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Safety and additional treatments: To describe rates of reoperation (sling revision) for worsening","confidence":1,"confidence_rate":1},{"cnt":[[271,610],[1815,610],[1815,655],[271,655]],"region":{"top_left_x":270,"top_left_y":610,"width":1546,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afb8eea0640b44b3b0414e46abb2c6b8","type":"text","conversion_output":true,"text":"OAB symptoms after MUS and to compare the proportion of women in each group initiating","text_display":" OAB symptoms after MUS and to compare the proportion of women in each group initiating","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[271,655],[1944,655],[1944,698],[271,698]],"region":{"top_left_x":270,"top_left_y":655,"width":1675,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66124382a4f5424dbb2822c8bb54cc70","type":"text","conversion_output":true,"text":"additional treatment for SUI and/or OAB, and the types of additional treatment (BPTx, medications,","text_display":" additional treatment for SUI and/or OAB, and the types of additional treatment (BPTx, medications,","confidence":1,"confidence_rate":1},{"cnt":[[271,700],[380,700],[380,741],[271,741]],"region":{"top_left_x":270,"top_left_y":700,"width":111,"height":42},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90c5dc25bd4d45e88d23c56384e7372f","type":"text","conversion_output":true,"text":"other)","text_display":" other)","confidence":1,"confidence_rate":1},{"cnt":[[271,786],[1837,786],[1837,831],[271,831]],"region":{"top_left_x":270,"top_left_y":786,"width":1567,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6b773ae0bac41e7b16ecad5bb0d73fc","type":"text","conversion_output":true,"text":"6. Minimally important difference (MID) and clinical definitions: To determine MIDs and","text_display":"\n6. Minimally important difference (MID) and clinical definitions: To determine MIDs and","confidence":1,"confidence_rate":1},{"cnt":[[271,829],[1972,829],[1972,874],[271,874]],"region":{"top_left_x":270,"top_left_y":829,"width":1703,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85ca96234bf14eb1a69b98401ebdf0af","type":"text","conversion_output":true,"text":"clinically meaningful definitions of MUI that predict clinical outcomes using cut-offs and combinations","text_display":" clinically meaningful definitions of MUI that predict clinical outcomes using cut-offs and combinations","confidence":1,"confidence_rate":1},{"cnt":[[271,872],[715,872],[715,913],[271,913]],"region":{"top_left_x":270,"top_left_y":872,"width":446,"height":42},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17f9a126612540afa977358b41496454","type":"text","conversion_output":true,"text":"of standardized measures","text_display":" of standardized measures","confidence":1,"confidence_rate":1},{"cnt":[[271,962],[1955,962],[1955,1008],[271,1008]],"region":{"top_left_x":270,"top_left_y":962,"width":1686,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2cdfe432f2fc4eaf956a5044c3bc5dff","type":"text","conversion_output":true,"text":"7. Pelvic floor muscle strengthening: To compare pelvic floor muscle strength changes between","text_display":"\n7. Pelvic floor muscle strengthening: To compare pelvic floor muscle strength changes between","confidence":1,"confidence_rate":1},{"cnt":[[271,1005],[1858,1005],[1858,1046],[271,1046]],"region":{"top_left_x":270,"top_left_y":1005,"width":1589,"height":42},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9fef2ba7bc84fd2be01f35d9c776d5f","type":"text","conversion_output":true,"text":"women randomized to combined MUS+BPTx versus MUS alone and to estimate associations","text_display":" women randomized to combined MUS+BPTx versus MUS alone and to estimate associations","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[271,1048],[1972,1048],[1972,1094],[271,1094]],"region":{"top_left_x":270,"top_left_y":1048,"width":1703,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed0c907d478b4983834837785bae5b88","type":"text","conversion_output":true,"text":"between pelvic floor muscle strength improvement and UI symptoms. We will also explore predictors","text_display":" between pelvic floor muscle strength improvement and UI symptoms. We will also explore predictors","confidence":1,"confidence_rate":1},{"cnt":[[271,1094],[1119,1094],[1119,1137],[271,1137]],"region":{"top_left_x":270,"top_left_y":1093,"width":850,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6383ac090e02463fa48b68e728484a88","type":"text","conversion_output":true,"text":"of unsuccessful pelvic floor muscle strengthening.","text_display":" of unsuccessful pelvic floor muscle strengthening.","confidence":1,"confidence_rate":1},{"cnt":[[271,1182],[1957,1182],[1957,1227],[271,1227]],"region":{"top_left_x":270,"top_left_y":1181,"width":1688,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b00366c40454992a8664ac7b4a9d017","type":"text","conversion_output":true,"text":"8. Cost-effectiveness analysis: To determine the cost effectiveness of combined midurethral sling","text_display":"\n8. Cost-effectiveness analysis: To determine the cost effectiveness of combined midurethral sling","confidence":1,"confidence_rate":1},{"cnt":[[271,1225],[1897,1225],[1897,1270],[271,1270]],"region":{"top_left_x":270,"top_left_y":1224,"width":1628,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3922d5f7fd1e4d5a8723707abb8089eb","type":"text","conversion_output":true,"text":"(MUS) and peri-operative behavioral/pelvic floor therapy (BPTx) compared to MUS alone for the","text_display":" (MUS) and peri-operative behavioral/pelvic floor therapy (BPTx) compared to MUS alone for the","confidence":1,"confidence_rate":1},{"cnt":[[271,1268],[748,1268],[748,1313],[271,1313]],"region":{"top_left_x":270,"top_left_y":1267,"width":478,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77a1ff8b517d4f26839c68cfa5cd9b88","type":"text","conversion_output":true,"text":"treatment of MUI symptoms","text_display":" treatment of MUI symptoms","confidence":1,"confidence_rate":1},{"cnt":[[142,1351],[1308,1351],[1308,1396],[142,1396]],"region":{"top_left_x":141,"top_left_y":1351,"width":1168,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6c7ec50b2934599a8b58797b285c0ff","type":"section_header","conversion_output":false,"children_ids":["7d1ca12cc9f5409e851cee049444c53a"],"text":"","text_display":""},{"cnt":[[146,1354],[1304,1354],[1304,1394],[146,1394]],"region":{"top_left_x":146,"top_left_y":1353,"width":1159,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d1ca12cc9f5409e851cee049444c53a","type":"text","conversion_output":true,"parent_id":"b6c7ec50b2934599a8b58797b285c0ff","text":"2. BACKGROUND INFORMATION AND SCIENTIFIC RATIONALE","text_display":"\n\n\\section*{2. BACKGROUND INFORMATION AND SCIENTIFIC RATIONALE}","confidence":1,"confidence_rate":1},{"cnt":[[142,1435],[767,1435],[767,1489],[142,1489]],"region":{"top_left_x":141,"top_left_y":1435,"width":626,"height":54},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8139c819402d44c4948ad1663573a5eb","type":"section_header","conversion_output":false,"children_ids":["bf360aa0525545ceb8e2848bfea40642"],"text":"","text_display":""},{"cnt":[[146,1439],[763,1439],[763,1485],[146,1485]],"region":{"top_left_x":146,"top_left_y":1439,"width":617,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf360aa0525545ceb8e2848bfea40642","type":"text","conversion_output":true,"parent_id":"8139c819402d44c4948ad1663573a5eb","text":"2.1. Disease/Condition Background:","text_display":"\n\n\\subsection*{2.1. Disease/Condition Background:}","confidence":1,"confidence_rate":1},{"cnt":[[271,1495],[1962,1495],[1962,1540],[271,1540]],"region":{"top_left_x":270,"top_left_y":1495,"width":1692,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a5cf3132b844090a8e9de79cecbf320","type":"text","conversion_output":true,"text":"Up to \\(50 \\%\\) of women with incontinence have mixed urinary incontinence (MUI); a complex condition","text_display":"\n\nUp to \\(50 \\%\\) of women with incontinence have mixed urinary incontinence (MUI); a complex condition","confidence":0.9331378936767578,"confidence_rate":0.9993283587292638},{"cnt":[[146,1538],[1927,1538],[1927,1583],[146,1583]],"region":{"top_left_x":146,"top_left_y":1538,"width":1782,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17a7383d0ee74e459f32f07e9d04e077","type":"text","conversion_output":true,"text":"that is significantly challenging for patients, clinicians and researchers. \\({ }^{4-6}\\) For patients, the combination of","text_display":" that is significantly challenging for patients, clinicians and researchers. \\({ }^{4-6}\\) For patients, the combination of","confidence":1,"confidence_rate":1},{"cnt":[[146,1581],[1936,1581],[1936,1626],[146,1626]],"region":{"top_left_x":146,"top_left_y":1581,"width":1790,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90a5208bc3404aae8418f5f60c769804","type":"text","conversion_output":true,"text":"UUI and SUI is more bothersome compared to either condition alone. \\({ }^{7-9}\\) For clinicians, treatment of MUI is","text_display":" UUI and SUI is more bothersome compared to either condition alone. \\({ }^{7-9}\\) For clinicians, treatment of MUI is","confidence":0.9975595474243164,"confidence_rate":0.9999798065234454},{"cnt":[[146,1626],[1867,1626],[1867,1669],[146,1669]],"region":{"top_left_x":146,"top_left_y":1626,"width":1721,"height":44},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09eb906bd6884847969c1cfa86e1c354","type":"text","conversion_output":true,"text":"challenging due to higher failure rates, as interventions designed to benefit one symptom often do not","text_display":" challenging due to higher failure rates, as interventions designed to benefit one symptom often do not","confidence":1,"confidence_rate":1},{"cnt":[[146,1669],[1906,1669],[1906,1714],[146,1714]],"region":{"top_left_x":146,"top_left_y":1669,"width":1760,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a57e33ea82be4026b2034b0c6f0b809e","type":"text","conversion_output":true,"text":"benefit the other. For clinicians and researchers, the lack of a clinically useful definition of MUI \\({ }^{10}\\) and the","text_display":" benefit the other. For clinicians and researchers, the lack of a clinically useful definition of MUI \\({ }^{10}\\) and the","confidence":0.99462890625,"confidence_rate":0.9999572582949401},{"cnt":[[146,1714],[1955,1714],[1955,1760],[146,1760]],"region":{"top_left_x":146,"top_left_y":1714,"width":1810,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e87107aead14b0e98bc3d287f8f1726","type":"text","conversion_output":true,"text":"frequent exclusion of MUI patients from randomized trials \\({ }^{11}\\) pose challenges for determining best treatment","text_display":" frequent exclusion of MUI patients from randomized trials \\({ }^{11}\\) pose challenges for determining best treatment","confidence":1,"confidence_rate":1},{"cnt":[[146,1757],[1953,1757],[1953,1803],[146,1803]],"region":{"top_left_x":146,"top_left_y":1757,"width":1807,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6edad8eac4bf4f6892d559472d96d3a7","type":"text","conversion_output":true,"text":"approaches. The wide variability of patient symptoms and terminology, ranging from \"stress-predominant\",","text_display":" approaches. The wide variability of patient symptoms and terminology, ranging from \"stress-predominant\",","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[146,1800],[1781,1800],[1781,1846],[146,1846]],"region":{"top_left_x":146,"top_left_y":1800,"width":1636,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10108af6d52e49219a64cb02fa5099df","type":"text","conversion_output":true,"text":"\"urge-predominant\", \"OAB -wet\" or \"OAB-dry\", further complicates data interpretation and patient","text_display":" \"urge-predominant\", \"OAB -wet\" or \"OAB-dry\", further complicates data interpretation and patient","confidence":1,"confidence_rate":1},{"cnt":[[146,1848],[1944,1848],[1944,1893],[146,1893]],"region":{"top_left_x":146,"top_left_y":1847,"width":1799,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11e41e44c7fd4ddcbf0605c92a6d36f0","type":"text","conversion_output":true,"text":"management. The current definitions and treatment approaches have failed to provide significant progress","text_display":" management. The current definitions and treatment approaches have failed to provide significant progress","confidence":1,"confidence_rate":1},{"cnt":[[146,1891],[917,1891],[917,1931],[146,1931]],"region":{"top_left_x":146,"top_left_y":1890,"width":772,"height":42},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe0bb2e03bd444d79798a95e9bf0bf11","type":"text","conversion_output":true,"text":"in the treatment of this bothersome condition.","text_display":" in the treatment of this bothersome condition.","confidence":1,"confidence_rate":1},{"cnt":[[301,1946],[1094,1946],[1094,2305],[301,2305]],"region":{"top_left_x":300,"top_left_y":1946,"width":794,"height":360},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7ed9d2452144846a7d4f89d7e5fefbd","type":"diagram","conversion_output":true,"selected_labels":["706c9e7ca76141f9a3a8b1ae07308010"],"text":"","text_display":"\n\n\\begin{figure}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/722dd686-9d24-4967-a9cf-6968feb8114e-08.jpg?height=360&width=794&top_left_y=1946&top_left_x=300}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 1. Conceptual model of MUI. Adapted from Katsumi et al \\({ }^{1}\\)}\n\\end{figure}"},{"cnt":[[1106,2363],[1962,2363],[1962,2454],[1106,2454]],"region":{"top_left_x":1106,"top_left_y":2363,"width":856,"height":91},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"706c9e7ca76141f9a3a8b1ae07308010","type":"figure_label","conversion_output":false,"children_ids":["964a6ed2257449ebbd006323fef77c7a","fa6e07b7d1174a2689a4328b8c7d1b04"],"text":"","text_display":""},{"cnt":[[1109,2368],[1957,2368],[1957,2413],[1109,2413]],"region":{"top_left_x":1108,"top_left_y":2367,"width":850,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"964a6ed2257449ebbd006323fef77c7a","type":"text","conversion_output":false,"parent_id":"706c9e7ca76141f9a3a8b1ae07308010","text":"Figure 1. Conceptual model of MUI. Adapted from","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1109,2411],[1347,2411],[1347,2449],[1109,2449]],"region":{"top_left_x":1108,"top_left_y":2410,"width":240,"height":40},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa6e07b7d1174a2689a4328b8c7d1b04","type":"text","conversion_output":false,"parent_id":"706c9e7ca76141f9a3a8b1ae07308010","text":"Katsumi et al \\({ }^{1}\\)","text_display":"","confidence":0.9258878231048584,"confidence_rate":0.997042758469701},{"cnt":[[1048,2548],[1074,2548],[1074,2593],[1048,2593]],"region":{"top_left_x":1048,"top_left_y":2548,"width":27,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c0729f7d160498c8b0f02f073ad55ab","type":"page_info","conversion_output":false,"text":"8","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e02736c824c24cd8864a1cba9cc76caf","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-09","page":9,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f4193f2cdeb4f239d07ba09103e1b55","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f99096d1b4ee41569acacc8ebe4e7d24","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f2fda209e2d45558080b7bd94b0ce75","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,254],[146,254]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":40},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41e1f6082a5a4514bba62d1e3cfca76d","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,258],[681,258],[681,305],[146,305]],"region":{"top_left_x":146,"top_left_y":257,"width":536,"height":49},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9584b47fe605472c8be4ebdf061cbdf1","type":"section_header","conversion_output":false,"children_ids":["61b12fb67ee84cd49668eca6d4033f8e"],"text":"","text_display":""},{"cnt":[[146,262],[681,262],[681,303],[146,303]],"region":{"top_left_x":146,"top_left_y":262,"width":536,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61b12fb67ee84cd49668eca6d4033f8e","type":"text","conversion_output":true,"parent_id":"9584b47fe605472c8be4ebdf061cbdf1","text":"2.2. Challenges with definitions","text_display":"\n\n\\subsection*{2.2. Challenges with definitions}","confidence":0.9853515625,"confidence_rate":0.9996012474892516},{"cnt":[[271,314],[1974,314],[1974,359],[271,359]],"region":{"top_left_x":270,"top_left_y":313,"width":1705,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf89b28989c94ee8b70a3e0ad0b568ab","type":"text","conversion_output":true,"text":"There is significant variability and controversy regarding the \"best\" definition of MUI: essentially there","text_display":"\n\nThere is significant variability and controversy regarding the \"best\" definition of MUI: essentially there","confidence":1,"confidence_rate":1},{"cnt":[[146,357],[1927,357],[1927,397],[146,397]],"region":{"top_left_x":146,"top_left_y":356,"width":1782,"height":42},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d755071f5f7247bbb64393a0526b7a3a","type":"text","conversion_output":true,"text":"is an absence of a universal definition. \\({ }^{10-15}\\) Based on the name alone, it makes sense that \"MUI\" includes","text_display":" is an absence of a universal definition. \\({ }^{10-15}\\) Based on the name alone, it makes sense that \"MUI\" includes","confidence":1,"confidence_rate":1},{"cnt":[[146,400],[1936,400],[1936,445],[146,445]],"region":{"top_left_x":146,"top_left_y":399,"width":1790,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bf9743935cb4afbaeffa767b2640860","type":"text","conversion_output":true,"text":"symptoms of both SUI and UUI/OAB. The International Urogynecological Association (IUGA)/International","text_display":" symptoms of both SUI and UUI/OAB. The International Urogynecological Association (IUGA)/International","confidence":1,"confidence_rate":1},{"cnt":[[146,445],[1951,445],[1951,488],[146,488]],"region":{"top_left_x":146,"top_left_y":444,"width":1805,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bbcbc5a4a444619a2072293435fa532","type":"text","conversion_output":true,"text":"Continence Society (ICS) joint terminology report defines OAB based on symptoms alone as \"urgency with","text_display":" Continence Society (ICS) joint terminology report defines OAB based on symptoms alone as \"urgency with","confidence":1,"confidence_rate":1},{"cnt":[[146,490],[1940,490],[1940,535],[146,535]],"region":{"top_left_x":146,"top_left_y":489,"width":1795,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34c6d4a1c9404e4a85d36be4d5d2c78e","type":"text","conversion_output":true,"text":"or without urgency incontinence, usually with frequency and nocturia\": women can be \"OAB-wet\" or \"OAB-","text_display":" or without urgency incontinence, usually with frequency and nocturia\": women can be \"OAB-wet\" or \"OAB","confidence":1,"confidence_rate":1},{"cnt":[[146,533],[1923,533],[1923,578],[146,578]],"region":{"top_left_x":146,"top_left_y":532,"width":1777,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4125d648cbb54824b07e98d3dd0420ae","type":"text","conversion_output":true,"text":"dry\". MUI is defined by the same group as \"the complaint of involuntary leakage associated with urgency","text_display":"dry\". MUI is defined by the same group as \"the complaint of involuntary leakage associated with urgency","confidence":1,"confidence_rate":1},{"cnt":[[146,576],[1934,576],[1934,621],[146,621]],"region":{"top_left_x":146,"top_left_y":575,"width":1788,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5541125142b64b8283e3dbe09f0b5b14","type":"text","conversion_output":true,"text":"and also with exertion, effort, sneezing, or coughing\". \\({ }^{16}\\) Clinical challenges with this definition include: 1) it","text_display":" and also with exertion, effort, sneezing, or coughing\". \\({ }^{16}\\) Clinical challenges with this definition include: 1) it","confidence":0.9970715045928955,"confidence_rate":0.9999772654379698},{"cnt":[[146,623],[1906,623],[1906,664],[146,664]],"region":{"top_left_x":146,"top_left_y":623,"width":1760,"height":41},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7e16cb4090c4ff38b12ebded898ed90","type":"text","conversion_output":true,"text":"excludes women who may have significant urgency and/or frequency without UUI; 2 ) it excludes women","text_display":" excludes women who may have significant urgency and/or frequency without UUI; 2 ) it excludes women","confidence":0.6113308388739824,"confidence_rate":0.9954113359818213},{"cnt":[[146,666],[1944,666],[1944,711],[146,711]],"region":{"top_left_x":146,"top_left_y":666,"width":1799,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ec77f536fdb4d5abe8a288f9b27bd1c","type":"text","conversion_output":true,"text":"who have detrusor overactivity in the absence of sensory urgency; and 3) many women do not experience","text_display":" who have detrusor overactivity in the absence of sensory urgency; and 3) many women do not experience","confidence":0.7682049149880186,"confidence_rate":0.9975153676230216},{"cnt":[[146,709],[1803,709],[1803,754],[146,754]],"region":{"top_left_x":146,"top_left_y":708,"width":1657,"height":47},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb629d7278154380a32304d5761998be","type":"text","conversion_output":true,"text":"SUI or UUI based on these clear cut definitions. Purely \"objective\" measures such as urodynamic","text_display":" SUI or UUI based on these clear cut definitions. Purely \"objective\" measures such as urodynamic","confidence":1,"confidence_rate":1},{"cnt":[[146,752],[1955,752],[1955,797],[146,797]],"region":{"top_left_x":146,"top_left_y":751,"width":1810,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e45f612e1ea4d3a85b67b4eceae0dd0","type":"text","conversion_output":true,"text":"evaluation (UDE) also do not provide a clear and consistent definition. Further complicating the issue is the","text_display":" evaluation (UDE) also do not provide a clear and consistent definition. Further complicating the issue is the","confidence":1,"confidence_rate":1},{"cnt":[[146,795],[1837,795],[1837,840],[146,840]],"region":{"top_left_x":146,"top_left_y":794,"width":1691,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d297a56b0cbf41eeb2ae49663bd8d970","type":"text","conversion_output":true,"text":"lack of consensus and evidence regarding the pathophysiology of MUI. Some experts argue the two","text_display":" lack of consensus and evidence regarding the pathophysiology of MUI. Some experts argue the two","confidence":1,"confidence_rate":1},{"cnt":[[146,838],[1923,838],[1923,887],[146,887]],"region":{"top_left_x":146,"top_left_y":837,"width":1777,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c2a0e714ca1470a9cee7eeb3285cf5b","type":"text","conversion_output":true,"text":"conditions should be considered as having completely different pathological processes, \\({ }^{12}\\) whereas others","text_display":" conditions should be considered as having completely different pathological processes, \\({ }^{12}\\) whereas others","confidence":1,"confidence_rate":1},{"cnt":[[146,885],[1919,885],[1919,930],[146,930]],"region":{"top_left_x":146,"top_left_y":885,"width":1773,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f23f662168ba42b7b1f83446f8fc5e9b","type":"text","conversion_output":true,"text":"argue that at least in a subset of women, they are directly linked (e.g. proximal urethral funneling causing","text_display":" argue that at least in a subset of women, they are directly linked (e.g. proximal urethral funneling causing","confidence":1,"confidence_rate":1},{"cnt":[[146,928],[518,928],[518,973],[146,973]],"region":{"top_left_x":146,"top_left_y":928,"width":372,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a98bb51e1ab844f89de907f818bd841d","type":"text","conversion_output":true,"text":"detrusor overactivity).","text_display":" detrusor overactivity).","confidence":1,"confidence_rate":1},{"cnt":[[271,971],[1893,971],[1893,1016],[271,1016]],"region":{"top_left_x":270,"top_left_y":971,"width":1623,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a3bada276724171b00500540fc5f1dd","type":"text","conversion_output":true,"text":"Brubaker et al and the Urinary Incontinence Treatment Network (UITN) attempted to develop an","text_display":"\n\nBrubaker et al and the Urinary Incontinence Treatment Network (UITN) attempted to develop an","confidence":1,"confidence_rate":1},{"cnt":[[146,1014],[1953,1014],[1953,1059],[146,1059]],"region":{"top_left_x":146,"top_left_y":1014,"width":1807,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5d9bdc559644f3aa4662b0951aae31a","type":"text","conversion_output":true,"text":"empirically derived definition of MUI in \\(2009 .{ }^{10}\\) Using data from the Stress Incontinence Surgical Treatment","text_display":" empirically derived definition of MUI in \\(2009 .{ }^{10}\\) Using data from the Stress Incontinence Surgical Treatment","confidence":0.7721473017420522,"confidence_rate":0.9978827368507969},{"cnt":[[146,1057],[1876,1057],[1876,1104],[146,1104]],"region":{"top_left_x":146,"top_left_y":1057,"width":1730,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41d71a0542f64f2d9f1168afc3f3c35e","type":"text","conversion_output":true,"text":"Efficacy Trial (SISTEr trial), a randomized trial comparing fascial sling to Burch colposuspension, \\({ }^{17}\\) the","text_display":" Efficacy Trial (SISTEr trial), a randomized trial comparing fascial sling to Burch colposuspension, \\({ }^{17}\\) the","confidence":0.99951171875,"confidence_rate":0.9999959636403931},{"cnt":[[146,1104],[1760,1104],[1760,1149],[146,1149]],"region":{"top_left_x":146,"top_left_y":1104,"width":1614,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d86d4cf639614bfe8d36103779c951ca","type":"text","conversion_output":true,"text":"investigators used a series of regressions and attempted to define cut-off values for a variety of","text_display":" investigators used a series of regressions and attempted to define cut-off values for a variety of","confidence":1,"confidence_rate":1},{"cnt":[[146,1147],[1944,1147],[1944,1192],[146,1192]],"region":{"top_left_x":146,"top_left_y":1147,"width":1799,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6b375cf7fef489da483dca9dd4f439d","type":"text","conversion_output":true,"text":"standardized measures that could predict clinical outcomes. Standardized measures included the Medical,","text_display":" standardized measures that could predict clinical outcomes. Standardized measures included the Medical,","confidence":1,"confidence_rate":1},{"cnt":[[146,1190],[1957,1190],[1957,1238],[146,1238]],"region":{"top_left_x":146,"top_left_y":1190,"width":1812,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69af93ba02a44ba39ce049f0716fde6e","type":"text","conversion_output":true,"text":"Epidemiologic and Social Aspects of Aging (MESA), \\({ }^{18}\\) the Urogenital Distress Inventory (UDI), \\({ }^{2}\\) urodynamic","text_display":" Epidemiologic and Social Aspects of Aging (MESA), \\({ }^{18}\\) the Urogenital Distress Inventory (UDI), \\({ }^{2}\\) urodynamic","confidence":1,"confidence_rate":1},{"cnt":[[146,1235],[1912,1235],[1912,1283],[146,1283]],"region":{"top_left_x":146,"top_left_y":1235,"width":1767,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2af0a96a0de847828756c7254171eae7","type":"text","conversion_output":true,"text":"studies and a 3 -day urinary diary. The investigators created threshold definitions using the MESA (which","text_display":" studies and a 3 -day urinary diary. The investigators created threshold definitions using the MESA (which","confidence":0.79052734375,"confidence_rate":0.9979220289465742},{"cnt":[[146,1280],[1936,1280],[1936,1326],[146,1326]],"region":{"top_left_x":146,"top_left_y":1280,"width":1790,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db172efd19ca46d4bc38dea59ba33851","type":"text","conversion_output":true,"text":"measures the frequency of SUI and/or UUI), the UDI (which measures the presence and degree of bother","text_display":" measures the frequency of SUI and/or UUI), the UDI (which measures the presence and degree of bother","confidence":1,"confidence_rate":1},{"cnt":[[146,1323],[1854,1323],[1854,1369],[146,1369]],"region":{"top_left_x":146,"top_left_y":1323,"width":1709,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7178ce47c32e412c95a432d48bfc96e3","type":"text","conversion_output":true,"text":"for SUI and UUI), and UDE (defined as presence of urodynamic SUI and detrusor overactivity with or","text_display":" for SUI and UUI), and UDE (defined as presence of urodynamic SUI and detrusor overactivity with or","confidence":1,"confidence_rate":1},{"cnt":[[146,1366],[1826,1366],[1826,1412],[146,1412]],"region":{"top_left_x":146,"top_left_y":1366,"width":1681,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9e9850fc0b946bda4386499b6019e6b","type":"text","conversion_output":true,"text":"without associated leakage). These definitions were evaluated against the trial's clinical outcome, a","text_display":" without associated leakage). These definitions were evaluated against the trial's clinical outcome, a","confidence":0.99755859375,"confidence_rate":0.9999769399702094},{"cnt":[[146,1412],[1974,1412],[1974,1454],[146,1454]],"region":{"top_left_x":146,"top_left_y":1411,"width":1829,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a60a9939396b48199c1040d3dc330d5b","type":"text","conversion_output":true,"text":"composite outcome divided into SUI success (negative cough stress test, no SUI re-treatment, and negative","text_display":" composite outcome divided into SUI success (negative cough stress test, no SUI re-treatment, and negative","confidence":1,"confidence_rate":1},{"cnt":[[146,1454],[1850,1454],[1850,1500],[146,1500]],"region":{"top_left_x":146,"top_left_y":1454,"width":1704,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5c08cb6bc0f47ee8e6439b49c5375f2","type":"text","conversion_output":true,"text":"MESA SUI) and overall success (stress criteria plus no leakage on diary or pad test). After testing 12","text_display":" MESA SUI) and overall success (stress criteria plus no leakage on diary or pad test). After testing 12","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[146,1500],[1886,1500],[1886,1545],[146,1545]],"region":{"top_left_x":146,"top_left_y":1499,"width":1741,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db83c340e09341a3a8df809396654d25","type":"text","conversion_output":true,"text":"different definitions for MUI, the authors were unable to identify a definition that could accurately reflect","text_display":" different definitions for MUI, the authors were unable to identify a definition that could accurately reflect","confidence":1,"confidence_rate":1},{"cnt":[[146,1543],[1944,1543],[1944,1588],[146,1588]],"region":{"top_left_x":146,"top_left_y":1542,"width":1799,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f28f2db05de4191bb9aa617b2a5b452","type":"text","conversion_output":true,"text":"clinical outcomes and proposed that both subcomponents of SUI and UUI should be individually described","text_display":" clinical outcomes and proposed that both subcomponents of SUI and UUI should be individually described","confidence":1,"confidence_rate":1},{"cnt":[[146,1586],[1927,1586],[1927,1631],[146,1631]],"region":{"top_left_x":146,"top_left_y":1585,"width":1782,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6ee82dd82d54bffb604900c15dfb3f9","type":"text","conversion_output":true,"text":"instead of using a one-dimensional descriptor. One limitation is that the SISTEr trial included only women","text_display":" instead of using a one-dimensional descriptor. One limitation is that the SISTEr trial included only women","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[146,1629],[853,1629],[853,1674],[146,1674]],"region":{"top_left_x":146,"top_left_y":1628,"width":707,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c16f9cac6a9434ab13a52c7ab37b9de","type":"text","conversion_output":true,"text":"with pure SUI or stress-predominant MUI.","text_display":" with pure SUI or stress-predominant MUI.","confidence":1,"confidence_rate":1},{"cnt":[[271,1676],[1966,1676],[1966,1721],[271,1721]],"region":{"top_left_x":270,"top_left_y":1675,"width":1696,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4464c43b80fb42429bbe526d6b5d4e78","type":"text","conversion_output":true,"text":"In a second attempt, Brubaker et al used data from the UITN Behavior Enhances Drug Reduction of","text_display":"\n\nIn a second attempt, Brubaker et al used data from the UITN Behavior Enhances Drug Reduction of","confidence":1,"confidence_rate":1},{"cnt":[[146,1719],[1830,1719],[1830,1764],[146,1764]],"region":{"top_left_x":146,"top_left_y":1718,"width":1685,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1295fae324334d23965ca167a486a322","type":"text","conversion_output":true,"text":"Incontinence (BE-DRI) to again explore operational definitions of MUI, using various thresholds and","text_display":" Incontinence (BE-DRI) to again explore operational definitions of MUI, using various thresholds and","confidence":1,"confidence_rate":1},{"cnt":[[146,1762],[1949,1762],[1949,1807],[146,1807]],"region":{"top_left_x":146,"top_left_y":1761,"width":1803,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd8f9328e8ef48228bf610d7a8d25136","type":"text","conversion_output":true,"text":"combinations of the MESA, UDI and 7 -day voiding diary. \\({ }^{19}\\) They were unable to identify strict cut-off values","text_display":" combinations of the MESA, UDI and 7 -day voiding diary. \\({ }^{19}\\) They were unable to identify strict cut-off values","confidence":0.9423828125,"confidence_rate":0.9995328358932548},{"cnt":[[146,1805],[1919,1805],[1919,1850],[146,1850]],"region":{"top_left_x":146,"top_left_y":1804,"width":1773,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ad48a732d5a48ec9eaf80325442535a","type":"text","conversion_output":true,"text":"for any of these baseline measures that could predict the study's primary outcome (success defined as a","text_display":" for any of these baseline measures that could predict the study's primary outcome (success defined as a","confidence":1,"confidence_rate":1},{"cnt":[[146,1850],[1927,1850],[1927,1897],[146,1897]],"region":{"top_left_x":146,"top_left_y":1849,"width":1782,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fe5dcf1947843f8a502a2e535892165","type":"text","conversion_output":true,"text":"\\(70 \\%\\) reduction in incontinence episodes). Because of this, the authors again recommended using distinct","text_display":" \\(70 \\%\\) reduction in incontinence episodes). Because of this, the authors again recommended using distinct","confidence":1,"confidence_rate":1},{"cnt":[[146,1895],[1949,1895],[1949,1940],[146,1940]],"region":{"top_left_x":146,"top_left_y":1894,"width":1803,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c074d7485aa44e50a2a4574f92a27b8a","type":"text","conversion_output":true,"text":"descriptions of both urgency and stress subcomponents when characterizing subjects with MUI until better","text_display":" descriptions of both urgency and stress subcomponents when characterizing subjects with MUI until better","confidence":1,"confidence_rate":1},{"cnt":[[146,1938],[1955,1938],[1955,1983],[146,1983]],"region":{"top_left_x":146,"top_left_y":1937,"width":1810,"height":47},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2e658e87f44413888ef044f7ed9db16","type":"text","conversion_output":true,"text":"definitions are developed. One limitation is that the BE-DRI population included primarily women with urge-","text_display":" definitions are developed. One limitation is that the BE-DRI population included primarily women with urge","confidence":1,"confidence_rate":1},{"cnt":[[146,1981],[453,1981],[453,2026],[146,2026]],"region":{"top_left_x":146,"top_left_y":1980,"width":308,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8f171fe6db4487ab379fef735c44fbf","type":"text","conversion_output":true,"text":"predominant MUI.","text_display":"predominant MUI.","confidence":1,"confidence_rate":1},{"cnt":[[142,2110],[1416,2110],[1416,2159],[142,2159]],"region":{"top_left_x":141,"top_left_y":2109,"width":1275,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b08466d69be74da497e089395ebb8181","type":"section_header","conversion_output":false,"children_ids":["f3f9696a03474feebd4e27fd3f99030a"],"text":"","text_display":""},{"cnt":[[146,2114],[1412,2114],[1412,2155],[146,2155]],"region":{"top_left_x":146,"top_left_y":2114,"width":1266,"height":41},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3f9696a03474feebd4e27fd3f99030a","type":"text","conversion_output":true,"parent_id":"b08466d69be74da497e089395ebb8181","text":"2.3. Current treatment strategies for MUI: Challenges and old assumptions","text_display":"\n\n\\subsection*{2.3. Current treatment strategies for MUI: Challenges and old assumptions}","confidence":0.99853515625,"confidence_rate":0.9999812063601604},{"cnt":[[271,2166],[1962,2166],[1962,2211],[271,2211]],"region":{"top_left_x":270,"top_left_y":2165,"width":1692,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94bfcb30f875432883b592f660ca36e6","type":"text","conversion_output":true,"text":"Based on expert opinion, the primary treatment strategy for MUI typically begins with segregation of","text_display":"\n\nBased on expert opinion, the primary treatment strategy for MUI typically begins with segregation of","confidence":1,"confidence_rate":1},{"cnt":[[146,2211],[1940,2211],[1940,2254],[146,2254]],"region":{"top_left_x":146,"top_left_y":2210,"width":1795,"height":44},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c01735a28367426cbf0d5d869245a085","type":"text","conversion_output":true,"text":"symptoms and focus on the most bothersome symptom (SUI vs UUI). Although many women may clearly","text_display":" symptoms and focus on the most bothersome symptom (SUI vs UUI). Although many women may clearly","confidence":1,"confidence_rate":1},{"cnt":[[146,2256],[1815,2256],[1815,2297],[146,2297]],"region":{"top_left_x":146,"top_left_y":2255,"width":1670,"height":42},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"623971880fa84fbf8b783f3064694795","type":"text","conversion_output":true,"text":"have one condition that is more bothersome, many have equally bothersome symptoms, or cannot","text_display":" have one condition that is more bothersome, many have equally bothersome symptoms, or cannot","confidence":1,"confidence_rate":1},{"cnt":[[146,2299],[1957,2299],[1957,2344],[146,2344]],"region":{"top_left_x":146,"top_left_y":2298,"width":1812,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82bd3a6a422d4418ae4896a8400a4320","type":"text","conversion_output":true,"text":"determine which condition is \"most bothersome\". Behavioral/pelvic floor therapy (BPTx) has been shown to","text_display":" determine which condition is \"most bothersome\". Behavioral/pelvic floor therapy (BPTx) has been shown to","confidence":1,"confidence_rate":1},{"cnt":[[146,2340],[1811,2340],[1811,2387],[146,2387]],"region":{"top_left_x":146,"top_left_y":2339,"width":1666,"height":48},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3668fd02f95452c9d5b90365b0fe872","type":"text","conversion_output":true,"text":"be effective for all types of incontinence \\({ }^{20}\\), and some experts suggest that BPTx should be the first","text_display":" be effective for all types of incontinence \\({ }^{20}\\), and some experts suggest that BPTx should be the first","confidence":1,"confidence_rate":1},{"cnt":[[146,2385],[1974,2385],[1974,2430],[146,2430]],"region":{"top_left_x":146,"top_left_y":2384,"width":1829,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5cf879b3215c40c4aa71f37eb22e26ea","type":"text","conversion_output":true,"text":"treatment for MUI, regardless of which symptom is more bothersome because it is minimally invasive. Other","text_display":" treatment for MUI, regardless of which symptom is more bothersome because it is minimally invasive. Other","confidence":1,"confidence_rate":1},{"cnt":[[146,2430],[1906,2430],[1906,2477],[146,2477]],"region":{"top_left_x":146,"top_left_y":2429,"width":1760,"height":49},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c79c598c68e24ed6aaa32023bd993b62","type":"text","conversion_output":true,"text":"authors support the first-line use of anti-muscarinics for MUI, despite that the improvement over placebo","text_display":" authors support the first-line use of anti-muscarinics for MUI, despite that the improvement over 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been shown to be only modest, \\({ }^{21}\\) side effects are common, and discontinuation is high, ranging from","text_display":" has been shown to be only modest, \\({ }^{21}\\) side effects are common, and discontinuation is high, ranging from","confidence":1,"confidence_rate":1},{"cnt":[[146,301],[1094,301],[1094,346],[146,346]],"region":{"top_left_x":146,"top_left_y":300,"width":948,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74b47aff4ec943c582e63326f8a46021","type":"text","conversion_output":true,"text":"\\(43 \\%-83 \\%\\) within the first 30 days of initial prescription. \\({ }^{22}\\)","text_display":" \\(43 \\%-83 \\%\\) within the first 30 days of initial prescription. \\({ }^{22}\\)","confidence":0.99853515625,"confidence_rate":0.9999799191374794},{"cnt":[[271,391],[1781,391],[1781,436],[271,436]],"region":{"top_left_x":270,"top_left_y":391,"width":1512,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7f2a60614544ff0bfc82048a6fd7d33","type":"text","conversion_output":true,"text":"Although intuitively it makes sense that non-surgical options should be offered first, these","text_display":"\n\nAlthough intuitively it makes sense that non-surgical options should be offered first, these","confidence":1,"confidence_rate":1},{"cnt":[[146,436],[1283,436],[1283,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1137,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"969a66c39f644a01995e10b2becb54cf","type":"text","conversion_output":true,"text":"recommendations are based on the following assumptions for MUI:","text_display":" recommendations are based on the following assumptions for MUI:","confidence":1,"confidence_rate":1},{"cnt":[[275,477],[1205,477],[1205,522],[275,522]],"region":{"top_left_x":275,"top_left_y":476,"width":931,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25c3ebec759549368f5240d8bce1e9fe","type":"text","conversion_output":true,"text":"1. OAB and SUI are separate and unrelated conditions","text_display":"\n1. OAB and SUI are separate and unrelated conditions","confidence":1,"confidence_rate":1},{"cnt":[[271,524],[1927,524],[1927,569],[271,569]],"region":{"top_left_x":270,"top_left_y":524,"width":1658,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a37dd42982e34e17bcca8cf31d9d7508","type":"text","conversion_output":true,"text":"-There is some evidence to suggest that at least in a subset of women, these 2 conditions may be","text_display":"\n-There is some evidence to suggest that at least in a subset of women, these 2 conditions may be","confidence":0.9951245749834925,"confidence_rate":0.9999530073669567},{"cnt":[[146,567],[1250,567],[1250,612],[146,612]],"region":{"top_left_x":146,"top_left_y":567,"width":1105,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fed1fef593a741528b45ab3e26a7f8e3","type":"text","conversion_output":true,"text":"related (proximal urethral funneling causing detrusor overactivity)","text_display":" related (proximal urethral funneling causing detrusor overactivity)","confidence":1,"confidence_rate":1},{"cnt":[[273,610],[1502,610],[1502,655],[273,655]],"region":{"top_left_x":272,"top_left_y":610,"width":1230,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7ccbb9991634267a8e0e87a49a34400","type":"text","conversion_output":true,"text":"2. Treatment should always be initiated in a stepwise, sequential fashion","text_display":"\n2. Treatment should always be initiated in a stepwise, sequential fashion","confidence":1,"confidence_rate":1},{"cnt":[[271,655],[1970,655],[1970,698],[271,698]],"region":{"top_left_x":270,"top_left_y":655,"width":1701,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34a370eb3cbf4a9b807f7724ba45ff69","type":"text","conversion_output":true,"text":"-There has been little evidence evaluating the potential benefit of combined treatments, and thus the","text_display":"\n-There has been little evidence evaluating the potential benefit of combined treatments, and thus the","confidence":1,"confidence_rate":1},{"cnt":[[146,698],[1222,698],[1222,741],[146,741]],"region":{"top_left_x":146,"top_left_y":698,"width":1077,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d137d9c8840b4acfaf624c7e0502b9e2","type":"text","conversion_output":true,"text":"old paradigm of following stepwise treatment remains unproven","text_display":" old paradigm of following stepwise treatment remains unproven","confidence":1,"confidence_rate":1},{"cnt":[[271,743],[1865,743],[1865,786],[271,786]],"region":{"top_left_x":270,"top_left_y":743,"width":1595,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dded36cbfd0490ca6b5e60dd84adb62","type":"text","conversion_output":true,"text":"3. Surgical treatment should be reserved for women with SUI-predominant MUI because it will","text_display":"\n3. Surgical treatment should be reserved for women with SUI-predominant MUI because it will","confidence":1,"confidence_rate":1},{"cnt":[[148,786],[552,786],[552,831],[148,831]],"region":{"top_left_x":148,"top_left_y":786,"width":405,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddde88913d1042c3a989d3b6d2336c0e","type":"text","conversion_output":true,"text":"worsen OAB symptoms","text_display":" worsen OAB symptoms","confidence":1,"confidence_rate":1},{"cnt":[[271,829],[1944,829],[1944,874],[271,874]],"region":{"top_left_x":270,"top_left_y":829,"width":1675,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b79cc76933dc44c3925f85b5474ee637","type":"text","conversion_output":true,"text":"-Most studies suggesting worsening of OAB symptoms included traditional bladder neck slings and","text_display":"\n-Most studies suggesting worsening of OAB symptoms included traditional bladder neck slings and","confidence":1,"confidence_rate":1},{"cnt":[[146,872],[672,872],[672,917],[146,917]],"region":{"top_left_x":146,"top_left_y":872,"width":527,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cc7e85557ce4dce9539d9f7a4e34bb8","type":"text","conversion_output":true,"text":"colposuspension and not MUS","text_display":" colposuspension and not MUS","confidence":1,"confidence_rate":1},{"cnt":[[271,920],[1897,920],[1897,965],[271,965]],"region":{"top_left_x":270,"top_left_y":919,"width":1628,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d47d74f4468d4f49955e9d74b71127dc","type":"text","conversion_output":true,"text":"4. All women would prefer to take long-term medications over undergoing a surgical intervention","text_display":"\n4. All women would prefer to take long-term medications over undergoing a surgical intervention","confidence":1,"confidence_rate":1},{"cnt":[[271,962],[917,962],[917,1008],[271,1008]],"region":{"top_left_x":270,"top_left_y":962,"width":648,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3cda8e520c244eb83de39ff21e60a8d","type":"text","conversion_output":true,"text":"-Adherence to anticholinergics is poor","text_display":" -Adherence to anticholinergics is poor","confidence":1,"confidence_rate":1},{"cnt":[[146,1051],[1968,1051],[1968,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1050,"width":1822,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aaa7c18028174609afc6ecf72c920d20","type":"text","conversion_output":true,"text":"Clinically, many women with MUI become dissatisfied with conservative treatment and/or the need to take a","text_display":"\n\nClinically, many women with MUI become dissatisfied with conservative treatment and/or the need to take a","confidence":1,"confidence_rate":1},{"cnt":[[146,1094],[1919,1094],[1919,1137],[146,1137]],"region":{"top_left_x":146,"top_left_y":1093,"width":1773,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45e2836c3f5c422d99182bc148fc3326","type":"text","conversion_output":true,"text":"medication long-term. In practice, there can be much \"cross-over\" due to patient dissatisfaction when the","text_display":" medication long-term. In practice, there can be much \"cross-over\" due to patient dissatisfaction when the","confidence":1,"confidence_rate":1},{"cnt":[[146,1139],[1944,1139],[1944,1182],[146,1182]],"region":{"top_left_x":146,"top_left_y":1138,"width":1799,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"106579ca4b9a43b8b19e5c59d13b5ec7","type":"text","conversion_output":true,"text":"outcomes of treatment are focused on only one symptom. Many women with \"urge-predominant\" MUI who","text_display":" outcomes of treatment are focused on only one symptom. Many women with \"urge-predominant\" MUI who","confidence":1,"confidence_rate":1},{"cnt":[[146,1182],[1828,1182],[1828,1227],[146,1227]],"region":{"top_left_x":146,"top_left_y":1181,"width":1683,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8623450d499040198514dbef4f56daf7","type":"text","conversion_output":true,"text":"have tried BPTx and/or anti-muscarinic therapy will go on to choose surgical treatment for SUI after","text_display":" have tried BPTx and/or anti-muscarinic therapy will go on to choose surgical treatment for SUI after","confidence":1,"confidence_rate":1},{"cnt":[[146,1225],[1818,1225],[1818,1270],[146,1270]],"region":{"top_left_x":146,"top_left_y":1224,"width":1672,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5cfe9c187af84be88e904ece8704e642","type":"text","conversion_output":true,"text":"becoming dissatisfied with the results. Women with equally bothersome OAB and SUI components","text_display":" becoming dissatisfied with the results. Women with equally bothersome OAB and SUI components","confidence":1,"confidence_rate":1},{"cnt":[[146,1268],[1970,1268],[1970,1313],[146,1313]],"region":{"top_left_x":146,"top_left_y":1267,"width":1825,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"418385a96eb34647b3a14196c244efd0","type":"text","conversion_output":true,"text":"commonly choose surgery, with or without a trial of BPTx. This \"traditional\" treatment paradigm for MUI has","text_display":" commonly choose surgery, with or without a trial of BPTx. This \"traditional\" treatment paradigm for MUI has","confidence":1,"confidence_rate":1},{"cnt":[[146,1315],[1837,1315],[1837,1360],[146,1360]],"region":{"top_left_x":146,"top_left_y":1314,"width":1691,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67756a30f2f5461c9be7a8440a33c3c2","type":"text","conversion_output":true,"text":"not resulted to significant advances and we are now challenged to consider new paradigms for MUI.","text_display":" not resulted to significant advances and we are now challenged to consider new paradigms for MUI.","confidence":1,"confidence_rate":1},{"cnt":[[142,1439],[1005,1439],[1005,1491],[142,1491]],"region":{"top_left_x":141,"top_left_y":1439,"width":865,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1446165982d34143ba75bf4c46c536f9","type":"section_header","conversion_output":false,"children_ids":["318ac71943064464a09d515638ebecde"],"text":"","text_display":""},{"cnt":[[146,1444],[1001,1444],[1001,1489],[146,1489]],"region":{"top_left_x":146,"top_left_y":1443,"width":856,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"318ac71943064464a09d515638ebecde","type":"text","conversion_output":true,"parent_id":"1446165982d34143ba75bf4c46c536f9","text":"2.4. Behavioral/pelvic floor muscle therapy (BPTx)","text_display":"\n\n\\subsection*{2.4. Behavioral/pelvic floor muscle therapy (BPTx)}","confidence":1,"confidence_rate":1},{"cnt":[[271,1497],[1871,1497],[1871,1540],[271,1540]],"region":{"top_left_x":270,"top_left_y":1497,"width":1602,"height":44},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce774e154faa4f4e9fee52f0261416cd","type":"text","conversion_output":true,"text":"BPTx includes components of behavioral therapy, designed to change behaviors to encourage","text_display":"\n\nBPTx includes components of behavioral therapy, designed to change behaviors to encourage","confidence":1,"confidence_rate":1},{"cnt":[[146,1543],[1934,1543],[1934,1586],[146,1586]],"region":{"top_left_x":146,"top_left_y":1542,"width":1788,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7703a8d06ca543aaaf1b84a9d46a7f1a","type":"text","conversion_output":true,"text":"continence, and pelvic floor muscle therapy, designed to strengthen the pelvic floor muscles, enhance the","text_display":" continence, and pelvic floor muscle therapy, designed to strengthen the pelvic floor muscles, enhance the","confidence":1,"confidence_rate":1},{"cnt":[[146,1586],[1901,1586],[1901,1631],[146,1631]],"region":{"top_left_x":146,"top_left_y":1585,"width":1756,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"514cc2bdcc4a457f87136b6405957f66","type":"text","conversion_output":true,"text":"physiological closure of the bladder neck, and improve coordination. A recent Cochrane review of pelvic","text_display":" physiological closure of the bladder neck, and improve coordination. A recent Cochrane review of pelvic","confidence":1,"confidence_rate":1},{"cnt":[[146,1629],[1970,1629],[1970,1674],[146,1674]],"region":{"top_left_x":146,"top_left_y":1628,"width":1825,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f41c64478484c089e04fde77faadd38","type":"text","conversion_output":true,"text":"floor muscle exercise found that these treatments were effective for both SUI and MUI compared to placebo","text_display":" floor muscle exercise found that these treatments were effective for both SUI and MUI compared to placebo","confidence":1,"confidence_rate":1},{"cnt":[[146,1671],[1949,1671],[1949,1717],[146,1717]],"region":{"top_left_x":146,"top_left_y":1671,"width":1803,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0aafa77eaf045c391c73644724353f7","type":"text","conversion_output":true,"text":"or no treatment, but women with pure SUI may have better outcomes. \\({ }^{20}\\) The UITN study BE-DRI by Burgio","text_display":" or no treatment, but women with pure SUI may have better outcomes. \\({ }^{20}\\) The UITN study BE-DRI by Burgio","confidence":1,"confidence_rate":1},{"cnt":[[146,1714],[1863,1714],[1863,1760],[146,1760]],"region":{"top_left_x":146,"top_left_y":1714,"width":1717,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a36b0e7c14b34e198e19d57e07f4f023","type":"text","conversion_output":true,"text":"et al evaluated whether combined anti-muscarinic therapy with behavioral therapy would increase the","text_display":" et al evaluated whether combined anti-muscarinic therapy with behavioral therapy would increase the","confidence":1,"confidence_rate":1},{"cnt":[[146,1760],[1962,1760],[1962,1807],[146,1807]],"region":{"top_left_x":146,"top_left_y":1759,"width":1816,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f862c3b3c356477ab02ead5f9977ce0f","type":"text","conversion_output":true,"text":"number of women who could discontinue drug therapy while sustaining a significant reduction in UUI. \\({ }^{23}\\) BE-","text_display":" number of women who could discontinue drug therapy while sustaining a significant reduction in UUI. \\({ }^{23}\\) BE","confidence":0.99951171875,"confidence_rate":0.9999959636403931},{"cnt":[[146,1805],[1923,1805],[1923,1850],[146,1850]],"region":{"top_left_x":146,"top_left_y":1804,"width":1777,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c07669008b2248f6a9c88bf71f198d06","type":"text","conversion_output":true,"text":"DRI included women with pure UUI or UUI-predominant MUI. Although the addition of behavioral therapy","text_display":"DRI included women with pure UUI or UUI-predominant MUI. Although the addition of behavioral therapy","confidence":1,"confidence_rate":1},{"cnt":[[146,1848],[1906,1848],[1906,1893],[146,1893]],"region":{"top_left_x":146,"top_left_y":1847,"width":1760,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51dfc9f0b6884df59acbc120f7d13def","type":"text","conversion_output":true,"text":"did not improve drug therapy discontinuation, the study found that the combination of behavioral training","text_display":" did not improve drug therapy discontinuation, the study found that the combination of behavioral training","confidence":1,"confidence_rate":1},{"cnt":[[146,1893],[1936,1893],[1936,1936],[146,1936]],"region":{"top_left_x":146,"top_left_y":1892,"width":1790,"height":44},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"056f8ff87e124a28a67b1e5699ea7cdd","type":"text","conversion_output":true,"text":"and drug therapy yielded improved urinary outcomes compared to drug therapy alone. Specific to the MUI","text_display":" and drug therapy yielded improved urinary outcomes compared to drug therapy alone. Specific to the MUI","confidence":1,"confidence_rate":1},{"cnt":[[146,1938],[1921,1938],[1921,1981],[146,1981]],"region":{"top_left_x":146,"top_left_y":1937,"width":1775,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0607e47b73254c13904436ddeba2965c","type":"text","conversion_output":true,"text":"population, there is a paucity of literature evaluating whether combined therapies including BPTx that are","text_display":" population, there is a paucity of literature evaluating whether combined therapies including BPTx that are","confidence":1,"confidence_rate":1},{"cnt":[[146,1981],[1921,1981],[1921,2026],[146,2026]],"region":{"top_left_x":146,"top_left_y":1980,"width":1775,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4f90a350ba640048a5eee0f92242f8b","type":"text","conversion_output":true,"text":"designed to simultaneously treat both components (bothersome SUI and bothersome UUI) will improve a","text_display":" designed to simultaneously treat both components (bothersome SUI and bothersome UUI) will improve a","confidence":1,"confidence_rate":1},{"cnt":[[146,2024],[995,2024],[995,2069],[146,2069]],"region":{"top_left_x":146,"top_left_y":2023,"width":849,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2041b46eb77543deabc8504a99afe309","type":"text","conversion_output":true,"text":"patient's outcome and perception of her condition.","text_display":" patient's outcome and perception of her condition.","confidence":1,"confidence_rate":1},{"cnt":[[142,2153],[1347,2153],[1347,2202],[142,2202]],"region":{"top_left_x":141,"top_left_y":2152,"width":1207,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06cb8a9f3cb64663820926ed34d45d6d","type":"section_header","conversion_output":false,"children_ids":["73fee46f06b141d2a7b06631cb264aba"],"text":"","text_display":""},{"cnt":[[146,2155],[1343,2155],[1343,2198],[146,2198]],"region":{"top_left_x":146,"top_left_y":2154,"width":1197,"height":44},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73fee46f06b141d2a7b06631cb264aba","type":"text","conversion_output":true,"parent_id":"06cb8a9f3cb64663820926ed34d45d6d","text":"2.5. Anti-incontinence surgical treatment outcomes in women with MUI","text_display":"\n\n\\subsection*{2.5. Anti-incontinence surgical treatment outcomes in women with MUI}","confidence":1,"confidence_rate":1},{"cnt":[[271,2209],[1966,2209],[1966,2254],[271,2254]],"region":{"top_left_x":270,"top_left_y":2208,"width":1696,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76d26e77e9aa45bbb59068603628e866","type":"text","conversion_output":true,"text":"Although \"traditional teaching\" is that women with MUI should not undergo anti-incontinence surgery","text_display":"\n\nAlthough \"traditional teaching\" is that women with MUI should not undergo anti-incontinence surgery","confidence":1,"confidence_rate":1},{"cnt":[[146,2252],[1957,2252],[1957,2297],[146,2297]],"region":{"top_left_x":146,"top_left_y":2251,"width":1812,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd9ee24ecd53405984b21b68bb038d50","type":"text","conversion_output":true,"text":"for SUI due to potential risk of worsening OAB, this is not supported by recent literature for MUS outcomes.","text_display":" for SUI due to potential risk of worsening OAB, this is not supported by recent literature for MUS outcomes.","confidence":0.99072265625,"confidence_rate":0.9999175198058059},{"cnt":[[146,2297],[1869,2297],[1869,2340],[146,2340]],"region":{"top_left_x":146,"top_left_y":2296,"width":1724,"height":44},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0092b167ebfd4dbaba21eea464ed57e4","type":"text","conversion_output":true,"text":"There continues to be accumulating evidence regarding the efficacy of midurethral sling (MUS) for the","text_display":" There continues to be accumulating evidence regarding the efficacy of midurethral sling (MUS) for the","confidence":1,"confidence_rate":1},{"cnt":[[146,2342],[1884,2342],[1884,2385],[146,2385]],"region":{"top_left_x":146,"top_left_y":2341,"width":1739,"height":44},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e31b64bede214cdd927ad9e8a658b4f7","type":"text","conversion_output":true,"text":"treatment of MUI (See Table 1). The MUS has proven to be highly effective for SUI treatment with cure","text_display":" treatment of MUI (See Table 1). The MUS has proven to be highly effective for SUI treatment with cure","confidence":1,"confidence_rate":1},{"cnt":[[146,2380],[1910,2380],[1910,2430],[146,2430]],"region":{"top_left_x":146,"top_left_y":2380,"width":1764,"height":50},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f023d24e14354765ab1d0ba71a1f0dbd","type":"text","conversion_output":true,"text":"rates up to \\(80 \\%\\) at 1 year \\({ }^{24}\\) and there is more recent evidence supporting improved OAB outcomes also.","text_display":" rates up to \\(80 \\%\\) at 1 year \\({ }^{24}\\) and there is more recent evidence supporting improved OAB outcomes also.","confidence":0.8940628382842988,"confidence_rate":0.999125544923173},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2faaa9623d364ff4a3ef8951c410b6cf","type":"page_info","conversion_output":false,"text":"10","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cbb536d144842f8a6a857ea8ae92c02","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-11","page":11,"lines":[{"cnt":[[146,129],[408,129],[408,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":263,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0d3c3965a86478a86efb3adeb353fe3","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87b7c3f3cdd54e76b250006da6436456","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"799b9d8c2c3f48d4add147599b37d900","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,254],[146,254]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":40},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cecee167b14c401084d95bd698a0f616","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[271,260],[1878,260],[1878,303],[271,303]],"region":{"top_left_x":270,"top_left_y":259,"width":1608,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"278c42ad18314975bceaf62358da7d51","type":"text","conversion_output":true,"text":"A systematic review by Jain et al in 2011 including six randomized trials and seven prospective","text_display":"\n\nA systematic review by Jain et al in 2011 including six randomized trials and seven prospective","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1901,305],[1901,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1756,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b2f28d8a2be4f48ba75067755375763","type":"text","conversion_output":true,"text":"studies reported that the overall cure rate of urgency and the UUI component of MUI after MUS was 30-","text_display":" studies reported that the overall cure rate of urgency and the UUI component of MUI after MUS was 30","confidence":0.7744140625,"confidence_rate":0.9975911269085119},{"cnt":[[146,346],[1953,346],[1953,391],[146,391]],"region":{"top_left_x":146,"top_left_y":345,"width":1807,"height":47},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88c6b6c0d30c483a9f370e7375d986a7","type":"text","conversion_output":true,"text":"\\(85 \\%\\) at a follow-up of a few months to 5 years. \\({ }^{25}\\) Whether authors consider MUS to be helpful or hurtful for","text_display":"\\(85 \\%\\) at a follow-up of a few months to 5 years. \\({ }^{25}\\) Whether authors consider MUS to be helpful or hurtful for","confidence":0.9926791191101074,"confidence_rate":0.9999407452229804},{"cnt":[[146,391],[1897,391],[1897,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1752,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca7c2fa700134819b149363d014e5299","type":"text","conversion_output":true,"text":"MUI often depends on the point of view of a paper, and may also be highly dependent on the definitions","text_display":" MUI often depends on the point of view of a paper, and may also be highly dependent on the definitions","confidence":1,"confidence_rate":1},{"cnt":[[146,434],[1936,434],[1936,479],[146,479]],"region":{"top_left_x":146,"top_left_y":433,"width":1790,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1d6a0bb1b7e45878c6c91d837f99b12","type":"text","conversion_output":true,"text":"used to define \"persistent OAB.\" Some studies report that more than \\(50 \\%\\) of women with MUI experience","text_display":" used to define \"persistent OAB.\" Some studies report that more than \\(50 \\%\\) of women with MUI experience","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[146,477],[1871,477],[1871,522],[146,522]],"region":{"top_left_x":146,"top_left_y":476,"width":1726,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9837727d863940449290df6385ede509","type":"text","conversion_output":true,"text":"complete resolution or improvement of OAB symptoms after MUS treatment. \\({ }^{26}\\) However, other studies","text_display":" complete resolution or improvement of OAB symptoms after MUS treatment. \\({ }^{26}\\) However, other studies","confidence":1,"confidence_rate":1},{"cnt":[[146,520],[1893,520],[1893,569],[146,569]],"region":{"top_left_x":146,"top_left_y":519,"width":1747,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1147cff7637c485c958fe609fb28123c","type":"text","conversion_output":true,"text":"report that MUI is a risk factor for failure of both SUI and OAB outcomes \\({ }^{27}\\) or that MUS may exacerbate","text_display":" report that MUI is a risk factor for failure of both SUI and OAB outcomes \\({ }^{27}\\) or that MUS may exacerbate","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[146,565],[1910,565],[1910,612],[146,612]],"region":{"top_left_x":146,"top_left_y":565,"width":1764,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"406c394ad2444e3cb2c21bcc05e3a80b","type":"text","conversion_output":true,"text":"OAB symptoms. One study reported a failure rate of \\(42 \\%\\) compared to \\(12 \\%\\) for SUI outcomes in women","text_display":" OAB symptoms. One study reported a failure rate of \\(42 \\%\\) compared to \\(12 \\%\\) for SUI outcomes in women","confidence":0.9980480668600649,"confidence_rate":0.9999817399737813},{"cnt":[[146,610],[1738,610],[1738,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1593,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f247ec9b78b9448497df9905d189fe52","type":"text","conversion_output":true,"text":"with baseline MUI compared to those with SUI alone. \\({ }^{28}\\) Whether there may be specific patient","text_display":" with baseline MUI compared to those with SUI alone. \\({ }^{28}\\) Whether there may be specific patient","confidence":1,"confidence_rate":1},{"cnt":[[146,653],[1949,653],[1949,698],[146,698]],"region":{"top_left_x":146,"top_left_y":653,"width":1803,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27264f4443bd4e99a2f145c4bbeb28bf","type":"text","conversion_output":true,"text":"characteristics that are associated with resolution or exacerbation of OAB symptoms also remains unclear.","text_display":" characteristics that are associated with resolution or exacerbation of OAB symptoms also remains unclear.","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[271,696],[1962,696],[1962,741],[271,741]],"region":{"top_left_x":270,"top_left_y":696,"width":1692,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"059e8b6ae47d41edb1414a327e5c8da2","type":"text","conversion_output":true,"text":"The Trial of Mid-Urethral Slings (TOMUS) by Richter et al for the UITN randomized 597 women with","text_display":"\n\nThe Trial of Mid-Urethral Slings (TOMUS) by Richter et al for the UITN randomized 597 women with","confidence":1,"confidence_rate":1},{"cnt":[[146,741],[1893,741],[1893,788],[146,788]],"region":{"top_left_x":146,"top_left_y":741,"width":1747,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3648834abdde43dd844ca394254aa99f","type":"text","conversion_output":true,"text":"pure SUI or SUI-predominant MUI (based on MESA scores) to retropubic versus transobturator MUS. \\({ }^{24}\\)","text_display":" pure SUI or SUI-predominant MUI (based on MESA scores) to retropubic versus transobturator MUS. \\({ }^{24}\\)","confidence":0.9975595474243164,"confidence_rate":0.9999775834133297},{"cnt":[[146,786],[1970,786],[1970,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1825,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5c7f891d7c54628aaf920fe0b40ef17","type":"text","conversion_output":true,"text":"Success was a composite outcome, defined as: 1) negative CST; 2) negative pad test; 3) no retreatment for","text_display":" Success was a composite outcome, defined as: 1) negative CST; 2) negative pad test; 3) no retreatment for","confidence":0.9580280780792236,"confidence_rate":0.9996102742139127},{"cnt":[[146,829],[1863,829],[1863,874],[146,874]],"region":{"top_left_x":146,"top_left_y":829,"width":1717,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5675f372dccf4ac7851cd554d7e91a0c","type":"text","conversion_output":true,"text":"SUI; 4) no self-reported leakage on 3-day voiding diary; 4) no self-reported SUI symptoms; 5) no self-","text_display":" SUI; 4) no self-reported leakage on 3-day voiding diary; 4) no self-reported SUI symptoms; 5) no self","confidence":0.9990234375,"confidence_rate":0.9999908688300274},{"cnt":[[146,872],[1953,872],[1953,917],[146,917]],"region":{"top_left_x":146,"top_left_y":872,"width":1807,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0cb2a1124144d33ab2a2494b362ed9c","type":"text","conversion_output":true,"text":"reported retreatment of SUI. At baseline, \\(70 / 589(12 \\%)\\) had detrusor overactivity on UDE, but overall mean","text_display":"reported retreatment of SUI. At baseline, \\(70 / 589(12 \\%)\\) had detrusor overactivity on UDE, but overall mean","confidence":0.97705078125,"confidence_rate":0.9997927299514795},{"cnt":[[146,917],[1886,917],[1886,965],[146,965]],"region":{"top_left_x":146,"top_left_y":917,"width":1741,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93df7655d6fa4691ab62c3d7e0e2bc28","type":"text","conversion_output":true,"text":"urge scores on MESA were low (5.9-6.6 \\(\\pm 4\\) points). One year postoperatively, \\(11 \\%\\) had persistent UUI","text_display":" urge scores on MESA were low (5.9-6.6 \\(\\pm 4\\) points). One year postoperatively, \\(11 \\%\\) had persistent UUI","confidence":0.8304769504733107,"confidence_rate":0.9982972760150866},{"cnt":[[146,962],[1876,962],[1876,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":962,"width":1730,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"035c277488ca435dbe40a40e8b802b10","type":"text","conversion_output":true,"text":"(defined as any MESA urge item response of \"sometimes\" or \"often\" or post-operative initiation of anti-","text_display":" (defined as any MESA urge item response of \"sometimes\" or \"often\" or post-operative initiation of anti","confidence":1,"confidence_rate":1},{"cnt":[[146,1005],[1912,1005],[1912,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1005,"width":1767,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8746451a735433b94d4c758818470d6","type":"text","conversion_output":true,"text":"muscarinic treatment for UUI). The rate of de novo UUI was \\(1 / 597(0.002 \\%)\\). The UDI-irritative subscale","text_display":"muscarinic treatment for UUI). The rate of de novo UUI was \\(1 / 597(0.002 \\%)\\). The UDI-irritative subscale","confidence":0.9079053672714963,"confidence_rate":0.9991220662742605},{"cnt":[[146,1051],[1893,1051],[1893,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1050,"width":1747,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35fbb4809a0b4e57837762c963d8a3c4","type":"text","conversion_output":true,"text":"scores improved from a mean of \\(41.2(25.4)\\), to \\(9.2(15.2)\\), and \\(8.9(15.1)\\) at baseline, 6 and 12 months,","text_display":" scores improved from a mean of \\(41.2(25.4)\\), to \\(9.2(15.2)\\), and \\(8.9(15.1)\\) at baseline, 6 and 12 months,","confidence":0.8510861692484468,"confidence_rate":0.9986792180907665},{"cnt":[[146,1096],[1869,1096],[1869,1139],[146,1139]],"region":{"top_left_x":146,"top_left_y":1095,"width":1724,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b18c5eb3be3945778c2d27eb57a2a5bf","type":"text","conversion_output":true,"text":"respectively suggesting improvement in OAB symptoms (unpublished data, personal communication).","text_display":" respectively suggesting improvement in OAB symptoms (unpublished data, personal communication).","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[146,1137],[1949,1137],[1949,1184],[146,1184]],"region":{"top_left_x":146,"top_left_y":1136,"width":1803,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72cd134c1deb44f3afb01b5968fdd57c","type":"text","conversion_output":true,"text":"Higher baseline MESA urge scores increased the risk of overall (objective and subjective) sling failure. \\({ }^{29}\\) In","text_display":" Higher baseline MESA urge scores increased the risk of overall (objective and subjective) sling failure. \\({ }^{29}\\) In","confidence":0.9970724582672119,"confidence_rate":0.999976545592139},{"cnt":[[146,1182],[1919,1182],[1919,1227],[146,1227]],"region":{"top_left_x":146,"top_left_y":1181,"width":1773,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4e2a3291e064b208810745f8528c8e8","type":"text","conversion_output":true,"text":"a planned secondary analysis evaluating UDE predictors, detrusor overactivity on preoperative UDE was","text_display":" a planned secondary analysis evaluating UDE predictors, detrusor overactivity on preoperative UDE was","confidence":1,"confidence_rate":1},{"cnt":[[146,1225],[1008,1225],[1008,1270],[146,1270]],"region":{"top_left_x":146,"top_left_y":1224,"width":862,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b12305eda6584d56a9875564c356a8ab","type":"text","conversion_output":true,"text":"not a risk factor for objective or subjective failure. \\({ }^{30}\\)","text_display":" not a risk factor for objective or subjective failure. \\({ }^{30}\\)","confidence":1,"confidence_rate":1},{"cnt":[[271,1268],[1871,1268],[1871,1313],[271,1313]],"region":{"top_left_x":270,"top_left_y":1267,"width":1602,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50c545e8c0db420aa44af5cf010c1d32","type":"text","conversion_output":true,"text":"Barber et al performed a second trial also comparing retropubic versus transobturator MUS for","text_display":"\n\nBarber et al performed a second trial also comparing retropubic versus transobturator MUS for","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[146,1311],[1944,1311],[1944,1360],[146,1360]],"region":{"top_left_x":146,"top_left_y":1310,"width":1799,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68e148b2002a46959ac7daec4b292976","type":"text","conversion_output":true,"text":"SUI. \\({ }^{27,31}\\) Although women with baseline detrusor overactivity were excluded, \\(71 \\%\\) had baseline UUI based","text_display":" SUI. \\({ }^{27,31}\\) Although women with baseline detrusor overactivity were excluded, \\(71 \\%\\) had baseline UUI based","confidence":0.9322266262024641,"confidence_rate":0.9994201736792141},{"cnt":[[146,1354],[1796,1354],[1796,1403],[146,1403]],"region":{"top_left_x":146,"top_left_y":1353,"width":1651,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e27aad1b96524bd2ad69395981398b98","type":"text","conversion_output":true,"text":"on the UUI item on the PFDI-20 questionnaire \\({ }^{32}\\). At 1 year postoperative \\(31 \\%\\) of women reported","text_display":" on the UUI item on the PFDI-20 questionnaire \\({ }^{32}\\). At 1 year postoperative \\(31 \\%\\) of women reported","confidence":1,"confidence_rate":1},{"cnt":[[146,1401],[1811,1401],[1811,1446],[146,1446]],"region":{"top_left_x":146,"top_left_y":1400,"width":1666,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eeb3bba228ce44af9c0f1c5aec09f9e1","type":"text","conversion_output":true,"text":"bothersome UUI and \\(4-10 \\%\\) had new or worsened UUI. \\(45 \\%\\) of women were failures, defined as a","text_display":" bothersome UUI and \\(4-10 \\%\\) had new or worsened UUI. \\(45 \\%\\) of women were failures, defined as a","confidence":0.9699554443359375,"confidence_rate":0.9996980144957748},{"cnt":[[146,1444],[1910,1444],[1910,1491],[146,1491]],"region":{"top_left_x":146,"top_left_y":1443,"width":1764,"height":49},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04bcc1176a6347fd8268be8f9da5ecc7","type":"text","conversion_output":true,"text":"composite outcome of \"abnormal bladder function\" defined as: 1) incontinence symptoms of any type; 2)","text_display":" composite outcome of \"abnormal bladder function\" defined as: 1) incontinence symptoms of any type; 2)","confidence":0.9503127620776013,"confidence_rate":0.9995193219275493},{"cnt":[[146,1489],[1888,1489],[1888,1534],[146,1534]],"region":{"top_left_x":146,"top_left_y":1488,"width":1743,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb79d3d1a8424b6798d558f8113137a3","type":"text","conversion_output":true,"text":"positive CST; 3) retreatment for SUI; 4) postoperative urinary retention. Overall, \\(79 \\%\\) reported Patient-","text_display":" positive CST; 3) retreatment for SUI; 4) postoperative urinary retention. Overall, \\(79 \\%\\) reported Patient","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[146,1532],[1927,1532],[1927,1579],[146,1579]],"region":{"top_left_x":146,"top_left_y":1531,"width":1782,"height":49},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a3162b244084f9980f4746b7a56f4c8","type":"text","conversion_output":true,"text":"Global Impression of Improvement \\({ }^{3}\\) (PGI-I) scores as \"much better/very much better\". The 2 UDI-irritative","text_display":"Global Impression of Improvement \\({ }^{3}\\) (PGI-I) scores as \"much better/very much better\". The 2 UDI-irritative","confidence":0.99951171875,"confidence_rate":0.9999960292721264},{"cnt":[[146,1577],[1901,1577],[1901,1622],[146,1622]],"region":{"top_left_x":146,"top_left_y":1576,"width":1756,"height":47},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d90857f4be0e46b0ad61ed459d90c278","type":"text","conversion_output":true,"text":"items in the UDI-6 (UUI and frequency) improved from a median of 3 points at baseline to 0 points at 12","text_display":" items in the UDI-6 (UUI and frequency) improved from a median of 3 points at baseline to 0 points at 12","confidence":0.9970703125,"confidence_rate":0.9999740358465011},{"cnt":[[146,1620],[1962,1620],[1962,1665],[146,1665]],"region":{"top_left_x":146,"top_left_y":1619,"width":1816,"height":47},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf2d8a0c42ce48348e058e102579ad9b","type":"text","conversion_output":true,"text":"months, also suggesting improvement in OAB symptoms (unpublished data, personal communication). In a","text_display":" months, also suggesting improvement in OAB symptoms (unpublished data, personal communication). In a","confidence":0.9990234375,"confidence_rate":0.9999906949037896},{"cnt":[[146,1663],[1796,1663],[1796,1708],[146,1708]],"region":{"top_left_x":146,"top_left_y":1662,"width":1651,"height":47},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"003cae21c3294830947c320edf84bc4e","type":"text","conversion_output":true,"text":"secondary analysis, baseline UUI was not a risk factor for recurrent UI 1 year postoperatively, but","text_display":" secondary analysis, baseline UUI was not a risk factor for recurrent UI 1 year postoperatively, but","confidence":1,"confidence_rate":1},{"cnt":[[146,1710],[1815,1710],[1815,1755],[146,1755]],"region":{"top_left_x":146,"top_left_y":1710,"width":1670,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e61c0cb8f4944fb9623b1ace483ab4f","type":"text","conversion_output":true,"text":"preoperative use of anti-muscarinic medications was. However, \\(53 \\%(10 / 19)\\) of women taking anti-","text_display":" preoperative use of anti-muscarinic medications was. However, \\(53 \\%(10 / 19)\\) of women taking anti","confidence":0.9313144683837891,"confidence_rate":0.9993026130531797},{"cnt":[[146,1753],[1416,1753],[1416,1798],[146,1798]],"region":{"top_left_x":146,"top_left_y":1753,"width":1270,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64137d612872482aa3c6321030524acf","type":"text","conversion_output":true,"text":"muscarinics at baseline were no longer taking them 1 year postoperatively.","text_display":"muscarinics at baseline were no longer taking them 1 year postoperatively.","confidence":1,"confidence_rate":1},{"cnt":[[271,1796],[1837,1796],[1837,1841],[271,1841]],"region":{"top_left_x":270,"top_left_y":1796,"width":1567,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2db59bd6089a4dac8478325ee5abb9eb","type":"text","conversion_output":true,"text":"A secondary analysis by Palva et al of another randomized trial comparing retropubic versus","text_display":"\n\nA secondary analysis by Palva et al of another randomized trial comparing retropubic versus","confidence":1,"confidence_rate":1},{"cnt":[[146,1839],[1884,1839],[1884,1884],[146,1884]],"region":{"top_left_x":146,"top_left_y":1839,"width":1739,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"478ee651a2a14a65a014cbf4172e85a9","type":"text","conversion_output":true,"text":"transobturator MUS evaluated the prevalence of urinary urgency symptoms after MUS. \\({ }^{33}\\) In the original","text_display":" transobturator MUS evaluated the prevalence of urinary urgency symptoms after MUS. \\({ }^{33}\\) In the original","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[146,1882],[1910,1882],[1910,1929],[146,1929]],"region":{"top_left_x":146,"top_left_y":1882,"width":1764,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc9140f2747c496c959b89fa179cd3f6","type":"text","conversion_output":true,"text":"inclusion criteria, only women with a \"detrusor instability score\" \\(\\leq 7\\) (suggesting pure SUI) were included.","text_display":" inclusion criteria, only women with a \"detrusor instability score\" \\(\\leq 7\\) (suggesting pure SUI) were included.","confidence":1,"confidence_rate":1},{"cnt":[[146,1927],[1966,1927],[1966,1972],[146,1972]],"region":{"top_left_x":146,"top_left_y":1927,"width":1820,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5712ba5147fd42059b9b1ffa2e4188b1","type":"text","conversion_output":true,"text":"However, the authors found that despite this inclusion criteria, a considerable proportion of women reported","text_display":" However, the authors found that despite this inclusion criteria, a considerable proportion of women reported","confidence":1,"confidence_rate":1},{"cnt":[[146,1972],[1955,1972],[1955,2017],[146,2017]],"region":{"top_left_x":146,"top_left_y":1972,"width":1810,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74da30065fd44714bbee2374000aeb8c","type":"text","conversion_output":true,"text":"at least slightly bothersome urinary frequency and UUI on the UDI-6 ( \\(\\sim 75 \\%\\) reported urinary frequency and","text_display":" at least slightly bothersome urinary frequency and UUI on the UDI-6 ( \\(\\sim 75 \\%\\) reported urinary frequency and","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[146,2015],[1964,2015],[1964,2060],[146,2060]],"region":{"top_left_x":146,"top_left_y":2015,"width":1818,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5f55589666f42cc84b6b3376aabadb0","type":"text","conversion_output":true,"text":"\\(66 \\%\\) had UUI at baseline that was at least \"somewhat bothersome\"). At 36 months postoperatively, \\(51-60 \\%\\)","text_display":" \\(66 \\%\\) had UUI at baseline that was at least \"somewhat bothersome\"). At 36 months postoperatively, \\(51-60 \\%\\)","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[146,2058],[1974,2058],[1974,2105],[146,2105]],"region":{"top_left_x":146,"top_left_y":2058,"width":1829,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a690e61d8dc4495b69252a615a85044","type":"text","conversion_output":true,"text":"were \"cured\" of urinary frequency and \\(73-75 \\%\\) were cured of UUI based on UDI-6 responses. The rate of de","text_display":" were \"cured\" of urinary frequency and \\(73-75 \\%\\) were cured of UUI based on UDI-6 responses. The rate of de","confidence":0.99169921875,"confidence_rate":0.9999249089043513},{"cnt":[[146,2103],[1968,2103],[1968,2151],[146,2151]],"region":{"top_left_x":146,"top_left_y":2103,"width":1822,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c78a25e186b4d97ac22804a175aaf73","type":"text","conversion_output":true,"text":"novo urgency was \\(3.1-4.5 \\%\\) at 12 months and \\(5.6-6.2 \\%\\) at 36 months. The authors go so far as to conclude","text_display":" novo urgency was \\(3.1-4.5 \\%\\) at 12 months and \\(5.6-6.2 \\%\\) at 36 months. The authors go so far as to conclude","confidence":0.99951171875,"confidence_rate":0.9999958958025558},{"cnt":[[146,2148],[1257,2148],[1257,2189],[146,2189]],"region":{"top_left_x":146,"top_left_y":2148,"width":1111,"height":42},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"974a9d47f5334b33bfb6c37fae8340de","type":"text","conversion_output":true,"text":"that MUS \"can be recommended in cases of mixed incontinence\".","text_display":" that MUS \"can be recommended in cases of mixed incontinence\".","confidence":1,"confidence_rate":1},{"cnt":[[271,2191],[1949,2191],[1949,2237],[271,2237]],"region":{"top_left_x":270,"top_left_y":2191,"width":1679,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6e03ec881a241328159ce79213d113d","type":"text","conversion_output":true,"text":"Abdel-fattah performed an RCT comparing two transobturator MUS including 341 women with pure","text_display":"\n\nAbdel-fattah performed an RCT comparing two transobturator MUS including 341 women with pure","confidence":1,"confidence_rate":1},{"cnt":[[146,2237],[1979,2237],[1979,2279],[146,2279]],"region":{"top_left_x":146,"top_left_y":2236,"width":1833,"height":44},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67f527dd9f184caf93144d47a0a6de2d","type":"text","conversion_output":true,"text":"SUI or SUI-predominant MUI. In a secondary analysis evaluating only the subset of women with urodynamic","text_display":" SUI or SUI-predominant MUI. In a secondary analysis evaluating only the subset of women with urodynamic","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[146,2277],[1931,2277],[1931,2322],[146,2322]],"region":{"top_left_x":146,"top_left_y":2277,"width":1786,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3037fe217dd341c1872abfa0143d229a","type":"text","conversion_output":true,"text":"MUI, ( \\(n =83 / 341,24 \\%\\) ), \\(52 \\%\\) of women were cured of urgency, \\(23 \\%\\) had persistent urgency, and \\(25 \\%\\) had","text_display":" MUI, ( \\(n =83 / 341,24 \\%\\) ), \\(52 \\%\\) of women were cured of urgency, \\(23 \\%\\) had persistent urgency, and \\(25 \\%\\) had","confidence":0.9279081423164826,"confidence_rate":0.9993661117068043},{"cnt":[[146,2320],[1927,2320],[1927,2368],[146,2368]],"region":{"top_left_x":146,"top_left_y":2320,"width":1782,"height":48},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4321602b5a4b42debc7d14130ed56d15","type":"text","conversion_output":true,"text":"worsened urgency. \\({ }^{34} 58 \\%\\) were cured of UUI, \\(24 \\%\\) had persistent UUI, and \\(19 \\%\\) had worsened UUI at 12","text_display":" worsened urgency. \\({ }^{34} 58 \\%\\) were cured of UUI, \\(24 \\%\\) had persistent UUI, and \\(19 \\%\\) had worsened UUI at 12","confidence":1,"confidence_rate":1},{"cnt":[[146,2368],[1927,2368],[1927,2413],[146,2413]],"region":{"top_left_x":146,"top_left_y":2367,"width":1782,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea0b4736544b4883aeec627aad028161","type":"text","conversion_output":true,"text":"months postoperative. 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At 12 months, \\(75 \\%\\) of women with MUI experienced overall \"cure\" of incontinence","confidence":0.9990234375,"confidence_rate":0.9999911978797494},{"cnt":[[146,2411],[1974,2411],[1974,2456],[146,2456]],"region":{"top_left_x":146,"top_left_y":2410,"width":1829,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7a322836d0d4ed18f2c5b6b46870562","type":"text","conversion_output":true,"text":"based on the PGI-I \\(\\leq 2\\), although in their original report of their primary trial findings, preoperative UUI was a","text_display":" based on the PGI-I \\(\\leq 2\\), although in their original report of their primary trial findings, preoperative UUI was a","confidence":1,"confidence_rate":1},{"cnt":[[146,2454],[767,2454],[767,2499],[146,2499]],"region":{"top_left_x":146,"top_left_y":2453,"width":621,"height":46},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa8c02c5b3c84cdfbc646d40ba8bb473","type":"text","conversion_output":true,"text":"risk factor for sling failure by PGI-I. \\({ }^{35}\\)","text_display":" risk factor for sling failure by PGI-I. \\({ }^{35}\\)","confidence":0.99951171875,"confidence_rate":0.9999907849387211},{"cnt":[[1038,2548],[1083,2548],[1083,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":46,"height":46},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1928a6531b6405591503b6465698fa7","type":"page_info","conversion_output":false,"text":"11","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5463c326de0d4e2a8f5a9f085915a3f7","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-12","page":12,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc7491b66af44e81bd83591b1bce6122","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4b01475f99d412584a64e48e8e93a24","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"582e19c102d44876a440dcf7981a8ba1","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[357,215],[357,256],[146,256]],"region":{"top_left_x":146,"top_left_y":214,"width":211,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8191c45d60d46efbf754dcf041a556b","type":"section_header","conversion_output":false,"children_ids":["b92cd58f3f204569b9f0f283a6b97425"],"text":"","text_display":""},{"cnt":[[148,217],[354,217],[354,251],[148,251]],"region":{"top_left_x":148,"top_left_y":216,"width":207,"height":36},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b92cd58f3f204569b9f0f283a6b97425","type":"text","conversion_output":true,"parent_id":"a8191c45d60d46efbf754dcf041a556b","text":"Confidential","text_display":"\n\n\\section*{Confidential}","confidence":1,"confidence_rate":1},{"cnt":[[271,262],[1858,262],[1858,303],[271,303]],"region":{"top_left_x":270,"top_left_y":262,"width":1589,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5af0a56bfa3140538dc11dc4d01fef65","type":"text","conversion_output":true,"text":"In summary, recent secondary analyses of trials have suggested that over half of women may","text_display":"\n\nIn summary, recent secondary analyses of trials have suggested that over half of women may","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1966,305],[1966,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1820,"height":41},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6e7a403842447c186a34315eb763303","type":"text","conversion_output":true,"text":"experience improvement and/or \"cure\" of OAB symptoms after MUS; 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Randomized trials reporting midurethral sling outcomes in women with MUI* †}\n\\begin{tabular}{|l|l|l|l|l|l|l|l|l|}\n\\hline First Author & No. Pts & Inclusion criteria & Primary objective & \\% MUI at baseline & Followup & \\% postop OAB and definition & De novo OAB & Other relevant findings \\\\\n\\hline Richter, \\({ }^{24,}\\) 29, 30 & 597 & Pure SUI / SUIpredom by MESA & TVT vs TVT-O or Monarc & -12\\% DO & 1 year & 10-12\\% persistent UUI (by MESA or treatment) & 0.002\\% New UUI & -MESA urge score risk factor for failure -Baseline DO not risk factor \\\\\n\\hline Barber \\({ }^{27}\\), 31 & 170 & Urodynamic SUI and no DO & TVT vs Monarc & \\begin{tabular}{l}\n-71\\% UUI (PFDI) \\\\\n-14\\% preop anticholin\n\\end{tabular} & 1 year & \\begin{tabular}{l}\n-31\\% UUI postop (PFDI) \\\\\n-4-10\\% new/worse UUI (PFDI) -16\\% anticholin postop\n\\end{tabular} & 4-10\\% New / worse UUI & -79\\% \"Cure\" by PGI-I <2 \\\\\n\\hline Palva \\({ }^{33}\\) & 267 & Pure SUI / SUIpredom by 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Limitations of existing MUS trials for the MUI population","text_display":"\n\n\\subsection*{2.6. Limitations of existing MUS trials for the MUI population}","confidence":1,"confidence_rate":1},{"cnt":[[271,2252],[1880,2252],[1880,2295],[271,2295]],"region":{"top_left_x":270,"top_left_y":2251,"width":1610,"height":44},"line":199,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccca71876aa241e19f55cd6a88fd0f58","type":"text","conversion_output":true,"text":"The existing MUS RCT data are limited because they do not focus on women with MUI and the","text_display":"\n\nThe existing MUS RCT data are limited because they do not focus on women with MUI and the","confidence":1,"confidence_rate":1},{"cnt":[[146,2295],[1944,2295],[1944,2340],[146,2340]],"region":{"top_left_x":146,"top_left_y":2294,"width":1799,"height":46},"line":200,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c05fcca1e8c742ec807fed4485107375","type":"text","conversion_output":true,"text":"inclusion criteria almost always require one condition to be \"predominant\" or \"more bothersome\" (e.g. SUI-","text_display":" inclusion criteria almost always require one condition to be \"predominant\" or \"more bothersome\" (e.g. SUI","confidence":1,"confidence_rate":1},{"cnt":[[146,2340],[1901,2340],[1901,2383],[146,2383]],"region":{"top_left_x":146,"top_left_y":2339,"width":1756,"height":44},"line":201,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ef393abaae0460498db0dee9cf52f16","type":"text","conversion_output":true,"text":"predominant for most surgical trials and UUI-predominant for most medication trials). 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Finally,","text_display":"\n\nSUI and OAB outcomes separately, which is highly important when counseling a patient with MUI. Finally,","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1897,305],[1897,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1752,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b56f140f36a439f9463c1e6e033eda5","type":"text","conversion_output":true,"text":"ancillary studies from existing trials are underpowered to determine SUI and OAB outcomes separately.","text_display":" ancillary studies from existing trials are underpowered to determine SUI and OAB outcomes separately.","confidence":1,"confidence_rate":1},{"cnt":[[146,387],[1390,387],[1390,436],[146,436]],"region":{"top_left_x":146,"top_left_y":386,"width":1245,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31e6897914134b648d8ddbd2c43e117c","type":"section_header","conversion_output":false,"children_ids":["27d46e12d18d4ae2a6d18735891c3057"],"text":"","text_display":""},{"cnt":[[146,391],[1386,391],[1386,432],[146,432]],"region":{"top_left_x":146,"top_left_y":391,"width":1240,"height":41},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27d46e12d18d4ae2a6d18735891c3057","type":"text","conversion_output":true,"parent_id":"31e6897914134b648d8ddbd2c43e117c","text":"2.7. 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After 4-5 months of enrollment as a feasibility study,","text_display":" including TVT, TOT, TVT-O, fascial sling and Burch). After 4-5 months of enrollment as a feasibility study,","confidence":1,"confidence_rate":1},{"cnt":[[146,621],[1785,621],[1785,664],[146,664]],"region":{"top_left_x":146,"top_left_y":620,"width":1640,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3bc6ab4379d46b19d26f935e7ad7dee","type":"text","conversion_output":true,"text":"27 women were randomized out of 1190 women screened and the study was stopped due to low","text_display":" 27 women were randomized out of 1190 women screened and the study was stopped due to low","confidence":1,"confidence_rate":1},{"cnt":[[146,662],[1962,662],[1962,707],[146,707]],"region":{"top_left_x":146,"top_left_y":661,"width":1816,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b51fdb21c7b40e8914756c4e987c731","type":"text","conversion_output":true,"text":"enrollment. The investigators felt recruitment was challenging at least in part due to the divergent treatment","text_display":" enrollment. The investigators felt recruitment was challenging at least in part due to the divergent treatment","confidence":1,"confidence_rate":1},{"cnt":[[146,709],[1575,709],[1575,750],[146,750]],"region":{"top_left_x":146,"top_left_y":708,"width":1429,"height":42},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28e0ed453b15474dbcd0b136b5823b65","type":"text","conversion_output":true,"text":"approaches, but also because of the practical trial design and strict inclusion criteria.","text_display":" approaches, but also because of the practical trial design and strict inclusion criteria.","confidence":0.998046875,"confidence_rate":0.9999792019733479},{"cnt":[[273,752],[1936,752],[1936,793],[273,793]],"region":{"top_left_x":272,"top_left_y":751,"width":1664,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbc16940eaa5468db3642bdf36e94268","type":"text","conversion_output":true,"text":"Based on unpublished data from MIMOSA: of 24 women randomized with complete follow-up data","text_display":"\n\nBased on unpublished data from MIMOSA: of 24 women randomized with complete follow-up data","confidence":1,"confidence_rate":1},{"cnt":[[146,795],[1962,795],[1962,840],[146,840]],"region":{"top_left_x":146,"top_left_y":794,"width":1816,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7856037274044def9c6d2156e9c0f1f0","type":"text","conversion_output":true,"text":"at 6 months, \\(71 \\%\\) met criteria of optimal outcome (defined as score \\(\\leq 2\\) on PGI-I and a score of \\(\\leq 2\\) on PGI-","text_display":" at 6 months, \\(71 \\%\\) met criteria of optimal outcome (defined as score \\(\\leq 2\\) on PGI-I and a score of \\(\\leq 2\\) on PGI","confidence":0.9960973262786865,"confidence_rate":0.9999676839186694},{"cnt":[[146,838],[1708,838],[1708,883],[146,883]],"region":{"top_left_x":146,"top_left_y":837,"width":1563,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"918657cf94104d32927bad02262d105a","type":"text","conversion_output":true,"text":"S), suggesting that surgical treatment may improve MUI symptoms at least in the short term.","text_display":"S), suggesting that surgical treatment may improve MUI symptoms at least in the short term.","confidence":0.9228515625,"confidence_rate":0.9991640279725426},{"cnt":[[271,883],[1910,883],[1910,926],[271,926]],"region":{"top_left_x":270,"top_left_y":883,"width":1640,"height":43},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd270fbbc55c4c448375ee4199db6d04","type":"text","conversion_output":true,"text":"To avoid the challenges encountered in MIMOSA, the ESTEEM protocol team carefully designed","text_display":"\n\nTo avoid the challenges encountered in MIMOSA, the ESTEEM protocol team carefully designed","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[146,928],[1962,928],[1962,969],[146,969]],"region":{"top_left_x":146,"top_left_y":928,"width":1816,"height":41},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97eccff38525422ab2437eaa777ddec0","type":"text","conversion_output":true,"text":"our treatment to ensure a fair perception of treatment arms in an efficacy trial design, and carefully selected","text_display":" our treatment to ensure a fair perception of treatment arms in an efficacy trial design, and carefully selected","confidence":1,"confidence_rate":1},{"cnt":[[146,971],[1938,971],[1938,1016],[146,1016]],"region":{"top_left_x":146,"top_left_y":971,"width":1792,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22f0fe5e9ea642bd8163d4edbaa4ed60","type":"text","conversion_output":true,"text":"inclusion criteria that would not be overly strict, yet still allow recruitment of a MUI population (See Section","text_display":" inclusion criteria that would not be overly strict, yet still allow recruitment of a MUI population (See Section","confidence":1,"confidence_rate":1},{"cnt":[[146,1014],[531,1014],[531,1059],[146,1059]],"region":{"top_left_x":146,"top_left_y":1014,"width":385,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7f104fa252446fd97ae93d267f986c3","type":"text","conversion_output":true,"text":"4.2, Inclusion Criteria).","text_display":" 4.2, Inclusion Criteria).","confidence":0.99755859375,"confidence_rate":0.9999185236079889},{"cnt":[[144,1096],[1412,1096],[1412,1145],[144,1145]],"region":{"top_left_x":143,"top_left_y":1095,"width":1269,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1b37bafbc814f839b18cd71daa464ab","type":"section_header","conversion_output":false,"children_ids":["528806b3d1684519bb8d3f4220617bde"],"text":"","text_display":""},{"cnt":[[146,1100],[1407,1100],[1407,1141],[146,1141]],"region":{"top_left_x":146,"top_left_y":1100,"width":1262,"height":41},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"528806b3d1684519bb8d3f4220617bde","type":"text","conversion_output":true,"parent_id":"a1b37bafbc814f839b18cd71daa464ab","text":"2.8. Summary of known and potential risks and benefits of study treatment","text_display":"\n\n\\subsection*{2.8. Summary of known and potential risks and benefits of study treatment}","confidence":1,"confidence_rate":1},{"cnt":[[275,1156],[1893,1156],[1893,1192],[275,1192]],"region":{"top_left_x":275,"top_left_y":1155,"width":1618,"height":38},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5255796e811469c9bedcc0062bd7455","type":"text","conversion_output":true,"text":"BPTx has been shown to be beneficial when used for the treatment of MUI. Other than time and","text_display":"\n\nBPTx has been shown to be beneficial when used for the treatment of MUI. Other than time and","confidence":1,"confidence_rate":1},{"cnt":[[146,1199],[1931,1199],[1931,1242],[146,1242]],"region":{"top_left_x":146,"top_left_y":1198,"width":1786,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d398f2885d6640558bf328bcaf8162c4","type":"text","conversion_output":true,"text":"effort commitment and potential discomfort from a pelvic exam, the risks of BPTx are extremely low. MUS","text_display":" effort commitment and potential discomfort from a pelvic exam, the risks of BPTx are extremely low. MUS","confidence":1,"confidence_rate":1},{"cnt":[[148,1242],[1972,1242],[1972,1285],[148,1285]],"region":{"top_left_x":148,"top_left_y":1241,"width":1825,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2827141a65d4b7eb73dc8a0108c699d","type":"text","conversion_output":true,"text":"has been shown to be an effective treatment for SUI, and recent evidence suggests possible benefit for MUI","text_display":" has been shown to be an effective treatment for SUI, and recent evidence suggests possible benefit for MUI","confidence":1,"confidence_rate":1},{"cnt":[[148,1287],[1944,1287],[1944,1330],[148,1330]],"region":{"top_left_x":148,"top_left_y":1286,"width":1797,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28c01d49b500432c9082ab3d41a7b32b","type":"text","conversion_output":true,"text":"populations also. However, there are women with MUI who report persistent or worse UUI/OAB symptoms","text_display":" populations also. However, there are women with MUI who report persistent or worse UUI/OAB symptoms","confidence":1,"confidence_rate":1},{"cnt":[[148,1330],[1957,1330],[1957,1373],[148,1373]],"region":{"top_left_x":148,"top_left_y":1329,"width":1810,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35f3ff0771354e8f966545e35a623ea3","type":"text","conversion_output":true,"text":"after MUS and this is one potential risk. The remaining risks of MUS are not expected to be different for the","text_display":" after MUS and this is one potential risk. The remaining risks of MUS are not expected to be different for the","confidence":1,"confidence_rate":1},{"cnt":[[150,1375],[1914,1375],[1914,1420],[150,1420]],"region":{"top_left_x":150,"top_left_y":1375,"width":1765,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61998230a5254c91b0761bbe109df357","type":"text","conversion_output":true,"text":"ESTEEM population compared to previous studies including pure-SUI or SUI-predominant MUI subjects.","text_display":" ESTEEM population compared to previous studies including pure-SUI or SUI-predominant MUI subjects.","confidence":1,"confidence_rate":1},{"cnt":[[144,1457],[1665,1457],[1665,1506],[144,1506]],"region":{"top_left_x":143,"top_left_y":1456,"width":1523,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05e3eb3490a34802a56b9ec9878bc07a","type":"section_header","conversion_output":false,"children_ids":["c26165de6389453bab40af345f26f0b2"],"text":"","text_display":""},{"cnt":[[146,1461],[1661,1461],[1661,1502],[146,1502]],"region":{"top_left_x":146,"top_left_y":1460,"width":1515,"height":42},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c26165de6389453bab40af345f26f0b2","type":"text","conversion_output":true,"parent_id":"05e3eb3490a34802a56b9ec9878bc07a","text":"2.9. Significance of proposed study / Rationale for combined surgical and BPTx approach","text_display":"\n\n\\subsection*{2.9. Significance of proposed study / Rationale for combined surgical and BPTx approach}","confidence":1,"confidence_rate":1},{"cnt":[[275,1515],[1944,1515],[1944,1558],[275,1558]],"region":{"top_left_x":275,"top_left_y":1514,"width":1670,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b811f5de89c14e418e428c6378503265","type":"text","conversion_output":true,"text":"In summary, at least three gaps of knowledge contribute to the clinical challenge of treating women","text_display":"\n\nIn summary, at least three gaps of knowledge contribute to the clinical challenge of treating women","confidence":1,"confidence_rate":1},{"cnt":[[146,1560],[1931,1560],[1931,1601],[146,1601]],"region":{"top_left_x":146,"top_left_y":1559,"width":1786,"height":42},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7014a5d9de6413a9f3eabfcce61f566","type":"text","conversion_output":true,"text":"with MUI who desire SUI surgery. First, there is a lack of data to guide counseling on expected outcomes,","text_display":" with MUI who desire SUI surgery. First, there is a lack of data to guide counseling on expected outcomes,","confidence":1,"confidence_rate":1},{"cnt":[[148,1603],[1884,1603],[1884,1644],[148,1644]],"region":{"top_left_x":148,"top_left_y":1602,"width":1737,"height":42},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e330d1f32403403f86e4a8e877bdc15e","type":"text","conversion_output":true,"text":"particularly for the OAB component after MUS (what happens to OAB symptoms after MUS?). Second,","text_display":" particularly for the OAB component after MUS (what happens to OAB symptoms after MUS?). Second,","confidence":0.51513671875,"confidence_rate":0.9933887219008332},{"cnt":[[146,1646],[1936,1646],[1936,1691],[146,1691]],"region":{"top_left_x":146,"top_left_y":1645,"width":1790,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad033e09799342e8a2b1d7f489cbdc1e","type":"text","conversion_output":true,"text":"while persistent / worsened OAB symptoms after surgery are associated with patient dissatisfaction, there","text_display":" while persistent / worsened OAB symptoms after surgery are associated with patient dissatisfaction, there","confidence":0.9157476425170898,"confidence_rate":0.9992001886406587},{"cnt":[[148,1689],[1888,1689],[1888,1734],[148,1734]],"region":{"top_left_x":148,"top_left_y":1688,"width":1741,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df7b6d48b20044f491bdb0d36d75ea4b","type":"text","conversion_output":true,"text":"have been essentially no trials evaluating how to best treat this component peri-operatively (how do we","text_display":" have been essentially no trials evaluating how to best treat this component peri-operatively (how do we","confidence":0.9990236759185791,"confidence_rate":0.9999909555872323},{"cnt":[[148,1734],[1936,1734],[1936,1777],[148,1777]],"region":{"top_left_x":148,"top_left_y":1733,"width":1788,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e75197c7ea2b47f9b31fbf9ae7a90e96","type":"text","conversion_output":true,"text":"improve OAB outcomes after MUS? Can combined treatment improve outcomes for MUI?). Third, there is","text_display":" improve OAB outcomes after MUS? Can combined treatment improve outcomes for MUI?). Third, there is","confidence":0.9970703125,"confidence_rate":0.9999715150908018},{"cnt":[[146,1779],[1970,1779],[1970,1820],[146,1820]],"region":{"top_left_x":146,"top_left_y":1778,"width":1825,"height":42},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0e35d2bcd1d4113a408dd90f2930b12","type":"text","conversion_output":true,"text":"little data on what factors may increase the risk of MUS \"failure\" in this population (who should or should not","text_display":" little data on what factors may increase the risk of MUS \"failure\" in this population (who should or should not","confidence":1,"confidence_rate":1},{"cnt":[[146,1822],[1837,1822],[1837,1867],[146,1867]],"region":{"top_left_x":146,"top_left_y":1821,"width":1691,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f9032279de1402090520e1a418b5c1e","type":"text","conversion_output":true,"text":"get a MUS if they have MUI?). ESTEEM will provide the needed information to address these gaps.","text_display":" get a MUS if they have MUI?). ESTEEM will provide the needed information to address these gaps.","confidence":0.9990234375,"confidence_rate":0.999990229651252},{"cnt":[[271,1865],[1893,1865],[1893,1910],[271,1910]],"region":{"top_left_x":270,"top_left_y":1864,"width":1623,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e5da1ceb4bb474ca20481c4e7c88c3d","type":"text","conversion_output":true,"text":"Patients with MUI who ultimately elect surgery for SUI are often hopeful that their overall urinary","text_display":"\n\nPatients with MUI who ultimately elect surgery for SUI are often hopeful that their overall urinary","confidence":1,"confidence_rate":1},{"cnt":[[146,1910],[1835,1910],[1835,1953],[146,1953]],"region":{"top_left_x":146,"top_left_y":1909,"width":1689,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2500c3ca59f4b11a879023238fc601b","type":"text","conversion_output":true,"text":"condition will improve, but as surgeons we currently cannot assure patients this will be the outcome.","text_display":" condition will improve, but as surgeons we currently cannot assure patients this will be the outcome.","confidence":1,"confidence_rate":1},{"cnt":[[146,1953],[1899,1953],[1899,1996],[146,1996]],"region":{"top_left_x":146,"top_left_y":1952,"width":1754,"height":44},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a962fc1042514087a44a584cab1a50ed","type":"text","conversion_output":true,"text":"Treatments that can optimize both OAB and SUI outcomes in this population are needed. Studies have","text_display":" Treatments that can optimize both OAB and SUI outcomes in this population are needed. Studies have","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[146,1998],[1888,1998],[1888,2039],[146,2039]],"region":{"top_left_x":146,"top_left_y":1998,"width":1743,"height":41},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fab60354f5164fda97fae8aa604badfb","type":"text","conversion_output":true,"text":"demonstrated potential clinical benefit of initiating perioperative physical therapy after other procedures","text_display":" demonstrated potential clinical benefit of initiating perioperative physical therapy after other procedures","confidence":0.9990234375,"confidence_rate":0.999991276469766},{"cnt":[[146,2037],[1910,2037],[1910,2086],[146,2086]],"region":{"top_left_x":146,"top_left_y":2036,"width":1764,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f8f5f88cb974d1797ae1fa3cad4ff05","type":"text","conversion_output":true,"text":"including prostatectomy \\({ }^{38,39}\\) and orthopedic procedures \\({ }^{40}\\). Perioperative BPTx combined with MUS may","text_display":" including prostatectomy \\({ }^{38,39}\\) and orthopedic procedures \\({ }^{40}\\). Perioperative BPTx combined with MUS may","confidence":0.99560546875,"confidence_rate":0.9999650465189431},{"cnt":[[146,2084],[1916,2084],[1916,2129],[146,2129]],"region":{"top_left_x":146,"top_left_y":2083,"width":1771,"height":47},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"626cdc68722b4ffb9da8f7c37cdde6ca","type":"text","conversion_output":true,"text":"have similar effects on improving OAB outcomes in women with MUI. The index surgery may serve as a","text_display":" have similar effects on improving OAB outcomes in women with MUI. The index surgery may serve as a","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[146,2127],[1949,2127],[1949,2172],[146,2172]],"region":{"top_left_x":146,"top_left_y":2126,"width":1803,"height":47},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8d9693aacc34c75bf993d52ab8987fc","type":"text","conversion_output":true,"text":"\"teachable moment\" that can be used to reinforce principles and adherence of BPTx to optimize outcomes,","text_display":" \"teachable moment\" that can be used to reinforce principles and adherence of BPTx to optimize outcomes,","confidence":1,"confidence_rate":1},{"cnt":[[146,2172],[1760,2172],[1760,2215],[146,2215]],"region":{"top_left_x":146,"top_left_y":2172,"width":1614,"height":44},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7868efa022e048fbb89248fe4f2f1733","type":"text","conversion_output":true,"text":"and/or an opportunity to affect postoperative tissue remodeling and neuromuscular dysfunction.","text_display":" and/or an opportunity to affect postoperative tissue remodeling and neuromuscular dysfunction.","confidence":1,"confidence_rate":1},{"cnt":[[144,2256],[428,2256],[428,2301],[144,2301]],"region":{"top_left_x":143,"top_left_y":2255,"width":285,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"218581b697cd4582aadc2d5693a0b008","type":"section_header","conversion_output":false,"children_ids":["0858278e95004809aaf0659dbb0d5267"],"text":"","text_display":""},{"cnt":[[146,2260],[423,2260],[423,2297],[146,2297]],"region":{"top_left_x":146,"top_left_y":2260,"width":278,"height":37},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0858278e95004809aaf0659dbb0d5267","type":"text","conversion_output":true,"parent_id":"218581b697cd4582aadc2d5693a0b008","text":"2.10. Innovation","text_display":"\n\n\\subsection*{2.10. Innovation}","confidence":1,"confidence_rate":1},{"cnt":[[271,2312],[1966,2312],[1966,2357],[271,2357]],"region":{"top_left_x":270,"top_left_y":2311,"width":1696,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f63af28025e34f8f88323232034f66b7","type":"text","conversion_output":true,"text":"This proposal is innovative for several reasons. First, it studies a population of women who are often","text_display":"\n\nThis proposal is innovative for several reasons. First, it studies a population of women who are often","confidence":1,"confidence_rate":1},{"cnt":[[146,2357],[1931,2357],[1931,2400],[146,2400]],"region":{"top_left_x":146,"top_left_y":2356,"width":1786,"height":44},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c4d06bd0eca4963b5482deaae77bace","type":"text","conversion_output":true,"text":"excluded from clinical intervention trials but are at high risk for failing segregated SUI and UUI treatments.","text_display":" excluded from clinical intervention trials but are at high risk for failing segregated SUI and UUI treatments.","confidence":1,"confidence_rate":1},{"cnt":[[148,2400],[1927,2400],[1927,2443],[148,2443]],"region":{"top_left_x":148,"top_left_y":2399,"width":1780,"height":44},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf04da9114bf4545b1bda25eff38dc6d","type":"text","conversion_output":true,"text":"Second, in contrast to the historical paradigm of initiating treatments separately and stepwise for SUI and","text_display":" Second, in contrast to the historical paradigm of initiating treatments separately and stepwise for SUI and","confidence":0.998046875,"confidence_rate":0.9999825444841725},{"cnt":[[148,2445],[1897,2445],[1897,2488],[148,2488]],"region":{"top_left_x":148,"top_left_y":2444,"width":1750,"height":44},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20db02ef242b45d1a2d8f5bba39369a5","type":"text","conversion_output":true,"text":"UUI, we will evaluate the effect of a combined surgical and non-surgical approach to optimize treatment","text_display":" UUI, we will evaluate the effect of a combined surgical and non-surgical approach to optimize treatment","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[146,2488],[1949,2488],[1949,2533],[146,2533]],"region":{"top_left_x":146,"top_left_y":2487,"width":1803,"height":47},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94974259c36547deb6286d9a45a1eed0","type":"text","conversion_output":true,"text":"outcomes. Third, this study will provide critical information regarding OAB outcomes after MUS and will be","text_display":" outcomes. 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Finally, we will gain","text_display":"\npowered to allow reporting of OAB and SUI outcomes separately after treatment. Finally, we will gain","confidence":0.9326171875,"confidence_rate":0.9993358352730155},{"cnt":[[146,305],[1927,305],[1927,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1782,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4c24a81794d4929a6a1a5f6448f1b8f","type":"text","conversion_output":true,"text":"important predictive information regarding which patients may experience improvement, worsening, or no","text_display":" important predictive information regarding which patients may experience improvement, worsening, or no","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[1901,348],[1901,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1756,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc0efa539c824431b9c518267ee06cab","type":"text","conversion_output":true,"text":"change in their OAB symptoms. At the completion of this study, we will understand whether a combined","text_display":" change in their OAB symptoms. At the completion of this study, we will understand whether a combined","confidence":0.9990234375,"confidence_rate":0.9999906949037896},{"cnt":[[146,391],[1966,391],[1966,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1820,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88994afec3a04e0c878ba4bd0fb0658b","type":"text","conversion_output":true,"text":"behavioral/surgical treatment approach is superior to surgery alone and will have predictive information that","text_display":" behavioral/surgical treatment approach is superior to surgery alone and will have predictive information that","confidence":1,"confidence_rate":1},{"cnt":[[146,434],[1601,434],[1601,483],[146,483]],"region":{"top_left_x":146,"top_left_y":433,"width":1455,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca1a2fbe86a04606a87ad4dd1d42fc86","type":"text","conversion_output":true,"text":"will be directly applicable to the clinical care of patients with this challenging condition.","text_display":" will be directly applicable to the clinical care of patients with this challenging condition.","confidence":1,"confidence_rate":1},{"cnt":[[142,516],[483,516],[483,561],[142,561]],"region":{"top_left_x":141,"top_left_y":515,"width":343,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6e3f6fe481c4a1d90bbded87de9e3c2","type":"section_header","conversion_output":false,"children_ids":["86c7fd7b89b04e639d9bf185a33cb358"],"text":"","text_display":""},{"cnt":[[146,520],[483,520],[483,561],[146,561]],"region":{"top_left_x":146,"top_left_y":519,"width":338,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86c7fd7b89b04e639d9bf185a33cb358","type":"text","conversion_output":true,"parent_id":"c6e3f6fe481c4a1d90bbded87de9e3c2","text":"3. 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Description of study design (See Figure 2, Study flow diagram)}","confidence":0.99853515625,"confidence_rate":0.9999796402394503},{"cnt":[[799,705],[1326,705],[1326,750],[799,750]],"region":{"top_left_x":799,"top_left_y":704,"width":527,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0df32f7c571047248b17f485e6e072ec","type":"figure_label","conversion_output":false,"text":"Figure 2. Study flow diagram","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[387,784],[1594,784],[1594,2174],[387,2174]],"region":{"top_left_x":386,"top_left_y":784,"width":1209,"height":1391},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cea1d654cc174957b4b74efe84162d6a","type":"diagram","conversion_output":true,"selected_labels":["0df32f7c571047248b17f485e6e072ec"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 2. Study flow diagram}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/722dd686-9d24-4967-a9cf-6968feb8114e-14.jpg?height=1391&width=1209&top_left_y=784&top_left_x=386}\n\\end{figure}"},{"cnt":[[271,2209],[1906,2209],[1906,2254],[271,2254]],"region":{"top_left_x":270,"top_left_y":2208,"width":1636,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb7c97fbe3ee4a46a4197bc442da0f84","type":"text","conversion_output":true,"text":"ESTEEM is a 3 -stage, multi-center randomized trial of 472 women with MUI who have elected to","text_display":"\n\nESTEEM is a 3 -stage, multi-center randomized trial of 472 women with MUI who have elected to","confidence":0.9975595474243164,"confidence_rate":0.9999765057054769},{"cnt":[[146,2252],[1968,2252],[1968,2299],[146,2299]],"region":{"top_left_x":146,"top_left_y":2251,"width":1822,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9c46f912f8b44be9a7ce21711d47834","type":"text","conversion_output":true,"text":"undergo surgical treatment for SUI. Participants will be randomized to a peri-operative BPTx program+MUS","text_display":" undergo surgical treatment for SUI. Participants will be randomized to a peri-operative BPTx program+MUS","confidence":1,"confidence_rate":1},{"cnt":[[146,2297],[1863,2297],[1863,2344],[146,2344]],"region":{"top_left_x":146,"top_left_y":2296,"width":1717,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b262085dd83f49728384314190ad3d7e","type":"text","conversion_output":true,"text":"versus MUS alone. The purpose is to compare combined MUS+BPTx versus MUS alone (control) on","text_display":" versus MUS alone. The purpose is to compare combined MUS+BPTx versus MUS alone (control) on","confidence":1,"confidence_rate":1},{"cnt":[[146,2342],[752,2342],[752,2387],[146,2387]],"region":{"top_left_x":146,"top_left_y":2341,"width":606,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb3c6ccf5aaf4ef2a89fa0a76be2bb13","type":"text","conversion_output":true,"text":"improving MUI symptoms at 1 year.","text_display":" improving MUI symptoms at 1 year.","confidence":0.99853515625,"confidence_rate":0.9999642465493529},{"cnt":[[271,2385],[995,2385],[995,2430],[271,2430]],"region":{"top_left_x":270,"top_left_y":2384,"width":725,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea2d9b10a29240b89f14e0ce1b94ee55","type":"text","conversion_output":true,"text":"Stage 1: preoperative BPTx versus control","text_display":"\n\nStage 1: preoperative BPTx versus 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Masking issues","text_display":"\n\n\\subsection*{3.2 Masking issues}","confidence":1,"confidence_rate":1},{"cnt":[[271,314],[1968,314],[1968,359],[271,359]],"region":{"top_left_x":270,"top_left_y":313,"width":1698,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd269b48a8534a88b842dbe521fc5e4a","type":"text","conversion_output":true,"text":"It is not feasible to mask the patients or interventionists to the BPTx intervention due to the nature of","text_display":"\n\nIt is not feasible to mask the patients or interventionists to the BPTx intervention due to the nature of","confidence":1,"confidence_rate":1},{"cnt":[[146,357],[1910,357],[1910,402],[146,402]],"region":{"top_left_x":146,"top_left_y":356,"width":1764,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"badad023a995493eb0bee0cc41e4a540","type":"text","conversion_output":true,"text":"the treatment being studied. The team considered \"sham\" visits with interventionists; however, based on","text_display":" the treatment being studied. The team considered \"sham\" visits with interventionists; however, based on","confidence":1,"confidence_rate":1},{"cnt":[[146,402],[1914,402],[1914,445],[146,445]],"region":{"top_left_x":146,"top_left_y":401,"width":1769,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"247d4b435aa94ce8a512d53431eefc67","type":"text","conversion_output":true,"text":"expert interventionist opinion, sham interventions for UI involving the pelvic floor are extremely difficult to","text_display":" expert interventionist opinion, sham interventions for UI involving the pelvic floor are extremely difficult to","confidence":1,"confidence_rate":1},{"cnt":[[146,447],[1923,447],[1923,490],[146,490]],"region":{"top_left_x":146,"top_left_y":446,"width":1777,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd253a8cff5e4ee48cfb130c946c22a5","type":"text","conversion_output":true,"text":"design in a way that is convincing yet maintains the integrity of the intervention itself. We also considered","text_display":" design in a way that is convincing yet maintains the integrity of the intervention itself. We also considered","confidence":1,"confidence_rate":1},{"cnt":[[146,490],[1897,490],[1897,535],[146,535]],"region":{"top_left_x":146,"top_left_y":489,"width":1752,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a854ebdc2ccb47fe87d019297ae28148","type":"text","conversion_output":true,"text":"using \"general massage\" as a potential control group; however, there is some evidence suggesting that","text_display":" using \"general massage\" as a potential control group; however, there is some evidence suggesting that","confidence":1,"confidence_rate":1},{"cnt":[[146,533],[1974,533],[1974,578],[146,578]],"region":{"top_left_x":146,"top_left_y":532,"width":1829,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87026262f800471dbad73b488b6aa47a","type":"text","conversion_output":true,"text":"psychological stress is associated with OAB and irritative symptoms which could potentially contaminate the","text_display":" psychological stress is associated with OAB and irritative symptoms which could potentially contaminate the","confidence":0.80810546875,"confidence_rate":0.9980994627914141},{"cnt":[[146,576],[1852,576],[1852,621],[146,621]],"region":{"top_left_x":146,"top_left_y":575,"width":1706,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76ab0dafdd59421aa981d49de342792a","type":"text","conversion_output":true,"text":"control group. \\({ }^{41}\\) Issues of adherence (or over-adherence) in the massage group are also possible, as","text_display":" control group. \\({ }^{41}\\) Issues of adherence (or over-adherence) in the massage group are also possible, as","confidence":1,"confidence_rate":1},{"cnt":[[146,623],[1964,623],[1964,664],[146,664]],"region":{"top_left_x":146,"top_left_y":623,"width":1818,"height":41},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a22384b0a38245198df682ed8de8f5b1","type":"text","conversion_output":true,"text":"women could schedule these independently from the study. For these reasons, the team decided it was not","text_display":" women could schedule these independently from the study. 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All outcome","text_display":"\n\nStudy surgeons and outcome assessors will be masked to treatment assignment. All outcome","confidence":1,"confidence_rate":1},{"cnt":[[146,752],[1895,752],[1895,797],[146,797]],"region":{"top_left_x":146,"top_left_y":751,"width":1749,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f2339648fbf4cf88bca375cdd3c2504","type":"text","conversion_output":true,"text":"measures will be collected by masked outcome assessors. Study coordinators / clinical staff performing","text_display":" measures will be collected by masked outcome assessors. Study coordinators / clinical staff performing","confidence":1,"confidence_rate":1},{"cnt":[[146,797],[1955,797],[1955,842],[146,842]],"region":{"top_left_x":146,"top_left_y":797,"width":1810,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f1afebd039a4ce5b5ab5f17bf62aebe","type":"text","conversion_output":true,"text":"objective measurement of PFM strength will be masked (Aim 7). All patient-reported outcomes (PROs) will","text_display":" objective measurement of PFM strength will be masked (Aim 7). All patient-reported outcomes (PROs) will","confidence":1,"confidence_rate":1},{"cnt":[[146,842],[1265,842],[1265,887],[146,887]],"region":{"top_left_x":146,"top_left_y":842,"width":1120,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c72efbb74db46e587820bb9c00eada7","type":"text","conversion_output":true,"text":"be administered prior to other clinical assessments or procedures.","text_display":" be administered prior to other clinical assessments or procedures.","confidence":1,"confidence_rate":1},{"cnt":[[146,928],[672,928],[672,973],[146,973]],"region":{"top_left_x":146,"top_left_y":928,"width":527,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"866d6b72d6dc45bf91e92a2482a24990","type":"figure_label","conversion_output":false,"text":"Table 2. Masking in ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[125,1010],[904,1010],[904,1463],[125,1463]],"region":{"top_left_x":124,"top_left_y":1009,"width":781,"height":455},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7cbb3d5ab2d64cfabc931b3a5b7f047d","type":"table","conversion_output":true,"selected_labels":["866d6b72d6dc45bf91e92a2482a24990"],"text":"\\begin{tabular}{|l|l|}\n\\hline Study individual & Masking \\\\\n\\hline Study participant & No \\\\\n\\hline Interventionist & No \\\\\n\\hline \\begin{tabular}{l} \nOutcome assessors \\\\\n(includes clinical staff \\\\\nperforming PFM \\\\\nmeasurement)\n\\end{tabular} & Yes \\\\\n\\hline Study surgeon & Yes \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 2. Masking in ESTEEM}\n\\begin{tabular}{|l|l|}\n\\hline Study individual & Masking \\\\\n\\hline Study participant & No \\\\\n\\hline Interventionist & No \\\\\n\\hline \\begin{tabular}{l} \nOutcome assessors \\\\\n(includes clinical staff \\\\\nperforming PFM \\\\\nmeasurement)\n\\end{tabular} & Yes \\\\\n\\hline Study surgeon & Yes \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":1,"confidence_rate":1},{"cnt":[[271,1508],[1919,1508],[1919,1549],[271,1549]],"region":{"top_left_x":270,"top_left_y":1508,"width":1649,"height":42},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03805e15013d4765b4db64dc1d7292d7","type":"text","conversion_output":true,"text":"Efforts will be made by unmasked research assistant/staff members to remind the patient that the","text_display":"\n\nEfforts will be made by unmasked research assistant/staff members to remind the patient that the","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[146,1551],[1940,1551],[1940,1596],[146,1596]],"region":{"top_left_x":146,"top_left_y":1551,"width":1795,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40dabc87d2694330b5bdc5814e981dc8","type":"text","conversion_output":true,"text":"surgeon is masked to her treatment assignment. If she desires additional treatment, it is likely the surgeon","text_display":" surgeon is masked to her treatment assignment. If she desires additional treatment, it is likely the surgeon","confidence":1,"confidence_rate":1},{"cnt":[[146,1594],[1904,1594],[1904,1635],[146,1635]],"region":{"top_left_x":146,"top_left_y":1594,"width":1758,"height":41},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9df437348e8140f59120829c8211b624","type":"text","conversion_output":true,"text":"would offer BPTx as additional treatment and she will be reminded that she can decline additional BPTx","text_display":" would offer BPTx as additional treatment and she will be reminded that she can decline additional BPTx","confidence":1,"confidence_rate":1},{"cnt":[[146,1637],[1828,1637],[1828,1682],[146,1682]],"region":{"top_left_x":146,"top_left_y":1637,"width":1683,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba7d28c403c0403b99c702279d7e2e43","type":"text","conversion_output":true,"text":"without revealing to her surgeon that she received the BPTx intervention. Such methods have been","text_display":" without revealing to her surgeon that she received the BPTx intervention. Such methods have been","confidence":1,"confidence_rate":1},{"cnt":[[146,1680],[1025,1680],[1025,1725],[146,1725]],"region":{"top_left_x":146,"top_left_y":1680,"width":879,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ad7893e035b46fa8412c8f8c017261b","type":"text","conversion_output":true,"text":"effective for past PFDN trials (e.g. OPTIMAL trial \\({ }^{42}\\) ).","text_display":" effective for past PFDN trials (e.g. OPTIMAL trial \\({ }^{42}\\) ).","confidence":0.9975595474243164,"confidence_rate":0.9999655860100072},{"cnt":[[144,1766],[780,1766],[780,1811],[144,1811]],"region":{"top_left_x":143,"top_left_y":1766,"width":637,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"856e79f70ed647d1bf19948691734ca1","type":"section_header","conversion_output":false,"children_ids":["0b096a8ee8e14d6bb000ff886c611ec9"],"text":"","text_display":""},{"cnt":[[146,1766],[780,1766],[780,1807],[146,1807]],"region":{"top_left_x":146,"top_left_y":1766,"width":634,"height":41},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b096a8ee8e14d6bb000ff886c611ec9","type":"text","conversion_output":true,"parent_id":"856e79f70ed647d1bf19948691734ca1","text":"3.3. Randomization and Stratification","text_display":"\n\n\\subsection*{3.3. Randomization and Stratification}","confidence":0.99951171875,"confidence_rate":0.9999883714843234},{"cnt":[[271,1822],[1824,1822],[1824,1867],[271,1867]],"region":{"top_left_x":270,"top_left_y":1821,"width":1555,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cf4b8baf517465d93a7ca757150b9d6","type":"text","conversion_output":true,"text":"Patients will be assigned to one of the two treatment groups with a randomization sequence","text_display":"\n\nPatients will be assigned to one of the two treatment groups with a randomization sequence","confidence":1,"confidence_rate":1},{"cnt":[[146,1865],[1876,1865],[1876,1910],[146,1910]],"region":{"top_left_x":146,"top_left_y":1864,"width":1730,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d50be43ef95d4914bba8e71be1853b70","type":"text","conversion_output":true,"text":"prepared and maintained centrally by the Data Coordinating Center (DCC). Allocation to the treatment","text_display":" prepared and maintained centrally by the Data Coordinating Center (DCC). Allocation to the treatment","confidence":1,"confidence_rate":1},{"cnt":[[146,1910],[1893,1910],[1893,1953],[146,1953]],"region":{"top_left_x":146,"top_left_y":1909,"width":1747,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"207af8d380b44e19849c0ea902406c17","type":"text","conversion_output":true,"text":"groups will be \\(1: 1\\). Randomly ordered permuted blocks will be used, with block sizes known only by the","text_display":" groups will be \\(1: 1\\). Randomly ordered permuted blocks will be used, with block sizes known only by the","confidence":0.7255400104913861,"confidence_rate":0.9970875307703617},{"cnt":[[146,1953],[1949,1953],[1949,1998],[146,1998]],"region":{"top_left_x":146,"top_left_y":1952,"width":1803,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9011f9f2ba614840ac7ab5faaef676a4","type":"text","conversion_output":true,"text":"DCC. The web-based data management system will provide the treatment assignment for each participant","text_display":" DCC. The web-based data management system will provide the treatment assignment for each participant","confidence":1,"confidence_rate":1},{"cnt":[[146,1998],[1717,1998],[1717,2041],[146,2041]],"region":{"top_left_x":146,"top_left_y":1998,"width":1571,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"759a0224eaa3440780569fa137851ed6","type":"text","conversion_output":true,"text":"as she is randomized. Thus, the allocation sequence will be concealed from clinical site staff.","text_display":" as she is randomized. Thus, the allocation sequence will be concealed from clinical site staff.","confidence":1,"confidence_rate":1},{"cnt":[[271,2041],[1910,2041],[1910,2086],[271,2086]],"region":{"top_left_x":270,"top_left_y":2041,"width":1640,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea0b7f44f9184b93b9aeefaac1c9211e","type":"text","conversion_output":true,"text":"Randomization will be stratified by clinical site. It is important that UUI \"severity\" is comparable in","text_display":"\n\nRandomization will be stratified by clinical site. It is important that UUI \"severity\" is comparable in","confidence":1,"confidence_rate":1},{"cnt":[[146,2084],[1824,2084],[1824,2129],[146,2129]],"region":{"top_left_x":146,"top_left_y":2083,"width":1679,"height":47},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0099f6930ca64a1f856d1fc5a0946324","type":"text","conversion_output":true,"text":"both groups as it is a potential risk factor for treatment failure. Therefore, randomization will also be","text_display":" both groups as it is a potential risk factor for treatment failure. Therefore, randomization will also be","confidence":1,"confidence_rate":1},{"cnt":[[146,2129],[1867,2129],[1867,2174],[146,2174]],"region":{"top_left_x":146,"top_left_y":2129,"width":1721,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a42b96cf2c2943d78bf134e58446dbae","type":"text","conversion_output":true,"text":"stratified based on UUI \"severity\" which will be defined by the number of urgency urinary incontinence","text_display":" stratified based on UUI \"severity\" which will be defined by the number of urgency urinary incontinence","confidence":1,"confidence_rate":1},{"cnt":[[146,2174],[1906,2174],[1906,2219],[146,2219]],"region":{"top_left_x":146,"top_left_y":2174,"width":1760,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eec269279ff54858810fdcf4581f0f91","type":"text","conversion_output":true,"text":"episodes (IEs) on diary. This will ensure that women who have more frequent, or more \"severe\" UUI are","text_display":" episodes (IEs) on diary. This will ensure that women who have more frequent, or more \"severe\" UUI are","confidence":1,"confidence_rate":1},{"cnt":[[146,2217],[1888,2217],[1888,2262],[146,2262]],"region":{"top_left_x":146,"top_left_y":2217,"width":1743,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76d981e38fc547d3bf8abba6cf87f1e4","type":"text","conversion_output":true,"text":"equally distributed between the two groups. SUI severity is less of an issue because all subjects will be","text_display":" equally distributed between the two groups. SUI severity is less of an issue because all subjects will be","confidence":1,"confidence_rate":1},{"cnt":[[146,2260],[784,2260],[784,2305],[146,2305]],"region":{"top_left_x":146,"top_left_y":2260,"width":639,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45d3667871674a94a2949c8a59dd5354","type":"text","conversion_output":true,"text":"receiving the same treatment for SUI.","text_display":" receiving the same treatment for SUI.","confidence":1,"confidence_rate":1},{"cnt":[[271,2303],[1957,2303],[1957,2348],[271,2348]],"region":{"top_left_x":270,"top_left_y":2303,"width":1688,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a7eaa5dba25419a898f2e1b54c9ab68","type":"text","conversion_output":true,"text":"Burgio et al, \\({ }^{43}\\) identified risk factors for unsuccessful behavioral treatment of urge/urge-predominant","text_display":"\n\nBurgio et al, \\({ }^{43}\\) identified risk factors for unsuccessful behavioral treatment of urge/urge-predominant","confidence":1,"confidence_rate":1},{"cnt":[[146,2350],[1807,2350],[1807,2396],[146,2396]],"region":{"top_left_x":146,"top_left_y":2350,"width":1661,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71c9b861b9e54f7197933ed4a7a2f827","type":"text","conversion_output":true,"text":"MUI. Women who had \\(\\geq 10 IE /\\) week on a 7 -day diary diary at baseline were much less likely to be","text_display":" MUI. Women who had \\(\\geq 10 IE /\\) week on a 7 -day diary diary at baseline were much less likely to be","confidence":0.9781920951834666,"confidence_rate":0.9997958614697404},{"cnt":[[146,2393],[1972,2393],[1972,2438],[146,2438]],"region":{"top_left_x":146,"top_left_y":2393,"width":1827,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be3dfaca591d4239b311ffefec5d0d77","type":"text","conversion_output":true,"text":"completely continent after behavioral treatment. Therefore, for a 3 -day diary, this would translate into \\(\\sim 4\\) IEs","text_display":" completely continent after behavioral treatment. Therefore, for a 3 -day diary, this would translate into \\(\\sim 4\\) IEs","confidence":0.8582594394683838,"confidence_rate":0.9987580982364741},{"cnt":[[146,2436],[1192,2436],[1192,2481],[146,2481]],"region":{"top_left_x":146,"top_left_y":2436,"width":1047,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"625c067f3f514116899e3e7955f6f251","type":"text","conversion_output":true,"text":"on a 3 -day diary as a potential risk factor for treatment failure.","text_display":" on a 3 -day diary as a potential risk factor for treatment failure.","confidence":0.5,"confidence_rate":0.9908006132652293},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2749013718b54e679e91f9557e6be343","type":"page_info","conversion_output":false,"text":"15","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d43cedc1cca147ea9e4fc2461c25456f","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-16","page":16,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55549662c08b4f47bc834c911552d3f0","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c23d8f57a1e545a28ee10376b806463f","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74648f6ed1b547d591a237d3ba099c6b","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,256],[146,256]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbbcfa6963e14f6cb29c5167d8f9ab44","type":"section_header","conversion_output":false,"children_ids":["ceca6932a6804ab4925f63077e0f4c12"],"text":"","text_display":""},{"cnt":[[148,217],[354,217],[354,251],[148,251]],"region":{"top_left_x":148,"top_left_y":216,"width":207,"height":36},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ceca6932a6804ab4925f63077e0f4c12","type":"text","conversion_output":true,"parent_id":"cbbcfa6963e14f6cb29c5167d8f9ab44","text":"Confidential","text_display":"\n\n\\section*{Confidential}","confidence":1,"confidence_rate":1},{"cnt":[[271,262],[1934,262],[1934,303],[271,303]],"region":{"top_left_x":270,"top_left_y":262,"width":1664,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b55209ad58d4f338187a008c42eb963","type":"text","conversion_output":true,"text":"There is limited data to support stratification based on presence of preoperative DO on UDE. One","text_display":"\n\nThere is limited data to support stratification based on presence of preoperative DO on UDE. One","confidence":1,"confidence_rate":1},{"cnt":[[146,303],[1957,303],[1957,346],[146,346]],"region":{"top_left_x":146,"top_left_y":302,"width":1812,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64d5f5a4150243c98efad2df14ba8931","type":"text","conversion_output":true,"text":"study found that up to \\(38 \\%\\) will have resolution of DO after MUS. \\({ }^{44}\\) Other studies suggest that baseline DO","text_display":" study found that up to \\(38 \\%\\) will have resolution of DO after MUS. \\({ }^{44}\\) Other studies suggest that baseline DO","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[1940,348],[1940,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1795,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"501b8d02746048a9a86dfa82105c14e6","type":"text","conversion_output":true,"text":"is a risk factor for postoperative UUI. \\({ }^{45}\\) Still other studies even suggest that baseline DO is associated with","text_display":" is a risk factor for postoperative UUI. \\({ }^{45}\\) Still other studies even suggest that baseline DO is associated with","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1906,391],[1906,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1760,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12d889387dcc41978962adc823fb2e09","type":"text","conversion_output":true,"text":"greater improvement in OAB symptoms postoperatively. Choe et al evaluated 132 women with MUI who","text_display":" greater improvement in OAB symptoms postoperatively. Choe et al evaluated 132 women with MUI who","confidence":0.9970703125,"confidence_rate":0.9999717889802962},{"cnt":[[146,436],[1944,436],[1944,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1799,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26723db7079040968cc626b2a67d0223","type":"text","conversion_output":true,"text":"underwent MUS and found a higher proportion of women with preoperative DO had complete resolution of","text_display":" underwent MUS and found a higher proportion of women with preoperative DO had complete resolution of","confidence":1,"confidence_rate":1},{"cnt":[[146,477],[1927,477],[1927,522],[146,522]],"region":{"top_left_x":146,"top_left_y":476,"width":1782,"height":47},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65b3e0c76ec44326b99ca78a9d115185","type":"text","conversion_output":true,"text":"OAB symptoms postoperatively compared to those without DO ( \\(37 \\% vs .18 \\%) .{ }^{46} A\\) secondary analysis of","text_display":" OAB symptoms postoperatively compared to those without DO ( \\(37 \\% vs .18 \\%) .{ }^{46} A\\) secondary analysis of","confidence":0.5357079170972076,"confidence_rate":0.9946794507062575},{"cnt":[[146,524],[1927,524],[1927,569],[146,569]],"region":{"top_left_x":146,"top_left_y":524,"width":1782,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f257aac474b44dfdb133e865940a938f","type":"text","conversion_output":true,"text":"TOMUS data supported that more severe UUI (by MESA score) was a risk factor for non-SUI sling failure","text_display":" TOMUS data supported that more severe UUI (by MESA score) was a risk factor for non-SUI sling failure","confidence":1,"confidence_rate":1},{"cnt":[[146,567],[1876,567],[1876,612],[146,612]],"region":{"top_left_x":146,"top_left_y":567,"width":1730,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c781d8d93bdb4768ba19f59680e085d9","type":"text","conversion_output":true,"text":"after MUS (or failure due to UUI); \\({ }^{29}\\) however, baseline DO was not a risk factor ( \\(28 \\%\\) vs \\(21 \\%\\) objective","text_display":" after MUS (or failure due to UUI); \\({ }^{29}\\) however, baseline DO was not a risk factor ( \\(28 \\%\\) vs \\(21 \\%\\) objective","confidence":0.9970715045928955,"confidence_rate":0.9999763487325998},{"cnt":[[146,610],[1072,610],[1072,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":927,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"def9fa54dc994d608cf0e55fb1799e75","type":"text","conversion_output":true,"text":"failure for women with and without DO, respectively). \\({ }^{30}\\)","text_display":" failure for women with and without DO, respectively). \\({ }^{30}\\)","confidence":1,"confidence_rate":1},{"cnt":[[271,655],[1970,655],[1970,698],[271,698]],"region":{"top_left_x":270,"top_left_y":655,"width":1701,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b16397b9220a499aa7a75a8d52d14066","type":"text","conversion_output":true,"text":"Based on the existing evidence, the team reached consensus that women should be stratified based","text_display":"\n\nBased on the existing evidence, the team reached consensus that women should be stratified based","confidence":1,"confidence_rate":1},{"cnt":[[146,700],[1854,700],[1854,741],[146,741]],"region":{"top_left_x":146,"top_left_y":700,"width":1709,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d79dcb58cac4a69b7a60a3676b5ad3d","type":"text","conversion_output":true,"text":"on a cutoff of \\(\\geq 4\\) urge IEs on 3-day diary. The team agreed that there was insufficient data regarding","text_display":" on a cutoff of \\(\\geq 4\\) urge IEs on 3-day diary. 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Detailed Description of Primary Study Outcome}","confidence":1,"confidence_rate":1},{"cnt":[[271,1861],[1914,1861],[1914,1904],[271,1904]],"region":{"top_left_x":270,"top_left_y":1860,"width":1645,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"917c2b0b64f14929a31e901cb607e397","type":"text","conversion_output":true,"text":"The primary outcome for this study is the mean change from baseline in UDI-total score at 1 year","text_display":"\n\nThe primary outcome for this study is the mean change from baseline in UDI-total score at 1 year","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[146,1904],[1974,1904],[1974,1949],[146,1949]],"region":{"top_left_x":146,"top_left_y":1903,"width":1829,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"596b7b3901374dfea2538ff2c1289d32","type":"text","conversion_output":true,"text":"postoperative. 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Criterion validity was established by correlating total and subscale scores with","text_display":" diary and pad tests. Criterion validity was established by correlating total and subscale scores with","confidence":1,"confidence_rate":1},{"cnt":[[146,2299],[1962,2299],[1962,2344],[146,2344]],"region":{"top_left_x":146,"top_left_y":2298,"width":1816,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa4fc90aeb904f3db06acbf5d712a3cb","type":"text","conversion_output":true,"text":"physician diagnoses. The UDI can effectively discriminate between known UI clinical groups and diagnoses","text_display":" physician diagnoses. The UDI can effectively discriminate between known UI clinical groups and diagnoses","confidence":1,"confidence_rate":1},{"cnt":[[146,2342],[1936,2342],[1936,2387],[146,2387]],"region":{"top_left_x":146,"top_left_y":2341,"width":1790,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24b7c12ac9734fa38656b39a4b7c0e63","type":"text","conversion_output":true,"text":"(specifically genuine SUI, urodynamic detrusor overactivity, or mixed) and is responsive to change. These","text_display":" (specifically genuine SUI, urodynamic detrusor overactivity, or mixed) and is responsive to change. These","confidence":1,"confidence_rate":1},{"cnt":[[146,2389],[1588,2389],[1588,2430],[146,2430]],"region":{"top_left_x":146,"top_left_y":2389,"width":1442,"height":41},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4faef20b1971400baeb9ebbb5cb56afd","type":"text","conversion_output":true,"text":"are some minimum qualities needed for valid interpretation of a PRO in a clinical trial.","text_display":" are some minimum qualities needed for valid interpretation of a PRO in a clinical trial.","confidence":0.99560546875,"confidence_rate":0.9999526439645051},{"cnt":[[271,2432],[1931,2432],[1931,2477],[271,2477]],"region":{"top_left_x":270,"top_left_y":2432,"width":1662,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68d17debbff8402094e258e2b576166f","type":"text","conversion_output":true,"text":"Although it is fairly simple to determine the statistical significance of a change in a symptom index,","text_display":"\n\nAlthough it is fairly simple to determine the statistical significance of a change in a symptom index,","confidence":1,"confidence_rate":1},{"cnt":[[146,2475],[1897,2475],[1897,2520],[146,2520]],"region":{"top_left_x":146,"top_left_y":2475,"width":1752,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"567de9a1aa984a128b5bac0764f0ed44","type":"text","conversion_output":true,"text":"placing the magnitude of these changes in a context that is meaningful for patients is more difficult. The","text_display":" placing the magnitude of these changes in a context that is meaningful for patients is more difficult. The","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77cfab50a241414eac76740248293da9","type":"page_info","conversion_output":false,"text":"16","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2884a79deb8c4aeeb4bac5d81f2b8f30","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-17","page":17,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c5e2469b58c4be1a8751da06b5fb0fa","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75f5de35280f45c19189c3d901a83010","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0611d5d344bd4470b8144a661af74e9a","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,254],[146,254]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":40},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09b479d04dfa407593a8d40f40e05bc1","type":"text","conversion_output":true,"text":"Confidential","text_display":"\n\nConfidential","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1807,260],[1807,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1661,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51783342997c4847af33a8f0e047f92c","type":"text","conversion_output":true,"text":"minimum important difference (MID) of a measure is a score change that should reflect a clinically","text_display":"\nminimum important difference (MID) of a measure is a score change that should reflect a clinically","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1893,305],[1893,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1747,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ead779db609421d98427668ef3ffb7e","type":"text","conversion_output":true,"text":"meaningful response to treatment and represents the \"between group criterion\" that needs to be met or","text_display":" meaningful response to treatment and represents the \"between group criterion\" that needs to be met or","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[1897,348],[1897,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1752,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"419b9d9782d74df9b8d5b999d5b30432","type":"text","conversion_output":true,"text":"exceeded in order for study results to be considered clinically meaningful. From the patient perspective,","text_display":" exceeded in order for study results to be considered clinically meaningful. From the patient perspective,","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1962,391],[1962,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1816,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1e582ece455425e85c72db052f49c5b","type":"text","conversion_output":true,"text":"MID can be defined as \"the smallest difference in score in the domain of interest which patients perceive as","text_display":" MID can be defined as \"the smallest difference in score in the domain of interest which patients perceive as","confidence":1,"confidence_rate":1},{"cnt":[[146,434],[1897,434],[1897,479],[146,479]],"region":{"top_left_x":146,"top_left_y":433,"width":1752,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de189c9351d841c897eaf19387c65b7f","type":"text","conversion_output":true,"text":"beneficial...\" \\({ }^{49}\\) It is useful for interpreting questionnaire results for both within-group and between-group","text_display":" beneficial...\" \\({ }^{49}\\) It is useful for interpreting questionnaire results for both within-group and between-group","confidence":1,"confidence_rate":1},{"cnt":[[146,479],[1927,479],[1927,522],[146,522]],"region":{"top_left_x":146,"top_left_y":479,"width":1782,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74e156730c694c21bba6d8ad2fa88dff","type":"text","conversion_output":true,"text":"differences and represents the magnitude of benefit for which trials should be powered to minimize type 1","text_display":" differences and represents the magnitude of benefit for which trials should be powered to minimize type 1","confidence":1,"confidence_rate":1},{"cnt":[[146,524],[1966,524],[1966,569],[146,569]],"region":{"top_left_x":146,"top_left_y":524,"width":1820,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f2df37bc89044c7aaa3b1e68955aded","type":"text","conversion_output":true,"text":"and type 2 errors. Although no single approach to determine MID is perfect, a combination of approaches is","text_display":" and type 2 errors. Although no single approach to determine MID is perfect, a combination of approaches is","confidence":1,"confidence_rate":1},{"cnt":[[146,567],[1964,567],[1964,612],[146,612]],"region":{"top_left_x":146,"top_left_y":567,"width":1818,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"717909400ce946e2a63bd57a5e4be393","type":"text","conversion_output":true,"text":"often used to determine a reasonable range of MID scores. Importantly, there are published MID ranges for","text_display":" often used to determine a reasonable range of MID scores. Importantly, there are published MID ranges for","confidence":1,"confidence_rate":1},{"cnt":[[146,610],[1876,610],[1876,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1730,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb550427c03b494c9951e636092fdeab","type":"text","conversion_output":true,"text":"the total UDI score and its subscales for urge predominant and pure stress/stress predominant urinary","text_display":" the total UDI score and its subscales for urge predominant and pure stress/stress predominant urinary","confidence":1,"confidence_rate":1},{"cnt":[[146,653],[582,653],[582,698],[146,698]],"region":{"top_left_x":146,"top_left_y":653,"width":437,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d8646ba662542eeb1d5c9a1b5beb50f","type":"text","conversion_output":true,"text":"incontinence populations.","text_display":" incontinence populations.","confidence":1,"confidence_rate":1},{"cnt":[[271,698],[1953,698],[1953,741],[271,741]],"region":{"top_left_x":270,"top_left_y":698,"width":1683,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a551fbf4a86a4dbfa3a93048c339f7bd","type":"text","conversion_output":true,"text":"Table 3 summarizes the relevant published MID data for the UDI. Dyer et al used the BE-DRI study","text_display":"\n\nTable 3 summarizes the relevant published MID data for the UDI. Dyer et al used the BE-DRI study","confidence":1,"confidence_rate":1},{"cnt":[[146,743],[1858,743],[1858,786],[146,786]],"region":{"top_left_x":146,"top_left_y":743,"width":1713,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94113fff05f14ae09604b75075e2a741","type":"text","conversion_output":true,"text":"population to determine MID values for the UDI and UDI-irritative subscale. \\({ }^{50}\\) The BE-DRI population","text_display":" population to determine MID values for the UDI and UDI-irritative subscale. \\({ }^{50}\\) The BE-DRI population","confidence":1,"confidence_rate":1},{"cnt":[[146,786],[1931,786],[1931,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1786,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89235d9a52944d42b51ca1e4a2bc8e09","type":"text","conversion_output":true,"text":"included 94\\% subjects with urge-predominant MUI based on bladder diary with a baseline mean UDI total","text_display":" included 94\\% subjects with urge-predominant MUI based on bladder diary with a baseline mean UDI total","confidence":0.53125,"confidence_rate":0.9940505743914622},{"cnt":[[146,829],[1940,829],[1940,874],[146,874]],"region":{"top_left_x":146,"top_left_y":829,"width":1795,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f35efab1b19c4193b8afda76ec98f4b5","type":"text","conversion_output":true,"text":"score of 120 ( 49 ) points and UDI-irritative subscale score of 58 ( 22 ) points. Using anchor based methods,","text_display":" score of 120 ( 49 ) points and UDI-irritative subscale score of 58 ( 22 ) points. Using anchor based methods,","confidence":0.750529707886383,"confidence_rate":0.997725004079468},{"cnt":[[146,872],[1876,872],[1876,917],[146,917]],"region":{"top_left_x":146,"top_left_y":872,"width":1730,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39d8a662c96f4fb28a6a22543223a873","type":"text","conversion_output":true,"text":"the authors recommend an MID of - 35 for total UDI and - 15 for UDI-irritative scores for this population.","text_display":" the authors recommend an MID of - 35 for total UDI and - 15 for UDI-irritative scores for this population.","confidence":0.5333743679326524,"confidence_rate":0.9946423377380716},{"cnt":[[271,920],[1957,920],[1957,965],[271,965]],"region":{"top_left_x":270,"top_left_y":919,"width":1688,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14e9ec81568f43e48cdbfbde5bda8308","type":"text","conversion_output":true,"text":"Barber et al used the Ambulatory Treatments for Leakage Associated with Stress Incontinence Trial","text_display":"\n\nBarber et al used the Ambulatory Treatments for Leakage Associated with Stress Incontinence Trial","confidence":1,"confidence_rate":1},{"cnt":[[146,958],[1919,958],[1919,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":958,"width":1773,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"097d59232c1f4d1e91cc2ebf013ba91d","type":"text","conversion_output":true,"text":"(ATLAS) study population and determined MID values for the UDI total and UDI-stress subscales. \\({ }^{51}\\) This","text_display":" (ATLAS) study population and determined MID values for the UDI total and UDI-stress subscales. \\({ }^{51}\\) This","confidence":1,"confidence_rate":1},{"cnt":[[146,1005],[1893,1005],[1893,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1005,"width":1747,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdf4d9194b004395b342274e9288eb78","type":"text","conversion_output":true,"text":"population was pure/stress-predominant MUI, undergoing conservative treatment for SUI. The baseline","text_display":" population was pure/stress-predominant MUI, undergoing conservative treatment for SUI. The baseline","confidence":1,"confidence_rate":1},{"cnt":[[146,1051],[1968,1051],[1968,1096],[146,1096]],"region":{"top_left_x":146,"top_left_y":1050,"width":1822,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"152e77fab2f447ffb24e28202c058c73","type":"text","conversion_output":true,"text":"mean UDI score was lower at 80 (40) points and UDI-stress was 47 (19) points. Based on their findings, the","text_display":" mean UDI score was lower at 80 (40) points and UDI-stress was 47 (19) points. Based on their findings, the","confidence":0.46274436463136226,"confidence_rate":0.9934354830353158},{"cnt":[[146,1096],[1824,1096],[1824,1141],[146,1141]],"region":{"top_left_x":146,"top_left_y":1095,"width":1679,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c5ebb2bbc684f9fb285e85eef12d47a","type":"text","conversion_output":true,"text":"authors recommend an MID of -11 and -8 for the UDI total and stress subscale scores respectively.","text_display":" authors recommend an MID of -11 and -8 for the UDI total and stress subscale scores respectively.","confidence":0.9736578403972089,"confidence_rate":0.9997528515620953},{"cnt":[[271,1182],[1390,1182],[1390,1227],[271,1227]],"region":{"top_left_x":270,"top_left_y":1181,"width":1121,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efc932a1c0394298a050192c72eada35","type":"figure_label","conversion_output":false,"text":"Table 3. Published MIDs for the Urogenital Distress Inventory","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[116,1263],[2060,1263],[2060,1723],[116,1723]],"region":{"top_left_x":116,"top_left_y":1263,"width":1945,"height":461},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29b18a9014954177b854682a815ae9a6","type":"table","conversion_output":true,"children_ids":["b6f9772c254e4c92b4eb1c66149f07ed","1c834e90de77410181452fe83634d69f","ddfd26d25435400a924b5fd595e65697","128dac6f0a7b4c149083061afea280ca","56ca04ebe7c74a58b02f445b5edb60ea","01dfd238bc614a85b9385773d982f5ca","505df735aaa241b3b6fab8ef2fbd80eb","66c646c5e26a435f90e55c75cc3a1aa8","f15e9494188d4f86ac36850017befa4b","2dd103efd218402ab49a74cb4faf483e","87d6c071bfa447a0a319f1f1db3a0718","cbbced1230124f388113ec028f88cb98","e8c8af1edf974ca298234cb796035517","fbf9a3e3717746158fac64eca7f5f5e2","4abe07689bbf409d80d0aa5975b0e1e4","f44eb2d8d98648a4b1fd500c540bb1fb","e7bd069fc81a452996f1b8f6f05d2925","2287dce6b6c74ae9aedf76baaa46ba54","f2f0225ab4f14199a3f4d2d345b4873d","bb073f6971014e629f6218906d47b670","a216f72038b84a9381c1944a968f85cd","1087085b52e44ca3a7f2481fd2a01ba0","11261b3b79554c298c43599057a7f406","40798c241c3143c9bcc7fad69b2c27b3","e05cecda48884fe5866957d497e78133","a3182fd5b6b1402e9af6d5d54fc5bc21","fe7464908724496a9a695fe0889b2df3","b525e6a0e8c542a1a7abe17a8c04ea49","c023acbe9fde420fb2960e3549df9239","3b2bbd341c1849ad935047bbd7840a96","232e4e4cff7c4a628dc3f45a8f496d23","c2234f9646ba4133b71b7d5b2c3f2669","7adf08242522481c9da5a8929a5ee7c6","9e760025d43649c499088fc57519a823","9c8bf0da22144f1cb26f8d0bd3ec503f","1fd558001ae64551bfe443abc366883b","9bfe6e01007a4f0396e688e7b36d56e9","fe5f491b8d7549fbaa19e615ce8ee30a","666fe77175c34ed9aa0841c5bcd1914d","a7baad6f3ac9431d987c51a03639eb51","80c4461fc56e4c25af5db62990d10c02"],"selected_labels":["efc932a1c0394298a050192c72eada35"],"text":"\\begin{tabular}{|l|l|l|l|l|l|l|}\n\\hline Trial/Author & Population & Endpoint/ intervention & UDI component & Anchor-based MID & Distributionbased MID (1/2 SD) & Recommended MID \\\\\n\\hline \\multirow[t]{2}{*}{BE-DRI, Dyer \\({ }^{50}\\)} & \\multirow[t]{2}{*}{Pure urge/Urgepredominant MUI} & \\multirow{2}{*}{8 month Meds +/BPTx} & UDI-total & -45 to -36 & -25 & -35 \\\\\n\\hline & & & UDI-irritative & -20 to -18 & -11 & -15 \\\\\n\\hline \\multirow[t]{2}{*}{ATLAS, Barber \\({ }^{51}\\)} & \\multirow[t]{2}{*}{Pure SUI/SUI predominant MUI} & \\multirow{2}{*}{3 month Pessary vs BPTx vs both} & UDI-total & -22.6 to -6.4 & -21.9 to -18.8 & -11 \\\\\n\\hline & & & UDI-stress & -16.5 to -4.6 & -10.6 to -9.1 & -8 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3. 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at","text_display":"\n\nPublished MIDs are important for estimating sample size and interpreting findings, however there are at","confidence":1,"confidence_rate":1},{"cnt":[[146,1852],[1059,1852],[1059,1897],[146,1897]],"region":{"top_left_x":146,"top_left_y":1851,"width":914,"height":47},"line":100,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8cd7c1af6f84320924963ed13d410aa","type":"text","conversion_output":true,"text":"least 3 different ways we can analyze the UDI scores:","text_display":" least 3 different ways we can analyze the UDI scores:","confidence":1,"confidence_rate":1},{"cnt":[[271,1899],[1489,1899],[1489,1944],[271,1944]],"region":{"top_left_x":270,"top_left_y":1899,"width":1219,"height":46},"line":101,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da2083a1e3a54cfb8ff9af4f56c79207","type":"text","conversion_output":true,"text":"\\#1. Compare postoperative mean UDI scores between groups at 1 year","text_display":"\n\\#1. Compare postoperative mean UDI scores between groups at 1 year","confidence":0.99951171875,"confidence_rate":0.9999934000150488},{"cnt":[[271,1942],[1803,1942],[1803,1987],[271,1987]],"region":{"top_left_x":270,"top_left_y":1942,"width":1533,"height":46},"line":102,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc7baf4b1b1040e7b56dcff23ba6d3f1","type":"text","conversion_output":true,"text":"\\#2. Compare mean changes (delta) in UDI scores from baseline to 1 -year between groups","text_display":"\n\\#2. Compare mean changes (delta) in UDI scores from baseline to 1 -year between groups","confidence":0.8448774446733296,"confidence_rate":0.9982083760476198},{"cnt":[[271,1985],[651,1985],[651,2030],[271,2030]],"region":{"top_left_x":270,"top_left_y":1985,"width":381,"height":46},"line":103,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91d4c785b4dc49c787b13da3a200f3e4","type":"text","conversion_output":true,"text":"(preferred, see below)","text_display":" (preferred, see below)","confidence":1,"confidence_rate":1},{"cnt":[[271,2030],[1901,2030],[1901,2075],[271,2075]],"region":{"top_left_x":270,"top_left_y":2030,"width":1632,"height":46},"line":104,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e59bff39b994644b703a0435637f2f1","type":"text","conversion_output":true,"text":"\\#3. Dichotomize \"success\" and \"failure\" as women who achieved a 35 point improvement versus","text_display":"\n\\#3. Dichotomize \"success\" and \"failure\" as women who achieved a 35 point improvement versus","confidence":1,"confidence_rate":1},{"cnt":[[271,2073],[1214,2073],[1214,2121],[271,2121]],"region":{"top_left_x":270,"top_left_y":2073,"width":944,"height":48},"line":105,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22b55072a1824e65947ccad240d56157","type":"text","conversion_output":true,"text":"those who did not (also known as \"responder analysis\")","text_display":" those who did not (also known as \"responder analysis\")","confidence":1,"confidence_rate":1},{"cnt":[[271,2161],[1936,2161],[1936,2206],[271,2206]],"region":{"top_left_x":270,"top_left_y":2161,"width":1666,"height":46},"line":106,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c02fd51410c54115ac79002fa5a28037","type":"text","conversion_output":true,"text":"We chose not to dichotomize our outcome for many reasons (option \\#3). Dichotomizing women as","text_display":"\n\nWe chose not to dichotomize our outcome for many reasons (option \\#3). Dichotomizing women as","confidence":1,"confidence_rate":1},{"cnt":[[146,2204],[1833,2204],[1833,2249],[146,2249]],"region":{"top_left_x":146,"top_left_y":2204,"width":1687,"height":46},"line":107,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08be702d7f4a44dc8570931e299ea929","type":"text","conversion_output":true,"text":"\"success\" or \"failure\" based on MID could simplify interpretation; however, using purely a responder","text_display":" \"success\" or \"failure\" based on MID could simplify interpretation; however, using purely a responder","confidence":1,"confidence_rate":1},{"cnt":[[146,2247],[1858,2247],[1858,2295],[146,2295]],"region":{"top_left_x":146,"top_left_y":2247,"width":1713,"height":48},"line":108,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b64bb3c0cd69455a9e3da85251ce3be0","type":"text","conversion_output":true,"text":"analysis approach has limitations and some authors recommend avoiding this for primary analyses in","text_display":" analysis approach has limitations and some authors recommend avoiding this for primary analyses in","confidence":1,"confidence_rate":1},{"cnt":[[146,2292],[1936,2292],[1936,2340],[146,2340]],"region":{"top_left_x":146,"top_left_y":2292,"width":1790,"height":48},"line":109,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87620a9daf7a493592e1e23aaac412fe","type":"text","conversion_output":true,"text":"trials. \\({ }^{52}\\) One disadvantage of responder analysis is reduced power and efficiency compared to analysis on","text_display":" trials. \\({ }^{52}\\) One disadvantage of responder analysis is reduced power and efficiency compared to analysis on","confidence":1,"confidence_rate":1},{"cnt":[[146,2338],[1811,2338],[1811,2383],[146,2383]],"region":{"top_left_x":146,"top_left_y":2337,"width":1666,"height":46},"line":110,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f129cd9f7514504a6c84c5cce9064a4","type":"text","conversion_output":true,"text":"the original scale, primarily due to the loss of information associated with lumping groups together.","text_display":" the original scale, primarily due to the loss of information associated with lumping groups together.","confidence":1,"confidence_rate":1},{"cnt":[[146,2380],[1897,2380],[1897,2426],[146,2426]],"region":{"top_left_x":146,"top_left_y":2380,"width":1752,"height":46},"line":111,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c34368ffb3f4d549f12ced94490473f","type":"text","conversion_output":true,"text":"Particularly relevant to ESTEEM, some women could have worse scores compared to baseline and this","text_display":" Particularly relevant to ESTEEM, some women could have worse scores compared to baseline and this","confidence":1,"confidence_rate":1},{"cnt":[[146,2426],[1964,2426],[1964,2471],[146,2471]],"region":{"top_left_x":146,"top_left_y":2425,"width":1818,"height":46},"line":112,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e9446d52b5e45019e046f3dd435494f","type":"text","conversion_output":true,"text":"information would be lost because they would be grouped with those who may have \"slightly\" improved, but","text_display":" information would be lost because they would be grouped with those who may have \"slightly\" improved, 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Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd7fad636b9042448a00e9302f5a0a29","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68c6a811bcec4efea015e3671563d4be","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,254],[146,254]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":40},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d4ec59ae9c74f9897f93bbc25451156","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1953,260],[1953,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1807,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e885de8a28924efa9ac51cebb96e6747","type":"text","conversion_output":true,"text":"just not enough to be classified as a \"success\". Also relevant to ESTEEM, if both groups worsened but one","text_display":"\njust not enough to be classified as a \"success\". Also relevant to ESTEEM, if both groups worsened but one","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1474,305],[1474,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1328,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04a598d5cea5402489569fe07bcbb7ba","type":"text","conversion_output":true,"text":"group \"worsened less\", this information would also be lost using this approach.","text_display":" group \"worsened less\", this information would also be lost using this approach.","confidence":1,"confidence_rate":1},{"cnt":[[271,348],[1871,348],[1871,393],[271,393]],"region":{"top_left_x":270,"top_left_y":348,"width":1602,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"866c1848e0aa43029a34c86927075aa7","type":"text","conversion_output":true,"text":"Because the trial is randomized and we will be stratifying by UUI severity, we would expect the","text_display":"\n\nBecause the trial is randomized and we will be stratifying by UUI severity, we would expect the","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1884,391],[1884,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1739,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"007a4619939d4dd194fb1bea6daf798b","type":"text","conversion_output":true,"text":"baseline UDI scores to be similar between groups. If the average baseline score is the same in the two","text_display":" baseline UDI scores to be similar between groups. If the average baseline score is the same in the two","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[146,436],[1869,436],[1869,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1724,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d73876d95ae40b29105d7071ffd6003","type":"text","conversion_output":true,"text":"groups, then comparing the mean change in UDI score between groups (option \\#2) is mathematically","text_display":" groups, then comparing the mean change in UDI score between groups (option \\#2) is mathematically","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[146,479],[1944,479],[1944,522],[146,522]],"region":{"top_left_x":146,"top_left_y":479,"width":1799,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7334a2d8f3fa411f832df08779b3ec09","type":"text","conversion_output":true,"text":"equivalent to comparing post-operative UDI scores at 1 year between groups (option \\#1). However, option","text_display":" equivalent to comparing post-operative UDI scores at 1 year between groups (option \\#1). However, option","confidence":0.99658203125,"confidence_rate":0.9999691552203086},{"cnt":[[146,524],[1919,524],[1919,569],[146,569]],"region":{"top_left_x":146,"top_left_y":524,"width":1773,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd08010bb88347d4857b6a9cee75b4d5","type":"text","conversion_output":true,"text":"\\#2 has some advantages in that (1) if baseline scores are not the same in the two groups, comparing the","text_display":" \\#2 has some advantages in that (1) if baseline scores are not the same in the two groups, comparing the","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[146,567],[1929,567],[1929,612],[146,612]],"region":{"top_left_x":146,"top_left_y":567,"width":1784,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb85395e825b41d7870b5107b30eddf7","type":"text","conversion_output":true,"text":"mean change in UDI score between groups at 12 months will account for that baseline difference, and (2)","text_display":" mean change in UDI score between groups at 12 months will account for that baseline difference, and (2)","confidence":0.9560546875,"confidence_rate":0.9995952156133602},{"cnt":[[146,610],[1962,610],[1962,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1816,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0b8c3f2ad854f2294d7b22a314dc719","type":"text","conversion_output":true,"text":"UDI scores typically have a distribution that is highly skewed, but differences from baseline should be close","text_display":" UDI scores typically have a distribution that is highly skewed, but differences from baseline should be close","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[1949,655],[1949,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1803,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"689a8266a7df4aab8b227fc9466f37ad","type":"text","conversion_output":true,"text":"enough to being normally distributed that analysis methods that assume a normal distribution can be used.","text_display":" enough to being normally distributed that analysis methods that assume a normal distribution can be used.","confidence":1,"confidence_rate":1},{"cnt":[[146,739],[1128,739],[1128,786],[146,786]],"region":{"top_left_x":146,"top_left_y":739,"width":982,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3185baad70164a5684258ba5151b6093","type":"section_header","conversion_output":false,"children_ids":["4087f3739f7345f2b30f76c39a5a2a58"],"text":"","text_display":""},{"cnt":[[146,743],[1124,743],[1124,784],[146,784]],"region":{"top_left_x":146,"top_left_y":743,"width":978,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4087f3739f7345f2b30f76c39a5a2a58","type":"text","conversion_output":true,"parent_id":"3185baad70164a5684258ba5151b6093","text":"3.4.1.a Rationale for using UDI as primary study outcome","text_display":"\n\n\\subsection*{3.4.1.a Rationale for using UDI as primary study outcome}","confidence":0.89306640625,"confidence_rate":0.9981477120694289},{"cnt":[[271,795],[1962,795],[1962,840],[271,840]],"region":{"top_left_x":270,"top_left_y":794,"width":1692,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12e72eaf8e2b4016bf3323f458343c47","type":"text","conversion_output":true,"text":"Due to limitations in how to best define successful treatment of MUI, the investigators had extensive","text_display":"\n\nDue to limitations in how to best define successful treatment of MUI, the investigators had extensive","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[146,838],[1940,838],[1940,883],[146,883]],"region":{"top_left_x":146,"top_left_y":837,"width":1795,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"606f5db0bb204c12a7425efcc84f6e26","type":"text","conversion_output":true,"text":"discussion around whether an objective, subjective, or composite outcome would be best for this trial. The","text_display":" discussion around whether an objective, subjective, or composite outcome would be best for this trial. The","confidence":1,"confidence_rate":1},{"cnt":[[146,883],[1949,883],[1949,926],[146,926]],"region":{"top_left_x":146,"top_left_y":883,"width":1803,"height":43},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48ba5394b7d24f83b5ffa4dd4be38a27","type":"text","conversion_output":true,"text":"team agreed that the primary outcome must remain true to the clinical question and be clinically relevant in","text_display":" team agreed that the primary outcome must remain true to the clinical question and be clinically relevant in","confidence":1,"confidence_rate":1},{"cnt":[[146,926],[1919,926],[1919,971],[146,971]],"region":{"top_left_x":146,"top_left_y":925,"width":1773,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d200b227a4a428aa6ac110f53c9eb18","type":"text","conversion_output":true,"text":"capturing both potential benefit and harm of both the control and the intervention for this trial. It is critical","text_display":" capturing both potential benefit and harm of both the control and the intervention for this trial. It is critical","confidence":1,"confidence_rate":1},{"cnt":[[146,971],[1940,971],[1940,1016],[146,1016]],"region":{"top_left_x":146,"top_left_y":971,"width":1795,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8e92d7f0a92487e979f516749051ae2","type":"text","conversion_output":true,"text":"that the outcome is meaningful from the patient perspective and will be able to capture OAB improvement,","text_display":" that the outcome is meaningful from the patient perspective and will be able to capture OAB improvement,","confidence":0.85546875,"confidence_rate":0.99856886253549},{"cnt":[[146,1014],[1944,1014],[1944,1059],[146,1059]],"region":{"top_left_x":146,"top_left_y":1014,"width":1799,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b6ed6b82e784402980668a9c9bb6e04","type":"text","conversion_output":true,"text":"worsening, or no change in symptoms. The team discussed using bladder diary, patient global impression,","text_display":" worsening, or no change in symptoms. The team discussed using bladder diary, patient global impression,","confidence":1,"confidence_rate":1},{"cnt":[[146,1057],[1620,1057],[1620,1102],[146,1102]],"region":{"top_left_x":146,"top_left_y":1057,"width":1474,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ee3924c9c5241bda9d37f7dc043207a","type":"text","conversion_output":true,"text":"or OAB PROs. Arguments against each of these were based on the following rationale:","text_display":" or OAB PROs. Arguments against each of these were based on the following rationale:","confidence":0.998046875,"confidence_rate":0.9999777839418279},{"cnt":[[275,1147],[1248,1147],[1248,1192],[275,1192]],"region":{"top_left_x":275,"top_left_y":1147,"width":974,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0eb9e821c3542d4baa61070e39e1460","type":"text","conversion_output":true,"text":"1. Problems with using bladder diary as primary outcome:","text_display":"\n1. Problems with using bladder diary as primary outcome:","confidence":1,"confidence_rate":1},{"cnt":[[271,1190],[1962,1190],[1962,1235],[271,1235]],"region":{"top_left_x":270,"top_left_y":1190,"width":1692,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14471c11810e4ff69b1f4a33dd3348d0","type":"text","conversion_output":true,"text":"a. Diary does not capture a meaningful patient outcome- It is becoming clear that typical clinical trial","text_display":"\na. Diary does not capture a meaningful patient outcome- It is becoming clear that typical clinical trial","confidence":1,"confidence_rate":1},{"cnt":[[146,1233],[1869,1233],[1869,1278],[146,1278]],"region":{"top_left_x":146,"top_left_y":1233,"width":1724,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c38d5661b0084de5a2c4d8d915acdae7","type":"text","conversion_output":true,"text":"endpoints such as reduction in IEs, voided volumes, etc do not capture what is meaningful to patients.","text_display":" endpoints such as reduction in IEs, voided volumes, etc do not capture what is meaningful to patients.","confidence":1,"confidence_rate":1},{"cnt":[[146,1276],[1964,1276],[1964,1321],[146,1321]],"region":{"top_left_x":146,"top_left_y":1276,"width":1818,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b373e3a8ff9440288b257dc345036bb","type":"text","conversion_output":true,"text":"Counting IEs on diary likely does not capture what is important to a patient (e.g. having 3 large urge leaks a","text_display":" Counting IEs on diary likely does not capture what is important to a patient (e.g. having 3 large urge leaks a","confidence":1,"confidence_rate":1},{"cnt":[[146,1366],[146,1319],[1979,1321],[1979,1369]],"region":{"top_left_x":146,"top_left_y":1319,"width":1833,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"050c89760ad14c6db90373f88dfbadb4","type":"text","conversion_output":true,"text":"day may be more bothersome than having 20 small stress leaks or having 20 urgency associated voids may","text_display":" day may be more bothersome than having 20 small stress leaks or having 20 urgency associated voids may","confidence":1,"confidence_rate":1},{"cnt":[[146,1366],[1854,1366],[1854,1412],[146,1412]],"region":{"top_left_x":146,"top_left_y":1366,"width":1709,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d42665f563bd41189d84c89ca7357890","type":"text","conversion_output":true,"text":"be more bothersome than having 1 UUI episode). In addition, diary IEs do not correlate perfectly with","text_display":" be more bothersome than having 1 UUI episode). In addition, diary IEs do not correlate perfectly with","confidence":1,"confidence_rate":1},{"cnt":[[146,1405],[1858,1405],[1858,1454],[146,1454]],"region":{"top_left_x":146,"top_left_y":1405,"width":1713,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e65700e56d04a419212bdce84d0dcb2","type":"text","conversion_output":true,"text":"patient satisfaction. \\({ }^{53}\\) Finally, bladder diaries have been shown to be less reliable in women with MUI,","text_display":" patient satisfaction. \\({ }^{53}\\) Finally, bladder diaries have been shown to be less reliable in women with MUI,","confidence":1,"confidence_rate":1},{"cnt":[[146,1452],[767,1452],[767,1497],[146,1497]],"region":{"top_left_x":146,"top_left_y":1452,"width":621,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"640a2334c2604bbb8189dcb816a93b10","type":"text","conversion_output":true,"text":"particularly for the SUI component. \\({ }^{54}\\)","text_display":" particularly for the SUI component. \\({ }^{54}\\)","confidence":1,"confidence_rate":1},{"cnt":[[271,1497],[1949,1497],[1949,1540],[271,1540]],"region":{"top_left_x":270,"top_left_y":1497,"width":1679,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33af531ade72494fb9629fc6a1444464","type":"text","conversion_output":true,"text":"b. Diary cutoffs to define improvement for MUI are unknown-What percent improvement for the SUI","text_display":"\nb. Diary cutoffs to define improvement for MUI are unknown-What percent improvement for the SUI","confidence":1,"confidence_rate":1},{"cnt":[[146,1543],[1906,1543],[1906,1588],[146,1588]],"region":{"top_left_x":146,"top_left_y":1542,"width":1760,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fa1be4ef4054ea9ba29d2aeabe10678","type":"text","conversion_output":true,"text":"component and for the UUI component is clinically important for a woman with MUI? Any cutoffs chosen","text_display":" component and for the UUI component is clinically important for a woman with MUI? Any cutoffs chosen","confidence":1,"confidence_rate":1},{"cnt":[[146,1586],[466,1586],[466,1631],[146,1631]],"region":{"top_left_x":146,"top_left_y":1585,"width":321,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d860d3f8d364ec2875acbd32da9083e","type":"text","conversion_output":true,"text":"would be arbitrary.","text_display":" would be arbitrary.","confidence":1,"confidence_rate":1},{"cnt":[[271,1629],[1828,1629],[1828,1674],[271,1674]],"region":{"top_left_x":270,"top_left_y":1628,"width":1559,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87f26a0c3ea74c4fba04e5591f82cb63","type":"text","conversion_output":true,"text":"c. Using IEs on bladder diary as a primary outcome would require a minimum number of IEs","text_display":"\nc. Using IEs on bladder diary as a primary outcome would require a minimum number of IEs","confidence":1,"confidence_rate":1},{"cnt":[[146,1674],[1927,1674],[1927,1719],[146,1719]],"region":{"top_left_x":146,"top_left_y":1673,"width":1782,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd3e6a4f2fca4615afaab33ad901d419","type":"text","conversion_output":true,"text":"(approximately \\(3-4\\) IE/3days) at baseline to be able to detect a change. The protocol team felt that setting","text_display":" (approximately \\(3-4\\) IE/3days) at baseline to be able to detect a change. The protocol team felt that setting","confidence":0.6729710102081299,"confidence_rate":0.9965619842028366},{"cnt":[[146,1714],[1936,1714],[1936,1762],[146,1762]],"region":{"top_left_x":146,"top_left_y":1714,"width":1790,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac89198377e949acb2dac047311b56fe","type":"text","conversion_output":true,"text":"such strict inclusion criteria would be too limiting to allow recruitment of a good range of MUI severity (see","text_display":" such strict inclusion criteria would be too limiting to allow recruitment of a good range of MUI severity (see","confidence":1,"confidence_rate":1},{"cnt":[[146,1762],[672,1762],[672,1807],[146,1807]],"region":{"top_left_x":146,"top_left_y":1761,"width":527,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a085f4c6f4834e5abc3268ff611f99dc","type":"text","conversion_output":true,"text":"Inclusion Criteria, Section 4.2).","text_display":" Inclusion Criteria, Section 4.2).","confidence":1,"confidence_rate":1},{"cnt":[[271,1805],[1934,1805],[1934,1850],[271,1850]],"region":{"top_left_x":270,"top_left_y":1804,"width":1664,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d915ec18a7894958a5ccaf635b3a7009","type":"text","conversion_output":true,"text":"For all of these reasons, the team decided against using bladder diary IEs as the primary outcome","text_display":"\n\nFor all of these reasons, the team decided against using bladder diary IEs as the primary outcome","confidence":1,"confidence_rate":1},{"cnt":[[146,1848],[1678,1848],[1678,1893],[146,1893]],"region":{"top_left_x":146,"top_left_y":1847,"width":1532,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dcfeb33fad7643b98f61f3f5b32a6caf","type":"text","conversion_output":true,"text":"and to instead focus on measures that can capture outcomes from the patient perspective.","text_display":" and to instead focus on measures that can capture outcomes from the patient perspective.","confidence":1,"confidence_rate":1},{"cnt":[[271,1934],[1480,1934],[1480,1983],[271,1983]],"region":{"top_left_x":270,"top_left_y":1933,"width":1211,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09467cb85f724a959703018ab6a8d423","type":"section_header","conversion_output":false,"children_ids":["7d35b7425c994103970d114d51084c16"],"text":"","text_display":""},{"cnt":[[275,1938],[1476,1938],[1476,1979],[275,1979]],"region":{"top_left_x":275,"top_left_y":1937,"width":1201,"height":42},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d35b7425c994103970d114d51084c16","type":"text","conversion_output":true,"parent_id":"09467cb85f724a959703018ab6a8d423","text":"2. Problems with using global impression measure as primary outcome","text_display":"\n\n\\section*{2. Problems with using global impression measure as primary outcome}","confidence":1,"confidence_rate":1},{"cnt":[[271,1981],[1846,1981],[1846,2026],[271,2026]],"region":{"top_left_x":270,"top_left_y":1980,"width":1576,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad23c5760e5045a9b12214e3c9313e22","type":"text","conversion_output":true,"text":"A patient's overall/global impression of improvement would be reflective of her overall urinary","text_display":"\n\nA patient's overall/global impression of improvement would be reflective of her overall urinary","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[146,2024],[1955,2024],[1955,2069],[146,2069]],"region":{"top_left_x":146,"top_left_y":2023,"width":1810,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26caa61cc3f444729f61f946958188f3","type":"text","conversion_output":true,"text":"condition. Although this outcome would seemingly be ideal for capturing a meaningful outcome, for our trial","text_display":" condition. Although this outcome would seemingly be ideal for capturing a meaningful outcome, for our trial","confidence":1,"confidence_rate":1},{"cnt":[[146,2067],[1966,2067],[1966,2112],[146,2112]],"region":{"top_left_x":146,"top_left_y":2066,"width":1820,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"406883336f1e45149563b1e9f4df1f2c","type":"text","conversion_output":true,"text":"it could potentially introduce bias. Because it is not feasible to mask subjects in ESTEEM to the intervention","text_display":" it could potentially introduce bias. Because it is not feasible to mask subjects in ESTEEM to the intervention","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[148,2110],[1953,2110],[1953,2157],[148,2157]],"region":{"top_left_x":148,"top_left_y":2109,"width":1805,"height":49},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc47a4342494410a965463218a29c283","type":"text","conversion_output":true,"text":"(BPTx), a single, subjective global impression item would be subject to bias. For example, if subjects in the","text_display":" (BPTx), a single, subjective global impression item would be subject to bias. For example, if subjects in the","confidence":1,"confidence_rate":1},{"cnt":[[146,2157],[1949,2157],[1949,2202],[146,2202]],"region":{"top_left_x":146,"top_left_y":2157,"width":1803,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bc8b2cb82f54bc1a815b043d815c641","type":"text","conversion_output":true,"text":"control group were more likely to ask for additional treatment and report they were not \"improved\" because","text_display":" control group were more likely to ask for additional treatment and report they were not \"improved\" because","confidence":1,"confidence_rate":1},{"cnt":[[146,2200],[1884,2200],[1884,2245],[146,2245]],"region":{"top_left_x":146,"top_left_y":2200,"width":1739,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba5828e98e9e484191ba08d3fbfb1b36","type":"text","conversion_output":true,"text":"they knew there was another potential treatment available that they did not receive, this would bias our","text_display":" they knew there was another potential treatment available that they did not receive, this would bias our","confidence":1,"confidence_rate":1},{"cnt":[[146,2243],[1957,2243],[1957,2288],[146,2288]],"region":{"top_left_x":146,"top_left_y":2242,"width":1812,"height":47},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b3d740d1f3b4c829f14caaf5495c7b4","type":"text","conversion_output":true,"text":"study towards a higher failure rate in the control group (making our intervention seem more effective than it","text_display":" study towards a higher failure rate in the control group (making our intervention seem more effective than it","confidence":1,"confidence_rate":1},{"cnt":[[146,2288],[1979,2288],[1979,2331],[146,2331]],"region":{"top_left_x":146,"top_left_y":2288,"width":1833,"height":44},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1928697221954b43baac98bdb24a0838","type":"text","conversion_output":true,"text":"really is). The challenges of masking or designing a sham procedure for the control group for ESTEEM have","text_display":" really is). The challenges of masking or designing a sham procedure for the control group for ESTEEM have","confidence":1,"confidence_rate":1},{"cnt":[[146,2329],[831,2329],[831,2374],[146,2374]],"region":{"top_left_x":146,"top_left_y":2328,"width":686,"height":47},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0c5ae6f627b43928586cd678a30d0a1","type":"text","conversion_output":true,"text":"already been noted above (Section 3.2).","text_display":" already been noted above (Section 3.2).","confidence":1,"confidence_rate":1},{"cnt":[[271,2415],[1354,2415],[1354,2466],[271,2466]],"region":{"top_left_x":270,"top_left_y":2414,"width":1084,"height":53},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b03e0c21268042909692fa37bcc09261","type":"section_header","conversion_output":false,"children_ids":["380d8486fceb4b8789634d426d727b3d"],"text":"","text_display":""},{"cnt":[[275,2419],[1351,2419],[1351,2464],[275,2464]],"region":{"top_left_x":275,"top_left_y":2419,"width":1077,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"380d8486fceb4b8789634d426d727b3d","type":"text","conversion_output":true,"parent_id":"b03e0c21268042909692fa37bcc09261","text":"3. Problems with using OAB PRO measure as primary outcome","text_display":"\n\n\\section*{3. Problems with using OAB PRO measure as primary outcome}","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfa1698ffbe546b68b86e9f7b8b1240a","type":"page_info","conversion_output":false,"text":"18","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1b7f47f3186408791bdafda8dca7cb0","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-19","page":19,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a505fa845134aa0a9be433e72ae9a3c","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6996d13ad0840379306883600c45cf9","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a80097507e894433838d3c86d3c0d08a","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,254],[146,254]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":40},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bb827706d8641d7a3df34b08f90e65b","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[271,260],[1962,260],[1962,303],[271,303]],"region":{"top_left_x":270,"top_left_y":259,"width":1692,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9cb5ca760f845af8fec75c61571cb48","type":"text","conversion_output":true,"text":"Finally, we considered using an OAB PRO as the primary outcome, such as the Overactive Bladder","text_display":"\n\nFinally, we considered using an OAB PRO as the primary outcome, such as the Overactive Bladder","confidence":0.96826171875,"confidence_rate":0.9996742666218359},{"cnt":[[146,301],[1944,301],[1944,348],[146,348]],"region":{"top_left_x":146,"top_left_y":300,"width":1799,"height":49},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea66ff1621f94cf4a9128b9c1547d5a8","type":"text","conversion_output":true,"text":"Questionnaire (OAB-q) \\({ }^{55}\\) or the UDI-irritative subscale. However, these do not account for SUI symptoms,","text_display":" Questionnaire (OAB-q) \\({ }^{55}\\) or the UDI-irritative subscale. However, these do not account for SUI symptoms,","confidence":0.99560546875,"confidence_rate":0.99996299046987},{"cnt":[[144,348],[1962,348],[1962,393],[144,393]],"region":{"top_left_x":143,"top_left_y":348,"width":1819,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49bde45217af4dd99c6a9b7c2b41273e","type":"text","conversion_output":true,"text":"which are part of the MUI symptom constellation. In addition, it is still unclear whether patients with MUI are","text_display":" which are part of the MUI symptom constellation. In addition, it is still unclear whether patients with MUI are","confidence":1,"confidence_rate":1},{"cnt":[[146,389],[1882,389],[1882,436],[146,436]],"region":{"top_left_x":146,"top_left_y":388,"width":1737,"height":49},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa6fe7c3b1914ba89aaf7a71fa2a891d","type":"text","conversion_output":true,"text":"at risk of sling failure for SUI and at least 2 studies suggest this may be the case. \\({ }^{27,28}\\) Finally, there are","text_display":" at risk of sling failure for SUI and at least 2 studies suggest this may be the case. \\({ }^{27,28}\\) Finally, there are","confidence":0.9721813201904297,"confidence_rate":0.9997796106290486},{"cnt":[[146,434],[1966,434],[1966,481],[146,481]],"region":{"top_left_x":146,"top_left_y":433,"width":1820,"height":49},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c045f16481f94f27a01e7f41663f6023","type":"text","conversion_output":true,"text":"some women with MUI who may not be able to clearly distinguish all UI episodes as stress- or urge- related","text_display":" some women with MUI who may not be able to clearly distinguish all UI episodes as stress- or urge- related","confidence":1,"confidence_rate":1},{"cnt":[[146,477],[1927,477],[1927,526],[146,526]],"region":{"top_left_x":146,"top_left_y":476,"width":1782,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"714e8ae2bb30448f927782c3c5b375d2","type":"text","conversion_output":true,"text":"and the team felt it would be important to also capture these symptoms. Finally, specifically regarding the","text_display":" and the team felt it would be important to also capture these symptoms. Finally, specifically regarding the","confidence":1,"confidence_rate":1},{"cnt":[[146,522],[1416,522],[1416,569],[146,569]],"region":{"top_left_x":146,"top_left_y":522,"width":1270,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"782e2cbe242345c3a15521cab9e26ee0","type":"text","conversion_output":true,"text":"OAB-q, there is less validity data in a MUI population compared to the UDI.","text_display":" OAB-q, there is less validity data in a MUI population compared to the UDI.","confidence":0.9980475902557373,"confidence_rate":0.9999755713211275},{"cnt":[[271,610],[1800,610],[1800,655],[271,655]],"region":{"top_left_x":270,"top_left_y":610,"width":1531,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91ff439f889843668cb3fa780ba2584d","type":"text","conversion_output":true,"text":"For all of these reasons, using the UDI as the primary outcome is ideal and it has all of the","text_display":"\n\nFor all of these reasons, using the UDI as the primary outcome is ideal and it has all of the","confidence":1,"confidence_rate":1},{"cnt":[[146,653],[1072,653],[1072,698],[146,698]],"region":{"top_left_x":146,"top_left_y":653,"width":927,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d864c3037a5e491eb69bdc95bb67697f","type":"text","conversion_output":true,"text":"characteristics that are important for a MUI population:","text_display":" characteristics that are important for a MUI population:","confidence":1,"confidence_rate":1},{"cnt":[[271,696],[1704,696],[1704,743],[271,743]],"region":{"top_left_x":270,"top_left_y":696,"width":1434,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f19a53f6fca4627a04552476af056a0","type":"text","conversion_output":true,"text":"1. The overall UDI score includes both a stress and irritative subscale, allowing us to","text_display":"\n1. The overall UDI score includes both a stress and irritative subscale, allowing us to","confidence":1,"confidence_rate":1},{"cnt":[[271,743],[1379,743],[1379,788],[271,788]],"region":{"top_left_x":270,"top_left_y":743,"width":1110,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86150fb597d54e888934cc67d5648328","type":"text","conversion_output":true,"text":"comprehensively capture both SUI and OAB symptom outcomes.","text_display":" comprehensively capture both SUI and OAB symptom outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[271,786],[1927,786],[1927,831],[271,831]],"region":{"top_left_x":270,"top_left_y":786,"width":1658,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afe61e92ec8d41cf8d821b8c49b91112","type":"text","conversion_output":true,"text":"2. It captures a meaningful outcome from the patient perspective, incorporating both the presence","text_display":"\n2. It captures a meaningful outcome from the patient perspective, incorporating both the presence","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[271,829],[939,829],[939,879],[271,879]],"region":{"top_left_x":270,"top_left_y":829,"width":669,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cf13ff55cfd4c42bfccb052248834d2","type":"text","conversion_output":true,"text":"and bother of SUI and OAB symptoms.","text_display":" and bother of SUI and OAB symptoms.","confidence":0.9990234375,"confidence_rate":0.9999755743071164},{"cnt":[[271,872],[1957,872],[1957,922],[271,922]],"region":{"top_left_x":270,"top_left_y":872,"width":1688,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7abfa2d1e1f0462a820d39bd37132ad6","type":"text","conversion_output":true,"text":"3. It includes 3 UI items that are not necessarily specific to stress or urge and thus can help capture","text_display":"\n3. It includes 3 UI items that are not necessarily specific to stress or urge and thus can help capture","confidence":1,"confidence_rate":1},{"cnt":[[271,917],[1480,917],[1480,965],[271,965]],"region":{"top_left_x":270,"top_left_y":917,"width":1211,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6b315e7545648bd8f65337222600944","type":"text","conversion_output":true,"text":"UI episodes for which patients cannot clearly distinguish as SUI or UUI.","text_display":" UI episodes for which patients cannot clearly distinguish as SUI or UUI.","confidence":0.99951171875,"confidence_rate":0.9999936571565041},{"cnt":[[271,962],[1772,962],[1772,1008],[271,1008]],"region":{"top_left_x":270,"top_left_y":962,"width":1503,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a505e10280442169fe29c85a03cb1ab","type":"text","conversion_output":true,"text":"4. It can capture both improvement and worsening of preexisting symptoms, but also the","text_display":"\n4. It can capture both improvement and worsening of preexisting symptoms, but also the","confidence":0.998046875,"confidence_rate":0.9999785163314827},{"cnt":[[271,1003],[973,1003],[973,1051],[271,1051]],"region":{"top_left_x":270,"top_left_y":1003,"width":704,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"237dca028ccd4ab1aefa5a1aff9f2786","type":"text","conversion_output":true,"text":"development of new urinary symptoms. \\({ }^{56}\\)","text_display":" development of new urinary symptoms. \\({ }^{56}\\)","confidence":0.99853515625,"confidence_rate":0.9999706820761288},{"cnt":[[271,1094],[1964,1094],[1964,1141],[271,1141]],"region":{"top_left_x":270,"top_left_y":1093,"width":1694,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d470908d25c49a886389e3f9c11286c","type":"text","conversion_output":true,"text":"Because MUI includes both SUI and UUI, it is important to be able to report SUI and OAB outcomes","text_display":"\n\nBecause MUI includes both SUI and UUI, it is important to be able to report SUI and OAB outcomes","confidence":1,"confidence_rate":1},{"cnt":[[146,1139],[1951,1139],[1951,1184],[146,1184]],"region":{"top_left_x":146,"top_left_y":1138,"width":1805,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"420deff342784a49b58f5d269e60cb22","type":"text","conversion_output":true,"text":"separately. There is no clinical rationale for assuming that one component, or that one subscale of the UDI","text_display":" separately. There is no clinical rationale for assuming that one component, or that one subscale of the UDI","confidence":1,"confidence_rate":1},{"cnt":[[146,1182],[1923,1182],[1923,1227],[146,1227]],"region":{"top_left_x":146,"top_left_y":1181,"width":1777,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bcb1f6abb384dd2ac3f68478871a527","type":"text","conversion_output":true,"text":"is more important to women than another. Therefore, the UDI-stress subscale and UDI-irritative subscale","text_display":" is more important to women than another. Therefore, the UDI-stress subscale and UDI-irritative subscale","confidence":1,"confidence_rate":1},{"cnt":[[144,1225],[1921,1225],[1921,1272],[144,1272]],"region":{"top_left_x":143,"top_left_y":1224,"width":1778,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4076c36d3165444f926018e7e6b73126","type":"text","conversion_output":true,"text":"will be important secondary outcomes for which ESTEEM will be powered to detect differences and each","text_display":" will be important secondary outcomes for which ESTEEM will be powered to detect differences and each","confidence":1,"confidence_rate":1},{"cnt":[[144,1268],[1405,1268],[1405,1317],[144,1317]],"region":{"top_left_x":143,"top_left_y":1267,"width":1263,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf775e593c674282a3aeda1534898be0","type":"text","conversion_output":true,"text":"will have a priori analysis plans (see Section 6, Statistical Considerations).","text_display":" will have a priori analysis plans (see Section 6, Statistical Considerations).","confidence":1,"confidence_rate":1},{"cnt":[[142,1349],[973,1349],[973,1403],[142,1403]],"region":{"top_left_x":141,"top_left_y":1349,"width":833,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4fc988afa8e4d7ebe2d66651dc6800c","type":"section_header","conversion_output":false,"children_ids":["8306e201cfb5459caae6a53e2a7d05bc"],"text":"","text_display":""},{"cnt":[[146,1354],[969,1354],[969,1403],[146,1403]],"region":{"top_left_x":146,"top_left_y":1353,"width":823,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8306e201cfb5459caae6a53e2a7d05bc","type":"text","conversion_output":true,"parent_id":"f4fc988afa8e4d7ebe2d66651dc6800c","text":"3.4.1.b. Rationale for timing of primary outcome:","text_display":"\n\n\\subsection*{3.4.1.b. Rationale for timing of primary outcome:}","confidence":1,"confidence_rate":1},{"cnt":[[271,1409],[1931,1409],[1931,1454],[271,1454]],"region":{"top_left_x":270,"top_left_y":1409,"width":1662,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64fedc69aec54caa8d047e5f6a2ec133","type":"text","conversion_output":true,"text":"There was significant discussion regarding the best timing for the primary outcome. In framing this","text_display":"\n\nThere was significant discussion regarding the best timing for the primary outcome. In framing this","confidence":1,"confidence_rate":1},{"cnt":[[146,1452],[1944,1452],[1944,1500],[146,1500]],"region":{"top_left_x":146,"top_left_y":1452,"width":1799,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15a6be3656ad41078535574ddd81547b","type":"text","conversion_output":true,"text":"question, the group considered at which time-point would a difference in outcome lead to recommendation","text_display":" question, the group considered at which time-point would a difference in outcome lead to recommendation","confidence":1,"confidence_rate":1},{"cnt":[[146,1495],[1927,1495],[1927,1543],[146,1543]],"region":{"top_left_x":146,"top_left_y":1495,"width":1782,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06bdda163b964fadbf2bb21d0fd7b88c","type":"text","conversion_output":true,"text":"of BPTx as part of clinical practice. Long-term outcomes of 1 year and/or more are \"standard\" for surgical","text_display":" of BPTx as part of clinical practice. Long-term outcomes of 1 year and/or more are \"standard\" for surgical","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[146,1540],[1893,1540],[1893,1588],[146,1588]],"region":{"top_left_x":146,"top_left_y":1540,"width":1747,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7b0e4ce1f634f8f9e28a2ba2eb63077","type":"text","conversion_output":true,"text":"trials and are important to determine if a surgical treatment is worthwhile. However, outcomes for BPTx","text_display":" trials and are important to determine if a surgical treatment is worthwhile. However, outcomes for BPTx","confidence":1,"confidence_rate":1},{"cnt":[[144,1586],[1850,1586],[1850,1631],[144,1631]],"region":{"top_left_x":143,"top_left_y":1585,"width":1707,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83eddc641fac432fb7dbaae27b6727a6","type":"text","conversion_output":true,"text":"trials are often shorter, between \\(3-6\\) months and there was concern that longer time points may miss","text_display":" trials are often shorter, between \\(3-6\\) months and there was concern that longer time points may miss","confidence":0.98095703125,"confidence_rate":0.9998203280929825},{"cnt":[[146,1629],[1876,1629],[1876,1676],[146,1676]],"region":{"top_left_x":146,"top_left_y":1628,"width":1730,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69acc241fa324a12863a10b5d29c405e","type":"text","conversion_output":true,"text":"improvements which may not be sustained over time. Clinically, women with MUI who ultimately have","text_display":" improvements which may not be sustained over time. Clinically, women with MUI who ultimately have","confidence":1,"confidence_rate":1},{"cnt":[[146,1671],[1966,1671],[1966,1721],[146,1721]],"region":{"top_left_x":146,"top_left_y":1671,"width":1820,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"055f717881714fd9a9f43168b89c04d4","type":"text","conversion_output":true,"text":"persistent OAB symptoms seem to experience a re-occurrence of these symptoms within 3-6 months of the","text_display":" persistent OAB symptoms seem to experience a re-occurrence of these symptoms within 3-6 months of the","confidence":0.6348276624921709,"confidence_rate":0.9959510609811301},{"cnt":[[146,1714],[1936,1714],[1936,1764],[146,1764]],"region":{"top_left_x":146,"top_left_y":1714,"width":1790,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5845ee4eb3844cf4a37265041019f4e7","type":"text","conversion_output":true,"text":"index MUS surgery and therefore, many investigators felt it was important for the outcome to be at least 6","text_display":" index MUS surgery and therefore, many investigators felt it was important for the outcome to be at least 6","confidence":1,"confidence_rate":1},{"cnt":[[146,1762],[466,1762],[466,1807],[146,1807]],"region":{"top_left_x":146,"top_left_y":1761,"width":321,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80ff84051ae949e6a293498154ea647b","type":"text","conversion_output":true,"text":"months or greater.","text_display":" months or greater.","confidence":1,"confidence_rate":1},{"cnt":[[271,1805],[1949,1805],[1949,1850],[271,1850]],"region":{"top_left_x":270,"top_left_y":1804,"width":1679,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe286e5b57d9453a9ddad6191be264e0","type":"text","conversion_output":true,"text":"Based on these considerations, the primary outcome will be the change in UDI score from baseline","text_display":"\n\nBased on these considerations, the primary outcome will be the change in UDI score from baseline","confidence":1,"confidence_rate":1},{"cnt":[[146,1848],[1957,1848],[1957,1895],[146,1895]],"region":{"top_left_x":146,"top_left_y":1847,"width":1812,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69239090f65f47a98343f5a8c550cfb1","type":"text","conversion_output":true,"text":"and 12 months postoperative, given the intervention is the combination of BPTx and surgery, with Time \\(0=\\)","text_display":" and 12 months postoperative, given the intervention is the combination of BPTx and surgery, with Time \\(0=\\)","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[146,1891],[1972,1891],[1972,1938],[146,1938]],"region":{"top_left_x":146,"top_left_y":1890,"width":1827,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ac2279f446a4b5cb0f142903e74db17","type":"text","conversion_output":true,"text":"the time of surgery. Note that if a participant is randomized but surgery is not performed, then Time 0 will be","text_display":" the time of surgery. Note that if a participant is randomized but surgery is not performed, then Time 0 will be","confidence":0.99951171875,"confidence_rate":0.9999958958025558},{"cnt":[[146,1934],[1893,1934],[1893,1983],[146,1983]],"region":{"top_left_x":146,"top_left_y":1933,"width":1747,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8803a75003734e0999b245f4d86a1bad","type":"text","conversion_output":true,"text":"the planned surgery date. A secondary outcome will include time to failure; therefore, we will be able to","text_display":" the planned surgery date. A secondary outcome will include time to failure; therefore, we will be able to","confidence":1,"confidence_rate":1},{"cnt":[[146,1979],[1833,1979],[1833,2026],[146,2026]],"region":{"top_left_x":146,"top_left_y":1978,"width":1687,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f0c53488260425980635d6f0af62579","type":"text","conversion_output":true,"text":"detect any potential early differences that are not sustained at 12 months (See Section 6, Statistical","text_display":" detect any potential early differences that are not sustained at 12 months (See Section 6, Statistical","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[144,2024],[1878,2024],[1878,2071],[144,2071]],"region":{"top_left_x":143,"top_left_y":2023,"width":1735,"height":49},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b27a06c8d27466f81d034224878fea9","type":"text","conversion_output":true,"text":"Analysis). Additional assessments will be made at 3 and 6 months postoperatively, which will allow for","text_display":" Analysis). Additional assessments will be made at 3 and 6 months postoperatively, which will allow for","confidence":1,"confidence_rate":1},{"cnt":[[146,2067],[874,2067],[874,2110],[146,2110]],"region":{"top_left_x":146,"top_left_y":2066,"width":729,"height":44},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f76082a5165b44a2ab47e8be646cd1b0","type":"text","conversion_output":true,"text":"shorter-term assessments of BPTx effects.","text_display":" shorter-term assessments of BPTx effects.","confidence":1,"confidence_rate":1},{"cnt":[[142,2191],[1807,2191],[1807,2245],[142,2245]],"region":{"top_left_x":141,"top_left_y":2191,"width":1666,"height":55},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb99dcf15a5a403a99cfbac007ee4a22","type":"section_header","conversion_output":false,"children_ids":["d22413b3ef5843b0a49b892aca244db7"],"text":"","text_display":""},{"cnt":[[146,2196],[1803,2196],[1803,2241],[146,2241]],"region":{"top_left_x":146,"top_left_y":2195,"width":1657,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d22413b3ef5843b0a49b892aca244db7","type":"text","conversion_output":true,"parent_id":"cb99dcf15a5a403a99cfbac007ee4a22","text":"3.4.1.c. Management of subjects who request additional treatment for SUI and/or OAB after MUS:","text_display":"\n\n\\subsection*{3.4.1.c. Management of subjects who request additional treatment for SUI and/or OAB after MUS:}","confidence":1,"confidence_rate":1},{"cnt":[[271,2252],[1955,2252],[1955,2297],[271,2297]],"region":{"top_left_x":270,"top_left_y":2251,"width":1686,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d798b5e1b5e4828a06c6d6f58175b1c","type":"text","conversion_output":true,"text":"The overarching goal of ESTEEM is to evaluate the effect of combined treatment on improving both","text_display":"\n\nThe overarching goal of ESTEEM is to evaluate the effect of combined treatment on improving both","confidence":1,"confidence_rate":1},{"cnt":[[146,2295],[1919,2295],[1919,2342],[146,2342]],"region":{"top_left_x":146,"top_left_y":2294,"width":1773,"height":48},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c3ead6ddce44c0d99e33c01265bfbe7","type":"text","conversion_output":true,"text":"SUI and UUI outcomes in women with MUI. Therefore, any request for additional treatment for any lower","text_display":" SUI and UUI outcomes in women with MUI. Therefore, any request for additional treatment for any lower","confidence":1,"confidence_rate":1},{"cnt":[[146,2340],[1931,2340],[1931,2387],[146,2387]],"region":{"top_left_x":146,"top_left_y":2339,"width":1786,"height":48},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5aa9f00b3b0645ffbb6b6eb2593ca9df","type":"text","conversion_output":true,"text":"urinary tract symptoms (SUI, UUI/OAB, voiding dysfunction) before the 1 year outcome for either of these","text_display":" urinary tract symptoms (SUI, UUI/OAB, voiding dysfunction) before the 1 year outcome for either of these","confidence":1,"confidence_rate":1},{"cnt":[[146,2385],[1944,2385],[1944,2430],[146,2430]],"region":{"top_left_x":146,"top_left_y":2384,"width":1799,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29dda647441a431ea48bb8c565233b59","type":"text","conversion_output":true,"text":"symptoms will be considered treatment failure. The team agreed it would be difficult to withhold additional","text_display":" symptoms will be considered treatment failure. The team agreed it would be difficult to withhold additional","confidence":1,"confidence_rate":1},{"cnt":[[146,2428],[1876,2428],[1876,2473],[146,2473]],"region":{"top_left_x":146,"top_left_y":2427,"width":1730,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f85f21d4eab8458da33081bf4e76fcca","type":"text","conversion_output":true,"text":"treatment from either group for the 1 year study duration; however, any additional treatment should be","text_display":" treatment from either group for the 1 year study duration; however, any additional treatment should be","confidence":0.99658203125,"confidence_rate":0.9999688748175845},{"cnt":[[146,2471],[1944,2471],[1944,2516],[146,2516]],"region":{"top_left_x":146,"top_left_y":2470,"width":1799,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41a1a79adb5f48599e673a6638191e09","type":"text","conversion_output":true,"text":"initiated after the acute postoperative recovery period. Clinically, some women may experience immediate","text_display":" initiated after the acute postoperative recovery period. Clinically, some women may experience immediate","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1937b9092f847c0902cda814aadc45d","type":"page_info","conversion_output":false,"text":"19","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fdae87cb3f1485da3a5f2626f256045","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-20","page":20,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca17f209933949c5ac897ed21afe2950","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b9744a522754bc7804b7656be06bc64","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4a3808c51d8420d8b0eecf3037bf1ac","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6ff9ca0ee774304b8814bde81ecd22f","type":"text","conversion_output":true,"text":"Confidential","text_display":"\n\nConfidential","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1785,260],[1785,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1640,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1dc8927d9464490a23cdf2907158ab4","type":"text","conversion_output":true,"text":"exacerbation of OAB symptoms after MUS followed by improvement, whereas other women may","text_display":"\nexacerbation of OAB symptoms after MUS followed by improvement, whereas other women may","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1944,305],[1944,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1799,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ea53731d5364e4db3636022f52d3288","type":"text","conversion_output":true,"text":"experience initial improvement but then recurrence of OAB symptoms several months later. Therefore, the","text_display":" experience initial improvement but then recurrence of OAB symptoms several months later. Therefore, the","confidence":0.91796875,"confidence_rate":0.999207796085869},{"cnt":[[146,348],[1949,348],[1949,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1803,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d74e467005234c86b0c42d31ecd27208","type":"text","conversion_output":true,"text":"team came to a consensus that any additional treatment should be deferred until 3 months postoperatively","text_display":" team came to a consensus that any additional treatment should be deferred until 3 months postoperatively","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1850,391],[1850,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1704,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6ac86508e8244a19dca0cd946e5596f","type":"text","conversion_output":true,"text":"when OAB symptoms would be expected to have reached a baseline. This will allow enough time for","text_display":" when OAB symptoms would be expected to have reached a baseline. This will allow enough time for","confidence":0.5216724872589111,"confidence_rate":0.9938799804284779},{"cnt":[[146,436],[1910,436],[1910,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1764,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df516d49c17b4d25b36d68d533ee4ff9","type":"text","conversion_output":true,"text":"complete physical and tissue recovery from the surgical procedure, will allow for assessment of potential","text_display":" complete physical and tissue recovery from the surgical procedure, will allow for assessment of potential","confidence":1,"confidence_rate":1},{"cnt":[[146,481],[1854,481],[1854,522],[146,522]],"region":{"top_left_x":146,"top_left_y":481,"width":1709,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d150681e7f634ebb8960ab12b43d7321","type":"text","conversion_output":true,"text":"BPTx early benefits, and will provide information on the natural course of OAB symptoms in the early","text_display":" BPTx early benefits, and will provide information on the natural course of OAB symptoms in the early","confidence":1,"confidence_rate":1},{"cnt":[[146,524],[1949,524],[1949,569],[146,569]],"region":{"top_left_x":146,"top_left_y":524,"width":1803,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2f4ad3c6ed84163bb420b9a0d28f246","type":"text","conversion_output":true,"text":"postoperative period which is important for clinical counseling and decision-making. Any subjects receiving","text_display":" postoperative period which is important for clinical counseling and decision-making. Any subjects receiving","confidence":1,"confidence_rate":1},{"cnt":[[146,567],[1669,567],[1669,610],[146,610]],"region":{"top_left_x":146,"top_left_y":567,"width":1524,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bd918b5ac764c869aa6994176ebd76c","type":"text","conversion_output":true,"text":"additional treatment prior to the 3 month time point will be considered a protocol deviation.","text_display":" additional treatment prior to the 3 month time point will be considered a protocol deviation.","confidence":1,"confidence_rate":1},{"cnt":[[271,610],[1972,610],[1972,655],[271,655]],"region":{"top_left_x":270,"top_left_y":610,"width":1703,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5539e115acd4c2ba73d326080cabaee","type":"text","conversion_output":true,"text":"In the event that a randomized participant decides not to undergo surgery but then later changes her","text_display":"\n\nIn the event that a randomized participant decides not to undergo surgery but then later changes her","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[1968,655],[1968,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1822,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8533232d9c6241c197fa4e99c6c5ac81","type":"text","conversion_output":true,"text":"mind and has MUS surgery, the surgery will be considered additional treatment. For purposes of calculating","text_display":" mind and has MUS surgery, the surgery will be considered additional treatment. For purposes of calculating","confidence":1,"confidence_rate":1},{"cnt":[[146,698],[1704,698],[1704,741],[146,741]],"region":{"top_left_x":146,"top_left_y":698,"width":1558,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c1bb620eb7745c7b39d6cc8c4d5144d","type":"text","conversion_output":true,"text":"follow up windows, the date of the original planned surgery that did not occur will be Time 0.","text_display":" follow up windows, the date of the original planned surgery that did not occur will be Time 0.","confidence":0.9941432476043701,"confidence_rate":0.9999400633224917},{"cnt":[[271,743],[1858,743],[1858,786],[271,786]],"region":{"top_left_x":270,"top_left_y":743,"width":1589,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6400e7ec8b1d4976890f765a10a24ef0","type":"text","conversion_output":true,"text":"Subjects who initiate additional treatment will be asked to complete all primary and secondary","text_display":"\n\nSubjects who initiate additional treatment will be asked to complete all primary and secondary","confidence":1,"confidence_rate":1},{"cnt":[[146,786],[1884,786],[1884,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1739,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1ffd9a5de7f4ceda34458daa0469b4e","type":"text","conversion_output":true,"text":"outcome measures prior to initiation of additional treatment. The type of additional treatment will not be","text_display":" outcome measures prior to initiation of additional treatment. The type of additional treatment will not be","confidence":1,"confidence_rate":1},{"cnt":[[146,829],[1962,829],[1962,874],[146,874]],"region":{"top_left_x":146,"top_left_y":829,"width":1816,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a20dfcdf21af4fca9b460ac21edbdfbf","type":"text","conversion_output":true,"text":"limited and will be left to the physician's clinical judgment. This may include (but is not limited to) behavioral","text_display":" limited and will be left to the physician's clinical judgment. This may include (but is not limited to) behavioral","confidence":1,"confidence_rate":1},{"cnt":[[146,872],[1833,872],[1833,917],[146,917]],"region":{"top_left_x":146,"top_left_y":872,"width":1687,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab972c8512d44950b87778bd505dc837","type":"text","conversion_output":true,"text":"and/or pelvic floor therapy, continence pessary, medical therapy, other procedure-based treatments","text_display":" and/or pelvic floor therapy, continence pessary, medical therapy, other procedure-based treatments","confidence":1,"confidence_rate":1},{"cnt":[[146,920],[1674,920],[1674,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1528,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3e43e8f6a8d4d96a022e2012a75e5b4","type":"text","conversion_output":true,"text":"(posterior tibial nerve stimulation, Botox), and surgical (sling revision, re-placement, sacral","text_display":" (posterior tibial nerve stimulation, Botox), and surgical (sling revision, re-placement, sacral","confidence":1,"confidence_rate":1},{"cnt":[[146,962],[1897,962],[1897,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":962,"width":1752,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ff4d161ffdf40caa227e740891fd3e6","type":"text","conversion_output":true,"text":"neuromodulation). Statistical models designed to specifically account for subjects who initiate additional","text_display":" neuromodulation). Statistical models designed to specifically account for subjects who initiate additional","confidence":1,"confidence_rate":1},{"cnt":[[146,1005],[1858,1005],[1858,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1005,"width":1713,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5500f297a48f4cc29ca596b9fd342445","type":"text","conversion_output":true,"text":"treatment will be used. Please see Section 6, Statistical Considerations section for details on how the","text_display":" treatment will be used. Please see Section 6, Statistical Considerations section for details on how the","confidence":1,"confidence_rate":1},{"cnt":[[146,1051],[1931,1051],[1931,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1050,"width":1786,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"349baed63973439c952bed342d9e979b","type":"text","conversion_output":true,"text":"analysis of primary and secondary outcomes measured at 1 year will account for any additional treatment","text_display":" analysis of primary and secondary outcomes measured at 1 year will account for any additional treatment","confidence":0.99853515625,"confidence_rate":0.9999867936215969},{"cnt":[[146,1094],[1308,1094],[1308,1137],[146,1137]],"region":{"top_left_x":146,"top_left_y":1093,"width":1163,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6aca4fed9c664a42b9306ed54a51e938","type":"text","conversion_output":true,"text":"requests for SUI and/or OAB if initiated prior to the 1 year time point.","text_display":" requests for SUI and/or OAB if initiated prior to the 1 year time point.","confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[144,1220],[621,1220],[621,1270],[144,1270]],"region":{"top_left_x":143,"top_left_y":1220,"width":478,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82f4fe7e46154c0483087785abf8165b","type":"section_header","conversion_output":false,"children_ids":["ac420af9333348bea4af341699030de2"],"text":"","text_display":""},{"cnt":[[146,1225],[617,1225],[617,1265],[146,1265]],"region":{"top_left_x":146,"top_left_y":1224,"width":471,"height":42},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac420af9333348bea4af341699030de2","type":"text","conversion_output":true,"parent_id":"82f4fe7e46154c0483087785abf8165b","text":"3.4.2. Secondary outcomes","text_display":"\n\n\\subsection*{3.4.2. Secondary outcomes}","confidence":0.99462890625,"confidence_rate":0.999820497114818},{"cnt":[[271,1276],[1940,1276],[1940,1321],[271,1321]],"region":{"top_left_x":270,"top_left_y":1276,"width":1671,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b94c695c8fbb492799f7a9b5bdc6abf9","type":"text","conversion_output":true,"text":"Consistent with Brubaker et al who emphasized the importance of characterizing the OAB and SUI","text_display":"\n\nConsistent with Brubaker et al who emphasized the importance of characterizing the OAB and SUI","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[146,1319],[1970,1319],[1970,1364],[146,1364]],"region":{"top_left_x":146,"top_left_y":1319,"width":1825,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c219632bab9442e0aa03ecaa634f6ddd","type":"text","conversion_output":true,"text":"components separately for MUI populations, we will ensure adequate power of our trial to detect differences","text_display":" components separately for MUI populations, we will ensure adequate power of our trial to detect differences","confidence":1,"confidence_rate":1},{"cnt":[[146,1366],[960,1366],[960,1412],[146,1412]],"region":{"top_left_x":146,"top_left_y":1366,"width":815,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2231db1358a647c99015bcb7e5a77c21","type":"text","conversion_output":true,"text":"in OAB and SUI symptom outcomes separately.","text_display":" in OAB and SUI symptom outcomes separately.","confidence":0.827876091003418,"confidence_rate":0.9965081148543661},{"cnt":[[142,1491],[1394,1491],[1394,1540],[142,1540]],"region":{"top_left_x":141,"top_left_y":1491,"width":1254,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd10b46665d24760b2ee96a97d639224","type":"section_header","conversion_output":false,"children_ids":["178a62703e49469485ea8f5d5fda4b93"],"text":"","text_display":""},{"cnt":[[146,1495],[1390,1495],[1390,1540],[146,1540]],"region":{"top_left_x":146,"top_left_y":1495,"width":1245,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"178a62703e49469485ea8f5d5fda4b93","type":"text","conversion_output":true,"parent_id":"dd10b46665d24760b2ee96a97d639224","text":"3.4.2.a. Urge urinary incontinence/overactive bladder symptom outcomes","text_display":"\n\n\\subsection*{3.4.2.a. Urge urinary incontinence/overactive bladder symptom outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[271,1551],[1914,1551],[1914,1592],[271,1592]],"region":{"top_left_x":270,"top_left_y":1551,"width":1645,"height":41},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6768f7510114472889c93f5790a55397","type":"text","conversion_output":true,"text":"Because the primary clinical problem in this population is the potential for persistent or worsening","text_display":"\n\nBecause the primary clinical problem in this population is the potential for persistent or worsening","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[146,1594],[1869,1594],[1869,1639],[146,1639]],"region":{"top_left_x":146,"top_left_y":1594,"width":1724,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24d4c4c28c1e46cda9fd9a3df654d349","type":"text","conversion_output":true,"text":"OAB after MUS, it is highly important to capture and report on the cardinal symptoms of OAB from the","text_display":" OAB after MUS, it is highly important to capture and report on the cardinal symptoms of OAB from the","confidence":0.2812328338623047,"confidence_rate":0.9882141867985573},{"cnt":[[146,1637],[1962,1637],[1962,1682],[146,1682]],"region":{"top_left_x":146,"top_left_y":1637,"width":1816,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51703c23c1fa4215b44072d38adea7ed","type":"text","conversion_output":true,"text":"patient perspective. The UDI-irritative subscale measures symptom burden, impact, and changes related to","text_display":" patient perspective. The UDI-irritative subscale measures symptom burden, impact, and changes related to","confidence":1,"confidence_rate":1},{"cnt":[[146,1680],[1863,1680],[1863,1725],[146,1725]],"region":{"top_left_x":146,"top_left_y":1680,"width":1717,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9b57d77f64344eebc2b4e26d19e428d","type":"text","conversion_output":true,"text":"OAB which are important aspects that cannot be directly observed or otherwise measured. It is highly","text_display":" OAB which are important aspects that cannot be directly observed or otherwise measured. It is highly","confidence":0.9931640625,"confidence_rate":0.9999358954234694},{"cnt":[[146,1727],[1914,1727],[1914,1768],[146,1768]],"region":{"top_left_x":146,"top_left_y":1727,"width":1769,"height":42},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0e24528b550400d87c5058a2a3b5f4c","type":"text","conversion_output":true,"text":"responsive to treatment-related change and is able to discriminate among levels of change in all bladder","text_display":" responsive to treatment-related change and is able to discriminate among levels of change in all bladder","confidence":1,"confidence_rate":1},{"cnt":[[146,1770],[1946,1770],[1946,1813],[146,1813]],"region":{"top_left_x":146,"top_left_y":1770,"width":1801,"height":44},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53a0512f7182469f803d3af7513b5dd1","type":"text","conversion_output":true,"text":"diary variables (urinary urgency, frequency and urge incontinence) and patient ratings of treatment benefit.","text_display":" diary variables (urinary urgency, frequency and urge incontinence) and patient ratings of treatment benefit.","confidence":1,"confidence_rate":1},{"cnt":[[146,1813],[1923,1813],[1923,1858],[146,1858]],"region":{"top_left_x":146,"top_left_y":1813,"width":1777,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64a52d5c5d3a4ab3912a2c436c94e7a8","type":"text","conversion_output":true,"text":"Particularly for ESTEEM, this comprehensive OAB measure will be important to understanding how MUS","text_display":" Particularly for ESTEEM, this comprehensive OAB measure will be important to understanding how MUS","confidence":1,"confidence_rate":1},{"cnt":[[146,1856],[1128,1856],[1128,1901],[146,1901]],"region":{"top_left_x":146,"top_left_y":1856,"width":982,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60cbf6709d174330a2ec916d2b8ae3ad","type":"text","conversion_output":true,"text":"may affect all OAB symptoms individually and as a whole.","text_display":" may affect all OAB symptoms individually and as a whole.","confidence":0.96044921875,"confidence_rate":0.9993978803353464},{"cnt":[[142,1983],[1098,1983],[1098,2032],[142,2032]],"region":{"top_left_x":141,"top_left_y":1983,"width":957,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ba2bb1c2da44234b50a30eda88a32f8","type":"section_header","conversion_output":false,"children_ids":["fb52698e8ab04a3399d774e13878d19b"],"text":"","text_display":""},{"cnt":[[146,1985],[1094,1985],[1094,2030],[146,2030]],"region":{"top_left_x":146,"top_left_y":1985,"width":948,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb52698e8ab04a3399d774e13878d19b","type":"text","conversion_output":true,"parent_id":"6ba2bb1c2da44234b50a30eda88a32f8","text":"3.4.2.b. Stress urinary incontinence symptom outcomes","text_display":"\n\n\\subsection*{3.4.2.b. Stress urinary incontinence symptom outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[271,2041],[1974,2041],[1974,2086],[271,2086]],"region":{"top_left_x":270,"top_left_y":2041,"width":1705,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bce5f36be72843f4869408f4a211faf0","type":"text","conversion_output":true,"text":"It is also important to be able to report on SUI outcomes separately. The majority of studies have not","text_display":"\n\nIt is also important to be able to report on SUI outcomes separately. The majority of studies have not","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[146,2084],[1953,2084],[1953,2129],[146,2129]],"region":{"top_left_x":146,"top_left_y":2083,"width":1807,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08800f62ac914e64b257a96fbc614f65","type":"text","conversion_output":true,"text":"demonstrated significant differences in efficacy for SUI outcomes for subjects who had MUI preoperatively;","text_display":" demonstrated significant differences in efficacy for SUI outcomes for subjects who had MUI preoperatively;","confidence":1,"confidence_rate":1},{"cnt":[[146,2127],[1916,2127],[1916,2172],[146,2172]],"region":{"top_left_x":146,"top_left_y":2126,"width":1771,"height":47},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f797da1e08147388a9ecbff5a89b519","type":"text","conversion_output":true,"text":"however the majority of studies only had small subsets of women with MUI. Two studies have suggested","text_display":" however the majority of studies only had small subsets of women with MUI. Two studies have suggested","confidence":1,"confidence_rate":1},{"cnt":[[146,2172],[1876,2172],[1876,2217],[146,2217]],"region":{"top_left_x":146,"top_left_y":2172,"width":1730,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7eed80d58e8425fb39f3f158011c163","type":"text","conversion_output":true,"text":"worse SUI outcomes in women with MUI at baseline (see section 2.4 above). One study by Paick et al","text_display":" worse SUI outcomes in women with MUI at baseline (see section 2.4 above). One study by Paick et al","confidence":1,"confidence_rate":1},{"cnt":[[146,2217],[1923,2217],[1923,2262],[146,2262]],"region":{"top_left_x":146,"top_left_y":2217,"width":1777,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"499bca2916704f958fd5b46ef0df15a8","type":"text","conversion_output":true,"text":"evaluated 274 women, of which 73 had MUI and reported cure rates for SUI to be \\(78 \\%\\) for the MUI group","text_display":" evaluated 274 women, of which 73 had MUI and reported cure rates for SUI to be \\(78 \\%\\) for the MUI group","confidence":1,"confidence_rate":1},{"cnt":[[146,2258],[1858,2258],[1858,2305],[146,2305]],"region":{"top_left_x":146,"top_left_y":2258,"width":1713,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b07fa7c30cd24a2eb5ad6d2c394b48bc","type":"text","conversion_output":true,"text":"and \\(95 \\%\\) for the pure SUI group. \\({ }^{57}\\) They also reported that maximal urethral pressure at baseline was","text_display":" and \\(95 \\%\\) for the pure SUI group. \\({ }^{57}\\) They also reported that maximal urethral pressure at baseline was","confidence":1,"confidence_rate":1},{"cnt":[[146,2305],[1779,2305],[1779,2348],[146,2348]],"region":{"top_left_x":146,"top_left_y":2305,"width":1633,"height":44},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36c3c020a7bf48ae9beec4441d0cedbb","type":"text","conversion_output":true,"text":"associated with a greater risk of persistent OAB , suggesting the possibility that profound urethral","text_display":" associated with a greater risk of persistent OAB , suggesting the possibility that profound urethral","confidence":0.61474609375,"confidence_rate":0.9956262957589137},{"cnt":[[146,2348],[1962,2348],[1962,2391],[146,2391]],"region":{"top_left_x":146,"top_left_y":2348,"width":1816,"height":44},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77193970058a4b4cb0dfc27ab03edfa8","type":"text","conversion_output":true,"text":"dysfunction may contribute to persistent symptoms. A study by Gleason et al using data from the University","text_display":" dysfunction may contribute to persistent symptoms. A study by Gleason et al using data from the University","confidence":1,"confidence_rate":1},{"cnt":[[146,2393],[1946,2393],[1946,2436],[146,2436]],"region":{"top_left_x":146,"top_left_y":2393,"width":1801,"height":44},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b59f747d2ed6490cad8b36375a6e60af","type":"text","conversion_output":true,"text":"of Alabama including 534 women with MUS found that women with MUI had higher rates of SUI compared","text_display":" of Alabama including 534 women with MUS found that women with MUI had higher rates of SUI compared","confidence":1,"confidence_rate":1},{"cnt":[[146,2436],[1919,2436],[1919,2481],[146,2481]],"region":{"top_left_x":146,"top_left_y":2436,"width":1773,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63b0a633ba2141b79383c8c95ceb5c3d","type":"text","conversion_output":true,"text":"to women with SUI only ( \\(36 \\%\\) vs \\(16 \\%, p <.001\\) ) with an adjusted OR \\(=2.7\\) ( \\(95 \\% CI 1.7,4.2\\) ) (unpublished","text_display":" to women with SUI only ( \\(36 \\%\\) vs \\(16 \\%, p <.001\\) ) with an adjusted OR \\(=2.7\\) ( \\(95 \\% CI 1.7,4.2\\) ) (unpublished","confidence":0.5589181885407353,"confidence_rate":0.9952428906498212},{"cnt":[[146,2479],[1828,2479],[1828,2524],[146,2524]],"region":{"top_left_x":146,"top_left_y":2479,"width":1683,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fb3ff20b85547499e0164c5adb7e618","type":"text","conversion_output":true,"text":"data). In addition, because BPTx can also treat SUI, it is important to know if women randomized to","text_display":" data). In addition, because BPTx can also treat SUI, it is important to know if women randomized to","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c38ba07bf45e44018c87a5fcc7961bc9","type":"page_info","conversion_output":false,"text":"20","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55e9fb8b528a40d58a46a292f5a1edc9","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-21","page":21,"lines":[{"cnt":[[146,129],[408,129],[408,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":263,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"348af83795b641e1b3f221dbe94852b8","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a64fd3ccdc246dcaf5a66db4bf34c52","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40ee587d4d0a473cbb910cf8408423d8","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,256],[146,256]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1f65db0fb5444cca545786fabc8bd4a","type":"section_header","conversion_output":false,"children_ids":["b5cb1241bdf84ef693c3feef34952aed"],"text":"","text_display":""},{"cnt":[[150,215],[354,215],[354,251],[150,251]],"region":{"top_left_x":150,"top_left_y":214,"width":205,"height":38},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5cb1241bdf84ef693c3feef34952aed","type":"text","conversion_output":true,"parent_id":"f1f65db0fb5444cca545786fabc8bd4a","text":"Confidential","text_display":"\n\n\\section*{Confidential}","confidence":1,"confidence_rate":1},{"cnt":[[148,262],[1914,262],[1914,303],[148,303]],"region":{"top_left_x":148,"top_left_y":262,"width":1767,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86e695d5146642d787566a379a337212","type":"text","conversion_output":true,"text":"MUS+BPTx have improved SUI symptom outcomes as well. Therefore, as a secondary outcome, we will","text_display":"\n\nMUS+BPTx have improved SUI symptom outcomes as well. Therefore, as a secondary outcome, we will","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1811,305],[1811,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1666,"height":41},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c23981f37ab4cc0b5bc11c73efcf7df","type":"text","conversion_output":true,"text":"also compare SUI outcomes between women randomized to MUS + BPTx versus MUS alone. SUI","text_display":" also compare SUI outcomes between women randomized to MUS + BPTx versus MUS alone. SUI","confidence":0.9990234375,"confidence_rate":0.9999892633582115},{"cnt":[[146,348],[1149,348],[1149,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1004,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d6f938cfd884005a18ca228c034ef34","type":"text","conversion_output":true,"text":"symptoms will be measured using the UDI-stress subscale.","text_display":" symptoms will be measured using the UDI-stress subscale.","confidence":1,"confidence_rate":1},{"cnt":[[146,432],[535,432],[535,477],[146,477]],"region":{"top_left_x":146,"top_left_y":431,"width":389,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed1a485cbfc242f396cab0b45acab425","type":"section_header","conversion_output":false,"children_ids":["e7cbbc5e2dc146cd897c23819e91ecbc"],"text":"","text_display":""},{"cnt":[[148,434],[531,434],[531,473],[148,473]],"region":{"top_left_x":148,"top_left_y":433,"width":383,"height":40},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7cbbc5e2dc146cd897c23819e91ecbc","type":"text","conversion_output":true,"parent_id":"ed1a485cbfc242f396cab0b45acab425","text":"3.4.3. Other outcomes","text_display":"\n\n\\subsection*{3.4.3. Other outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[146,516],[733,516],[733,561],[146,561]],"region":{"top_left_x":146,"top_left_y":515,"width":587,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c78a73aaf2744e989ab65bc13031982","type":"section_header","conversion_output":false,"children_ids":["6455a7c66ea84df9b0f188445d5e29a6"],"text":"","text_display":""},{"cnt":[[148,520],[728,520],[728,559],[148,559]],"region":{"top_left_x":148,"top_left_y":519,"width":581,"height":40},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6455a7c66ea84df9b0f188445d5e29a6","type":"text","conversion_output":true,"parent_id":"5c78a73aaf2744e989ab65bc13031982","text":"3.4.3.a. Other UUI/OAB outcomes","text_display":"\n\n\\subsection*{3.4.3.a. Other UUI/OAB outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[271,571],[1957,571],[1957,617],[271,617]],"region":{"top_left_x":270,"top_left_y":571,"width":1688,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86a5a8b0a10e4a0ca3807a9fbfa32e00","type":"text","conversion_output":true,"text":"i. Bladder diary - We will assess the change in IE frequency and type, number of urgency episodes,","text_display":"\ni. Bladder diary - We will assess the change in IE frequency and type, number of urgency episodes,","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[146,619],[1897,619],[1897,662],[146,662]],"region":{"top_left_x":146,"top_left_y":618,"width":1752,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bed3f30414fc4391a0de600d68369008","type":"text","conversion_output":true,"text":"urgency severity with voids, number of diurnal voids, and number of nocturnal voids and compare these","text_display":" urgency severity with voids, number of diurnal voids, and number of nocturnal voids and compare these","confidence":1,"confidence_rate":1},{"cnt":[[146,662],[999,662],[999,707],[146,707]],"region":{"top_left_x":146,"top_left_y":661,"width":854,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af7d68454f3a44d699f91ea71a9f1c59","type":"text","conversion_output":true,"text":"variables between groups at 6 months and 1 year.","text_display":" variables between groups at 6 months and 1 year.","confidence":1,"confidence_rate":1},{"cnt":[[271,748],[1794,748],[1794,793],[271,793]],"region":{"top_left_x":270,"top_left_y":747,"width":1524,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dffe4aa5ee874d6887d88324923d4649","type":"text","conversion_output":true,"text":"ii. Overactive Bladder treatment satisfaction (OAB-SAT-q) \\({ }^{58}\\)-The OAB-SAT-q is an 11 item","text_display":"\nii. Overactive Bladder treatment satisfaction (OAB-SAT-q) \\({ }^{58}\\)-The OAB-SAT-q is an 11 item","confidence":0.998046875,"confidence_rate":0.9999817288133145},{"cnt":[[146,795],[1966,795],[1966,836],[146,836]],"region":{"top_left_x":146,"top_left_y":794,"width":1820,"height":42},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6477953decb44b197e07493a1636847","type":"text","conversion_output":true,"text":"instrument designed to assess patient satisfaction with treatment in a clinical setting. There are three 3 -item","text_display":" instrument designed to assess patient satisfaction with treatment in a clinical setting. There are three 3 -item","confidence":0.9960973262786865,"confidence_rate":0.9999674146223794},{"cnt":[[146,838],[1861,838],[1861,879],[146,879]],"region":{"top_left_x":146,"top_left_y":837,"width":1715,"height":42},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f559c49a206e4a7188c30ebb54cd138d","type":"text","conversion_output":true,"text":"subscales (Satisfaction, Side Effects, Endorsement) and two single items (Convenience, Preference).","text_display":" subscales (Satisfaction, Side Effects, Endorsement) and two single items (Convenience, Preference).","confidence":1,"confidence_rate":1},{"cnt":[[148,881],[1747,881],[1747,924],[148,924]],"region":{"top_left_x":148,"top_left_y":880,"width":1599,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9873656857cf457e99c677afb4166762","type":"text","conversion_output":true,"text":"Response options are presented on 4-, 5-, and 6-point Likert scales. It has demonstrated good","text_display":" Response options are presented on 4-, 5-, and 6-point Likert scales. It has demonstrated good","confidence":0.9809746742248535,"confidence_rate":0.9998040127178683},{"cnt":[[146,924],[1876,924],[1876,969],[146,969]],"region":{"top_left_x":146,"top_left_y":923,"width":1730,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4361e8b1446f400b96b1118b0fc59f2f","type":"text","conversion_output":true,"text":"psychometric properties in OAB/UUI patients receiving anticholinergic and anticholinergic + behavioral","text_display":" psychometric properties in OAB/UUI patients receiving anticholinergic and anticholinergic + behavioral","confidence":0.8365845680236816,"confidence_rate":0.9983338413038187},{"cnt":[[146,969],[1919,969],[1919,1012],[146,1012]],"region":{"top_left_x":146,"top_left_y":968,"width":1773,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"284925e559a54897b20163dd35ecc60d","type":"text","conversion_output":true,"text":"therapies. We will compare change from baseline in OAB-SAT-q scores at 6 months and 1 year between","text_display":" therapies. We will compare change from baseline in OAB-SAT-q scores at 6 months and 1 year between","confidence":0.9965860823871253,"confidence_rate":0.9999686265625553},{"cnt":[[146,1014],[449,1014],[449,1055],[146,1055]],"region":{"top_left_x":146,"top_left_y":1014,"width":304,"height":41},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"485dd7f6c75a42ec817a097c8041f563","type":"text","conversion_output":true,"text":"treatment groups.","text_display":" treatment groups.","confidence":1,"confidence_rate":1},{"cnt":[[271,1100],[1869,1100],[1869,1145],[271,1145]],"region":{"top_left_x":270,"top_left_y":1100,"width":1600,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4200564dc364eb4a84d45122c51eebb","type":"text","conversion_output":true,"text":"iii. Overactive Bladder Questionnaire-Symptom subscale (OAB-q) - The OAB-q is a validated,","text_display":"\niii. Overactive Bladder Questionnaire-Symptom subscale (OAB-q) - The OAB-q is a validated,","confidence":0.97265625,"confidence_rate":0.9997082052328516},{"cnt":[[146,1145],[1899,1145],[1899,1188],[146,1188]],"region":{"top_left_x":146,"top_left_y":1145,"width":1754,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2707facfcc524c4c96b6212dbe08f51a","type":"text","conversion_output":true,"text":"responsive questionnaire that includes 8 symptom bother items (SS) and 25 health related quality of life","text_display":" responsive questionnaire that includes 8 symptom bother items (SS) and 25 health related quality of life","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[148,1188],[1938,1188],[1938,1231],[148,1231]],"region":{"top_left_x":148,"top_left_y":1188,"width":1790,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf6efdf92c8e48ebb602d4dc64e915b6","type":"text","conversion_output":true,"text":"(HRQOL) items of 4 subscales (coping, concern, sleep, and social interaction). \\({ }^{55}\\) In a systematic review of","text_display":" (HRQOL) items of 4 subscales (coping, concern, sleep, and social interaction). \\({ }^{55}\\) In a systematic review of","confidence":1,"confidence_rate":1},{"cnt":[[148,1233],[1923,1233],[1923,1274],[148,1274]],"region":{"top_left_x":148,"top_left_y":1233,"width":1775,"height":42},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"457feb30136c489aa7e6279b71c16d8b","type":"text","conversion_output":true,"text":"UI questionnaires by Avery et al, the OAB-q was rated as \"grade A\", highest recommendation specifically","text_display":" UI questionnaires by Avery et al, the OAB-q was rated as \"grade A\", highest recommendation specifically","confidence":0.96875,"confidence_rate":0.9997060737759401},{"cnt":[[146,1276],[1906,1276],[1906,1319],[146,1319]],"region":{"top_left_x":146,"top_left_y":1276,"width":1760,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b8ea8e932fc41de99fc27760c142f4b","type":"text","conversion_output":true,"text":"for OAB symptoms. \\({ }^{59}\\) Each item is rated on a 6-point Likert scale ranging from \"not at all bothered\" to \"a","text_display":" for OAB symptoms. \\({ }^{59}\\) Each item is rated on a 6-point Likert scale ranging from \"not at all bothered\" to \"a","confidence":1,"confidence_rate":1},{"cnt":[[146,1319],[1904,1319],[1904,1364],[146,1364]],"region":{"top_left_x":146,"top_left_y":1319,"width":1758,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"843c3cb0f88742ba870aab45d6b559a9","type":"text","conversion_output":true,"text":"very great deal bothered\" for symptom items and \"none of the time\" to \"all of the time\" for HRQOL items.","text_display":" very great deal bothered\" for symptom items and \"none of the time\" to \"all of the time\" for HRQOL items.","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[148,1364],[1807,1364],[1807,1407],[148,1407]],"region":{"top_left_x":148,"top_left_y":1364,"width":1659,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3485a56fae6443d394d876b22056f4c1","type":"text","conversion_output":true,"text":"Subscales are summed and transformed into scores ranging from 0-100 with higher bother scores","text_display":" Subscales are summed and transformed into scores ranging from 0-100 with higher bother scores","confidence":0.91845703125,"confidence_rate":0.9991324157847356},{"cnt":[[146,1405],[1949,1405],[1949,1450],[146,1450]],"region":{"top_left_x":146,"top_left_y":1405,"width":1803,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56ccb8f7393e4f73bd5b96fd673ed6c8","type":"text","conversion_output":true,"text":"indicating increasing symptom bother and higher HRQOL scores indicating better quality of life. \\({ }^{60,61}\\) We will","text_display":" indicating increasing symptom bother and higher HRQOL scores indicating better quality of life. \\({ }^{60,61}\\) We will","confidence":0.99560546875,"confidence_rate":0.9999644827631314},{"cnt":[[146,1452],[1828,1452],[1828,1497],[146,1497]],"region":{"top_left_x":146,"top_left_y":1452,"width":1683,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0700b67ab04745329937fac367f0b18b","type":"text","conversion_output":true,"text":"compare change from baseline in OAB-q scores at 6 months and 1 year between treatment groups.","text_display":" compare change from baseline in OAB-q scores at 6 months and 1 year between treatment groups.","confidence":0.9800305366516113,"confidence_rate":0.9998060616166109},{"cnt":[[144,1577],[535,1577],[535,1622],[144,1622]],"region":{"top_left_x":143,"top_left_y":1576,"width":392,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8961cbcca9d94d57bc1a0eaa179db452","type":"section_header","conversion_output":false,"children_ids":["fd58ef1856ed4d88befd6c7badb8a3de"],"text":"","text_display":""},{"cnt":[[146,1581],[535,1581],[535,1620],[146,1620]],"region":{"top_left_x":146,"top_left_y":1581,"width":389,"height":39},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd58ef1856ed4d88befd6c7badb8a3de","type":"text","conversion_output":true,"parent_id":"8961cbcca9d94d57bc1a0eaa179db452","text":"3.4.3.b. Time to failure","text_display":"\n\n\\subsection*{3.4.3.b. Time to failure}","confidence":1,"confidence_rate":1},{"cnt":[[271,1637],[1974,1637],[1974,1678],[271,1678]],"region":{"top_left_x":270,"top_left_y":1637,"width":1705,"height":41},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4575b5cf24f4ff18608e46bbbcba123","type":"text","conversion_output":true,"text":"For analyzing time to failure, \"failure\" will be defined as initiation of any additional treatment for either","text_display":"\n\nFor analyzing time to failure, \"failure\" will be defined as initiation of any additional treatment for either","confidence":1,"confidence_rate":1},{"cnt":[[148,1680],[1906,1680],[1906,1723],[148,1723]],"region":{"top_left_x":148,"top_left_y":1680,"width":1758,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1dcaa42acb6a4fafb07286d293cd1062","type":"text","conversion_output":true,"text":"SUI or UUI/OAB symptoms during the follow-up period. Subjects lost to follow up will be censored at the","text_display":" SUI or UUI/OAB symptoms during the follow-up period. 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However, because this is a subjective","text_display":" Brink score in many previous studies, including Network studies. However, because this is a subjective","confidence":1,"confidence_rate":1},{"cnt":[[146,436],[1888,436],[1888,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1743,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd5aa27e4e0b411d84600f60246a67aa","type":"text","conversion_output":true,"text":"measure, it may be subject to bias. Although there are many trials showing symptom improvement with","text_display":" measure, it may be subject to bias. Although there are many trials showing symptom improvement with","confidence":1,"confidence_rate":1},{"cnt":[[146,477],[1846,477],[1846,524],[146,524]],"region":{"top_left_x":146,"top_left_y":476,"width":1700,"height":49},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffe116ac95da41e8903496eb841913f7","type":"text","conversion_output":true,"text":"pelvic floor therapy \\({ }^{20}\\), there are limited studies evaluating the association between PFM strength and","text_display":" pelvic floor therapy \\({ }^{20}\\), there are limited studies evaluating the association between PFM strength and","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[146,524],[1794,524],[1794,569],[146,569]],"region":{"top_left_x":146,"top_left_y":524,"width":1648,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aadc46eca51246969e8b7ec16ac0d1d9","type":"text","conversion_output":true,"text":"improvements in UI symptoms. To contribute to the literature about this issue, in ESTEEM we will","text_display":" improvements in UI symptoms. To contribute to the literature about this issue, in ESTEEM we will","confidence":0.99755859375,"confidence_rate":0.9999757983983905},{"cnt":[[146,567],[1828,567],[1828,612],[146,612]],"region":{"top_left_x":146,"top_left_y":567,"width":1683,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32258038deea4db1be512638fc5f101e","type":"text","conversion_output":true,"text":"objectively assess PFM strength changes using the Peritron Perineometer. Peritron is an advanced","text_display":" objectively assess PFM strength changes using the Peritron Perineometer. 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Pelvic floor muscle","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[1910,655],[1910,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1764,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b9056b5f6df4954951a3bd551080784","type":"text","conversion_output":true,"text":"contraction creates pressure in the sensor that is transferred and displayed on a \"Readout Unit\" which is","text_display":" contraction creates pressure in the sensor that is transferred and displayed on a \"Readout Unit\" which is","confidence":1,"confidence_rate":1},{"cnt":[[146,698],[492,698],[492,737],[146,737]],"region":{"top_left_x":146,"top_left_y":698,"width":346,"height":39},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"357d4949073a42dca59d092601f18704","type":"text","conversion_output":true,"text":"small and handheld.","text_display":" small and handheld.","confidence":1,"confidence_rate":1},{"cnt":[[146,829],[724,829],[724,870],[146,870]],"region":{"top_left_x":146,"top_left_y":829,"width":579,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d18ad0dfb10f48e3a387e73765bfa147","type":"figure_label","conversion_output":false,"text":"FIGURE 4. Peritron Perineometer","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,986],[1046,986],[1046,1439],[146,1439]],"region":{"top_left_x":146,"top_left_y":986,"width":901,"height":454},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6770763693e4a248ceff13e3de5f3d3","type":"diagram","conversion_output":true,"selected_labels":["d18ad0dfb10f48e3a387e73765bfa147","e69ac9cca51d4b468150f6cf1ebe1101"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{FIGURE 4. Peritron Perineometer}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/722dd686-9d24-4967-a9cf-6968feb8114e-22.jpg?height=454&width=901&top_left_y=986&top_left_x=146}\n\\end{figure}"},{"cnt":[[148,1439],[1362,1439],[1362,1485],[148,1485]],"region":{"top_left_x":148,"top_left_y":1439,"width":1215,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e69ac9cca51d4b468150f6cf1ebe1101","type":"figure_label","conversion_output":true,"text":"Example: Peritron 9300 Device (www.win-health.com/perineomter.html)","text_display":"\n\nExample: Peritron 9300 Device (www.win-health.com/perineomter.html)","confidence":1,"confidence_rate":1},{"cnt":[[146,1528],[1798,1528],[1798,1573],[146,1573]],"region":{"top_left_x":146,"top_left_y":1527,"width":1653,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eef20e64a75d44bc8bf60318ad82ece2","type":"text","conversion_output":true,"text":"After a thorough search of the literature and discussion with other experts in the field, the protocol","text_display":"\n\nAfter a thorough search of the literature and discussion with other experts in the field, the protocol","confidence":1,"confidence_rate":1},{"cnt":[[146,1573],[1977,1573],[1977,1618],[146,1618]],"region":{"top_left_x":146,"top_left_y":1572,"width":1831,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77287e7911554f5ea7b75fcc2ea3dcd0","type":"text","conversion_output":true,"text":"investigators concluded that the Peritron device has adequate evidence to support its validity, including test-","text_display":" investigators concluded that the Peritron device has adequate evidence to support its validity, including test","confidence":1,"confidence_rate":1},{"cnt":[[146,1616],[1729,1616],[1729,1661],[146,1661]],"region":{"top_left_x":146,"top_left_y":1615,"width":1584,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e803de943e924c209d6a2a1ada11d20c","type":"text","conversion_output":true,"text":"retest reliability and inter-rater reliability, for both baseline and maximum contraction pressure","text_display":"retest reliability and inter-rater reliability, for both baseline and maximum contraction pressure","confidence":1,"confidence_rate":1},{"cnt":[[146,1659],[1919,1659],[1919,1704],[146,1704]],"region":{"top_left_x":146,"top_left_y":1658,"width":1773,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66d807b21b7741baa29b74d763024673","type":"text","conversion_output":true,"text":"measurements. In addition, studies support its reliability in \"normal\", continent controls as well as women","text_display":" measurements. In addition, studies support its reliability in \"normal\", continent controls as well as women","confidence":1,"confidence_rate":1},{"cnt":[[146,1702],[281,1702],[281,1742],[146,1742]],"region":{"top_left_x":146,"top_left_y":1701,"width":136,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5be33dc182964f4488b56b2e00853e53","type":"text","conversion_output":true,"text":"with UI.","text_display":" with UI.","confidence":1,"confidence_rate":1},{"cnt":[[271,1747],[1846,1747],[1846,1794],[271,1794]],"region":{"top_left_x":270,"top_left_y":1746,"width":1576,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff8eb8396b7b427f9b89b8fe1a0bcadf","type":"text","conversion_output":true,"text":"Studies evaluating the Peritron's reliability properties are in Table 4. 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Measurement using the Peritron device will be standardized and Principal Investigators at","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[146,1968],[1940,1968],[1940,2013],[146,2013]],"region":{"top_left_x":146,"top_left_y":1967,"width":1795,"height":47},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e5438c775884437bf782c2c7b678003","type":"text","conversion_output":true,"text":"each site will be trained on how to use the device and will be responsible for training their clinical staff and","text_display":" each site will be trained on how to use the device and will be responsible for training their clinical staff and","confidence":1,"confidence_rate":1},{"cnt":[[146,2011],[1962,2011],[1962,2056],[146,2056]],"region":{"top_left_x":146,"top_left_y":2010,"width":1816,"height":47},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c4f9aa9c39846bc83fca256144f9581","type":"text","conversion_output":true,"text":"for quality assurance of Peritron use. Clinical staff performing the Peritron measurements will be masked to","text_display":" for quality assurance of Peritron use. Clinical staff performing the Peritron measurements will be masked to","confidence":1,"confidence_rate":1},{"cnt":[[146,2054],[1835,2054],[1835,2099],[146,2099]],"region":{"top_left_x":146,"top_left_y":2053,"width":1689,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f96cc7c7011c4eac866c669b8d3d8884","type":"text","conversion_output":true,"text":"the intervention the subject received. PFM measures (Maximum squeeze amplitude and duration of","text_display":" the intervention the subject received. PFM measures (Maximum squeeze amplitude and duration of","confidence":1,"confidence_rate":1},{"cnt":[[146,2099],[1910,2099],[1910,2142],[146,2142]],"region":{"top_left_x":146,"top_left_y":2099,"width":1764,"height":43},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63bce66fd0544b438a75c91ddbecad30","type":"text","conversion_output":true,"text":"squeeze), will be performed at baseline, at the first post-operative visit after surgery ( 2 weeks), 8 weeks,","text_display":" squeeze), will be performed at baseline, at the first post-operative visit after surgery ( 2 weeks), 8 weeks,","confidence":1,"confidence_rate":1},{"cnt":[[146,2142],[1957,2142],[1957,2189],[146,2189]],"region":{"top_left_x":146,"top_left_y":2141,"width":1812,"height":49},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88d8aac4f2614a88a07ab3459c631d1b","type":"text","conversion_output":true,"text":"and at the primary endpoint ( 12 months) - See Assessment Table 11. Changes in squeeze measures from","text_display":" and at the primary endpoint ( 12 months) - See Assessment Table 11. 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To examine the testretest reliability of several PFM measures. \\\\\n2. To correlate findings between different measures.\n\\end{tabular} & \\begin{tabular}{l}\nPeritron Reliability: \\\\\n-ICC for max contraction = 0.97 \\\\\n-ICC for mean contraction over 5 seconds \\(=0.95\\) \\\\\n-Correlation between max force and mean contraction force over 5s = r \\(=0.95\\). \\\\\nCorrelations with other measures: \\\\\n- urine stop test r = 0.88 max force \\\\\n- digital exam r = 0.70 max force \\\\\n- pad tests \\(r =-0.33\\) and -0.28 for max\n\\end{tabular} \\\\\n\\hline Hundley et al (2005) \\({ }^{64}\\) & 100 & \\begin{tabular}{l}\nMean age 48 (22 to 85) yrs \\\\\n46\\% postmenopausal\n\\end{tabular} & \\begin{tabular}{l}\n1.To compare Brink scores with Peritron measurement \\\\\n2. Determine intra- and inter-rater reliability for the Peritron.\n\\end{tabular} & \\begin{tabular}{l}\nPeritron Reliability: \\\\\n-Interrater reliability max pressure, r = 0.88 \\\\\nBrink Reliability: \\\\\n-Interrater Brink for total score = 0.68, pressure = 0.68, vertical displacement = 0.58, and squeeze duration = 0.44 \\\\\nCorrelations with other measures: \\\\\n- Brink pressure r =0.67\n\\end{tabular} \\\\\n\\hline Bo et al, \\(2005^{65}\\) & 20 & \"Normals\" PT students Mean age 25.1 (2138) yrs. & To assess whether max vaginal squeeze pressure differed when measured with 2 different sized probes. & \\begin{tabular}{l}\nPeritron Reliability: \\\\\nTest-retest: \\(r ^{2}=0.83\\)\n\\end{tabular} \\\\\n\\hline Frawley et al (2006) \\({ }^{67}\\) & 20 & \\begin{tabular}{l}\n19 female PT (1 unable to contract) \\\\\nAge range 25-65 yrs \\\\\nSome parous subjects reported mild UI and/or prolapse\n\\end{tabular} & \\begin{tabular}{l}\n1. To determine the intratherapist reliability for digital muscle testing and vaginal manometry on max voluntary contraction and endurance. \\\\\n2. To establish how reliability varied with different tools and different testing positions.\n\\end{tabular} & \\begin{tabular}{l}\nPeritron Reliability: \\\\\n-Test-retest for Max pressure: \\(r =0.91\\) to 0.96 across positions (supine lowest at 0.91). -pressure endurance \\(r =0.05\\) to 0.41with hooklying the lowest\n\\end{tabular} \\\\\n\\hline Rahmani et al (2009) \\({ }^{68}\\) & 15 & \\(20-50 yrs\\) & 1. Test-retest reliability & \\begin{tabular}{l}\nPeritron Reliability: \\\\\n-Test-retest (same day) Max pressure: ICC=. 95 \\\\\n-Test-retest (same day) Endurance: ICC=. 94 \\\\\n-Test-retest (between-days) Max pressure: ICC=. 88 \\\\\n-Test-retest (between day) Endurance: ICC=. 83\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 4. Validity properties of Peritron device}\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline Author (year) & N & Subject characteristics & Study aims & Peritron Findings \\\\\n\\hline KerschanSchindal et al (2002) \\({ }^{66}\\) & 37 & Postmenopausal all with UI (28 SUI; 5 UUI; 4 MUI) & \\begin{tabular}{l}\n1. To examine the testretest reliability of several PFM measures. \\\\\n2. To correlate findings between different measures.\n\\end{tabular} & \\begin{tabular}{l}\nPeritron Reliability: \\\\\n-ICC for max contraction = 0.97 \\\\\n-ICC for mean contraction over 5 seconds \\(=0.95\\) \\\\\n-Correlation between max force and mean contraction force over 5s = r \\(=0.95\\). \\\\\nCorrelations with other measures: \\\\\n- urine stop test r = 0.88 max force \\\\\n- digital exam r = 0.70 max force \\\\\n- pad tests \\(r =-0.33\\) and -0.28 for max\n\\end{tabular} \\\\\n\\hline Hundley et al (2005) \\({ }^{64}\\) & 100 & \\begin{tabular}{l}\nMean age 48 (22 to 85) yrs \\\\\n46\\% postmenopausal\n\\end{tabular} & \\begin{tabular}{l}\n1.To compare Brink scores with Peritron measurement \\\\\n2. 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Test-retest reliability & \\begin{tabular}{l}\nPeritron Reliability: \\\\\n-Test-retest (same day) Max pressure: ICC=. 95 \\\\\n-Test-retest (same day) Endurance: ICC=. 94 \\\\\n-Test-retest (between-days) Max pressure: ICC=. 88 \\\\\n-Test-retest (between day) Endurance: ICC=. 83\n\\end{tabular} 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We are choosing to use a general scale to calculate change in utilities (rather than","confidence":1,"confidence_rate":1},{"cnt":[[146,2344],[1824,2344],[1824,2391],[146,2391]],"region":{"top_left_x":146,"top_left_y":2343,"width":1679,"height":49},"line":90,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20cd020bc7dc45fb92da9533c394a258","type":"text","conversion_output":true,"text":"condition-specific) to allow for comparison of cost-effectiveness results with other interventions and","text_display":" condition-specific) to allow for comparison of cost-effectiveness results with other interventions and","confidence":0.9990234375,"confidence_rate":0.9999908688300274},{"cnt":[[146,2389],[312,2389],[312,2428],[146,2428]],"region":{"top_left_x":146,"top_left_y":2389,"width":166,"height":39},"line":91,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5decd0f747a4ede83185695356552d9","type":"text","conversion_output":true,"text":"diseases.","text_display":" diseases.","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":92,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c9039fbe43846cf9ee7a302c18922fb","type":"page_info","conversion_output":false,"text":"24","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d47d8565e01b4a94a5c234043025265b","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-25","page":25,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a21ef889884741468b7edb8323845e58","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c1916b0041444db89e7ccfd0d709ebf","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2628a8d6aef47dfb875c39f8669d9f4","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"706ee0a08eed41f197a08827631c1cdb","type":"text","conversion_output":true,"text":"Confidential","text_display":"\n\nConfidential","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1944,260],[1944,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1799,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc40ba1143e043be9294c0b8aa628e46","type":"text","conversion_output":true,"text":"A questionnaire to measure direct non-medical costs (e.g. pads, laundry) and indirect costs (e.g. time, lost","text_display":"\nA questionnaire to measure direct non-medical costs (e.g. pads, laundry) and indirect costs (e.g. time, lost","confidence":1,"confidence_rate":1},{"cnt":[[146,301],[1936,301],[1936,346],[146,346]],"region":{"top_left_x":146,"top_left_y":300,"width":1790,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6dfe5ef8468c48f7923280aada81559b","type":"text","conversion_output":true,"text":"productivity) will be administered. Based on similar questionnaires used in SISTEr \\({ }^{17}\\) and ValUE \\({ }^{72}\\) studies,","text_display":" productivity) will be administered. Based on similar questionnaires used in SISTEr \\({ }^{17}\\) and ValUE \\({ }^{72}\\) studies,","confidence":0.934207855258137,"confidence_rate":0.99948455468753},{"cnt":[[146,348],[1951,348],[1951,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1805,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1349b84133354c5da7ce06e14ae4a73c","type":"text","conversion_output":true,"text":"this instrument should take approximately 15 minutes for a subject to complete at baseline and 3,6 and 12","text_display":" this instrument should take approximately 15 minutes for a subject to complete at baseline and 3,6 and 12","confidence":0.9946393878226445,"confidence_rate":0.9999532616851912},{"cnt":[[146,391],[286,391],[286,432],[146,432]],"region":{"top_left_x":146,"top_left_y":391,"width":140,"height":41},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7462c4f21df34739b326494f6a29ae7d","type":"text","conversion_output":true,"text":"months.","text_display":" months.","confidence":1,"confidence_rate":1},{"cnt":[[142,475],[1951,475],[1951,563],[142,563]],"region":{"top_left_x":141,"top_left_y":474,"width":1810,"height":89},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdf541b80ce54fd3a004fe128a01969f","type":"figure_label","conversion_output":false,"children_ids":["74dce27d0b384af1885ae4bf23f2dcea","eb249566061043a7bbed568391fda2f4"],"text":"","text_display":""},{"cnt":[[146,477],[1944,477],[1944,524],[146,524]],"region":{"top_left_x":146,"top_left_y":476,"width":1799,"height":49},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74dce27d0b384af1885ae4bf23f2dcea","type":"text","conversion_output":false,"parent_id":"cdf541b80ce54fd3a004fe128a01969f","text":"Table 6: Mean utility preference scores for women with urge incontinence, stress incontinence and","text_display":"","confidence":0.9639803895261139,"confidence_rate":0.999640414397839},{"cnt":[[146,524],[518,524],[518,561],[146,561]],"region":{"top_left_x":146,"top_left_y":524,"width":372,"height":37},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb249566061043a7bbed568391fda2f4","type":"text","conversion_output":false,"parent_id":"cdf541b80ce54fd3a004fe128a01969f","text":"mixed incontinence.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[127,559],[1560,559],[1560,889],[127,889]],"region":{"top_left_x":126,"top_left_y":558,"width":1434,"height":332},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c72bde647e54bd4a1b090bb6fbb0ab8","type":"table","conversion_output":true,"selected_labels":["cdf541b80ce54fd3a004fe128a01969f"],"text":"\\begin{tabular}{|l|c|c|c|c|}\n\\hline & \\begin{tabular}{c} \nUUI \\\\\n\\(n = 4 0 )\\)\n\\end{tabular} & \\begin{tabular}{c} \nMUI \\\\\n\\(( 1 0 8 )\\)\n\\end{tabular} & \\begin{tabular}{c} \nSUI \\\\\n\\(( n = 5 4 )\\)\n\\end{tabular} & p-value \\(^{\\text {a }}\\) \\\\\n\\hline HUI-3 & \\(0.78 \\pm 0.23\\) & \\(0.79 \\pm 0.24\\) & \\(0.86 \\pm 0.15\\) & 0.29 \\\\\n\\hline EQ-5D & \\(0.71 \\pm 0.23\\) & \\(0.73 \\pm 0.26\\) & \\(0.81 \\pm 0.16\\) & \\(0 . 0 2\\) \\\\\n\\hline SF-6D & \\(0.76 \\pm 0.12\\) & \\(0.74 \\pm 0.12\\) & \\(0.81 \\pm 0.11\\) & \\(0 . 0 2\\) \\\\\n\\hline VAS \\(^{\\text {b }}\\) & \\(0.78 \\pm 0.15\\) & \\(0.78 \\pm 0.16\\) & \\(0.80 \\pm 0.14\\) & 0.63 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 6: Mean utility preference scores for women with urge incontinence, stress incontinence and mixed incontinence.}\n\\begin{tabular}{|l|c|c|c|c|}\n\\hline & \\begin{tabular}{c} \nUUI \\\\\n\\(n = 4 0 )\\)\n\\end{tabular} & \\begin{tabular}{c} \nMUI \\\\\n\\(( 1 0 8 )\\)\n\\end{tabular} & \\begin{tabular}{c} \nSUI \\\\\n\\(( n = 5 4 )\\)\n\\end{tabular} & p-value \\(^{\\text {a }}\\) \\\\\n\\hline HUI-3 & \\(0.78 \\pm 0.23\\) & \\(0.79 \\pm 0.24\\) & \\(0.86 \\pm 0.15\\) & 0.29 \\\\\n\\hline EQ-5D & \\(0.71 \\pm 0.23\\) & \\(0.73 \\pm 0.26\\) & \\(0.81 \\pm 0.16\\) & \\(0 . 0 2\\) \\\\\n\\hline SF-6D & \\(0.76 \\pm 0.12\\) & \\(0.74 \\pm 0.12\\) & \\(0.81 \\pm 0.11\\) & \\(0 . 0 2\\) \\\\\n\\hline VAS \\(^{\\text {b }}\\) & \\(0.78 \\pm 0.15\\) & \\(0.78 \\pm 0.16\\) & \\(0.80 \\pm 0.14\\) & 0.63 \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.061325259299388396,"confidence_rate":0.9928494321558977},{"cnt":[[146,889],[1755,889],[1755,935],[146,935]],"region":{"top_left_x":146,"top_left_y":889,"width":1610,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64a79b58378e4153bee74871ae65bbd3","type":"text","conversion_output":true,"text":"UUI = urge incontinence SUI = stress incontinence, MUI = mixed urge and stress incontinence","text_display":"\n\nUUI = urge incontinence SUI = stress incontinence, MUI = mixed urge and stress incontinence","confidence":0.9975600242614746,"confidence_rate":0.9999745528515933},{"cnt":[[146,932],[1487,932],[1487,978],[146,978]],"region":{"top_left_x":146,"top_left_y":932,"width":1341,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28299200e7d84ccab3fa66235ce9a600","type":"text","conversion_output":true,"text":"\\({ }^{ a }\\) Kruskal Wallis \\({ }^{ b }\\) VAS scores were divided by 100 to enhance comparability","text_display":"\n\\({ }^{ a }\\) Kruskal Wallis \\({ }^{ b }\\) VAS scores were divided by 100 to enhance comparability","confidence":0.6549906549043953,"confidence_rate":0.9959396663939509},{"cnt":[[142,1016],[1953,1016],[1953,1106],[142,1106]],"region":{"top_left_x":141,"top_left_y":1016,"width":1812,"height":91},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"268bd0b8830b470a9c7e7ef31e561b7a","type":"figure_label","conversion_output":false,"children_ids":["4e9aec29ddce42fba0f261c07804436b","54174b0306d94e329e4b21935a122e2c"],"text":"","text_display":""},{"cnt":[[146,1018],[1949,1018],[1949,1068],[146,1068]],"region":{"top_left_x":146,"top_left_y":1018,"width":1803,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e9aec29ddce42fba0f261c07804436b","type":"text","conversion_output":false,"parent_id":"268bd0b8830b470a9c7e7ef31e561b7a","text":"Table 7: Utility preference score correlations with symptom severity and condition-specific HRQOL","text_display":"","confidence":0.9975595474243164,"confidence_rate":0.999976045038553},{"cnt":[[146,1070],[329,1070],[329,1102],[146,1102]],"region":{"top_left_x":146,"top_left_y":1069,"width":183,"height":34},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54174b0306d94e329e4b21935a122e2c","type":"text","conversion_output":false,"parent_id":"268bd0b8830b470a9c7e7ef31e561b7a","text":"measures","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[114,1102],[1781,1102],[1781,1412],[114,1412]],"region":{"top_left_x":113,"top_left_y":1102,"width":1669,"height":310},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92e2f8fb39e84e17b1fe81f101d46fe5","type":"table","conversion_output":true,"selected_labels":["268bd0b8830b470a9c7e7ef31e561b7a"],"text":"\\begin{tabular}{|c|c|c|c|c|}\n\\hline & HUI-3 \\(^{\\text {EQ-5D }}\\) & SF-6D & VAS \\\\\n\\hline & \\(r\\) - value \\(^{ a }\\) & \\(r\\)-value \\(^{ a }\\) & \\(r\\)-value \\(^{ a }\\) & \\(r\\)-value \\(^{ a }\\) \\\\\n\\hline PFDI-20 score & -0.32 & -0.42 & -0.37 & -0.22 \\\\\n\\hline Bladder subscore & -0.16 & -0.26 & -0.24 & -0.23 \\\\\n\\hline PFIQ-7 score & -0.45 & -0.48 & -0.50 & -0.32 \\\\\n\\hline Bladder subscore & -0.29 & -0.31 & -0.41 & -0.26 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 7: Utility preference score correlations with symptom severity and condition-specific HRQOL measures}\n\\begin{tabular}{|c|c|c|c|c|}\n\\hline & HUI-3 \\(^{\\text {EQ-5D }}\\) & SF-6D & VAS \\\\\n\\hline & \\(r\\) - value \\(^{ a }\\) & \\(r\\)-value \\(^{ a }\\) & \\(r\\)-value \\(^{ a }\\) & \\(r\\)-value \\(^{ a }\\) \\\\\n\\hline PFDI-20 score & -0.32 & -0.42 & -0.37 & -0.22 \\\\\n\\hline Bladder subscore & -0.16 & -0.26 & -0.24 & -0.23 \\\\\n\\hline PFIQ-7 score & -0.45 & -0.48 & -0.50 & -0.32 \\\\\n\\hline Bladder subscore & -0.29 & -0.31 & -0.41 & -0.26 \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.16305807141068587,"confidence_rate":0.9956705264025862},{"cnt":[[208,1409],[1944,1409],[1944,1454],[208,1454]],"region":{"top_left_x":208,"top_left_y":1409,"width":1737,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba55b3f10c93406d85a3e811213b7d39","type":"text","conversion_output":true,"text":"Lower scores on the HUI-3, EQ-5D, SF-6D and VAS represent worse utility values while higher scores","text_display":"\n\nLower scores on the HUI-3, EQ-5D, SF-6D and VAS represent worse utility values while higher scores","confidence":1,"confidence_rate":1},{"cnt":[[208,1500],[208,1451],[1970,1453],[1970,1502]],"region":{"top_left_x":208,"top_left_y":1450,"width":1763,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a6e57411560439c8a8bcc37ead298f8","type":"text","conversion_output":true,"text":"on the PFDI, ISI and PFIQ represent worse symptom severity and quality of life. \\({ }^{\\text {a }}\\) Spearman correlation","text_display":" on the PFDI, ISI and PFIQ represent worse symptom severity and quality of life. \\({ }^{\\text {a }}\\) Spearman correlation","confidence":0.8336577415466309,"confidence_rate":0.9985098626482651},{"cnt":[[142,1536],[776,1536],[776,1583],[142,1583]],"region":{"top_left_x":141,"top_left_y":1536,"width":635,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dd3a39acde24b4b9f959eaa7b507b75","type":"section_header","conversion_output":false,"children_ids":["ebebe07f5c804118993434f44bb9a722"],"text":"","text_display":""},{"cnt":[[146,1543],[771,1543],[771,1579],[146,1579]],"region":{"top_left_x":146,"top_left_y":1542,"width":626,"height":38},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebebe07f5c804118993434f44bb9a722","type":"text","conversion_output":true,"parent_id":"7dd3a39acde24b4b9f959eaa7b507b75","text":"4. SELECTION OF PARTICIPANTS","text_display":"\n\n\\section*{4. SELECTION OF PARTICIPANTS}","confidence":1,"confidence_rate":1},{"cnt":[[146,1586],[1938,1586],[1938,1631],[146,1631]],"region":{"top_left_x":146,"top_left_y":1585,"width":1792,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8977031200043cd976acbb1ff8e00c3","type":"text","conversion_output":true,"text":"Adult women aged 21 or older with bothersome MUI (defined as bothersome SUI and UUI) will be eligible.","text_display":"\n\nAdult women aged 21 or older with bothersome MUI (defined as bothersome SUI and UUI) will be eligible.","confidence":1,"confidence_rate":1},{"cnt":[[142,1710],[1070,1710],[1070,1764],[142,1764]],"region":{"top_left_x":141,"top_left_y":1710,"width":929,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b08fb63c51154f1abe932a10a947b7f5","type":"section_header","conversion_output":false,"children_ids":["2e870e18c3b9495b90be9833df5b7089"],"text":"","text_display":""},{"cnt":[[146,1714],[1068,1714],[1068,1760],[146,1760]],"region":{"top_left_x":146,"top_left_y":1714,"width":922,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e870e18c3b9495b90be9833df5b7089","type":"text","conversion_output":true,"parent_id":"b08fb63c51154f1abe932a10a947b7f5","text":"4.1. Eligibility Criteria/Rationale for inclusion/exclusion","text_display":"\n\n\\subsection*{4.1. Eligibility Criteria/Rationale for inclusion/exclusion}","confidence":1,"confidence_rate":1},{"cnt":[[142,1766],[902,1766],[902,1815],[142,1815]],"region":{"top_left_x":141,"top_left_y":1766,"width":762,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ef1445616db49898f933718e64f4277","type":"section_header","conversion_output":false,"children_ids":["f8e2d7a199184f48821eb30ddadaa8f7"],"text":"","text_display":""},{"cnt":[[146,1770],[900,1770],[900,1813],[146,1813]],"region":{"top_left_x":146,"top_left_y":1770,"width":755,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8e2d7a199184f48821eb30ddadaa8f7","type":"text","conversion_output":true,"parent_id":"3ef1445616db49898f933718e64f4277","text":"4.1.1. Defining the ESTEEM MUI population","text_display":"\n\n\\subsection*{4.1.1. Defining the ESTEEM MUI population}","confidence":1,"confidence_rate":1},{"cnt":[[271,1813],[1901,1813],[1901,1858],[271,1858]],"region":{"top_left_x":270,"top_left_y":1813,"width":1632,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41329814cf4a46db97bc7fb5be30078f","type":"text","conversion_output":true,"text":"For ESTEEM, women must demonstrate both subjective bothersome SUI and UUI and objective","text_display":"\n\nFor ESTEEM, women must demonstrate both subjective bothersome SUI and UUI and objective","confidence":1,"confidence_rate":1},{"cnt":[[146,1856],[1927,1856],[1927,1901],[146,1901]],"region":{"top_left_x":146,"top_left_y":1856,"width":1782,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bb16ef332c849b2a4e8170507196dc3","type":"text","conversion_output":true,"text":"documentation of both conditions. The team wanted to ensure that our eligibility criteria would identify the","text_display":" documentation of both conditions. The team wanted to ensure that our eligibility criteria would identify the","confidence":1,"confidence_rate":1},{"cnt":[[146,1901],[1953,1901],[1953,1946],[146,1946]],"region":{"top_left_x":146,"top_left_y":1901,"width":1807,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"789ba40100b34d159d6dbc33e14473c5","type":"text","conversion_output":true,"text":"appropriate MUI population, but wanted to avoid overly strict criteria that may hinder recruitment such as in","text_display":" appropriate MUI population, but wanted to avoid overly strict criteria that may hinder recruitment such as in","confidence":0.98876953125,"confidence_rate":0.9999009346737956},{"cnt":[[146,1946],[316,1946],[316,1983],[146,1983]],"region":{"top_left_x":146,"top_left_y":1946,"width":170,"height":38},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edaa791e9ab64e09a743b780461ec18d","type":"text","conversion_output":true,"text":"MIMOSA.","text_display":" MIMOSA.","confidence":1,"confidence_rate":1},{"cnt":[[271,1989],[1979,1989],[1979,2035],[271,2035]],"region":{"top_left_x":270,"top_left_y":1989,"width":1709,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a82310216374a40a5bbab839c619e76","type":"text","conversion_output":true,"text":"However, as already discussed, the MUI population is difficult to define. Currently, an instrument that","text_display":"\n\nHowever, as already discussed, the MUI population is difficult to define. Currently, an instrument that","confidence":1,"confidence_rate":1},{"cnt":[[146,2032],[1927,2032],[1927,2078],[146,2078]],"region":{"top_left_x":146,"top_left_y":2032,"width":1782,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e40c649b5ea49ad95d7a40661d6e32e","type":"text","conversion_output":true,"text":"can clearly segregate SUI versus UUI symptoms and assess the magnitude of bother that is predictive of","text_display":" can clearly segregate SUI versus UUI symptoms and assess the magnitude of bother that is predictive of","confidence":1,"confidence_rate":1},{"cnt":[[146,2075],[1949,2075],[1949,2121],[146,2121]],"region":{"top_left_x":146,"top_left_y":2075,"width":1803,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e42c905ea407445bb6d1d5a62f0d4701","type":"text","conversion_output":true,"text":"clinical outcomes for MUI does not exist. Therefore, defining our inclusion criteria for this MUI population is","text_display":" clinical outcomes for MUI does not exist. Therefore, defining our inclusion criteria for this MUI population is","confidence":1,"confidence_rate":1},{"cnt":[[146,2118],[1955,2118],[1955,2166],[146,2166]],"region":{"top_left_x":146,"top_left_y":2118,"width":1810,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb3bc24035294710a06ea00c6f41fc14","type":"text","conversion_output":true,"text":"critical, but we recognize that whatever criteria are selected may not be considered to be strictly \"evidence-","text_display":" critical, but we recognize that whatever criteria are selected may not be considered to be strictly \"evidence","confidence":1,"confidence_rate":1},{"cnt":[[146,2161],[277,2161],[277,2202],[146,2202]],"region":{"top_left_x":146,"top_left_y":2161,"width":132,"height":42},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce5301eca53346d4befd40ecda43dc26","type":"text","conversion_output":true,"text":"based\".","text_display":"based\".","confidence":1,"confidence_rate":1},{"cnt":[[271,2209],[1931,2209],[1931,2254],[271,2254]],"region":{"top_left_x":270,"top_left_y":2208,"width":1662,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9163fdc175c474b9747ab775dd56f9b","type":"text","conversion_output":true,"text":"We reviewed the literature on common definitions of SUI and UUI used in previous clinical trials to","text_display":"\n\nWe reviewed the literature on common definitions of SUI and UUI used in previous clinical trials to","confidence":1,"confidence_rate":1},{"cnt":[[146,2252],[1955,2252],[1955,2297],[146,2297]],"region":{"top_left_x":146,"top_left_y":2251,"width":1810,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5fff91450e04ba68a067c5776ae7429","type":"text","conversion_output":true,"text":"help determine our criteria. Trials for SUI often use a subjective report of SUI in combination with a positive","text_display":" help determine our criteria. Trials for SUI often use a subjective report of SUI in combination with a positive","confidence":1,"confidence_rate":1},{"cnt":[[146,2295],[1876,2295],[1876,2342],[146,2342]],"region":{"top_left_x":146,"top_left_y":2294,"width":1730,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3a0a60e1b6c4a4985d03b9bea9f4178","type":"text","conversion_output":true,"text":"cough stress test (CST). CST has a \\(90-100 \\%\\) test-retest reliability. \\({ }^{73}\\) For OAB and UUI, trials often use","text_display":" cough stress test (CST). CST has a \\(90-100 \\%\\) test-retest reliability. \\({ }^{73}\\) For OAB and UUI, trials often use","confidence":1,"confidence_rate":1},{"cnt":[[146,2340],[1876,2340],[1876,2385],[146,2385]],"region":{"top_left_x":146,"top_left_y":2339,"width":1730,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5b9d7c5d8384fd9bc66bf05061e1a93","type":"text","conversion_output":true,"text":"bladder diary to document the diagnosis. More invasive UDE has not been shown to predict treatment","text_display":" bladder diary to document the diagnosis. More invasive UDE has not been shown to predict treatment","confidence":1,"confidence_rate":1},{"cnt":[[146,2380],[1944,2380],[1944,2430],[146,2430]],"region":{"top_left_x":146,"top_left_y":2380,"width":1799,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12bbba4baa6e4f25a875633fb2eb6f0b","type":"text","conversion_output":true,"text":"outcomes for SUI and has a reliability similar to the \\(CST ^{72,74,75}\\). For OAB, DO is a urodynamic observation","text_display":" outcomes for SUI and has a reliability similar to the \\(CST ^{72,74,75}\\). For OAB, DO is a urodynamic observation","confidence":0.9592879067741493,"confidence_rate":0.9996675430077571},{"cnt":[[146,2426],[1979,2426],[1979,2473],[146,2473]],"region":{"top_left_x":146,"top_left_y":2425,"width":1833,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e479d3469aa4a5f8806723fc9d85f52","type":"text","conversion_output":true,"text":"but most often is not documented on UDE. \\({ }^{76}\\) There is poor agreement between OAB symptoms and DO and","text_display":" but most often is not documented on UDE. \\({ }^{76}\\) There is poor agreement between OAB symptoms and DO and","confidence":0.99853515625,"confidence_rate":0.9999871411556362},{"cnt":[[146,2471],[1876,2471],[1876,2518],[146,2518]],"region":{"top_left_x":146,"top_left_y":2470,"width":1730,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"410686c3298845b085d30c7306a2f144","type":"text","conversion_output":true,"text":"the presence of DO does not predict outcomes of a variety of OAB treatments. \\({ }^{77}\\) Therefore, trials have","text_display":" the presence of DO does not predict outcomes of a variety of OAB treatments. \\({ }^{77}\\) Therefore, trials have","confidence":0.99853515625,"confidence_rate":0.9999874708675287},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c47e0c22efd14a4db04e95e35bfe0b23","type":"page_info","conversion_output":false,"text":"25","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f26b6d5e5067436a9524d7e6de77acd3","type":"page_info","conversion_output":false,"text":"Version 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Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2aa890162794567a813659bfdb2cf20","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"acb8d7646901496c92cc8703c1d94489","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,254],[146,254]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":40},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6990f63e00674377b7d2e829f6a4bc8a","type":"section_header","conversion_output":false,"children_ids":["9d21defd64b943649947fdbea407581a"],"text":"","text_display":""},{"cnt":[[148,217],[352,217],[352,251],[148,251]],"region":{"top_left_x":148,"top_left_y":216,"width":205,"height":36},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d21defd64b943649947fdbea407581a","type":"text","conversion_output":true,"parent_id":"6990f63e00674377b7d2e829f6a4bc8a","text":"Confidential","text_display":"\n\n\\section*{Confidential}","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1846,260],[1846,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1700,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7851b662abf843e3b25a59621a859f03","type":"text","conversion_output":true,"text":"moved away from strictly using UDE parameters as criteria and similarly, we will not use strictly UDE","text_display":"\nmoved away from strictly using UDE parameters as criteria and similarly, we will not use strictly UDE","confidence":1,"confidence_rate":1},{"cnt":[[148,305],[771,305],[771,346],[148,346]],"region":{"top_left_x":148,"top_left_y":305,"width":624,"height":41},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c84791c5b4484c108843f50ddcdd14f3","type":"text","conversion_output":true,"text":"parameters as inclusion in ESTEEM.","text_display":" parameters as inclusion in ESTEEM.","confidence":1,"confidence_rate":1},{"cnt":[[271,348],[1721,348],[1721,391],[271,391]],"region":{"top_left_x":270,"top_left_y":348,"width":1451,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"058de6a4c38c45b4a32ead3e6beb35d6","type":"text","conversion_output":true,"text":"Because no single measure captures our criteria of providing subjective and objective","text_display":"\n\nBecause no single measure captures our criteria of providing subjective and objective","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1858,391],[1858,432],[146,432]],"region":{"top_left_x":146,"top_left_y":391,"width":1713,"height":41},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c688149ba5e49b28ee1e01ce678b1d3","type":"text","conversion_output":true,"text":"documentation of both conditions, we will use a combination to define MUI in ESTEEM. This includes","text_display":" documentation of both conditions, we will use a combination to define MUI in ESTEEM. This includes","confidence":1,"confidence_rate":1},{"cnt":[[146,436],[1957,436],[1957,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1812,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"137f5e4517b74e3bae367fcdf6f7df4a","type":"text","conversion_output":true,"text":"subjective documentation of at least moderately bothersome SUI and UUI on UDI, objective documentation","text_display":" subjective documentation of at least moderately bothersome SUI and UUI on UDI, objective documentation","confidence":1,"confidence_rate":1},{"cnt":[[146,481],[1549,481],[1549,522],[146,522]],"region":{"top_left_x":146,"top_left_y":481,"width":1404,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"222f9201dcc54fcfb25954266e36301e","type":"text","conversion_output":true,"text":"of both SUI and UUI on diary, and objective documentation of SUI by CST or UDE.","text_display":" of both SUI and UUI on diary, and objective documentation of SUI by CST or UDE.","confidence":1,"confidence_rate":1},{"cnt":[[271,524],[1901,524],[1901,569],[271,569]],"region":{"top_left_x":270,"top_left_y":524,"width":1632,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"803ad5f2e78f4d958c688533a9f77380","type":"text","conversion_output":true,"text":"The team reviewed bladder diary criteria for existing SUI and UUI trials (summarized in Table 8).","text_display":"\n\nThe team reviewed bladder diary criteria for existing SUI and UUI trials (summarized in Table 8).","confidence":1,"confidence_rate":1},{"cnt":[[146,567],[1775,567],[1775,610],[146,610]],"region":{"top_left_x":146,"top_left_y":567,"width":1629,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1859a75bee624ebf885a29b12c3bb5ad","type":"text","conversion_output":true,"text":"Ultimately the goal of ESTEEM is to capture those women who have MUI that are most clinically","text_display":" Ultimately the goal of ESTEEM is to capture those women who have MUI that are most clinically","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[146,610],[1916,610],[1916,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1771,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"604d13f30b7f4310b65798cdf2cf70fe","type":"text","conversion_output":true,"text":"challenging because it is unclear which to treat first and for which a MUS potentially could be efficacious,","text_display":" challenging because it is unclear which to treat first and for which a MUS potentially could be efficacious,","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[1949,655],[1949,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1803,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44aca471e60f408ba8ff09cacd583d47","type":"text","conversion_output":true,"text":"detrimental, or neutral. It is not the patient who has severe UUI who needs sacral neuromodulation that we","text_display":" detrimental, or neutral. It is not the patient who has severe UUI who needs sacral neuromodulation that we","confidence":1,"confidence_rate":1},{"cnt":[[146,700],[1828,700],[1828,741],[146,741]],"region":{"top_left_x":146,"top_left_y":700,"width":1683,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc5bf31238b64086938ac439f604ace1","type":"text","conversion_output":true,"text":"are interested in recruiting for ESTEEM. In addition, unlike previous UUI trials, because our primary","text_display":" are interested in recruiting for ESTEEM. In addition, unlike previous UUI trials, because our primary","confidence":1,"confidence_rate":1},{"cnt":[[146,743],[1906,743],[1906,786],[146,786]],"region":{"top_left_x":146,"top_left_y":743,"width":1760,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2259ccb79f7450ea7e7218db98cae95","type":"text","conversion_output":true,"text":"outcome is not defined by diary improvement, the diary will be utilized only to document the presence of","text_display":" outcome is not defined by diary improvement, the diary will be utilized only to document the presence of","confidence":1,"confidence_rate":1},{"cnt":[[146,786],[1841,786],[1841,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1696,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fae5a7a2c8446358f9a18754d8eee8c","type":"text","conversion_output":true,"text":"both SUI and UUI IEs. Therefore, the number of IEs does not have to be set \"so high\" solely to allow","text_display":" both SUI and UUI IEs. Therefore, the number of IEs does not have to be set \"so high\" solely to allow","confidence":0.998046875,"confidence_rate":0.9999813807939509},{"cnt":[[146,834],[836,834],[836,874],[146,874]],"region":{"top_left_x":146,"top_left_y":833,"width":690,"height":42},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba0e0967806b4472ab6dd005b7139308","type":"text","conversion_output":true,"text":"demonstration of outcome improvement.","text_display":" demonstration of outcome improvement.","confidence":1,"confidence_rate":1},{"cnt":[[271,877],[1934,877],[1934,917],[271,917]],"region":{"top_left_x":270,"top_left_y":876,"width":1664,"height":42},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ac7e3ea995f46b5898f3fc72f7b6b94","type":"text","conversion_output":true,"text":"Therefore the team decided that at least 2 incontinence episodes must be documented on a 3 -day","text_display":"\n\nTherefore the team decided that at least 2 incontinence episodes must be documented on a 3 -day","confidence":0.970703125,"confidence_rate":0.9997195242563108},{"cnt":[[146,920],[1957,920],[1957,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1812,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"364d38cb27d14977b4770b4b53cea888","type":"text","conversion_output":true,"text":"diary: a minimum of 1 documented episode of SUI and 1 documented episode of UUI would be appropriate","text_display":" diary: a minimum of 1 documented episode of SUI and 1 documented episode of UUI would be appropriate","confidence":1,"confidence_rate":1},{"cnt":[[146,962],[1962,962],[1962,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":962,"width":1816,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"acfa369ae7594c48a37275f860cf472a","type":"text","conversion_output":true,"text":"for documenting MUI. In addition, patients must also report at least moderate bother from both SUI and UUI","text_display":" for documenting MUI. In addition, patients must also report at least moderate bother from both SUI and UUI","confidence":1,"confidence_rate":1},{"cnt":[[146,1008],[1824,1008],[1824,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1007,"width":1679,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a159a819c784d5999906d90f0d1734f","type":"text","conversion_output":true,"text":"on the UDI to be eligible and desire surgical treatment of SUI symptoms. This will allow appropriate","text_display":" on the UDI to be eligible and desire surgical treatment of SUI symptoms. This will allow appropriate","confidence":1,"confidence_rate":1},{"cnt":[[146,1053],[1944,1053],[1944,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1052,"width":1799,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb557ec827904ae6820f46b7c345d227","type":"text","conversion_output":true,"text":"documentation of both conditions, but would not be overly strict so as to exclude women on either the mild","text_display":" documentation of both conditions, but would not be overly strict so as to exclude women on either the mild","confidence":1,"confidence_rate":1},{"cnt":[[146,1096],[668,1096],[668,1137],[146,1137]],"region":{"top_left_x":146,"top_left_y":1095,"width":523,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"515a0a51f0c24e33a0410c776563535b","type":"text","conversion_output":true,"text":"or severe end of the spectrum.","text_display":" or severe end of the spectrum.","confidence":1,"confidence_rate":1},{"cnt":[[271,1182],[1244,1182],[1244,1227],[271,1227]],"region":{"top_left_x":270,"top_left_y":1181,"width":974,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d090065dbebd4306a19b36575a310ca5","type":"section_header","conversion_output":false,"children_ids":["ffedc2773ddf4e82878a8635006666d9"],"text":"","text_display":""},{"cnt":[[271,1182],[1240,1182],[1240,1227],[271,1227]],"region":{"top_left_x":270,"top_left_y":1181,"width":970,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffedc2773ddf4e82878a8635006666d9","type":"text","conversion_output":true,"parent_id":"d090065dbebd4306a19b36575a310ca5","text":"4.1.2. Targeting a population that is distinct from TOMUS","text_display":"\n\n\\subsection*{4.1.2. Targeting a population that is distinct from TOMUS}","confidence":1,"confidence_rate":1},{"cnt":[[271,1225],[1970,1225],[1970,1270],[271,1270]],"region":{"top_left_x":270,"top_left_y":1224,"width":1701,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49e886eca7ed4c2d82388b5a867786f4","type":"text","conversion_output":true,"text":"There were significant improvements in the UDI-irritative subscale scores in the TOMUS trial. Ideally","text_display":"\n\nThere were significant improvements in the UDI-irritative subscale scores in the TOMUS trial. 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In general the MESA urge score in TOMUS was low","text_display":" difficult to detect in a population too similar to TOMUS. In general the MESA urge score in TOMUS was low","confidence":1,"confidence_rate":1},{"cnt":[[146,1358],[1897,1358],[1897,1403],[146,1403]],"region":{"top_left_x":146,"top_left_y":1357,"width":1752,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b92d068bc50447b88fa5eac88eef2b1f","type":"text","conversion_output":true,"text":"at a mean of 5 points. Requiring documentation of UUI on diary and report of at least \"moderate bother\"","text_display":" at a mean of 5 points. 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Bladder diary inclusion criteria for other relevant trials}\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline Study & Interventions & Inclusion & Final population diary characteristics & Outcome definition \\\\\n\\hline \\multicolumn{5}{|l|}{UUI trials utilizing diary for inclusion} \\\\\n\\hline Burgio-BE-DRI \\({ }^{23}\\) & Tolterodine/BPT vs Tolterodine alone & \\(\\geq 7\\) UIEs on 7-day diary and UUI>SUI on MESA & \\(1 \\%\\) UUI \\(7-13 IE / wk 1 \\% UUI \\geq 14 IE / wk 30 \\%\\) MUI \\(7-13 IE / wk 68 \\% MUI \\geq 14 IE / wk\\) & 70\\% reduction IEs, no other UUI treatment, withdrawal of antichol at 8 months \\\\\n\\hline Visco-ABC \\({ }^{78}\\) & Anticholinergic vs Botox & \\(\\geq 5\\) UIEs on 3-day diary and >50\\% UIE/IE & \\begin{tabular}{l}\nMean (SD) \\\\\nIEs/day: 5.6 (3) \\\\\nUrge IEs/day: 5.0 (2.7) \\\\\nStress IEs/day: 0.8 (1.0) \\\\\nOther IEs/day: 0.1 (.4) \\\\\nMean voids/day: 7.9 (3) \\\\\nMean voids/night: 1.6 (1.3)\n\\end{tabular} & Change in IEs on 3day diary 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Inclusion Criteria","text_display":"\n\n\\subsection*{4.2. Inclusion Criteria}","confidence":0.998046875,"confidence_rate":0.9999301797648388},{"cnt":[[150,1568],[1351,1568],[1351,1613],[150,1613]],"region":{"top_left_x":150,"top_left_y":1568,"width":1202,"height":46},"line":104,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0659f3be7174b2d8d3604ba054fc5dd","type":"text","conversion_output":true,"text":"1) Presence of both SUI and UUI on bladder diary; and \\(\\geq 2 IEs / 3\\) days","text_display":"\n1) Presence of both SUI and UUI on bladder diary; and \\(\\geq 2 IEs / 3\\) days","confidence":0.9304332733154297,"confidence_rate":0.9990640108303447},{"cnt":[[211,1611],[698,1611],[698,1656],[211,1656]],"region":{"top_left_x":210,"top_left_y":1611,"width":489,"height":46},"line":105,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8521ef417e045d78ed00a92c0a24f47","type":"text","conversion_output":true,"text":"a) \\(\\geq 1\\) Stress IE/3 day diary","text_display":"\na) \\(\\geq 1\\) Stress 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Exclusion Criteria","text_display":"\n\n\\subsection*{4.3. 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Women undergoing only rectocele repair or other repair unrelated to anterior or apical compartment","text_display":"\na) Women undergoing only rectocele repair or other repair unrelated to anterior or apical compartment","confidence":1,"confidence_rate":1},{"cnt":[[271,305],[896,305],[896,346],[271,346]],"region":{"top_left_x":270,"top_left_y":305,"width":626,"height":41},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cb5083c155443ba8445070706088bf2","type":"text","conversion_output":true,"text":"(ie: anal sphincter repair) are eligible","text_display":" (ie: anal sphincter repair) are eligible","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[1364,348],[1364,393],[146,393]],"region":{"top_left_x":146,"top_left_y":348,"width":1219,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5e6257e69834d12b3692dceea1c51b8","type":"text","conversion_output":true,"text":"3) Women undergoing hysterectomy for any indication will be excluded","text_display":"\n3) Women undergoing hysterectomy for any indication will be excluded","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[741,391],[741,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":596,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"389669e6219c4fe998b00357384377e0","type":"text","conversion_output":true,"text":"4) Active pelvic organ malignancy","text_display":"\n4) Active pelvic organ malignancy","confidence":1,"confidence_rate":1},{"cnt":[[146,438],[462,438],[462,479],[146,479]],"region":{"top_left_x":146,"top_left_y":438,"width":316,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebcab6e78904412895118388b3947eb1","type":"text","conversion_output":true,"text":"5) Age <21 years","text_display":"\n5) Age <21 years","confidence":0.99951171875,"confidence_rate":0.9999767431038692},{"cnt":[[146,481],[1747,481],[1747,522],[146,522]],"region":{"top_left_x":146,"top_left_y":481,"width":1601,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dabeceb4f9c42edb32c2a34e53bc0bb","type":"text","conversion_output":true,"text":"6) Pregnant or plans for future pregnancy in next 12 months, or within 12 months post-partum","text_display":"\n6) Pregnant or plans for future pregnancy in next 12 months, or within 12 months post-partum","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[146,524],[1755,524],[1755,567],[146,567]],"region":{"top_left_x":146,"top_left_y":524,"width":1610,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e01123f4c0984706b3f35b887821b1a9","type":"text","conversion_output":true,"text":"7) Post-void residual \\(>150 cc\\) on 2 occasions within the past 6 months, or current catheter use","text_display":"\n7) Post-void residual \\(>150 cc\\) on 2 occasions within the past 6 months, or current catheter use","confidence":0.99755859375,"confidence_rate":0.9999777785074303},{"cnt":[[146,567],[1296,567],[1296,612],[146,612]],"region":{"top_left_x":146,"top_left_y":567,"width":1150,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36ee248866d4458f848d2d6dcb1cb23e","type":"text","conversion_output":true,"text":"8) Participation in other trial that may influence results of this study","text_display":"\n8) Participation in other trial that may influence results of this study","confidence":1,"confidence_rate":1},{"cnt":[[146,610],[608,610],[608,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":463,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89e16aa825764da3bef37d245938bd41","type":"text","conversion_output":true,"text":"9) Unevaluated hematuria","text_display":"\n9) Unevaluated hematuria","confidence":1,"confidence_rate":1},{"cnt":[[148,655],[1622,655],[1622,698],[148,698]],"region":{"top_left_x":148,"top_left_y":655,"width":1475,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76356a2cff68436687931a78bf8e2d60","type":"text","conversion_output":true,"text":"10) Prior sling, synthetic mesh for prolapse, implanted nerve stimulator for incontinence","text_display":"\n10) Prior sling, synthetic mesh for prolapse, implanted nerve stimulator for incontinence","confidence":0.9415704540442675,"confidence_rate":0.9993597146235619},{"cnt":[[150,700],[1901,700],[1901,741],[150,741]],"region":{"top_left_x":150,"top_left_y":700,"width":1752,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b657b4e6f07743febebaccc0b04b394d","type":"text","conversion_output":true,"text":"11) Spinal cord injury or advanced/severe neurologic conditions including Multiple Sclerosis, Parkinsons","text_display":"\n11) Spinal cord injury or advanced/severe neurologic conditions including Multiple Sclerosis, Parkinsons","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[150,743],[1803,743],[1803,786],[150,786]],"region":{"top_left_x":150,"top_left_y":743,"width":1653,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9544b5ad1914b77b1072a8835398fe0","type":"text","conversion_output":true,"text":"12) Women on overactive bladder medication/therapy will be eligible after 3 week wash-out period","text_display":"\n12) Women on overactive bladder medication/therapy will be eligible after 3 week wash-out period","confidence":0.99462890625,"confidence_rate":0.9999482170145101},{"cnt":[[150,786],[488,786],[488,831],[150,831]],"region":{"top_left_x":150,"top_left_y":786,"width":338,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d38e091a45c34b7aa27f1f3dfd2ed3a2","type":"text","conversion_output":true,"text":"13) Non-ambulatory","text_display":"\n13) Non-ambulatory","confidence":0.99755859375,"confidence_rate":0.9998937277628692},{"cnt":[[150,831],[1111,831],[1111,874],[150,874]],"region":{"top_left_x":150,"top_left_y":831,"width":961,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28093a51da694d8a89f99e06fba03acf","type":"text","conversion_output":true,"text":"14) History of serious adverse reaction to synthetic mesh","text_display":"\n14) History of serious adverse reaction to synthetic mesh","confidence":1,"confidence_rate":1},{"cnt":[[150,877],[1949,877],[1949,917],[150,917]],"region":{"top_left_x":150,"top_left_y":876,"width":1799,"height":42},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"928e09543eb041f190c97786dd6d5522","type":"text","conversion_output":true,"text":"15) Not able to complete study assessments per clinician judgment, or not available for 12 month follow-up","text_display":"\n15) Not able to complete study assessments per clinician judgment, or not available for 12 month follow-up","confidence":1,"confidence_rate":1},{"cnt":[[150,920],[1929,920],[1929,965],[150,965]],"region":{"top_left_x":150,"top_left_y":919,"width":1780,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0109400522bd4f80b5f106a5d85be0e8","type":"text","conversion_output":true,"text":"16) Women who only report \"other IE\" on bladder diary, and do not report at minimum 1 stress and 1 urge","text_display":"\n16) Women who only report \"other IE\" on bladder diary, and do not report at minimum 1 stress and 1 urge","confidence":0.9965834617614746,"confidence_rate":0.9999699795038443},{"cnt":[[211,962],[372,962],[372,1008],[211,1008]],"region":{"top_left_x":210,"top_left_y":962,"width":162,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7dc7a1a235e4cfe93d99fc87b22dc60","type":"text","conversion_output":true,"text":"IE/3 days","text_display":" IE/3 days","confidence":1,"confidence_rate":1},{"cnt":[[150,1008],[1300,1008],[1300,1051],[150,1051]],"region":{"top_left_x":150,"top_left_y":1007,"width":1150,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89e1a5b44a7b4d7faae826e47bba45a4","type":"text","conversion_output":true,"text":"17) Diagnosis of and/or history of bladder pain or chronic pelvic pain","text_display":"\n17) Diagnosis of and/or history of bladder pain or chronic pelvic pain","confidence":1,"confidence_rate":1},{"cnt":[[150,1053],[1405,1053],[1405,1094],[150,1094]],"region":{"top_left_x":150,"top_left_y":1052,"width":1256,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aef99dddd53a4741b4c08206a544e63a","type":"text","conversion_output":true,"text":"18) Women who had intravesical Botox injection within the past 12 months","text_display":"\n18) Women who had intravesical Botox injection within the past 12 months","confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[150,1096],[1914,1096],[1914,1137],[150,1137]],"region":{"top_left_x":150,"top_left_y":1095,"width":1765,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66f9d043597a4feb9913c91c8dce6698","type":"text","conversion_output":true,"text":"19) Women who have undergone anterior or apical pelvic organ prolapse repair within the past 6 months","text_display":"\n19) Women who have undergone anterior or apical pelvic organ prolapse repair within the past 6 months","confidence":0.77734375,"confidence_rate":0.9976919097665813},{"cnt":[[211,1182],[1977,1182],[1977,1227],[211,1227]],"region":{"top_left_x":210,"top_left_y":1181,"width":1767,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb51a460798640418acb8d6bd1fcb832","type":"text","conversion_output":true,"text":"The team discussed the issue of whether bladder capacity should determine eligibility. Historically, some","text_display":"\n\nThe team discussed the issue of whether bladder capacity should determine eligibility. Historically, some","confidence":1,"confidence_rate":1},{"cnt":[[146,1227],[1880,1227],[1880,1270],[146,1270]],"region":{"top_left_x":146,"top_left_y":1226,"width":1734,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a8c6228d67c47ef84a834eb63a075e8","type":"text","conversion_output":true,"text":"clinicians have used bladder capacity as a criteria for whether a woman with MUI is eligible for an anti-","text_display":" clinicians have used bladder capacity as a criteria for whether a woman with MUI is eligible for an anti","confidence":1,"confidence_rate":1},{"cnt":[[146,1272],[1944,1272],[1944,1313],[146,1313]],"region":{"top_left_x":146,"top_left_y":1271,"width":1799,"height":42},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"812849c74f7d4ad3acfa8b432273c411","type":"text","conversion_output":true,"text":"incontinence procedure for SUI, often excluding women with capacities \\(<150-200 cc\\) to avoid exacerbation","text_display":"incontinence procedure for SUI, often excluding women with capacities \\(<150-200 cc\\) to avoid exacerbation","confidence":0.99755859375,"confidence_rate":0.9999783684521797},{"cnt":[[146,1315],[1914,1315],[1914,1356],[146,1356]],"region":{"top_left_x":146,"top_left_y":1314,"width":1769,"height":42},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9020c35ba1ee45ddb3952ad0a303a8cc","type":"text","conversion_output":true,"text":"of OAB symptoms. Upon review of the literature, there is very little evidence to support excluding women","text_display":" of OAB symptoms. Upon review of the literature, there is very little evidence to support excluding women","confidence":0.97265625,"confidence_rate":0.9997589460319615},{"cnt":[[146,1358],[1910,1358],[1910,1403],[146,1403]],"region":{"top_left_x":146,"top_left_y":1357,"width":1764,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a267d6657524e82b622e8a437f0b26c","type":"text","conversion_output":true,"text":"with a \"small\" bladder capacity, or to guide what volume defines a \"small\" capacity bladder. Gamble et al","text_display":" with a \"small\" bladder capacity, or to guide what volume defines a \"small\" capacity bladder. Gamble et al","confidence":1,"confidence_rate":1},{"cnt":[[146,1403],[1964,1403],[1964,1446],[146,1446]],"region":{"top_left_x":146,"top_left_y":1402,"width":1818,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f563371211214a0bb71be60594aad95f","type":"text","conversion_output":true,"text":"performed a retrospective study to evaluate predictors of persistent postoperative detrusor overactivity after","text_display":" performed a retrospective study to evaluate predictors of persistent postoperative detrusor overactivity after","confidence":0.9990234375,"confidence_rate":0.9999915040391533},{"cnt":[[146,1444],[1927,1444],[1927,1489],[146,1489]],"region":{"top_left_x":146,"top_left_y":1443,"width":1782,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a24ce51a797a42d5955c804d5223f9f6","type":"text","conversion_output":true,"text":"a variety of slings. \\({ }^{79}\\) They found that the mean maximum cystometric capacity was smaller in women with","text_display":" a variety of slings. \\({ }^{79}\\) They found that the mean maximum cystometric capacity was smaller in women with","confidence":1,"confidence_rate":1},{"cnt":[[146,1491],[1931,1491],[1931,1534],[146,1534]],"region":{"top_left_x":146,"top_left_y":1491,"width":1786,"height":43},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37aecad52b654745b59f19193b2d3b5b","type":"text","conversion_output":true,"text":"postoperative persistent DO compared to those with resolved DO. However, the mean capacity in women","text_display":" postoperative persistent DO compared to those with resolved DO. However, the mean capacity in women","confidence":1,"confidence_rate":1},{"cnt":[[146,1534],[1893,1534],[1893,1577],[146,1577]],"region":{"top_left_x":146,"top_left_y":1533,"width":1747,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"767df371372040578c2356f7b1361f2c","type":"text","conversion_output":true,"text":"with persistent DO was 459 cc (SD 185) versus 539 cc (SD 176), which does not support the traditional","text_display":" with persistent DO was 459 cc (SD 185) versus 539 cc (SD 176), which does not support the traditional","confidence":0.63330078125,"confidence_rate":0.9960697282816181},{"cnt":[[146,1577],[1820,1577],[1820,1622],[146,1622]],"region":{"top_left_x":146,"top_left_y":1576,"width":1674,"height":47},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25316d7eb35c4f1d901ca3dc9d2d676b","type":"text","conversion_output":true,"text":"teaching of avoiding slings in women with capacities less than \\(150-200 cc\\). Also, \\(37 \\%\\) of their study","text_display":" teaching of avoiding slings in women with capacities less than \\(150-200 cc\\). Also, \\(37 \\%\\) of their study","confidence":0.99365234375,"confidence_rate":0.9999436485941479},{"cnt":[[146,1624],[1940,1624],[1940,1665],[146,1665]],"region":{"top_left_x":146,"top_left_y":1624,"width":1795,"height":42},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dacda6ec6f649b791e9bdc81d053155","type":"text","conversion_output":true,"text":"population included traditional bladder neck slings, which may be more obstructive than MUS. Finally, the","text_display":" population included traditional bladder neck slings, which may be more obstructive than MUS. Finally, the","confidence":1,"confidence_rate":1},{"cnt":[[148,1667],[1869,1667],[1869,1708],[148,1708]],"region":{"top_left_x":148,"top_left_y":1667,"width":1722,"height":42},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e72973bb19254d32a6e8e8c3b08f039b","type":"text","conversion_output":true,"text":"proportion of women reporting UUI symptoms in this study was not different between women who had","text_display":" proportion of women reporting UUI symptoms in this study was not different between women who had","confidence":1,"confidence_rate":1},{"cnt":[[148,1710],[1901,1710],[1901,1755],[148,1755]],"region":{"top_left_x":148,"top_left_y":1710,"width":1754,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85b9feaf7145498aa230d0e54f0ae0a1","type":"text","conversion_output":true,"text":"resolved versus persistent DO, highlighting the limitation of using UDE parameters to predict symptoms.","text_display":" resolved versus persistent DO, highlighting the limitation of using UDE parameters to predict symptoms.","confidence":1,"confidence_rate":1},{"cnt":[[146,1753],[1927,1753],[1927,1798],[146,1798]],"region":{"top_left_x":146,"top_left_y":1753,"width":1782,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1bd0b4dafbe4ebca422503e330c5b1b","type":"text","conversion_output":true,"text":"Numerous other studies have failed to demonstrate any specific bladder capacity cutoff that is associated","text_display":" Numerous other studies have failed to demonstrate any specific bladder capacity cutoff that is associated","confidence":1,"confidence_rate":1},{"cnt":[[146,1796],[1222,1796],[1222,1841],[146,1841]],"region":{"top_left_x":146,"top_left_y":1796,"width":1077,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4187215ab1c94583ba27afd8df198a31","type":"text","conversion_output":true,"text":"with better or worse outcomes or poses a safety issue for MUS.","text_display":" with better or worse outcomes or poses a safety issue for MUS.","confidence":1,"confidence_rate":1},{"cnt":[[271,1841],[1897,1841],[1897,1884],[271,1884]],"region":{"top_left_x":270,"top_left_y":1841,"width":1628,"height":44},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf9b7b753d9e45e08c3d38b04b583ac5","type":"text","conversion_output":true,"text":"Because there is a lack of evidence to support setting a minimum bladder capacity cutoff for this","text_display":"\n\nBecause there is a lack of evidence to support setting a minimum bladder capacity cutoff for this","confidence":1,"confidence_rate":1},{"cnt":[[146,1886],[1895,1886],[1895,1927],[146,1927]],"region":{"top_left_x":146,"top_left_y":1886,"width":1749,"height":42},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae308a7a20dc472a8692f777c2bc7252","type":"text","conversion_output":true,"text":"study, women determined to be eligible for a MUS based on their clinician's judgment will be eligible for","text_display":" study, women determined to be eligible for a MUS based on their clinician's judgment will be eligible for","confidence":1,"confidence_rate":1},{"cnt":[[148,1929],[1927,1929],[1927,1972],[148,1972]],"region":{"top_left_x":148,"top_left_y":1929,"width":1780,"height":44},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5553c029a9c7451d860bc1e60850d49e","type":"text","conversion_output":true,"text":"ESTEEM, regardless of bladder capacity. One advantage of the ESTEEM design is that only women who","text_display":" ESTEEM, regardless of bladder capacity. One advantage of the ESTEEM design is that only women who","confidence":1,"confidence_rate":1},{"cnt":[[146,1972],[1893,1972],[1893,2017],[146,2017]],"region":{"top_left_x":146,"top_left_y":1972,"width":1747,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef8f1c3dfa9a4eeb9e38ba7eee734ba7","type":"text","conversion_output":true,"text":"have been offered a MUS by their clinician will be eligible. Therefore, if the provider determines that the","text_display":" have been offered a MUS by their clinician will be eligible. Therefore, if the provider determines that the","confidence":1,"confidence_rate":1},{"cnt":[[146,2017],[1858,2017],[1858,2060],[146,2060]],"region":{"top_left_x":146,"top_left_y":2017,"width":1713,"height":44},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a45720dc8cb47be97231d765bf93921","type":"text","conversion_output":true,"text":"patient is not clinically a candidate for a MUS, she will not be eligible. In addition, we will be excluding","text_display":" patient is not clinically a candidate for a MUS, she will not be eligible. In addition, we will be excluding","confidence":1,"confidence_rate":1},{"cnt":[[146,2062],[1927,2062],[1927,2103],[146,2103]],"region":{"top_left_x":146,"top_left_y":2062,"width":1782,"height":42},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5538bd56c974edaaadad6e448682c7a","type":"text","conversion_output":true,"text":"women with a history of painful bladder or chronic pelvic pain syndromes who often have \"small\" capacity","text_display":" women with a history of painful bladder or chronic pelvic pain syndromes who often have \"small\" capacity","confidence":1,"confidence_rate":1},{"cnt":[[146,2105],[1858,2105],[1858,2146],[146,2146]],"region":{"top_left_x":146,"top_left_y":2105,"width":1713,"height":42},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1b8219eac0a4dcebef51212cf229d83","type":"text","conversion_output":true,"text":"bladders. To further contribute to the literature about this issue, we will collect data on both maximum","text_display":" bladders. To further contribute to the literature about this issue, we will collect data on both maximum","confidence":1,"confidence_rate":1},{"cnt":[[146,2148],[1934,2148],[1934,2194],[146,2194]],"region":{"top_left_x":146,"top_left_y":2148,"width":1788,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d67392c24bb4865bd68c809cf9eabb5","type":"text","conversion_output":true,"text":"cystometric capacity on UDE and functional bladder capacity based on voiding diaries and evaluate these","text_display":" cystometric capacity on UDE and functional bladder capacity based on voiding diaries and evaluate these","confidence":1,"confidence_rate":1},{"cnt":[[146,2191],[1669,2191],[1669,2237],[146,2237]],"region":{"top_left_x":146,"top_left_y":2191,"width":1524,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5134596e8b58434d88ec2c6156d3d5b9","type":"text","conversion_output":true,"text":"variables as potential predictors of worsening OAB symptoms in our exploratory analyses.","text_display":" variables as potential predictors of worsening OAB symptoms in our exploratory analyses.","confidence":0.5830078125,"confidence_rate":0.9942151337922905},{"cnt":[[144,2320],[617,2320],[617,2368],[144,2368]],"region":{"top_left_x":143,"top_left_y":2320,"width":474,"height":48},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc3d95ff0f46441f9c4fca57986dc11d","type":"section_header","conversion_output":false,"children_ids":["67eb211bdda54b89b5ba8a66f295101b"],"text":"","text_display":""},{"cnt":[[146,2325],[614,2325],[614,2365],[146,2365]],"region":{"top_left_x":146,"top_left_y":2324,"width":469,"height":42},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67eb211bdda54b89b5ba8a66f295101b","type":"text","conversion_output":true,"parent_id":"fc3d95ff0f46441f9c4fca57986dc11d","text":"4.4. Screening for Eligibility","text_display":"\n\n\\subsection*{4.4. Screening for Eligibility}","confidence":0.99951171875,"confidence_rate":0.9999860457974148},{"cnt":[[271,2376],[1927,2376],[1927,2419],[271,2419]],"region":{"top_left_x":270,"top_left_y":2376,"width":1658,"height":44},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"298686d222224c19aec0df75d8604bf9","type":"text","conversion_output":true,"text":"It is anticipated that participants will come from PFDN Clinical Site practices. Women with MUI will","text_display":"\n\nIt is anticipated that participants will come from PFDN Clinical Site practices. Women with MUI will","confidence":1,"confidence_rate":1},{"cnt":[[146,2419],[1777,2419],[1777,2464],[146,2464]],"region":{"top_left_x":146,"top_left_y":2419,"width":1631,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf6a696c242846ee92c86aff19033903","type":"text","conversion_output":true,"text":"be offered the full range of treatment options consistent with routine practice including expectant","text_display":" be offered the full range of treatment options consistent with routine practice including expectant","confidence":1,"confidence_rate":1},{"cnt":[[146,2464],[1880,2464],[1880,2507],[146,2507]],"region":{"top_left_x":146,"top_left_y":2464,"width":1734,"height":44},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d0dadf405e34b98b268abb9bc0ee3c2","type":"text","conversion_output":true,"text":"management, pelvic floor muscle therapy, behavioral therapy, medication and possibly surgery. Those","text_display":" management, pelvic floor muscle therapy, behavioral therapy, medication and possibly surgery. Those","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f2a489a82774d219a085a560a17399b","type":"page_info","conversion_output":false,"text":"28","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aba5ebdefc3c4e5588ce76fd1df117bf","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-29","page":29,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcc613bfad8d42ec8d0e654eb906b75b","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4543906cac14acaacacf746c5f4c696","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3474c4fee8634cab8fa3f56f8ee4f06a","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a955133d49d4b0cb3a85cb0735ab039","type":"text","conversion_output":true,"text":"Confidential","text_display":"\n\nConfidential","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1916,260],[1916,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1771,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65c94d3de60744ceb394c82903cdb9bf","type":"text","conversion_output":true,"text":"patients who are offered surgery by their physician and who elect to undergo MUS for SUI will be offered","text_display":"\npatients who are offered surgery by their physician and who elect to undergo MUS for SUI will be offered","confidence":1,"confidence_rate":1},{"cnt":[[148,305],[1944,305],[1944,346],[148,346]],"region":{"top_left_x":148,"top_left_y":305,"width":1797,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6b1dd3aaeb74bccad936dbe6816b3df","type":"text","conversion_output":true,"text":"participation in ESTEEM. Subjects will be identified as ESTEEM candidates by their physician. Because in","text_display":" participation in ESTEEM. Subjects will be identified as ESTEEM candidates by their physician. Because in","confidence":1,"confidence_rate":1},{"cnt":[[148,348],[1949,348],[1949,391],[148,391]],"region":{"top_left_x":148,"top_left_y":348,"width":1801,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e8b2228bf2b471c84df75b3cf001891","type":"text","conversion_output":true,"text":"ESTEEM, women must have elected to undergo MUS, it does not compete with the current ongoing PFDN","text_display":" ESTEEM, women must have elected to undergo MUS, it does not compete with the current ongoing PFDN","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1592,391],[1592,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1446,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3cb8879403244e5b0f423fa689a7302","type":"text","conversion_output":true,"text":"trial, ROSETTA, in which women desiring a MUS are actually excluded from that trial.","text_display":" trial, ROSETTA, in which women desiring a MUS are actually excluded from that trial.","confidence":1,"confidence_rate":1},{"cnt":[[271,434],[1949,434],[1949,479],[271,479]],"region":{"top_left_x":270,"top_left_y":433,"width":1679,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bc644f1c13249d0bc44c131f664bcfb","type":"text","conversion_output":true,"text":"Subjects will be approached by study personnel consistent with local IRB requirements. Enrollment","text_display":"\n\nSubjects will be approached by study personnel consistent with local IRB requirements. Enrollment","confidence":1,"confidence_rate":1},{"cnt":[[146,477],[1927,477],[1927,522],[146,522]],"region":{"top_left_x":146,"top_left_y":476,"width":1782,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4eecbf4656f44ae8a0e540a3f6dd5fa8","type":"text","conversion_output":true,"text":"will occur after written and verbal consent. If the participant accepts participation in ESTEEM, the UDI will","text_display":" will occur after written and verbal consent. If the participant accepts participation in ESTEEM, the UDI will","confidence":1,"confidence_rate":1},{"cnt":[[146,524],[1962,524],[1962,563],[146,563]],"region":{"top_left_x":146,"top_left_y":524,"width":1816,"height":39},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdeaa8a8f3054b4b9e98d14fe039d3f3","type":"text","conversion_output":true,"text":"be administered to confirm at least moderate bother from both SUI and UUI and the coordinator will confirm","text_display":" be administered to confirm at least moderate bother from both SUI and UUI and the coordinator will confirm","confidence":1,"confidence_rate":1},{"cnt":[[146,567],[1884,567],[1884,610],[146,610]],"region":{"top_left_x":146,"top_left_y":567,"width":1739,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2aac58ebc448444d88e771d3f186d6e7","type":"text","conversion_output":true,"text":"documentation of SUI by either CST or UDE within the past 18 months, and UI symptoms for at least 3","text_display":" documentation of SUI by either CST or UDE within the past 18 months, and UI symptoms for at least 3","confidence":1,"confidence_rate":1},{"cnt":[[146,610],[1966,610],[1966,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1820,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afa73999fdcf4baea8403724705babb7","type":"text","conversion_output":true,"text":"months. The coordinator will also document that the patient understands that behavioral/pelvic floor therapy","text_display":" months. The coordinator will also document that the patient understands that behavioral/pelvic floor therapy","confidence":1,"confidence_rate":1},{"cnt":[[146,653],[1921,653],[1921,698],[146,698]],"region":{"top_left_x":146,"top_left_y":653,"width":1775,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a64402be10df4ccfa647733bf543bd57","type":"text","conversion_output":true,"text":"is a treatment option for MUI outside of ESTEEM (See section 5.3, \"What is the best control group\"). She","text_display":" is a treatment option for MUI outside of ESTEEM (See section 5.3, \"What is the best control group\"). She","confidence":1,"confidence_rate":1},{"cnt":[[146,698],[1074,698],[1074,741],[146,741]],"region":{"top_left_x":146,"top_left_y":698,"width":929,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8edcac41df174c138f1f4babc6e02e0b","type":"text","conversion_output":true,"text":"will be instructed on how to complete the voiding diary.","text_display":" will be instructed on how to complete the voiding diary.","confidence":1,"confidence_rate":1},{"cnt":[[271,743],[1966,743],[1966,786],[271,786]],"region":{"top_left_x":270,"top_left_y":743,"width":1696,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a830970d596486e8eb09392a5a3be47","type":"text","conversion_output":true,"text":"To address the issue of overactive bladder medication use, these subjects will be required to have a","text_display":"\n\nTo address the issue of overactive bladder medication use, these subjects will be required to have a","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[146,786],[1863,786],[1863,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1717,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40d4b502e3f0474e83e3f56b2fe784d9","type":"text","conversion_output":true,"text":"washout of 3 weeks prior to completing the voiding diary. The anticholinergic with the longest half-life","text_display":" washout of 3 weeks prior to completing the voiding diary. The anticholinergic with the longest half-life","confidence":1,"confidence_rate":1},{"cnt":[[146,829],[1893,829],[1893,874],[146,874]],"region":{"top_left_x":146,"top_left_y":829,"width":1747,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2be4840a8a07436f8cff0385c71ad39a","type":"text","conversion_output":true,"text":"currently on the market is Vesicare with a half life of \\(45-68\\) hours. Therefore, by 1 week there should be","text_display":" currently on the market is Vesicare with a half life of \\(45-68\\) hours. Therefore, by 1 week there should be","confidence":0.9619140625,"confidence_rate":0.9996653132233314},{"cnt":[[146,872],[1893,872],[1893,917],[146,917]],"region":{"top_left_x":146,"top_left_y":872,"width":1747,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fbef2f5e8d04c57a887db26dc287377","type":"text","conversion_output":true,"text":"negligible amounts in the bloodstream and by 2 weeks the drug would be completely out of the system.","text_display":" negligible amounts in the bloodstream and by 2 weeks the drug would be completely out of the system.","confidence":1,"confidence_rate":1},{"cnt":[[146,920],[1962,920],[1962,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1816,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af95a3364c4b4fdbbcc75a431ddd356e","type":"text","conversion_output":true,"text":"Therefore, 3 weeks should be adequate time for washout and this time period is consistent with prior PFDN","text_display":" Therefore, 3 weeks should be adequate time for washout and this time period is consistent with prior PFDN","confidence":1,"confidence_rate":1},{"cnt":[[146,960],[1953,960],[1953,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":960,"width":1807,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8db50e536994044812ed776d2826012","type":"text","conversion_output":true,"text":"studies (ABC trial \\({ }^{78}\\) ). In addition, because we are highly interested in what happens to OAB outcomes after","text_display":" studies (ABC trial \\({ }^{78}\\) ). In addition, because we are highly interested in what happens to OAB outcomes after","confidence":0.9946362947812304,"confidence_rate":0.9999562762280245},{"cnt":[[146,1005],[1970,1005],[1970,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1005,"width":1825,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"857dab8879f847c595f5560193e4c35e","type":"text","conversion_output":true,"text":"MUS, subjects will need to remain off of overactive bladder medication until 3 months postoperative to allow","text_display":" MUS, subjects will need to remain off of overactive bladder medication until 3 months postoperative to allow","confidence":0.998046875,"confidence_rate":0.9999831463934391},{"cnt":[[146,1051],[1944,1051],[1944,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1050,"width":1799,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ab685a962d04deeb47a2c31b366f3c7","type":"text","conversion_output":true,"text":"accurate assessment of these symptoms postoperatively (See statistical analysis plan for details on why 3","text_display":" accurate assessment of these symptoms postoperatively (See statistical analysis plan for details on why 3","confidence":1,"confidence_rate":1},{"cnt":[[146,1094],[1979,1094],[1979,1139],[146,1139]],"region":{"top_left_x":146,"top_left_y":1093,"width":1833,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b73b37a3735e42968ef8490470ea35a3","type":"text","conversion_output":true,"text":"months is adequate to allow analyses). Subjects who re-start overactive bladder medication postoperatively","text_display":" months is adequate to allow analyses). Subjects who re-start overactive bladder medication postoperatively","confidence":1,"confidence_rate":1},{"cnt":[[146,1139],[1863,1139],[1863,1182],[146,1182]],"region":{"top_left_x":146,"top_left_y":1138,"width":1717,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afd25bcfb3fb4361bbfca83c3e6be222","type":"text","conversion_output":true,"text":"will be considered as having \"additional treatment\". Every effort will be made to schedule the patient's","text_display":" will be considered as having \"additional treatment\". Every effort will be made to schedule the patient's","confidence":1,"confidence_rate":1},{"cnt":[[146,1182],[1680,1182],[1680,1227],[146,1227]],"region":{"top_left_x":146,"top_left_y":1181,"width":1535,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dae3a41d83d748008cdd41c31e760308","type":"text","conversion_output":true,"text":"surgery within 3 months from enrollment (see Section 4.6, Appointment scheduling below).","text_display":" surgery within 3 months from enrollment (see Section 4.6, Appointment scheduling below).","confidence":1,"confidence_rate":1},{"cnt":[[142,1268],[462,1268],[462,1313],[142,1313]],"region":{"top_left_x":141,"top_left_y":1267,"width":321,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc3340572e5e4aa8b9350b0a5fe2dc5e","type":"section_header","conversion_output":false,"children_ids":["0f935be306b44818be0297bb8e6c2f7a"],"text":"","text_display":""},{"cnt":[[146,1268],[458,1268],[458,1311],[146,1311]],"region":{"top_left_x":146,"top_left_y":1267,"width":312,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f935be306b44818be0297bb8e6c2f7a","type":"text","conversion_output":true,"parent_id":"dc3340572e5e4aa8b9350b0a5fe2dc5e","text":"4.5. Baseline Visit","text_display":"\n\n\\subsection*{4.5. Baseline Visit}","confidence":1,"confidence_rate":1},{"cnt":[[271,1315],[1790,1315],[1790,1358],[271,1358]],"region":{"top_left_x":270,"top_left_y":1314,"width":1520,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3931688a7cd549faa540c207e842d930","type":"text","conversion_output":true,"text":"At the baseline visit, the voiding diary will be reviewed to ensure that entries are clear and","text_display":"\n\nAt the baseline visit, the voiding diary will be reviewed to ensure that entries are clear and","confidence":1,"confidence_rate":1},{"cnt":[[146,1358],[1854,1358],[1854,1403],[146,1403]],"region":{"top_left_x":146,"top_left_y":1357,"width":1709,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b28a8d87de7435da23a09c2306c2430","type":"text","conversion_output":true,"text":"interpretable. If the first baseline voiding diary is not acceptable, the subject will be allowed one more","text_display":" interpretable. If the first baseline voiding diary is not acceptable, the subject will be allowed one more","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[146,1401],[1910,1401],[1910,1446],[146,1446]],"region":{"top_left_x":146,"top_left_y":1400,"width":1764,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d6fe47211ce4f528a80c73436cd13aa","type":"text","conversion_output":true,"text":"attempt. If the second baseline voiding diary is not acceptable, the subject will not be eligible for the trial.","text_display":" attempt. If the second baseline voiding diary is not acceptable, the subject will not be eligible for the trial.","confidence":1,"confidence_rate":1},{"cnt":[[271,1444],[1635,1444],[1635,1489],[271,1489]],"region":{"top_left_x":270,"top_left_y":1443,"width":1365,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36198e424f764023899e3b3adfb31f70","type":"text","conversion_output":true,"text":"Once eligibility is confirmed, pre-treatment information will be obtained including:","text_display":"\n\nOnce eligibility is confirmed, pre-treatment information will be obtained including:","confidence":1,"confidence_rate":1},{"cnt":[[348,1491],[1304,1491],[1304,1536],[348,1536]],"region":{"top_left_x":348,"top_left_y":1491,"width":957,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"499373ddd30b4299bb62b6c2e456f665","type":"text","conversion_output":true,"text":"- Demographics - age, race/ethnicity, education level","text_display":"\n- Demographics - age, race/ethnicity, education level","confidence":1,"confidence_rate":1},{"cnt":[[348,1538],[1828,1538],[1828,1583],[348,1583]],"region":{"top_left_x":348,"top_left_y":1538,"width":1481,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74a04f06880e4e51a36e6da87364de13","type":"text","conversion_output":true,"text":"- Medical history - prior urinary incontinence procedures and treatments, prior pelvic","text_display":"\n- Medical history - prior urinary incontinence procedures and treatments, prior pelvic","confidence":1,"confidence_rate":1},{"cnt":[[421,1583],[1222,1583],[1222,1626],[421,1626]],"region":{"top_left_x":421,"top_left_y":1583,"width":802,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d16e0bfb3834f528011e25b68e9c085","type":"text","conversion_output":true,"text":"surgeries, comorbidities, smoking, medications","text_display":" surgeries, comorbidities, smoking, medications","confidence":1,"confidence_rate":1},{"cnt":[[348,1629],[1876,1629],[1876,1674],[348,1674]],"region":{"top_left_x":348,"top_left_y":1628,"width":1528,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41589b3348f54dc7a2b5e6e314654a25","type":"text","conversion_output":true,"text":"- Physical exam - Body mass index, pelvic organ prolapse quantification (POPQ), PFM","text_display":"\n- Physical exam - Body mass index, pelvic organ prolapse quantification (POPQ), PFM","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[421,1671],[1089,1671],[1089,1717],[421,1717]],"region":{"top_left_x":421,"top_left_y":1671,"width":669,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cba6c14dbdb64348a7ecbb6b417a6659","type":"text","conversion_output":true,"text":"strength (Peritron and Brink measures)","text_display":" strength (Peritron and Brink measures)","confidence":1,"confidence_rate":1},{"cnt":[[348,1719],[1018,1719],[1018,1760],[348,1760]],"region":{"top_left_x":348,"top_left_y":1718,"width":671,"height":42},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43ab03a4189e4b559c2e00f2f66dfe2d","type":"text","conversion_output":true,"text":"- Questionnaires - self-administered","text_display":"\n- Questionnaires - self-administered","confidence":1,"confidence_rate":1},{"cnt":[[142,1805],[965,1805],[965,1854],[142,1854]],"region":{"top_left_x":141,"top_left_y":1804,"width":824,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"743835db8759467f8b6365cf5f0c2d12","type":"section_header","conversion_output":false,"children_ids":["389504cf9c5d46df98b40196ae44ae33"],"text":"","text_display":""},{"cnt":[[146,1809],[960,1809],[960,1850],[146,1850]],"region":{"top_left_x":146,"top_left_y":1808,"width":815,"height":42},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"389504cf9c5d46df98b40196ae44ae33","type":"text","conversion_output":true,"parent_id":"743835db8759467f8b6365cf5f0c2d12","text":"4.6. Appointment scheduling and randomization","text_display":"\n\n\\subsection*{4.6. Appointment scheduling and randomization}","confidence":1,"confidence_rate":1},{"cnt":[[271,1852],[1871,1852],[1871,1897],[271,1897]],"region":{"top_left_x":270,"top_left_y":1851,"width":1602,"height":47},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad3e31917c6741f685d4526eabeb6e99","type":"text","conversion_output":true,"text":"Once patients are enrolled, surgery should be scheduled within 3 months from enrollment, and","text_display":"\n\nOnce patients are enrolled, surgery should be scheduled within 3 months from enrollment, and","confidence":1,"confidence_rate":1},{"cnt":[[146,1895],[1886,1895],[1886,1940],[146,1940]],"region":{"top_left_x":146,"top_left_y":1894,"width":1741,"height":47},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0640283ddfb745c984eca2700f8b3199","type":"text","conversion_output":true,"text":"randomization should occur 7-35 days prior to the booked surgical date. This will allow enough time for","text_display":" randomization should occur 7-35 days prior to the booked surgical date. This will allow enough time for","confidence":0.9443359375,"confidence_rate":0.9994698321613819},{"cnt":[[146,1938],[1910,1938],[1910,1983],[146,1983]],"region":{"top_left_x":146,"top_left_y":1937,"width":1764,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa979b0061184baa97d56fb92f415ee5","type":"text","conversion_output":true,"text":"those subjects randomized to the BPTx intervention to have their first preoperative visit scheduled, while","text_display":" those subjects randomized to the BPTx intervention to have their first preoperative visit scheduled, while","confidence":1,"confidence_rate":1},{"cnt":[[146,1983],[1953,1983],[1953,2026],[146,2026]],"region":{"top_left_x":146,"top_left_y":1983,"width":1807,"height":43},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ad88e8124ba4449b68a3d441615f688","type":"text","conversion_output":true,"text":"minimizing withdrawal from the study due to unforeseen personal circumstances that may require a patient","text_display":" minimizing withdrawal from the study due to unforeseen personal circumstances that may require a patient","confidence":1,"confidence_rate":1},{"cnt":[[146,2026],[1869,2026],[1869,2071],[146,2071]],"region":{"top_left_x":146,"top_left_y":2025,"width":1724,"height":47},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f445d03e4fd24eac8262b99e8ab0aa07","type":"text","conversion_output":true,"text":"to cancel or change the date of their surgical procedure. Surgery should be performed 7-35 days after","text_display":" to cancel or change the date of their surgical procedure. Surgery should be performed 7-35 days after","confidence":0.63671875,"confidence_rate":0.9957503080239233},{"cnt":[[146,2071],[1824,2071],[1824,2116],[146,2116]],"region":{"top_left_x":146,"top_left_y":2071,"width":1679,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52eb2ef185f34aa192d72b88066c0efd","type":"text","conversion_output":true,"text":"randomization and the surgery should be scheduled before randomization occurs. If a participant is","text_display":" randomization and the surgery should be scheduled before randomization occurs. If a participant is","confidence":1,"confidence_rate":1},{"cnt":[[146,2114],[1897,2114],[1897,2159],[146,2159]],"region":{"top_left_x":146,"top_left_y":2114,"width":1752,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7123212f680429fba09708bc1d82855","type":"text","conversion_output":true,"text":"randomized but does not undergo surgery, the planned surgery date will serve as Time 0 for calculating","text_display":" randomized but does not undergo surgery, the planned surgery date will serve as Time 0 for calculating","confidence":1,"confidence_rate":1},{"cnt":[[146,2157],[1884,2157],[1884,2202],[146,2202]],"region":{"top_left_x":146,"top_left_y":2157,"width":1739,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"720a3de33029425082f0fd162d733600","type":"text","conversion_output":true,"text":"windows for follow up visits and phone calls. If surgery is rescheduled but does not occur, then the last","text_display":" windows for follow up visits and phone calls. If surgery is rescheduled but does not occur, then the last","confidence":1,"confidence_rate":1},{"cnt":[[146,2202],[1878,2202],[1878,2245],[146,2245]],"region":{"top_left_x":146,"top_left_y":2202,"width":1732,"height":44},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc812f219dd44ecdbff14787dff55005","type":"text","conversion_output":true,"text":"planned date of surgery will be Time 0 . If the participant decides against surgery but later changes her","text_display":" planned date of surgery will be Time 0 . If the participant decides against surgery but later changes her","confidence":0.9580078125,"confidence_rate":0.9996204318238435},{"cnt":[[146,2245],[1979,2245],[1979,2292],[146,2292]],"region":{"top_left_x":146,"top_left_y":2245,"width":1833,"height":48},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"764165a3a593486e9ecb8be1c0407d13","type":"text","conversion_output":true,"text":"mind, the planned date of the surgery that did not occur will be Time 0 , and the surgery that occurs after she","text_display":" mind, the planned date of the surgery that did not occur will be Time 0 , and the surgery that occurs after she","confidence":0.994636058807373,"confidence_rate":0.9999548045610374},{"cnt":[[146,2290],[1124,2290],[1124,2335],[146,2335]],"region":{"top_left_x":146,"top_left_y":2290,"width":978,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64602382c8c44ea79f1c5a98213727bf","type":"text","conversion_output":true,"text":"changes her mind will be considered additional treatment.","text_display":" changes her mind will be considered additional treatment.","confidence":1,"confidence_rate":1},{"cnt":[[271,2333],[1962,2333],[1962,2378],[271,2378]],"region":{"top_left_x":270,"top_left_y":2333,"width":1692,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3402701102024184a2cd18eb9b7be5e1","type":"text","conversion_output":true,"text":"Postoperatively, all subjects will return for visits at 2 and 8 weeks and 3,6 , and 12 months. Subjects","text_display":"\n\nPostoperatively, all subjects will return for visits at 2 and 8 weeks and 3,6 , and 12 months. Subjects","confidence":0.9970724582672119,"confidence_rate":0.999975568337083},{"cnt":[[146,2376],[1949,2376],[1949,2421],[146,2421]],"region":{"top_left_x":146,"top_left_y":2376,"width":1803,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25fb46889db14bd3933a235b3da35efe","type":"text","conversion_output":true,"text":"randomized to BPTx will undergo undergo BPTx intervention sessions at 2 weeks preoperatively, and then","text_display":" randomized to BPTx will undergo undergo BPTx intervention sessions at 2 weeks preoperatively, and then","confidence":1,"confidence_rate":1},{"cnt":[[146,2419],[1951,2419],[1951,2464],[146,2464]],"region":{"top_left_x":146,"top_left_y":2419,"width":1805,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c18aa028e07a419da07aa1ab59508655","type":"text","conversion_output":true,"text":"postoperatively at \\(2,4,6,8\\) weeks and 6 months. All subjects (intervention and control) will have visits with","text_display":" postoperatively at \\(2,4,6,8\\) weeks and 6 months. All subjects (intervention and control) will have visits with","confidence":0.99853515625,"confidence_rate":0.9999876814398867},{"cnt":[[146,2464],[1966,2464],[1966,2507],[146,2507]],"region":{"top_left_x":146,"top_left_y":2464,"width":1820,"height":44},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa28dbe5b7c94ffa93a2a5cb83c70f92","type":"text","conversion_output":true,"text":"a masked assessor for PFM Peritron measurements at baseline, and 2 weeks and 8 weeks, and 12 months","text_display":" a masked assessor for PFM Peritron measurements at baseline, and 2 weeks and 8 weeks, and 12 months","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c782ddba13e4a0ca467b5c8274c810c","type":"page_info","conversion_output":false,"text":"29","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04a1ec41ee0e44879ca9d0fdc69d21b9","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-30","page":30,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa3e8b67d12146188a5f6965a9e3928d","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb60406b9e014c378e730b7d8b52defa","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d39848a6431349e5b79da5b73b0bff53","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc80e6aeceec47caadcbc717381b9e2f","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1927,260],[1927,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1782,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef535417a53f427186ebddc26371b10d","type":"page_info","conversion_output":false,"text":"postoperative. (See Assessment Table 11). All subjects will receive calls from research staff to determine","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1149,305],[1149,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1004,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25bd62dcc36a4273a1a01ff5b58cca47","type":"page_info","conversion_output":false,"text":"AEs and additional treatment 4 and 6 weeks postoperative.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[144,387],[982,387],[982,432],[144,432]],"region":{"top_left_x":143,"top_left_y":386,"width":839,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3212dfac93d947a5bdcd2f6c46767f22","type":"section_header","conversion_output":false,"children_ids":["ef20d0bdcc5540d8afae2ba3274fae87"],"text":"","text_display":""},{"cnt":[[146,391],[982,391],[982,428],[146,428]],"region":{"top_left_x":146,"top_left_y":391,"width":836,"height":37},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef20d0bdcc5540d8afae2ba3274fae87","type":"text","conversion_output":true,"parent_id":"3212dfac93d947a5bdcd2f6c46767f22","text":"5. DESCRIPTION OF STUDY INTERVENTIONS","text_display":"\n\n\\section*{5. DESCRIPTION OF STUDY INTERVENTIONS}","confidence":1,"confidence_rate":1},{"cnt":[[144,473],[930,473],[930,522],[144,522]],"region":{"top_left_x":143,"top_left_y":472,"width":788,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ec09c0f6dfb42179fb6f4e3fcfbdfec","type":"section_header","conversion_output":false,"children_ids":["ff5c0ba7ec9140af8bc818aea49b9338"],"text":"","text_display":""},{"cnt":[[146,477],[930,477],[930,518],[146,518]],"region":{"top_left_x":146,"top_left_y":476,"width":785,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff5c0ba7ec9140af8bc818aea49b9338","type":"text","conversion_output":true,"parent_id":"7ec09c0f6dfb42179fb6f4e3fcfbdfec","text":"5.1. Midurethral sling procedure (both groups)","text_display":"\n\n\\subsection*{5.1. Midurethral sling procedure (both groups)}","confidence":1,"confidence_rate":1},{"cnt":[[271,529],[1910,529],[1910,574],[271,574]],"region":{"top_left_x":270,"top_left_y":528,"width":1640,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54e454dd5ca443c3bbad4897652efb4e","type":"text","conversion_output":true,"text":"To address the potential issue that different sling or mesh types may result in different outcomes,","text_display":"\n\nTo address the potential issue that different sling or mesh types may result in different outcomes,","confidence":1,"confidence_rate":1},{"cnt":[[146,571],[1949,571],[1949,617],[146,617]],"region":{"top_left_x":146,"top_left_y":571,"width":1803,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdfebec19050428eac01094ad85c04e8","type":"text","conversion_output":true,"text":"MUS types will be standardized. All women (both groups) will receive a MUS which can include the TVT \\({ }^{\\text {TM }}\\)","text_display":" MUS types will be standardized. All women (both groups) will receive a MUS which can include the TVT \\({ }^{\\text {TM }}\\)","confidence":0.9810807003777882,"confidence_rate":0.999839503978191},{"cnt":[[146,614],[1906,614],[1906,660],[146,660]],"region":{"top_left_x":146,"top_left_y":614,"width":1760,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"451a7ac2be8645a286ee856d8c3fe4b6","type":"text","conversion_output":true,"text":"(mechanical cut mesh only, Gynecare, ETHICON Women's Health \\& Urology, Somerville, NJ), TVT-O \\({ }^{\\text {TM }}\\)","text_display":" (mechanical cut mesh only, Gynecare, ETHICON Women's Health \\& Urology, Somerville, NJ), TVT-O \\({ }^{\\text {TM }}\\)","confidence":0.9652030700817704,"confidence_rate":0.9996838288813432},{"cnt":[[146,660],[1949,660],[1949,707],[146,707]],"region":{"top_left_x":146,"top_left_y":659,"width":1803,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92d10b2a8ab64350876660afa7143312","type":"text","conversion_output":true,"text":"(mechanical cut mesh only, Gynecare), or Monarc \\({ }^{\\text {TM }}\\) (American Medical Systems, Minnetonka, MN). In the","text_display":" (mechanical cut mesh only, Gynecare), or Monarc \\({ }^{\\text {TM }}\\) (American Medical Systems, Minnetonka, MN). In the","confidence":0.587225018596655,"confidence_rate":0.9956101002992342},{"cnt":[[146,705],[1931,705],[1931,750],[146,750]],"region":{"top_left_x":146,"top_left_y":704,"width":1786,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49295e0bf9ed42928926093826385772","type":"text","conversion_output":true,"text":"TOMUS trial and Barber's equivalence trial, these approaches and devices demonstrated equivalence for","text_display":" TOMUS trial and Barber's equivalence trial, these approaches and devices demonstrated equivalence for","confidence":1,"confidence_rate":1},{"cnt":[[146,748],[1906,748],[1906,793],[146,793]],"region":{"top_left_x":146,"top_left_y":747,"width":1760,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca16cef21737413692d65b46a0b47ca0","type":"text","conversion_output":true,"text":"improving objective success of SUI and were not significantly different for subjective success, persistent","text_display":" improving objective success of SUI and were not significantly different for subjective success, persistent","confidence":1,"confidence_rate":1},{"cnt":[[146,791],[1899,791],[1899,836],[146,836]],"region":{"top_left_x":146,"top_left_y":790,"width":1754,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82ddc89b451543c8880f47dcaa8be418","type":"text","conversion_output":true,"text":"UUI or de novo UUI. \\({ }^{24,31}\\) The Gynecare \"laser-cut\" slings will not be allowed in this trial due to data from","text_display":" UUI or de novo UUI. \\({ }^{24,31}\\) The Gynecare \"laser-cut\" slings will not be allowed in this trial due to data from","confidence":0.98486328125,"confidence_rate":0.9998760040441894},{"cnt":[[146,836],[1931,836],[1931,881],[146,881]],"region":{"top_left_x":146,"top_left_y":835,"width":1786,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1323ffa42dff48c08b731daa9f6b5d12","type":"text","conversion_output":true,"text":"Moalli et al showing that the laser-cut meshes are \"stiffer\" (less deformation under an applied load), which","text_display":" Moalli et al showing that the laser-cut meshes are \"stiffer\" (less deformation under an applied load), which","confidence":1,"confidence_rate":1},{"cnt":[[146,879],[1946,879],[1946,926],[146,926]],"region":{"top_left_x":146,"top_left_y":878,"width":1801,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"713b61b1ca124e1f8d1ba2ffb9b433e8","type":"text","conversion_output":true,"text":"theoretically may increase risk of mesh complications. \\({ }^{80}\\) Although it is unclear how \"laser-cut\" meshes may","text_display":" theoretically may increase risk of mesh complications. \\({ }^{80}\\) Although it is unclear how \"laser-cut\" meshes may","confidence":0.99853515625,"confidence_rate":0.9999879843534795},{"cnt":[[146,924],[1888,924],[1888,969],[146,969]],"region":{"top_left_x":146,"top_left_y":923,"width":1743,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbb0b85fdad848928e1e6cc25f00fe6a","type":"text","conversion_output":true,"text":"affect clinical outcomes, these types of slings were not included in the TOMUS or Barber's equivalence","text_display":" affect clinical outcomes, these types of slings were not included in the TOMUS or Barber's equivalence","confidence":1,"confidence_rate":1},{"cnt":[[146,967],[1923,967],[1923,1012],[146,1012]],"region":{"top_left_x":146,"top_left_y":966,"width":1777,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17d57d7696e64d22b9054f3e943bd498","type":"text","conversion_output":true,"text":"trials resulting in less published, long-term outcome data. \"Mini-sling\" or \"single-incision\" slings will not be","text_display":" trials resulting in less published, long-term outcome data. \"Mini-sling\" or \"single-incision\" slings will not be","confidence":1,"confidence_rate":1},{"cnt":[[146,1010],[1618,1010],[1618,1055],[146,1055]],"region":{"top_left_x":146,"top_left_y":1009,"width":1472,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3516a7a62e1f4347a570602cca1d300b","type":"text","conversion_output":true,"text":"allowed. Key aspects of the procedure will be standardized across surgeons and sites.","text_display":" allowed. Key aspects of the procedure will be standardized across surgeons and sites.","confidence":1,"confidence_rate":1},{"cnt":[[146,1100],[1858,1100],[1858,1145],[146,1145]],"region":{"top_left_x":146,"top_left_y":1100,"width":1713,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85a19297621449519d5379869ca45f46","type":"text","conversion_output":true,"text":"5.1.a. Surgeon Certification- To address the issue of surgeon certification and to ensure standardized","text_display":"\n5.1.a. Surgeon Certification- To address the issue of surgeon certification and to ensure standardized","confidence":0.99267578125,"confidence_rate":0.9999312998129468},{"cnt":[[146,1143],[1914,1143],[1914,1188],[146,1188]],"region":{"top_left_x":146,"top_left_y":1142,"width":1769,"height":47},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"802f687f3a564f9f942404e7c957da5b","type":"text","conversion_output":true,"text":"training of all surgeons, all \"certified surgeons\" will have performed a minimum of 20 midurethral sings of","text_display":" training of all surgeons, all \"certified surgeons\" will have performed a minimum of 20 midurethral sings of","confidence":1,"confidence_rate":1},{"cnt":[[146,1188],[1910,1188],[1910,1231],[146,1231]],"region":{"top_left_x":146,"top_left_y":1188,"width":1764,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cac02287bd824be29ba95813faef6e2e","type":"text","conversion_output":true,"text":"any type, including 5 of the specific MUS allowed in ESTEEM that the surgeon will be using in the study.","text_display":" any type, including 5 of the specific MUS allowed in ESTEEM that the surgeon will be using in the study.","confidence":1,"confidence_rate":1},{"cnt":[[146,1231],[1437,1231],[1437,1274],[146,1274]],"region":{"top_left_x":146,"top_left_y":1231,"width":1292,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2080fe6443ee43c292f6e2cf5750d43c","type":"text","conversion_output":true,"text":"The site PI must sign off that each participating surgeon has met the criteria.","text_display":" The site PI must sign off that each participating surgeon has met the criteria.","confidence":0.36638099793344736,"confidence_rate":0.9889055413111254},{"cnt":[[142,1315],[870,1315],[870,1364],[142,1364]],"region":{"top_left_x":141,"top_left_y":1314,"width":730,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11cbcb5c9d6042679d92bdc8e65fd3a9","type":"section_header","conversion_output":false,"children_ids":["2e0d224723524da7b3d8cf24639bc226"],"text":"","text_display":""},{"cnt":[[146,1319],[866,1319],[866,1360],[146,1360]],"region":{"top_left_x":146,"top_left_y":1319,"width":720,"height":41},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e0d224723524da7b3d8cf24639bc226","type":"text","conversion_output":true,"parent_id":"11cbcb5c9d6042679d92bdc8e65fd3a9","text":"5.1.b. Standardization of sling procedures:","text_display":"\n\n\\section*{5.1.b. Standardization of sling procedures:}","confidence":1,"confidence_rate":1},{"cnt":[[271,1362],[1914,1362],[1914,1407],[271,1407]],"region":{"top_left_x":270,"top_left_y":1362,"width":1645,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c40737187224b569d43170cec52a171","type":"text","conversion_output":true,"text":"Detailed standardization of the surgical procedure will be developed and will include the following","text_display":"\n\nDetailed standardization of the surgical procedure will be developed and will include the following","confidence":1,"confidence_rate":1},{"cnt":[[146,1409],[333,1409],[333,1452],[146,1452]],"region":{"top_left_x":146,"top_left_y":1409,"width":188,"height":44},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ca81fc2aee546c4862bd9794ad9eed9","type":"text","conversion_output":true,"text":"key points:","text_display":" key points:","confidence":1,"confidence_rate":1},{"cnt":[[275,1452],[1846,1452],[1846,1497],[275,1497]],"region":{"top_left_x":275,"top_left_y":1452,"width":1571,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5edc9e69a914d3bab2a901777b748de","type":"text","conversion_output":true,"text":"1. The participating surgeon must be present and scrubbed for key portions of the procedure.","text_display":"\n1. The participating surgeon must be present and scrubbed for key portions of the procedure.","confidence":1,"confidence_rate":1},{"cnt":[[146,1495],[1641,1495],[1641,1540],[146,1540]],"region":{"top_left_x":146,"top_left_y":1495,"width":1496,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d59e1d12340c406e9f58b9d53d9fe68e","type":"text","conversion_output":true,"text":"Residents and fellows may participate in procedures as is standard for each Clinical Site","text_display":" Residents and fellows may participate in procedures as is standard for each Clinical Site","confidence":0.99951171875,"confidence_rate":0.9999948042635181},{"cnt":[[271,1538],[1919,1538],[1919,1583],[271,1583]],"region":{"top_left_x":270,"top_left_y":1538,"width":1649,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de8cce0476cb498692634797723dcf93","type":"text","conversion_output":true,"text":"2. All subjects will receive preoperative intravenous antibiotic prophylaxis. The choice of antibiotic","text_display":"\n2. All subjects will receive preoperative intravenous antibiotic prophylaxis. The choice of antibiotic","confidence":1,"confidence_rate":1},{"cnt":[[146,1583],[763,1583],[763,1626],[146,1626]],"region":{"top_left_x":146,"top_left_y":1583,"width":617,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5357c8a39598488395139d58c251c550","type":"text","conversion_output":true,"text":"will be determined by each surgeon.","text_display":" will be determined by each surgeon.","confidence":1,"confidence_rate":1},{"cnt":[[271,1626],[1962,1626],[1962,1669],[271,1669]],"region":{"top_left_x":270,"top_left_y":1626,"width":1692,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efde8ba5b59c48559b581f19b6a8bf31","type":"text","conversion_output":true,"text":"3. Deep vein thrombosis prophylaxis is required for all participants. The choice of prophylaxis will be","text_display":"\n3. Deep vein thrombosis prophylaxis is required for all participants. The choice of prophylaxis will be","confidence":1,"confidence_rate":1},{"cnt":[[146,1671],[647,1671],[647,1714],[146,1714]],"region":{"top_left_x":146,"top_left_y":1671,"width":501,"height":44},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f66e0c037f53414ab70f7f71150665f9","type":"text","conversion_output":true,"text":"determined by each surgeon.","text_display":" determined by each surgeon.","confidence":1,"confidence_rate":1},{"cnt":[[271,1714],[1962,1714],[1962,1760],[271,1760]],"region":{"top_left_x":270,"top_left_y":1714,"width":1692,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dfa8748564146378e4a7936d5056611","type":"text","conversion_output":true,"text":"4. Any concomitant native tissue procedures must be declared prior to randomization. Per exclusion","text_display":"\n4. Any concomitant native tissue procedures must be declared prior to randomization. Per exclusion","confidence":1,"confidence_rate":1},{"cnt":[[146,1757],[1669,1757],[1669,1803],[146,1803]],"region":{"top_left_x":146,"top_left_y":1757,"width":1524,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e6d21c784b845e2928bd6b0dd9a9f6d","type":"text","conversion_output":true,"text":"criteria, women clinically requiring anterior vaginal prolapse or apical repairs are ineligible.","text_display":" criteria, women clinically requiring anterior vaginal prolapse or apical repairs are ineligible.","confidence":1,"confidence_rate":1},{"cnt":[[271,1800],[1951,1800],[1951,1846],[271,1846]],"region":{"top_left_x":270,"top_left_y":1800,"width":1681,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6af85a9fa3ca4346b45000d3f2cf2c79","type":"text","conversion_output":true,"text":"5. Tensioning of the sling will be performed in a fashion to ensure that it is a tension-free technique.","text_display":"\n5. Tensioning of the sling will be performed in a fashion to ensure that it is a tension-free technique.","confidence":1,"confidence_rate":1},{"cnt":[[146,1846],[1970,1846],[1970,1893],[146,1893]],"region":{"top_left_x":146,"top_left_y":1845,"width":1825,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c22ffa035df14ece90ca2cc851bb1bbc","type":"text","conversion_output":true,"text":"This can include either by placing a blunt instrument between the sling and the urethra, or by folding a small","text_display":" This can include either by placing a blunt instrument between the sling and the urethra, or by folding a small","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[146,1891],[1386,1891],[1386,1936],[146,1936]],"region":{"top_left_x":146,"top_left_y":1890,"width":1240,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5a5605704b14074aa14d74fa51878c1","type":"text","conversion_output":true,"text":"knuckle of mesh in a Babcock clamp or similar method during tensioning.","text_display":" knuckle of mesh in a Babcock clamp or similar method during tensioning.","confidence":1,"confidence_rate":1},{"cnt":[[144,1977],[887,1977],[887,2024],[144,2024]],"region":{"top_left_x":143,"top_left_y":1976,"width":745,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9a8864f89fd467789620588d0a0eb5e","type":"section_header","conversion_output":false,"children_ids":["46be42567a754c57b565a149194350c7"],"text":"","text_display":""},{"cnt":[[146,1981],[885,1981],[885,2022],[146,2022]],"region":{"top_left_x":146,"top_left_y":1980,"width":740,"height":42},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46be42567a754c57b565a149194350c7","type":"text","conversion_output":true,"parent_id":"c9a8864f89fd467789620588d0a0eb5e","text":"5.1.c. Need for postoperative sling revision:","text_display":"\n\n\\section*{5.1.c. Need for postoperative sling revision:}","confidence":0.99951171875,"confidence_rate":0.9999902320377447},{"cnt":[[271,2022],[1962,2022],[1962,2067],[271,2067]],"region":{"top_left_x":270,"top_left_y":2021,"width":1692,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84f9d08536de4065bb31c968ee51d34c","type":"text","conversion_output":true,"text":"To address the issue of postoperative sling revision, the team developed a plan for several potential","text_display":"\n\nTo address the issue of postoperative sling revision, the team developed a plan for several potential","confidence":1,"confidence_rate":1},{"cnt":[[146,2067],[1927,2067],[1927,2112],[146,2112]],"region":{"top_left_x":146,"top_left_y":2066,"width":1782,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e593798018e4883bd52a4a7582632c2","type":"text","conversion_output":true,"text":"scenarios which may require the surgeon to revise the sling, detailed below. Women who undergo a sling","text_display":" scenarios which may require the surgeon to revise the sling, detailed below. Women who undergo a sling","confidence":1,"confidence_rate":1},{"cnt":[[146,2110],[1964,2110],[1964,2155],[146,2155]],"region":{"top_left_x":146,"top_left_y":2109,"width":1818,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7da5e20495f546bab6384232bb26b7ee","type":"text","conversion_output":true,"text":"revision will all be considered as having \"additional treatment\" in outcome analyses regardless of indication.","text_display":" revision will all be considered as having \"additional treatment\" in outcome analyses regardless of indication.","confidence":1,"confidence_rate":1},{"cnt":[[146,2153],[1966,2153],[1966,2198],[146,2198]],"region":{"top_left_x":146,"top_left_y":2152,"width":1820,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"526f62f3297145ef9216c0a40a4c3bdf","type":"text","conversion_output":true,"text":"Prior to sling revision, subjects will complete all outcome assessments including the primary outcome (UDI).","text_display":" Prior to sling revision, subjects will complete all outcome assessments including the primary outcome (UDI).","confidence":1,"confidence_rate":1},{"cnt":[[271,2196],[1974,2196],[1974,2241],[271,2241]],"region":{"top_left_x":270,"top_left_y":2195,"width":1705,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4afb1e078884ff3b62d3816981c9659","type":"text","conversion_output":true,"text":"1. Urinary retention / incomplete bladder emptying (abnormal PVR) - An abnormal post-void residual","text_display":"\n1. Urinary retention / incomplete bladder emptying (abnormal PVR) - An abnormal post-void residual","confidence":0.9868464469909668,"confidence_rate":0.9998714565425912},{"cnt":[[146,2243],[1957,2243],[1957,2288],[146,2288]],"region":{"top_left_x":146,"top_left_y":2242,"width":1812,"height":47},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90f9e41db6f84cbe994673a6c9a77b24","type":"text","conversion_output":true,"text":"is defined as PVR \\(>150 cc\\) in this protocol (consistent with exclusion criteria). This is a known complication","text_display":" is defined as PVR \\(>150 cc\\) in this protocol (consistent with exclusion criteria). This is a known complication","confidence":0.6539773941040039,"confidence_rate":0.9964376000056482},{"cnt":[[146,2286],[1884,2286],[1884,2331],[146,2331]],"region":{"top_left_x":146,"top_left_y":2285,"width":1739,"height":47},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"988afca6a1d549dc8373cff740559851","type":"text","conversion_output":true,"text":"after MUS, and there is no evidence to support that this would be higher in women with MUI. Based on","text_display":" after MUS, and there is no evidence to support that this would be higher in women with MUI. Based on","confidence":1,"confidence_rate":1},{"cnt":[[146,2329],[1807,2329],[1807,2374],[146,2374]],"region":{"top_left_x":146,"top_left_y":2328,"width":1661,"height":47},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9752e75f150b4901933d85d86f4fb87b","type":"text","conversion_output":true,"text":"Barber's trial which included \\(70 \\%\\) women with MUI, the sling revision rate was \\(0-1 \\%\\), which is also","text_display":" Barber's trial which included \\(70 \\%\\) women with MUI, the sling revision rate was \\(0-1 \\%\\), which is also","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[146,2372],[1910,2372],[1910,2417],[146,2417]],"region":{"top_left_x":146,"top_left_y":2371,"width":1764,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb00cd7f462f47a0a7c0990bdff1543a","type":"text","conversion_output":true,"text":"consistent with the TOMUS trial. For retention/incomplete emptying, the postoperative management and","text_display":" consistent with the TOMUS trial. For retention/incomplete emptying, the postoperative management and","confidence":1,"confidence_rate":1},{"cnt":[[146,2417],[1343,2417],[1343,2460],[146,2460]],"region":{"top_left_x":146,"top_left_y":2416,"width":1197,"height":44},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2da6cae1c333450a9f07eef9c31d57dc","type":"text","conversion_output":true,"text":"need for sling revision will be left up to the surgeon's clinical judgment.","text_display":" need for sling revision will be left up to the surgeon's clinical judgment.","confidence":0.99951171875,"confidence_rate":0.9999938950124092},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1a3ba8e011d484186fe0111203592d1","type":"page_info","conversion_output":false,"text":"30","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1828a276c284a1dad1776b5855a2f33","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-31","page":31,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a849bc8ef3ac4ca39cdbd2d3aac26f74","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"113ce09f226245e894319ddfca2b0106","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83dab4a23ff5453088573e019f408403","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[357,215],[357,256],[146,256]],"region":{"top_left_x":146,"top_left_y":214,"width":211,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"369fca18950746e188d6b978b9cfcbb6","type":"section_header","conversion_output":false,"children_ids":["1fb43126d054438ea14f5c3f7d2d8fe3"],"text":"","text_display":""},{"cnt":[[148,217],[354,217],[354,251],[148,251]],"region":{"top_left_x":148,"top_left_y":216,"width":207,"height":36},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fb43126d054438ea14f5c3f7d2d8fe3","type":"text","conversion_output":true,"parent_id":"369fca18950746e188d6b978b9cfcbb6","text":"Confidential","text_display":"\n\n\\section*{Confidential}","confidence":1,"confidence_rate":1},{"cnt":[[271,262],[1858,262],[1858,303],[271,303]],"region":{"top_left_x":270,"top_left_y":262,"width":1589,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7e6f407c69f4b37bf21fec118bd5c6c","type":"text","conversion_output":true,"text":"2. Worsening OAB /lower urinary tract symptoms with a normal PVR - it is possible that some","text_display":"\n2. Worsening OAB /lower urinary tract symptoms with a normal PVR - it is possible that some","confidence":0.6278591236894044,"confidence_rate":0.9954472632787751},{"cnt":[[146,305],[1865,305],[1865,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1719,"height":41},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0510015ee70044538b855016d354549b","type":"text","conversion_output":true,"text":"women may experience worsening OAB symptoms immediately postoperatively. It is unclear from the","text_display":" women may experience worsening OAB symptoms immediately postoperatively. It is unclear from the","confidence":0.99658203125,"confidence_rate":0.9999657623526261},{"cnt":[[148,348],[1863,348],[1863,391],[148,391]],"region":{"top_left_x":148,"top_left_y":348,"width":1715,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1f6688974e445289dfa64e3d8e33e97","type":"text","conversion_output":true,"text":"literature in which women such symptoms may be transient and ultimately resolve once postoperative","text_display":" literature in which women such symptoms may be transient and ultimately resolve once postoperative","confidence":1,"confidence_rate":1},{"cnt":[[148,391],[1846,391],[1846,436],[148,436]],"region":{"top_left_x":148,"top_left_y":391,"width":1698,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1803c1c71e24282bb8050f4aed0eb0e","type":"text","conversion_output":true,"text":"recovery is complete, or in which women it will persist and/or worsen over time (an aim of ESTEEM).","text_display":" recovery is complete, or in which women it will persist and/or worsen over time (an aim of ESTEEM).","confidence":1,"confidence_rate":1},{"cnt":[[146,436],[1919,436],[1919,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1773,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d1f520387894e759dcf5e0abe75eb3f","type":"text","conversion_output":true,"text":"Therefore, for women with a normal PVR complaining of worsening OAB symptoms, sling revision will be","text_display":" Therefore, for women with a normal PVR complaining of worsening OAB symptoms, sling revision will be","confidence":1,"confidence_rate":1},{"cnt":[[146,481],[1940,481],[1940,522],[146,522]],"region":{"top_left_x":146,"top_left_y":481,"width":1795,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e8aac601cb44f6994249be6c2f93ee6","type":"text","conversion_output":true,"text":"deferred until 3 months postoperatively. This will provide important information about the natural course of","text_display":" deferred until 3 months postoperatively. This will provide important information about the natural course of","confidence":0.99365234375,"confidence_rate":0.9999451059180913},{"cnt":[[146,524],[1940,524],[1940,567],[146,567]],"region":{"top_left_x":146,"top_left_y":524,"width":1795,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a9a512ee93c435881dd2f8bf306548a","type":"text","conversion_output":true,"text":"these symptoms in the immediate postoperative period, and whether BPTx is effective for improving these","text_display":" these symptoms in the immediate postoperative period, and whether BPTx is effective for improving these","confidence":1,"confidence_rate":1},{"cnt":[[146,567],[1974,567],[1974,610],[146,610]],"region":{"top_left_x":146,"top_left_y":567,"width":1829,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3aecf74ca8d4caaa5a9ab169fb2058f","type":"text","conversion_output":true,"text":"symptoms early on. If after 3 months the patient desires sling revision due to worsening OAB symptoms, the","text_display":" symptoms early on. If after 3 months the patient desires sling revision due to worsening OAB symptoms, the","confidence":0.97900390625,"confidence_rate":0.9998138800731758},{"cnt":[[146,610],[1966,610],[1966,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1820,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c626e44121344b32a782e8a715d3ede7","type":"text","conversion_output":true,"text":"surgeon can perform the procedure based on his/her clinical judgment. There is no evidence to support any","text_display":" surgeon can perform the procedure based on his/her clinical judgment. There is no evidence to support any","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[1721,655],[1721,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1575,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d833554e9aa4d11a21cc05a70245ecb","type":"text","conversion_output":true,"text":"potential harm by delaying sling revision in a woman with OAB symptoms and a normal PVR.","text_display":" potential harm by delaying sling revision in a woman with OAB symptoms and a normal PVR.","confidence":0.9103696346282959,"confidence_rate":0.9989907830426983},{"cnt":[[271,700],[1691,700],[1691,741],[271,741]],"region":{"top_left_x":270,"top_left_y":700,"width":1421,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"817d87c7c77743d5a6d53daa01aa6b94","type":"text","conversion_output":true,"text":"3. Persistent SUI symptoms - For women who have persistent SUI symptoms, sling","text_display":"\n3. Persistent SUI symptoms - For women who have persistent SUI symptoms, sling","confidence":1,"confidence_rate":1},{"cnt":[[146,743],[1779,743],[1779,786],[146,786]],"region":{"top_left_x":146,"top_left_y":743,"width":1633,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc4a04374a3243aa8e0db41c8b6034d9","type":"text","conversion_output":true,"text":"revision/replacement can be performed after 3 months based on the surgeon's clinical judgment.","text_display":" revision/replacement can be performed after 3 months based on the surgeon's clinical judgment.","confidence":1,"confidence_rate":1},{"cnt":[[146,827],[801,827],[801,874],[146,874]],"region":{"top_left_x":146,"top_left_y":827,"width":656,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d6fe40440664024bf1c2cc1948adb88","type":"section_header","conversion_output":false,"children_ids":["a95c647e7541499eb5eef41a0533155c"],"text":"","text_display":""},{"cnt":[[146,829],[797,829],[797,870],[146,870]],"region":{"top_left_x":146,"top_left_y":829,"width":652,"height":42},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a95c647e7541499eb5eef41a0533155c","type":"text","conversion_output":true,"parent_id":"5d6fe40440664024bf1c2cc1948adb88","text":"5.2. Background for BPTx intervention","text_display":"\n\n\\subsection*{5.2. Background for BPTx intervention}","confidence":1,"confidence_rate":1},{"cnt":[[271,883],[1888,883],[1888,926],[271,926]],"region":{"top_left_x":270,"top_left_y":883,"width":1619,"height":43},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac046d093c064d3a831b3bbed52e3407","type":"text","conversion_output":true,"text":"To develop the most evidence-based, reproducible, standardized, and logical BPTx intervention","text_display":"\n\nTo develop the most evidence-based, reproducible, standardized, and logical BPTx intervention","confidence":1,"confidence_rate":1},{"cnt":[[146,928],[1775,928],[1775,969],[146,969]],"region":{"top_left_x":146,"top_left_y":928,"width":1629,"height":41},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6138a31795814bd48b20eb21751c6e82","type":"text","conversion_output":true,"text":"protocol, the team reviewed the evidence and determined that bladder training/urge suppression","text_display":" protocol, the team reviewed the evidence and determined that bladder training/urge suppression","confidence":1,"confidence_rate":1},{"cnt":[[146,971],[1964,971],[1964,1016],[146,1016]],"region":{"top_left_x":146,"top_left_y":971,"width":1818,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"987b33a413e5455abb097e93dd0e5b35","type":"text","conversion_output":true,"text":"techniques, pelvic floor muscle therapy, and weight loss have high level of evidence for treatment of urinary","text_display":" techniques, pelvic floor muscle therapy, and weight loss have high level of evidence for treatment of urinary","confidence":1,"confidence_rate":1},{"cnt":[[146,1014],[1768,1014],[1768,1059],[146,1059]],"region":{"top_left_x":146,"top_left_y":1014,"width":1623,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d55cf10ced394ef7b3bc8251c743a206","type":"text","conversion_output":true,"text":"incontinence. Therefore, weight loss will be discussed with all women, and bladder training/urge","text_display":" incontinence. Therefore, weight loss will be discussed with all women, and bladder training/urge","confidence":1,"confidence_rate":1},{"cnt":[[146,1059],[1807,1059],[1807,1102],[146,1102]],"region":{"top_left_x":146,"top_left_y":1059,"width":1661,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8e74a20d2cc4481a6e308f5b31e5c61","type":"text","conversion_output":true,"text":"suppression and pelvic muscle exercises will be incorporated into the ESTEEM BPTx intervention.","text_display":" suppression and pelvic muscle exercises will be incorporated into the ESTEEM BPTx intervention.","confidence":1,"confidence_rate":1},{"cnt":[[271,1104],[1914,1104],[1914,1145],[271,1145]],"region":{"top_left_x":270,"top_left_y":1104,"width":1645,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88e495811d1e4a5db2280dce9f666a11","type":"text","conversion_output":true,"text":"The summary of evidence for 5 key questions relevant to our intervention are summarized below:","text_display":"\n\nThe summary of evidence for 5 key questions relevant to our intervention are summarized below:","confidence":1,"confidence_rate":1},{"cnt":[[146,1186],[1231,1186],[1231,1233],[146,1233]],"region":{"top_left_x":146,"top_left_y":1185,"width":1086,"height":49},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0510f6ab195146499c973933230b604a","type":"section_header","conversion_output":false,"children_ids":["446f7348a5534de5a3391ed049237734"],"text":"","text_display":""},{"cnt":[[148,1190],[1229,1190],[1229,1231],[148,1231]],"region":{"top_left_x":148,"top_left_y":1190,"width":1081,"height":42},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"446f7348a5534de5a3391ed049237734","type":"text","conversion_output":true,"parent_id":"0510f6ab195146499c973933230b604a","text":"5.2.1. What is the evidence for behavioral/lifestyle modification?","text_display":"\n\n\\subsection*{5.2.1. What is the evidence for behavioral/lifestyle modification?}","confidence":1,"confidence_rate":1},{"cnt":[[271,1242],[1946,1242],[1946,1287],[271,1287]],"region":{"top_left_x":270,"top_left_y":1241,"width":1677,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7e01e817f91424c8620e9447d7cf81f","type":"text","conversion_output":true,"text":"There are many components that can be defined as \"behavioral\" or \"lifestyle\" modification including","text_display":"\n\nThere are many components that can be defined as \"behavioral\" or \"lifestyle\" modification including","confidence":1,"confidence_rate":1},{"cnt":[[146,1285],[1923,1285],[1923,1330],[146,1330]],"region":{"top_left_x":146,"top_left_y":1284,"width":1777,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4797e7446c34cc2a0ac5f351ddd3ea7","type":"text","conversion_output":true,"text":"caffeine intake, fluid intake, obesity, smoking, constipation and timed voiding. A summary of ICI evidence","text_display":" caffeine intake, fluid intake, obesity, smoking, constipation and timed voiding. A summary of ICI evidence","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[146,1332],[690,1332],[690,1369],[146,1369]],"region":{"top_left_x":146,"top_left_y":1332,"width":544,"height":37},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc5951e4ebff41bbb0e9f6c823d23dc8","type":"text","conversion_output":true,"text":"and recommendations is below:","text_display":" and recommendations is below:","confidence":1,"confidence_rate":1},{"cnt":[[146,1418],[926,1418],[926,1463],[146,1463]],"region":{"top_left_x":146,"top_left_y":1417,"width":780,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f0352a403fb4e30b583195efa858f4b","type":"figure_label","conversion_output":false,"text":"Table 9. 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Caffeine intake & 2 & B & Caffeine reduction may improve incontinence \\\\\n\\hline 2. Fluid intake & 3 & B & Minor decreases by 25\\% may be recommended provided baseline consumption is not less than one liter a day \\\\\n\\hline 3. Weight loss & 1 & A & Morbidly and moderately obese women should consider weight loss to reduce UI \\\\\n\\hline 4. Smoking & 3 & None & More research \\\\\n\\hline 5. Constipation & 3 & None & More research \\\\\n\\hline 6. Timed voiding & 3 & C & Two-hour voiding intervals in women with mild UI and infrequent voiding patterns \\\\\n\\hline 7. Bladder training/urge suppression & 1 & A & Recommended for UI reduction \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 9. Summary of ICI recommendations}\n\\begin{tabular}{|l|l|l|l|}\n\\hline Modification & Level of evidence & Grade of recommendation & Recommendation \\\\\n\\hline 1. Caffeine intake & 2 & B & Caffeine reduction may improve incontinence \\\\\n\\hline 2. Fluid intake & 3 & B & Minor decreases by 25\\% may be recommended provided baseline consumption is not less than one liter a day \\\\\n\\hline 3. Weight loss & 1 & A & Morbidly and moderately obese women should consider weight loss to reduce UI \\\\\n\\hline 4. Smoking & 3 & None & More research \\\\\n\\hline 5. Constipation & 3 & None & More research \\\\\n\\hline 6. Timed voiding & 3 & C & Two-hour voiding intervals in women with mild UI and infrequent voiding patterns \\\\\n\\hline 7. 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system stimulant and animal research has","text_display":" excitability. \\({ }^{81-83}\\) In addition, caffeine is a central nervous system stimulant and animal research has","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[146,2219],[1944,2219],[1944,2262],[146,2262]],"region":{"top_left_x":146,"top_left_y":2219,"width":1799,"height":44},"line":91,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5d7341912a54281be36d41a63b0be50","type":"text","conversion_output":true,"text":"suggested that caffeine increases calcium release from smooth muscle leading to excitatory contraction of","text_display":" suggested that caffeine increases calcium release from smooth muscle leading to excitatory contraction of","confidence":0.99853515625,"confidence_rate":0.9999866735644114},{"cnt":[[146,2260],[1966,2260],[1966,2305],[146,2305]],"region":{"top_left_x":146,"top_left_y":2260,"width":1820,"height":46},"line":92,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"888a0725f8f7421f8476a792d7fab162","type":"text","conversion_output":true,"text":"smooth muscle organs like the bladder. \\({ }^{84}\\) Few well designed studies have addressed the impact of caffeine","text_display":" smooth muscle organs like the bladder. \\({ }^{84}\\) Few well designed studies have addressed the impact of caffeine","confidence":1,"confidence_rate":1},{"cnt":[[146,2307],[1910,2307],[1910,2348],[146,2348]],"region":{"top_left_x":146,"top_left_y":2307,"width":1764,"height":42},"line":93,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5c4b6e2215446a5853ca96941834492","type":"text","conversion_output":true,"text":"on bladder symptoms and those that have produced conflicting results, but there are some small studies","text_display":" on bladder symptoms and those that have produced conflicting results, but there are some small studies","confidence":1,"confidence_rate":1},{"cnt":[[146,2348],[1141,2348],[1141,2396],[146,2396]],"region":{"top_left_x":146,"top_left_y":2348,"width":995,"height":48},"line":94,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f845029a9e34267840954c0f737b175","type":"text","conversion_output":true,"text":"suggesting decreasing caffeine may improve continence. \\({ }^{85}\\)","text_display":" suggesting decreasing caffeine may improve continence. \\({ }^{85}\\)","confidence":0.99755859375,"confidence_rate":0.9999640537145865},{"cnt":[[146,2436],[1794,2436],[1794,2481],[146,2481]],"region":{"top_left_x":146,"top_left_y":2436,"width":1648,"height":46},"line":95,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b5acfce30e94054a015d094301cf712","type":"text","conversion_output":true,"text":"Fluid intake: Excessive fluid intake can certainly increase urinary frequency and exacerbate OAB","text_display":"\n\nFluid intake: Excessive fluid intake can certainly increase urinary frequency and exacerbate OAB","confidence":0.98291015625,"confidence_rate":0.9998293456470753},{"cnt":[[146,2479],[1833,2479],[1833,2529],[146,2529]],"region":{"top_left_x":146,"top_left_y":2479,"width":1687,"height":50},"line":96,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21b06563002f41998e93f7e5eb28c3d3","type":"text","conversion_output":true,"text":"symptoms. \\({ }^{86}\\) Interestingly, excessive restriction of fluid may also exacerbate symptoms due to poor","text_display":" symptoms. \\({ }^{86}\\) Interestingly, excessive restriction of fluid may also exacerbate symptoms due to poor","confidence":0.9985356330871582,"confidence_rate":0.9999871453444995},{"cnt":[[1038,2548],[1083,2548],[1083,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":46,"height":46},"line":97,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46d37483b1f34a99aa8c2625f02ca0e4","type":"page_info","conversion_output":false,"text":"31","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14eb7b87ab34441a95e7e242a1a7ecde","type":"page_info","conversion_output":false,"text":"Version 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Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dda46f4725f4ba4854da78ab626d927","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71ff10a97056488b922212c183f679d4","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13d179bdc7fb40f282d69b4de28cebaf","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1966,260],[1966,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1820,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"238c47886a02434b9e5de2334c736ebd","type":"text","conversion_output":true,"text":"elimination of irritants from the bladder, decreasing the functional capacity of the bladder and increasing the","text_display":"\nelimination of irritants from the bladder, decreasing the functional capacity of the bladder and increasing the","confidence":1,"confidence_rate":1},{"cnt":[[146,303],[1931,303],[1931,346],[146,346]],"region":{"top_left_x":146,"top_left_y":302,"width":1786,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66c0b43642f64ff3999ab631abb5744a","type":"text","conversion_output":true,"text":"risk of urinary tract infections. \\({ }^{87}\\) Appropriate fluid intake should be balanced against activity level, climate,","text_display":" risk of urinary tract infections. \\({ }^{87}\\) Appropriate fluid intake should be balanced against activity level, climate,","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[1886,348],[1886,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1741,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8c307a871884db1ba34b150a1bca0f5","type":"text","conversion_output":true,"text":"and fluid content of ingested foods. For most older adults, fluid intake should be approximately six \\(8- oz\\)","text_display":" and fluid content of ingested foods. For most older adults, fluid intake should be approximately six \\(8- oz\\)","confidence":0.7227428196929395,"confidence_rate":0.9971050748928606},{"cnt":[[146,391],[458,391],[458,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":312,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9195ecf5c7bb4938a6a8dfaabe8d1316","type":"text","conversion_output":true,"text":"glasses per day. \\({ }^{88}\\)","text_display":" glasses per day. \\({ }^{88}\\)","confidence":1,"confidence_rate":1},{"cnt":[[150,481],[1906,481],[1906,522],[150,522]],"region":{"top_left_x":150,"top_left_y":481,"width":1756,"height":42},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8459654fb9ad4a4aa0fe2a5a790aa61c","type":"text","conversion_output":true,"text":"Weight loss: Obesity, defined as a body mass index greater than or equal to \\(30 kg / m 2\\), was traditionally","text_display":"\n\nWeight loss: Obesity, defined as a body mass index greater than or equal to \\(30 kg / m 2\\), was traditionally","confidence":1,"confidence_rate":1},{"cnt":[[148,524],[1919,524],[1919,567],[148,567]],"region":{"top_left_x":148,"top_left_y":524,"width":1771,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e9a250005ad4026b3d3536861c3396e","type":"text","conversion_output":true,"text":"considered a risk factor for SUI only but more recently has been appreciated as a risk factor for OAB and","text_display":" considered a risk factor for SUI only but more recently has been appreciated as a risk factor for OAB and","confidence":1,"confidence_rate":1},{"cnt":[[148,567],[1940,567],[1940,612],[148,612]],"region":{"top_left_x":148,"top_left_y":567,"width":1793,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d80188fe5ab4362b3b38df8dddc3f9d","type":"text","conversion_output":true,"text":"UUI as well. \\({ }^{89,90}\\) Bump et al showed improvement in both SUI and UUI following surgical weight reduction","text_display":" UUI as well. \\({ }^{89,90}\\) Bump et al showed improvement in both SUI and UUI following surgical weight reduction","confidence":1,"confidence_rate":1},{"cnt":[[146,610],[1955,610],[1955,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1810,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d2239ad5a6944ce955cbafd869cff13","type":"text","conversion_output":true,"text":"in morbidly obese women. \\({ }^{91}\\) But, even moderate weight loss can improve bladder symptoms in overweight","text_display":" in morbidly obese women. \\({ }^{91}\\) But, even moderate weight loss can improve bladder symptoms in overweight","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[1974,655],[1974,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1829,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c191bdcb27b046059fa41254843e51d5","type":"text","conversion_output":true,"text":"women. A large randomized trial demonstrated that a structured weight loss intervention group resulting in a","text_display":" women. A large randomized trial demonstrated that a structured weight loss intervention group resulting in a","confidence":1,"confidence_rate":1},{"cnt":[[146,700],[1811,700],[1811,741],[146,741]],"region":{"top_left_x":146,"top_left_y":700,"width":1666,"height":42},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a120bbad2f4d4a3aa9e9584e6122cd96","type":"text","conversion_output":true,"text":"loss of 8\\% of body weight was associated with a clinically relevant reduction of 70\\% or more in the","text_display":" loss of 8\\% of body weight was associated with a clinically relevant reduction of 70\\% or more in the","confidence":0.9781552647729086,"confidence_rate":0.9997876488563173},{"cnt":[[146,743],[1931,743],[1931,786],[146,786]],"region":{"top_left_x":146,"top_left_y":743,"width":1786,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8182d28377b94571ac4b6d6c6d705284","type":"text","conversion_output":true,"text":"frequency of all IEs ( \\(P <.001\\) ), SUI ( \\(P =.009\\) ), and urge IEs ( \\(P =.04\\) ) compared to a control group which only","text_display":" frequency of all IEs ( \\(P <.001\\) ), SUI ( \\(P =.009\\) ), and urge IEs ( \\(P =.04\\) ) compared to a control group which only","confidence":0.9951212396845222,"confidence_rate":0.9999632284932511},{"cnt":[[146,784],[645,784],[645,831],[146,831]],"region":{"top_left_x":146,"top_left_y":784,"width":499,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a839d2b542c042bb90a134f91dcf97c7","type":"text","conversion_output":true,"text":"lost \\(1.6 \\%\\) of body weight. \\({ }^{90,92}\\)","text_display":" lost \\(1.6 \\%\\) of body weight. \\({ }^{90,92}\\)","confidence":0.9365541934967041,"confidence_rate":0.9985444405634841},{"cnt":[[150,872],[1974,872],[1974,917],[150,917]],"region":{"top_left_x":150,"top_left_y":872,"width":1825,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0feeb765d603454f8693d0ea4ba3a0db","type":"text","conversion_output":true,"text":"Smoking: Smoking, particularly nicotine, has been implicated as a risk factor for OAB and incontinence. \\({ }^{93,94}\\)","text_display":"\n\nSmoking: Smoking, particularly nicotine, has been implicated as a risk factor for OAB and incontinence. \\({ }^{93,94}\\)","confidence":0.9990236759185791,"confidence_rate":0.999991860024828},{"cnt":[[146,920],[1876,920],[1876,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1730,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23164260bbf442bab055d2b492c362d9","type":"text","conversion_output":true,"text":"Potential etiologies are increased intra-abdominal pressure from chronic cough and increased nicotine","text_display":" Potential etiologies are increased intra-abdominal pressure from chronic cough and increased nicotine","confidence":1,"confidence_rate":1},{"cnt":[[146,958],[1919,958],[1919,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":958,"width":1773,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"945e981ef76c4089bc40e35bf8392ff1","type":"text","conversion_output":true,"text":"induced detrusor overactivity (as shown in cats). \\({ }^{95}\\) Little clinical data is available assessing the impact of","text_display":" induced detrusor overactivity (as shown in cats). \\({ }^{95}\\) Little clinical data is available assessing the impact of","confidence":0.99951171875,"confidence_rate":0.9999960928036482},{"cnt":[[146,1008],[849,1008],[849,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1007,"width":703,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94b980321a994146ae6bcdce4398df1b","type":"text","conversion_output":true,"text":"smoking cessation on bladder symptoms.","text_display":" smoking cessation on bladder symptoms.","confidence":1,"confidence_rate":1},{"cnt":[[150,1091],[1828,1091],[1828,1139],[150,1139]],"region":{"top_left_x":150,"top_left_y":1091,"width":1679,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f34cd6164a046c8916a247fca43178d","type":"text","conversion_output":true,"text":"Constipation: Constipation is a common co-morbid complaint among patients with OAB and UI. \\({ }^{96-98}\\)","text_display":"\n\nConstipation: Constipation is a common co-morbid complaint among patients with OAB and UI. \\({ }^{96-98}\\)","confidence":0.87060546875,"confidence_rate":0.9987058253793933},{"cnt":[[146,1139],[1968,1139],[1968,1182],[146,1182]],"region":{"top_left_x":146,"top_left_y":1138,"width":1822,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8e66a5982034a139d1b62f1bfb86ce0","type":"text","conversion_output":true,"text":"Although several studies in children document that constipation is linked to urinary tract symptoms including","text_display":" Although several studies in children document that constipation is linked to urinary tract symptoms including","confidence":1,"confidence_rate":1},{"cnt":[[146,1182],[1833,1182],[1833,1227],[146,1227]],"region":{"top_left_x":146,"top_left_y":1181,"width":1687,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0b7979744074aa3a1a9cb27539bb418","type":"text","conversion_output":true,"text":"infection, enuresis, voiding problems and vesicoureteral reflux, the majority of studies in adults have","text_display":" infection, enuresis, voiding problems and vesicoureteral reflux, the majority of studies in adults have","confidence":1,"confidence_rate":1},{"cnt":[[146,1225],[1901,1225],[1901,1270],[146,1270]],"region":{"top_left_x":146,"top_left_y":1224,"width":1756,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03b4ab17b20c41d89252ec242db85ec2","type":"text","conversion_output":true,"text":"identified an association but no clear causal link. While patients often report an exacerbation of bladder","text_display":" identified an association but no clear causal link. While patients often report an exacerbation of bladder","confidence":1,"confidence_rate":1},{"cnt":[[146,1270],[1811,1270],[1811,1313],[146,1313]],"region":{"top_left_x":146,"top_left_y":1269,"width":1666,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59bf2398e14c4524bae7f55184c46785","type":"text","conversion_output":true,"text":"symptoms during times of constipation, few clinical studies exists to suggest resolving constipation","text_display":" symptoms during times of constipation, few clinical studies exists to suggest resolving constipation","confidence":1,"confidence_rate":1},{"cnt":[[146,1315],[1818,1315],[1818,1358],[146,1358]],"region":{"top_left_x":146,"top_left_y":1314,"width":1672,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8408134c0b3041b4b65008fe5f45337d","type":"text","conversion_output":true,"text":"improves OAB symptoms. Promotion of bowel regularity initially through natural methods including","text_display":" improves OAB symptoms. Promotion of bowel regularity initially through natural methods including","confidence":0.857421875,"confidence_rate":0.9985634140754857},{"cnt":[[146,1358],[1815,1358],[1815,1403],[146,1403]],"region":{"top_left_x":146,"top_left_y":1357,"width":1670,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c51fcfb1b80422fac12e8320a0ad1b0","type":"text","conversion_output":true,"text":"increasing dietary fiber, increasing water intake, physical activity and use of stool softeners is often","text_display":" increasing dietary fiber, increasing water intake, physical activity and use of stool softeners is often","confidence":1,"confidence_rate":1},{"cnt":[[146,1401],[1798,1401],[1798,1446],[146,1446]],"region":{"top_left_x":146,"top_left_y":1400,"width":1653,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"411dd144c6574cd8b76fb83eb7a1d64e","type":"text","conversion_output":true,"text":"recommended because it is low risk; however the evidence for its effect on improving OAB or UUI","text_display":" recommended because it is low risk; however the evidence for its effect on improving OAB or UUI","confidence":1,"confidence_rate":1},{"cnt":[[146,1446],[1016,1446],[1016,1489],[146,1489]],"region":{"top_left_x":146,"top_left_y":1445,"width":871,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3782808da4de49fc86623b76ff525b6e","type":"text","conversion_output":true,"text":"symptoms in the general adult population is limited.","text_display":" symptoms in the general adult population is limited.","confidence":0.99951171875,"confidence_rate":0.9999914316069175},{"cnt":[[150,1534],[1833,1534],[1833,1577],[150,1577]],"region":{"top_left_x":150,"top_left_y":1533,"width":1683,"height":44},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32105dfc303240369524f85916f31cc1","type":"text","conversion_output":true,"text":"Timed Voiding: Timed voiding or prompted voiding is a mechanism to theoretically increase bladder","text_display":"\n\nTimed Voiding: Timed voiding or prompted voiding is a mechanism to theoretically increase bladder","confidence":1,"confidence_rate":1},{"cnt":[[146,1577],[1880,1577],[1880,1622],[146,1622]],"region":{"top_left_x":146,"top_left_y":1576,"width":1734,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24fe1f0a9b2943b7b0c2224965f42f4a","type":"text","conversion_output":true,"text":"awareness, although firm evidence for its effectiveness for UI does not exist. Timed voiding involves a","text_display":" awareness, although firm evidence for its effectiveness for UI does not exist. Timed voiding involves a","confidence":1,"confidence_rate":1},{"cnt":[[146,1620],[1897,1620],[1897,1665],[146,1665]],"region":{"top_left_x":146,"top_left_y":1619,"width":1752,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"388e76fb5c714f25ad6a5777d22f7343","type":"text","conversion_output":true,"text":"voiding schedule that starts with interval voiding on a fixed schedule regardless of the desire to go. \\({ }^{99}\\) It","text_display":" voiding schedule that starts with interval voiding on a fixed schedule regardless of the desire to go. \\({ }^{99}\\) It","confidence":1,"confidence_rate":1},{"cnt":[[146,1663],[1962,1663],[1962,1708],[146,1708]],"region":{"top_left_x":146,"top_left_y":1662,"width":1816,"height":47},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95f63b9e89aa4737b7a45ef8419e05d0","type":"text","conversion_output":true,"text":"involves patient cooperation, adequate mobility, and intact cognitive function. For some patients who delay","text_display":" involves patient cooperation, adequate mobility, and intact cognitive function. For some patients who delay","confidence":1,"confidence_rate":1},{"cnt":[[146,1710],[1893,1710],[1893,1753],[146,1753]],"region":{"top_left_x":146,"top_left_y":1710,"width":1747,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20127c860f3445a4a2f94c54ab92862d","type":"text","conversion_output":true,"text":"urination, initially decreasing the voiding interval to every 30-90 minutes may be necessary to decrease","text_display":" urination, initially decreasing the voiding interval to every 30-90 minutes may be necessary to decrease","confidence":0.85205078125,"confidence_rate":0.9985321869944187},{"cnt":[[146,1751],[1931,1751],[1931,1796],[146,1796]],"region":{"top_left_x":146,"top_left_y":1750,"width":1786,"height":47},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0dfcd8e760f4a60bb6e091a2d8f10f1","type":"text","conversion_output":true,"text":"incontinence episodes while urgency control strategies are being taught. \\({ }^{100}\\) The maintenance of the timed","text_display":" incontinence episodes while urgency control strategies are being taught. \\({ }^{100}\\) The maintenance of the timed","confidence":1,"confidence_rate":1},{"cnt":[[146,1796],[1863,1796],[1863,1841],[146,1841]],"region":{"top_left_x":146,"top_left_y":1796,"width":1717,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9046ef503ee44f8dada87802d80dcd1a","type":"text","conversion_output":true,"text":"voiding schedule during nighttime hours is determined by the patient's general sleep pattern (weather","text_display":" voiding schedule during nighttime hours is determined by the patient's general sleep pattern (weather","confidence":1,"confidence_rate":1},{"cnt":[[146,1839],[1944,1839],[1944,1884],[146,1884]],"region":{"top_left_x":146,"top_left_y":1839,"width":1799,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2eadf30868c04152bed3d42c3555c2ab","type":"text","conversion_output":true,"text":"he/she awakens naturally to void), their motivation to stay dry (whether he/she sets an alarm to make sure","text_display":" he/she awakens naturally to void), their motivation to stay dry (whether he/she sets an alarm to make sure","confidence":1,"confidence_rate":1},{"cnt":[[146,1884],[978,1884],[978,1927],[146,1927]],"region":{"top_left_x":146,"top_left_y":1884,"width":832,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd77222c51d048e4b97571f2fe568a56","type":"text","conversion_output":true,"text":"to awaken), and the availability of help if needed.","text_display":" to awaken), and the availability of help if needed.","confidence":1,"confidence_rate":1},{"cnt":[[144,2011],[1270,2011],[1270,2060],[144,2060]],"region":{"top_left_x":143,"top_left_y":2010,"width":1127,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b955c99eb2649a58b0b81dc3b1e1cb4","type":"section_header","conversion_output":false,"children_ids":["04df3d7d8e10414f8defeaf3d2529e0f"],"text":"","text_display":""},{"cnt":[[146,2015],[1265,2015],[1265,2058],[146,2058]],"region":{"top_left_x":146,"top_left_y":2015,"width":1120,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04df3d7d8e10414f8defeaf3d2529e0f","type":"text","conversion_output":true,"parent_id":"9b955c99eb2649a58b0b81dc3b1e1cb4","text":"5.2.2. What is the evidence for bladder training/urge suppression?","text_display":"\n\n\\subsection*{5.2.2. What is the evidence for bladder training/urge suppression?}","confidence":1,"confidence_rate":1},{"cnt":[[284,2069],[1951,2069],[1951,2112],[284,2112]],"region":{"top_left_x":283,"top_left_y":2068,"width":1668,"height":44},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eff4c329a42e4fffa6cb170c80d9ba7c","type":"text","conversion_output":true,"text":"Bladder training through urgency control and suppression techniques has been an effective means","text_display":"\n\nBladder training through urgency control and suppression techniques has been an effective means","confidence":1,"confidence_rate":1},{"cnt":[[146,2114],[1828,2114],[1828,2155],[146,2155]],"region":{"top_left_x":146,"top_left_y":2114,"width":1683,"height":41},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de26ba38eaf048848c04a1bfed5cd2ac","type":"text","conversion_output":true,"text":"of decreasing the intensity of urgency and incontinence in well motivated patients. Bladder training,","text_display":" of decreasing the intensity of urgency and incontinence in well motivated patients. Bladder training,","confidence":1,"confidence_rate":1},{"cnt":[[146,2157],[1927,2157],[1927,2200],[146,2200]],"region":{"top_left_x":146,"top_left_y":2157,"width":1782,"height":43},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b4c02afd6ae4564a1b157ebc4044310","type":"text","conversion_output":true,"text":"sometimes referred to as bladder retraining, bladder reeducation or bladder drills, may be effective as the","text_display":" sometimes referred to as bladder retraining, bladder reeducation or bladder drills, may be effective as the","confidence":1,"confidence_rate":1},{"cnt":[[146,2200],[1923,2200],[1923,2245],[146,2245]],"region":{"top_left_x":146,"top_left_y":2200,"width":1777,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e77a16863084df2b65f943ec6f4df97","type":"text","conversion_output":true,"text":"result of rewiring of complex circuitry between the bladder and the brain. \\({ }^{101}\\) The training consists of three","text_display":" result of rewiring of complex circuitry between the bladder and the brain. \\({ }^{101}\\) The training consists of three","confidence":1,"confidence_rate":1},{"cnt":[[146,2243],[1966,2243],[1966,2288],[146,2288]],"region":{"top_left_x":146,"top_left_y":2242,"width":1820,"height":47},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90b85283aba34a5cba705d300cf4c24b","type":"text","conversion_output":true,"text":"important components, (1) education about bladder function, dysfunction and urgency control strategies; (2)","text_display":" important components, (1) education about bladder function, dysfunction and urgency control strategies; (2)","confidence":1,"confidence_rate":1},{"cnt":[[146,2290],[1867,2290],[1867,2331],[146,2331]],"region":{"top_left_x":146,"top_left_y":2290,"width":1721,"height":42},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a508678dfdfa4468ba2810be6e2fd0d5","type":"text","conversion_output":true,"text":"a timed voiding regimen that evolves to gradually increase the interval between voids; and (3) positive","text_display":" a timed voiding regimen that evolves to gradually increase the interval between voids; and (3) positive","confidence":0.9878129959106445,"confidence_rate":0.9998864705695536},{"cnt":[[146,2331],[1914,2331],[1914,2376],[146,2376]],"region":{"top_left_x":146,"top_left_y":2331,"width":1769,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d4f84ebe43e45b8823eb3cd1b2aafd4","type":"text","conversion_output":true,"text":"feedback and reinforcement by caregivers. \\({ }^{102,103}\\) Utilization of relaxation techniques including slow deep","text_display":" feedback and reinforcement by caregivers. \\({ }^{102,103}\\) Utilization of relaxation techniques including slow deep","confidence":0.9824302196502686,"confidence_rate":0.9998535151843475},{"cnt":[[146,2376],[1970,2376],[1970,2419],[146,2419]],"region":{"top_left_x":146,"top_left_y":2376,"width":1825,"height":44},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf17bfc0d9574094bcf465b7ca96262b","type":"text","conversion_output":true,"text":"breathing and distraction techniques (mental concentration on other tasks) are most popular during urgency","text_display":" breathing and distraction techniques (mental concentration on other tasks) are most popular during urgency","confidence":1,"confidence_rate":1},{"cnt":[[146,2419],[1798,2419],[1798,2464],[146,2464]],"region":{"top_left_x":146,"top_left_y":2419,"width":1653,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67e782050951406ca62770a357dd3792","type":"text","conversion_output":true,"text":"suppression. \\({ }^{100}\\) Additional strategies including rapid contractions of the pelvic floor, or quick flicks","text_display":" suppression. \\({ }^{100}\\) Additional strategies including rapid contractions of the pelvic floor, or quick flicks","confidence":1,"confidence_rate":1},{"cnt":[[146,2462],[1833,2462],[1833,2507],[146,2507]],"region":{"top_left_x":146,"top_left_y":2462,"width":1687,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"111b788da78f40cab19424966bccda09","type":"text","conversion_output":true,"text":"(described below) and the use of self-motivating statements (\"I can do it,\" \"I am in control.\") are also","text_display":" (described below) and the use of self-motivating statements (\"I can do it,\" \"I am in control.\") are also","confidence":0.99658203125,"confidence_rate":0.9999685892699369},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28e3136a19854fb8ad5257670c0367ee","type":"page_info","conversion_output":false,"text":"32","text_display":"","confidence":0.99951171875,"confidence_rate":0.9997558295653994},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"335908b5a6524f46b43ea6d068dc827f","type":"page_info","conversion_output":false,"text":"Version 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\\({ }^{104}\\) Furthermore, patients are instructed to avoid running or walking fast to the bathroom as this","text_display":"\npopular. \\({ }^{104}\\) Furthermore, patients are instructed to avoid running or walking fast to the bathroom as this","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1927,305],[1927,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1782,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ca010e765b9402a8786deebb9a7425c","type":"text","conversion_output":true,"text":"may increase intra-abdominal pressure and promote leakage. Bladder training is used to slowly increase","text_display":" may increase intra-abdominal pressure and promote leakage. Bladder training is used to slowly increase","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[1921,348],[1921,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1775,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ce4792cef034a0f9241003bee71486a","type":"text","conversion_output":true,"text":"the interval between voids in attempts of reestablishing normal voiding intervals, break previously formed","text_display":" the interval between voids in attempts of reestablishing normal voiding intervals, break previously formed","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1940,391],[1940,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1795,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a352a921c86f40fe8d23f7f628bcc37c","type":"text","conversion_output":true,"text":"voiding habits, and diminishing urgency. In general, the voiding interval is increased on a weekly basis by","text_display":" voiding habits, and diminishing urgency. In general, the voiding interval is increased on a weekly basis by","confidence":1,"confidence_rate":1},{"cnt":[[146,434],[1876,434],[1876,479],[146,479]],"region":{"top_left_x":146,"top_left_y":433,"width":1730,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"774307e3229141fb8d877b3cfe030062","type":"text","conversion_output":true,"text":"approximately 15 to 30 minutes until a voiding interval of every \\(3-4\\) hours is reached. \\({ }^{104}\\) A randomized","text_display":" approximately 15 to 30 minutes until a voiding interval of every \\(3-4\\) hours is reached. \\({ }^{104}\\) A randomized","confidence":0.99951171875,"confidence_rate":0.9999961543341811},{"cnt":[[146,477],[1878,477],[1878,522],[146,522]],"region":{"top_left_x":146,"top_left_y":476,"width":1732,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"373cf98366444b14928f86b78beba311","type":"text","conversion_output":true,"text":"controlled trial of 123 women with mixed urinary incontinence showed a \\(57 \\%\\) reduction in incontinence","text_display":" controlled trial of 123 women with mixed urinary incontinence showed a \\(57 \\%\\) reduction in incontinence","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[146,520],[1979,520],[1979,569],[146,569]],"region":{"top_left_x":146,"top_left_y":519,"width":1833,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17b90b8a86224e63a7dd9352895e3e09","type":"text","conversion_output":true,"text":"episodes and a \\(54 \\%\\) reduction in quantity of urine loss after implementation of a bladder training program. \\({ }^{105}\\)","text_display":" episodes and a \\(54 \\%\\) reduction in quantity of urine loss after implementation of a bladder training program. \\({ }^{105}\\)","confidence":0.96484375,"confidence_rate":0.9997114198097629},{"cnt":[[146,565],[1946,565],[1946,612],[146,612]],"region":{"top_left_x":146,"top_left_y":565,"width":1801,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5513527fff58448d8c8a91e769f5330e","type":"text","conversion_output":true,"text":"The ICI rated the level of evidence a 1 (based on scant evidence) and the grade of recommendation","text_display":"\nThe ICI rated the level of evidence a 1 (based on scant evidence) and the grade of recommendation","confidence":0.9951226694975048,"confidence_rate":0.9999534366698628},{"cnt":[[146,610],[1528,610],[1528,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1382,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"656fa7894d3540ffa27cc622073c6530","type":"text","conversion_output":true,"text":"an A for the impact of bladder training on reduction in urinary incontinence.","text_display":" an A for the impact of bladder training on reduction in urinary incontinence.","confidence":0.98486328125,"confidence_rate":0.9998140118320272},{"cnt":[[144,739],[1326,739],[1326,788],[144,788]],"region":{"top_left_x":143,"top_left_y":739,"width":1183,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7d6e12957184048999c131bef38c690","type":"section_header","conversion_output":false,"children_ids":["db4591f536064f249912c4b3c35ed37b"],"text":"","text_display":""},{"cnt":[[146,741],[1321,741],[1321,784],[146,784]],"region":{"top_left_x":146,"top_left_y":741,"width":1176,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db4591f536064f249912c4b3c35ed37b","type":"text","conversion_output":true,"parent_id":"c7d6e12957184048999c131bef38c690","text":"5.2.3. What is the evidence for Pelvic Floor Muscle Training (PFMT)?","text_display":"\n\n\\subsection*{5.2.3. What is the evidence for Pelvic Floor Muscle Training (PFMT)?}","confidence":1,"confidence_rate":1},{"cnt":[[271,795],[1953,795],[1953,836],[271,836]],"region":{"top_left_x":270,"top_left_y":794,"width":1683,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24ef82509f3541ab9dcda71424eb33ce","type":"text","conversion_output":true,"text":"A recent Cochrane review titled \"Pelvic floor muscle training versus no treatment, or inactive control","text_display":"\n\nA recent Cochrane review titled \"Pelvic floor muscle training versus no treatment, or inactive control","confidence":1,"confidence_rate":1},{"cnt":[[146,836],[1962,836],[1962,883],[146,883]],"region":{"top_left_x":146,"top_left_y":835,"width":1816,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60f08e608e174f9199a48d294e41c7df","type":"text","conversion_output":true,"text":"treatments, for urinary incontinence in women\" reported on 12 PFMT trials. \\({ }^{20}\\) Of the 12 PFMT trials meeting","text_display":" treatments, for urinary incontinence in women\" reported on 12 PFMT trials. \\({ }^{20}\\) Of the 12 PFMT trials meeting","confidence":0.998535871389322,"confidence_rate":0.9999885531788409},{"cnt":[[146,881],[1938,881],[1938,926],[146,926]],"region":{"top_left_x":146,"top_left_y":880,"width":1792,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70394f755eba4e269c574264d8c7b9d1","type":"text","conversion_output":true,"text":"their inclusion criteria, 3 provided no details of the PFMT method used. Per the review, most existing trials","text_display":" their inclusion criteria, 3 provided no details of the PFMT method used. Per the review, most existing trials","confidence":1,"confidence_rate":1},{"cnt":[[146,924],[1923,924],[1923,971],[146,971]],"region":{"top_left_x":146,"top_left_y":923,"width":1777,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a2eb086d5a942a89162e252f30236e4","type":"text","conversion_output":true,"text":"were at moderate to high risk of bias. There was considerable heterogeneity in interventions used, study","text_display":" were at moderate to high risk of bias. There was considerable heterogeneity in interventions used, study","confidence":1,"confidence_rate":1},{"cnt":[[146,971],[1798,971],[1798,1016],[146,1016]],"region":{"top_left_x":146,"top_left_y":971,"width":1653,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b50b7adb0c9e422599c19947246e2528","type":"text","conversion_output":true,"text":"populations and outcome measures. Women who did PFMT were more likely to report subjective","text_display":" populations and outcome measures. Women who did PFMT were more likely to report subjective","confidence":1,"confidence_rate":1},{"cnt":[[146,1014],[1876,1014],[1876,1059],[146,1059]],"region":{"top_left_x":146,"top_left_y":1014,"width":1730,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b4fb7490000430dbde84fc8519965ca","type":"text","conversion_output":true,"text":"improvement, cure and improvement in quality of life compared to those who did not. Women who did","text_display":" improvement, cure and improvement in quality of life compared to those who did not. Women who did","confidence":1,"confidence_rate":1},{"cnt":[[146,1057],[1944,1057],[1944,1102],[146,1102]],"region":{"top_left_x":146,"top_left_y":1057,"width":1799,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8de2a8f806e24fc398fd7558326bc4ae","type":"text","conversion_output":true,"text":"PFMT also reported fewer incontinence episodes per day, and less leakage on short office based pad test","text_display":" PFMT also reported fewer incontinence episodes per day, and less leakage on short office based pad test","confidence":1,"confidence_rate":1},{"cnt":[[146,1102],[1796,1102],[1796,1145],[146,1145]],"region":{"top_left_x":146,"top_left_y":1102,"width":1651,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a27875fe68c14b588635dca8170ed1c8","type":"text","conversion_output":true,"text":"compared to those that did not. The authors concluded that PFMT should be considered first-line","text_display":" compared to those that did not. The authors concluded that PFMT should be considered first-line","confidence":1,"confidence_rate":1},{"cnt":[[146,1147],[1923,1147],[1923,1190],[146,1190]],"region":{"top_left_x":146,"top_left_y":1147,"width":1777,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f903403d56394fa5b5061ef33a426b6b","type":"text","conversion_output":true,"text":"conservative treatment for SUI, UUI, or MUI. The effect seemed greatest in women with pure SUI and for","text_display":" conservative treatment for SUI, UUI, or MUI. The effect seemed greatest in women with pure SUI and for","confidence":1,"confidence_rate":1},{"cnt":[[146,1190],[1910,1190],[1910,1235],[146,1235]],"region":{"top_left_x":146,"top_left_y":1190,"width":1764,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd1bbd88d677425994c3daa14aca267b","type":"text","conversion_output":true,"text":"programs that were at least 3 month in duration; however the authors recommend additional research to","text_display":" programs that were at least 3 month in duration; however the authors recommend additional research to","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[146,1233],[604,1233],[604,1278],[146,1278]],"region":{"top_left_x":146,"top_left_y":1233,"width":458,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9a38893e6064cd2aa1e316da3248be0","type":"text","conversion_output":true,"text":"support these conclusions.","text_display":" support these conclusions.","confidence":1,"confidence_rate":1},{"cnt":[[142,1360],[1506,1360],[1506,1412],[142,1412]],"region":{"top_left_x":141,"top_left_y":1359,"width":1366,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39d0f8c0db294e688d44b9655460c3bd","type":"section_header","conversion_output":false,"children_ids":["8335b2a730234a9297bf497c62803190"],"text":"","text_display":""},{"cnt":[[146,1362],[1502,1362],[1502,1407],[146,1407]],"region":{"top_left_x":146,"top_left_y":1362,"width":1356,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8335b2a730234a9297bf497c62803190","type":"text","conversion_output":true,"parent_id":"39d0f8c0db294e688d44b9655460c3bd","text":"5.2.4. What is the best approach to PFMT for treatment of urinary incontinence?","text_display":"\n\n\\subsection*{5.2.4. What is the best approach to PFMT for treatment of urinary incontinence?}","confidence":1,"confidence_rate":1},{"cnt":[[271,1416],[1880,1416],[1880,1463],[271,1463]],"region":{"top_left_x":270,"top_left_y":1415,"width":1610,"height":49},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd3fed0c034a40cd90fb6fedcbb37ba9","type":"text","conversion_output":true,"text":"The same Cochrane review \\({ }^{20}\\) above also attempted to separate trials by those that increase: 1)","text_display":"\n\nThe same Cochrane review \\({ }^{20}\\) above also attempted to separate trials by those that increase: 1)","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[146,1461],[1899,1461],[1899,1506],[146,1506]],"region":{"top_left_x":146,"top_left_y":1460,"width":1754,"height":47},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd80c47bc412465e9dd0b28f2aa5ad40","type":"text","conversion_output":true,"text":"Strength 2) Endurance, and/or 3) Coordination (for urgency suppression). Based on the descriptions of","text_display":" Strength 2) Endurance, and/or 3) Coordination (for urgency suppression). Based on the descriptions of","confidence":0.994140625,"confidence_rate":0.9999445618340256},{"cnt":[[146,1504],[1904,1504],[1904,1549],[146,1549]],"region":{"top_left_x":146,"top_left_y":1503,"width":1758,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"014974ab39794bd9b0ec3490eebd3d43","type":"text","conversion_output":true,"text":"training, two trials had PFMT programs that clearly or predominantly targeted coordination \\({ }^{106}\\) or strength","text_display":" training, two trials had PFMT programs that clearly or predominantly targeted coordination \\({ }^{106}\\) or strength","confidence":1,"confidence_rate":1},{"cnt":[[146,1547],[1949,1547],[1949,1594],[146,1594]],"region":{"top_left_x":146,"top_left_y":1546,"width":1803,"height":49},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24483d310b614e82b24195d35f4d49df","type":"text","conversion_output":true,"text":"training \\({ }^{107}\\). Miller and colleagues described a short (one week) program to improve coordination between a","text_display":" training \\({ }^{107}\\). Miller and colleagues described a short (one week) program to improve coordination between a","confidence":0.9990234375,"confidence_rate":0.9999919915103647},{"cnt":[[146,1590],[1846,1590],[1846,1639],[146,1639]],"region":{"top_left_x":146,"top_left_y":1589,"width":1700,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8bf56fe3c944cccaa7653b6a89b075f","type":"text","conversion_output":true,"text":"voluntary pelvic floor muscle contraction (VPFMC) and a rise in intra-abdominal pressure. \\({ }^{106} B \\emptyset\\) et al","text_display":" voluntary pelvic floor muscle contraction (VPFMC) and a rise in intra-abdominal pressure. \\({ }^{106} B \\emptyset\\) et al","confidence":0.541262149810791,"confidence_rate":0.9948548653771424},{"cnt":[[146,1637],[1953,1637],[1953,1682],[146,1682]],"region":{"top_left_x":146,"top_left_y":1637,"width":1807,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b62e6c762392490ebec32d941b7163f5","type":"text","conversion_output":true,"text":"recommended a program that comprised 8 to 12 high intensity (close to maximal) VPFMC, with six to eight","text_display":" recommended a program that comprised 8 to 12 high intensity (close to maximal) VPFMC, with six to eight","confidence":0.9990236759185791,"confidence_rate":0.9999914316069175},{"cnt":[[146,1680],[1884,1680],[1884,1723],[146,1723]],"region":{"top_left_x":146,"top_left_y":1680,"width":1739,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5849e78897a42c38bf1ce65facf03a2","type":"text","conversion_output":true,"text":"second hold and three to four fast contractions added at the end of each hold, six second rest between","text_display":" second hold and three to four fast contractions added at the end of each hold, six second rest between","confidence":1,"confidence_rate":1},{"cnt":[[146,1725],[1931,1725],[1931,1770],[146,1770]],"region":{"top_left_x":146,"top_left_y":1725,"width":1786,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1c211e4f54b4da1845a852a041fe6c8","type":"text","conversion_output":true,"text":"contractions three times per day. Exercises were done in different body positions included lying, kneeling,","text_display":" contractions three times per day. Exercises were done in different body positions included lying, kneeling,","confidence":1,"confidence_rate":1},{"cnt":[[146,1766],[784,1766],[784,1815],[146,1815]],"region":{"top_left_x":146,"top_left_y":1766,"width":639,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dda3695906be478ead25060aaa47e779","type":"text","conversion_output":true,"text":"sitting, standing; all with legs apart \\({ }^{107}\\).","text_display":" sitting, standing; all with legs apart \\({ }^{107}\\).","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[271,1813],[1962,1813],[1962,1858],[271,1858]],"region":{"top_left_x":270,"top_left_y":1813,"width":1692,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5b175741155438abcddc007fb4ce79d","type":"text","conversion_output":true,"text":"It was difficult to characterize the other PFMT programs, because they were either a mixed program","text_display":"\n\nIt was difficult to characterize the other PFMT programs, because they were either a mixed program","confidence":1,"confidence_rate":1},{"cnt":[[146,1856],[1979,1856],[1979,1901],[146,1901]],"region":{"top_left_x":146,"top_left_y":1856,"width":1833,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bb9e53caddc408a9d7bd0095e1e695c","type":"text","conversion_output":true,"text":"(for example strength and endurance) or had not described a key training parameter (for example amount of","text_display":" (for example strength and endurance) or had not described a key training parameter (for example amount of","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[146,1899],[1931,1899],[1931,1944],[146,1944]],"region":{"top_left_x":146,"top_left_y":1899,"width":1786,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5def0b09e95e4c44a7e620118c228d87","type":"text","conversion_output":true,"text":"voluntary effort per contraction). This Cochrane review highlighted some gaps and opportunities for future","text_display":" voluntary effort per contraction). This Cochrane review highlighted some gaps and opportunities for future","confidence":1,"confidence_rate":1},{"cnt":[[146,1944],[1841,1944],[1841,1983],[146,1983]],"region":{"top_left_x":146,"top_left_y":1944,"width":1696,"height":40},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c48aec5be3d495db80f02a5eb283b39","type":"text","conversion_output":true,"text":"research in this field. Recommendations from the authors included research in which one arm would","text_display":" research in this field. Recommendations from the authors included research in which one arm would","confidence":1,"confidence_rate":1},{"cnt":[[146,1987],[1867,1987],[1867,2032],[146,2032]],"region":{"top_left_x":146,"top_left_y":1987,"width":1721,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abd95363190a4d9fb0f4a2018957d800","type":"text","conversion_output":true,"text":"comprise a supervised PFMT program derived from sound exercise science, confirmation of a correct","text_display":" comprise a supervised PFMT program derived from sound exercise science, confirmation of a correct","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[146,2032],[1968,2032],[1968,2078],[146,2078]],"region":{"top_left_x":146,"top_left_y":2032,"width":1822,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c16e6330828464a99139996154a4b45","type":"text","conversion_output":true,"text":"voluntary pelvic floor muscle contraction, and incorporate appropriate supervision and adherence measures","text_display":" voluntary pelvic floor muscle contraction, and incorporate appropriate supervision and adherence measures","confidence":1,"confidence_rate":1},{"cnt":[[146,2075],[1953,2075],[1953,2121],[146,2121]],"region":{"top_left_x":146,"top_left_y":2075,"width":1807,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c75b3c0ae5e7471db8563f2e49d3a1e8","type":"text","conversion_output":true,"text":"to promote maintenance of knowledge acquisition. The choice of program would have to be set against the","text_display":" to promote maintenance of knowledge acquisition. The choice of program would have to be set against the","confidence":1,"confidence_rate":1},{"cnt":[[146,2121],[1968,2121],[1968,2166],[146,2166]],"region":{"top_left_x":146,"top_left_y":2120,"width":1822,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"204b6d18b8e64e129df52f807ad37b26","type":"text","conversion_output":true,"text":"resource implications of intensively supervised individual programs and the opportunity cost this represents.","text_display":" resource implications of intensively supervised individual programs and the opportunity cost this represents.","confidence":1,"confidence_rate":1},{"cnt":[[146,2161],[1936,2161],[1936,2211],[146,2211]],"region":{"top_left_x":146,"top_left_y":2161,"width":1790,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"225b306b5f0c4953a8be803455875370","type":"text","conversion_output":true,"text":"The reporting of formal economic analysis would have to be added to the study. Careful clinical judgment","text_display":" The reporting of formal economic analysis would have to be added to the study. Careful clinical judgment","confidence":1,"confidence_rate":1},{"cnt":[[146,2209],[1957,2209],[1957,2254],[146,2254]],"region":{"top_left_x":146,"top_left_y":2208,"width":1812,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a7be018005d4e42841ac47f2eb6eaa8","type":"text","conversion_output":true,"text":"would be needed about what sort of program could actually be applied in everyday practice and in different","text_display":" would be needed about what sort of program could actually be applied in everyday practice and in different","confidence":1,"confidence_rate":1},{"cnt":[[146,2252],[1876,2252],[1876,2297],[146,2297]],"region":{"top_left_x":146,"top_left_y":2251,"width":1730,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b46886c0c1a241e9ab9cc0fe6a29fbf6","type":"text","conversion_output":true,"text":"countries with their different health care delivery systems while still delivering an effective intervention.","text_display":" countries with their different health care delivery systems while still delivering an effective intervention.","confidence":1,"confidence_rate":1},{"cnt":[[271,2295],[1880,2295],[1880,2340],[271,2340]],"region":{"top_left_x":270,"top_left_y":2294,"width":1610,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59b17f30579e4c648ec623d8d22318c2","type":"text","conversion_output":true,"text":"A second relevant Cochrane review \\({ }^{108}\\) titled \"Comparisons of approaches to pelvic floor muscle","text_display":"\n\nA second relevant Cochrane review \\({ }^{108}\\) titled \"Comparisons of approaches to pelvic floor muscle","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[146,2340],[1815,2340],[1815,2385],[146,2385]],"region":{"top_left_x":146,"top_left_y":2339,"width":1670,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1409fc392bf4c39a0e98b32b6a01262","type":"text","conversion_output":true,"text":"training for urinary incontinence in women\" also attempted to compare different approaches and/or","text_display":" training for urinary incontinence in women\" also attempted to compare different approaches and/or","confidence":1,"confidence_rate":1},{"cnt":[[146,2385],[1904,2385],[1904,2430],[146,2430]],"region":{"top_left_x":146,"top_left_y":2384,"width":1758,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83cebaff18824a4385139b531bb7aa5e","type":"text","conversion_output":true,"text":"components. These included: 1) differences in training supervision (amount, individual versus group), 2)","text_display":" components. These included: 1) differences in training supervision (amount, individual versus group), 2)","confidence":0.99658203125,"confidence_rate":0.9999685892699369},{"cnt":[[146,2428],[1871,2428],[1871,2473],[146,2473]],"region":{"top_left_x":146,"top_left_y":2427,"width":1726,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7187be491a894812bef2905677bdc36e","type":"text","conversion_output":true,"text":"approach (one versus another, the effect of an additional component) and 3) exercise training (type of","text_display":" approach (one versus another, the effect of an additional component) and 3) exercise training (type of","confidence":0.85400390625,"confidence_rate":0.9985261384999985},{"cnt":[[146,2471],[1846,2471],[1846,2516],[146,2516]],"region":{"top_left_x":146,"top_left_y":2470,"width":1700,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc410d71528148a99e9e78d83e33efb1","type":"text","conversion_output":true,"text":"contraction, frequency of training). Overall, the review concluded that there was insufficient evidence","text_display":" contraction, frequency of training). Overall, the review concluded that there was insufficient evidence","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1336e0788c5443f6ba84a6396333a0c0","type":"page_info","conversion_output":false,"text":"33","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"715d8d7ff8394d749ec7e5371743072c","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-34","page":34,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3234158b8884dabaa5dc72ad3edc948","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf2845ec00cc42d395446a2460078be8","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86f058a9e1ff41d4817ebc55a55084ff","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"596c8b10a1c345beaec9b481c898202c","type":"text","conversion_output":true,"text":"Confidential","text_display":"\n\nConfidential","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1841,260],[1841,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1696,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e114bcbbc5bf4315bd4505e27b5c50db","type":"text","conversion_output":true,"text":"regarding the best approach to PFMT; however, more frequent visits resulted in improved subjective","text_display":"\nregarding the best approach to PFMT; however, more frequent visits resulted in improved subjective","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1962,305],[1962,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1816,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad5f194e44d043ac82868e1b406542a7","type":"text","conversion_output":true,"text":"outcomes (women receiving \"regular\" supervision were more likely to report improvement compared to little","text_display":" outcomes (women receiving \"regular\" supervision were more likely to report improvement compared to little","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[466,348],[466,393],[146,393]],"region":{"top_left_x":146,"top_left_y":348,"width":321,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"570d9cc58eb24df1aaa8ff84397162ca","type":"text","conversion_output":true,"text":"or no supervision).","text_display":" or no supervision).","confidence":1,"confidence_rate":1},{"cnt":[[142,473],[1012,473],[1012,522],[142,522]],"region":{"top_left_x":141,"top_left_y":472,"width":871,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"404f04e82e5845909d14dca6c1a3ac59","type":"section_header","conversion_output":false,"children_ids":["06f7a354b4bb4b86ac10bacc38f7e21f"],"text":"","text_display":""},{"cnt":[[146,477],[1008,477],[1008,520],[146,520]],"region":{"top_left_x":146,"top_left_y":476,"width":862,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06f7a354b4bb4b86ac10bacc38f7e21f","type":"text","conversion_output":true,"parent_id":"404f04e82e5845909d14dca6c1a3ac59","text":"5.3. What is the best \"control\" group for this study?","text_display":"\n\n\\subsection*{5.3. 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Educational materials that are routinely","text_display":" educational materials about behavioral and/or pelvic floor therapy. Educational materials that are routinely","confidence":1,"confidence_rate":1},{"cnt":[[146,619],[1884,619],[1884,664],[146,664]],"region":{"top_left_x":146,"top_left_y":618,"width":1739,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4773a3f0838e4fb28e0b9cc362863159","type":"text","conversion_output":true,"text":"provided to women with MUI considering treatment options (before deciding on surgery) from each site","text_display":" provided to women with MUI considering treatment options (before deciding on surgery) from each site","confidence":1,"confidence_rate":1},{"cnt":[[146,662],[1777,662],[1777,707],[146,707]],"region":{"top_left_x":146,"top_left_y":661,"width":1631,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc95ffd32e1545f182db7980b89aa646","type":"text","conversion_output":true,"text":"were collected. The majority of sites (7/8) currently provide routine written material to patients on","text_display":" were collected. The majority of sites (7/8) currently provide routine written material to patients on","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[146,707],[1772,707],[1772,750],[146,750]],"region":{"top_left_x":146,"top_left_y":706,"width":1627,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"839f549ff9b54c079b318c63a93ef8e3","type":"text","conversion_output":true,"text":"Kegel's/pelvic floor muscle exercises. The majority also routinely provide information on: 1) urge","text_display":" Kegel's/pelvic floor muscle exercises. The majority also routinely provide information on: 1) urge","confidence":0.69921875,"confidence_rate":0.9965323211045856},{"cnt":[[146,752],[1876,752],[1876,795],[146,795]],"region":{"top_left_x":146,"top_left_y":751,"width":1730,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3c2448050584e36847b730f5c287d78","type":"text","conversion_output":true,"text":"suppression/kegel (7/8 sites); caffeine (7/8 sites); other bladder irritants (5/8 sites), and excessive fluid","text_display":" suppression/kegel (7/8 sites); caffeine (7/8 sites); other bladder irritants (5/8 sites), and excessive fluid","confidence":0.6466314061641637,"confidence_rate":0.9961829277903459},{"cnt":[[146,795],[1880,795],[1880,838],[146,838]],"region":{"top_left_x":146,"top_left_y":794,"width":1734,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b922828708d640b0bb5d80a915fa70c2","type":"text","conversion_output":true,"text":"intake ( \\(6 / 8\\) sites). All sites were in agreement that these are routinely offered to women prior to moving","text_display":" intake ( \\(6 / 8\\) sites). All sites were in agreement that these are routinely offered to women prior to moving","confidence":0.9970703125,"confidence_rate":0.9999742635993027},{"cnt":[[146,838],[1846,838],[1846,883],[146,883]],"region":{"top_left_x":146,"top_left_y":837,"width":1700,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c29b8240bc9c4ba5a5f927ec2262aada","type":"text","conversion_output":true,"text":"forward with surgical intervention, although not all women choose to use these behavioral strategies.","text_display":" forward with surgical intervention, although not all women choose to use these behavioral strategies.","confidence":1,"confidence_rate":1},{"cnt":[[271,885],[1826,885],[1826,926],[271,926]],"region":{"top_left_x":270,"top_left_y":885,"width":1557,"height":41},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"805184a1b837480b87e871fb8db95f73","type":"text","conversion_output":true,"text":"The team considered the possibility of providing educational pamphlets to the control group;","text_display":"\n\nThe team considered the possibility of providing educational pamphlets to the control group;","confidence":1,"confidence_rate":1},{"cnt":[[146,928],[1914,928],[1914,969],[146,969]],"region":{"top_left_x":146,"top_left_y":928,"width":1769,"height":41},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85b8e4fa600c402e95c0d444adec1160","type":"text","conversion_output":true,"text":"however, the ESTEEM population includes women who have already elected to proceed with surgery. In","text_display":" however, the ESTEEM population includes women who have already elected to proceed with surgery. In","confidence":1,"confidence_rate":1},{"cnt":[[146,971],[1979,971],[1979,1016],[146,1016]],"region":{"top_left_x":146,"top_left_y":971,"width":1833,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9df5e80e8df34032940597f53a4b49c0","type":"text","conversion_output":true,"text":"clinical practice, women who have decided on surgery have already been offered other conservative options","text_display":" clinical practice, women who have decided on surgery have already been offered other conservative options","confidence":1,"confidence_rate":1},{"cnt":[[146,1016],[1807,1016],[1807,1059],[146,1059]],"region":{"top_left_x":146,"top_left_y":1016,"width":1661,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3690f56953344d0b8d5621336524029e","type":"text","conversion_output":true,"text":"and it is not routine practice to provide pamphlets again about other options at a preoperative visit.","text_display":" and it is not routine practice to provide pamphlets again about other options at a preoperative visit.","confidence":1,"confidence_rate":1},{"cnt":[[146,1057],[1244,1057],[1244,1102],[146,1102]],"region":{"top_left_x":146,"top_left_y":1057,"width":1098,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"045cdc77cd8a42a88b15070cc04054c3","type":"text","conversion_output":true,"text":"Therefore, this would not mirror what happens in the \"real world\".","text_display":" Therefore, this would not mirror what happens in the \"real world\".","confidence":1,"confidence_rate":1},{"cnt":[[271,1104],[1884,1104],[1884,1145],[271,1145]],"region":{"top_left_x":270,"top_left_y":1104,"width":1615,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0314558f950b4559846307b2fab37dd4","type":"text","conversion_output":true,"text":"Because of these reasons, the team agreed the control group in ESTEEM should be MUS only.","text_display":"\n\nBecause of these reasons, the team agreed the control group in ESTEEM should be MUS only.","confidence":1,"confidence_rate":1},{"cnt":[[148,1147],[1944,1147],[1944,1190],[148,1190]],"region":{"top_left_x":148,"top_left_y":1147,"width":1797,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9f008961c2b4150b8b6de24a341ce58","type":"text","conversion_output":true,"text":"However to balance this, as part of our inclusion criteria, women will be reminded that BPTx is a treatment","text_display":" However to balance this, as part of our inclusion criteria, women will be reminded that BPTx is a treatment","confidence":1,"confidence_rate":1},{"cnt":[[146,1190],[1869,1190],[1869,1233],[146,1233]],"region":{"top_left_x":146,"top_left_y":1190,"width":1724,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"149bd67cf15e48b8ad5bd92d32f63e58","type":"text","conversion_output":true,"text":"option for MUI (even outside of the study) to ensure they have been offered behavioral therapy and/or","text_display":" option for MUI (even outside of the study) to ensure they have been offered behavioral therapy and/or","confidence":1,"confidence_rate":1},{"cnt":[[146,1233],[1931,1233],[1931,1278],[146,1278]],"region":{"top_left_x":146,"top_left_y":1233,"width":1786,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f586bbed527444bb36e677bfbffbe49","type":"text","conversion_output":true,"text":"physical therapy outside of ESTEEM. (See Inclusion Criteria, Section 4.2). Along these lines, women who","text_display":" physical therapy outside of ESTEEM. (See Inclusion Criteria, Section 4.2). Along these lines, women who","confidence":1,"confidence_rate":1},{"cnt":[[146,1278],[1886,1278],[1886,1321],[146,1321]],"region":{"top_left_x":146,"top_left_y":1278,"width":1741,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20ec29e3a96141c9a76e48e3878db4ef","type":"text","conversion_output":true,"text":"previously tried other behavioral or pelvic therapy will not be excluded. If the patient meets eligibility for","text_display":" previously tried other behavioral or pelvic therapy will not be excluded. If the patient meets eligibility for","confidence":1,"confidence_rate":1},{"cnt":[[146,1319],[1854,1319],[1854,1364],[146,1364]],"region":{"top_left_x":146,"top_left_y":1319,"width":1709,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ba371f86f0a481c88082130c5250045","type":"text","conversion_output":true,"text":"ESTEEM, she would still have bothersome MUI by inclusion criteria. If the patient was not aware that","text_display":" ESTEEM, she would still have bothersome MUI by inclusion criteria. If the patient was not aware that","confidence":1,"confidence_rate":1},{"cnt":[[146,1366],[1919,1366],[1919,1412],[146,1412]],"region":{"top_left_x":146,"top_left_y":1366,"width":1773,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78b499caea7a4731b1d5993db9ccbe8d","type":"text","conversion_output":true,"text":"behavioral/physical therapy was an option, she would be offered a referral at that point for which she can","text_display":" behavioral/physical therapy was an option, she would be offered a referral at that point for which she can","confidence":1,"confidence_rate":1},{"cnt":[[146,1409],[1798,1409],[1798,1454],[146,1454]],"region":{"top_left_x":146,"top_left_y":1409,"width":1653,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a3126d0ee704e479863df5d92fff8ec","type":"text","conversion_output":true,"text":"either accept (and cancel her surgery), or decline (and still be eligible for ESTEEM). The research","text_display":" either accept (and cancel her surgery), or decline (and still be eligible for ESTEEM). The research","confidence":1,"confidence_rate":1},{"cnt":[[146,1452],[1888,1452],[1888,1497],[146,1497]],"region":{"top_left_x":146,"top_left_y":1452,"width":1743,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2f3c2f2dc49429ca5274b1b26ef9898","type":"text","conversion_output":true,"text":"coordinator will ask this screening question using similar wording that has been used in previous PFDN","text_display":" coordinator will ask this screening question using similar wording that has been used in previous PFDN","confidence":1,"confidence_rate":1},{"cnt":[[146,1500],[316,1500],[316,1540],[146,1540]],"region":{"top_left_x":146,"top_left_y":1499,"width":170,"height":42},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2a8b17f65fe4ca5be5b257f4652d3e2","type":"text","conversion_output":true,"text":"protocols.","text_display":" protocols.","confidence":1,"confidence_rate":1},{"cnt":[[271,1543],[1910,1543],[1910,1586],[271,1586]],"region":{"top_left_x":270,"top_left_y":1542,"width":1640,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f5d77a25d3345518546ba6a77a12ea6","type":"text","conversion_output":true,"text":"Although routine educational pamphlets may be provided to subjects prior to their enrollment into","text_display":"\n\nAlthough routine educational pamphlets may be provided to subjects prior to their enrollment into","confidence":1,"confidence_rate":1},{"cnt":[[146,1586],[1940,1586],[1940,1629],[146,1629]],"region":{"top_left_x":146,"top_left_y":1585,"width":1795,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47bc7bcf4230441bbf9f8bbcba259f10","type":"text","conversion_output":true,"text":"ESTEEM per usual care at each site, once enrolled, no additional educational pamphlets may be provided","text_display":" ESTEEM per usual care at each site, once enrolled, no additional educational pamphlets may be provided","confidence":1,"confidence_rate":1},{"cnt":[[146,1629],[1893,1629],[1893,1674],[146,1674]],"region":{"top_left_x":146,"top_left_y":1628,"width":1747,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f31811a20d74c6eb0097d4b8cb28667","type":"text","conversion_output":true,"text":"to either control or intervention subjects outside of the protocol. The control group will complete bladder","text_display":" to either control or intervention subjects outside of the protocol. The control group will complete bladder","confidence":1,"confidence_rate":1},{"cnt":[[146,1676],[1914,1676],[1914,1717],[146,1717]],"region":{"top_left_x":146,"top_left_y":1675,"width":1769,"height":42},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66e803147f834370a382e16c4548c7ac","type":"text","conversion_output":true,"text":"diaries and undergo PFM assessments at the same time intervals as the intervention group to control for","text_display":" diaries and undergo PFM assessments at the same time intervals as the intervention group to control for","confidence":1,"confidence_rate":1},{"cnt":[[146,1714],[1399,1714],[1399,1760],[146,1760]],"region":{"top_left_x":146,"top_left_y":1714,"width":1253,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5f37d46ae7445e39cfe3f95ffdff80d","type":"text","conversion_output":true,"text":"any potential independent effects that bladder diary completion may have.","text_display":" any potential independent effects that bladder diary completion may have.","confidence":1,"confidence_rate":1},{"cnt":[[146,1805],[1708,1805],[1708,1850],[146,1850]],"region":{"top_left_x":146,"top_left_y":1804,"width":1563,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"214338e7d3714f698e21fed3198f04c9","type":"text","conversion_output":true,"text":"Rationale for including women who have previously tried behavioral and/or physical therapy:","text_display":"\n\nRationale for including women who have previously tried behavioral and/or physical therapy:","confidence":1,"confidence_rate":1},{"cnt":[[271,1848],[1944,1848],[1944,1893],[271,1893]],"region":{"top_left_x":270,"top_left_y":1847,"width":1675,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"081474767bee43c09cb78a61e7e2e384","type":"text","conversion_output":true,"text":"There are many reasons to include women who have previously tried behavioral and/or pelvic floor","text_display":"\nThere are many reasons to include women who have previously tried behavioral and/or pelvic floor","confidence":1,"confidence_rate":1},{"cnt":[[146,1893],[1910,1893],[1910,1936],[146,1936]],"region":{"top_left_x":146,"top_left_y":1892,"width":1764,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a8d474d049043ab9105a0315e20a225","type":"text","conversion_output":true,"text":"physical therapy. First, women eligible for ESTEEM must have at least moderately bothersome MUI and","text_display":" physical therapy. First, women eligible for ESTEEM must have at least moderately bothersome MUI and","confidence":1,"confidence_rate":1},{"cnt":[[146,1938],[1949,1938],[1949,1981],[146,1981]],"region":{"top_left_x":146,"top_left_y":1937,"width":1803,"height":44},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f205bfe9565549779267977069a6a77a","type":"text","conversion_output":true,"text":"desire surgery; therefore, even though these women have had treatments in the past, they did not improve","text_display":" desire surgery; therefore, even though these women have had treatments in the past, they did not improve","confidence":1,"confidence_rate":1},{"cnt":[[146,1981],[1949,1981],[1949,2024],[146,2024]],"region":{"top_left_x":146,"top_left_y":1980,"width":1803,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"120e2a75f20e409ebb75887b61a6cba0","type":"text","conversion_output":true,"text":"enough to forego additional treatment. In addition, ESTEEM is evaluating the effect of combined surgical","text_display":" enough to forego additional treatment. In addition, ESTEEM is evaluating the effect of combined surgical","confidence":0.99755859375,"confidence_rate":0.9999775746428119},{"cnt":[[146,2024],[1955,2024],[1955,2069],[146,2069]],"region":{"top_left_x":146,"top_left_y":2023,"width":1810,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f97e489322dd46ae893c33da3a03540b","type":"text","conversion_output":true,"text":"and BPTx treatment and not just BPTx alone. Therefore, women who have previously failed BPTx alone","text_display":" and BPTx treatment and not just BPTx alone. Therefore, women who have previously failed BPTx alone","confidence":1,"confidence_rate":1},{"cnt":[[146,2069],[1962,2069],[1962,2112],[146,2112]],"region":{"top_left_x":146,"top_left_y":2068,"width":1816,"height":44},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b979e7da30245c1b69454d63a1d19ae","type":"text","conversion_output":true,"text":"in the past may still significantly improve with combined surgical/BPTx treatment or surgery alone and there","text_display":" in the past may still significantly improve with combined surgical/BPTx treatment or surgery alone and there","confidence":1,"confidence_rate":1},{"cnt":[[146,2114],[1962,2114],[1962,2155],[146,2155]],"region":{"top_left_x":146,"top_left_y":2114,"width":1816,"height":41},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd15ea3c6a784b93bf9c0f698e733eed","type":"text","conversion_output":true,"text":"is no evidence to support their exclusion from this trial. This is the most important reason why these women","text_display":" is no evidence to support their exclusion from this trial. This is the most important reason why these women","confidence":1,"confidence_rate":1},{"cnt":[[146,2157],[1906,2157],[1906,2198],[146,2198]],"region":{"top_left_x":146,"top_left_y":2157,"width":1760,"height":41},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bb6414214654e11a0ddfb254aa60669","type":"text","conversion_output":true,"text":"should be included. Second, many women who have previously tried behavioral and/or physical therapy","text_display":" should be included. Second, many women who have previously tried behavioral and/or physical therapy","confidence":1,"confidence_rate":1},{"cnt":[[146,2200],[1863,2200],[1863,2243],[146,2243]],"region":{"top_left_x":146,"top_left_y":2200,"width":1717,"height":43},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56791061a733415088f7e6d49360f706","type":"text","conversion_output":true,"text":"may have had a wide range of non-standardized interventions to varying degrees, durations, and with","text_display":" may have had a wide range of non-standardized interventions to varying degrees, durations, and with","confidence":1,"confidence_rate":1},{"cnt":[[146,2243],[1944,2243],[1944,2288],[146,2288]],"region":{"top_left_x":146,"top_left_y":2242,"width":1799,"height":47},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6202861ff904c4cbbfb1c7d001dd9ac","type":"text","conversion_output":true,"text":"various components. Therefore, it is difficult to conclude that they may be at \"higher risk\" for failure, or that","text_display":" various components. Therefore, it is difficult to conclude that they may be at \"higher risk\" for failure, or that","confidence":1,"confidence_rate":1},{"cnt":[[146,2288],[1895,2288],[1895,2331],[146,2331]],"region":{"top_left_x":146,"top_left_y":2288,"width":1749,"height":44},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d0aee9fa4b141fb81f1fa6e7ba52a80","type":"text","conversion_output":true,"text":"they will not benefit from the ESTEEM intervention. In ESTEEM, the BPTx protocol is based on existing","text_display":" they will not benefit from the ESTEEM intervention. In ESTEEM, the BPTx protocol is based on existing","confidence":1,"confidence_rate":1},{"cnt":[[146,2333],[1914,2333],[1914,2374],[146,2374]],"region":{"top_left_x":146,"top_left_y":2333,"width":1769,"height":42},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64a7d67142b543c4a62ee4bdc7fa3004","type":"text","conversion_output":true,"text":"evidence for specific BPTx components and the expertise of interventionists focused solely on improving","text_display":" evidence for specific BPTx components and the expertise of interventionists focused solely on improving","confidence":1,"confidence_rate":1},{"cnt":[[148,2376],[1974,2376],[1974,2419],[148,2419]],"region":{"top_left_x":148,"top_left_y":2376,"width":1827,"height":44},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8a01dbc0d2d4dbda1cbb110b780c1af","type":"text","conversion_output":true,"text":"MUI symptoms. This standardized protocol can potentially enhance the surgical effects for women with MUI.","text_display":" MUI symptoms. This standardized protocol can potentially enhance the surgical effects for women with MUI.","confidence":0.99853515625,"confidence_rate":0.9999866735644114},{"cnt":[[146,2419],[1807,2419],[1807,2464],[146,2464]],"region":{"top_left_x":146,"top_left_y":2419,"width":1661,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf55064bf68b4dc4802c1d9f7f990842","type":"text","conversion_output":true,"text":"The protocol does provide the opportunity to identify risk factors for failure of a standardized BPTx","text_display":" The protocol does provide the opportunity to identify risk factors for failure of a standardized BPTx","confidence":1,"confidence_rate":1},{"cnt":[[146,2462],[1296,2462],[1296,2507],[146,2507]],"region":{"top_left_x":146,"top_left_y":2462,"width":1150,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f84d73394cfd4e9f812b2eba72f7fdd4","type":"text","conversion_output":true,"text":"intervention which will help build additional evidence for future trials.","text_display":" intervention which will help build additional evidence for future trials.","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2e77d230add40ba8888001ec2d0dfdf","type":"page_info","conversion_output":false,"text":"34","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"984ad8377d8243b5a938d18918d7eb45","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-35","page":35,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a68460d11c94741b92a8aced35e8abd","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"637fc320b37f4bdc8de2fdf76e227242","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73619418b9044a8bae4c7281d25fc167","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51dda31ca9074ea29d4198ef5cc6ec0a","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[142,301],[1386,301],[1386,350],[142,350]],"region":{"top_left_x":141,"top_left_y":300,"width":1245,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac8ccadbf2104bd88da589d07951c59d","type":"section_header","conversion_output":false,"children_ids":["86800f2d21b643c1a5388a55845113a8"],"text":"","text_display":""},{"cnt":[[146,305],[1381,305],[1381,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1236,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86800f2d21b643c1a5388a55845113a8","type":"text","conversion_output":true,"parent_id":"ac8ccadbf2104bd88da589d07951c59d","text":"5.4. Intervention - See Appendix A for the full BPTx Intervention Protocol","text_display":"\n\n\\subsection*{5.4. Intervention - See Appendix A for the full BPTx Intervention Protocol}","confidence":0.99951171875,"confidence_rate":0.999993817734324},{"cnt":[[146,348],[1966,348],[1966,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1820,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4b67c7eac2242058002ce206fe81245","type":"text","conversion_output":true,"text":"As stated above, for the intervention the team focused on evidence-based BPTx strategies. When evidence","text_display":"\n\nAs stated above, for the intervention the team focused on evidence-based BPTx strategies. When evidence","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1914,391],[1914,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1769,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c8f7f16b0234e919384a822f00a08b2","type":"text","conversion_output":true,"text":"was lacking, the team made decisions based on the most logical and pragmatic rationale with a focus on","text_display":" was lacking, the team made decisions based on the most logical and pragmatic rationale with a focus on","confidence":1,"confidence_rate":1},{"cnt":[[146,434],[1051,434],[1051,479],[146,479]],"region":{"top_left_x":146,"top_left_y":433,"width":905,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e83c826c71734e8294b52687a32ad382","type":"text","conversion_output":true,"text":"developing a reproducible and standardized protocol.","text_display":" developing a reproducible and standardized protocol.","confidence":1,"confidence_rate":1},{"cnt":[[271,563],[1523,563],[1523,612],[271,612]],"region":{"top_left_x":270,"top_left_y":562,"width":1254,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5edbf12c38714af5bb840debbf1da17d","type":"text","conversion_output":true,"text":"For the purposes of this proposal \"Behavioral training\" (BPTx) will include:","text_display":"\n\nFor the purposes of this proposal \"Behavioral training\" (BPTx) will include:","confidence":1,"confidence_rate":1},{"cnt":[[271,610],[776,610],[776,655],[271,655]],"region":{"top_left_x":270,"top_left_y":610,"width":506,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ee3380bcda74d5d91df490050d22537","type":"text","conversion_output":true,"text":"1. Pelvic floor muscle training","text_display":"\n1. Pelvic floor muscle training","confidence":1,"confidence_rate":1},{"cnt":[[271,653],[1476,653],[1476,698],[271,698]],"region":{"top_left_x":270,"top_left_y":653,"width":1206,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ab991a9a04f48cdafd789ce2b3af56b","type":"text","conversion_output":true,"text":"2. Urge strategies defined in the field (included in intervention handout)","text_display":"\n2. Urge strategies defined in the field (included in intervention handout)","confidence":1,"confidence_rate":1},{"cnt":[[271,696],[1502,696],[1502,743],[271,743]],"region":{"top_left_x":270,"top_left_y":696,"width":1232,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e7c5bb0d54145b38cc0578d4579f8ee","type":"text","conversion_output":true,"text":"3. Stress strategies defined in the field (included in intervention handout)","text_display":"\n3. Stress strategies defined in the field (included in intervention handout)","confidence":1,"confidence_rate":1},{"cnt":[[271,743],[1364,743],[1364,788],[271,788]],"region":{"top_left_x":270,"top_left_y":743,"width":1095,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88df26e644f14f6ea675c750ab63efcd","type":"text","conversion_output":true,"text":"4. Delayed voiding techniques (included in intervention handout)","text_display":"\n4. Delayed voiding techniques (included in intervention handout)","confidence":1,"confidence_rate":1},{"cnt":[[146,829],[1972,829],[1972,874],[146,874]],"region":{"top_left_x":146,"top_left_y":829,"width":1827,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36b4cec27cd24cef991989e64af6b99e","type":"text","conversion_output":true,"text":"The intervention will include 1 preoperative BPTx intervention visit and 5 post-operative intervention visits at","text_display":"\n\nThe intervention will include 1 preoperative BPTx intervention visit and 5 post-operative intervention visits at","confidence":1,"confidence_rate":1},{"cnt":[[146,872],[1944,872],[1944,917],[146,917]],"region":{"top_left_x":146,"top_left_y":872,"width":1799,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"113856cdf33e453aa2b503b8c7a838ac","type":"text","conversion_output":true,"text":"\\(2,4,6\\) and 8 weeks and 6 months postoperative. Data from the ATLAS trial demonstrated that adherence","text_display":" \\(2,4,6\\) and 8 weeks and 6 months postoperative. Data from the ATLAS trial demonstrated that adherence","confidence":0.9005424715950072,"confidence_rate":0.9990393795720538},{"cnt":[[146,915],[1824,915],[1824,965],[146,965]],"region":{"top_left_x":146,"top_left_y":915,"width":1679,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8547cb7ef4374875a08c9e82af2670e2","type":"text","conversion_output":true,"text":"with BPTx strategies decreased after 6 months, corresponding to a potential decrease in benefit. \\({ }^{110}\\)","text_display":" with BPTx strategies decreased after 6 months, corresponding to a potential decrease in benefit. \\({ }^{110}\\)","confidence":1,"confidence_rate":1},{"cnt":[[146,958],[1820,958],[1820,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":958,"width":1674,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fbac1b301e74b58a5f418f9ba868219","type":"text","conversion_output":true,"text":"Therefore, a 6 month BPTx intervention session is part of the intervention in ESTEEM. Participants","text_display":" Therefore, a 6 month BPTx intervention session is part of the intervention in ESTEEM. Participants","confidence":1,"confidence_rate":1},{"cnt":[[146,1005],[1858,1005],[1858,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1005,"width":1713,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2965157978964b88a1ceee23f26c56f4","type":"text","conversion_output":true,"text":"randomized to intervention will receive BPTx implemented by an experienced registered nurse, nurse","text_display":" randomized to intervention will receive BPTx implemented by an experienced registered nurse, nurse","confidence":1,"confidence_rate":1},{"cnt":[[146,1048],[1745,1048],[1745,1096],[146,1096]],"region":{"top_left_x":146,"top_left_y":1048,"width":1599,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"449ff8e393cf4235a60da8926f01cbe6","type":"text","conversion_output":true,"text":"practitioner or physical therapist. Patients will be monitored using an adherence questionnaire.","text_display":" practitioner or physical therapist. Patients will be monitored using an adherence questionnaire.","confidence":1,"confidence_rate":1},{"cnt":[[271,1137],[1515,1137],[1515,1182],[271,1182]],"region":{"top_left_x":270,"top_left_y":1136,"width":1245,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23c2cb0c587c43b7b90653fce113a4a7","type":"text","conversion_output":true,"text":"The intervention will be standardized through the following mechanisms:","text_display":"\n\nThe intervention will be standardized through the following mechanisms:","confidence":1,"confidence_rate":1},{"cnt":[[271,1182],[1888,1182],[1888,1227],[271,1227]],"region":{"top_left_x":270,"top_left_y":1181,"width":1619,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd7824b2c0324d88acf04cbbf543ca67","type":"text","conversion_output":true,"text":"a. Certification of all interventionists through passing of e-learning modules and attendance and","text_display":"\na. Certification of all interventionists through passing of e-learning modules and attendance and","confidence":1,"confidence_rate":1},{"cnt":[[271,1225],[1710,1225],[1710,1270],[271,1270]],"region":{"top_left_x":270,"top_left_y":1224,"width":1441,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a19c7e8552140658ad09de020189869","type":"text","conversion_output":true,"text":"demonstration of hands-on skills at a 2 -day, in-person interventionist training session","text_display":" demonstration of hands-on skills at a 2 -day, in-person interventionist training session","confidence":0.9594922065734863,"confidence_rate":0.9995693522767117},{"cnt":[[271,1268],[1923,1268],[1923,1315],[271,1315]],"region":{"top_left_x":270,"top_left_y":1267,"width":1653,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc062563416a429fa128dc9e79333725","type":"text","conversion_output":true,"text":"b. There will be an interventionist checklist to ensure the same components have been performed","text_display":"\nb. There will be an interventionist checklist to ensure the same components have been performed","confidence":1,"confidence_rate":1},{"cnt":[[271,1315],[544,1315],[544,1360],[271,1360]],"region":{"top_left_x":270,"top_left_y":1314,"width":274,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4b69e745ccc42d98ce59483d21096e1","type":"text","conversion_output":true,"text":"across subjects","text_display":" across subjects","confidence":1,"confidence_rate":1},{"cnt":[[271,1358],[1351,1358],[1351,1403],[271,1403]],"region":{"top_left_x":270,"top_left_y":1357,"width":1082,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2955006a4fba47ba8d19ba49ed401c76","type":"text","conversion_output":true,"text":"c. There is a detailed protocol for the PFM exercise progression","text_display":"\nc. There is a detailed protocol for the PFM exercise progression","confidence":1,"confidence_rate":1},{"cnt":[[271,1401],[1871,1401],[1871,1446],[271,1446]],"region":{"top_left_x":270,"top_left_y":1400,"width":1602,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05cf4cd0e1ba4b1fad2360f6dadd6bea","type":"text","conversion_output":true,"text":"d. There is a detailed protocol for \"special circumstances\" for when the standard PFM exercise","text_display":"\nd. There is a detailed protocol for \"special circumstances\" for when the standard PFM exercise","confidence":1,"confidence_rate":1},{"cnt":[[271,1444],[1955,1444],[1955,1491],[271,1491]],"region":{"top_left_x":270,"top_left_y":1443,"width":1686,"height":49},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e2fdac6947542a9a295acfb7fff3ba4","type":"text","conversion_output":true,"text":"progression protocol cannot be followed (ie: weak muscle) that the interventionist will be required to","text_display":" progression protocol cannot be followed (ie: weak muscle) that the interventionist will be required to","confidence":1,"confidence_rate":1},{"cnt":[[271,1491],[376,1491],[376,1532],[271,1532]],"region":{"top_left_x":270,"top_left_y":1491,"width":106,"height":41},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2aa7145eeb67490c8770f2d5f8cdd241","type":"text","conversion_output":true,"text":"follow","text_display":" follow","confidence":1,"confidence_rate":1},{"cnt":[[271,1534],[1824,1534],[1824,1579],[271,1579]],"region":{"top_left_x":270,"top_left_y":1533,"width":1555,"height":47},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbe86eb844154532b19019aff04da134","type":"text","conversion_output":true,"text":"e. Subject handouts will be developed for the 4 components (PFME, Urge strategies, stress","text_display":"\ne. Subject handouts will be developed for the 4 components (PFME, Urge strategies, stress","confidence":1,"confidence_rate":1},{"cnt":[[271,1577],[1938,1577],[1938,1622],[271,1622]],"region":{"top_left_x":270,"top_left_y":1576,"width":1668,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e171f38462d447e898d436e294a8250","type":"text","conversion_output":true,"text":"strategies, and delayed voiding techniques) and the interventionists will be required to refer only to","text_display":" strategies, and delayed voiding techniques) and the interventionists will be required to refer only to","confidence":1,"confidence_rate":1},{"cnt":[[271,1620],[1057,1620],[1057,1665],[271,1665]],"region":{"top_left_x":270,"top_left_y":1619,"width":788,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26e6402a28de4f10a9df02a3bbc4dc40","type":"text","conversion_output":true,"text":"the handouts during the education component","text_display":" the handouts during the education component","confidence":1,"confidence_rate":1},{"cnt":[[271,1663],[1895,1663],[1895,1708],[271,1708]],"region":{"top_left_x":270,"top_left_y":1662,"width":1625,"height":47},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52bf39dcd6f340c4935e45bd5151c7d3","type":"text","conversion_output":true,"text":"f. All intervention sessions will be audiotaped and a subset will be audited by behavioral therapy","text_display":"\nf. All intervention sessions will be audiotaped and a subset will be audited by behavioral therapy","confidence":0.7956254482269287,"confidence_rate":0.9977827845130179},{"cnt":[[271,1708],[1919,1708],[1919,1755],[271,1755]],"region":{"top_left_x":270,"top_left_y":1708,"width":1649,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bea8965d98a4cf4a9ac7be187b4615f","type":"text","conversion_output":true,"text":"experts to ensure adherence to protocol. Any protocol deviations will be addressed as necessary.","text_display":" experts to ensure adherence to protocol. Any protocol deviations will be addressed as necessary.","confidence":1,"confidence_rate":1},{"cnt":[[271,1753],[1944,1753],[1944,1798],[271,1798]],"region":{"top_left_x":270,"top_left_y":1753,"width":1675,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b37ac1265bd542f489856bcedabadf4b","type":"text","conversion_output":true,"text":"g . Phone calls between interventionists and behavioral experts will take place as needed to ensure","text_display":"\ng . Phone calls between interventionists and behavioral experts will take place as needed to ensure","confidence":0.97265625,"confidence_rate":0.9997384818620685},{"cnt":[[271,1796],[1326,1796],[1326,1841],[271,1841]],"region":{"top_left_x":270,"top_left_y":1796,"width":1056,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"017132bd62f149a2950fdf809f60cc32","type":"text","conversion_output":true,"text":"adherence to protocol and address any issues and deviations.","text_display":" adherence to protocol and address any issues and deviations.","confidence":1,"confidence_rate":1},{"cnt":[[271,1882],[1863,1882],[1863,1929],[271,1929]],"region":{"top_left_x":270,"top_left_y":1882,"width":1593,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88936e8bc03040cea1032374c903e742","type":"text","conversion_output":true,"text":"Preliminary data from the OPTIMAL trial suggest that perioperative BPTx was not effective for","text_display":"\n\nPreliminary data from the OPTIMAL trial suggest that perioperative BPTx was not effective for","confidence":1,"confidence_rate":1},{"cnt":[[146,1927],[1910,1927],[1910,1974],[146,1974]],"region":{"top_left_x":146,"top_left_y":1927,"width":1764,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74926f110ffb4235b777278bcb07a735","type":"text","conversion_output":true,"text":"improving urinary, prolapse, or colorectal symptoms at 6 months (unpublished data); however, the study","text_display":" improving urinary, prolapse, or colorectal symptoms at 6 months (unpublished data); however, the study","confidence":1,"confidence_rate":1},{"cnt":[[146,1972],[1869,1972],[1869,2017],[146,2017]],"region":{"top_left_x":146,"top_left_y":1972,"width":1724,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb9a5d2b93ba4508945e133ecf512d64","type":"text","conversion_output":true,"text":"population in OPTIMAL is significantly different from ESTEEM. Regarding baseline urinary symptoms,","text_display":" population in OPTIMAL is significantly different from ESTEEM. Regarding baseline urinary symptoms,","confidence":1,"confidence_rate":1},{"cnt":[[146,2015],[1848,2015],[1848,2060],[146,2060]],"region":{"top_left_x":146,"top_left_y":2015,"width":1702,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"368fd30b83904d3cb87b030532c70fa7","type":"text","conversion_output":true,"text":"subjects in OPTIMAL were required to have an affirmative response to one SUI item only on the UDI","text_display":" subjects in OPTIMAL were required to have an affirmative response to one SUI item only on the UDI","confidence":1,"confidence_rate":1},{"cnt":[[146,2058],[1882,2058],[1882,2103],[146,2103]],"region":{"top_left_x":146,"top_left_y":2058,"width":1737,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43c2059dc061441c9e456283574d4a41","type":"text","conversion_output":true,"text":"whereas subjects in ESTEEM will be required to have an affirmative response to both the SUI and UUI","text_display":" whereas subjects in ESTEEM will be required to have an affirmative response to both the SUI and UUI","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[146,2101],[1962,2101],[1962,2151],[146,2151]],"region":{"top_left_x":146,"top_left_y":2101,"width":1816,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5860627947f341eab19b85b24f5f8558","type":"text","conversion_output":true,"text":"items on the UDI and these symptoms must be at least moderately bothersome. Only \\(40 \\%\\) of women in the","text_display":" items on the UDI and these symptoms must be at least moderately bothersome. Only \\(40 \\%\\) of women in the","confidence":1,"confidence_rate":1},{"cnt":[[146,2148],[1886,2148],[1886,2194],[146,2194]],"region":{"top_left_x":146,"top_left_y":2148,"width":1741,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99df05e298734bb8a4b9256cb9bd246d","type":"text","conversion_output":true,"text":"OPTIMAL trial reported mixed UI. In addition, all women in OPTIMAL had at least stage 2 symptomatic","text_display":" OPTIMAL trial reported mixed UI. In addition, all women in OPTIMAL had at least stage 2 symptomatic","confidence":1,"confidence_rate":1},{"cnt":[[146,2191],[1953,2191],[1953,2237],[146,2237]],"region":{"top_left_x":146,"top_left_y":2191,"width":1807,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b327c7a6d3804711b2639a30aa594e51","type":"text","conversion_output":true,"text":"pelvic organ prolapse and all underwent apical prolapse suspension procedures as part of the intervention.","text_display":" pelvic organ prolapse and all underwent apical prolapse suspension procedures as part of the intervention.","confidence":1,"confidence_rate":1},{"cnt":[[146,2234],[1835,2234],[1835,2279],[146,2279]],"region":{"top_left_x":146,"top_left_y":2234,"width":1689,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9632e1e881a646aea676b485b4029629","type":"text","conversion_output":true,"text":"Existing data support that urgency and urge incontinence symptoms may be associated with severe","text_display":" Existing data support that urgency and urge incontinence symptoms may be associated with severe","confidence":1,"confidence_rate":1},{"cnt":[[146,2277],[1871,2277],[1871,2325],[146,2325]],"region":{"top_left_x":146,"top_left_y":2277,"width":1726,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c352c528a63b40a18b75edd1d4fb9b1a","type":"text","conversion_output":true,"text":"prolapse and surgical correction of prolapse may improve OAB symptoms. \\({ }^{111}\\) In addition, there is solid","text_display":" prolapse and surgical correction of prolapse may improve OAB symptoms. \\({ }^{111}\\) In addition, there is solid","confidence":0.98046875,"confidence_rate":0.9998314286939466},{"cnt":[[146,2322],[1940,2322],[1940,2368],[146,2368]],"region":{"top_left_x":146,"top_left_y":2322,"width":1795,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db5bcd84e6684a87b2193aa8e6fb6c41","type":"text","conversion_output":true,"text":"evidence supporting that MUS is an effective treatment for SUI and therefore it is plausible that BPTx may","text_display":" evidence supporting that MUS is an effective treatment for SUI and therefore it is plausible that BPTx may","confidence":1,"confidence_rate":1},{"cnt":[[146,2368],[1931,2368],[1931,2413],[146,2413]],"region":{"top_left_x":146,"top_left_y":2367,"width":1786,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44c41347e6594a079fd42895b60cf73a","type":"text","conversion_output":true,"text":"not provide any additional effect in the OPTIMAL study population. However, there is minimal high-quality","text_display":" not provide any additional effect in the OPTIMAL study population. However, there is minimal high-quality","confidence":1,"confidence_rate":1},{"cnt":[[146,2411],[1936,2411],[1936,2456],[146,2456]],"region":{"top_left_x":146,"top_left_y":2410,"width":1790,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c566b656dbf42ab9f1414d82eb98363","type":"text","conversion_output":true,"text":"data regarding outcomes in MUI and there is evidence supporting that MUI is a risk factor for MUS failure.","text_display":" data regarding outcomes in MUI and there is evidence supporting that MUI is a risk factor for MUS failure.","confidence":1,"confidence_rate":1},{"cnt":[[146,2454],[1871,2454],[1871,2499],[146,2499]],"region":{"top_left_x":146,"top_left_y":2453,"width":1726,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6d050d5560a42b381546c8ab9206089","type":"text","conversion_output":true,"text":"Finally, the BPTx component in OPTIMAL was developed as a prophylactic intervention, whereas the","text_display":" Finally, the BPTx component in OPTIMAL was developed as a prophylactic intervention, whereas the","confidence":1,"confidence_rate":1},{"cnt":[[146,2496],[1886,2496],[1886,2546],[146,2546]],"region":{"top_left_x":146,"top_left_y":2496,"width":1741,"height":50},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42c09224a4b8464daea02a0c335b690f","type":"text","conversion_output":true,"text":"combined effect of MUS and BPTx is designed as a treatment intervention in ESTEEM. For all of these","text_display":" combined effect of MUS and BPTx is designed as a treatment intervention in ESTEEM. For all of these","confidence":1,"confidence_rate":1},{"cnt":[[1036,2548],[1089,2548],[1089,2593],[1036,2593]],"region":{"top_left_x":1035,"top_left_y":2548,"width":55,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3081d14b36ec4ca4bfa5d406f33c75c5","type":"page_info","conversion_output":false,"text":"35","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef97e1f19f904bf49077209bb743e2c5","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-36","page":36,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0da781e85a2c482d99992264e864f6fd","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a083682d30314122a72bcd22fc8c17a0","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d003d0349064277b1e381a7e606c5db","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,256],[146,256]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2a0d46f990240cd83b96613b34ecd2d","type":"section_header","conversion_output":false,"children_ids":["e25daac619ad4a0cae588e9945a63728"],"text":"","text_display":""},{"cnt":[[150,217],[354,217],[354,251],[150,251]],"region":{"top_left_x":150,"top_left_y":216,"width":205,"height":36},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e25daac619ad4a0cae588e9945a63728","type":"text","conversion_output":true,"parent_id":"b2a0d46f990240cd83b96613b34ecd2d","text":"Confidential","text_display":"\n\n\\section*{Confidential}","confidence":1,"confidence_rate":1},{"cnt":[[146,262],[1888,262],[1888,303],[146,303]],"region":{"top_left_x":146,"top_left_y":262,"width":1743,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df20c31e28aa43e2a306b37af2fb9300","type":"text","conversion_output":true,"text":"reasons, we believe that the early findings from OPTIMAL do not directly address the aims proposed in","text_display":"\nreasons, we believe that the early findings from OPTIMAL do not directly address the aims proposed in","confidence":1,"confidence_rate":1},{"cnt":[[148,305],[1046,305],[1046,346],[148,346]],"region":{"top_left_x":148,"top_left_y":305,"width":899,"height":41},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6276265e1c4042a39d4e6d56032e1cc3","type":"text","conversion_output":true,"text":"ESTEEM and are not applicable to a MUI population.","text_display":" ESTEEM and are not applicable to a MUI population.","confidence":1,"confidence_rate":1},{"cnt":[[271,348],[1923,348],[1923,393],[271,393]],"region":{"top_left_x":270,"top_left_y":348,"width":1653,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43d01b30fbd446dc9d2d6d2ae3c7dc19","type":"text","conversion_output":true,"text":"The intervention in ESTEEM has been designed to focus on SUI and UUI symptoms and includes","text_display":"\n\nThe intervention in ESTEEM has been designed to focus on SUI and UUI symptoms and includes","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1959,391],[1959,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1814,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b99320f574544999f787392c8269721","type":"text","conversion_output":true,"text":"only components that address these 2 symptom constellations. Differences between the ATLAS, OPTIMAL","text_display":" only components that address these 2 symptom constellations. Differences between the ATLAS, OPTIMAL","confidence":1,"confidence_rate":1},{"cnt":[[146,438],[1068,438],[1068,479],[146,479]],"region":{"top_left_x":146,"top_left_y":438,"width":922,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"174427e4260440959d264321af185e19","type":"text","conversion_output":true,"text":"and ESTEEM interventions are presented in Table 10.","text_display":" and ESTEEM interventions are presented in Table 10.","confidence":0.99951171875,"confidence_rate":0.9999911200303706},{"cnt":[[146,567],[1940,567],[1940,610],[146,610]],"region":{"top_left_x":146,"top_left_y":567,"width":1795,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0f87dac8a66412e9b907186bc78da98","type":"figure_label","conversion_output":false,"text":"Table 10. ATLAS and OPTIMAL behavioral therapy interventions and control compared to ESTEEM","text_display":"","confidence":0.9326171875,"confidence_rate":0.9992735924501479},{"cnt":[[127,606],[2030,606],[2030,2546],[127,2546]],"region":{"top_left_x":126,"top_left_y":605,"width":1905,"height":1941},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dc0a63132e54009aece2aaa7b4e467c","type":"table","conversion_output":true,"children_ids":["aab686f31dce4bbca1610ec81df57edb","eda5587b2bf1410ead8f40c8ad74e8a4","aab3fea9128244d38d605bb09d8d7167","59096cdbff214a1a8ed913e504246ef0","ba811ab43d1b4b809afd9680d0b11cfe","3d41663ca9004baa9860b854b31ef09f","5c749889e199458b98b0e226a5d21452","53b522cdf2324cbeac66e39e912d202c","1dbd5a86dd6f4b75a3da6a12da3c9c63","7838bca60294433da67fa40025502a25","217c217c63e54c56be5a29bd6668a7de","09c2e42de09d4df59c5d1b7019e51cd2","d76003741f9245d6bc16f6299cf963a7","af638859e3494232920e2683f082424f","336d43673fd442c0a03d81c5bbb3fdb1","d411f34edae3489a821c1fd027c065d2","80532eee00404618bf8194b795464188","343d1a34c56d455090722c8dd0479190","4e48ea427428495d92898844c8814dad","c9e47f64658d4475b56065120125360f","51a391f730794ae99306253972adc87f","cd6074add5fb4e6fbf6d24d8741fa937","9ed2a11502da45da8ac22f413cbfc671","3b4715c5a4774bc289d8776989f19c12","7156a1f5f0464f488e7d1307bb485572","2f366fa0963c4ceb9d5c6f2e4cf6f391","0d510e2f9bb54a63a55567f4c3999692","55bf7d45960b476283ab7d7b77a061a2","575f6147fa7f4fb0b428f900f660ead5","ebbd6f44cfb84c64a50278cbd72cbdf3","49b5c65a28674527894192b96d029aea","f70a2265e75149a7966792006f491ca1","73baf08007fd4f17a6af8fa31bd77e0e","758a55e0de3e47569c55f91f235d0197","a26ebe07a16c409b93761fa71590498f","51f6485430914fc0bd03d0ffd487afbe","f825d9a71351405aad528c59d3e952eb","6352e493a35b45cc879b94600bcfa295","6081fafde240435c918e581a4ef2e01e","863d2c4a80764412bec6bf3f12f4f1bd","61d65ebb9944412eafd2ebcdde72f742","1d47ea072db544efbaf1683eb5c29be6","eef76ace23824a6da9dc483c117bd6eb","283d906a7b0348ecbe3060b21ab9b03b","b322ef2d5ccc4842ae4e3c2b352bcdbc","300f1365b8ac48d79f2caf980a3d8cbb","f2f602976a5b4d878c56e469f1253433","1e40b7e3f4aa4fe08a1804ed741be161","4befeb95ee394d98b7a7d8962b2793ef","4b3a1ef5b5574a149253b1c9408efe7f","df5f58716de346c19b50d45f71f55274","bf31b3c377aa493c9ac08be518d79f57","f95436f6b0a54ec5a0e94c12bd784844","9e09e4b51d4c4f5788d73b2aacb978d8","62f726ac8a2b41a09a2841bb9f2755d4","ae7724f7dafa4e14831b7c07f9762355","ec370aeec3e7487793aaef3af30053fb","d6d4a85c3a1a467dafa6b8a9c5b9da30","ee4718a41cb746efaa6b5091664352e8","16f1a2cad6344b40b7db396d7063299d","85e764c442e44678857b80854fd4d27c","2954d433e35c4b0594227f750b73c06b","04d742117a3445c48fbb2ef67ffd5afc","a3d7b89aea054790aa9726c719f32118","88dc1acae97340fca097aca69f9f1fcc","ed7cccfdfa1143a18c8f07c6be0d54b5","b9fbb2ea0a9c4126b0809807bda9a692","5455734924ec44bfbd5bb678258ba63b","58250dce8a934f95aae063f349befc22","d5e2546d792f48679a8607097429a300","462676006cac4a2e82d925149846e911","127666e683654cdc8b345ec9410f0c60","ddb213d8d13142ae8aed0db27e0ed4de","960eea950d4c48a6a1ab11a44e2ac22b","85cc941a13cd4cf2af3e480b3f97e9cf","7664641c5e61426b8d8964f7d29845da","96511c0bed3f4024a6da26f1b5489678","84779a040cad4e578f569bf60c07a45a","d17d2602f53d4061986044cd39bd311e","96ae1e2c22c94291a560662b00530bb1","59db090799c543a28b678dcdab1ed880","6d09162f92114a0a97ffa6f221daf22b","4f53056d9fb945f7b0c56ac29ea9c690","7931b6102c7b4ac58804d41f528bcdbf","2f56f749c54d410d9505ae9f944f7f7e","7f8bea8952ea44baa5e51a331ef05ad9","d41d5202328f4e3faa7b2d0f5bd898d4","4ddaebf009d54ec48588b1ef534c71d1","1d2e62ea6ebb49fd9de1ff0ab6090af0","5459d62e29cc422dab27278cf2730f98","c0b729730675405eb3f59d0cfedf2f0f","d837a2d62a3c48baad30c18951d00e42","48a3581d0dd0436c98ed748a96e1eebf","58a9944ead3648ea94616c2ee65ce717","26c60c78bbc2445da18a01e54f437fc5","417a264d41ca413bbd00a7d4d4d2105a","9f92682d2bff486f986814a872774d39","0d8b771809944e838132cd81a4c7c5b2","fa03fb3c68d44a2aba57dcb52ca0a696","4d8892dba94f41649b90b8d1f634d3c8","bd5a5f6cceec4983ab25111b5010cae5","98854ee13880407e87311d28eb639ffc","3d09b2b35e854516b682793950646de3","62fc2c52a5b1402681be9454771ee305","696ccf30847b4118825a5ffcb3e6a7e1","356b4664adf04da18d9c1a18b1cc693f","78c0ed4e07b845d4b25734ae26e21b8c","cbc21fe8f5924e90ba34737660a3f50f","5a0eaaf428ea43ec9364762cd8273867","a180b98167164e75af67f0b9d356ee0b"],"selected_labels":["b0f87dac8a66412e9b907186bc78da98"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline Study & ATLAS & OPTIMAL & ESTEEM \\\\\n\\hline Study design & Pessary vs BPTx vs both & Periop BPTx vs control + vaginal suspension & Combined periop BPTx+MUS vs control \\\\\n\\hline Study population & -SUI or SUI predominant desiring non-surgical treatment & \\begin{tabular}{l}\n-Stage 2-4 prolapse with presence of SUI -All women underwent vaginal vault suspension \\\\\n-SUI defined as affirmative response to SUI item on UDI and objective confirmation\n\\end{tabular} & \\begin{tabular}{l}\n-No significant prolapse \\\\\n-No vaginal vault repair allowed \\\\\n-Bothersome mixed UI desiring midurethral sling (defined as at least moderate bother for both SUI and UUI items on UDI and confirmation on bladder diary)\n\\end{tabular} \\\\\n\\hline Primary outcome definition & PGI-I and PFDI \\(\\leq\\) somewhat bother for SUI items & \\begin{tabular}{l}\nUDI (urinary outcome) \\\\\n-Urinary outcome powered to detect 11 point diff in UDI\n\\end{tabular} & \\begin{tabular}{l}\nUDI(total)-long form \\\\\n-Powered to detect 35 point diff in UDI(total), 15 point in UDI(irrit), and 8 points UDI(stress) scales.\n\\end{tabular} \\\\\n\\hline Primary outcome time point & 3 months & \\begin{tabular}{l}\n-Urinary-short term 6 months for urinary sxs \\\\\n-Prolapse-long term 2 years\n\\end{tabular} & 12 months \\\\\n\\hline \\# visits & 4 & 5 & 6 \\\\\n\\hline Duration of active treatment & 6 weeks & 2 weeks preop to 3 months postop & 2 weeks preop to 6 months postop \\\\\n\\hline Interval between visits & Q2-3 weeks & \\begin{tabular}{l}\nPostop: (Q2-4 wks) \\\\\n2, 4, 8 wks \\\\\n3 months\n\\end{tabular} & \\begin{tabular}{l}\nPostop: \\\\\n2, 4, 6, 8 weeks \\\\\n6 months\n\\end{tabular} \\\\\n\\hline \\multicolumn{4}{|l|}{Intervention components} \\\\\n\\hline 1. Bladder diary review & Yes & No & Yes \\\\\n\\hline 2. PFMT, technique eval & Yes & Yes & Yes \\\\\n\\hline 3. Standardized protocol for & No & No & Yes \\\\\n\\hline PFMT exercise progression & No & No & Yes \\\\\n\\hline \"special circumstances\" & & & \\\\\n\\hline 3. SUI strategies & Yes & Yes & Yes \\\\\n\\hline 4. UUI strategies & Yes & Yes & Yes \\\\\n\\hline 5. Dysfx void strategies & No & Yes & Yes \\\\\n\\hline 6. Colorectal Sx strategies & No & Yes & No \\\\\n\\hline 7. Verbal/written home & Yes & Yes & Yes \\\\\n\\hline PFME Px & & & \\\\\n\\hline & Yes & Yes & Yes \\\\\n\\hline & No & Yes & No \\\\\n\\hline 9. Addressing other PFD Sx & & & \\\\\n\\hline 10. Other written educational materials & SUI, UUI, PFME, Diary & SUI, UUI, PFME, Postop instructions, lifting, healthy bladder, healthy bowel & SUI, UUI, PFME, Diary \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 10. ATLAS and OPTIMAL behavioral therapy interventions and control compared to ESTEEM}\n\\begin{tabular}{|l|l|l|l|}\n\\hline Study & ATLAS & OPTIMAL & ESTEEM \\\\\n\\hline Study design & Pessary vs BPTx vs both & Periop BPTx vs control + vaginal suspension & Combined periop BPTx+MUS vs control \\\\\n\\hline Study population & -SUI or SUI predominant desiring non-surgical treatment & \\begin{tabular}{l}\n-Stage 2-4 prolapse with presence of SUI -All women underwent vaginal vault suspension \\\\\n-SUI defined as affirmative response to SUI item on UDI and objective confirmation\n\\end{tabular} & \\begin{tabular}{l}\n-No significant prolapse \\\\\n-No vaginal vault repair allowed \\\\\n-Bothersome mixed UI desiring midurethral sling (defined as at least moderate bother for both SUI and UUI items on UDI and confirmation on bladder diary)\n\\end{tabular} \\\\\n\\hline Primary outcome definition & PGI-I and PFDI \\(\\leq\\) somewhat bother for SUI items & \\begin{tabular}{l}\nUDI (urinary outcome) \\\\\n-Urinary outcome powered to detect 11 point diff in UDI\n\\end{tabular} & \\begin{tabular}{l}\nUDI(total)-long form \\\\\n-Powered to detect 35 point diff in UDI(total), 15 point in UDI(irrit), and 8 points UDI(stress) scales.\n\\end{tabular} \\\\\n\\hline Primary outcome time point & 3 months & \\begin{tabular}{l}\n-Urinary-short term 6 months for urinary sxs \\\\\n-Prolapse-long term 2 years\n\\end{tabular} & 12 months \\\\\n\\hline \\# visits & 4 & 5 & 6 \\\\\n\\hline Duration of active treatment & 6 weeks & 2 weeks preop to 3 months postop & 2 weeks preop to 6 months postop \\\\\n\\hline Interval between visits & Q2-3 weeks & \\begin{tabular}{l}\nPostop: (Q2-4 wks) \\\\\n2, 4, 8 wks \\\\\n3 months\n\\end{tabular} & \\begin{tabular}{l}\nPostop: \\\\\n2, 4, 6, 8 weeks \\\\\n6 months\n\\end{tabular} \\\\\n\\hline \\multicolumn{4}{|l|}{Intervention components} \\\\\n\\hline 1. Bladder diary review & Yes & No & Yes \\\\\n\\hline 2. PFMT, technique eval & Yes & Yes & Yes \\\\\n\\hline 3. Standardized protocol for & No & No & Yes \\\\\n\\hline PFMT exercise progression & No & No & Yes \\\\\n\\hline \"special circumstances\" & & & \\\\\n\\hline 3. SUI strategies & Yes & Yes & Yes \\\\\n\\hline 4. UUI strategies & Yes & Yes & Yes \\\\\n\\hline 5. Dysfx void strategies & No & Yes & Yes \\\\\n\\hline 6. Colorectal Sx strategies & No & Yes & No \\\\\n\\hline 7. Verbal/written home & Yes & Yes & Yes \\\\\n\\hline PFME Px & & & \\\\\n\\hline & Yes & Yes & Yes \\\\\n\\hline & No & Yes & No \\\\\n\\hline 9. Addressing other PFD Sx & & & \\\\\n\\hline 10. Other written educational materials & SUI, UUI, PFME, Diary & SUI, UUI, PFME, Postop instructions, lifting, healthy bladder, healthy bowel & SUI, UUI, PFME, Diary 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Standardized urodynamic evaluation (UDE) will be performed preoperatively - There continues to be","text_display":"\ne. Standardized urodynamic evaluation (UDE) will be performed preoperatively - There continues to be","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[146,1886],[1841,1886],[1841,1931],[146,1931]],"region":{"top_left_x":146,"top_left_y":1886,"width":1696,"height":46},"line":73,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d84ed3980b7e49cfb4cddcaa068cf6b8","type":"text","conversion_output":true,"text":"controversy regarding the usefulness of UDE for preoperative evaluation of SUI. However, it is often","text_display":" controversy regarding the usefulness of UDE for preoperative evaluation of SUI. 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Patient-reported outcomes and questionnaires - includes UDI, IIQ, EQ5D, Adaptation questionnaire, PGI","confidence":1,"confidence_rate":1},{"cnt":[[146,2329],[746,2329],[746,2374],[146,2374]],"region":{"top_left_x":146,"top_left_y":2328,"width":600,"height":47},"line":83,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9103529e0fd4bee9de610301af22808","type":"text","conversion_output":true,"text":"I, PGI-S, OAB-q, OAB-sat-q, PISQ,","text_display":"I, PGI-S, OAB-q, OAB-sat-q, PISQ,","confidence":0.9458270072937012,"confidence_rate":0.9985354000431256},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":84,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c1d4a8225854e6082e648e4d586b756","type":"page_info","conversion_output":false,"text":"37","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a10042cb4f04b7693a9be246e0d741c","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-38","page":38,"lines":[{"cnt":[[146,125],[410,125],[410,165],[146,165]],"region":{"top_left_x":146,"top_left_y":124,"width":265,"height":42},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14ab1ac01c2c46148c2e7e168719276d","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,125],[1910,125],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":124,"width":140,"height":42},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"352a7418be744b6caacdd2c059a02dcc","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999593007867263},{"cnt":[[146,168],[312,168],[312,213],[146,213]],"region":{"top_left_x":146,"top_left_y":167,"width":166,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dacacae35b204181915a18f202676b86","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,256],[146,256]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29bd7439760a4e1f94f868bfd0a6ddc6","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[142,254],[870,254],[870,307],[142,307]],"region":{"top_left_x":141,"top_left_y":253,"width":730,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0aa1cd2e3d44d3abb7e468b0b9a0943","type":"section_header","conversion_output":false,"children_ids":["25423a3db839479e882a7e5eb46e65a1"],"text":"","text_display":""},{"cnt":[[146,258],[866,258],[866,303],[146,303]],"region":{"top_left_x":146,"top_left_y":257,"width":720,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25423a3db839479e882a7e5eb46e65a1","type":"text","conversion_output":true,"parent_id":"d0aa1cd2e3d44d3abb7e468b0b9a0943","text":"5.5.2. Postoperative visits and procedures","text_display":"\n\n\\subsection*{5.5.2. Postoperative visits and procedures}","confidence":1,"confidence_rate":1},{"cnt":[[271,314],[1824,314],[1824,359],[271,359]],"region":{"top_left_x":270,"top_left_y":313,"width":1555,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6289b486402a4b4bbab45f3627d8f434","type":"text","conversion_output":true,"text":"Patients will undergo clinical and PRO assessments at 3 months, 6 months, and 12 months","text_display":"\n\nPatients will undergo clinical and PRO assessments at 3 months, 6 months, and 12 months","confidence":1,"confidence_rate":1},{"cnt":[[146,357],[1949,357],[1949,402],[146,402]],"region":{"top_left_x":146,"top_left_y":356,"width":1803,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65e3371242e04d8294f0de862d1b6b48","type":"text","conversion_output":true,"text":"postoperatively. (See Table 11 above). The primary outcome will be at 12 months. Additional treatment for","text_display":" postoperatively. (See Table 11 above). The primary outcome will be at 12 months. Additional treatment for","confidence":0.998046875,"confidence_rate":0.9999831463934391},{"cnt":[[146,400],[1914,400],[1914,449],[146,449]],"region":{"top_left_x":146,"top_left_y":399,"width":1769,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57d079513d2f4d2d8e80ee593928b17d","type":"text","conversion_output":true,"text":"patients with persistent OAB symptoms should not be offered in the first 3 months, given this time period","text_display":" patients with persistent OAB symptoms should not be offered in the first 3 months, given this time period","confidence":0.6095654964447021,"confidence_rate":0.9956289713479527},{"cnt":[[146,447],[1979,447],[1979,492],[146,492]],"region":{"top_left_x":146,"top_left_y":446,"width":1833,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e875325270e34654b8b815ed39d5f3f9","type":"text","conversion_output":true,"text":"may still represent recovery from acute events related to surgery. Patients requesting additional treatment in","text_display":" may still represent recovery from acute events related to surgery. Patients requesting additional treatment in","confidence":1,"confidence_rate":1},{"cnt":[[146,488],[1966,488],[1966,535],[146,535]],"region":{"top_left_x":146,"top_left_y":487,"width":1820,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65e7c17aadf947c482ab4a8920a1cdd4","type":"text","conversion_output":true,"text":"the first 12 months will be considered treatment failures, and will complete PRO assessments at the time of","text_display":" the first 12 months will be considered treatment failures, and will complete PRO assessments at the time of","confidence":1,"confidence_rate":1},{"cnt":[[146,533],[1962,533],[1962,578],[146,578]],"region":{"top_left_x":146,"top_left_y":532,"width":1816,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c5a0edc93b446b98b3eaf0e9ad1f15f","type":"text","conversion_output":true,"text":"initiation of additional treatment. Any additional long term follow up beyond 12 months, consideration would","text_display":" initiation of additional treatment. Any additional long term follow up beyond 12 months, consideration would","confidence":1,"confidence_rate":1},{"cnt":[[146,574],[1536,574],[1536,623],[146,623]],"region":{"top_left_x":146,"top_left_y":573,"width":1391,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee4e877502c34dcc8c0fef2f10f68a95","type":"text","conversion_output":true,"text":"need to be given to the natural history of progression and remission of OAB. \\({ }^{112,113}\\)","text_display":" need to be given to the natural history of progression and remission of OAB. \\({ }^{112,113}\\)","confidence":0.8014531745070599,"confidence_rate":0.9976729357065806},{"cnt":[[1036,2548],[1089,2548],[1089,2593],[1036,2593]],"region":{"top_left_x":1035,"top_left_y":2548,"width":55,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffefd653dc2449e3a7a8cab68444853c","type":"page_info","conversion_output":false,"text":"38","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e742db0f30564a1692f194c8ee70d404","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-39","page":39,"lines":[{"cnt":[[120,129],[385,129],[385,165],[120,165]],"region":{"top_left_x":120,"top_left_y":128,"width":265,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aade9d408dde4da984954e9b62aa0dbb","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1745,125],[1884,125],[1884,165],[1745,165]],"region":{"top_left_x":1744,"top_left_y":124,"width":141,"height":42},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da4c058b403540adb15e8182b5c6077f","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999593007867263},{"cnt":[[120,172],[286,172],[286,211],[120,211]],"region":{"top_left_x":120,"top_left_y":171,"width":166,"height":40},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a573fce91f7a48008310ba75460d8184","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,215],[329,215],[329,256],[120,256]],"region":{"top_left_x":120,"top_left_y":214,"width":209,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd8772bae3fc438eb7fd56ab774ae96c","type":"text","conversion_output":true,"text":"Confidential","text_display":"\n\nConfidential","confidence":1,"confidence_rate":1},{"cnt":[[120,301],[1121,301],[1121,346],[120,346]],"region":{"top_left_x":120,"top_left_y":300,"width":1002,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99e4d897cd7540f9a25cf720e8518a0e","type":"figure_label","conversion_output":false,"text":"Table 11. Timeline of visits, events, and data collection","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[88,339],[2443,339],[2443,1626],[88,1626]],"region":{"top_left_x":88,"top_left_y":339,"width":2355,"height":1288},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aaf7a9790fec47a6b57199f88e8bf13d","type":"table","conversion_output":true,"children_ids":["e7230cfdcae64d4681a286b912f752bf","3a99d2418f484bc3b4ff522b8576d3fc","4856a5faedce4354ade27a41f6bc8098","45c419e2b6d6401c95e8f90de407081f","a54c3b61a60d40d5abf7531c28284751","2d562866417848ef92b6fa85ce92fceb","099b749b7bc44a519d51e8f5908e2d7f","77c2ebc994324e51826ce06e4bec0031","b9e3f4fcf93c47d69ce7c05277eaea96","03c8f4110c314797b2c502677fa024ed","d63d4ecdf5704bf6ab7b7794ddd69596","c5c3794cda66425a9cd73559337ac00d","462ff87325c148468d2ea306a17408fb","ada57660a29548fbbddc7bc95037602a","9456db61ada844f283c34c1f692b61d5","a0aec1fbc35a4d2baf75951de71e23d7","405b3b7b98a84426956d942a02d9b6f2","f6e5750c31de409a967504a65fd87d0a","0d7567b15e864e2fbf91767dc105773c","c8b730a2158942fcbca3384105f16922","56823534b9804a96ab7dfd34a0f49def","0d57d8424b7946eb88a6edbc18826948","c146033d471e48b9b26c8aab7f00dc0c","d11b8ba4f15c4475a25a23b67c477b8d","b83f01e5e5794f60a16ad30b159df92c","88edbe93f7b14d9bab29b5f02ebd1330","b74bdc5c70e74d32ba51715edd9d1b8f","36605c74c20347888201d49f9512d732","bb37186fc6c64f2f9c5817bd3f859205","9a25237822dc49988effa85a3311fdfa","9e42d84a646c46c6930bdbe105265d57","7b98549d1f6e400fbc41ef479e033032","024788b9c03b4fbc967fa63ae5c86f6a","3f1445138b524859be93b960def2ee0a","4b9cff60109e410fb2306b99cbddf7de","83615d6c035a4d9d909a49c6764ce489","5c68aebcf5e04468bfbc113e4aaaaefe","08d41816e1e6440390e7482362381362","c1398ea2dd9747eeb982f286f0e142a6","0f64c5a7feab4e97953a6d962ae8a090","619e861e4e6447d8ba70c81bb4d6b0d6","379f357deb5a45c5b71e65fdacc896b5","c4a3967eebdc45e5a7cbf39f5be278c5","00130c07cdaf4bcbba7bffa17d33fad5","a08130cd53ff4985b5ef6b461e8bd64a","78beb0d9c2f14a1aa3891b5859bc671d","7d4e8f6396b0449bb7b182f45ed5351f","68d1a579aa13450f8fc50d4ba387a540","af44620619a844cc9c663b4bb458ec32","45267d2c3c364f44b9dd5c979c3bb69b","20ec4d13453b4ac6a3c695be6d8934e9","df12a2b7ad5a4ee7a1bd1f6b6650d718","fdeab4e1a78e47799e5b9d6f9abec4ed","9d860e49a42d4fcc87a59f533ca0997e","40cf0e308bd5472b9d2253e1b71abebf","af13b5fbcb3b4e8e91f9583407853a9c","65fd5ea5b6d84942b6fb115e16d487f4","17c927d46cd74f32bf5856ede747d9f2","d86307d1672d43e1a811373618f3263c","1788f6fdae1c4d32a168bc03b1367e69","83ee295bdd694420860b91c238da8b04","8f6da280cd1547d38d2dd0c54983aec9","f1a655ff35aa4de1bd955d44b1b9eace","1a978eb67d57424a9280b1c2e787a144","c67d7c3868cb4b058f12232137b4b64f","c9e51738da6544c2a1f4dac53392d653","406b2a2607fb454d841bf9068d5d657c","d282af24813b4ef1bd1c53d5787005a3","a48cedbc9ce04b59a208cf33be93b16d","d6c82631c1914e2e947e740404b89e89","5adaba36c88c442aa128a1bd4c9f0ea4","72dff764e1b549d4857d7a8c0bb4b78f","b4de379e56414d27966cce546a6a2d73","4a9311a3fc814cbfa1a96197dd7be0e9","1fd739aae28a4cb4af4d26919c069ee1","4dbea1ff784140349ca41ee4b74e410f","ce34e5c68a574b588c949bde93345571","af43a753539f428eb0932ce7c1ef632b","dca8059a72a04b75b0a3118e3129f016","67da36eda9ab47e1946e22d09826544e","9d584a42df7b40098224e21e20e61fa8","d1717b833b7d4a3b89b4db91543e2979","42244e1be4db42869c3db61692b96b5d","259f7399a3534c9ebced0d7af18df91d","114345edcd434efbb3c105718a0c834b","655dc8e1347f4976b5d76b67d285e5f0","d25836eb75d34c3aa205f75e32041c15","1fd863d505ec41f39aa59c7062bd7a2e","281aad5afb744a22bc1876c63c563299","8ae0bce3456d4e179e06a2da267b8cdb","afd906e2aab14a4fb921c6d1644b9094","5bc8ecc0339448e386761e198b47ad68","7cd360e7d6fb4271bd16775702461c5f","5eb7b221220a4cb39c847e1a7ef55420","f68c8d83041e4389817f41859f60e933","72401e93a56942d1acefdd69da6c8a35","d91db33c117a4d11b84edd7a602af9ba","99ac4b37903a491796349928ef01df1e","6349dc9014514d9a9aadec3cd3221eb8","f34a35e41d654cf78a6016284f00242e","07f6fbef64ac477a9c7f9dc0a4b26b35","6ca9f50f43484b90961b37ec6c77ae30","70b57e8488e949598cde93c237ba7eaa","05a00b04a848444d9f5cb621eb37b647","3c4b8a800fad440cb5e856cb1afffa8b","bd510943e84e408086b456afada707ce","f59a239a99424a6cbf6128348230e098","8d2fe5a4dbb6481493120e587bc4f193","4f9a96f4a84948159444e4def3579bbc","c72712edae884890a806a4db03344269","4129c4926ffd40deb4a65bdeedd5fa96","9cb2492b553d47f58da7c60fd6701bf0","3ccde826181d4f6ba013dd9d1f2caeaa","96a9e7bca04547f491966b367c18abac","21fb4b5a76fd43c4b6fe211c3f935d87","80ffe85152414d5493b9d86c5b72d180","f5490682fb1d4ea197cbcee22d236cfd","a671c46bf89b452a9f15611aea858e1d","27f09b250d574e9fa6e6d195958c635c","62ec1088a0284955a3b0d59bdc5da6da","806ac4d95b7d451681bd1e26f1886816","927996bc325b4ad58972e6925e9498da","4d57b4886cf4466d8d1dc17d2491d909","cf1d78f6d3244b1087278bc96f67022b","1a8deba7547345ce95e52370c6852ac4","abab787214df49929a5a5ed97f780ce1","30ea8a5ca53145ff863a7d2e75e5386f","875fbac4ff5b406e9a96ac04f29006c8","63bf84c4958f4df2b24893a012e12138","1443ad5b58d2433f8f757ba811c22c3f","8b104e94f1f74fe8940d7cffee0e64cd","371839f31d2d4a99bec450f071141a3b","a664461e194240289ed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& Baseline & Randomization visit (T1-5 wks preop) & Preop BTPx visit (range 1-5 wks preop) & Surg MUS (T0) & Call (2-4d postop) & 2 wk postClinic & 4 \\& 6 wks post & \\(8 ~ w k\\) post- & 3 mo postClinic and QoL & 6 mo postClinic and QoL & 12 mo postClinic and QoL \\\\\n\\hline \\multirow[t]{2}{*}{Estimated duration of clinic and/or BPTx visit for each group} & \\multirow{2}{*}{} & Both: 1.52 hr & Control: N/A & \\multirow{2}{*}{} & Contr: N/A & Control: 1.5 hr & Control: N/A & Control: 1 hr & \\multirow[t]{2}{*}{Both: 1.5 hr} & Control: 1.5 hr & \\multirow[t]{2}{*}{Both: 1.52 hr} \\\\\n\\hline & & & Interv: 1.5hr & & Interv: 15 min & Interv: 2.5 hr & Interv: 1 hr & Interv: 2 hr & & Interv: 2.5 hr & \\\\\n\\hline \\multicolumn{12}{|l|}{All subjects} \\\\\n\\hline Consent & X & & & & & & & & & & \\\\\n\\hline Coordinator visit & X & X & & & & X & & X & X & X & X \\\\\n\\hline Masked clinical staff visit (for PFM measures) & & X & & & & X & & X & & & X \\\\\n\\hline Hx/PE (update) & & & 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We assumed that \\(30 \\%\\) of women in","text_display":" month follow up period (refer to the statistical analysis plan for details). We assumed that \\(30 \\%\\) of women in","confidence":1,"confidence_rate":1},{"cnt":[[146,1143],[1897,1143],[1897,1188],[146,1188]],"region":{"top_left_x":146,"top_left_y":1142,"width":1752,"height":47},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"366a6c7b2a444a77b7f18e5f62cc018d","type":"text","conversion_output":true,"text":"the MUS only group and \\(20 \\%\\) of women in the MUS+BPTx group would request additional treatment. In","text_display":" the MUS only group and \\(20 \\%\\) of women in the MUS+BPTx group would request additional treatment. In","confidence":0.96875,"confidence_rate":0.9996947706466276},{"cnt":[[146,1186],[1888,1186],[1888,1231],[146,1231]],"region":{"top_left_x":146,"top_left_y":1185,"width":1743,"height":47},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d86e6b2afea473e919377a81258a2d2","type":"text","conversion_output":true,"text":"TOMUS, \\(10-12 \\%\\) of women who had baseline MUI had persistent UUI postoperatively based on MESA","text_display":" TOMUS, \\(10-12 \\%\\) of women who had baseline MUI had persistent UUI postoperatively based on MESA","confidence":0.99853515625,"confidence_rate":0.9999853409306202},{"cnt":[[146,1229],[1901,1229],[1901,1274],[146,1274]],"region":{"top_left_x":146,"top_left_y":1228,"width":1756,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"550ad6e7bf38446dad2a30bc879fa26f","type":"text","conversion_output":true,"text":"responses and/or initiation of anticholinergic treatment. \\({ }^{24}\\) In Barber's TVT vs TOT equivalence trial, 70\\%","text_display":" responses and/or initiation of anticholinergic treatment. \\({ }^{24}\\) In Barber's TVT vs TOT equivalence trial, 70\\%","confidence":0.8837890625,"confidence_rate":0.9989795552074351},{"cnt":[[146,1276],[1846,1276],[1846,1319],[146,1319]],"region":{"top_left_x":146,"top_left_y":1276,"width":1700,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7ce5534010145e5a5a126ebb9d4d8b3","type":"text","conversion_output":true,"text":"reported baseline MUI and postoperatively, 30\\% of all women reported bothersome UUI with 16\\% of","text_display":" reported baseline MUI and postoperatively, 30\\% of all women reported bothersome UUI with 16\\% of","confidence":0.6513519287109375,"confidence_rate":0.9957221244316019},{"cnt":[[146,1319],[1888,1319],[1888,1364],[146,1364]],"region":{"top_left_x":146,"top_left_y":1319,"width":1743,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a21e5f9d79464f6a99985533abe03d96","type":"text","conversion_output":true,"text":"subjects on anticholinergic treatment postoperatively. \\({ }^{31}\\) In Abdel-Fattah's transobturator MUS trial, 25\\%","text_display":" subjects on anticholinergic treatment postoperatively. \\({ }^{31}\\) In Abdel-Fattah's transobturator MUS trial, 25\\%","confidence":0.9815141861326993,"confidence_rate":0.9998445219892322},{"cnt":[[146,1362],[1979,1362],[1979,1407],[146,1407]],"region":{"top_left_x":146,"top_left_y":1362,"width":1833,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8beb32e0c13d4d83aa84c6bc258ec1ac","type":"text","conversion_output":true,"text":"reported worsening OAB and almost all of these women were on anticholinergic treatment postoperatively. \\({ }^{34}\\)","text_display":" reported worsening OAB and almost all of these women were on anticholinergic treatment postoperatively. \\({ }^{34}\\)","confidence":0.76025390625,"confidence_rate":0.9977740030487667},{"cnt":[[146,1405],[1966,1405],[1966,1450],[146,1450]],"region":{"top_left_x":146,"top_left_y":1405,"width":1820,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23144bfd5a474660bb7906ee57f47421","type":"text","conversion_output":true,"text":"In Palva's TVT vs TVT-O trial, 174 women reported preoperative UUI and of these, 7 women ( \\(4 \\%\\) ) had tried","text_display":" In Palva's TVT vs TVT-O trial, 174 women reported preoperative UUI and of these, 7 women ( \\(4 \\%\\) ) had tried","confidence":0.87158203125,"confidence_rate":0.9988456643052814},{"cnt":[[146,1452],[1966,1452],[1966,1495],[146,1495]],"region":{"top_left_x":146,"top_left_y":1452,"width":1820,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b6b984765844713a09851f95de23dde","type":"text","conversion_output":true,"text":"anticholinergics postoperatively after 3 years. Therefore, based on existing MUS trials, the rate of additional","text_display":" anticholinergics postoperatively after 3 years. Therefore, based on existing MUS trials, the rate of additional","confidence":1,"confidence_rate":1},{"cnt":[[146,1495],[1893,1495],[1893,1540],[146,1540]],"region":{"top_left_x":146,"top_left_y":1495,"width":1747,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0ea355e4f764aa5a071d13a6a65c332","type":"text","conversion_output":true,"text":"treatment for OAB ranges from \\(4-25 \\%\\), supporting our conservative assumption that \\(30 \\%\\) of women will","text_display":" treatment for OAB ranges from \\(4-25 \\%\\), supporting our conservative assumption that \\(30 \\%\\) of women will","confidence":0.9844295748043805,"confidence_rate":0.9998573472901036},{"cnt":[[146,1538],[1025,1538],[1025,1583],[146,1583]],"region":{"top_left_x":146,"top_left_y":1538,"width":879,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cf0ea18da0141e0a6f815248b216d45","type":"text","conversion_output":true,"text":"request additional treatment in the MUS only group.","text_display":" request additional treatment in the MUS only group.","confidence":1,"confidence_rate":1},{"cnt":[[269,1624],[1171,1624],[1171,1674],[269,1674]],"region":{"top_left_x":268,"top_left_y":1624,"width":903,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddd34f99ec7b49cf98e2da4c941fe9af","type":"text","conversion_output":true,"text":"i. Primary outcome: MUI symptoms = UDI-total score","text_display":"\ni. Primary outcome: MUI symptoms = UDI-total score","confidence":0.9970703125,"confidence_rate":0.9999466561967442},{"cnt":[[281,1714],[1944,1714],[1944,1760],[281,1760]],"region":{"top_left_x":281,"top_left_y":1714,"width":1664,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6619a35cf5ad4c368edfe921067d8d45","type":"text","conversion_output":true,"text":"The MID for the UDI-total score published by Dyer et al is estimated to be 35 points. \\({ }^{50}\\) Assuming a","text_display":"\n\nThe MID for the UDI-total score published by Dyer et al is estimated to be 35 points. \\({ }^{50}\\) Assuming a","confidence":0.998046875,"confidence_rate":0.9999832904401549},{"cnt":[[146,1757],[1962,1757],[1962,1803],[146,1803]],"region":{"top_left_x":146,"top_left_y":1757,"width":1816,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"288145f5c5024b2694a08967eb32ab31","type":"text","conversion_output":true,"text":"two-sided alpha of .05, SD of 50.4, and true difference in mean change from baseline in UDI-total scores at","text_display":" two-sided alpha of .05, SD of 50.4, and true difference in mean change from baseline in UDI-total scores at","confidence":1,"confidence_rate":1},{"cnt":[[148,1800],[1818,1800],[1818,1846],[148,1846]],"region":{"top_left_x":148,"top_left_y":1800,"width":1670,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbe6cf1cf0e74c38b704cbcf9e54ef46","type":"text","conversion_output":true,"text":"1 year between treatment groups of 35,75 women per group would provide \\(90 \\%\\) power to detect a","text_display":" 1 year between treatment groups of 35,75 women per group would provide \\(90 \\%\\) power to detect a","confidence":0.9975595474243164,"confidence_rate":0.999976045038553},{"cnt":[[146,1848],[986,1848],[986,1893],[146,1893]],"region":{"top_left_x":146,"top_left_y":1847,"width":841,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0287645603d74b2cbd326e388d29f9db","type":"text","conversion_output":true,"text":"statistically significant difference between groups.","text_display":" statistically significant difference between groups.","confidence":1,"confidence_rate":1},{"cnt":[[271,1891],[1949,1891],[1949,1936],[271,1936]],"region":{"top_left_x":270,"top_left_y":1890,"width":1679,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"179406458a37482ab6a7cca98a110a6b","type":"text","conversion_output":true,"text":"ii. Secondary outcome: OAB symptoms= UDI-irritative subscale: For the UDI-irritative subscale, the","text_display":"\nii. Secondary outcome: OAB symptoms= UDI-irritative subscale: For the UDI-irritative subscale, the","confidence":0.9770822525024414,"confidence_rate":0.9997749336648485},{"cnt":[[146,1934],[1951,1934],[1951,1979],[146,1979]],"region":{"top_left_x":146,"top_left_y":1933,"width":1805,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"207ebee2495f4c68b3d8657585a31e50","type":"text","conversion_output":true,"text":"published MID estimate is 15 points. \\({ }^{50}\\) Assuming a two-sided alpha of 0.05 , SD of 25.6 , and true difference","text_display":" published MID estimate is 15 points. \\({ }^{50}\\) Assuming a two-sided alpha of 0.05 , SD of 25.6 , and true difference","confidence":1,"confidence_rate":1},{"cnt":[[146,1977],[1955,1977],[1955,2022],[146,2022]],"region":{"top_left_x":146,"top_left_y":1976,"width":1810,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c87f9721a74b40a49709c6d0cbd7b44c","type":"text","conversion_output":true,"text":"in mean change from baseline in UDI-irritative scores at 1 year between treatment groups of 15,92 women","text_display":" in mean change from baseline in UDI-irritative scores at 1 year between treatment groups of 15,92 women","confidence":0.9820370993540622,"confidence_rate":0.9998410109562527},{"cnt":[[146,2022],[776,2022],[776,2067],[146,2067]],"region":{"top_left_x":146,"top_left_y":2021,"width":630,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"226e5a6811e94f5cbee1206be6329a06","type":"text","conversion_output":true,"text":"per group would provide \\(90 \\%\\) power.","text_display":" per group would provide \\(90 \\%\\) power.","confidence":1,"confidence_rate":1},{"cnt":[[271,2067],[1888,2067],[1888,2112],[271,2112]],"region":{"top_left_x":270,"top_left_y":2066,"width":1619,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a81bcdde34d4f9da1e0a98c1e961623","type":"text","conversion_output":true,"text":"iii. Secondary outcome: SUI symptoms = UDI-stress subscale: For the UDI-stress subscale, the","text_display":"\niii. Secondary outcome: SUI symptoms = UDI-stress subscale: For the UDI-stress subscale, the","confidence":0.92724609375,"confidence_rate":0.9992215786391103},{"cnt":[[146,2110],[1919,2110],[1919,2155],[146,2155]],"region":{"top_left_x":146,"top_left_y":2109,"width":1773,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec0d1fc70b3e47569698f120923123c7","type":"text","conversion_output":true,"text":"published MID is 8 points. \\({ }^{51}\\) Assuming a two-sided alpha of 0.05 , SD of 21.5 , and true difference in mean","text_display":" published MID is 8 points. \\({ }^{51}\\) Assuming a two-sided alpha of 0.05 , SD of 21.5 , and true difference in mean","confidence":1,"confidence_rate":1},{"cnt":[[146,2155],[1953,2155],[1953,2198],[146,2198]],"region":{"top_left_x":146,"top_left_y":2154,"width":1807,"height":44},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"359ddab770ad4a6590d1496fd5f45e6a","type":"text","conversion_output":true,"text":"change from baseline in UDI-stress scores at 1 year between treatment groups of 8,200 women per group","text_display":" change from baseline in UDI-stress scores at 1 year between treatment groups of 8,200 women per group","confidence":0.8914827521587299,"confidence_rate":0.9989749080084914},{"cnt":[[146,2196],[1624,2196],[1624,2241],[146,2241]],"region":{"top_left_x":146,"top_left_y":2195,"width":1479,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8de81fa3c9ba46ad9641aab576a4ab91","type":"text","conversion_output":true,"text":"would provide \\(90 \\%\\) power to detect a statistically significant difference between groups.","text_display":" would provide \\(90 \\%\\) power to detect a statistically significant difference between groups.","confidence":1,"confidence_rate":1},{"cnt":[[271,2286],[1951,2286],[1951,2331],[271,2331]],"region":{"top_left_x":270,"top_left_y":2285,"width":1681,"height":47},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a316ac75f38446caf96493129d46370","type":"text","conversion_output":true,"text":"Using 200 per group as our base estimate and adjusting for \\(15 \\%\\) dropout post-operatively results in","text_display":"\n\nUsing 200 per group as our base estimate and adjusting for \\(15 \\%\\) dropout post-operatively results in","confidence":0.8804292678833008,"confidence_rate":0.9988323731611194},{"cnt":[[146,2329],[1021,2329],[1021,2374],[146,2374]],"region":{"top_left_x":146,"top_left_y":2328,"width":875,"height":47},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6007404b65d44edd8e6c47bcdc50eedb","type":"text","conversion_output":true,"text":"a total sample size of 472 randomized to treatment.","text_display":" a total sample size of 472 randomized to treatment.","confidence":1,"confidence_rate":1},{"cnt":[[271,2374],[1934,2374],[1934,2417],[271,2417]],"region":{"top_left_x":270,"top_left_y":2374,"width":1664,"height":43},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a1210a0a8a74ea0a6f6bad2ce34712b","type":"text","conversion_output":true,"text":"Additionally, this sample size will provide approximately \\(90 \\%\\) power to detect a difference as small","text_display":"\n\nAdditionally, this sample size will provide approximately \\(90 \\%\\) power to detect a difference as small","confidence":0.99365234375,"confidence_rate":0.9999404887962572},{"cnt":[[146,2417],[1944,2417],[1944,2460],[146,2460]],"region":{"top_left_x":146,"top_left_y":2416,"width":1799,"height":44},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6858492b3964fd195cb52a13de0e179","type":"text","conversion_output":true,"text":"as 19 between treatment groups for the UDI-total score, and a difference as small as 16.5 points with \\(80 \\%\\)","text_display":" as 19 between treatment groups for the UDI-total score, and a difference as small as 16.5 points with \\(80 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Potential limitations of the UDI and primary outcome:","text_display":"\n\n\\subsection*{6.1.2. Potential limitations of the UDI and primary outcome:}","confidence":0.99951171875,"confidence_rate":0.9999924861744118},{"cnt":[[271,400],[1906,400],[1906,443],[271,443]],"region":{"top_left_x":270,"top_left_y":399,"width":1636,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7d7677263e141d9b918ee12c82a9de4","type":"text","conversion_output":true,"text":"One potential limitation of using change from baseline score as the primary outcome is that point","text_display":"\n\nOne potential limitation of using change from baseline score as the primary outcome is that point","confidence":1,"confidence_rate":1},{"cnt":[[146,443],[1959,443],[1959,488],[146,488]],"region":{"top_left_x":146,"top_left_y":442,"width":1814,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0497a1e1a6334b53bf6440b63347bb16","type":"text","conversion_output":true,"text":"estimates of the difference in means between 2 groups may mask important changes for individual patients","text_display":" estimates of the difference in means between 2 groups may mask important changes for individual patients","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[146,488],[1923,488],[1923,531],[146,531]],"region":{"top_left_x":146,"top_left_y":487,"width":1777,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32c59220b7ff4ff09ae19442a7247ef3","type":"text","conversion_output":true,"text":"that are meaningful. However, this would also be the case if we dichotomized the outcome into \"success\"","text_display":" that are meaningful. However, this would also be the case if we dichotomized the outcome into \"success\"","confidence":1,"confidence_rate":1},{"cnt":[[146,533],[1916,533],[1916,576],[146,576]],"region":{"top_left_x":146,"top_left_y":532,"width":1771,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"765286752fa74ab49b0bcc241fd7e608","type":"text","conversion_output":true,"text":"versus \"failure\". In addition, the published MID used for our primary outcome is derived from the BE-DRI","text_display":" versus \"failure\". In addition, the published MID used for our primary outcome is derived from the BE-DRI","confidence":1,"confidence_rate":1},{"cnt":[[146,576],[1865,576],[1865,621],[146,621]],"region":{"top_left_x":146,"top_left_y":575,"width":1719,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31ff21c34a1e4be5892f0e88aa49c60f","type":"text","conversion_output":true,"text":"population, an urge-predominant MUI population and MID estimates can vary depending on the study","text_display":" population, an urge-predominant MUI population and MID estimates can vary depending on the study","confidence":1,"confidence_rate":1},{"cnt":[[146,619],[1893,619],[1893,664],[146,664]],"region":{"top_left_x":146,"top_left_y":618,"width":1747,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0051cea24364c83a23565494fc3f8f9","type":"text","conversion_output":true,"text":"population. The published estimate for UDI-total MID for the BE-DRI urge-predominant population is 35","text_display":" population. The published estimate for UDI-total MID for the BE-DRI urge-predominant population is 35","confidence":1,"confidence_rate":1},{"cnt":[[146,662],[1833,662],[1833,707],[146,707]],"region":{"top_left_x":146,"top_left_y":661,"width":1687,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d77c38cb21fc4c58a27ba6c4c780c930","type":"text","conversion_output":true,"text":"points based on Dyer et al \\({ }^{50}\\) whereas Barber et al found the MID for pure stress/stress-predominant","text_display":" points based on Dyer et al \\({ }^{50}\\) whereas Barber et al found the MID for pure stress/stress-predominant","confidence":0.9741334915161133,"confidence_rate":0.9997701410726113},{"cnt":[[146,705],[1953,705],[1953,750],[146,750]],"region":{"top_left_x":146,"top_left_y":704,"width":1807,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e58253c36d104c2db8c25b2b1749ed8b","type":"text","conversion_output":true,"text":"population to be 11 points in the ATLAS population. \\({ }^{51}\\) One advantage of the BE-DRI population is that \\(96 \\%\\)","text_display":" population to be 11 points in the ATLAS population. \\({ }^{51}\\) One advantage of the BE-DRI population is that \\(96 \\%\\)","confidence":0.99853515625,"confidence_rate":0.9999879843534795},{"cnt":[[146,752],[1921,752],[1921,793],[146,793]],"region":{"top_left_x":146,"top_left_y":751,"width":1775,"height":42},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"001ea519614d40b5bb7099483e4b5fd1","type":"text","conversion_output":true,"text":"had MUI, which is more similar to the anticipated ESTEEM population. It is possible that women with UUI","text_display":" had MUI, which is more similar to the anticipated ESTEEM population. It is possible that women with UUI","confidence":1,"confidence_rate":1},{"cnt":[[146,795],[1794,795],[1794,838],[146,838]],"region":{"top_left_x":146,"top_left_y":794,"width":1648,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff7e9ea08285485d83a86f7bda83f7c8","type":"text","conversion_output":true,"text":"require larger improvements compared to pure/SUI predominant women to be meaningful. This is","text_display":" require larger improvements compared to pure/SUI predominant women to be meaningful. This is","confidence":1,"confidence_rate":1},{"cnt":[[146,838],[1936,838],[1936,883],[146,883]],"region":{"top_left_x":146,"top_left_y":837,"width":1790,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"723a86cd79884759a9225351f2ab6ea0","type":"text","conversion_output":true,"text":"consistent with many previous studies showing that women with UUI experience worse impact and bother","text_display":" consistent with many previous studies showing that women with UUI experience worse impact and bother","confidence":1,"confidence_rate":1},{"cnt":[[146,883],[1910,883],[1910,926],[146,926]],"region":{"top_left_x":146,"top_left_y":883,"width":1764,"height":43},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d363a078f286410391d486c23f8dbfcb","type":"text","conversion_output":true,"text":"than SUI patients and that the UUI component drives patient perception of severity and satisfaction after","text_display":" than SUI patients and that the UUI component drives patient perception of severity and satisfaction after","confidence":1,"confidence_rate":1},{"cnt":[[146,928],[322,928],[322,965],[146,965]],"region":{"top_left_x":146,"top_left_y":928,"width":177,"height":37},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4718babc84114963957134dc2fdc9c50","type":"text","conversion_output":true,"text":"treatment.","text_display":" treatment.","confidence":1,"confidence_rate":1},{"cnt":[[271,971],[1882,971],[1882,1016],[271,1016]],"region":{"top_left_x":270,"top_left_y":971,"width":1613,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"938e95cd8167460cb818d5a6d5776162","type":"text","conversion_output":true,"text":"Although we do not definitively know whether 35 is an accurate MID for determining success or","text_display":"\n\nAlthough we do not definitively know whether 35 is an accurate MID for determining success or","confidence":1,"confidence_rate":1},{"cnt":[[146,1014],[1940,1014],[1940,1059],[146,1059]],"region":{"top_left_x":146,"top_left_y":1014,"width":1795,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f85b15f2d9424b9f982c4b51108bc856","type":"text","conversion_output":true,"text":"failure in this study population, we consider this MID estimate from BE-DRI to be the published MID that is","text_display":" failure in this study population, we consider this MID estimate from BE-DRI to be the published MID that is","confidence":1,"confidence_rate":1},{"cnt":[[146,1059],[1940,1059],[1940,1102],[146,1102]],"region":{"top_left_x":146,"top_left_y":1059,"width":1795,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c881b30493194e2399cbd0aff2190a21","type":"text","conversion_output":true,"text":"most applicable to our target population. In addition, because our total sample size is 400 subjects (before","text_display":" most applicable to our target population. In addition, because our total sample size is 400 subjects (before","confidence":0.9990236759185791,"confidence_rate":0.9999915793372107},{"cnt":[[146,1104],[1970,1104],[1970,1145],[146,1145]],"region":{"top_left_x":146,"top_left_y":1104,"width":1825,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc7eee4eb22d4368a543d13d122a51c9","type":"text","conversion_output":true,"text":"adjustment for drop out), our study will have \\(90 \\%\\) power to detect a statistically significant difference in UDI-","text_display":" adjustment for drop out), our study will have \\(90 \\%\\) power to detect a statistically significant difference in UDI","confidence":1,"confidence_rate":1},{"cnt":[[146,1147],[1850,1147],[1850,1190],[146,1190]],"region":{"top_left_x":146,"top_left_y":1147,"width":1704,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"946b10ad0e9642f598c97530ac71873e","type":"text","conversion_output":true,"text":"total scores if the true difference is as small as 19 points between groups and \\(80 \\%\\) power to detect a","text_display":"total scores if the true difference is as small as 19 points between groups and \\(80 \\%\\) power to detect a","confidence":0.9975605006329715,"confidence_rate":0.9999781923824881},{"cnt":[[146,1190],[1931,1190],[1931,1231],[146,1231]],"region":{"top_left_x":146,"top_left_y":1190,"width":1786,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d1d7f027a484ca6a835991649ac2e36","type":"text","conversion_output":true,"text":"difference if the true difference is as small as 16.5 points. This difference is smaller than the conservative,","text_display":" difference if the true difference is as small as 16.5 points. This difference is smaller than the conservative,","confidence":0.9985356330871582,"confidence_rate":0.9999876854527495},{"cnt":[[146,1233],[1927,1233],[1927,1278],[146,1278]],"region":{"top_left_x":146,"top_left_y":1233,"width":1782,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2690b299975d4aa2afb7babb999d76c4","type":"text","conversion_output":true,"text":"distribution-based MID estimate of -24.8 based on the BE-DRI population. Thus, the planned sample size","text_display":" distribution-based MID estimate of -24.8 based on the BE-DRI population. Thus, the planned sample size","confidence":0.99853515625,"confidence_rate":0.9999866735644114},{"cnt":[[146,1276],[1674,1276],[1674,1321],[146,1321]],"region":{"top_left_x":146,"top_left_y":1276,"width":1528,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c57fc2df08924297aa2e2248fe8d9bdb","type":"text","conversion_output":true,"text":"will allow for analyses to assess whether the true MID in this population is smaller than 35 .","text_display":" will allow for analyses to assess whether the true MID in this population is smaller than 35 .","confidence":0.7115664482116699,"confidence_rate":0.9966694168352677},{"cnt":[[271,1319],[1901,1319],[1901,1364],[271,1364]],"region":{"top_left_x":270,"top_left_y":1319,"width":1632,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd0cac1d62574c84af05b0a15b0cc445","type":"text","conversion_output":true,"text":"Finally, the UDI total score includes 3 subscales: stress, irritative and obstructive. Therefore, our","text_display":"\n\nFinally, the UDI total score includes 3 subscales: stress, irritative and obstructive. Therefore, our","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[146,1366],[1923,1366],[1923,1412],[146,1412]],"region":{"top_left_x":146,"top_left_y":1366,"width":1777,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16aecda75eb4408aae27630c0137a413","type":"text","conversion_output":true,"text":"primary outcome will include a total score combining all 3 of these subscales. We believe the inclusion of","text_display":" primary outcome will include a total score combining all 3 of these subscales. We believe the inclusion of","confidence":1,"confidence_rate":1},{"cnt":[[146,1409],[1240,1409],[1240,1454],[146,1454]],"region":{"top_left_x":146,"top_left_y":1409,"width":1094,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d05b4eff020047e18d440a80f3c48d61","type":"text","conversion_output":true,"text":"the obstructive subscale is appropriate for the following reasons:","text_display":" the obstructive subscale is appropriate for the following reasons:","confidence":0.98486328125,"confidence_rate":0.9997851998586968},{"cnt":[[275,1452],[1910,1452],[1910,1497],[275,1497]],"region":{"top_left_x":275,"top_left_y":1452,"width":1635,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c63d6b45ade247c2be5235e6017ed6cf","type":"text","conversion_output":true,"text":"1. Although obstructive symptoms related to prolapse are not a focus of ESTEEM, some items in","text_display":"\n1. Although obstructive symptoms related to prolapse are not a focus of ESTEEM, some items in","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[146,1497],[1916,1497],[1916,1540],[146,1540]],"region":{"top_left_x":146,"top_left_y":1497,"width":1771,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91d1f33d0dbc48c5bb796be4db31a53f","type":"text","conversion_output":true,"text":"this subscale may still be relevant to the MUI population (ie: \"general urine leakage not related to urge or","text_display":" this subscale may still be relevant to the MUI population (ie: \"general urine leakage not related to urge or","confidence":1,"confidence_rate":1},{"cnt":[[146,1543],[1351,1543],[1351,1588],[146,1588]],"region":{"top_left_x":146,"top_left_y":1542,"width":1206,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf4700c7956b4a4f8b9b44f92566ceb6","type":"text","conversion_output":true,"text":"activity\"; symptoms of \"difficulty emptying\"; and \"incomplete emptying\").","text_display":" activity\"; symptoms of \"difficulty emptying\"; and \"incomplete emptying\").","confidence":1,"confidence_rate":1},{"cnt":[[271,1586],[1949,1586],[1949,1631],[271,1631]],"region":{"top_left_x":270,"top_left_y":1585,"width":1679,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11dc23c604e14f9faa39ff2cf8cc1762","type":"text","conversion_output":true,"text":"2. Because women with symptomatic prolapse will be excluded in both groups, it is unlikely that the","text_display":"\n2. Because women with symptomatic prolapse will be excluded in both groups, it is unlikely that the","confidence":1,"confidence_rate":1},{"cnt":[[146,1629],[1253,1629],[1253,1674],[146,1674]],"region":{"top_left_x":146,"top_left_y":1628,"width":1107,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd543cbd84b94f17b54cf4d8d22aecdc","type":"text","conversion_output":true,"text":"inclusion of this subscale in the primary outcome will lead to bias.","text_display":" inclusion of this subscale in the primary outcome will lead to bias.","confidence":1,"confidence_rate":1},{"cnt":[[271,1674],[1966,1674],[1966,1717],[271,1717]],"region":{"top_left_x":270,"top_left_y":1673,"width":1696,"height":44},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e69651ee96724857a26182afc8b37628","type":"text","conversion_output":true,"text":"3. The published MID for the UDI in the BE-DRI population also includes all 3 subscales for an urge-","text_display":"\n3. The published MID for the UDI in the BE-DRI population also includes all 3 subscales for an urge","confidence":1,"confidence_rate":1},{"cnt":[[146,1714],[672,1714],[672,1760],[146,1760]],"region":{"top_left_x":146,"top_left_y":1714,"width":527,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be46be52be444d3991557ab35f18515a","type":"text","conversion_output":true,"text":"predominant MUI population. \\({ }^{50}\\)","text_display":"predominant MUI population. \\({ }^{50}\\)","confidence":1,"confidence_rate":1},{"cnt":[[142,1843],[1280,1843],[1280,1893],[142,1893]],"region":{"top_left_x":141,"top_left_y":1843,"width":1140,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f367c267b3142bdb62d964f8970ccc8","type":"section_header","conversion_output":false,"children_ids":["0d161c2a4c394cab8b2151fc3521c344"],"text":"","text_display":""},{"cnt":[[146,1848],[1278,1848],[1278,1888],[146,1888]],"region":{"top_left_x":146,"top_left_y":1847,"width":1133,"height":42},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d161c2a4c394cab8b2151fc3521c344","type":"text","conversion_output":true,"parent_id":"6f367c267b3142bdb62d964f8970ccc8","text":"6.1.3. Management of women who drop out prior to receiving MUS","text_display":"\n\n\\subsection*{6.1.3. Management of women who drop out prior to receiving MUS}","confidence":0.99951171875,"confidence_rate":0.9999927104668955},{"cnt":[[271,1899],[1876,1899],[1876,1944],[271,1944]],"region":{"top_left_x":270,"top_left_y":1899,"width":1606,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8149bc4bb06044f5afda6cd8838275b2","type":"text","conversion_output":true,"text":"It is possible that some women in both groups may cancel their surgical MUS procedure due to","text_display":"\n\nIt is possible that some women in both groups may cancel their surgical MUS procedure due to","confidence":1,"confidence_rate":1},{"cnt":[[146,1944],[1906,1944],[1906,1987],[146,1987]],"region":{"top_left_x":146,"top_left_y":1944,"width":1760,"height":44},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dd0377e7c6e49cf8b4c20b43c3cf49f","type":"text","conversion_output":true,"text":"personal reasons, or other. It is also possible that women randomized to BPTx may cancel their surgical","text_display":" personal reasons, or other. It is also possible that women randomized to BPTx may cancel their surgical","confidence":1,"confidence_rate":1},{"cnt":[[146,1989],[1962,1989],[1962,2032],[146,2032]],"region":{"top_left_x":146,"top_left_y":1989,"width":1816,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20bd8f8c9ab34dec91ee57ac5dda39c0","type":"text","conversion_output":true,"text":"procedure if they receive preoperative BPTx treatment and experience improvement. These women will still","text_display":" procedure if they receive preoperative BPTx treatment and experience improvement. These women will still","confidence":1,"confidence_rate":1},{"cnt":[[146,2032],[771,2032],[771,2078],[146,2078]],"region":{"top_left_x":146,"top_left_y":2032,"width":626,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c7fc206cffc494fba1a5a45940ce76a","type":"text","conversion_output":true,"text":"be included from an ITT perspective.","text_display":" be included from an ITT perspective.","confidence":1,"confidence_rate":1},{"cnt":[[144,2116],[625,2116],[625,2163],[144,2163]],"region":{"top_left_x":143,"top_left_y":2116,"width":483,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d41864d6fc114531ae58d1a552209174","type":"section_header","conversion_output":false,"children_ids":["633f9d98d9d4436d8ff60d9dbaff1052"],"text":"","text_display":""},{"cnt":[[146,2118],[621,2118],[621,2161],[146,2161]],"region":{"top_left_x":146,"top_left_y":2118,"width":475,"height":44},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"633f9d98d9d4436d8ff60d9dbaff1052","type":"text","conversion_output":true,"parent_id":"d41864d6fc114531ae58d1a552209174","text":"6.2. Statistical analysis plan","text_display":"\n\n\\subsection*{6.2. Statistical analysis plan}","confidence":0.99951171875,"confidence_rate":0.9999860457974148},{"cnt":[[142,2256],[466,2256],[466,2305],[142,2305]],"region":{"top_left_x":141,"top_left_y":2255,"width":326,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e87c7435f83430992e29d1f54658f76","type":"section_header","conversion_output":false,"children_ids":["b2b3c455b50f4e8a8dcdc8633111891f"],"text":"","text_display":""},{"cnt":[[146,2260],[462,2260],[462,2301],[146,2301]],"region":{"top_left_x":146,"top_left_y":2260,"width":316,"height":41},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2b3c455b50f4e8a8dcdc8633111891f","type":"text","conversion_output":true,"parent_id":"9e87c7435f83430992e29d1f54658f76","text":"6.2.1. Primary aim","text_display":"\n\n\\subsection*{6.2.1. Primary aim}","confidence":1,"confidence_rate":1},{"cnt":[[271,2312],[1869,2312],[1869,2357],[271,2357]],"region":{"top_left_x":270,"top_left_y":2311,"width":1600,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1b7d216050b4695bbefb0f8f50c412a","type":"text","conversion_output":true,"text":"The mean change from baseline in UDI scores will be compared between groups at 1 year. As","text_display":"\n\nThe mean change from baseline in UDI scores will be compared between groups at 1 year. As","confidence":0.9990236759185791,"confidence_rate":0.9999899299373404},{"cnt":[[146,2357],[1940,2357],[1940,2400],[146,2400]],"region":{"top_left_x":146,"top_left_y":2356,"width":1795,"height":44},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f300ccf59358450eaf6c62fb0a943eb9","type":"text","conversion_output":true,"text":"explained previously, participants will be permitted to seek additional treatment for SUI and/or OAB after 3","text_display":" explained previously, participants will be permitted to seek additional treatment for SUI and/or OAB after 3","confidence":1,"confidence_rate":1},{"cnt":[[146,2400],[1962,2400],[1962,2445],[146,2445]],"region":{"top_left_x":146,"top_left_y":2399,"width":1816,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4f4552d348a4ce08789a1131bf9da73","type":"text","conversion_output":true,"text":"months following MUS. Because such treatment is expected to impact the participant's UDI score at 1 year,","text_display":" months following MUS. Because such treatment is expected to impact the participant's UDI score at 1 year,","confidence":0.99658203125,"confidence_rate":0.9999697011373423},{"cnt":[[146,2445],[1938,2445],[1938,2490],[146,2490]],"region":{"top_left_x":146,"top_left_y":2444,"width":1792,"height":47},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d555d8989884702ae71505bc0eca873","type":"text","conversion_output":true,"text":"we will use an analysis method that accounts for the impact of additional treatment. Specifically, a general","text_display":" we will use an analysis method that accounts for the impact of additional treatment. Specifically, a general","confidence":1,"confidence_rate":1},{"cnt":[[146,2488],[1957,2488],[1957,2533],[146,2533]],"region":{"top_left_x":146,"top_left_y":2487,"width":1812,"height":47},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"025de280a55644cfa46f9f7376cb8565","type":"text","conversion_output":true,"text":"linear mixed model will be constructed to model change from baseline in UDI scores using scores recorded","text_display":" linear mixed model will be constructed to model change from baseline in UDI scores using scores recorded","confidence":1,"confidence_rate":1},{"cnt":[[1036,2548],[1083,2548],[1083,2593],[1036,2593]],"region":{"top_left_x":1035,"top_left_y":2548,"width":48,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29063ff5c3a14e0883b25a5df55b4cc9","type":"page_info","conversion_output":false,"text":"41","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0c14e6b8f0e4caabec4b91aaea4d612","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-42","page":42,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"885110a5bd12450eb4b5f9a5429674a4","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57ae45210a6944b3a2c3036f7b360c3f","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7efa52426024ae5871020ee389691d6","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,254],[146,254]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":40},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2872a49a258341bba7555787b4fb3098","type":"section_header","conversion_output":false,"children_ids":["647ed6f77a154bfdb7064371eabfe243"],"text":"","text_display":""},{"cnt":[[148,215],[354,215],[354,251],[148,251]],"region":{"top_left_x":148,"top_left_y":214,"width":207,"height":38},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"647ed6f77a154bfdb7064371eabfe243","type":"text","conversion_output":true,"parent_id":"2872a49a258341bba7555787b4fb3098","text":"Confidential","text_display":"\n\n\\section*{Confidential}","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1863,260],[1863,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1717,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"741b2f65d48c42ed808f8d4b3b70e2d8","type":"text","conversion_output":true,"text":"at time points up to 1 year following MUS. For participants who request additional treatment, only UDI","text_display":"\nat time points up to 1 year following MUS. For participants who request additional treatment, only UDI","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[146,305],[1974,305],[1974,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1829,"height":41},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19774680bccb48878d7fcf5a45454f7e","type":"text","conversion_output":true,"text":"measurements up to the time of additional treatment will be included in the model, and measurements taken","text_display":" measurements up to the time of additional treatment will be included in the model, and measurements taken","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[1957,348],[1957,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1812,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4af2cd8235214bfd9f7a5a8979049f86","type":"text","conversion_output":true,"text":"between additional treatment and 1 year will be considered missing for the purpose of the primary analysis.","text_display":" between additional treatment and 1 year will be considered missing for the purpose of the primary analysis.","confidence":0.998046875,"confidence_rate":0.9999829998415843},{"cnt":[[146,391],[1807,391],[1807,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1661,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"863250eb42f9468cadb24e64cd4ef86e","type":"text","conversion_output":true,"text":"The model will include fixed effects for treatment group, time, request for additional treatment, and","text_display":" The model will include fixed effects for treatment group, time, request for additional treatment, and","confidence":1,"confidence_rate":1},{"cnt":[[146,434],[1957,434],[1957,479],[146,479]],"region":{"top_left_x":146,"top_left_y":433,"width":1812,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa3057344b4c455b860c960e59802b2b","type":"text","conversion_output":true,"text":"interactions between those variables. It will also be adjusted for the design effects of stratification by center","text_display":" interactions between those variables. It will also be adjusted for the design effects of stratification by center","confidence":0.9990234375,"confidence_rate":0.9999917200372636},{"cnt":[[146,479],[1906,479],[1906,522],[146,522]],"region":{"top_left_x":146,"top_left_y":479,"width":1760,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0819f355d7bc4109b7091a188c988e19","type":"text","conversion_output":true,"text":"and by baseline urge IE group. Thus, the models will allow for different trajectories of change for women","text_display":" and by baseline urge IE group. Thus, the models will allow for different trajectories of change for women","confidence":1,"confidence_rate":1},{"cnt":[[146,524],[1880,524],[1880,567],[146,567]],"region":{"top_left_x":146,"top_left_y":524,"width":1734,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69360537a3964daf8c049ec6509b5ccb","type":"text","conversion_output":true,"text":"who are or are not randomized to BPTx and for those who do or do not request additional treatment. A","text_display":" who are or are not randomized to BPTx and for those who do or do not request additional treatment. A","confidence":1,"confidence_rate":1},{"cnt":[[146,567],[1966,567],[1966,612],[146,612]],"region":{"top_left_x":146,"top_left_y":567,"width":1820,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58653f77fd914522912594e1900a31c7","type":"text","conversion_output":true,"text":"statistical test based on the model will be conducted to assess whether mean changes from baseline in UDI","text_display":" statistical test based on the model will be conducted to assess whether mean changes from baseline in UDI","confidence":1,"confidence_rate":1},{"cnt":[[146,610],[1944,610],[1944,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1799,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"391d7eda7c8b41f7aff4443386e96dfa","type":"text","conversion_output":true,"text":"scores at 1 year are significantly different between the two treatment groups, accounting for the percent of","text_display":" scores at 1 year are significantly different between the two treatment groups, accounting for the percent of","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[1906,655],[1906,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1760,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51c18246c7e24532a9c4265cd1eadf95","type":"text","conversion_output":true,"text":"women in each group who request additional treatment. Sensitivity analysis will be conducted to test the","text_display":" women in each group who request additional treatment. Sensitivity analysis will be conducted to test the","confidence":1,"confidence_rate":1},{"cnt":[[146,700],[982,700],[982,741],[146,741]],"region":{"top_left_x":146,"top_left_y":700,"width":836,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54ea0154278943139a7f9477597951ca","type":"text","conversion_output":true,"text":"robustness of test results to model specifications.","text_display":" robustness of test results to model specifications.","confidence":1,"confidence_rate":1},{"cnt":[[271,743],[1884,743],[1884,786],[271,786]],"region":{"top_left_x":270,"top_left_y":743,"width":1615,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"233a003a55ed427ead0704f2a1961994","type":"text","conversion_output":true,"text":"We will report whether change in total UDI score between baseline and one year is significantly","text_display":"\n\nWe will report whether change in total UDI score between baseline and one year is significantly","confidence":1,"confidence_rate":1},{"cnt":[[146,786],[1962,786],[1962,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1816,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e285735c30d44efac4724753249e581","type":"text","conversion_output":true,"text":"different in the two groups. If the difference is statistically significant, the potential clinical significance of the","text_display":" different in the two groups. If the difference is statistically significant, the potential clinical significance of the","confidence":1,"confidence_rate":1},{"cnt":[[146,829],[1962,829],[1962,874],[146,874]],"region":{"top_left_x":146,"top_left_y":829,"width":1816,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35ca10a5122449309fa2e90428dd4dd2","type":"text","conversion_output":true,"text":"difference will be discussed. We recognize that our sample size would allow us to find a difference between","text_display":" difference will be discussed. We recognize that our sample size would allow us to find a difference between","confidence":1,"confidence_rate":1},{"cnt":[[146,872],[1897,872],[1897,917],[146,917]],"region":{"top_left_x":146,"top_left_y":872,"width":1752,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"115cafc10ab844ca98b4bba38834db2e","type":"text","conversion_output":true,"text":"groups that is statistically significant yet smaller than published MIDs for total UDI score for women with","text_display":" groups that is statistically significant yet smaller than published MIDs for total UDI score for women with","confidence":1,"confidence_rate":1},{"cnt":[[146,920],[1962,920],[1962,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1816,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74600514048f466fba53d2a2e1379080","type":"text","conversion_output":true,"text":"MUI. However, published MIDs were calculated based on populations that may be somewhat different from","text_display":" MUI. However, published MIDs were calculated based on populations that may be somewhat different from","confidence":1,"confidence_rate":1},{"cnt":[[146,962],[1972,962],[1972,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":962,"width":1827,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9aace4bcc2d9472eaf72c5e79bb70443","type":"text","conversion_output":true,"text":"the one targeted for enrollment in ESTEEM, and a secondary aim of ESTEEM is to explore whether the true","text_display":" the one targeted for enrollment in ESTEEM, and a secondary aim of ESTEEM is to explore whether the true","confidence":1,"confidence_rate":1},{"cnt":[[146,1005],[1207,1005],[1207,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1005,"width":1062,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17825228bd7f4beeb7e915b24c46fcb5","type":"text","conversion_output":true,"text":"MID in this population differs from previously published values.","text_display":" MID in this population differs from previously published values.","confidence":0.99951171875,"confidence_rate":0.9999929217569623},{"cnt":[[144,1134],[535,1134],[535,1179],[144,1179]],"region":{"top_left_x":143,"top_left_y":1134,"width":392,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29b0c31a07e743b4b6c8031dba287557","type":"section_header","conversion_output":false,"children_ids":["053193f518ec44c39befeb8d9dcf1224"],"text":"","text_display":""},{"cnt":[[146,1137],[535,1137],[535,1179],[146,1179]],"region":{"top_left_x":146,"top_left_y":1136,"width":389,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"053193f518ec44c39befeb8d9dcf1224","type":"text","conversion_output":true,"parent_id":"29b0c31a07e743b4b6c8031dba287557","text":"6.2.2. Secondary aims","text_display":"\n\n\\subsection*{6.2.2. Secondary aims}","confidence":0.9794921875,"confidence_rate":0.9992033552732118},{"cnt":[[271,1190],[1934,1190],[1934,1233],[271,1233]],"region":{"top_left_x":270,"top_left_y":1190,"width":1664,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95d867059e284e71a1052f0cff26f9ff","type":"text","conversion_output":true,"text":"The mean change from baseline in UDI-irritative and UDI-stress scores at 1 year will be compared","text_display":"\n\nThe mean change from baseline in UDI-irritative and UDI-stress scores at 1 year will be compared","confidence":0.99853515625,"confidence_rate":0.9999859047370074},{"cnt":[[146,1233],[1914,1233],[1914,1278],[146,1278]],"region":{"top_left_x":146,"top_left_y":1233,"width":1769,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"593aa9b928e34214b8865aa9b96417a4","type":"text","conversion_output":true,"text":"between groups using the same analysis methods described for the primary outcome. If the difference is","text_display":" between groups using the same analysis methods described for the primary outcome. If the difference is","confidence":1,"confidence_rate":1},{"cnt":[[146,1278],[1852,1278],[1852,1321],[146,1321]],"region":{"top_left_x":146,"top_left_y":1278,"width":1706,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7da373d9db9470eabf15824cdfa2f89","type":"text","conversion_output":true,"text":"statistically significant, the potential clinical significance of the difference will be discussed. Additional","text_display":" statistically significant, the potential clinical significance of the difference will be discussed. Additional","confidence":1,"confidence_rate":1},{"cnt":[[146,1319],[1884,1319],[1884,1366],[146,1366]],"region":{"top_left_x":146,"top_left_y":1319,"width":1739,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bc9c661700e4d0091716a5da581d616","type":"text","conversion_output":true,"text":"analyses will be conducted to determine whether the MIDs in this MUI population differ from previously","text_display":" analyses will be conducted to determine whether the MIDs in this MUI population differ from previously","confidence":1,"confidence_rate":1},{"cnt":[[146,1366],[423,1366],[423,1412],[146,1412]],"region":{"top_left_x":146,"top_left_y":1366,"width":278,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"413bbac8158945cba9594161a148ea52","type":"text","conversion_output":true,"text":"published MIDs.","text_display":" published MIDs.","confidence":1,"confidence_rate":1},{"cnt":[[144,1491],[546,1491],[546,1540],[144,1540]],"region":{"top_left_x":143,"top_left_y":1491,"width":403,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"764361a533634245a6d7e275e7a483b5","type":"section_header","conversion_output":false,"children_ids":["c2ea952758d249fd8396171169ba161c"],"text":"","text_display":""},{"cnt":[[146,1495],[544,1495],[544,1538],[146,1538]],"region":{"top_left_x":146,"top_left_y":1495,"width":398,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2ea952758d249fd8396171169ba161c","type":"text","conversion_output":true,"parent_id":"764361a533634245a6d7e275e7a483b5","text":"6.2.3. Exploratory aims","text_display":"\n\n\\subsection*{6.2.3. Exploratory aims}","confidence":0.99853515625,"confidence_rate":0.9999476471675111},{"cnt":[[146,1547],[649,1547],[649,1590],[146,1590]],"region":{"top_left_x":146,"top_left_y":1546,"width":503,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80b31ee1167a482e8cb69fad8563b086","type":"section_header","conversion_output":false,"children_ids":["ec6662177dcd4bd8b53a92b34c92e790"],"text":"","text_display":""},{"cnt":[[148,1551],[647,1551],[647,1588],[148,1588]],"region":{"top_left_x":148,"top_left_y":1551,"width":499,"height":37},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec6662177dcd4bd8b53a92b34c92e790","type":"text","conversion_output":true,"parent_id":"80b31ee1167a482e8cb69fad8563b086","text":"a. Other UUI/OAB outcomes","text_display":"\n\n\\section*{a. Other UUI/OAB outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[271,1592],[509,1592],[509,1639],[271,1639]],"region":{"top_left_x":270,"top_left_y":1591,"width":240,"height":49},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1779c0e642549f894604b3caf3170df","type":"section_header","conversion_output":false,"children_ids":["51dea973657b4a5687a3b11b46f29d2a"],"text":"","text_display":""},{"cnt":[[271,1594],[505,1594],[505,1635],[271,1635]],"region":{"top_left_x":270,"top_left_y":1594,"width":235,"height":41},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51dea973657b4a5687a3b11b46f29d2a","type":"text","conversion_output":true,"parent_id":"a1779c0e642549f894604b3caf3170df","text":"Bladder diary","text_display":"\n\n\\section*{Bladder diary}","confidence":1,"confidence_rate":1},{"cnt":[[271,1637],[1841,1637],[1841,1682],[271,1682]],"region":{"top_left_x":270,"top_left_y":1637,"width":1572,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1c403b665684b31bb2dad9b6e538c58","type":"text","conversion_output":true,"text":"We will compare change in number of urge IEs and urgency-episodes and nocturia episodes","text_display":"\n\nWe will compare change in number of urge IEs and urgency-episodes and nocturia episodes","confidence":1,"confidence_rate":1},{"cnt":[[146,1680],[1867,1680],[1867,1725],[146,1725]],"region":{"top_left_x":146,"top_left_y":1680,"width":1721,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9309c3e6b2e04632917b7e56831429ed","type":"text","conversion_output":true,"text":"between groups from baseline to 6 and 12 months. Of note, not all four symptoms of OAB (frequency,","text_display":" between groups from baseline to 6 and 12 months. Of note, not all four symptoms of OAB (frequency,","confidence":0.9497785568237305,"confidence_rate":0.999552044539069},{"cnt":[[146,1725],[1861,1725],[1861,1770],[146,1770]],"region":{"top_left_x":146,"top_left_y":1725,"width":1715,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"728f4c45ddcc486c959cce9219db2f85","type":"text","conversion_output":true,"text":"urgency, nocturia, and UUI) are required to be present at baseline for eligibility into this trial (only UUI","text_display":" urgency, nocturia, and UUI) are required to be present at baseline for eligibility into this trial (only UUI","confidence":1,"confidence_rate":1},{"cnt":[[146,1770],[1880,1770],[1880,1815],[146,1815]],"region":{"top_left_x":146,"top_left_y":1770,"width":1734,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8045b4a8b374d0fa5676213a19c0d74","type":"text","conversion_output":true,"text":"required). Changes from baseline in bladder diary outcomes will be calculated and analyzed using the","text_display":" required). Changes from baseline in bladder diary outcomes will be calculated and analyzed using the","confidence":1,"confidence_rate":1},{"cnt":[[146,1813],[1154,1813],[1154,1858],[146,1858]],"region":{"top_left_x":146,"top_left_y":1813,"width":1008,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"360a89e87154494999800cdecc79e2f3","type":"text","conversion_output":true,"text":"methods described for the analysis of the primary outcome.","text_display":" methods described for the analysis of the primary outcome.","confidence":1,"confidence_rate":1},{"cnt":[[271,1856],[1970,1856],[1970,1901],[271,1901]],"region":{"top_left_x":270,"top_left_y":1856,"width":1701,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29ed237c50af49e3a4146fe4a20ab355","type":"text","conversion_output":true,"text":"For urinary frequency, women reporting on average \\(>8\\) voids \\(/ 24\\) hours at baseline will be considered","text_display":"\n\nFor urinary frequency, women reporting on average \\(>8\\) voids \\(/ 24\\) hours at baseline will be considered","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[146,1899],[1962,1899],[1962,1944],[146,1944]],"region":{"top_left_x":146,"top_left_y":1899,"width":1816,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a42d4072edeb44e5b60ca8ae2230f469","type":"text","conversion_output":true,"text":"symptomatic, and normalization of voiding frequency will be defined as \\(\\leq 8\\) voids \\(/ 24\\) hours at 1 year. A \\(50 \\%\\)","text_display":" symptomatic, and normalization of voiding frequency will be defined as \\(\\leq 8\\) voids \\(/ 24\\) hours at 1 year. A \\(50 \\%\\)","confidence":0.9902429580688477,"confidence_rate":0.9999176088248318},{"cnt":[[146,1944],[1972,1944],[1972,1987],[146,1987]],"region":{"top_left_x":146,"top_left_y":1944,"width":1827,"height":44},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90959da2110b453fa662cdeeb0b3db90","type":"text","conversion_output":true,"text":"improvement will be defined as a reduction by half in the number of voids that patients had at baseline. The","text_display":" improvement will be defined as a reduction by half in the number of voids that patients had at baseline. The","confidence":1,"confidence_rate":1},{"cnt":[[146,1987],[1893,1985],[1893,2032],[146,2035]],"region":{"top_left_x":146,"top_left_y":1985,"width":1747,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f11b069aa1064774910dd059859ba894","type":"text","conversion_output":true,"text":"number of women who had normalization of voiding frequency and \\(50 \\%\\) improvement will be compared","text_display":" number of women who had normalization of voiding frequency and \\(50 \\%\\) improvement will be compared","confidence":1,"confidence_rate":1},{"cnt":[[146,2032],[1811,2032],[1811,2078],[146,2078]],"region":{"top_left_x":146,"top_left_y":2032,"width":1666,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a3e6862666046e6824b930856149d4d","type":"text","conversion_output":true,"text":"between groups separately and collectively. We will also assess the proportion of women who had","text_display":" between groups separately and collectively. We will also assess the proportion of women who had","confidence":1,"confidence_rate":1},{"cnt":[[146,2075],[1824,2075],[1824,2121],[146,2121]],"region":{"top_left_x":146,"top_left_y":2075,"width":1679,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bcc32b1f1094fdb9379bc6cae69a7ad","type":"text","conversion_output":true,"text":"worsening of urinary frequency (includes women who developed de novo frequency and those who","text_display":" worsening of urinary frequency (includes women who developed de novo frequency and those who","confidence":1,"confidence_rate":1},{"cnt":[[146,2121],[1876,2121],[1876,2166],[146,2166]],"region":{"top_left_x":146,"top_left_y":2120,"width":1730,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddffe9b45c264ddebab591a2d52ced51","type":"text","conversion_output":true,"text":"worsened). These dichotomous outcomes will be analyzed using logistic regression, controlling for the","text_display":" worsened). These dichotomous outcomes will be analyzed using logistic regression, controlling for the","confidence":1,"confidence_rate":1},{"cnt":[[146,2161],[1931,2161],[1931,2211],[146,2211]],"region":{"top_left_x":146,"top_left_y":2161,"width":1786,"height":50},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da23184eb79b47c68dd757e6c5e44d03","type":"text","conversion_output":true,"text":"design effects of stratification by center and by baseline urge IE group. To assess the impact of additional","text_display":" design effects of stratification by center and by baseline urge IE group. To assess the impact of additional","confidence":0.9990236759185791,"confidence_rate":0.9999913557807578},{"cnt":[[146,2209],[1888,2209],[1888,2254],[146,2254]],"region":{"top_left_x":146,"top_left_y":2208,"width":1743,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51d314d9070e4794bf4624816caada76","type":"text","conversion_output":true,"text":"treatment prior to 1 year, sensitivity analyses will be conducted in which women who request additional","text_display":" treatment prior to 1 year, sensitivity analyses will be conducted in which women who request additional","confidence":0.99853515625,"confidence_rate":0.9999867936215969},{"cnt":[[146,2252],[1072,2252],[1072,2297],[146,2297]],"region":{"top_left_x":146,"top_left_y":2251,"width":927,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e664fab46a74cd58f852bc588f5eeb0","type":"text","conversion_output":true,"text":"treatment will be assigned the less-favorable outcome.","text_display":" treatment will be assigned the less-favorable outcome.","confidence":1,"confidence_rate":1},{"cnt":[[271,2295],[683,2295],[683,2342],[271,2342]],"region":{"top_left_x":270,"top_left_y":2294,"width":414,"height":48},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f846e398d3aa46149589e68629579dbd","type":"section_header","conversion_output":false,"children_ids":["724c0f9a240e480a8e3e5d79dd460b20"],"text":"","text_display":""},{"cnt":[[271,2297],[681,2297],[681,2340],[271,2340]],"region":{"top_left_x":270,"top_left_y":2296,"width":412,"height":44},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"724c0f9a240e480a8e3e5d79dd460b20","type":"text","conversion_output":true,"parent_id":"f846e398d3aa46149589e68629579dbd","text":"OAB-SAT-q and OAB-q","text_display":"\n\n\\section*{OAB-SAT-q and OAB-q}","confidence":0.99560546875,"confidence_rate":0.9998165078540375},{"cnt":[[273,2342],[1977,2342],[1977,2383],[273,2383]],"region":{"top_left_x":272,"top_left_y":2341,"width":1705,"height":42},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b5904f09b294a4592f65cbf88d85fae","type":"text","conversion_output":true,"text":"For these scales and associated subscales, differences from baseline will be calculated for the OAB-","text_display":"\n\nFor these scales and associated subscales, differences from baseline will be calculated for the OAB","confidence":1,"confidence_rate":1},{"cnt":[[146,2385],[1931,2385],[1931,2430],[146,2430]],"region":{"top_left_x":146,"top_left_y":2384,"width":1786,"height":46},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76f71662b8cb4fc485b5ec632c456515","type":"text","conversion_output":true,"text":"q , and methods described for analysis of the primary outcome will be used to test for differences between","text_display":"q , and methods described for analysis of the primary outcome will be used to test for differences between","confidence":1,"confidence_rate":1},{"cnt":[[146,2428],[1953,2428],[1953,2473],[146,2473]],"region":{"top_left_x":146,"top_left_y":2427,"width":1807,"height":46},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfe89ff5dea3441c92249b8d34e29bd3","type":"text","conversion_output":true,"text":"treatment groups at 12 months. For the OAB-SAT-q, differences in post-treatment scores will be compared","text_display":" treatment groups at 12 months. For the OAB-SAT-q, differences in post-treatment scores will be compared","confidence":1,"confidence_rate":1},{"cnt":[[146,2471],[432,2471],[432,2516],[146,2516]],"region":{"top_left_x":146,"top_left_y":2470,"width":286,"height":46},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7fdd392695040ed972190d3d840e052","type":"text","conversion_output":true,"text":"between groups.","text_display":" between groups.","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":58,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0becd569f654f78b505e180dd638f6b","type":"page_info","conversion_output":false,"text":"42","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"175ff60c97794b96a14ab58b14434e43","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-43","page":43,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90a6d4eed1a244fb89d8fe3e11f26f98","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41999dad05324cecb34a648d06c93a25","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5343ead0608a4fabaa4de65ee3f5ac34","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,254],[146,254]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":40},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e62ed086a57140ae8996fc9d1ee95982","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[144,301],[956,301],[956,350],[144,350]],"region":{"top_left_x":143,"top_left_y":300,"width":814,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b72e2df73534470aaf36c9d7b9e7513d","type":"section_header","conversion_output":false,"children_ids":["88e2779e13d64a1d9bffd9c32b096c5e"],"text":"","text_display":""},{"cnt":[[146,305],[952,305],[952,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":806,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88e2779e13d64a1d9bffd9c32b096c5e","type":"text","conversion_output":true,"parent_id":"b72e2df73534470aaf36c9d7b9e7513d","text":"b. Differences in time to failure between groups","text_display":"\n\n\\section*{b. Differences in time to failure between groups}","confidence":0.99951171875,"confidence_rate":0.9999907849387211},{"cnt":[[271,348],[1904,348],[1904,391],[271,391]],"region":{"top_left_x":270,"top_left_y":348,"width":1634,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f59375f43b61488cb422cf15e762470e","type":"text","conversion_output":true,"text":"Although our primary outcome is at 12 months, the team was interested in whether perioperative","text_display":"\n\nAlthough our primary outcome is at 12 months, the team was interested in whether perioperative","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1846,391],[1846,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1700,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c297c8761f949819d0b0649522b2c5c","type":"text","conversion_output":true,"text":"BPTx may be associated with a delayed time to failure compared to Control. In other words, is BPTx","text_display":" BPTx may be associated with a delayed time to failure compared to Control. In other words, is BPTx","confidence":1,"confidence_rate":1},{"cnt":[[146,434],[1962,434],[1962,479],[146,479]],"region":{"top_left_x":146,"top_left_y":433,"width":1816,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"488465a7de2c4c5289ea1c32adda5dfc","type":"text","conversion_output":true,"text":"associated with a significant effect, but the effect is not sustained at the 12 month time point? For example,","text_display":" associated with a significant effect, but the effect is not sustained at the 12 month time point? For example,","confidence":1,"confidence_rate":1},{"cnt":[[146,477],[1949,477],[1949,522],[146,522]],"region":{"top_left_x":146,"top_left_y":476,"width":1803,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d59b2ebc2b440deb0b1aa8bd0f9e65a","type":"text","conversion_output":true,"text":"if BPTx could delay the need for anti-muscarinics for up to 9 months, this would be relevant information for","text_display":" if BPTx could delay the need for anti-muscarinics for up to 9 months, this would be relevant information for","confidence":0.982421875,"confidence_rate":0.9998471284538064},{"cnt":[[146,524],[1876,524],[1876,569],[146,569]],"region":{"top_left_x":146,"top_left_y":524,"width":1730,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed227e0fd19c454f9c9363be19672e3e","type":"text","conversion_output":true,"text":"counseling women and perhaps clinically recommending perioperative BPTx. As described previously,","text_display":" counseling women and perhaps clinically recommending perioperative BPTx. As described previously,","confidence":1,"confidence_rate":1},{"cnt":[[146,567],[1815,567],[1815,612],[146,612]],"region":{"top_left_x":146,"top_left_y":567,"width":1670,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6be12d315bfa46949263bb51e79f4ed4","type":"text","conversion_output":true,"text":"failure will be defined as initiation of any additional treatment for either SUI or UUI/OAB symptoms.","text_display":" failure will be defined as initiation of any additional treatment for either SUI or UUI/OAB symptoms.","confidence":0.99755859375,"confidence_rate":0.9999769399702094},{"cnt":[[271,610],[1880,610],[1880,655],[271,655]],"region":{"top_left_x":270,"top_left_y":610,"width":1610,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05292616d6a14dd9b527e670a15533f8","type":"text","conversion_output":true,"text":"A class of survival model which can account for interval censoring (outcomes measured at pre-","text_display":"\n\nA class of survival model which can account for interval censoring (outcomes measured at pre","confidence":1,"confidence_rate":1},{"cnt":[[146,653],[1777,653],[1777,698],[146,698]],"region":{"top_left_x":146,"top_left_y":653,"width":1631,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d47944d3f9444d4184f2da99b5c035a8","type":"text","conversion_output":true,"text":"planned time points as opposed to continuously over time) will be used to determine if combined","text_display":"planned time points as opposed to continuously over time) will be used to determine if combined","confidence":1,"confidence_rate":1},{"cnt":[[146,698],[1912,698],[1912,741],[146,741]],"region":{"top_left_x":146,"top_left_y":698,"width":1767,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c64149cb589d47c1a538e274a12faae3","type":"text","conversion_output":true,"text":"MUS+BPTx is associated with a decrease time to failure compared to MUS alone between \\(3-12\\) months.","text_display":" MUS+BPTx is associated with a decrease time to failure compared to MUS alone between \\(3-12\\) months.","confidence":0.99755859375,"confidence_rate":0.9999767203534344},{"cnt":[[146,743],[1938,743],[1938,786],[146,786]],"region":{"top_left_x":146,"top_left_y":743,"width":1792,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f4ac90d5f09431ca614636de65fad4b","type":"text","conversion_output":true,"text":"Depending on the distribution of the observed data, an accelerated failure time frailty model or a Bayesian","text_display":" Depending on the distribution of the observed data, an accelerated failure time frailty model or a Bayesian","confidence":1,"confidence_rate":1},{"cnt":[[146,786],[1962,786],[1962,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1816,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36ced6d24ad34f6cbd79df30cc7c2f5e","type":"text","conversion_output":true,"text":"survival model may be used. The model will be adjusted for the design effects of stratification by center and","text_display":" survival model may be used. The model will be adjusted for the design effects of stratification by center and","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[146,829],[597,829],[597,874],[146,874]],"region":{"top_left_x":146,"top_left_y":829,"width":452,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72b8e8de84954c87a57648ffa9fcb47d","type":"text","conversion_output":true,"text":"by baseline urge IE group.","text_display":" by baseline urge IE group.","confidence":1,"confidence_rate":1},{"cnt":[[142,915],[922,915],[922,960],[142,960]],"region":{"top_left_x":141,"top_left_y":915,"width":781,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"612b90d222e84eb8a14fa345adbf25bb","type":"section_header","conversion_output":false,"children_ids":["41d3195d2ea1493a8a882d491b29c33c"],"text":"","text_display":""},{"cnt":[[146,920],[917,920],[917,956],[146,956]],"region":{"top_left_x":146,"top_left_y":919,"width":772,"height":38},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41d3195d2ea1493a8a882d491b29c33c","type":"text","conversion_output":true,"parent_id":"612b90d222e84eb8a14fa345adbf25bb","text":"c. Predictors of treatment success and failure","text_display":"\n\n\\section*{c. Predictors of treatment success and failure}","confidence":1,"confidence_rate":1},{"cnt":[[271,962],[1921,962],[1921,1008],[271,1008]],"region":{"top_left_x":270,"top_left_y":962,"width":1651,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"769f21f63b0549a99dcf90d80aacd932","type":"text","conversion_output":true,"text":"Regression models will be created to identify predictors of change from baseline to 1 year for UDI","text_display":"\n\nRegression models will be created to identify predictors of change from baseline to 1 year for UDI","confidence":1,"confidence_rate":1},{"cnt":[[146,1005],[1962,1005],[1962,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1005,"width":1816,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d71300a39c149ba86eef431172a0286","type":"text","conversion_output":true,"text":"total score and stress and irritative subscale scores. Participants who request additional treatment prior to 1","text_display":" total score and stress and irritative subscale scores. Participants who request additional treatment prior to 1","confidence":0.9990234375,"confidence_rate":0.9999915040391533},{"cnt":[[146,1051],[1897,1051],[1897,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1050,"width":1752,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44bdb73a6aab4edfbe7ee512c1c9897c","type":"text","conversion_output":true,"text":"year will not be included in the predictive models. Potential predictors will include age, diary parameters","text_display":" year will not be included in the predictive models. Potential predictors will include age, diary parameters","confidence":1,"confidence_rate":1},{"cnt":[[146,1094],[1858,1094],[1858,1137],[146,1137]],"region":{"top_left_x":146,"top_left_y":1093,"width":1713,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9646e632b5284591ad44f1ba3c1f1cf9","type":"text","conversion_output":true,"text":"such as number of UUI episodes/3 days, functional bladder capacity, bother severity at baseline. The","text_display":" such as number of UUI episodes/3 days, functional bladder capacity, bother severity at baseline. The","confidence":1,"confidence_rate":1},{"cnt":[[146,1139],[1979,1139],[1979,1182],[146,1182]],"region":{"top_left_x":146,"top_left_y":1138,"width":1833,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdb4d904bcb34edf97dde61a7f544927","type":"text","conversion_output":true,"text":"relationship between potential predictors and outcomes will be explored in models that include one predictor","text_display":" relationship between potential predictors and outcomes will be explored in models that include one predictor","confidence":1,"confidence_rate":1},{"cnt":[[146,1182],[1923,1182],[1923,1227],[146,1227]],"region":{"top_left_x":146,"top_left_y":1181,"width":1777,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"649fce78b318472784a0e021d9324f63","type":"text","conversion_output":true,"text":"plus stratification factors (center and baseline urge IE group). Predictive models will be constructed using","text_display":" plus stratification factors (center and baseline urge IE group). Predictive models will be constructed using","confidence":1,"confidence_rate":1},{"cnt":[[146,1225],[1901,1225],[1901,1270],[146,1270]],"region":{"top_left_x":146,"top_left_y":1224,"width":1756,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"790c078e61874e87a6da7bafd18d3f88","type":"text","conversion_output":true,"text":"backward selection of predictors. The impact of collinearity between predictors will be assessed and the","text_display":" backward selection of predictors. The impact of collinearity between predictors will be assessed and the","confidence":1,"confidence_rate":1},{"cnt":[[146,1268],[737,1268],[737,1313],[146,1313]],"region":{"top_left_x":146,"top_left_y":1267,"width":591,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b79b8c870f6b4a5f9d01b9b4804f5e75","type":"text","conversion_output":true,"text":"final model modified as necessary.","text_display":" final model modified as necessary.","confidence":1,"confidence_rate":1},{"cnt":[[142,1354],[728,1354],[728,1403],[142,1403]],"region":{"top_left_x":141,"top_left_y":1353,"width":588,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0744bf44ae14a18b20bf6932c9946b5","type":"section_header","conversion_output":false,"children_ids":["de3c89d7d97d4585b271e394b64be79c"],"text":"","text_display":""},{"cnt":[[146,1358],[724,1358],[724,1403],[146,1403]],"region":{"top_left_x":146,"top_left_y":1357,"width":579,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de3c89d7d97d4585b271e394b64be79c","type":"text","conversion_output":true,"parent_id":"f0744bf44ae14a18b20bf6932c9946b5","text":"d. Quality of life/global impression","text_display":"\n\n\\section*{d. Quality of life/global impression}","confidence":1,"confidence_rate":1},{"cnt":[[271,1401],[1826,1401],[1826,1446],[271,1446]],"region":{"top_left_x":270,"top_left_y":1400,"width":1557,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcbd104dcde3473a86f511d4388bc918","type":"text","conversion_output":true,"text":"For these scales and associated subscales, differences from baseline will be calculated and","text_display":"\n\nFor these scales and associated subscales, differences from baseline will be calculated and","confidence":1,"confidence_rate":1},{"cnt":[[146,1446],[1811,1446],[1811,1489],[146,1489]],"region":{"top_left_x":146,"top_left_y":1445,"width":1666,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec67c17ac0f940f18aa0dbed20b39cf6","type":"text","conversion_output":true,"text":"methods described for analysis of the primary outcome will be used to test for differences between","text_display":" methods described for analysis of the primary outcome will be used to test for differences between","confidence":1,"confidence_rate":1},{"cnt":[[146,1489],[1059,1489],[1059,1534],[146,1534]],"region":{"top_left_x":146,"top_left_y":1488,"width":914,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"098913d506d34f5185dd20375892ce34","type":"text","conversion_output":true,"text":"treatment groups from baseline and 6 and 12 months.","text_display":" treatment groups from baseline and 6 and 12 months.","confidence":1,"confidence_rate":1},{"cnt":[[146,1577],[1824,1577],[1824,1622],[146,1622]],"region":{"top_left_x":146,"top_left_y":1576,"width":1679,"height":47},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f4d42c6cb7d41a080635f2711647eb8","type":"text","conversion_output":true,"text":"e. To describe safety and initiation of additional treatment for worsening OAB and/or persistent SUI","text_display":"\ne. To describe safety and initiation of additional treatment for worsening OAB and/or persistent SUI","confidence":1,"confidence_rate":1},{"cnt":[[271,1620],[1886,1620],[1886,1665],[271,1665]],"region":{"top_left_x":270,"top_left_y":1619,"width":1617,"height":47},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77ffadcd18324d63b0846e92cbc71be8","type":"text","conversion_output":true,"text":"We will describe rates of sling revision due to worsening OAB symptoms and rates of additional","text_display":"\n\nWe will describe rates of sling revision due to worsening OAB symptoms and rates of additional","confidence":1,"confidence_rate":1},{"cnt":[[146,1663],[324,1663],[324,1704],[146,1704]],"region":{"top_left_x":146,"top_left_y":1662,"width":179,"height":42},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1334aa8d55064500a483e599b3a28803","type":"text","conversion_output":true,"text":"treatment.","text_display":" treatment.","confidence":1,"confidence_rate":1},{"cnt":[[144,1749],[1708,1749],[1708,1798],[144,1798]],"region":{"top_left_x":143,"top_left_y":1748,"width":1566,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fed929445e024fde8fededc574d054b0","type":"text","conversion_output":true,"text":"f. To determine MIDs and clinically meaningful MUI definitions that predict clinical outcomes.","text_display":"\nf. To determine MIDs and clinically meaningful MUI definitions that predict clinical outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[316,1796],[1949,1796],[1949,1841],[316,1841]],"region":{"top_left_x":315,"top_left_y":1796,"width":1634,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"767f5dffc0224e4286b0978dc26647ab","type":"text","conversion_output":true,"text":"We will explore potential MIDs for UDI total score and stress and irritative subscores for this MUI","text_display":"\n\nWe will explore potential MIDs for UDI total score and stress and irritative subscores for this MUI","confidence":1,"confidence_rate":1},{"cnt":[[146,1839],[1893,1839],[1893,1884],[146,1884]],"region":{"top_left_x":146,"top_left_y":1839,"width":1747,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2cca304b4a264747b89a1c79850a32e1","type":"text","conversion_output":true,"text":"population. MIDs will be calculated using anchor- and distribution-based approaches. Potential anchors","text_display":" population. MIDs will be calculated using anchor- and distribution-based approaches. Potential anchors","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[146,1884],[1824,1884],[1824,1929],[146,1929]],"region":{"top_left_x":146,"top_left_y":1884,"width":1679,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bacce30cdd5940ddbb9eccc071da2178","type":"text","conversion_output":true,"text":"include global impression of change, incontinence episodes from the bladder diary, and request for","text_display":" include global impression of change, incontinence episodes from the bladder diary, and request for","confidence":1,"confidence_rate":1},{"cnt":[[146,1929],[501,1929],[501,1966],[146,1966]],"region":{"top_left_x":146,"top_left_y":1929,"width":355,"height":37},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8ba82a88f8c46fda164ab7b55f2ca56","type":"text","conversion_output":true,"text":"additional treatment.","text_display":" additional treatment.","confidence":1,"confidence_rate":1},{"cnt":[[271,1972],[1957,1972],[1957,2017],[271,2017]],"region":{"top_left_x":270,"top_left_y":1972,"width":1688,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dedb814ef2fc4c4095d32b428e102ae1","type":"text","conversion_output":true,"text":"We will attempt to create threshold definitions, based on baseline measures of the UDI, IIQ, OAB-q,","text_display":"\n\nWe will attempt to create threshold definitions, based on baseline measures of the UDI, IIQ, OAB-q,","confidence":1,"confidence_rate":1},{"cnt":[[146,2015],[1921,2015],[1921,2060],[146,2060]],"region":{"top_left_x":146,"top_left_y":2015,"width":1775,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a02422d91d6c4c18bd5bcad94d92351b","type":"text","conversion_output":true,"text":"UDE, and baseline bladder diary parameters in isolation and in combination, that are predictive of clinical","text_display":" UDE, and baseline bladder diary parameters in isolation and in combination, that are predictive of clinical","confidence":1,"confidence_rate":1},{"cnt":[[146,2058],[1938,2058],[1938,2103],[146,2103]],"region":{"top_left_x":146,"top_left_y":2058,"width":1792,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16521d82730d443d96dcfe880bd292c5","type":"text","conversion_output":true,"text":"success at 1 year. Definitions of success will be based on a change from baseline in total UDI score, UDI-","text_display":" success at 1 year. Definitions of success will be based on a change from baseline in total UDI score, UDI","confidence":1,"confidence_rate":1},{"cnt":[[146,2103],[1607,2103],[1607,2151],[146,2151]],"region":{"top_left_x":146,"top_left_y":2103,"width":1462,"height":48},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5af14f99070c4d71bca8ddbc618d1088","type":"text","conversion_output":true,"text":"irritative score or UDI-stress score at least as large as the MID for this MUI population.","text_display":"irritative score or UDI-stress score at least as large as the MID for this MUI population.","confidence":1,"confidence_rate":1},{"cnt":[[146,2191],[1962,2191],[1962,2237],[146,2237]],"region":{"top_left_x":146,"top_left_y":2191,"width":1816,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"995f3a80dfa040879d7b7614f4e791d6","type":"text","conversion_output":true,"text":"g. To compare pelvic floor muscle strength changes between women randomized to combined MUS+BPTx","text_display":"\ng. To compare pelvic floor muscle strength changes between women randomized to combined MUS+BPTx","confidence":0.98779296875,"confidence_rate":0.9998784019580803},{"cnt":[[146,2234],[1880,2234],[1880,2279],[146,2279]],"region":{"top_left_x":146,"top_left_y":2234,"width":1734,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9faf02400b1c4be7b71bceffce144ee9","type":"text","conversion_output":true,"text":"versus MUS alone, to estimate associations between pelvic floor muscle strength improvement and UI","text_display":" versus MUS alone, to estimate associations between pelvic floor muscle strength improvement and UI","confidence":0.99658203125,"confidence_rate":0.9999667595490823},{"cnt":[[146,2322],[146,2276],[1766,2278],[1766,2325]],"region":{"top_left_x":146,"top_left_y":2276,"width":1621,"height":49},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19b0a3f149cc412db2eb2035c5a5a927","type":"text","conversion_output":true,"text":"symptoms, and to identify predictors of unsuccessful pelvic floor muscle strengthening and urge","text_display":" symptoms, and to identify predictors of unsuccessful pelvic floor muscle strengthening and urge","confidence":1,"confidence_rate":1},{"cnt":[[146,2325],[1532,2325],[1532,2368],[146,2368]],"region":{"top_left_x":146,"top_left_y":2324,"width":1386,"height":44},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"317ef1ab2a4b4c9598391c6999ccdd13","type":"text","conversion_output":true,"text":"suppression and their effects on urinary outcomes in women randomized to BPTx","text_display":" suppression and their effects on urinary outcomes in women randomized to BPTx","confidence":1,"confidence_rate":1},{"cnt":[[271,2368],[1968,2368],[1968,2413],[271,2413]],"region":{"top_left_x":270,"top_left_y":2367,"width":1698,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7a47e6fe3b549d681d4a588de73d9eb","type":"text","conversion_output":true,"text":"As mentioned above, all women will undergo PFM strength measurements using the Peritron device","text_display":"\n\nAs mentioned above, all women will undergo PFM strength measurements using the Peritron device","confidence":1,"confidence_rate":1},{"cnt":[[146,2411],[1848,2411],[1848,2456],[146,2456]],"region":{"top_left_x":146,"top_left_y":2410,"width":1702,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a713d19dfc7d441fb415932a07e04951","type":"text","conversion_output":true,"text":"by masked coordinators at baseline, postoperative at 2 weeks, 8 weeks (end of intervention), and 12","text_display":" by masked coordinators at baseline, postoperative at 2 weeks, 8 weeks (end of intervention), and 12","confidence":1,"confidence_rate":1},{"cnt":[[146,2454],[1828,2454],[1828,2499],[146,2499]],"region":{"top_left_x":146,"top_left_y":2453,"width":1683,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6aba68283264d31a8ea8840b1729b2b","type":"text","conversion_output":true,"text":"months (primary endpoint). The difference in the maximum pelvic floor muscle contraction pressure","text_display":" months (primary endpoint). The difference in the maximum pelvic floor muscle contraction pressure","confidence":1,"confidence_rate":1},{"cnt":[[146,2499],[1931,2499],[1931,2546],[146,2546]],"region":{"top_left_x":146,"top_left_y":2498,"width":1786,"height":48},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46f151c502d84939a8f58fc9b7a79053","type":"text","conversion_output":true,"text":"(maximum amplitude) will be compared between the BPTx and the control groups. A table of comparative","text_display":" (maximum amplitude) will be compared between the BPTx and the control groups. A table of comparative","confidence":1,"confidence_rate":1},{"cnt":[[1036,2548],[1089,2548],[1089,2593],[1036,2593]],"region":{"top_left_x":1035,"top_left_y":2548,"width":55,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff21295b9d314677a6545595657201a8","type":"page_info","conversion_output":false,"text":"43","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"854e2b1e5da34fb59b362ebe7dc35719","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-44","page":44,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b06fa94c9f448709e36cc7d09343f1e","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d248e65bc58d449bb9b7bba9327eeddc","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[148,172],[307,172],[307,208],[148,208]],"region":{"top_left_x":148,"top_left_y":171,"width":160,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f24b67c65363489183d5baed17006c32","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,256],[146,256]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f4d65ffe3d54493b6d316688d5561d3","type":"section_header","conversion_output":false,"children_ids":["da53734585c04dd5b672d4f8f3f00e94"],"text":"","text_display":""},{"cnt":[[150,217],[354,217],[354,251],[150,251]],"region":{"top_left_x":150,"top_left_y":216,"width":205,"height":36},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da53734585c04dd5b672d4f8f3f00e94","type":"text","conversion_output":true,"parent_id":"6f4d65ffe3d54493b6d316688d5561d3","text":"Confidential","text_display":"\n\n\\section*{Confidential}","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1949,260],[1949,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1803,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a41ecef58804c2094f8d60627c8f64c","type":"text","conversion_output":true,"text":"studies using the Peritron device to measure PFM strength changes with PFM therapy is provided in Table","text_display":"\nstudies using the Peritron device to measure PFM strength changes with PFM therapy is provided in Table","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[150,305],[312,305],[312,342],[150,342]],"region":{"top_left_x":150,"top_left_y":305,"width":162,"height":37},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"461649afe36b41b2bccc4c59359dc134","type":"text","conversion_output":true,"text":"12 below.","text_display":" 12 below.","confidence":1,"confidence_rate":1},{"cnt":[[275,348],[1914,348],[1914,391],[275,391]],"region":{"top_left_x":275,"top_left_y":348,"width":1640,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da9aafc20cb740289e1fcdb236b186e5","type":"text","conversion_output":true,"text":"Based on the existing comparative studies using the Peritron, continent women have a maximum","text_display":"\n\nBased on the existing comparative studies using the Peritron, continent women have a maximum","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1940,391],[1940,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1795,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2578f0cd21ec4204a33c5a7c94e25233","type":"text","conversion_output":true,"text":"amplitude PFM contraction between \\(36-45 cm H 2 O\\). Incontinent women have significantly lower maximum","text_display":" amplitude PFM contraction between \\(36-45 cm H 2 O\\). Incontinent women have significantly lower maximum","confidence":0.9027011724640488,"confidence_rate":0.999086455858639},{"cnt":[[146,436],[1923,436],[1923,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1777,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"572cbcb2b47a444abeadfe0eb0acc88d","type":"text","conversion_output":true,"text":"contractions, ranging from 15.5 to 26.5 cm H 2 O , with most studies showing a maximum contraction of 25","text_display":" contractions, ranging from 15.5 to 26.5 cm H 2 O , with most studies showing a maximum contraction of 25","confidence":0.44640075468750345,"confidence_rate":0.9931302168955675},{"cnt":[[146,481],[1957,481],[1957,522],[146,522]],"region":{"top_left_x":146,"top_left_y":481,"width":1812,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1df4994d7a304de5b2cb18b3bd5c4aca","type":"text","conversion_output":true,"text":"cm H2O. In these studies, incontinent women can improve their maximum contraction pressure up to 34-41","text_display":" cm H2O. In these studies, incontinent women can improve their maximum contraction pressure up to 34-41","confidence":0.8181175505742431,"confidence_rate":0.9981599587366708},{"cnt":[[146,524],[1863,524],[1863,567],[146,567]],"region":{"top_left_x":146,"top_left_y":524,"width":1717,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9481864cee7c466a82eaa25cc7b802dc","type":"text","conversion_output":true,"text":"\\(cm H2O\\) with PFM training, which is comparable to continent women. In addition, these studies report","text_display":" \\(cm H2O\\) with PFM training, which is comparable to continent women. In addition, these studies report","confidence":0.40200270651098435,"confidence_rate":0.9914397133067728},{"cnt":[[146,567],[1899,567],[1899,610],[146,610]],"region":{"top_left_x":146,"top_left_y":567,"width":1754,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"257008e0424d4dd3a963e962e454baea","type":"text","conversion_output":true,"text":"women experience significant improvement in UI symptoms, although there is limited information on the","text_display":" women experience significant improvement in UI symptoms, although there is limited information on the","confidence":0.99853515625,"confidence_rate":0.9999861706835268},{"cnt":[[146,610],[1592,610],[1592,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1446,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"adfe7b3e23de472fbe557c76979f5136","type":"text","conversion_output":true,"text":"direct specific relationship between PFM strength changes and UI symptom changes.","text_display":" direct specific relationship between PFM strength changes and UI symptom changes.","confidence":1,"confidence_rate":1},{"cnt":[[271,655],[1949,655],[1949,698],[271,698]],"region":{"top_left_x":270,"top_left_y":655,"width":1679,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d9e0c9f3a8e456791824ca747eda20c","type":"text","conversion_output":true,"text":"Assuming that women in ESTEEM will have a mean baseline PFM maximum contraction amplitude","text_display":"\n\nAssuming that women in ESTEEM will have a mean baseline PFM maximum contraction amplitude","confidence":1,"confidence_rate":1},{"cnt":[[146,700],[1824,700],[1824,741],[146,741]],"region":{"top_left_x":146,"top_left_y":700,"width":1679,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f96ea6ca458f4de4a323c570064d9d6a","type":"text","conversion_output":true,"text":"of 25 cm H 2 O , and that women randomized to control will not demonstrate significant improvement","text_display":" of 25 cm H 2 O , and that women randomized to control will not demonstrate significant improvement","confidence":0.6715772004099563,"confidence_rate":0.9963541275059997},{"cnt":[[146,743],[1850,743],[1850,786],[146,786]],"region":{"top_left_x":146,"top_left_y":743,"width":1704,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85c92a8a1c534f56a40e34dae986c851","type":"text","conversion_output":true,"text":"postoperatively (no change from mean maximum amplitude of 25 cm H 2 O (SD 13), and that women","text_display":" postoperatively (no change from mean maximum amplitude of 25 cm H 2 O (SD 13), and that women","confidence":0.876584529876709,"confidence_rate":0.9987342427182908},{"cnt":[[146,786],[1919,786],[1919,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1773,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c01d061b5fcf4af6a96cf715f118ce85","type":"text","conversion_output":true,"text":"randomized to BPTx will demonstrate improvement to 35 (SD 13) to 40 (SD 16) \\(cm H2O\\) at 6-12 months,","text_display":" randomized to BPTx will demonstrate improvement to 35 (SD 13) to 40 (SD 16) \\(cm H2O\\) at 6-12 months,","confidence":0.704894472956706,"confidence_rate":0.9969636870275139},{"cnt":[[146,831],[1936,831],[1936,874],[146,874]],"region":{"top_left_x":146,"top_left_y":831,"width":1790,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a416f11c6574aaaab911799354be37f","type":"text","conversion_output":true,"text":"the power to detect a difference between the groups with the current ESTEEM sample size of 400 women","text_display":" the power to detect a difference between the groups with the current ESTEEM sample size of 400 women","confidence":1,"confidence_rate":1},{"cnt":[[146,874],[1916,874],[1916,917],[146,917]],"region":{"top_left_x":146,"top_left_y":874,"width":1771,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8252d2091994fd6b8d04253febe4fb1","type":"text","conversion_output":true,"text":"would be greater than 0.99 . Also, the difference from 25 (SD 13) that we could detect with \\(80 \\%\\) power is","text_display":" would be greater than 0.99 . Also, the difference from 25 (SD 13) that we could detect with \\(80 \\%\\) power is","confidence":0.9878287315368652,"confidence_rate":0.9998962261907406},{"cnt":[[146,920],[1946,920],[1946,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1801,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ca03fb8ec2b46059abe5643694fd506","type":"text","conversion_output":true,"text":"\\(3.66 cm H2O\\) between groups and with \\(90 \\%\\) power we could detect a difference as small as \\(4.23 cm H2O\\).","text_display":" \\(3.66 cm H2O\\) between groups and with \\(90 \\%\\) power we could detect a difference as small as \\(4.23 cm H2O\\).","confidence":0.45966598825975397,"confidence_rate":0.9932051622484878},{"cnt":[[271,962],[1841,962],[1841,1008],[271,1008]],"region":{"top_left_x":270,"top_left_y":962,"width":1572,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bafeb853dd2b4dd6893316b5fb6f4127","type":"text","conversion_output":true,"text":"For analyses, we will compare the mean change from baseline in PFM maximum contraction","text_display":"\n\nFor analyses, we will compare the mean change from baseline in PFM maximum contraction","confidence":1,"confidence_rate":1},{"cnt":[[146,1008],[1811,1008],[1811,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1007,"width":1666,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f1d58210079464aa4af9569ec0cc781","type":"text","conversion_output":true,"text":"strength between the BPTx and control groups at 8 weeks and at 12 months. General linear mixed","text_display":" strength between the BPTx and control groups at 8 weeks and at 12 months. General linear mixed","confidence":0.99853515625,"confidence_rate":0.9999860389766703},{"cnt":[[146,1053],[1921,1053],[1921,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1052,"width":1775,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3e37938302f439d9a1dfd2d2ee4b51a","type":"text","conversion_output":true,"text":"modeling will be used, controlling for stratification factors and time ( 8 weeks and 12 months). We will test","text_display":" modeling will be used, controlling for stratification factors and time ( 8 weeks and 12 months). We will test","confidence":1,"confidence_rate":1},{"cnt":[[146,1096],[1938,1096],[1938,1137],[146,1137]],"region":{"top_left_x":146,"top_left_y":1095,"width":1792,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10db6ed68575403280f6d2a53616fce9","type":"text","conversion_output":true,"text":"whether there is significant interaction between treatment group and time. Because additional treatment is","text_display":" whether there is significant interaction between treatment group and time. Because additional treatment is","confidence":1,"confidence_rate":1},{"cnt":[[146,1139],[1949,1139],[1949,1182],[146,1182]],"region":{"top_left_x":146,"top_left_y":1138,"width":1803,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c057bcb97234a0f87bbd7b885469b10","type":"text","conversion_output":true,"text":"not expected to impact this outcome, it will be ignored for the purpose of this analysis. We will estimate the","text_display":" not expected to impact this outcome, it will be ignored for the purpose of this analysis. We will estimate the","confidence":1,"confidence_rate":1},{"cnt":[[146,1182],[1841,1182],[1841,1227],[146,1227]],"region":{"top_left_x":146,"top_left_y":1181,"width":1696,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94a61e8512c94040a4144efd84d3be7c","type":"text","conversion_output":true,"text":"correlation between PFM strength and UI symptoms at baseline and at 12 months. Using regression","text_display":" correlation between PFM strength and UI symptoms at baseline and at 12 months. Using regression","confidence":1,"confidence_rate":1},{"cnt":[[146,1225],[1962,1225],[1962,1270],[146,1270]],"region":{"top_left_x":146,"top_left_y":1224,"width":1816,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b958e6e41474d4ba2ce2cce8792eab2","type":"text","conversion_output":true,"text":"models, we will also explore potential predictors of unsuccessful pelvic floor muscle strengthening and urge","text_display":" models, we will also explore potential predictors of unsuccessful pelvic floor muscle strengthening and urge","confidence":1,"confidence_rate":1},{"cnt":[[146,1268],[1794,1268],[1794,1313],[146,1313]],"region":{"top_left_x":146,"top_left_y":1267,"width":1648,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d13c80375c564e3a9299af80400609e1","type":"text","conversion_output":true,"text":"suppression and their effects on urinary outcomes. We will assess the effect of self-efficacy \\({ }^{114,115}\\),","text_display":" suppression and their effects on urinary outcomes. We will assess the effect of self-efficacy \\({ }^{114,115}\\),","confidence":0.9868740197271109,"confidence_rate":0.9998880326477712},{"cnt":[[146,1315],[1661,1315],[1661,1360],[146,1360]],"region":{"top_left_x":146,"top_left_y":1314,"width":1515,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6dcdb52fcfa5467ebea38afaeb505459","type":"text","conversion_output":true,"text":"adherence, and barriers to performing pelvic muscle contractions and behavioral therapy.","text_display":" adherence, and barriers to performing pelvic muscle contractions and behavioral therapy.","confidence":0.994631290435791,"confidence_rate":0.9999421180959227},{"cnt":[[146,1446],[1678,1446],[1678,1489],[146,1489]],"region":{"top_left_x":146,"top_left_y":1445,"width":1532,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f42894642c5947cca1d409e63f5fb7c6","type":"figure_label","conversion_output":false,"text":"Table 12. Comparative studies using Peritron measurement of pelvic floor muscle strength","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[114,1525],[2052,1525],[2052,2512],[114,2512]],"region":{"top_left_x":113,"top_left_y":1525,"width":1939,"height":987},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a70e6615e9f4849a376bafceef7efa3","type":"table","conversion_output":true,"children_ids":["0fa345d61a2649908a426fe578743fcd","01ba49ef262d4f389a0780642235a4b9","ace353cc9181444cb9e363897399f140","79629b27d3f24789a2464d4146ac3448","f604d0330bdb48bf9d7da9286fff0fb2","2378a76a198040e9ac5aa2d584657a71","586692e3a7e3447d91c3fb7dbd15c4a4","5d8fae4a81704599ab34292af552521b","a1b762a3ecc144ad9dd2068f14652cf4","2742a942e5f24387aba75abeb3bd77b5","c0c19d4719a94270ba738f54092a3183","7305b95f9ad84f60a79e12b2322f2ec4","e1669403d3cd460a8369dc938fb34f88","6ff72340be2b4854829155a164ed7bff","c1998526715445488c7808bed299bcb4","45c1e1d0c2ad490cb5b39860dafbe77a","9b6549a6c35f45318aa73026f2022619","b1bfa94a378b4fb5afcc3142c9d4543a","adc59f9adcb8438785fb0a462692ebc5","d2593de0bdcd47369f64f6d9416250cf","30f9e4052a9047bdb506b88d22627383","250b3d51a2e24ed0b5d0bc3a228fbff2","f357906c23eb44eb8bb45570ecefbaf4","783c0d22831a4896ad6efdd820661a9b","596fd00ed1fc448e984a5b6ba4a72c94","74a5a2d055d645dbaf30783fea8ebb96","3177006c02d949bf84d36dc3cfbc81ae","56618547e0b141e790f27b429867e54c","de4c4b3cbd7e45ce95a9fd2e8ab10c5e","d30cca057e4c408db59089d38fecd5ab","7b1591c660c94c0dbbf83ef1868a524a","7d8482739acd4c73a65dc36507da9a55","a6b9d86db71c40e1a750e251e5ae2cbf","8ed0098ca3d348ff92a6c506132c41a1","1d06cebb436e46a3ad136af97e775a1d","916da5b9b9ae47e9b0769fc178130898","c1f29b75a3574df297428e7e9053b213"],"selected_labels":["f42894642c5947cca1d409e63f5fb7c6"],"text":"\\begin{tabular}{|l|l|l|l|l|l|l|}\n\\hline Author & Pop & Study details & Baseline PFM strength (SD)* & Posttreatment PFM strength (SD) & P-value & Notes \\\\\n\\hline Rett \\(2007^{116}\\) & SUI & \\(N =26\\) Single cohort PFME with sEMG biofeedback & Max amp= 24.5 (16) & After 12 sessions: 40.0 (17) & <. 0001 & No info on \"subjective improvement\" and PFM strength Overall cohort: Obj cure = 61.5\\% Subj cure = 23\\% Subj \"almost cure\"=65.4\\% \\\\\n\\hline Gameiro \\(2010^{117}\\) & Any UI & \\(N =103\\) RCT G1 =vag cones G2 =APFMT & Max amp: G1=24.4 (12.5) G2=20.0 (12.9) & \\begin{tabular}{l}\n6 mos : G1=40.8 (15.73) G2=35.16 (11.05) \\\\\n12 mos : G1=34.98 (13.2) G2=34.12 (9.84)\n\\end{tabular} & P<. 05 for both & \\begin{tabular}{l}\n*No specific correlation btwn subjective \"cure\" and PFM strength; however: \\\\\na. Reduction of pads better for G1 \\\\\nb. \\# micturitions, nocturia, UI episodes, urgency, pad test ND btwn grps\n\\end{tabular} \\\\\n\\hline Amaro \\(2005^{118}\\) & SUI & \\(N =101\\) Comparative cohort G1 = SUI & Max amp: G1=26.1 (1.15) G2=38.4 (1.33) & & \\(P <.001\\) for all 3 baseline & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 12. Comparative studies using Peritron measurement of pelvic floor muscle strength}\n\\begin{tabular}{|l|l|l|l|l|l|l|}\n\\hline Author & Pop & Study details & Baseline PFM strength (SD)* & Posttreatment PFM strength (SD) & P-value & Notes \\\\\n\\hline Rett \\(2007^{116}\\) & SUI & \\(N =26\\) Single cohort PFME with sEMG biofeedback & Max amp= 24.5 (16) & After 12 sessions: 40.0 (17) & <. 0001 & No info on \"subjective improvement\" and PFM strength Overall cohort: Obj cure = 61.5\\% Subj cure = 23\\% Subj \"almost cure\"=65.4\\% \\\\\n\\hline Gameiro \\(2010^{117}\\) & Any UI & \\(N =103\\) RCT G1 =vag cones G2 =APFMT & Max amp: G1=24.4 (12.5) G2=20.0 (12.9) & \\begin{tabular}{l}\n6 mos : G1=40.8 (15.73) G2=35.16 (11.05) \\\\\n12 mos : G1=34.98 (13.2) G2=34.12 (9.84)\n\\end{tabular} & P<. 05 for both & \\begin{tabular}{l}\n*No specific correlation btwn subjective \"cure\" and PFM strength; however: \\\\\na. Reduction of pads better for G1 \\\\\nb. \\# micturitions, nocturia, UI episodes, urgency, pad test ND btwn grps\n\\end{tabular} \\\\\n\\hline Amaro \\(2005^{118}\\) & SUI & \\(N =101\\) Comparative cohort G1 = SUI & Max amp: G1=26.1 (1.15) G2=38.4 (1.33) & & \\(P <.001\\) for all 3 baseline & 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When estimating QALYs, we will also adjust for subjects'","text_display":" found to differ significantly between the groups. When estimating QALYs, we will also adjust for subjects'","confidence":1,"confidence_rate":1},{"cnt":[[146,2013],[1852,2013],[1852,2056],[146,2056]],"region":{"top_left_x":146,"top_left_y":2013,"width":1706,"height":44},"line":107,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5e9689f7ca145e79846305ecb87fe42","type":"text","conversion_output":true,"text":"baseline utility scores to account for potential imbalance in baseline utility between the two treatment","text_display":" baseline utility scores to account for potential imbalance in baseline utility between the two treatment","confidence":1,"confidence_rate":1},{"cnt":[[146,2054],[322,2054],[322,2101],[146,2101]],"region":{"top_left_x":146,"top_left_y":2053,"width":177,"height":49},"line":108,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45fbe3981ee048dfbc2e437fa135336b","type":"text","conversion_output":true,"text":"groups. \\({ }^{122}\\)","text_display":" groups. \\({ }^{122}\\)","confidence":0.99755859375,"confidence_rate":0.9998888974749892},{"cnt":[[271,2099],[1974,2099],[1974,2144],[271,2144]],"region":{"top_left_x":270,"top_left_y":2099,"width":1705,"height":46},"line":109,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aaa6950122c8426e93e138acd64fbfe6","type":"text","conversion_output":true,"text":"We will calculate the incremental cost-effectiveness ratio (ICER), which is the differential mean costs","text_display":"\n\nWe will calculate the incremental cost-effectiveness ratio (ICER), which is the differential mean costs","confidence":1,"confidence_rate":1},{"cnt":[[146,2144],[1944,2144],[1944,2189],[146,2189]],"region":{"top_left_x":146,"top_left_y":2144,"width":1799,"height":46},"line":110,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a871a1b3cf2e4e5381eb39f8501d3abc","type":"text","conversion_output":true,"text":"divided by the differential mean QALYs between the two groups, to assess the additional costs associated","text_display":" divided by the differential mean QALYs between the two groups, to assess the additional costs associated","confidence":1,"confidence_rate":1},{"cnt":[[144,2187],[1846,2187],[1846,2232],[144,2232]],"region":{"top_left_x":143,"top_left_y":2187,"width":1703,"height":46},"line":111,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5eba6b3e435474d8418b0a6fbafe105","type":"text","conversion_output":true,"text":"with each additional QALY gained. Our base case analysis will be conducted based on subjects with","text_display":" with each additional QALY gained. Our base case analysis will be conducted based on subjects with","confidence":1,"confidence_rate":1},{"cnt":[[146,2230],[1888,2230],[1888,2275],[146,2275]],"region":{"top_left_x":146,"top_left_y":2230,"width":1743,"height":46},"line":112,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a5ed4ece73f41d19cd48d2c0d047622","type":"text","conversion_output":true,"text":"complete data. Sensitivity analysis will be conducted to include subjects with incomplete data using the","text_display":" complete data. Sensitivity analysis will be conducted to include subjects with incomplete data using the","confidence":1,"confidence_rate":1},{"cnt":[[146,2275],[1953,2275],[1953,2320],[146,2320]],"region":{"top_left_x":146,"top_left_y":2275,"width":1807,"height":46},"line":113,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc52626a2a67427b925db55808173295","type":"text","conversion_output":true,"text":"multiple imputation method. Non-parametric bootstrapping resampling technique will be used to derive the","text_display":" multiple imputation method. Non-parametric bootstrapping resampling technique will be used to derive the","confidence":1,"confidence_rate":1},{"cnt":[[146,2316],[1929,2316],[1929,2365],[146,2365]],"region":{"top_left_x":146,"top_left_y":2316,"width":1784,"height":50},"line":114,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d34cea05376c4996b106882bdf6ef675","type":"text","conversion_output":true,"text":"\\(95 \\%\\) confidence interval for the ICER. \\({ }^{118, ~}{ }^{123}\\) In addition, cost-effectiveness acceptability curve (CEAC) will","text_display":" \\(95 \\%\\) confidence interval for the ICER. \\({ }^{118, ~}{ }^{123}\\) In addition, cost-effectiveness acceptability curve (CEAC) will","confidence":0.6346459239721298,"confidence_rate":0.9965351155784656},{"cnt":[[146,2363],[1957,2363],[1957,2408],[146,2408]],"region":{"top_left_x":146,"top_left_y":2363,"width":1812,"height":46},"line":115,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b1e0d3efc424b88a24a645ef53f7125","type":"text","conversion_output":true,"text":"be generated to illustrate the likelihood that one treatment is more cost-effective than the other with various","text_display":" be generated to illustrate the likelihood that one treatment is more cost-effective than the other with various","confidence":1,"confidence_rate":1},{"cnt":[[146,2408],[690,2408],[690,2451],[146,2451]],"region":{"top_left_x":146,"top_left_y":2408,"width":544,"height":44},"line":116,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3b9fcaec7d046b0a52c1691a2645ac6","type":"text","conversion_output":true,"text":"ceiling cost-effectiveness ratios.","text_display":" ceiling cost-effectiveness ratios.","confidence":1,"confidence_rate":1},{"cnt":[[271,2449],[1923,2449],[1923,2499],[271,2499]],"region":{"top_left_x":270,"top_left_y":2449,"width":1653,"height":50},"line":117,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"922e2def6b114c45ae0f5a21a286fc5f","type":"text","conversion_output":true,"text":"In the case that a statistically significant difference in changes in utilities (as measured by EQ-5D)","text_display":"\n\nIn the case that a statistically significant difference in changes in utilities (as measured by EQ-5D)","confidence":1,"confidence_rate":1},{"cnt":[[146,2496],[1949,2496],[1949,2542],[146,2542]],"region":{"top_left_x":146,"top_left_y":2496,"width":1803,"height":46},"line":118,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7fef8c7cdad499fb1d7f11f91ddc514","type":"text","conversion_output":true,"text":"between the treatment groups is not detected, we plan to conduct supplemental analyses using alternative","text_display":" between the treatment groups is not detected, we plan to conduct supplemental analyses using alternative","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[1036,2548],[1089,2548],[1089,2593],[1036,2593]],"region":{"top_left_x":1035,"top_left_y":2548,"width":55,"height":46},"line":119,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f51b5a139244bc1b63094152a45af43","type":"page_info","conversion_output":false,"text":"45","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":120,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fceb45989b24784bc1494d86fb1072b","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-46","page":46,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0defe7acab145f49ddf2f473137bd55","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"501de857b1e541f5acc761a44cdbad32","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"178766c98e72451aa8279d534b15c997","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c0ea1688a7a4a5c929ac292d529a2ae","type":"text","conversion_output":true,"text":"Confidential","text_display":"\n\nConfidential","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1884,260],[1884,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1739,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43839eba1e90479aa1c8d83e45fb9a9f","type":"text","conversion_output":true,"text":"outcome measures, such as incremental cost per treatment success, incremental cost per HRQOL, or","text_display":" outcome measures, such as incremental cost per treatment success, incremental cost per HRQOL, or","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[707,305],[707,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":561,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7374a4bfd5141c7b1c9a01abdd473b6","type":"text","conversion_output":true,"text":"incremental cost per satisfaction.","text_display":" incremental cost per satisfaction.","confidence":1,"confidence_rate":1},{"cnt":[[271,348],[1966,348],[1966,391],[271,391]],"region":{"top_left_x":270,"top_left_y":348,"width":1696,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbec05da53444111b17f0409b4d3f909","type":"text","conversion_output":true,"text":"The cost-effectiveness evaluations will be conducted as within-trial comparisons. A decision analytic","text_display":"\n\nThe cost-effectiveness evaluations will be conducted as within-trial comparisons. A decision analytic","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1938,391],[1938,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1792,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"210de452b5be47e78bbe613674b000bc","type":"text","conversion_output":true,"text":"model will also be developed from trial data to evaluate the trajectory of the cost-effectiveness ratio over a","text_display":" model will also be developed from trial data to evaluate the trajectory of the cost-effectiveness ratio over a","confidence":1,"confidence_rate":1},{"cnt":[[146,436],[1867,436],[1867,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1721,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e02fca88f68485d8602b850fd12996a","type":"text","conversion_output":true,"text":"lifetime; assuming an average life expectancy, given the average age of participants at the time of the","text_display":" lifetime; assuming an average life expectancy, given the average age of participants at the time of the","confidence":1,"confidence_rate":1},{"cnt":[[146,481],[359,481],[359,518],[146,518]],"region":{"top_left_x":146,"top_left_y":481,"width":213,"height":37},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df7811aaf2a94b1fa27e7016831f1bbe","type":"text","conversion_output":true,"text":"intervention.","text_display":" intervention.","confidence":1,"confidence_rate":1},{"cnt":[[142,606],[621,606],[621,655],[142,655]],"region":{"top_left_x":141,"top_left_y":605,"width":480,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54c40e7102504272a488a538893efd26","type":"section_header","conversion_output":false,"children_ids":["0239b2428c2b4e3a9bbd766256e129cf"],"text":"","text_display":""},{"cnt":[[146,610],[617,610],[617,651],[146,651]],"region":{"top_left_x":146,"top_left_y":610,"width":471,"height":41},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0239b2428c2b4e3a9bbd766256e129cf","type":"text","conversion_output":true,"parent_id":"54c40e7102504272a488a538893efd26","text":"6.3. Interim data monitoring","text_display":"\n\n\\subsection*{6.3. Interim data monitoring}","confidence":1,"confidence_rate":1},{"cnt":[[271,662],[1846,662],[1846,707],[271,707]],"region":{"top_left_x":270,"top_left_y":661,"width":1576,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b94879d9a4704dd08075460912448592","type":"text","conversion_output":true,"text":"Safety outcomes will be assessed at each DSMB meeting. This will include the need for sling","text_display":"\n\nSafety outcomes will be assessed at each DSMB meeting. This will include the need for sling","confidence":1,"confidence_rate":1},{"cnt":[[146,709],[1833,709],[1833,750],[146,750]],"region":{"top_left_x":146,"top_left_y":708,"width":1687,"height":42},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3c738dc8b9b46e89f72dbe52b73e6f1","type":"text","conversion_output":true,"text":"revision due to worsening OAB symptoms. Rates of sling revision and other safety outcomes will be","text_display":" revision due to worsening OAB symptoms. Rates of sling revision and other safety outcomes will be","confidence":0.998046875,"confidence_rate":0.9999808331754918},{"cnt":[[146,752],[1886,752],[1886,793],[146,793]],"region":{"top_left_x":146,"top_left_y":751,"width":1741,"height":42},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa5debb757b64211af75856400deb00f","type":"text","conversion_output":true,"text":"compared between treatment groups using Fisher's exact tests and provided to the DSMB. There is no","text_display":" compared between treatment groups using Fisher's exact tests and provided to the DSMB. There is no","confidence":1,"confidence_rate":1},{"cnt":[[146,795],[1974,795],[1974,838],[146,838]],"region":{"top_left_x":146,"top_left_y":794,"width":1829,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf9e108f07764ccea0901ef826e4f684","type":"text","conversion_output":true,"text":"established guidance regarding what sling revision rate is \"appropriate\" for worsening OAB symptoms in this","text_display":" established guidance regarding what sling revision rate is \"appropriate\" for worsening OAB symptoms in this","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[146,838],[1141,838],[1141,883],[146,883]],"region":{"top_left_x":146,"top_left_y":837,"width":995,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47debbbd83b74fde88e65dccb57ed130","type":"text","conversion_output":true,"text":"population: this is one of the exploratory aims of this study.","text_display":" population: this is one of the exploratory aims of this study.","confidence":1,"confidence_rate":1},{"cnt":[[271,883],[1938,883],[1938,926],[271,926]],"region":{"top_left_x":270,"top_left_y":883,"width":1668,"height":43},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d932d5758c4841e692e73d81eb14b26f","type":"text","conversion_output":true,"text":"Since we expect to enroll ESTEEM within 2 years, and since the primary outcome is attained at 12","text_display":"\n\nSince we expect to enroll ESTEEM within 2 years, and since the primary outcome is attained at 12","confidence":0.9941432476043701,"confidence_rate":0.9999429727869803},{"cnt":[[146,928],[1972,928],[1972,969],[146,969]],"region":{"top_left_x":146,"top_left_y":928,"width":1827,"height":41},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0b56cba71424a1ab381d9b1bc8633f3","type":"text","conversion_output":true,"text":"months following surgery, we propose that no interim analyses of outcomes will be performed. Thus, reports","text_display":" months following surgery, we propose that no interim analyses of outcomes will be performed. Thus, reports","confidence":0.9990236759185791,"confidence_rate":0.9999912000297451},{"cnt":[[146,971],[1970,971],[1970,1014],[146,1014]],"region":{"top_left_x":146,"top_left_y":971,"width":1825,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19c6053253a846c2ad60b83b6bb0df70","type":"text","conversion_output":true,"text":"to the DSMB will not include outcome data until primary outcomes have been attained for all participants. At","text_display":" to the DSMB will not include outcome data until primary outcomes have been attained for all participants. At","confidence":1,"confidence_rate":1},{"cnt":[[146,1014],[1955,1014],[1955,1059],[146,1059]],"region":{"top_left_x":146,"top_left_y":1014,"width":1810,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edb0ba0489fe4cb499018a8414ae672a","type":"text","conversion_output":true,"text":"each meeting, the DSMB will be presented with information about enrollment and outcome data attainment","text_display":" each meeting, the DSMB will be presented with information about enrollment and outcome data attainment","confidence":1,"confidence_rate":1},{"cnt":[[146,1057],[1972,1057],[1972,1102],[146,1102]],"region":{"top_left_x":146,"top_left_y":1057,"width":1827,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a860e17c2a4745da95bda2fa6e15c82e","type":"text","conversion_output":true,"text":"(for example, the percent of expected clinic visits that have been completed) to allow them to determine that","text_display":" (for example, the percent of expected clinic visits that have been completed) to allow them to determine that","confidence":1,"confidence_rate":1},{"cnt":[[146,1104],[844,1104],[844,1145],[146,1145]],"region":{"top_left_x":146,"top_left_y":1104,"width":699,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a21af621a3ef47d5bf053352fb643e6a","type":"text","conversion_output":true,"text":"the study is making reasonable progress.","text_display":" the study is making reasonable progress.","confidence":1,"confidence_rate":1},{"cnt":[[142,1229],[638,1229],[638,1278],[142,1278]],"region":{"top_left_x":141,"top_left_y":1228,"width":498,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"383d09d2a30c437fb8b5695359356824","type":"section_header","conversion_output":false,"children_ids":["6050640116a94a9185593addff02b3eb"],"text":"","text_display":""},{"cnt":[[146,1233],[634,1233],[634,1274],[146,1274]],"region":{"top_left_x":146,"top_left_y":1233,"width":488,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6050640116a94a9185593addff02b3eb","type":"text","conversion_output":true,"parent_id":"383d09d2a30c437fb8b5695359356824","text":"7. Ethical Concerns/Safety","text_display":"\n\n\\section*{7. Ethical Concerns/Safety}","confidence":1,"confidence_rate":1},{"cnt":[[144,1315],[518,1315],[518,1364],[144,1364]],"region":{"top_left_x":143,"top_left_y":1314,"width":375,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"900c1bf1d0074fb7b561f43f14dcaa1f","type":"section_header","conversion_output":false,"children_ids":["6b928901f33441bfae59b9299cd13ad4"],"text":"","text_display":""},{"cnt":[[146,1319],[518,1319],[518,1360],[146,1360]],"region":{"top_left_x":146,"top_left_y":1319,"width":372,"height":41},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b928901f33441bfae59b9299cd13ad4","type":"text","conversion_output":true,"parent_id":"900c1bf1d0074fb7b561f43f14dcaa1f","text":"7.1. Ethical Concerns","text_display":"\n\n\\subsection*{7.1. Ethical Concerns}","confidence":1,"confidence_rate":1},{"cnt":[[146,1416],[1970,1416],[1970,1459],[146,1459]],"region":{"top_left_x":146,"top_left_y":1415,"width":1825,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3e870170a424407ac8e936dc8f2b0af","type":"text","conversion_output":true,"text":"As discussed in the background section, current clinical practice varies with respect to treatment of MUI and","text_display":"\n\nAs discussed in the background section, current clinical practice varies with respect to treatment of MUI and","confidence":1,"confidence_rate":1},{"cnt":[[146,1461],[1901,1461],[1901,1502],[146,1502]],"region":{"top_left_x":146,"top_left_y":1460,"width":1756,"height":42},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09874e27c0444f88bf435e3479a78b01","type":"text","conversion_output":true,"text":"likely reflects training and experiential bias. Although treatment with behavioral modifications and Kegel","text_display":" likely reflects training and experiential bias. Although treatment with behavioral modifications and Kegel","confidence":1,"confidence_rate":1},{"cnt":[[146,1504],[1886,1504],[1886,1547],[146,1547]],"region":{"top_left_x":146,"top_left_y":1503,"width":1741,"height":44},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b391d38ab8ef4446ac5dda4dd3697204","type":"text","conversion_output":true,"text":"exercises have been described as effective first line treatments for mild stress, urge, and mixed urinary","text_display":" exercises have been described as effective first line treatments for mild stress, urge, and mixed urinary","confidence":1,"confidence_rate":1},{"cnt":[[146,1547],[1966,1547],[1966,1592],[146,1592]],"region":{"top_left_x":146,"top_left_y":1546,"width":1820,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f31ce7962afa4a7fa6a211e504b93a9e","type":"text","conversion_output":true,"text":"incontinence, many patients go on to request further therapy for their condition. For moderate symptoms of","text_display":" incontinence, many patients go on to request further therapy for their condition. For moderate symptoms of","confidence":0.99658203125,"confidence_rate":0.9999691552203086},{"cnt":[[146,1592],[1863,1592],[1863,1635],[146,1635]],"region":{"top_left_x":146,"top_left_y":1591,"width":1717,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b36e124a57646958b601e33eb5aa17c","type":"text","conversion_output":true,"text":"SUI or UUI additional therapeutic options are generally offered based on treatment paradigms geared","text_display":" SUI or UUI additional therapeutic options are generally offered based on treatment paradigms geared","confidence":1,"confidence_rate":1},{"cnt":[[146,1637],[1916,1637],[1916,1678],[146,1678]],"region":{"top_left_x":146,"top_left_y":1637,"width":1771,"height":41},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5509396797d42debe84d1c9bca8c2b1","type":"text","conversion_output":true,"text":"toward each of these conditions. When patients have MUI, clinicians must decide which component (the","text_display":" toward each of these conditions. When patients have MUI, clinicians must decide which component (the","confidence":1,"confidence_rate":1},{"cnt":[[146,1680],[1867,1680],[1867,1723],[146,1723]],"region":{"top_left_x":146,"top_left_y":1680,"width":1721,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e182beca79ba4551b4a702a2b6cf5e7b","type":"text","conversion_output":true,"text":"SUI or the UUI) should be addressed first. There is very little evidence to support a defined treatment","text_display":" SUI or the UUI) should be addressed first. There is very little evidence to support a defined treatment","confidence":1,"confidence_rate":1},{"cnt":[[146,1723],[1974,1723],[1974,1766],[146,1766]],"region":{"top_left_x":146,"top_left_y":1723,"width":1829,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e30ce7761ed4f0ca4ad91bf2e40a149","type":"text","conversion_output":true,"text":"strategy in this patient population and most recommendations are based on expert opinion. The only way to","text_display":" strategy in this patient population and most recommendations are based on expert opinion. The only way to","confidence":1,"confidence_rate":1},{"cnt":[[146,1766],[1906,1766],[1906,1811],[146,1811]],"region":{"top_left_x":146,"top_left_y":1766,"width":1760,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99c897d1f23a4453ba9e1eddacdf987e","type":"text","conversion_output":true,"text":"test the superiority of one approach over another is in the setting of a randomized clinical trial. We have","text_display":" test the superiority of one approach over another is in the setting of a randomized clinical trial. We have","confidence":0.9990234375,"confidence_rate":0.999991276469766},{"cnt":[[146,1811],[1867,1811],[1867,1854],[146,1854]],"region":{"top_left_x":146,"top_left_y":1811,"width":1721,"height":44},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"042a294104c74a0fb99dec6607e73b76","type":"text","conversion_output":true,"text":"carefully designed this trial to balance the risks and benefits to subjects. All patients in this study have","text_display":" carefully designed this trial to balance the risks and benefits to subjects. All patients in this study have","confidence":1,"confidence_rate":1},{"cnt":[[146,1856],[1867,1856],[1867,1897],[146,1897]],"region":{"top_left_x":146,"top_left_y":1856,"width":1721,"height":42},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f801ee4bc804afe85333052e4689dac","type":"text","conversion_output":true,"text":"elected to undergo surgery for SUI. Therefore, they will have already been offered more conservative","text_display":" elected to undergo surgery for SUI. Therefore, they will have already been offered more conservative","confidence":1,"confidence_rate":1},{"cnt":[[146,1899],[1953,1899],[1953,1944],[146,1944]],"region":{"top_left_x":146,"top_left_y":1899,"width":1807,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95ef53335a124d23b2a3d99279db9409","type":"text","conversion_output":true,"text":"therapies. We will be assured that women will have either previously tried behavioral or pelvic floor therapy","text_display":" therapies. We will be assured that women will have either previously tried behavioral or pelvic floor therapy","confidence":1,"confidence_rate":1},{"cnt":[[146,1942],[1949,1942],[1949,1985],[146,1985]],"region":{"top_left_x":146,"top_left_y":1942,"width":1803,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c70d43e156f94506943062b8956d66ae","type":"text","conversion_output":true,"text":"or at least have been offered this treatment because it is an inclusion criteria. In addition all patients will be","text_display":" or at least have been offered this treatment because it is an inclusion criteria. In addition all patients will be","confidence":1,"confidence_rate":1},{"cnt":[[146,1987],[1936,1987],[1936,2030],[146,2030]],"region":{"top_left_x":146,"top_left_y":1987,"width":1790,"height":44},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0763d8b437b4f5db09085307c6252b0","type":"text","conversion_output":true,"text":"treated with a midurethral sling and half the patients will be randomized to perioperative supervised BPTx.","text_display":" treated with a midurethral sling and half the patients will be randomized to perioperative supervised BPTx.","confidence":1,"confidence_rate":1},{"cnt":[[146,2032],[1940,2032],[1940,2073],[146,2073]],"region":{"top_left_x":146,"top_left_y":2032,"width":1795,"height":42},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1d618e7f82c455eafd3edc0a124b98c","type":"text","conversion_output":true,"text":"The potential benefits of the BPTx intervention are improvement of MUI symptoms while the risks are very","text_display":" The potential benefits of the BPTx intervention are improvement of MUI symptoms while the risks are very","confidence":1,"confidence_rate":1},{"cnt":[[146,2075],[1923,2075],[1923,2112],[146,2112]],"region":{"top_left_x":146,"top_left_y":2075,"width":1777,"height":37},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e0482ca028f4853a4ea58849cf09c68","type":"text","conversion_output":true,"text":"small. The benefits of BPTx in SUI and UUI alone and MUI have been documented as has the benefit of","text_display":" small. The benefits of BPTx in SUI and UUI alone and MUI have been documented as has the benefit of","confidence":1,"confidence_rate":1},{"cnt":[[146,2118],[1846,2118],[1846,2161],[146,2161]],"region":{"top_left_x":146,"top_left_y":2118,"width":1700,"height":44},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa800d0698c0495d9bddf5c328c8d710","type":"text","conversion_output":true,"text":"MUS for patients with SUI. Several studies have also documented an improvement in OAB and MUI","text_display":" MUS for patients with SUI. Several studies have also documented an improvement in OAB and MUI","confidence":1,"confidence_rate":1},{"cnt":[[146,2161],[1914,2161],[1914,2206],[146,2206]],"region":{"top_left_x":146,"top_left_y":2161,"width":1769,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66ced6d879b74344b9bda7ff2dba46fa","type":"text","conversion_output":true,"text":"symptoms following sling. The added benefit of a combined approach of sling plus BPTx in patients with","text_display":" symptoms following sling. The added benefit of a combined approach of sling plus BPTx in patients with","confidence":1,"confidence_rate":1},{"cnt":[[146,2204],[1974,2204],[1974,2249],[146,2249]],"region":{"top_left_x":146,"top_left_y":2204,"width":1829,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcf08dd77ce744618c22e4dd33333c5b","type":"text","conversion_output":true,"text":"MUI has not been defined and is the subject of this RCT. Any subject can request additional treatment after","text_display":" MUI has not been defined and is the subject of this RCT. Any subject can request additional treatment after","confidence":1,"confidence_rate":1},{"cnt":[[146,2252],[556,2252],[556,2292],[146,2292]],"region":{"top_left_x":146,"top_left_y":2251,"width":411,"height":42},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28af3640e86140d3a665dcada8c88491","type":"text","conversion_output":true,"text":"3 months postoperative.","text_display":" 3 months postoperative.","confidence":1,"confidence_rate":1},{"cnt":[[142,2376],[535,2376],[535,2426],[142,2426]],"region":{"top_left_x":141,"top_left_y":2376,"width":394,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fa02561b6b442d5a9829bd27e70a708","type":"section_header","conversion_output":false,"children_ids":["a149e63e6c9e4ca9b88ad9c4ce0ea2c5"],"text":"","text_display":""},{"cnt":[[146,2380],[531,2380],[531,2421],[146,2421]],"region":{"top_left_x":146,"top_left_y":2380,"width":385,"height":42},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a149e63e6c9e4ca9b88ad9c4ce0ea2c5","type":"text","conversion_output":true,"parent_id":"3fa02561b6b442d5a9829bd27e70a708","text":"7.2. Informed Consent","text_display":"\n\n\\subsection*{7.2. Informed Consent}","confidence":0.99462890625,"confidence_rate":0.9997928841463507},{"cnt":[[146,2436],[1850,2436],[1850,2477],[146,2477]],"region":{"top_left_x":146,"top_left_y":2436,"width":1704,"height":42},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd4e24fa3c554d389181f7be04e13099","type":"text","conversion_output":true,"text":"Subjects will be clinically examined as part of screening and to ensure eligibility for the study. Those","text_display":"\n\nSubjects will be clinically examined as part of screening and to ensure eligibility for the study. Those","confidence":1,"confidence_rate":1},{"cnt":[[146,2479],[1927,2479],[1927,2520],[146,2520]],"region":{"top_left_x":146,"top_left_y":2479,"width":1782,"height":42},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92dacaf4c97e4a29b880397fcabf7f1b","type":"text","conversion_output":true,"text":"subjects who are candidates for and agree to undergo sling surgery and behavioral treatment for MUI will","text_display":" subjects who are candidates for and agree to undergo sling surgery and behavioral treatment for MUI will","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2415e4498c42411e8604a0ddc53382e4","type":"page_info","conversion_output":false,"text":"46","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3bb745a4856443868b5f3de620b442d1","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-47","page":47,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdb23691231a44deb5a11130b34598d0","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"629fc54ed93b4719ad8baaf2ba28a00e","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21dc6130c9bd42ccb96514e5e8c1aa0d","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a14879563cc472a996005df8f334810","type":"text","conversion_output":true,"text":"Confidential","text_display":"\n\nConfidential","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1931,260],[1931,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1786,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea833499cf9b478d9f187f96ba471de3","type":"text","conversion_output":true,"text":"be approached for enrollment into the trial. Clinical and research staff will describe the study in detail and","text_display":" be approached for enrollment into the trial. Clinical and research staff will describe the study in detail and","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[146,346],[146,302],[1957,305],[1957,349]],"region":{"top_left_x":146,"top_left_y":301,"width":1812,"height":49},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42c440360d364caeac6c79da44d32c3a","type":"text","conversion_output":true,"text":"answer any questions the subject may have. Written informed consent for trial participation will be obtained","text_display":" answer any questions the subject may have. Written informed consent for trial participation will be obtained","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[1923,348],[1923,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1777,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8eb80a3a891d4a2c9caecf057f151213","type":"text","conversion_output":true,"text":"at that time. A common template for the research informed consent form will be used by all of the clinical","text_display":" at that time. A common template for the research informed consent form will be used by all of the clinical","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1962,391],[1962,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1816,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b31dddff1aa42b8b37551b1d7ea0afa","type":"text","conversion_output":true,"text":"sites, modifying the content or format as necessary to meet the requirements of their respective institutional","text_display":" sites, modifying the content or format as necessary to meet the requirements of their respective institutional","confidence":1,"confidence_rate":1},{"cnt":[[146,434],[1888,434],[1888,479],[146,479]],"region":{"top_left_x":146,"top_left_y":433,"width":1743,"height":47},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aaaaa984d8f44f6b91f65e0a07d436a5","type":"text","conversion_output":true,"text":"human subjects committees. This protocol must be approved by the IRBs at the clinical sites and DCC","text_display":" human subjects committees. This protocol must be approved by the IRBs at the clinical sites and DCC","confidence":1,"confidence_rate":1},{"cnt":[[146,477],[640,477],[640,522],[146,522]],"region":{"top_left_x":146,"top_left_y":476,"width":495,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97e474d99d76485eabc3ceeb0138a86f","type":"text","conversion_output":true,"text":"before study implementation.","text_display":" before study implementation.","confidence":1,"confidence_rate":1},{"cnt":[[142,606],[733,606],[733,655],[142,655]],"region":{"top_left_x":141,"top_left_y":605,"width":592,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0eecae365a04588ab79b396265d8bac","type":"section_header","conversion_output":false,"children_ids":["8363d769536348738850d070d1e52762"],"text":"","text_display":""},{"cnt":[[146,610],[728,610],[728,651],[146,651]],"region":{"top_left_x":146,"top_left_y":610,"width":583,"height":41},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8363d769536348738850d070d1e52762","type":"text","conversion_output":true,"parent_id":"c0eecae365a04588ab79b396265d8bac","text":"7.3. Data Safety Monitoring Board","text_display":"\n\n\\subsection*{7.3. Data Safety Monitoring Board}","confidence":0.96142578125,"confidence_rate":0.9989653275504088},{"cnt":[[146,662],[1927,662],[1927,707],[146,707]],"region":{"top_left_x":146,"top_left_y":661,"width":1782,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c5d1fd7ac3f4230bfa74a6823105fd5","type":"text","conversion_output":true,"text":"The National Institutes of Health has set up a Data Safety Monitoring Board (DSMB) to oversee all PFDN","text_display":"\n\nThe National Institutes of Health has set up a Data Safety Monitoring Board (DSMB) to oversee all PFDN","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[146,707],[1830,707],[1830,750],[146,750]],"region":{"top_left_x":146,"top_left_y":706,"width":1685,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80862c63238044c082b830f4b72e2c36","type":"text","conversion_output":true,"text":"studies, including this study. Members of the DSMB are independent of the study investigators and","text_display":" studies, including this study. Members of the DSMB are independent of the study investigators and","confidence":1,"confidence_rate":1},{"cnt":[[146,752],[1895,752],[1895,795],[146,795]],"region":{"top_left_x":146,"top_left_y":751,"width":1749,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a506ddb5f1043cabba694610d9113e2","type":"text","conversion_output":true,"text":"represent Urology, Urogynecology and Biostatistics, as well as having a lay member. The DSMB meets","text_display":" represent Urology, Urogynecology and Biostatistics, as well as having a lay member. The DSMB meets","confidence":1,"confidence_rate":1},{"cnt":[[146,795],[1916,795],[1916,838],[146,838]],"region":{"top_left_x":146,"top_left_y":794,"width":1771,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86c212f2141c4683a9624a0f40462c46","type":"text","conversion_output":true,"text":"every 3 months, or more frequently if requested by the Chair, either in person or by teleconference. This","text_display":" every 3 months, or more frequently if requested by the Chair, either in person or by teleconference. This","confidence":1,"confidence_rate":1},{"cnt":[[146,838],[1927,838],[1927,883],[146,883]],"region":{"top_left_x":146,"top_left_y":837,"width":1782,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93cef881b4004dbcaf79164fd12fde5f","type":"text","conversion_output":true,"text":"protocol has been approved by the DSMB prior to implementation. Safety outcomes will be assessed in a","text_display":" protocol has been approved by the DSMB prior to implementation. Safety outcomes will be assessed in a","confidence":1,"confidence_rate":1},{"cnt":[[146,881],[1893,881],[1893,926],[146,926]],"region":{"top_left_x":146,"top_left_y":880,"width":1747,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"069f3237a041453bad6663294b2ceb17","type":"text","conversion_output":true,"text":"descriptive manner at each DSMB meeting without formal statistical tests. This will include the need for","text_display":" descriptive manner at each DSMB meeting without formal statistical tests. This will include the need for","confidence":1,"confidence_rate":1},{"cnt":[[146,924],[1923,924],[1923,971],[146,971]],"region":{"top_left_x":146,"top_left_y":923,"width":1777,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"395ad2618c644c7d80f0a8942fb8af0a","type":"text","conversion_output":true,"text":"sling revision due to worsening OAB symptoms. There is no established stopping rule to guide what sling","text_display":" sling revision due to worsening OAB symptoms. There is no established stopping rule to guide what sling","confidence":0.8181660175323486,"confidence_rate":0.9982411100004835},{"cnt":[[146,971],[1450,971],[1450,1016],[146,1016]],"region":{"top_left_x":146,"top_left_y":971,"width":1305,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8582eff5aa7e4ea0a3df0e47ffec99ac","type":"text","conversion_output":true,"text":"revision rate is \"appropriate\" for worsening OAB symptoms in this population.","text_display":" revision rate is \"appropriate\" for worsening OAB symptoms in this population.","confidence":0.9692673683166504,"confidence_rate":0.9996194043564234},{"cnt":[[142,1096],[844,1096],[844,1145],[142,1145]],"region":{"top_left_x":141,"top_left_y":1095,"width":704,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3e4de21b30a445a80f8f12e8c769a6d","type":"section_header","conversion_output":false,"children_ids":["5ff68814b511493f991b36fae6931213"],"text":"","text_display":""},{"cnt":[[146,1100],[840,1100],[840,1141],[146,1141]],"region":{"top_left_x":146,"top_left_y":1100,"width":695,"height":41},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ff68814b511493f991b36fae6931213","type":"text","conversion_output":true,"parent_id":"d3e4de21b30a445a80f8f12e8c769a6d","text":"7.4. Reporting of serious adverse events","text_display":"\n\n\\subsection*{7.4. Reporting of serious adverse events}","confidence":1,"confidence_rate":1},{"cnt":[[146,1154],[1972,1154],[1972,1199],[146,1199]],"region":{"top_left_x":146,"top_left_y":1153,"width":1827,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb0565f12dfb4e578ae6a71f91601511","type":"text","conversion_output":true,"text":"Each clinical investigator is responsible for reporting serious adverse events (SAEs) to the IRB per their IRB","text_display":"\n\nEach clinical investigator is responsible for reporting serious adverse events (SAEs) to the IRB per their IRB","confidence":1,"confidence_rate":1},{"cnt":[[146,1199],[1966,1199],[1966,1244],[146,1244]],"region":{"top_left_x":146,"top_left_y":1198,"width":1820,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e40275a4bb349cabe7a1cb86f336037","type":"text","conversion_output":true,"text":"guidelines at their institution, and to the DCC. The DCC Safety Specialist reviews and summarizes the SAE","text_display":" guidelines at their institution, and to the DCC. The DCC Safety Specialist reviews and summarizes the SAE","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[146,1242],[993,1242],[993,1287],[146,1287]],"region":{"top_left_x":146,"top_left_y":1241,"width":847,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70ba7c099df34946ac761beef97f9bfc","type":"text","conversion_output":true,"text":"per DCC SAE reporting procedures for the PFDN.","text_display":" per DCC SAE reporting procedures for the PFDN.","confidence":1,"confidence_rate":1},{"cnt":[[144,1323],[492,1323],[492,1371],[144,1371]],"region":{"top_left_x":143,"top_left_y":1323,"width":349,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06ce8bd166884965bc1b627dfed72b31","type":"section_header","conversion_output":false,"children_ids":["f20a1ab1c7334b5db2c50d8241c1c97a"],"text":"","text_display":""},{"cnt":[[146,1328],[492,1328],[492,1369],[146,1369]],"region":{"top_left_x":146,"top_left_y":1327,"width":346,"height":42},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f20a1ab1c7334b5db2c50d8241c1c97a","type":"text","conversion_output":true,"parent_id":"06ce8bd166884965bc1b627dfed72b31","text":"7.5. Adverse events","text_display":"\n\n\\subsection*{7.5. Adverse events}","confidence":1,"confidence_rate":1},{"cnt":[[271,1384],[1944,1384],[1944,1429],[271,1429]],"region":{"top_left_x":270,"top_left_y":1383,"width":1675,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"439eb2f2a5a6453e8fe84498b628aa20","type":"text","conversion_output":true,"text":"Adverse events are defined as untoward medical events that are temporally-related to participation","text_display":"\n\nAdverse events are defined as untoward medical events that are temporally-related to participation","confidence":1,"confidence_rate":1},{"cnt":[[146,1427],[1867,1427],[1867,1472],[146,1472]],"region":{"top_left_x":146,"top_left_y":1426,"width":1721,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de242ec5646049e0acb636e8926bf0e4","type":"text","conversion_output":true,"text":"in a clinical study, regardless of whether they are causally-related to the study. Adverse events will be","text_display":" in a clinical study, regardless of whether they are causally-related to the study. Adverse events will be","confidence":1,"confidence_rate":1},{"cnt":[[146,1470],[1629,1470],[1629,1515],[146,1515]],"region":{"top_left_x":146,"top_left_y":1469,"width":1483,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a91f25ec2494f788b9d2915aabaf021","type":"text","conversion_output":true,"text":"collected during the course of this study and reported to the DSMB as described above.","text_display":" collected during the course of this study and reported to the DSMB as described above.","confidence":1,"confidence_rate":1},{"cnt":[[271,1512],[1966,1512],[1966,1558],[271,1558]],"region":{"top_left_x":270,"top_left_y":1512,"width":1696,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ac587b9785040e791276c3398054d67","type":"text","conversion_output":true,"text":"Sling surgery is a commonly performed operation for the treatment of SUI and MUI. Like all surgical","text_display":"\n\nSling surgery is a commonly performed operation for the treatment of SUI and MUI. Like all surgical","confidence":0.99951171875,"confidence_rate":0.9999953038523913},{"cnt":[[146,1555],[1957,1555],[1957,1603],[146,1603]],"region":{"top_left_x":146,"top_left_y":1555,"width":1812,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49fe233c46b64adb8543e1b366babb5d","type":"text","conversion_output":true,"text":"interventions it has the risk of bleeding, infection, and injury to surrounding structures. In addition, the sling","text_display":" interventions it has the risk of bleeding, infection, and injury to surrounding structures. In addition, the sling","confidence":1,"confidence_rate":1},{"cnt":[[146,1601],[1904,1601],[1904,1646],[146,1646]],"region":{"top_left_x":146,"top_left_y":1600,"width":1758,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccb515ff20f94c43bd572f98995e0f12","type":"text","conversion_output":true,"text":"procedure utilizes polypropylene mesh which can introduce additional risk of mesh complication. These","text_display":" procedure utilizes polypropylene mesh which can introduce additional risk of mesh complication. These","confidence":1,"confidence_rate":1},{"cnt":[[146,1646],[1863,1646],[1863,1691],[146,1691]],"region":{"top_left_x":146,"top_left_y":1645,"width":1717,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5950c1c4efec4632ab19bd75f0dcc82f","type":"text","conversion_output":true,"text":"include vaginal mesh extrusion, mesh infection, and bladder or urethral mesh erosion. Complications","text_display":" include vaginal mesh extrusion, mesh infection, and bladder or urethral mesh erosion. Complications","confidence":1,"confidence_rate":1},{"cnt":[[146,1689],[1888,1689],[1888,1734],[146,1734]],"region":{"top_left_x":146,"top_left_y":1688,"width":1743,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c5866f0c11e4c8f8bc24eae78b08253","type":"text","conversion_output":true,"text":"specific to sling placement include bladder perforation, retropubic hematoma, obturator nerve or vessel","text_display":" specific to sling placement include bladder perforation, retropubic hematoma, obturator nerve or vessel","confidence":1,"confidence_rate":1},{"cnt":[[146,1732],[1972,1732],[1972,1777],[146,1777]],"region":{"top_left_x":146,"top_left_y":1731,"width":1827,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"451b131a8bc1482c8ce551be1bbb351e","type":"text","conversion_output":true,"text":"injury, groin pain, worsening incontinence, and worsening OAB. The FDA has recently issued guidelines on","text_display":" injury, groin pain, worsening incontinence, and worsening OAB. The FDA has recently issued guidelines on","confidence":0.9736328125,"confidence_rate":0.9997548829301576},{"cnt":[[146,1777],[1813,1777],[1813,1824],[146,1824]],"region":{"top_left_x":146,"top_left_y":1776,"width":1668,"height":49},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"531d9c656c7d4d7185b577480fa32bd5","type":"text","conversion_output":true,"text":"the use of surgical mesh and has recommended it only be used by trained surgeons. All surgeons","text_display":" the use of surgical mesh and has recommended it only be used by trained surgeons. All surgeons","confidence":1,"confidence_rate":1},{"cnt":[[146,1822],[1381,1822],[1381,1867],[146,1867]],"region":{"top_left_x":146,"top_left_y":1821,"width":1236,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea5b185544994f4f8abdc32a1105bea4","type":"text","conversion_output":true,"text":"participating in this study will be specifically trained to use surgical mesh.","text_display":" participating in this study will be specifically trained to use surgical mesh.","confidence":1,"confidence_rate":1},{"cnt":[[144,1946],[385,1946],[385,1996],[144,1996]],"region":{"top_left_x":143,"top_left_y":1946,"width":242,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18e9a68d2676468ca9746918999c4f29","type":"section_header","conversion_output":false,"children_ids":["0c55f53d477245bdbe467152bb93ba98"],"text":"","text_display":""},{"cnt":[[146,1951],[382,1951],[382,1996],[146,1996]],"region":{"top_left_x":146,"top_left_y":1950,"width":237,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c55f53d477245bdbe467152bb93ba98","type":"text","conversion_output":true,"parent_id":"18e9a68d2676468ca9746918999c4f29","text":"8. Feasibility","text_display":"\n\n\\section*{8. Feasibility}","confidence":1,"confidence_rate":1},{"cnt":[[271,2002],[1893,2002],[1893,2047],[271,2047]],"region":{"top_left_x":270,"top_left_y":2002,"width":1623,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bf8b409149c49e8bfcc7fb6a506c6cb","type":"text","conversion_output":true,"text":"The proposed study population has already chosen to undergo surgical treatment and the BPTx","text_display":"\n\nThe proposed study population has already chosen to undergo surgical treatment and the BPTx","confidence":1,"confidence_rate":1},{"cnt":[[146,2050],[1940,2050],[1940,2093],[146,2093]],"region":{"top_left_x":146,"top_left_y":2049,"width":1795,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7e7df57059d47239b7cf32f60367b2f","type":"text","conversion_output":true,"text":"intervention is low risk. We have taken care to have comparable arms in a clinical efficacy trial design with","text_display":" intervention is low risk. We have taken care to have comparable arms in a clinical efficacy trial design with","confidence":0.9975595474243164,"confidence_rate":0.9999785665864189},{"cnt":[[146,2093],[1979,2093],[1979,2138],[146,2138]],"region":{"top_left_x":146,"top_left_y":2092,"width":1833,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"933f18958a2e40f0abc571db0abf5a13","type":"text","conversion_output":true,"text":"inclusion criteria that are not overly-strict; therefore, we do not anticipate particular difficulty in recruitment of","text_display":" inclusion criteria that are not overly-strict; therefore, we do not anticipate particular difficulty in recruitment of","confidence":1,"confidence_rate":1},{"cnt":[[146,2136],[1936,2136],[1936,2183],[146,2183]],"region":{"top_left_x":146,"top_left_y":2135,"width":1790,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2227124f4e0a4b31a439dd6b58d599ba","type":"text","conversion_output":true,"text":"MUI patients as encountered in MIMOSA. \\({ }^{37}\\) If needed in the postoperative period, medical therapy will not","text_display":" MUI patients as encountered in MIMOSA. \\({ }^{37}\\) If needed in the postoperative period, medical therapy will not","confidence":1,"confidence_rate":1},{"cnt":[[146,2179],[1893,2179],[1893,2224],[146,2224]],"region":{"top_left_x":146,"top_left_y":2178,"width":1747,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cd6e95b85aa440181d219f46a55edb2","type":"text","conversion_output":true,"text":"be withheld after 3 months postoperative. Women reporting bothersome OAB symptoms for which they","text_display":" be withheld after 3 months postoperative. Women reporting bothersome OAB symptoms for which they","confidence":1,"confidence_rate":1},{"cnt":[[146,2224],[1878,2224],[1878,2271],[146,2271]],"region":{"top_left_x":146,"top_left_y":2223,"width":1732,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3583b0f2f08f4f48925e84f121cdbcf1","type":"text","conversion_output":true,"text":"desire additional treatment will be presented their options (additional BPTx and/or FDA approved OAB","text_display":" desire additional treatment will be presented their options (additional BPTx and/or FDA approved OAB","confidence":1,"confidence_rate":1},{"cnt":[[146,2269],[1962,2269],[1962,2314],[146,2314]],"region":{"top_left_x":146,"top_left_y":2268,"width":1816,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e4e9179f11845fc9c753897d9bce217","type":"text","conversion_output":true,"text":"pharmacologic therapy, or other procedures or surgeries), and additional treatment will be offered. Request","text_display":" pharmacologic therapy, or other procedures or surgeries), and additional treatment will be offered. Request","confidence":1,"confidence_rate":1},{"cnt":[[146,2312],[1858,2312],[1858,2357],[146,2357]],"region":{"top_left_x":146,"top_left_y":2311,"width":1713,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5989ff8b524f453f84145adff7b01cae","type":"text","conversion_output":true,"text":"for additional treatment for either OAB or SUI postoperatively will be driven by patient preference and","text_display":" for additional treatment for either OAB or SUI postoperatively will be driven by patient preference and","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[146,2355],[720,2355],[720,2400],[146,2400]],"region":{"top_left_x":146,"top_left_y":2354,"width":574,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dceb00fe533f4e87adeea22bcba887c5","type":"text","conversion_output":true,"text":"clinician judgment in both groups.","text_display":" clinician judgment in both groups.","confidence":1,"confidence_rate":1},{"cnt":[[1036,2548],[1089,2548],[1089,2593],[1036,2593]],"region":{"top_left_x":1035,"top_left_y":2548,"width":55,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a894a5bb529c4822a8adf6a34d91b98f","type":"page_info","conversion_output":false,"text":"47","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63d50c12cc5a4bec8a2753b769bc98c9","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-48","page":48,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f64ca5d7d4f34f1c8bab176fde8ab639","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1f12b0f04fa450daf684c809cac5bf1","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a80dad9e9184aecace49fdf472abbbb","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,254],[146,254]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":40},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7c6197fd1c04335a47204af580095b5","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[144,348],[402,348],[402,393],[144,393]],"region":{"top_left_x":143,"top_left_y":348,"width":259,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b49cf7b9c824662b7f4379445b1cac5","type":"section_header","conversion_output":false,"children_ids":["b2348cfc65ce4aba969b2b94ca14101a"],"text":"","text_display":""},{"cnt":[[146,352],[402,352],[402,389],[146,389]],"region":{"top_left_x":146,"top_left_y":352,"width":256,"height":37},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2348cfc65ce4aba969b2b94ca14101a","type":"text","conversion_output":true,"parent_id":"8b49cf7b9c824662b7f4379445b1cac5","text":"9. References","text_display":"\n\n\\section*{9. References}","confidence":1,"confidence_rate":1},{"cnt":[[148,455],[1886,455],[1886,501],[148,501]],"region":{"top_left_x":148,"top_left_y":455,"width":1739,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6ab4ecf4f664cc49b43d0973904e2e5","type":"text","conversion_output":true,"text":"1. Katsumi HK, Rutman MP. Can we predict if overactive bladder symptoms will resolve after sling","text_display":"\n1. Katsumi HK, Rutman MP. Can we predict if overactive bladder symptoms will resolve after sling","confidence":1,"confidence_rate":1},{"cnt":[[146,498],[1454,498],[1454,544],[146,544]],"region":{"top_left_x":146,"top_left_y":498,"width":1309,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e48d73d408104fadac241a20067f284e","type":"text","conversion_output":true,"text":"surgery in women with mixed urinary incontinence? Curr Urol Rep;11:328-37.","text_display":" surgery in women with mixed urinary incontinence? Curr Urol Rep;11:328-37.","confidence":1,"confidence_rate":1},{"cnt":[[146,541],[1979,541],[1979,587],[146,587]],"region":{"top_left_x":146,"top_left_y":541,"width":1833,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a23323e99164a1fba6a7b3c34ef4f0a","type":"text","conversion_output":true,"text":"2. Shumaker SA, Wyman JF, Uebersax JS, McClish D, Fantl JA. Health-related quality of life measures","text_display":"\n2. Shumaker SA, Wyman JF, Uebersax JS, McClish D, Fantl JA. Health-related quality of life measures","confidence":1,"confidence_rate":1},{"cnt":[[146,589],[1910,589],[1910,632],[146,632]],"region":{"top_left_x":146,"top_left_y":588,"width":1764,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2bf1866e1d04951815346bf584875b8","type":"text","conversion_output":true,"text":"for women with urinary incontinence: the Incontinence Impact Questionnaire and the Urogenital Distress","text_display":" for women with urinary incontinence: the Incontinence Impact Questionnaire and the Urogenital Distress","confidence":1,"confidence_rate":1},{"cnt":[[146,632],[1820,632],[1820,677],[146,677]],"region":{"top_left_x":146,"top_left_y":631,"width":1674,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc5b263d4ed048f0a41b92c1bb12930c","type":"text","conversion_output":true,"text":"Inventory. Continence Program in Women (CPW) Research Group. Qual Life Res 1994;3:291-306.","text_display":" Inventory. Continence Program in Women (CPW) Research Group. Qual Life Res 1994;3:291-306.","confidence":1,"confidence_rate":1},{"cnt":[[146,675],[1972,675],[1972,720],[146,720]],"region":{"top_left_x":146,"top_left_y":674,"width":1827,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3763e7042e9484e913d35e1474136fc","type":"text","conversion_output":true,"text":"3. Yalcin I, Bump RC. Validation of two global impression questionnaires for incontinence. Am J Obstet","text_display":"\n3. Yalcin I, Bump RC. Validation of two global impression questionnaires for incontinence. Am J Obstet","confidence":1,"confidence_rate":1},{"cnt":[[146,718],[604,718],[604,763],[146,763]],"region":{"top_left_x":146,"top_left_y":717,"width":458,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"372e9f96e6b5417a8556d639702a4995","type":"text","conversion_output":true,"text":"Gynecol 2003;189:98-101.","text_display":" Gynecol 2003;189:98-101.","confidence":1,"confidence_rate":1},{"cnt":[[146,761],[1962,761],[1962,806],[146,806]],"region":{"top_left_x":146,"top_left_y":760,"width":1816,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c7185b27e904c0e9092ca425b901bfb","type":"text","conversion_output":true,"text":"4. Melville JL, Katon W, Delaney K, Newton K. Urinary incontinence in US women: a population-based","text_display":"\n4. Melville JL, Katon W, Delaney K, Newton K. 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(Elkardy, 2003;","text_display":" floor disorders, patient goals and expectations vary and are linked to treatment satisfaction. (Elkardy, 2003;","confidence":1,"confidence_rate":1},{"cnt":[[146,1577],[1914,1577],[1914,1622],[146,1622]],"region":{"top_left_x":146,"top_left_y":1576,"width":1769,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8600dead821449a9b53755297642351","type":"text","conversion_output":true,"text":"Hullfish 2004; Komesu 2008) Conversely, unmet goals are closely associated with patient dissatisfaction","text_display":" Hullfish 2004; Komesu 2008) Conversely, unmet goals are closely associated with patient dissatisfaction","confidence":1,"confidence_rate":1},{"cnt":[[146,1620],[1949,1620],[1949,1665],[146,1665]],"region":{"top_left_x":146,"top_left_y":1619,"width":1803,"height":47},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee0f3d4519be4baf8b11918f30f9a0a1","type":"text","conversion_output":true,"text":"after treatment. (Elkardy, 2003; Hullfish 2004; Komesu 2008) Despite the importance of individualized goal","text_display":" after treatment. (Elkardy, 2003; Hullfish 2004; Komesu 2008) Despite the importance of individualized goal","confidence":1,"confidence_rate":1},{"cnt":[[146,1663],[1940,1663],[1940,1708],[146,1708]],"region":{"top_left_x":146,"top_left_y":1662,"width":1795,"height":47},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"450e2b9c57f14d8f9ef92a6da7993cfe","type":"text","conversion_output":true,"text":"setting, prior goal attainment scaling studies in urogynecology are limited by inclusion of small numbers of","text_display":" setting, prior goal attainment scaling studies in urogynecology are limited by inclusion of small numbers of","confidence":1,"confidence_rate":1},{"cnt":[[146,1710],[1899,1710],[1899,1755],[146,1755]],"region":{"top_left_x":146,"top_left_y":1710,"width":1754,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6cafe03381c4f43b4fb2d0885f950e8","type":"text","conversion_output":true,"text":"women with an array of pelvic floor dysfunction, lack of assessment of the difference between short and","text_display":" women with an array of pelvic floor dysfunction, lack of assessment of the difference between short and","confidence":1,"confidence_rate":1},{"cnt":[[146,1753],[1966,1753],[1966,1798],[146,1798]],"region":{"top_left_x":146,"top_left_y":1753,"width":1820,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14352a2a8338402b9e9b3361a8e6f4bc","type":"text","conversion_output":true,"text":"long term goals, and have not consistently followed women after treatment to determine whether their goals","text_display":" long term goals, and have not consistently followed women after treatment to determine whether their goals","confidence":1,"confidence_rate":1},{"cnt":[[146,1796],[1775,1796],[1775,1841],[146,1841]],"region":{"top_left_x":146,"top_left_y":1796,"width":1629,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4963a842076e48088d30e7826b927069","type":"text","conversion_output":true,"text":"are achieved. A key gap in our understanding of mixed urinary incontinence and women's","text_display":" are achieved. A key gap in our understanding of mixed urinary incontinence and women's","confidence":0.9931640625,"confidence_rate":0.9999246247139267},{"cnt":[[146,1839],[1951,1839],[1951,1884],[146,1884]],"region":{"top_left_x":146,"top_left_y":1839,"width":1805,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdd80dfb56644cb08dc782f1f1aab0de","type":"text","conversion_output":true,"text":"expectations following treatment is accurate goal characterization and determination of whether or","text_display":" expectations following treatment is accurate goal characterization and determination of whether or","confidence":0.9951226694975048,"confidence_rate":0.999952532548989},{"cnt":[[146,1884],[1974,1884],[1974,1929],[146,1929]],"region":{"top_left_x":146,"top_left_y":1884,"width":1829,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62e02d0370f94970990d4f8217169292","type":"text","conversion_output":true,"text":"not goals are attained in the short and long term following treatment. ESTEEM provides an ideal study","text_display":" not goals are attained in the short and long term following treatment. ESTEEM provides an ideal study","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[146,1929],[823,1929],[823,1974],[146,1974]],"region":{"top_left_x":146,"top_left_y":1929,"width":677,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbcfdf8ca87841dfb9af78527e33b58c","type":"text","conversion_output":true,"text":"setting in which to answer this question.","text_display":" setting in which to answer this question.","confidence":1,"confidence_rate":1},{"cnt":[[208,2015],[1916,2015],[1916,2060],[208,2060]],"region":{"top_left_x":208,"top_left_y":2015,"width":1709,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82d9dbd41d8740fdbc47f8cf9f9c50e1","type":"text","conversion_output":true,"text":"ESTEEM will compare the effect of peri-operative behavioral/pelvic floor therapy (BPTx) plus MUS to","text_display":"\n\nESTEEM will compare the effect of peri-operative behavioral/pelvic floor therapy (BPTx) plus MUS to","confidence":1,"confidence_rate":1},{"cnt":[[146,2058],[1828,2058],[1828,2103],[146,2103]],"region":{"top_left_x":146,"top_left_y":2058,"width":1683,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a564f8bfd0d470eabab23b79979c7f7","type":"text","conversion_output":true,"text":"MUS alone on MUI treatment in 472 women. This trial provides an ideal setting in which to describe","text_display":" MUS alone on MUI treatment in 472 women. This trial provides an ideal setting in which to describe","confidence":1,"confidence_rate":1},{"cnt":[[146,2103],[1957,2103],[1957,2151],[146,2151]],"region":{"top_left_x":146,"top_left_y":2103,"width":1812,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0928118a2d04a5c97cccf1a8d037b13","type":"text","conversion_output":true,"text":"individualized goals for MUI treatment as well as the importance of goal attainment on women's impression","text_display":" individualized goals for MUI treatment as well as the importance of goal attainment on women's impression","confidence":1,"confidence_rate":1},{"cnt":[[146,2148],[1979,2148],[1979,2194],[146,2194]],"region":{"top_left_x":146,"top_left_y":2148,"width":1833,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53052e7470624d70bd44c8505373e828","type":"text","conversion_output":true,"text":"of cure. This, in turn, will enable providers to ultimately negotiate expectations so that providers and patients","text_display":" of cure. This, in turn, will enable providers to ultimately negotiate expectations so that providers and patients","confidence":1,"confidence_rate":1},{"cnt":[[146,2191],[1910,2191],[1910,2237],[146,2237]],"region":{"top_left_x":146,"top_left_y":2191,"width":1764,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b6840a6a063401eafe307b2d788d45f","type":"text","conversion_output":true,"text":"have better communication regarding the benefits and limitations of various treatments for mixed urinary","text_display":" have better communication regarding the benefits and limitations of various treatments for mixed urinary","confidence":1,"confidence_rate":1},{"cnt":[[146,2234],[1957,2234],[1957,2279],[146,2279]],"region":{"top_left_x":146,"top_left_y":2234,"width":1812,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4dc6617a3e25444aa7f92cdf50ca2c3d","type":"text","conversion_output":true,"text":"incontinence. The long-term goal of this supplementary study to ESTEEM is to better understand patient","text_display":" incontinence. The long-term goal of this supplementary study to ESTEEM is to better understand patient","confidence":1,"confidence_rate":1},{"cnt":[[146,2277],[1953,2277],[1953,2322],[146,2322]],"region":{"top_left_x":146,"top_left_y":2277,"width":1807,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f926b4f854e4496bbad200935a65567b","type":"text","conversion_output":true,"text":"expectations following treatment for MUI in order to provide patients and providers an informed platform","text_display":" expectations following treatment for MUI in order to provide patients and providers an informed platform","confidence":1,"confidence_rate":1},{"cnt":[[146,2322],[1921,2322],[1921,2368],[146,2368]],"region":{"top_left_x":146,"top_left_y":2322,"width":1775,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ee16fc76cab45bfb9c68249560cd7ef","type":"text","conversion_output":true,"text":"for discussion of treatment options and realistic outcome expectations. The objectives of this proposal","text_display":" for discussion of treatment options and realistic outcome expectations. The objectives of this proposal","confidence":1,"confidence_rate":1},{"cnt":[[146,2368],[1936,2368],[1936,2413],[146,2413]],"region":{"top_left_x":146,"top_left_y":2367,"width":1790,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c2cddc3334c4571b0a3adb50de3781d","type":"text","conversion_output":true,"text":"are to describe patient centered goals among a group of women with MUI undergoing midurethral sling","text_display":" are to describe patient centered goals among a group of women with MUI undergoing midurethral sling","confidence":1,"confidence_rate":1},{"cnt":[[146,2411],[1863,2411],[1863,2456],[146,2456]],"region":{"top_left_x":146,"top_left_y":2410,"width":1717,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ea453fd0eee448cb2184784191f06a1","type":"text","conversion_output":true,"text":"surgery with and without BPTx as well as determine whether or not these goals were met following","text_display":" surgery with and without BPTx as well as determine whether or not these goals were met following","confidence":1,"confidence_rate":1},{"cnt":[[146,2454],[1968,2454],[1968,2499],[146,2499]],"region":{"top_left_x":146,"top_left_y":2453,"width":1822,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5428856727a44bec9872c53b83cb05d1","type":"text","conversion_output":true,"text":"treatment using the validated Self-Assessment Goal Achievement (SAGA) questionnaire. Our expectation","text_display":" treatment using the validated Self-Assessment Goal Achievement (SAGA) questionnaire. Our expectation","confidence":1,"confidence_rate":1},{"cnt":[[146,2499],[1974,2499],[1974,2546],[146,2546]],"region":{"top_left_x":146,"top_left_y":2498,"width":1829,"height":48},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34a9818f268945d9abc9bf4572b1e4f5","type":"text","conversion_output":true,"text":"is that a better understanding of individualized patient goals will improve patient-provider communication,","text_display":" is that a better understanding of individualized patient goals will improve patient-provider communication,","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd8b4bd5d89d40b8bd07f2953e7d7488","type":"page_info","conversion_output":false,"text":"54","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b5c7a5cc2a74b7ead299ac2aecb61f7","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-55","page":55,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c18d1c24e34943bc926cedac03142a29","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"224319056c23469793d4d1475a0e57cd","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8dd8a03b15b48089bd4d2651a8e146e","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b00b7e86e754b40a29feb4b4acb4013","type":"page_info","conversion_output":false,"text":"Confidential","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1815,260],[1815,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1670,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"515bec728a834ba28a6efcc148d0a844","type":"text","conversion_output":true,"text":"and provide a unique aspect of patient reported outcomes not currently measured with standard","text_display":"\nand provide a unique aspect of patient reported outcomes not currently measured with standard","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[956,305],[956,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":811,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4cb35b78d93422ea42e3c0736e634af","type":"text","conversion_output":true,"text":"symptom severity and quality of life measures.","text_display":" symptom severity and quality of life measures.","confidence":1,"confidence_rate":1},{"cnt":[[211,348],[1962,348],[1962,391],[211,391]],"region":{"top_left_x":210,"top_left_y":348,"width":1752,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be4073fe472b4ff1939faea94220b45f","type":"text","conversion_output":true,"text":"Aim 1: To describe patient reported goals and goal ranking among women consenting to ESTEEM. We","text_display":"\n\nAim 1: To describe patient reported goals and goal ranking among women consenting to ESTEEM. We","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1893,391],[1893,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1747,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01a588181fd5423aa858c66887c7e4e5","type":"text","conversion_output":true,"text":"hypothesize that women's goals vary and are not currently captured by standard symptom severity and","text_display":" hypothesize that women's goals vary and are not currently captured by standard symptom severity and","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[148,438],[419,438],[419,475],[148,475]],"region":{"top_left_x":148,"top_left_y":438,"width":271,"height":37},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef35e666d3b24c7688e1862c54a80826","type":"text","conversion_output":true,"text":"QOL measures.","text_display":" QOL measures.","confidence":1,"confidence_rate":1},{"cnt":[[208,479],[1966,479],[1966,522],[208,522]],"region":{"top_left_x":208,"top_left_y":479,"width":1758,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"060bcbdd99cf4e258dbc1408683195a0","type":"text","conversion_output":true,"text":"Aim 2: To determine whether or not women achieve self-reported goals following treatment for MUI and","text_display":"\n\nAim 2: To determine whether or not women achieve self-reported goals following treatment for MUI and","confidence":1,"confidence_rate":1},{"cnt":[[146,524],[1878,524],[1878,567],[146,567]],"region":{"top_left_x":146,"top_left_y":524,"width":1732,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13dcc28cc1d04cf9898e6db2ec2d9ab6","type":"text","conversion_output":true,"text":"to compare those who achieve their goals to those who do not in both the intermediate ( 6 months) and","text_display":" to compare those who achieve their goals to those who do not in both the intermediate ( 6 months) and","confidence":0.9566240310668945,"confidence_rate":0.9995932494727853},{"cnt":[[146,567],[1901,567],[1901,612],[146,612]],"region":{"top_left_x":146,"top_left_y":567,"width":1756,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2715873215543d5b668eb175b091621","type":"text","conversion_output":true,"text":"longer term ( 12 months). We hypothesize that women who report and rank continence related goals are","text_display":" longer term ( 12 months). We hypothesize that women who report and rank continence related goals are","confidence":0.6403121948242188,"confidence_rate":0.9958807351616056},{"cnt":[[146,610],[1938,610],[1938,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1792,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58bd964a0ed6449bad6afdd815df49e7","type":"text","conversion_output":true,"text":"more likely to achieve those goals than goals related to general health and specific activities and that goal","text_display":" more likely to achieve those goals than goals related to general health and specific activities and that goal","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[960,655],[960,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":815,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c474ade9c1b34badaae5954dbc600688","type":"text","conversion_output":true,"text":"achievement is related to patient's PGI-I scores.","text_display":" achievement is related to patient's PGI-I scores.","confidence":1,"confidence_rate":1},{"cnt":[[146,698],[1972,698],[1972,741],[146,741]],"region":{"top_left_x":146,"top_left_y":698,"width":1827,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c616cf122f7d4891af2d5240d52218f3","type":"text","conversion_output":true,"text":"Significance: PROs are critical to the assessment of pelvic floor dysfunction, yet standardized measures of","text_display":"\nSignificance: PROs are critical to the assessment of pelvic floor dysfunction, yet standardized measures of","confidence":1,"confidence_rate":1},{"cnt":[[146,743],[1955,743],[1955,786],[146,786]],"region":{"top_left_x":146,"top_left_y":743,"width":1810,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e012217c1eb4e2bb9bfeef8067ee651","type":"text","conversion_output":true,"text":"symptom severity and quality of life may not capture an individual women's motivation and expectations for","text_display":" symptom severity and quality of life may not capture an individual women's motivation and expectations for","confidence":1,"confidence_rate":1},{"cnt":[[146,786],[1837,786],[1837,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1691,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23aa43cd7e9d4754b6548a2dada2509d","type":"text","conversion_output":true,"text":"seeking treatment. Goal attainment scaling is an established methodology of describing and ranking","text_display":" seeking treatment. Goal attainment scaling is an established methodology of describing and ranking","confidence":1,"confidence_rate":1},{"cnt":[[146,829],[1656,829],[1656,874],[146,874]],"region":{"top_left_x":146,"top_left_y":829,"width":1511,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d7121ea2f494e23905f6bb2397db275","type":"text","conversion_output":true,"text":"individual goals and has been used in a variety of fields including treatment of pelvic floor","text_display":" individual goals and has been used in a variety of fields including treatment of pelvic floor","confidence":1,"confidence_rate":1},{"cnt":[[146,872],[1949,872],[1949,917],[146,917]],"region":{"top_left_x":146,"top_left_y":872,"width":1803,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce7b81c3b6e0441984f6ce0920a857d8","type":"text","conversion_output":true,"text":"dysfunction.(Khuller, 2013) Goal attainment scaling offers unique insight into individual concerns regarding","text_display":" dysfunction.(Khuller, 2013) Goal attainment scaling offers unique insight into individual concerns regarding","confidence":0.99853515625,"confidence_rate":0.9999870273612914},{"cnt":[[146,920],[1972,920],[1972,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1827,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57ccd9dc628044bd80258b7b75ff5ff4","type":"text","conversion_output":true,"text":"common disorders, such as MUI. While it is known that the impact of pelvic floor dysfunction varies between","text_display":" common disorders, such as MUI. While it is known that the impact of pelvic floor dysfunction varies between","confidence":1,"confidence_rate":1},{"cnt":[[146,962],[1964,962],[1964,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":962,"width":1818,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6b8b054b4ae4941a3a4d0432475b6b4","type":"text","conversion_output":true,"text":"individuals with similar physiologic measures of disease, the underpinnings of what explains the differences","text_display":" individuals with similar physiologic measures of disease, the underpinnings of what explains the differences","confidence":1,"confidence_rate":1},{"cnt":[[146,1005],[1955,1005],[1955,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1005,"width":1810,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"855318cd82fc40c6b39cf4f02cfa83b9","type":"text","conversion_output":true,"text":"in bother and impact on quality of life are less well characterized. In addition, patient expectations are likely","text_display":" in bother and impact on quality of life are less well characterized. In addition, patient expectations are likely","confidence":1,"confidence_rate":1},{"cnt":[[146,1053],[1794,1053],[1794,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1052,"width":1648,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53b53b149cbc47059f17ccb85cf8294f","type":"text","conversion_output":true,"text":"to drive care seeking as well as adherence to treatment regimens and are, in turn, correlated with","text_display":" to drive care seeking as well as adherence to treatment regimens and are, in turn, correlated with","confidence":1,"confidence_rate":1},{"cnt":[[146,1096],[1904,1096],[1904,1139],[146,1139]],"region":{"top_left_x":146,"top_left_y":1095,"width":1758,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4823fc8ca8af47f883f63cb3c107ff67","type":"text","conversion_output":true,"text":"satisfaction with those treatment outcomes. MUI is a common disorder with lack of consensus regarding","text_display":" satisfaction with those treatment outcomes. MUI is a common disorder with lack of consensus regarding","confidence":1,"confidence_rate":1},{"cnt":[[146,1139],[1906,1139],[1906,1182],[146,1182]],"region":{"top_left_x":146,"top_left_y":1138,"width":1760,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dec00471da074498acd9e3dff908db29","type":"text","conversion_output":true,"text":"treatment; ESTEEM will test whether or not BPTx is beneficial prior to and following sling surgery. A key","text_display":" treatment; ESTEEM will test whether or not BPTx is beneficial prior to and following sling surgery. A key","confidence":1,"confidence_rate":1},{"cnt":[[146,1182],[1968,1182],[1968,1227],[146,1227]],"region":{"top_left_x":146,"top_left_y":1181,"width":1822,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ace5fd704ea4600bd3c77150946b570","type":"text","conversion_output":true,"text":"aspect of understanding women's satisfaction with these treatment options is determining the importance of","text_display":" aspect of understanding women's satisfaction with these treatment options is determining the importance of","confidence":1,"confidence_rate":1},{"cnt":[[146,1225],[1798,1225],[1798,1270],[146,1270]],"region":{"top_left_x":146,"top_left_y":1224,"width":1653,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4dbc46806649455b9986a159ad8b63e4","type":"text","conversion_output":true,"text":"various lower urinary tract symptoms to individuals and what individualized goals women have for","text_display":" various lower urinary tract symptoms to individuals and what individualized goals women have for","confidence":1,"confidence_rate":1},{"cnt":[[146,1268],[322,1268],[322,1308],[146,1308]],"region":{"top_left_x":146,"top_left_y":1267,"width":177,"height":42},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd74204275c74168937ea24870560fc9","type":"text","conversion_output":true,"text":"treatment.","text_display":" treatment.","confidence":1,"confidence_rate":1},{"cnt":[[146,1358],[1781,1358],[1781,1403],[146,1403]],"region":{"top_left_x":146,"top_left_y":1357,"width":1636,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2e00d948dd64045af2fdea98a658524","type":"text","conversion_output":true,"text":"Innovation: Mixed urinary incontinence is bothersome to women and often presents a treatment","text_display":"\n\nInnovation: Mixed urinary incontinence is bothersome to women and often presents a treatment","confidence":1,"confidence_rate":1},{"cnt":[[146,1401],[1977,1401],[1977,1446],[146,1446]],"region":{"top_left_x":146,"top_left_y":1400,"width":1831,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d64dd38b7fd4f989c5c898a3e20926a","type":"text","conversion_output":true,"text":"conundrum to providers. The symptom of urinary leakage is what concerns the patient most, yet the etiology","text_display":" conundrum to providers. The symptom of urinary leakage is what concerns the patient most, yet the etiology","confidence":1,"confidence_rate":1},{"cnt":[[146,1446],[1923,1446],[1923,1489],[146,1489]],"region":{"top_left_x":146,"top_left_y":1445,"width":1777,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15514bc723784cd48c2bcec96a0c9a3a","type":"text","conversion_output":true,"text":"of the UUI and SUI are thought to be different and the treatments for one may lead to exacerbation of the","text_display":" of the UUI and SUI are thought to be different and the treatments for one may lead to exacerbation of the","confidence":1,"confidence_rate":1},{"cnt":[[146,1489],[1910,1489],[1910,1534],[146,1534]],"region":{"top_left_x":146,"top_left_y":1488,"width":1764,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6bb64cf3c1f41258de74553f9bdb69c","type":"text","conversion_output":true,"text":"other. While ESTEEM will measure symptom severity and quality of life for both SUI and UUI symptoms,","text_display":" other. While ESTEEM will measure symptom severity and quality of life for both SUI and UUI symptoms,","confidence":1,"confidence_rate":1},{"cnt":[[146,1534],[1884,1534],[1884,1579],[146,1579]],"region":{"top_left_x":146,"top_left_y":1533,"width":1739,"height":47},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6818da774ec468f923bb9f2680c25af","type":"text","conversion_output":true,"text":"currently the protocol does not contain a measure of the importance of alleviating specific symptoms to","text_display":" currently the protocol does not contain a measure of the importance of alleviating specific symptoms to","confidence":1,"confidence_rate":1},{"cnt":[[146,1577],[1901,1577],[1901,1622],[146,1622]],"region":{"top_left_x":146,"top_left_y":1576,"width":1756,"height":47},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c43dcd254bca426e9171b3296a8bee11","type":"text","conversion_output":true,"text":"individual women. In addition, women participating in the trial likely have unique goals and concerns not","text_display":" individual women. In addition, women participating in the trial likely have unique goals and concerns not","confidence":1,"confidence_rate":1},{"cnt":[[146,1622],[1906,1622],[1906,1665],[146,1665]],"region":{"top_left_x":146,"top_left_y":1622,"width":1760,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75ed1d0b0d5f4b27b95e92071c7a94aa","type":"text","conversion_output":true,"text":"currently captured with standard symptom severity and quality of life measures presently included in this","text_display":" currently captured with standard symptom severity and quality of life measures presently included in this","confidence":1,"confidence_rate":1},{"cnt":[[146,1663],[1949,1663],[1949,1708],[146,1708]],"region":{"top_left_x":146,"top_left_y":1662,"width":1803,"height":47},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f6e370dd6974c83935c810c81665b5a","type":"text","conversion_output":true,"text":"study. Inclusion of the SAGA questionnaire at baseline, six months and one year after MUS with or without","text_display":" study. Inclusion of the SAGA questionnaire at baseline, six months and one year after MUS with or without","confidence":1,"confidence_rate":1},{"cnt":[[146,1710],[1936,1710],[1936,1755],[146,1755]],"region":{"top_left_x":146,"top_left_y":1710,"width":1790,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2ed6941885f48fd9386ac756fb81586","type":"text","conversion_output":true,"text":"BPTx will offer the PFDN the opportunity to characterize treatment goals in a large number of women with","text_display":" BPTx will offer the PFDN the opportunity to characterize treatment goals in a large number of women with","confidence":1,"confidence_rate":1},{"cnt":[[146,1753],[1944,1753],[1944,1798],[146,1798]],"region":{"top_left_x":146,"top_left_y":1753,"width":1799,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e269627f4d24fbd92ac969ab77df907","type":"text","conversion_output":true,"text":"MUI undergoing MUS surgery and assess whether or not those goals are achieved. While goal attainment","text_display":" MUI undergoing MUS surgery and assess whether or not those goals are achieved. While goal attainment","confidence":1,"confidence_rate":1},{"cnt":[[146,1796],[1869,1796],[1869,1841],[146,1841]],"region":{"top_left_x":146,"top_left_y":1796,"width":1724,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed9b5254e23f49298ec76fc5cd39f0f4","type":"text","conversion_output":true,"text":"scaling is an established method of assessing individual goals, until recently, a standardized and valid","text_display":" scaling is an established method of assessing individual goals, until recently, a standardized and valid","confidence":1,"confidence_rate":1},{"cnt":[[146,1841],[1966,1841],[1966,1884],[146,1884]],"region":{"top_left_x":146,"top_left_y":1841,"width":1820,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d9a29b057344585841ac44ec8b37a76","type":"text","conversion_output":true,"text":"measure of assessing goals was not available. The SAGA questionnaire has been validated among women","text_display":" measure of assessing goals was not available. The SAGA questionnaire has been validated among women","confidence":1,"confidence_rate":1},{"cnt":[[146,1884],[1931,1884],[1931,1927],[146,1927]],"region":{"top_left_x":146,"top_left_y":1884,"width":1786,"height":44},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8e8ef9d089f4e42a492dd19f6bb19ad","type":"text","conversion_output":true,"text":"with lower urinary tract symptoms and fills that void.(Brubaker, 2013) SAGA consists of nine standardized","text_display":" with lower urinary tract symptoms and fills that void.(Brubaker, 2013) SAGA consists of nine standardized","confidence":1,"confidence_rate":1},{"cnt":[[146,1929],[1949,1929],[1949,1974],[146,1974]],"region":{"top_left_x":146,"top_left_y":1929,"width":1803,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"846af6b1cf2b468887037f8f23c47252","type":"text","conversion_output":true,"text":"goals regarding urinary symptoms, and asks women to rate the importance of these standardized goals on","text_display":" goals regarding urinary symptoms, and asks women to rate the importance of these standardized goals on","confidence":1,"confidence_rate":1},{"cnt":[[146,1972],[1910,1972],[1910,2017],[146,2017]],"region":{"top_left_x":146,"top_left_y":1972,"width":1764,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fe0dd7812504a5a979d01df8b9e5098","type":"text","conversion_output":true,"text":"a scale from 0 (not applicable) to 5 (very important goal). In addition to these common goals, women are","text_display":" a scale from 0 (not applicable) to 5 (very important goal). In addition to these common goals, women are","confidence":1,"confidence_rate":1},{"cnt":[[146,2015],[1854,2015],[1854,2060],[146,2060]],"region":{"top_left_x":146,"top_left_y":2015,"width":1709,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95a0031132f24f058457ba6c299ee19a","type":"text","conversion_output":true,"text":"asked to record up to five of their individualized goals and rank them in a similar fashion. At follow-up","text_display":" asked to record up to five of their individualized goals and rank them in a similar fashion. At follow-up","confidence":1,"confidence_rate":1},{"cnt":[[146,2058],[1901,2058],[1901,2103],[146,2103]],"region":{"top_left_x":146,"top_left_y":2058,"width":1756,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e72998ff1efd44708d3e9c9fb239e5e0","type":"text","conversion_output":true,"text":"following treatment, women are asked to rate whether or not they achieved their goals on a scale from 1","text_display":" following treatment, women are asked to rate whether or not they achieved their goals on a scale from 1","confidence":1,"confidence_rate":1},{"cnt":[[146,2103],[1837,2103],[1837,2151],[146,2151]],"region":{"top_left_x":146,"top_left_y":2103,"width":1691,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f95745cfc97d4918b5b2d61398bc343b","type":"text","conversion_output":true,"text":"(did not achieve goal) to 5 (greatly exceeded goal). Importantly, the common goal list of 9 items was","text_display":" (did not achieve goal) to 5 (greatly exceeded goal). Importantly, the common goal list of 9 items was","confidence":1,"confidence_rate":1},{"cnt":[[146,2148],[1962,2148],[1962,2194],[146,2194]],"region":{"top_left_x":146,"top_left_y":2148,"width":1816,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fba2ab9fc7cd407397272f0ba1d6a67a","type":"text","conversion_output":true,"text":"generated from patient and expert interviews, and has undergone validation both within the US and abroad.","text_display":" generated from patient and expert interviews, and has undergone validation both within the US and abroad.","confidence":1,"confidence_rate":1},{"cnt":[[146,2191],[1940,2191],[1940,2237],[146,2237]],"region":{"top_left_x":146,"top_left_y":2191,"width":1795,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eee39da4056a42fa814ee6c64d4f4e07","type":"text","conversion_output":true,"text":"Adequate face, concurrent, known-groups, and convergent validity and item distribution validity have been","text_display":" Adequate face, concurrent, known-groups, and convergent validity and item distribution validity have been","confidence":1,"confidence_rate":1},{"cnt":[[146,2234],[1910,2234],[1910,2279],[146,2279]],"region":{"top_left_x":146,"top_left_y":2234,"width":1764,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9972a651746402997491c5d195e1d4f","type":"text","conversion_output":true,"text":"determined in a pilot study of 104 subjects and re-evaluated on an international basis in an additional 29","text_display":" determined in a pilot study of 104 subjects and re-evaluated on an international basis in an additional 29","confidence":1,"confidence_rate":1},{"cnt":[[146,2277],[1906,2277],[1906,2322],[146,2322]],"region":{"top_left_x":146,"top_left_y":2277,"width":1760,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1232c20db4d64a14845ab4fd4ae117f7","type":"text","conversion_output":true,"text":"subjects. Reliability and internal consistency testing was not performed because goals were assumed to","text_display":" subjects. Reliability and internal consistency testing was not performed because goals were assumed to","confidence":1,"confidence_rate":1},{"cnt":[[146,2325],[1884,2325],[1884,2368],[146,2368]],"region":{"top_left_x":146,"top_left_y":2324,"width":1739,"height":44},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"265168b51c8641f0bdea5e1fb2873bf3","type":"text","conversion_output":true,"text":"vary between individuals. This proposal is innovative, in our opinion, because it will assess goal setting","text_display":" vary between individuals. This proposal is innovative, in our opinion, because it will assess goal setting","confidence":1,"confidence_rate":1},{"cnt":[[146,2368],[1910,2368],[1910,2413],[146,2413]],"region":{"top_left_x":146,"top_left_y":2367,"width":1764,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b36c0b829b954abba866bfa48976163f","type":"text","conversion_output":true,"text":"using a newly validated questionnaire in a large group of women with MUI, a common condition which is","text_display":" using a newly validated questionnaire in a large group of women with MUI, a common condition which is","confidence":1,"confidence_rate":1},{"cnt":[[146,2411],[1974,2411],[1974,2456],[146,2456]],"region":{"top_left_x":146,"top_left_y":2410,"width":1829,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6b0949294c64ddea574e16115efaeec","type":"text","conversion_output":true,"text":"difficult for patients to understand and for providers to explain, and will determine whether goal attainment is","text_display":" difficult for patients to understand and for providers to explain, and will determine whether goal attainment is","confidence":1,"confidence_rate":1},{"cnt":[[146,2454],[1936,2454],[1936,2499],[146,2499]],"region":{"top_left_x":146,"top_left_y":2453,"width":1790,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64290d1015dc42b0b12e3bdea107b147","type":"text","conversion_output":true,"text":"linked to patient global impression of improvement both in the short and long term. Finally, this innovative","text_display":" linked to patient global impression of improvement both in the short and long term. 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This ultimately may inform","text_display":"\nscience of a comparative effectiveness trial to individual patients seeking care. This ultimately may inform","confidence":1,"confidence_rate":1},{"cnt":[[146,305],[1360,305],[1360,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1214,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"714b7af12e7947b1a4691545f77d7a21","type":"text","conversion_output":true,"text":"community dwelling women's decisions to pursue or not to pursue care.","text_display":" community dwelling women's decisions to pursue or not to pursue care.","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[329,391],[329,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":183,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63c292c1ad88484d9c5763dd410a5c5a","type":"section_header","conversion_output":false,"children_ids":["22833148e57243fab41149ef5daff5a4"],"text":"","text_display":""},{"cnt":[[146,391],[324,391],[324,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":179,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22833148e57243fab41149ef5daff5a4","type":"text","conversion_output":true,"parent_id":"63c292c1ad88484d9c5763dd410a5c5a","text":"Approach:","text_display":"\n\n\\section*{Approach:}","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[146,436],[1972,436],[1972,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1827,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ca430ee6aac4be5816e9c1666899d00","type":"text","conversion_output":true,"text":"Aim 1: To describe patient reported goals and ranking of goals among women consenting for ESTEEM. We","text_display":"\n\nAim 1: To describe patient reported goals and ranking of goals among women consenting for ESTEEM. We","confidence":1,"confidence_rate":1},{"cnt":[[146,481],[1893,481],[1893,522],[146,522]],"region":{"top_left_x":146,"top_left_y":481,"width":1747,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7be477b31e24bf99dfd238df9bbef48","type":"text","conversion_output":true,"text":"hypothesize that women's goals vary and are not currently captured by standard symptom severity and","text_display":" hypothesize that women's goals vary and are not currently captured by standard symptom severity and","confidence":1,"confidence_rate":1},{"cnt":[[150,524],[419,524],[419,561],[150,561]],"region":{"top_left_x":150,"top_left_y":524,"width":269,"height":37},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44968b1aa39747809b4fb82462c98444","type":"text","conversion_output":true,"text":"QOL measures.","text_display":" QOL measures.","confidence":1,"confidence_rate":1},{"cnt":[[146,610],[1927,610],[1927,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1782,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fbf56c023644f5ebd7f734dc4a34172","type":"text","conversion_output":true,"text":"Introduction: Assessment of individualized patient goals offers a unique perspective of expectations and","text_display":"\n\nIntroduction: Assessment of individualized patient goals offers a unique perspective of expectations and","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[1949,655],[1949,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1803,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fb1956d3957485885c35b67792b0901","type":"text","conversion_output":true,"text":"goals with treatment that current PROs do not capture. The objective of this aim is to administer the SAGA","text_display":" goals with treatment that current PROs do not capture. The objective of this aim is to administer the SAGA","confidence":1,"confidence_rate":1},{"cnt":[[146,700],[1934,700],[1934,741],[146,741]],"region":{"top_left_x":146,"top_left_y":700,"width":1788,"height":42},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d515bd81b7c1456a9c7bd9a682144a4f","type":"text","conversion_output":true,"text":"questionnaire at women's baseline visit in ESTEEM and to describe their ranking of the nine standardized","text_display":" questionnaire at women's baseline visit in ESTEEM and to describe their ranking of the nine standardized","confidence":1,"confidence_rate":1},{"cnt":[[146,743],[1953,743],[1953,786],[146,786]],"region":{"top_left_x":146,"top_left_y":743,"width":1807,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7c689bf135247cb9e153ced1bf9ea9b","type":"text","conversion_output":true,"text":"questions in SAGA. In addition, women will be asked to list up to five individualized goals for treatment and","text_display":" questions in SAGA. In addition, women will be asked to list up to five individualized goals for treatment and","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[146,786],[1931,786],[1931,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1786,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"870fe615d1e94f94bdacd807c6bfca4e","type":"text","conversion_output":true,"text":"also rank their importance. Our working hypothesis is that the importance of the 9 common goals will vary","text_display":" also rank their importance. Our working hypothesis is that the importance of the 9 common goals will vary","confidence":1,"confidence_rate":1},{"cnt":[[146,831],[1929,831],[1929,874],[146,874]],"region":{"top_left_x":146,"top_left_y":831,"width":1784,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"061088f088b34f63b46370b4b2a6eb2e","type":"text","conversion_output":true,"text":"between individuals. In addition we hypothesize that women will list a variety of individual goals which are","text_display":" between individuals. In addition we hypothesize that women will list a variety of individual goals which are","confidence":1,"confidence_rate":1},{"cnt":[[146,877],[1899,877],[1899,917],[146,917]],"region":{"top_left_x":146,"top_left_y":876,"width":1754,"height":42},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60ba660d0fc74a7fa289d4cc6d1085c6","type":"text","conversion_output":true,"text":"not presently represented by symptom severity and quality of life measures. We will achieve this aim by","text_display":" not presently represented by symptom severity and quality of life measures. We will achieve this aim by","confidence":1,"confidence_rate":1},{"cnt":[[146,920],[1944,920],[1944,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1799,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39fe94ade90a4713bb9ea296f6c6f589","type":"text","conversion_output":true,"text":"administering the SAGA questionnaire at baseline in women recruited to ESTEEM. Our expectation is that","text_display":" administering the SAGA questionnaire at baseline in women recruited to ESTEEM. Our expectation is that","confidence":1,"confidence_rate":1},{"cnt":[[146,962],[1878,962],[1878,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":962,"width":1732,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f52d67cd337482893b8619861d0c0d5","type":"text","conversion_output":true,"text":"the description of baseline goals of women recruited to ESTEEM will offer insight into what women are","text_display":" the description of baseline goals of women recruited to ESTEEM will offer insight into what women are","confidence":1,"confidence_rate":1},{"cnt":[[146,1008],[763,1008],[763,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1007,"width":617,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02f89743b3bf4417af3f3e158301b27c","type":"text","conversion_output":true,"text":"seeking with treatment for their MUI.","text_display":" seeking with treatment for their MUI.","confidence":1,"confidence_rate":1},{"cnt":[[146,1096],[1931,1096],[1931,1137],[146,1137]],"region":{"top_left_x":146,"top_left_y":1095,"width":1786,"height":42},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d804127f2ac84f5194c23b9e53d2332e","type":"text","conversion_output":true,"text":"Methods: Women will be administered the baseline set of nine pre-specified goals as well as be asked to","text_display":"\n\nMethods: Women will be administered the baseline set of nine pre-specified goals as well as be asked to","confidence":1,"confidence_rate":1},{"cnt":[[146,1139],[1968,1139],[1968,1182],[146,1182]],"region":{"top_left_x":146,"top_left_y":1138,"width":1822,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd3c248796944d71a15427aa45c05d56","type":"text","conversion_output":true,"text":"list up to 5 individual goals for their therapy. Goals will be ranked on a 6 point scale from 0-Not applicable to","text_display":" list up to 5 individual goals for their therapy. Goals will be ranked on a 6 point scale from 0-Not applicable to","confidence":0.97705078125,"confidence_rate":0.9998127864655472},{"cnt":[[146,1182],[1957,1182],[1957,1227],[146,1227]],"region":{"top_left_x":146,"top_left_y":1181,"width":1812,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b7d62cafcaf4544bb046c7ee570363f","type":"text","conversion_output":true,"text":"5 - very important goal. In the original validation study of the SAGA, women randomly completed either the","text_display":" 5 - very important goal. In the original validation study of the SAGA, women randomly completed either the","confidence":0.611328125,"confidence_rate":0.9955361614527813},{"cnt":[[146,1225],[1880,1225],[1880,1270],[146,1270]],"region":{"top_left_x":146,"top_left_y":1224,"width":1734,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5778ad5f7568478fbf3d150778ca705e","type":"text","conversion_output":true,"text":"pre-specified or self-specified goals first. No order effects were noted in the numbers of goals listed or","text_display":" pre-specified or self-specified goals first. No order effects were noted in the numbers of goals listed or","confidence":1,"confidence_rate":1},{"cnt":[[146,1268],[982,1268],[982,1315],[146,1315]],"region":{"top_left_x":146,"top_left_y":1267,"width":836,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"385365d28a0f49ae89ee07755c19702f","type":"text","conversion_output":true,"text":"ranking of nine pre-specified goals. For this study","text_display":" ranking of nine pre-specified goals. For this study","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[146,1315],[849,1315],[849,1360],[146,1360]],"region":{"top_left_x":146,"top_left_y":1314,"width":703,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdd095bf2f094c068a0de5d8faff8c25","type":"text","conversion_output":true,"text":"will complete the nine pre-specified goals","text_display":" will complete the nine pre-specified goals","confidence":1,"confidence_rate":1},{"cnt":[[146,1358],[816,1358],[816,1403],[146,1403]],"region":{"top_left_x":146,"top_left_y":1357,"width":671,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43799b46c90d4094bdf76572233e31c7","type":"text","conversion_output":true,"text":"followed by listing their individual goals.","text_display":" followed by listing their individual goals.","confidence":1,"confidence_rate":1},{"cnt":[[146,1401],[879,1401],[879,1446],[146,1446]],"region":{"top_left_x":146,"top_left_y":1400,"width":733,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bc261579df5442b946eb86f015494b1","type":"text","conversion_output":true,"text":"Individualized goals will be transcribed and","text_display":" Individualized goals will be transcribed and","confidence":1,"confidence_rate":1},{"cnt":[[146,1446],[930,1446],[930,1489],[146,1489]],"region":{"top_left_x":146,"top_left_y":1445,"width":785,"height":44},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6992f8d10e06496480e63f883a702e64","type":"text","conversion_output":true,"text":"entered into the patient database; these goals","text_display":" entered into the patient database; these goals","confidence":1,"confidence_rate":1},{"cnt":[[146,1491],[917,1491],[917,1532],[146,1532]],"region":{"top_left_x":146,"top_left_y":1491,"width":772,"height":41},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92448f1addcf475ba2dbd90cddd7c644","type":"text","conversion_output":true,"text":"will then be presented to the patient in follow-","text_display":" will then be presented to the patient in follow","confidence":1,"confidence_rate":1},{"cnt":[[146,1534],[939,1534],[939,1579],[146,1579]],"region":{"top_left_x":146,"top_left_y":1533,"width":793,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fa13c535ffb44268a740a2f6596afb5","type":"text","conversion_output":true,"text":"up assessment of goal achievement in Aim \\#2.","text_display":"up assessment of goal achievement in Aim \\#2.","confidence":1,"confidence_rate":1},{"cnt":[[146,1577],[748,1577],[748,1622],[146,1622]],"region":{"top_left_x":146,"top_left_y":1576,"width":602,"height":47},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e615f3bf4b5f4bf7845359dc7583d676","type":"text","conversion_output":true,"text":"Table 1 is the SAGA questionnaire.","text_display":" Table 1 is the SAGA questionnaire.","confidence":1,"confidence_rate":1},{"cnt":[[146,1663],[887,1663],[887,1708],[146,1708]],"region":{"top_left_x":146,"top_left_y":1662,"width":742,"height":47},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"188af242dc67454991fadf56d26c6a30","type":"text","conversion_output":true,"text":"Aim \\#1 is descriptive in nature therefore the","text_display":"\n\nAim \\#1 is descriptive in nature therefore the","confidence":1,"confidence_rate":1},{"cnt":[[146,1710],[892,1710],[892,1755],[146,1755]],"region":{"top_left_x":146,"top_left_y":1710,"width":746,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2759b928b8084fcb8b06b6e933812341","type":"text","conversion_output":true,"text":"analyses are qualitative versus quantitative.","text_display":" analyses are qualitative versus quantitative.","confidence":1,"confidence_rate":1},{"cnt":[[146,1753],[932,1753],[932,1798],[146,1798]],"region":{"top_left_x":146,"top_left_y":1753,"width":787,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c1fd8cc72f048dca0462360ad10d060","type":"text","conversion_output":true,"text":"For self-selected goals, goals will be classified","text_display":" For self-selected goals, goals will be classified","confidence":1,"confidence_rate":1},{"cnt":[[146,1796],[879,1796],[879,1841],[146,1841]],"region":{"top_left_x":146,"top_left_y":1796,"width":733,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dfbae6ca1ca4e2c8c1328a5a66662d3","type":"text","conversion_output":true,"text":"by the study working group into categories.","text_display":" by the study working group into categories.","confidence":1,"confidence_rate":1},{"cnt":[[146,1841],[862,1841],[862,1884],[146,1884]],"region":{"top_left_x":146,"top_left_y":1841,"width":716,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18fd8b9d0ec44176b583592decd91990","type":"text","conversion_output":true,"text":"The working group will review the goals in","text_display":" The working group will review the goals in","confidence":1,"confidence_rate":1},{"cnt":[[146,1886],[862,1886],[862,1929],[146,1929]],"region":{"top_left_x":146,"top_left_y":1886,"width":716,"height":44},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"934d7ab455dd4a04b1f30b46085c28f3","type":"text","conversion_output":true,"text":"order to generate categories; goals will be","text_display":" order to generate categories; goals will be","confidence":1,"confidence_rate":1},{"cnt":[[146,1929],[814,1929],[814,1974],[146,1974]],"region":{"top_left_x":146,"top_left_y":1929,"width":669,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a60e8e1a0ba481a95a86d13fde6977f","type":"text","conversion_output":true,"text":"categorized and then compared across","text_display":" categorized and then compared across","confidence":1,"confidence_rate":1},{"cnt":[[146,1972],[862,1972],[862,2017],[146,2017]],"region":{"top_left_x":146,"top_left_y":1972,"width":716,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"098d213bbf72464e99890d866acce666","type":"text","conversion_output":true,"text":"individual categorization. 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Once all votes have been counted, the candidate with the most points is","text_display":" candidate is ranked by each voter. Once all votes have been counted, the candidate with the most points is","confidence":1,"confidence_rate":1},{"cnt":[[146,348],[1953,348],[1953,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1807,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4166497137545c2931fda239e82cf67","type":"text","conversion_output":true,"text":"the winner. In our analysis, a modified Borda preferential ballot consists of candidates (here, the list of goal","text_display":" the winner. In our analysis, a modified Borda preferential ballot consists of candidates (here, the list of goal","confidence":1,"confidence_rate":1},{"cnt":[[146,391],[1936,391],[1936,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1790,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b6afa0d6b614d0c82d6968b17b499d9","type":"text","conversion_output":true,"text":"subdomains) and a ballot for each participant, in which a rank of 1 is assigned for the participant's highest","text_display":" subdomains) and a ballot for each participant, in which a rank of 1 is assigned for the participant's highest","confidence":1,"confidence_rate":1},{"cnt":[[146,436],[1934,436],[1934,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1788,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53ba4bc80049451884357f6893aa4c25","type":"text","conversion_output":true,"text":"ranked goal, a rank of 2 for their second highest ranked goal, and so on. If a participant doesn't rank all of","text_display":" ranked goal, a rank of 2 for their second highest ranked goal, and so on. If a participant doesn't rank all of","confidence":1,"confidence_rate":1},{"cnt":[[146,481],[1972,481],[1972,522],[146,522]],"region":{"top_left_x":146,"top_left_y":481,"width":1827,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9e97561c0b54fcbad181c216ae90227","type":"text","conversion_output":true,"text":"the candidates (goal subdomains), then the mid-rank of the un-used ranks are assigned - this assures each","text_display":" the candidates (goal subdomains), then the mid-rank of the un-used ranks are assigned - this assures each","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[146,524],[1936,524],[1936,569],[146,569]],"region":{"top_left_x":146,"top_left_y":524,"width":1790,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52ce6e13d65648af91169ea0ab4dce19","type":"text","conversion_output":true,"text":"ballot receives equal weight in the ballot count. The derivation of mid-rank was calculated by summing the","text_display":" ballot receives equal weight in the ballot count. The derivation of mid-rank was calculated by summing the","confidence":1,"confidence_rate":1},{"cnt":[[146,567],[1893,567],[1893,610],[146,610]],"region":{"top_left_x":146,"top_left_y":567,"width":1747,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08e81fec9c5d4eb7a47b86d77aa5029a","type":"text","conversion_output":true,"text":"remainder of the ranks divided by number of left over ranks. The first winner is based in lowest average","text_display":" remainder of the ranks divided by number of left over ranks. The first winner is based in lowest average","confidence":1,"confidence_rate":1},{"cnt":[[146,610],[1953,610],[1953,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1807,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbeed9b62d7b428b983a30f72bda5dd6","type":"text","conversion_output":true,"text":"rank across all ballots, the second winner is based in second lowest average rank, and so on. The analysis","text_display":" rank across all ballots, the second winner is based in second lowest average rank, and so on. The analysis","confidence":1,"confidence_rate":1},{"cnt":[[146,655],[1871,655],[1871,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1726,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c90baec71d554a14bd6319f4ce769911","type":"text","conversion_output":true,"text":"of ballots can be done simply by computing the average rank for each goal category across all ballots.","text_display":" of ballots can be done simply by computing the average rank for each goal category across all ballots.","confidence":1,"confidence_rate":1},{"cnt":[[148,743],[1863,743],[1863,786],[148,786]],"region":{"top_left_x":148,"top_left_y":743,"width":1715,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f08f6a6995624c91be1a73d38a13341d","type":"text","conversion_output":true,"text":"Since this aim is qualitative in nature a formal power analysis was not computed; given the number of","text_display":"\n\nSince this aim is qualitative in nature a formal power analysis was not computed; given the number of","confidence":1,"confidence_rate":1},{"cnt":[[146,786],[1927,786],[1927,831],[146,831]],"region":{"top_left_x":146,"top_left_y":786,"width":1782,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff40b12eca8448b19a2249bb89a64b64","type":"text","conversion_output":true,"text":"women who will be recruited to ESTEEM, we should have more than enough subjects to reach saturation","text_display":" women who will be recruited to ESTEEM, we should have more than enough subjects to reach saturation","confidence":1,"confidence_rate":1},{"cnt":[[146,831],[1532,831],[1532,874],[146,874]],"region":{"top_left_x":146,"top_left_y":831,"width":1386,"height":44},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ac37633b5cc474cbbdeabcf14daedf9","type":"text","conversion_output":true,"text":"on goal categories and to evaluated even small difference between goal rankings.","text_display":" on goal categories and to evaluated even small difference between goal rankings.","confidence":1,"confidence_rate":1},{"cnt":[[146,920],[1970,920],[1970,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1825,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25d2f40206df46879c16293ec544d980","type":"text","conversion_output":true,"text":"Potential Problems and Solutions: It may be that women have difficulty in generating individualized goals,","text_display":"\n\nPotential Problems and Solutions: It may be that women have difficulty in generating individualized goals,","confidence":1,"confidence_rate":1},{"cnt":[[146,965],[1944,965],[1944,1008],[146,1008]],"region":{"top_left_x":146,"top_left_y":964,"width":1799,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56fafc46a93846ccbd983e8d3b758dc0","type":"text","conversion_output":true,"text":"although prior research has documented that women, on average, do not have difficulty generating up to 4","text_display":" although prior research has documented that women, on average, do not have difficulty generating up to 4","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[146,1008],[1940,1008],[1940,1051],[146,1051]],"region":{"top_left_x":146,"top_left_y":1007,"width":1795,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0da955434fa247b59797d93ae60ef138","type":"text","conversion_output":true,"text":"goals in prior studies. If women have difficulty generating goals, they will be prompted by the coordinators","text_display":" goals in prior studies. If women have difficulty generating goals, they will be prompted by the coordinators","confidence":1,"confidence_rate":1},{"cnt":[[146,1053],[1966,1053],[1966,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1052,"width":1820,"height":42},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26611307184a47d598983f8236f31737","type":"text","conversion_output":true,"text":"to list what they wish to achieve with their treatment; this will be done without prompting for specific goals to","text_display":" to list what they wish to achieve with their treatment; this will be done without prompting for specific goals to","confidence":1,"confidence_rate":1},{"cnt":[[146,1096],[333,1096],[333,1132],[146,1132]],"region":{"top_left_x":146,"top_left_y":1095,"width":188,"height":38},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b2fa094271647c79cef361a7971b4e3","type":"text","conversion_output":true,"text":"avoid bias.","text_display":" avoid bias.","confidence":1,"confidence_rate":1},{"cnt":[[208,1182],[1970,1182],[1970,1227],[208,1227]],"region":{"top_left_x":208,"top_left_y":1181,"width":1763,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04127fe0e8fc40308085570d6ae327b5","type":"text","conversion_output":true,"text":"Aim 2: To determine whether or not women achieve self-reported goals following treatment for MUI. We","text_display":"\n\nAim 2: To determine whether or not women achieve self-reported goals following treatment for MUI. We","confidence":1,"confidence_rate":1},{"cnt":[[146,1227],[1921,1227],[1921,1270],[146,1270]],"region":{"top_left_x":146,"top_left_y":1226,"width":1775,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22cbcabbe7a04825877637bd6d554670","type":"text","conversion_output":true,"text":"hypothesize that women who report and rank specific continence related goals are more likely to achieve","text_display":" hypothesize that women who report and rank specific continence related goals are more likely to achieve","confidence":1,"confidence_rate":1},{"cnt":[[146,1268],[1951,1268],[1951,1313],[146,1313]],"region":{"top_left_x":146,"top_left_y":1267,"width":1805,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f2db9f590f34dc09d3c625c3f789555","type":"text","conversion_output":true,"text":"those goals than goals related to general health and specific activities and that achievement of these goals","text_display":" those goals than goals related to general health and specific activities and that achievement of these goals","confidence":1,"confidence_rate":1},{"cnt":[[148,1315],[1949,1315],[1949,1358],[148,1358]],"region":{"top_left_x":148,"top_left_y":1314,"width":1801,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d87c9f53e0143f2a2ad1f20a4e69ada","type":"text","conversion_output":true,"text":"will be related to patient's PGI-I scores. In addition, we hypothesize that women whose goals are achieved","text_display":" will be related to patient's PGI-I scores. In addition, we hypothesize that women whose goals are achieved","confidence":1,"confidence_rate":1},{"cnt":[[148,1358],[1949,1358],[1949,1403],[148,1403]],"region":{"top_left_x":148,"top_left_y":1357,"width":1801,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"614abc8b06914744810f9033410e31f6","type":"text","conversion_output":true,"text":"will report better global improvement in continence and quality of life than women who do not achieve their","text_display":" will report better global improvement in continence and quality of life than women who do not achieve their","confidence":1,"confidence_rate":1},{"cnt":[[146,1401],[251,1401],[251,1446],[146,1446]],"region":{"top_left_x":146,"top_left_y":1400,"width":106,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3925d36d99d84880b344f2d8391dc40d","type":"text","conversion_output":true,"text":"goals.","text_display":" goals.","confidence":1,"confidence_rate":1},{"cnt":[[157,1491],[1824,1491],[1824,1534],[157,1534]],"region":{"top_left_x":156,"top_left_y":1491,"width":1669,"height":43},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3de8f0b6f71a4aec99f3c7ee62278d85","type":"text","conversion_output":true,"text":"Introduction: Achievement of patient goals offers a unique perspective of patient's assessment of","text_display":"\n\nIntroduction: Achievement of patient goals offers a unique perspective of patient's assessment of","confidence":1,"confidence_rate":1},{"cnt":[[146,1534],[1869,1534],[1869,1579],[146,1579]],"region":{"top_left_x":146,"top_left_y":1533,"width":1724,"height":47},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"388f536cfe004ad486dcc1c08956e9d1","type":"text","conversion_output":true,"text":"outcome of treatment. The objective of this aim is to administer the SAGA follow-up goal achievement","text_display":" outcome of treatment. The objective of this aim is to administer the SAGA follow-up goal achievement","confidence":1,"confidence_rate":1},{"cnt":[[146,1577],[1921,1577],[1921,1622],[146,1622]],"region":{"top_left_x":146,"top_left_y":1576,"width":1775,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8217f3e475604941a4f92eb415b8a584","type":"text","conversion_output":true,"text":"questionnaire at women's follow-up visits in ESTEEM at 6 and 2 months. We will describe women's goal","text_display":" questionnaire at women's follow-up visits in ESTEEM at 6 and 2 months. We will describe women's goal","confidence":1,"confidence_rate":1},{"cnt":[[146,1622],[1841,1622],[1841,1665],[146,1665]],"region":{"top_left_x":146,"top_left_y":1622,"width":1696,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f2d5660196945788f9c23a6d47d377b","type":"text","conversion_output":true,"text":"achievement and compare which goal categories are more likely to be achieved. In addition, we will","text_display":" achievement and compare which goal categories are more likely to be achieved. In addition, we will","confidence":1,"confidence_rate":1},{"cnt":[[146,1663],[1850,1663],[1850,1708],[146,1708]],"region":{"top_left_x":146,"top_left_y":1662,"width":1704,"height":47},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f8c9e57526b4267951b8123af646aa5","type":"text","conversion_output":true,"text":"correlate goal achievement with PGI-I scores to further evaluate which goals are best correlated with","text_display":" correlate goal achievement with PGI-I scores to further evaluate which goals are best correlated with","confidence":1,"confidence_rate":1},{"cnt":[[146,1710],[1893,1710],[1893,1755],[146,1755]],"region":{"top_left_x":146,"top_left_y":1710,"width":1747,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00a970267a0147999fa1e9373df6ea0c","type":"text","conversion_output":true,"text":"patient's global impression of improvement. Finally, we will observe whether goal achievement is stable","text_display":" patient's global impression of improvement. Finally, we will observe whether goal achievement is stable","confidence":1,"confidence_rate":1},{"cnt":[[146,1753],[1944,1753],[1944,1798],[146,1798]],"region":{"top_left_x":146,"top_left_y":1753,"width":1799,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c75b4dc8fa634c1d92a9e7a914562be5","type":"text","conversion_output":true,"text":"between 6 and 12 months by comparing goals achievement at the two timepoints. Our working hypothesis","text_display":" between 6 and 12 months by comparing goals achievement at the two timepoints. Our working hypothesis","confidence":0.99853515625,"confidence_rate":0.9999867936215969},{"cnt":[[146,1796],[1884,1796],[1884,1841],[146,1841]],"region":{"top_left_x":146,"top_left_y":1796,"width":1739,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5540dbe862174cbeae3d7cfa6eb03219","type":"text","conversion_output":true,"text":"is that goal achievement varies between individuals and that women who rank continence goals will be","text_display":" is that goal achievement varies between individuals and that women who rank continence goals will be","confidence":1,"confidence_rate":1},{"cnt":[[146,1841],[1899,1841],[1899,1884],[146,1884]],"region":{"top_left_x":146,"top_left_y":1841,"width":1754,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56248b010440463a88dce1d9bf5ab88c","type":"text","conversion_output":true,"text":"more likely to achieve those goals than goals not related to continence. In addition we hypothesize that","text_display":" more likely to achieve those goals than goals not related to continence. In addition we hypothesize that","confidence":1,"confidence_rate":1},{"cnt":[[146,1886],[1927,1886],[1927,1927],[146,1927]],"region":{"top_left_x":146,"top_left_y":1886,"width":1782,"height":42},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdaa328e04d543bf86c59cea5731a475","type":"text","conversion_output":true,"text":"goal achievement changes over time and that more women will achieve goals at 6 months than do at one","text_display":" goal achievement changes over time and that more women will achieve goals at 6 months than do at one","confidence":1,"confidence_rate":1},{"cnt":[[146,1929],[1923,1929],[1923,1972],[146,1972]],"region":{"top_left_x":146,"top_left_y":1929,"width":1777,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"236a0744d27d40bbab73347e5e3d6dca","type":"text","conversion_output":true,"text":"year. Finally, we hypothesize that goal achievement will be significantly correlated with PGI-I scores. We","text_display":" year. Finally, we hypothesize that goal achievement will be significantly correlated with PGI-I scores. We","confidence":1,"confidence_rate":1},{"cnt":[[146,1972],[1846,1972],[1846,2017],[146,2017]],"region":{"top_left_x":146,"top_left_y":1972,"width":1700,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b9e3ed96c2144f5bb4d4e2bc40cc2ad","type":"text","conversion_output":true,"text":"will achieve this aim by administering the SAGA follow-up questionnaire at 6 months and one year in","text_display":" will achieve this aim by administering the SAGA follow-up questionnaire at 6 months and one year in","confidence":1,"confidence_rate":1},{"cnt":[[146,2017],[1867,2017],[1867,2060],[146,2060]],"region":{"top_left_x":146,"top_left_y":2017,"width":1721,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67679f3636b84f0b930318b9af9bb2b4","type":"text","conversion_output":true,"text":"women recruited to ESTEEM. Our expectation is that goal achievement varies over time and between","text_display":" women recruited to ESTEEM. Our expectation is that goal achievement varies over time and between","confidence":1,"confidence_rate":1},{"cnt":[[146,2058],[1253,2058],[1253,2103],[146,2103]],"region":{"top_left_x":146,"top_left_y":2058,"width":1107,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d904f83ad1174252a93bfc1acd7cd734","type":"text","conversion_output":true,"text":"individuals based on baseline goal setting and treatment efficacy.","text_display":" individuals based on baseline goal setting and treatment efficacy.","confidence":1,"confidence_rate":1},{"cnt":[[148,2148],[1957,2148],[1957,2194],[148,2194]],"region":{"top_left_x":148,"top_left_y":2148,"width":1810,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c515cf0681fb449383bb6e478de49edf","type":"text","conversion_output":true,"text":"Methods: Women will be administered the follow-up SAGA questionnaire at 6 months and one year follow-","text_display":"\n\nMethods: Women will be administered the follow-up SAGA questionnaire at 6 months and one year follow","confidence":1,"confidence_rate":1},{"cnt":[[148,2191],[1906,2191],[1906,2237],[148,2237]],"region":{"top_left_x":148,"top_left_y":2191,"width":1758,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca43f07ce4f84294b2c5ac450b0ee0f1","type":"text","conversion_output":true,"text":"up in the ESTEEM trial. The follow-up questionnaire is similar to the baseline questionnaire in that it still","text_display":"up in the ESTEEM trial. The follow-up questionnaire is similar to the baseline questionnaire in that it still","confidence":1,"confidence_rate":1},{"cnt":[[146,2239],[1927,2239],[1927,2279],[146,2279]],"region":{"top_left_x":146,"top_left_y":2238,"width":1782,"height":42},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ef63a6978354735a4b3155f6d099521","type":"text","conversion_output":true,"text":"contains the 9 pre-specified goals and a list of the patient's self-determined goals established at baseline.","text_display":" contains the 9 pre-specified goals and a list of the patient's self-determined goals established at baseline.","confidence":1,"confidence_rate":1},{"cnt":[[146,2279],[1846,2279],[1846,2322],[146,2322]],"region":{"top_left_x":146,"top_left_y":2279,"width":1700,"height":44},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0b5438f11554711bdf706871399195a","type":"text","conversion_output":true,"text":"The response categories for follow-up are 1 (did not achieve goal) to 5 (greatly exceeded goal). The","text_display":" The response categories for follow-up are 1 (did not achieve goal) to 5 (greatly exceeded goal). The","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[146,2325],[1953,2325],[1953,2368],[146,2368]],"region":{"top_left_x":146,"top_left_y":2324,"width":1807,"height":44},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23a88ba9b80d4a29ae86abafbc026023","type":"text","conversion_output":true,"text":"number of goals for each patient will vary as women may report less that 5 self-determined goals, and they","text_display":" number of goals for each patient will vary as women may report less that 5 self-determined goals, and they","confidence":1,"confidence_rate":1},{"cnt":[[146,2368],[1601,2368],[1601,2413],[146,2413]],"region":{"top_left_x":146,"top_left_y":2367,"width":1455,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"446d15ac589b4ac68b78535250342702","type":"text","conversion_output":true,"text":"may have ranked some of the nine pre-specified goals as \"not-applicable\" at baseline.","text_display":" may have ranked some of the nine pre-specified goals as \"not-applicable\" at baseline.","confidence":1,"confidence_rate":1},{"cnt":[[146,2458],[1901,2458],[1901,2499],[146,2499]],"region":{"top_left_x":146,"top_left_y":2457,"width":1756,"height":42},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89b3ee4ab99648d89a294ccc6c7a0390","type":"text","conversion_output":true,"text":"Again a Borda count system will be used to rank in this cohort goals and goal categories that were most","text_display":"\n\nAgain a Borda count system will be used to rank in this cohort goals and goal categories that were most","confidence":1,"confidence_rate":1},{"cnt":[[146,2501],[1936,2501],[1936,2546],[146,2546]],"region":{"top_left_x":146,"top_left_y":2500,"width":1790,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"609c9208dd364f28b531df1d70953067","type":"text","conversion_output":true,"text":"likely to be achieved and we will describe the goals that were more likely to be achieved in this cohort at 6","text_display":" likely to be achieved and we will describe the goals that were more likely to be achieved in this cohort at 6","confidence":1,"confidence_rate":1},{"cnt":[[1038,2548],[1089,2548],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2548,"width":53,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ebfb4307cf04110be6d138bb443bad6","type":"page_info","conversion_output":false,"text":"57","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,2591],[312,2591],[312,2623],[146,2623]],"region":{"top_left_x":146,"top_left_y":2591,"width":166,"height":33},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3642483588c6449593ad7bf0e7549c1c","type":"page_info","conversion_output":false,"text":"Version 2.0","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"722dd686-9d24-4967-a9cf-6968feb8114e-58","page":58,"lines":[{"cnt":[[146,129],[406,129],[406,165],[146,165]],"region":{"top_left_x":146,"top_left_y":128,"width":261,"height":38},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5f9263dbf4646869d4161023013ae3b","type":"page_info","conversion_output":false,"text":"PFDN Protocol","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1770,129],[1910,129],[1910,165],[1770,165]],"region":{"top_left_x":1770,"top_left_y":128,"width":140,"height":38},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17868d82cb0442eba29cd9f4f1ad4ca2","type":"page_info","conversion_output":false,"text":"2-12-14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[150,172],[307,172],[307,208],[150,208]],"region":{"top_left_x":150,"top_left_y":171,"width":158,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e40fbe7e6db4c128a921cc3a175a370","type":"page_info","conversion_output":false,"text":"ESTEEM","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[146,215],[354,215],[354,251],[146,251]],"region":{"top_left_x":146,"top_left_y":214,"width":209,"height":38},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d673ff6e40f4310a2a456fcf732559f","type":"text","conversion_output":true,"text":"Confidential","text_display":"\n\nConfidential","confidence":1,"confidence_rate":1},{"cnt":[[146,260],[1936,260],[1936,303],[146,303]],"region":{"top_left_x":146,"top_left_y":259,"width":1790,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb5a1ad82ba546d19d26a37ae810715a","type":"text","conversion_output":true,"text":"months and one year. In the original validation study, a cut off T score of > 50 was determined to indicate","text_display":" months and one year. In the original validation study, a cut off T score of > 50 was determined to indicate","confidence":0.7014223821461201,"confidence_rate":0.9969208804065272},{"cnt":[[146,305],[1968,305],[1968,346],[146,346]],"region":{"top_left_x":146,"top_left_y":305,"width":1822,"height":41},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5db738e290e499181606964ef053869","type":"text","conversion_output":true,"text":"women who achieved their goals, versus women who scored \\(</=50\\) who did not achieve goals according to","text_display":" women who achieved their goals, versus women who scored \\(</=50\\) who did not achieve goals according to","confidence":0.9299771785736084,"confidence_rate":0.9993280477841847},{"cnt":[[146,348],[1888,348],[1888,391],[146,391]],"region":{"top_left_x":146,"top_left_y":348,"width":1743,"height":44},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04567156c7694252929ef350b1ee826a","type":"text","conversion_output":true,"text":"the formula provided by Kiresuk and Sherman (T-scores with mean \\(=50\\) and SD \\(=10\\) ). (Kiresuk, 1968)","text_display":" the formula provided by Kiresuk and Sherman (T-scores with mean \\(=50\\) and SD \\(=10\\) ). (Kiresuk, 1968)","confidence":0.7036444430567399,"confidence_rate":0.9967508261118218},{"cnt":[[146,391],[1936,391],[1936,436],[146,436]],"region":{"top_left_x":146,"top_left_y":391,"width":1790,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bf449e8b411420a8e34ebd195f75aa6","type":"text","conversion_output":true,"text":"Weights will be applied to women's individualized goal achievement ratings. We will compare women who","text_display":" Weights will be applied to women's individualized goal achievement ratings. We will compare women who","confidence":1,"confidence_rate":1},{"cnt":[[146,436],[1919,436],[1919,479],[146,479]],"region":{"top_left_x":146,"top_left_y":436,"width":1773,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22acbea44a3d4b08a9a828b2ced01a67","type":"text","conversion_output":true,"text":"achieve goals to those who do not at 6 and 12 months to determine both if there are baseline differences","text_display":" achieve goals to those who do not at 6 and 12 months to determine both if there are baseline differences","confidence":0.9975600242614746,"confidence_rate":0.999978757118413},{"cnt":[[146,481],[1970,481],[1970,522],[146,522]],"region":{"top_left_x":146,"top_left_y":481,"width":1825,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dab019c11dc742e0be358daa5d614a47","type":"text","conversion_output":true,"text":"between those women who achieve goals and do not, and if there is a different pattern of goal attainment at","text_display":" between those women who achieve goals and do not, and if there is a different pattern of goal attainment at","confidence":1,"confidence_rate":1},{"cnt":[[146,524],[1162,524],[1162,569],[146,569]],"region":{"top_left_x":146,"top_left_y":524,"width":1017,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"385f125fd93949f78c5c40132c3b145b","type":"text","conversion_output":true,"text":"short term ( 6 months) and longer term ( 12 month) follow up.","text_display":" short term ( 6 months) and longer term ( 12 month) follow up.","confidence":0.9361569437896833,"confidence_rate":0.9990841399120529},{"cnt":[[146,610],[1962,610],[1962,655],[146,655]],"region":{"top_left_x":146,"top_left_y":610,"width":1816,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23dae59258064aeab1fe04dc46c24ace","type":"text","conversion_output":true,"text":"Potential problems and Strategies to overcome them:It is possible that women will rank goal attainment","text_display":"\n\nPotential problems and Strategies to overcome them:It is possible that women will rank goal attainment","confidence":0.9965848922729492,"confidence_rate":0.9999680289922209},{"cnt":[[146,655],[1886,655],[1886,698],[146,698]],"region":{"top_left_x":146,"top_left_y":655,"width":1741,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b7afd0b75b44c438aa998d31fcc7cc6","type":"text","conversion_output":true,"text":"highly for all listed goals and that there will not be differences noted between continence goals and self","text_display":" highly for all listed goals and that there will not be differences noted between continence goals and self","confidence":1,"confidence_rate":1},{"cnt":[[146,700],[1841,700],[1841,741],[146,741]],"region":{"top_left_x":146,"top_left_y":700,"width":1696,"height":42},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b2cf72eefa1476984b59701796ab6eb","type":"text","conversion_output":true,"text":"stated goals. In this instance the data generated are still valuable because the negative findings are","text_display":" stated goals. In this instance the data generated are still valuable because the negative findings are","confidence":1,"confidence_rate":1},{"cnt":[[146,743],[834,743],[834,786],[146,786]],"region":{"top_left_x":146,"top_left_y":743,"width":688,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35a571049cfc464c9a0c4b2c1e09ef7b","type":"text","conversion_output":true,"text":"informative to the counseling of patients.","text_display":" informative to the counseling of patients.","confidence":1,"confidence_rate":1},{"cnt":[[146,829],[372,829],[372,874],[146,874]],"region":{"top_left_x":146,"top_left_y":829,"width":226,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f8d72ddcb864cb08edd396959ae8565","type":"section_header","conversion_output":false,"children_ids":["e79f11401121426eb427220deb8c1780"],"text":"","text_display":""},{"cnt":[[148,831],[372,831],[372,870],[148,870]],"region":{"top_left_x":148,"top_left_y":831,"width":224,"height":40},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e79f11401121426eb427220deb8c1780","type":"text","conversion_output":true,"parent_id":"3f8d72ddcb864cb08edd396959ae8565","text":"References:","text_display":"\n\n\\section*{References:}","confidence":1,"confidence_rate":1},{"cnt":[[146,920],[1835,920],[1835,965],[146,965]],"region":{"top_left_x":146,"top_left_y":919,"width":1689,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a55868d9f47e4dfcbe57e25aeb15c6e2","type":"text","conversion_output":true,"text":"Adams S, Dramitinos P, Shapiro A et al. Do patient goals vary with stage of prolapse? Am J Obstet","text_display":"\n\nAdams S, Dramitinos P, Shapiro A et al. Do patient goals vary with stage of prolapse? Am J Obstet","confidence":0.9834139309823513,"confidence_rate":0.9998360413057906},{"cnt":[[148,962],[634,962],[634,1008],[148,1008]],"region":{"top_left_x":148,"top_left_y":962,"width":486,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65e0df74c5e5488bac51e1096f0428ed","type":"text","conversion_output":true,"text":"Gynecol 2013; 205:502.e1-6","text_display":" Gynecol 2013; 205:502.e1-6","confidence":1,"confidence_rate":1},{"cnt":[[146,1053],[1910,1053],[1910,1094],[146,1094]],"region":{"top_left_x":146,"top_left_y":1052,"width":1764,"height":42},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a10a5ef608604aeea42a3f1cab9a5e5d","type":"text","conversion_output":true,"text":"Brubaker L, Piault EC, Tully SE et al. Validation study of the self-assessment goal achievement (SAGA)","text_display":"\n\nBrubaker L, Piault EC, Tully SE et al. Validation study of the self-assessment goal achievement (SAGA)","confidence":1,"confidence_rate":1},{"cnt":[[146,1096],[1592,1096],[1592,1139],[146,1139]],"region":{"top_left_x":146,"top_left_y":1095,"width":1446,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b51d28df4b145e59cb23bc592cb4ebc","type":"text","conversion_output":true,"text":"questionnaire for lower urinary tract symptoms. Int J Clin Pract 2013; 67(4): 342-350.","text_display":" questionnaire for lower urinary tract symptoms. Int J Clin Pract 2013; 67(4): 342-350.","confidence":0.9809904098510742,"confidence_rate":0.9997891145981848},{"cnt":[[148,1182],[1953,1182],[1953,1227],[148,1227]],"region":{"top_left_x":148,"top_left_y":1181,"width":1805,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af14852887ed4eb3a95ee07a4af6f953","type":"text","conversion_output":true,"text":"Brubaker L, Khullar V, Piault E et al. Goal attainment scaling in patients with lower urinary tract symptoms:","text_display":"\n\nBrubaker L, Khullar V, Piault E et al. Goal attainment scaling in patients with lower urinary tract symptoms:","confidence":1,"confidence_rate":1},{"cnt":[[148,1227],[1912,1227],[1912,1270],[148,1270]],"region":{"top_left_x":148,"top_left_y":1226,"width":1765,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27b74d0428f345fa9b7ac3be32109c41","type":"text","conversion_output":true,"text":"development and pilot testing of the Self-Assessment Goal Achievement questionnaire. Int Urogynecol J","text_display":" development and pilot testing of the Self-Assessment Goal Achievement questionnaire. Int Urogynecol J","confidence":1,"confidence_rate":1},{"cnt":[[150,1268],[475,1268],[475,1313],[150,1313]],"region":{"top_left_x":150,"top_left_y":1267,"width":325,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2311b280ff8d4083934cbd06928a6afd","type":"text","conversion_output":true,"text":"(2011) 22:937-946","text_display":" (2011) 22:937-946","confidence":1,"confidence_rate":1},{"cnt":[[148,1358],[1944,1358],[1944,1403],[148,1403]],"region":{"top_left_x":148,"top_left_y":1357,"width":1797,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d9b6aae18794589ba6d5bfaad72ac7f","type":"text","conversion_output":true,"text":"Elkadry EA, Kenton KS, FitzGerald MP, Shott S, Brubaker L. Patient-selected goals: a new perspective on","text_display":"\n\nElkadry EA, Kenton KS, FitzGerald MP, Shott S, Brubaker L. Patient-selected goals: a new perspective on","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[146,1401],[1596,1401],[1596,1446],[146,1446]],"region":{"top_left_x":146,"top_left_y":1400,"width":1451,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40c39ba0974742ec9ab1cf5adc7f1ad5","type":"text","conversion_output":true,"text":"surgical outcome. Am J Obstet Gynecol. 2003 Dec;189(6):1551-7; discussion 1557-8.","text_display":" surgical outcome. Am J Obstet Gynecol. 2003 Dec;189(6):1551-7; discussion 1557-8.","confidence":1,"confidence_rate":1},{"cnt":[[148,1491],[1949,1491],[1949,1532],[148,1532]],"region":{"top_left_x":148,"top_left_y":1491,"width":1801,"height":41},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56f6b04946404d2086b50d024948cd15","type":"text","conversion_output":true,"text":"Hullfish KL, Bovbjerg VE, Steers WD. Patient-centered goals for pelvic floor dysfunction surgery: long-term","text_display":"\n\nHullfish KL, Bovbjerg VE, Steers WD. Patient-centered goals for pelvic floor dysfunction surgery: long-term","confidence":1,"confidence_rate":1},{"cnt":[[146,1534],[1091,1534],[1091,1579],[146,1579]],"region":{"top_left_x":146,"top_left_y":1533,"width":946,"height":47},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72c05c39ac30499f8ca384a0cbc3959e","type":"text","conversion_output":true,"text":"follow-up. Am J Obstet Gynecol. 2004 Jul;191(1):201-5.","text_display":" follow-up. 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Clinical value of a patient-related goal attainment","confidence":1,"confidence_rate":1},{"cnt":[[146,1663],[1869,1663],[1869,1708],[146,1708]],"region":{"top_left_x":146,"top_left_y":1662,"width":1724,"height":47},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13b987535bf748f2ab352e5cb8ef6e7c","type":"text","conversion_output":true,"text":"measure: The global development of Self-Assessment Global Achievement (SAGA) Questionnaire for","text_display":" measure: The global development of Self-Assessment Global Achievement (SAGA) Questionnaire for","confidence":1,"confidence_rate":1},{"cnt":[[146,1710],[1695,1710],[1695,1751],[146,1751]],"region":{"top_left_x":146,"top_left_y":1710,"width":1550,"height":41},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"149071a47ec1419c892b7fbb32146e30","type":"text","conversion_output":true,"text":"patients with lower urinary tract symptoms. Neurourol Urodynam 2013; epub ahead of print.","text_display":" patients with lower urinary tract symptoms. Neurourol Urodynam 2013; epub ahead of print.","confidence":1,"confidence_rate":1},{"cnt":[[146,1796],[1940,1796],[1940,1841],[146,1841]],"region":{"top_left_x":146,"top_left_y":1796,"width":1795,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e9a658f114b4e59a85b8971879a8714","type":"text","conversion_output":true,"text":"Khullar V, Marschall-Kehrel D, Espuna-Pons M et al. European content validation of the Self-Assessment","text_display":"\n\nKhullar V, Marschall-Kehrel D, Espuna-Pons M et al. 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