfe9710ba17bec74","type":"text","conversion_output":true,"text":"integrated the two scales so that participant burden is minimized but it is still possible to obtain","text_display":" integrated the two scales so that participant burden is minimized but it is still possible to obtain","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[746,2368],[746,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2367,"width":502,"height":42},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c5e6256d077401c9e35f6595a44f47e","type":"text","conversion_output":true,"text":"scores on each of the scales.","text_display":" scores on each of the scales.","confidence":1,"confidence_rate":1},{"cnt":[[247,2587],[660,2587],[660,2623],[247,2623]],"region":{"top_left_x":247,"top_left_y":2586,"width":413,"height":38},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f8fbb9318874d2c9e55b1ed5d639ae1","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19fa78156312460ea13238dc3fabdbdc","type":"page_info","conversion_output":false,"text":"33","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-053","page":53,"lines":[{"cnt":[[370,247],[870,247],[870,301],[370,301]],"region":{"top_left_x":369,"top_left_y":247,"width":502,"height":54},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a8420727900483e920ce297a2e999ae","type":"section_header","conversion_output":false,"children_ids":["754fb965962b4771b90d280065a9044a"],"text":"","text_display":""},{"cnt":[[374,251],[866,251],[866,299],[374,299]],"region":{"top_left_x":373,"top_left_y":251,"width":493,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"754fb965962b4771b90d280065a9044a","type":"text","conversion_output":true,"parent_id":"8a8420727900483e920ce297a2e999ae","text":"10.3.5 Fast Walking Speed","text_display":"\n\n\\subsection*{10.3.5 Fast Walking Speed}","confidence":1,"confidence_rate":1},{"cnt":[[245,294],[1869,294],[1869,342],[245,342]],"region":{"top_left_x":244,"top_left_y":294,"width":1626,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c818efbb6504ffb9395a8696b2f96d2","type":"text","conversion_output":true,"text":"Within the mPPT, participants are asked to walk a distance of 50 feet walking quickly but safely.","text_display":"\n\nWithin the mPPT, participants are asked to walk a distance of 50 feet walking quickly but safely.","confidence":0.9990234375,"confidence_rate":0.9999906949037896},{"cnt":[[245,339],[1485,339],[1485,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1241,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56f0821b363549ddb11980b37440dd23","type":"text","conversion_output":true,"text":"The time required to walk 50 ft will be the measure of fast walking speed.","text_display":" The time required to walk 50 ft will be the measure of fast walking speed.","confidence":1,"confidence_rate":1},{"cnt":[[370,421],[1278,421],[1278,471],[370,471]],"region":{"top_left_x":369,"top_left_y":421,"width":910,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cf6c19c73e045ada57867ceb8eabfd3","type":"section_header","conversion_output":false,"children_ids":["d30c63bfe9d74a728168e7f9dc6ef6f3"],"text":"","text_display":""},{"cnt":[[374,425],[1274,425],[1274,466],[374,466]],"region":{"top_left_x":373,"top_left_y":425,"width":902,"height":42},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d30c63bfe9d74a728168e7f9dc6ef6f3","type":"text","conversion_output":true,"parent_id":"1cf6c19c73e045ada57867ceb8eabfd3","text":"10.3.6 Cost Effectiveness: Health Care Utilization","text_display":"\n\n\\subsection*{10.3.6 Cost Effectiveness: Health Care Utilization}","confidence":0.9985356330871582,"confidence_rate":0.9999733559886682},{"cnt":[[245,471],[1850,471],[1850,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1606,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a0d86ade62c46848ba13dde2bb5b393","type":"text","conversion_output":true,"text":"Resource utilization will be tracked every four weeks via telephone interview and unit costs will","text_display":"\n\nResource utilization will be tracked every four weeks via telephone interview and unit costs will","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,516],[1871,516],[1871,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1628,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad7a76ca27c94107888a07a3d895a58b","type":"text","conversion_output":true,"text":"be assigned to each resource for which data are obtained. Resource use will reflect health care","text_display":" be assigned to each resource for which data are obtained. Resource use will reflect health care","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1841,559],[1841,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1598,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a3590003b8f4e86b0bf8acf784e5ec4","type":"text","conversion_output":true,"text":"use (including both formal and informal care) since the last telephone interview. This interview","text_display":" use (including both formal and informal care) since the last telephone interview. This interview","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1841,602],[1841,647],[245,647]],"region":{"top_left_x":244,"top_left_y":601,"width":1598,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"009d5e3b6d1a49f993b4897fb613b40c","type":"text","conversion_output":true,"text":"will be patterned after that used in the NIH-sponsored Spine Patient Outcomes Research Trial","text_display":" will be patterned after that used in the NIH-sponsored Spine Patient Outcomes Research Trial","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1858,645],[1858,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1615,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76f5934a405440d4b81644e312ceef4e","type":"text","conversion_output":true,"text":"(SPORT). \\({ }^{166}\\) In addition to caregiver costs, the questionnaire will document other resource use","text_display":" (SPORT). \\({ }^{166}\\) In addition to caregiver costs, the questionnaire will document other resource use","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1785,692],[1785,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1542,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33d770090c6c445b96e1b54742ef21c9","type":"text","conversion_output":true,"text":"including hospitalizations, other care facilities, health care visits, and diagnostic tests. As in","text_display":" including hospitalizations, other care facilities, health care visits, and diagnostic tests. As in","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1876,735],[1876,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1632,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b551c442fd98423f8b4baa22a08de9e9","type":"text","conversion_output":true,"text":"SPORT, a health diary will be provided to each participant to assist them in accurately recording","text_display":" SPORT, a health diary will be provided to each participant to assist them in accurately recording","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1106,778],[1106,821],[245,821]],"region":{"top_left_x":244,"top_left_y":777,"width":863,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41190ce2f2d04a079cd8e911422889ab","type":"text","conversion_output":true,"text":"health care encounters and use of health services.","text_display":" health care encounters and use of health services.","confidence":1,"confidence_rate":1},{"cnt":[[245,866],[1876,866],[1876,909],[245,909]],"region":{"top_left_x":244,"top_left_y":865,"width":1632,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae351a37bd884b3c8d41d25a8c955109","type":"text","conversion_output":true,"text":"Effectiveness will be assessed in the QALY framework where health state values will be used to","text_display":"\n\nEffectiveness will be assessed in the QALY framework where health state values will be used to","confidence":1,"confidence_rate":1},{"cnt":[[245,907],[1867,907],[1867,956],[245,956]],"region":{"top_left_x":244,"top_left_y":906,"width":1623,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04ea584cc91247e899eaf5232e61e7b3","type":"text","conversion_output":true,"text":"reflect the desirability for health outcomes on a scale from 0 (worst imaginable health state) to 1","text_display":" reflect the desirability for health outcomes on a scale from 0 (worst imaginable health state) to 1","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1824,954],[1824,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1581,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2a1d4b18e30497794ea70ac05818eaf","type":"text","conversion_output":true,"text":"(best imaginable health state). To estimate QALYs, health state values will be obtained using","text_display":" (best imaginable health state). To estimate QALYs, health state values will be obtained using","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1811,997],[1811,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1568,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"531c3f56c727408cb9cd37bfedfded75","type":"text","conversion_output":true,"text":"the SF-6D health state classification system, \\({ }^{167}\\) which defines health states using participant","text_display":" the SF-6D health state classification system, \\({ }^{167}\\) which defines health states using participant","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1833,1042],[1833,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1589,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"334f657247af43d9afe174b65f0854e6","type":"text","conversion_output":true,"text":"responses to the SF-36 (described below). QALYs estimated using SF-6D are consistent with","text_display":" responses to the SF-36 (described below). QALYs estimated using SF-6D are consistent with","confidence":1,"confidence_rate":1},{"cnt":[[245,1085],[1798,1085],[1798,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1084,"width":1555,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae893a6579b74852905b368eb149048b","type":"text","conversion_output":true,"text":"recommendations to use societal values in economic evaluations in health and medicine. \\({ }^{136}\\)","text_display":" recommendations to use societal values in economic evaluations in health and medicine. \\({ }^{136}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1126],[1846,1126],[1846,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1125,"width":1602,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc14653c4e3b4154b9e0b6a47ff05f4a","type":"text","conversion_output":true,"text":"Although current SF-6D scoring uses preference weights from a UK population, use of the SF-","text_display":" Although current SF-6D scoring uses preference weights from a UK population, use of the SF","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1798,1173],[1798,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1555,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"129f6d91dab74862bdae4912ca2d78d4","type":"text","conversion_output":true,"text":"6D will facilitate the planned model-based comparison between trial interventions and usual","text_display":"6D will facilitate the planned model-based comparison between trial interventions and usual","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1876,1216],[1876,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1632,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e5db2c54ef44002ac32db81431cf0d2","type":"text","conversion_output":true,"text":"care, because several BHS investigations have utilized SF-36 in similar hip fracture populations.","text_display":" care, because several BHS investigations have utilized SF-36 in similar hip fracture populations.","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[1755,1302],[1755,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1301,"width":1512,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4208c465570c499598a252d9943e722d","type":"text","conversion_output":true,"text":"Costs associated with participant-reported resource utilization will be estimated using the","text_display":"\n\nCosts associated with participant-reported resource utilization will be estimated using the","confidence":1,"confidence_rate":1},{"cnt":[[245,1347],[1876,1347],[1876,1396],[245,1396]],"region":{"top_left_x":244,"top_left_y":1347,"width":1632,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68e8b5b8aa6246f097aef95df7a66ef8","type":"text","conversion_output":true,"text":"Resource-Based Relative Value Scale (RBRVS) \\({ }^{168-170}\\), which is used by the Center for Medicare","text_display":" Resource-Based Relative Value Scale (RBRVS) \\({ }^{168-170}\\), which is used by the Center for Medicare","confidence":0.9970722198486328,"confidence_rate":0.9999731005958906},{"cnt":[[245,1392],[1876,1392],[1876,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1392,"width":1632,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2cdbcd2e071f49a892875344f0cbc376","type":"text","conversion_output":true,"text":"and Medicaid Services (CMS) to reimburse physicians for their services. This approach has the","text_display":" and Medicaid Services (CMS) to reimburse physicians for their services. This approach has the","confidence":1,"confidence_rate":1},{"cnt":[[245,1435],[1820,1435],[1820,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1435,"width":1576,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1824733403624feca72dfcda1404e0d7","type":"text","conversion_output":true,"text":"advantage of reflecting national fee schedules and relating them to the RBRVS. To estimate","text_display":" advantage of reflecting national fee schedules and relating them to the RBRVS. To estimate","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1768,1482],[1768,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1482,"width":1525,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5152d6f2f6c54cf0a9481984944991c0","type":"text","conversion_output":true,"text":"costs of other health care services not consistently covered by Medicare, providers will be","text_display":" costs of other health care services not consistently covered by Medicare, providers will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1828,1525],[1828,1573],[245,1573]],"region":{"top_left_x":244,"top_left_y":1525,"width":1585,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"597780273d6c45cebbdb125b8926e0da","type":"text","conversion_output":true,"text":"surveyed on charges for services at the geographic locations involved in this study. For each","text_display":" surveyed on charges for services at the geographic locations involved in this study. For each","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1749,1568],[1749,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1505,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9956af8b967545888b7592505fea2f85","type":"text","conversion_output":true,"text":"item, units of utilization will be multiplied by prevailing charges to estimate costs for each","text_display":" item, units of utilization will be multiplied by prevailing charges to estimate costs for each","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1876,1611],[1876,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1632,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8bb49df7f294c368c101a82b0870af5","type":"text","conversion_output":true,"text":"participant. To estimate indirect costs, information about informal caregivers' employment status","text_display":" participant. To estimate indirect costs, information about informal caregivers' employment status","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1858,1659],[1858,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1615,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a36a882a25734409aa2f962e2b4ffe4a","type":"text","conversion_output":true,"text":"and job class will be obtained at baseline. This will allow for estimation of the indirect economic","text_display":" and job class will be obtained at baseline. This will allow for estimation of the indirect economic","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[1858,1702],[1858,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":1615,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"760265079fd743ab8bf443a404d23c71","type":"text","conversion_output":true,"text":"costs associated with informal caregiving. Costs associated with providing the interventions will","text_display":" costs associated with informal caregiving. Costs associated with providing the interventions will","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,1745],[1656,1745],[1656,1792],[245,1792]],"region":{"top_left_x":244,"top_left_y":1744,"width":1413,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7aa2544d8d840bba41e0f43f1b31ddc","type":"text","conversion_output":true,"text":"be estimated based on the amount of physical therapist time required to deliver the","text_display":" be estimated based on the amount of physical therapist time required to deliver the","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[947,1788],[947,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":704,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ccbff5fdcdc471896ccf984a7f591ff","type":"text","conversion_output":true,"text":"interventions as recorded during the trial.","text_display":" interventions as recorded during the trial.","confidence":1,"confidence_rate":1},{"cnt":[[245,1876],[1796,1876],[1796,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1875,"width":1553,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a5fca68304c4f94b499eb6880c7dae8","type":"text","conversion_output":true,"text":"This measure will not be collected for participants consented under protocol version 11.0 or","text_display":"\n\nThis measure will not be collected for participants consented under protocol version 11.0 or","confidence":0.99365234375,"confidence_rate":0.99993632314463},{"cnt":[[245,1921],[337,1921],[337,1962],[245,1962]],"region":{"top_left_x":244,"top_left_y":1920,"width":94,"height":42},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3411e932c76c400fbc2779231c99dee5","type":"text","conversion_output":true,"text":"later.","text_display":" later.","confidence":1,"confidence_rate":1},{"cnt":[[275,2007],[750,2007],[750,2060],[275,2060]],"region":{"top_left_x":275,"top_left_y":2006,"width":475,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8e1e1e231da4417a335d8c013f648d5","type":"section_header","conversion_output":false,"children_ids":["f21403069ddd402d8ce2551d5419d7db"],"text":"","text_display":""},{"cnt":[[279,2011],[746,2011],[746,2056],[279,2056]],"region":{"top_left_x":279,"top_left_y":2010,"width":467,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f21403069ddd402d8ce2551d5419d7db","type":"text","conversion_output":true,"parent_id":"f8e1e1e231da4417a335d8c013f648d5","text":"10.4 Tertiary Outcomes","text_display":"\n\n\\subsection*{10.4 Tertiary Outcomes}","confidence":0.99755859375,"confidence_rate":0.9999094710853311},{"cnt":[[245,2056],[1792,2056],[1792,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2056,"width":1548,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"337db832607f481297c88be2e4b0c8d4","type":"text","conversion_output":true,"text":"A series of outcomes that are relevant for the recovering hip fracture participant also will be","text_display":"\n\nA series of outcomes that are relevant for the recovering hip fracture participant also will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2101],[1738,2101],[1738,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2101,"width":1495,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abc641af248a4102927fea2666dcd280","type":"text","conversion_output":true,"text":"evaluated. These were selected since: 1) all are affected by a hip fracture; and 2) all are","text_display":" evaluated. These were selected since: 1) all are affected by a hip fracture; and 2) all are","confidence":0.9960954189300537,"confidence_rate":0.9999592484986185},{"cnt":[[245,2144],[1545,2144],[1545,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2144,"width":1301,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4da665752ae448909cae6a43e70a1f64","type":"text","conversion_output":true,"text":"important in understanding the degree to which hip fracture patients recover.","text_display":" important in understanding the degree to which hip fracture patients recover.","confidence":1,"confidence_rate":1},{"cnt":[[370,2228],[1085,2228],[1085,2279],[370,2279]],"region":{"top_left_x":369,"top_left_y":2227,"width":716,"height":53},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd8e156a369e4dfb95c6c2b71b953a3c","type":"section_header","conversion_output":false,"children_ids":["a72efe958fe5437e96c9233aa4e116b7"],"text":"","text_display":""},{"cnt":[[374,2230],[1081,2230],[1081,2277],[374,2277]],"region":{"top_left_x":373,"top_left_y":2230,"width":708,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a72efe958fe5437e96c9233aa4e116b7","type":"text","conversion_output":true,"parent_id":"cd8e156a369e4dfb95c6c2b71b953a3c","text":"10.4.1 Activities of Daily Living (ADLs)","text_display":"\n\n\\subsection*{10.4.1 Activities of Daily Living (ADLs)}","confidence":0.99951171875,"confidence_rate":0.9999891467144949},{"cnt":[[245,2273],[1850,2273],[1850,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2273,"width":1606,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8fcc33585734b4882291eab5afa6b88","type":"text","conversion_output":true,"text":"We will measure ADLs using the Pepper Assessment Tool for Disability (PAT-D) \\({ }^{171,172}\\) with two","text_display":"\n\nWe will measure ADLs using the Pepper Assessment Tool for Disability (PAT-D) \\({ }^{171,172}\\) with two","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1833,2320],[1833,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2320,"width":1589,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d4724576c794cfa9910095c4e330199","type":"text","conversion_output":true,"text":"modifications. First, two items (walking a quarter mile and walking across a small room) were","text_display":" modifications. First, two items (walking a quarter mile and walking across a small room) were","confidence":1,"confidence_rate":1},{"cnt":[[245,2363],[1815,2363],[1815,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2363,"width":1572,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2ad3223ab0d4171854438d38fd0429d","type":"text","conversion_output":true,"text":"added to address perceived gaps in the original PAT-D scale. This modification is consistent","text_display":" added to address perceived gaps in the original PAT-D scale. This modification is consistent","confidence":1,"confidence_rate":1},{"cnt":[[245,2406],[1755,2406],[1755,2456],[245,2456]],"region":{"top_left_x":244,"top_left_y":2406,"width":1512,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f18cce11f254ed781605e0143b67693","type":"text","conversion_output":true,"text":"with the version used in the Lifestyle Interventions and Independence for Elders study. \\({ }^{173}\\)","text_display":" with the version used in the Lifestyle Interventions and Independence for Elders study. \\({ }^{173}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,2451],[1772,2451],[1772,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2451,"width":1529,"height":48},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3edf69f291a44b59aa466cbb492174c9","type":"text","conversion_output":true,"text":"Second, two items (walking several blocks and lifting heavy objects) were deleted to avoid","text_display":" Second, two items (walking several blocks and lifting heavy objects) were deleted to avoid","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b32a129675ed4048b9cf51a71aa10949","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbe2d420da144f3d898fc0a2f6147e2c","type":"page_info","conversion_output":false,"text":"34","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-054","page":54,"lines":[{"cnt":[[245,249],[1871,249],[1871,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1628,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"993565ae7da64cb7a3ef396c931abd52","type":"text","conversion_output":true,"text":"duplication with other items in the scale. The resulting 19-item scale allows examination of three","text_display":"\nduplication with other items in the scale. The resulting 19-item scale allows examination of three","confidence":0.98681640625,"confidence_rate":0.9998711610309794},{"cnt":[[245,296],[1394,296],[1394,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1151,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ba1bc86b33b42e6a8b36db24a4abdfb","type":"text","conversion_output":true,"text":"subscales (basic ADL, functional limitations, and instrumental ADL).","text_display":" subscales (basic ADL, functional limitations, and instrumental ADL).","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1794,382],[1794,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1550,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7960478938e6495eab468398373e2692","type":"text","conversion_output":true,"text":"This measure will not be collected for participants consented under protocol version 11.0 or","text_display":"\n\nThis measure will not be collected for participants consented under protocol version 11.0 or","confidence":0.99560546875,"confidence_rate":0.999955958813992},{"cnt":[[245,430],[337,430],[337,471],[245,471]],"region":{"top_left_x":244,"top_left_y":429,"width":94,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7c76a0470924cab98ad6b11e13aafe1","type":"text","conversion_output":true,"text":"later.","text_display":" 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(SF-36)}","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1807,559],[1807,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1563,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a3a1fa35e4947b6a68121ea045925a0","type":"text","conversion_output":true,"text":"We will use an interviewer-administered version of the SF-36, a health survey that assesses","text_display":"\n\nWe will use an interviewer-administered version of the SF-36, a health survey that assesses","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1858,602],[1858,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1615,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"229f1e852db7428f9586da0f2b0c78c7","type":"text","conversion_output":true,"text":"quality of life in eight subscales (physical function, social function, role-physical, role-emotional,","text_display":" quality of life in eight subscales (physical function, social function, role-physical, role-emotional,","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1876,645],[1876,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1632,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1f2d663f64f4761b3871291b9bae4e6","type":"text","conversion_output":true,"text":"bodily pain, mental health, general health, and vitality). \\({ }^{174}\\) The measure has been validated as a","text_display":" bodily pain, mental health, general health, and vitality). \\({ }^{174}\\) The measure has been validated as a","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1880,692],[1880,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1636,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"673262163a9340099112dee5f42ef954","type":"text","conversion_output":true,"text":"generic measure of quality of life in many different populations, including patient and non-patient","text_display":" generic measure of quality of life in many different populations, including patient and non-patient","confidence":1,"confidence_rate":1},{"cnt":[[245,730],[580,730],[580,780],[245,780]],"region":{"top_left_x":244,"top_left_y":730,"width":337,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05fbcade83b4462bae76da7aec70ad6b","type":"text","conversion_output":true,"text":"samples. \\({ }^{17468,175,176}\\)","text_display":" samples. \\({ }^{17468,175,176}\\)","confidence":0.56689453125,"confidence_rate":0.9829476115797503},{"cnt":[[245,821],[1794,821],[1794,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1550,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9204007671a54ee885e15091a4323406","type":"text","conversion_output":true,"text":"This measure will not be collected for participants consented under protocol version 11.0 or","text_display":"\n\nThis measure will not be collected for participants consented under protocol version 11.0 or","confidence":0.998046875,"confidence_rate":0.9999804498427488},{"cnt":[[245,868],[337,868],[337,909],[245,909]],"region":{"top_left_x":244,"top_left_y":867,"width":94,"height":42},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a35b3ef45967483585ebfd447cced18d","type":"text","conversion_output":true,"text":"later.","text_display":" 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Confidence}","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1760,997],[1760,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1516,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eeaa7b04310d4f608cfa0c8c278b5423","type":"text","conversion_output":true,"text":"The Activities-specific Balance Confidence (ABC) scale \\({ }^{177}\\) is a 16 -item measure that asks","text_display":"\n\nThe Activities-specific Balance Confidence (ABC) scale \\({ }^{177}\\) is a 16 -item measure that asks","confidence":0.7783048069104552,"confidence_rate":0.9976819773580149},{"cnt":[[245,1042],[1794,1042],[1794,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1550,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac09628c0c6c461c83dcef5b76e1e3bc","type":"text","conversion_output":true,"text":"respondents to rate their confidence in maintaining their balance while doing daily activities.","text_display":" respondents to rate their confidence in maintaining their balance while doing daily activities.","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1846,1087],[1846,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1602,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df6bec49f331460cafdf2134dff13c17","type":"text","conversion_output":true,"text":"Test-retest reliability, internal consistency, and concurrent validity with fall and physical activity","text_display":" Test-retest reliability, internal consistency, and concurrent validity with fall and physical activity","confidence":1,"confidence_rate":1},{"cnt":[[245,1126],[1682,1126],[1682,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1125,"width":1439,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26144b93a49e48bea4c67842dfdb96ac","type":"text","conversion_output":true,"text":"are high. \\({ }^{177,178}\\) This measure has been used successfully in hip fracture patients. \\({ }^{32,179}\\)","text_display":" are high. \\({ }^{177,178}\\) This measure has been used successfully in hip fracture patients. \\({ }^{32,179}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1794,1216],[1794,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1550,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"873014f742b742f1a5326f3c07ff92de","type":"text","conversion_output":true,"text":"This measure will not be collected for participants consented under protocol version 11.0 or","text_display":"\n\nThis measure will not be collected for participants consented under protocol version 11.0 or","confidence":0.99755859375,"confidence_rate":0.9999755563853322},{"cnt":[[245,1263],[337,1263],[337,1304],[245,1304]],"region":{"top_left_x":244,"top_left_y":1263,"width":94,"height":42},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f4601aa3d3c4ed6b03a4119db1bff84","type":"text","conversion_output":true,"text":"later.","text_display":" 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work, exercise, and recreation performed during a typical week in the past month. \\({ }^{180}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1775,1482],[1775,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1482,"width":1531,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9035abcc70d84f8a9142b6018573f3f4","type":"text","conversion_output":true,"text":"The YPAS increases the sensitivity of other physical activity surveys by describing a wider","text_display":" The YPAS increases the sensitivity of other physical activity surveys by describing a wider","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,1525],[1863,1525],[1863,1573],[245,1573]],"region":{"top_left_x":244,"top_left_y":1525,"width":1619,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"079b2c062e124e5984078ac2f4805aef","type":"text","conversion_output":true,"text":"range of lower intensity activities that older adults often engage in. Participation in each activity","text_display":" range of lower intensity activities that older adults often engage in. 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The measure has been validated against","text_display":" to calculate a weekly energy expenditure summary. The measure has been validated against","confidence":1,"confidence_rate":1},{"cnt":[[245,1654],[1830,1654],[1830,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1654,"width":1587,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c967cfa6214450db0a6db048bafc2e5","type":"text","conversion_output":true,"text":"several physiological variables of habitual activity. \\({ }^{180,181}\\) The YPAS has been used to estimate","text_display":" several physiological variables of habitual activity. \\({ }^{180,181}\\) The YPAS has been used to estimate","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,1697],[1287,1697],[1287,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1697,"width":1043,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f311c5d847747e3be727c7b604fe36c","type":"text","conversion_output":true,"text":"change in older adults in an exercise intervention program. \\({ }^{182}\\)","text_display":" change in older adults in an exercise intervention program. \\({ }^{182}\\)","confidence":0.9990236759185791,"confidence_rate":0.9999868000736574},{"cnt":[[245,1788],[1794,1788],[1794,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1550,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d445a51afcca4d279b03b4535eb3b365","type":"text","conversion_output":true,"text":"This measure will not be collected for participants consented under protocol version 11.0 or","text_display":"\n\nThis measure will not be collected for participants consented under protocol version 11.0 or","confidence":0.994140625,"confidence_rate":0.9999412356418027},{"cnt":[[245,1833],[337,1833],[337,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1832,"width":94,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"425e462f13fb4105bf863f944cae66db","type":"text","conversion_output":true,"text":"later.","text_display":" later.","confidence":1,"confidence_rate":1},{"cnt":[[370,1914],[947,1914],[947,1970],[370,1970]],"region":{"top_left_x":369,"top_left_y":1914,"width":579,"height":57},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d52fe2916144ca0b2b882b1c40f81f7","type":"section_header","conversion_output":false,"children_ids":["afd164541cd34745818c4274118a4c6c"],"text":"","text_display":""},{"cnt":[[374,1921],[943,1921],[943,1966],[374,1966]],"region":{"top_left_x":373,"top_left_y":1920,"width":571,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afd164541cd34745818c4274118a4c6c","type":"text","conversion_output":true,"parent_id":"2d52fe2916144ca0b2b882b1c40f81f7","text":"10.4.5 Improvement in Walking","text_display":"\n\n\\subsection*{10.4.5 Improvement in Walking}","confidence":0.9990234375,"confidence_rate":0.9999712639526579},{"cnt":[[245,1964],[1878,1964],[1878,2007],[245,2007]],"region":{"top_left_x":244,"top_left_y":1963,"width":1634,"height":44},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2ecdf6b60e2475e931baa2a4d9189fa","type":"text","conversion_output":true,"text":"Whether or not there was an increase of at least 50 meters in the distance walked on the SMWT","text_display":"\n\nWhether or not there was an increase of at least 50 meters in the distance walked on the SMWT","confidence":0.9873106479644775,"confidence_rate":0.9998735669092799},{"cnt":[[245,2007],[1682,2007],[1682,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1439,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08b512f695b7437692cc79d25302d1f7","type":"text","conversion_output":true,"text":"will be assessed as a tertiary outcome. This distance has been shown to be clinically","text_display":" will be assessed as a tertiary outcome. 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The test takes about \\(10-15\\) minutes to administer and was","text_display":" an inability to complete the test. The test takes about \\(10-15\\) minutes to administer and was","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,2359],[1876,2359],[1876,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2358,"width":1632,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ccd3488a09c492795b2008474607d53","type":"text","conversion_output":true,"text":"designed to be administered by a lay interviewer in a setting with limited space. The battery has","text_display":" designed to be administered by a lay interviewer in a setting with limited space. The battery has","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1781,2402],[1781,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1538,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0da54411ac7e413ebe4c65b649089609","type":"text","conversion_output":true,"text":"an excellent safety record. It has been administered to well over 10,000 persons in various","text_display":" an excellent safety record. It has been administered to well over 10,000 persons in various","confidence":0.99853515625,"confidence_rate":0.9999851928603086},{"cnt":[[245,2447],[1824,2447],[1824,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2447,"width":1581,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab3dd5c52197492e9847d046d1d8dfad","type":"text","conversion_output":true,"text":"studies and no serious injuries are known to have occurred. The SPPB components and total","text_display":" studies and no serious injuries are known to have occurred. The SPPB components and total","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93a8596a86b04af1a2755413a344d582","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"801f46d80565446fb2860036d923563d","type":"page_info","conversion_output":false,"text":"35","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-055","page":55,"lines":[{"cnt":[[245,249],[1803,249],[1803,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1559,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c8e529052b4419a98ec09f519656191","type":"text","conversion_output":true,"text":"score are derived from normative values obtained from a population-based study. \\({ }^{184,186}\\) The","text_display":"\nscore are derived from normative values obtained from a population-based study. \\({ }^{184,186}\\) The","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1641,296],[1641,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1398,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6b094205e2c4bf99422eae683b90d0f","type":"text","conversion_output":true,"text":"total score ranges from 0 to 12; there are three subscales embedded in the SPPB.","text_display":" total score ranges from 0 to 12; there are three subscales embedded in the SPPB.","confidence":0.830243308795616,"confidence_rate":0.9978881821451006},{"cnt":[[309,382],[1760,382],[1760,432],[309,432]],"region":{"top_left_x":309,"top_left_y":382,"width":1451,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7063bae1844140cdaf104205c194b349","type":"text","conversion_output":true,"text":"Standing balance. For the test of standing balance, participants are asked to maintain","text_display":"\n\nStanding balance. For the test of standing balance, participants are asked to maintain","confidence":1,"confidence_rate":1},{"cnt":[[309,430],[1824,430],[1824,475],[309,475]],"region":{"top_left_x":309,"top_left_y":429,"width":1516,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f1e28c56ad946aa9da49a82630aa821","type":"text","conversion_output":true,"text":"balance in three positions, characterized by a progressive narrowing of the base support:,","text_display":" balance in three positions, characterized by a progressive narrowing of the base support:,","confidence":0.87744140625,"confidence_rate":0.9986246824133084},{"cnt":[[307,473],[1858,473],[1858,518],[307,518]],"region":{"top_left_x":307,"top_left_y":472,"width":1552,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d664322ff39f480b86f719d1e8583c49","type":"text","conversion_output":true,"text":"with feet together (side-by-side position), the heel of one foot beside the big toe of the other","text_display":" with feet together (side-by-side position), the heel of one foot beside the big toe of the other","confidence":1,"confidence_rate":1},{"cnt":[[307,516],[1854,516],[1854,561],[307,561]],"region":{"top_left_x":307,"top_left_y":515,"width":1548,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03d6c57c37ed4244b2425d1f76f21ec7","type":"text","conversion_output":true,"text":"foot (semi-tandem position), and the heel of one foot in front of and touching the toes of the","text_display":" foot (semi-tandem position), and the heel of one foot in front of and touching the toes of the","confidence":1,"confidence_rate":1},{"cnt":[[307,559],[1781,559],[1781,604],[307,604]],"region":{"top_left_x":307,"top_left_y":558,"width":1475,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d08fd1bc15ad450bb0b8891bf9a34382","type":"text","conversion_output":true,"text":"other foot (tandem position). For each of the three positions, participants are timed to a","text_display":" other foot (tandem position). For each of the three positions, participants are timed to a","confidence":1,"confidence_rate":1},{"cnt":[[307,604],[741,604],[741,642],[307,642]],"region":{"top_left_x":307,"top_left_y":603,"width":435,"height":40},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bbfd7cef0f041a5b57aafbdb60e9343","type":"text","conversion_output":true,"text":"maximum of 10 seconds.","text_display":" maximum of 10 seconds.","confidence":1,"confidence_rate":1},{"cnt":[[309,692],[1785,692],[1785,737],[309,737]],"region":{"top_left_x":309,"top_left_y":691,"width":1477,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ccca8c193474d1f836a889a6dd35b22","type":"text","conversion_output":true,"text":"Walking speed. Walking speed is assessed by asking participants to walk at their usual","text_display":"\n\nWalking speed. 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Participants are instructed to stand with both feet touching the","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[309,778],[1869,778],[1869,823],[309,823]],"region":{"top_left_x":309,"top_left_y":777,"width":1561,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82096dee2095444696cd7f26a4e6fe11","type":"text","conversion_output":true,"text":"starting line and to start walking after a specific verbal command. Participants are allowed to","text_display":" starting line and to start walking after a specific verbal command. Participants are allowed to","confidence":1,"confidence_rate":1},{"cnt":[[309,821],[1852,821],[1852,870],[309,870]],"region":{"top_left_x":309,"top_left_y":820,"width":1543,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b3d3a7049c148f2bf79ad8d60b1a688","type":"text","conversion_output":true,"text":"use walking aids (cane, walker, or other walking aid) if necessary, but not the assistance of","text_display":" use walking aids (cane, walker, or other walking aid) if necessary, but not the assistance of","confidence":1,"confidence_rate":1},{"cnt":[[309,868],[1772,868],[1772,913],[309,913]],"region":{"top_left_x":309,"top_left_y":867,"width":1464,"height":47},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69aedde3d4af4f6b832e93e3aafd9d43","type":"text","conversion_output":true,"text":"another person. Timing begins as soon as the participant starts to walk and the time in","text_display":" another person. Timing begins as soon as the participant starts to walk and the time in","confidence":1,"confidence_rate":1},{"cnt":[[309,911],[1871,911],[1871,956],[309,956]],"region":{"top_left_x":309,"top_left_y":910,"width":1563,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02f4cc0969a142509b573546579978b3","type":"text","conversion_output":true,"text":"seconds needed to complete the entire distance is recorded. The faster of two walks is used","text_display":" seconds needed to complete the entire distance is recorded. 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The repeated chair stands test is performed using a straight-backed chair,","confidence":1,"confidence_rate":1},{"cnt":[[307,1087],[1867,1087],[1867,1132],[307,1132]],"region":{"top_left_x":307,"top_left_y":1087,"width":1560,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a18c0c6b7774a93884f20386c298871","type":"text","conversion_output":true,"text":"which is placed with its back against a wall. Participants are first asked to stand once from a","text_display":" which is placed with its back against a wall. Participants are first asked to stand once from a","confidence":1,"confidence_rate":1},{"cnt":[[307,1130],[1854,1130],[1854,1175],[307,1175]],"region":{"top_left_x":307,"top_left_y":1130,"width":1548,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f91e5adf00104ba488d77919242694b5","type":"text","conversion_output":true,"text":"sitting position with their arms folded across their chest. If they are able to perform the task,","text_display":" sitting position with their arms folded across their chest. If they are able to perform the task,","confidence":1,"confidence_rate":1},{"cnt":[[307,1175],[1852,1175],[1852,1222],[307,1222]],"region":{"top_left_x":307,"top_left_y":1175,"width":1545,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5900f1a2709b4d4f9d80e4034b4e2335","type":"text","conversion_output":true,"text":"they are then asked to stand up and sit down five times, as quickly as possible. The time to","text_display":" they are then asked to stand up and sit down five times, as quickly as possible. 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A total of six brief statements is","text_display":"\n\nThe LOT-R assesses self-reported optimism and pessimism. A total of six brief statements is","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1854,1087],[1854,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1611,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2732bfcc109747a0b4b34b7687d85797","type":"text","conversion_output":true,"text":"read to the participant, and response categories range from strongly disagree to strongly agree","text_display":" read to the participant, and response categories range from strongly disagree to strongly agree","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1708,1130],[1708,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1465,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0158507c002a4f1bae06c77d0db2c0b5","type":"text","conversion_output":true,"text":"on a 5-point Likert type scale; three items measure optimism and three items measure","text_display":" on a 5-point Likert type scale; three items measure optimism and three items measure","confidence":0.99755859375,"confidence_rate":0.9999725353059057},{"cnt":[[245,1173],[486,1173],[486,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":242,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8050ef4c5c6b4bc59377777a37767348","type":"text","conversion_output":true,"text":"pessimism. \\({ }^{197}\\)","text_display":" pessimism. \\({ }^{197}\\)","confidence":1,"confidence_rate":1},{"cnt":[[243,1259],[629,1259],[629,1308],[243,1308]],"region":{"top_left_x":242,"top_left_y":1258,"width":388,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d860e0eccd944c7c99fa83c8f4e7e628","type":"section_header","conversion_output":false,"children_ids":["434953f9ce9048fa82d46b3a62791b45"],"text":"","text_display":""},{"cnt":[[245,1263],[625,1263],[625,1304],[245,1304]],"region":{"top_left_x":244,"top_left_y":1263,"width":382,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"434953f9ce9048fa82d46b3a62791b45","type":"text","conversion_output":true,"parent_id":"d860e0eccd944c7c99fa83c8f4e7e628","text":"Brief Resilience Scale","text_display":"\n\n\\section*{Brief Resilience Scale}","confidence":0.99951171875,"confidence_rate":0.9999819112562659},{"cnt":[[245,1306],[1858,1306],[1858,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1615,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d113970ca66494c99fff763a90182bc","type":"text","conversion_output":true,"text":"The Brief Resilience Scale assesses self-reported ability to bounce back after a stressful event.","text_display":"\n\nThe Brief Resilience Scale assesses self-reported ability to bounce back after a stressful event.","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1850,1349],[1850,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1349,"width":1606,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f94a534457c844e58d48ffc4283d8658","type":"text","conversion_output":true,"text":"A total of six brief statements is read, and response categories range from strongly disagree to","text_display":" A total of six brief statements is read, and response categories range from strongly disagree to","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[1051,1392],[1051,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1392,"width":807,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c67eb85599654b53be5bfe95f1f75f7e","type":"text","conversion_output":true,"text":"strongly agree on a 5-point Likert-type scale. \\({ }^{198}\\)","text_display":" strongly agree on a 5-point Likert-type scale. \\({ }^{198}\\)","confidence":0.986328125,"confidence_rate":0.9997743501223683},{"cnt":[[275,1478],[1033,1478],[1033,1532],[275,1532]],"region":{"top_left_x":275,"top_left_y":1478,"width":759,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"935aa1365459429fae0a2b17217d6488","type":"section_header","conversion_output":false,"children_ids":["b758715dd5564d988f99465164e94c4c"],"text":"","text_display":""},{"cnt":[[279,1482],[1029,1482],[1029,1525],[279,1525]],"region":{"top_left_x":279,"top_left_y":1482,"width":751,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b758715dd5564d988f99465164e94c4c","type":"text","conversion_output":true,"parent_id":"935aa1365459429fae0a2b17217d6488","text":"10.6 Other Measures to be Monitored","text_display":"\n\n\\subsection*{10.6 Other Measures to be Monitored}","confidence":1,"confidence_rate":1},{"cnt":[[370,1573],[703,1573],[703,1622],[370,1622]],"region":{"top_left_x":369,"top_left_y":1572,"width":334,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fe7c8e613484b2bb584bc46820a0a8a","type":"section_header","conversion_output":false,"children_ids":["eb79b238f35a40eea47d28bfc9d84188"],"text":"","text_display":""},{"cnt":[[374,1577],[698,1577],[698,1618],[374,1618]],"region":{"top_left_x":373,"top_left_y":1576,"width":326,"height":42},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb79b238f35a40eea47d28bfc9d84188","type":"text","conversion_output":true,"parent_id":"7fe7c8e613484b2bb584bc46820a0a8a","text":"10.6.1 Adherence","text_display":"\n\n\\subsection*{10.6.1 Adherence}","confidence":1,"confidence_rate":1},{"cnt":[[245,1620],[1766,1620],[1766,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1619,"width":1523,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"364366423467486a81e146e02be6be22","type":"text","conversion_output":true,"text":"Adherence with PT interventions. 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For the PUSH group, we will","text_display":" performed; and whether activities were performed as prescribed. 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Logs completed by PTs will record the detail of","text_display":" every four weeks during the intervention period. Logs completed by PTs will record the detail of","confidence":1,"confidence_rate":1},{"cnt":[[245,1839],[1652,1839],[1652,1886],[245,1886]],"region":{"top_left_x":244,"top_left_y":1839,"width":1409,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a09b0a6fb224480b5542342fe02f64a","type":"text","conversion_output":true,"text":"each designated activity during intervention sessions as well as any precautions or","text_display":" each designated activity during intervention sessions as well as any precautions or","confidence":1,"confidence_rate":1},{"cnt":[[245,1884],[1794,1884],[1794,1931],[245,1931]],"region":{"top_left_x":244,"top_left_y":1884,"width":1550,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd38d7694ca04f199fb532d8281e2434","type":"text","conversion_output":true,"text":"modifications to activities. Reasons for protocol variations will be noted in the PT log books.","text_display":" modifications to activities. Reasons for protocol variations will be noted in the PT log books.","confidence":0.9956073760986328,"confidence_rate":0.9999559779708055},{"cnt":[[245,1972],[1861,1972],[1861,2020],[245,2020]],"region":{"top_left_x":244,"top_left_y":1972,"width":1617,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab0d6e017d974f9db9dea0c521696791","type":"text","conversion_output":true,"text":"Additionally, at the end of each intervention visit, the PT will retrieve the average HRs for laps 2","text_display":"\n\nAdditionally, at the end of each intervention visit, the PT will retrieve the average HRs for laps 2","confidence":0.9931747913360596,"confidence_rate":0.9999409620279242},{"cnt":[[245,2015],[1785,2015],[1785,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2015,"width":1542,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a913b91e2d7a457986f8adaf3eccdb29","type":"text","conversion_output":true,"text":"and 3 from the Polar heart rate monitor receiver and record them in the logbook and on the","text_display":" and 3 from the Polar heart rate monitor receiver and record them in the logbook and on the","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1792,2058],[1792,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2058,"width":1548,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1089f035e904159bbe7b0ad189371c1","type":"text","conversion_output":true,"text":"appropriate data forms. The Polar heart rate monitoring will provide a dichotomous variable","text_display":" appropriate data forms. The Polar heart rate monitoring will provide a dichotomous variable","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1824,2105],[1824,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2105,"width":1581,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09e9023ba8e149e785b39db6fdf60c84","type":"text","conversion_output":true,"text":"reflecting whether, during laps 2 and 3 of each intervention session, the participant's average","text_display":" reflecting whether, during laps 2 and 3 of each intervention session, the participant's average","confidence":1,"confidence_rate":1},{"cnt":[[245,2148],[1818,2148],[1818,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2148,"width":1574,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69c7b73cf06c4f2781b1e2cf0b62a1c2","type":"text","conversion_output":true,"text":"HR was equal to or greater than his or her target heart rate ( \\(\\pm 5\\) beats). 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Based on the adjudication, participants who","confidence":1,"confidence_rate":1},{"cnt":[[245,1549],[1766,1549],[1766,1596],[245,1596]],"region":{"top_left_x":244,"top_left_y":1549,"width":1523,"height":48},"line":74,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d20cea9bafa4d84b5664e267d3c10e5","type":"text","conversion_output":true,"text":"meet one or more of the following criteria at the follow-up assessment will be classified as","text_display":" meet one or more of the following criteria at the follow-up assessment will be classified as","confidence":1,"confidence_rate":1},{"cnt":[[245,1592],[1416,1592],[1416,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1591,"width":1172,"height":49},"line":75,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9df4452a18e34bf5a2257a2fb1d77fe8","type":"text","conversion_output":true,"text":"treatment failures in the primary analysis for the given follow-up time:","text_display":" treatment failures in the primary analysis for the given follow-up time:","confidence":0.99951171875,"confidence_rate":0.9999936571565041},{"cnt":[[309,1680],[642,1680],[642,1725],[309,1725]],"region":{"top_left_x":309,"top_left_y":1680,"width":334,"height":46},"line":76,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d96e27d6a5cb49579f7cc2059e8cc59d","type":"text","conversion_output":true,"text":"1) Participant died","text_display":"\n1) Participant died","confidence":1,"confidence_rate":1},{"cnt":[[305,1723],[1876,1723],[1876,1772],[305,1772]],"region":{"top_left_x":305,"top_left_y":1723,"width":1571,"height":50},"line":77,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b0902f00c5744ad83c3c841709876b2","type":"text","conversion_output":true,"text":"2) Participant was too sick, based on adjudicators' review of source documentation, to walk","text_display":"\n2) Participant was too sick, based on adjudicators' review of source documentation, to walk","confidence":1,"confidence_rate":1},{"cnt":[[370,1766],[870,1766],[870,1809],[370,1809]],"region":{"top_left_x":369,"top_left_y":1766,"width":502,"height":43},"line":78,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"602126b4fbe7476da0a50984d33a174f","type":"text","conversion_output":true,"text":"300 m or more in six minutes","text_display":" 300 m or more in six minutes","confidence":0.974609375,"confidence_rate":0.9992438586870325},{"cnt":[[305,1811],[1794,1811],[1794,1858],[305,1858]],"region":{"top_left_x":305,"top_left_y":1811,"width":1489,"height":48},"line":79,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ca40df17c444b98b1c1a572f0289135","type":"text","conversion_output":true,"text":"3) Gait speed based on SPPB four-meter walk was less than \\(0.6 m / s\\) (very slow speed","text_display":"\n3) Gait speed based on SPPB four-meter walk was less than \\(0.6 m / s\\) (very slow speed","confidence":1,"confidence_rate":1},{"cnt":[[370,1856],[1283,1856],[1283,1901],[370,1901]],"region":{"top_left_x":369,"top_left_y":1856,"width":914,"height":46},"line":80,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"816d61df676a400eb812010889cd93b9","type":"text","conversion_output":true,"text":"incompatible with ability to walk 300 m in six minutes)","text_display":" incompatible with ability to walk 300 m in six minutes)","confidence":1,"confidence_rate":1},{"cnt":[[305,1899],[1815,1899],[1815,1949],[305,1949]],"region":{"top_left_x":305,"top_left_y":1899,"width":1511,"height":50},"line":81,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2406adf6c46c4192a85a497868b8ee0f","type":"text","conversion_output":true,"text":"4) Participant or proxy reports (a) participant limitation in walking several blocks or (b) in","text_display":"\n4) Participant or proxy reports (a) participant limitation in walking several blocks or (b) in","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[370,1944],[1429,1944],[1429,1992],[370,1992]],"region":{"top_left_x":369,"top_left_y":1944,"width":1060,"height":48},"line":82,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72b0bbd9849842f28c273e9ff0e898e7","type":"text","conversion_output":true,"text":"walking across a small room without help from another person","text_display":" walking across a small room without help from another person","confidence":1,"confidence_rate":1},{"cnt":[[245,2032],[1742,2032],[1742,2078],[245,2078]],"region":{"top_left_x":244,"top_left_y":2032,"width":1499,"height":46},"line":83,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f208222aa86e40da9d245671f9d720d7","type":"text","conversion_output":true,"text":"Criterion 4a is an item from the Activity Limitations section of the SF-36 and was chosen","text_display":"\n\nCriterion 4a is an item from the Activity Limitations section of the SF-36 and was chosen","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1772,2075],[1772,2123],[245,2123]],"region":{"top_left_x":244,"top_left_y":2075,"width":1529,"height":48},"line":84,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b40ab6ef05d7455485f1e4289d7b4321","type":"text","conversion_output":true,"text":"because, in a previous hip fracture study performed by our group, \\(100 \\%\\) of 27 participants","text_display":" because, in a previous hip fracture study performed by our group, \\(100 \\%\\) of 27 participants","confidence":0.9208984375,"confidence_rate":0.9991762842106052},{"cnt":[[245,2118],[1785,2118],[1785,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2118,"width":1542,"height":50},"line":85,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"096382a7f41c4130892e5dbe69ac5682","type":"text","conversion_output":true,"text":"meeting the criterion were unable to walk 300 m or more in six minutes (unpublished data).","text_display":" meeting the criterion were unable to walk 300 m or more in six minutes (unpublished data).","confidence":1,"confidence_rate":1},{"cnt":[[245,2161],[1768,2161],[1768,2211],[245,2211]],"region":{"top_left_x":244,"top_left_y":2161,"width":1525,"height":50},"line":86,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d35cefa522a94205bd02c51a11cbf0ba","type":"text","conversion_output":true,"text":"Also, in that study, \\(85 \\%\\) of 26 participants who had a missing SMWT reported this level of","text_display":" Also, in that study, \\(85 \\%\\) of 26 participants who had a missing SMWT reported this level of","confidence":0.99853515625,"confidence_rate":0.9999853409306202},{"cnt":[[245,2209],[1800,2209],[1800,2254],[245,2254]],"region":{"top_left_x":244,"top_left_y":2208,"width":1557,"height":46},"line":87,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a101f94e6d04a2abb224cd72a35f4b4","type":"text","conversion_output":true,"text":"walking limitation, suggesting that use of this item will allow us to assign a classification to a","text_display":" walking limitation, suggesting that use of this item will allow us to assign a classification to a","confidence":1,"confidence_rate":1},{"cnt":[[245,2252],[1807,2252],[1807,2299],[245,2299]],"region":{"top_left_x":244,"top_left_y":2251,"width":1563,"height":48},"line":88,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"091f029a9ade4e7f8eba9abd34515bbb","type":"text","conversion_output":true,"text":"large proportion of those who were not tested on the SMWT. Criterion 4b is an item from the","text_display":" large proportion of those who were not tested on the SMWT. Criterion 4b is an item from the","confidence":1,"confidence_rate":1},{"cnt":[[245,2295],[1794,2295],[1794,2344],[245,2344]],"region":{"top_left_x":244,"top_left_y":2294,"width":1550,"height":50},"line":89,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0f5e94681f3480b9544a38f2029deff","type":"text","conversion_output":true,"text":"Pepper Assessment Tool for Disability and was chosen because it has high face validity for","text_display":" Pepper Assessment Tool for Disability and was chosen because it has high face validity for","confidence":1,"confidence_rate":1},{"cnt":[[245,2340],[1854,2340],[1854,2387],[245,2387]],"region":{"top_left_x":244,"top_left_y":2339,"width":1611,"height":48},"line":90,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cc0e64e78c44e0d8671d3cb8e26018c","type":"text","conversion_output":true,"text":"predicting treatment failure. To improve our ability to classify the outcome status of participants","text_display":" predicting treatment failure. To improve our ability to classify the outcome status of participants","confidence":1,"confidence_rate":1},{"cnt":[[245,2385],[1781,2385],[1781,2430],[245,2430]],"region":{"top_left_x":244,"top_left_y":2384,"width":1538,"height":46},"line":91,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44ab80d8a566490d807c66e9a5af3a9c","type":"text","conversion_output":true,"text":"whose SMWT was not administered, we will make intensive efforts to obtain self- or proxy-","text_display":" whose SMWT was not administered, we will make intensive efforts to obtain self- or proxy-","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81186cb1444547b2a37f719a54f8cf85","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1833,2587],[1882,2587],[1882,2625],[1833,2625]],"region":{"top_left_x":1832,"top_left_y":2586,"width":51,"height":40},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6456a45f187f46339e19599cf5bfd856","type":"page_info","conversion_output":false,"text":"40","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-060","page":60,"lines":[{"cnt":[[245,249],[1755,249],[1755,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1512,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88b407fdedea46b6abf0123231974578","type":"text","conversion_output":true,"text":"reported information on these two items in person or by telephone, even when other data","text_display":"\nreported information on these two items in person or by telephone, even when other data","confidence":0.9990234375,"confidence_rate":0.9999893800602199},{"cnt":[[245,296],[1051,296],[1051,346],[245,346]],"region":{"top_left_x":244,"top_left_y":296,"width":807,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4ef576351cb4d8e803431d9709a2e2f","type":"text","conversion_output":true,"text":"cannot be collected at the given follow-up time.","text_display":" cannot be collected at the given follow-up time.","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1876,382],[1876,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1632,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72dca9314e8f47c38b5a7f9da679db5c","type":"text","conversion_output":true,"text":"There will be three adjudicators, all experts in mobility assessment and the clinical management","text_display":"\n\nThere will be three adjudicators, all experts in mobility assessment and the clinical management","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1828,425],[1828,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1585,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f727e18c94bf4bb28f689e1ae519a745","type":"text","conversion_output":true,"text":"of older persons. Each adjudication case will be randomly assigned to two of the adjudicators","text_display":" of older persons. Each adjudication case will be randomly assigned to two of the adjudicators","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1858,471],[1858,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1615,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"873a2777057845c381146c64823948df","type":"text","conversion_output":true,"text":"who will independently review all the relevant documents and classify participants as treatment","text_display":" who will independently review all the relevant documents and classify participants as treatment","confidence":0.99853515625,"confidence_rate":0.9999853409306202},{"cnt":[[245,511],[1841,511],[1841,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1598,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9721862bdc440ec802d6c124d2bff89","type":"text","conversion_output":true,"text":"failures or indeterminate. If the two adjudicators disagree on the classification, the case will be","text_display":" failures or indeterminate. If the two adjudicators disagree on the classification, the case will be","confidence":1,"confidence_rate":1},{"cnt":[[245,556],[1775,556],[1775,606],[245,606]],"region":{"top_left_x":244,"top_left_y":556,"width":1531,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8f0127703fd4b94b9818b4a870d568f","type":"text","conversion_output":true,"text":"discussed in a meeting with the two adjudicators. If there is no consensus after discussion","text_display":" discussed in a meeting with the two adjudicators. If there is no consensus after discussion","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1820,602],[1820,651],[245,651]],"region":{"top_left_x":244,"top_left_y":601,"width":1576,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9aabbac916b9498f874b107bd983399c","type":"text","conversion_output":true,"text":"between the two assigned adjudicators, the case will be discussed in a meeting with all three","text_display":" between the two assigned adjudicators, the case will be discussed in a meeting with all three","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1830,645],[1830,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1587,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36bbef2633ab4ba8baa577afda17fe33","type":"text","conversion_output":true,"text":"adjudicators. Discrepancies will be resolved by a vote if the three adjudicators cannot reach a","text_display":" adjudicators. Discrepancies will be resolved by a vote if the three adjudicators cannot reach a","confidence":1,"confidence_rate":1},{"cnt":[[245,690],[1858,690],[1858,741],[245,741]],"region":{"top_left_x":244,"top_left_y":689,"width":1615,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ba563856a3d4bc7940f12f380d3919d","type":"text","conversion_output":true,"text":"consensus. To monitor the adjudication process, an unblinded statistician will calculate, among","text_display":" consensus. To monitor the adjudication process, an unblinded statistician will calculate, among","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1768,735],[1768,782],[245,782]],"region":{"top_left_x":244,"top_left_y":734,"width":1525,"height":49},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c880f5bf24344cd3bec0db2492f4de52","type":"text","conversion_output":true,"text":"the cases submitted for adjudication, the outcome of adjudication (proportion classified as","text_display":" the cases submitted for adjudication, the outcome of adjudication (proportion classified as","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1865,778],[1865,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1621,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e29b2af24074c1d856b691e3752af78","type":"text","conversion_output":true,"text":"failure and indeterminate), by treatment group. The incorporation of adjudication results into the","text_display":" failure and indeterminate), by treatment group. The incorporation of adjudication results into the","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[965,821],[965,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":721,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93b4ec7681d74ef6be1e66c83892f19c","type":"text","conversion_output":true,"text":"analysis plan is described in Section 15.1.","text_display":" analysis plan is described in Section 15.1.","confidence":1,"confidence_rate":1},{"cnt":[[245,907],[1841,907],[1841,958],[245,958]],"region":{"top_left_x":244,"top_left_y":906,"width":1598,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45c0a4b70387495fa7dca1d0d5f40c7e","type":"text","conversion_output":true,"text":"Cases where the SMWT was administered but not according to protocol (e.g., using a walking","text_display":"\n\nCases where the SMWT was administered but not according to protocol (e.g., using a walking","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1880,954],[1880,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":953,"width":1636,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c4a61390756414bb7faa1530771f389","type":"text","conversion_output":true,"text":"course of less than 10 m ) will also be submitted for adjudication. The adjudicators will review the","text_display":" course of less than 10 m ) will also be submitted for adjudication. The adjudicators will review the","confidence":1,"confidence_rate":1},{"cnt":[[245,999],[1833,999],[1833,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":999,"width":1589,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c25b2c2f64a47cab4c5349d34ff92ae","type":"text","conversion_output":true,"text":"description of the circumstances and outcome of the testing as recorded by the evaluator and","text_display":" description of the circumstances and outcome of the testing as recorded by the evaluator and","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1858,1042],[1858,1091],[245,1091]],"region":{"top_left_x":244,"top_left_y":1041,"width":1615,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31bcbf6a21fc4404b27363f92bd73013","type":"text","conversion_output":true,"text":"will judge whether the participant's classification (treatment success or treatment failure) based","text_display":" will judge whether the participant's classification (treatment success or treatment failure) based","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1815,1087],[1815,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1572,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"411110e43d2f44e2b40289c686c08bb5","type":"text","conversion_output":true,"text":"on the distance walked is valid. If not, the participant will be classified as 'indeterminate'. For","text_display":" on the distance walked is valid. If not, the participant will be classified as 'indeterminate'. For","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1278,1130],[1278,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1130,"width":1035,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51711abfa5dc48e09abf6f34368e8284","type":"text","conversion_output":true,"text":"simplicity, this part of the process is not depicted in Figure 4.","text_display":" simplicity, this part of the process is not depicted in Figure 4.","confidence":1,"confidence_rate":1},{"cnt":[[245,2582],[664,2582],[664,2628],[245,2628]],"region":{"top_left_x":244,"top_left_y":2582,"width":420,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d8d7012aae343668a50231120065554","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1830,2587],[1882,2587],[1882,2625],[1830,2625]],"region":{"top_left_x":1830,"top_left_y":2586,"width":53,"height":40},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2db8a676d1114bcd9e099eedeeefe3f8","type":"page_info","conversion_output":false,"text":"41","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-061","page":61,"lines":[{"cnt":[[245,249],[1207,249],[1207,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":964,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1851ccba765c4dd584d98c9d827bc401","type":"figure_label","conversion_output":false,"text":"Figure 4. Classification and Analysis of Primary Outcome","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[238,316],[1938,316],[1938,2464],[238,2464]],"region":{"top_left_x":238,"top_left_y":315,"width":1700,"height":2150},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1257aebb2f0e4cd69121fba8acb3a73c","type":"diagram","conversion_output":true,"selected_labels":["1851ccba765c4dd584d98c9d827bc401"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 4. Classification and Analysis of Primary Outcome}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/2efa872f-7404-4e9a-b558-82f18459fdff-061.jpg?height=2150&width=1700&top_left_y=315&top_left_x=238}\n\\end{figure}"},{"cnt":[[249,2484],[1921,2484],[1921,2524],[249,2524]],"region":{"top_left_x":249,"top_left_y":2483,"width":1672,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad9bbfe2700246f49fd09fef22e98880","type":"text","conversion_output":true,"text":"Note: This flow chart applies only to follow-up assessments. At baseline, all participants will be tested with the Six-Minute","text_display":"\n\nNote: This flow chart applies only to follow-up assessments. At baseline, all participants will be tested with the Six-Minute","confidence":1,"confidence_rate":1},{"cnt":[[249,2527],[397,2527],[397,2563],[249,2563]],"region":{"top_left_x":249,"top_left_y":2526,"width":149,"height":38},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd7c263d1f8d48b0b708ed421d789cf9","type":"text","conversion_output":true,"text":"Walk Test.","text_display":" Walk Test.","confidence":0.984375,"confidence_rate":0.9989506604776246},{"cnt":[[247,2587],[660,2587],[660,2623],[247,2623]],"region":{"top_left_x":247,"top_left_y":2586,"width":413,"height":38},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"316e3d32947d4a1e8f91d929eace74ed","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7fe5b4c8b184159bfa5e8d195eec8f8","type":"page_info","conversion_output":false,"text":"42","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-062","page":62,"lines":[{"cnt":[[243,249],[1012,249],[1012,314],[243,314]],"region":{"top_left_x":242,"top_left_y":249,"width":770,"height":65},"line":1,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"9703f4236b794f3d8b1caf7677b0631b","type":"section_header","conversion_output":false,"children_ids":["fef4966283a04c0faf9b590e8dd8f94d"],"text":"","text_display":""},{"cnt":[[249,254],[1008,254],[1008,312],[249,312]],"region":{"top_left_x":249,"top_left_y":253,"width":759,"height":59},"line":2,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"fef4966283a04c0faf9b590e8dd8f94d","type":"text","conversion_output":true,"parent_id":"9703f4236b794f3d8b1caf7677b0631b","text":"Section 12: Safety Assessments","text_display":"\n\n\\section*{Section 12: Safety Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[275,348],[1403,348],[1403,402],[275,402]],"region":{"top_left_x":275,"top_left_y":348,"width":1128,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0efaa9e12358433084194a01a0ca0b69","type":"section_header","conversion_output":false,"children_ids":["a50c11f114764b9883d86d889f592303"],"text":"","text_display":""},{"cnt":[[279,352],[1399,352],[1399,400],[279,400]],"region":{"top_left_x":279,"top_left_y":352,"width":1120,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a50c11f114764b9883d86d889f592303","type":"text","conversion_output":true,"parent_id":"0efaa9e12358433084194a01a0ca0b69","text":"12.1 Participant Safety Parameters: Methods and Timing","text_display":"\n\n\\subsection*{12.1 Participant Safety Parameters: Methods and Timing}","confidence":1,"confidence_rate":1},{"cnt":[[370,404],[1119,404],[1119,453],[370,453]],"region":{"top_left_x":369,"top_left_y":403,"width":751,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d79f66f4352f4f729d3b85d2d11fba0a","type":"section_header","conversion_output":false,"children_ids":["318c80b286a84f829d27f756da20722e"],"text":"","text_display":""},{"cnt":[[374,408],[1115,408],[1115,453],[374,453]],"region":{"top_left_x":373,"top_left_y":408,"width":743,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"318c80b286a84f829d27f756da20722e","type":"text","conversion_output":true,"parent_id":"d79f66f4352f4f729d3b85d2d11fba0a","text":"12.1.1 Pre-Intervention Safety Screening","text_display":"\n\n\\subsection*{12.1.1 Pre-Intervention Safety Screening}","confidence":0.9990234375,"confidence_rate":0.9999782882435296},{"cnt":[[247,451],[1841,451],[1841,496],[247,496]],"region":{"top_left_x":247,"top_left_y":451,"width":1595,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf2e9deb5010415781aaac28297e325d","type":"text","conversion_output":true,"text":"Potential participants will be excluded during the screening phases if they have cardiovascular","text_display":"\n\nPotential participants will be excluded during the screening phases if they have cardiovascular","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,494],[1843,494],[1843,541],[245,541]],"region":{"top_left_x":244,"top_left_y":494,"width":1600,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24e2eaf295ae435d82bb4e2d21bcd6f0","type":"text","conversion_output":true,"text":"diseases or other conditions that would make it unsafe for them to participate in one or both of","text_display":" diseases or other conditions that would make it unsafe for them to participate in one or both of","confidence":1,"confidence_rate":1},{"cnt":[[245,539],[1755,539],[1755,587],[245,587]],"region":{"top_left_x":244,"top_left_y":539,"width":1512,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7c0a919f740405081c4bb485fe47e06","type":"text","conversion_output":true,"text":"the study interventions. Information about these conditions will be obtained through chart","text_display":" the study interventions. Information about these conditions will be obtained through chart","confidence":1,"confidence_rate":1},{"cnt":[[245,584],[1755,584],[1755,629],[245,629]],"region":{"top_left_x":244,"top_left_y":584,"width":1512,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f29d318822f04e91839d1dc6d2bc12d0","type":"text","conversion_output":true,"text":"review, interviews, and consultation with a medical professional familiar with the potential","text_display":" review, interviews, and consultation with a medical professional familiar with the potential","confidence":1,"confidence_rate":1},{"cnt":[[245,627],[1811,627],[1811,672],[245,672]],"region":{"top_left_x":244,"top_left_y":627,"width":1568,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8601466ae4c4883abffadbafebed7ec","type":"text","conversion_output":true,"text":"participant (e.g., primary care provider, orthopaedic surgeon). The clinical site study clinician","text_display":" participant (e.g., primary care provider, orthopaedic surgeon). The clinical site study clinician","confidence":1,"confidence_rate":1},{"cnt":[[245,672],[1781,672],[1781,718],[245,718]],"region":{"top_left_x":244,"top_left_y":672,"width":1538,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec2359047fe44ff99fe5e147e81e9c37","type":"text","conversion_output":true,"text":"and PI will be responsible for giving permission for potential participants to be randomized,","text_display":" and PI will be responsible for giving permission for potential participants to be randomized,","confidence":0.8615584373474121,"confidence_rate":0.998480620802357},{"cnt":[[245,713],[1824,713],[1824,761],[245,761]],"region":{"top_left_x":244,"top_left_y":713,"width":1581,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb907808aa2946d5bedfbaddc8a267eb","type":"text","conversion_output":true,"text":"based on thorough review of all eligibility information. In addition, persons who develop chest","text_display":" based on thorough review of all eligibility information. In addition, persons who develop chest","confidence":1,"confidence_rate":1},{"cnt":[[245,758],[1813,758],[1813,806],[245,806]],"region":{"top_left_x":244,"top_left_y":758,"width":1570,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4996548c3dae4bf89029218e976b5c27","type":"text","conversion_output":true,"text":"pain or substantial shortness of breath during the SMWT will be excluded using a protocol to","text_display":" pain or substantial shortness of breath during the SMWT will be excluded using a protocol to","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[1532,799],[1532,849],[245,849]],"region":{"top_left_x":244,"top_left_y":799,"width":1288,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8af2f3d908904ad484ddf03c204d0e87","type":"text","conversion_output":true,"text":"evaluate cardiovascular reserve similar to the one suggested by Gill et al. \\({ }^{199}\\)","text_display":" evaluate cardiovascular reserve similar to the one suggested by Gill et al. \\({ }^{199}\\)","confidence":1,"confidence_rate":1},{"cnt":[[370,887],[1343,887],[1343,939],[370,939]],"region":{"top_left_x":369,"top_left_y":887,"width":974,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bbbba5d6e1c4b6c8fa6378a5f93c9cd","type":"section_header","conversion_output":false,"children_ids":["d400e6bcafd249e09551134bee5777b2"],"text":"","text_display":""},{"cnt":[[374,889],[1343,889],[1343,935],[374,935]],"region":{"top_left_x":373,"top_left_y":889,"width":970,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d400e6bcafd249e09551134bee5777b2","type":"text","conversion_output":true,"parent_id":"0bbbba5d6e1c4b6c8fa6378a5f93c9cd","text":"12.1.2 Safety Considerations for Study Assessments","text_display":"\n\n\\subsection*{12.1.2 Safety Considerations for Study Assessments}","confidence":0.9638845920562744,"confidence_rate":0.9993314288783859},{"cnt":[[245,937],[1790,937],[1790,982],[245,982]],"region":{"top_left_x":244,"top_left_y":936,"width":1546,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db062469e1c64ae2abb7cdfda853e040","type":"text","conversion_output":true,"text":"All study assessments will be done by certified staff who will be trained to perform the tests","text_display":"\n\nAll study assessments will be done by certified staff who will be trained to perform the tests","confidence":1,"confidence_rate":1},{"cnt":[[245,980],[1854,980],[1854,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":979,"width":1611,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2779eef86524f1c838c537dd70d44d4","type":"text","conversion_output":true,"text":"safely. If, during the SMWT, the SPPB, or the mPPT, a participant reports chest pain, tightness","text_display":" safely. If, during the SMWT, the SPPB, or the mPPT, a participant reports chest pain, tightness","confidence":1,"confidence_rate":1},{"cnt":[[245,1023],[1876,1023],[1876,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1022,"width":1632,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fa39a317adc4e728562ef1c5c9fc34e","type":"text","conversion_output":true,"text":"or pressure, significant shortness of breath or difficulty breathing, or feeling faint, lightheaded, or","text_display":" or pressure, significant shortness of breath or difficulty breathing, or feeling faint, lightheaded, or","confidence":1,"confidence_rate":1},{"cnt":[[245,1068],[1865,1068],[1865,1113],[245,1113]],"region":{"top_left_x":244,"top_left_y":1067,"width":1621,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c7afb317f944a8dbc2ee7711bbd3474","type":"text","conversion_output":true,"text":"dizzy, the test will be stopped. All research staff who come in contact with study participants will","text_display":" dizzy, the test will be stopped. All research staff who come in contact with study participants will","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,1111],[1727,1111],[1727,1158],[245,1158]],"region":{"top_left_x":244,"top_left_y":1110,"width":1484,"height":49},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94ad21476b9f44fc8caac33d58b06528","type":"text","conversion_output":true,"text":"be CPR certified and will be trained to provide immediate care when faced with medical","text_display":" be CPR certified and will be trained to provide immediate care when faced with medical","confidence":1,"confidence_rate":1},{"cnt":[[245,1156],[1858,1156],[1858,1201],[245,1201]],"region":{"top_left_x":244,"top_left_y":1155,"width":1615,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf7e97fdb4c84c839e4ff722cf1949ec","type":"text","conversion_output":true,"text":"emergencies. Also, institutional and community emergency medical services will be activated if","text_display":" emergencies. Also, institutional and community emergency medical services will be activated if","confidence":1,"confidence_rate":1},{"cnt":[[245,1199],[389,1199],[389,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1198,"width":145,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35c7376e57af4b659f4265bb6440abf7","type":"text","conversion_output":true,"text":"needed.","text_display":" needed.","confidence":1,"confidence_rate":1},{"cnt":[[245,1285],[1710,1285],[1710,1332],[245,1332]],"region":{"top_left_x":244,"top_left_y":1284,"width":1467,"height":49},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47b6da51daa241b1a9a31a7e6ff79cea","type":"text","conversion_output":true,"text":"Table 2 describes a summary of safety alerts and the appropriate action during clinical","text_display":"\n\nTable 2 describes a summary of safety alerts and the appropriate action during clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,1332],[483,1332],[483,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1332,"width":240,"height":37},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfa04f77316e482fafff4eacd9aadf82","type":"text","conversion_output":true,"text":"assessments.","text_display":" assessments.","confidence":1,"confidence_rate":1},{"cnt":[[247,2587],[660,2587],[660,2623],[247,2623]],"region":{"top_left_x":247,"top_left_y":2586,"width":413,"height":38},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81e7fd453c9d407f8ca83cbcdda3065c","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1833,2587],[1882,2587],[1882,2625],[1833,2625]],"region":{"top_left_x":1832,"top_left_y":2586,"width":51,"height":40},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76aa3546f0e54d1a9f8e1c1ee665a818","type":"page_info","conversion_output":false,"text":"43","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-063","page":63,"lines":[{"cnt":[[245,249],[1304,249],[1304,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1061,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e59c9dbb8fd4de0ac2ef6dcc3b063a3","type":"figure_label","conversion_output":false,"text":"Table 2. Safety Alerts and Actions for Study Assessments","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999919934665097},{"cnt":[[226,292],[1800,292],[1800,1809],[226,1809]],"region":{"top_left_x":225,"top_left_y":292,"width":1576,"height":1517},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6e2f53afcec4d37aa51dc9800eebfa9","type":"table","conversion_output":true,"children_ids":["6c9d9ed5b32043bcb06f6a218678c590","16d53d5739d84c39a1aee24353faa662","4745ea825159436c9ca04165558d0549","42b931e3aae5430da3a740f8c23c7e4e","2543c190d8324738b5cf2740f7fb13b5","de8a989878c744e299fa5af77c54e7a9","8765249734bc4155938b25e5727ebb7f","79a7fe4cf3ec48c08d9d63bb4b4aef98","ce979867bb544ccbb2b60f3e84265948","6bb3ecfbd360467fa71042676eb94d07","c73fe94ed24b48a2a39baf46c135c51e","70562b60e6ea4214b3905e31e8e0ebc3","034e658bd9d04761955bf79bc2ee8f57","b4b2cc748d4c41f5a4933d1efec75856","5c43211761b04d02ab086bad0bc89656","b014919277114cd8b5295b8da559b2ff","ae3f281ece8b416db921b1f3de7ecebd","231f7d54b1fb4764b0a367e373285e5e","9efb0c7d95b34355848c6f350b7e2f31","2f2e14e06af7456eb08cfd77a9864aaa","040db900f54c41be8e776952e3acc9ae","a7510baeddc349c582a1de97593ca368","99619272813e4ab1890d85924df42fc1","d11fe78727814398b5c4461b36d3409e","183f831118ad4ce4a611110c2844ba31","731ef1c7502c48fb999ed15e98925f51","cf7230ae291c4761935e861bfce053fe","88025680ee3848d1bcce2b808b19e7ba","b210c9d2eb0144ea994d06e67b86c341","3d987a74680b4ce788f74c1c996f7772","b3ff9cd936e44c5cb22ac6436009db45","a8de23bb8dcd4af4834d2256c87d8245"],"selected_labels":["7e59c9dbb8fd4de0ac2ef6dcc3b063a3"],"text":"\\begin{tabular}{|l|l|}\n\\hline ALERT & ACTION \\\\\n\\hline Resting blood pressure SBP \\(>145 mm\\) Hg or DBP \\(>90 mm Hg\\) & Qualified staff will inform the participant if noted on more than one occasion. \\\\\n\\hline \\begin{tabular}{l}\nResting blood pressure \\\\\nSBP \\(>170 mm Hg\\) or SBP \\(<90 mm\\) Hg or \\\\\nDBP \\(>100 mm Hg\\) or DBP \\(<50 mm Hg\\)\n\\end{tabular} & Qualified staff will encourage the participant to seek additional follow-up and/or medical evaluation. Physical performance testing will be deferred until consultation with the study clinician. \\\\\n\\hline \\begin{tabular}{l}\nResting blood pressure or after SMWT \\\\\nSBP \\(>185 mm\\) Hg or SBP \\(<90 mm\\) Hg or DBP \\(>110 mm Hg\\) or DBP \\(<50 mm Hg\\)\n\\end{tabular} & Qualified staff will consult with the study clinician and follow up as needed. \\\\\n\\hline \\begin{tabular}{l}\nResting pulse \\\\\nRate > 120 or < 40 beats/min\n\\end{tabular} & Qualified staff will consult with the study clinician and follow up as needed. \\\\\n\\hline Chest pain, dizziness, significant shortness of breath, or severe musculoskeletal pain during the intervention or study assessment. & Qualified staff will consult with the study clinician and follow up as needed. \\\\\n\\hline \\begin{tabular}{l}\nCES-D \\\\\nScore \\(\\geq 27\\)\n\\end{tabular} & Qualified staff will talk to the participant and provide a referral for additional follow-up and/or medical evaluation for depression. \\\\\n\\hline Weight loss \\(\\geq 2 \\%\\) in four weeks during intervention period & Participant will be referred to the registered dietician for follow-up by telephone. \\\\\n\\hline Weight not obtained at the final PT intervention visit and there is weight loss \\(\\geq 5 \\%\\) between baseline and follow-up. & Clinical site PI or clinical site clinician will review participant's weight trajectory, baseline BMI, baseline MNA®-SF score and registered dietician's documentation and, if warranted, will refer the participant to a dietician or medical provider for follow-up of possible poor nutritional status. \\\\\n\\hline Participant expresses desire to commit suicide & Call primary care provider and report findings. Report to clinical site coordinator/study clinician for follow-up and clearance. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 2. Safety Alerts and Actions for Study Assessments}\n\\begin{tabular}{|l|l|}\n\\hline ALERT & ACTION \\\\\n\\hline Resting blood pressure SBP \\(>145 mm\\) Hg or DBP \\(>90 mm Hg\\) & Qualified staff will inform the participant if noted on more than one occasion. \\\\\n\\hline \\begin{tabular}{l}\nResting blood pressure \\\\\nSBP \\(>170 mm Hg\\) or SBP \\(<90 mm\\) Hg or \\\\\nDBP \\(>100 mm Hg\\) or DBP \\(<50 mm Hg\\)\n\\end{tabular} & Qualified staff will encourage the participant to seek additional follow-up and/or medical evaluation. Physical performance testing will be deferred until consultation with the study clinician. \\\\\n\\hline \\begin{tabular}{l}\nResting blood pressure or after SMWT \\\\\nSBP \\(>185 mm\\) Hg or SBP \\(<90 mm\\) Hg or DBP \\(>110 mm Hg\\) or DBP \\(<50 mm Hg\\)\n\\end{tabular} & Qualified staff will consult with the study clinician and follow up as needed. \\\\\n\\hline \\begin{tabular}{l}\nResting pulse \\\\\nRate > 120 or < 40 beats/min\n\\end{tabular} & Qualified staff will consult with the study clinician and follow up as needed. \\\\\n\\hline Chest pain, dizziness, significant shortness of breath, or severe musculoskeletal pain during the intervention or study assessment. & Qualified staff will consult with the study clinician and follow up as needed. \\\\\n\\hline \\begin{tabular}{l}\nCES-D \\\\\nScore \\(\\geq 27\\)\n\\end{tabular} & Qualified staff will talk to the participant and provide a referral for additional follow-up and/or medical evaluation for depression. \\\\\n\\hline Weight loss \\(\\geq 2 \\%\\) in four weeks during intervention period & Participant will be referred to the registered dietician for follow-up by telephone. \\\\\n\\hline Weight not obtained at the final PT intervention visit and there is weight loss \\(\\geq 5 \\%\\) between baseline and follow-up. & Clinical site PI or clinical site clinician will review participant's weight trajectory, baseline BMI, baseline MNA®-SF score and registered dietician's documentation and, if warranted, will refer the participant to a dietician or medical provider for follow-up of possible poor nutritional status. \\\\\n\\hline Participant expresses desire to commit suicide & Call primary care provider and report findings. Report to clinical site coordinator/study clinician for follow-up and clearance. 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Report to clinical site coordinator/study clinician for follow-up and clearance.","text_display":"Call primary care provider and report findings. Report to clinical site coordinator/study clinician for follow-up and clearance.","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1022,1634],[1646,1634],[1646,1675],[1022,1675]],"region":{"top_left_x":1021,"top_left_y":1634,"width":626,"height":42},"line":84,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5559d2ab7e844b52a926e10dd0bd2113","type":"text","conversion_output":false,"parent_id":"a8de23bb8dcd4af4834d2256c87d8245","text":"Call primary care provider and report","text_display":"Call primary care provider and report","confidence":1,"confidence_rate":1},{"cnt":[[1019,1678],[1526,1678],[1526,1719],[1019,1719]],"region":{"top_left_x":1018,"top_left_y":1677,"width":509,"height":42},"line":85,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"115e43f1592241fb9018eb089f800265","type":"text","conversion_output":false,"parent_id":"a8de23bb8dcd4af4834d2256c87d8245","text":"findings. Report to clinical site","text_display":" findings. Report to clinical site","confidence":1,"confidence_rate":1},{"cnt":[[1022,1722],[1756,1722],[1756,1763],[1022,1763]],"region":{"top_left_x":1021,"top_left_y":1721,"width":735,"height":42},"line":86,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a57fc0b4b715430caeeaad8029d7b836","type":"text","conversion_output":false,"parent_id":"a8de23bb8dcd4af4834d2256c87d8245","text":"coordinator/study clinician for follow-up and","text_display":" coordinator/study clinician for follow-up and","confidence":1,"confidence_rate":1},{"cnt":[[1022,1765],[1199,1765],[1199,1801],[1022,1801]],"region":{"top_left_x":1021,"top_left_y":1765,"width":179,"height":36},"line":87,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"863a9a966335491d9b61965abbebbcff","type":"text","conversion_output":false,"parent_id":"a8de23bb8dcd4af4834d2256c87d8245","text":"clearance.","text_display":" clearance.","confidence":1,"confidence_rate":1},{"cnt":[[370,1848],[1386,1848],[1386,1901],[370,1901]],"region":{"top_left_x":369,"top_left_y":1847,"width":1017,"height":55},"line":88,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67a9e460a0714d84a493450868beb305","type":"section_header","conversion_output":false,"children_ids":["0858ea8575f543769c2f648ed133ee74"],"text":"","text_display":""},{"cnt":[[374,1852],[1381,1852],[1381,1897],[374,1897]],"region":{"top_left_x":373,"top_left_y":1851,"width":1009,"height":47},"line":89,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0858ea8575f543769c2f648ed133ee74","type":"text","conversion_output":true,"parent_id":"67a9e460a0714d84a493450868beb305","text":"12.1.3 Safety Considerations for the PUSH Intervention","text_display":"\n\n\\subsection*{12.1.3 Safety Considerations for the PUSH Intervention}","confidence":0.9956073760986328,"confidence_rate":0.999925387532475},{"cnt":[[245,1895],[1876,1895],[1876,1942],[245,1942]],"region":{"top_left_x":244,"top_left_y":1894,"width":1632,"height":49},"line":90,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52eb0e87307d49acbf084447a708de31","type":"text","conversion_output":true,"text":"There is no expectation that the PUSH intervention will evoke serious cardiovascular responses;","text_display":"\n\nThere is no expectation that the PUSH intervention will evoke serious cardiovascular responses;","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1938],[1846,1938],[1846,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1937,"width":1602,"height":51},"line":91,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f0e4b08185e439aaf59004af451517c","type":"text","conversion_output":true,"text":"however, participants will be warned of a possible risk. Cardiac events are rare, with estimates","text_display":" however, participants will be warned of a possible risk. Cardiac events are rare, with estimates","confidence":1,"confidence_rate":1},{"cnt":[[245,1981],[1760,1981],[1760,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1980,"width":1516,"height":51},"line":92,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbdf7a7c0a1f444e800425b2dd4d75b1","type":"text","conversion_output":true,"text":"of one event per 60,000 participant-hours in aerobic exercise programs. \\({ }^{200}\\) No significant","text_display":" of one event per 60,000 participant-hours in aerobic exercise programs. \\({ }^{200}\\) No significant","confidence":0.98681640625,"confidence_rate":0.9998771254315891},{"cnt":[[245,2024],[1824,2024],[1824,2075],[245,2075]],"region":{"top_left_x":244,"top_left_y":2023,"width":1581,"height":53},"line":93,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea212af3cfd7460193efc54b29349f62","type":"text","conversion_output":true,"text":"cardiac events were reported after performing 1-RM testing for over 6600 healthy subjects. \\({ }^{201}\\)","text_display":" cardiac events were reported after performing 1-RM testing for over 6600 healthy subjects. \\({ }^{201}\\)","confidence":0.96435546875,"confidence_rate":0.9996639887901174},{"cnt":[[245,2071],[1841,2071],[1841,2121],[245,2121]],"region":{"top_left_x":244,"top_left_y":2071,"width":1598,"height":50},"line":94,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6677334abec44955b36ce689cc388114","type":"text","conversion_output":true,"text":"The American Heart Association's guidelines for resistance training for adults with and without","text_display":" The American Heart Association's guidelines for resistance training for adults with and without","confidence":1,"confidence_rate":1},{"cnt":[[245,2114],[1781,2114],[1781,2163],[245,2163]],"region":{"top_left_x":244,"top_left_y":2114,"width":1538,"height":50},"line":95,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"218e1f9c8f0c4fb6a0c048794f1744b0","type":"text","conversion_output":true,"text":"cardiovascular disease reports the safety of high intensity resistance training and testing in","text_display":" cardiovascular disease reports the safety of high intensity resistance training and testing in","confidence":1,"confidence_rate":1},{"cnt":[[245,2159],[1796,2159],[1796,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2159,"width":1553,"height":48},"line":96,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62974686438f4644b1a332793df1f411","type":"text","conversion_output":true,"text":"persons with coronary disease which found an absence of anginal symptoms, ischemic ST-","text_display":" persons with coronary disease which found an absence of anginal symptoms, ischemic ST","confidence":1,"confidence_rate":1},{"cnt":[[245,2204],[1717,2204],[1717,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2204,"width":1473,"height":46},"line":97,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75e14c5f5bb9467b86274a7c56eb0b68","type":"text","conversion_output":true,"text":"segment depression, abnormal hemodynamics, complex ventricular dysrhythmias, and","text_display":"segment depression, abnormal hemodynamics, complex ventricular dysrhythmias, and","confidence":1,"confidence_rate":1},{"cnt":[[245,2245],[1710,2245],[1710,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2245,"width":1467,"height":52},"line":98,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88dd456b8b31418fa863be31ee374c07","type":"text","conversion_output":true,"text":"cardiovascular complications. \\({ }^{202,203}\\) Less serious risks may include chest pain, fainting,","text_display":" cardiovascular complications. \\({ }^{202,203}\\) Less serious risks may include chest pain, fainting,","confidence":1,"confidence_rate":1},{"cnt":[[245,2290],[1699,2290],[1699,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2290,"width":1456,"height":50},"line":99,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0763e7f1a06d44e8a39fca50e30382af","type":"text","conversion_output":true,"text":"hypotension, or muscle strain. We have minimized risk to participants by following the","text_display":" hypotension, or muscle strain. We have minimized risk to participants by following the","confidence":1,"confidence_rate":1},{"cnt":[[245,2333],[1824,2333],[1824,2383],[245,2383]],"region":{"top_left_x":244,"top_left_y":2333,"width":1581,"height":50},"line":100,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d01ef7440b74a8da3a2d6838319c4c7","type":"text","conversion_output":true,"text":"guidelines suggested by Gill et al. \\({ }^{199}\\) Blood pressure and heart rate will be monitored using a","text_display":" guidelines suggested by Gill et al. \\({ }^{199}\\) Blood pressure and heart rate will be monitored using a","confidence":1,"confidence_rate":1},{"cnt":[[245,2380],[1313,2380],[1313,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2380,"width":1069,"height":46},"line":101,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e68eb19f4a04464b88a3b089c54a9ae2","type":"text","conversion_output":true,"text":"standard blood pressure cuff and palpation of peripheral pulse.","text_display":" standard blood pressure cuff and palpation of peripheral pulse.","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac939fa318d440778f28cd71246af084","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1833,2587],[1882,2587],[1882,2625],[1833,2625]],"region":{"top_left_x":1832,"top_left_y":2586,"width":51,"height":40},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b13d1257800482687b96c74d88d7854","type":"page_info","conversion_output":false,"text":"44","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-064","page":64,"lines":[{"cnt":[[245,249],[1876,249],[1876,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1632,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"286c5325d63f465586fe670a2cf9a4c5","type":"text","conversion_output":true,"text":"Another concern is the presence of osteoporosis and the risk of inducing a compression fracture","text_display":"\n\nAnother concern is the presence of osteoporosis and the risk of inducing a compression fracture","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1846,296],[1846,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1602,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c092c6627cc1479da76a4367e43f8a66","type":"text","conversion_output":true,"text":"or a lower extremity fracture. The exercises have been designed to minimize this risk. The risk","text_display":" or a lower extremity fracture. The exercises have been designed to minimize this risk. The risk","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1820,339],[1820,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1576,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95fa5539d4dc422e9a6e95afd0265be2","type":"text","conversion_output":true,"text":"of inducing a compression fracture will be minimized because the exercises are performed in","text_display":" of inducing a compression fracture will be minimized because the exercises are performed in","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1876,382],[1876,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1632,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"621c24005aeb4fffaa9b7353e504079e","type":"text","conversion_output":true,"text":"supine and upright standing positions with minimal to no trunk flexion. \\({ }^{204}\\) The PT will also remind","text_display":" supine and upright standing positions with minimal to no trunk flexion. \\({ }^{204}\\) The PT will also remind","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,425],[1846,425],[1846,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1602,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3eaa07d696dd4f33a64ba508cf81d4d7","type":"text","conversion_output":true,"text":"the participant to minimize flexion to the spine during all standing exercises. Using an exercise","text_display":" the participant to minimize flexion to the spine during all standing exercises. Using an exercise","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1824,473],[1824,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1581,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d94cd6d65af4f3ea25db3f1fb5dc52f","type":"text","conversion_output":true,"text":"device that eliminates the risk of weights falling on a person, and using only voluntary muscle","text_display":" device that eliminates the risk of weights falling on a person, and using only voluntary muscle","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1846,516],[1846,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1602,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"867b01c310624792aa547225391792f7","type":"text","conversion_output":true,"text":"contractions during isometric testing, will reduce the risk of lower extremity fracture. We do not","text_display":" contractions during isometric testing, will reduce the risk of lower extremity fracture. 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Delayed onset muscle soreness is a common occurrence","text_display":" load than walking up and down stairs. Delayed onset muscle soreness is a common occurrence","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1803,778],[1803,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1559,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef84d2319228428cb0b79bfddd9263fb","type":"text","conversion_output":true,"text":"after the initiation of an exercise program. The soreness occurs in the muscle belly \\(1-3\\) days","text_display":" after the initiation of an exercise program. The soreness occurs in the muscle belly \\(1-3\\) days","confidence":0.9970729344058782,"confidence_rate":0.9999709770763372},{"cnt":[[245,821],[1846,821],[1846,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1602,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b7bfa358d01408ca466e73af22ede0e","type":"text","conversion_output":true,"text":"after the initiation of exercise and lasts \\(2-3\\) days. There is no effective way to eliminate the risk","text_display":" after the initiation of exercise and lasts \\(2-3\\) days. There is no effective way to eliminate the risk","confidence":0.7331700325012207,"confidence_rate":0.9971302586021752},{"cnt":[[245,868],[1772,868],[1772,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1529,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fdeee4c1e1f4a65850c99845cc79342","type":"text","conversion_output":true,"text":"of delayed onset muscle soreness, but it is hoped that the orientation process and gradual","text_display":" of delayed onset muscle soreness, but it is hoped that the orientation process and gradual","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1824,911],[1824,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1581,"height":47},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23a561a8e1d14d6782599781c5327388","type":"text","conversion_output":true,"text":"increase in intensity will reduce the risk. The participants will be informed about the condition,","text_display":" increase in intensity will reduce the risk. The participants will be informed about the condition,","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1871,954],[1871,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1628,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30fbc5cd5b6c43338f9a24f67468d6a5","type":"text","conversion_output":true,"text":"what it feels like, how long it lasts, and suggested ways of decreasing the pain including the use","text_display":" what it feels like, how long it lasts, and suggested ways of decreasing the pain including the use","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1798,997],[1798,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1555,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b389710eeec427db1af2e7b48a5a747","type":"text","conversion_output":true,"text":"of superficial heat or ice. If a participant reports continued discomfort, the study clinician will","text_display":" of superficial heat or ice. If a participant reports continued discomfort, the study clinician will","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1807,1042],[1807,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1563,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb45ec29b060466691e88b55c7e364e0","type":"text","conversion_output":true,"text":"discuss this with the participant and contact their primary care provider (PCP) as necessary.","text_display":" discuss this with the participant and contact their primary care provider (PCP) as necessary.","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1725,1087],[1725,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1482,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4cdf38b15e1f4de7b13d8d5121001b71","type":"text","conversion_output":true,"text":"Please see Table 3 below for a summary of alerts and appropriate action during the PT","text_display":" Please see Table 3 below for a summary of alerts and appropriate action during the PT","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,1130],[556,1130],[556,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1130,"width":313,"height":41},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fcbeaddddde4b549525c1474911c741","type":"text","conversion_output":true,"text":"intervention visits.","text_display":" intervention visits.","confidence":0.9990234375,"confidence_rate":0.9999609191777622},{"cnt":[[367,1212],[1354,1212],[1354,1265],[367,1265]],"region":{"top_left_x":367,"top_left_y":1211,"width":987,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b50b59b869cb44ac943fe155c022c0e4","type":"section_header","conversion_output":false,"children_ids":["490adb087ad9495aa8557a426603de58"],"text":"","text_display":""},{"cnt":[[374,1216],[1349,1216],[1349,1261],[374,1261]],"region":{"top_left_x":373,"top_left_y":1216,"width":977,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"490adb087ad9495aa8557a426603de58","type":"text","conversion_output":true,"parent_id":"b50b59b869cb44ac943fe155c022c0e4","text":"12.1.4 Safety Measures during the PUSH Intervention","text_display":"\n\n\\subsection*{12.1.4 Safety Measures during the PUSH Intervention}","confidence":1,"confidence_rate":1},{"cnt":[[245,1261],[1869,1261],[1869,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1261,"width":1626,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbc579bab2764cceb00c38683cb7f562","type":"text","conversion_output":true,"text":"The PUSH intervention will be conducted in the participant's place of residence and all sessions","text_display":"\n\nThe PUSH intervention will be conducted in the participant's place of residence and all sessions","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1820,1306],[1820,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1576,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d90b68a254d74b7fbe0d439aa13c3b75","type":"text","conversion_output":true,"text":"will be conducted and supervised by trained PTs, who monitor potential adverse experiences","text_display":" will be conducted and supervised by trained PTs, who monitor potential adverse experiences","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1772,1349],[1772,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1349,"width":1529,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92cffc9e84224211abc55f03b425aa88","type":"text","conversion_output":true,"text":"and symptoms. PTs will be trained to deal with medical emergencies that occur during the","text_display":" and symptoms. PTs will be trained to deal with medical emergencies that occur during the","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[1807,1392],[1807,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1563,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da8fb2d039f54a36a00024e2961e9484","type":"text","conversion_output":true,"text":"PUSH sessions and will be CPR certified. Also, community EMS services will be activated if","text_display":" PUSH sessions and will be CPR certified. Also, community EMS services will be activated if","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[389,1439],[389,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1439,"width":145,"height":42},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e446809e611d4c5b9a9b4b82d9f41c7b","type":"text","conversion_output":true,"text":"needed.","text_display":" needed.","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1772,1525],[1772,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1529,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c6b735795a64abfb79438cf569d2469","type":"text","conversion_output":true,"text":"In order to minimize discomfort and maximize safety, participants will be taught the proper","text_display":"\n\nIn order to minimize discomfort and maximize safety, participants will be taught the proper","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1747,1568],[1747,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1503,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3f91c93bce54d1bba189792a2174951","type":"text","conversion_output":true,"text":"method for performing each exercise and the importance of following the proper method.","text_display":" method for performing each exercise and the importance of following the proper method.","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1852,1611],[1852,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1608,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3114c8b63fbf480a868421380556728e","type":"text","conversion_output":true,"text":"Intensity is gradually increased, and exercise technique is commented on during each session.","text_display":" Intensity is gradually increased, and exercise technique is commented on during each session.","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1695,1659],[1695,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1452,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cf75b485cef4ab29467c04742fa23e2","type":"text","conversion_output":true,"text":"Participants will be instructed to talk with the PTs about any muscle soreness, pain or","text_display":" Participants will be instructed to talk with the PTs about any muscle soreness, pain or","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[440,1702],[440,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1701,"width":197,"height":42},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"027c75f024924f08b3c8d218b2edddb8","type":"text","conversion_output":true,"text":"discomfort.","text_display":" discomfort.","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1846,1788],[1846,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1602,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cc0ec3672db4f26aae410f5716e82cd","type":"text","conversion_output":true,"text":"Every effort will be made to prevent harm by stopping intervention activity when the participant","text_display":"\n\nEvery effort will be made to prevent harm by stopping intervention activity when the participant","confidence":1,"confidence_rate":1},{"cnt":[[245,1833],[1820,1833],[1820,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1832,"width":1576,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4a46db887ca44e4bd03f974290ebbc3","type":"text","conversion_output":true,"text":"reports chest pain, dizziness, significant shortness of breath, or severe musculoskeletal pain.","text_display":" reports chest pain, dizziness, significant shortness of breath, or severe musculoskeletal pain.","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1772,1878],[1772,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1877,"width":1529,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdf1dca62f6d458f808d4921b629601d","type":"text","conversion_output":true,"text":"PTs will monitor blood pressure at the start of the training session, mid-session, and when","text_display":" PTs will monitor blood pressure at the start of the training session, mid-session, and when","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1865,1921],[1865,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1621,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6759429084114d79af1a5fd6e013d4fd","type":"text","conversion_output":true,"text":"participants are finished with the session. Blood pressure and heart rate will be monitored using","text_display":" participants are finished with the session. Blood pressure and heart rate will be monitored using","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1833,1964],[1833,2011],[245,2011]],"region":{"top_left_x":244,"top_left_y":1963,"width":1589,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee9b45d71396430bbe05cc89d0189ad6","type":"text","conversion_output":true,"text":"a standard blood pressure cuff and palpation of peripheral pulse. If blood pressure is elevated","text_display":" a standard blood pressure cuff and palpation of peripheral pulse. If blood pressure is elevated","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1740,2007],[1740,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1497,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d22eb60ad8c1478ab464474de97ebb55","type":"text","conversion_output":true,"text":"above \\(170 / 100\\), the participant will rest quietly for a few minutes. The PT will monitor the","text_display":" above \\(170 / 100\\), the participant will rest quietly for a few minutes. The PT will monitor the","confidence":0.5226709954440594,"confidence_rate":0.9935329709806736},{"cnt":[[245,2054],[1751,2054],[1751,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2053,"width":1507,"height":47},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27b0058a8ad844af954979d23eeb7509","type":"text","conversion_output":true,"text":"participant for signs of muscle strain, dizziness, or hypotension and appropriate palliative","text_display":" participant for signs of muscle strain, dizziness, or hypotension and appropriate palliative","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1850,2097],[1850,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1606,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc9ba12715414c53b3ab986e411f14a1","type":"text","conversion_output":true,"text":"methods will be discussed with the participants and appropriate medical referrals will be made.","text_display":" methods will be discussed with the participants and appropriate medical referrals will be made.","confidence":1,"confidence_rate":1},{"cnt":[[367,2179],[1407,2179],[1407,2232],[367,2232]],"region":{"top_left_x":367,"top_left_y":2178,"width":1041,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8c3dd70a5c0480eac7ccd7bffd2f038","type":"section_header","conversion_output":false,"children_ids":["9e77667ffd5f4c40a55378409d030d29"],"text":"","text_display":""},{"cnt":[[374,2183],[1403,2183],[1403,2228],[374,2228]],"region":{"top_left_x":373,"top_left_y":2182,"width":1030,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e77667ffd5f4c40a55378409d030d29","type":"text","conversion_output":true,"parent_id":"a8c3dd70a5c0480eac7ccd7bffd2f038","text":"12.1.5 Safety Considerations for the PULSE Intervention","text_display":"\n\n\\subsection*{12.1.5 Safety Considerations for the PULSE Intervention}","confidence":0.9921875,"confidence_rate":0.9998692889190874},{"cnt":[[245,2228],[1876,2228],[1876,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2227,"width":1632,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a2444713ea4480f86e1cc90b761cd76","type":"text","conversion_output":true,"text":"TENS is generally considered safe. However, electrical current that is too intense or that is used","text_display":"\n\nTENS is generally considered safe. However, electrical current that is too intense or that is used","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1777,2273],[1777,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1533,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2c87df7a08e4825a015e4ab232c54a4","type":"text","conversion_output":true,"text":"incorrectly can burn or irritate the skin. The electrodes should not be placed over the eyes,","text_display":" incorrectly can burn or irritate the skin. The electrodes should not be placed over the eyes,","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1807,2316],[1807,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":1563,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"168fa5dcdbf74be184b74ef3f8d4c3ac","type":"text","conversion_output":true,"text":"heart, brain, or front of the throat. Electrodes should not be placed over the chest of persons","text_display":" heart, brain, or front of the throat. Electrodes should not be placed over the chest of persons","confidence":1,"confidence_rate":1},{"cnt":[[245,2406],[245,2359],[1858,2361],[1858,2408]],"region":{"top_left_x":244,"top_left_y":2358,"width":1615,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7598ff56bc79481d9d5aa0ece978a6c7","type":"text","conversion_output":true,"text":"with demand-inhibited synchronous pace makers. People with allergies to adhesives may react","text_display":" with demand-inhibited synchronous pace makers. People with allergies to adhesives may react","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1837,2402],[1837,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1593,"height":51},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1494c972f3054064b98b6a86231c1559","type":"text","conversion_output":true,"text":"to the electrode pads. If the participant is allergic to adhesives, carbon electrodes with gel and","text_display":" to the electrode pads. If the participant is allergic to adhesives, carbon electrodes with gel and","confidence":1,"confidence_rate":1},{"cnt":[[245,2449],[1691,2449],[1691,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2449,"width":1447,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4289796c0694ab0a01992c254cc9744","type":"text","conversion_output":true,"text":"non-allergenic skin tape will be used. Skin tears may occur when removing the pads.","text_display":" non-allergenic skin tape will be used. Skin tears may occur when removing the pads.","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83abf49d305c491cad77e795ff352927","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1830,2587],[1882,2587],[1882,2625],[1830,2625]],"region":{"top_left_x":1830,"top_left_y":2586,"width":53,"height":40},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85facb01cd6c4a779fad6255aa7ba4ab","type":"page_info","conversion_output":false,"text":"45","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-065","page":65,"lines":[{"cnt":[[245,251],[1760,251],[1760,299],[245,299]],"region":{"top_left_x":244,"top_left_y":251,"width":1516,"height":48},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"235add458f4741e8bbeb6a54085bb0fa","type":"text","conversion_output":true,"text":"Participants may experience tingling or numbness that only lasts when the electrodes are","text_display":"\n\nParticipants may experience tingling or numbness that only lasts when the electrodes are","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1837,296],[1837,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1593,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"145d9e73e6814e52b7159d6c89a57f76","type":"text","conversion_output":true,"text":"delivering current. Those with implanted pacemakers, defibrillators, infusion pumps, and other","text_display":" delivering current. Those with implanted pacemakers, defibrillators, infusion pumps, and other","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1798,339],[1798,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1555,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4992c0d5e6c413981c4bfa73409e8f8","type":"text","conversion_output":true,"text":"such devices should not have current passing over the body areas where these devices are","text_display":" such devices should not have current passing over the body areas where these devices are","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1833,382],[1833,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1589,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45b0e67100d845d98a4e991abcc2b8e8","type":"text","conversion_output":true,"text":"located. This should not be a problem in this study since the electrode placements are not on","text_display":" located. This should not be a problem in this study since the electrode placements are not on","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1820,430],[1820,475],[245,475]],"region":{"top_left_x":244,"top_left_y":429,"width":1576,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d7ccb756e3143919f61b6e265084733","type":"text","conversion_output":true,"text":"the upper body and are restricted to targeted muscle groups on the lower extremities. Please","text_display":" the upper body and are restricted to targeted muscle groups on the lower extremities. Please","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1798,473],[1798,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1555,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"968c7839938f4394a8aaf22f138c7878","type":"text","conversion_output":true,"text":"see Table 3 for a summary of alerts and appropriate action during the PT intervention visits.","text_display":" see Table 3 for a summary of alerts and appropriate action during the PT intervention visits.","confidence":0.9985356330871582,"confidence_rate":0.9999854907968839},{"cnt":[[245,559],[1182,559],[1182,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":938,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"698634b595984defbb3d54d41aeee5fc","type":"figure_label","conversion_output":false,"text":"Table 3. Safety Alerts and Actions for Interventions","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999914316069175},{"cnt":[[226,597],[1800,597],[1800,2243],[226,2243]],"region":{"top_left_x":225,"top_left_y":597,"width":1576,"height":1646},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efe95c92637f40309ba8d6c060b17f9a","type":"table","conversion_output":true,"children_ids":["a2472f7011c74c0b83123845c0638030","43fdf39c2c0b4541b2e2480a3e0ab793","82ab4bd35f8b4af990c63eea61a27d0c","cdb657a0080d4c7a80e746c33613a77d","5a7d11e06cb44de0bc5bacf79cc54cdd","b31681fc819c4cc6b68d1a19b463a3aa","7792dc552dbf47618cb9972c626a74a3","11d93f39180f49e694e97386ce0a4745","be27651ef8d3406d9d4802616b2a1354","670c6b47de6743599162ff6c664f47d1","a0a7367e9dc74a64ae4a4fc897b6daa7","bbc9e5608f804fb99e2040b38007bf13","79b14faef1ca469a8f84afc0352c7027","e5ba81f740954bfabd14b83972b391cb","b1e8b684a0a04670af9bac69ae802dd4","11881a8eef96496695535090bfcd803c","b1987f52bea442fa830f70cb4ede77b4","1c1d7bb0b4214a65ade9bafe21844e65","5095e45ee59c44c78e4430b2577f7af6","e478abecb9f24ff18846fc82347bbac2"],"selected_labels":["698634b595984defbb3d54d41aeee5fc"],"text":"\\begin{tabular}{|l|l|}\n\\hline ALERT & ACTION \\\\\n\\hline Resting blood pressure SBP \\(>170 mm Hg\\) or SBP \\(<90 mm\\) Hg or DBP \\(>100 mm Hg\\) or DBP \\(<50 mm Hg\\) & \\begin{tabular}{l}\n1. If initial BP check is high (systolic > 170; diastolic >100), have participant sit for 5 minutes and rest then check BP again. This may be done twice. \\\\\n2. If three BP readings are greater than 170/100, then individual should not exercise. \\\\\n3. The PCP, clinical site coordinator, and study clinician should be called before exercise is initiated. \\\\\n4. If initial BP is low for that person (systolic<90; diastolic<50) follow same protocol.\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nNew chest pain \\\\\nReported chest pain that occurred between visits\n\\end{tabular} & \\begin{tabular}{l}\nCall 911. \\\\\n1. Cancel treatment and call PCP. \\\\\n2. Report to clinical site coordinator and study clinician to follow-up until cleared.\n\\end{tabular} \\\\\n\\hline Acute shortness of breath & \\begin{tabular}{l}\n1. Have participant stop exercising and rest. \\\\\n2. Take vital signs. \\\\\n3. If the shortness of breath does not resolve itself in 10 minutes, and vital signs are not within normal limits for participant, call 911. \\\\\n4. Report to PCP, clinical site coordinator, and study clinician.\n\\end{tabular} \\\\\n\\hline Fall & \\begin{tabular}{l}\n1. If there is bleeding/wound, apply pressure using emergency kit for wound; call 911 if needed. If participant is unable to stand or move the injured part, call 911 and keep them warm and comfortable. \\\\\n2. Report all falls to clinical site coordinator. \\\\\n3. Complete an incident report.\n\\end{tabular} \\\\\n\\hline Stroke symptoms & Call 911 immediately. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3. Safety Alerts and Actions for Interventions}\n\\begin{tabular}{|l|l|}\n\\hline ALERT & ACTION \\\\\n\\hline Resting blood pressure SBP \\(>170 mm Hg\\) or SBP \\(<90 mm\\) Hg or DBP \\(>100 mm Hg\\) or DBP \\(<50 mm Hg\\) & \\begin{tabular}{l}\n1. If initial BP check is high (systolic > 170; diastolic >100), have participant sit for 5 minutes and rest then check BP again. This may be done twice. \\\\\n2. If three BP readings are greater than 170/100, then individual should not exercise. \\\\\n3. The PCP, clinical site coordinator, and study clinician should be called before exercise is initiated. \\\\\n4. If initial BP is low for that person (systolic<90; diastolic<50) follow same protocol.\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nNew chest pain \\\\\nReported chest pain that occurred between visits\n\\end{tabular} & \\begin{tabular}{l}\nCall 911. \\\\\n1. Cancel treatment and call PCP. \\\\\n2. Report to clinical site coordinator and study clinician to follow-up until cleared.\n\\end{tabular} \\\\\n\\hline Acute shortness of breath & \\begin{tabular}{l}\n1. Have participant stop exercising and rest. \\\\\n2. Take vital signs. \\\\\n3. If the shortness of breath does not resolve itself in 10 minutes, and vital signs are not within normal limits for participant, call 911. \\\\\n4. Report to PCP, clinical site coordinator, and study clinician.\n\\end{tabular} \\\\\n\\hline Fall & \\begin{tabular}{l}\n1. If there is bleeding/wound, apply pressure using emergency kit for wound; call 911 if needed. If participant is unable to stand or move the injured part, call 911 and keep them warm and comfortable. \\\\\n2. Report all falls to clinical site coordinator. \\\\\n3. Complete an incident report.\n\\end{tabular} \\\\\n\\hline Stroke symptoms & Call 911 immediately. \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.59619140625,"confidence_rate":0.9997506175541792},{"cnt":[[236,597],[994,597],[994,2242],[236,2242]],"region":{"top_left_x":235,"top_left_y":597,"width":760,"height":1646},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2472f7011c74c0b83123845c0638030","type":"table_column","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"","text_display":""},{"cnt":[[1005,597],[1783,597],[1783,2242],[1005,2242]],"region":{"top_left_x":1005,"top_left_y":597,"width":778,"height":1646},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43fdf39c2c0b4541b2e2480a3e0ab793","type":"table_column","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"","text_display":""},{"cnt":[[225,602],[1802,602],[1802,649],[225,649]],"region":{"top_left_x":225,"top_left_y":602,"width":1577,"height":47},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82ab4bd35f8b4af990c63eea61a27d0c","type":"table_row","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"","text_display":""},{"cnt":[[225,646],[1802,646],[1802,1227],[225,1227]],"region":{"top_left_x":225,"top_left_y":646,"width":1577,"height":582},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdb657a0080d4c7a80e746c33613a77d","type":"table_row","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"","text_display":""},{"cnt":[[225,1219],[1802,1219],[1802,1446],[225,1446]],"region":{"top_left_x":225,"top_left_y":1219,"width":1577,"height":227},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a7d11e06cb44de0bc5bacf79cc54cdd","type":"table_row","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"","text_display":""},{"cnt":[[225,1440],[1802,1440],[1802,1844],[225,1844]],"region":{"top_left_x":225,"top_left_y":1440,"width":1577,"height":404},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b31681fc819c4cc6b68d1a19b463a3aa","type":"table_row","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"","text_display":""},{"cnt":[[225,1836],[1802,1836],[1802,2199],[225,2199]],"region":{"top_left_x":225,"top_left_y":1835,"width":1577,"height":364},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7792dc552dbf47618cb9972c626a74a3","type":"table_row","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"","text_display":""},{"cnt":[[225,2190],[1802,2190],[1802,2242],[225,2242]],"region":{"top_left_x":225,"top_left_y":2190,"width":1577,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11d93f39180f49e694e97386ce0a4745","type":"table_row","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"","text_display":""},{"cnt":[[247,608],[375,608],[375,643],[247,643]],"region":{"top_left_x":246,"top_left_y":607,"width":130,"height":37},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be27651ef8d3406d9d4802616b2a1354","type":"simple_cell","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"ALERT","text_display":"ALERT","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1016,602],[1166,602],[1166,643],[1016,643]],"region":{"top_left_x":1016,"top_left_y":602,"width":151,"height":42},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"670c6b47de6743599162ff6c664f47d1","type":"simple_cell","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","text":"ACTION","text_display":"ACTION","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[241,649],[953,649],[953,788],[241,788]],"region":{"top_left_x":241,"top_left_y":648,"width":713,"height":140},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0a7367e9dc74a64ae4a4fc897b6daa7","type":"complex_cell","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","children_ids":["20bc4a1a08d04f8798ecf699a16ea1c2","608b886f747a4edc8e967184ab173d5c","b45f2c47fdf84d218e41df976e7e26b2"],"text":"Resting blood pressure SBP \\(>170 mm Hg\\) or SBP \\(<90 mm\\) Hg or DBP \\(>100 mm Hg\\) or DBP \\(<50 mm Hg\\)","text_display":"Resting blood pressure SBP \\(>170 mm Hg\\) or SBP \\(<90 mm\\) Hg or DBP \\(>100 mm Hg\\) or DBP \\(<50 mm Hg\\)","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.7232019589282572,"confidence_rate":0.9977901571264994},{"cnt":[[247,652],[648,652],[648,698],[247,698]],"region":{"top_left_x":246,"top_left_y":651,"width":402,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20bc4a1a08d04f8798ecf699a16ea1c2","type":"text","conversion_output":false,"parent_id":"a0a7367e9dc74a64ae4a4fc897b6daa7","text":"Resting blood pressure","text_display":"Resting blood pressure","confidence":1,"confidence_rate":1},{"cnt":[[247,695],[948,695],[948,739],[247,739]],"region":{"top_left_x":246,"top_left_y":695,"width":703,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"608b886f747a4edc8e967184ab173d5c","type":"text","conversion_output":false,"parent_id":"a0a7367e9dc74a64ae4a4fc897b6daa7","text":"SBP \\(>170 mm Hg\\) or SBP \\(<90 mm\\) Hg or","text_display":" SBP \\(>170 mm Hg\\) or SBP \\(<90 mm\\) Hg or","confidence":0.7232019589282572,"confidence_rate":0.9934082143961739},{"cnt":[[247,739],[904,739],[904,785],[247,785]],"region":{"top_left_x":246,"top_left_y":738,"width":659,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b45f2c47fdf84d218e41df976e7e26b2","type":"text","conversion_output":false,"parent_id":"a0a7367e9dc74a64ae4a4fc897b6daa7","text":"DBP \\(>100 mm Hg\\) or DBP \\(<50 mm Hg\\)","text_display":" DBP \\(>100 mm Hg\\) or DBP \\(<50 mm Hg\\)","confidence":0.9990236759185791,"confidence_rate":0.9999767431038692},{"cnt":[[1011,646],[1769,646],[1769,1222],[1011,1222]],"region":{"top_left_x":1010,"top_left_y":646,"width":760,"height":576},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbc9e5608f804fb99e2040b38007bf13","type":"complex_cell","conversion_output":false,"parent_id":"efe95c92637f40309ba8d6c060b17f9a","children_ids":["9bf83f3e425d48bfbf36ec93e16f0475","e667834737da48dea67570b5d6b4aff2","0ffa7e5f9a444507a5dc8d51ad21fd77","31bb7c0e70ba46798fe85c582fcb4499","e18257d067c447beb367857b7118295f","3083fc263c04400e9026c45819a89792","3fff9e5f991d45d4ab3c039540c7b15f","fd1b153d84af40a0a8054fcc10822086","842e324cea424f78b52d8e78ae7b6ea1","918ec89318074c75a083954714cb7d1c","0260622bd5a54087ae2d5b09f937ac31","bf8b0f263c2843c893795937ab316f01","e161210abea64f92a0fada7b93aded27"],"text":"\\begin{tabular}{l}\n1. If initial BP check is high (systolic > 170; diastolic >100), have participant sit for 5 minutes and rest then check BP again. This may be done twice. \\\\\n2. If three BP readings are greater than 170/100, then individual should not exercise. \\\\\n3. The PCP, clinical site coordinator, and study clinician should be called before exercise is initiated. \\\\\n4. If initial BP is low for that person (systolic<90; diastolic<50) follow same protocol.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n1. If initial BP check is high (systolic > 170; diastolic >100), have participant sit for 5 minutes and rest then check BP again. This may be done twice. \\\\\n2. If three BP readings are greater than 170/100, then individual should not exercise. \\\\\n3. The PCP, clinical site coordinator, and study clinician should be called before exercise is initiated. \\\\\n4. If initial BP is low for that person (systolic<90; diastolic<50) follow same protocol.\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.59619140625,"confidence_rate":0.9992196302648599},{"cnt":[[1016,652],[1764,652],[1764,698],[1016,698]],"region":{"top_left_x":1016,"top_left_y":651,"width":748,"height":47},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bf83f3e425d48bfbf36ec93e16f0475","type":"text","conversion_output":false,"parent_id":"bbc9e5608f804fb99e2040b38007bf13","text":"1. If initial BP check is high (systolic > 170;","text_display":"1. If initial BP check is high (systolic > 170;","confidence":0.59619140625,"confidence_rate":0.990103269093625},{"cnt":[[1079,695],[1761,695],[1761,739],[1079,739]],"region":{"top_left_x":1078,"top_left_y":695,"width":684,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e667834737da48dea67570b5d6b4aff2","type":"text","conversion_output":false,"parent_id":"bbc9e5608f804fb99e2040b38007bf13","text":"diastolic >100), have participant sit for 5","text_display":" diastolic >100), have participant sit for 5","confidence":0.9941432476043701,"confidence_rate":0.9998750297151664},{"cnt":[[1079,739],[1739,739],[1739,785],[1079,785]],"region":{"top_left_x":1078,"top_left_y":738,"width":662,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ffa7e5f9a444507a5dc8d51ad21fd77","type":"text","conversion_output":false,"parent_id":"bbc9e5608f804fb99e2040b38007bf13","text":"minutes and rest then check BP again.","text_display":" minutes and rest then check BP again.","confidence":1,"confidence_rate":1},{"cnt":[[1076,783],[1494,783],[1494,826],[1076,826]],"region":{"top_left_x":1076,"top_left_y":782,"width":418,"height":45},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31bb7c0e70ba46798fe85c582fcb4499","type":"text","conversion_output":false,"parent_id":"bbc9e5608f804fb99e2040b38007bf13","text":"This may be done twice.","text_display":" This may be done twice.","confidence":1,"confidence_rate":1},{"cnt":[[1016,826],[1706,826],[1706,873],[1016,873]],"region":{"top_left_x":1016,"top_left_y":826,"width":691,"height":47},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e18257d067c447beb367857b7118295f","type":"text","conversion_output":false,"parent_id":"bbc9e5608f804fb99e2040b38007bf13","text":"2. If three BP readings are greater than","text_display":"\n2. If three BP readings are greater than","confidence":1,"confidence_rate":1},{"cnt":[[1082,870],[1679,870],[1679,911],[1082,911]],"region":{"top_left_x":1081,"top_left_y":869,"width":599,"height":42},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3083fc263c04400e9026c45819a89792","type":"text","conversion_output":false,"parent_id":"bbc9e5608f804fb99e2040b38007bf13","text":"170/100, then individual should not","text_display":" 170/100, then individual should not","confidence":1,"confidence_rate":1},{"cnt":[[1076,916],[1237,916],[1237,954],[1076,954]],"region":{"top_left_x":1076,"top_left_y":916,"width":162,"height":39},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fff9e5f991d45d4ab3c039540c7b15f","type":"text","conversion_output":false,"parent_id":"bbc9e5608f804fb99e2040b38007bf13","text":"exercise.","text_display":" exercise.","confidence":1,"confidence_rate":1},{"cnt":[[1016,957],[1734,957],[1734,1001],[1016,1001]],"region":{"top_left_x":1016,"top_left_y":957,"width":718,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd1b153d84af40a0a8054fcc10822086","type":"text","conversion_output":false,"parent_id":"bbc9e5608f804fb99e2040b38007bf13","text":"3. The PCP, clinical site coordinator, and","text_display":"\n3. 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Cancel treatment and call PCP. \\\\\n2. Report to clinical site coordinator and study clinician to follow-up until cleared.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nCall 911. \\\\\n1. Cancel treatment and call PCP. \\\\\n2. 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Stop exercise and have person sit or lie down. \\\\\n2. If sitting is not sufficient to resolve dizziness, then check vital signs. \\\\\n3. Call 911 if clinically unstable. \\\\\n4. Report to PCP if heart rate is less than 60 (and not usually so), the dizziness is new in onset; or if the BP is > 160/100 or systolic <90. \\\\\n5. Report event to clinical site coordinator and study clinician.\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nResting pulse \\\\\nRate > 120 or < 40 beats/min\n\\end{tabular} & \\begin{tabular}{l}\n1. PT will stop delivery of the intervention. \\\\\n2. Qualified staff will consult with the study clinician and follow up as needed. \\\\\n3. PT will resume delivery of the intervention only after the participant receives medical clearance.\n\\end{tabular} \\\\\n\\hline New irregular heart rate with complaint of heart palpitations & \\begin{tabular}{l}\n1. Do not exercise and call PCP. \\\\\n2. Report to clinical site coordinator and study clinician for follow-up. \\\\\n3. Wait for medical clearance to resume exercise.\n\\end{tabular} \\\\\n\\hline New acute musculoskeletal pain during exercise (pain > 5 on VAS) & \\begin{tabular}{l}\n1. Have the participant stop the exercise and rest. \\\\\n2. Attempt to alter position of participant to reduce pain. If pain persists, do not continue specific exercise. Attempt to do other exercises. \\\\\n3. If pain does not resolve, refer to PCP or orthopedist and study clinician.\n\\end{tabular} \\\\\n\\hline New, acute, non-musculoskeletal pain (pain > 5 on VAS) & \\begin{tabular}{l}\n1. Do not exercise. \\\\\n2. Take pain history and call PCP. \\\\\n3. Report to clinical site coordinator and study clinician for follow-up and clearance.\n\\end{tabular} \\\\\n\\hline Acute change in mental status & \\begin{tabular}{l}\n1. Do not exercise. \\\\\n2. Call PCP or if unavailable, call 911. \\\\\n3. Report to clinical site coordinator and study clinician for follow-up and clearance.\n\\end{tabular} \\\\\n\\hline Participant expresses desire to commit suicide & \\begin{tabular}{l}\n1. Call PCP and report findings. \\\\\n2. Report to clinical site coordinator and study clinician for follow-up and clearance.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline ALERT & ACTION \\\\\n\\hline Dizziness during exercise & \\begin{tabular}{l}\n1. Stop exercise and have person sit or lie down. \\\\\n2. If sitting is not sufficient to resolve dizziness, then check vital signs. \\\\\n3. Call 911 if clinically unstable. \\\\\n4. Report to PCP if heart rate is less than 60 (and not usually so), the dizziness is new in onset; or if the BP is > 160/100 or systolic <90. \\\\\n5. Report event to clinical site coordinator and study clinician.\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nResting pulse \\\\\nRate > 120 or < 40 beats/min\n\\end{tabular} & \\begin{tabular}{l}\n1. PT will stop delivery of the intervention. \\\\\n2. Qualified staff will consult with the study clinician and follow up as needed. \\\\\n3. PT will resume delivery of the intervention only after the participant receives medical clearance.\n\\end{tabular} \\\\\n\\hline New irregular heart rate with complaint of heart palpitations & \\begin{tabular}{l}\n1. Do not exercise and call PCP. \\\\\n2. Report to clinical site coordinator and study clinician for follow-up. \\\\\n3. Wait for medical clearance to resume exercise.\n\\end{tabular} \\\\\n\\hline New acute musculoskeletal pain during exercise (pain > 5 on VAS) & \\begin{tabular}{l}\n1. Have the participant stop the exercise and rest. \\\\\n2. Attempt to alter position of participant to reduce pain. If pain persists, do not continue specific exercise. Attempt to do other exercises. \\\\\n3. If pain does not resolve, refer to PCP or orthopedist and study clinician.\n\\end{tabular} \\\\\n\\hline New, acute, non-musculoskeletal pain (pain > 5 on VAS) & \\begin{tabular}{l}\n1. Do not exercise. \\\\\n2. Take pain history and call PCP. \\\\\n3. Report to clinical site coordinator and study clinician for follow-up and clearance.\n\\end{tabular} \\\\\n\\hline Acute change in mental status & \\begin{tabular}{l}\n1. Do not exercise. \\\\\n2. Call PCP or if unavailable, call 911. \\\\\n3. Report to clinical site coordinator and study clinician for follow-up and clearance.\n\\end{tabular} \\\\\n\\hline Participant expresses desire to commit suicide & \\begin{tabular}{l}\n1. Call PCP and report findings. \\\\\n2. Report to clinical site coordinator and study clinician for follow-up and clearance.\n\\end{tabular} 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during exercise","text_display":"Dizziness during exercise","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1011,297],[1784,297],[1784,785],[1011,785]],"region":{"top_left_x":1011,"top_left_y":296,"width":773,"height":489},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ab489f05f184afcab9e67551e30ff15","type":"complex_cell","conversion_output":false,"parent_id":"c3da40a7166e428ca7596d4a1719a1b4","children_ids":["7c95213dbd164c098cdab3846dda23a2","274cd54f08064e36a1599952f9e537f7","8c9bae3b76f24c28a79e548cb8fb297b","2a4f31408de241dcb1b776c3a6d8ff4e","d183e9ef821b45fea188eb6a27e663d0","6d2392dc8f144a3eb464ba4fb93ca5b5","b4a8d32abf794efc917a8b1394a56a0a","8a086508e6124e3c9bc930529cd9e490","cdc2b5f3537b468494fa87c3dac75beb","d4bc1dfff1a546c3af0e56537fc6dcc2","1302b8ffe8ca44a1adfa49851e33bf48"],"text":"\\begin{tabular}{l}\n1. Stop exercise and have person sit or lie down. \\\\\n2. If sitting is not sufficient to resolve dizziness, then check vital signs. \\\\\n3. Call 911 if clinically unstable. \\\\\n4. Report to PCP if heart rate is less than 60 (and not usually so), the dizziness is new in onset; or if the BP is > 160/100 or systolic <90. \\\\\n5. Report event to clinical site coordinator and study clinician.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n1. Stop exercise and have person sit or lie down. \\\\\n2. If sitting is not sufficient to resolve dizziness, then check vital signs. \\\\\n3. Call 911 if clinically unstable. \\\\\n4. Report to PCP if heart rate is less than 60 (and not usually so), the dizziness is new in onset; or if the BP is > 160/100 or systolic <90. \\\\\n5. Report event to clinical site coordinator and study clinician.\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9814453125,"confidence_rate":0.9999614969827623},{"cnt":[[1017,299],[1756,299],[1756,343],[1017,343]],"region":{"top_left_x":1016,"top_left_y":299,"width":741,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c95213dbd164c098cdab3846dda23a2","type":"text","conversion_output":false,"parent_id":"6ab489f05f184afcab9e67551e30ff15","text":"1. Stop exercise and have person sit or lie","text_display":"1. Stop exercise and have person sit or lie","confidence":1,"confidence_rate":1},{"cnt":[[1080,346],[1189,346],[1189,384],[1080,384]],"region":{"top_left_x":1079,"top_left_y":345,"width":110,"height":39},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"274cd54f08064e36a1599952f9e537f7","type":"text","conversion_output":false,"parent_id":"6ab489f05f184afcab9e67551e30ff15","text":"down.","text_display":" down.","confidence":1,"confidence_rate":1},{"cnt":[[1014,384],[1658,384],[1658,430],[1014,430]],"region":{"top_left_x":1014,"top_left_y":383,"width":645,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c9bae3b76f24c28a79e548cb8fb297b","type":"text","conversion_output":false,"parent_id":"6ab489f05f184afcab9e67551e30ff15","text":"2. If sitting is not sufficient to resolve","text_display":"\n2. If sitting is not sufficient to resolve","confidence":1,"confidence_rate":1},{"cnt":[[1080,433],[1634,433],[1634,474],[1080,474]],"region":{"top_left_x":1079,"top_left_y":432,"width":555,"height":42},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a4f31408de241dcb1b776c3a6d8ff4e","type":"text","conversion_output":false,"parent_id":"6ab489f05f184afcab9e67551e30ff15","text":"dizziness, then check vital signs.","text_display":" dizziness, then check vital signs.","confidence":0.9990234375,"confidence_rate":0.999974948015144},{"cnt":[[1014,474],[1574,474],[1574,520],[1014,520]],"region":{"top_left_x":1014,"top_left_y":473,"width":560,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d183e9ef821b45fea188eb6a27e663d0","type":"text","conversion_output":false,"parent_id":"6ab489f05f184afcab9e67551e30ff15","text":"3. Call 911 if clinically unstable.","text_display":"\n3. Call 911 if clinically unstable.","confidence":1,"confidence_rate":1},{"cnt":[[1014,520],[1737,520],[1737,561],[1014,561]],"region":{"top_left_x":1014,"top_left_y":520,"width":724,"height":42},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d2392dc8f144a3eb464ba4fb93ca5b5","type":"text","conversion_output":false,"parent_id":"6ab489f05f184afcab9e67551e30ff15","text":"4. Report to PCP if heart rate is less than","text_display":"\n4. 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Do not exercise and call PCP. \\\\\n2. Report to clinical site coordinator and study clinician for follow-up. \\\\\n3. Wait for medical clearance to resume exercise.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n1. Do not exercise and call PCP. \\\\\n2. Report to clinical site coordinator and study clinician for follow-up. \\\\\n3. Wait for medical clearance to resume exercise.\n\\end{tabular}","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1017,1050],[1590,1050],[1590,1091],[1017,1091]],"region":{"top_left_x":1016,"top_left_y":1049,"width":574,"height":42},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7b7279b025d431880e9d6d075135a3f","type":"text","conversion_output":false,"parent_id":"10908a6f863f47f8a7e40de43ac46379","text":"1. Do not exercise and call PCP.","text_display":"1. 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Participants will be","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1704,473],[1704,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1460,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4fa59cbdd9bc4fd9b594cc5311dcc875","type":"text","conversion_output":true,"text":"supervised at all times and instructed on technique on all activities during the session.","text_display":" supervised at all times and instructed on technique on all activities during the session.","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1764,516],[1764,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1520,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63bfb012af094655adb9daef42dc479b","type":"text","conversion_output":true,"text":"Participants will be instructed to talk with the PTs about any muscle soreness, discomfort,","text_display":" Participants will be instructed to talk with the PTs about any muscle soreness, discomfort,","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[617,559],[617,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":373,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5437a73adc824a889e04bb1063bf5105","type":"text","conversion_output":true,"text":"tingling or numbness.","text_display":" tingling or numbness.","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1751,645],[1751,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1507,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4da4c46d09946359de9510934075982","type":"text","conversion_output":true,"text":"Every effort will be made to prevent AEs including stopping intervention activity when the","text_display":"\n\nEvery effort will be made to prevent AEs including stopping intervention activity when the","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1828,692],[1828,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1585,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fe79d803bc54ec289c59a6d281bc287","type":"text","conversion_output":true,"text":"participant reports discomfort. Precautions for TENS use include not placing the electrodes in","text_display":" participant reports discomfort. Precautions for TENS use include not placing the electrodes in","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1863,735],[1863,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1619,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee70e8051b0a40b9a9ff280d18c924c1","type":"text","conversion_output":true,"text":"the thoracic region in the presence of demand-inhibited synchronous pacemakers, checking for","text_display":" the thoracic region in the presence of demand-inhibited synchronous pacemakers, checking for","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1818,778],[1818,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1574,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0170b74baff94bb4a5f2c75bd5933d35","type":"text","conversion_output":true,"text":"skin irritation from the electrodes, and keeping the current path outside of open wounds. PTs","text_display":" skin irritation from the electrodes, and keeping the current path outside of open wounds. PTs","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1695,821],[1695,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1452,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7574e7c597554c468e0a81e281e3bcb5","type":"text","conversion_output":true,"text":"will monitor blood pressure at the start of the training session, mid-session, and when","text_display":" will monitor blood pressure at the start of the training session, mid-session, and when","confidence":1,"confidence_rate":1},{"cnt":[[245,866],[1867,866],[1867,913],[245,913]],"region":{"top_left_x":244,"top_left_y":865,"width":1623,"height":49},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c16bf44f427438b8cc6ea21878aa5c2","type":"text","conversion_output":true,"text":"participants are finished with the session. Blood pressure and heart rate will be monitored using","text_display":" participants are finished with the session. Blood pressure and heart rate will be monitored using","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1747,911],[1747,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1503,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb14d3cc98064b0fa930e8454a7c4dad","type":"text","conversion_output":true,"text":"a standard blood pressure cuff and palpation of peripheral pulse. The PT will monitor the","text_display":" a standard blood pressure cuff and palpation of peripheral pulse. The PT will monitor the","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,954],[1751,954],[1751,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1507,"height":49},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7643a3dc338d44ba830218d6e0ada660","type":"text","conversion_output":true,"text":"participant for signs of muscle strain, dizziness, or hypotension and appropriate palliative","text_display":" participant for signs of muscle strain, dizziness, or hypotension and appropriate palliative","confidence":1,"confidence_rate":1},{"cnt":[[245,999],[1850,999],[1850,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":999,"width":1606,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c503789957d6498ba210f5f3723a6369","type":"text","conversion_output":true,"text":"methods will be discussed with the participants and appropriate medical referrals will be made.","text_display":" methods will be discussed with the participants and appropriate medical referrals will be made.","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1880,1042],[1880,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1636,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74f65f361c5945ebbf708c7ed9283f3c","type":"text","conversion_output":true,"text":"The level of sensory stimulation provided during the intervention will be at a level that should not","text_display":" The level of sensory stimulation provided during the intervention will be at a level that should not","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[823,1087],[823,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":579,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"574f3d43da4a4aca856829851b435310","type":"text","conversion_output":true,"text":"cause pain or muscle contraction.","text_display":" cause pain or muscle contraction.","confidence":1,"confidence_rate":1},{"cnt":[[367,1169],[1472,1169],[1472,1222],[367,1222]],"region":{"top_left_x":367,"top_left_y":1168,"width":1105,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3b6e2fe7e7b442ea3c78477c364a4a7","type":"section_header","conversion_output":false,"children_ids":["7f1e5c09d52644a59677da0be8244371"],"text":"","text_display":""},{"cnt":[[374,1173],[1467,1173],[1467,1218],[374,1218]],"region":{"top_left_x":373,"top_left_y":1173,"width":1095,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f1e5c09d52644a59677da0be8244371","type":"text","conversion_output":true,"parent_id":"c3b6e2fe7e7b442ea3c78477c364a4a7","text":"12.1.7 Safety Considerations for the Nutritional Intervention","text_display":"\n\n\\subsection*{12.1.7 Safety Considerations for the Nutritional Intervention}","confidence":0.8574912548065186,"confidence_rate":0.9976732520165121},{"cnt":[[245,1216],[1755,1216],[1755,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1512,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccc1c90d768946998dca3d42be596240","type":"text","conversion_output":true,"text":"Individuals who have sustained a hip fracture are frequently at risk for protein and calorie","text_display":"\n\nIndividuals who have sustained a hip fracture are frequently at risk for protein and calorie","confidence":1,"confidence_rate":1},{"cnt":[[245,1259],[1854,1259],[1854,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1258,"width":1611,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d516b536f59f4bc8bb37646848ffa44d","type":"text","conversion_output":true,"text":"malnutrition and have low calcium and vitamin D intake. \\({ }^{205}\\) Individuals enrolled in the study will","text_display":" malnutrition and have low calcium and vitamin D intake. \\({ }^{205}\\) Individuals enrolled in the study will","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[1867,1302],[1867,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1301,"width":1623,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa8273f12f6e4cfeb3738c2ebb49f1ee","type":"text","conversion_output":true,"text":"be screened with the MNA®-SF and if their scores indicate that they are malnourished, they will","text_display":" be screened with the MNA®-SF and if their scores indicate that they are malnourished, they will","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1349],[1858,1349],[1858,1396],[245,1396]],"region":{"top_left_x":244,"top_left_y":1349,"width":1615,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ed6aca6955d4ee39d845addb3094eee","type":"text","conversion_output":true,"text":"receive in-person nutritional counseling by a registered dietician. Individuals enrolled that have","text_display":" receive in-person nutritional counseling by a registered dietician. Individuals enrolled that have","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[1852,1392],[1852,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1608,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bba505d7b2674595af07612dffcd170a","type":"text","conversion_output":true,"text":"a serum albumin value \\(2.5-3.5\\) will also receive in-person nutritional counseling by a registered","text_display":" a serum albumin value \\(2.5-3.5\\) will also receive in-person nutritional counseling by a registered","confidence":0.8940944671630859,"confidence_rate":0.9989241960018752},{"cnt":[[245,1435],[1803,1435],[1803,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1435,"width":1559,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b3e3b8c66634badbed62c1114cae9e5","type":"text","conversion_output":true,"text":"dietician, regardless of score on the MNA®-SF. Participants who are at risk or not at risk for","text_display":" dietician, regardless of score on the MNA®-SF. Participants who are at risk or not at risk for","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1837,1482],[1837,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1482,"width":1593,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7923cba84e4a466e85b2c4ef30b87d19","type":"text","conversion_output":true,"text":"malnutrition will receive a telephone consultation from the dietician on maintaining proper diet.","text_display":" malnutrition will receive a telephone consultation from the dietician on maintaining proper diet.","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1852,1525],[1852,1573],[245,1573]],"region":{"top_left_x":244,"top_left_y":1525,"width":1608,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e2bec6244a84a63b7a8e2c6f7c6f7c3","type":"text","conversion_output":true,"text":"The RD will schedule an in-person visit for those at risk if he/she feels it is necessary based on","text_display":" The RD will schedule an in-person visit for those at risk if he/she feels it is necessary based on","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1729,1568],[1729,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1486,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7633ca6b2794a2fb0f4344ddb1ad3cf","type":"text","conversion_output":true,"text":"the telephone consultation, All subjects will receive vitamin D, calcium, and multivitamin","text_display":" the telephone consultation, All subjects will receive vitamin D, calcium, and multivitamin","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1611],[1781,1611],[1781,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1538,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6755424ccb304f5e8dab00064ace713c","type":"text","conversion_output":true,"text":"supplementation for the 16-week study period, all of which represent best practices for this","text_display":" supplementation for the 16-week study period, all of which represent best practices for this","confidence":0.61865234375,"confidence_rate":0.9950615970332559},{"cnt":[[245,1659],[1818,1659],[1818,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1574,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"338770a0946f4e7b8cc3bb167a6e882a","type":"text","conversion_output":true,"text":"disabled group of participants. There are small risks associated with vitamin D, calcium, and","text_display":" disabled group of participants. There are small risks associated with vitamin D, calcium, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[1772,1702],[1772,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":1529,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24e53f844bc344d1b9dcfb4aef464d13","type":"text","conversion_output":true,"text":"multivitamins including gastrointestinal complaints (including mild constipation or diarrhea,","text_display":" multivitamins including gastrointestinal complaints (including mild constipation or diarrhea,","confidence":1,"confidence_rate":1},{"cnt":[[245,1745],[1826,1745],[1826,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1744,"width":1583,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7c1f701d5e947889cf8ac7d9e69c19c","type":"text","conversion_output":true,"text":"stomach upset) and kidney stones. Those with a calculated creatinine clearance \\(<30 ml / min\\),","text_display":" stomach upset) and kidney stones. Those with a calculated creatinine clearance \\(<30 ml / min\\),","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1826,1788],[1826,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1583,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2002648394df4469b0c09cf129f5e3b9","type":"text","conversion_output":true,"text":"elevated total or ionized calcium, or history of kidney stones, primary hyperparathyroidism, or","text_display":" elevated total or ionized calcium, or history of kidney stones, primary hyperparathyroidism, or","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[1848,1830],[1848,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1830,"width":1604,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfa0411414c74cccb4f444343b4d8ace","type":"text","conversion_output":true,"text":"sarcoidosis will not receive calcium supplements. A participant who experiences an episode of","text_display":" sarcoidosis will not receive calcium supplements. 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In the event that a weight","text_display":" referred to the registered dietician for follow-up by telephone. 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there is weight loss of \\(5 \\%\\)","text_display":"up assessment will be compared to his or her baseline weight and, if there is weight loss of \\(5 \\%\\)","confidence":0.99853515625,"confidence_rate":0.9999851928603086},{"cnt":[[245,2183],[1850,2183],[1850,2232],[245,2232]],"region":{"top_left_x":244,"top_left_y":2182,"width":1606,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21067620c9f94fa69237eaa2f07a3fbe","type":"text","conversion_output":true,"text":"or more, the clinical site PI or clinical site clinician will review the participant's weight trajectory,","text_display":" or more, the clinical site PI or clinical site clinician will review the participant's weight 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this study, any event that meets the criteria for an SAE, is unexpected, or","text_display":"\n\nFor the purposes of this study, any event that meets the criteria for an SAE, is unexpected, or","confidence":1,"confidence_rate":1},{"cnt":[[245,524],[1846,524],[1846,569],[245,569]],"region":{"top_left_x":244,"top_left_y":524,"width":1602,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a652dc80418b4e2b88bfbc1526f4d143","type":"text","conversion_output":true,"text":"results in injury to the participant while s/he is under the supervision of study related personnel","text_display":" results in injury to the participant while s/he is under the supervision of study related 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Severity}","confidence":1,"confidence_rate":1},{"cnt":[[245,829],[1379,829],[1379,879],[245,879]],"region":{"top_left_x":244,"top_left_y":829,"width":1136,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"169340be3070494da3ae64b27eee714e","type":"text","conversion_output":true,"text":"The following guidelines will be used to determine level of severity:","text_display":"\n\nThe following guidelines will be used to determine level of severity:","confidence":1,"confidence_rate":1},{"cnt":[[245,917],[1807,917],[1807,965],[245,965]],"region":{"top_left_x":244,"top_left_y":917,"width":1563,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73bbe942196a432a888c9290ea22359b","type":"text","conversion_output":true,"text":"Mild: Awareness of signs or symptoms, but easily tolerated and causing no loss of time from","text_display":"\nMild: Awareness of signs or symptoms, but easily tolerated and causing no loss of time from","confidence":1,"confidence_rate":1},{"cnt":[[245,962],[1285,962],[1285,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":962,"width":1041,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e223206104644b5cb10a940e190331d4","type":"text","conversion_output":true,"text":"normal activities. 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Expected AEs are captured in a standardized way by blinded personnel.","text_display":" 13.3). 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significant disability (e.g., hip","confidence":1,"confidence_rate":1},{"cnt":[[430,382],[587,382],[587,432],[430,432]],"region":{"top_left_x":429,"top_left_y":382,"width":158,"height":50},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50851ddbf5d34b6db6e598f634a57e55","type":"text","conversion_output":true,"text":"fracture)","text_display":" fracture)","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1798,471],[1798,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1555,"height":48},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f86c137e93204c8f9b213be6efe03f25","type":"text","conversion_output":true,"text":"SAEs will be captured through telephone interviews every four weeks by blinded personnel,","text_display":"\n\nSAEs will be captured through telephone interviews every four weeks by blinded personnel,","confidence":0.99951171875,"confidence_rate":0.9999948042635181},{"cnt":[[245,516],[1811,516],[1811,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1568,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fcb08b4673c49df8e035ffb8028335d","type":"text","conversion_output":true,"text":"using the Reportable Adverse Events Form. SAEs will also be assessed at the beginning of","text_display":" using the Reportable Adverse Events Form. SAEs will also be assessed at the beginning of","confidence":0.9990234375,"confidence_rate":0.9999894942525209},{"cnt":[[245,559],[1781,559],[1781,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1538,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b425e8c530f3471c8751cd70726abfb8","type":"text","conversion_output":true,"text":"each PT visit and clinical site follow-up visit, and by any study staff who learns of a serious","text_display":" each PT visit and clinical site follow-up visit, and by any study staff who learns of a serious","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[359,602],[359,645],[245,645]],"region":{"top_left_x":244,"top_left_y":601,"width":115,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e8a7db6a16e4502aa92acee2ce13c26","type":"text","conversion_output":true,"text":"event.","text_display":" event.","confidence":1,"confidence_rate":1},{"cnt":[[365,683],[1008,683],[1008,741],[365,741]],"region":{"top_left_x":365,"top_left_y":683,"width":643,"height":59},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abfa74227ae24088803ed3ccb4d32617","type":"section_header","conversion_output":false,"children_ids":["469dc366ba934f16b2d8851d9c50c061"],"text":"","text_display":""},{"cnt":[[372,688],[999,688],[999,737],[372,737]],"region":{"top_left_x":371,"top_left_y":687,"width":629,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"469dc366ba934f16b2d8851d9c50c061","type":"text","conversion_output":true,"parent_id":"abfa74227ae24088803ed3ccb4d32617","text":"13.4.2 Unexpected Adverse Event","text_display":"\n\n\\subsection*{13.4.2 Unexpected Adverse Event}","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1850,735],[1850,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1606,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de67a6e1abbf494a83fcdc10c88e876a","type":"text","conversion_output":true,"text":"Unexpected AEs will be defined as medical events that occur during study participation, but do","text_display":"\n\nUnexpected AEs will be defined as medical events that occur during study participation, but do","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1815,778],[1815,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1572,"height":51},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f57fa7dea0d49f9b2acc95eb8d9b8e6","type":"text","conversion_output":true,"text":"not commonly occur in the CAP study population and which are not listed in the ICF or study","text_display":" not commonly occur in the CAP study population and which are not listed in the ICF or study","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1798,821],[1798,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1555,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4888add2ce07460b8742fed8855dc4a0","type":"text","conversion_output":true,"text":"protocol (section 13.3). An unexpected AE may be witnessed by a member of the research","text_display":" protocol (section 13.3). An unexpected AE may be witnessed by a member of the research","confidence":0.9736814266070724,"confidence_rate":0.999706953866776},{"cnt":[[245,868],[1824,868],[1824,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1581,"height":47},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9aa84fb2a7c140b3aea511b8ba07e83f","type":"text","conversion_output":true,"text":"team, or staff may be told about an unexpected event that may meet the criteria for reporting.","text_display":" team, or staff may be told about an unexpected event that may meet the criteria for reporting.","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1796,911],[1796,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1553,"height":47},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b460d5453d9745bf8173545291749c66","type":"text","conversion_output":true,"text":"Unexpected AEs that have a potential relationship to study procedures and activities will be","text_display":" Unexpected AEs that have a potential relationship to study procedures and activities will be","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,954],[1850,954],[1850,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1606,"height":49},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85ad229752c94622aa5467b17c9c2a55","type":"text","conversion_output":true,"text":"captured on an Incident Report and submitted to the clinical site study office where they will be","text_display":" captured on an Incident Report and submitted to the clinical site study office where they will be","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1772,997],[1772,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":996,"width":1529,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3bdb71ce848b4beb8b3652f249fa361d","type":"text","conversion_output":true,"text":"logged in the participant binder and then reported to the CCC and the Independent Safety","text_display":" logged in the participant binder and then reported to the CCC and the Independent Safety","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[496,1042],[496,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":253,"height":49},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e9fd1f929e54881bdd6c4a136726cd7","type":"text","conversion_output":true,"text":"Monitor (ISM).","text_display":" Monitor (ISM).","confidence":1,"confidence_rate":1},{"cnt":[[243,1128],[1562,1128],[1562,1175],[243,1175]],"region":{"top_left_x":242,"top_left_y":1127,"width":1320,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aab28233f472427e80c0fc863606e982","type":"text","conversion_output":true,"text":"A reportable unexpected \\(A E\\) will be one that meets all of the following criteria:","text_display":"\n\nA reportable unexpected \\(A E\\) will be one that meets all of the following criteria:","confidence":0.6210386753082275,"confidence_rate":0.9946014213502316},{"cnt":[[369,1175],[1745,1173],[1745,1222],[370,1225]],"region":{"top_left_x":369,"top_left_y":1172,"width":1376,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8db029d05d3d46b6b9ff1dcd1c0f3352","type":"text","conversion_output":true,"text":"- Unexpected, in terms of nature, severity, or frequency, given (a) the research","text_display":"\n- Unexpected, in terms of nature, severity, or frequency, given (a) the research","confidence":1,"confidence_rate":1},{"cnt":[[432,1216],[1833,1216],[1833,1265],[432,1265]],"region":{"top_left_x":431,"top_left_y":1216,"width":1402,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfc4d38c5a30465d88a6e5490f4cbd68","type":"text","conversion_output":true,"text":"procedures that are described in the protocol-related documents, such as the IRB-","text_display":" procedures that are described in the protocol-related documents, such as the IRB","confidence":1,"confidence_rate":1},{"cnt":[[432,1263],[1725,1263],[1725,1308],[432,1308]],"region":{"top_left_x":431,"top_left_y":1263,"width":1295,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f99bbec9d494604a5839636d765e703","type":"text","conversion_output":true,"text":"approved research protocol and ICF; and (b) the characteristics of the study","text_display":"approved research protocol and ICF; and (b) the characteristics of the study","confidence":0.99609375,"confidence_rate":0.9999516814226747},{"cnt":[[430,1306],[629,1306],[629,1351],[430,1351]],"region":{"top_left_x":429,"top_left_y":1306,"width":201,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c53e04652e9d47a886408195d715c34d","type":"text","conversion_output":true,"text":"population;","text_display":" population;","confidence":1,"confidence_rate":1},{"cnt":[[370,1349],[1830,1349],[1830,1396],[370,1396]],"region":{"top_left_x":369,"top_left_y":1349,"width":1462,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c46fedc9ac294fbb9b78007291efab67","type":"text","conversion_output":true,"text":"- Related or possibly related to participation in the research (meaning that there is a","text_display":"\n- Related or possibly related to participation in the research (meaning that there is a","confidence":1,"confidence_rate":1},{"cnt":[[432,1392],[1781,1392],[1781,1439],[432,1439]],"region":{"top_left_x":431,"top_left_y":1392,"width":1351,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdc24f5c827b4854a7a8c50418d10a8b","type":"text","conversion_output":true,"text":"reasonable possibility that the incident, experience, or outcome may have been","text_display":" reasonable possibility that the incident, experience, or outcome may have been","confidence":1,"confidence_rate":1},{"cnt":[[432,1437],[1319,1437],[1319,1485],[432,1485]],"region":{"top_left_x":431,"top_left_y":1437,"width":889,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5dc9485151ec48c981ed5a6c672498d4","type":"text","conversion_output":true,"text":"caused by the procedures involved in the research);","text_display":" caused by the procedures involved in the research);","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[370,1482],[1807,1482],[1807,1528],[370,1528]],"region":{"top_left_x":369,"top_left_y":1482,"width":1438,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dedde117ed8d41eaa2ff8aeb2187cc62","type":"text","conversion_output":true,"text":"- Suggests that the research places participants or others at a greater risk of harm","text_display":"\n- Suggests that the research places participants or others at a greater risk of harm","confidence":1,"confidence_rate":1},{"cnt":[[434,1525],[1811,1525],[1811,1573],[434,1573]],"region":{"top_left_x":433,"top_left_y":1525,"width":1379,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"499ac4d91f2c4d099b8e2da5b494fb7e","type":"text","conversion_output":true,"text":"(including physical, psychological, economic, or social harm) than was previously","text_display":" (including physical, psychological, economic, or social harm) than was previously","confidence":1,"confidence_rate":1},{"cnt":[[432,1568],[804,1568],[804,1618],[432,1618]],"region":{"top_left_x":431,"top_left_y":1568,"width":373,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc0fee18254a41f5b1e6395a58b9e9d3","type":"text","conversion_output":true,"text":"known or recognized.","text_display":" known or recognized.","confidence":1,"confidence_rate":1},{"cnt":[[245,1656],[1807,1656],[1807,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1656,"width":1563,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"234683f450a04935a4f398a1609d94a6","type":"text","conversion_output":true,"text":"The medical and scientific judgment of the clinical site clinician and the clinical site PI will be","text_display":"\n\nThe medical and scientific judgment of the clinical site clinician and the clinical site PI will be","confidence":0.99755859375,"confidence_rate":0.9999764965133096},{"cnt":[[245,1702],[1697,1702],[1697,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":1454,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a70b6b1248284c9096bc6ff20c4e41f8","type":"text","conversion_output":true,"text":"exercised in deciding whether an occurrence should be reported. In addition, difficulty","text_display":" exercised in deciding whether an occurrence should be reported. In addition, difficulty","confidence":1,"confidence_rate":1},{"cnt":[[245,1745],[1863,1745],[1863,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1744,"width":1619,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"153161bbcbaf46c2b48ebb8d2cd4fbd6","type":"text","conversion_output":true,"text":"determining whether or not an event is unexpected and/or attributable to the intervention will be","text_display":" determining whether or not an event is unexpected and/or attributable to the intervention will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1457,1788],[1457,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1213,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6d9459fc0eb4c4c8272bf24eb14a41b","type":"text","conversion_output":true,"text":"addressed by the ISM, who will determine if the event is to be reported.","text_display":" addressed by the ISM, who will determine if the event is to be reported.","confidence":1,"confidence_rate":1},{"cnt":[[370,1878],[1865,1878],[1865,1927],[370,1927]],"region":{"top_left_x":369,"top_left_y":1877,"width":1496,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"163036be1a9b4a569fd36509eb9a9c20","type":"text","conversion_output":true,"text":"13.4.3 Injury that Occurs while Under the Supervision of Study Related Personnel","text_display":"\n13.4.3 Injury that Occurs while Under the Supervision of Study Related Personnel","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1871,1925],[1871,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1628,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c28a37101d0f45b49900affdf556d046","type":"text","conversion_output":true,"text":"Any injury that occurs while the participant is under the supervision of study-related personnel is","text_display":" Any injury that occurs while the participant is under the supervision of study-related personnel is","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1850,1968],[1850,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1967,"width":1606,"height":47},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9138b1082e54472889915cde37e8e7c6","type":"text","conversion_output":true,"text":"reportable. The injury can happen on site (during an assessment visit or during the conduct of","text_display":" reportable. The injury can happen on site (during an assessment visit or during the conduct of","confidence":1,"confidence_rate":1},{"cnt":[[245,2013],[1828,2013],[1828,2058],[245,2058]],"region":{"top_left_x":244,"top_left_y":2013,"width":1585,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb5f26f46fea45caa5bb9312b9bf0582","type":"text","conversion_output":true,"text":"an ancillary study to CAP) or off-site (in the participant's home during a PT visit or if the study","text_display":" an ancillary study to CAP) or off-site (in the participant's home during a PT visit or if the study","confidence":1,"confidence_rate":1},{"cnt":[[245,2056],[1781,2056],[1781,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2056,"width":1538,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9e64765d8b544338daea88db466e6e8","type":"text","conversion_output":true,"text":"offers supervision during transportation). These events will be captured on the Reportable","text_display":" offers supervision during transportation). 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RAEs will be reported to the clinical site PI and clinical site clinician as soon as the event","text_display":"\n1. RAEs will be reported to the clinical site PI and clinical site clinician as soon as the event","confidence":0.4604778289794922,"confidence_rate":0.9924259798230707},{"cnt":[[372,387],[535,387],[535,423],[372,423]],"region":{"top_left_x":371,"top_left_y":386,"width":164,"height":38},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41fa544fd1414e1d9f9d1fe403203460","type":"text","conversion_output":true,"text":"is known.","text_display":" is known.","confidence":1,"confidence_rate":1},{"cnt":[[309,425],[1863,425],[1863,473],[309,473]],"region":{"top_left_x":309,"top_left_y":425,"width":1554,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f26dda85b01540ceadf844ec10586460","type":"text","conversion_output":true,"text":"2. The clinical site PI (or designee) will redact documents to conceal treatment assignment","text_display":"\n2. 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To ensure the appropriate classification of events, the","text_display":" protocol and ICF should be considered. 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The ISM will be responsible for:","text_display":"call ISM to make a determination. The ISM will be responsible for:","confidence":1,"confidence_rate":1},{"cnt":[[372,1315],[904,1315],[904,1360],[372,1360]],"region":{"top_left_x":371,"top_left_y":1314,"width":534,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27a1ad3bb0c94191943c345917af57f6","type":"text","conversion_output":true,"text":"- Reviewing reports of RAEs;","text_display":"\n- Reviewing reports of RAEs;","confidence":1,"confidence_rate":1},{"cnt":[[372,1358],[1448,1358],[1448,1403],[372,1403]],"region":{"top_left_x":371,"top_left_y":1357,"width":1078,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3c53d638b26453a861b290845353288","type":"text","conversion_output":true,"text":"- Confirming or refuting classification of the event as an RAE;","text_display":"\n- Confirming or refuting classification of the event as an RAE;","confidence":1,"confidence_rate":1},{"cnt":[[372,1401],[1356,1401],[1356,1446],[372,1446]],"region":{"top_left_x":371,"top_left_y":1400,"width":985,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d55cd5e7fc904075b7c91fe0a4283f06","type":"text","conversion_output":true,"text":"- Making a determination about relatedness of the RAE;","text_display":"\n- Making a determination about relatedness of the RAE;","confidence":1,"confidence_rate":1},{"cnt":[[372,1446],[1766,1446],[1766,1491],[372,1491]],"region":{"top_left_x":371,"top_left_y":1445,"width":1396,"height":47},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42bcbccb0f1f475ca9c7ac59cdeda314","type":"text","conversion_output":true,"text":"- Requesting additional information as needed in order to make a determination;","text_display":"\n- Requesting additional information as needed in order to make a determination;","confidence":1,"confidence_rate":1},{"cnt":[[372,1491],[1768,1491],[1768,1536],[372,1536]],"region":{"top_left_x":371,"top_left_y":1491,"width":1398,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82c46cde54954c488ba8065ab49cec10","type":"text","conversion_output":true,"text":"- Providing the CCC with follow-up reports for ongoing RAEs as new information","text_display":"\n- Providing the CCC with follow-up reports for ongoing RAEs as new information","confidence":1,"confidence_rate":1},{"cnt":[[434,1534],[840,1534],[840,1575],[434,1575]],"region":{"top_left_x":433,"top_left_y":1533,"width":408,"height":42},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9008fe421e6046f3a6a48c6d7ab7dcf0","type":"text","conversion_output":true,"text":"becomes available; and","text_display":" becomes available; and","confidence":1,"confidence_rate":1},{"cnt":[[372,1577],[1768,1577],[1768,1622],[372,1622]],"region":{"top_left_x":371,"top_left_y":1576,"width":1398,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60eaf3657d4f403a8d163b92987ac1b6","type":"text","conversion_output":true,"text":"- Notifying the CCC of the final status for the event once it has been determined.","text_display":"\n- Notifying the CCC of the final status for the event once it has been determined.","confidence":1,"confidence_rate":1},{"cnt":[[275,1667],[1334,1667],[1334,1721],[275,1721]],"region":{"top_left_x":275,"top_left_y":1667,"width":1060,"height":54},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"639b19ef7f1c4460826b0e2819c59696","type":"section_header","conversion_output":false,"children_ids":["bd808d25690d412b9f19830ac1a6c0c3"],"text":"","text_display":""},{"cnt":[[279,1671],[1330,1671],[1330,1717],[279,1717]],"region":{"top_left_x":279,"top_left_y":1671,"width":1051,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd808d25690d412b9f19830ac1a6c0c3","type":"text","conversion_output":true,"parent_id":"639b19ef7f1c4460826b0e2819c59696","text":"13.8 Reporting Expected AEs and RAEs to the DSMB","text_display":"\n\n\\subsection*{13.8 Reporting Expected AEs and RAEs to the DSMB}","confidence":1,"confidence_rate":1},{"cnt":[[245,1719],[1865,1719],[1865,1764],[245,1764]],"region":{"top_left_x":244,"top_left_y":1718,"width":1621,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b34f38aeae6a4551b797cd66f72e6ad4","type":"text","conversion_output":true,"text":"The DSMB will review tabulated data on non-serious and expected AEs on a semi-annual basis","text_display":"\n\nThe DSMB will review tabulated data on non-serious and expected AEs on a semi-annual basis","confidence":1,"confidence_rate":1},{"cnt":[[245,1762],[1837,1762],[1837,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1761,"width":1593,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c742adc865af40f28451e42e10685e82","type":"text","conversion_output":true,"text":"and monitor for adverse event rates out of proportion to those expected. The CCC will forward","text_display":" and monitor for adverse event rates out of proportion to those expected. The CCC will forward","confidence":1,"confidence_rate":1},{"cnt":[[245,1805],[1837,1805],[1837,1850],[245,1850]],"region":{"top_left_x":244,"top_left_y":1804,"width":1593,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0af0b3c9b714f8db0e6454e8a55e449","type":"text","conversion_output":true,"text":"the individual Reportable Adverse Event Records, including a narrative for each event, as well","text_display":" the individual Reportable Adverse Event Records, including a narrative for each event, as well","confidence":1,"confidence_rate":1},{"cnt":[[245,1848],[1790,1848],[1790,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1847,"width":1546,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea5635ae2b9c4fa1b5790c6821e651ea","type":"text","conversion_output":true,"text":"as a table showing all RAEs to the DSMB and NIA semi-annually. The DSMB will review all","text_display":" as a table showing all RAEs to the DSMB and NIA semi-annually. The DSMB will review all","confidence":1,"confidence_rate":1},{"cnt":[[247,1893],[1723,1893],[1723,1940],[247,1940]],"region":{"top_left_x":247,"top_left_y":1892,"width":1477,"height":49},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dafefaa4651d45a5b300772b4d4cece2","type":"text","conversion_output":true,"text":"RAEs that are temporally related to the interventions in aggregate form at its scheduled","text_display":" RAEs that are temporally related to the interventions in aggregate form at its scheduled","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[415,1938],[415,1983],[245,1983]],"region":{"top_left_x":244,"top_left_y":1937,"width":171,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"871c533eda5a4b5c8d5c3ebeb032b045","type":"text","conversion_output":true,"text":"meetings.","text_display":" meetings.","confidence":1,"confidence_rate":1},{"cnt":[[245,2024],[1867,2024],[1867,2069],[245,2069]],"region":{"top_left_x":244,"top_left_y":2023,"width":1623,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfdfb3272992404ca0b484456135850a","type":"text","conversion_output":true,"text":"All RAEs that relate to hazards of the study interventions or are cause for urgent concern will be","text_display":"\n\nAll RAEs that relate to hazards of the study interventions or are cause for urgent concern will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2067],[1826,2067],[1826,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2066,"width":1583,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1b891bff9724d4c95d093369c31da71","type":"text","conversion_output":true,"text":"reported to the CCC and the CCC will report these to the DSMB chairman, NIA, and the UMB","text_display":" reported to the CCC and the CCC will report these to the DSMB chairman, NIA, and the UMB","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[247,2114],[1846,2114],[1846,2159],[247,2159]],"region":{"top_left_x":247,"top_left_y":2114,"width":1599,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e473da4c7d134e36902ee31b413bc3fd","type":"text","conversion_output":true,"text":"IRB immediately after recognition of their importance. If the DSMB chairman concludes that an","text_display":" IRB immediately after recognition of their importance. If the DSMB chairman concludes that an","confidence":1,"confidence_rate":1},{"cnt":[[247,2157],[1841,2157],[1841,2202],[247,2202]],"region":{"top_left_x":247,"top_left_y":2157,"width":1595,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31d8e7804de747b09fcfb4a434ac3012","type":"text","conversion_output":true,"text":"RAE is of universal and immediate concern, the CCC will notify local clinical sites at once. The","text_display":" RAE is of universal and immediate concern, the CCC will notify local clinical sites at once. The","confidence":1,"confidence_rate":1},{"cnt":[[247,2200],[1824,2200],[1824,2245],[247,2245]],"region":{"top_left_x":247,"top_left_y":2200,"width":1578,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ae1c7460cfd4b93aaa077f47cc08ec2","type":"text","conversion_output":true,"text":"DSMB chairman may recommend convening the DSMB to review participant safety based on","text_display":" DSMB chairman may recommend convening the DSMB to review participant safety based on","confidence":1,"confidence_rate":1},{"cnt":[[245,2243],[1766,2243],[1766,2290],[245,2290]],"region":{"top_left_x":244,"top_left_y":2242,"width":1523,"height":49},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90ae4530c5b941dbaa38f87700e51d69","type":"text","conversion_output":true,"text":"any individual report or accumulating evidence, including evidence according to treatment","text_display":" any individual report or accumulating evidence, including evidence according to treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,2290],[475,2290],[475,2335],[245,2335]],"region":{"top_left_x":244,"top_left_y":2290,"width":231,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a837c97e927e4168a4f67c93c4119aae","type":"text","conversion_output":true,"text":"assignments.","text_display":" assignments.","confidence":1,"confidence_rate":1},{"cnt":[[247,2587],[660,2587],[660,2623],[247,2623]],"region":{"top_left_x":247,"top_left_y":2586,"width":413,"height":38},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"201d928bf693438fa733ebd8e99884c9","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22b1d89bfb0b442c88a90d3784b4e260","type":"page_info","conversion_output":false,"text":"58","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-078","page":78,"lines":[{"cnt":[[245,249],[1197,249],[1197,305],[245,305]],"region":{"top_left_x":244,"top_left_y":249,"width":953,"height":57},"line":1,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"7a664ea92c424c32bd8f389befd4da1b","type":"section_header","conversion_output":false,"children_ids":["f33e3cd403d649cfb8d8e2f63c50fe54"],"text":"","text_display":""},{"cnt":[[249,254],[1192,254],[1192,301],[249,301]],"region":{"top_left_x":249,"top_left_y":253,"width":944,"height":48},"line":2,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"f33e3cd403d649cfb8d8e2f63c50fe54","type":"text","conversion_output":true,"parent_id":"7a664ea92c424c32bd8f389befd4da1b","text":"Section 14: Intervention Discontinuation","text_display":"\n\n\\section*{Section 14: Intervention Discontinuation}","confidence":1,"confidence_rate":1},{"cnt":[[247,331],[1708,331],[1708,372],[247,372]],"region":{"top_left_x":247,"top_left_y":330,"width":1462,"height":42},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a81ab580e7b948ed9cc36669af7dfb83","type":"text","conversion_output":true,"text":"Certain RAEs may result in a temporary interruption or early discontinuation of the trial","text_display":"\n\nCertain RAEs may result in a temporary interruption or early discontinuation of the trial","confidence":0.9960973262786865,"confidence_rate":0.9999584018330546},{"cnt":[[247,374],[1858,374],[1858,417],[247,417]],"region":{"top_left_x":247,"top_left_y":373,"width":1612,"height":44},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"741769cb6655405e8a4c7507572ac08f","type":"text","conversion_output":true,"text":"assessments and interventions or components of these assessments and interventions. Please","text_display":" assessments and interventions or components of these assessments and interventions. Please","confidence":1,"confidence_rate":1},{"cnt":[[249,417],[1766,417],[1766,462],[249,462]],"region":{"top_left_x":249,"top_left_y":416,"width":1518,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"595f7f7323e74c728e8970b52c035d3d","type":"text","conversion_output":true,"text":"refer to the appropriate MOP chapter(s) for specific instructions on stopping criteria during","text_display":" refer to the appropriate MOP chapter(s) for specific instructions on stopping criteria during","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[249,460],[1128,460],[1128,505],[249,505]],"region":{"top_left_x":249,"top_left_y":459,"width":879,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"920fb2c588374fb5bc4ba7cab0aecc9c","type":"text","conversion_output":true,"text":"screening, intervention, and follow-up assessments.","text_display":" screening, intervention, and follow-up assessments.","confidence":1,"confidence_rate":1},{"cnt":[[245,550],[1790,550],[1790,591],[245,591]],"region":{"top_left_x":244,"top_left_y":550,"width":1546,"height":41},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d96902470c99452bb2f6b6d7358251ef","type":"text","conversion_output":true,"text":"After such RAEs occur, a participant may resume the trial intervention when the clinical site","text_display":"\n\nAfter such RAEs occur, a participant may resume the trial intervention when the clinical site","confidence":1,"confidence_rate":1},{"cnt":[[247,593],[1820,593],[1820,638],[247,638]],"region":{"top_left_x":247,"top_left_y":592,"width":1573,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2ba58c5e8904bfd8faa2b155fa47f80","type":"text","conversion_output":true,"text":"clinician and the primary care provider (if participant has one) agree that it is appropriate. For","text_display":" clinician and the primary care provider (if participant has one) agree that it is appropriate. For","confidence":1,"confidence_rate":1},{"cnt":[[247,636],[1826,636],[1826,681],[247,681]],"region":{"top_left_x":247,"top_left_y":635,"width":1580,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83e905e0186749ef85d47b2164dd012e","type":"text","conversion_output":true,"text":"mild problems that require temporary cessation of intervention, the clinical site investigator, in","text_display":" mild problems that require temporary cessation of intervention, the clinical site investigator, in","confidence":1,"confidence_rate":1},{"cnt":[[249,681],[1712,681],[1712,724],[249,724]],"region":{"top_left_x":249,"top_left_y":681,"width":1464,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46eb287c6852456090918c7bf06e1314","type":"text","conversion_output":true,"text":"consultation with the clinical site clinician and participant, may agree to reintroduce the","text_display":" consultation with the 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that its continued denial to other study group(s)","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[494,1121],[827,1121],[827,1158],[494,1158]],"region":{"top_left_x":494,"top_left_y":1121,"width":334,"height":38},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"035840942e4b49928bb5d2c20a29166f","type":"text","conversion_output":true,"text":"would be unethical.","text_display":" would be unethical.","confidence":1,"confidence_rate":1},{"cnt":[[443,1164],[1854,1164],[1854,1210],[443,1210]],"region":{"top_left_x":442,"top_left_y":1164,"width":1413,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c92d2f66da14784b2e018a1f4427130","type":"text","conversion_output":true,"text":"3) A very low probability of addressing the study goals within a feasible time frame.","text_display":"\n3) A very low probability of addressing the study goals within a feasible time frame.","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[245,1250],[870,1250],[870,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1250,"width":627,"height":63},"line":21,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"c0d91b382c0f4317b2d0c945dab9de4c","type":"section_header","conversion_output":false,"children_ids":["ed052008f4c546738704994d4fe5b133"],"text":"","text_display":""},{"cnt":[[249,1255],[866,1255],[866,1308],[249,1308]],"region":{"top_left_x":249,"top_left_y":1254,"width":617,"height":55},"line":22,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"ed052008f4c546738704994d4fe5b133","type":"text","conversion_output":true,"parent_id":"c0d91b382c0f4317b2d0c945dab9de4c","text":"Section 15: Data Analyses","text_display":"\n\n\\section*{Section 15: Data Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[245,1328],[1841,1328],[1841,1373],[245,1373]],"region":{"top_left_x":244,"top_left_y":1327,"width":1598,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a0439d31b1e4451bb967ba3dd4a279b","type":"text","conversion_output":true,"text":"Analyses for all aims will be performed according to the intention-to-treat (ITT) paradigm. Prior","text_display":"\n\nAnalyses for all aims will be performed according to the intention-to-treat (ITT) paradigm. Prior","confidence":1,"confidence_rate":1},{"cnt":[[245,1371],[1738,1371],[1738,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1370,"width":1495,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18c458b760444becaaaf8117c9c8ef22","type":"text","conversion_output":true,"text":"to confirmatory analysis, exploratory data analyses will be performed. These exploratory","text_display":" to confirmatory analysis, exploratory data analyses will be performed. These exploratory","confidence":1,"confidence_rate":1},{"cnt":[[247,1418],[1639,1418],[1639,1461],[247,1461]],"region":{"top_left_x":247,"top_left_y":1417,"width":1393,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55a4f68dedc743be8c09db24cad7c176","type":"text","conversion_output":true,"text":"analyses will consist of histograms for continuous outcomes to examine whether a","text_display":" analyses will consist of histograms for continuous outcomes to examine whether a","confidence":1,"confidence_rate":1},{"cnt":[[245,1461],[1863,1461],[1863,1506],[245,1506]],"region":{"top_left_x":244,"top_left_y":1460,"width":1619,"height":47},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d5b89bd411a415fa80dc5568d1ce900","type":"text","conversion_output":true,"text":"transformation is needed to meet modeling assumptions and frequencies for categorical data to","text_display":" transformation is needed to meet modeling assumptions and frequencies for categorical data to","confidence":1,"confidence_rate":1},{"cnt":[[247,1504],[1783,1504],[1783,1549],[247,1549]],"region":{"top_left_x":247,"top_left_y":1503,"width":1537,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8030db89b6540b3b60132066a04b1e5","type":"text","conversion_output":true,"text":"assess whether the data are sparse. With the exception of the statistical test of the primary","text_display":" assess whether the data are sparse. With the exception of the statistical test of the primary","confidence":1,"confidence_rate":1},{"cnt":[[247,1549],[1652,1549],[1652,1592],[247,1592]],"region":{"top_left_x":247,"top_left_y":1549,"width":1406,"height":43},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"766315a7418d4d7ea7f7faefe17e0f1d","type":"text","conversion_output":true,"text":"hypothesis, all statistical tests will be two-sided and will not be adjusted for multiple","text_display":" hypothesis, all statistical tests will be two-sided and will not be adjusted for multiple","confidence":1,"confidence_rate":1},{"cnt":[[247,1592],[1678,1592],[1678,1635],[247,1635]],"region":{"top_left_x":247,"top_left_y":1591,"width":1431,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1be0f467fd345f48667ca2fb74474b0","type":"text","conversion_output":true,"text":"comparisons. As described in greater detail below, the test of the primary hypothesis","text_display":" comparisons. As described in greater detail below, the test of the primary hypothesis","confidence":1,"confidence_rate":1},{"cnt":[[249,1635],[1843,1635],[1843,1680],[249,1680]],"region":{"top_left_x":249,"top_left_y":1634,"width":1595,"height":47},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7fb7ad503484b30b056119ccabbbb8d","type":"text","conversion_output":true,"text":"(comparing the groups with respect to proportion who are community ambulators at 16 weeks)","text_display":" (comparing the groups with respect to proportion who are community ambulators at 16 weeks)","confidence":0.998046875,"confidence_rate":0.9999800508639274},{"cnt":[[247,1680],[1691,1680],[1691,1725],[247,1725]],"region":{"top_left_x":247,"top_left_y":1680,"width":1444,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82598b0bde764458a089357db24d975c","type":"text","conversion_output":true,"text":"will be based on a one-sided 0.025 -level hypothesis test performed at five time points","text_display":" will be based on a one-sided 0.025 -level hypothesis test performed at five time points","confidence":0.9951231479644775,"confidence_rate":0.9999485404537347},{"cnt":[[245,1723],[580,1723],[580,1768],[245,1768]],"region":{"top_left_x":244,"top_left_y":1723,"width":337,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ff3cf5778a64c638c778d3470315fa2","type":"text","conversion_output":true,"text":"throughout the trial.","text_display":" throughout the trial.","confidence":1,"confidence_rate":1},{"cnt":[[277,1809],[625,1809],[625,1863],[277,1863]],"region":{"top_left_x":277,"top_left_y":1808,"width":349,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c73d5aa8fd242b0971842058146b9fe","type":"section_header","conversion_output":false,"children_ids":["eb8fb4dd9f9648a0b4b338586c762582"],"text":"","text_display":""},{"cnt":[[279,1813],[621,1813],[621,1858],[279,1858]],"region":{"top_left_x":279,"top_left_y":1813,"width":342,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb8fb4dd9f9648a0b4b338586c762582","type":"text","conversion_output":true,"parent_id":"8c73d5aa8fd242b0971842058146b9fe","text":"15.1 Primary Aim","text_display":"\n\n\\subsection*{15.1 Primary Aim}","confidence":1,"confidence_rate":1},{"cnt":[[245,1861],[1742,1861],[1742,1904],[245,1904]],"region":{"top_left_x":244,"top_left_y":1860,"width":1499,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f00d80eaef63491182c1d89a7b414aa1","type":"text","conversion_output":true,"text":"The primary aim is to determine if a 16 -week intervention based on aerobic conditioning,","text_display":"\n\nThe primary aim is to determine if a 16 -week intervention based on aerobic conditioning,","confidence":0.9501953125,"confidence_rate":0.9994734611093173},{"cnt":[[247,1904],[1818,1904],[1818,1949],[247,1949]],"region":{"top_left_x":247,"top_left_y":1903,"width":1571,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4a5cc65175e44d2bf4c6c908f1557ac","type":"text","conversion_output":true,"text":"specificity of training, and muscle overload for strengthening (the PUSH intervention) is more","text_display":" specificity of training, and muscle overload for strengthening (the PUSH intervention) is more","confidence":1,"confidence_rate":1},{"cnt":[[247,1946],[1729,1946],[1729,1992],[247,1992]],"region":{"top_left_x":247,"top_left_y":1946,"width":1483,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1182d8d7a00a465182829b6ef0cb200a","type":"text","conversion_output":true,"text":"successful in producing community ambulation at 16 weeks post-randomization than an","text_display":" successful in producing community ambulation at 16 weeks post-randomization than an","confidence":1,"confidence_rate":1},{"cnt":[[247,1989],[1850,1989],[1850,2035],[247,2035]],"region":{"top_left_x":247,"top_left_y":1989,"width":1603,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a76dd00716184ed9827d6293beb2ee95","type":"text","conversion_output":true,"text":"intervention of transcutaneous electrical nerve stimulation, flexibility, and AROM exercises (the","text_display":" intervention of transcutaneous electrical nerve stimulation, flexibility, and AROM exercises (the","confidence":1,"confidence_rate":1},{"cnt":[[249,2037],[1867,2037],[1867,2082],[249,2082]],"region":{"top_left_x":249,"top_left_y":2036,"width":1618,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d80e915d112e47329f0a77c87d1ad55b","type":"text","conversion_output":true,"text":"PULSE intervention). Therefore, the one-sided null hypothesis that the PUSH intervention does","text_display":" PULSE intervention). Therefore, the one-sided null hypothesis that the PUSH intervention does","confidence":1,"confidence_rate":1},{"cnt":[[247,2080],[1843,2080],[1843,2125],[247,2125]],"region":{"top_left_x":247,"top_left_y":2079,"width":1597,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c922f09393b4aef8f47f3591cdbf5c9","type":"text","conversion_output":true,"text":"not result in a higher proportion of community ambulators 16 weeks post-randomization will be","text_display":" not result in a higher proportion of community ambulators 16 weeks post-randomization will be","confidence":1,"confidence_rate":1},{"cnt":[[247,2123],[1717,2123],[1717,2168],[247,2168]],"region":{"top_left_x":247,"top_left_y":2122,"width":1470,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b0e2b288975496989dd1c513d12384f","type":"text","conversion_output":true,"text":"tested. This hypothesis will be tested at five time points based on a Z-statistic (which is","text_display":" tested. This hypothesis will be tested at five time points based on a Z-statistic (which is","confidence":0.998046875,"confidence_rate":0.9999796352611579},{"cnt":[[247,2166],[1811,2166],[1811,2211],[247,2211]],"region":{"top_left_x":247,"top_left_y":2165,"width":1565,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed49f0dcbb0745bb96bd3d7460a646ed","type":"text","conversion_output":true,"text":"equivalent to the square root of the Pearson chi-square statistic). The critical values for each","text_display":" equivalent to the square root of the Pearson chi-square statistic). The critical values for each","confidence":1,"confidence_rate":1},{"cnt":[[247,2209],[1807,2209],[1807,2256],[247,2256]],"region":{"top_left_x":247,"top_left_y":2208,"width":1560,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"960f21aca2f14321adbfd42b2f2fa22e","type":"text","conversion_output":true,"text":"time point were chosen to preserve an overall type-1 error rate of \\(0.025 .^{206}\\) If the exploratory","text_display":" time point were chosen to preserve an overall type-1 error rate of \\(0.025 .^{206}\\) If the exploratory","confidence":0.9941513475496322,"confidence_rate":0.9999466757599716},{"cnt":[[245,2256],[1841,2256],[1841,2299],[245,2299]],"region":{"top_left_x":244,"top_left_y":2255,"width":1598,"height":44},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01b737c6e3784aa29f267b6ecffa8f07","type":"text","conversion_output":true,"text":"analyses reveal data sparseness (expected frequency less than 5 for at least one combination","text_display":" analyses reveal data sparseness (expected frequency less than 5 for at least one combination","confidence":1,"confidence_rate":1},{"cnt":[[247,2299],[1790,2299],[1790,2344],[247,2344]],"region":{"top_left_x":247,"top_left_y":2298,"width":1543,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"434f9013e698427b9c7d2912ce2ef967","type":"text","conversion_output":true,"text":"of treatment group and community ambulation status), Fisher's exact test will be performed","text_display":" of treatment group and community ambulation status), Fisher's exact test will be performed","confidence":1,"confidence_rate":1},{"cnt":[[247,2342],[1811,2342],[1811,2387],[247,2387]],"region":{"top_left_x":247,"top_left_y":2341,"width":1565,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4324eaeec73d42218f2b5f78b5e66667","type":"text","conversion_output":true,"text":"instead of using the chi-square statistic. The difference in proportions with a \\(95 \\%\\) confidence","text_display":" instead of using the chi-square statistic. The difference in proportions with a \\(95 \\%\\) confidence","confidence":1,"confidence_rate":1},{"cnt":[[247,2385],[735,2385],[735,2430],[247,2430]],"region":{"top_left_x":247,"top_left_y":2384,"width":488,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"634aceb85f9a44749913a685f34fb7a3","type":"text","conversion_output":true,"text":"interval will also be reported.","text_display":" interval will also be reported.","confidence":1,"confidence_rate":1},{"cnt":[[249,2587],[660,2587],[660,2623],[249,2623]],"region":{"top_left_x":249,"top_left_y":2586,"width":411,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7584aa9ea104ceb9d4ba8f497be1835","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7dfe883614a4ec3bd5885bc7e7b9bba","type":"page_info","conversion_output":false,"text":"59","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-079","page":79,"lines":[{"cnt":[[245,249],[1824,249],[1824,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1581,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2a279e3fee34fb393d90c98ad15f34e","type":"text","conversion_output":true,"text":"The binary outcome variable will be ability to walk at least 300 meters in six minutes (yes/no).","text_display":"\n\nThe binary outcome variable will be ability to walk at least 300 meters in six minutes (yes/no).","confidence":0.9970703125,"confidence_rate":0.9999717889802962},{"cnt":[[245,296],[1858,296],[1858,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1615,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9106ef020404b6cb9da1f0e60ffa4c8","type":"text","conversion_output":true,"text":"This variable will take the value of 'yes' if the participant was tested with the SMWT and walked","text_display":" This variable will take the value of 'yes' if the participant was tested with the SMWT and walked","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1811,339],[1811,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1568,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"977a409b9f7748f6841d8dfebc3e784a","type":"text","conversion_output":true,"text":"300 m or more in six minutes. This variable will take the value of 'no' if 1) the participant was","text_display":" 300 m or more in six minutes. This variable will take the value of 'no' if 1) the participant was","confidence":0.67578125,"confidence_rate":0.9962025117748654},{"cnt":[[245,382],[1837,382],[1837,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1593,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ac33c4fbbe94a45a9ac6027ab66ee32","type":"text","conversion_output":true,"text":"tested with the SMWT and walked less than 300 m in six minutes or 2 ) the participant was not","text_display":" tested with the SMWT and walked less than 300 m in six minutes or 2 ) the participant was not","confidence":0.6183502674102783,"confidence_rate":0.995475359560473},{"cnt":[[245,425],[1712,425],[1712,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1469,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb1c03ef19e14f1385d164a7398f7401","type":"text","conversion_output":true,"text":"tested with the SMWT (or the participant was tested but not according to protocol) and","text_display":" tested with the SMWT (or the participant was tested but not according to protocol) and","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1794,471],[1794,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1550,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19458db8f06e44848ef4a77acdcbc025","type":"text","conversion_output":true,"text":"adjudication resulted in the participant's being classified as a treatment failure (see 11.5 for","text_display":" adjudication resulted in the participant's being classified as a treatment failure (see 11.5 for","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1654,516],[1654,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1411,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f5bd56db3a34f0994212eb46faf1054","type":"text","conversion_output":true,"text":"description of the adjudication procedure). Participants whose adjudication result is","text_display":" description of the adjudication procedure). Participants whose adjudication result is","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1227,559],[1227,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":983,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d4d1a5bce7b49f0afe330a1230ce8c4","type":"text","conversion_output":true,"text":"'indeterminate' will be excluded from the primary analysis.","text_display":" 'indeterminate' will be excluded from the primary analysis.","confidence":1,"confidence_rate":1},{"cnt":[[245,647],[1738,647],[1738,694],[245,694]],"region":{"top_left_x":244,"top_left_y":646,"width":1495,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"070e94b7950e4002a3df69ad77c3952d","type":"text","conversion_output":true,"text":"In a secondary analysis, an alternative outcome variable will be created to represent the","text_display":"\n\nIn a secondary analysis, an alternative outcome variable will be created to represent the","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1811,692],[1811,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1568,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4ec50db1a7b4d2cba85da6b3e7ce6a2","type":"text","conversion_output":true,"text":"participant's community ambulation status at 16 -week follow-up. This secondary variable will","text_display":" participant's community ambulation status at 16 -week follow-up. This secondary variable will","confidence":0.8697552680969238,"confidence_rate":0.9986193360941723},{"cnt":[[245,735],[1867,735],[1867,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1623,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e48d7209d0341b2b4b7176988d0b860","type":"text","conversion_output":true,"text":"take the value of 'yes' if the participant was tested with the SMWT and walked 300 m or more in","text_display":" take the value of 'yes' if the participant was tested with the SMWT and walked 300 m or more in","confidence":0.9990236759185791,"confidence_rate":0.9999906971766409},{"cnt":[[245,778],[1807,778],[1807,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1563,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27588a30c7384ec98ea89c6d54b17768","type":"text","conversion_output":true,"text":"six minutes. The secondary variable will take the value of 'no' if 1) the participant was tested","text_display":" six minutes. The secondary variable will take the value of 'no' if 1) the participant was tested","confidence":0.88720703125,"confidence_rate":0.9988157817626271},{"cnt":[[245,821],[1803,821],[1803,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1559,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40c51fed922f4db3a15a0c890af4c304","type":"text","conversion_output":true,"text":"with the SMWT and walked less than 300 m in six minutes, 2) the participant was not tested","text_display":" with the SMWT and walked less than 300 m in six minutes, 2) the participant was not tested","confidence":0.9541015625,"confidence_rate":0.9995302588273807},{"cnt":[[245,866],[1798,866],[1798,913],[245,913]],"region":{"top_left_x":244,"top_left_y":865,"width":1555,"height":49},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07447966b5a8437d88692d3000837042","type":"text","conversion_output":true,"text":"with the SMWT and adjudication resulted in the participant's being classified as a treatment","text_display":" with the SMWT and adjudication resulted in the participant's being classified as a treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1863,911],[1863,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1619,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbbecab74d4246ea997b16f446cea8c1","type":"text","conversion_output":true,"text":"failure because of death, sickness, or gait speed \\(<0.6 m / s\\), or 3) the participant was tested with","text_display":" failure because of death, sickness, or gait speed \\(<0.6 m / s\\), or 3) the participant was tested with","confidence":0.9765625,"confidence_rate":0.9997863604222276},{"cnt":[[245,954],[1785,954],[1785,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1542,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bda5bb6126004384878366e742b469c9","type":"text","conversion_output":true,"text":"the SMWT but not according to protocol and adjudication resulted in the participant's being","text_display":" the SMWT but not according to protocol and adjudication resulted in the participant's being","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1876,997],[1876,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1632,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4690320e21b4c3c815efe57a3d07939","type":"text","conversion_output":true,"text":"classified as a treatment failure, whatever the reason. The secondary variable will take the value","text_display":" classified as a treatment failure, whatever the reason. The secondary variable will take the value","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1835,1042],[1835,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1591,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b58a022194af4299a2d6df01f9e4680e","type":"text","conversion_output":true,"text":"of 'missing' if 1) the participant was not tested with the SMWT and adjudication resulted in the","text_display":" of 'missing' if 1) the participant was not tested with the SMWT and adjudication resulted in the","confidence":0.99658203125,"confidence_rate":0.9999661013334881},{"cnt":[[245,1087],[1871,1087],[1871,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1628,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5010f42bd6e745e8aa44d792d117a979","type":"text","conversion_output":true,"text":"participant's being classified as a treatment failure based only on self- or proxy-reported walking","text_display":" participant's being classified as a treatment failure based only on self- or proxy-reported walking","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1837,1130],[1837,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1593,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99703d853b3c4b5da8631a17f53c0854","type":"text","conversion_output":true,"text":"limitation or 2) the participant was not tested with the SMWT (or the participant was tested but","text_display":" limitation or 2) the participant was not tested with the SMWT (or the participant was tested but","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[245,1173],[1762,1173],[1762,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1518,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"890d0aa0f7c44412b80f98a37eb1d642","type":"text","conversion_output":true,"text":"not according to protocol) and adjudication resulted in the participant's being classified as","text_display":" not according to protocol) and adjudication resulted in the participant's being classified as","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1863,1216],[1863,1263],[245,1263]],"region":{"top_left_x":244,"top_left_y":1216,"width":1619,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7612dd70c60f463aaf0a88cf8df4351d","type":"text","conversion_output":true,"text":"'indeterminate'. All participants, including those with a missing value for the alternative outcome","text_display":" 'indeterminate'. All participants, including those with a missing value for the alternative outcome","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,1261],[1824,1261],[1824,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1261,"width":1581,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7633877405ce478ba50dbaaaf8da6469","type":"text","conversion_output":true,"text":"variable, will be included in the secondary analysis. To be consistent with the principle of ITT,","text_display":" variable, will be included in the secondary analysis. To be consistent with the principle of ITT,","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1562,1306],[1562,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1318,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b1affd9e1994278960e753949b65604","type":"text","conversion_output":true,"text":"weighted estimated equations (described below) will be used for this analysis.","text_display":" weighted estimated equations (described below) will be used for this analysis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[1850,1392],[1850,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1606,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"150b7a67ca8749f8b29cf102692848e0","type":"text","conversion_output":true,"text":"Study site will be investigated as a modifier of the effect of the intervention by testing a site-by-","text_display":"\n\nStudy site will be investigated as a modifier of the effect of the intervention by testing a site-by","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,1437],[1781,1437],[1781,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1437,"width":1538,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad912bd5a3164d99a459b9986165474d","type":"text","conversion_output":true,"text":"intervention interaction term. If study site is an effect modifier, we will report 1 ) site-specific","text_display":"intervention interaction term. If study site is an effect modifier, we will report 1 ) site-specific","confidence":0.5255420599132776,"confidence_rate":0.994060992580862},{"cnt":[[245,1482],[1714,1482],[1714,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1482,"width":1471,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b5f6c1908c646569864c570c6ba48fe","type":"text","conversion_output":true,"text":"treatment effects and 2) a summary measure of treatment effect using standardization.","text_display":" treatment effects and 2) a summary measure of treatment effect using standardization.","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[245,1525],[1781,1525],[1781,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1538,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d490d2fbc4634361ad6bb092fa260d57","type":"text","conversion_output":true,"text":"Standardization will be accomplished using inverse probability of treatment weighting (as a","text_display":" Standardization will be accomplished using inverse probability of treatment weighting (as a","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1177,1568],[1177,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":934,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd67736f214841cbb7a3437dbd4ec8df","type":"text","conversion_output":true,"text":"function of study site) in a marginal structural model. \\({ }^{207}\\)","text_display":" function of study site) in a marginal structural model. \\({ }^{207}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1858,1659],[1858,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1615,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2b3b9f68b1645e78794816df06adc1d","type":"text","conversion_output":true,"text":"In the fall of 2014, a decision was made to modify the frequency of intervention visits during the","text_display":"\n\nIn the fall of 2014, a decision was made to modify the frequency of intervention visits during the","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[1794,1702],[1794,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":1550,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99cea04541b94b6cbce4fe80f1056938","type":"text","conversion_output":true,"text":"first 8 weeks from 3 per week to 2 per week. The number of sessions per week in the first 8","text_display":" first 8 weeks from 3 per week to 2 per week. The number of sessions per week in the first 8","confidence":0.99755859375,"confidence_rate":0.9999764965133096},{"cnt":[[245,1745],[1835,1745],[1835,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1744,"width":1591,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"098ad627d1a04175825f6f782850c5f2","type":"text","conversion_output":true,"text":"weeks will also be assessed as a potential effect modifier, using the methods described in the","text_display":" weeks will also be assessed as a potential effect modifier, using the methods described in the","confidence":0.9970703125,"confidence_rate":0.9999703642024339},{"cnt":[[245,1788],[1846,1788],[1846,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1602,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c9726da5e6b48e599debd9a78253755","type":"text","conversion_output":true,"text":"previous paragraph. If we find strong evidence that the number of sessions per week modifies","text_display":" previous paragraph. If we find strong evidence that the number of sessions per week modifies","confidence":1,"confidence_rate":1},{"cnt":[[245,1833],[1803,1833],[1803,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1832,"width":1559,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e95229c476b4411e8a9ac571020d2fb8","type":"text","conversion_output":true,"text":"the comparison of the intervention groups, we will report treatment effects separately for the","text_display":" the comparison of the intervention groups, we will report treatment effects separately for the","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1854,1878],[1854,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1877,"width":1611,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba55bc7df58248e9a1e1f899b47ffcdd","type":"text","conversion_output":true,"text":"period when there were two sessions per week and the period when there were three sessions","text_display":" period when there were two sessions per week and the period when there were three sessions","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[419,1921],[419,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":175,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"839a2a0efcd3415495abf4b0d7ff58d5","type":"text","conversion_output":true,"text":"per week.","text_display":" per week.","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1835,2007],[1835,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1591,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8758b033310d412d873a0fa1f856510d","type":"text","conversion_output":true,"text":"This change in number of sessions also affords us an opportunity to assess the impact of visit","text_display":"\n\nThis change in number of sessions also affords us an opportunity to assess the impact of visit","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1760,2054],[1760,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2053,"width":1516,"height":47},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb4a94b11697457c88a449cf4f18a1ab","type":"text","conversion_output":true,"text":"frequency on the intervention outcomes as a secondary analysis. To do so, assuming no","text_display":" frequency on the intervention outcomes as a secondary analysis. To do so, assuming no","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1721,2097],[1721,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1477,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccd3d5e53d264af3a1c84d033969c77d","type":"text","conversion_output":true,"text":"significant interaction between site and intervention group, we will assess the statistical","text_display":" significant interaction between site and intervention group, we will assess the statistical","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1760,2140],[1760,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2139,"width":1516,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c748358456f4c93889550ce9dfc0070","type":"text","conversion_output":true,"text":"significance of the effect of number of sessions. If there is significant interaction between","text_display":" significance of the effect of number of sessions. If there is significant interaction between","confidence":0.99169921875,"confidence_rate":0.9999149482642569},{"cnt":[[245,2183],[1867,2183],[1867,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2182,"width":1623,"height":49},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc1c79b8c2f54a58825406d82a49ff2a","type":"text","conversion_output":true,"text":"number of sessions and intervention group, then we will compare the outcomes obtained during","text_display":" number of sessions and intervention group, then we will compare the outcomes obtained during","confidence":1,"confidence_rate":1},{"cnt":[[245,2228],[1824,2228],[1824,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2227,"width":1581,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f79bce9fab4a4de3b27961f9773e02be","type":"text","conversion_output":true,"text":"the period with two sessions per week in the first 8 weeks to those obtained during the period","text_display":" the period with two sessions per week in the first 8 weeks to those obtained during the period","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1717,2273],[1717,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1473,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a95f364d64ea45d586c4e355dfc53d10","type":"text","conversion_output":true,"text":"with three sessions per week in the first 8 weeks separately in each intervention group.","text_display":" with three sessions per week in the first 8 weeks separately in each intervention group.","confidence":1,"confidence_rate":1},{"cnt":[[245,2359],[1768,2359],[1768,2406],[245,2406]],"region":{"top_left_x":244,"top_left_y":2358,"width":1525,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"558be7b967034a33be69acbe2356952c","type":"text","conversion_output":true,"text":"In addition, a series of analyses will be performed to examine the differential impact of the","text_display":"\n\nIn addition, a series of analyses will be performed to examine the differential impact of the","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1760,2402],[1760,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1516,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ed4b99574534dafaca87a5e72d27534","type":"text","conversion_output":true,"text":"PUSH intervention relative to the PULSE intervention in subgroups defined by participant","text_display":" PUSH intervention relative to the PULSE intervention in subgroups defined by participant","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37a668bc23584cdda65f5febc7452880","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1833,2587],[1886,2587],[1886,2628],[1833,2628]],"region":{"top_left_x":1832,"top_left_y":2586,"width":55,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a00623ad9624c1594b341fd5edab36a","type":"page_info","conversion_output":false,"text":"60","text_display":"","confidence":0.99951171875,"confidence_rate":0.9997558295653994}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-080","page":80,"lines":[{"cnt":[[245,249],[1837,249],[1837,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1593,"height":50},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe884db8b9794fcfafb5f4d3a062ee6b","type":"text","conversion_output":true,"text":"characteristics. To do this, a variable-by-intervention interaction term will be tested for each of","text_display":"\ncharacteristics. To do this, a variable-by-intervention interaction term will be tested for each of","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[638,296],[638,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":395,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3906c46357ba41bda30b8a17e17f5d6e","type":"text","conversion_output":true,"text":"the following variables:","text_display":" the following variables:","confidence":1,"confidence_rate":1},{"cnt":[[309,339],[509,339],[509,380],[309,380]],"region":{"top_left_x":309,"top_left_y":339,"width":201,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d73d99bd937c48d7b724d763e39922c6","type":"text","conversion_output":true,"text":"1. Gender","text_display":"\n1. Gender","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1182,382],[1182,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":877,"height":50},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a9c1edd023a4de283a6c02e6e76f8ec","type":"text","conversion_output":true,"text":"2. Age at baseline ( \\(\\geq 85\\) years versus \\(60-84\\) years)","text_display":"\n2. Age at baseline ( \\(\\geq 85\\) years versus \\(60-84\\) years)","confidence":0.9794921875,"confidence_rate":0.9996603688739831},{"cnt":[[305,425],[1510,425],[1510,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1206,"height":50},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64a3a3fe9c564525ad5f96f861da5d3d","type":"text","conversion_output":true,"text":"3. Baseline depression (CES-D score \\(\\geq 16\\) versus CES-D score < 16)","text_display":"\n3. Baseline depression (CES-D score \\(\\geq 16\\) versus CES-D score < 16)","confidence":0.7541427612304688,"confidence_rate":0.9960885919179484},{"cnt":[[305,471],[1852,471],[1852,518],[305,518]],"region":{"top_left_x":305,"top_left_y":470,"width":1547,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3967ccaf3074f44abc9cd959a9d8139","type":"text","conversion_output":true,"text":"4. Baseline balance confidence (with median Activities-Specific Balance Confidence scale","text_display":"\n4. Baseline balance confidence (with median Activities-Specific Balance Confidence scale","confidence":1,"confidence_rate":1},{"cnt":[[370,516],[1156,516],[1156,561],[370,561]],"region":{"top_left_x":369,"top_left_y":515,"width":787,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f658c9904d894d71b86db3c21fe292d2","type":"text","conversion_output":true,"text":"score as the cutpoint to define the subgroups)","text_display":" score as the cutpoint to define the subgroups)","confidence":1,"confidence_rate":1},{"cnt":[[305,559],[1648,559],[1648,604],[305,604]],"region":{"top_left_x":305,"top_left_y":558,"width":1343,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11bf222795514a4584ed52ad3bfa72a7","type":"text","conversion_output":true,"text":"5. Baseline nutritional status (MNA®-SF score \\(<8\\) versus MNA®-SF score \\(\\geq 8\\) )","text_display":"\n5. Baseline nutritional status (MNA®-SF score \\(<8\\) versus MNA®-SF score \\(\\geq 8\\) )","confidence":0.9709303747407034,"confidence_rate":0.9996529953029181},{"cnt":[[305,602],[1485,602],[1485,647],[305,647]],"region":{"top_left_x":305,"top_left_y":601,"width":1180,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e95aa47efed347e481eb5c0a72dfc6f5","type":"text","conversion_output":true,"text":"6. Baseline cognitive status (3MS score \\(<91\\) versus 3 MS score \\(\\geq 91\\) )","text_display":"\n6. Baseline cognitive status (3MS score \\(<91\\) versus 3 MS score \\(\\geq 91\\) )","confidence":0.8948591815992586,"confidence_rate":0.9986624746579315},{"cnt":[[245,647],[1869,647],[1869,694],[245,694]],"region":{"top_left_x":244,"top_left_y":646,"width":1626,"height":48},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52d6bd27abca4dffa2b85e6e6d79288d","type":"text","conversion_output":true,"text":"If the interaction term for any of these subgroup variables is significant, results will be presented","text_display":"\n\nIf the interaction term for any of these subgroup variables is significant, results will be presented","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1005,692],[1005,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":762,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37060280c3c347e8aedc621295ac97e0","type":"text","conversion_output":true,"text":"separately in strata of the subgroup variable.","text_display":" separately in strata of the subgroup variable.","confidence":1,"confidence_rate":1},{"cnt":[[271,773],[819,773],[819,836],[271,836]],"region":{"top_left_x":270,"top_left_y":773,"width":549,"height":63},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39a93f16ae7a4c419b0268eb3edf304f","type":"section_header","conversion_output":false,"children_ids":["1dd5ab82ea2e407da4867102b29c0a2b"],"text":"","text_display":""},{"cnt":[[279,778],[814,778],[814,829],[279,829]],"region":{"top_left_x":279,"top_left_y":777,"width":536,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1dd5ab82ea2e407da4867102b29c0a2b","type":"text","conversion_output":true,"parent_id":"39a93f16ae7a4c419b0268eb3edf304f","text":"15.2 Secondary Objectives","text_display":"\n\n\\subsection*{15.2 Secondary Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[367,864],[1063,864],[1063,920],[367,920]],"region":{"top_left_x":367,"top_left_y":863,"width":697,"height":57},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97b5a8b596504120b7e6ce4710ff8db0","type":"section_header","conversion_output":false,"children_ids":["bfc387f88a9a40d3b461863e80a6a284"],"text":"","text_display":""},{"cnt":[[374,868],[1059,868],[1059,917],[374,917]],"region":{"top_left_x":373,"top_left_y":867,"width":687,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfc387f88a9a40d3b461863e80a6a284","type":"text","conversion_output":true,"parent_id":"97b5a8b596504120b7e6ce4710ff8db0","text":"15.2.1 Delayed and Sustained Effects","text_display":"\n\n\\subsection*{15.2.1 Delayed and Sustained Effects}","confidence":1,"confidence_rate":1},{"cnt":[[245,913],[1841,913],[1841,960],[245,960]],"region":{"top_left_x":244,"top_left_y":913,"width":1598,"height":48},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf7e4f801f7f463f8f262605b0f85adb","type":"text","conversion_output":true,"text":"Generalized estimating equations (GEEs) \\({ }^{208}\\) will be used to examine whether the proportion of","text_display":"\n\nGeneralized estimating equations (GEEs) \\({ }^{208}\\) will be used to examine whether the proportion of","confidence":0.972326579503715,"confidence_rate":0.9997401861296097},{"cnt":[[245,958],[1837,958],[1837,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":958,"width":1593,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfd9542c7b524ca28ea55ef5cb6377a9","type":"text","conversion_output":true,"text":"community ambulators differs between the PUSH and PULSE interventions at 40 weeks post-","text_display":" community ambulators differs between the PUSH and PULSE interventions at 40 weeks post","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1841,1001],[1841,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1598,"height":50},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23776fd23efc4ba69eaecfdeba8f4cfb","type":"text","conversion_output":true,"text":"randomization and, for the subset of participants who were followed for 40 weeks, whether the","text_display":"randomization and, for the subset of participants who were followed for 40 weeks, whether the","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1833,1044],[1833,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":1589,"height":50},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa789b6a6ccb446b9bbf8ca674c5c821","type":"text","conversion_output":true,"text":"difference in proportions at 40 weeks changed from the difference in proportions at 16 weeks.","text_display":" difference in proportions at 40 weeks changed from the difference in proportions at 16 weeks.","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,1089],[1811,1089],[1811,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1089,"width":1568,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"397f789d8eb645d788d88ddd7be9bf37","type":"text","conversion_output":true,"text":"GEE will be used for this analysis because the data are longitudinal and, unlike in likelihood-","text_display":" GEE will be used for this analysis because the data are longitudinal and, unlike in likelihood","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[1729,1134],[1729,1182],[245,1182]],"region":{"top_left_x":244,"top_left_y":1134,"width":1486,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b187793306b74f2ab68d2e9172642111","type":"text","conversion_output":true,"text":"based methods, the estimates are robust to misspecification of the working model (e.g.,","text_display":"based methods, the estimates are robust to misspecification of the working model (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1729,1177],[1729,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1177,"width":1486,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9e86945d4fb4e15898bcde190f13444","type":"text","conversion_output":true,"text":"binomial, normal, etc.). This approach accounts for intra-participant correlation between","text_display":" binomial, normal, etc.). This approach accounts for intra-participant correlation between","confidence":1,"confidence_rate":1},{"cnt":[[245,1222],[1828,1222],[1828,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1222,"width":1585,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e3306a9a99c43aa8722bdd41b89ea05","type":"text","conversion_output":true,"text":"repeated measures. With the use of GEEs we will be able to relate outcomes, at specific time","text_display":" repeated measures. With the use of GEEs we will be able to relate outcomes, at specific time","confidence":0.998046875,"confidence_rate":0.9999798452048033},{"cnt":[[245,1265],[1835,1265],[1835,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1265,"width":1591,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93835bd166f746ad9d57f87f3c7d668d","type":"text","conversion_output":true,"text":"points, to treatment group. For all analyses using GEE, the empirical variance estimate will be","text_display":" points, to treatment group. For all analyses using GEE, the empirical variance estimate will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1876,1311],[1876,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1310,"width":1632,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8506b01138de4b3cbc616606ce1169a1","type":"text","conversion_output":true,"text":"used because it is robust to model misspecification. The longitudinal model for this aim will be fit","text_display":" used because it is robust to model misspecification. The longitudinal model for this aim will be fit","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1369,1354],[1369,1401],[245,1401]],"region":{"top_left_x":244,"top_left_y":1353,"width":1125,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b79afb2ab774be0ae0ae3f2b8acb082","type":"text","conversion_output":true,"text":"using a binomial working model and is expressed by the equation:","text_display":" using a binomial working model and is expressed by the equation:","confidence":1,"confidence_rate":1},{"cnt":[[301,1435],[973,1435],[973,1493],[301,1493]],"region":{"top_left_x":300,"top_left_y":1435,"width":674,"height":59},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c945f5ff34f4508b8de4622db3ef224","type":"math","conversion_output":true,"text":"\\[\n\\operatorname{Logit}(p)=a+b 1 \\text { X + b2 t40 + b3 Xt40, }\n\\]","text_display":"\n\\[\n\\operatorname{Logit}(p)=a+b 1 \\text { X + b2 t40 + b3 Xt40, }\n\\]","confidence":0.5629450143314898,"confidence_rate":0.9864128331109884},{"cnt":[[1371,1439],[1493,1439],[1493,1489],[1371,1489]],"region":{"top_left_x":1370,"top_left_y":1439,"width":124,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f638bfdc1f64593af3fbf380016e3cc","type":"equation_number","conversion_output":false,"text":"(Eq. 1)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,1525],[1794,1525],[1794,1575],[243,1575]],"region":{"top_left_x":242,"top_left_y":1525,"width":1552,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc1dc0010a3741f49c41d8bae17eb632","type":"text","conversion_output":true,"text":"where \\(p\\) is the probability of a particular outcome, \\(\\operatorname{Logit}(p)=\\ln (p /(1-p)), X\\) is the intervention","text_display":"\nwhere \\(p\\) is the probability of a particular outcome, \\(\\operatorname{Logit}(p)=\\ln (p /(1-p)), X\\) is the intervention","confidence":0.9726948551863757,"confidence_rate":0.9997506179627651},{"cnt":[[245,1573],[1867,1573],[1867,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1572,"width":1623,"height":51},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c86c5f08ba5d4e0e87edd3e10e851d6b","type":"text","conversion_output":true,"text":"indicator (1/0) variable; b1 is the treatment effect at 16 weeks; t40 is the 40-week follow-up time","text_display":" indicator (1/0) variable; b1 is the treatment effect at 16 weeks; t40 is the 40-week follow-up time","confidence":0.4944092440173131,"confidence_rate":0.9934385213589406},{"cnt":[[245,1618],[1824,1618],[1824,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1617,"width":1581,"height":49},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f9da856bbb045e484d596f59bd59286","type":"text","conversion_output":true,"text":"post-randomization indicator ( \\(0=16\\) weeks; \\(1=40\\) weeks); and Xt 40 is the intervention-by-time","text_display":" post-randomization indicator ( \\(0=16\\) weeks; \\(1=40\\) weeks); and Xt 40 is the intervention-by-time","confidence":0.9435326455975912,"confidence_rate":0.9994668915634256},{"cnt":[[245,1661],[1732,1661],[1732,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1660,"width":1488,"height":49},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"892309d7a2c644c999a8a512cd829f86","type":"text","conversion_output":true,"text":"interaction variable. The fitted coefficients in Eq. 1 provide estimates of the proportion of","text_display":" interaction variable. The fitted coefficients in Eq. 1 provide estimates of the proportion of","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1710,1706],[1710,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1705,"width":1467,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32e578526b244ac9afe1ab24a502d6f2","type":"text","conversion_output":true,"text":"community ambulators in the PUSH vs PULSE interventions at 16 and 40 weeks post-","text_display":" community ambulators in the PUSH vs PULSE interventions at 16 and 40 weeks post","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1850,1749],[1850,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1606,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f8269a2e35249a2b420a45b3e405e4d","type":"text","conversion_output":true,"text":"randomization. To test the null hypothesis of equal proportion of community ambulators in both","text_display":"randomization. To test the null hypothesis of equal proportion of community ambulators in both","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1841,1792],[1841,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1598,"height":51},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d41b972a60dc4dfa99f5fc54ff8a5f86","type":"text","conversion_output":true,"text":"groups at 40 weeks post-randomization, we will test the null hypothesis \\(H _{0}:( b 1+ b 3)=0\\) using a","text_display":" groups at 40 weeks post-randomization, we will test the null hypothesis \\(H _{0}:( b 1+ b 3)=0\\) using a","confidence":0.9809660911560059,"confidence_rate":0.9998385224035797},{"cnt":[[245,1835],[1865,1835],[1865,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1621,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56c9c55e66ba4f5597f3c8301f34d9c4","type":"text","conversion_output":true,"text":"two-sided test with type I error of 0.05 . This test will be performed regardless of results from the","text_display":" two-sided test with type I error of 0.05 . This test will be performed regardless of results from the","confidence":0.9970703125,"confidence_rate":0.9999730830463522},{"cnt":[[245,1882],[1837,1882],[1837,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1882,"width":1593,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95b6040983754bb4b174ff3b9bf2df90","type":"text","conversion_output":true,"text":"primary aim. However, the interpretation of results from this test will depend on those from the","text_display":" primary aim. However, the interpretation of results from this test will depend on those from the","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1815,1925],[1815,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1572,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e14de8796b8e4d27b6c9455ddff9625c","type":"text","conversion_output":true,"text":"primary aim. If there is evidence for a difference in proportion of community ambulators at 16","text_display":" primary aim. If there is evidence for a difference in proportion of community ambulators at 16","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,1968],[1820,1968],[1820,2015],[245,2015]],"region":{"top_left_x":244,"top_left_y":1967,"width":1576,"height":49},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ee3fe48fb8646e0a18b59e1fca792dd","type":"text","conversion_output":true,"text":"weeks, then rejecting this hypothesis can be interpreted as evidence for a sustained effect of","text_display":" weeks, then rejecting this hypothesis can be interpreted as evidence for a sustained effect of","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1772,2011],[1772,2058],[245,2058]],"region":{"top_left_x":244,"top_left_y":2010,"width":1529,"height":49},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02e8fc57e41a42e08284cf547808a841","type":"text","conversion_output":true,"text":"the PUSH intervention on community ambulation at 40 weeks; if there is no evidence for a","text_display":" the PUSH intervention on community ambulation at 40 weeks; if there is no evidence for a","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1811,2054],[1811,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2053,"width":1568,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3f56f6b68c54b0dbb36d7882adf363c","type":"text","conversion_output":true,"text":"difference in proportion of community ambulators at 16 weeks, then rejecting this hypothesis","text_display":" difference in proportion of community ambulators at 16 weeks, then rejecting this hypothesis","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,2101],[1794,2101],[1794,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2101,"width":1550,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d14dcd2a006148cc8baefa1842894905","type":"text","conversion_output":true,"text":"can be interpreted as evidence for a delayed effect of the PUSH intervention on community","text_display":" can be interpreted as evidence for a delayed effect of the PUSH intervention on community","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1704,2144],[1704,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1460,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d33ad8e187b047dc924108a5e73180c3","type":"text","conversion_output":true,"text":"ambulation at 40 weeks. We are also interested in describing the trends in community","text_display":" ambulation at 40 weeks. We are also interested in describing the trends in community","confidence":1,"confidence_rate":1},{"cnt":[[245,2187],[1712,2187],[1712,2234],[245,2234]],"region":{"top_left_x":244,"top_left_y":2187,"width":1469,"height":48},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c466c5a675d54159a481f297cbe5ec64","type":"text","conversion_output":true,"text":"ambulation from 16 to 40 weeks post-randomization in both groups. To assess the null","text_display":" ambulation from 16 to 40 weeks post-randomization in both groups. To assess the null","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1878,2230],[1878,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1634,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c1a836e351946a4b107c5804cfe8ddd","type":"text","conversion_output":true,"text":"hypothesis of no change in the between-group difference of proportion of community ambulators","text_display":" hypothesis of no change in the between-group difference of proportion of community ambulators","confidence":1,"confidence_rate":1},{"cnt":[[245,2275],[1861,2275],[1861,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2275,"width":1617,"height":48},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e941b1ff25fe4ab8942c3da7b22f1ed5","type":"text","conversion_output":true,"text":"between 16 and 40 weeks post-randomization, we will test the null hypothesis \\(H _{0}\\) : \\(b 3=0\\) using a","text_display":" between 16 and 40 weeks post-randomization, we will test the null hypothesis \\(H _{0}\\) : \\(b 3=0\\) using a","confidence":0.6241201397047461,"confidence_rate":0.9962055044778158},{"cnt":[[245,2320],[1796,2320],[1796,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2320,"width":1553,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcdedcaba7b14fbdb8bcac8563a6b345","type":"text","conversion_output":true,"text":"Wald chi-square test with type I error of 0.05 . All treatment effects will be reported with their","text_display":" Wald chi-square test with type I error of 0.05 . All treatment effects will be reported with their","confidence":0.99658203125,"confidence_rate":0.9999677003013677},{"cnt":[[245,2363],[872,2363],[872,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2363,"width":629,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8efc98666194dc7bfa7a25edb4f36c0","type":"text","conversion_output":true,"text":"respective \\(95 \\%\\) confidence intervals.","text_display":" respective \\(95 \\%\\) confidence intervals.","confidence":0.7764761447906494,"confidence_rate":0.9942667400803143},{"cnt":[[245,2449],[1876,2449],[1876,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2449,"width":1632,"height":50},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6b1ab959f7c49809e40ac66a406df0b","type":"text","conversion_output":true,"text":"A similar approach will be used to examine delayed and sustained effects for the secondary and","text_display":"\n\nA similar approach will be used to examine delayed and sustained effects for the secondary and","confidence":1,"confidence_rate":1},{"cnt":[[245,2585],[660,2585],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2584,"width":416,"height":40},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a933ee2b5934a68a3c6b74f733aa03b","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1830,2587],[1886,2587],[1886,2628],[1830,2628]],"region":{"top_left_x":1830,"top_left_y":2586,"width":57,"height":42},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7dc4c3e530494795bd0ae450886f0646","type":"page_info","conversion_output":false,"text":"61","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-081","page":81,"lines":[{"cnt":[[245,251],[844,251],[844,299],[245,299]],"region":{"top_left_x":244,"top_left_y":251,"width":601,"height":48},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9e1e7d2ee7143ee89e8eff8eaf60199","type":"text","conversion_output":true,"text":"tertiary outcomes described below.","text_display":"\ntertiary outcomes described below.","confidence":1,"confidence_rate":1},{"cnt":[[370,335],[1130,335],[1130,387],[370,387]],"region":{"top_left_x":369,"top_left_y":335,"width":762,"height":52},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d47696be3c44d8a8e3ced531a816af4","type":"section_header","conversion_output":false,"children_ids":["99251c8ed03242c698683146a66bf808"],"text":"","text_display":""},{"cnt":[[374,339],[1126,339],[1126,385],[374,385]],"region":{"top_left_x":373,"top_left_y":339,"width":753,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99251c8ed03242c698683146a66bf808","type":"text","conversion_output":true,"parent_id":"2d47696be3c44d8a8e3ced531a816af4","text":"15.2.2 Secondary and Tertiary Outcomes","text_display":"\n\n\\subsection*{15.2.2 Secondary and Tertiary Outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1764,382],[1764,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1520,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bbadf554bb445069ff25f1bba083569","type":"text","conversion_output":true,"text":"Secondary outcomes include five variables (endurance, dynamic balance, walking speed,","text_display":"\n\nSecondary outcomes include five variables (endurance, dynamic balance, walking speed,","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1807,425],[1807,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1563,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0c0e24447324ddda5c84ca5eccf8387","type":"text","conversion_output":true,"text":"quadriceps strength, and lower extremity function) that are hypothesized to be precursors to","text_display":" quadriceps strength, and lower extremity function) that are hypothesized to be precursors to","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1854,473],[1854,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1611,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b369934095d94120ba73fd6634345a02","type":"text","conversion_output":true,"text":"community ambulation. In addition, we will examine the difference between the treatments with","text_display":" community ambulation. In addition, we will examine the difference between the treatments with","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1807,516],[1807,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1563,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3d725d688864f428e996bc2860953ec","type":"text","conversion_output":true,"text":"respect to the following tertiary outcomes: ADLs, balance confidence, quality of life, physical","text_display":" respect to the following tertiary outcomes: ADLs, balance confidence, quality of life, physical","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1876,559],[1876,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":1632,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4dc1ce5af83d4f13be1ffcfaa78fa53f","type":"text","conversion_output":true,"text":"activity, lower extremity physical performance, depressive symptoms, increase of \\(\\geq 50\\) meters in","text_display":" activity, lower extremity physical performance, depressive symptoms, increase of \\(\\geq 50\\) meters in","confidence":0.9990236759185791,"confidence_rate":0.9999904235654993},{"cnt":[[245,602],[1781,602],[1781,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1538,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed6849bde03b4a2ba32920ac2bbfe810","type":"text","conversion_output":true,"text":"distance walked in six minutes, cognitive status, and nutritional status. GEE will be used to","text_display":" distance walked in six minutes, cognitive status, and nutritional status. GEE will be used to","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1867,645],[1867,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1623,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9e025871018420f909b178337909f57","type":"text","conversion_output":true,"text":"compare the PUSH and PULSE interventions at 16 and 40 weeks post-randomization. Increase","text_display":" compare the PUSH and PULSE interventions at 16 and 40 weeks post-randomization. Increase","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1863,692],[1863,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1619,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51a7f540de724954ad6d451b05bdbedb","type":"text","conversion_output":true,"text":"of \\(\\geq 50 m\\) in distance walked, a dichotomous outcome, will be analyzed using the same method","text_display":" of \\(\\geq 50 m\\) in distance walked, a dichotomous outcome, will be analyzed using the same method","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1757,735],[1757,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1514,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"733b953b39f7459899f87ddba83cb886","type":"text","conversion_output":true,"text":"as the primary outcome. All of the other secondary and tertiary outcomes are continuous;","text_display":" as the primary outcome. All of the other secondary and tertiary outcomes are continuous;","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1772,778],[1772,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1529,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bacc3123311449b8d47ab7ffc9e7bce","type":"text","conversion_output":true,"text":"therefore, a normal working model will be used to estimate the parameters in the following","text_display":" therefore, a normal working model will be used to estimate the parameters in the following","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[410,821],[410,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":167,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db0f3a0ad7ca46858156c9de1bf08ea4","type":"text","conversion_output":true,"text":"equation:","text_display":" equation:","confidence":1,"confidence_rate":1},{"cnt":[[423,864],[1308,864],[1308,922],[423,922]],"region":{"top_left_x":423,"top_left_y":863,"width":886,"height":59},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37cb651889fd40999765f3527d0469cd","type":"math","conversion_output":true,"text":"\\[\n\\mu=a+b 1 X+b 2 t 16+b 3 t 40+b 4 X t 16+b 5 X t 40\n\\]","text_display":"\n\\[\n\\mu=a+b 1 X+b 2 t 16+b 3 t 40+b 4 X t 16+b 5 X t 40\n\\]","confidence":0.8553786456709629,"confidence_rate":0.9952775180389615},{"cnt":[[1371,868],[1493,868],[1493,917],[1371,917]],"region":{"top_left_x":1370,"top_left_y":867,"width":124,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6d2a098ff924580b8d24ab50f500f66","type":"equation_number","conversion_output":false,"text":"(Eq. 2)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,958],[1820,958],[1820,1008],[243,1008]],"region":{"top_left_x":242,"top_left_y":958,"width":1578,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7868b10c4fc4c9d9e833e809a8d7693","type":"text","conversion_output":true,"text":"where \\(\\mu\\) is the mean of a particular outcome, X is the intervention indicator ( \\(1 / 0\\) ) variable; t16","text_display":"\nwhere \\(\\mu\\) is the mean of a particular outcome, X is the intervention indicator ( \\(1 / 0\\) ) variable; t16","confidence":0.7701279206230255,"confidence_rate":0.9977312848484537},{"cnt":[[245,1003],[1871,1003],[1871,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1003,"width":1628,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73afd6e5a4cf445caad979b2f042ff9f","type":"text","conversion_output":true,"text":"and t40 are the 16- and 40-week follow-up time post-randomization indicators, respectively; and","text_display":" and t40 are the 16- and 40-week follow-up time post-randomization indicators, respectively; and","confidence":0.8386135101318359,"confidence_rate":0.9982414946452243},{"cnt":[[245,1048],[1755,1048],[1755,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1048,"width":1512,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a05772a0c734f7c9617a9c3c3cdbdfd","type":"text","conversion_output":true,"text":"Xt16 and Xt40 are the intervention-by-time interaction variables. This model accounts for","text_display":" Xt16 and Xt40 are the intervention-by-time interaction variables. This model accounts for","confidence":0.6259765625,"confidence_rate":0.9950289674410256},{"cnt":[[245,1091],[1762,1091],[1762,1141],[245,1141]],"region":{"top_left_x":244,"top_left_y":1091,"width":1518,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"233320aca27a4729943e877af71893bf","type":"text","conversion_output":true,"text":"outcomes at three time points: baseline, 16 weeks, and 40 weeks post-randomization. By","text_display":" outcomes at three time points: baseline, 16 weeks, and 40 weeks post-randomization. By","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[1876,1134],[1876,1182],[245,1182]],"region":{"top_left_x":244,"top_left_y":1134,"width":1632,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e151ecbb3a374b1f9b8e3663272cf4c5","type":"text","conversion_output":true,"text":"treating the baseline value as an outcome, we quantify mean changes in the outcome relative to","text_display":" treating the baseline value as an outcome, we quantify mean changes in the outcome relative to","confidence":1,"confidence_rate":1},{"cnt":[[245,1177],[1794,1177],[1794,1227],[245,1227]],"region":{"top_left_x":244,"top_left_y":1177,"width":1550,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dcf0433caffd4d5a88c9d680474bcee1","type":"text","conversion_output":true,"text":"baseline levels. Differences between the two groups in changes from baseline to 16 and 40","text_display":" baseline levels. Differences between the two groups in changes from baseline to 16 and 40","confidence":1,"confidence_rate":1},{"cnt":[[245,1222],[1828,1222],[1828,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1222,"width":1585,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c27d4a554be4864afafde602b1bc708","type":"text","conversion_output":true,"text":"weeks post-randomization will be compared using Eq. 2 by testing \\(H _{0}: b 4= b 5=0\\) using a Wald","text_display":" weeks post-randomization will be compared using Eq. 2 by testing \\(H _{0}: b 4= b 5=0\\) using a Wald","confidence":0.9829182624816895,"confidence_rate":0.999850191106134},{"cnt":[[245,1268],[1704,1268],[1704,1315],[245,1315]],"region":{"top_left_x":244,"top_left_y":1267,"width":1460,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35d05ab73142446ab128b9c38c7c8f2b","type":"text","conversion_output":true,"text":"chi-square test with type-I error of 0.05 . All treatment effects will be reported with their","text_display":" chi-square test with type-I error of 0.05 . All treatment effects will be reported with their","confidence":0.960956335067749,"confidence_rate":0.9996057578524966},{"cnt":[[245,1311],[874,1311],[874,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1310,"width":631,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7dfe02a6fdd4de983096b544b6e144b","type":"text","conversion_output":true,"text":"respective \\(95 \\%\\) confidence intervals.","text_display":" respective \\(95 \\%\\) confidence intervals.","confidence":0.9970703125,"confidence_rate":0.9999333206905552},{"cnt":[[365,1392],[1149,1392],[1149,1446],[365,1446]],"region":{"top_left_x":365,"top_left_y":1392,"width":785,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f7a3f8d0d4c43ef944ec365f1f2115b","type":"section_header","conversion_output":false,"children_ids":["8b0319d83faf423985911a0795207606"],"text":"","text_display":""},{"cnt":[[374,1399],[1145,1399],[1145,1439],[374,1439]],"region":{"top_left_x":373,"top_left_y":1398,"width":773,"height":42},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b0319d83faf423985911a0795207606","type":"text","conversion_output":true,"parent_id":"3f7a3f8d0d4c43ef944ec365f1f2115b","text":"15.2.3 Cost-Effectiveness of Interventions","text_display":"\n\n\\subsection*{15.2.3 Cost-Effectiveness of Interventions}","confidence":0.9990236759185791,"confidence_rate":0.9999792172160455},{"cnt":[[245,1444],[1878,1444],[1878,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1443,"width":1634,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbd9a0459397431e9f82aed9e3de6038","type":"text","conversion_output":true,"text":"To assess the cost-effectiveness of study interventions, the EEC will conduct analyses of within-","text_display":"\n\nTo assess the cost-effectiveness of study interventions, the EEC will conduct analyses of within","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1871,1487],[1871,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1486,"width":1628,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd4ad565bb6843f4a22d78bc01d48900","type":"text","conversion_output":true,"text":"trial comparisons for the economic endpoints (resource utilization/costs and SF-6D/QALYs) and","text_display":"trial comparisons for the economic endpoints (resource utilization/costs and SF-6D/QALYs) and","confidence":1,"confidence_rate":1},{"cnt":[[245,1532],[1745,1532],[1745,1579],[245,1579]],"region":{"top_left_x":244,"top_left_y":1531,"width":1501,"height":49},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f64d210450742aba0a3fbd6bddc5853","type":"text","conversion_output":true,"text":"will also undertake a model-based analysis that allows the economic value of both study","text_display":" will also undertake a model-based analysis that allows the economic value of both study","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1755,1573],[1755,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1572,"width":1512,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"589a477435fe46e28041b9d3e06c25f5","type":"text","conversion_output":true,"text":"interventions to be assessed relative to usual care. Longitudinal modeling appropriate for","text_display":" interventions to be assessed relative to usual care. Longitudinal modeling appropriate for","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1618],[1846,1618],[1846,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1617,"width":1602,"height":49},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87acddac952d486c85e3a3c2e425f444","type":"text","conversion_output":true,"text":"repeated measures data will be used to make inferences on the overall differences in cost and","text_display":" repeated measures data will be used to make inferences on the overall differences in cost and","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[1755,1663],[1755,1710],[245,1710]],"region":{"top_left_x":244,"top_left_y":1662,"width":1512,"height":49},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5cc15ed5601a45ec9aeb28e6177a5669","type":"text","conversion_output":true,"text":"QALYs associated with the study interventions. The basic statistical analyses of cost and","text_display":" QALYs associated with the study interventions. The basic statistical analyses of cost and","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1687,1706],[1687,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1705,"width":1443,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b8dd1bd1ca24117961ad8cbf62baedd","type":"text","conversion_output":true,"text":"QALYs will be similar to the approach described for other study endpoints, but will be","text_display":" QALYs will be similar to the approach described for other study endpoints, but will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1253,1749],[1253,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1009,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9c9129185ff4a2091d1f342f0d9fdd7","type":"text","conversion_output":true,"text":"undertaken in the EEC in close collaboration with the DCC.","text_display":" undertaken in the EEC in close collaboration with the DCC.","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1803,1835],[1803,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1559,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d68faac760f34d05a1a10894fb13eee5","type":"text","conversion_output":true,"text":"Statistical analyses of SF-6D will produce an estimate of the incremental QALYs associated","text_display":"\n\nStatistical analyses of SF-6D will produce an estimate of the incremental QALYs associated","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1738,1882],[1738,1929],[245,1929]],"region":{"top_left_x":244,"top_left_y":1882,"width":1495,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a83f90a7b4644bdb2b0f8689101d7cc","type":"text","conversion_output":true,"text":"with the PUSH intervention at each time point where SF-36 is measured. The estimated","text_display":" with the PUSH intervention at each time point where SF-36 is measured. The estimated","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1811,1925],[1811,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1925,"width":1568,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30ac176d863848e985626b07cacc4403","type":"text","conversion_output":true,"text":"difference in QALYs attributable to the PUSH intervention will be estimated by taking a time-","text_display":" difference in QALYs attributable to the PUSH intervention will be estimated by taking a time","confidence":1,"confidence_rate":1},{"cnt":[[245,1970],[1781,1970],[1781,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1970,"width":1538,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2e9609c712d453e91f9db36c13ce116","type":"text","conversion_output":true,"text":"weighted average of the time-specific intervention effects. Statistical analyses of cost data,","text_display":"weighted average of the time-specific intervention effects. Statistical analyses of cost data,","confidence":1,"confidence_rate":1},{"cnt":[[245,2015],[1867,2015],[1867,2060],[245,2060]],"region":{"top_left_x":244,"top_left_y":2015,"width":1623,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a056b3df3314fa899559e572e27d4cd","type":"text","conversion_output":true,"text":"which will be adjusted to a constant dollar year (e.g., 2012 US dollars), will produce an estimate","text_display":" which will be adjusted to a constant dollar year (e.g., 2012 US dollars), will produce an estimate","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1515,2058],[1515,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2058,"width":1271,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"581d956d17134eeea201f5ca9c610e22","type":"text","conversion_output":true,"text":"of the incremental costs associated with the PUSH vs.PULSE intervention.","text_display":" of the incremental costs associated with the PUSH vs.PULSE intervention.","confidence":0.99072265625,"confidence_rate":0.9998789599709539},{"cnt":[[245,2144],[1790,2144],[1790,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2144,"width":1546,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41ac12ada8014d8c9d97500eea516fdd","type":"text","conversion_output":true,"text":"The incremental cost-effectiveness ratio (ICER), which is defined as the net change in cost","text_display":"\n\nThe incremental cost-effectiveness ratio (ICER), which is defined as the net change in cost","confidence":1,"confidence_rate":1},{"cnt":[[245,2189],[1830,2189],[1830,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2189,"width":1587,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9aebc4a06c144c86b93ffa6870c8ee9b","type":"text","conversion_output":true,"text":"divided by the net change in effectiveness (QALYs) when interventions are ranked in order of","text_display":" divided by the net change in effectiveness (QALYs) when interventions are ranked in order of","confidence":0.9980475902557373,"confidence_rate":0.9999798525928524},{"cnt":[[245,2234],[1779,2234],[1779,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2234,"width":1535,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5cc2ee090bc4f19846bf27c194892ed","type":"text","conversion_output":true,"text":"increasing cost, is the focus of the economic analysis. When estimated as added cost per","text_display":" increasing cost, is the focus of the economic analysis. When estimated as added cost per","confidence":1,"confidence_rate":1},{"cnt":[[245,2277],[1807,2277],[1807,2325],[245,2325]],"region":{"top_left_x":244,"top_left_y":2277,"width":1563,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95da2682fdb6410a83ae30e4cd52d1d5","type":"text","conversion_output":true,"text":"QALY gained, the ICER allows the value of interventions in hip fracture to be compared with","text_display":" QALY gained, the ICER allows the value of interventions in hip fracture to be compared with","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1807,2320],[1807,2368],[245,2368]],"region":{"top_left_x":244,"top_left_y":2320,"width":1563,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"589bb5b3efb94826bc55af5029f4ad38","type":"text","conversion_output":true,"text":"interventions in other diseases. ICERs will be estimated using both the statistical analysis of","text_display":" interventions in other diseases. ICERs will be estimated using both the statistical analysis of","confidence":1,"confidence_rate":1},{"cnt":[[245,2363],[1794,2363],[1794,2413],[245,2413]],"region":{"top_left_x":244,"top_left_y":2363,"width":1550,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a45082b5c534a01aa03319c430208db","type":"text","conversion_output":true,"text":"cost and QALY data (i.e., trial-based ICER) and a model-based analysis that combines trial","text_display":" cost and QALY data (i.e., trial-based ICER) and a model-based analysis that combines trial","confidence":1,"confidence_rate":1},{"cnt":[[245,2408],[1828,2408],[1828,2456],[245,2456]],"region":{"top_left_x":244,"top_left_y":2408,"width":1585,"height":48},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46f2e3b872564bc29dcfbab934bbb514","type":"text","conversion_output":true,"text":"results with other existing data (i.e., model-based ICER). The trial-based ICER addresses the","text_display":" results with other existing data (i.e., model-based ICER). The trial-based ICER addresses the","confidence":1,"confidence_rate":1},{"cnt":[[245,2454],[1833,2454],[1833,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2453,"width":1589,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"531d7cb61000461a9c2c952bf539846f","type":"text","conversion_output":true,"text":"economic value of the PUSH intervention relative to the PULSE, while the model-based ICER","text_display":" economic value of the PUSH intervention relative to the PULSE, while the model-based ICER","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[662,2587],[662,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":418,"height":38},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6275e812c464d1eb6de54ddb6562f12","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8af47c25a82e400b991d2858352eb750","type":"page_info","conversion_output":false,"text":"62","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-082","page":82,"lines":[{"cnt":[[245,249],[1796,249],[1796,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1553,"height":50},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72d91b9f534e490bbca02b1ec7e5db08","type":"text","conversion_output":true,"text":"estimates the economic value of the study interventions relative to usual care (as described","text_display":"\nestimates the economic value of the study interventions relative to usual care (as described","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[376,296],[376,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":132,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d360684349644b381c10b434af9d3ba","type":"text","conversion_output":true,"text":"below).","text_display":" below).","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1867,382],[1867,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1623,"height":50},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ada23ec627c74e3e837cf9b4172379ea","type":"text","conversion_output":true,"text":"The second objective of the cost-effectiveness analysis is to develop and implement a decision-","text_display":"\n\nThe second objective of the cost-effectiveness analysis is to develop and implement a decision","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,425],[1749,425],[1749,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1505,"height":50},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb09e85e751347c28eae8b4e7eea9178","type":"text","conversion_output":true,"text":"analytic modeling framework that will incorporate within-trial findings regarding costs and","text_display":"analytic modeling framework that will incorporate within-trial findings regarding costs and","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1755,471],[1755,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1512,"height":48},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"efa028f2d20a47ce96d44c8166d549dc","type":"text","conversion_output":true,"text":"QALYs for the purpose of evaluating the cost-effectiveness of the PUSH intervention and","text_display":" QALYs for the purpose of evaluating the cost-effectiveness of the PUSH intervention and","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1785,516],[1785,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1542,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13e9c53ed7024d0aaa35a5dd930f7c69","type":"text","conversion_output":true,"text":"PULSE relative to usual care. Model-based analyses are commonly employed to extend or","text_display":" PULSE relative to usual care. Model-based analyses are commonly employed to extend or","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1828,559],[1828,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1585,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0c3f00cd8044e54a146f15e2039f8e1","type":"text","conversion_output":true,"text":"augment clinical trials because the cost of trials precludes study of all interventions of interest","text_display":" augment clinical trials because the cost of trials precludes study of all interventions of interest","confidence":0.9990234375,"confidence_rate":0.9999906054321309},{"cnt":[[245,602],[1749,602],[1749,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1505,"height":48},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19751637b21f4d0fbfa1d77a66abdd5f","type":"text","conversion_output":true,"text":"and because it is often desirable to consider the value of interventions over a longer time","text_display":" and because it is often desirable to consider the value of interventions over a longer time","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1846,645],[1846,690],[245,690]],"region":{"top_left_x":244,"top_left_y":644,"width":1602,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc73872fea1847b1bf3b9715dfd8fa2e","type":"text","conversion_output":true,"text":"horizon than what is observed in the trial. To make inferences about the economic value of the","text_display":" horizon than what is observed in the trial. To make inferences about the economic value of the","confidence":1,"confidence_rate":1},{"cnt":[[245,690],[1807,690],[1807,737],[245,737]],"region":{"top_left_x":244,"top_left_y":689,"width":1563,"height":48},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5d3b33ff76449128dcc0e11efbc413e","type":"text","conversion_output":true,"text":"study interventions relative to usual care, a Markov state-transition modeling framework that","text_display":" study interventions relative to usual care, a Markov state-transition modeling framework that","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1751,735],[1751,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1507,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"343d86d1847a49819fc502c43b123d02","type":"text","conversion_output":true,"text":"incorporates trial results will be developed and utilized. Estimates of the cost of the study","text_display":" incorporates trial results will be developed and utilized. Estimates of the cost of the study","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1792,778],[1792,823],[245,823]],"region":{"top_left_x":244,"top_left_y":777,"width":1548,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"261ba0b9fb0c4de5a5157a5c0b63b2e3","type":"text","conversion_output":true,"text":"interventions will be derived from time estimates recorded in the field over the course of the","text_display":" interventions will be derived from time estimates recorded in the field over the course of the","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,821],[1785,821],[1785,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1542,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53d3b4e6401348e289565cd78404cc65","type":"text","conversion_output":true,"text":"study. Estimates of the QALY impact of usual care will be derived from existing hip fracture","text_display":" study. Estimates of the QALY impact of usual care will be derived from existing hip fracture","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1833,868],[1833,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1589,"height":47},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0dcad149f4364ae28b79ad1c34e6a82c","type":"text","conversion_output":true,"text":"cohorts (control arms of other trials). Estimates of changes in SF-6D for similar patient groups","text_display":" cohorts (control arms of other trials). Estimates of changes in SF-6D for similar patient groups","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1876,911],[1876,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1632,"height":47},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11376e8569b741b7a0ce21a1a919a6dc","type":"text","conversion_output":true,"text":"are available from the control arms of BHS RCTs. Because these studies have tracked resource","text_display":" are available from the control arms of BHS RCTs. Because these studies have tracked resource","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1828,954],[1828,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1585,"height":49},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"478a1d9f4cec443d85df93e7becb7d42","type":"text","conversion_output":true,"text":"utilization with few questions and follow up measures, extensive sensitivity analyses that vary","text_display":" utilization with few questions and follow up measures, extensive sensitivity analyses that vary","confidence":1,"confidence_rate":1},{"cnt":[[245,999],[1790,999],[1790,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":999,"width":1546,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e193a399fe6497cade317365d33da60","type":"text","conversion_output":true,"text":"the impact of the interventions on resource utilization will be undertaken to characterize the","text_display":" the impact of the interventions on resource utilization will be undertaken to characterize the","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1876,1042],[1876,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1632,"height":49},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4222ec87af9b40a98267208dc1a17f49","type":"text","conversion_output":true,"text":"magnitude of change in costs that would be required to qualitatively affect the conclusions of the","text_display":" magnitude of change in costs that would be required to qualitatively affect the conclusions of the","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,1087],[574,1087],[574,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":330,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f53c0fe50aab445f9ccbc43fb84e9fdd","type":"text","conversion_output":true,"text":"economic analysis.","text_display":" economic analysis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1762,1173],[1762,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1518,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51ce2b19edcf4778a3373cca8c5fcb11","type":"text","conversion_output":true,"text":"The model-based ICER for the study interventions relative to usual care will be compared","text_display":"\n\nThe model-based ICER for the study interventions relative to usual care will be compared","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1854,1216],[1854,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1611,"height":50},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"432048f906294ff0a55db6f589d9670c","type":"text","conversion_output":true,"text":"qualitatively with the costs per additional QALY estimates of other commonly accepted medical","text_display":" qualitatively with the costs per additional QALY estimates of other commonly accepted medical","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1687,1263],[1687,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1263,"width":1443,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cb8b586ffd8499886c8e848c0ee78a8","type":"text","conversion_output":true,"text":"interventions. Uncertainty in the model-based analysis will include estimation of cost-","text_display":" interventions. Uncertainty in the model-based analysis will include estimation of cost","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1727,1306],[1727,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1484,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a814e515dc3440e803b4113ed3e6270","type":"text","conversion_output":true,"text":"effectiveness acceptability curves, which represent the probability that a particular cost-","text_display":"effectiveness acceptability curves, which represent the probability that a particular cost","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1824,1349],[1824,1396],[245,1396]],"region":{"top_left_x":244,"top_left_y":1349,"width":1581,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"678bcac7f58e4272a5cc22d68039e07c","type":"text","conversion_output":true,"text":"effectiveness threshold (e.g., \\$100,000 per QALY gained) is achieved when variability in cost","text_display":"effectiveness threshold (e.g., \\$100,000 per QALY gained) is achieved when variability in cost","confidence":0.89013671875,"confidence_rate":0.9988131516838528},{"cnt":[[245,1392],[1283,1392],[1283,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1039,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bee6fd4bb26d477db1c04394235851f4","type":"text","conversion_output":true,"text":"and QALYs is considered in probabilistic sensitivity analyses.","text_display":" and QALYs is considered in probabilistic sensitivity analyses.","confidence":1,"confidence_rate":1},{"cnt":[[271,1478],[642,1478],[642,1536],[271,1536]],"region":{"top_left_x":270,"top_left_y":1478,"width":373,"height":59},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"735b5dadbef4421f8213dc94b8f738f6","type":"section_header","conversion_output":false,"children_ids":["b0d870d464cb40ef9906e0d7b1e74588"],"text":"","text_display":""},{"cnt":[[277,1482],[638,1482],[638,1532],[277,1532]],"region":{"top_left_x":277,"top_left_y":1482,"width":362,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0d870d464cb40ef9906e0d7b1e74588","type":"text","conversion_output":true,"parent_id":"735b5dadbef4421f8213dc94b8f738f6","text":"15.3 Missing Data","text_display":"\n\n\\subsection*{15.3 Missing Data}","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1807,1530],[1807,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":1563,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d0936b764844b5ab8df66719de6546f","type":"text","conversion_output":true,"text":"By design, there will be no missing data at baseline because only participants with complete","text_display":"\n\nBy design, there will be no missing data at baseline because only participants with complete","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1828,1573],[1828,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1572,"width":1585,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2217717d8dc64feab182c9449dfd1bf7","type":"text","conversion_output":true,"text":"baseline data will be randomized. At follow-up, scores for scales that have published rules for","text_display":" baseline data will be randomized. At follow-up, scores for scales that have published rules for","confidence":1,"confidence_rate":1},{"cnt":[[245,1618],[1803,1618],[1803,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1617,"width":1559,"height":49},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"952cdf2ae6ab42b8b7e181ebc89bbb62","type":"text","conversion_output":true,"text":"handling missing scale items (e.g., the CES-D and the SF-36) will be calculated using those","text_display":" handling missing scale items (e.g., the CES-D and the SF-36) will be calculated using those","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[1828,1663],[1828,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1662,"width":1585,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04eb137cbfa14bf79fa7db96e0247ebb","type":"text","conversion_output":true,"text":"rules. All other scales will be considered missing if any part of the scale is missing. To correct","text_display":" rules. All other scales will be considered missing if any part of the scale is missing. To correct","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1837,1706],[1837,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1705,"width":1593,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acd0d40f59ce45c88ed89e3dc0cdc587","type":"text","conversion_output":true,"text":"for potential selection bias from missing data, we will perform a weighted estimating equations","text_display":" for potential selection bias from missing data, we will perform a weighted estimating equations","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1747],[1841,1747],[1841,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1746,"width":1598,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c092ccbac8fb434a8dbef97cebce63e3","type":"text","conversion_output":true,"text":"(WEE) analysis. \\({ }^{209}\\) This method involves two steps. First the probability of being observed (not","text_display":" (WEE) analysis. \\({ }^{209}\\) This method involves two steps. First the probability of being observed (not","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1742,1792],[1742,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1791,"width":1499,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fd1f9270fa949e1b5f572f6f95c11d6","type":"text","conversion_output":true,"text":"missing) is calculated as a function of predictors of missingness. Next the relationship of","text_display":" missing) is calculated as a function of predictors of missingness. Next the relationship of","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1815,1835],[1815,1882],[245,1882]],"region":{"top_left_x":244,"top_left_y":1834,"width":1572,"height":49},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b098247231a1429f8c77f879baa3bf07","type":"text","conversion_output":true,"text":"treatment group to outcome is assessed using the inverse probability of being observed as a","text_display":" treatment group to outcome is assessed using the inverse probability of being observed as a","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1858,1882],[1858,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1882,"width":1615,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59407fabe84a42428438389d3df1cbe6","type":"text","conversion_output":true,"text":"weight in the GEE model. WEEs are advantageous because a) they are consistent with the ITT","text_display":" weight in the GEE model. WEEs are advantageous because a) they are consistent with the ITT","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1925],[1734,1925],[1734,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1490,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb6a95e2f7c84edeaa72dfb2d2935e11","type":"text","conversion_output":true,"text":"principle because participants with missing data are included in the analysis through the","text_display":" principle because participants with missing data are included in the analysis through the","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1732,1968],[1732,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1967,"width":1488,"height":47},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0ce05f762614639a1b3b71dd6c95eed","type":"text","conversion_output":true,"text":"estimated weight, and b) unlike other methods for addressing missing data, they can be","text_display":" estimated weight, and b) unlike other methods for addressing missing data, they can be","confidence":1,"confidence_rate":1},{"cnt":[[245,2013],[1867,2013],[1867,2060],[245,2060]],"region":{"top_left_x":244,"top_left_y":2013,"width":1623,"height":48},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ddc05bc6c87c48e0be0394a3760c420a","type":"text","conversion_output":true,"text":"performed in conjunction with marginal structural modeling by multiplying both weights together.","text_display":" performed in conjunction with marginal structural modeling by multiplying both weights together.","confidence":1,"confidence_rate":1},{"cnt":[[271,2093],[672,2093],[672,2151],[271,2151]],"region":{"top_left_x":270,"top_left_y":2092,"width":403,"height":59},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f63da8604e854ab0ab73aa49073d7cab","type":"section_header","conversion_output":false,"children_ids":["557a7134548d4a86adbab9451f7531b3"],"text":"","text_display":""},{"cnt":[[277,2101],[668,2101],[668,2146],[277,2146]],"region":{"top_left_x":277,"top_left_y":2101,"width":392,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"557a7134548d4a86adbab9451f7531b3","type":"text","conversion_output":true,"parent_id":"f63da8604e854ab0ab73aa49073d7cab","text":"15.4 Nonadherence","text_display":"\n\n\\subsection*{15.4 Nonadherence}","confidence":1,"confidence_rate":1},{"cnt":[[245,2148],[1815,2148],[1815,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2148,"width":1572,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9eb931a3ae8540c5a325b7c97ce758ab","type":"text","conversion_output":true,"text":"In the presence of nonadherence, ITT analyses have the benefit of conservatively estimating","text_display":"\n\nIn the presence of nonadherence, ITT analyses have the benefit of conservatively estimating","confidence":0.99853515625,"confidence_rate":0.9999847301407262},{"cnt":[[245,2191],[1824,2191],[1824,2239],[245,2239]],"region":{"top_left_x":244,"top_left_y":2191,"width":1581,"height":48},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e64c611a555545da9ba403739603c24d","type":"text","conversion_output":true,"text":"effects. However, ITT analyses may miss true effects because their results are biased toward","text_display":" effects. However, ITT analyses may miss true effects because their results are biased toward","confidence":1,"confidence_rate":1},{"cnt":[[245,2234],[1871,2234],[1871,2282],[245,2282]],"region":{"top_left_x":244,"top_left_y":2234,"width":1628,"height":48},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1676773b50b64c60a5316abb098d5884","type":"text","conversion_output":true,"text":"the null. To address this issue, we will examine adherence (defined as proportion of intervention","text_display":" the null. To address this issue, we will examine adherence (defined as proportion of intervention","confidence":1,"confidence_rate":1},{"cnt":[[245,2282],[1846,2282],[1846,2327],[245,2327]],"region":{"top_left_x":244,"top_left_y":2281,"width":1602,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73dd0bab021943d4bdca7de58e5ce4f7","type":"text","conversion_output":true,"text":"visits completed) in both intervention groups. If adherence is less than \\(80 \\%\\) in either group, we","text_display":" visits completed) in both intervention groups. If adherence is less than \\(80 \\%\\) in either group, we","confidence":0.9975600242614746,"confidence_rate":0.9999765103015572},{"cnt":[[245,2325],[1652,2325],[1652,2370],[245,2370]],"region":{"top_left_x":244,"top_left_y":2324,"width":1409,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"356c4561bd464bcca2c91b6e12ec8005","type":"text","conversion_output":true,"text":"will perform a secondary analysis adapting marginal structural modeling to address","text_display":" will perform a secondary analysis adapting marginal structural modeling to address","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1871,2368],[1871,2413],[245,2413]],"region":{"top_left_x":244,"top_left_y":2367,"width":1628,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aca8e9c693b3473bac4de6bac142c583","type":"text","conversion_output":true,"text":"noncompliance. In this case, the weight will be the inverse probability of treatment received as a","text_display":" noncompliance. In this case, the weight will be the inverse probability of treatment received as a","confidence":1,"confidence_rate":1},{"cnt":[[245,2411],[1876,2411],[1876,2458],[245,2458]],"region":{"top_left_x":244,"top_left_y":2410,"width":1632,"height":48},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be6065e9cefe48788d9edbe0469d245a","type":"text","conversion_output":true,"text":"function of treatment assignment and factors that may affect treatment compliance. This method","text_display":" function of treatment assignment and factors that may affect treatment compliance. This method","confidence":1,"confidence_rate":1},{"cnt":[[245,2454],[1762,2454],[1762,2503],[245,2503]],"region":{"top_left_x":244,"top_left_y":2453,"width":1518,"height":50},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcbd971b9d954a98addc6f2a15a0d3f3","type":"text","conversion_output":true,"text":"has the benefit of accounting for intermediary factors that may impact compliance without","text_display":" has the benefit of accounting for intermediary factors that may impact compliance without","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c4ed7348d644aa19d294d815eda41c8","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1833,2587],[1886,2587],[1886,2628],[1833,2628]],"region":{"top_left_x":1832,"top_left_y":2586,"width":55,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6d9e3dbf2234c819469eb6475228a57","type":"page_info","conversion_output":false,"text":"63","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-083","page":83,"lines":[{"cnt":[[245,251],[1807,251],[1807,299],[245,299]],"region":{"top_left_x":244,"top_left_y":251,"width":1563,"height":48},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16279d99ea4d44b5bee931c2c64c3472","type":"text","conversion_output":true,"text":"distorting the randomization by conditioning on these factors (i.e., a marginal analysis rather","text_display":"\ndistorting the randomization by conditioning on these factors (i.e., a marginal analysis rather","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1768,296],[1768,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1525,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6a60956f5d34834ad53522ee988b13e","type":"text","conversion_output":true,"text":"than a conditional analysis). Precedents for this approach are available in the literature by","text_display":" than a conditional analysis). Precedents for this approach are available in the literature by","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,337],[397,337],[397,380],[245,380]],"region":{"top_left_x":244,"top_left_y":337,"width":154,"height":44},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d24638d6ef4343cb8786ffbe242f703d","type":"text","conversion_output":true,"text":"Cook. \\({ }^{210}\\)","text_display":" Cook. \\({ }^{210}\\)","confidence":1,"confidence_rate":1},{"cnt":[[271,421],[715,421],[715,483],[271,483]],"region":{"top_left_x":270,"top_left_y":421,"width":446,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"749f51e70e0b4b62906b9b53f722c3fa","type":"section_header","conversion_output":false,"children_ids":["9204cb9b828846b58fd58a82f2dec441"],"text":"","text_display":""},{"cnt":[[277,425],[711,425],[711,477],[277,477]],"region":{"top_left_x":277,"top_left_y":425,"width":435,"height":52},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9204cb9b828846b58fd58a82f2dec441","type":"text","conversion_output":true,"parent_id":"749f51e70e0b4b62906b9b53f722c3fa","text":"15.5 Interim Analyses","text_display":"\n\n\\subsection*{15.5 Interim Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[245,475],[1878,475],[1878,522],[245,522]],"region":{"top_left_x":244,"top_left_y":474,"width":1634,"height":49},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87f4106ad4b14bf0b41c38ca8f938321","type":"text","conversion_output":true,"text":"Interim analyses will be conducted by an alpha and lower bound spending design. At the time of","text_display":"\n\nInterim analyses will be conducted by an alpha and lower bound spending design. At the time of","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[245,520],[1876,520],[1876,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":1632,"height":47},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a757f0d80c348859cb3dcd04c17d5c8","type":"text","conversion_output":true,"text":"this update, we have already performed an interim analysis based on the first \\(28.6 \\%\\) of the data.","text_display":" this update, we have already performed an interim analysis based on the first \\(28.6 \\%\\) of the data.","confidence":0.97119140625,"confidence_rate":0.9997189653889206},{"cnt":[[245,563],[1858,563],[1858,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1615,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31ab9e52bdce460dab392cf00514a2ba","type":"text","conversion_output":true,"text":"We plan to perform three additional interim analyses (based on the first \\(40 \\%, 60 \\%\\), and \\(80 \\%\\) of","text_display":" We plan to perform three additional interim analyses (based on the first \\(40 \\%, 60 \\%\\), and \\(80 \\%\\) of","confidence":0.9858850862709019,"confidence_rate":0.9998633220668988},{"cnt":[[245,606],[1747,606],[1747,655],[245,655]],"region":{"top_left_x":244,"top_left_y":605,"width":1503,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ec0c42ec96240cfb68ea1c4f0ee39c8","type":"text","conversion_output":true,"text":"data available), where the boundary values for early stopping will be evaluated using the","text_display":" data available), where the boundary values for early stopping will be evaluated using the","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1820,649],[1820,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":1576,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2de6ebeaf844ac991301a90b3464175","type":"text","conversion_output":true,"text":"Hwang-Shih-Decani spending function approximation to the O'Brien-Fleming alpha-spending","text_display":" Hwang-Shih-Decani spending function approximation to the O'Brien-Fleming alpha-spending","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,694],[1768,694],[1768,741],[245,741]],"region":{"top_left_x":244,"top_left_y":693,"width":1525,"height":49},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2dc5a3f0223d469b912d682739da01d8","type":"text","conversion_output":true,"text":"function [gamma=-4 for lower-bound alpha spending (inefficacy/harm), and gamma=-4 for","text_display":" function [gamma=-4 for lower-bound alpha spending (inefficacy/harm), and gamma=-4 for","confidence":0.998535871389322,"confidence_rate":0.9999837201159151},{"cnt":[[245,735],[1867,735],[1867,786],[245,786]],"region":{"top_left_x":244,"top_left_y":734,"width":1623,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80e01744a9434966b9c57b7c761c58d7","type":"text","conversion_output":true,"text":"upper-bound alpha spending (efficacy)]. \\({ }^{211,212}\\) The upper and lower bounds will be computed for","text_display":" upper-bound alpha spending (efficacy)]. \\({ }^{211,212}\\) The upper and lower bounds will be computed for","confidence":0.99560546875,"confidence_rate":0.9999599624780234},{"cnt":[[245,782],[1820,782],[1820,829],[245,829]],"region":{"top_left_x":244,"top_left_y":782,"width":1576,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c817b4d417941779c9134c7daa49525","type":"text","conversion_output":true,"text":"a test of efficacy with one-sided nominal alpha \\(=0.025\\). For example, when testing for efficacy","text_display":" a test of efficacy with one-sided nominal alpha \\(=0.025\\). For example, when testing for efficacy","confidence":0.9622477875800541,"confidence_rate":0.9996264456525314},{"cnt":[[245,825],[1846,825],[1846,874],[245,874]],"region":{"top_left_x":244,"top_left_y":824,"width":1602,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"051a52bdb79f4572a2d758126e3dd37d","type":"text","conversion_output":true,"text":"(delta \\(>0\\) ) at the first interim analysis, \\(Z >3.09\\) would denote efficacy, and \\(Z <-1.76\\) would denote","text_display":" (delta \\(>0\\) ) at the first interim analysis, \\(Z >3.09\\) would denote efficacy, and \\(Z <-1.76\\) would denote","confidence":0.9446478350818251,"confidence_rate":0.9995134254052938},{"cnt":[[245,870],[1850,870],[1850,917],[245,917]],"region":{"top_left_x":244,"top_left_y":870,"width":1606,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af9f87fa4e024b69bdd5b9e96ab744a4","type":"text","conversion_output":true,"text":"inefficacy/harm. Table 4 shows the anticipated proportion of the sample accrued at each of the","text_display":" inefficacy/harm. Table 4 shows the anticipated proportion of the sample accrued at each of the","confidence":1,"confidence_rate":1},{"cnt":[[245,915],[1880,915],[1880,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1636,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6495e4559e984fb19cbfc7d2f4582342","type":"text","conversion_output":true,"text":"remaining interim analyses along with the corresponding critical values for declaring significance","text_display":" remaining interim analyses along with the corresponding critical values for declaring significance","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[1742,958],[1742,1005],[245,1005]],"region":{"top_left_x":244,"top_left_y":958,"width":1499,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20abd136c2f44184a4146ba948ec2733","type":"text","conversion_output":true,"text":"(or lack thereof) at each time point. The critical values are subject to change if the actual","text_display":" (or lack thereof) at each time point. 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Assuming normal","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1807,471],[1807,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1563,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb01a111daca40dd913b8b8b0452dfb6","type":"text","conversion_output":true,"text":"distributions for the SMWT, and with \\(16 \\%\\) surpassing the 300 meter threshold in the PULSE","text_display":" distributions for the SMWT, and with \\(16 \\%\\) surpassing the 300 meter threshold in the PULSE","confidence":0.99755859375,"confidence_rate":0.9999753094831817},{"cnt":[[245,516],[1768,516],[1768,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1525,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfe14407972047279a218a62b02654c5","type":"text","conversion_output":true,"text":"group at 16 weeks, a 0.6 SD effect size projects to a 19 percentage point difference in the","text_display":" group at 16 weeks, a 0.6 SD effect size projects to a 19 percentage point difference in the","confidence":0.9975600242614746,"confidence_rate":0.999977168883715},{"cnt":[[245,559],[1738,559],[1738,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":1495,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf392174e39740338d74c584ffd88f6a","type":"text","conversion_output":true,"text":"proportion of community ambulators between the PUSH group and the PULSE group. A","text_display":" proportion of community ambulators between the PUSH group and the PULSE group. A","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1878,602],[1878,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1634,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce3f1f0ce794464f8b65692b8dfc5701","type":"text","conversion_output":true,"text":"difference of 20 percentage points or more in the proportion of participants achieving community","text_display":" difference of 20 percentage points or more in the proportion of participants achieving community","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,645],[1523,645],[1523,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1280,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"904b93bf48614b9f82fe86825054e7ad","type":"text","conversion_output":true,"text":"ambulation is thus considered an achievable and clinically meaningful goal.","text_display":" ambulation is thus considered an achievable and clinically meaningful goal.","confidence":1,"confidence_rate":1},{"cnt":[[245,733],[1876,733],[1876,782],[245,782]],"region":{"top_left_x":244,"top_left_y":732,"width":1632,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7232fcca1c7495ca0222b2c2b78bddc","type":"text","conversion_output":true,"text":"Using a group sequential design with four interim analyses (see Section 15.5), and assuming an","text_display":"\n\nUsing a group sequential design with four interim analyses (see Section 15.5), and assuming an","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1858,778],[1858,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1615,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4939f658d884954b00a87022b1f13db","type":"text","conversion_output":true,"text":"overall loss to follow-up of \\(6.8 \\%\\) and treatment non-compliance of \\(12.2 \\%\\), a total sample of 210","text_display":" overall loss to follow-up of \\(6.8 \\%\\) and treatment non-compliance of \\(12.2 \\%\\), a total sample of 210","confidence":0.9506255933083594,"confidence_rate":0.9995178782404995},{"cnt":[[245,821],[1742,821],[1742,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1499,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2068b859e864094ae1125ba57ba82fa","type":"text","conversion_output":true,"text":"enrolled patients ( 105 patients per group) is sufficient to achieve over \\(80 \\%\\) power for the","text_display":" enrolled patients ( 105 patients per group) is sufficient to achieve over \\(80 \\%\\) power for the","confidence":0.9385063648223877,"confidence_rate":0.9993779813665084},{"cnt":[[245,864],[1843,864],[1843,913],[245,913]],"region":{"top_left_x":244,"top_left_y":863,"width":1600,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfe110aaf1a4457896016b8c9b42adb7","type":"text","conversion_output":true,"text":"detection of a 20 percentage point difference between the groups, with \\(16 \\%\\) achieving the 300","text_display":" detection of a 20 percentage point difference between the groups, with \\(16 \\%\\) achieving the 300","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,911],[1824,911],[1824,958],[245,958]],"region":{"top_left_x":244,"top_left_y":910,"width":1581,"height":49},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce7810283efd480fb3e63aabcfedb2b8","type":"text","conversion_output":true,"text":"m threshold of the SMWT in the PULSE group vs \\(36 \\%\\) in the PUSH group, using a one-sided","text_display":" m threshold of the SMWT in the PULSE group vs \\(36 \\%\\) in the PUSH group, using a one-sided","confidence":0.99853515625,"confidence_rate":0.9999847301407262},{"cnt":[[245,954],[1854,954],[1854,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1611,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d234c936d6247a9a326ee1203da803a","type":"text","conversion_output":true,"text":"0.025 significance level. The power specified is for the detection of a time-specific difference at","text_display":" 0.025 significance level. The power specified is for the detection of a time-specific difference at","confidence":1,"confidence_rate":1},{"cnt":[[245,999],[1869,999],[1869,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":999,"width":1626,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4005c9ea0cda4290ad557168caed6731","type":"text","conversion_output":true,"text":"the 16 -week follow-up. This calculation accounts for the sample size inflation of \\(2.4 \\%\\) needed to","text_display":" the 16 -week follow-up. This calculation accounts for the sample size inflation of \\(2.4 \\%\\) needed to","confidence":0.77978515625,"confidence_rate":0.9976995312734868},{"cnt":[[245,1040],[1755,1040],[1755,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1039,"width":1512,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b558a1e902534d438f0be2dd68765dbb","type":"text","conversion_output":true,"text":"account for the group sequential design \\({ }^{211,212}\\) and for the impact of noncompliance on the","text_display":" account for the group sequential design \\({ }^{211,212}\\) and for the impact of noncompliance on the","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1785,1087],[1785,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1542,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22d6d65b219448998c7655d79e26307c","type":"text","conversion_output":true,"text":"variance of treatment differences under the assumption that non-compliers assigned to the","text_display":" variance of treatment differences under the assumption that non-compliers assigned to the","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1880,1130],[1880,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1636,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d6a34cb26114721a90b1f221ef1d32e","type":"text","conversion_output":true,"text":"PUSH group have an equal 16-week proportion achieving community ambulation as participants","text_display":" PUSH group have an equal 16-week proportion achieving community ambulation as participants","confidence":0.58154296875,"confidence_rate":0.9943102439365975},{"cnt":[[245,1171],[857,1171],[857,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1170,"width":614,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29f4d5f5020143869a9fa8abaeda5816","type":"text","conversion_output":true,"text":"assigned to the PULSE group. \\({ }^{214,215}\\)","text_display":" assigned to the PULSE group. \\({ }^{214,215}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1261],[1721,1261],[1721,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1261,"width":1477,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"411cb3b3eb7440e09146d0dc5250883f","type":"text","conversion_output":true,"text":"Table 5 shows the power to detect various between-group differences in proportions of","text_display":"\n\nTable 5 shows the power to detect various between-group differences in proportions of","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1755,1306],[1755,1354],[245,1354]],"region":{"top_left_x":244,"top_left_y":1306,"width":1512,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"427acbee222444fb9477f19068606770","type":"text","conversion_output":true,"text":"community ambulators using a one-tailed test of the difference in proportions at the \\(2.5 \\%\\)","text_display":" community ambulators using a one-tailed test of the difference in proportions at the \\(2.5 \\%\\)","confidence":0.98388671875,"confidence_rate":0.9998253430846327},{"cnt":[[245,1349],[1704,1349],[1704,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1349,"width":1460,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af590af4b36f4559a45e44fb43794bf6","type":"text","conversion_output":true,"text":"significance level. The table indicates that the study has adequate power for detecting","text_display":" significance level. The table indicates that the study has adequate power for detecting","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[965,1392],[965,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1392,"width":721,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fdb3ea4fd504599ae1a830b03471189","type":"text","conversion_output":true,"text":"differences down to 20 percentage points.","text_display":" differences down to 20 percentage points.","confidence":1,"confidence_rate":1},{"cnt":[[245,1527],[245,1478],[1165,1480],[1164,1530]],"region":{"top_left_x":244,"top_left_y":1478,"width":921,"height":52},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"286e0eeab6eb4f5da8b3ac233ee4c4ab","type":"figure_label","conversion_output":false,"text":"Table 5. Power to Detect Difference in Proportions","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999911200303706},{"cnt":[[225,1938],[226,1517],[1442,1519],[1442,1940]],"region":{"top_left_x":224,"top_left_y":1517,"width":1219,"height":424},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3906f09eb6e49d0a2712da91f864621","type":"table","conversion_output":true,"selected_labels":["286e0eeab6eb4f5da8b3ac233ee4c4ab"],"text":"\\begin{tabular}{|l|c|}\n\\hline \\begin{tabular}{l} \nTrue Difference in Proportion Achieving \\\\\nCommunity Ambulation at 16 Weeks\n\\end{tabular} & Power (\\%) \\\\\n\\hline 23 percentage points & 89 \\\\\n\\hline 22 percentage points & 87 \\\\\n\\hline 21 percentage points & 84 \\\\\n\\hline 20 percentage points & 80 \\\\\n\\hline 19 percentage points & 76 \\\\\n\\hline 18 percentage points & 72 \\\\\n\\hline 17 percentage points & 68 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 5. Power to Detect Difference in Proportions}\n\\begin{tabular}{|l|c|}\n\\hline \\begin{tabular}{l} \nTrue Difference in Proportion Achieving \\\\\nCommunity Ambulation at 16 Weeks\n\\end{tabular} & Power (\\%) \\\\\n\\hline 23 percentage points & 89 \\\\\n\\hline 22 percentage points & 87 \\\\\n\\hline 21 percentage points & 84 \\\\\n\\hline 20 percentage points & 80 \\\\\n\\hline 19 percentage points & 76 \\\\\n\\hline 18 percentage points & 72 \\\\\n\\hline 17 percentage points & 68 \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.7450809478759766,"confidence_rate":0.9991874507069505},{"cnt":[[370,1977],[806,1977],[806,2030],[370,2030]],"region":{"top_left_x":369,"top_left_y":1976,"width":437,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68e87ab27f184c71bf2d6d445284a0e9","type":"section_header","conversion_output":false,"children_ids":["12047f052b0141be8d0be156eb3dc5b9"],"text":"","text_display":""},{"cnt":[[374,1981],[801,1981],[801,2026],[374,2026]],"region":{"top_left_x":373,"top_left_y":1980,"width":429,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12047f052b0141be8d0be156eb3dc5b9","type":"text","conversion_output":true,"parent_id":"68e87ab27f184c71bf2d6d445284a0e9","text":"15.6.2 Secondary Aims","text_display":"\n\n\\subsection*{15.6.2 Secondary Aims}","confidence":1,"confidence_rate":1},{"cnt":[[245,2024],[1811,2024],[1811,2071],[245,2071]],"region":{"top_left_x":244,"top_left_y":2023,"width":1568,"height":49},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f773195873ab4abf994d7cfa4cddfa64","type":"text","conversion_output":true,"text":"Delayed and Sustained Effects. Follow-up will end at 16 weeks post-randomization for those","text_display":"\n\nDelayed and Sustained Effects. Follow-up will end at 16 weeks post-randomization for those","confidence":0.986328125,"confidence_rate":0.9998595384802946},{"cnt":[[245,2067],[1854,2067],[1854,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2066,"width":1611,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c4742d8a8a5455cae56e0173e6f57a7","type":"text","conversion_output":true,"text":"consented under version 10.0 of the protocol. We estimate that there will be approximately 150","text_display":" consented under version 10.0 of the protocol. We estimate that there will be approximately 150","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,2110],[1833,2110],[1833,2159],[245,2159]],"region":{"top_left_x":244,"top_left_y":2109,"width":1589,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc9df171ca80439d94f29d8587915d1b","type":"text","conversion_output":true,"text":"participants (not the full 210 ) for whom the 40 -week measure of community ambulation will be","text_display":" participants (not the full 210 ) for whom the 40 -week measure of community ambulation will be","confidence":0.987830612808466,"confidence_rate":0.9998833968895435},{"cnt":[[245,2157],[1742,2157],[1742,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2157,"width":1499,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8aa5896e55c344ccaa86fc62bb077760","type":"text","conversion_output":true,"text":"available. In addition, based on our experience to date, we estimate that the community","text_display":" available. In addition, based on our experience to date, we estimate that the community","confidence":1,"confidence_rate":1},{"cnt":[[245,2200],[1674,2200],[1674,2247],[245,2247]],"region":{"top_left_x":244,"top_left_y":2200,"width":1430,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a616b4c16274f1090c7c2656d0d3585","type":"text","conversion_output":true,"text":"ambulation outcome will be indeterminate for \\(10 \\%\\) of the participants at the 40 -week","text_display":" ambulation outcome will be indeterminate for \\(10 \\%\\) of the participants at the 40 -week","confidence":0.9902389049530029,"confidence_rate":0.9998967522058763},{"cnt":[[245,2243],[1740,2243],[1740,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2242,"width":1497,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8dfb2ad136d345c5b49599048f131194","type":"text","conversion_output":true,"text":"assessment. If we assume a sample size of 150 then there is \\(64 \\%\\) power for detecting a","text_display":" assessment. If we assume a sample size of 150 then there is \\(64 \\%\\) power for detecting a","confidence":1,"confidence_rate":1},{"cnt":[[245,2288],[1485,2288],[1485,2335],[245,2335]],"region":{"top_left_x":244,"top_left_y":2288,"width":1241,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7eee5d41a4c140c0b5ea132855118df9","type":"text","conversion_output":true,"text":"difference of 20 percentage points at alpha \\(=0.05\\) using a two-tailed test.","text_display":" difference of 20 percentage points at alpha \\(=0.05\\) using a two-tailed test.","confidence":1,"confidence_rate":1},{"cnt":[[245,2376],[1850,2376],[1850,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2376,"width":1606,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c83adc967ad7451a9e812295d3199d3c","type":"text","conversion_output":true,"text":"Effect on Secondary and Tertiary Outcomes. Using a two-sided test with alpha \\(=0.05\\), a sample","text_display":"\n\nEffect on Secondary and Tertiary Outcomes. Using a two-sided test with alpha \\(=0.05\\), a sample","confidence":0.8701171875,"confidence_rate":0.9986234495226253},{"cnt":[[245,2419],[1796,2419],[1796,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2419,"width":1553,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de3bd15310af48b1bf9eb025571bee76","type":"text","conversion_output":true,"text":"of 210 patients with \\(6.8 \\%\\) loss to follow-up and \\(12.2 \\%\\) treatment noncompliance will provide","text_display":" of 210 patients with \\(6.8 \\%\\) loss to follow-up and \\(12.2 \\%\\) treatment noncompliance will provide","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2625],[245,2625]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":40},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2207df0e634c4d849632403b079ff317","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c86fe84facc3458f84a483e5657f92fe","type":"page_info","conversion_output":false,"text":"65","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-085","page":85,"lines":[{"cnt":[[245,249],[1807,249],[1807,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1563,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7d2b12b270c4464a56de9a2aa9ae37a","type":"text","conversion_output":true,"text":"\\(80 \\%\\) power to detect effect sizes of 0.46 SD at 16 weeks, which are considered moderate in","text_display":"\n\\(80 \\%\\) power to detect effect sizes of 0.46 SD at 16 weeks, which are considered moderate in","confidence":0.5418636449963155,"confidence_rate":0.9938298123881474},{"cnt":[[245,296],[1876,296],[1876,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1632,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76fc492cb9c04569b0e58f548e2e621d","type":"text","conversion_output":true,"text":"size, under the assumption that noncompliers assigned to the PUSH group have an equal mean","text_display":" size, under the assumption that noncompliers assigned to the PUSH group have an equal mean","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1846,339],[1846,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1602,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"962cd5092f064ff6a0a5b7d5c7883e2d","type":"text","conversion_output":true,"text":"and standard deviation as patients assigned to the PULSE group. Collection of some outcome","text_display":" and standard deviation as patients assigned to the PULSE group. Collection of some outcome","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1807,382],[1807,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1563,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cff8dce5daf643a4b82aa6d45ccb43c3","type":"text","conversion_output":true,"text":"measures will end after implementation of protocol version 11.0 (see Section 11:). For these","text_display":" measures will end after implementation of protocol version 11.0 (see Section 11:). For these","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1811,425],[1811,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1568,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a2389ce749b42ecad91a457bafd5b90","type":"text","conversion_output":true,"text":"measures, we estimate that there will be approximately 160 participants (not the full 210 ) for","text_display":" measures, we estimate that there will be approximately 160 participants (not the full 210 ) for","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,471],[1824,471],[1824,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1581,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d72ab1be53714873a0171dd13a86dffe","type":"text","conversion_output":true,"text":"whom the 16 -week measure will be available. Under the same assumptions, a sample of 160","text_display":" whom the 16 -week measure will be available. Under the same assumptions, a sample of 160","confidence":0.980478048324585,"confidence_rate":0.9997924949864327},{"cnt":[[245,516],[1240,516],[1240,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":996,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb95afb7ec43457aa383f388a8d89888","type":"text","conversion_output":true,"text":"will provide \\(80 \\%\\) power to detect an effect size of 0.53 SD.","text_display":" will provide \\(80 \\%\\) power to detect an effect size of 0.53 SD.","confidence":0.8330383883231058,"confidence_rate":0.9973937514147593},{"cnt":[[245,602],[1833,602],[1833,651],[245,651]],"region":{"top_left_x":244,"top_left_y":601,"width":1589,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35184bd932694a878edd69a6822cfa3a","type":"text","conversion_output":true,"text":"Economic Evaluation. Follow-up will end at 16 weeks post-randomization for those consented","text_display":"\n\nEconomic Evaluation. Follow-up will end at 16 weeks post-randomization for those consented","confidence":0.99755859375,"confidence_rate":0.9999750575422747},{"cnt":[[245,645],[1876,645],[1876,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1632,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bee73475b56241bb80e5f60821b30b4c","type":"text","conversion_output":true,"text":"under version 10.0 of the protocol. We estimate that there will be approximately 150 participants","text_display":" under version 10.0 of the protocol. We estimate that there will be approximately 150 participants","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,692],[1852,692],[1852,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1608,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e93901ab3344fee866250e7d6a02338","type":"text","conversion_output":true,"text":"for whom the full 40-week follow-up will be available. Assuming a mean SF-6D score of 0.62 in","text_display":" for whom the full 40-week follow-up will be available. Assuming a mean SF-6D score of 0.62 in","confidence":0.61865234375,"confidence_rate":0.9952567127516744},{"cnt":[[245,735],[1850,735],[1850,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1606,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1bc3455850b4f6d86043ca0e36fda0b","type":"text","conversion_output":true,"text":"the PULSE group and between-subject standard deviation of 0.10 (based on unpublished data","text_display":" the PULSE group and between-subject standard deviation of 0.10 (based on unpublished data","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1796,778],[1796,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1553,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3843b9c5ca4c4a1f8182115b8ae8f869","type":"text","conversion_output":true,"text":"from the fourth BHS cohort study), and assuming that non-compliers assigned to the PUSH","text_display":" from the fourth BHS cohort study), and assuming that non-compliers assigned to the PUSH","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1858,821],[1858,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1615,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f15f8b05c66c4f0f9621d68819db0028","type":"text","conversion_output":true,"text":"group have an equal mean and standard deviation as patients assigned to the PULSE group, a","text_display":" group have an equal mean and standard deviation as patients assigned to the PULSE group, a","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1783,868],[1783,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1540,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ea58fa6c0d64b14ad71c352d9cd0f81","type":"text","conversion_output":true,"text":"sample size of 75 per group will allow us to detect a between-group difference in means of","text_display":" sample size of 75 per group will allow us to detect a between-group difference in means of","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,911],[1270,911],[1270,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1026,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d55a06d674124d3988638c5dea69b844","type":"text","conversion_output":true,"text":"0.055 with \\(80 \\%\\) power and using a two-sided 0.05 -level test.","text_display":" 0.055 with \\(80 \\%\\) power and using a two-sided 0.05 -level test.","confidence":0.9990236759185791,"confidence_rate":0.9999860457974148},{"cnt":[[245,997],[1807,997],[1807,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":996,"width":1563,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bf8a588aebc4e37bb619166db70e4aa","type":"text","conversion_output":true,"text":"Costs will be used in conjunction with information on patient quality of life to make treatment","text_display":"\n\nCosts will be used in conjunction with information on patient quality of life to make treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1869,1042],[1869,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1626,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7978a3d004cf412e98400bcf690982fa","type":"text","conversion_output":true,"text":"outcome comparisons in terms of cost per QALY associated with treatment effects. The primary","text_display":" outcome comparisons in terms of cost per QALY associated with treatment effects. The primary","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1833,1087],[1833,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1589,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7aadffedbff54765a678c14779a6376d","type":"text","conversion_output":true,"text":"interest in the economic evaluation is to assess the impact of variability in cost and QALYs on","text_display":" interest in the economic evaluation is to assess the impact of variability in cost and QALYs on","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1878,1130],[1878,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1634,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f9ebc3a101f4eb1a00aa23f00a5a9f6","type":"text","conversion_output":true,"text":"the ICER. To address power for the economic evaluation, we computed the minimum detectable","text_display":" the ICER. To address power for the economic evaluation, we computed the minimum detectable","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1783,1173],[1783,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1540,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e41e9171d2e24b139a06f2043cbe78f2","type":"text","conversion_output":true,"text":"incremental net benefits (INB) for the planned study size. \\({ }^{216}\\) To complete this calculation, a","text_display":" incremental net benefits (INB) for the planned study size. \\({ }^{216}\\) To complete this calculation, a","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1794,1220],[1794,1268],[245,1268]],"region":{"top_left_x":244,"top_left_y":1220,"width":1550,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a1cafbf19ad4dc19c522e14b2615ae7","type":"text","conversion_output":true,"text":"threshold ICER, \\(\\lambda\\), must be specified, which is the maximum one is willing to pay per QALY","text_display":" threshold ICER, \\(\\lambda\\), must be specified, which is the maximum one is willing to pay per QALY","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1712,1268],[1712,1315],[245,1315]],"region":{"top_left_x":244,"top_left_y":1267,"width":1469,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9aeed178b72842da8c26336e923285eb","type":"text","conversion_output":true,"text":"gained. INB is then defined as a function of changes ( \\(\\Delta\\) ) in QALY and costs as follows:","text_display":" gained. INB is then defined as a function of changes ( \\(\\Delta\\) ) in QALY and costs as follows:","confidence":0.9619140625,"confidence_rate":0.9995956009119111},{"cnt":[[245,1313],[1835,1313],[1835,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1312,"width":1591,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07275c734e34404e92d39014581bb266","type":"text","conversion_output":true,"text":"\\(\\lambda^{*} \\Delta\\) QALY- \\(\\Delta\\) Cost. We utilized ICER thresholds \\((\\lambda)\\) of \\(\\$ 25,000, \\$ 50,000\\), and \\(\\$ 100,000\\) in these","text_display":" \\(\\lambda^{*} \\Delta\\) QALY- \\(\\Delta\\) Cost. We utilized ICER thresholds \\((\\lambda)\\) of \\(\\$ 25,000, \\$ 50,000\\), and \\(\\$ 100,000\\) in these","confidence":0.6324562302972847,"confidence_rate":0.996024061908347},{"cnt":[[245,1358],[1841,1358],[1841,1405],[245,1405]],"region":{"top_left_x":244,"top_left_y":1357,"width":1598,"height":49},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6920d559003b4c51b2f4f19a67bb6560","type":"text","conversion_output":true,"text":"computations with \\(\\alpha=0.05\\) (two-sided) and \\(80 \\%\\) power, and utilized variances and covariances","text_display":" computations with \\(\\alpha=0.05\\) (two-sided) and \\(80 \\%\\) power, and utilized variances and covariances","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1760,1401],[1760,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1400,"width":1516,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9075933262504a9db6f59029e30f7d98","type":"text","conversion_output":true,"text":"between QALYs (estimated by SF-6D) and cumulative costs from the observational, non-","text_display":" between QALYs (estimated by SF-6D) and cumulative costs from the observational, non","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[245,1448],[1745,1448],[1745,1493],[245,1493]],"region":{"top_left_x":244,"top_left_y":1448,"width":1501,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8587d4c798da4f71898966f7946247f2","type":"text","conversion_output":true,"text":"operative treatment arms of the Spine Patient Outcomes Research Trial. Although these","text_display":"operative treatment arms of the Spine Patient Outcomes Research Trial. Although these","confidence":1,"confidence_rate":1},{"cnt":[[245,1491],[1824,1491],[1824,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1491,"width":1581,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8dc3152f3b0488ab659f1103bf16334","type":"text","conversion_output":true,"text":"subjects differ from hip fracture patients, they have similar ongoing musculoskeletal concerns","text_display":" subjects differ from hip fracture patients, they have similar ongoing musculoskeletal concerns","confidence":1,"confidence_rate":1},{"cnt":[[245,1536],[1824,1536],[1824,1583],[245,1583]],"region":{"top_left_x":244,"top_left_y":1536,"width":1581,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1125a254a8da45fd912f2fcf8dc546ea","type":"text","conversion_output":true,"text":"and variation in QALYs. For \\(\\lambda\\) 's of \\(\\$ 25,000, \\$ 50,000\\), and \\(\\$ 100,000\\), minimal detectable INBs","text_display":" and variation in QALYs. For \\(\\lambda\\) 's of \\(\\$ 25,000, \\$ 50,000\\), and \\(\\$ 100,000\\), minimal detectable INBs","confidence":0.9960954189300537,"confidence_rate":0.9999630929089357},{"cnt":[[245,1577],[1018,1577],[1018,1626],[245,1626]],"region":{"top_left_x":244,"top_left_y":1576,"width":775,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d885ac4fb6394f06b983592129fce57a","type":"text","conversion_output":true,"text":"are \\(\\$ 2,638, \\$ 4,079\\), and \\(\\$ 7,234\\), respectively.","text_display":" are \\(\\$ 2,638, \\$ 4,079\\), and \\(\\$ 7,234\\), respectively.","confidence":1,"confidence_rate":1},{"cnt":[[241,1663],[1841,1663],[1841,1732],[241,1732]],"region":{"top_left_x":240,"top_left_y":1662,"width":1602,"height":70},"line":30,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"e2d70463f3b74c59aac7240c1791c4f5","type":"section_header","conversion_output":false,"children_ids":["f0f86e82469d43a19fa0078ff4e1cb77"],"text":"","text_display":""},{"cnt":[[245,1669],[1835,1669],[1835,1729],[245,1729]],"region":{"top_left_x":244,"top_left_y":1669,"width":1591,"height":61},"line":31,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"f0f86e82469d43a19fa0078ff4e1cb77","type":"text","conversion_output":true,"parent_id":"e2d70463f3b74c59aac7240c1791c4f5","text":"Section 16: Data Capture, Data Management, and Quality Assurance","text_display":"\n\n\\section*{Section 16: Data Capture, Data Management, and Quality Assurance}","confidence":1,"confidence_rate":1},{"cnt":[[271,1740],[571,1740],[571,1794],[271,1794]],"region":{"top_left_x":270,"top_left_y":1740,"width":302,"height":54},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b380f3c1d764378bd16571d3d0016fc","type":"section_header","conversion_output":false,"children_ids":["120c829c189d475292a6610af67d8a04"],"text":"","text_display":""},{"cnt":[[277,1745],[565,1745],[565,1790],[277,1790]],"region":{"top_left_x":277,"top_left_y":1744,"width":289,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"120c829c189d475292a6610af67d8a04","type":"text","conversion_output":true,"parent_id":"0b380f3c1d764378bd16571d3d0016fc","text":"16.1 Overview","text_display":"\n\n\\subsection*{16.1 Overview}","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1820,1792],[1820,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1576,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6828e8ffe16241b49ed4d8eff4c4426d","type":"text","conversion_output":true,"text":"Data management will be provided under subcontract with Axio Research, LLC, Seattle, WA.","text_display":"\n\nData management will be provided under subcontract with Axio Research, LLC, Seattle, WA.","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1867,1835],[1867,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1623,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d723a91e3cb45518e8e0708ac573134","type":"text","conversion_output":true,"text":"Axio is a contract research organization with over 30 years of experience providing biostatistical","text_display":" Axio is a contract research organization with over 30 years of experience providing biostatistical","confidence":0.9985356330871582,"confidence_rate":0.9999861751885265},{"cnt":[[245,1882],[1740,1882],[1740,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1882,"width":1497,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce6de4bd3b02430db2fa713cd6743ca7","type":"text","conversion_output":true,"text":"and data management support for clinical trials sponsored by the NIH and industry. Axio","text_display":" and data management support for clinical trials sponsored by the NIH and industry. Axio","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1828,1925],[1828,1972],[245,1972]],"region":{"top_left_x":244,"top_left_y":1925,"width":1585,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca75fdef15714e8bb1f8a819abeb1e3c","type":"text","conversion_output":true,"text":"operates under a set of Standard Operating Procedures (SOPs) designed to comply with NIH","text_display":" operates under a set of Standard Operating Procedures (SOPs) designed to comply with NIH","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,1968],[647,1968],[647,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1967,"width":403,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d3e0490a67d43099892baf8d31d1ff7","type":"text","conversion_output":true,"text":"and FDA requirements.","text_display":" and FDA requirements.","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1858,2054],[1858,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2053,"width":1615,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d93ac6bfde9433eb5f40943edce39ad","type":"text","conversion_output":true,"text":"A hybrid system will be employed in which some of the data forms are completed on paper and","text_display":"\n\nA hybrid system will be employed in which some of the data forms are completed on paper and","confidence":1,"confidence_rate":1},{"cnt":[[245,2101],[1766,2101],[1766,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2101,"width":1523,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d71f1a44da704fe9822a29c144e8f432","type":"text","conversion_output":true,"text":"others using a Web form. All data will be stored and cleaned using Clintrial (Oracle/Phase","text_display":" others using a Web form. All data will be stored and cleaned using Clintrial (Oracle/Phase","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1790,2144],[1790,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1546,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99495cfce062438c83d9177acd57b423","type":"text","conversion_output":true,"text":"Forward, Waltham, MA), a commercial clinical data management system in wide use. Data","text_display":" Forward, Waltham, MA), a commercial clinical data management system in wide use. Data","confidence":1,"confidence_rate":1},{"cnt":[[245,2187],[1869,2187],[1869,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2187,"width":1626,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4818366f9eee46b296d2db94bc997c2c","type":"text","conversion_output":true,"text":"collected during intervention visits and telephone interviews will be entered using a Web system","text_display":" collected during intervention visits and telephone interviews will be entered using a Web system","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1790,2230],[1790,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1546,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1b5de576c614278920428ed5b698042","type":"text","conversion_output":true,"text":"developed and validated by Axio. Some forms will be completed on paper and forwarded in","text_display":" developed and validated by Axio. Some forms will be completed on paper and forwarded in","confidence":1,"confidence_rate":1},{"cnt":[[245,2277],[1742,2277],[1742,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2277,"width":1499,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30d80528850a41f7b3b0f7b7c1882a19","type":"text","conversion_output":true,"text":"batches to Axio for processing. This model was chosen to minimize costs and to provide","text_display":" batches to Axio for processing. This model was chosen to minimize costs and to provide","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1742,2320],[1742,2368],[245,2368]],"region":{"top_left_x":244,"top_left_y":2320,"width":1499,"height":48},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22bcbfdc00974087973fd4a86204d20d","type":"text","conversion_output":true,"text":"maximum flexibility for each of the different types of data collection (clinical assessment,","text_display":" maximum flexibility for each of the different types of data collection (clinical assessment,","confidence":1,"confidence_rate":1},{"cnt":[[245,2363],[1867,2363],[1867,2413],[245,2413]],"region":{"top_left_x":244,"top_left_y":2363,"width":1623,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28cdbfbc6977456f96e3bb319616a2cd","type":"text","conversion_output":true,"text":"intervention visit, telephone interview). All systems used in this study will be validated according","text_display":" intervention visit, telephone interview). All systems used in this study will be validated according","confidence":1,"confidence_rate":1},{"cnt":[[245,2406],[1076,2406],[1076,2456],[245,2456]],"region":{"top_left_x":244,"top_left_y":2406,"width":833,"height":50},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3acbd1bc2e04e4eb59605a7033f730f","type":"text","conversion_output":true,"text":"to Axio's SOPs prior to being put into production.","text_display":" to Axio's SOPs prior to being put into production.","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b26749db3464f2392dee8990dd9cfaf","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1830,2587],[1882,2587],[1882,2625],[1830,2625]],"region":{"top_left_x":1830,"top_left_y":2586,"width":53,"height":40},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39e202c44e5c4c549a533906eb02e112","type":"page_info","conversion_output":false,"text":"66","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-086","page":86,"lines":[{"cnt":[[245,249],[1818,249],[1818,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1574,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5060cfc357054e03bbf59951fc113baa","type":"text","conversion_output":true,"text":"Axio will draft and maintain a Data Management Plan (DMP) for this study. This plan outlines","text_display":"\n\nAxio will draft and maintain a Data Management Plan (DMP) for this study. 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Each table in the database will be carefully checked to ensure that all the variables","text_display":" manner. Each table in the database will be carefully checked to ensure that all the variables","confidence":1,"confidence_rate":1},{"cnt":[[245,1669],[1820,1669],[1820,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1669,"width":1576,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d82bd4327244e809ddcd0a9dbd8f935","type":"text","conversion_output":true,"text":"specified on the form have been appropriately entered into the database in the proper format","text_display":" specified on the form have been appropriately entered into the database in the proper format","confidence":0.9980475902557373,"confidence_rate":0.9999798525928524},{"cnt":[[245,1712],[1843,1712],[1843,1760],[245,1760]],"region":{"top_left_x":244,"top_left_y":1712,"width":1600,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5341c72f6cc4c62a61fa6e219fcfc80","type":"text","conversion_output":true,"text":"(e.g. integer, date/time). 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The resulting data from each data table","confidence":1,"confidence_rate":1},{"cnt":[[245,1800],[1682,1800],[1682,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1800,"width":1439,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7d90c46031c47a090985a955e3120ea","type":"text","conversion_output":true,"text":"will be tested to make sure that the entire process results in a database as expected.","text_display":" will be tested to make sure that the entire process results in a database as expected.","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1734,1886],[1734,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1886,"width":1490,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92e98de591274ae7bdd54237bb45dfc9","type":"text","conversion_output":true,"text":"Axio staff will program the data entry screens for the study using Clintrial. 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The screens are programmed","confidence":1,"confidence_rate":1},{"cnt":[[245,1977],[1863,1977],[1863,2024],[245,2024]],"region":{"top_left_x":244,"top_left_y":1976,"width":1619,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a32b80f27244d39a468c2956e2fec24","type":"text","conversion_output":true,"text":"to require that numeric fields be re-keyed by a second data entry technician (double-data entry)","text_display":" to require that numeric fields be re-keyed by a second data entry technician (double-data entry)","confidence":1,"confidence_rate":1},{"cnt":[[245,2020],[554,2020],[554,2067],[245,2067]],"region":{"top_left_x":244,"top_left_y":2019,"width":311,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c01679006d0a44d2aa44b76c47e23421","type":"text","conversion_output":true,"text":"for quality control.","text_display":" for quality control.","confidence":1,"confidence_rate":1},{"cnt":[[245,2108],[1824,2108],[1824,2155],[245,2155]],"region":{"top_left_x":244,"top_left_y":2107,"width":1581,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7400bbf97fdc4ec683cb2a049f4f76a1","type":"text","conversion_output":true,"text":"Axio will define a data cleaning system comprised of: 1 ) computerized data validation rules to","text_display":"\n\nAxio will define a data cleaning system comprised of: 1 ) computerized data validation rules to","confidence":0.643728494644165,"confidence_rate":0.995732643444344},{"cnt":[[245,2153],[1858,2153],[1858,2198],[245,2198]],"region":{"top_left_x":244,"top_left_y":2152,"width":1615,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a426a6cbd195430491951ff1696ebe31","type":"text","conversion_output":true,"text":"check for legitimate/expected values, completeness of data forms, and logical consistency; and","text_display":" check for legitimate/expected values, completeness of data forms, and logical consistency; and","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1828,2196],[1828,2243],[245,2243]],"region":{"top_left_x":244,"top_left_y":2195,"width":1585,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"722ddd5207c64be786145cb9d4be3d3f","type":"text","conversion_output":true,"text":"2 ) manual screening checks. The DCC will review and approve the data edit query definitions","text_display":" 2 ) manual screening checks. The DCC will review and approve the data edit query definitions","confidence":0.8801400661468506,"confidence_rate":0.9986709442061061},{"cnt":[[245,2239],[1871,2239],[1871,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2238,"width":1628,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23761ccb25af4ffa87293fc8036c51a1","type":"text","conversion_output":true,"text":"before Axio begins programming them. A complete list of the data edits will be maintained as an","text_display":" before Axio begins programming them. A complete list of the data edits will be maintained as an","confidence":1,"confidence_rate":1},{"cnt":[[245,2282],[621,2282],[621,2331],[245,2331]],"region":{"top_left_x":244,"top_left_y":2281,"width":377,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bab9440e3b94683b38c8ac65be3362b","type":"text","conversion_output":true,"text":"appendix to the DMP.","text_display":" appendix to the DMP.","confidence":1,"confidence_rate":1},{"cnt":[[245,2372],[1863,2372],[1863,2417],[245,2417]],"region":{"top_left_x":244,"top_left_y":2371,"width":1619,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d946d25ffba41cbaca93578e030fae1","type":"text","conversion_output":true,"text":"Upon receipt of paper CRF data, the data management staff will log receipt into the study study","text_display":"\n\nUpon receipt of paper CRF data, the data management staff will log receipt into the study study","confidence":1,"confidence_rate":1},{"cnt":[[245,2415],[1865,2415],[1865,2462],[245,2462]],"region":{"top_left_x":244,"top_left_y":2414,"width":1621,"height":49},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"408f33feccce481c8acd4d6c1a88c19a","type":"text","conversion_output":true,"text":"management database and will review the data form prior to data entry. Potential problems with","text_display":" management database and will review the data form prior to data entry. Potential problems with","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,2587],[660,2587],[660,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":416,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb5e38de44c54d579d850033ee028eab","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1830,2587],[1882,2587],[1882,2625],[1830,2625]],"region":{"top_left_x":1830,"top_left_y":2586,"width":53,"height":40},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c216dc3c902c4193a12afe505dd8ce6d","type":"page_info","conversion_output":false,"text":"67","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-087","page":87,"lines":[{"cnt":[[245,249],[1854,249],[1854,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1611,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d09409f9bd240958bb984c73daf312a","type":"text","conversion_output":true,"text":"the data (e.g., missing or illegible identification data) will be identified by this screening process","text_display":"\nthe data (e.g., missing or illegible identification data) will be identified by this screening process","confidence":0.99853515625,"confidence_rate":0.9999862999285899},{"cnt":[[245,296],[1863,296],[1863,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1619,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e64ed76bc9347c783cc1b46bdab4d6a","type":"text","conversion_output":true,"text":"and entered into Clintrial as \"ad hoc\" data queries, distributed and tracked for resolution. A data","text_display":" and entered into Clintrial as \"ad hoc\" data queries, distributed and tracked for resolution. A data","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1876,339],[1876,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1632,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eabc08e706694ff3a1155830e4ea1f5e","type":"text","conversion_output":true,"text":"technician will enter the data from each data form page received. A separate data technician will","text_display":" technician will enter the data from each data form page received. A separate data technician will","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1850,382],[1850,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1606,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9e03cd08b6042cca179488c8707d19e","type":"text","conversion_output":true,"text":"verify the first entry by entering the data a second time (blinded double entry-verification). Text","text_display":" verify the first entry by entering the data a second time (blinded double entry-verification). Text","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1154,425],[1154,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":910,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78ef43294b4349b58dca321ef10aff40","type":"text","conversion_output":true,"text":"fields will be visually verified during this second pass.","text_display":" fields will be visually verified during this second pass.","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1691,511],[1691,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1447,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07d8775ca28340dab975c0f407df7bdf","type":"text","conversion_output":true,"text":"Data edit checks will be run as each batch of data is entered and verified. Axio's data","text_display":"\n\nData edit checks will be run as each batch of data is entered and verified. Axio's data","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1846,559],[1846,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1602,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e918713fa67c452ab90959b3c7ea8358","type":"text","conversion_output":true,"text":"coordinator will review the resulting list of problems, determine which problems should be sent","text_display":" coordinator will review the resulting list of problems, determine which problems should be sent","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1738,602],[1738,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1495,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"122ab768b1a14a92a6336c2cc7091de2","type":"text","conversion_output":true,"text":"as queries, and interact with the clinical site staff to clarify issues and answer questions.","text_display":" as queries, and interact with the clinical site staff to clarify issues and answer questions.","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1863,645],[1863,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1619,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c6e64d690804da28fa382750c93327b","type":"text","conversion_output":true,"text":"Queries will be printed to PDF and delivered to the sites via email by the data coordinator. Data","text_display":" Queries will be printed to PDF and delivered to the sites via email by the data coordinator. Data","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1858,692],[1858,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1615,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1a1c553a1844c93b62de9138d641617","type":"text","conversion_output":true,"text":"edit queries will be distributed within one week of receipt of the data forms. Shorter turn-around","text_display":" edit queries will be distributed within one week of receipt of the data forms. Shorter turn-around","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1790,735],[1790,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1546,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d6e62f821734e229bfb7a8d274e513d","type":"text","conversion_output":true,"text":"will be provided in advance of DSMB meetings and towards the end of the study in order to","text_display":" will be provided in advance of DSMB meetings and towards the end of the study in order to","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[746,778],[746,823],[245,823]],"region":{"top_left_x":244,"top_left_y":777,"width":502,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05ec1c83e44b49c2848817f3c9ba619b","type":"text","conversion_output":true,"text":"freeze or close the database.","text_display":" freeze or close the database.","confidence":1,"confidence_rate":1},{"cnt":[[245,864],[1738,864],[1738,913],[245,913]],"region":{"top_left_x":244,"top_left_y":863,"width":1495,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cea4a80e780a411785a92a63ecc17cef","type":"text","conversion_output":true,"text":"Using the query tracking reports, the data coordinator will make sure that all queries are","text_display":"\n\nUsing the query tracking reports, the data coordinator will make sure that all queries are","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1880,911],[1880,958],[245,958]],"region":{"top_left_x":244,"top_left_y":910,"width":1636,"height":49},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"817d101180e744c5b6f760d7c81ad76a","type":"text","conversion_output":true,"text":"promptly and completely addressed, following up on data problems and initiating communication","text_display":" promptly and completely addressed, following up on data problems and initiating communication","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1510,954],[1510,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":953,"width":1267,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f8fdacadd854bb3a3511ce789d081f2","type":"text","conversion_output":true,"text":"when necessary to make sure that data problems are promptly addressed.","text_display":" when necessary to make sure that data problems are promptly addressed.","confidence":1,"confidence_rate":1},{"cnt":[[245,1040],[1850,1040],[1850,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1039,"width":1606,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ad85c7c6aff48f2a987d6086f3133dd","type":"text","conversion_output":true,"text":"Clinical site staff and DCC staff may submit \"ad hoc\" queries that are tracked and processed in","text_display":"\n\nClinical site staff and DCC staff may submit \"ad hoc\" queries that are tracked and processed in","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1087],[1678,1087],[1678,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1434,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e33c8b04e8d4003ae51e7bbb2b62c60","type":"text","conversion_output":true,"text":"the same way as the programmed queries. Clinical site staff may also initiate ad hoc","text_display":" the same way as the programmed queries. Clinical site staff may also initiate ad hoc","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[451,1130],[451,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1130,"width":208,"height":41},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efc5f1ffd0c3463eb9c7cf0d41110413","type":"text","conversion_output":true,"text":"corrections.","text_display":" corrections.","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1820,1216],[1820,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1576,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d83e41b5970945158d48e7ab8779d6e4","type":"text","conversion_output":true,"text":"Clintrial provides a complete 21CFR11-compliant electronic audit trail of all changes made to","text_display":"\n\nClintrial provides a complete 21CFR11-compliant electronic audit trail of all changes made to","confidence":0.8496825695037842,"confidence_rate":0.9983392128104832},{"cnt":[[245,1259],[1858,1259],[1858,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1258,"width":1615,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8936b90bd2ad43dc81bee6d0c2dcfbc4","type":"text","conversion_output":true,"text":"the database. The audit trail includes the name of the person making the change, the date/time","text_display":" the database. The audit trail includes the name of the person making the change, the date/time","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[1016,1302],[1016,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1301,"width":773,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f92d8ecd8b644605ae72b31f4622cdb9","type":"text","conversion_output":true,"text":"of the change and the reason for the change.","text_display":" of the change and the reason for the change.","confidence":1,"confidence_rate":1},{"cnt":[[365,1392],[1059,1392],[1059,1448],[365,1448]],"region":{"top_left_x":365,"top_left_y":1392,"width":695,"height":57},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61786026c11748aa891204fa9a973156","type":"section_header","conversion_output":false,"children_ids":["5c517c0253f24e099fb5350eb8b923d3"],"text":"","text_display":""},{"cnt":[[372,1396],[1055,1396],[1055,1446],[372,1446]],"region":{"top_left_x":371,"top_left_y":1396,"width":684,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c517c0253f24e099fb5350eb8b923d3","type":"text","conversion_output":true,"parent_id":"61786026c11748aa891204fa9a973156","text":"16.3.2 Processing of Web-Entry Data","text_display":"\n\n\\subsection*{16.3.2 Processing of Web-Entry Data}","confidence":1,"confidence_rate":1},{"cnt":[[243,1439],[1850,1439],[1850,1489],[243,1489]],"region":{"top_left_x":242,"top_left_y":1439,"width":1608,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ceb57acb275f4670a785897c3300b502","type":"text","conversion_output":true,"text":"Axio will design, program and validate a password-protected Web-based system for data entry","text_display":"\n\nAxio will design, program and validate a password-protected Web-based system for data entry","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1850,1487],[1850,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1606,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1a54f43fb5641599285122fc86f1e0d","type":"text","conversion_output":true,"text":"of certain of the data forms. The Web system will allow the user to select the participant from a","text_display":" of certain of the data forms. The Web system will allow the user to select the participant from a","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1867,1530],[1867,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":1623,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf1358e5313642889ceff727d8ecbcdc","type":"text","conversion_output":true,"text":"list of participants randomized at the user's site. Entry of the letter code by site staff will be used","text_display":" list of participants randomized at the user's site. Entry of the letter code by site staff will be used","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1725,1573],[1725,1620],[245,1620]],"region":{"top_left_x":244,"top_left_y":1572,"width":1482,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"763a5ede4ecc4d70a2404d767881a480","type":"text","conversion_output":true,"text":"to confirm that the proper participant has been selected. The application will display the","text_display":" to confirm that the proper participant has been selected. The application will display the","confidence":1,"confidence_rate":1},{"cnt":[[245,1616],[1798,1616],[1798,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1615,"width":1555,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea46b502407b4dcd94691e7f2e468e5e","type":"text","conversion_output":true,"text":"assessment times and allow the user to select the assessment time and form for entry. Edit","text_display":" assessment times and allow the user to select the assessment time and form for entry. Edit","confidence":1,"confidence_rate":1},{"cnt":[[245,1661],[1830,1661],[1830,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1660,"width":1587,"height":49},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6bcb3daf8b904a53986e3e0ae87bfdc7","type":"text","conversion_output":true,"text":"checks will be included for within-form logical, completeness and value/range checks. Once a","text_display":" checks will be included for within-form logical, completeness and value/range checks. Once a","confidence":1,"confidence_rate":1},{"cnt":[[245,1704],[1858,1704],[1858,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1703,"width":1615,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"828c8d22861548e59cf67830ba16b996","type":"text","conversion_output":true,"text":"form has been entered and submitted, the link will be disabled. At that point, the application will","text_display":" form has been entered and submitted, the link will be disabled. At that point, the application will","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1760,1749],[1760,1796],[245,1796]],"region":{"top_left_x":244,"top_left_y":1748,"width":1516,"height":49},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4431138fd7fa42c093a75fee52865098","type":"text","conversion_output":true,"text":"generate a print/readable PDF image of the data form that can be downloaded or printed.","text_display":" generate a print/readable PDF image of the data form that can be downloaded or printed.","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1721,1835],[1721,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1477,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"227f1c1c419e4fe3b477ce7da4ec63e0","type":"text","conversion_output":true,"text":"On a daily basis, data from the Web system will be downloaded to the Clintrial (Oracle)","text_display":"\n\nOn a daily basis, data from the Web system will be downloaded to the Clintrial (Oracle)","confidence":1,"confidence_rate":1},{"cnt":[[245,1880],[1772,1880],[1772,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1879,"width":1529,"height":49},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be8e9dbaab634669947491986036ddb1","type":"text","conversion_output":true,"text":"database. Further edits will be applied to the data in Clintrial. Queries and updates to data","text_display":" database. Further edits will be applied to the data in Clintrial. 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The","text_display":"\n\nThe Web system is based on a \"Survey Tool\" that has been in use at Axio for over 5 years. 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The backup system is designed to permit the restoration of the system","text_display":" are archived) as well. The backup system is designed to permit the restoration of the system","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1863,997],[1863,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1619,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01d67976af994978a72abcb801c5a5b4","type":"text","conversion_output":true,"text":"with a minimum expenditure of time and money should any file be destroyed. Every four weeks,","text_display":" with a minimum expenditure of time and money should any file be destroyed. 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Prior to any major change in the operating","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1807,1087],[1807,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1563,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff544d33ba3644d689863de14eebcbee","type":"text","conversion_output":true,"text":"system, backup devices of the main database are created and saved for as long as needed.","text_display":" system, backup devices of the main database are created and saved for as long as needed.","confidence":1,"confidence_rate":1},{"cnt":[[241,1169],[1121,1169],[1121,1222],[241,1222]],"region":{"top_left_x":240,"top_left_y":1168,"width":882,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04114813c5cd4ee1bf188468e0553d88","type":"section_header","conversion_output":false,"children_ids":["fa3f6ddd82ba4a3c8b6d01ae210247f4"],"text":"","text_display":""},{"cnt":[[245,1173],[1115,1173],[1115,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1173,"width":872,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa3f6ddd82ba4a3c8b6d01ae210247f4","type":"text","conversion_output":true,"parent_id":"04114813c5cd4ee1bf188468e0553d88","text":"Economic Evaluation Core at Dartmouth University","text_display":"\n\n\\section*{Economic Evaluation Core at Dartmouth University}","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1772,1216],[1772,1263],[245,1263]],"region":{"top_left_x":244,"top_left_y":1216,"width":1529,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b532333d1a724266a62bf3900727fc90","type":"text","conversion_output":true,"text":"The Economic Evaluation Core (EEC) has offices located at Dartmouth-Hitchcock Medical","text_display":"\n\nThe Economic Evaluation Core (EEC) has offices located at Dartmouth-Hitchcock Medical","confidence":1,"confidence_rate":1},{"cnt":[[245,1261],[1828,1261],[1828,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1261,"width":1585,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3d75fdb280b4a7f92a0fd0b96fde64f","type":"text","conversion_output":true,"text":"Center (DHMC) with computing support provided by The Dartmouth Institute for Health Policy","text_display":" Center (DHMC) with computing support provided by The Dartmouth Institute for Health Policy","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1306],[1820,1306],[1820,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1576,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c6e1732620741d0abc8fb4bb9917e8d","type":"text","conversion_output":true,"text":"and Clinical Practice (TDI) computing services and Geisel School of Medicine Computing. 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For example, training the PTs to deliver the study interventions will be","confidence":0.9990234375,"confidence_rate":0.999990229651252},{"cnt":[[245,1130],[1876,1130],[1876,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1632,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd9aee3256d04183a33cd43f8d5c197c","type":"text","conversion_output":true,"text":"provided by the IM, training in consent, enrollment, and assessment procedures will be provided","text_display":" provided by the IM, training in consent, enrollment, and assessment procedures will be provided","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[1826,1173],[1826,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":1583,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63ab5614f7f143c8a239fbb6dbb56753","type":"text","conversion_output":true,"text":"by the CCC director, while training in randomization and forms completion will be provided by","text_display":" by the CCC director, while training in randomization and forms completion will be provided by","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1785,1216],[1785,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1542,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74409a0c5f744e40a60c21c7cc92da5c","type":"text","conversion_output":true,"text":"the DCC director. Whenever appropriate, trainees will be required to demonstrate acquired","text_display":" the DCC director. Whenever appropriate, trainees will be required to demonstrate acquired","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,1261],[1768,1261],[1768,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1261,"width":1525,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f62227e6331649068b10cda50121d218","type":"text","conversion_output":true,"text":"skills. These demonstrations will be observed and critiqued by the trainers and other staff.","text_display":" skills. These demonstrations will be observed and critiqued by the trainers and other staff.","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1848,1306],[1848,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1604,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3970633af4454b55949e5425504131e6","type":"text","conversion_output":true,"text":"Trainees will be certified to perform study procedures after successfully completing written and","text_display":" Trainees will be certified to perform study procedures after successfully completing written and","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[900,1349],[900,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1349,"width":657,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25ab798c191d4f919d5b56dd629a344d","type":"text","conversion_output":true,"text":"(when appropriate) performance tests.","text_display":" (when appropriate) performance tests.","confidence":0.99951171875,"confidence_rate":0.9999883714843234},{"cnt":[[245,1435],[1815,1435],[1815,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1435,"width":1572,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a455a6f5b7db49b3ade47624c23d2ac4","type":"text","conversion_output":true,"text":"Local recertification sessions will be held annually for all staff groups. In addition to refresher","text_display":"\n\nLocal recertification sessions will be held annually for all staff groups. In addition to refresher","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1878,1482],[1878,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1482,"width":1634,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"103714cfb0494a658631389e9adeefb7","type":"text","conversion_output":true,"text":"training on all study procedures, these sessions will focus on current issues facing the staff, new","text_display":" training on all study procedures, these sessions will focus on current issues facing the staff, new","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1815,1525],[1815,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1572,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13dacddfb42a4a13afcb5a4881380184","type":"text","conversion_output":true,"text":"components implemented in the clinical sites, and problem areas. Recertification procedures","text_display":" components implemented in the clinical sites, and problem areas. Recertification procedures","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1867,1568],[1867,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1623,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d0d537d70324b0a8f4bb1f535718ca0","type":"text","conversion_output":true,"text":"improve compliance with the protocol and the maintenance of study skills over the course of the","text_display":" improve compliance with the protocol and the maintenance of study skills over the course of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1760,1611],[1760,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1516,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b49e74d2bd1444a0a36bf8d9a2e6d3d1","type":"text","conversion_output":true,"text":"trial. The clinical site coordinator will be responsible for documenting that certification and","text_display":" trial. The clinical site coordinator will be responsible for documenting that certification and","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1717,1659],[1717,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1473,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92d1ad1d168444cd96083367f059ca18","type":"text","conversion_output":true,"text":"recertification training has been completed and forwarding that information to the CCC.","text_display":" recertification training has been completed and forwarding that information to the CCC.","confidence":1,"confidence_rate":1},{"cnt":[[365,1740],[1038,1740],[1038,1794],[365,1794]],"region":{"top_left_x":365,"top_left_y":1740,"width":673,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02248caa580c4c10a48f2ad5a22fe424","type":"section_header","conversion_output":false,"children_ids":["ec7637923b3e46f28501a5470ec23d55"],"text":"","text_display":""},{"cnt":[[374,1745],[1033,1745],[1033,1790],[374,1790]],"region":{"top_left_x":373,"top_left_y":1744,"width":661,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec7637923b3e46f28501a5470ec23d55","type":"text","conversion_output":true,"parent_id":"02248caa580c4c10a48f2ad5a22fe424","text":"16.6.2 Quality Assurance Oversight","text_display":"\n\n\\subsection*{16.6.2 Quality Assurance Oversight}","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1790,1788],[1790,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1546,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8882c334d53487c8e088290a436c6f8","type":"text","conversion_output":true,"text":"QA will be a major activity of the CCC and DCC throughout the study. Annual visits to each","text_display":"\n\nQA will be a major activity of the CCC and DCC throughout the study. Annual visits to each","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[1876,1830],[1876,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1830,"width":1632,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"333765172cf64982a916ac672cd8bb17","type":"text","conversion_output":true,"text":"clinical site will be carried out by the directors of the DCC and CCC, accompanied by other DCC","text_display":" clinical site will be carried out by the directors of the DCC and CCC, accompanied by other DCC","confidence":0.9980475902557373,"confidence_rate":0.9999804570091607},{"cnt":[[245,1876],[1867,1876],[1867,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1875,"width":1623,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1755d0806e454629af8b2cd0001888b4","type":"text","conversion_output":true,"text":"and CCC staff, and the outcome of QA visits will be reported to the study chair and the Steering","text_display":" and CCC staff, and the outcome of QA visits will be reported to the study chair and the Steering","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1742,1921],[1742,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1499,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"560e21023efb4493ab3c577a8f03c2b7","type":"text","conversion_output":true,"text":"Committee. Clinical site investigators will be actively engaged in project oversight on an","text_display":" Committee. Clinical site investigators will be actively engaged in project oversight on an","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1828,1964],[1828,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1963,"width":1585,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eeb9204c68604e8cba01040bf985ff0a","type":"text","conversion_output":true,"text":"ongoing basis via regular meetings of the Recruitment and Evaluation SOC. Conference calls","text_display":" ongoing basis via regular meetings of the Recruitment and Evaluation SOC. Conference calls","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,2007],[1757,2007],[1757,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1514,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25fdb8737e3c4102a6ebfdc2f8f66f2f","type":"text","conversion_output":true,"text":"will be used to review study progress, exchange information, and engage in joint problem","text_display":" will be used to review study progress, exchange information, and engage in joint problem","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1648,2054],[1648,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2053,"width":1404,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"897cf82dd7dd49fba76c780be79ba10c","type":"text","conversion_output":true,"text":"solving. Recruitment, follow-up contact and participant retention, adherence to the","text_display":" solving. Recruitment, follow-up contact and participant retention, adherence to the","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1833,2097],[1833,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1589,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7032498ad1c4408a8769a3ac52f83cc9","type":"text","conversion_output":true,"text":"interventions, protocol deviations and AEs will all be monitored. Please refer to the Treatment","text_display":" interventions, protocol deviations and AEs will all be monitored. Please refer to the Treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1274,2140],[1274,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2139,"width":1031,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a627fde02cc94905955082e28e3f3a74","type":"text","conversion_output":true,"text":"Fidelity Plan (section 9.5) for QA related to the interventions.","text_display":" Fidelity Plan (section 9.5) for QA related to the interventions.","confidence":1,"confidence_rate":1},{"cnt":[[367,2221],[866,2221],[866,2271],[367,2271]],"region":{"top_left_x":367,"top_left_y":2221,"width":499,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"face562b6bcf4d50aa32c4efe622be5f","type":"section_header","conversion_output":false,"children_ids":["7caddd4adec74514841a74837cc4c4f6"],"text":"","text_display":""},{"cnt":[[374,2226],[862,2226],[862,2271],[374,2271]],"region":{"top_left_x":373,"top_left_y":2225,"width":489,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7caddd4adec74514841a74837cc4c4f6","type":"text","conversion_output":true,"parent_id":"face562b6bcf4d50aa32c4efe622be5f","text":"16.6.3 Protocol Deviations","text_display":"\n\n\\subsection*{16.6.3 Protocol Deviations}","confidence":1,"confidence_rate":1},{"cnt":[[245,2271],[1867,2271],[1867,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2270,"width":1623,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7722fcd2f2be44e8ac2b3a64d3e78a83","type":"text","conversion_output":true,"text":"Protocol deviations may jeopardize the study by breaching assurances made to the participants","text_display":"\n\nProtocol deviations may jeopardize the study by breaching assurances made to the participants","confidence":0.994140625,"confidence_rate":0.9999400364051435},{"cnt":[[245,2316],[1712,2316],[1712,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":1469,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb47e579e2524d0c9a31fefcef127464","type":"text","conversion_output":true,"text":"or by diminishing the validity of the study. Major deviations will be those that endanger","text_display":" or by diminishing the validity of the study. Major deviations will be those that endanger","confidence":0.9980478286743164,"confidence_rate":0.9999792121384572},{"cnt":[[245,2359],[1729,2359],[1729,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2358,"width":1486,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8e8f00460d5468eac735bf8d7c45139","type":"text","conversion_output":true,"text":"participants, such as failure to protect safety during the interventions, or that undermine","text_display":" participants, such as failure to protect safety during the interventions, or that undermine","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1723,2402],[1723,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1480,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe7e0c253ceb494aba4a63d43e4fe684","type":"text","conversion_output":true,"text":"fundamental premises of the study, such as failure to provide the assigned intervention","text_display":" fundamental premises of the study, such as failure to provide the assigned intervention","confidence":1,"confidence_rate":1},{"cnt":[[245,2447],[1869,2447],[1869,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2447,"width":1626,"height":48},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d1d0a07a9464683a31af9f18571cd63","type":"text","conversion_output":true,"text":"according to protocol or randomizing an ineligible participant. Minor deviations will be those that","text_display":" according to protocol or randomizing an ineligible participant. Minor deviations will be those that","confidence":1,"confidence_rate":1},{"cnt":[[245,2587],[662,2587],[662,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2586,"width":418,"height":38},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"780fdca497cf406da3c4dc61f95bf7aa","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1835,2587],[1886,2587],[1886,2628],[1835,2628]],"region":{"top_left_x":1834,"top_left_y":2586,"width":53,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5af1d89f704247b794f6eb702caabdde","type":"page_info","conversion_output":false,"text":"72","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-092","page":92,"lines":[{"cnt":[[245,249],[1852,249],[1852,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1608,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd0c6bc0ddb74000b8ed26d154dd64dd","type":"text","conversion_output":true,"text":"impede the progress of the study, such as not submitting data in a timely fashion. After the first","text_display":"\nimpede the progress of the study, such as not submitting data in a timely fashion. After the first","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1878,296],[1878,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1634,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65436bbd99dc47f3b4bbe968d8e6e171","type":"text","conversion_output":true,"text":"major deviation, a clinical site will be asked to submit a proposal outlining how recurrence will be","text_display":" major deviation, a clinical site will be asked to submit a proposal outlining how recurrence will be","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1841,339],[1841,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1598,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3b90724e34f436a99d7ec03be2bc7ac","type":"text","conversion_output":true,"text":"prevented. If remedial efforts fail to correct a problem, access to the randomization system will","text_display":" prevented. If remedial efforts fail to correct a problem, access to the randomization system will","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1833,382],[1833,430],[245,430]],"region":{"top_left_x":244,"top_left_y":382,"width":1589,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77d599cc147e4ebd8456ea5eea2a3e1c","type":"text","conversion_output":true,"text":"be suspended and the situation will be reviewed by the SC, DSMB, and/or NIA, depending on","text_display":" be suspended and the situation will be reviewed by the SC, DSMB, and/or NIA, depending on","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1858,425],[1858,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1615,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0a80ac5b85543ddb0974ce53bc5956b","type":"text","conversion_output":true,"text":"the nature of the deviations. This review could result either in more aggressive remedial efforts","text_display":" the nature of the deviations. This review could result either in more aggressive remedial efforts","confidence":1,"confidence_rate":1},{"cnt":[[245,471],[1818,471],[1818,518],[245,518]],"region":{"top_left_x":244,"top_left_y":470,"width":1574,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c875adea9b9d4f4b917df4e677b917f5","type":"text","conversion_output":true,"text":"or in termination of the clinical site. The DCC will document minor deviations in performance","text_display":" or in termination of the clinical site. The DCC will document minor deviations in performance","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1815,516],[1815,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1572,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ef043c4d4924e219fc83216d6e716f9","type":"text","conversion_output":true,"text":"reports, as well as notifying the clinical sites of them. Repeated minor deviations that are not","text_display":" reports, as well as notifying the clinical sites of them. Repeated minor deviations that are not","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1876,559],[1876,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":1632,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88bb30da96bd4fd38ff8775607a870d6","type":"text","conversion_output":true,"text":"corrected may result in suspension of the clinical site. Such a clinical site can only resume study","text_display":" corrected may result in suspension of the clinical site. Such a clinical site can only resume study","confidence":1,"confidence_rate":1},{"cnt":[[245,602],[1755,602],[1755,649],[245,649]],"region":{"top_left_x":244,"top_left_y":601,"width":1512,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02e62a937e07426c8e9eac5580e521c7","type":"text","conversion_output":true,"text":"activities once a corrective action plan has been submitted and approved by the Steering","text_display":" activities once a corrective action plan has been submitted and approved by the Steering","confidence":1,"confidence_rate":1},{"cnt":[[245,645],[1846,645],[1846,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1602,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"551cbcd515ce4d98ac857a14bea27b7a","type":"text","conversion_output":true,"text":"Committee. Clinical sites with enrolled participants will be required to complete data collection","text_display":" Committee. Clinical sites with enrolled participants will be required to complete data collection","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1824,692],[1824,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1581,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"244d0c2372b74dd9bfa2eef382ddfb01","type":"text","conversion_output":true,"text":"for those participants even if randomization is suspended. Prior to separation of a clinical site","text_display":" for those participants even if randomization is suspended. Prior to separation of a clinical site","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1807,735],[1807,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1563,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"272eaa3e21e4464e831fd2aa160a8493","type":"text","conversion_output":true,"text":"from the study, the directors of the DCC and CCC will visit the clinical site and provide a site","text_display":" from the study, the directors of the DCC and CCC will visit the clinical site and provide a site","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,778],[1265,778],[1265,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1022,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef1f93757f5544f99103a45d60706df7","type":"text","conversion_output":true,"text":"visit report to the DSMB for recommendation on final action.","text_display":" visit report to the DSMB for recommendation on final action.","confidence":1,"confidence_rate":1},{"cnt":[[245,864],[1846,864],[1846,913],[245,913]],"region":{"top_left_x":244,"top_left_y":863,"width":1602,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f329ebcadafb451baef40bcab4a4e487","type":"text","conversion_output":true,"text":"Major deviations will be reported promptly by the clinical site to its IRB and to the CCC and will","text_display":"\n\nMajor deviations will be reported promptly by the clinical site to its IRB and to the CCC and will","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1848,911],[1848,958],[245,958]],"region":{"top_left_x":244,"top_left_y":910,"width":1604,"height":49},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cf1d228861445a3bbd47b22a07b9987","type":"text","conversion_output":true,"text":"be tracked at each site using a protocol deviation log, which will then be stored in a study-wide","text_display":" be tracked at each site using a protocol deviation log, which will then be stored in a study-wide","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1738,954],[1738,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":953,"width":1495,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f21c2cc9b097405ca7b390f671ef54ba","type":"text","conversion_output":true,"text":"cumulative report in the CCC. 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Wrong intervention administered to participant","confidence":1,"confidence_rate":1},{"cnt":[[554,1568],[1867,1568],[1867,1618],[554,1618]],"region":{"top_left_x":554,"top_left_y":1568,"width":1313,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b7c59c4475e4391812ed325336b37cb","type":"text","conversion_output":true,"text":"b. Required aspects of intervention not administered (e.g., dietician referral)","text_display":"\nb. 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The DCC will check study","text_display":"\n\nOngoing QA monitoring will be performed by the DCC and the CCC. The DCC will check study","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,1749],[1876,1749],[1876,1796],[245,1796]],"region":{"top_left_x":244,"top_left_y":1748,"width":1632,"height":49},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26bec5b9c7df41deacbc7a52212e3c7c","type":"text","conversion_output":true,"text":"forms to confirm that certified staff are performing study procedures and will perform exploratory","text_display":" forms to confirm that certified staff are performing study procedures and will perform exploratory","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1876,1792],[1876,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1632,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"428974c1de8c456faecfefa51cd359cb","type":"text","conversion_output":true,"text":"statistical investigations of aggregate data to identify unusual patterns and distributions. 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suspension will be recommended based on severity and frequency of occurrence.","confidence":1,"confidence_rate":1},{"cnt":[[245,468],[1051,468],[1051,518],[245,518]],"region":{"top_left_x":244,"top_left_y":468,"width":807,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fcccf038289463b90e94b8eb47f0352","type":"text","conversion_output":true,"text":"The purposes of the monitoring visits will be to:","text_display":"\n\nThe purposes of the monitoring visits will be to:","confidence":1,"confidence_rate":1},{"cnt":[[432,518],[1222,518],[1222,565],[432,565]],"region":{"top_left_x":431,"top_left_y":517,"width":792,"height":49},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5aab7bf531e7444087d73df5592da38f","type":"text","conversion_output":true,"text":"- assure the rights and safety of participants","text_display":"\n- assure the rights and safety of 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Consent by a legally","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1042,649],[1042,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":798,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c80c3d98b2147a0957f75a5664d99ce","type":"text","conversion_output":true,"text":"authorized representative will not be accepted.","text_display":" authorized representative will not be accepted.","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1876,735],[1876,784],[245,784]],"region":{"top_left_x":244,"top_left_y":734,"width":1632,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a44c007d5c934ce5a43b4607b44bdf9b","type":"text","conversion_output":true,"text":"In some cases, a local hospital will allow the use of the clinical site's IRB approved consent form","text_display":"\n\nIn some cases, a local hospital will allow the use of the clinical site's IRB approved consent form","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1850,782],[1850,831],[245,831]],"region":{"top_left_x":244,"top_left_y":782,"width":1606,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44f2bb6d086d41469d9afde009284960","type":"text","conversion_output":true,"text":"and/or the HIPAA Authorization Form. However, clinical site IRBs and local hospital IRBs may","text_display":" and/or the HIPAA Authorization Form. However, clinical site IRBs and local hospital IRBs may","confidence":1,"confidence_rate":1},{"cnt":[[245,827],[1820,827],[1820,874],[245,874]],"region":{"top_left_x":244,"top_left_y":827,"width":1576,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcdb1edca5a74bb79f5b7979d15d6eff","type":"text","conversion_output":true,"text":"require that language be added to the consent form to correspond to local requirements. The","text_display":" require that language be added to the consent form to correspond to local requirements. The","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1833,868],[1833,917],[245,917]],"region":{"top_left_x":244,"top_left_y":867,"width":1589,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6cdf32ce2f854bcf90dd73b90dc4db7a","type":"text","conversion_output":true,"text":"clinical sites will be responsible for ensuring that the correct version of the ICF is used at their","text_display":" clinical sites will be responsible for ensuring that the correct version of the ICF is used at their","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,915],[324,915],[324,956],[245,956]],"region":{"top_left_x":244,"top_left_y":915,"width":81,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6832adb6243a4bb490e12dcbc74b6125","type":"text","conversion_output":true,"text":"site.","text_display":" site.","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1824,1001],[1824,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1581,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"acb449d449074760b0ccc5a3d9e5cd07","type":"text","conversion_output":true,"text":"If there is a change in any of the study procedures or risks that may affect the participant, the","text_display":"\n\nIf there is a change in any of the study procedures or risks that may affect the participant, the","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1755,1044],[1755,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1044,"width":1512,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ef68ac9304a441a944d23c7466306a7","type":"text","conversion_output":true,"text":"ICF must be revised and undergo appropriate IRB review and approval. Any participants","text_display":" ICF must be revised and undergo appropriate IRB review and approval. Any participants","confidence":0.9990236759185791,"confidence_rate":0.9999891467144949},{"cnt":[[245,1087],[1815,1087],[1815,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1087,"width":1572,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71f14aa86a6e447bb9a9a1b78773aa80","type":"text","conversion_output":true,"text":"enrolled in the study prior to such changes and who are still active in the study must sign the","text_display":" enrolled in the study prior to such changes and who are still active in the study must sign the","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[655,1134],[655,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1134,"width":412,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bec98f1af8ee4b59a076215e8c6db228","type":"text","conversion_output":true,"text":"amended consent form.","text_display":" amended consent form.","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1815,1220],[1815,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1220,"width":1572,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c97a129cf5c54470884a3fbe6c4d64ea","type":"text","conversion_output":true,"text":"The study consent form will be provided to a potential participant for review prior to obtaining","text_display":"\n\nThe study consent form will be provided to a potential participant for review prior to obtaining","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1880,1263],[1880,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1263,"width":1636,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"811bb51462c44264b5dd44e0f7322151","type":"text","conversion_output":true,"text":"informed consent. The ICF may also be mailed to the participant and/or a family member so that","text_display":" informed consent. The ICF may also be mailed to the participant and/or a family member so that","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1858,1311],[1858,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1310,"width":1615,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ad80a6938424815a3776e6cf15f361c","type":"text","conversion_output":true,"text":"s/he has sufficient time to read the document and, if desired, to have a family member or friend","text_display":" s/he has sufficient time to read the document and, if desired, to have a family member or friend","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1818,1354],[1818,1401],[245,1401]],"region":{"top_left_x":244,"top_left_y":1353,"width":1574,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5cbd6069b8a477b9ee8006ab3dd971c","type":"text","conversion_output":true,"text":"review the form before signing. During the informed consent process, study staff will provide","text_display":" review the form before signing. During the informed consent process, study staff will provide","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1863,1396],[1863,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1619,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d52ab78bf9d4eb98e7b04cd6378a402","type":"text","conversion_output":true,"text":"participants with adequate information concerning the study procedures, respond to individual'","text_display":" participants with adequate information concerning the study procedures, respond to individual'","confidence":0.7279233932495117,"confidence_rate":0.996797467714077},{"cnt":[[245,1439],[1742,1439],[1742,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1499,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fef5b00eadbd43eabea2a00998e849d7","type":"text","conversion_output":true,"text":"questions and concerns, and ensure that each individual understands all the information","text_display":" questions and concerns, and ensure that each individual understands all the information","confidence":1,"confidence_rate":1},{"cnt":[[245,1485],[1824,1485],[1824,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1484,"width":1581,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f222c13d65c74f6db4d21e53c7182db2","type":"text","conversion_output":true,"text":"provided by assessing ability to provide informed consent. A more detailed description of the","text_display":" provided by assessing ability to provide informed consent. A more detailed description of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1171,1530],[1171,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":927,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5bff784ebfe48f3b1559380087332b6","type":"text","conversion_output":true,"text":"informed consent process can be found in section 7.6.","text_display":" informed consent process can be found in section 7.6.","confidence":1,"confidence_rate":1},{"cnt":[[365,1609],[1231,1609],[1231,1669],[365,1669]],"region":{"top_left_x":365,"top_left_y":1609,"width":867,"height":61},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae6c5851506e4b599c3076342fece9eb","type":"section_header","conversion_output":false,"children_ids":["8daa14eaa3d9470f93fc98d7a25f3fd9"],"text":"","text_display":""},{"cnt":[[372,1616],[1222,1616],[1222,1663],[372,1663]],"region":{"top_left_x":371,"top_left_y":1615,"width":852,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8daa14eaa3d9470f93fc98d7a25f3fd9","type":"text","conversion_output":true,"parent_id":"ae6c5851506e4b599c3076342fece9eb","text":"17.2.1 Disposition of Informed Consent Forms","text_display":"\n\n\\subsection*{17.2.1 Disposition of Informed Consent Forms}","confidence":1,"confidence_rate":1},{"cnt":[[245,1661],[1876,1661],[1876,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1660,"width":1632,"height":49},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fea270fa0f248e0a62a5e94b20f31d6","type":"text","conversion_output":true,"text":"Because ICFs contain subject identifiers and protected health information (PHI), these forms will","text_display":"\n\nBecause ICFs contain subject identifiers and protected health information (PHI), these forms will","confidence":0.7700422927737236,"confidence_rate":0.9974414175897269},{"cnt":[[245,1704],[1871,1704],[1871,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1703,"width":1628,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d11e7f325c394274ad784d94655ef330","type":"text","conversion_output":true,"text":"not be submitted with the data collection forms. Originals of the ICF will be filed and maintained","text_display":" not be submitted with the data collection forms. Originals of the ICF will be filed and maintained","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1867,1749],[1867,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1623,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6f86c3fba464649b30401762fd21f4b","type":"text","conversion_output":true,"text":"by the clinical site coordinator in the participant binder which will be secured in a locked cabinet","text_display":" by the clinical site coordinator in the participant binder which will be secured in a locked cabinet","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1828,1792],[1828,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1585,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f76935b2a4d94559943559efa9d052cc","type":"text","conversion_output":true,"text":"or office, separate from source documents that include no PHI. A copy of the signed consent","text_display":" or office, separate from source documents that include no PHI. A copy of the signed consent","confidence":0.998046875,"confidence_rate":0.9999796352611579},{"cnt":[[245,1835],[1846,1835],[1846,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1602,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4628918456904a8bba4e458ef1be8078","type":"text","conversion_output":true,"text":"form will be given to the participant and this fact will be documented in the participant's record.","text_display":" form will be given to the participant and this fact will be documented in the participant's record.","confidence":1,"confidence_rate":1},{"cnt":[[365,1916],[887,1916],[887,1972],[365,1972]],"region":{"top_left_x":365,"top_left_y":1916,"width":523,"height":57},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ee244347c684e1ca52194e2c1df0aff","type":"section_header","conversion_output":false,"children_ids":["0d33bb3941644f4abeece0364d9cae51"],"text":"","text_display":""},{"cnt":[[372,1925],[879,1925],[879,1966],[372,1966]],"region":{"top_left_x":371,"top_left_y":1925,"width":508,"height":41},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d33bb3941644f4abeece0364d9cae51","type":"text","conversion_output":true,"parent_id":"6ee244347c684e1ca52194e2c1df0aff","text":"17.2.2 HIPAA Authorization","text_display":"\n\n\\subsection*{17.2.2 HIPAA Authorization}","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1824,1968],[1824,2015],[245,2015]],"region":{"top_left_x":244,"top_left_y":1967,"width":1581,"height":49},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"518c2536e2ca4c86afa69b52b2a27032","type":"text","conversion_output":true,"text":"The HIPAA Authorization for Research is an individual's signed permission to allow the study","text_display":"\n\nThe HIPAA Authorization for Research is an individual's signed permission to allow the study","confidence":0.998046875,"confidence_rate":0.9999798452048033},{"cnt":[[245,2011],[1798,2011],[1798,2058],[245,2058]],"region":{"top_left_x":244,"top_left_y":2010,"width":1555,"height":49},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"254aa33d9e134e30ab8b28c019274e58","type":"text","conversion_output":true,"text":"investigators to use or disclose the individual's PHI described in the authorization. Once an","text_display":" investigators to use or disclose the individual's PHI described in the authorization. Once an","confidence":0.9824380874633789,"confidence_rate":0.999819220908543},{"cnt":[[245,2056],[1721,2056],[1721,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2056,"width":1477,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"360a04f798b043428bacc4201e6c0e55","type":"text","conversion_output":true,"text":"individual has agreed to participate in the study and written informed consent has been","text_display":" individual has agreed to participate in the study and written informed consent has been","confidence":1,"confidence_rate":1},{"cnt":[[245,2101],[1760,2101],[1760,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2101,"width":1516,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb40c8f9eaa945fe9b6788183fd95a12","type":"text","conversion_output":true,"text":"obtained, the HIPAA Authorization for Research must also be explained and signed. The","text_display":" obtained, the HIPAA Authorization for Research must also be explained and signed. The","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1824,2144],[1824,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2144,"width":1581,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25f921367d6d400aa53c2d8e226614f1","type":"text","conversion_output":true,"text":"HIPAA Authorization may be a stand-alone document or wording for the HIPAA Authorization","text_display":" HIPAA Authorization may be a stand-alone document or wording for the HIPAA Authorization","confidence":1,"confidence_rate":1},{"cnt":[[245,2187],[1867,2187],[1867,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2187,"width":1623,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccc66f8827784221bf8a36f8655827d9","type":"text","conversion_output":true,"text":"may be incorporated into the text of the ICF. The original signed authorization will be submitted","text_display":" may be incorporated into the text of the ICF. The original signed authorization will be submitted","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1394,2230],[1394,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1151,"height":50},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25503f37bdfe448aa1193f9c31a59f79","type":"text","conversion_output":true,"text":"to the study office and a signed copy will be given to the participant.","text_display":" to the study office and a signed copy will be given to the participant.","confidence":1,"confidence_rate":1},{"cnt":[[271,2314],[904,2314],[904,2376],[271,2376]],"region":{"top_left_x":270,"top_left_y":2313,"width":635,"height":64},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08289d0e573f44eab1fae1d3301f4d81","type":"section_header","conversion_output":false,"children_ids":["27cc1928f27a4e6990d2a8ba3f96303b"],"text":"","text_display":""},{"cnt":[[279,2320],[896,2320],[896,2370],[279,2370]],"region":{"top_left_x":279,"top_left_y":2320,"width":617,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27cc1928f27a4e6990d2a8ba3f96303b","type":"text","conversion_output":true,"parent_id":"08289d0e573f44eab1fae1d3301f4d81","text":"17.3 Participant Confidentiality","text_display":"\n\n\\subsection*{17.3 Participant Confidentiality}","confidence":0.9990234375,"confidence_rate":0.9999735938716796},{"cnt":[[245,2368],[1811,2368],[1811,2415],[245,2415]],"region":{"top_left_x":244,"top_left_y":2367,"width":1568,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c11f01a80b9542719961b5f859b18203","type":"text","conversion_output":true,"text":"Potential participants will be provided with a clear understanding of how the information they","text_display":"\n\nPotential participants will be provided with a clear understanding of how the information they","confidence":1,"confidence_rate":1},{"cnt":[[245,2411],[1880,2411],[1880,2460],[245,2460]],"region":{"top_left_x":244,"top_left_y":2410,"width":1636,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f31ec1df91ba4d5d87801504d1e33d63","type":"text","conversion_output":true,"text":"provide will be used. All investigators and staff involved in the study will be required to complete","text_display":" provide will be used. 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These web-based tools must meet HIPAA guidelines to ensure","text_display":" or other online communications. 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Identification","text_display":" The study records will be identified by a unique participant identification number. Identification","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1850,1349],[1850,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1349,"width":1606,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cacd9b8e6468476a8def7fa5319322ca","type":"text","conversion_output":true,"text":"numbers will be recorded on each page of the paper forms. The participant's letter code and a","text_display":" numbers will be recorded on each page of the paper forms. The participant's letter code and a","confidence":1,"confidence_rate":1},{"cnt":[[245,1392],[1854,1392],[1854,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1392,"width":1611,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"963f3ec5b0c04bd58d71e9769a4aca85","type":"text","conversion_output":true,"text":"study status date (e.g., date of randomization) will be used as a second level of check. Names","text_display":" study status date (e.g., date of randomization) will be used as a second level of check. 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Final analysis data sets will not contain any directly or indirectly","text_display":" files at the clinical sites. Final analysis data sets will not contain any directly or indirectly","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1738,1525],[1738,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1495,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9832afbad72b4094832a45201f906ec5","type":"text","conversion_output":true,"text":"identifying information. Thus, dates of birth will be converted to age, other dates will be","text_display":" identifying information. 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A de-identified data","text_display":" and administrative data (e.g., edit trail) will not be included in this data file. A de-identified data","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1714,1921],[1714,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1471,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1931a29cff684315a06c947f2c242aa1","type":"text","conversion_output":true,"text":"set will be created which merges all the essential data from all time points of the study.","text_display":" set will be created which merges all the essential data from all time points of the study.","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1850,1964],[1850,2011],[245,2011]],"region":{"top_left_x":244,"top_left_y":1963,"width":1606,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"276c7a98438447eda35b26462f56e763","type":"text","conversion_output":true,"text":"Documentation (including abstracts of published works and calculated variable definitions) and","text_display":" Documentation (including abstracts of published works and calculated variable definitions) and","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1876,2007],[1876,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1632,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03308d86ace2442989f82af88423cab6","type":"text","conversion_output":true,"text":"form images will be included with the data file. The data file will be provided to the NIA/NIH after","text_display":" form images will be included with the data file. The data file will be provided to the NIA/NIH after","confidence":1,"confidence_rate":1},{"cnt":[[245,2052],[1790,2052],[1790,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2051,"width":1546,"height":49},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6609d891c7041999f1697a4a99b2083","type":"text","conversion_output":true,"text":"the end of the period of funding for sharing with other investigators according to NIH policy.","text_display":" the end of the period of funding for sharing with other investigators according to NIH policy.","confidence":1,"confidence_rate":1},{"cnt":[[241,2136],[1197,2136],[1197,2204],[241,2204]],"region":{"top_left_x":240,"top_left_y":2135,"width":957,"height":70},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d587fa8980449dfbfe32370d168a1c6","type":"section_header","conversion_output":false,"children_ids":["f3fa3c8d699c44e7a11132bf2fa7039a"],"text":"","text_display":""},{"cnt":[[245,2140],[1190,2140],[1190,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2139,"width":947,"height":64},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3fa3c8d699c44e7a11132bf2fa7039a","type":"text","conversion_output":true,"parent_id":"7d587fa8980449dfbfe32370d168a1c6","text":"Section 18: Research Publication Policy","text_display":"\n\n\\section*{Section 18: Research Publication Policy}","confidence":1,"confidence_rate":1},{"cnt":[[245,2213],[1837,2213],[1837,2262],[245,2262]],"region":{"top_left_x":244,"top_left_y":2212,"width":1593,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05afc70282db4b3a86e62fd8834a84a6","type":"text","conversion_output":true,"text":"Publications will be operationally defined as manuscripts for publication; abstracts for platform","text_display":"\n\nPublications will be operationally defined as manuscripts for publication; abstracts for platform","confidence":1,"confidence_rate":1},{"cnt":[[245,2260],[1820,2260],[1820,2307],[245,2307]],"region":{"top_left_x":244,"top_left_y":2260,"width":1576,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13b88428bab04e4784c00314f1749c9a","type":"text","conversion_output":true,"text":"or poster presentation at scientific and other professional meetings; slides for presentation at","text_display":" or poster presentation at scientific and other professional meetings; slides for presentation at","confidence":1,"confidence_rate":1},{"cnt":[[245,2303],[1710,2303],[1710,2353],[245,2353]],"region":{"top_left_x":244,"top_left_y":2303,"width":1467,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0534dd8caa3c414d8a8789f23641b9d6","type":"text","conversion_output":true,"text":"scientific and other professional meetings; doctoral dissertations; and master's theses.","text_display":" scientific and other professional meetings; doctoral dissertations; and master's theses.","confidence":0.9673309326171875,"confidence_rate":0.999642917360616},{"cnt":[[245,2391],[1843,2391],[1843,2438],[245,2438]],"region":{"top_left_x":244,"top_left_y":2391,"width":1600,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbbd3f0b213c4f92bdb04e4086e1449b","type":"text","conversion_output":true,"text":"The goal of our publication policy is to encourage and facilitate the publication of study results.","text_display":"\n\nThe goal of our publication policy is to encourage and facilitate the publication of study results.","confidence":1,"confidence_rate":1},{"cnt":[[245,2436],[1760,2436],[1760,2486],[245,2486]],"region":{"top_left_x":244,"top_left_y":2436,"width":1516,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06f97074b87e4836acdc21be5f0c2692","type":"text","conversion_output":true,"text":"The purposes of this policy are to ensure the following: 1) CAP publications will be of the","text_display":" The purposes of this policy are to ensure the following: 1) CAP publications will be of the","confidence":1,"confidence_rate":1},{"cnt":[[245,2585],[662,2585],[662,2623],[245,2623]],"region":{"top_left_x":244,"top_left_y":2584,"width":418,"height":40},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc05bbd65e39426893bcb49453c25218","type":"page_info","conversion_output":false,"text":"CAP Protocol version 12.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1833,2587],[1882,2587],[1882,2625],[1833,2625]],"region":{"top_left_x":1832,"top_left_y":2586,"width":51,"height":40},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39a85f9119aa499aabb4541ce0163c62","type":"page_info","conversion_output":false,"text":"76","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2efa872f-7404-4e9a-b558-82f18459fdff-096","page":96,"lines":[{"cnt":[[245,249],[1880,249],[1880,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1636,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9631d6bbdb1e40f6befbe60f43e288ea","type":"text","conversion_output":true,"text":"highest scientific quality; 2) CAP will be described in a consistent manner across publications; 3 )","text_display":"\nhighest scientific quality; 2) CAP will be described in a consistent manner across publications; 3 )","confidence":0.5056275632232428,"confidence_rate":0.9937054964889327},{"cnt":[[245,296],[1878,296],[1878,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1634,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38e5375daa474d40b00c071afed986e8","type":"text","conversion_output":true,"text":"measures are reported in consistent ways across publications; 4) proper acknowledgements are","text_display":" measures are reported in consistent ways across publications; 4) proper acknowledgements are","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1854,339],[1854,387],[245,387]],"region":{"top_left_x":244,"top_left_y":339,"width":1611,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1927c7f09234ea2aa5c168d5d8a8f49","type":"text","conversion_output":true,"text":"included; and 4) appropriate authorship credit is determined prior to submission of manuscripts","text_display":" included; and 4) appropriate authorship credit is determined prior to submission of manuscripts","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,382],[741,382],[741,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":498,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"598096b6eb3f4660b33b32380a30a5a5","type":"text","conversion_output":true,"text":"for publication consideration.","text_display":" for publication consideration.","confidence":0.99951171875,"confidence_rate":0.9999860457974148},{"cnt":[[245,468],[1815,468],[1815,518],[245,518]],"region":{"top_left_x":244,"top_left_y":468,"width":1572,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"183a4d1d4ac34f14a7fd14ce5e164576","type":"text","conversion_output":true,"text":"Publications from CAP will be overseen by the Publications and Ancillary Studies Committee","text_display":"\n\nPublications from CAP will be overseen by the Publications and Ancillary Studies Committee","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1794,511],[1794,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1550,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e75000516eb44eb19e2205acce02b9f8","type":"text","conversion_output":true,"text":"(PASC). In addition to committee co-chairs, the PASC will have at least one representative","text_display":" (PASC). In addition to committee co-chairs, the PASC will have at least one representative","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1867,559],[1867,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1623,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd288d11e64748579720c7ecc0a7b9d6","type":"text","conversion_output":true,"text":"from the DCC, CCC, EEC, and each clinical site. The PASC will make recommendations to the","text_display":" from the DCC, CCC, EEC, and each clinical site. The PASC will make recommendations to the","confidence":0.99072265625,"confidence_rate":0.9999008491037157},{"cnt":[[243,602],[316,602],[316,642],[243,642]],"region":{"top_left_x":242,"top_left_y":601,"width":74,"height":42},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c645c31ab726416b8873f0151c255ebc","type":"text","conversion_output":true,"text":"SC.","text_display":" SC.","confidence":0.99072265625,"confidence_rate":0.9988355976514217},{"cnt":[[243,688],[1820,688],[1820,737],[243,737]],"region":{"top_left_x":242,"top_left_y":687,"width":1578,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51f9eefbaaa44434991681ce7ea709a6","type":"text","conversion_output":true,"text":"A document describing the CAP Publication Policy and Procedures appears in the Manual of","text_display":"\n\nA document describing the CAP Publication Policy and Procedures appears in the Manual of","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[458,735],[458,776],[245,776]],"region":{"top_left_x":244,"top_left_y":734,"width":214,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d829824dc804b26bd7381ea9e2d2289","type":"text","conversion_output":true,"text":"Procedures.","text_display":" Procedures.","confidence":1,"confidence_rate":1},{"cnt":[[241,816],[1130,816],[1130,885],[241,885]],"region":{"top_left_x":240,"top_left_y":816,"width":891,"height":70},"line":11,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"cca09770f5f243c0ac0e607863ba353c","type":"section_header","conversion_output":false,"children_ids":["4ef7e93b194a4aad86aec700e6f40e8f"],"text":"","text_display":""},{"cnt":[[245,821],[1128,821],[1128,883],[245,883]],"region":{"top_left_x":244,"top_left_y":820,"width":884,"height":64},"line":12,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"4ef7e93b194a4aad86aec700e6f40e8f","type":"text","conversion_output":true,"parent_id":"cca09770f5f243c0ac0e607863ba353c","text":"Section 19: Ancillary Studies Policies","text_display":"\n\n\\section*{Section 19: Ancillary Studies Policies}","confidence":1,"confidence_rate":1},{"cnt":[[245,898],[1751,898],[1751,947],[245,947]],"region":{"top_left_x":244,"top_left_y":898,"width":1507,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d061e18ca1144589636871f76340e5f","type":"text","conversion_output":true,"text":"An ancillary study will be defined as a study that (1) uses supplementary data that will be","text_display":"\n\nAn ancillary study will be defined as a study that (1) uses supplementary data that will be","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,941],[1854,941],[1854,990],[245,990]],"region":{"top_left_x":244,"top_left_y":941,"width":1611,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fae0ee9ffc04fd2937e2f7add8294e7","type":"text","conversion_output":true,"text":"collected on participants who are recruited in CAP, over and above the data collection required","text_display":" collected on participants who are recruited in CAP, over and above the data collection required","confidence":1,"confidence_rate":1},{"cnt":[[245,988],[1858,988],[1858,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":988,"width":1615,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96d1695a2cb74c658b472fc1296ea2a9","type":"text","conversion_output":true,"text":"by the CAP protocol, (2) collects biological specimens (e.g., blood) or performs diagnostic tests","text_display":" by the CAP protocol, (2) collects biological specimens (e.g., blood) or performs diagnostic tests","confidence":0.99267578125,"confidence_rate":0.9999279322780712},{"cnt":[[245,1031],[1871,1031],[1871,1079],[245,1079]],"region":{"top_left_x":244,"top_left_y":1031,"width":1628,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ec46d7d099f44aead37e769af63767a","type":"text","conversion_output":true,"text":"(e.g., bone density scans); and/or (3) collects data on subjects not enrolled in CAP but who may","text_display":" (e.g., bone density scans); and/or (3) collects data on subjects not enrolled in CAP but who may","confidence":0.85986328125,"confidence_rate":0.9985062466858582},{"cnt":[[245,1074],[1721,1074],[1721,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1074,"width":1477,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"531166c1c89c492ca28801a583fce9f1","type":"text","conversion_output":true,"text":"be compared to CAP subjects (e.g., participants who receive an alternate intervention).","text_display":" be compared to CAP subjects (e.g., participants who receive an alternate intervention).","confidence":1,"confidence_rate":1},{"cnt":[[245,1117],[1835,1117],[1835,1164],[245,1164]],"region":{"top_left_x":244,"top_left_y":1117,"width":1591,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39456c9101d24bbc901706d9df5dac3d","type":"text","conversion_output":true,"text":"Ancillary studies will be distinct from databank studies, which use data previously collected on","text_display":" Ancillary studies will be distinct from databank studies, which use data previously collected on","confidence":1,"confidence_rate":1},{"cnt":[[245,1160],[881,1160],[881,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1160,"width":637,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7afdd6c4fa541159f8dc2ffbe4e4bed","type":"text","conversion_output":true,"text":"participants who are enrolled in CAP.","text_display":" participants who are enrolled in CAP.","confidence":1,"confidence_rate":1},{"cnt":[[245,1250],[1790,1250],[1790,1298],[245,1298]],"region":{"top_left_x":244,"top_left_y":1250,"width":1546,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1646bb5653724b71bea1fffb5e377550","type":"text","conversion_output":true,"text":"Ancillary studies will be reviewed and approved by the PASC and ratified by the SC prior to","text_display":"\n\nAncillary studies will be reviewed and approved by the PASC and ratified by the SC prior to","confidence":1,"confidence_rate":1},{"cnt":[[245,1293],[1858,1293],[1858,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1293,"width":1615,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8be05d74fe65410f8330dffb7d36085f","type":"text","conversion_output":true,"text":"initiation to ensure that they do not conflict with the main study protocol. All approved ancillary","text_display":" initiation to ensure that they do not conflict with the main study protocol. All approved ancillary","confidence":1,"confidence_rate":1},{"cnt":[[245,1336],[1850,1336],[1850,1386],[245,1386]],"region":{"top_left_x":244,"top_left_y":1336,"width":1606,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e289998800f4e50a6b12a65abeaf385","type":"text","conversion_output":true,"text":"studies will also be reviewed by the DSMB and NIA prior to initiation. If approved, the ancillary","text_display":" studies will also be reviewed by the DSMB and NIA prior to initiation. If approved, the ancillary","confidence":1,"confidence_rate":1},{"cnt":[[245,1384],[1863,1384],[1863,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1383,"width":1619,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74faf35c6a584581bc5024ee60ae08aa","type":"text","conversion_output":true,"text":"study PI will report to the DSMB on the same schedule as the main study. Review by the PASC","text_display":" study PI will report to the DSMB on the same schedule as the main study. Review by the PASC","confidence":0.9970703125,"confidence_rate":0.9999694380979121},{"cnt":[[245,1427],[1837,1427],[1837,1474],[245,1474]],"region":{"top_left_x":244,"top_left_y":1426,"width":1593,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69be43d5449f412a8992aaa2976dda61","type":"text","conversion_output":true,"text":"(and approval by the SC) will also be required for presentation or publication of ancillary study","text_display":" (and approval by the SC) will also be required for presentation or publication of ancillary study","confidence":1,"confidence_rate":1},{"cnt":[[245,1470],[376,1470],[376,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1469,"width":132,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad77052f3de847488b3cb71d59f18846","type":"text","conversion_output":true,"text":"results.","text_display":" results.","confidence":1,"confidence_rate":1},{"cnt":[[245,1555],[1712,1555],[1712,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1555,"width":1469,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9764d92c5e2f4b41b49cfb485ad3dda2","type":"text","conversion_output":true,"text":"CAP investigators will be encouraged to consider ancillary studies and to involve other","text_display":"\n\nCAP investigators will be encouraged to consider ancillary studies and to involve other","confidence":1,"confidence_rate":1},{"cnt":[[245,1603],[1798,1603],[1798,1648],[245,1648]],"region":{"top_left_x":244,"top_left_y":1602,"width":1555,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d012ee2d55c64175a9d368606b988876","type":"text","conversion_output":true,"text":"investigators, within and outside of CAP personnel. Participation in an ancillary study will be","text_display":" investigators, within and outside of CAP personnel. Participation in an ancillary study will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1646],[1717,1646],[1717,1691],[245,1691]],"region":{"top_left_x":244,"top_left_y":1645,"width":1473,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7174daba32684a8dbcc6a2989f8a689e","type":"text","conversion_output":true,"text":"subject to the approval of the CAP PASC, SC, and DSMB, The following factors will be","text_display":" subject to the approval of the CAP PASC, SC, and DSMB, The following factors will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1356,1689],[1356,1738],[245,1738]],"region":{"top_left_x":244,"top_left_y":1688,"width":1112,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e25c7d3cbf0348d2884431ae7f0657d7","type":"text","conversion_output":true,"text":"considered in determining approval of a proposed ancillary study:","text_display":" considered in determining approval of a proposed ancillary study:","confidence":1,"confidence_rate":1},{"cnt":[[245,1732],[625,1732],[625,1781],[245,1781]],"region":{"top_left_x":244,"top_left_y":1731,"width":382,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44eb2571e35f43eca5181abd71d1e99b","type":"text","conversion_output":true,"text":"1. Participant burden","text_display":"\n1. Participant burden","confidence":1,"confidence_rate":1},{"cnt":[[370,1777],[1800,1777],[1800,1824],[370,1824]],"region":{"top_left_x":369,"top_left_y":1776,"width":1432,"height":49},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebf5455b9b5343aba462076b08943499","type":"text","conversion_output":true,"text":"a. The proposed study must be acceptable to the participants (e.g. in terms of time,","text_display":"\na. The proposed study must be acceptable to the participants (e.g. in terms of time,","confidence":1,"confidence_rate":1},{"cnt":[[432,1822],[782,1822],[782,1867],[432,1867]],"region":{"top_left_x":431,"top_left_y":1821,"width":352,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0861f8581f047da8fb149ee08266236","type":"text","conversion_output":true,"text":"discomfort, privacy).","text_display":" discomfort, privacy).","confidence":1,"confidence_rate":1},{"cnt":[[370,1865],[1871,1865],[1871,1912],[370,1912]],"region":{"top_left_x":369,"top_left_y":1864,"width":1503,"height":49},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5385b60e90cc40e2ba433aa552229b80","type":"text","conversion_output":true,"text":"b. The proposed study must not reduce enrollment or hamper continued participation in","text_display":"\nb. The proposed study must not reduce enrollment or hamper continued participation in","confidence":1,"confidence_rate":1},{"cnt":[[430,1908],[698,1908],[698,1957],[430,1957]],"region":{"top_left_x":429,"top_left_y":1907,"width":270,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e65c6e3e859b4d31bfe9088bcc4dfdc3","type":"text","conversion_output":true,"text":"the main study.","text_display":" the main study.","confidence":1,"confidence_rate":1},{"cnt":[[245,1951],[627,1951],[627,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1950,"width":384,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"829db79a5bf74cf7891f5945a0ce6754","type":"text","conversion_output":true,"text":"2. Study interference","text_display":"\n2. Study interference","confidence":1,"confidence_rate":1},{"cnt":[[370,1998],[1669,1998],[1669,2043],[370,2043]],"region":{"top_left_x":369,"top_left_y":1998,"width":1301,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee3ae43a228f4e7180d86721c4c360cc","type":"text","conversion_output":true,"text":"a. The proposed study must not interfere with other parts of the main study.","text_display":"\na. The proposed study must not interfere with other parts of the main study.","confidence":1,"confidence_rate":1},{"cnt":[[370,2041],[1641,2041],[1641,2086],[370,2086]],"region":{"top_left_x":369,"top_left_y":2041,"width":1273,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b92afa2cf114e82bc4b3cb2f2bcb063","type":"text","conversion_output":true,"text":"b. The proposed study must put no additional demand on CAP resources.","text_display":"\nb. The proposed study must put no additional demand on CAP resources.","confidence":1,"confidence_rate":1},{"cnt":[[245,2084],[1300,2084],[1300,2133],[245,2133]],"region":{"top_left_x":244,"top_left_y":2083,"width":1056,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"927f98cb35ae49658138dd29d0e373eb","type":"text","conversion_output":true,"text":"3. The proposed study must be of the highest scientific merit.","text_display":"\n3. The proposed study must be of the highest scientific merit.","confidence":1,"confidence_rate":1},{"cnt":[[245,2127],[1858,2127],[1858,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2126,"width":1615,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93168679fe174e3baddc7c95044c731f","type":"text","conversion_output":true,"text":"4. The investigators must have adequate resources to effectively complete the ancillary study,","text_display":"\n4. 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