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For Regimen B, patients will receive two","confidence":0.96142578125,"confidence_rate":0.9995815991761721},{"cnt":[[245,1392],[1880,1392],[1880,1437],[245,1437]],"region":{"top_left_x":244,"top_left_y":1392,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29413941bd0c4c5bb39c6a50ac7e66ab","type":"text","conversion_output":true,"text":"myeloablative consolidations: Thiotepa - cyclophosphamide (TC) preparative regimen followed by CEM","text_display":" myeloablative consolidations: Thiotepa - cyclophosphamide (TC) preparative regimen followed by CEM","confidence":1,"confidence_rate":1},{"cnt":[[245,1435],[569,1435],[569,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1435,"width":326,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d76bf031d7c149a0ac268c5e686f15c6","type":"text","conversion_output":true,"text":"preparative regimen.","text_display":" preparative regimen.","confidence":0.99951171875,"confidence_rate":0.9999804641709025},{"cnt":[[245,1530],[1880,1530],[1880,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a24504396f3a444b856f4329bd529b8b","type":"text","conversion_output":true,"text":"Most patients will be randomized into either Regimen A or Regimen B. Randomization will be","text_display":"\n\nMost patients will be randomized into either Regimen A or Regimen B. Randomization will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1880,1573],[1880,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1572,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"715d9a4bdbd942b7897dd4fef61b9d41","type":"text","conversion_output":true,"text":"stratified by stage, MYCN status and response to induction therapy. Patients 365 to 547 days of age ( 12","text_display":" stratified by stage, MYCN status and response to induction therapy. Patients 365 to 547 days of age ( 12","confidence":0.959364652633667,"confidence_rate":0.9996361711684938},{"cnt":[[245,1616],[1880,1616],[1880,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1615,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d6a31cf84c8489c937e01eba66ef5e4","type":"text","conversion_output":true,"text":"- 18 months) with Stage 4, MYCN nonamplified tumor with unfavorable histopathology or diploid","text_display":" - 18 months) with Stage 4, MYCN nonamplified tumor with unfavorable histopathology or diploid","confidence":0.9015607740730047,"confidence_rate":0.9989745081149708},{"cnt":[[245,1659],[1882,1659],[1882,1706],[245,1706]],"region":{"top_left_x":244,"top_left_y":1658,"width":1639,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e204af0b00704eefab639ba3cfb4c660","type":"text","conversion_output":true,"text":"DNA content or with indeterminant histology or ploidy and patients who are greater than 547 days of","text_display":" DNA content or with indeterminant histology or ploidy and patients who are greater than 547 days of","confidence":0.9746654033660889,"confidence_rate":0.9997602059241922},{"cnt":[[245,1704],[1880,1704],[1880,1749],[245,1749]],"region":{"top_left_x":244,"top_left_y":1703,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bce916239c8349d69d386a389fd440fe","type":"text","conversion_output":true,"text":"age with Stage 3, MYCN nonamplified tumor AND unfavorable histopathology or indeterminant","text_display":" age with Stage 3, MYCN nonamplified tumor AND unfavorable histopathology or indeterminant","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1635,1749],[1635,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1391,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b109a907782a403c9b14c546f349a9db","type":"text","conversion_output":true,"text":"histology will be nonrandomly assigned to single myeloablative transplant (Regimen A).","text_display":" histology will be nonrandomly assigned to single myeloablative transplant (Regimen A).","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1878,1835],[1878,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1834,"width":1634,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0fa04556c5d471a9c86a1d4dd8d46a8","type":"text","conversion_output":true,"text":"ANBL0532 will also assess the efficacy of a dose intensive topotecan containing induction regimen,","text_display":"\n\nANBL0532 will also assess the efficacy of a dose intensive topotecan containing induction regimen,","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1882,1878],[1882,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1877,"width":1639,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be6690120adb45849f99d5fefb9099ad","type":"text","conversion_output":true,"text":"substituting 2 cycles of dose intensive cyclophosphamide and topotecan for the initial 2 cycles of","text_display":" substituting 2 cycles of dose intensive cyclophosphamide and topotecan for the initial 2 cycles of","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1880,1921],[1880,1968],[245,1968]],"region":{"top_left_x":244,"top_left_y":1920,"width":1636,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b0d265392a64fac9258b3134c2a4d12","type":"text","conversion_output":true,"text":"induction utilized on the prior COG A3973 protocol. Patients will receive 6 cycles of induction","text_display":" induction utilized on the prior COG A3973 protocol. Patients will receive 6 cycles of induction","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1880,1968],[1880,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1967,"width":1636,"height":47},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24f1fd9ecf204beeb85176bf861a5f01","type":"text","conversion_output":true,"text":"chemotherapy as outlined in the schema below. Patients will undergo peripheral blood stem cell (PBSC)","text_display":" chemotherapy as outlined in the schema below. Patients will undergo peripheral blood stem cell (PBSC)","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1880,2011],[1880,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2010,"width":1636,"height":47},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"263d961662004cbb8724e568e64d8b57","type":"text","conversion_output":true,"text":"harvest after 2 cycles with no ex vivo manipulation prior to cryopreservation. PBSC collection will be","text_display":" harvest after 2 cycles with no ex vivo manipulation prior to cryopreservation. PBSC collection will be","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,2050],[1880,2050],[1880,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2049,"width":1636,"height":51},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4d5948b7a7749e68bda54a2f5647840","type":"text","conversion_output":true,"text":"performed prior to randomization. The goal of apheresis will be collection of \\(10 \\times 10^{6} CD 34+ cells / kg\\)","text_display":" performed prior to randomization. The goal of apheresis will be collection of \\(10 \\times 10^{6} CD 34+ cells / kg\\)","confidence":0.5182923123356886,"confidence_rate":0.9943985173384864},{"cnt":[[245,2093],[1880,2093],[1880,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2092,"width":1636,"height":50},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d77b1b40f51c4d1185b493fbf7bb2b4a","type":"text","conversion_output":true,"text":"divided into 3 aliquots. A minimum collection of \\(4 \\times 10^{6} CD 34+ cells / kg\\), divided into 2 aliquots is","text_display":" divided into 3 aliquots. A minimum collection of \\(4 \\times 10^{6} CD 34+ cells / kg\\), divided into 2 aliquots is","confidence":0.90869140625,"confidence_rate":0.9992403701766978},{"cnt":[[245,2138],[1880,2138],[1880,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2137,"width":1636,"height":53},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08e1ad7059c944cc8fe2d5809e9617f1","type":"text","conversion_output":true,"text":"required for each patient while an additional \\(3^{\\text {rd }}\\) aliquot of \\(2 \\times 10^{6} CD 34+ cells / kg\\) is strongly","text_display":" required for each patient while an additional \\(3^{\\text {rd }}\\) aliquot of \\(2 \\times 10^{6} CD 34+ cells / kg\\) is strongly","confidence":0.6396481583618652,"confidence_rate":0.9965686926950401},{"cnt":[[245,2187],[1880,2187],[1880,2232],[245,2232]],"region":{"top_left_x":244,"top_left_y":2187,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3663d3a3d844b3ab57a4bcf673c9151","type":"text","conversion_output":true,"text":"recommended to be stored as backup for delayed engraftment or for future use. Tumor response will be","text_display":" recommended to be stored as backup for delayed engraftment or for future use. Tumor response will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1878,2230],[1878,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2230,"width":1634,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21ddbe0880b84a4f91e97701bb23a1c6","type":"text","conversion_output":true,"text":"assessed after 2 cycles of induction chemotherapy. Patients will undergo surgical resection after Cycle 5","text_display":" assessed after 2 cycles of induction chemotherapy. Patients will undergo surgical resection after Cycle 5","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1882,2273],[1882,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2273,"width":1639,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a35e04bdf2e8402d94eada0864f11756","type":"text","conversion_output":true,"text":"(or 6 if necessary). Tumor response will be assessed after completion of surgical resection and 6 cycles of","text_display":" (or 6 if necessary). Tumor response will be assessed after completion of surgical resection and 6 cycles of","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1880,2316],[1880,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2316,"width":1636,"height":50},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cb551b26d5e4cd3962e4addf2067377","type":"text","conversion_output":true,"text":"chemotherapy (end-induction). Patients with progressive disease (PD) at end of induction evaluation will","text_display":" chemotherapy (end-induction). Patients with progressive disease (PD) at end of induction evaluation will","confidence":1,"confidence_rate":1},{"cnt":[[245,2363],[1360,2363],[1360,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2363,"width":1116,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ddef8f46721487db92fea5eba3d0ce5","type":"text","conversion_output":true,"text":"be taken off protocol therapy, all other patients will continue on therapy.","text_display":" be taken off protocol therapy, all other patients will continue on therapy.","confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[245,2449],[1880,2449],[1880,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2449,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b052c95c226c450fa2a1254d1bad99c9","type":"text","conversion_output":true,"text":"ANBL0532 will also test whether additional radiation therapy delivered to gross residual disease","text_display":"\n\nANBL0532 will also test whether additional radiation therapy delivered to gross residual disease","confidence":1,"confidence_rate":1},{"cnt":[[245,2492],[1882,2492],[1882,2539],[245,2539]],"region":{"top_left_x":244,"top_left_y":2492,"width":1639,"height":48},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74f65f10dd4c47b99190521e01bfd882","type":"text","conversion_output":true,"text":"improves local control for those patients with less than a gross total resection. After completion of","text_display":" improves local control for those patients with less than a gross total resection. 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Patients who achieve end of","text_display":"\nand to MIBG-avid sites seen at pre-transplant (end-induction) evaluation. Patients who achieve end of","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,271],[1880,271],[1880,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ecf6be0769c4b80bb65e3bc765d1f75","type":"text","conversion_output":true,"text":"induction primary site complete response (CR) will receive 21.6 Gy external beam radiation therapy","text_display":" induction primary site complete response (CR) will receive 21.6 Gy external beam radiation therapy","confidence":0.9990234375,"confidence_rate":0.9999907826873115},{"cnt":[[245,309],[1880,309],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":309,"width":1636,"height":55},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56fd0e1ffc034249b149e26aa667b208","type":"text","conversion_output":true,"text":"(EBRT) to the primary site (standard dose) while patients achieving \\(< CR\\) ( \\(\\geq 1 cm^{3}\\) residual soft tissue) at","text_display":" (EBRT) to the primary site (standard dose) while patients achieving \\(< CR\\) ( \\(\\geq 1 cm^{3}\\) residual soft tissue) at","confidence":0.5568811647244476,"confidence_rate":0.9954369782164633},{"cnt":[[245,361],[1880,361],[1880,406],[245,406]],"region":{"top_left_x":244,"top_left_y":360,"width":1636,"height":47},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71cc9a974a3e4bb78e1edee88869e5f8","type":"text","conversion_output":true,"text":"the primary site will receive an additional boost of 14.4 Gy for a total dose of 36 Gy EBRT delivered to","text_display":" the primary site will receive an additional boost of 14.4 Gy for a total dose of 36 Gy EBRT delivered to","confidence":0.998046875,"confidence_rate":0.9999829998415843},{"cnt":[[245,404],[1880,404],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":403,"width":1636,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b1f7046cbc0461b8f28f7e6e43d5e22","type":"text","conversion_output":true,"text":"gross residual primary site disease. Pre-surgical and end of induction CT or MRI scans and operative","text_display":" gross residual primary site disease. Pre-surgical and end of induction CT or MRI scans and operative","confidence":1,"confidence_rate":1},{"cnt":[[245,447],[1880,447],[1880,492],[245,492]],"region":{"top_left_x":244,"top_left_y":446,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c752c236b7b2413da959c04536226a8b","type":"text","conversion_output":true,"text":"reports will be centrally reviewed in real time for all patients assessed by the treating institution to have a","text_display":" reports will be centrally reviewed in real time for all patients assessed by the treating institution to have a","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[245,490],[1880,490],[1880,537],[245,537]],"region":{"top_left_x":244,"top_left_y":489,"width":1636,"height":49},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20dc1714da6c4631a211ec89b0473d73","type":"text","conversion_output":true,"text":"complete response at the primary site at the end of induction. Tumor response will be assessed after","text_display":" complete response at the primary site at the end of induction. 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EFS.","text_display":" after single versus tandem myeloablative chemotherapy and to evaluate impact on EFS.","confidence":0.9990234375,"confidence_rate":0.9999890220866866},{"cnt":[[249,842],[350,842],[350,879],[249,879]],"region":{"top_left_x":249,"top_left_y":842,"width":102,"height":37},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43912586e7e9446492b4041ef11a1b1f","type":"text","conversion_output":true,"text":"1.2.10","text_display":"\n1.2.10","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1880,885],[1880,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"387b9e508f5c4b41b0a0ce4ba3430fb5","type":"text","conversion_output":true,"text":"To evaluate the EFS and OS rate for patients \\(12-18\\) months with Stage 4, \\(M Y C N\\) nonamplified tumor with","text_display":"\n\nTo evaluate the EFS and OS rate for patients \\(12-18\\) months with Stage 4, \\(M Y C N\\) nonamplified tumor with","confidence":0.5971993154196298,"confidence_rate":0.9953665841244227},{"cnt":[[245,930],[1880,930],[1880,973],[245,973]],"region":{"top_left_x":244,"top_left_y":930,"width":1636,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4b6d108df5348a1b6b7c12db26219af","type":"text","conversion_output":true,"text":"unfavorable histopathology or diploid DNA content or with indeterminant histology or ploidy and patients","text_display":" unfavorable histopathology or diploid DNA content or with indeterminant histology or ploidy and patients","confidence":1,"confidence_rate":1},{"cnt":[[245,975],[1880,975],[1880,1018],[245,1018]],"region":{"top_left_x":244,"top_left_y":975,"width":1636,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3394ea24b1674befb8006f3c1d3877d7","type":"text","conversion_output":true,"text":"who are greater than 547 days of age with Stage 3, MYCN nonamplified tumor AND unfavorable","text_display":" who are greater than 547 days of age with Stage 3, MYCN nonamplified tumor AND unfavorable","confidence":0.5945813655853271,"confidence_rate":0.9947089684221676},{"cnt":[[245,1018],[1729,1018],[1729,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1018,"width":1486,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"961ab915f7cb407e8d0efea8a5dcb2be","type":"text","conversion_output":true,"text":"histopathology or indeterminant histology following treatment with single myeloablative transplant.","text_display":" histopathology or indeterminant histology following treatment with single myeloablative 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BACKGROUND}","confidence":0.99951171875,"confidence_rate":0.999974295041004},{"cnt":[[245,1238],[1880,1238],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1237,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cff39c3e6ad444c799c99c8b7e95d6ca","type":"text","conversion_output":true,"text":"Neuroblastoma, a neoplasm of the sympathetic nervous system, is the second most extracranial malignant","text_display":"\n\nNeuroblastoma, a neoplasm of the sympathetic nervous system, is the second most extracranial malignant","confidence":1,"confidence_rate":1},{"cnt":[[245,1278],[1880,1278],[1880,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1278,"width":1636,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13d49fbca964451990909fb811c712ec","type":"text","conversion_output":true,"text":"solid tumor of childhood. \\({ }^{1}\\) The current survival for a child \\(>1\\) year at diagnosis with Stage 4","text_display":" solid tumor of childhood. \\({ }^{1}\\) The current survival for a child \\(>1\\) year at diagnosis with Stage 4","confidence":0.80810546875,"confidence_rate":0.9980823572619352},{"cnt":[[245,1319],[1882,1319],[1882,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1319,"width":1639,"height":52},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a3b14429ada40b2bf90439803e13808","type":"text","conversion_output":true,"text":"neuroblastoma is only \\(20-35 \\% .^{2-7}\\) Novel therapies to improve initial disease response and treatment of","text_display":" neuroblastoma is only \\(20-35 \\% .^{2-7}\\) Novel therapies to improve initial disease response and treatment of","confidence":0.9980475902557373,"confidence_rate":0.999983152571397},{"cnt":[[245,1371],[1876,1371],[1876,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1370,"width":1632,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"720f80f9d4b248a597ac730353c6a27d","type":"text","conversion_output":true,"text":"minimal residual disease are required to improve survival for these children with high-risk neuroblastoma.","text_display":" minimal residual disease are required to improve survival for these children with high-risk neuroblastoma.","confidence":1,"confidence_rate":1},{"cnt":[[245,1414],[1878,1414],[1878,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1413,"width":1634,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50984526befc48ceb3f34a0bb7fa79ca","type":"text","conversion_output":true,"text":"Standard therapy for patients with high-risk neuroblastoma involves at least 4 components: Induction,","text_display":" Standard therapy for patients with high-risk neuroblastoma involves at least 4 components: Induction,","confidence":1,"confidence_rate":1},{"cnt":[[245,1457],[1878,1457],[1878,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1456,"width":1634,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad5d9c8daca44e669bddeca0b468b1c7","type":"text","conversion_output":true,"text":"Local Control, Consolidation and Treatment of minimal disease with biologic agents. The use of these 4","text_display":" Local Control, Consolidation and Treatment of minimal disease with biologic agents. The use of these 4","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1545],[245,1545]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03d6e616b4bf426c84d06ddea969e0cf","type":"text","conversion_output":true,"text":"components has evolved over the last 20 years, based upon work by the POG and CCG, international","text_display":" components has evolved over the last 20 years, based upon work by the POG and CCG, international","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[965,1543],[965,1590],[245,1590]],"region":{"top_left_x":244,"top_left_y":1542,"width":721,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd1552a29bdc4cc9a0d4ffa940eb559d","type":"text","conversion_output":true,"text":"cooperative groups and smaller cohort studies.","text_display":" cooperative groups and smaller cohort studies.","confidence":1,"confidence_rate":1},{"cnt":[[245,1629],[1880,1629],[1880,1674],[245,1674]],"region":{"top_left_x":244,"top_left_y":1628,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3a9485c3f5b42308c554b01be6cce7b","type":"text","conversion_output":true,"text":"The primary aim of ANBL0532 is to improve event free survival for children with high-risk","text_display":"\n\nThe primary aim of ANBL0532 is to improve event free survival for children with high-risk","confidence":1,"confidence_rate":1},{"cnt":[[245,1671],[1880,1671],[1880,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1671,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd6dcd1af01f42afa6aa40c634df7a0b","type":"text","conversion_output":true,"text":"neuroblastoma. This study is a logical extension of the COG Neuroblastoma committee's strategic plan","text_display":" neuroblastoma. This study is a logical extension of the COG Neuroblastoma committee's strategic plan","confidence":1,"confidence_rate":1},{"cnt":[[245,1714],[1880,1714],[1880,1762],[245,1762]],"region":{"top_left_x":244,"top_left_y":1714,"width":1636,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4782668a670f47e7a6eeb3ef61e40e0c","type":"text","conversion_output":true,"text":"and will build upon our previous findings to study the use of intensified consolidation (Primary Aim 1),","text_display":" and will build upon our previous findings to study the use of intensified consolidation (Primary Aim 1),","confidence":1,"confidence_rate":1},{"cnt":[[245,1762],[1880,1762],[1880,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1761,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5377f33c55094c7d8f5f9051f4c28eee","type":"text","conversion_output":true,"text":"the use of a novel induction regimen (Primary Aim 2), and the use of increased dose local radiation","text_display":" the use of a novel induction regimen (Primary Aim 2), and the use of increased dose local radiation","confidence":1,"confidence_rate":1},{"cnt":[[245,1805],[1880,1805],[1880,1850],[245,1850]],"region":{"top_left_x":244,"top_left_y":1804,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b51ad1ce1a1449f7b2a2b596281cd2d2","type":"text","conversion_output":true,"text":"therapy (Primary Aim 3). Specifically, a limited institution pilot study through COG (ANBL00P1) has","text_display":" therapy (Primary Aim 3). Specifically, a limited institution pilot study through COG (ANBL00P1) has","confidence":1,"confidence_rate":1},{"cnt":[[245,1848],[1880,1848],[1880,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1847,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b1f7aa886334728bdc49de258d416bb","type":"text","conversion_output":true,"text":"demonstrated the feasibility and tolerable toxicity of the proposed tandem transplant consolidation","text_display":" demonstrated the feasibility and tolerable toxicity of the proposed tandem transplant consolidation","confidence":1,"confidence_rate":1},{"cnt":[[245,1893],[1880,1893],[1880,1938],[245,1938]],"region":{"top_left_x":244,"top_left_y":1892,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be7c7f7c2fd34607a90585d4c7cf0597","type":"text","conversion_output":true,"text":"regimen. An additional limited institution pilot study through COG (ANBL02P1) has demonstrated","text_display":" regimen. An additional limited institution pilot study through COG (ANBL02P1) has demonstrated","confidence":1,"confidence_rate":1},{"cnt":[[245,1936],[1880,1936],[1880,1983],[245,1983]],"region":{"top_left_x":244,"top_left_y":1935,"width":1636,"height":49},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16c39bcd417e414ab9cf9cf2d16fb85b","type":"text","conversion_output":true,"text":"feasibility/tolerable toxicity of the dose intensive cyclophosphamide/topotecan administration proposed in","text_display":" feasibility/tolerable toxicity of the dose intensive cyclophosphamide/topotecan administration proposed in","confidence":1,"confidence_rate":1},{"cnt":[[245,1981],[1880,1981],[1880,2026],[245,2026]],"region":{"top_left_x":244,"top_left_y":1980,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7679e273b8db47aaaaf16d8e8101d9e2","type":"text","conversion_output":true,"text":"the induction phase and ability to harvest PBSC following such chemotherapy. ANBL0532 will also test","text_display":" the induction phase and ability to harvest PBSC following such chemotherapy. ANBL0532 will also test","confidence":1,"confidence_rate":1},{"cnt":[[245,2024],[1880,2024],[1880,2069],[245,2069]],"region":{"top_left_x":244,"top_left_y":2023,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94263bf1938f4ac4a9e3471e98f17243","type":"text","conversion_output":true,"text":"whether additional radiation therapy will improve local control for those patients with less than a gross","text_display":" whether additional radiation therapy will improve local control for those patients with less than a gross","confidence":1,"confidence_rate":1},{"cnt":[[245,2067],[1880,2067],[1880,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2066,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36b6faa2547c4cd78b82e717680b0014","type":"text","conversion_output":true,"text":"total resection, a hypothesis derived directly from retrospective analysis of the prior CCG 3891 high-risk","text_display":" total resection, a hypothesis derived directly from retrospective analysis of the prior CCG 3891 high-risk","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1880,2105],[1880,2157],[245,2157]],"region":{"top_left_x":244,"top_left_y":2105,"width":1636,"height":53},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1af01b676c4c45d48c3ea34c5396ce34","type":"text","conversion_output":true,"text":"neuroblastoma protocol. \\({ }^{8}\\) Patients completing this study will be eligible for COG ANBL0032 or","text_display":" neuroblastoma protocol. \\({ }^{8}\\) Patients completing this study will be eligible for COG ANBL0032 or","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[245,2155],[1485,2155],[1485,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2154,"width":1241,"height":49},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0928d83cd95a4eb2a99c27c208d90d35","type":"text","conversion_output":true,"text":"ANBL0931, a study of immunotherapy as treatment of minimal residual disease.","text_display":" ANBL0931, a study of immunotherapy as treatment of minimal residual disease.","confidence":1,"confidence_rate":1},{"cnt":[[240,2292],[241,2241],[1025,2243],[1025,2294]],"region":{"top_left_x":240,"top_left_y":2240,"width":785,"height":55},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd98ee188d1b40b098f5248cc79edd53","type":"section_header","conversion_output":false,"children_ids":["53427273e0834976976059810e4c8cd2"],"text":"","text_display":""},{"cnt":[[245,2245],[1021,2245],[1021,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2245,"width":777,"height":44},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53427273e0834976976059810e4c8cd2","type":"text","conversion_output":true,"parent_id":"dd98ee188d1b40b098f5248cc79edd53","text":"2.1 Definition of High-Risk Neuroblastoma","text_display":"\n\n\\subsection*{2.1 Definition of High-Risk Neuroblastoma}","confidence":0.99853515625,"confidence_rate":0.9999681327320658},{"cnt":[[245,2288],[1880,2288],[1880,2331],[245,2331]],"region":{"top_left_x":244,"top_left_y":2288,"width":1636,"height":44},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b5af8d115444cf0ad99082d7f147604","type":"text","conversion_output":true,"text":"Patients eligible for ANBL0532 must have high-risk neuroblastoma as defined by risk criteria that include","text_display":"\n\nPatients eligible for ANBL0532 must have high-risk neuroblastoma as defined by risk criteria that include","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,2331],[1880,2331],[1880,2378],[245,2378]],"region":{"top_left_x":244,"top_left_y":2331,"width":1636,"height":48},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08e9d2ff917345a1bb459ec45077bad3","type":"text","conversion_output":true,"text":"age, stage, and the biologic features of MYCN amplification, histopathology, and DNA ploidy (Appendix","text_display":" age, stage, and the biologic features of MYCN amplification, histopathology, and DNA ploidy (Appendix","confidence":0.6259765625,"confidence_rate":0.9955904831532072},{"cnt":[[245,2376],[1880,2376],[1880,2421],[245,2421]],"region":{"top_left_x":244,"top_left_y":2376,"width":1636,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4be3ee7f7e9646058fdad35b66469f7c","type":"text","conversion_output":true,"text":"VII). The stratification algorithm to be used for ANBL0532 and ANBL0531 (Intermediate Risk","text_display":" VII). The stratification algorithm to be used for ANBL0532 and ANBL0531 (Intermediate Risk","confidence":1,"confidence_rate":1},{"cnt":[[245,2419],[1880,2419],[1880,2464],[245,2464]],"region":{"top_left_x":244,"top_left_y":2419,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81d68c16a86341e691e0431e1fd18921","type":"text","conversion_output":true,"text":"Neuroblastoma clinical trial) has been revised from recent clinical trials and is based upon data from","text_display":" Neuroblastoma clinical trial) has been revised from recent clinical trials and is based upon data from","confidence":1,"confidence_rate":1},{"cnt":[[245,2462],[1880,2462],[1880,2507],[245,2507]],"region":{"top_left_x":244,"top_left_y":2462,"width":1636,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe34db0445c44559804dba6fe45e10f4","type":"text","conversion_output":true,"text":"legacy CCG and POG clinical trials. These data suggest that patients up to 18 months of age who are","text_display":" legacy CCG and POG clinical trials. These data suggest that patients up to 18 months of age who are","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,2505],[1880,2505],[1880,2550],[245,2550]],"region":{"top_left_x":244,"top_left_y":2505,"width":1636,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a864284dac3428f9ee792d90e0be837","type":"text","conversion_output":true,"text":"diagnosed with biologically favorable stage 4 neuroblastoma share the same excellent prognosis that has","text_display":" diagnosed with biologically favorable stage 4 neuroblastoma share the same excellent prognosis that has","confidence":1,"confidence_rate":1},{"cnt":[[245,2550],[1880,2550],[1880,2597],[245,2597]],"region":{"top_left_x":244,"top_left_y":2550,"width":1636,"height":48},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a31d430bbf9c4952a2700f931d5c7c58","type":"text","conversion_output":true,"text":"previously been demonstrated for infants less than 12 months of age with non-amplification of MYCN","text_display":" previously been demonstrated for infants less than 12 months of age with non-amplification of MYCN","confidence":0.90185546875,"confidence_rate":0.9990259369156578},{"cnt":[[1749,2608],[1876,2608],[1876,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":128,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"220ddb5f0f194ebcb1485ce01755e769","type":"page_info","conversion_output":false,"text":"Page 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Group","confidence":1,"confidence_rate":1},{"cnt":[[245,219],[1882,219],[1882,273],[245,273]],"region":{"top_left_x":244,"top_left_y":219,"width":1639,"height":54},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf6af25a3f94466c932d3fcb6cbbd793","type":"text","conversion_output":true,"text":"oncogene (MYCN-NA) stage 4 disease. \\({ }^{9}\\) Data from CCG 3881 and 3891 trials demonstrated a 6-year","text_display":"\noncogene (MYCN-NA) stage 4 disease. \\({ }^{9}\\) Data from CCG 3881 and 3891 trials demonstrated a 6-year","confidence":0.9878488748974387,"confidence_rate":0.9998963989808202},{"cnt":[[245,271],[1880,271],[1880,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c3ddb3f4a5948e8acb9101136577599","type":"text","conversion_output":true,"text":"\\(EFS =90 \\%\\) for infants \\(<12\\) months, \\(EFS =86.7 \\%\\) for toddlers \\(12-18\\) months, and \\(EFS =36.6 \\%\\) for children","text_display":" \\(EFS =90 \\%\\) for infants \\(<12\\) months, \\(EFS =86.7 \\%\\) for toddlers \\(12-18\\) months, and \\(EFS =36.6 \\%\\) for children","confidence":0.9975595474243164,"confidence_rate":0.9999796382461874},{"cnt":[[245,309],[1880,309],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":309,"width":1636,"height":55},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebf46609e92f490688e271a80a4dc246","type":"text","conversion_output":true,"text":"18-24 months of age at diagnosis of stage \\(4, M Y C N\\)-NA neuroblastoma. \\({ }^{10}\\) In this analysis, Shimada","text_display":" 18-24 months of age at diagnosis of stage \\(4, M Y C N\\)-NA neuroblastoma. \\({ }^{10}\\) In this analysis, Shimada","confidence":0.6479013313021889,"confidence_rate":0.9962000726209221},{"cnt":[[245,357],[1880,357],[1880,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":1636,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db57c4e0c75f4c019b2fc9a88a330711","type":"text","conversion_output":true,"text":"histology also correlated with age at diagnosis and survival, with nearly all patients with favorable","text_display":" histology also correlated with age at diagnosis and survival, with nearly all patients with favorable","confidence":1,"confidence_rate":1},{"cnt":[[245,400],[1880,400],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":399,"width":1636,"height":51},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f52222347bba4e649151aaf84746b2fb","type":"text","conversion_output":true,"text":"Shimada histology (FH) tumors being in the 12-18 month age group. Data from POG clinical trials also","text_display":" Shimada histology (FH) tumors being in the 12-18 month age group. Data from POG clinical trials also","confidence":0.9956088066101074,"confidence_rate":0.9999580878974093},{"cnt":[[245,447],[1880,447],[1880,494],[245,494]],"region":{"top_left_x":244,"top_left_y":446,"width":1636,"height":49},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51152728d88b48a099218eaa34d153d4","type":"text","conversion_output":true,"text":"suggest a favorable outcome for toddlers ages 12-18 months with stage D, MYCN-NA, hyperdiploid","text_display":" suggest a favorable outcome for toddlers ages 12-18 months with stage D, MYCN-NA, hyperdiploid","confidence":0.5234137721181469,"confidence_rate":0.9934821121995706},{"cnt":[[245,490],[1880,490],[1880,535],[245,535]],"region":{"top_left_x":244,"top_left_y":489,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a01e57a062ba4f9ea897536151b3eb3c","type":"text","conversion_output":true,"text":"tumors, treated on a variety of POG protocols with a 4 - year EFS of \\(>80 \\%,>90 \\%\\), and \\(<40 \\%\\) for patients","text_display":" tumors, treated on a variety of POG protocols with a 4 - year EFS of \\(>80 \\%,>90 \\%\\), and \\(<40 \\%\\) for patients","confidence":0.987809411833382,"confidence_rate":0.9998942684964772},{"cnt":[[245,529],[1880,529],[1880,580],[245,580]],"region":{"top_left_x":244,"top_left_y":528,"width":1636,"height":53},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f641278dfbe4484a73c96488ec08677","type":"text","conversion_output":true,"text":"age 6-12 months, 12-18 months, and 18-24 months, respectively, at diagnosis. \\({ }^{11}\\) Further analyses of CCG","text_display":" age 6-12 months, 12-18 months, and 18-24 months, respectively, at diagnosis. \\({ }^{11}\\) Further analyses of CCG","confidence":0.9951171875,"confidence_rate":0.9999585197384931},{"cnt":[[245,576],[1880,576],[1880,625],[245,625]],"region":{"top_left_x":244,"top_left_y":575,"width":1636,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d650e6849b8240aa8feada8cc8d64cb0","type":"text","conversion_output":true,"text":"3891 data reveal an excellent outcome for the rare patient age 12-18 months with stage 3, MYCN-NA but","text_display":" 3891 data reveal an excellent outcome for the rare patient age 12-18 months with stage 3, MYCN-NA but","confidence":0.8775872762780637,"confidence_rate":0.9987571646894363},{"cnt":[[245,623],[1880,623],[1880,668],[245,668]],"region":{"top_left_x":244,"top_left_y":623,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffe8a5b5b0114084b955cba615b867b0","type":"text","conversion_output":true,"text":"unfavorable Shimada histology (UH) disease. Measurement of tumor DNA index was not performed in","text_display":" unfavorable Shimada histology (UH) disease. Measurement of tumor DNA index was not performed in","confidence":1,"confidence_rate":1},{"cnt":[[245,666],[1880,666],[1880,711],[245,711]],"region":{"top_left_x":244,"top_left_y":666,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef9e35a99a1d4f17b40b93c3f701fe8f","type":"text","conversion_output":true,"text":"this study. The 3 -year EFS/OS was \\(100 \\%\\) for patients \\(12-18\\) months with Stage 3, MYCN-NA and UH","text_display":" this study. The 3 -year EFS/OS was \\(100 \\%\\) for patients \\(12-18\\) months with Stage 3, MYCN-NA and UH","confidence":0.48479489148620775,"confidence_rate":0.9933184457570814},{"cnt":[[245,705],[608,705],[608,758],[245,758]],"region":{"top_left_x":244,"top_left_y":704,"width":365,"height":55},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00222e2014ac48aab04d8a29094d658d","type":"text","conversion_output":true,"text":"neuroblastoma ( \\(n =3\\) ). \\({ }^{12}\\)","text_display":" neuroblastoma ( \\(n =3\\) ). \\({ }^{12}\\)","confidence":0.8774199881590903,"confidence_rate":0.9968912823532067},{"cnt":[[245,797],[1880,797],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":797,"width":1636,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81c88aa13d0a4ee599b643c0bd1d0c06","type":"text","conversion_output":true,"text":"Based upon these data, ANBL0532 will exclude patients age 12-18 months with stage 4, MYCN-NA,","text_display":"\n\nBased upon these data, ANBL0532 will exclude patients age 12-18 months with stage 4, MYCN-NA,","confidence":0.7593395997488983,"confidence_rate":0.9971946955964814},{"cnt":[[245,838],[1880,838],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":837,"width":1636,"height":51},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b9dbcfca4584ff9b10fa4ff05b0ef38","type":"text","conversion_output":true,"text":"hyperdiploid, and FH tumors or stage \\(3 M Y C N\\)-NA, unfavorable histopathology. These patients will be","text_display":" hyperdiploid, and FH tumors or stage \\(3 M Y C N\\)-NA, unfavorable histopathology. These patients will be","confidence":0.9026838303543627,"confidence_rate":0.999034589710791},{"cnt":[[245,885],[1880,885],[1880,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64cdc18f637b47d59bf5b84debd1ba85","type":"text","conversion_output":true,"text":"treated on the intermediate-risk protocol, ANBL0531, representing a reduction of therapy in both dose-","text_display":" treated on the intermediate-risk protocol, ANBL0531, representing a reduction of therapy in both dose","confidence":1,"confidence_rate":1},{"cnt":[[245,928],[1880,928],[1880,975],[245,975]],"region":{"top_left_x":244,"top_left_y":928,"width":1636,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99456749046041e39be12c2592ccac77","type":"text","conversion_output":true,"text":"intensity and cumulative dose. Of note, this clinically favorable cohort of 12-18 month old patients with","text_display":"intensity and cumulative dose. Of note, this clinically favorable cohort of 12-18 month old patients with","confidence":0.9072265625,"confidence_rate":0.9991152728131285},{"cnt":[[245,973],[1880,973],[1880,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":973,"width":1636,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6438b48d5d84802ac8dddcb8f5c96fd","type":"text","conversion_output":true,"text":"stage 4 disease represents only \\(5 \\%(15 / 313)\\) of all stage 4 patients enrolled onto CCG3891 for whom","text_display":" stage 4 disease represents only \\(5 \\%(15 / 313)\\) of all stage 4 patients enrolled onto CCG3891 for whom","confidence":0.99853515625,"confidence_rate":0.9999867936215969},{"cnt":[[245,1018],[1880,1018],[1880,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1018,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4270279bef946019c55e295eb4986fb","type":"text","conversion_output":true,"text":"MYCN analyses were available and only \\(3 \\%(14 / 528)\\) of all stage D patients enrolled onto POG trials for","text_display":" MYCN analyses were available and only \\(3 \\%(14 / 528)\\) of all stage D patients enrolled onto POG trials for","confidence":0.6991649934207089,"confidence_rate":0.9967221863448849},{"cnt":[[245,1061],[1106,1061],[1106,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1061,"width":863,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd98510c8da8411189f622a4c0531914","type":"text","conversion_output":true,"text":"whom \\(M Y C N\\) and DNA ploidy analyses were available.","text_display":" whom \\(M Y C N\\) and DNA ploidy analyses were available.","confidence":0.7896080017089844,"confidence_rate":0.995864388327269},{"cnt":[[245,1147],[1880,1147],[1880,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1147,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"045381738930475d9cdcb05e4bf4a82a","type":"text","conversion_output":true,"text":"In contrast, patients 12-18 months of age with stage \\(4, M C Y N\\)-NA tumors characterized by either diploid","text_display":"\n\nIn contrast, patients 12-18 months of age with stage \\(4, M C Y N\\)-NA tumors characterized by either diploid","confidence":0.8653497417930567,"confidence_rate":0.9986861227299272},{"cnt":[[245,1195],[1880,1195],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1194,"width":1636,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e3549c8256748e5a943d873018c95d8","type":"text","conversion_output":true,"text":"DNA content (4-year EFS 66.6\\%) or UH tumors (6-year EFS 46\\%) and patients greater than 18 months","text_display":" DNA content (4-year EFS 66.6\\%) or UH tumors (6-year EFS 46\\%) and patients greater than 18 months","confidence":0.9912264347076416,"confidence_rate":0.9999152701318503},{"cnt":[[245,1238],[1880,1238],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1237,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c432ee0c3240481bbbf24488cefb1e91","type":"text","conversion_output":true,"text":"of age with stage 3 tumors and unfavorable histology (5-year EFS 53\\%) have a less favorable outcome","text_display":" of age with stage 3 tumors and unfavorable histology (5-year EFS 53\\%) have a less favorable outcome","confidence":0.92919921875,"confidence_rate":0.999313953952573},{"cnt":[[245,1276],[1880,1276],[1880,1328],[245,1328]],"region":{"top_left_x":244,"top_left_y":1276,"width":1636,"height":52},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23c735f3580f4f4899105498acc99ddc","type":"text","conversion_output":true,"text":"and support further attempts to optimize therapy. \\({ }^{10-12}\\) However, given that the majority of these patients","text_display":" and support further attempts to optimize therapy. \\({ }^{10-12}\\) However, given that the majority of these patients","confidence":1,"confidence_rate":1},{"cnt":[[245,1326],[1880,1326],[1880,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1325,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7809f72ac5ca4e1481f7df3160cb7742","type":"text","conversion_output":true,"text":"treated on legacy CCG or POG trials did not receive myeloablative therapy, a further escalation to tandem","text_display":" treated on legacy CCG or POG trials did not receive myeloablative therapy, a further escalation to tandem","confidence":1,"confidence_rate":1},{"cnt":[[245,1369],[1880,1369],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1368,"width":1636,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c4dab0a4fe7434fbd16596b3d539c6c","type":"text","conversion_output":true,"text":"transplantation may not be warranted. Therefore, patients 12-18 months of age with stage 4 MYCN-NA","text_display":" transplantation may not be warranted. Therefore, patients 12-18 months of age with stage 4 MYCN-NA","confidence":0.5801053047180176,"confidence_rate":0.9948759500186618},{"cnt":[[245,1414],[1880,1414],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc5a45ae9cd742daac4600c6f4ca65e4","type":"text","conversion_output":true,"text":"tumors but with diploid DNA content, UH or indeterminant histology or DNA ploidy and children greater","text_display":" tumors but with diploid DNA content, UH or indeterminant histology or DNA ploidy and children greater","confidence":1,"confidence_rate":1},{"cnt":[[245,1457],[1880,1457],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1456,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2299fbeb21a947ca8d3f83408c86cf51","type":"text","conversion_output":true,"text":"than 18 months of age with stage \\(3 M Y C N\\)-NA tumors with UH, estimated to be \\(1-4 \\%\\) of all high risk","text_display":" than 18 months of age with stage \\(3 M Y C N\\)-NA tumors with UH, estimated to be \\(1-4 \\%\\) of all high risk","confidence":0.8853096961975098,"confidence_rate":0.9988931788335995},{"cnt":[[245,1500],[1880,1500],[1880,1547],[245,1547]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"312927bc9707485f9d4380e30877d268","type":"text","conversion_output":true,"text":"stage patients, will be eligible for treatment on ANBL0532 but will be nonrandomly assigned to single","text_display":" stage patients, will be eligible for treatment on ANBL0532 but will be nonrandomly assigned to single","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1880,1543],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b369ccbfa45c4656a8462b76c6add5cd","type":"text","conversion_output":true,"text":"myeloablative therapy. A uniformed treatment approach will allow improved analysis of outcome for this","text_display":" myeloablative therapy. A uniformed treatment approach will allow improved analysis of outcome for this","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[698,1590],[698,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1589,"width":455,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6173fde2957b42a1a888759b091f3e77","type":"text","conversion_output":true,"text":"relatively rare patient cohort.","text_display":" relatively rare patient cohort.","confidence":1,"confidence_rate":1},{"cnt":[[236,1671],[952,1671],[952,1727],[236,1727]],"region":{"top_left_x":236,"top_left_y":1671,"width":716,"height":57},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85ff6931f1644c2ea2dec92962505193","type":"section_header","conversion_output":false,"children_ids":["144069c0a8ff4c8b9068138f506476ed"],"text":"","text_display":""},{"cnt":[[245,1676],[947,1676],[947,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1675,"width":704,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"144069c0a8ff4c8b9068138f506476ed","type":"text","conversion_output":true,"parent_id":"85ff6931f1644c2ea2dec92962505193","text":"2.2 High-risk Neuroblastoma Therapy","text_display":"\n\n\\subsection*{2.2 High-risk Neuroblastoma Therapy}","confidence":1,"confidence_rate":1},{"cnt":[[245,1719],[1880,1719],[1880,1766],[245,1766]],"region":{"top_left_x":244,"top_left_y":1718,"width":1636,"height":49},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5764f954b234161929d4b9cb0d258d5","type":"text","conversion_output":true,"text":"High-risk neuroblastoma is largely chemotherapy responsive, but despite improvements in complete","text_display":"\n\nHigh-risk neuroblastoma is largely chemotherapy responsive, but despite improvements in complete","confidence":1,"confidence_rate":1},{"cnt":[[245,1766],[1880,1766],[1880,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1766,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ddf9b69913c4aeaa4768d200a8d9867","type":"text","conversion_output":true,"text":"response rates, the majority of patients still relapse. To improve event free survival, COG and legacy","text_display":" response rates, the majority of patients still relapse. To improve event free survival, COG and legacy","confidence":1,"confidence_rate":1},{"cnt":[[245,1809],[1884,1809],[1884,1854],[245,1854]],"region":{"top_left_x":244,"top_left_y":1808,"width":1641,"height":47},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b67a00d14e3c48bf8bf9f58c3469715d","type":"text","conversion_output":true,"text":"CCG and POG clinical trials have intensified chemotherapy during induction and consolidation phases of","text_display":" CCG and POG clinical trials have intensified chemotherapy during induction and consolidation phases of","confidence":0.9990234375,"confidence_rate":0.9999908688300274},{"cnt":[[245,1852],[1880,1852],[1880,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1851,"width":1636,"height":47},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f29c2e0039a4a1a9c06e89f6f3a01ca","type":"text","conversion_output":true,"text":"therapy and added biologic agents for treatment of minimal residual disease. CCG-3891 study","text_display":" therapy and added biologic agents for treatment of minimal residual disease. CCG-3891 study","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,1895],[1880,1895],[1880,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1894,"width":1636,"height":51},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33c0c8fc450f4ba8b804c562f6e3a5f0","type":"text","conversion_output":true,"text":"demonstrated that increased dose intensity of consolidation with purged bone marrow transplant and","text_display":" demonstrated that increased dose intensity of consolidation with purged bone marrow transplant and","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1880,1938],[1880,1985],[245,1985]],"region":{"top_left_x":244,"top_left_y":1937,"width":1636,"height":49},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e351b7b14904477eb41ffea9a63c2de9","type":"text","conversion_output":true,"text":"administration of the biologic agent 13 -cis retinoic acid (cis-RA) following consolidation therapy","text_display":" administration of the biologic agent 13 -cis retinoic acid (cis-RA) following consolidation therapy","confidence":0.73095703125,"confidence_rate":0.9970753076836567},{"cnt":[[245,1981],[1880,1981],[1880,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1980,"width":1636,"height":51},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d90641507c6f44d4a9215dd8741249c6","type":"text","conversion_output":true,"text":"improved outcome for patients with high-risk neuroblastoma \\({ }^{13}\\). The 8 -year EFS and OS rates for patients","text_display":" improved outcome for patients with high-risk neuroblastoma \\({ }^{13}\\). The 8 -year EFS and OS rates for patients","confidence":0.962127685546875,"confidence_rate":0.9996861622015711},{"cnt":[[245,2028],[1880,2028],[1880,2073],[245,2073]],"region":{"top_left_x":244,"top_left_y":2028,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb68fc511fb14cd79926d965c7450417","type":"text","conversion_output":true,"text":"treated with one transplant and cis-RA ( \\(n=50\\) ) are \\(44 \\%+12 \\%\\) and \\(54 \\%+13 \\%\\), respectively (personal","text_display":" treated with one transplant and cis-RA ( \\(n=50\\) ) are \\(44 \\%+12 \\%\\) and \\(54 \\%+13 \\%\\), respectively (personal","confidence":0.8344900459051132,"confidence_rate":0.9983564932736295},{"cnt":[[245,2071],[1878,2071],[1878,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2071,"width":1634,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9952ac74b6734ce0a48f1729784f5ab4","type":"text","conversion_output":true,"text":"communication; K. Matthay and W.London). The recently completed COG Phase III trial, A3973,","text_display":" communication; K. Matthay and W.London). The recently completed COG Phase III trial, A3973,","confidence":1,"confidence_rate":1},{"cnt":[[245,2114],[1880,2114],[1880,2159],[245,2159]],"region":{"top_left_x":244,"top_left_y":2114,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96963c2a2fb14ab79c90eaa681ea645e","type":"text","conversion_output":true,"text":"evaluated whether the use of a more intensive induction chemotherapy regimen (N7), reported by","text_display":" evaluated whether the use of a more intensive induction chemotherapy regimen (N7), reported by","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[245,2153],[1880,2153],[1880,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2152,"width":1636,"height":55},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b5412259bd148d58dfff903ab70000b","type":"text","conversion_output":true,"text":"investigators at Memorial Sloan-Kettering to produce a \\(85 \\%\\) CR/VGPR rate, \\({ }^{14}\\) will result in improved","text_display":" investigators at Memorial Sloan-Kettering to produce a \\(85 \\%\\) CR/VGPR rate, \\({ }^{14}\\) will result in improved","confidence":1,"confidence_rate":1},{"cnt":[[245,2202],[1882,2202],[1882,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2202,"width":1639,"height":48},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a57842540e164552bd48d7b4fb72cb0e","type":"text","conversion_output":true,"text":"EFS and end-induction response rate when compared to CCG-3891. A3973 also tested whether the use of","text_display":" EFS and end-induction response rate when compared to CCG-3891. A3973 also tested whether the use of","confidence":1,"confidence_rate":1},{"cnt":[[245,2247],[1880,2247],[1880,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2247,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b9fc2864ca845ecae3fdc0cd780e467","type":"text","conversion_output":true,"text":"anti-neuroblastoma purged PBSC rescue improves EFS for patients with high-risk neuroblastoma. The","text_display":" anti-neuroblastoma purged PBSC rescue improves EFS for patients with high-risk neuroblastoma. The","confidence":1,"confidence_rate":1},{"cnt":[[245,2290],[1880,2290],[1880,2338],[245,2338]],"region":{"top_left_x":244,"top_left_y":2290,"width":1636,"height":48},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d0b429c896f4047a9d234e3f4c6e552","type":"text","conversion_output":true,"text":"results of COG A3973 indicate no difference in event-free or overall survival with the use of purged","text_display":" results of COG A3973 indicate no difference in event-free or overall survival with the use of purged","confidence":1,"confidence_rate":1},{"cnt":[[245,2333],[1880,2333],[1880,2383],[245,2383]],"region":{"top_left_x":244,"top_left_y":2333,"width":1636,"height":50},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"508e0824fc474e3882c27ce36f920229","type":"text","conversion_output":true,"text":"PBSC products for transplant. Feasibility and toxicity data from COG A3973, ANBL00P1 and ANBL0P2","text_display":" PBSC products for transplant. Feasibility and toxicity data from COG A3973, ANBL00P1 and ANBL0P2","confidence":0.99755859375,"confidence_rate":0.9999757983983905},{"cnt":[[245,2380],[1880,2380],[1880,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2380,"width":1636,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b588b804b88486584979a1e9c59aa6e","type":"text","conversion_output":true,"text":"cited below support the continued utilization of a dose intensive induction regimen and myeloablative","text_display":" cited below support the continued utilization of a dose intensive induction regimen and myeloablative","confidence":1,"confidence_rate":1},{"cnt":[[245,2423],[1880,2423],[1880,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2423,"width":1636,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6bb784f1f5f45569e0541760c9a3983","type":"text","conversion_output":true,"text":"chemotherapy consolidation regimen as the \"backbone\" schema as proposed in this successor study for","text_display":" chemotherapy consolidation regimen as the \"backbone\" schema as proposed in this successor study for","confidence":1,"confidence_rate":1},{"cnt":[[245,2466],[1880,2466],[1880,2512],[245,2512]],"region":{"top_left_x":244,"top_left_y":2466,"width":1636,"height":46},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"463745f3fa04438abd636f06a4734926","type":"text","conversion_output":true,"text":"high-risk neuroblastoma. The current COG ANBL0032 has demonstrated that immunotherapy (ch14.18","text_display":" high-risk neuroblastoma. The current COG ANBL0032 has demonstrated that immunotherapy (ch14.18","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[1880,2509],[1880,2557],[245,2557]],"region":{"top_left_x":244,"top_left_y":2509,"width":1636,"height":48},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c5589fb1725428ab5936a870db2e65d","type":"text","conversion_output":true,"text":"antibody plus cytokines) in addition to cis-RA improves EFS. Patients treated on ANBL0532 will be","text_display":" antibody plus cytokines) in addition to cis-RA improves EFS. Patients treated on ANBL0532 will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2552],[1102,2552],[1102,2602],[245,2602]],"region":{"top_left_x":244,"top_left_y":2552,"width":859,"height":50},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d64e8a05fb9e43fbb3ae4c2726ac5c9c","type":"text","conversion_output":true,"text":"eligible for participation on ANBL0032 or ANBL0931.","text_display":" eligible for participation on ANBL0032 or ANBL0931.","confidence":1,"confidence_rate":1},{"cnt":[[1749,2608],[1878,2608],[1878,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":130,"height":46},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da88a63fbd6e436cb730813f2e875595","type":"page_info","conversion_output":false,"text":"Page 15","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-016","page":16,"lines":[{"cnt":[[245,99],[617,99],[617,165],[245,165]],"region":{"top_left_x":244,"top_left_y":98,"width":373,"height":68},"line":1,"column":0,"font_size":70,"is_printed":true,"is_handwritten":false,"id":"81f8121042cf4f7f8155e5c8ed43b814","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,103],[1652,103],[1652,140],[653,140]],"region":{"top_left_x":653,"top_left_y":103,"width":1000,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"827bdf28b4e84a9ca56ab6dc43607027","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.6461673845629953,"confidence_rate":0.9945561629340698},{"cnt":[[1706,99],[1880,99],[1880,140],[1706,140]],"region":{"top_left_x":1705,"top_left_y":98,"width":175,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c1f5bdd715e4c52a801140932e7a9d2","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,172],[655,172],[655,208],[331,208]],"region":{"top_left_x":330,"top_left_y":171,"width":326,"height":38},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a206ea9759ea44bd869531a24f8c9d8c","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,266],[771,266],[771,320],[241,320]],"region":{"top_left_x":240,"top_left_y":266,"width":532,"height":55},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fff41b9621314ad4811e74cab1b3dee6","type":"section_header","conversion_output":false,"children_ids":["dfa140d39aab48df8bb98e22915749b3"],"text":"","text_display":""},{"cnt":[[245,271],[767,271],[767,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":523,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dfa140d39aab48df8bb98e22915749b3","type":"text","conversion_output":true,"parent_id":"fff41b9621314ad4811e74cab1b3dee6","text":"2.3 Myeloablative regimens","text_display":"\n\n\\subsection*{2.3 Myeloablative regimens}","confidence":1,"confidence_rate":1},{"cnt":[[245,314],[1880,314],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":313,"width":1636,"height":51},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc64167e5ed3445997abed88627cac07","type":"text","conversion_output":true,"text":"The results of the randomized CCG-3891 protocol demonstrate that a myeloablative therapy with","text_display":"\n\nThe results of the randomized CCG-3891 protocol demonstrate that a myeloablative therapy with","confidence":0.9960954189300537,"confidence_rate":0.9999600801453118},{"cnt":[[245,357],[1880,357],[1880,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":1636,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0be4715a149f40ee98910e022af11a7a","type":"text","conversion_output":true,"text":"carboplatin, etoposide, melphalan and 1000 cGy total body irradiation (TBI) and purged autologous bone","text_display":" carboplatin, etoposide, melphalan and 1000 cGy total body irradiation (TBI) and purged autologous bone","confidence":0.8606061935424805,"confidence_rate":0.9986605562331534},{"cnt":[[245,402],[1880,402],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":401,"width":1636,"height":49},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1df84d834764dbe92b7fdbe16c3b832","type":"text","conversion_output":true,"text":"marrow rescue improves EFS for patients with high-risk neuroblastoma. The 3 -year EFS was \\(30 \\%\\) for all","text_display":" marrow rescue improves EFS for patients with high-risk neuroblastoma. The 3 -year EFS was \\(30 \\%\\) for all","confidence":0.7769265174865723,"confidence_rate":0.9977488812805027},{"cnt":[[245,447],[1880,447],[1880,492],[245,492]],"region":{"top_left_x":244,"top_left_y":446,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98a98dbcb1154c8191514f136a4852fd","type":"text","conversion_output":true,"text":"patients on study, \\(85 \\%\\) of which had stage 4 neuroblastoma. The 3-year EFS from time of assigned","text_display":" patients on study, \\(85 \\%\\) of which had stage 4 neuroblastoma. The 3-year EFS from time of assigned","confidence":0.69580078125,"confidence_rate":0.9965842254401989},{"cnt":[[245,490],[1880,490],[1880,535],[245,535]],"region":{"top_left_x":244,"top_left_y":489,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b4736f7cd51471e90c69d44179e0e72","type":"text","conversion_output":true,"text":"randomization was \\(34 \\%\\) for autologous bone marrow transplantation (ABMT) versus \\(22 \\%\\) for","text_display":" randomization was \\(34 \\%\\) for autologous bone marrow transplantation (ABMT) versus \\(22 \\%\\) for","confidence":1,"confidence_rate":1},{"cnt":[[245,529],[1880,529],[1880,580],[245,580]],"region":{"top_left_x":244,"top_left_y":528,"width":1636,"height":53},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27ba484ab834430ca29c97ab07e2068c","type":"text","conversion_output":true,"text":"continuation chemotherapy (CC) ( \\(p =0.045\\) ). \\({ }^{13}\\) Overall survival was not significantly different for the","text_display":" continuation chemotherapy (CC) ( \\(p =0.045\\) ). \\({ }^{13}\\) Overall survival was not significantly different for the","confidence":0.9965865582935293,"confidence_rate":0.999972425535102},{"cnt":[[245,578],[1880,578],[1880,625],[245,625]],"region":{"top_left_x":244,"top_left_y":577,"width":1636,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea9c0849b2e3496cb5179bcd3e02f099","type":"text","conversion_output":true,"text":"two regimens, perhaps partly due to use of ABMT salvage in \\(>30\\) patients who progressed after","text_display":" two regimens, perhaps partly due to use of ABMT salvage in \\(>30\\) patients who progressed after","confidence":0.99755859375,"confidence_rate":0.9999755563853322},{"cnt":[[245,623],[1880,623],[1880,668],[245,668]],"region":{"top_left_x":244,"top_left_y":623,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58344dd2332d43f39acff5715d2a3d82","type":"text","conversion_output":true,"text":"chemotherapy consolidation. An apparent advantage was seen for ABMT within strata separated either by","text_display":" chemotherapy consolidation. An apparent advantage was seen for ABMT within strata separated either by","confidence":1,"confidence_rate":1},{"cnt":[[245,666],[1880,666],[1880,711],[245,711]],"region":{"top_left_x":244,"top_left_y":666,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69c8f80335e2430ab87770a5b9bc78a3","type":"text","conversion_output":true,"text":"MYCN amplification, bone marrow immunocytology or stage. More recent evaluation of outcome for","text_display":" MYCN amplification, bone marrow immunocytology or stage. More recent evaluation of outcome for","confidence":0.89892578125,"confidence_rate":0.9989242678542335},{"cnt":[[245,709],[1880,709],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1636,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0cf68c71730422f894eeb04ab2bad5c","type":"text","conversion_output":true,"text":"those children with high-risk neuroblastoma treated on CCG 3891 revealed an overall 8-year EFS and OS","text_display":" those children with high-risk neuroblastoma treated on CCG 3891 revealed an overall 8-year EFS and OS","confidence":0.66162109375,"confidence_rate":0.9962176093755939},{"cnt":[[245,752],[1880,752],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37eec4d54b4c424d86e5b045f206f95a","type":"text","conversion_output":true,"text":"rate +/- SE from the time of enrollment onto CCG 3891 of \\(24 \\%+/-3 \\%\\) and \\(29 \\%+/-3 \\%( n =539)\\),","text_display":" rate +/- SE from the time of enrollment onto CCG 3891 of \\(24 \\%+/-3 \\%\\) and \\(29 \\%+/-3 \\%( n =539)\\),","confidence":0.944883517222479,"confidence_rate":0.9994550175830069},{"cnt":[[245,797],[1880,797],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":797,"width":1636,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50c9ca56ca1b49a99ec88904c7efbf53","type":"text","conversion_output":true,"text":"respectively, with a median follow-up time of patients who did not experience an event of 7.7 years ( 130","text_display":" respectively, with a median follow-up time of patients who did not experience an event of 7.7 years ( 130","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[1880,842],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":842,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d4e92034ced4d98890b28151af3ea92","type":"text","conversion_output":true,"text":"days -12.8 years) (Table 1). The 8 -year EFS from the time of randomization for patients randomized to","text_display":" days -12.8 years) (Table 1). The 8 -year EFS from the time of randomization for patients randomized to","confidence":0.509480641261749,"confidence_rate":0.9940499541550694},{"cnt":[[245,885],[1880,885],[1880,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1636,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fcd36104c2c34f9d873a5f93c71f8a53","type":"text","conversion_output":true,"text":"ABMT ( \\(n =189\\) ) was \\(27 \\%+/-5 \\%\\) vs. \\(18 \\%+/-4 \\%\\) for patients randomized to CC \\(( n =190), p =0.0434\\). The","text_display":" ABMT ( \\(n =189\\) ) was \\(27 \\%+/-5 \\%\\) vs. \\(18 \\%+/-4 \\%\\) for patients randomized to CC \\(( n =190), p =0.0434\\). The","confidence":0.5735531006718458,"confidence_rate":0.9953394257991756},{"cnt":[[245,928],[1880,928],[1880,975],[245,975]],"region":{"top_left_x":244,"top_left_y":928,"width":1636,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73aa8b180edc4234888ab325601bc0dd","type":"text","conversion_output":true,"text":"8 -year OS for ABMT was not statistically significantly higher than for CC, \\(33 \\%+/-6 \\%\\) vs. \\(25 \\%+/-4 \\%\\),","text_display":" 8 -year OS for ABMT was not statistically significantly higher than for CC, \\(33 \\%+/-6 \\%\\) vs. \\(25 \\%+/-4 \\%\\),","confidence":0.9343558561949976,"confidence_rate":0.9993772773579076},{"cnt":[[245,971],[1880,971],[1880,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":971,"width":1636,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"222e13539912485989fdadbae095b7a0","type":"text","conversion_output":true,"text":"\\(p =0.3917\\) (personal communication, K. Matthay and W. London). These data continue to suggest that","text_display":" \\(p =0.3917\\) (personal communication, K. Matthay and W. London). These data continue to suggest that","confidence":0.9951171875,"confidence_rate":0.9999524790672453},{"cnt":[[245,1018],[1880,1018],[1880,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1018,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dac4d66e8ff04daab198175aacf4f171","type":"text","conversion_output":true,"text":"therapy intensification diminishes risks for neuroblastoma recurrence. Based on the incremental","text_display":" therapy intensification diminishes risks for neuroblastoma recurrence. Based on the incremental","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1880,1061],[1880,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cebeab78ca434502bc4653c12a79c8a1","type":"text","conversion_output":true,"text":"improvement in EFS with ABMT, myeloablative consolidation has become a standard of care for patients","text_display":" improvement in EFS with ABMT, myeloablative consolidation has become a standard of care for patients","confidence":1,"confidence_rate":1},{"cnt":[[245,1104],[1085,1104],[1085,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1104,"width":841,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79517576897741c3ab94452afd833e78","type":"text","conversion_output":true,"text":"with high-risk disease in the United States and abroad.","text_display":" with high-risk disease in the United States and abroad.","confidence":1,"confidence_rate":1},{"cnt":[[245,1188],[1880,1188],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1188,"width":1636,"height":52},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da7d1851a40a415bb0b782406b49462d","type":"text","conversion_output":true,"text":"While TBI was used in the initial studies of autologous transplantation for neuroblastoma \\({ }^{15}\\), the","text_display":"\n\nWhile TBI was used in the initial studies of autologous transplantation for neuroblastoma \\({ }^{15}\\), the","confidence":1,"confidence_rate":1},{"cnt":[[245,1233],[1880,1233],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1233,"width":1636,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71e849eff0044986bf4bdec9f3f53233","type":"text","conversion_output":true,"text":"worldwide trend has been to eliminate this modality due to excessive toxicity including second","text_display":" worldwide trend has been to eliminate this modality due to excessive toxicity including second","confidence":1,"confidence_rate":1},{"cnt":[[245,1276],[1880,1276],[1880,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1276,"width":1636,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad6e8e9ea2224a85b532e304145a27dc","type":"text","conversion_output":true,"text":"malignancies. \\({ }^{16}\\) It is now clear that retrospective comparisons of TBI and non-TBI containing regimens","text_display":" malignancies. \\({ }^{16}\\) It is now clear that retrospective comparisons of TBI and non-TBI containing regimens","confidence":1,"confidence_rate":1},{"cnt":[[245,1319],[1880,1319],[1880,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1319,"width":1636,"height":52},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fae0fc02ab30486a9ab7f44d22205c7c","type":"text","conversion_output":true,"text":"showed no difference in patient outcomes. \\({ }^{16}\\) Smedler et al. reported a moderate general developmental","text_display":" showed no difference in patient outcomes. \\({ }^{16}\\) Smedler et al. reported a moderate general developmental","confidence":0.9448771476745605,"confidence_rate":0.9995113232138262},{"cnt":[[245,1366],[1880,1366],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1366,"width":1636,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c03b9a7cb8184b968c18d0a402cc2004","type":"text","conversion_output":true,"text":"delay; with motor, perceptual and cognitive defects in ten children transplanted for leukemia or","text_display":" delay; with motor, perceptual and cognitive defects in ten children transplanted for leukemia or","confidence":1,"confidence_rate":1},{"cnt":[[245,1405],[1880,1405],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":54},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a2c6ba633b1423ab3530b092116032e","type":"text","conversion_output":true,"text":"neuroblastoma with TBI regimens. \\({ }^{18}\\) Children transplanted for neuroblastoma with TBI also demonstrate","text_display":" neuroblastoma with TBI regimens. \\({ }^{18}\\) Children transplanted for neuroblastoma with TBI also demonstrate","confidence":1,"confidence_rate":1},{"cnt":[[245,1450],[1880,1450],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1450,"width":1636,"height":52},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d2e42939b394967999974e32001546c","type":"text","conversion_output":true,"text":"abnormal growth rates, in some cases associated with growth hormone deficiency. \\({ }^{19}\\) TBI regimens can","text_display":" abnormal growth rates, in some cases associated with growth hormone deficiency. \\({ }^{19}\\) TBI regimens can","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1545],[245,1545]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f80c77b4954f494fa60c61e7d7b1cef3","type":"text","conversion_output":true,"text":"also cause late effects such as cataracts, other endocrine dysfunction, and secondary malignant","text_display":" also cause late effects such as cataracts, other endocrine dysfunction, and secondary malignant","confidence":1,"confidence_rate":1},{"cnt":[[245,1538],[1880,1538],[1880,1590],[245,1590]],"region":{"top_left_x":244,"top_left_y":1538,"width":1636,"height":52},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbe4865af6524d70b49ea1e3f9dbcb56","type":"text","conversion_output":true,"text":"neoplasms. \\({ }^{20}\\) There has been no prospective comparative trial to determine whether the addition of TBI","text_display":" neoplasms. \\({ }^{20}\\) There has been no prospective comparative trial to determine whether the addition of TBI","confidence":1,"confidence_rate":1},{"cnt":[[245,1588],[1880,1588],[1880,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1587,"width":1636,"height":48},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ce8ee3af7224ba694091d03f819398c","type":"text","conversion_output":true,"text":"improves survival from high-risk neuroblastoma. A retrospective review of 51 patients transplanted for","text_display":" improves survival from high-risk neuroblastoma. A retrospective review of 51 patients transplanted for","confidence":1,"confidence_rate":1},{"cnt":[[245,1633],[1880,1633],[1880,1678],[245,1678]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56414415e91440ec9cc6d24174800048","type":"text","conversion_output":true,"text":"advanced or poorly responding neuroblastoma from the European BMT Solid Tumor Registry found no","text_display":" advanced or poorly responding neuroblastoma from the European BMT Solid Tumor Registry found no","confidence":1,"confidence_rate":1},{"cnt":[[245,1671],[1880,1671],[1880,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1671,"width":1636,"height":50},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9daae4e738844d419ab3799a4ed2ee40","type":"text","conversion_output":true,"text":"significant difference in outcome between TBI and non-TBI regimens. \\({ }^{17}\\) A separate retrospective review","text_display":" significant difference in outcome between TBI and non-TBI regimens. \\({ }^{17}\\) A separate retrospective review","confidence":1,"confidence_rate":1},{"cnt":[[245,1719],[1880,1719],[1880,1764],[245,1764]],"region":{"top_left_x":244,"top_left_y":1718,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be2ebc8d04824e6896e56aa01c3703ed","type":"text","conversion_output":true,"text":"of 62 concurrently treated stage 4 neuroblastoma patients with and without TBI also demonstrated","text_display":" of 62 concurrently treated stage 4 neuroblastoma patients with and without TBI also demonstrated","confidence":1,"confidence_rate":1},{"cnt":[[245,1762],[1880,1762],[1880,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1761,"width":1636,"height":51},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf6a7b47c6554713a4463e0d54a1a366","type":"text","conversion_output":true,"text":"equivalent survival rates. \\({ }^{16}\\) The CHLA group has shown a 3-year EFS rate of \\(49 \\%+/-6 \\%\\) in 73 patients","text_display":" equivalent survival rates. \\({ }^{16}\\) The CHLA group has shown a 3-year EFS rate of \\(49 \\%+/-6 \\%\\) in 73 patients","confidence":0.5888671875,"confidence_rate":0.9955967677049865},{"cnt":[[245,1807],[1880,1807],[1880,1854],[245,1854]],"region":{"top_left_x":244,"top_left_y":1806,"width":1636,"height":49},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d59c9d70c5d4999af3aa9f738adff47","type":"text","conversion_output":true,"text":"analyzed from the end of induction therapy who were treated on protocol 91-LA6 with a non-TBI","text_display":" analyzed from the end of induction therapy who were treated on protocol 91-LA6 with a non-TBI","confidence":1,"confidence_rate":1},{"cnt":[[245,1852],[1880,1852],[1880,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1851,"width":1636,"height":47},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9684ef2a34b40959760f7771545c24a","type":"text","conversion_output":true,"text":"regimen of carboplatin, etoposide and melphalan with local irradiation (CEM-LI, Table 1). A preliminary","text_display":" regimen of carboplatin, etoposide and melphalan with local irradiation (CEM-LI, Table 1). A preliminary","confidence":1,"confidence_rate":1},{"cnt":[[245,1895],[1880,1895],[1880,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1894,"width":1636,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0902297eefb04c67bee55e5b5edd2648","type":"text","conversion_output":true,"text":"comparison of the EFS of patients with stage 4 neuroblastoma over one year of age at diagnosis","text_display":" comparison of the EFS of patients with stage 4 neuroblastoma over one year of age at diagnosis","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1880,1938],[1880,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1937,"width":1636,"height":51},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"066092ce7d344be69100f0b1f68143e6","type":"text","conversion_output":true,"text":"transplanted before progression with CEM-LI ( \\(n =47\\) ) with the same cohort of patients treated with CEM-","text_display":" transplanted before progression with CEM-LI ( \\(n =47\\) ) with the same cohort of patients treated with CEM","confidence":0.84210205078125,"confidence_rate":0.9984936438386791},{"cnt":[[245,1985],[1880,1985],[1880,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1985,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b563a5b679f7495590760ea66771b995","type":"text","conversion_output":true,"text":"TBI on CCG-321P3 ( \\(n =43\\) ) showed no significant difference in outcome ( \\(p =0.059\\) ). Overall, there were","text_display":"TBI on CCG-321P3 ( \\(n =43\\) ) showed no significant difference in outcome ( \\(p =0.059\\) ). Overall, there were","confidence":0.9795112609863281,"confidence_rate":0.9998260525676209},{"cnt":[[245,2028],[1880,2028],[1880,2073],[245,2073]],"region":{"top_left_x":244,"top_left_y":2028,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"baa359af4cf7489c9812f234de91d28d","type":"text","conversion_output":true,"text":"4/73 (5\\%) toxic deaths in the patients transplanted before progression with CEM on the 91-LA6 protocol","text_display":" 4/73 (5\\%) toxic deaths in the patients transplanted before progression with CEM on the 91-LA6 protocol","confidence":0.9858527183532715,"confidence_rate":0.9998668471048524},{"cnt":[[245,2071],[1878,2071],[1878,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2071,"width":1634,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2fcc0434e3b4fac83b5e2a3f0a0adcb","type":"text","conversion_output":true,"text":"as compared to \\(8.3 \\%\\) toxic deaths following CEM-TBI in similar patients transplanted on CCG-321P3.","text_display":" as compared to \\(8.3 \\%\\) toxic deaths following CEM-TBI in similar patients transplanted on CCG-321P3.","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,2114],[1880,2114],[1880,2161],[245,2161]],"region":{"top_left_x":244,"top_left_y":2114,"width":1636,"height":48},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45fb6e97c2db492ba247d59ddf55a96c","type":"text","conversion_output":true,"text":"These data suggest that the proposed CEM-LI without TBI is at least as effective as prior TBI regimens","text_display":" These data suggest that the proposed CEM-LI without TBI is at least as effective as prior TBI regimens","confidence":1,"confidence_rate":1},{"cnt":[[245,2157],[1880,2157],[1880,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2157,"width":1636,"height":50},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cdd9050664c0409d9c05ef0df779bc22","type":"text","conversion_output":true,"text":"with the caveats that sample size limited the ability to detect a statistical difference in EFS and that trend","text_display":" with the caveats that sample size limited the ability to detect a statistical difference in EFS and that trend","confidence":1,"confidence_rate":1},{"cnt":[[245,2202],[1880,2202],[1880,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2202,"width":1636,"height":48},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"022060dad95640c0b0f24b97e3321c9e","type":"text","conversion_output":true,"text":"towards improvement in EFS in this historical comparison could also be attributed to general","text_display":" towards improvement in EFS in this historical comparison could also be attributed to general","confidence":1,"confidence_rate":1},{"cnt":[[245,2247],[1880,2247],[1880,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2247,"width":1636,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a54ae6242dd0448d84f40c6864ea9d07","type":"text","conversion_output":true,"text":"improvements in care and induction regimens used in the 91-LA-6 (personal communication, J.","text_display":" improvements in care and induction regimens used in the 91-LA-6 (personal communication, J.","confidence":1,"confidence_rate":1},{"cnt":[[245,2290],[449,2290],[449,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2290,"width":206,"height":50},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8287047e858941389a878ebdb8b5f3df","type":"text","conversion_output":true,"text":"Villablanca).","text_display":" Villablanca).","confidence":1,"confidence_rate":1},{"cnt":[[245,2376],[1880,2376],[1880,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2376,"width":1636,"height":50},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6455829c8fa4d2cadee61ed45e18737","type":"text","conversion_output":true,"text":"The COG A3973 recently completed Phase III trial utilized the CEM preparative regimen based upon the","text_display":"\n\nThe COG A3973 recently completed Phase III trial utilized the CEM preparative regimen based upon the","confidence":1,"confidence_rate":1},{"cnt":[[245,2423],[1880,2423],[1880,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2423,"width":1636,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d385a5e71784e669ab1e848ae15533d","type":"text","conversion_output":true,"text":"results for the 91LA6 clinical trial noted above. Of the 489 eligible patients enrolled onto A3973, 368 had","text_display":" results for the 91LA6 clinical trial noted above. Of the 489 eligible patients enrolled onto A3973, 368 had","confidence":1,"confidence_rate":1},{"cnt":[[245,2466],[1880,2466],[1880,2514],[245,2514]],"region":{"top_left_x":244,"top_left_y":2466,"width":1636,"height":48},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c564ba1406e844cf88675ee0cb47747e","type":"text","conversion_output":true,"text":"completed preparative regimen of carboplatin, etoposide, melphalan and autologous transplant with either","text_display":" completed preparative regimen of carboplatin, etoposide, melphalan and autologous transplant with either","confidence":1,"confidence_rate":1},{"cnt":[[245,2509],[1880,2509],[1880,2557],[245,2557]],"region":{"top_left_x":244,"top_left_y":2509,"width":1636,"height":48},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b91295feb5b24cfca88e26d8510ca6ea","type":"text","conversion_output":true,"text":"purged or unpurged PBSC and reported on toxicity. Nearly \\(75 \\%\\) of the patients developed Grade 3 or 4","text_display":" purged or unpurged PBSC and reported on toxicity. Nearly \\(75 \\%\\) of the patients developed Grade 3 or 4","confidence":0.9677734375,"confidence_rate":0.9996995197287515},{"cnt":[[245,2552],[1880,2552],[1880,2602],[245,2602]],"region":{"top_left_x":244,"top_left_y":2552,"width":1636,"height":50},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cdd090b3c404f749fdb514b9ce732a2","type":"text","conversion_output":true,"text":"stomatitis during consolidation. One patient developed Grade 3 cardiac dysfunction, and four had renal","text_display":" stomatitis during consolidation. One patient developed Grade 3 cardiac dysfunction, and four had renal","confidence":1,"confidence_rate":1},{"cnt":[[1749,2608],[1880,2608],[1880,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":132,"height":46},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e99aa3f01b74c2299f60c71be02526b","type":"page_info","conversion_output":false,"text":"Page 16","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-017","page":17,"lines":[{"cnt":[[245,99],[617,99],[617,165],[245,165]],"region":{"top_left_x":244,"top_left_y":98,"width":373,"height":68},"line":1,"column":0,"font_size":70,"is_printed":true,"is_handwritten":false,"id":"e242c15718ca4e55a4154435646c3ff3","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,103],[1652,103],[1652,140],[653,140]],"region":{"top_left_x":653,"top_left_y":103,"width":1000,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a3eb249e21b240adab7cf6bad21e460e","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.6495842508738455,"confidence_rate":0.9946217307722369},{"cnt":[[1706,99],[1880,99],[1880,140],[1706,140]],"region":{"top_left_x":1705,"top_left_y":98,"width":175,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dec85cca6de249bc896ead5362e703d8","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[329,172],[655,172],[655,208],[329,208]],"region":{"top_left_x":328,"top_left_y":171,"width":328,"height":38},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"dc2eec7976b249deb3e189b225c6389f","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,228],[1880,228],[1880,273],[245,273]],"region":{"top_left_x":244,"top_left_y":227,"width":1636,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3fb00a45f6a4bcba9ad75cfcb5a85f8","type":"text","conversion_output":true,"text":"dysfunction. Three patients developed renal failure requiring dialysis. Two of these patients had severe","text_display":"\ndysfunction. Three patients developed renal failure requiring dialysis. Two of these patients had severe","confidence":1,"confidence_rate":1},{"cnt":[[245,271],[1880,271],[1880,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20f22c8d8cbc4458b50656681480ab50","type":"text","conversion_output":true,"text":"sinusoidal-obstruction syndrome (SOS), formerly VOD, the other had severe capillary leak syndrome","text_display":" sinusoidal-obstruction syndrome (SOS), formerly VOD, the other had severe capillary leak syndrome","confidence":1,"confidence_rate":1},{"cnt":[[245,316],[1880,316],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":315,"width":1636,"height":49},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2df3df95eb274be8975d94403d955e14","type":"text","conversion_output":true,"text":"with grade 2 elevation of bilirubin, but no hepatic enlargement. All 3 patients proceeded to post transplant","text_display":" with grade 2 elevation of bilirubin, but no hepatic enlargement. All 3 patients proceeded to post transplant","confidence":1,"confidence_rate":1},{"cnt":[[245,361],[1880,361],[1880,406],[245,406]],"region":{"top_left_x":244,"top_left_y":360,"width":1636,"height":47},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"872b24c65a6248bd8d5b37223f2a72bc","type":"text","conversion_output":true,"text":"therapy on study. In total, 12 of 368 ( \\(3.2 \\%\\) ) patients have died of complications during Consolidation","text_display":" therapy on study. In total, 12 of 368 ( \\(3.2 \\%\\) ) patients have died of complications during Consolidation","confidence":0.4208376262395177,"confidence_rate":0.9926297881725937},{"cnt":[[245,404],[1880,404],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":403,"width":1636,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a277d9eeb8445649d6099215878931f","type":"text","conversion_output":true,"text":"phase of therapy, mainly due to infectious complications ( \\(n =8\\) ). There have been 20 patients reported","text_display":" phase of therapy, mainly due to infectious complications ( \\(n =8\\) ). There have been 20 patients reported","confidence":0.9285947307944298,"confidence_rate":0.9993615583926386},{"cnt":[[245,447],[1880,447],[1880,492],[245,492]],"region":{"top_left_x":244,"top_left_y":446,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5137d713965e40e793b351d4968a6db2","type":"text","conversion_output":true,"text":"with SOS, which resulted in death in the 3 patients. These toxicities are similar to those reported using","text_display":" with SOS, which resulted in death in the 3 patients. These toxicities are similar to those reported using","confidence":1,"confidence_rate":1},{"cnt":[[245,486],[1880,486],[1880,535],[245,535]],"region":{"top_left_x":244,"top_left_y":485,"width":1636,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3aee430ffd840b785731cd1c162d59f","type":"text","conversion_output":true,"text":"alternative myeloablative consolidation regimens \\({ }^{13,21-23}\\) and did not meet designed stopping rules. Two-","text_display":" alternative myeloablative consolidation regimens \\({ }^{13,21-23}\\) and did not meet designed stopping rules. Two","confidence":0.9970703125,"confidence_rate":0.999975344947346},{"cnt":[[245,535],[1880,535],[1880,580],[245,580]],"region":{"top_left_x":244,"top_left_y":534,"width":1636,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61a7b874e5fe4d39b57b3bec94c030f9","type":"text","conversion_output":true,"text":"year EFS for the tranpslanted cohort from time of study enrollment was \\(48+/-3 \\%\\). The 91LA6 and COG","text_display":"year EFS for the tranpslanted cohort from time of study enrollment was \\(48+/-3 \\%\\). The 91LA6 and COG","confidence":0.99560546875,"confidence_rate":0.9999584516595247},{"cnt":[[245,580],[1878,580],[1878,625],[245,625]],"region":{"top_left_x":244,"top_left_y":580,"width":1634,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1aadde398ca4018b1510e2bfffed53c","type":"text","conversion_output":true,"text":"A3973 experience to date suggest tolerable toxicity following CEM-LI consolidation therapy.","text_display":" A3973 experience to date suggest tolerable toxicity following CEM-LI consolidation therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,623],[1880,623],[1880,668],[245,668]],"region":{"top_left_x":244,"top_left_y":623,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a5304ca3dbd40a2b5c5e004fc90a11d","type":"text","conversion_output":true,"text":"Comparative analysis of 91LA6, CCG 321-P3 and A3973 indicates that the CEM-LI regimen without","text_display":" Comparative analysis of 91LA6, CCG 321-P3 and A3973 indicates that the CEM-LI regimen without","confidence":1,"confidence_rate":1},{"cnt":[[245,666],[1884,666],[1884,711],[245,711]],"region":{"top_left_x":244,"top_left_y":666,"width":1641,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64b9bddd2a5b4f9abe99a3f46dbc64a9","type":"text","conversion_output":true,"text":"TBI is at least as effective as prior TBI regimens. Therefore, CEM-LI will be employed in each arm of","text_display":" TBI is at least as effective as prior TBI regimens. Therefore, CEM-LI will be employed in each arm of","confidence":1,"confidence_rate":1},{"cnt":[[245,709],[1555,709],[1555,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1312,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"096c3b5af4554fc2b124a5f0f113acaf","type":"text","conversion_output":true,"text":"this successor Phase III study comparing single versus tandem consolidation therapy.","text_display":" this successor Phase III study comparing single versus tandem consolidation therapy.","confidence":1,"confidence_rate":1},{"cnt":[[241,793],[930,793],[930,849],[241,849]],"region":{"top_left_x":240,"top_left_y":792,"width":691,"height":57},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11db1122e3df4f6facba68cbecc1e71b","type":"section_header","conversion_output":false,"children_ids":["793626e7e8924b80afb0568715a3030d"],"text":"","text_display":""},{"cnt":[[245,799],[924,799],[924,844],[245,844]],"region":{"top_left_x":244,"top_left_y":799,"width":680,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"793626e7e8924b80afb0568715a3030d","type":"text","conversion_output":true,"parent_id":"11db1122e3df4f6facba68cbecc1e71b","text":"2.4 Tandem Myeloablative Regimens","text_display":"\n\n\\subsection*{2.4 Tandem Myeloablative Regimens}","confidence":1,"confidence_rate":1},{"cnt":[[245,836],[1880,836],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":835,"width":1636,"height":53},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db9ece5b274f44a7af728a08a569e817","type":"text","conversion_output":true,"text":"High-risk neuroblastoma remains incurable in \\(60-70 \\%\\) of patients. \\({ }^{6,13}\\) Further dose intensity may yield","text_display":"\n\nHigh-risk neuroblastoma remains incurable in \\(60-70 \\%\\) of patients. \\({ }^{6,13}\\) Further dose intensity may yield","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1880,885],[1880,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1636,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f99dc9e9c5b40e788de610311cfdbac","type":"text","conversion_output":true,"text":"further improvements in EFS. To achieve this, tandem, or dual-cycle, transplant approaches have been","text_display":" further improvements in EFS. To achieve this, tandem, or dual-cycle, transplant approaches have been","confidence":1,"confidence_rate":1},{"cnt":[[245,928],[1880,928],[1880,975],[245,975]],"region":{"top_left_x":244,"top_left_y":928,"width":1636,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3526f29ff67f4b1abd34b1a310d27a93","type":"text","conversion_output":true,"text":"developed. An initial attempt at tandem transplant using marrow support was piloted by the European","text_display":" developed. An initial attempt at tandem transplant using marrow support was piloted by the European","confidence":1,"confidence_rate":1},{"cnt":[[245,971],[1880,971],[1880,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":971,"width":1636,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75363c67bfd14e93b22002889b8822b6","type":"text","conversion_output":true,"text":"Neuroblastoma Group in the LMCE2. \\({ }^{24}\\) Median time to reach the second ABMT was 3 mos. (range 2-6","text_display":" Neuroblastoma Group in the LMCE2. \\({ }^{24}\\) Median time to reach the second ABMT was 3 mos. (range 2-6","confidence":0.92724609375,"confidence_rate":0.999331760757667},{"cnt":[[245,1018],[1880,1018],[1880,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1018,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45e5b5fb21c047e6979afe707ca402c3","type":"text","conversion_output":true,"text":"mos.), and median time to ANC \\(>500\\) was 43 days (15-120). Overall survival at 2 years was \\(36 \\%\\) in a","text_display":" mos.), and median time to ANC \\(>500\\) was 43 days (15-120). Overall survival at 2 years was \\(36 \\%\\) in a","confidence":0.7848076553829628,"confidence_rate":0.9978766731019203},{"cnt":[[245,1061],[1377,1061],[1377,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1061,"width":1134,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"caa12f46b14b47f59b4d701b0fdadc4f","type":"text","conversion_output":true,"text":"very high-risk group of patients, but the toxic death rate was high at \\(24 \\%\\).","text_display":" very high-risk group of patients, but the toxic death rate was high at \\(24 \\%\\).","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1880,1147],[1880,1195],[245,1195]],"region":{"top_left_x":244,"top_left_y":1147,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"caa5650faa9f4dae9525b0a622cfd50a","type":"text","conversion_output":true,"text":"Grupp et al. explored the use of tandem transplant with PBSC support in children with high-risk solid","text_display":"\n\nGrupp et al. explored the use of tandem transplant with PBSC support in children with high-risk solid","confidence":1,"confidence_rate":1},{"cnt":[[245,1190],[1880,1190],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1190,"width":1636,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff131c0d8dc34f268f9e96723fd44def","type":"text","conversion_output":true,"text":"tumors. \\({ }^{25,26}\\) The myeloablative regimens employed in the CHP-594/DFCI 34-DAT study were an initial","text_display":" tumors. \\({ }^{25,26}\\) The myeloablative regimens employed in the CHP-594/DFCI 34-DAT study were an initial","confidence":1,"confidence_rate":1},{"cnt":[[245,1233],[1880,1233],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1233,"width":1636,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f93769bfdf5141f3a340f78f305ebe27","type":"text","conversion_output":true,"text":"regimen of \\(2.4 g / m ^{2}\\) etoposide, \\(3.6 g / m ^{2}\\) cyclophosphamide and carboplatin \\(2 g / m ^{2}\\) followed 4-6 weeks","text_display":" regimen of \\(2.4 g / m ^{2}\\) etoposide, \\(3.6 g / m ^{2}\\) cyclophosphamide and carboplatin \\(2 g / m ^{2}\\) followed 4-6 weeks","confidence":0.9501953125,"confidence_rate":0.9996548722499274},{"cnt":[[245,1278],[1880,1278],[1880,1328],[245,1328]],"region":{"top_left_x":244,"top_left_y":1278,"width":1636,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b858ea89fd64318896869948e93ea6c","type":"text","conversion_output":true,"text":"later by a second regimen of melphalan \\(180 mg / m ^{2}\\) with 12 Gy of TBI. Initial data on 55 enrolled patients","text_display":" later by a second regimen of melphalan \\(180 mg / m ^{2}\\) with 12 Gy of TBI. Initial data on 55 enrolled patients","confidence":0.9663405418395996,"confidence_rate":0.9997366579182403},{"cnt":[[245,1326],[1880,1326],[1880,1373],[245,1373]],"region":{"top_left_x":244,"top_left_y":1325,"width":1636,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf6e307772794613b44881f5c0a800c2","type":"text","conversion_output":true,"text":"(ages 1 to 18 years) demonstrated the feasibility of the approach with 98 cycles of myeloablative therapy","text_display":" (ages 1 to 18 years) demonstrated the feasibility of the approach with 98 cycles of myeloablative therapy","confidence":1,"confidence_rate":1},{"cnt":[[245,1371],[1880,1371],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1370,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb3171c1b3114278bdb2d9acaf1afeaa","type":"text","conversion_output":true,"text":"with stem cell rescue completed. Four patients who completed the first HSCT course did not complete the","text_display":" with stem cell rescue completed. Four patients who completed the first HSCT course did not complete the","confidence":1,"confidence_rate":1},{"cnt":[[245,1414],[1880,1414],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"382d5bef5550436f93ee532270ce62ea","type":"text","conversion_output":true,"text":"second, and there were three toxic deaths. Median time to neutrophil engraftment was 11 days. One","text_display":" second, and there were three toxic deaths. Median time to neutrophil engraftment was 11 days. One","confidence":1,"confidence_rate":1},{"cnt":[[245,1457],[1880,1457],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1456,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1925281d4ffe42109057dec001d2f4cf","type":"text","conversion_output":true,"text":"patient experienced delayed engraftment but recovered following infusion of back-up PBSC. The 3-year","text_display":" patient experienced delayed engraftment but recovered following infusion of back-up PBSC. The 3-year","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,1500],[1880,1500],[1880,1547],[245,1547]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8357994a90848de98ee3b63897883fc","type":"text","conversion_output":true,"text":"EFS was \\(58 \\%\\) with a median follow-up of 22 months from diagnosis. These data are substantiated by a","text_display":" EFS was \\(58 \\%\\) with a median follow-up of 22 months from diagnosis. These data are substantiated by a","confidence":0.99853515625,"confidence_rate":0.9999865513043565},{"cnt":[[245,1543],[1880,1543],[1880,1590],[245,1590]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":48},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ad6a8b8dc9d48a99a66a7b43a1c3de2","type":"text","conversion_output":true,"text":"more recent analysis of 97 consecutive children (including the 55 previously published) treated with the","text_display":" more recent analysis of 97 consecutive children (including the 55 previously published) treated with the","confidence":1,"confidence_rate":1},{"cnt":[[245,1588],[1880,1588],[1880,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1587,"width":1636,"height":48},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ca95c429e044702bd1fec26c1e18df3","type":"text","conversion_output":true,"text":"CHP-594/DFCI 34-DAT that shows a 3 -year PFS and OS of \\(55 \\%(95 \\% CI , 40-65 \\%)\\) and \\(66 \\%(95 \\% CI\\)","text_display":" CHP-594/DFCI 34-DAT that shows a 3 -year PFS and OS of \\(55 \\%(95 \\% CI , 40-65 \\%)\\) and \\(66 \\%(95 \\% CI","confidence":0.6111081475493222,"confidence_rate":0.995183388876303},{"cnt":[[245,1633],[1880,1633],[1880,1678],[245,1678]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f92558acaef4c4eb2452126460e9644","type":"text","conversion_output":true,"text":"\\(35-60 \\%\\) ), respectively; a 5 -year PFS and OS of \\(47 \\%\\) ( \\(95 \\%\\) CI \\(35-60 \\%\\) ) and \\(55 \\%\\) ( \\(95 \\%\\) CI \\(43-68 \\%\\) ),","text_display":" 35-60 \\%\\) ), respectively; a 5 -year PFS and OS of \\(47 \\%\\) ( \\(95 \\%\\) CI \\(35-60 \\%\\) ) and \\(55 \\%\\) ( \\(95 \\%\\) CI \\(43-68 \\%\\) ),","confidence":0.5753275342799592,"confidence_rate":0.995441695332522},{"cnt":[[245,1671],[1880,1671],[1880,1723],[245,1723]],"region":{"top_left_x":244,"top_left_y":1671,"width":1636,"height":53},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc61806f4e3648ea8887ef6c7a126418","type":"text","conversion_output":true,"text":"respectively and a 7 -year PFS of \\(45 \\% .^{27}\\) Of the 89 patients who received at least one HSCT, the 5 -year","text_display":" respectively and a 7 -year PFS of \\(45 \\% .^{27}\\) Of the 89 patients who received at least one HSCT, the 5 -year","confidence":0.8285878227325156,"confidence_rate":0.9985205250655601},{"cnt":[[245,1719],[1145,1719],[1145,1768],[245,1768]],"region":{"top_left_x":244,"top_left_y":1718,"width":902,"height":51},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afdc09f899184369a43251c44ba280f9","type":"text","conversion_output":true,"text":"and 7 -year PFS was \\(51 \\%\\) and \\(49 \\%\\), respectively (Table 1).","text_display":" and 7 -year PFS was \\(51 \\%\\) and \\(49 \\%\\), respectively (Table 1).","confidence":0.924285888671875,"confidence_rate":0.9988916871417305},{"cnt":[[245,1813],[1880,1813],[1880,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1813,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b18321965f14679a3ecbe6183737382","type":"text","conversion_output":true,"text":"Toxicity and feasibility data on tandem transplantation without TBI have been evaluated in POG 9640","text_display":"\n\nToxicity and feasibility data on tandem transplantation without TBI have been evaluated in POG 9640","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,1856],[1880,1856],[1880,1901],[245,1901]],"region":{"top_left_x":244,"top_left_y":1856,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85dfc2c08d8c41b48c23ef027943319d","type":"text","conversion_output":true,"text":"and COG ANBL00P1 studies. POG 9640 enrolled 33 patients and utilized 5 cycles of induction","text_display":" and COG ANBL00P1 studies. POG 9640 enrolled 33 patients and utilized 5 cycles of induction","confidence":1,"confidence_rate":1},{"cnt":[[245,1899],[1880,1899],[1880,1949],[245,1949]],"region":{"top_left_x":244,"top_left_y":1899,"width":1636,"height":50},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8dfe6b8970b4fc799cecbe30d474165","type":"text","conversion_output":true,"text":"chemotherapy followed by tandem transplantation with unpurged PBSC support. The tandem regimens","text_display":" chemotherapy followed by tandem transplantation with unpurged PBSC support. The tandem regimens","confidence":1,"confidence_rate":1},{"cnt":[[245,1944],[1880,1944],[1880,1992],[245,1992]],"region":{"top_left_x":244,"top_left_y":1944,"width":1636,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"028733aa7fef4c199a152aa073ea0184","type":"text","conversion_output":true,"text":"were: Carboplatin, etoposide, cyclophosphamide (AT\\#1) followed by thiotepa and cyclophosphamide","text_display":" were: Carboplatin, etoposide, cyclophosphamide (AT\\#1) followed by thiotepa and cyclophosphamide","confidence":1,"confidence_rate":1},{"cnt":[[245,1987],[1880,1987],[1880,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1987,"width":1636,"height":48},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a61185762f654472a914ae9ccfbf808f","type":"text","conversion_output":true,"text":"(AT\\#2). This regimen was found to be feasible and tolerable. There were no toxic deaths associated with","text_display":" (AT\\#2). This regimen was found to be feasible and tolerable. There were no toxic deaths associated with","confidence":1,"confidence_rate":1},{"cnt":[[245,2032],[1880,2032],[1880,2078],[245,2078]],"region":{"top_left_x":244,"top_left_y":2032,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cbceab270a7463480a982fd5a21eec3","type":"text","conversion_output":true,"text":"the tandem regimen. A total of 21 patients underwent at least one course myeloablative therapy and 17","text_display":" the tandem regimen. A total of 21 patients underwent at least one course myeloablative therapy and 17","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,2075],[1880,2075],[1880,2121],[245,2121]],"region":{"top_left_x":244,"top_left_y":2075,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"633fdaecec8a45a8832caa534212143c","type":"text","conversion_output":true,"text":"patients received tandem regimens. Of the 17 patients who underwent tandem transplant, 12 were alive","text_display":" patients received tandem regimens. Of the 17 patients who underwent tandem transplant, 12 were alive","confidence":1,"confidence_rate":1},{"cnt":[[245,2118],[1880,2118],[1880,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2118,"width":1636,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9b75754db53450a949782386a64ed58","type":"text","conversion_output":true,"text":"without evidence of disease at 2 years. The 5 -year EFS and OS rates +/- standard error of the 33 patients","text_display":" without evidence of disease at 2 years. The 5 -year EFS and OS rates +/- standard error of the 33 patients","confidence":0.8105435985963272,"confidence_rate":0.9982511131959978},{"cnt":[[245,2161],[1880,2161],[1880,2211],[245,2211]],"region":{"top_left_x":244,"top_left_y":2161,"width":1636,"height":50},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df91a463a4e0479d852994e4722c4500","type":"text","conversion_output":true,"text":"enrolled was \\(27 \\%+/-8 \\%\\) and \\(39 \\%+/-9 \\%\\), respectively. Twenty-two patients received at least one","text_display":" enrolled was \\(27 \\%+/-8 \\%\\) and \\(39 \\%+/-9 \\%\\), respectively. Twenty-two patients received at least one","confidence":1,"confidence_rate":1},{"cnt":[[245,2206],[1880,2206],[1880,2254],[245,2254]],"region":{"top_left_x":244,"top_left_y":2206,"width":1636,"height":48},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8b92773158c4a35a5d8f9fea6c99e2d","type":"text","conversion_output":true,"text":"transplant, and the 5-year EFS and OS rates from time of first transplant were \\(41 \\%+/-12 \\%\\) and \\(49 \\%+/-\\)","text_display":" transplant, and the 5-year EFS and OS rates from time of first transplant were \\(41 \\%+/-12 \\%\\) and \\(49 \\%+/-","confidence":0.8875314419972636,"confidence_rate":0.9988750546348691},{"cnt":[[247,2252],[1641,2252],[1641,2299],[247,2299]],"region":{"top_left_x":247,"top_left_y":2251,"width":1395,"height":48},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97439b6e5f7542bf910afe98fb51df1d","type":"text","conversion_output":true,"text":"\\(12 \\%\\), respectively (personal communication S. Grupp and W. London, MS in preparation).","text_display":" 12 \\%\\), respectively (personal communication S. Grupp and W. London, MS in preparation).","confidence":0.99462890625,"confidence_rate":0.9999401621244394},{"cnt":[[245,2340],[1878,2340],[1878,2387],[245,2387]],"region":{"top_left_x":244,"top_left_y":2339,"width":1634,"height":48},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2224b87927f4eadba43d47ef9784777","type":"text","conversion_output":true,"text":"The promising results of the CHOP/DFCI experience, the POG 9640 study and the 91LA6 CEM-LI study","text_display":"\n\nThe promising results of the CHOP/DFCI experience, the POG 9640 study and the 91LA6 CEM-LI study","confidence":1,"confidence_rate":1},{"cnt":[[245,2385],[1876,2385],[1876,2430],[245,2430]],"region":{"top_left_x":244,"top_left_y":2384,"width":1632,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b3e8e0e16f34691973a06c0df3f2485","type":"text","conversion_output":true,"text":"have led the COG Neuroblastoma Committee to consider intensification of CEM-LI in a tandem regimen.","text_display":" have led the COG Neuroblastoma Committee to consider intensification of CEM-LI in a tandem regimen.","confidence":1,"confidence_rate":1},{"cnt":[[245,2428],[1880,2428],[1880,2473],[245,2473]],"region":{"top_left_x":244,"top_left_y":2427,"width":1636,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"262c3f0856ec4644abb8e0f1a40e0a9a","type":"text","conversion_output":true,"text":"The feasibility and toxicity of incorporating CEM-LI in a tandem regimen has been studied in COG","text_display":" The feasibility and toxicity of incorporating CEM-LI in a tandem regimen has been studied in COG","confidence":1,"confidence_rate":1},{"cnt":[[245,2471],[1880,2471],[1880,2516],[245,2516]],"region":{"top_left_x":244,"top_left_y":2470,"width":1636,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b465e06cd1a0453e94540fe4a16a24d0","type":"text","conversion_output":true,"text":"ANBL00P1. This limited-institution pilot study utilized five cycles of induction chemotherapy followed","text_display":" ANBL00P1. This limited-institution pilot study utilized five cycles of induction chemotherapy followed","confidence":1,"confidence_rate":1},{"cnt":[[245,2514],[1878,2514],[1878,2563],[245,2563]],"region":{"top_left_x":244,"top_left_y":2513,"width":1634,"height":51},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7bc12bb27324dd290b9871b7941f3fd","type":"text","conversion_output":true,"text":"by tandem transplantation. The tandem regimens were Thiotepa/Cyclophosphamide followed by CEM-LI.","text_display":" by tandem transplantation. The tandem regimens were Thiotepa/Cyclophosphamide followed by CEM-LI.","confidence":1,"confidence_rate":1},{"cnt":[[245,2557],[1880,2557],[1880,2606],[245,2606]],"region":{"top_left_x":244,"top_left_y":2556,"width":1636,"height":51},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76b21f8ad3bc4cc39efbdcf185de577b","type":"text","conversion_output":true,"text":"Thiotepa/Cyclophosphamide regimen was chosen as the initial transplant based upon the known toxicity","text_display":" Thiotepa/Cyclophosphamide regimen was chosen as the initial transplant based upon the known toxicity","confidence":1,"confidence_rate":1},{"cnt":[[1749,2608],[1878,2608],[1878,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":130,"height":46},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7ba6c789469415e81162a2a38bec329","type":"page_info","conversion_output":false,"text":"Page 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POLICY","text_display":"","confidence":0.6495842508738455,"confidence_rate":0.9946217307722369},{"cnt":[[1706,99],[1880,99],[1880,140],[1706,140]],"region":{"top_left_x":1705,"top_left_y":98,"width":175,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58f90e0eb0624415b91dd98c1afaf475","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[329,172],[655,172],[655,208],[329,208]],"region":{"top_left_x":328,"top_left_y":171,"width":328,"height":38},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3cae41d5d2124111aefb295043cc6251","type":"text","conversion_output":true,"text":"Children's Oncology Group","text_display":"\n\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[243,219],[1880,219],[1880,273],[243,273]],"region":{"top_left_x":242,"top_left_y":219,"width":1638,"height":54},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0f5b4846ee243be85f8132d138ef107","type":"text","conversion_output":true,"text":"profile of agents alone and in combination when delivered at myeloablative doses, \\({ }^{28-30}\\) the acceptable","text_display":"\nprofile of agents alone and in combination when delivered at myeloablative doses, \\({ }^{28-30}\\) the acceptable","confidence":1,"confidence_rate":1},{"cnt":[[245,271],[1880,271],[1880,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0048fa42bd6465cbe560ea31466e3ea","type":"text","conversion_output":true,"text":"toxicity profile of the combination demonstrated in the POG 9640 tandem transplant study and the known","text_display":" toxicity profile of the combination demonstrated in the POG 9640 tandem transplant study and the known","confidence":1,"confidence_rate":1},{"cnt":[[245,309],[1880,309],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":309,"width":1636,"height":55},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f90cb40d54954aad9fff1dc1beefa68b","type":"text","conversion_output":true,"text":"anti-neuroblastoma activity of each agent including their ability to cross the blood brain barrier. \\({ }^{31}\\) Data","text_display":" anti-neuroblastoma activity of each agent including their ability to cross the blood brain barrier. \\({ }^{31}\\) Data","confidence":1,"confidence_rate":1},{"cnt":[[245,357],[1880,357],[1880,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":1636,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4bf0ca08e04475cb731c3735712d84b","type":"text","conversion_output":true,"text":"obtained from a CHOP pilot tandem regimen of Thiotepa/Cyclophosphamide followed by full dose CEM","text_display":" obtained from a CHOP pilot tandem regimen of Thiotepa/Cyclophosphamide followed by full dose CEM","confidence":1,"confidence_rate":1},{"cnt":[[245,402],[1880,402],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":401,"width":1636,"height":49},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8b5b2214f3640b9af1902856b4bec1a","type":"text","conversion_output":true,"text":"(equivalent to A3973 dosing) revealed excessive toxicity following CEM. Therefore, a \\(15 \\%\\) dose","text_display":" (equivalent to A3973 dosing) revealed excessive toxicity following CEM. Therefore, a \\(15 \\%\\) dose","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[245,447],[1880,447],[1880,492],[245,492]],"region":{"top_left_x":244,"top_left_y":446,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"948d3257961b479f82f79db4968e26a6","type":"text","conversion_output":true,"text":"reduction of CEM agents was utilized in the ANBL00P1 protocol and will be utilized in ANBL0532. The","text_display":" reduction of CEM agents was utilized in the ANBL00P1 protocol and will be utilized in ANBL0532. The","confidence":1,"confidence_rate":1},{"cnt":[[245,490],[1880,490],[1880,535],[245,535]],"region":{"top_left_x":244,"top_left_y":489,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2d17dd1c94b48f4b92733d6f948a80d","type":"text","conversion_output":true,"text":"observed toxicity following CEM in the CHOP pilot and in the COG A3973 trial suggest that CEM-","text_display":" observed toxicity following CEM in the CHOP pilot and in the COG A3973 trial suggest that CEM","confidence":1,"confidence_rate":1},{"cnt":[[245,533],[1880,533],[1880,580],[245,580]],"region":{"top_left_x":244,"top_left_y":532,"width":1636,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"838ea0cbb67a46f0ad0b3d64bd53b4dc","type":"text","conversion_output":true,"text":"related toxicity would interfere with subsequent delivery of myeloablative chemotherapy and support the","text_display":"related toxicity would interfere with subsequent delivery of myeloablative chemotherapy and support the","confidence":1,"confidence_rate":1},{"cnt":[[245,578],[1708,578],[1708,625],[245,625]],"region":{"top_left_x":244,"top_left_y":577,"width":1465,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"979ebccb652a4eb19b1fff2869ab2c94","type":"text","conversion_output":true,"text":"sequence of thiotepa/cyclophosphamide followed by CEM in a tandem myeloablative regimen.","text_display":" sequence of thiotepa/cyclophosphamide followed by CEM in a tandem myeloablative regimen.","confidence":1,"confidence_rate":1},{"cnt":[[245,666],[1880,666],[1880,711],[245,711]],"region":{"top_left_x":244,"top_left_y":666,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6770d1a584240c6a00f72246f104a49","type":"text","conversion_output":true,"text":"Of the 41 eligible patients enrolled onto ANBL00P1, 8 patients were removed from protocol prior to","text_display":"\n\nOf the 41 eligible patients enrolled onto ANBL00P1, 8 patients were removed from protocol prior to","confidence":0.69921875,"confidence_rate":0.9967228893897415},{"cnt":[[245,709],[1880,709],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1636,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d71ad4f9512407a9ecdc62bf65c069f","type":"text","conversion_output":true,"text":"consolidation. Of the remaining 33 patients, 7 received only a single transplant while 26 patients received","text_display":" consolidation. Of the remaining 33 patients, 7 received only a single transplant while 26 patients received","confidence":0.9990236759185791,"confidence_rate":0.9999919272970785},{"cnt":[[245,752],[1880,752],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e43966d5df9b41e4a5cd0918c46be739","type":"text","conversion_output":true,"text":"tandem transplants. Reasons for not receiving the 2 nd transplant included progressive disease ( 1 patient),","text_display":" tandem transplants. Reasons for not receiving the 2 nd transplant included progressive disease ( 1 patient),","confidence":0.9970715045928955,"confidence_rate":0.9999753549941143},{"cnt":[[245,799],[1880,799],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4bcfd64b34d4640acb9c85b704f9d80","type":"text","conversion_output":true,"text":"family preference (2 patients), mortality following transplant \\#1 ( \\(n =1\\) ) and prolonged toxicity following","text_display":" family preference (2 patients), mortality following transplant \\#1 ( \\(n =1\\) ) and prolonged toxicity following","confidence":0.6545861310470968,"confidence_rate":0.9963847379979927},{"cnt":[[245,842],[1880,842],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":842,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b51ab4f2cfb34718bb68eabaf0c1eba9","type":"text","conversion_output":true,"text":"transplant \\#1 ( \\(n =3\\), delayed engraftment, elevated liver transaminases, renal insufficiency). Therefore,","text_display":" transplant \\#1 ( \\(n =3\\), delayed engraftment, elevated liver transaminases, renal insufficiency). Therefore,","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[245,885],[1880,885],[1880,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf5b158dd7644ff0873dc2d7c3318e8f","type":"text","conversion_output":true,"text":"\\(63 \\%\\) of all patients and \\(79 \\%\\) of those patients eligible for consolidation therapy received the tandem","text_display":" \\(63 \\%\\) of all patients and \\(79 \\%\\) of those patients eligible for consolidation therapy received the tandem","confidence":0.9305419921875,"confidence_rate":0.9993274405192032},{"cnt":[[245,928],[1880,928],[1880,975],[245,975]],"region":{"top_left_x":244,"top_left_y":928,"width":1636,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e19ed255b964358924043baa02dfd28","type":"text","conversion_output":true,"text":"consolidation regimen. This compares favorably to the legacy CCG3891 trial where \\(68 \\%\\) of patients","text_display":" consolidation regimen. This compares favorably to the legacy CCG3891 trial where \\(68 \\%\\) of patients","confidence":0.99755859375,"confidence_rate":0.9999764965133096},{"cnt":[[245,973],[1880,973],[1880,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":973,"width":1636,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb62eef0cf644b9b834007118827ae58","type":"text","conversion_output":true,"text":"assigned to ABMT received the intended therapy. Overall, 3 patients have experienced treatment related","text_display":" assigned to ABMT received the intended therapy. Overall, 3 patients have experienced treatment related","confidence":1,"confidence_rate":1},{"cnt":[[245,1018],[1880,1018],[1880,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1018,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e2c36b658134a05abb77d265456d2fe","type":"text","conversion_output":true,"text":"mortality. Twenty-two events occurred in 41 eligible patients enrolled at diagnosis resulting in 2 -year","text_display":" mortality. Twenty-two events occurred in 41 eligible patients enrolled at diagnosis resulting in 2 -year","confidence":0.6954610347747803,"confidence_rate":0.9968468920066271},{"cnt":[[245,1061],[1880,1061],[1880,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06ad735935134b508bb5d82244403a72","type":"text","conversion_output":true,"text":"EFS from time of diagnosis of \\(38 \\%+/-11 \\%\\). These data support the feasibility of this tandem","text_display":" EFS from time of diagnosis of \\(38 \\%+/-11 \\%\\). These data support the feasibility of this tandem","confidence":0.9960966110229492,"confidence_rate":0.9999604954562582},{"cnt":[[245,1104],[1880,1104],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1104,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5beaa4369f1d4593aba2b78fde61a18d","type":"text","conversion_output":true,"text":"myeloablative chemotherapy regimen, although small numbers of accrued patients limits the ability to","text_display":" myeloablative chemotherapy regimen, although small numbers of accrued patients limits the ability to","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[488,1147],[488,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1147,"width":244,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32945b8146fe4978a5c9654958c19614","type":"text","conversion_output":true,"text":"assess efficacy.","text_display":" assess efficacy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1238],[1880,1238],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1237,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0504d94ab6b44b42ad0a2b19da54f9a0","type":"text","conversion_output":true,"text":"The summary data presented in Table 1 support the investigation of tandem transplant consolidation to","text_display":"\n\nThe summary data presented in Table 1 support the investigation of tandem transplant consolidation to","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[245,1280],[1880,1280],[1880,1328],[245,1328]],"region":{"top_left_x":244,"top_left_y":1280,"width":1636,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa45fd71c6a8498cbb9b802bffb00f6c","type":"text","conversion_output":true,"text":"improve EFS from high risk neuroblastoma. A comparison of the CCG3891 and CHP/DFCI trials, both","text_display":" improve EFS from high risk neuroblastoma. A comparison of the CCG3891 and CHP/DFCI trials, both","confidence":1,"confidence_rate":1},{"cnt":[[245,1326],[1880,1326],[1880,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1325,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dca8cdddcf34409ca1f473977b097815","type":"text","conversion_output":true,"text":"TBI-containing trials, reveals an improvement in EFS following tandem consolidation; (CCG 3891 from","text_display":" TBI-containing trials, reveals an improvement in EFS following tandem consolidation; (CCG 3891 from","confidence":1,"confidence_rate":1},{"cnt":[[245,1369],[1880,1369],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1368,"width":1636,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67c513865dd1474a8894db567c46d683","type":"text","conversion_output":true,"text":"time randomized to ABMT: 8-year EFS 27+/- 5\\% versus CHP/DFCI from diagnosis: 7-year EFS 45+/-","text_display":" time randomized to ABMT: 8-year EFS 27+/- 5\\% versus CHP/DFCI from diagnosis: 7-year EFS 45+/","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[247,1414],[1880,1414],[1880,1459],[247,1459]],"region":{"top_left_x":247,"top_left_y":1413,"width":1633,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b46c75c60600439ea35a7ed8403b9337","type":"text","conversion_output":true,"text":"\\(10 \\%\\) versus CHP/DFCI from time on initial myeloablative regimen: 7 -year EFS \\(49+/-11 \\%\\) ). A trend","text_display":"\\(10 \\%\\) versus CHP/DFCI from time on initial myeloablative regimen: 7 -year EFS \\(49+/-11 \\%\\) ). A trend","confidence":0.9685280324192718,"confidence_rate":0.9996954953957632},{"cnt":[[245,1457],[1880,1457],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1456,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20206504f71b4156b9d20fc392fa4570","type":"text","conversion_output":true,"text":"toward improvement in EFS following tandem transplant is even observed when comparing the highly","text_display":" toward improvement in EFS following tandem transplant is even observed when comparing the highly","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1545],[245,1545]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f4a33a50fdc4f2bb6321f6212c598d5","type":"text","conversion_output":true,"text":"selected cohort of CCG3891 patients who received ABMT and were randomized to receive cis-RA ( \\(26 \\%\\)","text_display":" selected cohort of CCG3891 patients who received ABMT and were randomized to receive cis-RA ( \\(26 \\%\\)","confidence":0.98779296875,"confidence_rate":0.9998784019580803},{"cnt":[[245,1543],[1880,1543],[1880,1590],[245,1590]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bd85297775148b5afe5235f4874e10f","type":"text","conversion_output":true,"text":"of those patients patients randomized to ABMT) versus the CHP/DFCI patients who received the","text_display":" of those patients patients randomized to ABMT) versus the CHP/DFCI patients who received the","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[1880,1590],[1880,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1589,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa8eed45e02043809b2ab28238bfafe2","type":"text","conversion_output":true,"text":"intended tandem transplant ( \\(84.5 \\%\\) of patients enrolled); CCG 3891: 8-year EFS \\(44+/-12 \\%\\) versus","text_display":" intended tandem transplant ( \\(84.5 \\%\\) of patients enrolled); CCG 3891: 8-year EFS \\(44+/-12 \\%\\) versus","confidence":0.9926915031444984,"confidence_rate":0.9999301421091117},{"cnt":[[245,1633],[1880,1633],[1880,1678],[245,1678]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16cc6e612ae84a3eab278685e5cecc90","type":"text","conversion_output":true,"text":"CHP/DFCI 7-year EFS 52 +/- 11\\%. Furthermore, the 91LA6 data suggests that CEM provides similar","text_display":" CHP/DFCI 7-year EFS 52 +/- 11\\%. Furthermore, the 91LA6 data suggests that CEM provides similar","confidence":0.9970715045928955,"confidence_rate":0.9999712475521841},{"cnt":[[245,1676],[1880,1676],[1880,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1675,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"855561304d28437d8a3eaa91d48193bd","type":"text","conversion_output":true,"text":"EFS to the single TBI-CEM containing regimen used in CCG3891, supporting the elimination of TBI","text_display":" EFS to the single TBI-CEM containing regimen used in CCG3891, supporting the elimination of TBI","confidence":1,"confidence_rate":1},{"cnt":[[245,1719],[1880,1719],[1880,1766],[245,1766]],"region":{"top_left_x":244,"top_left_y":1718,"width":1636,"height":49},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b86b5dd9bbd49a095f53f34e0d3c13b","type":"text","conversion_output":true,"text":"from a tandem regimen. The EFS and OS results of the various non-TBI containing tandem regimens","text_display":" from a tandem regimen. The EFS and OS results of the various non-TBI containing tandem regimens","confidence":1,"confidence_rate":1},{"cnt":[[245,1764],[1882,1764],[1882,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1763,"width":1639,"height":49},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b33c2c4a7ec649b58d7c6208e73ae209","type":"text","conversion_output":true,"text":"(ANBL00P1 and POG 9640) vary between studies, reflecting the difficulty in evaluating efficacy of","text_display":" (ANBL00P1 and POG 9640) vary between studies, reflecting the difficulty in evaluating efficacy of","confidence":0.9990236759185791,"confidence_rate":0.9999904235654993},{"cnt":[[245,1809],[1880,1809],[1880,1854],[245,1854]],"region":{"top_left_x":244,"top_left_y":1808,"width":1636,"height":47},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"921c875e8e8e4b0ba97952cd216c46c5","type":"text","conversion_output":true,"text":"therapy regimens in small, non-randomized clinical trials. However, the combined data from the","text_display":" therapy regimens in small, non-randomized clinical trials. However, the combined data from the","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1852],[1880,1852],[1880,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1851,"width":1636,"height":47},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a47215bd71145938b3c8aa3f098bc5c","type":"text","conversion_output":true,"text":"CHP/DFCI, the POG 9640 and the ANBL00P1 trials demonstrate that intensification of consolidation","text_display":" CHP/DFCI, the POG 9640 and the ANBL00P1 trials demonstrate that intensification of consolidation","confidence":1,"confidence_rate":1},{"cnt":[[245,1895],[1880,1895],[1880,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1894,"width":1636,"height":51},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"097abfc987764a57b8d9aeffd6a38f16","type":"text","conversion_output":true,"text":"therapy with PBSC support is feasible, does not increase treatment related mortality and may decrease","text_display":" therapy with PBSC support is feasible, does not increase treatment related mortality and may decrease","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1063,1938],[1063,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1937,"width":820,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ae30039a490479187310d0fb69226ac","type":"text","conversion_output":true,"text":"recurrence for patients with high-risk neuroblastoma.","text_display":" recurrence for patients with high-risk neuroblastoma.","confidence":1,"confidence_rate":1},{"cnt":[[1749,2608],[1878,2608],[1878,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":130,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2d8f45361f64c5fa1ea027b47dafba7","type":"page_info","conversion_output":false,"text":"Page 18","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-019","page":19,"lines":[{"cnt":[[247,99],[614,99],[614,165],[247,165]],"region":{"top_left_x":247,"top_left_y":98,"width":368,"height":68},"line":1,"column":0,"font_size":70,"is_printed":true,"is_handwritten":false,"id":"158cfb90fb7d429f9839ec80b5c9eb30","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,105],[1652,105],[1652,140],[653,140]],"region":{"top_left_x":653,"top_left_y":105,"width":1000,"height":35},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"22f06688a07a4c79835913e5d6640908","type":"page_info","conversion_output":false,"text":"This protocol is for research purposes only, see page 1 for usage policy","text_display":"","confidence":0.5089783025914224,"confidence_rate":0.9915936589220454},{"cnt":[[1706,103],[1880,103],[1880,140],[1706,140]],"region":{"top_left_x":1705,"top_left_y":103,"width":175,"height":37},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1803515f2ea441e8a117e754315996b0","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,172],[651,172],[651,208],[331,208]],"region":{"top_left_x":330,"top_left_y":171,"width":321,"height":38},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fc3fbf359c264e1d8d32674bf2eec185","type":"text","conversion_output":true,"text":"Children's Oncology Group","text_display":"\n\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[275,228],[1807,228],[1807,271],[275,271]],"region":{"top_left_x":275,"top_left_y":227,"width":1532,"height":44},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1632881fa504d09810bd7c749a1753c","type":"figure_label","conversion_output":false,"text":"Table 1. Comparison of Myeloablative Regimens for Treatment of High Risk Neuroblastoma","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[277,264],[1869,264],[1869,1629],[277,1629]],"region":{"top_left_x":277,"top_left_y":264,"width":1593,"height":1365},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19860dbbc35a48db86fc250c6ab0e2c5","type":"table","conversion_output":true,"children_ids":["f7e2de8eca044103abc2f0d86c721a4c","dadfadd4372047aeac7e54a1a506ef72","a17faf283be541e28b07c91dd571feb8","b2d83c3e7b5c4cac8287613baa15e1ef","42d875ba74ef4f3fa9c33a025341aa08","5c770c6469ab4e96a9837be33e42e02e","8993f151f14149a5b64ce88a9eac4b82","ed4e856418ba4eff84a40f24629043ce","b9af01b1797b499390fbbde8051b8361","0441c730767b44088954c3cac5c7b18f","67eff709f44b4fb58bb2334a283bbd47","e3acd5dbde244a0c85460b2753afd345","7365533e96424fd08a9ec0f2a761580d","29e67666fb24421bbde8b481154cb282","bc198585a1ba4e9db6500bc11bebc757","78b0dc96e33441969f0198236b06b1db","123d97f0d7cb4850ae3c43fbbfcc5ca4","f27371aa05cb4bf3b9df14e1b546cbc7","b61bdee0a4bd429892fd6b1a44b33e41","891728ed908e4d70881375702475aa38","9bb6bafcc8e2414e9206bbdb5c449c10","eac24378b6124a25b5eb7617094263ba","fbd15e2d70f74c8ca077c9da2a935b89","9009aa3649764aedb0652480f86c6d72","753022bfa71f4689bd1c1a8c4d91ac02","528bad19c1f6492c9b8c91d54cb5f97c","fca71fc7c2cb467c913228e611858e5c","df381f52b4e7476f85bc66f02e4c5258","b03ac57e91984808ae021364bd4c0865","067f7c7d624f4264a1969523472b1f26","0a01ce52dc364e0e84b98b3db1809892","3a13c6c526364108a809677e4fabf59e","5d206baedc7c4852a3ce7e12dda1dce5","7782da063a1b4e038df6c3f100c1c368","1cacbebfc2fb44458f66c3448d2408dc","a33dd78fcc454f61b049b2de6c6a3483","027cdf35336f40e7ad6e88db234d6374","b21ff37de2f94acd9cfe6a872a0859c0","74989d14fd1443f78986dc5b83895ce9","29537bdb7e65420b8a892cfa9a1e2721","d4e53fc423114fca984f5a7280a643ff","594ab318a5b54bc2a4e4497c17ba579c","c7201fcdf38c4adf9dd946c9fcb101bd","4af48aa4e7f34f60bbfcc16c4a1b3292","c5b1b386761c4159bf817f060bb597b9","f31e5685941d45208ef96035ecaaccbd","f6b4d9784aa4499d8ca4993e6bbe4a2b","901073e005b54dce8284c30e5d381b93","ada0b716b96a4e248651873245eeb9af","dd6cfb2369d54e2cac376b81d5ff9ece","cd2a77d6999a4899ba4a55455e6c205f","91c18fabe705438597d8555d79d45bcc","d7d21ab4fbe449f7882634b60cf3fe72","bed615e3c8674ffab22bec690828df9e","1490b7009b6244dab82d9ad4c34466e6","6ef4de271a9641dab15d922350ad4143","2d8965dcf4fd4038afdeff3cbc2de949","63ff4ad475954beea7c39e5a240b325c","9dc0436633a24ce7abc43e126e746f0e","7d5ad6c3439d4fbb9bcbd30e68d7a551","7714714df59e42de9e8425698cafd9ff","907eecc2bc634270a1a5034938d05992","2285b18cce6c46af8d09ff922397f2d2","ba4030c5cf324b9fac402f2e432c0f60","5959655ff7d543cbafdfdcbef774d1a7","8636a8d8367443398db6c23107525d09","d972293846b646b4934ddc58b21bc2f8","432aab228b6446de8852adeeb7d5941b","07aa653bebf9466bb9ef708e88d44192","0a4a64bd99b34da8994d248510160f3a","a9d734048722489889559326e421e729","6b7101b7a4c84209a024faea3aa3e213","a052954b159e4abf823f740d38b8498e","057306cabe2c4001aa9bcc55daf693d0","6fb4da15d2a04e79b9eaa96c696dd8b3","04ec3f768a84429ebcdf0a42d9e45561","0942756531b64f28bd36fc649968b2dd","ed9e1ce776df473eb05a9e3ac1751ddd","5cea21b8ead04a7380dedc54ba41a80a","b40ceef81d774e23b77e5f700f215936","45361829ce934af8a0f06a7ab112b82f","0b6259ee7fb14e38b21fdadb22e70474","70b09be6518b45cd91fb777d1e19487f","57e8f55c43ca4d4dbc9f2517b988fd2b","14225b3869c746cabfe22bb1559d4fa1","eef36bfc997240708b234504f4337440","d06e10e2242a455eaa76c24884f089c7","670860e359694e72965cc6938037c87f","6d2a08b68b144060939539a9b5b5660b","8ddb6107d5c2465bbf13fcf67f1d2e80"],"selected_labels":["a1632881fa504d09810bd7c749a1753c"],"text":"\\begin{tabular}{|l|l|l|l|l|l|l|l|}\n\\hline & CCG3891 Overall \\(N =539\\) (379 randomized) & CCG3891 ABMT \\(N =189\\) (129 received ABMT) & CEM-L1 (91LA6) \\(N =73\\) & CHP594/ DFCI34 \\(N =97\\) & POG9640 \\(N =33\\) & ANBL00P1 \\(N =41\\) & ANBL02P1 \\(N =31\\) \\\\\n\\hline Preconsolidation Response (\\%CR/ VGPR) & \\begin{tabular}{l}\nCR + VGPR 50\\% (190/379) \\\\\nPD=50/379\n\\end{tabular} & \\begin{tabular}{l}\nCR+ VGPR 52\\% (98/189) \\\\\nPD=28/189\n\\end{tabular} & CR + V GPR 53\\% & \\begin{tabular}{l}\nCR+VGPR +PR+MR 94\\% (91/97) \\\\\n\\(PD =6 / 97\\)\n\\end{tabular} & CR+ VGPR 70\\% (23/33) & CR+VGPR+P \\(R + MR\\) 90\\% (37/41) & CR/VGPR 50\\% (13/26) \\\\\n\\hline \\% stem cell collections \\(>4 \\times 10 e 6 / kg\\) & BM source & BM source & NA & NA different induction & NA different induction & NA different induction & 88\\% \\((23 / 26)^{6}\\) \\\\\n\\hline \\%EFS at 2y & & & \\(56 \\pm 6 \\%^{4}\\) & & \\(46 \\pm 9 \\%^{2} 55 \\pm 11 \\%^{4}\\) & \\(38 \\pm 11 \\%^{2} 39.5 \\pm 14 \\%^{3}\\) & Too early \\\\\n\\hline \\%EFS at 3y & \\(30 \\pm 2 \\%^{2}\\) & \\(34 \\pm 4 \\%^{2} 43 \\pm 6 \\%^{3}\\) & \\(49 \\pm 6 \\%^{4}\\) & \\(55 \\pm 9 \\%^{2} 59 \\pm 9 \\%^{4} 61 \\pm 10 \\%^{5}\\) & \\(33 \\pm 8 \\%^{2} 41 \\pm 11 \\%^{4}\\) & \\(38 \\pm 21 \\%^{4}\\) & NA \\\\\n\\hline \\% EFS at 5y & \\(25 \\pm 2 \\%^{2}\\) & & \\(47 \\pm 6 \\%^{4}\\) & \\(47 \\pm 9 \\%^{2} 51 \\pm 10 \\%^{4} 54 \\pm 11 \\%^{5}\\) & \\(27 \\pm 8 \\%^{2} 41 \\pm 12 \\%^{4}\\) & & NA \\\\\n\\hline \\% EFS at 7y & \\(24 \\pm 3 \\%^{1,2}\\) & \\(27 \\pm 5 \\%^{1,2} 44 \\pm 12 \\%^{1,3}\\) & \\(40 \\pm 7 \\%^{4}\\) & \\(45 \\pm 10 \\%^{2} 49 \\pm 11 \\%^{4} 52 \\pm 11 \\%^{5}\\) & & Too early & NA \\\\\n\\hline \\% local relapse & & \\(33 \\pm 7 \\%\\) & 9.9\\% & 12.4\\% & Data not available & Data not available & Data not available \\\\\n\\hline \\% second cancer & 0.55\\% (3/539) 2 leuk, 1 clear cell sarcoma & 0.5\\% (1/189) & 2.8\\% (2/73) & 2\\% (2/97) & 3\\% (1/33) & Data not available & Too early \\\\\n\\hline \\% HSCTrelated toxic deaths & 4\\% (22/539) & 7\\% (9/129) & 5\\% (4/73) & 5\\% (5/97) & 0\\% (0/22) & 6\\% (2/33) & 6\\% (2/31) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 1. Comparison of Myeloablative Regimens for Treatment of High Risk Neuroblastoma}\n\\begin{tabular}{|l|l|l|l|l|l|l|l|}\n\\hline & CCG3891 Overall \\(N =539\\) (379 randomized) & CCG3891 ABMT \\(N =189\\) (129 received ABMT) & CEM-L1 (91LA6) \\(N =73\\) & CHP594/ DFCI34 \\(N =97\\) & POG9640 \\(N =33\\) & ANBL00P1 \\(N =41\\) & ANBL02P1 \\(N =31\\) \\\\\n\\hline Preconsolidation Response (\\%CR/ VGPR) & \\begin{tabular}{l}\nCR + VGPR 50\\% (190/379) \\\\\nPD=50/379\n\\end{tabular} & \\begin{tabular}{l}\nCR+ VGPR 52\\% (98/189) \\\\\nPD=28/189\n\\end{tabular} & CR + V GPR 53\\% & \\begin{tabular}{l}\nCR+VGPR +PR+MR 94\\% (91/97) \\\\\n\\(PD =6 / 97\\)\n\\end{tabular} & CR+ VGPR 70\\% (23/33) & CR+VGPR+P \\(R + MR\\) 90\\% (37/41) & CR/VGPR 50\\% (13/26) \\\\\n\\hline \\% stem cell collections \\(>4 \\times 10 e 6 / kg\\) & BM source & BM source & NA & NA different induction & NA different induction & NA different induction & 88\\% \\((23 / 26)^{6}\\) \\\\\n\\hline \\%EFS at 2y & & & \\(56 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early in the clinical course (diagnosis","text_display":" to etoposide. \\({ }^{44}\\) Patient-derived neuroblastoma cell lines established early in the clinical course (diagnosis","confidence":0.9795019626617432,"confidence_rate":0.9998329894489346},{"cnt":[[245,799],[1884,799],[1884,849],[245,849]],"region":{"top_left_x":244,"top_left_y":799,"width":1641,"height":50},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1467d62bfd0c40f69c13bf60a72e656c","type":"text","conversion_output":true,"text":"or after induction therapy) were more likely to be sensitive to topotecan, supporting the incorporation of","text_display":" or after induction therapy) were more likely to be sensitive to topotecan, supporting the incorporation 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In vivo, topotecan is eliminated","text_display":" topotecan into Induction therapy, prior to significant etoposide exposure. In vivo, topotecan is eliminated","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1880,885],[1880,935],[245,935]],"region":{"top_left_x":244,"top_left_y":885,"width":1636,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87885cbe1c764ae7be0aa020458efa2c","type":"text","conversion_output":true,"text":"through hepatic metabolism and renal excretion. Topotecan penetrates the CNS, \\({ }^{45}\\) a site of recurrence in","text_display":" through hepatic metabolism and renal excretion. Topotecan penetrates the CNS, \\({ }^{45}\\) a site of recurrence in","confidence":1,"confidence_rate":1},{"cnt":[[245,928],[1880,928],[1880,982],[245,982]],"region":{"top_left_x":244,"top_left_y":928,"width":1636,"height":54},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5ff477e75194397b1a4d8dae08fb5e3","type":"text","conversion_output":true,"text":"neuroblastoma. \\({ }^{46}\\) Topotecan has a limited toxicity profile notable for dose-limiting myelosuppression and","text_display":" neuroblastoma. \\({ }^{46}\\) Topotecan has a limited toxicity profile notable for dose-limiting myelosuppression and","confidence":1,"confidence_rate":1},{"cnt":[[245,971],[1880,971],[1880,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":971,"width":1636,"height":54},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e4522797a084b8fa57fb1037763a094","type":"text","conversion_output":true,"text":"mild to moderate nausea, vomiting and mucositis, regardless of administration schedule. \\({ }^{47-49}\\) Anti-","text_display":" mild to moderate nausea, vomiting and mucositis, regardless of administration schedule. \\({ }^{47-49}\\) Anti","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,1018],[1880,1018],[1880,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1018,"width":1636,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12a1eca7ee5149fbad8b76a82093d685","type":"text","conversion_output":true,"text":"neuroblastoma activity has been demonstrated in both Phase I and II trials. A Phase I trial administered","text_display":"neuroblastoma activity has been demonstrated in both Phase I and II trials. A Phase I trial administered","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1880,1061],[1880,1111],[245,1111]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6912e0a388bc4bc5af469f490b05f094","type":"text","conversion_output":true,"text":"topotecan at dosages of \\(1.4 mg / m ^{2} /\\) day to \\(2.4 mg / m ^{2} /\\) day for 5 days to pediatric patients with recurrent","text_display":" topotecan at dosages of \\(1.4 mg / m ^{2} /\\) day to \\(2.4 mg / m ^{2} /\\) day for 5 days to pediatric patients with recurrent","confidence":0.9815041774418205,"confidence_rate":0.9998685367470261},{"cnt":[[245,1109],[1880,1109],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1108,"width":1636,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f371cc31cf1a4408bd59c3ec127f8567","type":"text","conversion_output":true,"text":"tumors. Of nine patients with neuroblastoma, a partial response was demonstrated in 3 patients while","text_display":" tumors. Of nine patients with neuroblastoma, a partial response was demonstrated in 3 patients while","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1880,1147],[1880,1199],[245,1199]],"region":{"top_left_x":244,"top_left_y":1147,"width":1636,"height":52},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d41e810c7210482da085265d2deefb13","type":"text","conversion_output":true,"text":"stable disease occurred in one patient. \\({ }^{42}\\) A Phase II upfront window trial in patients with newly diagnosed","text_display":" stable disease occurred in one patient. \\({ }^{42}\\) A Phase II upfront window trial in patients with newly diagnosed","confidence":1,"confidence_rate":1},{"cnt":[[245,1190],[1880,1190],[1880,1244],[245,1244]],"region":{"top_left_x":244,"top_left_y":1190,"width":1636,"height":54},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"259bb400234d4adf865d6c2ee8c85808","type":"text","conversion_output":true,"text":"high-risk neuroblastoma (POG-9341) identified topotecan ( \\(2 mg / m ^{2} /\\) day for 5 days) as an active anti-","text_display":" high-risk neuroblastoma (POG-9341) identified topotecan ( \\(2 mg / m ^{2} /\\) day for 5 days) as an active anti","confidence":0.6633973284624517,"confidence_rate":0.9966959448022045},{"cnt":[[245,1240],[1880,1240],[1880,1287],[245,1287]],"region":{"top_left_x":244,"top_left_y":1239,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abebf51bf0cc4d4fb1bfe7bcaf2d0370","type":"text","conversion_output":true,"text":"neuroblastoma agent with \\(38 \\%\\) of patients achieving a complete ( \\(n =1\\) ) or partial tumor response ( \\(n =11\\) )","text_display":"neuroblastoma agent with \\(38 \\%\\) of patients achieving a complete ( \\(n =1\\) ) or partial tumor response ( \\(n =11\\) )","confidence":0.5590081214904785,"confidence_rate":0.9953207298202649},{"cnt":[[245,1280],[1880,1280],[1880,1330],[245,1330]],"region":{"top_left_x":244,"top_left_y":1280,"width":1636,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5e13f70bb4b4906b784966d8209ccb4","type":"text","conversion_output":true,"text":"following 2 cycles of single agent therapy. \\({ }^{32}\\) In a more traditional topotecan single agent Phase II trial","text_display":" following 2 cycles of single agent therapy. \\({ }^{32}\\) In a more traditional topotecan single agent Phase II trial","confidence":1,"confidence_rate":1},{"cnt":[[245,1323],[1880,1323],[1880,1377],[245,1377]],"region":{"top_left_x":244,"top_left_y":1323,"width":1636,"height":55},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a0c74d72e7c4c45bd3e0098ace8f209","type":"text","conversion_output":true,"text":"(topotecan \\(2 mg / m ^{2} /\\) day for 5 days) enrolling 37 patients with refractory neuroblastoma, complete","text_display":" (topotecan \\(2 mg / m ^{2} /\\) day for 5 days) enrolling 37 patients with refractory neuroblastoma, complete","confidence":0.9936552047729492,"confidence_rate":0.9999482532983612},{"cnt":[[245,1371],[1880,1371],[1880,1420],[245,1420]],"region":{"top_left_x":244,"top_left_y":1370,"width":1636,"height":51},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"834012d3d064450fbf3b4d5e9a978cce","type":"text","conversion_output":true,"text":"response (CR) was achieved in 2 patients, mixed response (MR) in 5 patients and stable disease (SD) in 8","text_display":" response (CR) was achieved in 2 patients, mixed response (MR) in 5 patients and stable disease (SD) in 8","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,1412],[1880,1412],[1880,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1411,"width":1636,"height":53},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7bc9722767e94c3ea933e537011432c2","type":"text","conversion_output":true,"text":"patients. \\({ }^{50}\\) These data are consistent with topotecan's anti- neuroblastoma efficacy documented in pre-","text_display":" patients. \\({ }^{50}\\) These data are consistent with topotecan's anti- neuroblastoma efficacy documented in pre","confidence":1,"confidence_rate":1},{"cnt":[[245,1457],[1755,1457],[1755,1506],[245,1506]],"region":{"top_left_x":244,"top_left_y":1456,"width":1512,"height":51},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af5ee42f73174156b111649033a3c748","type":"text","conversion_output":true,"text":"clinical studies and support the incorporation of topotecan into upfront therapy for neuroblastoma.","text_display":"clinical studies and support the incorporation of topotecan into upfront therapy for neuroblastoma.","confidence":1,"confidence_rate":1},{"cnt":[[236,1543],[952,1543],[952,1601],[236,1601]],"region":{"top_left_x":236,"top_left_y":1542,"width":716,"height":59},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7b22e47ae43472e8c2c12a52339f9ea","type":"section_header","conversion_output":false,"children_ids":["b5c25a875de9407caeaca1eac8a942ac"],"text":"","text_display":""},{"cnt":[[245,1547],[947,1547],[947,1594],[245,1594]],"region":{"top_left_x":244,"top_left_y":1546,"width":704,"height":49},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5c25a875de9407caeaca1eac8a942ac","type":"text","conversion_output":true,"parent_id":"e7b22e47ae43472e8c2c12a52339f9ea","text":"2.7 Topotecan and Cyclophosphamide","text_display":"\n\n\\subsection*{2.7 Topotecan and Cyclophosphamide}","confidence":0.99951171875,"confidence_rate":0.9999874769887185},{"cnt":[[245,1590],[1880,1590],[1880,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1589,"width":1636,"height":51},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f82b229401e645a185ae42c6b5a238b0","type":"text","conversion_output":true,"text":"Topotecan and cyclophosphamide have been successfully combined without excessive toxicity and have","text_display":"\n\nTopotecan and cyclophosphamide have been successfully combined without excessive toxicity and have","confidence":1,"confidence_rate":1},{"cnt":[[245,1635],[1880,1635],[1880,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1634,"width":1636,"height":49},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c505a518c8f1491cb6fd9db1e0df4cf9","type":"text","conversion_output":true,"text":"anti-neuroblastoma activity. A phase I trial in pediatric patients with refractory or recurrent solid tumors","text_display":" anti-neuroblastoma activity. A phase I trial in pediatric patients with refractory or recurrent solid tumors","confidence":1,"confidence_rate":1},{"cnt":[[245,1676],[1880,1676],[1880,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1675,"width":1636,"height":51},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"922432715dde4e0da862d8a4c978e56e","type":"text","conversion_output":true,"text":"demonstrated the topotecan MTD as \\(0.75 mg / m ^{2} /\\) day administered over 30 minutes daily for 5 days in","text_display":" demonstrated the topotecan MTD as \\(0.75 mg / m ^{2} /\\) day administered over 30 minutes daily for 5 days in","confidence":1,"confidence_rate":1},{"cnt":[[245,1719],[1880,1719],[1880,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1718,"width":1636,"height":55},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df964009a45c42c0a5f6e707c05be0af","type":"text","conversion_output":true,"text":"combination with cyclophosphamide \\(250 mg / m ^{2} /\\) day administered daily for 5 days. \\({ }^{51}\\) Myelosuppression,","text_display":" combination with cyclophosphamide \\(250 mg / m ^{2} /\\) day administered daily for 5 days. \\({ }^{51}\\) Myelosuppression,","confidence":1,"confidence_rate":1},{"cnt":[[245,1766],[1880,1766],[1880,1813],[245,1813]],"region":{"top_left_x":244,"top_left_y":1766,"width":1636,"height":48},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8534f79937f543ab8ff0c855be63db90","type":"text","conversion_output":true,"text":"defined as Grade 4 neutropenia, was the dose limiting toxicity without additional significant toxicity","text_display":" defined as Grade 4 neutropenia, was the dose limiting toxicity without additional significant toxicity","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[245,1807],[1880,1807],[1880,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1806,"width":1636,"height":53},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a242011a885343de8953300a6db81cc5","type":"text","conversion_output":true,"text":"observed. Anti-tumor activity was further evaluated in a Phase II trial of topotecan \\(0.75 mg / m ^{2} /\\) day x 5","text_display":" observed. Anti-tumor activity was further evaluated in a Phase II trial of topotecan \\(0.75 mg / m ^{2} /\\) day x 5","confidence":0.57666015625,"confidence_rate":0.9955343732968801},{"cnt":[[245,1852],[1880,1852],[1880,1901],[245,1901]],"region":{"top_left_x":244,"top_left_y":1851,"width":1636,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4dc44e787d24c67978830bc14961424","type":"text","conversion_output":true,"text":"days combined with cyclophosphamide \\(250 mg / m ^{2} /\\) day for 5 days administered to 83 pediatric patients","text_display":" days combined with cyclophosphamide \\(250 mg / m ^{2} /\\) day for 5 days administered to 83 pediatric patients","confidence":1,"confidence_rate":1},{"cnt":[[245,1893],[1880,1893],[1880,1946],[245,1946]],"region":{"top_left_x":244,"top_left_y":1892,"width":1636,"height":55},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"497dc2e2f1eb4de080aa0132440db90a","type":"text","conversion_output":true,"text":"with refractory solid tumors. \\({ }^{52}\\) Six of thirteen patients with refractory/recurrent neuroblastoma ( 5","text_display":" with refractory solid tumors. \\({ }^{52}\\) Six of thirteen patients with refractory/recurrent neuroblastoma ( 5","confidence":0.90478515625,"confidence_rate":0.9991303109217897},{"cnt":[[245,1942],[1880,1942],[1880,1989],[245,1989]],"region":{"top_left_x":244,"top_left_y":1942,"width":1636,"height":48},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c5833bb12bc47e8b0852e2aaaf302ca","type":"text","conversion_output":true,"text":"received prior HSCT) achieved a PR ( 3 had received a prior BMT), while 2 patients achieved mixed","text_display":" received prior HSCT) achieved a PR ( 3 had received a prior BMT), while 2 patients achieved mixed","confidence":0.85791015625,"confidence_rate":0.998581970263305},{"cnt":[[245,1987],[1880,1987],[1880,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1987,"width":1636,"height":48},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0b64fd6b71242dfa884ebc84804cd6e","type":"text","conversion_output":true,"text":"response or stable disease. Preliminary data from POG-9642, a randomized study of topotecan (2","text_display":" response or stable disease. Preliminary data from POG-9642, a randomized study of topotecan (2","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[245,2024],[1880,2024],[1880,2078],[245,2078]],"region":{"top_left_x":244,"top_left_y":2023,"width":1636,"height":55},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30312cc25e2a4415a68a25a793ef6cda","type":"text","conversion_output":true,"text":"\\(mg / m ^{2} /\\) day for 5 days) versus topotecan/cyclophosphamide (at Phase II doses noted above) in patients","text_display":" \\(mg / m ^{2} /\\) day for 5 days) versus topotecan/cyclophosphamide (at Phase II doses noted above) in patients","confidence":0.9648771286010742,"confidence_rate":0.9997020901037635},{"cnt":[[245,2075],[1880,2075],[1880,2121],[245,2121]],"region":{"top_left_x":244,"top_left_y":2075,"width":1636,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d798c1c874be44e9b6c7df63e65a955d","type":"text","conversion_output":true,"text":"with recurrent neuroblastoma demonstrate a trend toward improved CR/PR rate following","text_display":" with recurrent neuroblastoma demonstrate a trend toward improved CR/PR rate following","confidence":1,"confidence_rate":1},{"cnt":[[245,2118],[1880,2118],[1880,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2118,"width":1636,"height":50},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ee140960976467593bc506a1d07f056","type":"text","conversion_output":true,"text":"topotecan/cyclophosphamide therapy ( \\(34 \\%\\) versus 20\\%), decreased rate of grade 3 or 4 infectious","text_display":" topotecan/cyclophosphamide therapy ( \\(34 \\%\\) versus 20\\%), decreased rate of grade 3 or 4 infectious","confidence":0.5152788734940259,"confidence_rate":0.993935463777468},{"cnt":[[245,2161],[1858,2161],[1858,2211],[245,2211]],"region":{"top_left_x":244,"top_left_y":2161,"width":1615,"height":50},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b62b8df27d34fc695b5c52808c60254","type":"text","conversion_output":true,"text":"complications and increased time to tumor progression (Frantz C., COG 9462 Public Report, 2/11/2003).","text_display":" complications and increased time to tumor progression (Frantz C., COG 9462 Public Report, 2/11/2003).","confidence":1,"confidence_rate":1},{"cnt":[[245,2247],[1880,2247],[1880,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2247,"width":1636,"height":50},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0ec46b9b6c04ee7a062290d1c90820a","type":"text","conversion_output":true,"text":"Xenograft models predict that higher systemic exposure ( \\(52-88 ng / ml * hr\\) ) to topotecan will improve","text_display":"\n\nXenograft models predict that higher systemic exposure ( \\(52-88 ng / ml * hr\\) ) to topotecan will improve","confidence":0.9196481405524537,"confidence_rate":0.9992718813982637},{"cnt":[[245,2290],[1880,2290],[1880,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2290,"width":1636,"height":50},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c170afa8edd54bc7bf16de96f43d370e","type":"text","conversion_output":true,"text":"tumor response. \\({ }^{38}\\) A topotecan systemic exposure of \\(52-88 ng / ml { }^{*} hr\\) is predicted to be achieved by","text_display":" tumor response. \\({ }^{38}\\) A topotecan systemic exposure of \\(52-88 ng / ml { }^{*} hr\\) is predicted to be achieved by","confidence":0.723446337506175,"confidence_rate":0.9975128756750182},{"cnt":[[245,2333],[1880,2333],[1880,2385],[245,2385]],"region":{"top_left_x":244,"top_left_y":2333,"width":1636,"height":52},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"332c79e263354ca6a5e590d6fe4bd282","type":"text","conversion_output":true,"text":"doses of 1.0 to \\(1.6 mg / m ^{2} /\\) day. \\({ }^{42}\\) Limited pediatric trials, both non-myeloablative and myeloablative, have","text_display":" doses of 1.0 to \\(1.6 mg / m ^{2} /\\) day. \\({ }^{42}\\) Limited pediatric trials, both non-myeloablative and myeloablative, have","confidence":0.998046875,"confidence_rate":0.9999860355629622},{"cnt":[[245,2380],[1880,2380],[1880,2430],[245,2430]],"region":{"top_left_x":244,"top_left_y":2380,"width":1636,"height":50},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52c41944ff044875944193323771a2f6","type":"text","conversion_output":true,"text":"incorporated such doses of topotecan. Repetitive delivery of a dose-intensive topotecan and","text_display":" incorporated such doses of topotecan. Repetitive delivery of a dose-intensive topotecan and","confidence":1,"confidence_rate":1},{"cnt":[[245,2426],[1880,2426],[1880,2473],[245,2473]],"region":{"top_left_x":244,"top_left_y":2425,"width":1636,"height":48},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"482b74c925e8471dac698fec81441a1f","type":"text","conversion_output":true,"text":"cyclophosphamide regimen (MSKCC regimen), continuous infusion high-dose cyclophosphamide ( 4200","text_display":" cyclophosphamide regimen (MSKCC regimen), continuous infusion high-dose cyclophosphamide ( 4200","confidence":0.9921875,"confidence_rate":0.9999207791233815},{"cnt":[[245,2464],[1880,2464],[1880,2516],[245,2516]],"region":{"top_left_x":244,"top_left_y":2464,"width":1636,"height":52},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e97644acdfb4d27b4fb59eba44a9967","type":"text","conversion_output":true,"text":"\\(mg / m ^{2} / 48\\) hours) combined with continuous infusion topotecan ( \\(6 mg / m ^{2} / 72\\) hours), has been","text_display":" \\(mg / m ^{2} / 48\\) hours) combined with continuous infusion topotecan ( \\(6 mg / m ^{2} / 72\\) hours), has been","confidence":0.9990236759185791,"confidence_rate":0.9999919272970785},{"cnt":[[245,2509],[1880,2509],[1880,2563],[245,2563]],"region":{"top_left_x":244,"top_left_y":2509,"width":1636,"height":55},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f61e1a6cb34649f1bcb0a38b0d36300c","type":"text","conversion_output":true,"text":"administered to pediatric patients with recurrent solid tumors. \\({ }^{53}\\) Severe neutropenia was observed","text_display":" administered to pediatric patients with recurrent solid tumors. \\({ }^{53}\\) Severe neutropenia was observed","confidence":1,"confidence_rate":1},{"cnt":[[245,2557],[1880,2557],[1880,2606],[245,2606]],"region":{"top_left_x":244,"top_left_y":2556,"width":1636,"height":51},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b416860ec5504b8fb8fdead6ea312200","type":"text","conversion_output":true,"text":"following all courses of therapy, with \\(89 \\%\\) of courses complicated by fever and \\(5.9 \\%\\) complicated by","text_display":" following all courses of therapy, with \\(89 \\%\\) of courses complicated by fever and \\(5.9 \\%\\) complicated by","confidence":1,"confidence_rate":1},{"cnt":[[1749,2608],[1880,2608],[1880,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":132,"height":46},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b89939f9f58142fa85cf37a77a64419b","type":"page_info","conversion_output":false,"text":"Page 20","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-021","page":21,"lines":[{"cnt":[[245,99],[614,99],[614,165],[245,165]],"region":{"top_left_x":244,"top_left_y":98,"width":371,"height":68},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"6282fe76ce2b4892b0b0864f209e0991","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,103],[1652,103],[1652,140],[653,140]],"region":{"top_left_x":653,"top_left_y":103,"width":1000,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"58d15338ff9e4e6387d6b7f94428d85a","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.6495842508738455,"confidence_rate":0.9946217307722369},{"cnt":[[1706,99],[1880,99],[1880,140],[1706,140]],"region":{"top_left_x":1705,"top_left_y":98,"width":175,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15ef698b76cc453eae5d226d1530c3a5","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[329,172],[655,172],[655,208],[329,208]],"region":{"top_left_x":328,"top_left_y":171,"width":328,"height":38},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"91ca7b617fe34b0480060b87455ff7c0","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,228],[1880,228],[1880,273],[245,273]],"region":{"top_left_x":244,"top_left_y":227,"width":1636,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89b8053044ee4511916b6980e7efa44c","type":"text","conversion_output":true,"text":"bacteremia. Median duration of neutropenia was 7 days (range \\(5-12\\) days); however, all patients recovered","text_display":"\nbacteremia. Median duration of neutropenia was 7 days (range \\(5-12\\) days); however, all patients recovered","confidence":0.7431640625,"confidence_rate":0.9974221245489857},{"cnt":[[245,271],[1880,271],[1880,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f3a73e22f48410d98f12c0ea723b334","type":"text","conversion_output":true,"text":"neutrophil count to \\(>1000 / \\mu l\\) and platelet to \\(75,000 / \\mu l\\) by 28 days. Nonhematologic toxicity was limited","text_display":" neutrophil count to \\(>1000 / \\mu l\\) and platelet to \\(75,000 / \\mu l\\) by 28 days. Nonhematologic toxicity was limited","confidence":0.99951171875,"confidence_rate":0.9999959967252418},{"cnt":[[245,316],[1880,316],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":315,"width":1636,"height":49},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bc3d13847f54e5293313701d9b4a593","type":"text","conversion_output":true,"text":"to Grade 4 hyperbilirubinemia and Grade 3 cardiac dysfunction in one patient during documented sepsis","text_display":" to Grade 4 hyperbilirubinemia and Grade 3 cardiac dysfunction in one patient during documented sepsis","confidence":1,"confidence_rate":1},{"cnt":[[245,361],[1880,361],[1880,404],[245,404]],"region":{"top_left_x":244,"top_left_y":360,"width":1636,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e05a9740a744efdbce1fd39b9253bd3","type":"text","conversion_output":true,"text":"and three episodes of Grade 3 mucositis, two associated with herpes simplex infection. There were no","text_display":" and three episodes of Grade 3 mucositis, two associated with herpes simplex infection. There were no","confidence":1,"confidence_rate":1},{"cnt":[[245,400],[1880,400],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":399,"width":1636,"height":51},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ae31c94fd4444e0a308dd0d4beea91f","type":"text","conversion_output":true,"text":"toxic deaths. Cyclophosphamide and topotecan doses of \\(1 gram / m ^{2} /\\) day for 3 days and 1.25 to 4","text_display":" toxic deaths. Cyclophosphamide and topotecan doses of \\(1 gram / m ^{2} /\\) day for 3 days and 1.25 to 4","confidence":0.932161808013916,"confidence_rate":0.9994048478037344},{"cnt":[[245,443],[1880,443],[1880,492],[245,492]],"region":{"top_left_x":244,"top_left_y":442,"width":1636,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bd1415ef61046a5af7aed4a64db2bc4","type":"text","conversion_output":true,"text":"\\(mg / m ^{2} /\\) day for 5 days have been successfully combined with melphalan as a myeloablative regimen for","text_display":" \\(mg / m ^{2} /\\) day for 5 days have been successfully combined with melphalan as a myeloablative regimen for","confidence":0.9951171875,"confidence_rate":0.9999588683049504},{"cnt":[[245,486],[1880,486],[1880,537],[245,537]],"region":{"top_left_x":244,"top_left_y":485,"width":1636,"height":53},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5bdc9a69c354d568713b9e10bca319c","type":"text","conversion_output":true,"text":"adult patients with advanced ovarian cancer. \\({ }^{54}\\) Non-hematopoietic toxicity was limited to mucositis with","text_display":" adult patients with advanced ovarian cancer. \\({ }^{54}\\) Non-hematopoietic toxicity was limited to mucositis with","confidence":1,"confidence_rate":1},{"cnt":[[245,535],[1291,535],[1291,580],[245,580]],"region":{"top_left_x":244,"top_left_y":534,"width":1048,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13d4b94beeea47e69dc3d58d140b6cb8","type":"text","conversion_output":true,"text":"maximum of Grade 2 toxicity occurring in 16 of 53 patients treated.","text_display":" maximum of Grade 2 toxicity occurring in 16 of 53 patients treated.","confidence":0.99951171875,"confidence_rate":0.9999939703823991},{"cnt":[[245,623],[1880,623],[1880,668],[245,668]],"region":{"top_left_x":244,"top_left_y":623,"width":1636,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"423cce9983114efabdd214063e814c3b","type":"text","conversion_output":true,"text":"The limited toxicity profile following dose-intensive administration of topotecan and cyclophosphamide","text_display":"\n\nThe limited toxicity profile following dose-intensive administration of topotecan and cyclophosphamide","confidence":1,"confidence_rate":1},{"cnt":[[245,666],[1880,666],[1880,711],[245,711]],"region":{"top_left_x":244,"top_left_y":666,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fad5a8644bd48ff9853fa42d884a963","type":"text","conversion_output":true,"text":"support the potential feasibility for its incorporation into an upfront induction regimen. To this end, COG","text_display":" support the potential feasibility for its incorporation into an upfront induction regimen. To this end, COG","confidence":1,"confidence_rate":1},{"cnt":[[245,709],[1880,709],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1636,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72258e4df77a404bb90275424e3b7f15","type":"text","conversion_output":true,"text":"ANBL02P1 examined the feasibility of adding dose intensive topotecan and cyclophosphamide onto the","text_display":" ANBL02P1 examined the feasibility of adding dose intensive topotecan and cyclophosphamide onto the","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1880,752],[1880,799],[245,799]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":49},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fabe457ffec44d5b3670664ad6d9d71","type":"text","conversion_output":true,"text":"N7 backbone chemotherapy administered in COG A3973 study. Escalated doses of topotecan (1.2","text_display":" N7 backbone chemotherapy administered in COG A3973 study. Escalated doses of topotecan (1.2","confidence":0.55419921875,"confidence_rate":0.993870621584055},{"cnt":[[245,793],[1880,793],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":792,"width":1636,"height":53},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d38985841fd54552a78dddfe3e2386aa","type":"text","conversion_output":true,"text":"\\(mg / m ^{2} /\\) day for 5 days) and cyclophosphamide ( \\(400 mg / m ^{2} /\\) day for 5 days) (T/C) replace the initial 2","text_display":" \\(mg / m ^{2} /\\) day for 5 days) and cyclophosphamide ( \\(400 mg / m ^{2} /\\) day for 5 days) (T/C) replace the initial 2","confidence":0.9825056468779694,"confidence_rate":0.9998711821094397},{"cnt":[[245,842],[1880,842],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":842,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c38da5601e8e414f9b1cd4793cc68397","type":"text","conversion_output":true,"text":"cycles of A3973 induction chemotherapy allowing incorporation of topotecan while maintaining dose","text_display":" cycles of A3973 induction chemotherapy allowing incorporation of topotecan while maintaining dose","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,885],[1882,885],[1882,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1639,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82f5d00b502043ff953f9e2bf47eef16","type":"text","conversion_output":true,"text":"intensity of known active agents in the treatment of neuroblastoma (see Table 2). The topotecan dose of","text_display":" intensity of known active agents in the treatment of neuroblastoma (see Table 2). The topotecan dose of","confidence":1,"confidence_rate":1},{"cnt":[[247,924],[1880,924],[1880,973],[247,973]],"region":{"top_left_x":247,"top_left_y":923,"width":1633,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"438455a07d1b4154a9a7b30d4d824375","type":"text","conversion_output":true,"text":"\\(1.2 mg / m ^{2} /\\) day \\(\\times 5\\) days was chosen based upon a predicted topotecan AUC ( \\(50-70 ng / mL\\) *hr) that is","text_display":" \\(1.2 mg / m ^{2} /\\) day \\(\\times 5\\) days was chosen based upon a predicted topotecan AUC ( \\(50-70 ng / mL\\) *hr) that is","confidence":0.3775025554009978,"confidence_rate":0.9921745061425407},{"cnt":[[245,969],[1880,969],[1880,1018],[245,1018]],"region":{"top_left_x":244,"top_left_y":968,"width":1636,"height":51},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d103ad5b31214c37a56920ad83670f87","type":"text","conversion_output":true,"text":"within the range known to produce tumor response in murine xenograft models \\({ }^{42}\\) and the ability to","text_display":" within the range known to produce tumor response in murine xenograft models \\({ }^{42}\\) and the ability to","confidence":1,"confidence_rate":1},{"cnt":[[245,1010],[1880,1010],[1880,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1009,"width":1636,"height":55},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de7d41a2aa7740c58722dae09824e8ea","type":"text","conversion_output":true,"text":"administer with cyclophosphamide. \\({ }^{53}\\) Chemotherapy cycles were scheduled every 21 days, PBSC harvest","text_display":" administer with cyclophosphamide. \\({ }^{53}\\) Chemotherapy cycles were scheduled every 21 days, PBSC harvest","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1880,1061],[1880,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca83b083c7864bfb94a747799dd304b5","type":"text","conversion_output":true,"text":"occurred after T/C cycles and surgical resection of residual primary tumor after cycle 5. Thirty-one","text_display":" occurred after T/C cycles and surgical resection of residual primary tumor after cycle 5. Thirty-one","confidence":0.72802734375,"confidence_rate":0.9969815487936854},{"cnt":[[245,1104],[1880,1104],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1104,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b263db36ecb24244ba5e22ec801cac9a","type":"text","conversion_output":true,"text":"patients, 3 with INSS Stage 3 and 28 with Stage 4 were enrolled. Pharmacokinetically guided topotecan","text_display":" patients, 3 with INSS Stage 3 and 28 with Stage 4 were enrolled. Pharmacokinetically guided topotecan","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1880,1147],[1880,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1147,"width":1636,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"273980f040e44819a00aa79936fd1891","type":"text","conversion_output":true,"text":"dosing (target systemic exposure of AUC \\(50-70 ng / ml ^{*} hr\\) determined by single day topotecan lactone","text_display":" dosing (target systemic exposure of AUC \\(50-70 ng / ml ^{*} hr\\) determined by single day topotecan lactone","confidence":0.7807365108747035,"confidence_rate":0.9979394794588962},{"cnt":[[245,1192],[1876,1192],[1876,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1192,"width":1632,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50d7167b69254696b45d91390f4d6651","type":"text","conversion_output":true,"text":"levels) demonstrated the ability to achieve the target AUC in \\(87 \\%(27 / 31)\\) of patients during T/C Cycle 1","text_display":" levels) demonstrated the ability to achieve the target AUC in \\(87 \\%(27 / 31)\\) of patients during T/C Cycle 1","confidence":1,"confidence_rate":1},{"cnt":[[245,1238],[1878,1238],[1878,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1237,"width":1634,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"038b754c2d0d48bf837002ce818a493e","type":"text","conversion_output":true,"text":"and in \\(85 \\%(23 / 27)\\) of patients during T/C Cycle 2. Furthermore, the median topotecan dose required to","text_display":" and in \\(85 \\%(23 / 27)\\) of patients during T/C Cycle 2. Furthermore, the median topotecan dose required to","confidence":0.9723601341247559,"confidence_rate":0.9997405055746507},{"cnt":[[245,1276],[1878,1276],[1878,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1276,"width":1634,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44b9e4ead3d14f2db601824625e11ab9","type":"text","conversion_output":true,"text":"achieve the targeted AUC during Cycle 1 and Cycle 2 was \\(1.2 mg / m ^{2} /\\) day and \\(1.3 mg / m ^{2} /\\) day ,","text_display":" achieve the targeted AUC during Cycle 1 and Cycle 2 was \\(1.2 mg / m ^{2} /\\) day and \\(1.3 mg / m ^{2} /\\) day ,","confidence":0.9863405227661133,"confidence_rate":0.9998988755088172},{"cnt":[[245,1319],[1880,1319],[1880,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1319,"width":1636,"height":52},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ac9ee92a83e4d8ea3ab8f13cdad0ef6","type":"text","conversion_output":true,"text":"respectively and support the use of \\(1.2 mg / m ^{2} /\\) day dosing in the ANBL0532 induction. Successful PBSC","text_display":" respectively and support the use of \\(1.2 mg / m ^{2} /\\) day dosing in the ANBL0532 induction. Successful PBSC","confidence":0.99853515625,"confidence_rate":0.9999877840939273},{"cnt":[[245,1364],[1880,1364],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1364,"width":1636,"height":52},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18e201b58ade4b1da28aa78505542f0c","type":"text","conversion_output":true,"text":"harvest as defined by a minimum of \\(2 \\times 10^{6}\\) CD34 cells/kg was achieved in \\(25 / 26\\) patients for whom data","text_display":" harvest as defined by a minimum of \\(2 \\times 10^{6}\\) CD34 cells/kg was achieved in \\(25 / 26\\) patients for whom data","confidence":0.3913446862743264,"confidence_rate":0.9920135449776415},{"cnt":[[245,1409],[1876,1409],[1876,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1409,"width":1632,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d2cceabf9c9417ba5e04c0a769999da","type":"text","conversion_output":true,"text":"are available; median harvest of \\(32.4 \\times 10^{6} CD 34\\) cells/kg (range 2.24-548) collected over a median of 1","text_display":" are available; median harvest of \\(32.4 \\times 10^{6} CD 34\\) cells/kg (range 2.24-548) collected over a median of 1","confidence":0.4423951607861909,"confidence_rate":0.9930537098540358},{"cnt":[[245,1452],[1880,1452],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1452,"width":1636,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9008a5e1dea7491d951110cf1a0a6e26","type":"text","conversion_output":true,"text":"day (range 1-3 days). A PBSC harvest of \\(>6 \\times 10^{6}\\) CD34 cells \\(/ kg\\) was achieved in 23 patients ( \\(88 \\%\\) ). One","text_display":" day (range 1-3 days). A PBSC harvest of \\(>6 \\times 10^{6}\\) CD34 cells \\(/ kg\\) was achieved in 23 patients ( \\(88 \\%\\) ). One","confidence":0.9146880114240048,"confidence_rate":0.9993089811661044},{"cnt":[[245,1500],[1880,1500],[1880,1545],[245,1545]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ce5d9692b5a47e38b766722a555d457","type":"text","conversion_output":true,"text":"patient was harvested after Cycle 5 due to physician discretion and achieved a PBSC collection of \\(1.8 \\times\\)","text_display":" patient was harvested after Cycle 5 due to physician discretion and achieved a PBSC collection of \\(1.8 \\times","confidence":0.9673008918762207,"confidence_rate":0.9996950403466458},{"cnt":[[247,1540],[1882,1540],[1882,1590],[247,1590]],"region":{"top_left_x":247,"top_left_y":1540,"width":1636,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9569333ed272441fbbfeb827ddb9ca04","type":"text","conversion_output":true,"text":"\\(10^{6}\\) CD34 cells/kg. Only one patient required 3 days of apheresis but achieved a total PBSC collection of","text_display":" 10^{6}\\) CD34 cells/kg. Only one patient required 3 days of apheresis but achieved a total PBSC collection of","confidence":0.9985356330871582,"confidence_rate":0.9999875810928277},{"cnt":[[245,1586],[1880,1586],[1880,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1585,"width":1636,"height":50},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2996a801a1b74e629764de168a1bd2b6","type":"text","conversion_output":true,"text":"\\(31.4 \\times 10^{6}\\) CD34 cells/kg. All PBSC collections were free of tumor contamination using an","text_display":" \\(31.4 \\times 10^{6}\\) CD34 cells/kg. All PBSC collections were free of tumor contamination using an","confidence":0.9345703125,"confidence_rate":0.9993026307580638},{"cnt":[[245,1633],[1882,1633],[1882,1678],[245,1678]],"region":{"top_left_x":244,"top_left_y":1632,"width":1639,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09b644212ad84fdab8f95f915960ca77","type":"text","conversion_output":true,"text":"immunocytochemical detection assay. There were no dose limiting toxicities during Cycles 1 and 2 of","text_display":" immunocytochemical detection assay. There were no dose limiting toxicities during Cycles 1 and 2 of","confidence":1,"confidence_rate":1},{"cnt":[[245,1676],[1880,1676],[1880,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1675,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e18fef00ba54af891b0c66500883adc","type":"text","conversion_output":true,"text":"induction and no induction related moralities. The majority of patients ( \\(85 \\%\\) ) experienced Grade 3 or 4","text_display":" induction and no induction related moralities. The majority of patients ( \\(85 \\%\\) ) experienced Grade 3 or 4","confidence":0.9980480668600649,"confidence_rate":0.999982861193853},{"cnt":[[245,1719],[1880,1719],[1880,1766],[245,1766]],"region":{"top_left_x":244,"top_left_y":1718,"width":1636,"height":49},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8eaf8a7be00b4a74833e02f689fbed29","type":"text","conversion_output":true,"text":"hematopoietic toxicity. Documented infection occurred in \\(10.3 \\%\\) patients during T/C cycles compared to","text_display":" hematopoietic toxicity. Documented infection occurred in \\(10.3 \\%\\) patients during T/C cycles compared to","confidence":0.607421875,"confidence_rate":0.9954367579325307},{"cnt":[[245,1764],[1880,1764],[1880,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1763,"width":1636,"height":49},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"539b7a7c18fd4fab903bdb17b2f6a1e1","type":"text","conversion_output":true,"text":"\\(26 \\%\\) of patients during subsequent induction cycles on ANBL02P1 or \\(30 \\%\\) patients during initial 3 cycles","text_display":" \\(26 \\%\\) of patients during subsequent induction cycles on ANBL02P1 or \\(30 \\%\\) patients during initial 3 cycles","confidence":0.94580078125,"confidence_rate":0.9995025940799293},{"cnt":[[245,1809],[1880,1809],[1880,1854],[245,1854]],"region":{"top_left_x":244,"top_left_y":1808,"width":1636,"height":47},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4720d168f6944c284b2dcf83cf46591","type":"text","conversion_output":true,"text":"of the MSKCC induction on COG A3973. The intended dose intensity of all chemotherapy agents was","text_display":" of the MSKCC induction on COG A3973. The intended dose intensity of all chemotherapy agents was","confidence":1,"confidence_rate":1},{"cnt":[[245,1852],[1880,1852],[1880,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1851,"width":1636,"height":47},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8a8282474af43628c78abd2bde03b38","type":"text","conversion_output":true,"text":"maintained in 30 of 31 patients. One patient required a \\(25 \\%\\) dose reduction of chemotherapy doses","text_display":" maintained in 30 of 31 patients. One patient required a \\(25 \\%\\) dose reduction of chemotherapy doses","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,1895],[1878,1895],[1878,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1894,"width":1634,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39ac9b941e0d49ce8507bfef389b0b5a","type":"text","conversion_output":true,"text":"during Cycle 6 induction due to prolonged myelosuppression. Complete response or partial response","text_display":" during Cycle 6 induction due to prolonged myelosuppression. Complete response or partial response","confidence":1,"confidence_rate":1},{"cnt":[[245,1942],[1880,1942],[1880,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1942,"width":1636,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e31b4948d93e446ebc10ea4c8a50a706","type":"text","conversion_output":true,"text":"was achieved in \\(36 \\%\\) of patients following 2 cycles of T/C. End-induction response rate (CR/VGPR) was","text_display":" was achieved in \\(36 \\%\\) of patients following 2 cycles of T/C. End-induction response rate (CR/VGPR) was","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,1985],[1880,1985],[1880,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1985,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ddbd7a4d7def4214adcee233cb398309","type":"text","conversion_output":true,"text":"\\(50 \\%\\) ( \\(13 / 26\\) ), 1 patient developed progressive disease following completion of induction but prior to","text_display":" \\(50 \\%\\) ( \\(13 / 26\\) ), 1 patient developed progressive disease following completion of induction but prior to","confidence":0.6049053049423492,"confidence_rate":0.9954815601394206},{"cnt":[[245,2024],[776,2024],[776,2073],[245,2073]],"region":{"top_left_x":244,"top_left_y":2023,"width":532,"height":51},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc77f2cbe02d4d499cc1b04d8e6b9a78","type":"text","conversion_output":true,"text":"initiating consolidation therapy. \\({ }^{55}\\)","text_display":" initiating consolidation therapy. \\({ }^{55}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,2114],[1880,2114],[1880,2161],[245,2161]],"region":{"top_left_x":244,"top_left_y":2114,"width":1636,"height":48},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79464507357d4fa182eea877efafa441","type":"text","conversion_output":true,"text":"In summary, this dose intensive cyclophosphamide and topotecan containing induction regimen was well","text_display":"\n\nIn summary, this dose intensive cyclophosphamide and topotecan containing induction regimen was well","confidence":1,"confidence_rate":1},{"cnt":[[245,2159],[1880,2159],[1880,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2159,"width":1636,"height":48},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29c712ffe2644e69b25e0f8527a27d5c","type":"text","conversion_output":true,"text":"tolerated with expected and reversible toxicities. Dose intensity of standard induction chemotherapy","text_display":" tolerated with expected and reversible toxicities. Dose intensity of standard induction chemotherapy","confidence":1,"confidence_rate":1},{"cnt":[[245,2204],[1880,2204],[1880,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2204,"width":1636,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"531f50b92c9c49428876e2daeeff8126","type":"text","conversion_output":true,"text":"agents was not limited by the addition of dose-intensive topotecan. The ability to achieve sufficient PBSC","text_display":" agents was not limited by the addition of dose-intensive topotecan. The ability to achieve sufficient PBSC","confidence":1,"confidence_rate":1},{"cnt":[[245,2247],[1882,2247],[1882,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2247,"width":1639,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6fa7c38f04d48219dbd486c8d0e1650","type":"text","conversion_output":true,"text":"harvest with in vivo tumor purging was demonstrated. Together these data support the investigation of","text_display":" harvest with in vivo tumor purging was demonstrated. Together these data support the investigation of","confidence":1,"confidence_rate":1},{"cnt":[[245,2290],[1104,2290],[1104,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2290,"width":861,"height":50},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c29350dbdaff4d8088c4eadc048e0b89","type":"text","conversion_output":true,"text":"efficacy of this novel induction regimen in ANBL0532.","text_display":" efficacy of this novel induction regimen in ANBL0532.","confidence":1,"confidence_rate":1},{"cnt":[[1749,2608],[1876,2608],[1876,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":128,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51a4b5ed26054f47ac8c7979995c44b7","type":"page_info","conversion_output":false,"text":"Page 21","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-022","page":22,"lines":[{"cnt":[[247,99],[614,99],[614,165],[247,165]],"region":{"top_left_x":247,"top_left_y":98,"width":368,"height":68},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"480d9d67cecb4c12bc3d0531ea7b0010","type":"page_info","conversion_output":false,"text":"","text_display":""},{"cnt":[[653,107],[1648,107],[1648,140],[653,140]],"region":{"top_left_x":653,"top_left_y":107,"width":995,"height":33},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a22837249aa5403495fa272b060355a9","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.9791296018192952,"confidence_rate":0.9997363939579867},{"cnt":[[1708,103],[1876,103],[1876,135],[1708,135]],"region":{"top_left_x":1708,"top_left_y":103,"width":168,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6573624b235429fa8f61e270cecef01","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,176],[651,176],[651,208],[331,208]],"region":{"top_left_x":330,"top_left_y":176,"width":321,"height":33},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8a3b656276cb4f559ebc99b2a0636b73","type":"text","conversion_output":true,"text":"Children's Oncology Group","text_display":"\n\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[245,228],[1502,228],[1502,273],[245,273]],"region":{"top_left_x":244,"top_left_y":227,"width":1258,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f67260cf37845a9b7fd263d1fddf810","type":"figure_label","conversion_output":false,"text":"TABLE 2. 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The dose intensity of carboplatin is calculated in","confidence":0.576866626739502,"confidence_rate":0.9950560080082831},{"cnt":[[370,1040],[1852,1040],[1852,1085],[370,1085]],"region":{"top_left_x":369,"top_left_y":1039,"width":1483,"height":46},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a26c32775ba84e7ab0a4c8746ce22f71","type":"text","conversion_output":true,"text":"cisplatin equivalent using a conversion of 4 mg carboplatin is biologically equivalent to 1 mg of","text_display":" cisplatin equivalent using a conversion of 4 mg carboplatin is biologically equivalent to 1 mg of","confidence":1,"confidence_rate":1},{"cnt":[[370,1083],[518,1083],[518,1128],[370,1128]],"region":{"top_left_x":369,"top_left_y":1082,"width":149,"height":46},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b36b09d94984485b895977e39f371de4","type":"text","conversion_output":true,"text":"cisplatin.","text_display":" cisplatin.","confidence":1,"confidence_rate":1},{"cnt":[[241,1164],[793,1164],[793,1218],[241,1218]],"region":{"top_left_x":240,"top_left_y":1164,"width":553,"height":55},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50d730aea1524c7c86a461da02195e6a","type":"section_header","conversion_output":false,"children_ids":["cb50abc7a9914f73950637c318677059"],"text":"","text_display":""},{"cnt":[[245,1171],[788,1171],[788,1214],[245,1214]],"region":{"top_left_x":244,"top_left_y":1170,"width":545,"height":44},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb50abc7a9914f73950637c318677059","type":"text","conversion_output":true,"parent_id":"50d730aea1524c7c86a461da02195e6a","text":"2.8 Local Radiation Therapy","text_display":"\n\n\\subsection*{2.8 Local Radiation Therapy}","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1880,1216],[1880,1257],[245,1257]],"region":{"top_left_x":244,"top_left_y":1216,"width":1636,"height":41},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0a61e5bddd349ffb4aca2e73d8586b1","type":"text","conversion_output":true,"text":"For stage III and IV neuroblastoma, local relapse is a major component of treatment failure in several","text_display":"\n\nFor stage III and IV neuroblastoma, local relapse is a major component of treatment failure in several","confidence":1,"confidence_rate":1},{"cnt":[[245,1250],[1880,1250],[1880,1302],[245,1302]],"region":{"top_left_x":244,"top_left_y":1250,"width":1636,"height":52},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81e44b24732d4b2b9a530acda6b0b941","type":"text","conversion_output":true,"text":"published series, all of which included radiation delivered to the site of primary disease. \\({ }^{57-59}\\) As systemic","text_display":" published series, all of which included radiation delivered to the site of primary disease. \\({ }^{57-59}\\) As systemic","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[1880,1302],[1880,1347],[245,1347]],"region":{"top_left_x":244,"top_left_y":1301,"width":1636,"height":47},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ea81961ee4d40c3a7d28b81d15e787e","type":"text","conversion_output":true,"text":"therapy for high-risk neuroblastoma becomes more aggressive, response rates improve, and survival","text_display":" therapy for high-risk neuroblastoma becomes more aggressive, response rates improve, and survival","confidence":1,"confidence_rate":1},{"cnt":[[245,1345],[1878,1345],[1878,1390],[245,1390]],"region":{"top_left_x":244,"top_left_y":1344,"width":1634,"height":47},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40eaa1527c4f435da198defa97c251d8","type":"text","conversion_output":true,"text":"increases, local control becomes a formidable problem. This is evident in a recent analysis of CCG 3891,","text_display":" increases, local control becomes a formidable problem. This is evident in a recent analysis of CCG 3891,","confidence":1,"confidence_rate":1},{"cnt":[[245,1388],[1880,1388],[1880,1433],[245,1433]],"region":{"top_left_x":244,"top_left_y":1387,"width":1636,"height":47},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba122e2ca4fd4bc6b28cca5fcaf6bfbb","type":"text","conversion_output":true,"text":"consisting of chemotherapy, primary surgery, 10 Gy of external beam radiation therapy (EBRT) to gross","text_display":" consisting of chemotherapy, primary surgery, 10 Gy of external beam radiation therapy (EBRT) to gross","confidence":0.99365234375,"confidence_rate":0.9999415807130537},{"cnt":[[245,1433],[1880,1433],[1880,1476],[245,1476]],"region":{"top_left_x":244,"top_left_y":1433,"width":1636,"height":43},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f98e631a34d44d1bf6facb322962ea6","type":"text","conversion_output":true,"text":"residual disease, followed by randomized assignment to continuation chemotherapy (CC) or autologous","text_display":" residual disease, followed by randomized assignment to continuation chemotherapy (CC) or autologous","confidence":1,"confidence_rate":1},{"cnt":[[245,1474],[1878,1474],[1878,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1473,"width":1634,"height":51},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28185548f0c043e59c631c2d8e6d13e0","type":"text","conversion_output":true,"text":"bone marrow transplantation (ABMT). \\({ }^{8}\\) ABMT patients received 10 Gy of total body irradiation (TBI).","text_display":" bone marrow transplantation (ABMT). \\({ }^{8}\\) ABMT patients received 10 Gy of total body irradiation (TBI).","confidence":0.99951171875,"confidence_rate":0.999995825645481},{"cnt":[[245,1521],[1880,1521],[1880,1566],[245,1566]],"region":{"top_left_x":244,"top_left_y":1521,"width":1636,"height":46},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fdc8ef2ac89541dfbf649eeedec4d63c","type":"text","conversion_output":true,"text":"Estimated 5-year locoregional recurrence rates were \\(51 \\% \\pm 5 \\%\\) and \\(33 \\% \\pm 7 \\%\\) for CC and ABMT","text_display":" Estimated 5-year locoregional recurrence rates were \\(51 \\% \\pm 5 \\%\\) and \\(33 \\% \\pm 7 \\%\\) for CC and ABMT","confidence":0.9560966491699219,"confidence_rate":0.9995324398238565},{"cnt":[[245,1564],[1882,1564],[1882,1609],[245,1609]],"region":{"top_left_x":244,"top_left_y":1564,"width":1639,"height":46},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fd600b5f30f43c486b993d056bbec8e","type":"text","conversion_output":true,"text":"patients, respectively \\(( P =0.004)\\). Results of this trial revealed that for patients who received 10 Gy of","text_display":" patients, respectively \\(( P =0.004)\\). Results of this trial revealed that for patients who received 10 Gy of","confidence":0.721703052520752,"confidence_rate":0.9972630672963159},{"cnt":[[245,1609],[1880,1609],[1880,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":1609,"width":1636,"height":44},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45235c7e49154ccf8c125fa653521c65","type":"text","conversion_output":true,"text":"EBRT to the primary, the addition of 10 Gy of TBI and ABMT decreased local recurrence compared with","text_display":" EBRT to the primary, the addition of 10 Gy of TBI and ABMT decreased local recurrence compared with","confidence":1,"confidence_rate":1},{"cnt":[[245,1652],[1880,1652],[1880,1697],[245,1697]],"region":{"top_left_x":244,"top_left_y":1652,"width":1636,"height":46},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e9b622ee1ef4b808fd57f1decda4075","type":"text","conversion_output":true,"text":"\\(CC (22 \\% \\pm 12 \\%\\) and \\(52 \\% \\pm 8 \\%, P =0.022)\\). This indicates that in combination with EBRT to the primary","text_display":" \\(CC (22 \\% \\pm 12 \\%\\) and \\(52 \\% \\pm 8 \\%, P =0.022)\\). This indicates that in combination with EBRT to the primary","confidence":0.7140733869746327,"confidence_rate":0.9967978090416361},{"cnt":[[245,1697],[1878,1697],[1878,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1697,"width":1634,"height":46},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ffa4f1fb7714786a7c98872f4ed0ab6","type":"text","conversion_output":true,"text":"tumors site, the addition of 10 Gy of TBI as a component of high dose chemotherapy with ABMT","text_display":" tumors site, the addition of 10 Gy of TBI as a component of high dose chemotherapy with ABMT","confidence":1,"confidence_rate":1},{"cnt":[[245,1740],[1880,1740],[1880,1785],[245,1785]],"region":{"top_left_x":244,"top_left_y":1740,"width":1636,"height":46},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4b0a805f4264f878d540aeaed27c631","type":"text","conversion_output":true,"text":"improved local control compared with CC without TBI. Several single institution reports further support","text_display":" improved local control compared with CC without TBI. Several single institution reports further support","confidence":1,"confidence_rate":1},{"cnt":[[245,1783],[1880,1783],[1880,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1783,"width":1636,"height":46},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27e91daf1634472ca689259bcadc488e","type":"text","conversion_output":true,"text":"the administration of pre-chemotherapy or pre-surgery primary tumor volume and regional lymph nodes","text_display":" the administration of pre-chemotherapy or pre-surgery primary tumor volume and regional lymph nodes","confidence":1,"confidence_rate":1},{"cnt":[[245,1822],[1880,1822],[1880,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1821,"width":1636,"height":55},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13f86cd5372043f3a851f0fd51fb7328","type":"text","conversion_output":true,"text":"primary site radiation therapy ( 21 Gy) results in improved local tumor control. \\({ }^{60-62}\\) Based upon these data,","text_display":" primary site radiation therapy ( 21 Gy) results in improved local tumor control. \\({ }^{60-62}\\) Based upon these data,","confidence":0.7843894958496094,"confidence_rate":0.9980896257059313},{"cnt":[[245,1873],[1880,1873],[1880,1916],[245,1916]],"region":{"top_left_x":244,"top_left_y":1873,"width":1636,"height":44},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6015e1142114184b81a9f706b825aea","type":"text","conversion_output":true,"text":"the currently completed COG A3973 delivered 21.6 Gy EBRT to pre-surgical primary tumor volume","text_display":" the currently completed COG A3973 delivered 21.6 Gy EBRT to pre-surgical primary tumor volume","confidence":0.97607421875,"confidence_rate":0.9997529218384398},{"cnt":[[245,1916],[1205,1916],[1205,1962],[245,1962]],"region":{"top_left_x":244,"top_left_y":1916,"width":962,"height":46},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1585fc8692264a368fca8e0bfe80fe63","type":"text","conversion_output":true,"text":"following recovery from consolidation myeloablative therapy.","text_display":" following recovery from consolidation myeloablative therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,2002],[1880,2002],[1880,2047],[245,2047]],"region":{"top_left_x":244,"top_left_y":2002,"width":1636,"height":46},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0219951b4aeb4f0b929eaeaeb7bd0242","type":"text","conversion_output":true,"text":"Several analyses of outcome for high-risk neuroblastoma suggest that current local therapy for","text_display":"\n\nSeveral analyses of outcome for high-risk neuroblastoma suggest that current local therapy for","confidence":1,"confidence_rate":1},{"cnt":[[245,2047],[1880,2047],[1880,2093],[245,2093]],"region":{"top_left_x":244,"top_left_y":2047,"width":1636,"height":46},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"771cec7645fe497081b30fc47dc6ca86","type":"text","conversion_output":true,"text":"incompletely resected patients is inadequate. Wolden et al. reported on a series of patients with stage 4","text_display":" incompletely resected patients is inadequate. Wolden et al. reported on a series of patients with stage 4","confidence":0.99609375,"confidence_rate":0.9999640933114391},{"cnt":[[245,2093],[1880,2093],[1880,2138],[245,2138]],"region":{"top_left_x":244,"top_left_y":2092,"width":1636,"height":46},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5680c65206f845d1908289c0ff27b083","type":"text","conversion_output":true,"text":"neuroblastoma receiving 1.5 Gy twice a day to 21 Gy to pre chemotherapy, pre-surgery primary tumor","text_display":" neuroblastoma receiving 1.5 Gy twice a day to 21 Gy to pre chemotherapy, pre-surgery primary tumor","confidence":1,"confidence_rate":1},{"cnt":[[245,2131],[1880,2131],[1880,2181],[245,2181]],"region":{"top_left_x":244,"top_left_y":2131,"width":1636,"height":50},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"140960adbd21455aa27e6f0a809e5fa6","type":"text","conversion_output":true,"text":"volume and regional lymph nodes. \\({ }^{60}\\) The actuarial locoregional control rate at 5 years was \\(84 \\%\\). A recent","text_display":" volume and regional lymph nodes. \\({ }^{60}\\) The actuarial locoregional control rate at 5 years was \\(84 \\%\\). A recent","confidence":1,"confidence_rate":1},{"cnt":[[245,2179],[1882,2179],[1882,2224],[245,2224]],"region":{"top_left_x":244,"top_left_y":2178,"width":1639,"height":46},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c35a6256c09d4279873162a670d33fdc","type":"text","conversion_output":true,"text":"update of this experience reported a \\(10.1 \\%\\) probability of primary-site failure among 99 patients, most of","text_display":" update of this experience reported a \\(10.1 \\%\\) probability of primary-site failure among 99 patients, most of","confidence":0.9931755065917969,"confidence_rate":0.9999409682359266},{"cnt":[[245,2221],[1880,2221],[1880,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2221,"width":1636,"height":50},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a8e047857934a089a2d7b17d11be061","type":"text","conversion_output":true,"text":"whom ( 92 patients) had no evidence of disease in the primary site at the time of irradiation. \\({ }^{61}\\) Among","text_display":" whom ( 92 patients) had no evidence of disease in the primary site at the time of irradiation. \\({ }^{61}\\) Among","confidence":0.99951171875,"confidence_rate":0.9999959636403931},{"cnt":[[245,2269],[1880,2269],[1880,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2268,"width":1636,"height":46},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"288ccd31cbd34ee7a22199c75ac02e3d","type":"text","conversion_output":true,"text":"seven patients with disease at the primary site at the time of irradiation, three had disease that recurred","text_display":" seven patients with disease at the primary site at the time of irradiation, three had disease that recurred","confidence":1,"confidence_rate":1},{"cnt":[[245,2312],[1880,2312],[1880,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2311,"width":1636,"height":46},"line":105,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3bcce545753e427b945a15940b533f6d","type":"text","conversion_output":true,"text":"locally. EBRT did not increase acute toxicity, except for increased total parenteral nutrition","text_display":" locally. EBRT did not increase acute toxicity, except for increased total parenteral nutrition","confidence":1,"confidence_rate":1},{"cnt":[[245,2355],[483,2355],[483,2396],[245,2396]],"region":{"top_left_x":244,"top_left_y":2354,"width":240,"height":42},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9eac815ecc0042bbbd7662f3cb0910c8","type":"text","conversion_output":true,"text":"administration.","text_display":" administration.","confidence":1,"confidence_rate":1},{"cnt":[[245,2445],[1880,2445],[1880,2488],[245,2488]],"region":{"top_left_x":244,"top_left_y":2444,"width":1636,"height":44},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea8f5968319848e7b7c0968549ed6ddf","type":"text","conversion_output":true,"text":"Published studies have sought to assess the appropriate radiation dose to achieve local control in patients","text_display":"\n\nPublished studies have sought to assess the appropriate radiation dose to achieve local control in patients","confidence":1,"confidence_rate":1},{"cnt":[[245,2484],[1878,2484],[1878,2533],[245,2533]],"region":{"top_left_x":244,"top_left_y":2483,"width":1634,"height":51},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e22a3016a784d78bfa5f1ad294360d8","type":"text","conversion_output":true,"text":"with neuroblastoma. A dose response to radiation is supported by several publications; \\({ }^{58,63,64}\\) however,","text_display":" with neuroblastoma. A dose response to radiation is supported by several publications; \\({ }^{58,63,64}\\) however,","confidence":1,"confidence_rate":1},{"cnt":[[245,2531],[1876,2531],[1876,2576],[245,2576]],"region":{"top_left_x":244,"top_left_y":2530,"width":1632,"height":46},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1277e632b4a54e64939ecd803959f4af","type":"text","conversion_output":true,"text":"these publications describe results in stage III disease or do not incorporate biological prognostic markers.","text_display":" these publications describe results in stage III disease or do not incorporate biological prognostic markers.","confidence":1,"confidence_rate":1},{"cnt":[[1749,2608],[1876,2608],[1876,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":128,"height":46},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99c98a3ebd5e402a953adaa4025d80c7","type":"page_info","conversion_output":false,"text":"Page 22","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-023","page":23,"lines":[{"cnt":[[245,99],[614,99],[614,165],[245,165]],"region":{"top_left_x":244,"top_left_y":98,"width":371,"height":68},"line":1,"column":0,"font_size":70,"is_printed":true,"is_handwritten":false,"id":"dd82b311270740cbb42ba8c5a644f4a4","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,103],[1652,103],[1652,140],[653,140]],"region":{"top_left_x":653,"top_left_y":103,"width":1000,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"eb22d1ea8a8a474b85c1242f7b578534","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.6495842508738455,"confidence_rate":0.9946217307722369},{"cnt":[[1706,99],[1880,99],[1880,140],[1706,140]],"region":{"top_left_x":1705,"top_left_y":98,"width":175,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42327c9b481a4764b42de7f38b4c7e41","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[327,168],[655,168],[655,211],[327,211]],"region":{"top_left_x":326,"top_left_y":167,"width":330,"height":44},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"64a3c9f23ac847f29eadc3e1c7971cd4","type":"authors","conversion_output":false,"children_ids":["b2dc2216ffde44d5ba798bb49d1a0c80"],"text":"","text_display":""},{"cnt":[[331,172],[651,172],[651,208],[331,208]],"region":{"top_left_x":330,"top_left_y":171,"width":321,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b2dc2216ffde44d5ba798bb49d1a0c80","type":"text","conversion_output":true,"parent_id":"64a3c9f23ac847f29eadc3e1c7971cd4","text":"Children's Oncology Group","text_display":"\n\n\\author{\nChildren's Oncology Group\n}","confidence":1,"confidence_rate":1},{"cnt":[[245,228],[1880,228],[1880,273],[245,273]],"region":{"top_left_x":244,"top_left_y":227,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"729c9baf70c340d88dec081c647a03b7","type":"text","conversion_output":true,"text":"In the analysis of radiation therapy in CCG 3891, in combination with EBRT to the primary tumors site,","text_display":"\n\nIn the analysis of radiation therapy in CCG 3891, in combination with EBRT to the primary tumors site,","confidence":1,"confidence_rate":1},{"cnt":[[245,271],[1880,271],[1880,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":1636,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b6b87a439914bb78cb3ad97a3e9ee6e","type":"text","conversion_output":true,"text":"the addition of 10 Gy total body irradiation (TBI) as a component of autologous bone marrow transplant","text_display":" the addition of 10 Gy total body irradiation (TBI) as a component of autologous bone marrow transplant","confidence":0.99462890625,"confidence_rate":0.9999510414718479},{"cnt":[[245,314],[1880,314],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":313,"width":1636,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"364f117e234e46349b3a622ab7c0127f","type":"text","conversion_output":true,"text":"(ABMT) improved local control compared with continuation chemotherapy (CC) without TBI. In","text_display":" (ABMT) improved local control compared with continuation chemotherapy (CC) without TBI. In","confidence":1,"confidence_rate":1},{"cnt":[[245,361],[1880,361],[1880,406],[245,406]],"region":{"top_left_x":244,"top_left_y":360,"width":1636,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab4a1432938f4679baf533d62df912da","type":"text","conversion_output":true,"text":"addition, a dose response to radiation administered to the primary tumor site is supported by the patients","text_display":" addition, a dose response to radiation administered to the primary tumor site is supported by the patients","confidence":1,"confidence_rate":1},{"cnt":[[245,404],[1880,404],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":403,"width":1636,"height":47},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2a04d69f6be416581fcb2f66b99180a","type":"text","conversion_output":true,"text":"in this study that received 20 Gy for extra-abdominal primary tumors. Of 36 patients with extra-","text_display":" in this study that received 20 Gy for extra-abdominal primary tumors. Of 36 patients with extra","confidence":1,"confidence_rate":1},{"cnt":[[245,447],[1880,447],[1880,492],[245,492]],"region":{"top_left_x":244,"top_left_y":446,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a744d9e1ac304cbab5faac639eac4f4f","type":"text","conversion_output":true,"text":"abdominal primaries, 6 patients received 20 Gy EBRT (2 also received TBI) while 30 patients received no","text_display":"abdominal primaries, 6 patients received 20 Gy EBRT (2 also received TBI) while 30 patients received no","confidence":0.7607421875,"confidence_rate":0.9976654578414648},{"cnt":[[245,492],[1880,492],[1880,539],[245,539]],"region":{"top_left_x":244,"top_left_y":491,"width":1636,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4de25ca23f764c848f3d21b75b257ab4","type":"text","conversion_output":true,"text":"EBRT (10 of these received TBI). Local relapse rates at 5 years were \\(0 \\% \\pm 0 \\%\\) and \\(44 \\% \\pm 15 \\%\\) for","text_display":" EBRT (10 of these received TBI). Local relapse rates at 5 years were \\(0 \\% \\pm 0 \\%\\) and \\(44 \\% \\pm 15 \\%\\) for","confidence":0.9619140625,"confidence_rate":0.9996267027271238},{"cnt":[[245,533],[1880,533],[1880,587],[245,587]],"region":{"top_left_x":244,"top_left_y":532,"width":1636,"height":55},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27ab454c716444e988fd371b752524e7","type":"text","conversion_output":true,"text":"patients with and without EBRT, respectively \\(( P =0.09) .^{8}\\) Jacobson et al. reported on the experience at the","text_display":" patients with and without EBRT, respectively \\(( P =0.09) .^{8}\\) Jacobson et al. reported on the experience at the","confidence":0.5762017368651868,"confidence_rate":0.9955279365645027},{"cnt":[[245,580],[1880,580],[1880,627],[245,627]],"region":{"top_left_x":244,"top_left_y":580,"width":1636,"height":48},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be5cde55a4394ac68dbdd632db0b900f","type":"text","conversion_output":true,"text":"University of Florida, using radiation doses up to 45 Gy. The authors noted no evaluable complications","text_display":" University of Florida, using radiation doses up to 45 Gy. The authors noted no evaluable complications","confidence":0.9459521159296855,"confidence_rate":0.999495006382931},{"cnt":[[245,621],[1880,621],[1880,672],[245,672]],"region":{"top_left_x":244,"top_left_y":620,"width":1636,"height":53},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a1576577142423199b1dd7315432bb3","type":"text","conversion_output":true,"text":"related to radiation alone, but rather related more commonly to the tumor itself or surgical resection. \\({ }^{65}\\)","text_display":" related to radiation alone, but rather related more commonly to the tumor itself or surgical resection. \\({ }^{65}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,670],[1880,670],[1880,715],[245,715]],"region":{"top_left_x":244,"top_left_y":670,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e8c9490f2ea4fa9a0ee81c059fa91cb","type":"text","conversion_output":true,"text":"Investigators at the University of Utah performed a similar analysis of radiation dose response for","text_display":" Investigators at the University of Utah performed a similar analysis of radiation dose response for","confidence":1,"confidence_rate":1},{"cnt":[[245,713],[1880,713],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":713,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ab031268f7f48088be1548a6e321d3f","type":"text","conversion_output":true,"text":"neuroblastoma. The authors observed local failures after doses up to 45 Gy in children older than three","text_display":" neuroblastoma. The authors observed local failures after doses up to 45 Gy in children older than three","confidence":0.9975600242614746,"confidence_rate":0.9999779916175905},{"cnt":[[245,752],[1880,752],[1880,804],[245,804]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":53},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d76785c25af44e8a8426b175f7afb79","type":"text","conversion_output":true,"text":"years. \\({ }^{65}\\) Although authors of both studies state that doses lower than 45 Gy may be adequate for some","text_display":" years. \\({ }^{65}\\) Although authors of both studies state that doses lower than 45 Gy may be adequate for some","confidence":0.9975595474243164,"confidence_rate":0.9999794671407691},{"cnt":[[245,799],[1880,799],[1880,849],[245,849]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":50},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8baf598c6894d3db0a08ecddfd6905b","type":"text","conversion_output":true,"text":"patients with neuroblastoma, the vast minority of patients in these studies had high-risk disease and","text_display":" patients with neuroblastoma, the vast minority of patients in these studies had high-risk disease and","confidence":1,"confidence_rate":1},{"cnt":[[245,846],[1880,846],[1880,892],[245,892]],"region":{"top_left_x":244,"top_left_y":846,"width":1636,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1eb74abdac4e44ce8cd32b12069ec859","type":"text","conversion_output":true,"text":"therefore no firm conclusions can be drawn regarding the appropriate dose to the primary site in patients","text_display":" therefore no firm conclusions can be drawn regarding the appropriate dose to the primary site in patients","confidence":0.99560546875,"confidence_rate":0.9999599624780234},{"cnt":[[245,889],[1880,889],[1880,935],[245,935]],"region":{"top_left_x":244,"top_left_y":889,"width":1636,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9e637f41c7d4009aeab9155503f6e9e","type":"text","conversion_output":true,"text":"with high-risk disease. In fact, a recent abstract from the University Children's Hospital in Cologne,","text_display":" with high-risk disease. In fact, a recent abstract from the University Children's Hospital in Cologne,","confidence":1,"confidence_rate":1},{"cnt":[[245,932],[1880,932],[1880,982],[245,982]],"region":{"top_left_x":244,"top_left_y":932,"width":1636,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af8f67fefcf8492a802ed71ebea7f1f5","type":"text","conversion_output":true,"text":"Germany, reported that 36 Gy of external beam radiation therapy (EBRT) administered to patients with","text_display":" Germany, reported that 36 Gy of external beam radiation therapy (EBRT) administered to patients with","confidence":1,"confidence_rate":1},{"cnt":[[245,975],[1880,975],[1880,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":975,"width":1636,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a9ac740f2764392b69cd13f8a905136","type":"text","conversion_output":true,"text":"incompletely resected primary tumors could compensate for \"the disadvantage of incomplete response to","text_display":" incompletely resected primary tumors could compensate for \"the disadvantage of incomplete response to","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,1021],[1880,1021],[1880,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1020,"width":1636,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6321992970894d9e882721c44bf2887a","type":"text","conversion_output":true,"text":"induction chemotherapy.\" In this report of the NB97 trial for patients one year of age or older with stage","text_display":" induction chemotherapy.\" In this report of the NB97 trial for patients one year of age or older with stage","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1880,1061],[1880,1111],[245,1111]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ebd7e7596c545cdb37fc32b983e37f3","type":"text","conversion_output":true,"text":"4 neuroblastoma, patients with isolated localized residual disease had improved outcome following EBRT","text_display":" 4 neuroblastoma, patients with isolated localized residual disease had improved outcome following EBRT","confidence":1,"confidence_rate":1},{"cnt":[[245,1109],[1880,1109],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1108,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f97ae4de16ac4df2a6bcec801392ffad","type":"text","conversion_output":true,"text":"( 3 -y-EFS 100\\%, 3-y-OS 100\\%) compared those not receiving EBRT despite residual tumor tissue ( 3 -y-","text_display":" ( 3 -y-EFS 100\\%, 3-y-OS 100\\%) compared those not receiving EBRT despite residual tumor tissue ( 3 -y","confidence":0.7098339237817195,"confidence_rate":0.9969446392291061},{"cnt":[[245,1147],[1068,1147],[1068,1199],[245,1199]],"region":{"top_left_x":244,"top_left_y":1147,"width":824,"height":52},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e2b915c871047b28cec3d50793e6b3d","type":"text","conversion_output":true,"text":"EFS \\(20 \\pm 18 \\%\\), p<0.001; 3-y-OS \\(20 \\pm 18 \\%\\), p<0.001). \\({ }^{66}\\)","text_display":"EFS \\(20 \\pm 18 \\%\\), p<0.001; 3-y-OS \\(20 \\pm 18 \\%\\), p<0.001). \\({ }^{66}\\)","confidence":0.37027857259333113,"confidence_rate":0.9852810455260581},{"cnt":[[245,1240],[1880,1240],[1880,1287],[245,1287]],"region":{"top_left_x":244,"top_left_y":1239,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"247e022b39bd44cc88f1e3b46af671b9","type":"text","conversion_output":true,"text":"Given the high rates of local recurrence, particularly following an incomplete surgical resection, and the","text_display":"\n\nGiven the high rates of local recurrence, particularly following an incomplete surgical resection, and the","confidence":1,"confidence_rate":1},{"cnt":[[245,1285],[1880,1285],[1880,1330],[245,1330]],"region":{"top_left_x":244,"top_left_y":1284,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0be81e7e612c4e5cbf7233baa42d5040","type":"text","conversion_output":true,"text":"tolerable toxicity of EBRT evident in multi-institutional trials, patients enrolled onto ANBL0532 who","text_display":" tolerable toxicity of EBRT evident in multi-institutional trials, patients enrolled onto ANBL0532 who","confidence":0.9912109375,"confidence_rate":0.999916721259154},{"cnt":[[245,1328],[1880,1328],[1880,1373],[245,1373]],"region":{"top_left_x":244,"top_left_y":1327,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"965df1eae5e34a2da0744dacfb757b0c","type":"text","conversion_output":true,"text":"have an incomplete surgical resection of the primary tumor will receive 21.6 Gy EBRT to the post-","text_display":" have an incomplete surgical resection of the primary tumor will receive 21.6 Gy EBRT to the post","confidence":0.9833984375,"confidence_rate":0.999840575443913},{"cnt":[[245,1371],[1880,1371],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1370,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b93cd4527bf1473693ed824f4b3f604f","type":"text","conversion_output":true,"text":"induction chemotherapy, pre-operative primary tumor volume and an additional boost of 14.4 Gy EBRT","text_display":"induction chemotherapy, pre-operative primary tumor volume and an additional boost of 14.4 Gy EBRT","confidence":0.85595703125,"confidence_rate":0.9984910900245372},{"cnt":[[245,1414],[1882,1414],[1882,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1413,"width":1639,"height":51},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dfb00e99b3344ccabf30867bc30893c","type":"text","conversion_output":true,"text":"to the gross residual volume (total dose 36 Gy to gross residual tumor volume). The additional dose of","text_display":" to the gross residual volume (total dose 36 Gy to gross residual tumor volume). The additional dose of","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[247,1457],[1880,1457],[1880,1506],[247,1506]],"region":{"top_left_x":247,"top_left_y":1456,"width":1633,"height":51},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29a45a0677b34aa4a5be61d0a90da5c3","type":"text","conversion_output":true,"text":"14.4 Gy to gross residual disease is unlikely to result in significantly increased toxicities. In CCG 3891,","text_display":" 14.4 Gy to gross residual disease is unlikely to result in significantly increased toxicities. In CCG 3891,","confidence":1,"confidence_rate":1},{"cnt":[[245,1504],[1880,1504],[1880,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1503,"width":1636,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e35c588db5ac4a25b1bae30372ac0538","type":"text","conversion_output":true,"text":"the administration of EBRT was not associated with enhanced toxicities with the exception of parenteral","text_display":" the administration of EBRT was not associated with enhanced toxicities with the exception of parenteral","confidence":1,"confidence_rate":1},{"cnt":[[245,1547],[1880,1547],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1546,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69c0d9061004438aaa730c36c0452aa9","type":"text","conversion_output":true,"text":"nutrition requirement, which occurred in \\(55 \\%\\) and \\(44 \\%\\) of patients who did and did not receive EBRT,","text_display":" nutrition requirement, which occurred in \\(55 \\%\\) and \\(44 \\%\\) of patients who did and did not receive EBRT,","confidence":0.99658203125,"confidence_rate":0.9999685892699369},{"cnt":[[245,1590],[1880,1590],[1880,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1589,"width":1636,"height":51},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ebb1daca52c49eebbda6ed9d595c108","type":"text","conversion_output":true,"text":"respectively \\(( P =0.049)\\). Furthermore, 36 Gy is well within normal tissue tolerance for most organs within","text_display":" respectively \\(( P =0.049)\\). Furthermore, 36 Gy is well within normal tissue tolerance for most organs within","confidence":0.9509219075553119,"confidence_rate":0.999577204227335},{"cnt":[[245,1635],[1880,1635],[1880,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1634,"width":1636,"height":49},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ad51ee7c2d54574891be9148aab4e87","type":"text","conversion_output":true,"text":"the field of radiation. Kidneys and liver will likely prove to be the dose-limiting structures and the same","text_display":" the field of radiation. Kidneys and liver will likely prove to be the dose-limiting structures and the same","confidence":1,"confidence_rate":1},{"cnt":[[245,1680],[1880,1680],[1880,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1680,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f69d91b95774ce2a4eceadb39a8001c","type":"text","conversion_output":true,"text":"guidelines for maximal doses to normal structures will be followed, as is standard in all current","text_display":" guidelines for maximal doses to normal structures will be followed, as is standard in all current","confidence":1,"confidence_rate":1},{"cnt":[[245,1723],[1880,1723],[1880,1768],[245,1768]],"region":{"top_left_x":244,"top_left_y":1723,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1bef1fbb37247f3b5c07f46245fc9c6","type":"text","conversion_output":true,"text":"neuroblastoma protocols. It should also be noted that the boost for patients with incomplete resections","text_display":" neuroblastoma protocols. 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However, the","text_display":" spinal cord compression is an oncologic emergency that warrants immediate intervention. However, the","confidence":1,"confidence_rate":1},{"cnt":[[245,1104],[1880,1104],[1880,1149],[245,1149]],"region":{"top_left_x":244,"top_left_y":1104,"width":1636,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a97fa0f75e64d4398237ac2a0857915","type":"text","conversion_output":true,"text":"choice of emergent therapy remains somewhat controversial, with pediatric oncologists favoring","text_display":" choice of emergent therapy remains somewhat controversial, with pediatric oncologists favoring","confidence":1,"confidence_rate":1},{"cnt":[[245,1145],[1880,1145],[1880,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1145,"width":1636,"height":52},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6af9d4874494aa19b181b43b20105cc","type":"text","conversion_output":true,"text":"chemotherapy and neurosurgeons favoring laminectomy with surgical decompression. \\({ }^{69}\\) There are several","text_display":" chemotherapy and neurosurgeons favoring laminectomy with surgical decompression. \\({ }^{69}\\) There are several","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1880,1195],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1194,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c5145f463264e5182ad11213fef96a7","type":"text","conversion_output":true,"text":"retrospective reports of similar neurologic outcome for patients treated with chemotherapy versus","text_display":" retrospective reports of similar neurologic outcome for patients treated with chemotherapy versus","confidence":1,"confidence_rate":1},{"cnt":[[245,1231],[1880,1231],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1231,"width":1636,"height":52},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"579b617c9fb6408e872149574379000a","type":"text","conversion_output":true,"text":"laminectomy, \\({ }^{70-73}\\) and therefore emergent chemotherapy has become a preferable alternative to","text_display":" laminectomy, \\({ }^{70-73}\\) and therefore emergent chemotherapy has become a preferable alternative to","confidence":1,"confidence_rate":1},{"cnt":[[245,1280],[1880,1280],[1880,1328],[245,1328]],"region":{"top_left_x":244,"top_left_y":1280,"width":1636,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e53fee1bcd7849e590ec129d3bbb9e32","type":"text","conversion_output":true,"text":"laminectomy in most cases, in an effort to diminish the devastating late orthopedic effects of laminectomy","text_display":" laminectomy in most cases, in an effort to diminish the devastating late orthopedic effects of laminectomy","confidence":1,"confidence_rate":1},{"cnt":[[245,1326],[1880,1326],[1880,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1325,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23fc454ea7d0403683f9641afa1d1696","type":"text","conversion_output":true,"text":"in infants or young children. Radiation therapy has generally been reserved for situations of progressive","text_display":" in infants or young children. Radiation therapy has generally been reserved for situations of progressive","confidence":1,"confidence_rate":1},{"cnt":[[245,1371],[1431,1371],[1431,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1370,"width":1187,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8a9320f6562498d888d2cff504a1882","type":"text","conversion_output":true,"text":"or persistent neurologic dysfunction despite chemotherapy and laminectomy.","text_display":" or persistent neurologic dysfunction despite chemotherapy and laminectomy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1457],[1880,1457],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1456,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc3e474870ab460eb201b43ba2c07ff7","type":"text","conversion_output":true,"text":"This study will prospectively characterize multiple aspects of neurologic disability at diagnosis and","text_display":"\n\nThis study will prospectively characterize multiple aspects of neurologic disability at diagnosis and","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1547],[245,1547]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"726a199a8f0e4bd1bc31af0b8a75dbe3","type":"text","conversion_output":true,"text":"during the follow-up period in an effort to systematically study the neurologic outcome of patients with","text_display":" during the follow-up period in an effort to systematically study the neurologic outcome of patients with","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1880,1543],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f7e1190d4b145ddb77bcc1ae35513cf","type":"text","conversion_output":true,"text":"primary neuroblastoma tumors with intraspinal extension (see Appendix III). A multidisciplinary","text_display":" primary neuroblastoma tumors with intraspinal extension (see Appendix III). A multidisciplinary","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[1880,1590],[1880,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1589,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1259a2ba5cc043499119e2abdbe56823","type":"text","conversion_output":true,"text":"evaluation at the time of diagnosis, including oncology, neurosurgery, and radiation oncology, is strongly","text_display":" evaluation at the time of diagnosis, including oncology, neurosurgery, and radiation oncology, is strongly","confidence":1,"confidence_rate":1},{"cnt":[[245,1633],[1880,1633],[1880,1678],[245,1678]],"region":{"top_left_x":244,"top_left_y":1632,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f5a0b0c05444740807301d1ef1539ff","type":"text","conversion_output":true,"text":"encouraged. It is the intent of this study that patients with clinical signs of spinal cord compression will","text_display":" encouraged. It is the intent of this study that patients with clinical signs of spinal cord compression will","confidence":1,"confidence_rate":1},{"cnt":[[245,1676],[1880,1676],[1880,1723],[245,1723]],"region":{"top_left_x":244,"top_left_y":1675,"width":1636,"height":49},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87a2955d0269479e8854708f64995508","type":"text","conversion_output":true,"text":"be treated with primary chemotherapy, unless the multidisciplinary evaluation determines that surgical","text_display":" be treated with primary chemotherapy, unless the multidisciplinary evaluation determines that surgical","confidence":1,"confidence_rate":1},{"cnt":[[245,1721],[1880,1721],[1880,1766],[245,1766]],"region":{"top_left_x":244,"top_left_y":1720,"width":1636,"height":47},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cbfcd63875e411a892e8f7093577427","type":"text","conversion_output":true,"text":"decompression would be more appropriate. Radiation therapy should be reserved for patients whose","text_display":" decompression would be more appropriate. Radiation therapy should be reserved for patients whose","confidence":1,"confidence_rate":1},{"cnt":[[245,1764],[1489,1764],[1489,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1763,"width":1245,"height":49},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c63a60f1afab4bbd91e693bffc794b8b","type":"text","conversion_output":true,"text":"neurologic status deteriorates despite chemotherapy and surgical decompression.","text_display":" neurologic status deteriorates despite chemotherapy and surgical decompression.","confidence":1,"confidence_rate":1},{"cnt":[[241,1848],[707,1848],[707,1904],[241,1904]],"region":{"top_left_x":240,"top_left_y":1847,"width":467,"height":57},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0da2f7c589f4d3cb11fbf3d3a8b49f8","type":"section_header","conversion_output":false,"children_ids":["e9a8008a9ab54a67a143f3ef906ccd55"],"text":"","text_display":""},{"cnt":[[245,1852],[703,1852],[703,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1851,"width":459,"height":47},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9a8008a9ab54a67a143f3ef906ccd55","type":"text","conversion_output":true,"parent_id":"c0da2f7c589f4d3cb11fbf3d3a8b49f8","text":"2.11 Maintenance Therapy","text_display":"\n\n\\subsection*{2.11 Maintenance Therapy}","confidence":1,"confidence_rate":1},{"cnt":[[245,1895],[1880,1895],[1880,1944],[245,1944]],"region":{"top_left_x":244,"top_left_y":1894,"width":1636,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfcd098e4a3446aab1d495c31a800e7d","type":"text","conversion_output":true,"text":"The presence of minimal residual disease despite achievement of maximal response to induction and","text_display":"\n\nThe presence of minimal residual disease despite achievement of maximal response to induction and","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1880,1938],[1880,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1937,"width":1636,"height":51},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"791dc0d314e244799f0247c34a202048","type":"text","conversion_output":true,"text":"consolidation therapy results in continued risk for neuroblastoma relapse. This was demonstrated in the","text_display":" consolidation therapy results in continued risk for neuroblastoma relapse. This was demonstrated in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1985],[1880,1985],[1880,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1985,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76e83afa19c644629bbd987673740409","type":"text","conversion_output":true,"text":"CCG-3891 study where the benefit of additional non-cross resistant therapy, 13-cis Retinoid acid (cis-","text_display":" CCG-3891 study where the benefit of additional non-cross resistant therapy, 13-cis Retinoid acid (cis","confidence":1,"confidence_rate":1},{"cnt":[[245,2028],[1880,2028],[1880,2073],[245,2073]],"region":{"top_left_x":244,"top_left_y":2028,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7dedda1d974e4ceca97252ecc222a2aa","type":"text","conversion_output":true,"text":"RA) administered following myeloablative consolidation therapy was observed. Patients with newly","text_display":"RA) administered following myeloablative consolidation therapy was observed. Patients with newly","confidence":1,"confidence_rate":1},{"cnt":[[245,2071],[1880,2071],[1880,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2071,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f6c3b1a992840a49b85dad59a59f61e","type":"text","conversion_output":true,"text":"diagnosed high-risk neuroblastoma enrolled in CCG3891 were randomized at week 34 of therapy","text_display":" diagnosed high-risk neuroblastoma enrolled in CCG3891 were randomized at week 34 of therapy","confidence":1,"confidence_rate":1},{"cnt":[[245,2114],[1880,2114],[1880,2161],[245,2161]],"region":{"top_left_x":244,"top_left_y":2114,"width":1636,"height":48},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e067332433643438282c56cdc96bdca","type":"text","conversion_output":true,"text":"(following either chemotherapy or ABMT consolidation) to no further therapy versus cis-RA for six","text_display":" (following either chemotherapy or ABMT consolidation) to no further therapy versus cis-RA for six","confidence":0.9990234375,"confidence_rate":0.9999904212258001},{"cnt":[[245,2159],[1880,2159],[1880,2206],[245,2206]],"region":{"top_left_x":244,"top_left_y":2159,"width":1636,"height":48},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02beb41dceca44d2b91bc7c29b847144","type":"text","conversion_output":true,"text":"months. Cis-RA or isotretinoin is a synthetic retinoid derived from the naturally occurring all transretinoic","text_display":" months. Cis-RA or isotretinoin is a synthetic retinoid derived from the naturally occurring all transretinoic","confidence":1,"confidence_rate":1},{"cnt":[[245,2204],[1880,2204],[1880,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2204,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"867239b0868648baafbb935406a3a95b","type":"text","conversion_output":true,"text":"acid by modification of the terminal carboxyl group. When neuroblastoma cell lines are exposed to all-","text_display":" acid by modification of the terminal carboxyl group. When neuroblastoma cell lines are exposed to all-","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,2247],[1880,2247],[1880,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2247,"width":1636,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b36d93be2834756a51c105e2d1bb473","type":"text","conversion_output":true,"text":"trans-retinoic acid (trans-RA) or cis-RA in vitro, they exhibit decreased proliferation, decreased","text_display":"trans-retinoic acid (trans-RA) or cis-RA in vitro, they exhibit decreased proliferation, decreased","confidence":1,"confidence_rate":1},{"cnt":[[245,2286],[1880,2286],[1880,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2285,"width":1636,"height":55},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7049f83c5478486a89133fc01242ee52","type":"text","conversion_output":true,"text":"expression of the MYCN oncogene, and morphological differentiation. \\({ }^{74-77}\\) Growth arrest and","text_display":" expression of the MYCN oncogene, and morphological differentiation. \\({ }^{74-77}\\) Growth arrest and","confidence":0.611328125,"confidence_rate":0.9953681054216599},{"cnt":[[245,2333],[1880,2333],[1880,2378],[245,2378]],"region":{"top_left_x":244,"top_left_y":2333,"width":1636,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7ffb5259bc941e381e4ae0f230967ca","type":"text","conversion_output":true,"text":"differentiation in response to cis-RA have been observed in neuroblastoma cell lines initiated from tumors","text_display":" differentiation in response to cis-RA have been observed in neuroblastoma cell lines initiated from tumors","confidence":1,"confidence_rate":1},{"cnt":[[245,2374],[1880,2374],[1880,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2374,"width":1636,"height":52},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf270d8033944ff7966ff4a59b785d71","type":"text","conversion_output":true,"text":"at the time of progression after chemoradiotherapy, \\({ }^{74,75}\\) suggesting that resistance to cytotoxic","text_display":" at the time of progression after chemoradiotherapy, \\({ }^{74,75}\\) suggesting that resistance to cytotoxic","confidence":1,"confidence_rate":1},{"cnt":[[245,2423],[1880,2423],[1880,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2423,"width":1636,"height":46},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56f6bafcb4d344ccb29782f925b5dc77","type":"text","conversion_output":true,"text":"chemotherapy does not induce resistance to cis-RA. cis-RA was well tolerated in a pediatric Phase I trial","text_display":" chemotherapy does not induce resistance to cis-RA. cis-RA was well tolerated in a pediatric Phase I trial","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,2466],[1880,2466],[1880,2512],[245,2512]],"region":{"top_left_x":244,"top_left_y":2466,"width":1636,"height":46},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4226f553eb804826b0b2fb09f13e3042","type":"text","conversion_output":true,"text":"using an intermittent administration schedule of twice daily administration for 14 days followed by 14","text_display":" using an intermittent administration schedule of twice daily administration for 14 days followed by 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0.027 in a test of proportions. \\({ }^{13}\\) This advantage for EFS was seen","text_display":" further therapy ( \\(29 \\%\\) ), with p value of 0.027 in a test of proportions. \\({ }^{13}\\) This advantage for EFS was seen","confidence":0.9980480668600649,"confidence_rate":0.9999854192059721},{"cnt":[[245,316],[1880,316],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":315,"width":1636,"height":49},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd83f30ad6664340bdac099dc71c424b","type":"text","conversion_output":true,"text":"in subgroups by prior randomization, such that the best overall EFS was for patients treated with ABMT","text_display":" in subgroups by prior randomization, such that the best overall EFS was for patients treated with ABMT","confidence":1,"confidence_rate":1},{"cnt":[[245,361],[1880,361],[1880,406],[245,406]],"region":{"top_left_x":244,"top_left_y":360,"width":1636,"height":47},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9094f43f658041bba5052f4ef01007df","type":"text","conversion_output":true,"text":"with cis-RA ( \\(55 \\%\\) EFS), second was ABMT without cis-RA ( \\(39 \\%\\) ), third was chemotherapy","text_display":" with cis-RA ( \\(55 \\%\\) EFS), second was ABMT without cis-RA ( \\(39 \\%\\) ), third was chemotherapy","confidence":0.9858922734856606,"confidence_rate":0.9998535345781576},{"cnt":[[245,404],[1588,404],[1588,449],[245,449]],"region":{"top_left_x":244,"top_left_y":403,"width":1344,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6c1a5fc88034dce86861de50dbccaa3","type":"text","conversion_output":true,"text":"consolidation with cis-RA ( \\(32 \\%\\) ), and fourth was chemotherapy without cis-RA ( \\(18 \\%\\) ).","text_display":" consolidation with cis-RA ( \\(32 \\%\\) ), and fourth was chemotherapy without cis-RA ( \\(18 \\%\\) ).","confidence":0.5349082874349663,"confidence_rate":0.9935706544547727},{"cnt":[[245,490],[1880,490],[1880,537],[245,537]],"region":{"top_left_x":244,"top_left_y":489,"width":1636,"height":49},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53daabe39ea84eefac09f2892ddb4ccc","type":"text","conversion_output":true,"text":"Despite the use of cis-RA, greater than \\(40 \\%\\) of children will develop recurrent neuroblastoma. To further","text_display":"\n\nDespite the use of cis-RA, greater than \\(40 \\%\\) of children will develop recurrent neuroblastoma. To further","confidence":0.99755859375,"confidence_rate":0.9999781753154674},{"cnt":[[245,535],[1880,535],[1880,580],[245,580]],"region":{"top_left_x":244,"top_left_y":534,"width":1636,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"358a60b46cd94db1b47d2f010d06d67e","type":"text","conversion_output":true,"text":"improve outcome, the efficacy of novel, anti-neuroblastoma targeted immunotherapy to eliminate","text_display":" improve outcome, the efficacy of novel, anti-neuroblastoma targeted immunotherapy to eliminate","confidence":1,"confidence_rate":1},{"cnt":[[245,578],[1880,578],[1880,625],[245,625]],"region":{"top_left_x":244,"top_left_y":577,"width":1636,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf1a42502a30479d9add71eb14cb0fd6","type":"text","conversion_output":true,"text":"minimal residual disease has been evaluated. Anti-gangliosidase (GD2) monoclonal antibody ch14.18 has","text_display":" minimal residual disease has been evaluated. Anti-gangliosidase (GD2) monoclonal antibody ch14.18 has","confidence":1,"confidence_rate":1},{"cnt":[[245,623],[1880,623],[1880,668],[245,668]],"region":{"top_left_x":244,"top_left_y":623,"width":1636,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e30ca44f8ab4408bf0b0084e556253b","type":"text","conversion_output":true,"text":"shown preclinical and early clinical activity against neuroblastoma, which was enhanced when combined","text_display":" shown preclinical and early clinical activity against neuroblastoma, which was enhanced when combined","confidence":1,"confidence_rate":1},{"cnt":[[245,666],[1880,666],[1880,711],[245,711]],"region":{"top_left_x":244,"top_left_y":666,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"191b9bac97e845b097c0c0e58771ef7e","type":"text","conversion_output":true,"text":"with GM-CSF or IL2. COG ANBL0032 was designed to determine if adding ch14.18 + GM-CSF + IL2","text_display":" with GM-CSF or IL2. COG ANBL0032 was designed to determine if adding ch14.18 + GM-CSF + IL2","confidence":0.99755859375,"confidence_rate":0.9999745379143542},{"cnt":[[245,709],[1880,709],[1880,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1636,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25b6066d836b48fe8975395fc1c00ad7","type":"text","conversion_output":true,"text":"to standard therapy of isotretinoin after intensive multimodality therapy improved outcome for high-risk","text_display":" to standard therapy of isotretinoin after intensive multimodality therapy improved outcome for high-risk","confidence":1,"confidence_rate":1},{"cnt":[[245,756],[1880,756],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":756,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b211acd67cae48b889e50cf1ff6517cb","type":"text","conversion_output":true,"text":"neuroblastoma patients. High-risk neuroblastoma patients who responded to induction therapy and stem","text_display":" neuroblastoma patients. High-risk neuroblastoma patients who responded to induction therapy and stem","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[1880,799],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fadbe44be0347b7be44f1f9149848d8","type":"text","conversion_output":true,"text":"cell transplant were randomized to 6 cycles of isotretinoin (standard therapy) or 6 cycles of isotretinoin","text_display":" cell transplant were randomized to 6 cycles of isotretinoin (standard therapy) or 6 cycles of isotretinoin","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[1880,842],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":842,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60d8f9dfe0944d6ba5c5c4fac84844f7","type":"text","conversion_output":true,"text":"with 5 concomitant cycles of ch14.18 combined with GM-CSF or IL2 in alternating cycles","text_display":" with 5 concomitant cycles of ch14.18 combined with GM-CSF or IL2 in alternating cycles","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1878,885],[1878,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1634,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3cfa6e1837749ac8328085b3f2c5cd0","type":"text","conversion_output":true,"text":"(immunotherapy). An intent-to-treat randomized comparison (Lan-DeMets interim monitoring,","text_display":" (immunotherapy). An intent-to-treat randomized comparison (Lan-DeMets interim monitoring,","confidence":1,"confidence_rate":1},{"cnt":[[245,928],[1880,928],[1880,975],[245,975]],"region":{"top_left_x":244,"top_left_y":928,"width":1636,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65523bfe6aed45199ffd9e76601e5090","type":"text","conversion_output":true,"text":"cumulative alpha \\(=0.025\\) ) was performed for event free survival (EFS). A total of 226 eligible patients","text_display":" cumulative alpha \\(=0.025\\) ) was performed for event free survival (EFS). A total of 226 eligible patients","confidence":0.99853515625,"confidence_rate":0.9999871411556362},{"cnt":[[245,973],[1876,973],[1876,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":973,"width":1632,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bcf690ae95c4ce79f476505a6e6720c","type":"text","conversion_output":true,"text":"were evenly randomized to standard or immunotherapy. Immunotherapy was associated with grade \\(\\geq 3\\)","text_display":" were evenly randomized to standard or immunotherapy. Immunotherapy was associated with grade \\(\\geq 3\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1018],[1878,1018],[1878,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1018,"width":1634,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09752f62546b4f2ebd08229a403e15a3","type":"text","conversion_output":true,"text":"pain, vascular leak syndrome and hypersensitivity reactions in \\(51 \\%, 23 \\%\\) and \\(25 \\%\\) of patients,","text_display":" pain, vascular leak syndrome and hypersensitivity reactions in \\(51 \\%, 23 \\%\\) and \\(25 \\%\\) of patients,","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1876,1061],[1876,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1061,"width":1632,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c10aa563aef44f6fa34d690f59318b4a","type":"text","conversion_output":true,"text":"respectively. With \\(61 \\%\\) of expected events observed, the study met criteria for early stopping for efficacy.","text_display":" respectively. With \\(61 \\%\\) of expected events observed, the study met criteria for early stopping for efficacy.","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,1104],[1878,1104],[1878,1152],[245,1152]],"region":{"top_left_x":244,"top_left_y":1104,"width":1634,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb4cdbbd3f0b44b684fb8dd4bf256292","type":"text","conversion_output":true,"text":"Median follow-up was 2.1 years. Two-year EFS estimates were \\(66 \\% \\pm 5 \\%\\) for patients randomized to","text_display":" Median follow-up was 2.1 years. Two-year EFS estimates were \\(66 \\% \\pm 5 \\%\\) for patients randomized to","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1880,1147],[1880,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1147,"width":1636,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0302d0482626433c8c2ffaba09521a7f","type":"text","conversion_output":true,"text":"immunotherapy versus \\(46 \\% \\pm 5 \\%\\) for standard therapy ( \\(p=0.01\\) ). OS was also superior ( \\(p=0.02\\), unadjusted","text_display":" immunotherapy versus \\(46 \\% \\pm 5 \\%\\) for standard therapy ( \\(p=0.01\\) ). OS was also superior ( \\(p=0.02\\), unadjusted","confidence":0.9714336274191737,"confidence_rate":0.9997523184371988},{"cnt":[[245,1195],[1880,1195],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1194,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6910ff27d814e81a5e6bf191a129d94","type":"text","conversion_output":true,"text":"for interim looks) for immunotherapy: \\(\\left(86 \\% \\pm 4 \\%^{*}\\right)\\) versus isotretinoin alone \\(\\left(75 \\% \\pm 5 \\%^{*}\\right)\\). Moreover, for","text_display":" for interim looks) for immunotherapy: \\(\\left(86 \\% \\pm 4 \\%^{*}\\right)\\) versus isotretinoin alone \\(\\left(75 \\% \\pm 5 \\%^{*}\\right)\\). Moreover, for","confidence":0.7744884832368182,"confidence_rate":0.9979412150403228},{"cnt":[[245,1238],[1880,1238],[1880,1285],[245,1285]],"region":{"top_left_x":244,"top_left_y":1237,"width":1636,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92d622a24a9847ac908625c39ed112b2","type":"text","conversion_output":true,"text":"the major subgroup of patients \\(\\geq 1\\) year of age with stage 4 disease, EFS was significantly greater ( \\(p =\\)","text_display":" the major subgroup of patients \\(\\geq 1\\) year of age with stage 4 disease, EFS was significantly greater ( \\(p =\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1283],[1880,1283],[1880,1330],[245,1330]],"region":{"top_left_x":244,"top_left_y":1282,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a94b7723bc214a10aafc9065368df081","type":"text","conversion_output":true,"text":"0.02 ) for the immunotherapy group ( \\(63 \\% \\pm 6 \\% *\\) ), as compared to isotretinoin alone ( \\(42 \\% \\pm 6 \\% *\\) ). (*2-year","text_display":" 0.02 ) for the immunotherapy group ( \\(63 \\% \\pm 6 \\% *\\) ), as compared to isotretinoin alone ( \\(42 \\% \\pm 6 \\% *\\) ). (*2-year","confidence":0.522609150146245,"confidence_rate":0.9942737901874317},{"cnt":[[245,1328],[1472,1328],[1472,1373],[245,1373]],"region":{"top_left_x":244,"top_left_y":1327,"width":1228,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7feb9b8ef4b84bb6a5690edff8ee9928","type":"text","conversion_output":true,"text":"estimates) (Alice Yu; personal communication, COG ANBL0032 study report).","text_display":" estimates) (Alice Yu; personal communication, COG ANBL0032 study report).","confidence":1,"confidence_rate":1},{"cnt":[[245,1414],[1880,1414],[1880,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":51},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"009bc2a8271346bf810d202649d0ab22","type":"text","conversion_output":true,"text":"Immunotherapy consisting of ch14.18 with GM-CSF and IL2 significantly improves outcome for high-","text_display":"\n\nImmunotherapy consisting of ch14.18 with GM-CSF and IL2 significantly improves outcome for high","confidence":1,"confidence_rate":1},{"cnt":[[245,1461],[1880,1461],[1880,1506],[245,1506]],"region":{"top_left_x":244,"top_left_y":1460,"width":1636,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e67af29b5a0941609fe7e336d96d7800","type":"text","conversion_output":true,"text":"risk neuroblastoma patients. Ch14.18 remains under clinical investigation through COG ANBL0032 and","text_display":"risk neuroblastoma patients. Ch14.18 remains under clinical investigation through COG ANBL0032 and","confidence":1,"confidence_rate":1},{"cnt":[[245,1504],[1880,1504],[1880,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1503,"width":1636,"height":47},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"435f0279a7134b8da75435d24a81e01f","type":"text","conversion_output":true,"text":"ANBL0931 protocols to further evaluate efficacy and toxicity. Given the significant improvement in","text_display":" ANBL0931 protocols to further evaluate efficacy and toxicity. Given the significant improvement in","confidence":1,"confidence_rate":1},{"cnt":[[245,1547],[1880,1547],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1546,"width":1636,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50ee0c95575b44e693f22bcbb91a458e","type":"text","conversion_output":true,"text":"survival from high risk neuroblastoma following antiGD2 antibody therapy, patients enrolled onto","text_display":" survival from high risk neuroblastoma following antiGD2 antibody therapy, patients enrolled onto","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[1878,1590],[1878,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1589,"width":1634,"height":51},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d225f999b84b4c01b56b6ef296009a37","type":"text","conversion_output":true,"text":"ANBL0532 should be encouraged to participate in actively enrolling clinical trials of ch14.18 antibody,","text_display":" ANBL0532 should be encouraged to participate in actively enrolling clinical trials of ch14.18 antibody,","confidence":1,"confidence_rate":1},{"cnt":[[245,1637],[1880,1637],[1880,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1637,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ca4d8b30aba4f969228fffceab9b2ca","type":"text","conversion_output":true,"text":"(i.e. ANBL0032 or ANBL0931). Patients who are not eligible to receive ch14.18 antibody therapy or","text_display":" (i.e. ANBL0032 or ANBL0931). Patients who are not eligible to receive ch14.18 antibody therapy or","confidence":1,"confidence_rate":1},{"cnt":[[245,1680],[1880,1680],[1880,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1680,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56b49c5287cc4a869eff22fc27d3502a","type":"text","conversion_output":true,"text":"decline immunotherapy will remain on ANBL0532 and receive six months of cis-RA post ASCT based","text_display":" decline immunotherapy will remain on ANBL0532 and receive six months of cis-RA post ASCT based","confidence":1,"confidence_rate":1},{"cnt":[[245,1723],[1532,1723],[1532,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1723,"width":1288,"height":50},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ada9f2b1e1a4549b9eb51cd22f21a7c","type":"text","conversion_output":true,"text":"on the significant improvement in EFS with cis-RA documented by CCG3891 trial.","text_display":" on the significant improvement in EFS with cis-RA documented by CCG3891 trial.","confidence":0.9990234375,"confidence_rate":0.9999882285072625},{"cnt":[[236,1805],[840,1805],[840,1863],[236,1863]],"region":{"top_left_x":236,"top_left_y":1804,"width":605,"height":59},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbb91b3fff1b47cca4e8359691ec7d07","type":"section_header","conversion_output":false,"children_ids":["7f1e79c52c2c4c43bae92b19a76c4796"],"text":"","text_display":""},{"cnt":[[245,1809],[836,1809],[836,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1808,"width":592,"height":51},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f1e79c52c2c4c43bae92b19a76c4796","type":"text","conversion_output":true,"parent_id":"bbb91b3fff1b47cca4e8359691ec7d07","text":"2.12 Biologic Correlative Studies","text_display":"\n\n\\subsection*{2.12 Biologic Correlative Studies}","confidence":1,"confidence_rate":1},{"cnt":[[241,1895],[887,1895],[887,1944],[241,1944]],"region":{"top_left_x":240,"top_left_y":1894,"width":648,"height":51},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9622fbe7887c462a84110f4717004ea8","type":"section_header","conversion_output":false,"children_ids":["af8879da51dc4044bdae0af3d4eed40d"],"text":"","text_display":""},{"cnt":[[245,1899],[883,1899],[883,1940],[245,1940]],"region":{"top_left_x":244,"top_left_y":1899,"width":640,"height":42},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af8879da51dc4044bdae0af3d4eed40d","type":"text","conversion_output":true,"parent_id":"9622fbe7887c462a84110f4717004ea8","text":"2.12.1 Enrollment on COG ANBL00B1","text_display":"\n\n\\subsection*{2.12.1 Enrollment on COG ANBL00B1}","confidence":1,"confidence_rate":1},{"cnt":[[245,1942],[1880,1942],[1880,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1942,"width":1636,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7b785a055f2431582ea235895c23196","type":"text","conversion_output":true,"text":"Enrollment on COG ANBL00B1 (Neuroblastoma Biology Study) is an eligibility requirement for","text_display":"\n\nEnrollment on COG ANBL00B1 (Neuroblastoma Biology Study) is an eligibility requirement for","confidence":1,"confidence_rate":1},{"cnt":[[245,1985],[1880,1985],[1880,2032],[245,2032]],"region":{"top_left_x":244,"top_left_y":1985,"width":1636,"height":48},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f47cdf97df6f4d208bf818df2fc9472b","type":"text","conversion_output":true,"text":"ANBL0532 as assignment to clinical risks groups and different COG neuroblastoma therapeutic clinical","text_display":" ANBL0532 as assignment to clinical risks groups and different COG neuroblastoma therapeutic clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,2030],[1880,2030],[1880,2075],[245,2075]],"region":{"top_left_x":244,"top_left_y":2030,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01e899020f1048dd9b2443ace16ec029","type":"text","conversion_output":true,"text":"trials is dependent upon accurate histologic and biologic diagnosis. 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Although submission of paraffin","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1880,2075],[1880,2121],[245,2121]],"region":{"top_left_x":244,"top_left_y":2075,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32ae172d3e7841cfb85260c9794a7535","type":"text","conversion_output":true,"text":"embedded tissue is acceptable for enrollment onto ANBL00B1, the COG Neuroblastoma committee","text_display":"embedded tissue is acceptable for enrollment onto ANBL00B1, the COG Neuroblastoma committee","confidence":1,"confidence_rate":1},{"cnt":[[245,2118],[1876,2118],[1876,2163],[245,2163]],"region":{"top_left_x":244,"top_left_y":2118,"width":1632,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a851eb9679a41e3817bb8716aec69ff","type":"text","conversion_output":true,"text":"encourages the submission of fresh or snap-frozen tissue, peripheral blood, or bone marrow 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Auto-induction of","confidence":0.9965848922729492,"confidence_rate":0.9999667874203043},{"cnt":[[245,1586],[1880,1586],[1880,1631],[245,1631]],"region":{"top_left_x":244,"top_left_y":1585,"width":1636,"height":46},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6030af95198b4284a7de491220559478","type":"text","conversion_output":true,"text":"cyclophosphamide clearance was observed in 14 of the 15 children for whom cyclophosphamide AUC","text_display":" cyclophosphamide clearance was observed in 14 of the 15 children for whom cyclophosphamide AUC","confidence":1,"confidence_rate":1},{"cnt":[[245,1624],[1880,1624],[1880,1674],[245,1674]],"region":{"top_left_x":244,"top_left_y":1624,"width":1636,"height":50},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bf35bc34c9648a7820a272b3d3d55bd","type":"text","conversion_output":true,"text":"was available after doses 1 and 4, again similar to other reports. \\({ }^{86-89}\\) The \\(AUC _{\\text {HCY }}\\) and \\(AUC _{\\text {CEPM }}\\) increased","text_display":" was available after doses 1 and 4, again similar to other reports. \\({ }^{86-89}\\) The \\(AUC _{\\text {HCY }}\\) and \\(AUC _{\\text {CEPM }}\\) increased","confidence":0.3509110285533413,"confidence_rate":0.9934353367134281},{"cnt":[[245,1671],[853,1671],[853,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1671,"width":609,"height":50},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e4ab57adc4940d6893635cadafbbbfa","type":"text","conversion_output":true,"text":"in four and three children, respectively.","text_display":" in four and three children, respectively.","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[1878,1753],[1878,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1753,"width":1634,"height":46},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a75d97ed61244c72a4194c55030866a4","type":"text","conversion_output":true,"text":"Multivariate analysis was conducted to evaluate for determinants of AUC of cyclophosphamide, HCY","text_display":"\n\nMultivariate analysis was conducted to evaluate for determinants of AUC of cyclophosphamide, HCY","confidence":1,"confidence_rate":1},{"cnt":[[245,1796],[1880,1796],[1880,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1796,"width":1636,"height":46},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"966d60d07356413399f7a4236ecf912a","type":"text","conversion_output":true,"text":"and CEPM. Two of the 21 children received cyclophosphamide \\(13.3 mg / kg\\); their AUCs were","text_display":" and CEPM. Two of the 21 children received cyclophosphamide \\(13.3 mg / kg\\); their AUCs were","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1878,1835],[1878,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1634,"height":51},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9a99a975c9744fbb6948f58a96b0027","type":"text","conversion_output":true,"text":"normalized to cyclophosphamide \\(400 mg / m ^{2}\\) to allow for inclusion in this multivariate analysis.","text_display":" normalized to cyclophosphamide \\(400 mg / m ^{2}\\) to allow for inclusion in this multivariate analysis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1882,1882],[1882,1929],[245,1929]],"region":{"top_left_x":244,"top_left_y":1882,"width":1639,"height":48},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e17d2f5d9e2748cb903d711e734b4525","type":"text","conversion_output":true,"text":"Multivariate regression analysis indicated that age, weight and body surface area explained only \\(23 \\%\\) of","text_display":" Multivariate regression analysis indicated that age, weight and body surface area explained only \\(23 \\%\\) of","confidence":1,"confidence_rate":1},{"cnt":[[245,1927],[1880,1927],[1880,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1927,"width":1636,"height":48},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fae056b116cb4747842dbeee3d55845e","type":"text","conversion_output":true,"text":"the variability in CY clearance after dose 1. Furthermore, the AUC of cyclophosphamide and its","text_display":" the variability in CY clearance after dose 1. Furthermore, the AUC of cyclophosphamide and its","confidence":0.9951171875,"confidence_rate":0.9999505590770232},{"cnt":[[245,1972],[935,1972],[935,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1972,"width":691,"height":46},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac765bedbf184f2ca52b7224646ebee1","type":"text","conversion_output":true,"text":"metabolites were not consistently correlated.","text_display":" metabolites were not consistently correlated.","confidence":1,"confidence_rate":1},{"cnt":[[245,2052],[1880,2052],[1880,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2051,"width":1636,"height":49},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3cc1f5b56bc74c4cafd6f9e2abcc6f2d","type":"text","conversion_output":true,"text":"Cyclophosphamide pharmacokinetic assessments are unlikely to be used clinically given the variability in","text_display":"\n\nCyclophosphamide pharmacokinetic assessments are unlikely to be used clinically given the variability in","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1880,2097],[1880,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1636,"height":46},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"924dd513a96e4a74b13d9f8afa8bb159","type":"text","conversion_output":true,"text":"cyclophosphamide metabolism and the resource intensity of cyclophosphamide pharmacokinetic","text_display":" cyclophosphamide metabolism and the resource intensity of cyclophosphamide pharmacokinetic","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1880,2140],[1880,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2139,"width":1636,"height":46},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e379862068024e888d1334f1fdc5e299","type":"text","conversion_output":true,"text":"evaluations. Alternatively, genetic polymorphisms in genes involved in cyclophosphamide metabolism","text_display":" evaluations. Alternatively, genetic polymorphisms in genes involved in cyclophosphamide metabolism","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1880,2183],[1880,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2182,"width":1636,"height":49},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"092688ad45de4888b4b4542e76b502d8","type":"text","conversion_output":true,"text":"may correlate with cyclophosphamide pharmacokinetics and may predict toxicity and anti-tumor activity","text_display":" may correlate with cyclophosphamide pharmacokinetics and may predict toxicity and anti-tumor activity","confidence":1,"confidence_rate":1},{"cnt":[[245,2226],[1880,2226],[1880,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2225,"width":1636,"height":51},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3127f0a2caaa4eb0a2ba2b84d7b40ab1","type":"text","conversion_output":true,"text":"of the ANBL0532 cyclophosphamide containing induction regimen. Cyclophosphamide is activated by","text_display":" of the ANBL0532 cyclophosphamide containing induction regimen. Cyclophosphamide is activated by","confidence":1,"confidence_rate":1},{"cnt":[[245,2272],[1880,2270],[1880,2316],[245,2318]],"region":{"top_left_x":244,"top_left_y":2270,"width":1636,"height":49},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bca9e060dcfe4efb858e295bb6d052f3","type":"text","conversion_output":true,"text":"several cytochrome P450 enzymes which have genetic polymorphisms, specifically CYP3A4/5,","text_display":" several cytochrome P450 enzymes which have genetic polymorphisms, specifically CYP3A4/5,","confidence":1,"confidence_rate":1},{"cnt":[[245,2312],[1880,2312],[1880,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2311,"width":1636,"height":51},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"accd2b93fe434934b04f89feb9cdd799","type":"text","conversion_output":true,"text":"CYP2C19, CYP2C9 and CYP2B6. \\({ }^{90}\\) CYP2B6 \\({ }^{*} 5\\) and \\({ }^{*} 6\\) alleles have been associated with either altered","text_display":" CYP2C19, CYP2C9 and CYP2B6. \\({ }^{90}\\) CYP2B6 \\({ }^{*} 5\\) and \\({ }^{*} 6\\) alleles have been associated with either altered","confidence":0.5316644872464211,"confidence_rate":0.9951891464153791},{"cnt":[[245,2359],[1880,2359],[1880,2404],[245,2404]],"region":{"top_left_x":244,"top_left_y":2358,"width":1636,"height":47},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fd0207242be481881351f52d3b6a216","type":"text","conversion_output":true,"text":"activation of HCY or clinical outcome. Their frequencies in Caucasians are \\(25 \\%\\) and \\(26-41 \\%\\),","text_display":" activation of HCY or clinical outcome. Their frequencies in Caucasians are \\(25 \\%\\) and \\(26-41 \\%\\),","confidence":0.9786213990300894,"confidence_rate":0.999788155448279},{"cnt":[[245,2398],[1878,2398],[1878,2447],[245,2447]],"region":{"top_left_x":244,"top_left_y":2397,"width":1634,"height":51},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbbac1e5a90a4c509abca6fbe547cd13","type":"text","conversion_output":true,"text":"respectively. \\({ }^{91}\\) Several genetic polymorphisms in CYP2C9 have functional consequences on the enzyme's","text_display":" respectively. \\({ }^{91}\\) Several genetic polymorphisms in CYP2C9 have functional consequences on the enzyme's","confidence":1,"confidence_rate":1},{"cnt":[[245,2441],[1880,2441],[1880,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2440,"width":1636,"height":55},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af223c61422043afb2cf21a922fcd78c","type":"text","conversion_output":true,"text":"activity; CYP2C9*2 and CYP2C9*3 are the most common variants. \\({ }^{92}\\) In Caucasians, \\(65 \\%\\) of individuals","text_display":" activity; CYP2C9*2 and CYP2C9*3 are the most common variants. \\({ }^{92}\\) In Caucasians, \\(65 \\%\\) of individuals","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[245,2488],[1880,2488],[1880,2537],[245,2537]],"region":{"top_left_x":244,"top_left_y":2487,"width":1636,"height":51},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1fc42114ff54c4f9e342d511158153f","type":"text","conversion_output":true,"text":"are homozygotes for CYP2C9*1, 22\\% are heterozygous or homozygous for CYP2C9*2 and 13\\% carry","text_display":" are homozygotes for CYP2C9*1, 22\\% are heterozygous or homozygous for CYP2C9*2 and 13\\% carry","confidence":0.5147517379373312,"confidence_rate":0.9931064685177688},{"cnt":[[245,2535],[1880,2535],[1880,2580],[245,2580]],"region":{"top_left_x":244,"top_left_y":2535,"width":1636,"height":46},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0d62a7ce78f4eb38105cf6ceb03546b","type":"text","conversion_output":true,"text":"CYP2C9*3. The expression of these alleles is less common in African-Americans or Chinese (<2\\% -","text_display":" CYP2C9*3. The expression of these alleles is less common in African-Americans or Chinese (<2\\% -","confidence":0.9626633367445303,"confidence_rate":0.9996195571197135},{"cnt":[[1749,2608],[1876,2608],[1876,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":128,"height":46},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7154a749d133497991d726538a70e9d7","type":"page_info","conversion_output":false,"text":"Page 26","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-027","page":27,"lines":[{"cnt":[[245,99],[614,99],[614,165],[245,165]],"region":{"top_left_x":244,"top_left_y":98,"width":371,"height":68},"line":1,"column":0,"font_size":70,"is_printed":true,"is_handwritten":false,"id":"5ae17e65bf5d468aaa5b66235ea500c0","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[653,103],[1652,103],[1652,140],[653,140]],"region":{"top_left_x":653,"top_left_y":103,"width":1000,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6f311bff0ae440a9afacec5c56496cb2","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.6495842508738455,"confidence_rate":0.9946217307722369},{"cnt":[[1706,99],[1880,99],[1880,140],[1706,140]],"region":{"top_left_x":1705,"top_left_y":98,"width":175,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f8b88b9ae4b414b91094246b795c184","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,172],[655,172],[655,208],[331,208]],"region":{"top_left_x":330,"top_left_y":171,"width":326,"height":38},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d5fe3a5918b54ef098f0f7959687ea76","type":"text","conversion_output":true,"text":"Children's Oncology Group","text_display":"\n\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[245,217],[1884,217],[1884,273],[245,273]],"region":{"top_left_x":244,"top_left_y":216,"width":1641,"height":57},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f82d75aa4f1d4880acb58539b13c2117","type":"text","conversion_output":true,"text":"\\(3.5 \\%\\), respectively). \\({ }^{92,93}\\) The CYP2C9*2 allele is characterized by an arginine to cysteine exchange at","text_display":"\n\\(3.5 \\%\\), respectively). \\({ }^{92,93}\\) The CYP2C9*2 allele is characterized by an arginine to cysteine exchange at","confidence":0.9970703125,"confidence_rate":0.9999749234987387},{"cnt":[[243,271],[1884,271],[1884,318],[243,318]],"region":{"top_left_x":242,"top_left_y":270,"width":1643,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0f88532bc1e44beab9fcf9f920f5860","type":"text","conversion_output":true,"text":"position 144 (Cys144 - Ile 359), while in CYP2C9*3 isoleucine 359 is changed to leucine (Arg144 -","text_display":" position 144 (Cys144 - Ile 359), while in CYP2C9*3 isoleucine 359 is changed to leucine (Arg144 ","confidence":0.9951193332672119,"confidence_rate":0.9999546990253512},{"cnt":[[245,314],[1882,314],[1882,363],[245,363]],"region":{"top_left_x":244,"top_left_y":313,"width":1639,"height":51},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e7bf06d403c492bae043f7523f7f96f","type":"text","conversion_output":true,"text":"Leu359). Both CYP2C9*2 and CYP2C9*3 are non-null alleles which code for functional protein with","text_display":"Leu359). Both CYP2C9*2 and CYP2C9*3 are non-null alleles which code for functional protein with","confidence":1,"confidence_rate":1},{"cnt":[[245,357],[1882,357],[1882,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":1639,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97d4669aa65b4d3991cfc081e4e52f19","type":"text","conversion_output":true,"text":"reduced levels of enzyme activity. CYP2C9*2 carriers have a moderate reduction in activity, while the","text_display":" reduced levels of enzyme activity. CYP2C9*2 carriers have a moderate reduction in activity, while the","confidence":0.9844017028808594,"confidence_rate":0.9998516975016769},{"cnt":[[245,397],[1880,397],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":397,"width":1636,"height":53},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13af95c0f28b4af2807739f30e918797","type":"text","conversion_output":true,"text":"reduction in activity is most marked for CYP2C9*3. \\({ }^{92,93}\\) GSTA1, the predominant GST involved in the","text_display":" reduction in activity is most marked for CYP2C9*3. \\({ }^{92,93}\\) GSTA1, the predominant GST involved in the","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,447],[1880,447],[1880,492],[245,492]],"region":{"top_left_x":244,"top_left_y":446,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f8fde52a0d2459caa86e544ce5f1611","type":"text","conversion_output":true,"text":"metabolism of cyclophosphamide, exhibits a polymorphism that influences its hepatic expression.","text_display":" metabolism of cyclophosphamide, exhibits a polymorphism that influences its hepatic expression.","confidence":1,"confidence_rate":1},{"cnt":[[245,490],[1884,490],[1884,537],[245,537]],"region":{"top_left_x":244,"top_left_y":489,"width":1641,"height":49},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9ee9846af71471d80cd5c97174d1b54","type":"text","conversion_output":true,"text":"GSTA1*B, which is several linked single nucleotide polymorphisms in the proximal promoter region of","text_display":" GSTA1*B, which is several linked single nucleotide polymorphisms in the proximal promoter region of","confidence":1,"confidence_rate":1},{"cnt":[[245,533],[1880,533],[1880,580],[245,580]],"region":{"top_left_x":244,"top_left_y":532,"width":1636,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bb704758fc041889eb34dcad054ada1","type":"text","conversion_output":true,"text":"the GSTA1 gene, has reduced levels of GSTA1 enzyme. The expression of GSTA1*B does not differ by","text_display":" the GSTA1 gene, has reduced levels of GSTA1 enzyme. The expression of GSTA1*B does not differ by","confidence":1,"confidence_rate":1},{"cnt":[[245,578],[1882,578],[1882,625],[245,625]],"region":{"top_left_x":244,"top_left_y":577,"width":1639,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bef5d5ceac234ddc8451ec1d341421ee","type":"text","conversion_output":true,"text":"ethnic group; GSTA1*A/*B occurs in \\(49 \\%\\) and GSTA1*B/*B occurs in \\(16 \\%\\) of a population of breast","text_display":" ethnic group; GSTA1*A/*B occurs in \\(49 \\%\\) and GSTA1*B/*B occurs in \\(16 \\%\\) of a population of breast","confidence":0.9873511351179332,"confidence_rate":0.9998776080403308},{"cnt":[[245,614],[518,614],[518,668],[245,668]],"region":{"top_left_x":244,"top_left_y":614,"width":274,"height":55},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ab89405e503432e9cd5c0d08c471afe","type":"text","conversion_output":true,"text":"cancer patients. \\({ }^{94}\\)","text_display":" cancer patients. \\({ }^{94}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1880,700],[1880,750],[245,750]],"region":{"top_left_x":244,"top_left_y":700,"width":1636,"height":50},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd72925f194944e688c3fc6b88b58b66","type":"text","conversion_output":true,"text":"ANBL0532 will assess whether host genetic polymorphisms in CYP2B6, CYP2C9 and GSTA1","text_display":"\n\nANBL0532 will assess whether host genetic polymorphisms in CYP2B6, CYP2C9 and GSTA1","confidence":1,"confidence_rate":1},{"cnt":[[245,746],[1880,746],[1880,793],[245,793]],"region":{"top_left_x":244,"top_left_y":745,"width":1636,"height":48},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88e5a38f49e8427ca570a8d812f8cf44","type":"text","conversion_output":true,"text":"genotypes involved in the metabolic activation and clearance of cyclophosphamide are correlated with","text_display":" genotypes involved in the metabolic activation and clearance of cyclophosphamide are correlated with","confidence":1,"confidence_rate":1},{"cnt":[[245,791],[1880,791],[1880,836],[245,836]],"region":{"top_left_x":244,"top_left_y":790,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"069aa41949cd40b0acc930b5858e9f9b","type":"text","conversion_output":true,"text":"Cyclophosphamide/Topo associated toxicity and tumor response. Prior studies have established","text_display":" Cyclophosphamide/Topo associated toxicity and tumor response. Prior studies have established","confidence":1,"confidence_rate":1},{"cnt":[[245,834],[1880,834],[1880,881],[245,881]],"region":{"top_left_x":244,"top_left_y":833,"width":1636,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e863f16370c542a299a0c8ae6f02bc21","type":"text","conversion_output":true,"text":"genotype-phenotype relationships for the CYP2B6, CYP2C9 and GSTA1 genes for both in vitro","text_display":" genotype-phenotype relationships for the CYP2B6, CYP2C9 and GSTA1 genes for both in vitro","confidence":1,"confidence_rate":1},{"cnt":[[245,872],[1880,872],[1880,924],[245,924]],"region":{"top_left_x":244,"top_left_y":872,"width":1636,"height":52},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd7d4674370d47b6978acb651270180c","type":"text","conversion_output":true,"text":"analyses \\({ }^{95}\\) and in metastatic breast cancer patients receiving high dose cyclophosphamide as a component","text_display":" analyses \\({ }^{95}\\) and in metastatic breast cancer patients receiving high dose cyclophosphamide as a component","confidence":0.99951171875,"confidence_rate":0.9999958958025558},{"cnt":[[245,917],[1880,917],[1880,969],[245,969]],"region":{"top_left_x":244,"top_left_y":917,"width":1636,"height":52},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee09ea3e8d3f4596ac92000c5b8cd26e","type":"text","conversion_output":true,"text":"of a HSCT preparative regimen. \\({ }^{96}\\) The pharmacology laboratory at the Fred Hutchinson Cancer Research","text_display":" of a HSCT preparative regimen. \\({ }^{96}\\) The pharmacology laboratory at the Fred Hutchinson Cancer Research","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,967],[1880,967],[1880,1012],[245,1012]],"region":{"top_left_x":244,"top_left_y":966,"width":1636,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68b958edcb724eb1ab10a598b02cb66d","type":"text","conversion_output":true,"text":"Center is currently conducting an analysis of CYP2B6, CYP2C9, CYP3A5, ABCC2, GSTA1, GSTM1,","text_display":" Center is currently conducting an analysis of CYP2B6, CYP2C9, CYP3A5, ABCC2, GSTA1, GSTM1,","confidence":1,"confidence_rate":1},{"cnt":[[245,1010],[1880,1010],[1880,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1009,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81be3747aabd4e8b8008bfde01943f81","type":"text","conversion_output":true,"text":"GSTT1 genetic polymorphisms in 147 patients who received CY in combination with TBI in preparation","text_display":" GSTT1 genetic polymorphisms in 147 patients who received CY in combination with TBI in preparation","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1880,1053],[1880,1100],[245,1100]],"region":{"top_left_x":244,"top_left_y":1052,"width":1636,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"836ffe5fe8784d10a216cbbe75ad1006","type":"text","conversion_output":true,"text":"for HSCT. Preliminary analysis suggests that polymorphisms in CYP2B6, CYP2C9, and GSTA1 are key","text_display":" for HSCT. Preliminary analysis suggests that polymorphisms in CYP2B6, CYP2C9, and GSTA1 are key","confidence":1,"confidence_rate":1},{"cnt":[[245,1096],[1880,1096],[1880,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1095,"width":1636,"height":51},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34441a28385f43ef854e8cf9fd383e3b","type":"text","conversion_output":true,"text":"enzymes associated with toxicity (personal communication, J. McCune). An exploratory analysis of co-","text_display":" enzymes associated with toxicity (personal communication, J. McCune). An exploratory analysis of co","confidence":1,"confidence_rate":1},{"cnt":[[245,1141],[1880,1141],[1880,1188],[245,1188]],"region":{"top_left_x":244,"top_left_y":1140,"width":1636,"height":49},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe9def74301b402993b96d48ab4fa37a","type":"text","conversion_output":true,"text":"variance (ANCOVA) was conducted using limited ANBL02P1 data. Age was used as a co-variate for","text_display":"variance (ANCOVA) was conducted using limited ANBL02P1 data. Age was used as a co-variate for","confidence":1,"confidence_rate":1},{"cnt":[[245,1186],[1880,1186],[1880,1231],[245,1231]],"region":{"top_left_x":244,"top_left_y":1185,"width":1636,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ca2d0874fb4449dac7d7dba3729c0ae","type":"text","conversion_output":true,"text":"three genes (GST, CYP2C9, CYP2C19) upon the following endpoints after the first cyclophosphamide","text_display":" three genes (GST, CYP2C9, CYP2C19) upon the following endpoints after the first cyclophosphamide","confidence":1,"confidence_rate":1},{"cnt":[[245,1229],[1880,1229],[1880,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1228,"width":1636,"height":47},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0b60f8b4dd545ab8c35e56366ed0f5d","type":"text","conversion_output":true,"text":"dose (i.e., dose 1): AUCCY, CY clearance, AUCHCY, AUCCEPM. CYP2C9 was the only gene that","text_display":" dose (i.e., dose 1): AUCCY, CY clearance, AUCHCY, AUCCEPM. CYP2C9 was the only gene that","confidence":1,"confidence_rate":1},{"cnt":[[245,1272],[1880,1272],[1880,1319],[245,1319]],"region":{"top_left_x":244,"top_left_y":1271,"width":1636,"height":49},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd7a8e12f8364e8986caa6d7456a33d9","type":"text","conversion_output":true,"text":"trended towards statistical significance with AUCCY, cyclophosphamide clearance ( \\(p =0.37\\) ), AUCHCY","text_display":" trended towards statistical significance with AUCCY, cyclophosphamide clearance ( \\(p =0.37\\) ), AUCHCY","confidence":0.7315444946289062,"confidence_rate":0.9971362438647233},{"cnt":[[245,1317],[741,1317],[741,1364],[245,1364]],"region":{"top_left_x":244,"top_left_y":1316,"width":498,"height":49},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95707cb6086e4c59ba064ba32cd5c33d","type":"text","conversion_output":true,"text":"\\(( p =0.89)\\), AUCCEPM ( \\(p =0.80\\) ).","text_display":" \\(( p =0.89)\\), AUCCEPM ( \\(p =0.80\\) ).","confidence":0.9300962048582733,"confidence_rate":0.9983161343626565},{"cnt":[[241,1392],[973,1392],[973,1446],[241,1446]],"region":{"top_left_x":240,"top_left_y":1392,"width":734,"height":54},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93754de5088143eeb2f39e1d45fc2b45","type":"section_header","conversion_output":false,"children_ids":["d7250899fb7047a49d18cc984811ac87"],"text":"","text_display":""},{"cnt":[[245,1396],[967,1396],[967,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1396,"width":723,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7250899fb7047a49d18cc984811ac87","type":"text","conversion_output":true,"parent_id":"93754de5088143eeb2f39e1d45fc2b45","text":"2.12.3 13-cis Retinoic acid Pharmacokinetics","text_display":"\n\n\\subsection*{2.12.3 13-cis Retinoic acid Pharmacokinetics}","confidence":0.9990234375,"confidence_rate":0.9999800606141427},{"cnt":[[245,1439],[1880,1439],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a1a48c745d142e59d00fc09bd506606","type":"text","conversion_output":true,"text":"The variability of cis-RA continuous steady state (CSS) plasma levels and/or genetic variations in retinoic","text_display":"\n\nThe variability of cis-RA continuous steady state (CSS) plasma levels and/or genetic variations in retinoic","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[245,1482],[1880,1482],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1482,"width":1636,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"842b7e2dcb5348778776971502ac4998","type":"text","conversion_output":true,"text":"acid metabolic enzymes may correlate with event-free survival or systemic toxicity (CTC Grade \\(3 / 4\\) skin,","text_display":" acid metabolic enzymes may correlate with event-free survival or systemic toxicity (CTC Grade \\(3 / 4\\) skin,","confidence":0.989769458770752,"confidence_rate":0.9999073625532714},{"cnt":[[245,1525],[1880,1525],[1880,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1525,"width":1636,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c0d64444def44a08f4c5a57bd5ea8cd","type":"text","conversion_output":true,"text":"hypercalcemia and hepatic toxicity) in high-risk neuroblastoma patients. Pharmacokinetics studies","text_display":" hypercalcemia and hepatic toxicity) in high-risk neuroblastoma patients. Pharmacokinetics studies","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1880,1573],[1880,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1572,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a12bf80a4d14763b853f22fc1f5b73f","type":"text","conversion_output":true,"text":"performed on patients in the Phase I trial of cis-RA showed significant interpatient and intrapatient","text_display":" performed on patients in the Phase I trial of cis-RA showed significant interpatient and intrapatient","confidence":1,"confidence_rate":1},{"cnt":[[245,1616],[1880,1616],[1880,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1615,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e45437ec009c42daab7cda77973a8773","type":"text","conversion_output":true,"text":"variability in peak serum levels (mean peak serum cis-RA concentration: \\(7.2 \\pm 5.3 \\mu M\\); trough","text_display":" variability in peak serum levels (mean peak serum cis-RA concentration: \\(7.2 \\pm 5.3 \\mu M\\); trough","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1880,1659],[1880,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f817fd54b8d84994b1a6a79ef30423f0","type":"text","conversion_output":true,"text":"concentration: \\(4.1 \\pm 2.7 \\mu M\\) ). It was noted that peak serum concentrations above \\(10 \\mu M\\) were associated","text_display":" concentration: \\(4.1 \\pm 2.7 \\mu M\\) ). It was noted that peak serum concentrations above \\(10 \\mu M\\) were associated","confidence":0.9975595474243164,"confidence_rate":0.9999787529619484},{"cnt":[[245,1697],[1880,1697],[1880,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1697,"width":1636,"height":54},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"205ab34246c847a0bb2d9c6c0b7e420f","type":"text","conversion_output":true,"text":"with a higher incidence of grade 3 and 4 toxicities in patients. \\({ }^{97,98}\\) cis-RA may be subject to first-pass","text_display":" with a higher incidence of grade 3 and 4 toxicities in patients. \\({ }^{97,98}\\) cis-RA may be subject to first-pass","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1880,1749],[1880,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5fac43688904722876316d3fa820c83","type":"text","conversion_output":true,"text":"metabolism and subsequent plasma (and tumor) concentrations will depend on the rate of metabolism to","text_display":" metabolism and subsequent plasma (and tumor) concentrations will depend on the rate of metabolism to","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1880,1792],[1880,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1791,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"778fcae2a1a44b95bd84fc1d979110b2","type":"text","conversion_output":true,"text":"its inactive 4-oxo metabolite. Preliminary data from a pilot study in the UK (UKCCSG Study PK 2000","text_display":" its inactive 4-oxo metabolite. Preliminary data from a pilot study in the UK (UKCCSG Study PK 2000","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,1835],[1880,1835],[1880,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1834,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e59f8a86e9014be6bd2d96726ecc9ff9","type":"text","conversion_output":true,"text":"08 ) has shown that plasma concentrations of 4-oxo-13-cis-RA can accumulate to exceed those of the","text_display":" 08 ) has shown that plasma concentrations of 4-oxo-13-cis-RA can accumulate to exceed those of the","confidence":0.6635783499805257,"confidence_rate":0.9959874020100782},{"cnt":[[245,1878],[1880,1878],[1880,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1877,"width":1636,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a40ba379c3d24b2482c52aa5970aaf97","type":"text","conversion_output":true,"text":"parent compound. A \\(\\sim 10\\) - fold variation in 4-oxo-13-cis-RA peak plasma concentrations was found. It is","text_display":" parent compound. A \\(\\sim 10\\) - fold variation in 4-oxo-13-cis-RA peak plasma concentrations was found. It is","confidence":0.9553344357013884,"confidence_rate":0.9995846880354137},{"cnt":[[245,1919],[1824,1919],[1824,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1918,"width":1581,"height":53},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eccd7628f30140a0b0469b30424bd9f4","type":"text","conversion_output":true,"text":"proposed that increased levels of this metabolite in vivo may lead to a diminished efficacy of cis-RA. \\({ }^{99}\\)","text_display":" proposed that increased levels of this metabolite in vivo may lead to a diminished efficacy of cis-RA. \\({ }^{99}\\)","confidence":0.9926822170382366,"confidence_rate":0.9999366857175466},{"cnt":[[245,2002],[1880,2002],[1880,2047],[245,2047]],"region":{"top_left_x":244,"top_left_y":2002,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12f36cc0523f429c9fcf09b97385e249","type":"text","conversion_output":true,"text":"A number of cytochrome P450 (CYP) enzymes have been identified as playing a role in the metabolism","text_display":"\n\nA number of cytochrome P450 (CYP) enzymes have been identified as playing a role in the metabolism","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1880,2041],[1880,2090],[245,2090]],"region":{"top_left_x":244,"top_left_y":2041,"width":1636,"height":50},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55b59c6ce85649c38fad10d22aa304cc","type":"text","conversion_output":true,"text":"of cis-RA. \\({ }^{100,101}\\) CYP2C8 is most important in terms of activity and level of expression in the liver.","text_display":" of cis-RA. \\({ }^{100,101}\\) CYP2C8 is most important in terms of activity and level of expression in the liver.","confidence":1,"confidence_rate":1},{"cnt":[[245,2086],[1882,2086],[1882,2136],[245,2136]],"region":{"top_left_x":244,"top_left_y":2086,"width":1639,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aade5bb905ce42e297c2f84b81788d04","type":"text","conversion_output":true,"text":"Genetic polymorphisms in the CYP2C8 gene have been described \\({ }^{100}\\) which result in a lower rate of","text_display":" Genetic polymorphisms in the CYP2C8 gene have been described \\({ }^{100}\\) which result in a lower rate of","confidence":1,"confidence_rate":1},{"cnt":[[245,2127],[1880,2127],[1880,2181],[245,2181]],"region":{"top_left_x":244,"top_left_y":2126,"width":1636,"height":55},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ad1ccc8a105408ea48d8ca563fcf5fa","type":"text","conversion_output":true,"text":"paclitaxel metabolism and are commonly seen in a Caucasian population. \\({ }^{102,103}\\) Thus, genetic variation in","text_display":" paclitaxel metabolism and are commonly seen in a Caucasian population. \\({ }^{102,103}\\) Thus, genetic variation in","confidence":1,"confidence_rate":1},{"cnt":[[245,2179],[1880,2179],[1880,2224],[245,2224]],"region":{"top_left_x":244,"top_left_y":2178,"width":1636,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54fdbf51a1de418a88b4cfd2bb13278e","type":"text","conversion_output":true,"text":"CYP2C8 activity could underlie individual differences in cis-RA metabolism and bioavailability. The","text_display":" CYP2C8 activity could underlie individual differences in cis-RA metabolism and bioavailability. The","confidence":1,"confidence_rate":1},{"cnt":[[245,2221],[1880,2221],[1880,2267],[245,2267]],"region":{"top_left_x":244,"top_left_y":2221,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54e476f5b0a6429ea9d7f26310d72cb7","type":"text","conversion_output":true,"text":"fetal isoform CYP3A7, which is expressed post-natally in a significant number of individuals, also","text_display":" fetal isoform CYP3A7, which is expressed post-natally in a significant number of individuals, also","confidence":1,"confidence_rate":1},{"cnt":[[245,2262],[1880,2262],[1880,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2262,"width":1636,"height":52},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37a590918f5d408f926d00146459c205","type":"text","conversion_output":true,"text":"metabolizes cis-RA \\({ }^{100}\\). The expression of CYP3A7, and thus the contribution of this isoform to cis-RA","text_display":" metabolizes cis-RA \\({ }^{100}\\). The expression of CYP3A7, and thus the contribution of this isoform to cis-RA","confidence":0.9990234375,"confidence_rate":0.9999916492686468},{"cnt":[[245,2312],[1880,2312],[1880,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2311,"width":1636,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fec767a34e60412c822f4ebf8e92883b","type":"text","conversion_output":true,"text":"metabolism, may be predicted by genotyping in a pediatric population. A further aspect of cis-RA","text_display":" metabolism, may be predicted by genotyping in a pediatric population. A further aspect of cis-RA","confidence":1,"confidence_rate":1},{"cnt":[[245,2355],[1880,2355],[1880,2400],[245,2400]],"region":{"top_left_x":244,"top_left_y":2354,"width":1636,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc85f0aeb745447fa3565db1189660b6","type":"text","conversion_output":true,"text":"metabolism is glucuronidation, both of the parent drug and of 4-hydroxy-metabolites. This conjugation","text_display":" metabolism is glucuronidation, both of the parent drug and of 4-hydroxy-metabolites. This conjugation","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,2393],[1880,2393],[1880,2445],[245,2445]],"region":{"top_left_x":244,"top_left_y":2393,"width":1636,"height":52},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fdfbbdd8d6654b53a821ea1786745d3c","type":"text","conversion_output":true,"text":"may be mediated by UGT1A1 or UGT2B7, \\({ }^{104}\\) both enzymes that are subject to genetic polymorphisms. \\({ }^{105}\\)","text_display":" may be mediated by UGT1A1 or UGT2B7, \\({ }^{104}\\) both enzymes that are subject to genetic polymorphisms. \\({ }^{105}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,2443],[1880,2443],[1880,2490],[245,2490]],"region":{"top_left_x":244,"top_left_y":2442,"width":1636,"height":49},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"551acc8606e14902aa597db812f8f038","type":"text","conversion_output":true,"text":"Results from this study will provide an insight into whether modulation of cis-RA dosing according to","text_display":" Results from this study will provide an insight into whether modulation of cis-RA dosing according to","confidence":1,"confidence_rate":1},{"cnt":[[245,2488],[1880,2488],[1880,2533],[245,2533]],"region":{"top_left_x":244,"top_left_y":2487,"width":1636,"height":47},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60f08bf43377487aba331ccbde95b327","type":"text","conversion_output":true,"text":"blood levels achieved and/or genotype, could be used in future studies to optimize the treatment of high-","text_display":" blood levels achieved and/or genotype, could be used in future studies to optimize the treatment of high-","confidence":1,"confidence_rate":1},{"cnt":[[1749,2608],[1880,2608],[1880,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":132,"height":46},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32327e9868004e2ba9a82fe0d48a5308","type":"page_info","conversion_output":false,"text":"Page 27","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-028","page":28,"lines":[{"cnt":[[245,99],[614,99],[614,165],[245,165]],"region":{"top_left_x":244,"top_left_y":98,"width":371,"height":68},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"e37b18a218854a15b467181ddf9b8cbb","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,103],[1652,103],[1652,140],[653,140]],"region":{"top_left_x":653,"top_left_y":103,"width":1000,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f75bbda5022b46e380df9bd4fcf85597","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.6342198596179963,"confidence_rate":0.9943241736751942},{"cnt":[[1706,99],[1880,99],[1880,140],[1706,140]],"region":{"top_left_x":1705,"top_left_y":98,"width":175,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38771a0e94d04e59bd6f8ac1b1d455c4","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[322,168],[660,168],[660,213],[322,213]],"region":{"top_left_x":322,"top_left_y":167,"width":338,"height":46},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f2a2faa74d3e4e3da9124c68c966c64f","type":"authors","conversion_output":false,"children_ids":["b4ace54b1fc3433982075ad220968cc5"],"text":"","text_display":""},{"cnt":[[331,172],[655,172],[655,208],[331,208]],"region":{"top_left_x":330,"top_left_y":171,"width":326,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b4ace54b1fc3433982075ad220968cc5","type":"text","conversion_output":true,"parent_id":"f2a2faa74d3e4e3da9124c68c966c64f","text":"Children's Oncology Group","text_display":"\n\n\\author{\nChildren's Oncology Group\n}","confidence":1,"confidence_rate":1},{"cnt":[[243,228],[1880,228],[1880,273],[243,273]],"region":{"top_left_x":242,"top_left_y":227,"width":1638,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"423914ed435646a086a968eb69d756c6","type":"text","conversion_output":true,"text":"risk neuroblastoma. This study will be conducted in collaboration with the United Kingdom Children's","text_display":"\nrisk neuroblastoma. This study will be conducted in collaboration with the United Kingdom Children's","confidence":1,"confidence_rate":1},{"cnt":[[245,271],[767,271],[767,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":523,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a8775c206f642dcb275bef4ecb7cf61","type":"text","conversion_output":true,"text":"Cancer Study Group (UKCCSG).","text_display":" Cancer Study Group (UKCCSG).","confidence":1,"confidence_rate":1},{"cnt":[[241,352],[827,352],[827,408],[241,408]],"region":{"top_left_x":240,"top_left_y":352,"width":588,"height":57},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7904383d7c2e441e855478e9aeac0e03","type":"section_header","conversion_output":false,"children_ids":["0f80b72ddbdf406996445a938a3466b7"],"text":"","text_display":""},{"cnt":[[245,357],[823,357],[823,402],[245,402]],"region":{"top_left_x":244,"top_left_y":356,"width":579,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f80b72ddbdf406996445a938a3466b7","type":"text","conversion_output":true,"parent_id":"7904383d7c2e441e855478e9aeac0e03","text":"2.12.4 Topotecan Pharmacokinetics","text_display":"\n\n\\subsection*{2.12.4 Topotecan Pharmacokinetics}","confidence":1,"confidence_rate":1},{"cnt":[[245,404],[1880,404],[1880,449],[245,449]],"region":{"top_left_x":244,"top_left_y":403,"width":1636,"height":47},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25c481fad8284c24a94207513099231e","type":"text","conversion_output":true,"text":"Many individual pharmacokinetic studies of topotecan in children with cancer have been conducted, and","text_display":"\n\nMany individual pharmacokinetic studies of topotecan in children with cancer have been conducted, and","confidence":1,"confidence_rate":1},{"cnt":[[245,443],[1880,443],[1880,492],[245,492]],"region":{"top_left_x":244,"top_left_y":442,"width":1636,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f8e7744a36f4a31ad72f981dc358a6c","type":"text","conversion_output":true,"text":"results have shown wide interindividual variability in topotecan clearance. \\({ }^{42,45,49}\\) Due to the inherent","text_display":" results have shown wide interindividual variability in topotecan clearance. \\({ }^{42,45,49}\\) Due to the inherent","confidence":0.96923828125,"confidence_rate":0.9997374731801634},{"cnt":[[245,490],[1880,490],[1880,535],[245,535]],"region":{"top_left_x":244,"top_left_y":489,"width":1636,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"732fd83dc5e34a1490b9a5c4cda79312","type":"text","conversion_output":true,"text":"variability in topotecan disposition, investigators have used pharmacokinetically guided dosing to","text_display":" variability in topotecan disposition, investigators have used pharmacokinetically guided dosing to","confidence":1,"confidence_rate":1},{"cnt":[[245,533],[1884,533],[1884,578],[245,578]],"region":{"top_left_x":244,"top_left_y":532,"width":1641,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3874d8cfafb402b917f1cba3d6ca1fc","type":"text","conversion_output":true,"text":"individualize the topotecan dosage for each patient based upon their systemic clearance and the goals of","text_display":" individualize the topotecan dosage for each patient based upon their systemic clearance and the goals of","confidence":1,"confidence_rate":1},{"cnt":[[245,574],[1880,574],[1880,625],[245,625]],"region":{"top_left_x":244,"top_left_y":573,"width":1636,"height":53},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b04fecfb7ac4dc498fd9984887df6a2","type":"text","conversion_output":true,"text":"the clinical trial. The response rate for this approach has been promising. \\({ }^{106,107}\\) Although","text_display":" the clinical trial. The response rate for this approach has been promising. \\({ }^{106,107}\\) Although","confidence":1,"confidence_rate":1},{"cnt":[[245,623],[1880,623],[1880,668],[245,668]],"region":{"top_left_x":244,"top_left_y":623,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5024e93bedab4c6ebab0d92030d744cf","type":"text","conversion_output":true,"text":"pharmacokinetically guided topotecan is a promising approach to dosing topotecan, it has limitations and","text_display":" pharmacokinetically guided topotecan is a promising approach to dosing topotecan, it has limitations and","confidence":1,"confidence_rate":1},{"cnt":[[245,666],[1532,666],[1532,713],[245,713]],"region":{"top_left_x":244,"top_left_y":666,"width":1288,"height":48},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fca3084a6b04ab5a9e544ae37a5c670","type":"text","conversion_output":true,"text":"it is important to find ways to simplify the current pharmacokinetic dosing strategy.","text_display":" it is important to find ways to simplify the current pharmacokinetic dosing strategy.","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[1880,748],[1880,793],[245,793]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6477eb50d2bc4af3a1802cf5cc3b8865","type":"text","conversion_output":true,"text":"One approach would be to use a dosing model based upon patient specific covariates identified in a","text_display":"\n\nOne approach would be to use a dosing model based upon patient specific covariates identified in a","confidence":0.9970703125,"confidence_rate":0.9999715150908018},{"cnt":[[245,791],[1880,791],[1880,836],[245,836]],"region":{"top_left_x":244,"top_left_y":790,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6daac86c89db499f8b82ce5890290e05","type":"text","conversion_output":true,"text":"population pharmacokinetic analysis. Such an analysis of topotecan lactone pharmacokinetics has been","text_display":" population pharmacokinetic analysis. Such an analysis of topotecan lactone pharmacokinetics has been","confidence":1,"confidence_rate":1},{"cnt":[[245,834],[1878,834],[1878,879],[245,879]],"region":{"top_left_x":244,"top_left_y":833,"width":1634,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ea0038979c3436883d62ad783a6501d","type":"text","conversion_output":true,"text":"conducted in a large pediatric patient population, which includes patients with many different diagnoses.","text_display":" conducted in a large pediatric patient population, which includes patients with many different diagnoses.","confidence":1,"confidence_rate":1},{"cnt":[[245,877],[1880,877],[1880,922],[245,922]],"region":{"top_left_x":244,"top_left_y":876,"width":1636,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fd3052a606f4c7b832177e7c60bf946","type":"text","conversion_output":true,"text":"The covariates identified in this analysis included BSA, age, phenytoin coadministration, calculated","text_display":" The covariates identified in this analysis included BSA, age, phenytoin coadministration, calculated","confidence":1,"confidence_rate":1},{"cnt":[[245,922],[1880,922],[1880,969],[245,969]],"region":{"top_left_x":244,"top_left_y":921,"width":1636,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd35d8b84bdc45ef91ee39f4ff9d3691","type":"text","conversion_output":true,"text":"glomerular filtration rate, and serum creatinine. However, for the current application the patient","text_display":" glomerular filtration rate, and serum creatinine. However, for the current application the patient","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1880,967],[1880,1012],[245,1012]],"region":{"top_left_x":244,"top_left_y":966,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c099261e1e2d4f20bbe08e3137ec9cca","type":"text","conversion_output":true,"text":"population will be limited to children with high-risk neuroblastoma and only total topotecan (combination","text_display":" population will be limited to children with high-risk neuroblastoma and only total topotecan (combination","confidence":1,"confidence_rate":1},{"cnt":[[245,1010],[1880,1010],[1880,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1009,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"414459dcd1d749d99c7f98681d7bb416","type":"text","conversion_output":true,"text":"of lactone and carboxylate forms) will be available for pharmacokinetic analysis. Thus, a more limited","text_display":" of lactone and carboxylate forms) will be available for pharmacokinetic analysis. Thus, a more limited","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1880,1053],[1880,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1052,"width":1636,"height":51},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaa03166e884423880c104c697cf26e2","type":"text","conversion_output":true,"text":"population pharmacokinetic analysis was undertaken of the ANBL02P1 total topotecan plasma","text_display":" population pharmacokinetic analysis was undertaken of the ANBL02P1 total topotecan plasma","confidence":1,"confidence_rate":1},{"cnt":[[245,1096],[1880,1096],[1880,1143],[245,1143]],"region":{"top_left_x":244,"top_left_y":1095,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bf9a9c73b544c388ce37721cc08a2e7","type":"text","conversion_output":true,"text":"concentration-time data. In this analysis, the only patient covariate identified as significantly related to","text_display":" concentration-time data. In this analysis, the only patient covariate identified as significantly related to","confidence":1,"confidence_rate":1},{"cnt":[[245,1143],[1880,1143],[1880,1188],[245,1188]],"region":{"top_left_x":244,"top_left_y":1142,"width":1636,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c9ea49cfee940ecaad70e3ba2909def","type":"text","conversion_output":true,"text":"topotecan total clearance was sex with females having a lower clearance. Clearly this covariate will not","text_display":" topotecan total clearance was sex with females having a lower clearance. Clearly this covariate will not","confidence":1,"confidence_rate":1},{"cnt":[[245,1186],[1880,1186],[1880,1231],[245,1231]],"region":{"top_left_x":244,"top_left_y":1185,"width":1636,"height":47},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5bef615f793340b5b46df03e6e6dfc27","type":"text","conversion_output":true,"text":"be very informative in a dosing model. Thus, it would be helpful to gain additional covariate data in this","text_display":" be very informative in a dosing model. Thus, it would be helpful to gain additional covariate data in this","confidence":1,"confidence_rate":1},{"cnt":[[245,1229],[1878,1229],[1878,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1228,"width":1634,"height":47},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"879742d0adec4b04a4c88012c48b2e24","type":"text","conversion_output":true,"text":"patient population, and relate that to total topotecan clearance determined using a limited sampling model.","text_display":" patient population, and relate that to total topotecan clearance determined using a limited sampling model.","confidence":1,"confidence_rate":1},{"cnt":[[245,1272],[1880,1272],[1880,1319],[245,1319]],"region":{"top_left_x":244,"top_left_y":1271,"width":1636,"height":49},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db4a510f6b2e44f1982dd37996395cf5","type":"text","conversion_output":true,"text":"Ultimately, data collected in this Phase III clinical trial will be used to derive a dosing algorithm for","text_display":" Ultimately, data collected in this Phase III clinical trial will be used to derive a dosing algorithm for","confidence":1,"confidence_rate":1},{"cnt":[[245,1317],[1880,1317],[1880,1364],[245,1364]],"region":{"top_left_x":244,"top_left_y":1316,"width":1636,"height":49},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbb17f1113d54678b3de97bdb7626916","type":"text","conversion_output":true,"text":"topotecan in children with high-risk neuroblastoma that will either not need plasma topotecan","text_display":" topotecan in children with high-risk neuroblastoma that will either not need plasma topotecan","confidence":1,"confidence_rate":1},{"cnt":[[245,1362],[1880,1362],[1880,1407],[245,1407]],"region":{"top_left_x":244,"top_left_y":1362,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2ede706366844e2a331f96dcfed5788","type":"text","conversion_output":true,"text":"concentrations or at most use only one plasma concentration. By using this dosing model, the interpatient","text_display":" concentrations or at most use only one plasma concentration. By using this dosing model, the interpatient","confidence":1,"confidence_rate":1},{"cnt":[[245,1405],[1880,1405],[1880,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"358e015da0bf47debc38b7f7dfbd7b70","type":"text","conversion_output":true,"text":"variability in topotecan systemic exposure can be minimized, and the full therapeutic efficacy of this","text_display":" variability in topotecan systemic exposure can be minimized, and the full therapeutic efficacy of this","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,1448],[662,1448],[662,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1448,"width":418,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"503a3a503b034cd5b7e9e6b2be409e8d","type":"text","conversion_output":true,"text":"compound can be realized.","text_display":" compound can be realized.","confidence":1,"confidence_rate":1},{"cnt":[[241,1525],[1098,1525],[1098,1579],[241,1579]],"region":{"top_left_x":240,"top_left_y":1525,"width":858,"height":55},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ecff78000e244328abe84992cae0aaf","type":"section_header","conversion_output":false,"children_ids":["da271c282605427aa0e98e7e749dcbe4"],"text":"","text_display":""},{"cnt":[[245,1530],[1094,1530],[1094,1573],[245,1573]],"region":{"top_left_x":244,"top_left_y":1529,"width":850,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da271c282605427aa0e98e7e749dcbe4","type":"text","conversion_output":true,"parent_id":"6ecff78000e244328abe84992cae0aaf","text":"2.12.5 Cellular Immune Responses to Neuroblastoma","text_display":"\n\n\\subsection*{2.12.5 Cellular Immune Responses to Neuroblastoma}","confidence":0.99560546875,"confidence_rate":0.9999184437780202},{"cnt":[[245,1573],[1880,1573],[1880,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1572,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64a8eec9a9a14b0789c66e3f5faf5e29","type":"text","conversion_output":true,"text":"Despite low or absent expression of MHC class I, T cells capable of recognizing neuroblastoma cells and","text_display":"\n\nDespite low or absent expression of MHC class I, T cells capable of recognizing neuroblastoma cells and","confidence":1,"confidence_rate":1},{"cnt":[[245,1616],[1880,1616],[1880,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1615,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89b98b3723874f878e8b047f71d4f56f","type":"text","conversion_output":true,"text":"acting as effector cells have been described. Survivin has the potential to be a relevant tumor antigen in","text_display":" acting as effector cells have been described. Survivin has the potential to be a relevant tumor antigen in","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,1654],[1880,1654],[1880,1706],[245,1706]],"region":{"top_left_x":244,"top_left_y":1654,"width":1636,"height":52},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"101693a252b349fb8ab09e12e8b57397","type":"text","conversion_output":true,"text":"neuroblastoma, as it is widely expressed \\({ }^{108}\\) and expression is inversely correlated with prognosis. \\({ }^{109}\\)","text_display":" neuroblastoma, as it is widely expressed \\({ }^{108}\\) and expression is inversely correlated with prognosis. \\({ }^{109}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1880,1706],[1880,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1705,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82c7bb8e15a84266b7789e8934865beb","type":"text","conversion_output":true,"text":"Moreover, as a key inhibitor of apoptosis, survivin may be required for tumor growth and development,","text_display":" Moreover, as a key inhibitor of apoptosis, survivin may be required for tumor growth and development,","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1880,1749],[1880,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"899e5ec69b1842aca2a39ebef16055fd","type":"text","conversion_output":true,"text":"making its potential loss as a means of escape of the tumor from immune surveillance difficult. We","text_display":" making its potential loss as a means of escape of the tumor from immune surveillance difficult. We","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1880,1792],[1880,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1791,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f8799b7f09f433295efa2a9fc4e1a66","type":"text","conversion_output":true,"text":"hypothesize that cytolytic T lymphocytes (CTL) directed against survivin+ targets will be detectable in","text_display":" hypothesize that cytolytic T lymphocytes (CTL) directed against survivin+ targets will be detectable in","confidence":0.98486328125,"confidence_rate":0.9998587835997044},{"cnt":[[245,1835],[1880,1835],[1880,1882],[245,1882]],"region":{"top_left_x":244,"top_left_y":1834,"width":1636,"height":49},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3173d9da0df44b058dfe1ff507954186","type":"text","conversion_output":true,"text":"the blood of neuroblastoma patients. Additionally, these CTL will be expanded by exposure to two","text_display":" the blood of neuroblastoma patients. Additionally, these CTL will be expanded by exposure to two","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1880,1878],[1880,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1877,"width":1636,"height":51},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86398480c2d44fbfaaa1acab9c0a9680","type":"text","conversion_output":true,"text":"different preparations of antigen presenting cells (APCs). One APC type will be transfected with survivin","text_display":" different preparations of antigen presenting cells (APCs). One APC type will be transfected with survivin","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[245,1925],[1880,1925],[1880,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60792528a30f4e41978657d7183b072a","type":"text","conversion_output":true,"text":"mRNA, providing surviving peptides to the MHC of the APC, while the second APC type will be loaded","text_display":" mRNA, providing surviving peptides to the MHC of the APC, while the second APC type will be loaded","confidence":0.9576379208868957,"confidence_rate":0.9995798404703998},{"cnt":[[245,1968],[1880,1968],[1880,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1967,"width":1636,"height":47},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb8506edf92e4586af6067f1d287a311","type":"text","conversion_output":true,"text":"with neuroblastoma RNA. The APC used in our studies has been an activated B cell, referred to as a","text_display":" with neuroblastoma RNA. The APC used in our studies has been an activated B cell, referred to as a","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1880,2007],[1880,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1636,"height":51},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"334e50c433414fa784120c7bb90ea9ec","type":"text","conversion_output":true,"text":"CD40-B. Relevant prior work from the Grupp and Vonderheide labs \\({ }^{110}\\) show that: 1) CD40-B cells serve","text_display":" CD40-B. Relevant prior work from the Grupp and Vonderheide labs \\({ }^{110}\\) show that: 1) CD40-B cells serve","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,2054],[1880,2054],[1880,2101],[245,2101]],"region":{"top_left_x":244,"top_left_y":2053,"width":1636,"height":49},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef499ae16e7d4fbb80870e124f3987da","type":"text","conversion_output":true,"text":"as efficient APCs, inducing antigen-specific and anti-tumor CTL. 2) Large numbers of CD40-B APCs can","text_display":" as efficient APCs, inducing antigen-specific and anti-tumor CTL. 2) Large numbers of CD40-B APCs can","confidence":1,"confidence_rate":1},{"cnt":[[245,2099],[1878,2099],[1878,2144],[245,2144]],"region":{"top_left_x":244,"top_left_y":2099,"width":1634,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9230acbce312453fa11df6c236c75781","type":"text","conversion_output":true,"text":"be grown from small volumes of peripheral blood, as opposed to dendritic cells, which require pheresis to","text_display":" be grown from small volumes of peripheral blood, as opposed to dendritic cells, which require pheresis to","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1880,2144],[1880,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1636,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee3cc73f12bc4d5ca73f7532865cad50","type":"text","conversion_output":true,"text":"collect in adequate numbers. 3) RNA transfection efficiently transduces CD40-B APC, allowing","text_display":" collect in adequate numbers. 3) RNA transfection efficiently transduces CD40-B APC, allowing","confidence":1,"confidence_rate":1},{"cnt":[[245,2187],[1880,2187],[1880,2232],[245,2232]],"region":{"top_left_x":244,"top_left_y":2187,"width":1636,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ea7392078c54ce0a1272290a5785115","type":"text","conversion_output":true,"text":"expansion of tumor-specific CTL from patient blood samples even in a tumor like neuroblastoma in","text_display":" expansion of tumor-specific CTL from patient blood samples even in a tumor like neuroblastoma in","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,2230],[1880,2230],[1880,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2230,"width":1636,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b15da80f23ae414db1cd07e5f53e3074","type":"text","conversion_output":true,"text":"which tumor antigens are not known. 4) Neuroblastoma expresses survivin. 5) Survivin-specific CTL can","text_display":" which tumor antigens are not known. 4) Neuroblastoma expresses survivin. 5) Survivin-specific CTL can","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1880,2273],[1880,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1636,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ae21bb2e667432db725bf105fd1f767","type":"text","conversion_output":true,"text":"be detected at diagnosis in up to \\(50 \\%\\) of neuroblastoma patients and expanded using either survivin-","text_display":" be detected at diagnosis in up to \\(50 \\%\\) of neuroblastoma patients and expanded using either survivin","confidence":0.99462890625,"confidence_rate":0.9999496688373789},{"cnt":[[245,2316],[1880,2316],[1880,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":1636,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3cf405fe0fba43f3a15b0091a5a49cff","type":"text","conversion_output":true,"text":"transfected CD40-B or CD40-B transfected with neuroblastoma RNA. \\({ }^{110}\\) Iinitial studies demonstrate that","text_display":"transfected CD40-B or CD40-B transfected with neuroblastoma RNA. \\({ }^{110}\\) Iinitial studies demonstrate that","confidence":0.9727058410644531,"confidence_rate":0.9997635017810216},{"cnt":[[245,2361],[1880,2361],[1880,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2361,"width":1636,"height":48},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ae07862b82b4539b51ef63eaf8d03f9","type":"text","conversion_output":true,"text":"T cells active against survivin+ targets emerge whether survivin RNA or whole tumor RNA is used as the","text_display":" T cells active against survivin+ targets emerge whether survivin RNA or whole tumor RNA is used as the","confidence":0.6915566921234131,"confidence_rate":0.9965591096745622},{"cnt":[[245,2406],[1880,2406],[1880,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2406,"width":1636,"height":46},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"283843047f59400e80be26bf45de399f","type":"text","conversion_output":true,"text":"antigenic stimulus. 6) Survivin-specific CTL secretes IFN-gamma in response to tumor and effectively","text_display":" antigenic stimulus. 6) Survivin-specific CTL secretes IFN-gamma in response to tumor and effectively","confidence":1,"confidence_rate":1},{"cnt":[[245,2445],[1880,2445],[1880,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2444,"width":1636,"height":55},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55eb04d48f3e4b8b8ace083fa6cdef1d","type":"text","conversion_output":true,"text":"lyse survivin+ neuroblastoma targets. 7) CD107a is a marker of CTL function \\({ }^{111}\\) and can also be used to","text_display":" lyse survivin+ neuroblastoma targets. 7) CD107a is a marker of CTL function \\({ }^{111}\\) and can also be used to","confidence":1,"confidence_rate":1},{"cnt":[[245,2496],[1878,2496],[1878,2542],[245,2542]],"region":{"top_left_x":244,"top_left_y":2496,"width":1634,"height":46},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6edd1788d975453cac47c967ad79b07b","type":"text","conversion_output":true,"text":"demonstrate that CTL specific for the immunodominant epitope of survivin are responsible for anti-","text_display":" demonstrate that CTL specific for the immunodominant epitope of survivin are responsible for anti","confidence":1,"confidence_rate":1},{"cnt":[[245,2539],[720,2539],[720,2585],[245,2585]],"region":{"top_left_x":244,"top_left_y":2539,"width":476,"height":46},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6c6bf3294734cc8b4dc54b25938a2ef","type":"text","conversion_output":true,"text":"neuroblastoma killing activity.","text_display":"neuroblastoma killing activity.","confidence":1,"confidence_rate":1},{"cnt":[[1749,2608],[1876,2608],[1876,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":128,"height":46},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccda892aa1c14af884ec49926b33aa37","type":"page_info","conversion_output":false,"text":"Page 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POLICY","text_display":"","confidence":0.7272742825119186,"confidence_rate":0.9960272673564858},{"cnt":[[1706,103],[1876,103],[1876,135],[1706,135]],"region":{"top_left_x":1705,"top_left_y":103,"width":171,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c27efab95d5e453286e75ec846e314b0","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,176],[651,176],[651,208],[331,208]],"region":{"top_left_x":330,"top_left_y":176,"width":321,"height":33},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"de0b1868096b48778408e77837d27092","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,271],[1880,271],[1880,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":1636,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe6bfc8158834aebb4cb578e5d0780e0","type":"text","conversion_output":true,"text":"These data point to survivin as an important tumor antigen in neuroblastoma, show feasibility of using","text_display":"\n\nThese data point to survivin as an important tumor antigen in neuroblastoma, show feasibility of using","confidence":1,"confidence_rate":1},{"cnt":[[245,318],[1880,318],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":317,"width":1636,"height":47},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02a692b24c284b0bb3c36ada634f0ec8","type":"text","conversion_output":true,"text":"tumor RNA to provide an antigenic payload to APCs and confirm that neuroblastoma is a tumor","text_display":" tumor RNA to provide an antigenic payload to APCs and confirm that neuroblastoma is a tumor","confidence":1,"confidence_rate":1},{"cnt":[[245,361],[1880,361],[1880,404],[245,404]],"region":{"top_left_x":244,"top_left_y":360,"width":1636,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1a57139ae9348058feb11dde3a0ba7a","type":"text","conversion_output":true,"text":"susceptible to immune recognition. Data revealing tumor RNA-loaded APC produce tetramer+ CTL","text_display":" susceptible to immune recognition. Data revealing tumor RNA-loaded APC produce tetramer+ CTL","confidence":1,"confidence_rate":1},{"cnt":[[245,404],[1878,404],[1878,449],[245,449]],"region":{"top_left_x":244,"top_left_y":403,"width":1634,"height":47},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"633d34290eb24a31908c0b04b88e5f6b","type":"text","conversion_output":true,"text":"directed against survivin that are capable lysing autologous tumor provides key evidence of the","text_display":" directed against survivin that are capable lysing autologous tumor provides key evidence of the","confidence":1,"confidence_rate":1},{"cnt":[[245,447],[1882,447],[1882,492],[245,492]],"region":{"top_left_x":244,"top_left_y":446,"width":1639,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75116cc764784178b22ad27bde7374e2","type":"text","conversion_output":true,"text":"importance of survivin in neuroblastoma. These results need to be confirmed in the larger number of","text_display":" importance of survivin in neuroblastoma. These results need to be confirmed in the larger number of","confidence":1,"confidence_rate":1},{"cnt":[[245,490],[1880,490],[1880,535],[245,535]],"region":{"top_left_x":244,"top_left_y":489,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7efab1bd450349b9841fb652d8d678e2","type":"text","conversion_output":true,"text":"samples available from the patients on this clinical trial. These experiments will allow us to further","text_display":" samples available from the patients on this clinical trial. These experiments will allow us to further","confidence":1,"confidence_rate":1},{"cnt":[[245,535],[1287,535],[1287,580],[245,580]],"region":{"top_left_x":244,"top_left_y":534,"width":1043,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7bf877787fe4e4082d09217b0d1f33d","type":"text","conversion_output":true,"text":"characterize survivin as a potential tumor antigen in neuroblastoma.","text_display":" characterize survivin as a potential tumor antigen in neuroblastoma.","confidence":1,"confidence_rate":1},{"cnt":[[243,612],[1210,612],[1210,664],[243,664]],"region":{"top_left_x":242,"top_left_y":612,"width":968,"height":52},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29c20bcea7bb4b8d968678cfec8ca5bd","type":"section_header","conversion_output":false,"children_ids":["76559c7e1c944e249ce82be8a3accaa1"],"text":"","text_display":""},{"cnt":[[245,614],[1205,614],[1205,660],[245,660]],"region":{"top_left_x":244,"top_left_y":614,"width":962,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76559c7e1c944e249ce82be8a3accaa1","type":"text","conversion_output":true,"parent_id":"29c20bcea7bb4b8d968678cfec8ca5bd","text":"2.12.6 Cellular Immunity after Myeloablative Chemotherapy","text_display":"\n\n\\subsection*{2.12.6 Cellular Immunity after Myeloablative Chemotherapy}","confidence":0.99951171875,"confidence_rate":0.999992122603638},{"cnt":[[245,660],[1876,660],[1876,703],[245,703]],"region":{"top_left_x":244,"top_left_y":659,"width":1632,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c806318043544f2d9497bdffbfc795d6","type":"text","conversion_output":true,"text":"Increasing intensity of therapy has the potential to increase extent and duration of immune suppression,","text_display":"\n\nIncreasing intensity of therapy has the potential to increase extent and duration of immune suppression,","confidence":1,"confidence_rate":1},{"cnt":[[245,698],[1878,698],[1878,748],[245,748]],"region":{"top_left_x":244,"top_left_y":698,"width":1634,"height":50},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e2c8eff6d484155a1e2272db5ba6519","type":"text","conversion_output":true,"text":"especially of adaptive immunity. This was apparent in the CHOP/DFCI tandem HSCT experience \\({ }^{27}\\) where","text_display":" especially of adaptive immunity. This was apparent in the CHOP/DFCI tandem HSCT experience \\({ }^{27}\\) where","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[1880,748],[1880,793],[245,793]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19b3260c2cbc4652801db6d137917283","type":"text","conversion_output":true,"text":"a combination of tandem HSCT, use of TBI and, potentially, use of CD34 selection of PBSC produced","text_display":" a combination of tandem HSCT, use of TBI and, potentially, use of CD34 selection of PBSC produced","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[1878,786],[1878,840],[245,840]],"region":{"top_left_x":244,"top_left_y":786,"width":1634,"height":55},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67f6d19ae7f242f2b32d3111a194d5c6","type":"text","conversion_output":true,"text":"significant T cell immune suppression. \\({ }^{112}\\) We hypothesize that patients on the tandem HSCT arm will","text_display":" significant T cell immune suppression. \\({ }^{112}\\) We hypothesize that patients on the tandem HSCT arm will","confidence":0.8203754425048828,"confidence_rate":0.9983514171847271},{"cnt":[[245,838],[1878,838],[1878,883],[245,883]],"region":{"top_left_x":244,"top_left_y":837,"width":1634,"height":47},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4400046efa864a7e94c83cf9dcf4e30a","type":"text","conversion_output":true,"text":"experience slower T cell recovery, specifically of CD4+ T cells. Enumeration of CD3, CD4 and CD8","text_display":" experience slower T cell recovery, specifically of CD4+ T cells. Enumeration of CD3, CD4 and CD8","confidence":0.9990236759185791,"confidence_rate":0.9999903287497746},{"cnt":[[245,883],[1880,883],[1880,928],[245,928]],"region":{"top_left_x":244,"top_left_y":883,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c7fc015fd6a4195b1869b2a28ed35c7","type":"text","conversion_output":true,"text":"cells post HSCT is available at all FACT-approved HSCT centers, and is part of post-HSCT routine","text_display":" cells post HSCT is available at all FACT-approved HSCT centers, and is part of post-HSCT routine","confidence":1,"confidence_rate":1},{"cnt":[[245,924],[1880,924],[1880,971],[245,971]],"region":{"top_left_x":244,"top_left_y":923,"width":1636,"height":49},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"724a23b3cba041eca7534b443418b945","type":"text","conversion_output":true,"text":"follow up at many centers. There is also value in following CD4 recovery to guide the level of viral","text_display":" follow up at many centers. There is also value in following CD4 recovery to guide the level of viral","confidence":1,"confidence_rate":1},{"cnt":[[245,971],[1878,971],[1878,1016],[245,1016]],"region":{"top_left_x":244,"top_left_y":971,"width":1634,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"786ca740c53c45c2969bcbb8331eb39d","type":"text","conversion_output":true,"text":"surveillance and isolation precautions that may or may not be required for an individual patient. Thus, we","text_display":" surveillance and isolation precautions that may or may not be required for an individual patient. Thus, we","confidence":1,"confidence_rate":1},{"cnt":[[245,1014],[1878,1014],[1878,1059],[245,1059]],"region":{"top_left_x":244,"top_left_y":1014,"width":1634,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0129568e61ee459f9ff618d78094867e","type":"text","conversion_output":true,"text":"propose to perform these assays at 1,3 and 6 months post-HSCT, comparing T cell recovery across arms","text_display":" propose to perform these assays at 1,3 and 6 months post-HSCT, comparing T cell recovery across arms","confidence":0.808476448059082,"confidence_rate":0.9980864841840502},{"cnt":[[245,1057],[1876,1057],[1876,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1057,"width":1632,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91fbd5eed72e4cf6bccc560158db1e02","type":"text","conversion_output":true,"text":"of the study. These assessments will provide a valuable baseline for studies that may utilize either of the","text_display":" of the study. These assessments will provide a valuable baseline for studies that may utilize either of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1102],[1878,1102],[1878,1147],[245,1147]],"region":{"top_left_x":244,"top_left_y":1102,"width":1634,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2deec6bcc98441aba4daaccd8abca5b4","type":"text","conversion_output":true,"text":"ANBL0532 regimens, especially in the context of immunotherapies that may require functional T cell","text_display":" ANBL0532 regimens, especially in the context of immunotherapies that may require functional T cell","confidence":0.9790744129568338,"confidence_rate":0.9998060038638017},{"cnt":[[245,1152],[393,1152],[393,1190],[245,1190]],"region":{"top_left_x":244,"top_left_y":1151,"width":150,"height":40},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b007a8cf51b428cbecd15f7c048ad9a","type":"text","conversion_output":true,"text":"recovery.","text_display":" recovery.","confidence":1,"confidence_rate":1},{"cnt":[[245,1225],[784,1225],[784,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1224,"width":541,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"557f9f3538a6429ca6c06edded421025","type":"section_header","conversion_output":false,"children_ids":["8deeef05630349a0a86dc00104b86303"],"text":"","text_display":""},{"cnt":[[247,1229],[780,1229],[780,1265],[247,1265]],"region":{"top_left_x":247,"top_left_y":1228,"width":533,"height":38},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8deeef05630349a0a86dc00104b86303","type":"text","conversion_output":true,"parent_id":"557f9f3538a6429ca6c06edded421025","text":"2.12.7 Minimal Residual Disease","text_display":"\n\n\\subsection*{2.12.7 Minimal Residual Disease}","confidence":1,"confidence_rate":1},{"cnt":[[247,1272],[1878,1272],[1878,1315],[247,1315]],"region":{"top_left_x":247,"top_left_y":1271,"width":1631,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bfae4b9f6624033a764e369547c5175","type":"text","conversion_output":true,"text":"Despite initial response to therapy, the majority of children with high-risk neuroblastoma will develop","text_display":"\n\nDespite initial response to therapy, the majority of children with high-risk neuroblastoma will develop","confidence":1,"confidence_rate":1},{"cnt":[[245,1315],[1880,1315],[1880,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1314,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b46a33e24034f29b097673171f427f0","type":"text","conversion_output":true,"text":"recurrent or progressive disease. More sensitive methods for the detection of minimal residual disease","text_display":" recurrent or progressive disease. More sensitive methods for the detection of minimal residual disease","confidence":1,"confidence_rate":1},{"cnt":[[247,1354],[1880,1354],[1880,1403],[247,1403]],"region":{"top_left_x":247,"top_left_y":1353,"width":1633,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af33cf168b45444b9b72037be8703415","type":"text","conversion_output":true,"text":"(MRD) are needed. Several reports demonstrated the high sensitivity ( \\(1 \\times 10^{-4}\\) to \\(10^{-6}\\) normal cells) of","text_display":" (MRD) are needed. Several reports demonstrated the high sensitivity ( \\(1 \\times 10^{-4}\\) to \\(10^{-6}\\) normal cells) of","confidence":0.9990234375,"confidence_rate":0.9999922457471451},{"cnt":[[245,1396],[1878,1396],[1878,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1634,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"315575862d044437834705b79fd29d65","type":"text","conversion_output":true,"text":"immunocytological assays in bone marrow, \\({ }^{113-115}\\) bone marrow autograft \\({ }^{116}\\) and peripheral blood","text_display":" immunocytological assays in bone marrow, \\({ }^{113-115}\\) bone marrow autograft \\({ }^{116}\\) and peripheral blood","confidence":1,"confidence_rate":1},{"cnt":[[245,1437],[1878,1437],[1878,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1437,"width":1634,"height":52},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45e9298c249445fc81d343b108e484bb","type":"text","conversion_output":true,"text":"samples. \\({ }^{117}\\) Quantitative levels of bone marrow infiltration using immunocytological assays have been","text_display":" samples. \\({ }^{117}\\) Quantitative levels of bone marrow infiltration using immunocytological assays have been","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[1878,1482],[1878,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1482,"width":1634,"height":55},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b85711b4bae24a9bbfdc9295982844ae","type":"text","conversion_output":true,"text":"predictive of outcome for patients with stage 3 and 4 disease. \\({ }^{118,119}\\). More recently amplification of tissue-","text_display":" predictive of outcome for patients with stage 3 and 4 disease. \\({ }^{118,119}\\). More recently amplification of tissue","confidence":1,"confidence_rate":1},{"cnt":[[245,1534],[1880,1534],[1880,1577],[245,1577]],"region":{"top_left_x":244,"top_left_y":1533,"width":1636,"height":44},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3bdc65af69a405781749a4f2903beff","type":"text","conversion_output":true,"text":"specific mRNA by reverse transcriptase polymerase chain reaction (RT-PCR) has been used to detect","text_display":"specific mRNA by reverse transcriptase polymerase chain reaction (RT-PCR) has been used to detect","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1878,1573],[1878,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1572,"width":1634,"height":51},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d621169e3ee34e4ebfb2f69fba3d19f8","type":"text","conversion_output":true,"text":"minimal disease burden (reviewed in \\({ }^{120}\\) ). Investigators have employed an RT-PCR assay, using both","text_display":" minimal disease burden (reviewed in \\({ }^{120}\\) ). Investigators have employed an RT-PCR assay, using both","confidence":1,"confidence_rate":1},{"cnt":[[245,1620],[1880,1620],[1880,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1619,"width":1636,"height":47},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92922b471b7d44ff97a9260208fd2d65","type":"text","conversion_output":true,"text":"tyrosine hydroxylase (TH) and the neuronal gene (PGP 9.5) which has a sensitivity of 1 tumor cell per","text_display":" tyrosine hydroxylase (TH) and the neuronal gene (PGP 9.5) which has a sensitivity of 1 tumor cell per","confidence":0.9931671619415283,"confidence_rate":0.9999371002463384},{"cnt":[[245,1661],[1876,1661],[1876,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1660,"width":1632,"height":49},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68228583e3bc4fcebf6e42495af46be0","type":"text","conversion_output":true,"text":"million hematopoietic cells. \\({ }^{121}\\) Although IC and RT-PCR appear to be ideal tools for monitoring MRD,","text_display":" million hematopoietic cells. \\({ }^{121}\\) Although IC and RT-PCR appear to be ideal tools for monitoring MRD,","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1878,1706],[1878,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1705,"width":1634,"height":51},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6cb7cf406ddd4f25b9e0867e0f65638c","type":"text","conversion_output":true,"text":"reaching a sensitivity of one tumor cell detected in \\(1 \\times 10^{5}\\) to \\(10^{6}\\) normal cells, their introduction into","text_display":" reaching a sensitivity of one tumor cell detected in \\(1 \\times 10^{5}\\) to \\(10^{6}\\) normal cells, their introduction into","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[1878,1753],[1878,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1753,"width":1634,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3a4303786a7491b8a130bcde0c8da68","type":"text","conversion_output":true,"text":"clinical management of children with neuroblastoma has been slow. ANBL0532 will evaluate the clinical","text_display":" clinical management of children with neuroblastoma has been slow. ANBL0532 will evaluate the clinical","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,1796],[1878,1796],[1878,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1796,"width":1634,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e75a4c9c8b442a9a7ffbaa291e9eaf6","type":"text","conversion_output":true,"text":"relevance of tumor cells detected by these techniques. Immunocytology and RT-PCR studies will be used","text_display":" relevance of tumor cells detected by these techniques. Immunocytology and RT-PCR studies will be used","confidence":1,"confidence_rate":1},{"cnt":[[245,1841],[1880,1841],[1880,1886],[245,1886]],"region":{"top_left_x":244,"top_left_y":1841,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77cd06f7e3064b539b3167d9bf8356ad","type":"text","conversion_output":true,"text":"on bone marrow, peripheral blood, and PBSC collections to examine the question of tumor","text_display":" on bone marrow, peripheral blood, and PBSC collections to examine the question of tumor","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1880,1886],[1880,1931],[245,1931]],"region":{"top_left_x":244,"top_left_y":1886,"width":1636,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db915bee7e8b4700a09794b5c6a72eae","type":"text","conversion_output":true,"text":"contamination. The incidence of RT-PCR positivity in stem cell products infused will be prospectively","text_display":" contamination. The incidence of RT-PCR positivity in stem cell products infused will be prospectively","confidence":1,"confidence_rate":1},{"cnt":[[245,1929],[1878,1929],[1878,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1929,"width":1634,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"907f1c3f759242aaa3192b16f611c763","type":"text","conversion_output":true,"text":"monitored. Furthermore, the incidence of RT-PCR positivity in bone marrow and peripheral blood will","text_display":" monitored. Furthermore, the incidence of RT-PCR positivity in bone marrow and peripheral blood will","confidence":1,"confidence_rate":1},{"cnt":[[245,1972],[1755,1972],[1755,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1972,"width":1512,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b67938f69fb34115aa9547b9e5ec7848","type":"text","conversion_output":true,"text":"be compared following consolidation therapy between single verus tandem myeloablative therapy.","text_display":" be compared following consolidation therapy between single verus tandem myeloablative therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,2050],[857,2050],[857,2093],[245,2093]],"region":{"top_left_x":244,"top_left_y":2049,"width":614,"height":44},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1645a94ec3b44b2bce6b13cad34e08c","type":"section_header","conversion_output":false,"children_ids":["4fd8dee7d7c54540b82ba80a083f11ce"],"text":"","text_display":""},{"cnt":[[247,2054],[853,2054],[853,2090],[247,2090]],"region":{"top_left_x":247,"top_left_y":2053,"width":606,"height":38},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fd8dee7d7c54540b82ba80a083f11ce","type":"text","conversion_output":true,"parent_id":"f1645a94ec3b44b2bce6b13cad34e08c","text":"2.13 Gender and Race Differences","text_display":"\n\n\\subsection*{2.13 Gender and Race Differences}","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1880,2097],[1880,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1636,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f997ecc4bf7d44a78c3478102b7867e8","type":"text","conversion_output":true,"text":"In CCG-3891, stage at diagnosis and EFS were similar between genders, however there was a trend for","text_display":"\n\nIn CCG-3891, stage at diagnosis and EFS were similar between genders, however there was a trend for","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1878,2140],[1878,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2139,"width":1634,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af99c612ed45446b9e88cabfea1c172f","type":"text","conversion_output":true,"text":"males to have better EFS than females on the ABMT arm of the study. There was a significant interactive","text_display":" males to have better EFS than females on the ABMT arm of the study. There was a significant interactive","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,2183],[1878,2183],[1878,2228],[245,2228]],"region":{"top_left_x":244,"top_left_y":2182,"width":1634,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9e7e0d17e52466e8b40156a92b2adee","type":"text","conversion_output":true,"text":"effect, in which the benefit of ABMT was restricted to males. No differences in outcome by gender were","text_display":" effect, in which the benefit of ABMT was restricted to males. No differences in outcome by gender were","confidence":1,"confidence_rate":1},{"cnt":[[245,2228],[1878,2228],[1878,2273],[245,2273]],"region":{"top_left_x":244,"top_left_y":2227,"width":1634,"height":47},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"714635a9093646dca94143c3482f6179","type":"text","conversion_output":true,"text":"observed in the earlier 321P3 transplant study. There were no differences on CCG-3891 with respect to","text_display":" observed in the earlier 321P3 transplant study. There were no differences on CCG-3891 with respect to","confidence":1,"confidence_rate":1},{"cnt":[[245,2273],[1878,2273],[1878,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2273,"width":1634,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ddf0addb77e47fa98af6ea3b0b8287e","type":"text","conversion_output":true,"text":"gender, regarding the effect of 13-cis-RA on EFS. Data from CCG-3891 also showed a lower overall","text_display":" gender, regarding the effect of 13-cis-RA on EFS. Data from CCG-3891 also showed a lower overall","confidence":0.95166015625,"confidence_rate":0.9995095531138396},{"cnt":[[245,2316],[1878,2316],[1878,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":1634,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"207d3eab67964f32bf525aaa4faaaea4","type":"text","conversion_output":true,"text":"EFS for African Americans versus Whites or Hispanics. African Americans had equivalent outcome on","text_display":" EFS for African Americans versus Whites or Hispanics. African Americans had equivalent outcome on","confidence":1,"confidence_rate":1},{"cnt":[[245,2359],[1878,2359],[1878,2404],[245,2404]],"region":{"top_left_x":244,"top_left_y":2358,"width":1634,"height":47},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57b8bc32b228413a9f542a3f1cb03f0a","type":"text","conversion_output":true,"text":"the ABMT arm, but lower EFS if treated on the chemotherapy arm in comparison with Whites. No ethnic","text_display":" the ABMT arm, but lower EFS if treated on the chemotherapy arm in comparison with Whites. 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The ANBL0532 study has previously mandated immunocytology assessment of","text_display":" chemotherapy. The ANBL0532 study has previously mandated immunocytology assessment of","confidence":1,"confidence_rate":1},{"cnt":[[245,357],[1880,357],[1880,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":1636,"height":51},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db6c4b99c9bc49e3a5fab464bbe043a7","type":"text","conversion_output":true,"text":"peripheral blood stem cell (PBSC) product for tumor contamination. The laboratory at Children's","text_display":" peripheral blood stem cell (PBSC) product for tumor contamination. 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COG A3973 determined tumor cell contamination of PBSC by immunocytologic","text_display":" determinate of outcome. 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The assigned COG patient identification number will be used to identify the patient in all","text_display":" been obtained. The assigned COG patient identification number will be used to identify the patient in all","confidence":1,"confidence_rate":1},{"cnt":[[245,2243],[1880,2243],[1880,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2242,"width":1636,"height":47},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"208d0b3fc3174032a9025616561c3b97","type":"text","conversion_output":true,"text":"future interactions with the COG. If you have problems with registration, please refer to the online help in","text_display":" future interactions with the COG. If you have problems with registration, please refer to the online help in","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[245,2286],[799,2286],[799,2331],[245,2331]],"region":{"top_left_x":244,"top_left_y":2285,"width":556,"height":47},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cbfe4087156410c8d70b3047bbeb8c3","type":"text","conversion_output":true,"text":"the eRDE area of the COG website.","text_display":" the eRDE area of the COG website.","confidence":1,"confidence_rate":1},{"cnt":[[245,2374],[1880,2374],[1880,2421],[245,2421]],"region":{"top_left_x":244,"top_left_y":2374,"width":1636,"height":48},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a98157b7516b4ffb825004621df01cd6","type":"text","conversion_output":true,"text":"In order for an institution to maintain COG membership requirements, every newly diagnosed patient needs","text_display":"\n\nIn order for an institution to maintain COG membership requirements, every newly diagnosed patient needs","confidence":1,"confidence_rate":1},{"cnt":[[245,2419],[1880,2419],[1880,2464],[245,2464]],"region":{"top_left_x":244,"top_left_y":2419,"width":1636,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13f3c64b42ac4c05a5017f90aeb40c63","type":"text","conversion_output":true,"text":"to be offered participation in ACCRN07, Protocol for the Enrollment on the Official COG Registry, The","text_display":" to be offered participation in ACCRN07, Protocol for the Enrollment on the Official COG Registry, The","confidence":1,"confidence_rate":1},{"cnt":[[245,2462],[952,2462],[952,2507],[245,2507]],"region":{"top_left_x":244,"top_left_y":2462,"width":708,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f737dbbeb79c4d899697f9e05ffb3887","type":"text","conversion_output":true,"text":"Childhood Cancer Research Network (CCRN).","text_display":" Childhood Cancer Research Network (CCRN).","confidence":0.99951171875,"confidence_rate":0.9999893826542317},{"cnt":[[1749,2608],[1880,2608],[1880,2653],[1749,2653]],"region":{"top_left_x":1748,"top_left_y":2608,"width":132,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e66ddb7c4c341e19fade2cb905696cd","type":"page_info","conversion_output":false,"text":"Page 30","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-031","page":31,"lines":[{"cnt":[[245,99],[614,99],[614,165],[245,165]],"region":{"top_left_x":244,"top_left_y":98,"width":371,"height":68},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"096d8480445b419b9ff82816931a2f1c","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,103],[1652,103],[1652,140],[653,140]],"region":{"top_left_x":653,"top_left_y":103,"width":1000,"height":37},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c8f29861d8ec4d4f8afd2c1acdb1422b","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.6495842508738455,"confidence_rate":0.9946217307722369},{"cnt":[[1706,99],[1880,99],[1880,140],[1706,140]],"region":{"top_left_x":1705,"top_left_y":98,"width":175,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecc61ced3d274152bc3debb262245a41","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[329,172],[655,172],[655,208],[329,208]],"region":{"top_left_x":328,"top_left_y":171,"width":328,"height":38},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ac4e8f7df720401ab1ae58c53f88a4bd","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,228],[1880,228],[1880,273],[245,273]],"region":{"top_left_x":244,"top_left_y":227,"width":1636,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d6b480523244f1db3ea5775adb1a437","type":"text","conversion_output":true,"text":"A Biopathology Center (BPC) number will be assigned as part of the registration process. Each patient will","text_display":"\n\nA Biopathology Center (BPC) number will be assigned as part of the registration process. Each patient will","confidence":1,"confidence_rate":1},{"cnt":[[245,271],[1880,271],[1880,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abd4533ab0334194a85c0f450ce5ff7c","type":"text","conversion_output":true,"text":"be assigned only one BPC number per COG Patient ID. Each patient will be assigned only one PBC number","text_display":" be assigned only one BPC number per COG Patient ID. Each patient will be assigned only one PBC number","confidence":1,"confidence_rate":1},{"cnt":[[245,316],[1880,316],[1880,363],[245,363]],"region":{"top_left_x":244,"top_left_y":315,"width":1636,"height":49},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f11e597c718404ba948e73151b2efe7","type":"text","conversion_output":true,"text":"per COG Patient ID. For additional information about the labeling of specimens, please refer to the","text_display":" per COG Patient ID. For additional information about the labeling of specimens, please refer to the","confidence":1,"confidence_rate":1},{"cnt":[[245,361],[1033,361],[1033,406],[245,406]],"region":{"top_left_x":244,"top_left_y":360,"width":790,"height":47},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2984bcd23eba437f9a0925f776b6d0cc","type":"text","conversion_output":true,"text":"pathology and/or Biology guidelines in this protocol.","text_display":" pathology and/or Biology guidelines in this protocol.","confidence":1,"confidence_rate":1},{"cnt":[[241,443],[1010,443],[1010,496],[241,496]],"region":{"top_left_x":240,"top_left_y":442,"width":770,"height":55},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f45e4d3794fc40fbaee7b9b398b92ce1","type":"section_header","conversion_output":false,"children_ids":["2464c15577d349dcb7ca5b87f11d1930"],"text":"","text_display":""},{"cnt":[[245,447],[1008,447],[1008,492],[245,492]],"region":{"top_left_x":244,"top_left_y":446,"width":764,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2464c15577d349dcb7ca5b87f11d1930","type":"text","conversion_output":true,"parent_id":"f45e4d3794fc40fbaee7b9b398b92ce1","text":"3.1.3 Enrollment on Biology Study ANBL00B1","text_display":"\n\n\\subsection*{3.1.3 Enrollment on Biology Study ANBL00B1}","confidence":1,"confidence_rate":1},{"cnt":[[245,490],[1880,490],[1880,535],[245,535]],"region":{"top_left_x":244,"top_left_y":489,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a17911b1168b4fbab101c4fd02aeddad","type":"text","conversion_output":true,"text":"Enrollment on ANBL00B1 is required for all newly diagnosed patients within 21 days of diagnosis. Tissue","text_display":"\n\nEnrollment on ANBL00B1 is required for all newly diagnosed patients within 21 days of diagnosis. Tissue","confidence":1,"confidence_rate":1},{"cnt":[[245,535],[1880,535],[1880,580],[245,580]],"region":{"top_left_x":244,"top_left_y":534,"width":1636,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46e75fb632f8429da73a182c5bf36894","type":"text","conversion_output":true,"text":"procurement is mandatory for biology study registration. For patients with stage 4S disease who are very ill","text_display":" procurement is mandatory for biology study registration. For patients with stage 4S disease who are very ill","confidence":0.71533203125,"confidence_rate":0.9970397136353787},{"cnt":[[245,580],[1880,580],[1880,625],[245,625]],"region":{"top_left_x":244,"top_left_y":580,"width":1636,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b44ed13c42e48dca060582fc08d2bac","type":"text","conversion_output":true,"text":"and in whom an open biopsy to obtain tissue for diagnosis and biologic studies is considered medically","text_display":" and in whom an open biopsy to obtain tissue for diagnosis and biologic studies is considered medically","confidence":1,"confidence_rate":1},{"cnt":[[245,623],[1880,623],[1880,668],[245,668]],"region":{"top_left_x":244,"top_left_y":623,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5d7073802f44f1bb3c92e264771b0c0","type":"text","conversion_output":true,"text":"contraindicated, every effort should be made to obtain some tumor tissue by either fine needle aspiration of a","text_display":" contraindicated, every effort should be made to obtain some tumor tissue by either fine needle aspiration of a","confidence":1,"confidence_rate":1},{"cnt":[[245,666],[1880,666],[1880,711],[245,711]],"region":{"top_left_x":244,"top_left_y":666,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5394c4611cd04b05b7bbbdfeb7873812","type":"text","conversion_output":true,"text":"metastatic site of disease and/or sampling of involved bone marrow, so that this tumor sample can be","text_display":" metastatic site of disease and/or sampling of involved bone marrow, so that this tumor sample can be","confidence":1,"confidence_rate":1},{"cnt":[[245,711],[1880,709],[1880,753],[245,755]],"region":{"top_left_x":244,"top_left_y":708,"width":1636,"height":48},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4142386d6af49768179364c3b080af8","type":"text","conversion_output":true,"text":"submitted for MYCN determination. 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Needle biopsies are not sufficient for histologic","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[1880,799],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46b56fd5319d439cb3d58289f888251c","type":"text","conversion_output":true,"text":"classification. Investigators are strongly encouraged to obtain adequate tissue (see Sections 13.0, 14.0, and","text_display":" classification. Investigators are strongly encouraged to obtain adequate tissue (see Sections 13.0, 14.0, and","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[1880,842],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":842,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7e7815c04a643708ef243aadd131f8e","type":"text","conversion_output":true,"text":"15.0) via open biopsy techniques. For patients with Stage 4 disease who are \\(\\geq 547\\) days of age with","text_display":" 15.0) via open biopsy techniques. 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(See ANBL00B1 protocol for specifics)","text_display":" requirements of ANBL00B1 to be eligible for this study. (See ANBL00B1 protocol for specifics)","confidence":1,"confidence_rate":1},{"cnt":[[241,1053],[892,1053],[892,1106],[241,1106]],"region":{"top_left_x":240,"top_left_y":1052,"width":652,"height":55},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1092c0d25a194bf68b8ac0893058ee5a","type":"section_header","conversion_output":false,"children_ids":["9dea5879179e4cbba3f69132deeafada"],"text":"","text_display":""},{"cnt":[[245,1057],[887,1057],[887,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1057,"width":644,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9dea5879179e4cbba3f69132deeafada","type":"text","conversion_output":true,"parent_id":"1092c0d25a194bf68b8ac0893058ee5a","text":"3.1.4 Study Enrollment on ANBL0532","text_display":"\n\n\\subsection*{3.1.4 Study Enrollment on ANBL0532}","confidence":1,"confidence_rate":1},{"cnt":[[245,1100],[1880,1100],[1880,1147],[245,1147]],"region":{"top_left_x":244,"top_left_y":1100,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c140267bcb334a84a3a9afa90f395e32","type":"text","conversion_output":true,"text":"Patients may be enrolled on the study once all eligibility requirements for the study have been met. Study","text_display":"\n\nPatients may be enrolled on the study once all eligibility requirements for the study have been met. Study","confidence":1,"confidence_rate":1},{"cnt":[[245,1145],[1880,1145],[1880,1192],[245,1192]],"region":{"top_left_x":244,"top_left_y":1145,"width":1636,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3491c931a0042a883017f12c1c8482c","type":"text","conversion_output":true,"text":"enrollment is accomplished by going to the Enrollment application in the eRDE system. If you have","text_display":" enrollment is accomplished by going to the Enrollment application in the eRDE system. 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In emergency","text_display":"\n\nPatients must be enrolled on ANBL00B1 prior to the time of enrollment on ANBL0532. In emergency","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1362],[1880,1362],[1880,1407],[245,1407]],"region":{"top_left_x":244,"top_left_y":1362,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af9aedb015f445c49e5b29e16efca760","type":"text","conversion_output":true,"text":"situations (or if in the opinion of the treating physician, it is in the patient's best interest) consent can be","text_display":" situations (or if in the opinion of the treating physician, it is in the patient's best interest) consent can be","confidence":0.998046875,"confidence_rate":0.9999832904401549},{"cnt":[[245,1405],[1880,1405],[1880,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3158d3f30c7645a798add9e6a89ad8d7","type":"text","conversion_output":true,"text":"obtained and patient enrolled on ANBL00B1 and subsequently enrolled on ANBL0532 as soon as the","text_display":" obtained and patient enrolled on ANBL00B1 and subsequently enrolled on ANBL0532 as soon as the","confidence":1,"confidence_rate":1},{"cnt":[[245,1448],[1880,1448],[1880,1495],[245,1495]],"region":{"top_left_x":244,"top_left_y":1448,"width":1636,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b5bb9589b974598ac171af2c1122d6c","type":"text","conversion_output":true,"text":"assignment of \"High-Risk\" has been made in the eRDE system. When ANBL0532 enrollment is done","text_display":" assignment of \"High-Risk\" has been made in the eRDE system. 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Patients will be","text_display":"\n\nRandomization will take place at completion of Induction phase of therapy via RDE. Patients will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1880,2105],[1880,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2105,"width":1636,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"637c63b29bd948c2b33092acf42bf959","type":"text","conversion_output":true,"text":"assigned to either single myeloablative therapy or tandem myeloablative therapy. Randomization will be","text_display":" assigned to either single myeloablative therapy or tandem myeloablative therapy. Randomization will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2148],[1738,2148],[1738,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2148,"width":1495,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0054538ae61e49e6b84fad72171ec290","type":"text","conversion_output":true,"text":"stratified by initial stage of disease, biologic characteristics and response to induction chemotherapy.","text_display":" stratified by initial stage of disease, biologic characteristics and response to induction 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ploidy and","text_display":" unfavorable histopathology or diploid DNA content or with indeterminant histology or ploidy and","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1878,2368],[1878,2413],[245,2413]],"region":{"top_left_x":244,"top_left_y":2367,"width":1634,"height":46},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"555453426e6543bb816acdf20eadc958","type":"text","conversion_output":true,"text":"patients who are greater than 547 days of age with Stage 3, MYCN nonamplified tumor AND","text_display":" patients who are greater than 547 days of age with Stage 3, MYCN nonamplified tumor 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All clinical and laboratory data required for determining","text_display":" (per COG policy posted \\(5 / 1 1 / 0 1\\) ). 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Patients with the following disease stages at diagnosis are eligible, if they meet","text_display":" catecholamine metabolites. Patients with the following disease stages at diagnosis are eligible, if they meet","confidence":1,"confidence_rate":1},{"cnt":[[245,793],[937,793],[937,840],[245,840]],"region":{"top_left_x":244,"top_left_y":792,"width":693,"height":49},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b175fd073271438ca5ae1fa5626b9665","type":"text","conversion_output":true,"text":"the other specified criteria. See Appendix VII.","text_display":" the other specified criteria. See Appendix VII.","confidence":1,"confidence_rate":1},{"cnt":[[236,872],[359,872],[359,926],[236,926]],"region":{"top_left_x":236,"top_left_y":872,"width":123,"height":54},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66d5e04a77704f369a17386825452015","type":"section_header","conversion_output":false,"children_ids":["a60ec430f17546128ddf1ecd143915b3"],"text":"","text_display":""},{"cnt":[[245,877],[354,877],[354,922],[245,922]],"region":{"top_left_x":244,"top_left_y":876,"width":111,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a60ec430f17546128ddf1ecd143915b3","type":"text","conversion_output":true,"parent_id":"66d5e04a77704f369a17386825452015","text":"3.2.2.1","text_display":"\n\n\\subsection*{3.2.2.1}","confidence":1,"confidence_rate":1},{"cnt":[[245,920],[1729,920],[1729,969],[245,969]],"region":{"top_left_x":244,"top_left_y":919,"width":1486,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e186f55481b44bd08cd9c642cd0486fd","type":"text","conversion_output":true,"text":"Patients with newly diagnosed neuroblastoma with INSS Stage 4 are eligible with the following:","text_display":"\n\nPatients with newly diagnosed neuroblastoma with INSS Stage 4 are eligible with the following:","confidence":1,"confidence_rate":1},{"cnt":[[367,984],[1785,984],[1785,1033],[367,1033]],"region":{"top_left_x":367,"top_left_y":983,"width":1419,"height":51},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93f30bdc8a2c45508797450015e45ef1","type":"text","conversion_output":true,"text":"a. \\(\\quad M Y C N\\) amplification (greater than four-fold increase in \\(M Y C N\\) signals as compared to","text_display":"\na. \\(\\quad M Y C N\\) amplification (greater than four-fold increase in \\(M Y C N\\) signals as compared to","confidence":0.9975600242614746,"confidence_rate":0.999974815190026},{"cnt":[[460,1027],[1497,1027],[1497,1076],[460,1076]],"region":{"top_left_x":459,"top_left_y":1026,"width":1039,"height":51},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"236da5b956514204b9258f05ceba9242","type":"text","conversion_output":true,"text":"reference signals), regardless of age or additional biologic features.","text_display":" reference signals), regardless of age or additional biologic features.","confidence":1,"confidence_rate":1},{"cnt":[[370,1070],[1412,1070],[1412,1119],[370,1119]],"region":{"top_left_x":369,"top_left_y":1069,"width":1043,"height":51},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4826cccec8e4479977b50eae0132272","type":"text","conversion_output":true,"text":"b. Age > 18 months (>547 days) regardless of biologic features.","text_display":"\nb. Age > 18 months (>547 days) regardless of biologic features.","confidence":0.7490234375,"confidence_rate":0.9959380607560621},{"cnt":[[370,1117],[1880,1117],[1880,1164],[370,1164]],"region":{"top_left_x":369,"top_left_y":1117,"width":1511,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"399369d729bc46a2923ea67d1853dd9e","type":"text","conversion_output":true,"text":"c. Age 12-18 months (365-547 days) with any of the following three unfavorable biologic","text_display":"\nc. Age 12-18 months (365-547 days) with any of the following three unfavorable biologic","confidence":0.9748055566774383,"confidence_rate":0.9997226769728624},{"cnt":[[460,1160],[1880,1160],[1880,1210],[460,1210]],"region":{"top_left_x":459,"top_left_y":1160,"width":1421,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e27ef9c8ce2640bea666086ef1d37362","type":"text","conversion_output":true,"text":"features (MYCN amplification, unfavorable pathology and/or DNA index = 1) or any","text_display":" features (MYCN amplification, unfavorable pathology and/or DNA index = 1) or any","confidence":0.6692030896665528,"confidence_rate":0.9952856453498681},{"cnt":[[460,1203],[1424,1203],[1424,1253],[460,1253]],"region":{"top_left_x":459,"top_left_y":1203,"width":966,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39d518cc56bf4c3183f4a043cf4d9df0","type":"text","conversion_output":true,"text":"biologic feature that is indeterminant/unsatisfactory/unknown.","text_display":" biologic feature that is indeterminant/unsatisfactory/unknown.","confidence":1,"confidence_rate":1},{"cnt":[[236,1285],[367,1285],[367,1343],[236,1343]],"region":{"top_left_x":236,"top_left_y":1284,"width":132,"height":59},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd4c07ce1b904c5eb46baca5a78e6256","type":"section_header","conversion_output":false,"children_ids":["33aac64306434a9ea69f51b963190f1d"],"text":"","text_display":""},{"cnt":[[245,1291],[363,1291],[363,1334],[245,1334]],"region":{"top_left_x":244,"top_left_y":1291,"width":120,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33aac64306434a9ea69f51b963190f1d","type":"text","conversion_output":true,"parent_id":"fd4c07ce1b904c5eb46baca5a78e6256","text":"3.2.2.2","text_display":"\n\n\\subsection*{3.2.2.2}","confidence":1,"confidence_rate":1},{"cnt":[[245,1334],[1729,1334],[1729,1384],[245,1384]],"region":{"top_left_x":244,"top_left_y":1334,"width":1486,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"761da23b7f46433e9953d4db18298f37","type":"text","conversion_output":true,"text":"Patients with newly diagnosed neuroblastoma with INSS Stage 3 are eligible with the following:","text_display":"\n\nPatients with newly diagnosed neuroblastoma with INSS Stage 3 are eligible with the following:","confidence":1,"confidence_rate":1},{"cnt":[[370,1379],[1785,1379],[1785,1429],[370,1429]],"region":{"top_left_x":369,"top_left_y":1379,"width":1417,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8f5e644d9c947b6a10a41b5865b0f43","type":"text","conversion_output":true,"text":"a. \\(\\quad M Y C N\\) amplification (greater than four-fold increase in \\(M Y C N\\) signals as compared to","text_display":"\na. \\(\\quad M Y C N\\) amplification (greater than four-fold increase in \\(M Y C N\\) signals as compared to","confidence":0.9980475902557373,"confidence_rate":0.9999798525928524},{"cnt":[[460,1422],[1489,1422],[1489,1472],[460,1472]],"region":{"top_left_x":459,"top_left_y":1422,"width":1030,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c679c649d6124ffdb3f4e892caa396db","type":"text","conversion_output":true,"text":"reference signals), regardless of age or additional biologic features","text_display":" reference signals), regardless of age or additional biologic features","confidence":1,"confidence_rate":1},{"cnt":[[370,1465],[1807,1465],[1807,1515],[370,1515]],"region":{"top_left_x":369,"top_left_y":1465,"width":1438,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16a5eae8e6b5456792dc077ed464262f","type":"text","conversion_output":true,"text":"b. Age > 18 months (> 547 days) with unfavorable pathology, regardless of \\(M Y C N\\) status.","text_display":"\nb. Age > 18 months (> 547 days) with unfavorable pathology, regardless of \\(M Y C N\\) status.","confidence":0.5736279487609863,"confidence_rate":0.9944576730226286},{"cnt":[[236,1543],[367,1543],[367,1601],[236,1601]],"region":{"top_left_x":236,"top_left_y":1542,"width":132,"height":59},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20d698fe41894765a7f1d129614ee987","type":"section_header","conversion_output":false,"children_ids":["e358acdbe3d245d1a08823ef2eb8ee91"],"text":"","text_display":""},{"cnt":[[245,1551],[359,1551],[359,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1551,"width":115,"height":41},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e358acdbe3d245d1a08823ef2eb8ee91","type":"text","conversion_output":true,"parent_id":"20d698fe41894765a7f1d129614ee987","text":"3.2.2.3","text_display":"\n\n\\subsection*{3.2.2.3}","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1880,1594],[1880,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1594,"width":1636,"height":50},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7db7057b9e61467889eaa26f7725c85b","type":"text","conversion_output":true,"text":"Patients with newly diagnosed INSS Stage 2a/2b with \\(M Y C N\\) amplification (greater than four-fold","text_display":"\n\nPatients with newly diagnosed INSS Stage 2a/2b with \\(M Y C N\\) amplification (greater than four-fold","confidence":0.8714263997771923,"confidence_rate":0.9986516562065858},{"cnt":[[245,1641],[1880,1641],[1880,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1641,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ce3c61699ef41809d0046f01c65f967","type":"text","conversion_output":true,"text":"increase in \\(M Y C N\\) signals as compared to reference signals), regardless of age or additional biologic","text_display":" increase in \\(M Y C N\\) signals as compared to reference signals), regardless of age or additional biologic","confidence":0.8701171875,"confidence_rate":0.9987126129304903},{"cnt":[[245,1684],[385,1684],[385,1727],[245,1727]],"region":{"top_left_x":244,"top_left_y":1684,"width":141,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2eb3bd9e71a447d3b980f801dc8be1fb","type":"text","conversion_output":true,"text":"features.","text_display":" features.","confidence":1,"confidence_rate":1},{"cnt":[[236,1762],[367,1762],[367,1815],[236,1815]],"region":{"top_left_x":236,"top_left_y":1761,"width":132,"height":55},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71fc5a73fc11414da5f5a76f4ec96b8c","type":"section_header","conversion_output":false,"children_ids":["1abb22cb84804ac289a24c3b0b68a2ab"],"text":"","text_display":""},{"cnt":[[245,1766],[363,1766],[363,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1766,"width":120,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1abb22cb84804ac289a24c3b0b68a2ab","type":"text","conversion_output":true,"parent_id":"71fc5a73fc11414da5f5a76f4ec96b8c","text":"3.2.2.4","text_display":"\n\n\\subsection*{3.2.2.4}","confidence":1,"confidence_rate":1},{"cnt":[[245,1809],[1841,1809],[1841,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1808,"width":1598,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"605cb5efecd44b6cb07f264027414cbe","type":"text","conversion_output":true,"text":"Patients with newly diagnosed INSS Stage 4s with MYCN amplification (greater than four-fold increase","text_display":"\n\nPatients with newly diagnosed INSS Stage 4s with MYCN amplification (greater than four-fold increase","confidence":0.5424385070800781,"confidence_rate":0.9941914064352599},{"cnt":[[245,1856],[1687,1856],[1687,1904],[245,1904]],"region":{"top_left_x":244,"top_left_y":1856,"width":1443,"height":48},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73c84fbb72ff40bbb3211ba0f9fed9a4","type":"text","conversion_output":true,"text":"in \\(M Y C N\\) signals as compared to reference signals), regardless of additional biologic features.","text_display":" in \\(M Y C N\\) signals as compared to reference signals), regardless of additional biologic features.","confidence":0.99560546875,"confidence_rate":0.9999568223480155},{"cnt":[[236,1938],[367,1938],[367,1992],[236,1992]],"region":{"top_left_x":236,"top_left_y":1937,"width":132,"height":55},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38586c0871d3428d9520593de974ddee","type":"section_header","conversion_output":false,"children_ids":["9109816a3a5845a28f5b4d66b94ffeeb"],"text":"","text_display":""},{"cnt":[[245,1942],[359,1942],[359,1985],[245,1985]],"region":{"top_left_x":244,"top_left_y":1942,"width":115,"height":44},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9109816a3a5845a28f5b4d66b94ffeeb","type":"text","conversion_output":true,"parent_id":"38586c0871d3428d9520593de974ddee","text":"3.2.2.5","text_display":"\n\n\\subsection*{3.2.2.5}","confidence":1,"confidence_rate":1},{"cnt":[[245,1989],[1880,1989],[1880,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1989,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80adca7fce974cfe9c0185ec5a63e9c9","type":"text","conversion_output":true,"text":"Patients \\(\\geq 365\\) days initially diagnosed with: INSS stage \\(1,2,4 S\\) who progressed to a stage 4 without","text_display":"\n\nPatients \\(\\geq 365\\) days initially diagnosed with: INSS stage \\(1,2,4 S\\) who progressed to a stage 4 without","confidence":0.9824597691185772,"confidence_rate":0.9998461345903304},{"cnt":[[245,2032],[1880,2032],[1880,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2032,"width":1636,"height":50},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48138c04da8342a9a29d2e1ab27c5ab2","type":"text","conversion_output":true,"text":"interval chemotherapy. These patients must have been enrolled on ANBL00B1. It is to be noted that","text_display":" interval chemotherapy. These patients must have been enrolled on ANBL00B1. It is to be noted that","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1697,2075],[1697,2125],[245,2125]],"region":{"top_left_x":244,"top_left_y":2075,"width":1454,"height":50},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4abd5e217147482eb4a229d660a4e041","type":"text","conversion_output":true,"text":"study enrollment must occur within 4 weeks of progression to Stage 4 for INSS Stage 1, 2, 4S.","text_display":" study enrollment must occur within 4 weeks of progression to Stage 4 for INSS Stage 1, 2, 4S.","confidence":0.99853515625,"confidence_rate":0.9999859047370074},{"cnt":[[236,2144],[595,2144],[595,2206],[236,2206]],"region":{"top_left_x":236,"top_left_y":2144,"width":360,"height":63},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69f7a1b8c46c454c93429d5490e71c37","type":"section_header","conversion_output":false,"children_ids":["a4d841f43a094120857696c9090cff5a"],"text":"","text_display":""},{"cnt":[[245,2153],[587,2153],[587,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2152,"width":343,"height":51},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4d841f43a094120857696c9090cff5a","type":"text","conversion_output":true,"parent_id":"69f7a1b8c46c454c93429d5490e71c37","text":"3.2.3 Prior Therapy","text_display":"\n\n\\subsection*{3.2.3 Prior 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Primary site tumor assessment prior to surgical resection (Cycle 5 or Cycle 6, if","text_display":" chemotherapy. Primary site tumor assessment prior to surgical resection (Cycle 5 or Cycle 6, if","confidence":0.986328125,"confidence_rate":0.9998663565450225},{"cnt":[[245,799],[1880,799],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51bb559da0d9437a8fd91c36224a7f23","type":"text","conversion_output":true,"text":"medically necessary) is mandatory as the pre-surgical primary tumor volume will be used to","text_display":" medically necessary) is mandatory as the pre-surgical primary tumor volume will be used to","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[664,842],[664,883],[245,883]],"region":{"top_left_x":244,"top_left_y":842,"width":420,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51d55fbce6fc400dad98e820fc53b273","type":"text","conversion_output":true,"text":"establish radiation fields.","text_display":" establish radiation fields.","confidence":1,"confidence_rate":1},{"cnt":[[241,924],[363,924],[363,973],[241,973]],"region":{"top_left_x":240,"top_left_y":923,"width":124,"height":51},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22fe59de7681459aacee86349ad9acac","type":"section_header","conversion_output":false,"children_ids":["43152669f4e24f4d802db6d1734ca996"],"text":"","text_display":""},{"cnt":[[245,928],[359,928],[359,969],[245,969]],"region":{"top_left_x":244,"top_left_y":928,"width":115,"height":41},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43152669f4e24f4d802db6d1734ca996","type":"text","conversion_output":true,"parent_id":"22fe59de7681459aacee86349ad9acac","text":"4.1.3.3","text_display":"\n\n\\subsection*{4.1.3.3}","confidence":1,"confidence_rate":1},{"cnt":[[245,975],[1848,975],[1848,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":975,"width":1604,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"354ba9ea9ec1451a968bd88362e07a25","type":"text","conversion_output":true,"text":"Patients with progressive disease (PD) at the end of induction evaluation will be taken off protocol","text_display":"\n\nPatients with progressive disease (PD) at the end of induction evaluation will be taken off protocol","confidence":1,"confidence_rate":1},{"cnt":[[245,1018],[389,1018],[389,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1018,"width":145,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47b8f9ce707b4710b51610e6e369009b","type":"text","conversion_output":true,"text":"therapy.","text_display":" therapy.","confidence":1,"confidence_rate":1},{"cnt":[[243,1104],[1661,1104],[1661,1154],[243,1154]],"region":{"top_left_x":242,"top_left_y":1104,"width":1419,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5f856afb9c349b09e1cd7dc20e7d9df","type":"text","conversion_output":true,"text":"4.1.3.4 Peripheral Blood Stem Cell Harvest (PBSC) (See Section 19.0 for complete details)","text_display":"\n4.1.3.4 Peripheral Blood Stem Cell Harvest (PBSC) (See Section 19.0 for complete details)","confidence":1,"confidence_rate":1},{"cnt":[[243,1147],[1880,1147],[1880,1197],[243,1197]],"region":{"top_left_x":242,"top_left_y":1147,"width":1638,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df6ccce8451641cba776346459868151","type":"text","conversion_output":true,"text":"Patients will undergo PBSC harvest after 2 cycles REGARDLESS of persistent bone marrow metastatic","text_display":"\n\nPatients will undergo PBSC harvest after 2 cycles REGARDLESS of persistent bone marrow metastatic","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1880,1195],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1194,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"524fb9f8d4654c92b6ba984d35c6cc42","type":"text","conversion_output":true,"text":"disease. There will not be any no ex vivo manipulation of PBSC prior to cryopreservation as results from","text_display":" disease. There will not be any no ex vivo manipulation of PBSC prior to cryopreservation as results from","confidence":1,"confidence_rate":1},{"cnt":[[245,1238],[1884,1238],[1884,1285],[245,1285]],"region":{"top_left_x":244,"top_left_y":1237,"width":1641,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71899e53459e4b86a6d1afbe82b53433","type":"text","conversion_output":true,"text":"the randomized question in A3973 did not demonstrate a benefit in survival following ex vivo purging of","text_display":" the randomized question in A3973 did not demonstrate a benefit in survival following ex vivo purging of","confidence":1,"confidence_rate":1},{"cnt":[[245,1280],[483,1280],[483,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1280,"width":240,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6481db246bcd4dffbc4b76908be09504","type":"text","conversion_output":true,"text":"PBSC product.","text_display":" PBSC product.","confidence":1,"confidence_rate":1},{"cnt":[[254,1369],[1880,1369],[1880,1416],[254,1416]],"region":{"top_left_x":253,"top_left_y":1368,"width":1627,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29b87c7ee7124a5db4a9ebddb2017887","type":"text","conversion_output":true,"text":"PBSC collection will be performed prior to randomization. Therefore, all patients must have a PBSC","text_display":"\n\nPBSC collection will be performed prior to randomization. Therefore, all patients must have a PBSC","confidence":1,"confidence_rate":1},{"cnt":[[245,1409],[1880,1409],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1409,"width":1636,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5299375f5c7464cb9fc3198c784166f","type":"text","conversion_output":true,"text":"collection that is sufficient for tandem transplant with a goal for collection of \\(10 \\times 10^{6} CD 34+ cells / kg\\)","text_display":" collection that is sufficient for tandem transplant with a goal for collection of \\(10 \\times 10^{6} CD 34+ cells / kg\\)","confidence":0.9517943317769095,"confidence_rate":0.9995917667748282},{"cnt":[[245,1452],[1880,1452],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1452,"width":1636,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e6eca05d43e4ea8b49ac75ecebc60f0","type":"text","conversion_output":true,"text":"divided into 3 separate aliquots. A minimum number of frozen PBSC of \\(4 \\times 10^{6}\\) CD34 cells \\(/ kg\\) divided","text_display":" divided into 3 separate aliquots. A minimum number of frozen PBSC of \\(4 \\times 10^{6}\\) CD34 cells \\(/ kg\\) divided","confidence":0.9912254726530136,"confidence_rate":0.9999271658740632},{"cnt":[[245,1497],[1880,1497],[1880,1545],[245,1545]],"region":{"top_left_x":244,"top_left_y":1497,"width":1636,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15661b25adeb488d9de2b8ceb73ce8c1","type":"text","conversion_output":true,"text":"into 2 aliquots is required for all patients ( \\(2 \\times 10^{6}\\) CD34 cells \\(/ kg\\) for each transplant) to remain eligible for","text_display":" into 2 aliquots is required for all patients ( \\(2 \\times 10^{6}\\) CD34 cells \\(/ kg\\) for each transplant) to remain eligible 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doses for all drugs EXCEPT topotecan will be dosed per","text_display":"\n- For patients \\(\\leq 12 kg\\), chemotherapy doses for all drugs EXCEPT topotecan will be dosed per","confidence":0.9985356330871582,"confidence_rate":0.9999854907968839},{"cnt":[[400,1826],[793,1826],[793,1871],[400,1871]],"region":{"top_left_x":399,"top_left_y":1826,"width":394,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10bd023b7d5b4e888a135cd8d3fffbba","type":"text","conversion_output":true,"text":"kg rather than per BSA.","text_display":" kg rather than per BSA.","confidence":0.96484375,"confidence_rate":0.9987226341039553},{"cnt":[[305,1873],[1474,1873],[1474,1919],[305,1919]],"region":{"top_left_x":305,"top_left_y":1873,"width":1169,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f981e138a3a46bba5837dd4da5a85e9","type":"text","conversion_output":true,"text":"- Topotecan dosing will be based on BSA regardless of age or weight.","text_display":"\n- Topotecan dosing will be based on BSA regardless of age or weight.","confidence":0.9970703125,"confidence_rate":0.9999598091989762},{"cnt":[[305,1921],[1708,1921],[1708,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1920,"width":1404,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81cdbbd8b4824f94a8c1d2daa2a109a7","type":"text","conversion_output":true,"text":"- Note specific dosing instructions for vinCRIStine in Cycles 4 and 6 of induction.","text_display":"\n- Note specific dosing instructions for vinCRIStine in Cycles 4 and 6 of 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planned), cytokine support need not be limited to G-CSF i.e: other","text_display":" cycles in which PBSC collections are planned), cytokine support need not be limited to G-CSF i.e: other","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1880,2093],[1880,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2092,"width":1636,"height":50},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2297a25873e41d1b29db7f2b9e5f8cb","type":"text","conversion_output":true,"text":"growth factors are permitted according to an institution's standard guidelines. Choice of myeloid growth","text_display":" growth factors are permitted according to an institution's standard guidelines. Choice of myeloid growth","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1880,2140],[1880,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2139,"width":1636,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20fa6c45b6db45ba9a91f0c0ae7582ab","type":"text","conversion_output":true,"text":"factor must be recorded appropriately in the therapy delivery maps. Myeloid growth factors (including G-","text_display":" factor must be recorded appropriately in the therapy delivery maps. Myeloid growth factors (including G","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1880,2183],[1880,2228],[245,2228]],"region":{"top_left_x":244,"top_left_y":2182,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fde427047c2464192903e12d9a18d08","type":"text","conversion_output":true,"text":"CSF) should be administered \\(24-48\\) hours after the last dose of chemotherapy. Daily myeloid growth","text_display":"CSF) should be administered \\(24-48\\) hours after the last dose of chemotherapy. Daily myeloid growth","confidence":0.9965846532722935,"confidence_rate":0.9999674177466418},{"cnt":[[245,2226],[1880,2226],[1880,2273],[245,2273]],"region":{"top_left_x":244,"top_left_y":2225,"width":1636,"height":49},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c47ea2c7fcb46e084c6008660f6ca73","type":"text","conversion_output":true,"text":"factor therapy should be continued until the ANC \\(>1500 / \\mu L\\). Discontinue daily myeloid growth factor","text_display":" factor therapy should be continued until the ANC \\(>1500 / \\mu L\\). Discontinue daily myeloid growth factor","confidence":0.93359375,"confidence_rate":0.9993755233163414},{"cnt":[[245,2271],[1880,2271],[1880,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2270,"width":1636,"height":49},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"100649fd57ce4b6e827b2063cf0c93d0","type":"text","conversion_output":true,"text":"support a minimum of 24 hours prior to administration of the next chemotherapy cycle. See Appendix II","text_display":" support a minimum of 24 hours prior to administration of the next chemotherapy cycle. See Appendix II","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[715,2316],[715,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2316,"width":472,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a2956012a7e4c82bf6cf2d61e0375a2","type":"text","conversion_output":true,"text":"for supportive care guidelines.","text_display":" for supportive care guidelines.","confidence":1,"confidence_rate":1},{"cnt":[[245,2398],[1880,2398],[1880,2445],[245,2445]],"region":{"top_left_x":244,"top_left_y":2397,"width":1636,"height":48},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64afb92d2ee74b2b902fd22c30a5e77c","type":"text","conversion_output":true,"text":"Institutions are permitted to use their standard guidelines for hydration/monitoring parameters pertaining","text_display":"\n\nInstitutions are permitted to use their standard guidelines for hydration/monitoring parameters pertaining","confidence":1,"confidence_rate":1},{"cnt":[[245,2443],[1880,2443],[1880,2490],[245,2490]],"region":{"top_left_x":244,"top_left_y":2442,"width":1636,"height":49},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfa7d9d2f2054cb393b51798b503c2be","type":"text","conversion_output":true,"text":"to chemotherapy agents utilized in this protocol. In the absence of institutional standards, suggested","text_display":" to chemotherapy agents utilized in this protocol. 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Suggest achieving urine specific gravity \\(\\leq\\) 1.010 prior to start of CISplatin. Hydration fluids may contain supplemental magnesium, calcium and potassium to decrease electrolyte losses associated with cisplatin. Administration of mannitol per institutional guidelines is recommended. & \\begin{tabular}{l}\na. Physical, Ht, Wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr, Ca, Phos, Mg \\\\\nd. ALT, AST, Bilirubin, Urinalysis \\\\\nRefer to Protocol Section 7.0 for complete list of observations \\\\\nOBTAIN OTHER STUDIES AS REQUIRED FOR GOOD PATIENT CARE\n\\end{tabular} \\\\\n\\hline Etoposide (ETOP) & IV over 1 hour & \\(200 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 6.67 mg / kg /\\) dose ) once daily x 3 doses. & Days 1-3 & & \\\\\n\\hline \\multicolumn{5}{|c|}{Myeloid growth factor Adminsitration: Begin 24 - 48 hours after completion of chemotherapy.If given daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections 4.2 and Appendix II for specific directions.} & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline CISplatin (CDDP) & IV over 1 hour & \\(50 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 1.66 mg / kg /\\) dose \\()\\) once daily x 4 doses. & Days 1-4 & Suggest hydrating at 3000 \\(mL / m ^{2} /\\) day using fluid containing at least 0.45\\% NaCl. Suggest achieving urine specific gravity \\(\\leq\\) 1.010 prior to start of CISplatin. Hydration fluids may contain supplemental magnesium, calcium and potassium to decrease electrolyte losses associated with cisplatin. Administration of mannitol per institutional guidelines is recommended. & \\begin{tabular}{l}\na. Physical, Ht, Wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr, Ca, Phos, Mg \\\\\nd. 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If given daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections Section 4.2 and Appendix II for specific directions.} & 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total of 3 doses.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nNOTE: total dose may not exceed 2 mg in 72 hours or \\(0.67 mg /\\) day for any patient \\\\\nVinCRIStine should be administered prior to start of DOXOrubicin infusion and then daily for a total of 3 doses.\n\\end{tabular}","cell_row":4,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":0.5239613765056674,"confidence_rate":0.9954497103346739},{"cnt":[[1331,1151],[1632,1151],[1632,1183],[1331,1183]],"region":{"top_left_x":1330,"top_left_y":1150,"width":302,"height":34},"line":121,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ecc722d99054e12913bf8ed8d1049d0","type":"text","conversion_output":false,"parent_id":"ab42813a53424911a41987e79f07ec80","text":"NOTE: total dose may","text_display":"NOTE: total dose 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infusion","confidence":1,"confidence_rate":1},{"cnt":[[1331,1437],[1641,1437],[1641,1469],[1331,1469]],"region":{"top_left_x":1330,"top_left_y":1436,"width":311,"height":34},"line":128,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"caf56dc261a84e348ed3b02b57b1025a","type":"text","conversion_output":false,"parent_id":"ab42813a53424911a41987e79f07ec80","text":"and then daily for a total","text_display":" and then daily for a total","confidence":1,"confidence_rate":1},{"cnt":[[1331,1471],[1467,1471],[1467,1499],[1331,1499]],"region":{"top_left_x":1330,"top_left_y":1471,"width":138,"height":29},"line":129,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6a1596feadb488b880a1cecaca14dfd","type":"text","conversion_output":false,"parent_id":"ab42813a53424911a41987e79f07ec80","text":"of 3 doses.","text_display":" of 3 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If given daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections Section 4.2 and Appendix II for specific directions.","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":5},{"cnt":[[107,1506],[1597,1506],[1597,1623],[107,1623]],"region":{"top_left_x":107,"top_left_y":1505,"width":1491,"height":118},"line":131,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b421260953d42a2901a516e0cdaaef6","type":"complex_cell","conversion_output":false,"parent_id":"1580429bdbb644889570af9f977f5d84","children_ids":["8a7419d23a3c4082a4ca47e7cbd94b07","453a339110d74a87aa50731b04285a92","aaad84729f2d4da1a6dbafdc21885779"],"text":"Myeloid growth factor Adminsitration: Begin 24-48 hours after completion of chemotherapy. If given daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections Section 4.2 and Appendix II for specific directions.","text_display":"Myeloid growth factor Adminsitration: Begin 24-48 hours after completion of chemotherapy. If given daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections Section 4.2 and Appendix II for specific directions.","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":5,"confidence":0.5263774394989014,"confidence_rate":0.9978381172103631},{"cnt":[[110,1510],[1593,1510],[1593,1547],[110,1547]],"region":{"top_left_x":109,"top_left_y":1510,"width":1485,"height":37},"line":132,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a7419d23a3c4082a4ca47e7cbd94b07","type":"text","conversion_output":false,"parent_id":"6b421260953d42a2901a516e0cdaaef6","text":"Myeloid growth factor Adminsitration: Begin 24-48 hours after completion of chemotherapy. If given","text_display":"Myeloid growth factor Adminsitration: Begin 24-48 hours after completion of chemotherapy. If given","confidence":0.5263774394989014,"confidence_rate":0.9937889150704382},{"cnt":[[110,1549],[1545,1549],[1545,1590],[110,1590]],"region":{"top_left_x":109,"top_left_y":1549,"width":1437,"height":42},"line":133,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"453a339110d74a87aa50731b04285a92","type":"text","conversion_output":false,"parent_id":"6b421260953d42a2901a516e0cdaaef6","text":"daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections Section 4.2 and Appendix II for specific","text_display":" daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections Section 4.2 and Appendix II for specific","confidence":0.9702953780069947,"confidence_rate":0.9997378192412076},{"cnt":[[110,1590],[259,1590],[259,1621],[110,1621]],"region":{"top_left_x":109,"top_left_y":1590,"width":151,"height":31},"line":134,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aaad84729f2d4da1a6dbafdc21885779","type":"text","conversion_output":false,"parent_id":"6b421260953d42a2901a516e0cdaaef6","text":"directions.","text_display":" 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\\multicolumn{4}{|r|}{Therapy Delivery Map Cycle 4} & \\multicolumn{3}{|c|}{\\begin{tabular}{l}\nHt \\\\\ncm\n\\end{tabular}} & \\multicolumn{2}{|r|}{Wt kg} & BSA & \\multicolumn{2}{|c|}{} \\\\\n\\hline Date Due & Date Given & Day & CPM\n<smiles>C[13CH3]</smiles> & Mesna\n<smiles>C[13CH3]</smiles> & & Doxo\n\\(\\_\\_\\_\\_\\) & VCR\n\\(\\_\\_\\_\\_\\) mg & & \\begin{tabular}{l}\nMyeloid Growth \\\\\nFactor: \\(\\_\\_\\_\\_\\)![](https://cdn.mathpix.com/cropped/7e9a11d0-792e-4d29-97ca-9108a5b06777-039.jpg?height=34\\&width=140\\&top_left_y=1745\\&top_left_x=1316)\n\\end{tabular} & Studies & Comments (Include any held doses, or dose modifications) \\\\\n\\hline & & & \\multicolumn{6}{|l|}{Enter calculated dose above and actual dose administered below} & & a, b, c, d & \\\\\n\\hline & & 1 & CPM mg & Mesna mg & & Doxo_mg & VCR_ mg & & & & \\\\\n\\hline & & & & Mesna_mg & & & & & & & \\\\\n\\hline & & & & Mesna_mg & & & & & & & \\\\\n\\hline & & 2 & CPM mg & Mesna_mg & & Doxo_mg & VCR_ mg & & & & \\\\\n\\hline & & & & Mesna_ mg & & & & & & & \\\\\n\\hline & & & & Mesna_mg & & & & & & & \\\\\n\\hline & & 3 & & & & Doxo_ mg & VCR_ mg & & & & \\\\\n\\hline & & 4 & & & & & & & & & \\\\\n\\hline & & 5 & & & & & & & __ mcg & b (obtain twice weekly while on myeloid growth factor) & Date of last dose:\n\\(\\_\\_\\_\\_\\) \\\\\n\\hline & & 21 & \\multicolumn{7}{|c|}{} & & \\\\\n\\hline & & 22 & \\multicolumn{7}{|l|}{Begin next cycle on day 22} & & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|l|}\n\\hline \\multicolumn{4}{|r|}{Therapy Delivery Map Cycle 4} & \\multicolumn{3}{|c|}{\\begin{tabular}{l}\nHt \\\\\ncm\n\\end{tabular}} & \\multicolumn{2}{|r|}{Wt kg} & BSA & \\multicolumn{2}{|c|}{} \\\\\n\\hline Date Due & Date Given & Day & CPM\n<smiles>C[13CH3]</smiles> & Mesna\n<smiles>C[13CH3]</smiles> & & Doxo\n\\(\\_\\_\\_\\_\\) & VCR\n\\(\\_\\_\\_\\_\\) mg & & \\begin{tabular}{l}\nMyeloid Growth \\\\\nFactor: 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POLICY","text_display":"","confidence":0.9796114569383008,"confidence_rate":0.9997425424173247},{"cnt":[[1708,103],[1876,103],[1876,135],[1708,135]],"region":{"top_left_x":1708,"top_left_y":103,"width":168,"height":33},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb606c851bcd462b846032abaf0d5442","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,266],[793,266],[793,320],[241,320]],"region":{"top_left_x":240,"top_left_y":266,"width":553,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a4e3d5c20724adebdf4d43fe1e3415e","type":"section_header","conversion_output":false,"children_ids":["d477021043544edbad2cbff13bbabe5c"],"text":"","text_display":""},{"cnt":[[245,271],[788,271],[788,316],[245,316]],"region":{"top_left_x":244,"top_left_y":270,"width":545,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d477021043544edbad2cbff13bbabe5c","type":"text","conversion_output":true,"parent_id":"7a4e3d5c20724adebdf4d43fe1e3415e","text":"4.2.5 Induction Therapy Cycle 5","text_display":"\n\n\\subsection*{4.2.5 Induction Therapy Cycle 5}","confidence":1,"confidence_rate":1},{"cnt":[[1375,318],[1489,318],[1489,352],[1375,352]],"region":{"top_left_x":1375,"top_left_y":317,"width":114,"height":36},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"118676f1db364fa6964c744afa20a673","type":"figure_label","conversion_output":false,"text":"COG \\#","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[90,352],[2037,352],[2037,608],[90,608]],"region":{"top_left_x":90,"top_left_y":352,"width":1947,"height":257},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2668b7fc9acf43f6b0b569fd5b831f2d","type":"table","conversion_output":true,"children_ids":["7e702498f9a64b12bc32f607a1defac5","a527dc2bceca496bb3da734d019850dd","54110438204b4c2fb54ef5b8f6e1a697","9b1bb2d977de49cb9157e5f0cbe8f14e","90d2ba6542ef4128b1ad04efb73530a8"],"selected_labels":["118676f1db364fa6964c744afa20a673"],"text":"\\begin{tabular}{|l|l|}\n\\hline \\begin{tabular}{l}\nInduction Therapy Cycle 5 \\\\\nPatients will undergo surgical resection after Cycle 5 (or Cycle 6, if medically necessary). Begin next chemotherapy cycle as soon as possible following surgery. Therapy should not be delayed by more than one week unless complications arise. If surgery cannot be scheduled after Cycle 5, it should occur after Cycle 6.\n\\end{tabular} & \\begin{tabular}{l}\nPatient name or initials \\\\\nDOB\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{COG \\#}\n\\begin{tabular}{|l|l|}\n\\hline \\begin{tabular}{l}\nInduction Therapy Cycle 5 \\\\\nPatients will undergo surgical resection after Cycle 5 (or Cycle 6, if medically necessary). Begin next chemotherapy cycle as soon as possible following surgery. Therapy should not be delayed by more than one week unless complications arise. If surgery cannot be scheduled after Cycle 5, it should occur after Cycle 6.\n\\end{tabular} & \\begin{tabular}{l}\nPatient name or initials \\\\\nDOB\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":1,"confidence_rate":1},{"cnt":[[103,352],[1121,352],[1121,608],[103,608]],"region":{"top_left_x":102,"top_left_y":352,"width":1019,"height":256},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e702498f9a64b12bc32f607a1defac5","type":"table_column","conversion_output":false,"parent_id":"2668b7fc9acf43f6b0b569fd5b831f2d","text":"","text_display":""},{"cnt":[[1316,352],[2035,352],[2035,608],[1316,608]],"region":{"top_left_x":1315,"top_left_y":352,"width":720,"height":256},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a527dc2bceca496bb3da734d019850dd","type":"table_column","conversion_output":false,"parent_id":"2668b7fc9acf43f6b0b569fd5b831f2d","text":"","text_display":""},{"cnt":[[90,356],[2035,356],[2035,608],[90,608]],"region":{"top_left_x":90,"top_left_y":356,"width":1945,"height":252},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54110438204b4c2fb54ef5b8f6e1a697","type":"table_row","conversion_output":false,"parent_id":"2668b7fc9acf43f6b0b569fd5b831f2d","text":"","text_display":""},{"cnt":[[103,361],[1121,361],[1121,608],[103,608]],"region":{"top_left_x":102,"top_left_y":360,"width":1019,"height":248},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b1bb2d977de49cb9157e5f0cbe8f14e","type":"complex_cell","conversion_output":false,"parent_id":"2668b7fc9acf43f6b0b569fd5b831f2d","children_ids":["743010e4338d46c1bbd20b7be40fe7fd","c4724cc7f0cc406a802924d952d380ab","98f4eff20fc5401bb25b3af48a8b4a0e","c99ef415408148d98a161fccdae292c3","f91653c682c34a54878a9565a7946c41","5ddb03af7b2f4f118dddcfd2e7eabb4e"],"text":"\\begin{tabular}{l}\nInduction Therapy Cycle 5 \\\\\nPatients will undergo surgical resection after Cycle 5 (or Cycle 6, if medically necessary). Begin next chemotherapy cycle as soon as possible following surgery. Therapy should not be delayed by more than one week unless complications arise. If surgery cannot be scheduled after Cycle 5, it should occur after Cycle 6.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nInduction Therapy Cycle 5 \\\\\nPatients will undergo surgical resection after Cycle 5 (or Cycle 6, if medically necessary). Begin next chemotherapy cycle as soon as possible following surgery. Therapy should not be delayed by more than one week unless complications arise. If surgery cannot be scheduled after Cycle 5, it should occur after Cycle 6.\n\\end{tabular}","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[107,361],[525,361],[525,406],[107,406]],"region":{"top_left_x":107,"top_left_y":360,"width":419,"height":47},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"743010e4338d46c1bbd20b7be40fe7fd","type":"text","conversion_output":false,"parent_id":"9b1bb2d977de49cb9157e5f0cbe8f14e","text":"Induction Therapy Cycle 5","text_display":"Induction Therapy Cycle 5","confidence":1,"confidence_rate":1},{"cnt":[[107,404],[1114,404],[1114,445],[107,445]],"region":{"top_left_x":107,"top_left_y":403,"width":1008,"height":43},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4724cc7f0cc406a802924d952d380ab","type":"text","conversion_output":false,"parent_id":"9b1bb2d977de49cb9157e5f0cbe8f14e","text":"Patients will undergo surgical resection after Cycle 5 (or Cycle 6, if","text_display":"\nPatients will undergo surgical resection after Cycle 5 (or Cycle 6, if","confidence":1,"confidence_rate":1},{"cnt":[[107,445],[1110,445],[1110,486],[107,486]],"region":{"top_left_x":107,"top_left_y":445,"width":1003,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98f4eff20fc5401bb25b3af48a8b4a0e","type":"text","conversion_output":false,"parent_id":"9b1bb2d977de49cb9157e5f0cbe8f14e","text":"medically necessary). Begin next chemotherapy cycle as soon as","text_display":" medically necessary). Begin next chemotherapy cycle as soon as","confidence":1,"confidence_rate":1},{"cnt":[[107,486],[1110,486],[1110,527],[107,527]],"region":{"top_left_x":107,"top_left_y":486,"width":1003,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c99ef415408148d98a161fccdae292c3","type":"text","conversion_output":false,"parent_id":"9b1bb2d977de49cb9157e5f0cbe8f14e","text":"possible following surgery. Therapy should not be delayed by more","text_display":" possible following surgery. Therapy should not be delayed by more","confidence":1,"confidence_rate":1},{"cnt":[[107,525],[1110,525],[1110,566],[107,566]],"region":{"top_left_x":107,"top_left_y":525,"width":1003,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f91653c682c34a54878a9565a7946c41","type":"text","conversion_output":false,"parent_id":"9b1bb2d977de49cb9157e5f0cbe8f14e","text":"than one week unless complications arise. If surgery cannot be","text_display":" than one week unless complications arise. If surgery cannot be","confidence":1,"confidence_rate":1},{"cnt":[[107,564],[902,564],[902,605],[107,605]],"region":{"top_left_x":107,"top_left_y":564,"width":796,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ddb03af7b2f4f118dddcfd2e7eabb4e","type":"text","conversion_output":false,"parent_id":"9b1bb2d977de49cb9157e5f0cbe8f14e","text":"scheduled after Cycle 5, it should occur after Cycle 6.","text_display":" scheduled after Cycle 5, it should occur after Cycle 6.","confidence":1,"confidence_rate":1},{"cnt":[[1326,432],[1833,432],[1833,573],[1326,573]],"region":{"top_left_x":1326,"top_left_y":432,"width":508,"height":141},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90d2ba6542ef4128b1ad04efb73530a8","type":"complex_cell","conversion_output":false,"parent_id":"2668b7fc9acf43f6b0b569fd5b831f2d","children_ids":["fe6d1ebc5e584cb28edcc372ef8b314c","8c3373a4513d44f385832be689e40b87"],"text":"\\begin{tabular}{l}\nPatient name or initials \\\\\nDOB\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nPatient name or initials \\\\\nDOB\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1472,447],[1801,447],[1801,484],[1472,484]],"region":{"top_left_x":1471,"top_left_y":447,"width":330,"height":38},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe6d1ebc5e584cb28edcc372ef8b314c","type":"text","conversion_output":false,"parent_id":"90d2ba6542ef4128b1ad04efb73530a8","text":"Patient name or initials","text_display":"Patient name or initials","confidence":1,"confidence_rate":1},{"cnt":[[1537,534],[1621,534],[1621,569],[1537,569]],"region":{"top_left_x":1536,"top_left_y":533,"width":86,"height":36},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c3373a4513d44f385832be689e40b87","type":"text","conversion_output":false,"parent_id":"90d2ba6542ef4128b1ad04efb73530a8","text":"DOB","text_display":"\nDOB","confidence":1,"confidence_rate":1},{"cnt":[[90,606],[1957,606],[1957,651],[90,651]],"region":{"top_left_x":90,"top_left_y":605,"width":1868,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0a955f98d984a6a9183ff347a39afa4","type":"text","conversion_output":true,"text":"Patients should begin each cycle of induction therapy on Day 22 of the prior cycle or as soon thereafter as ANC \\(\\geq 750 / \\mu L\\)","text_display":"\n\nPatients should begin each cycle of induction therapy on Day 22 of the prior cycle or as soon thereafter as ANC \\(\\geq 750 / \\mu L\\)","confidence":0.8548315800726414,"confidence_rate":0.9987848411381336},{"cnt":[[90,649],[1575,649],[1575,694],[90,694]],"region":{"top_left_x":90,"top_left_y":648,"width":1485,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7346357b242345f9b349d33ec5e81b20","type":"text","conversion_output":true,"text":"and platelets \\(\\geq 75,000 / \\mu L\\). This course lasts 21 days. This Therapy Delivery Map is on one page.","text_display":" and platelets \\(\\geq 75,000 / \\mu L\\). This course lasts 21 days. This Therapy Delivery Map is on one page.","confidence":1,"confidence_rate":1},{"cnt":[[92,718],[2032,718],[2032,1609],[92,1609]],"region":{"top_left_x":92,"top_left_y":717,"width":1941,"height":893},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9994bf09ff54fa0b371d6fe93170da6","type":"table","conversion_output":true,"children_ids":["e3d7a224a01a46afa760f6d785a7fcc5","c52e2309ebe445db8e208d637c5a9d3f","538ca363693d4ceb9e36b96bf69d70d5","66403849aabf4a8faf891d65a2327a15","2980500ba2a445eea560199c996cbf1b","5eac2c222b6044ce8b7d90b2cb67d4e4","d5176c06c91446d4a9e3d65a2de93cad","84f10695a40849c1b93d1c823e5cc67d","9c9272a0e74841d9936abfcc4088d651","49643520dffd4eb5bf5aafe86929f600","2c03aaa1d66a406cbdcabc3cdfa83e4f","a6cdadc58c924dd997cf260de9570d7b","05977dbed27340c790b53cee3103fc72","9ab8af50a6184daabc8653cfb00a7190","58aa6f6f6bfe466d8855b4d55c3f6a8c","18ac64e446354eb88828f2918da772f0","8e8132216f8e40e893857acfa943f9db","97849b6e93174ec195a4e1bcbacebd5c","eb3bd239e7904c7eb23bfe6d8aee2d37","9445f990d67c4162aa8abff95d767a6a","a0aa7c874a784f388ecad213ca656d5f","571b103ed9364c59b7118812185f5889","741a97489a0c4282adfe1a40d3d2c8a8","d57f3f8a1a14419a8ce4452368fed464","e584c5fc5eed460985fbcf0ce169e84b","25b50d3f31bc4d8e87c82e79d1bf336a","deefb263707c4c189c53c09b4d046c96","cb2ff41255a3453da73eaa385e59695c"],"text":"\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline CISplatin (CDDP) & IV over 1 hour & \\(50 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 1.66\\) mg/kg/dose) once daily x 4 doses. & Days 1-4 & Suggest hydrating at 3000 \\(mL / m ^{2} /\\) day using fluid containing at least 0.45\\% NaCl. Suggest achieving urine specific gravity \\(\\leq 1.010\\) prior to start of CISplatin. Hydration fluids may contain supplemental magnesium, calcium and potassium to decrease electrolyte losses associated with CISplatin. Administration of mannitol per institutional guidelines is recommended. & \\begin{tabular}{l}\na. Physical, Ht, Wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr, Ca , Phos, Mg \\\\\nd. ALT, AST, Bilirubin, Urinalysis \\\\\ne. Primary tumor imaging \\\\\nRefer to Protocol Section 7.0 for complete list of observations. \\\\\nOBTAIN OTHER STUDIES AS REQUIRED FOR GOOD PATIENT CARE\n\\end{tabular} \\\\\n\\hline Etoposide (ETOP) & IV over 1 hour & \\(200 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg\\), \\(6.67 mg / kg /\\) dose ) once daily x 3 doses. & Days 1-3 & & \\\\\n\\hline \\multicolumn{5}{|c|}{Myeloid growth factor Administration: Begin 24-48 hours after completion of chemotherapy. If given daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections 4.2 and Appendix II for specific directions.} & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline CISplatin (CDDP) & IV over 1 hour & \\(50 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 1.66\\) mg/kg/dose) once daily x 4 doses. & Days 1-4 & Suggest hydrating at 3000 \\(mL / m ^{2} /\\) day using fluid containing at least 0.45\\% NaCl. Suggest achieving urine specific gravity \\(\\leq 1.010\\) prior to start of CISplatin. Hydration fluids may contain supplemental magnesium, calcium and potassium to decrease electrolyte losses associated with CISplatin. Administration of mannitol per institutional guidelines is recommended. & \\begin{tabular}{l}\na. Physical, Ht, Wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr, Ca , Phos, Mg \\\\\nd. 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This cycle lasts 21 days and this Therapy Delivery Map is on one page.","text_display":" and platelets \\(\\geq 75,000 / \\mu L\\). This cycle lasts 21 days and this Therapy Delivery Map is on one page.","confidence":1,"confidence_rate":1},{"cnt":[[90,614],[2067,614],[2067,1712],[90,1712]],"region":{"top_left_x":90,"top_left_y":614,"width":1977,"height":1099},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1c3a8026e35e4be889249e0b9d7272a5","type":"table","conversion_output":true,"children_ids":["fc8ed0edce634dbf901668867bfce88f","6a2191803c8a40f0a26233b6d945f954","1f4f176113404be287a311ce04f44840","e1d6addfb05a49adb0300c1927b3a444","df440d8ce9224433ac82b1f4ca7a61e3","54ae74c783484b7899b1272b0b42260f","8442a1065ba3478a8697665c4edd88e6","7b54f7f5726b447f9deb0bc70b764e37","cf3c49f7d51e4d9cab4e07838a24a11f","43b68c25d881449aaf32cae51605a6eb","75d42205af22492b9e6764679a03639c","c0f93d5c33c64185bc798b48641abba8","1157f655039a4900960202c7bb71526c","217653f1c2fb4eb49be2d3d281d66a09","d735be8cf6894b64bf7d469f8641d88b","ebb06aa3104144b581de2f2cb3733938","c9b68c3c28904adab609078bdc6dc5b8","adc2400da04a453a8e96c99ba52d64fd","e5f1bacde57c498ca48133c5b63a7d62","2c8046d5f40e4564a602c4fdf8ac91ec","6751a14f8956451c962f0e0fe981a4c3","ae3dc7050fa34754bd691a1a0d90d50d","9bd85edf91ee46789acce1a9fda640bb","bed0834bbb3f481a8fc86bdbbf304e56","8250fa09a8404fe0ad9134400f655430","69b2459ca11845b480c4b60b0f075ccf","787fd83c31834262b46521bc48d2adec","adef191d0c064c3a9b0ffcccebbb363e","0c214aa6b61848e99fa4d95a063b4573","e53009811b4d49aeaf35f86a1f8d1d67","c8ec9ec63a784f9ca0ba9867b9267e1b","43c6333379644220b31942afe2f29405","3aa89dc71f864f76b36fa0bdcf18bcdc","f7f7d223358d411b9e71786207552098","400ee50f8d1e4f3189a3b57cf390beba","8e59870c062648af8c28188d019db5c5","01a70215dcdb4960b7a93020454497c9","5c09f6c5991a48518922e768b38fbec8"],"text":"\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline Cyclophosphamide (CPM) & IV over 6 hours & \\(2100 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 70 mg / kg /\\) dose ) once daily \\(\\times 2\\) doses. & Days 1-2 & Hydrate at 3000 \\(mL / m ^{2} /\\) day using fluid containing at least \\(0.45 \\% NaCl\\). Achieve urine specific gravity \\(\\leq 1.010\\) prior to start of cyclophosphamide. & \\begin{tabular}{l}\na. Physical, Ht, Wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr, Ca, Phos, Mg \\\\\nd. ALT, AST, Bilirubin, Urinalysis, Albumin \\\\\ne. ECG, MUGA/EHCO, CrCl or GFR, Audiogram/BAER (see Section 7.1.1) \\\\\nf. Bilateral BM ASP/Bx \\\\\ng. BM ICC and PCR (Section 15.4) \\\\\nh. Peripheral Blood PCR (Section\n\\end{tabular} \\\\\n\\hline Mesna (MESNA) & IV over 15 minutes & \\(420 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 14\\) mg/kg/dose) immediately prior to each cyclophosphamide and again at 4 and 8 hours after each cyclophosphamide infusion. & Days 1-2 & & \\\\\n\\hline DOXOrubicin (DOXO) & IV over 24 hours & \\(25 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 0.83 mg / kg / dose\\) ) once daily \\(\\times 3\\) doses. & Days 1-3 & & \\begin{tabular}{l}\n15.6) \\\\\ni. Tumor Imaging, Bone scan,\n\\end{tabular} \\\\\n\\hline & & \\begin{tabular}{l}\nPatients < \\(1 2\\) months of age: 0.017 mg/kg/dose once daily x 3 doses \\\\\nPatients \\(\\geq 1 2\\) months and \\(> 1 2 ~ k g\\) : \\(0.67 mg / m ^{2} /\\) dose or 0.022 \\(mg / kg /\\) dose (whichever is LOWER for all patients \\(>12 kg\\) ) once daily x 3 doses \\\\\nPatients \\(\\geq 12\\) months and \\(\\leq 12 kg\\) : \\(0.022 mg / kg /\\) dose once daily \\(\\times 3\\) doses\n\\end{tabular} & Days 1-3 & \\begin{tabular}{l}\nNOTE: Total dose may not exceed 2 mg in 72 hours or 0.67 mg/day for any patient \\\\\nVinCRIStine should be administered prior to start of DOXOrubicin infusion and then daily for a total of 3 doses.\n\\end{tabular} & \\begin{tabular}{l}\nMIBG (Section 7.1.1) \\\\\nj. MRI Spine \\& Neuro Eval (tumors with intraspinal extension only) k. VMA, HVA (if elevated at diagnosis) \\\\\nRefer to Protocol Section 7.0 for complete list of observations and Section 15.0 for sample acquisition or shipment guidelines \\\\\nOBTAIN OTHER STUDIES AS REQUIRED FOR GOOD PATIENT CARE\n\\end{tabular} \\\\\n\\hline \\multicolumn{5}{|l|}{Myeloid growth factor Administration: Begin 24-48 hours after completion of chemotherapy. If given daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections 4.2 and Appendix II for specific directions.} & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline Cyclophosphamide (CPM) & IV over 6 hours & \\(2100 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 70 mg / kg /\\) dose ) once daily \\(\\times 2\\) doses. & Days 1-2 & Hydrate at 3000 \\(mL / m ^{2} /\\) day using fluid containing at least \\(0.45 \\% NaCl\\). Achieve urine specific gravity \\(\\leq 1.010\\) prior to start of cyclophosphamide. & \\begin{tabular}{l}\na. Physical, Ht, Wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr, Ca, Phos, Mg \\\\\nd. ALT, AST, Bilirubin, Urinalysis, Albumin \\\\\ne. ECG, MUGA/EHCO, CrCl or GFR, Audiogram/BAER (see Section 7.1.1) \\\\\nf. Bilateral BM ASP/Bx \\\\\ng. BM ICC and PCR (Section 15.4) \\\\\nh. Peripheral Blood PCR (Section\n\\end{tabular} \\\\\n\\hline Mesna (MESNA) & IV over 15 minutes & \\(420 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 14\\) mg/kg/dose) immediately prior to each cyclophosphamide and again at 4 and 8 hours after each cyclophosphamide infusion. & Days 1-2 & & \\\\\n\\hline DOXOrubicin (DOXO) & IV over 24 hours & \\(25 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg, 0.83 mg / kg / dose\\) ) once daily \\(\\times 3\\) doses. & Days 1-3 & & \\begin{tabular}{l}\n15.6) \\\\\ni. Tumor Imaging, Bone scan,\n\\end{tabular} \\\\\n\\hline & & \\begin{tabular}{l}\nPatients < \\(1 2\\) months of age: 0.017 mg/kg/dose once daily x 3 doses \\\\\nPatients \\(\\geq 1 2\\) months and \\(> 1 2 ~ k g\\) : \\(0.67 mg / m ^{2} /\\) dose or 0.022 \\(mg / kg /\\) dose (whichever is LOWER for all patients \\(>12 kg\\) ) once daily x 3 doses \\\\\nPatients \\(\\geq 12\\) months and \\(\\leq 12 kg\\) : \\(0.022 mg / kg /\\) dose once daily \\(\\times 3\\) doses\n\\end{tabular} & Days 1-3 & \\begin{tabular}{l}\nNOTE: Total dose may not exceed 2 mg in 72 hours or 0.67 mg/day for any patient \\\\\nVinCRIStine should be administered prior to start of DOXOrubicin infusion and then daily for a total of 3 doses.\n\\end{tabular} & \\begin{tabular}{l}\nMIBG (Section 7.1.1) \\\\\nj. MRI Spine \\& Neuro Eval (tumors with intraspinal extension only) k. VMA, HVA (if elevated at diagnosis) \\\\\nRefer to Protocol Section 7.0 for complete list of observations and Section 15.0 for sample acquisition or shipment guidelines \\\\\nOBTAIN OTHER STUDIES AS REQUIRED FOR GOOD PATIENT CARE\n\\end{tabular} \\\\\n\\hline \\multicolumn{5}{|l|}{Myeloid growth factor Administration: Begin 24-48 hours after completion of chemotherapy. If given daily, continue until post-nadir ANC \\(>1500 / \\mu L\\). See sections 4.2 and Appendix II for specific directions.} & 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AST \\(<3 \\times\\) upper normal","text_display":"\n5. AST \\(<3 \\times\\) upper normal","confidence":0.995610237121582,"confidence_rate":0.999858093096267},{"cnt":[[245,997],[1729,997],[1729,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":996,"width":1486,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7cdc66460f9441f9e541ee7fa828acd","type":"text","conversion_output":true,"text":"6. Shortening fraction \\(\\geq 27 \\%\\), or ejection fraction \\(\\geq 50 \\%\\), no clinical congestive heart failure.","text_display":"\n6. Shortening fraction \\(\\geq 27 \\%\\), or ejection fraction \\(\\geq 50 \\%\\), no clinical congestive heart failure.","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[245,1036],[1880,1036],[1880,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1035,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40e185f0678340fcb5dec878edaaca64","type":"text","conversion_output":true,"text":"7. Creatinine clearance or \\(GFR \\geq 60 mL / min / 1.73 m^{2}\\) (If a creatinine clearance is performed at end","text_display":"\n7. Creatinine clearance or \\(GFR \\geq 60 mL / min / 1.73 m^{2}\\) (If a creatinine clearance is performed at end","confidence":0.90478515625,"confidence_rate":0.9991665328612336},{"cnt":[[339,1079],[1880,1079],[1880,1130],[339,1130]],"region":{"top_left_x":339,"top_left_y":1078,"width":1541,"height":53},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67e589268c074f2593ed70eb25691c6b","type":"text","conversion_output":true,"text":"induction and the result is \\(<100 ml / min / 1.73 m^{2}\\), a GFR must then be performed using a nuclear","text_display":" induction and the result is \\(<100 ml / min / 1.73 m^{2}\\), a GFR must then be performed using a nuclear","confidence":1,"confidence_rate":1},{"cnt":[[339,1128],[1880,1128],[1880,1173],[339,1173]],"region":{"top_left_x":339,"top_left_y":1127,"width":1541,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d84cfd3f737473bb476e39349597a4c","type":"text","conversion_output":true,"text":"blood sampling method or iothalamate clearance method. Camera method is NOT allowed as","text_display":" blood sampling method or iothalamate clearance method. Camera method is NOT allowed as","confidence":1,"confidence_rate":1},{"cnt":[[339,1173],[1880,1173],[1880,1218],[339,1218]],"region":{"top_left_x":339,"top_left_y":1173,"width":1541,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e2a22e33a534687ab88eede24e2b2b1","type":"text","conversion_output":true,"text":"measure of GFR prior to or during Consolidation therapy for patients with GFR or creatinine","text_display":" measure of GFR prior to or during Consolidation therapy for patients with GFR or creatinine","confidence":1,"confidence_rate":1},{"cnt":[[339,1212],[892,1212],[892,1261],[339,1261]],"region":{"top_left_x":339,"top_left_y":1211,"width":553,"height":51},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"597a8d13d51146fc952936d65c092734","type":"text","conversion_output":true,"text":"clearance of \\(<100 ml / min / 1.73 m^{2}\\).)","text_display":" clearance of \\(<100 ml / min / 1.73 m^{2}\\).)","confidence":0.994145393371582,"confidence_rate":0.9998969910597404},{"cnt":[[245,1250],[1609,1250],[1609,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1250,"width":1366,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7079d3aabb044eb29a3fbc083ac95605","type":"figure_label","conversion_output":false,"text":"PATIENTS WITH CREATININE CLEARANCE OR GFR \\(\\geq 1 0 0 ~ M L / M I N / 1 . 7 3 M { }^{ 2 }\\)","text_display":"","confidence":0.06557022827304299,"confidence_rate":0.968814824291909},{"cnt":[[150,1298],[2037,1298],[2037,2322],[150,2322]],"region":{"top_left_x":150,"top_left_y":1297,"width":1887,"height":1026},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e0cfd9b57f84a84a4568ffdff3309de","type":"table","conversion_output":true,"children_ids":["91e846b0b8bf431ebe7b244925bb52fb","a6113a5cb02c47e098c229e0d03df8ad","7819e02430214f08be19c372befd61f2","ed66c31fc3354e719772c8b4c08ef356","60670b1292304b3abf83be9f648ca4d7","93bc7659b0eb4ce5b98548222d0457a2","81276e01a2084d9ca369fea1790f7827","7a9fd533994942f7b77f5a8a1c4f3ecd","741ea765ab9946d0858025102136242d","a09ac5edadce4e02ad2c99cad98a3f20","3b789f5f4ca64eb8af746cd0a4ae1175","262c2ec0024a4b31b05253c520617b4e","59ca6a59a8964611a446b1b30c082539","51bae57a94b442eead9341955e71bbc9","15cdd842c45443d7a8d0db9055f0832c","bffd79c7893a43e792b8d684ba1abea9","92079e71cc254c58a4a5acbc1248edb6","aee6b2a0c2274b73ab14cc0aefe5a324","f3206a811d2c405c95c2533a187b76e2","63cf1f94dc144f5686e25ee4c75a2bfa","075de997df7649da83fa952d8cc8898d","810b551d20054778839699f2e3448d25","115537d1bb17456094b223ae763297b7","13790d9bdca94c238c5cc892c1907d8c","95bfc2b0febd4003a9d7f6a48bff3f04","7a9e38d1aefb46bbbe9c6c0e8c5f2e0b","d0a94b9db59e46a5ad2e7d58a2d282ad","93c71c7aaf3c4552a6d369651d2590a2","578b04a104fb47cba14cea715149dfe6","dc9417c527e14f7fa12c815fa20baa0f","22958570fb6e4b7590fab977ace5fe59","b340d2c8f06749c898b9e68bb995fae1"],"selected_labels":["7079d3aabb044eb29a3fbc083ac95605"],"text":"\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline Melphalan (MEL) & IV over 15-30 minutes & \\(70 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg , 2.3 mg / kg /\\) dose ) once daily x 3 doses. & Days -7, 6 and -5 & Must be infused within 1 hour of preparation. & \\\\\n\\hline Etoposide (ETOP) & IV over 24 hours & \\(338 mg / m ^{2} /\\) dose (or if \\(\\leq 12\\) kg, \\(11.3 mg / kg /\\) dose) once daily x 4 doses. & Days -7, 6, -5 and 4 & & \\\\\n\\hline & IV over 24 hours & \\(425 mg / m ^{2} /\\) dose (or if \\(\\leq 12\\) kg, \\(14.2 mg / kg /\\) dose) once daily x 4 doses. & Days -7, 6, -5 and 4 & & \\begin{tabular}{l}\na. Physical exam, ht, wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr \\\\\nd. \\(Ca ^{++}, PO _{4}, Mg ^{++}\\) \\\\\ne. ALT, AST, Bilirubin, Albumin \\\\\nf. Triglycerides \\\\\ng. ECG, MUGA/ECHO, GFR, urinalysis\n\\end{tabular} \\\\\n\\hline Filgrastim (GCSF) & & & & & \\begin{tabular}{l}\nk. Tumor imaging, Bone scan, MIBG (Section 7.1.2) \\\\\n1. MRI spine \\& neurologic evaluation (tumors with intraspinal extension only) \\\\\nm. VMA/HVA (if elevated at diagnosis) \\\\\nn. Peripheral Blood Immune assessments (Section 15.8) \\\\\no. Peripheral blood for Immune recovery (Section 7.1.2) \\\\\nRefer to Protocol Section 7.0 for complete list of observations and Section 15.0 for sample acquisition or shipment guidelines \\\\\nOBTAIN OTHER STUDIES AS REQUIRED FOR GOOD PATIENT CARE\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{PATIENTS WITH CREATININE CLEARANCE OR GFR \\(\\geq 1 0 0 ~ M L / M I N / 1 . 7 3 M { }^{ 2 }\\)}\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline Melphalan (MEL) & IV over 15-30 minutes & \\(70 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg , 2.3 mg / kg /\\) dose ) once daily x 3 doses. & Days -7, 6 and -5 & Must be infused within 1 hour of preparation. & \\\\\n\\hline Etoposide (ETOP) & IV over 24 hours & \\(338 mg / m ^{2} /\\) dose (or if \\(\\leq 12\\) kg, \\(11.3 mg / kg /\\) dose) once daily x 4 doses. & Days -7, 6, -5 and 4 & & \\\\\n\\hline & IV over 24 hours & \\(425 mg / m ^{2} /\\) dose (or if \\(\\leq 12\\) kg, \\(14.2 mg / kg /\\) dose) once daily x 4 doses. & Days -7, 6, -5 and 4 & & \\begin{tabular}{l}\na. Physical exam, ht, wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr \\\\\nd. \\(Ca ^{++}, PO _{4}, Mg ^{++}\\) \\\\\ne. ALT, AST, Bilirubin, Albumin \\\\\nf. Triglycerides \\\\\ng. ECG, MUGA/ECHO, GFR, urinalysis\n\\end{tabular} \\\\\n\\hline Filgrastim (GCSF) & & & & & \\begin{tabular}{l}\nk. Tumor imaging, Bone scan, MIBG (Section 7.1.2) \\\\\n1. MRI spine \\& neurologic evaluation (tumors with intraspinal extension only) \\\\\nm. VMA/HVA (if elevated at diagnosis) \\\\\nn. Peripheral Blood Immune assessments (Section 15.8) \\\\\no. Peripheral blood for Immune recovery (Section 7.1.2) \\\\\nRefer to Protocol Section 7.0 for complete list of observations and Section 15.0 for sample acquisition or shipment guidelines \\\\\nOBTAIN OTHER STUDIES AS REQUIRED FOR GOOD PATIENT CARE\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.5241557892040873,"confidence_rate":0.9991535644530395},{"cnt":[[161,1297],[386,1297],[386,2323],[161,2323]],"region":{"top_left_x":160,"top_left_y":1297,"width":227,"height":1027},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91e846b0b8bf431ebe7b244925bb52fb","type":"table_column","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[399,1297],[574,1297],[574,2323],[399,2323]],"region":{"top_left_x":399,"top_left_y":1297,"width":176,"height":1027},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6113a5cb02c47e098c229e0d03df8ad","type":"table_column","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[592,1297],[992,1297],[992,2323],[592,2323]],"region":{"top_left_x":591,"top_left_y":1297,"width":402,"height":1027},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7819e02430214f08be19c372befd61f2","type":"table_column","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[1018,1297],[1185,1297],[1185,2323],[1018,2323]],"region":{"top_left_x":1018,"top_left_y":1297,"width":168,"height":1027},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed66c31fc3354e719772c8b4c08ef356","type":"table_column","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[1209,1297],[1460,1297],[1460,2323],[1209,2323]],"region":{"top_left_x":1208,"top_left_y":1297,"width":253,"height":1027},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60670b1292304b3abf83be9f648ca4d7","type":"table_column","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[1475,1297],[2017,1297],[2017,2323],[1475,2323]],"region":{"top_left_x":1475,"top_left_y":1297,"width":542,"height":1027},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93bc7659b0eb4ce5b98548222d0457a2","type":"table_column","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[150,1301],[2036,1301],[2036,1381],[150,1381]],"region":{"top_left_x":150,"top_left_y":1301,"width":1887,"height":81},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81276e01a2084d9ca369fea1790f7827","type":"table_row","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[150,1379],[2038,1379],[2038,1520],[150,1520]],"region":{"top_left_x":150,"top_left_y":1379,"width":1889,"height":142},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a9fd533994942f7b77f5a8a1c4f3ecd","type":"table_row","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[150,1505],[2038,1505],[2038,1628],[150,1628]],"region":{"top_left_x":150,"top_left_y":1504,"width":1889,"height":125},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"741ea765ab9946d0858025102136242d","type":"table_row","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[150,1622],[2036,1622],[2036,1763],[150,1763]],"region":{"top_left_x":150,"top_left_y":1621,"width":1887,"height":142},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a09ac5edadce4e02ad2c99cad98a3f20","type":"table_row","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[150,1750],[2034,1750],[2034,2315],[150,2315]],"region":{"top_left_x":150,"top_left_y":1749,"width":1884,"height":566},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b789f5f4ca64eb8af746cd0a4ae1175","type":"table_row","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"","text_display":""},{"cnt":[[172,1310],[278,1310],[278,1338],[172,1338]],"region":{"top_left_x":171,"top_left_y":1309,"width":107,"height":30},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"262c2ec0024a4b31b05253c520617b4e","type":"simple_cell","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"DRUG","text_display":"DRUG","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[410,1310],[538,1310],[538,1338],[410,1338]],"region":{"top_left_x":409,"top_left_y":1309,"width":129,"height":30},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59ca6a59a8964611a446b1b30c082539","type":"simple_cell","conversion_output":false,"parent_id":"9e0cfd9b57f84a84a4568ffdff3309de","text":"ROUTE","text_display":"ROUTE","cell_r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GFR will be calculated","text_display":" achieve an area under the concentration versus time curve (AUC) of 4.1 per dose. GFR will be calculated","confidence":0.994631290435791,"confidence_rate":0.9999515041230366},{"cnt":[[249,1697],[1338,1697],[1338,1742],[249,1742]],"region":{"top_left_x":249,"top_left_y":1697,"width":1090,"height":46},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16c0b197c54a4ee59f21ff42d786cbfc","type":"text","conversion_output":true,"text":"using a blood sampling method. Daily dose should not exceed \\(300 mg / m ^{2}\\).","text_display":" using a blood sampling method. Daily dose should not exceed \\(300 mg / m ^{2}\\).","confidence":0.9194068908691406,"confidence_rate":0.9990770580338938},{"cnt":[[155,1766],[2000,1766],[2000,1906],[155,1906]],"region":{"top_left_x":154,"top_left_y":1766,"width":1847,"height":140},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d16eb32ff224ac6ac60c3acf13844da","type":"math","conversion_output":true,"text":"\\[\n\\text { Total Dose }(mg) / \\text { day }=\\left\\{\\frac{(\\text { Corrected GFR } \\text { × surface area })}{1.73}+(15 \\text { x surface area })\\right\\} \\times 4.1\n\\]","text_display":"\n\\[\n\\text { Total Dose }(mg) / \\text { day }=\\left\\{\\frac{(\\text { Corrected GFR } \\text { × surface area })}{1.73}+(15 \\text { x surface area })\\right\\} \\times 4.1\n\\]","confidence":0.3456745944689547,"confidence_rate":0.9903895923087349},{"cnt":[[247,1925],[1489,1925],[1489,1968],[247,1968]],"region":{"top_left_x":247,"top_left_y":1925,"width":1242,"height":43},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50fddbb0f2ee4ac2869ac70f8f349699","type":"text","conversion_output":true,"text":"Example: Patient's GFR is \\(86 mL / min / 1.73 m2\\), they weigh 14.6 kg and their BSA is \\(0.61 m^{2}\\) :","text_display":"\n\nExample: Patient's GFR is \\(86 mL / min / 1.73 m2\\), they weigh 14.6 kg and their BSA is \\(0.61 m^{2}\\) :","confidence":0.90283203125,"confidence_rate":0.9991692984369754},{"cnt":[[370,1994],[1652,1994],[1652,2069],[370,2069]],"region":{"top_left_x":369,"top_left_y":1993,"width":1284,"height":76},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d141a154a4a4b06be74a663f523c717","type":"math","conversion_output":true,"text":"\\[\n\\text { Total dose }(mg) / \\text { day }=\\left\\{\\frac{\\left(86 mL / \\min / 1.73 m^{2} \\times 0.61 m^{2}\\right)}{1.73}+\\left(15 \\times 0.61 m^{2}\\right)\\right\\} \\times 4.1=162 mg\n\\]","text_display":"\n\\[\n\\text { Total dose }(mg) / \\text { day }=\\left\\{\\frac{\\left(86 mL / \\min / 1.73 m^{2} \\times 0.61 m^{2}\\right)}{1.73}+\\left(15 \\times 0.61 m^{2}\\right)\\right\\} \\times 4.1=162 mg\n\\]","confidence":0.515625,"confidence_rate":0.9948385574922052},{"cnt":[[245,2069],[1854,2069],[1854,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2068,"width":1611,"height":44},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ddf9b0af4604c1097b8f211095cb61b","type":"text","conversion_output":true,"text":"NOTE: if lab reports raw GFR in \\(mL / min\\) instead of corrected GFR in \\(mL / min / 1.73 m^{2}\\), convert Raw GFR to corrected GFR as","text_display":"\n\nNOTE: if lab reports raw GFR in \\(mL / min\\) instead of corrected GFR in \\(mL / min / 1.73 m^{2}\\), convert Raw GFR to corrected GFR as","confidence":0.8970227241516113,"confidence_rate":0.9992805630001693},{"cnt":[[247,2110],[354,2110],[354,2142],[247,2142]],"region":{"top_left_x":247,"top_left_y":2109,"width":108,"height":33},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59342c4615bb4eccbb9e206905cacb28","type":"text","conversion_output":true,"text":"follows:","text_display":" follows:","confidence":1,"confidence_rate":1},{"cnt":[[288,2140],[1497,2140],[1497,2181],[288,2181]],"region":{"top_left_x":287,"top_left_y":2139,"width":1211,"height":42},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5bb06af44f143c68bec9c9711cf4a27","type":"text","conversion_output":true,"text":"Divide Raw GFR in \\(mL / min\\) by the patient's surface area in \\(m ^{2}\\), then multiply result by \\(1.73 m^{2}\\).","text_display":"\n\nDivide Raw GFR in \\(mL / min\\) by the patient's surface area in \\(m ^{2}\\), then multiply result by \\(1.73 m^{2}\\).","confidence":0.9980475902557373,"confidence_rate":0.9999855236738155},{"cnt":[[288,2176],[1850,2176],[1850,2219],[288,2219]],"region":{"top_left_x":287,"top_left_y":2176,"width":1563,"height":44},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"527bb22d47a94bef956d0887db0fdaba","type":"text","conversion_output":true,"text":"Example: Raw GFR is \\(3 0 . 3 ~ m L / m i n , B S A = 0 . 6 1 ~ m ^{2}: \\quad 30.3 mL / min\\) divided by \\(0.61 m^{2}\\) then multiplied by \\(1.73 m^{2}=86\\)","text_display":"\nExample: Raw GFR is \\(3 0 . 3 ~ m L / m i n , B S A = 0 . 6 1 ~ m ^{2}: \\quad 30.3 mL / min\\) divided by \\(0.61 m^{2}\\) then multiplied by \\(1.73 m^{2}=86","confidence":0.7931857105957435,"confidence_rate":0.9985529361494102},{"cnt":[[245,2213],[397,2213],[397,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2212,"width":154,"height":38},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2f4086957094ecca267ee4ddfcad9a8","type":"text","conversion_output":true,"text":"\\(mL / min / m ^{2}\\)","text_display":" mL / min / m ^{2}\\)","confidence":1,"confidence_rate":1},{"cnt":[[146,2363],[331,2363],[331,2400],[146,2400]],"region":{"top_left_x":146,"top_left_y":2363,"width":185,"height":37},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc657de528cb4ed58c012a42299b5ed1","type":"section_header","conversion_output":false,"children_ids":["3d34f4dccc6d42699449fd6ee7b0db05"],"text":"","text_display":""},{"cnt":[[146,2363],[329,2363],[329,2400],[146,2400]],"region":{"top_left_x":146,"top_left_y":2363,"width":183,"height":37},"line":115,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d34f4dccc6d42699449fd6ee7b0db05","type":"text","conversion_output":true,"parent_id":"bc657de528cb4ed58c012a42299b5ed1","text":"Page 2 of 4","text_display":"\n\n\\section*{Page 2 of 4}","confidence":1,"confidence_rate":1},{"cnt":[[1749,2587],[1876,2587],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2586,"width":128,"height":42},"line":116,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4df8a9fe75045d48f220a9125647d1f","type":"page_info","conversion_output":false,"text":"Page 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Oncology Group","text_display":"\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[653,131],[1648,131],[1648,161],[653,161]],"region":{"top_left_x":653,"top_left_y":131,"width":995,"height":31},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d21f44e1aee743e6a7c16f356fc803b5","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.7791332746713772,"confidence_rate":0.9968851965540881},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b2e5d67d39149e89e51950f8afba486","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[642,236],[1050,238],[1858,249],[1862,251],[1866,255],[1866,272],[1864,292],[1862,294],[309,294],[309,255],[311,251],[317,240],[326,236]],"region":{"top_left_x":309,"top_left_y":236,"width":1557,"height":58},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94b17e8cb13a49b6817a21d2bfc3999d","type":"text","conversion_output":true,"text":"Consolidation Regimen A: Single HSCT (CEM): Patients with altered renal function who are \\(\\leq 12 kg\\)","text_display":"\n\nConsolidation Regimen A: Single HSCT (CEM): Patients with altered renal function who are \\(\\leq 12 kg\\)","confidence":1,"confidence_rate":1},{"cnt":[[303,292],[1858,292],[1858,342],[303,342]],"region":{"top_left_x":302,"top_left_y":292,"width":1557,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ceb3117ce867455baefae26b27cfbdcd","type":"text","conversion_output":true,"text":"PATIENTS WITH GFR \\(< 1 0 0 ~ M L / MIN / 1 . 7 3 M 2 a n d ^{ 2 } \\geq 6 0 ~ M L / MIN / 1 . 7 3 M ~ ^{ 2 }\\) AND ARE \\(\\leq 1 2 ~ K G\\)","text_display":" PATIENTS WITH GFR \\(< 1 0 0 ~ M L / MIN / 1 . 7 3 M 2 a n d ^{ 2 } \\geq 6 0 ~ M L / MIN / 1 . 7 3 M ~ ^{ 2 }\\) AND ARE \\(\\leq 1 2 ~ K G\\)","confidence":0.08021497654491218,"confidence_rate":0.9807790846814403},{"cnt":[[150,374],[2007,374],[2007,1573],[150,1573]],"region":{"top_left_x":150,"top_left_y":373,"width":1857,"height":1200},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12f83c4c53bb4ee989455852d6c93232","type":"table","conversion_output":true,"children_ids":["cdf9a7f3632749e583209aa04b3f4bea","425fc1fa95cc419cb8184bc6d64c597c","0204bb94d2844fc6800853dc109c0465","5711ddbda36346c8b14b621268a819d1","b94997aa19c440ff9999581a2ee267c9","68afb58d3e9d46a88052ce376deba74e","aa8486d552f44fb0bb69b8697eacd642","4251f603bc62410d8605997bc95c8a68","46d953023ac3420fbf81f9006e5701d1","2d4c9d3064514175ac73c771a2937f33","bcf473e5eff74b8f93e0aae443e43b9e","147393f3defd435989d9f14742d5f431","19dd0c408d154b1ca2c04b17a05be630","f41250e7cd0f4a838ab9da9429fc1fa2","c434e2e3965843c7a7800e91f65ba0ee","dda86f901e30442285e97aa23ecb885b","46ff9dd035a64bd98c3762f4dee45c33","767d47783bd0490c836561efdf55101c","0ab86eb109fc468a934b7d6d3fb52d53","a77d03d3e0854337aa871b1e2f4100ef","da106df8f6f641458c82769bc556ca06","8db1b6b8838348569ca75315269eb77a","07fe61b5c7014936ba623ecdf9ca9539","3c47efd5671e494bb9dcdd18c1d7c763","8f8d39db45b1412dbaa8555fdcc18670","687bd5bdfef94608b71246663ab87583","cce06f8b604e41c1920f04614f72483b","dc5e54ecb4074a9b9dbae9e38333e071","5b3c3b193a414beb810dad4b9dbfee28","5eb311922d9f4e37aab703602a7f3f7b","c095046dab4c425ab438bff76ac7d5ca","618d43fd515a474bb11d6902384c817f","9a7319013a1349369a401b2c637eb36d","798843cce8c84b528fb944201b2d8b3d","706b71b92d984d02b81c7ad2fec81bdd","114c2421170b4a4cbc0bd226b1b9d1f4"],"text":"\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline Melphalan (MEL) & IV over 15-30 minutes & \\(2 mg / kg /\\) dose once daily x 3 doses. & Days -7, -6 and -5 & Must be infused within 1 hour of preparation. & \\\\\n\\hline Etoposide (ETOP) & IV over 24 hours & \\(6.7 mg / kg /\\) dose once daily x 4 doses. & Days -7, -6, -5 and -4 & & \\\\\n\\hline CARBOplatin (CARB) & IV over 24 hours & See Calvert Formula* below for dose calculation; give dose once daily x 4 doses. Also calculate dose as 10 \\(mg / kg\\) and give LOWEST calculated dose as described below & Days -7, -6, -5 and -4 & *See sample Calvert dose calculation below. & \\\\\n\\hline Filgrastim (GCSF) & SubQ (OR) IV (SubQ preferred) & 5 micrograms/kg once daily and continuing once daily until post-nadir ANC \\(>2000 / \\mu L\\) for 3 consecutive days. & Day 0 until ANC recovery & & \\begin{tabular}{l}\na. Physical exam, ht, wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr \\\\\nd. \\(Ca ^{++}, PO _{4}, Mg ^{++}\\) \\\\\ne. ALT, AST, Bilirubin, Albumin \\\\\nf. Triglycerides \\\\\ng. ECG, MUGA/ECHO, GFR, urinalysis \\\\\nh. Bilateral BM aspirate/bx., Audiogram/BAER (Section 7.1.2) \\\\\ni. BM PCR (Section 15.4) \\\\\nj. Peripheral blood PCR (Section 15.6) \\\\\nk. Tumor imaging, Bone scan, MIBG (Section 7.1.2) \\\\\n1. MRI spine \\& neurologic evaluation (tumors with intraspinal extension only) \\\\\nm. VMA/HVA (if elevated at diagnosis) \\\\\nn. Peripheral Blood Immune assessments (Section 15.8) \\\\\no. Peripheral blood for Immune recovery (Section 7.1.2) \\\\\nRefer to Protocol Section 7.0 for complete list of observations and Section 15.0 for sample acquisition or shipment guidelines \\\\\nOBTAIN OTHER STUDIES AS REQUIRED FOR GOOD PATIENT CARE\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline Melphalan (MEL) & IV over 15-30 minutes & \\(2 mg / kg /\\) dose once daily x 3 doses. & Days -7, -6 and -5 & Must be infused within 1 hour of preparation. & \\\\\n\\hline Etoposide (ETOP) & IV over 24 hours & \\(6.7 mg / kg /\\) dose once daily x 4 doses. & Days -7, -6, -5 and -4 & & \\\\\n\\hline CARBOplatin (CARB) & IV over 24 hours & See Calvert Formula* below for dose calculation; give dose once daily x 4 doses. Also calculate dose as 10 \\(mg / kg\\) and give LOWEST calculated dose as described below & Days -7, -6, -5 and -4 & *See sample Calvert dose calculation below. & \\\\\n\\hline Filgrastim (GCSF) & SubQ (OR) IV (SubQ preferred) & 5 micrograms/kg once daily and continuing once daily until post-nadir ANC \\(>2000 / \\mu L\\) for 3 consecutive days. & Day 0 until ANC recovery & & \\begin{tabular}{l}\na. Physical exam, ht, wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr \\\\\nd. \\(Ca ^{++}, PO _{4}, Mg ^{++}\\) \\\\\ne. ALT, AST, Bilirubin, Albumin \\\\\nf. Triglycerides \\\\\ng. ECG, MUGA/ECHO, GFR, urinalysis \\\\\nh. Bilateral BM aspirate/bx., Audiogram/BAER (Section 7.1.2) \\\\\ni. BM PCR (Section 15.4) \\\\\nj. Peripheral blood PCR (Section 15.6) \\\\\nk. Tumor imaging, Bone scan, MIBG (Section 7.1.2) \\\\\n1. MRI spine \\& neurologic evaluation (tumors with intraspinal extension only) \\\\\nm. VMA/HVA (if elevated at diagnosis) \\\\\nn. Peripheral Blood Immune assessments (Section 15.8) \\\\\no. 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dosing:}","confidence":0.9926791191101074,"confidence_rate":0.9998367286624602},{"cnt":[[262,1641],[1837,1641],[1837,1691],[262,1691]],"region":{"top_left_x":262,"top_left_y":1641,"width":1575,"height":50},"line":131,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc2cc1c7b8084cb09f12bbc11c487fe2","type":"text","conversion_output":true,"text":"Patients with GFR \\(<100 mL / min / 1.73 m^{2}\\) who are \\(\\leq 12 kg\\) will be dosed according to the formula below to","text_display":"\n\nPatients with GFR \\(<100 mL / min / 1.73 m^{2}\\) who are \\(\\leq 12 kg\\) will be dosed according to the formula below to","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1824,1689],[1824,1729],[245,1729]],"region":{"top_left_x":244,"top_left_y":1688,"width":1581,"height":42},"line":132,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93cd267e91da43b895321198b540a645","type":"text","conversion_output":true,"text":"achieve an area under the concentration versus time curve (AUC) of 4.1 per dose. GFR will be calculated","text_display":" achieve an area under the concentration versus time curve (AUC) of 4.1 per dose. GFR will be calculated","confidence":0.9756200204137713,"confidence_rate":0.9997776635337352},{"cnt":[[245,1727],[1846,1727],[1846,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1727,"width":1602,"height":46},"line":133,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"697803dffd2f4e039f4a7d865a43509b","type":"text","conversion_output":true,"text":"using a blood sampling method. Daily dose should not exceed \\(1 0 ~ m g / k g\\). Calculate dose by Calvert formula","text_display":" using a blood sampling method. Daily dose should not exceed \\(1 0 ~ m g / k g\\). Calculate dose by Calvert formula","confidence":0.6702486462891102,"confidence_rate":0.9966150088104683},{"cnt":[[245,1766],[1656,1766],[1656,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1766,"width":1413,"height":46},"line":134,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c0610e503444d0a9a43aed7d6598d08","type":"text","conversion_output":true,"text":"below and also calculate dose by weight ( \\(10 mg / kg\\) ). Give LOWER of the two calculated doses.","text_display":" below and also calculate dose by weight ( \\(10 mg / kg\\) ). 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Cyclophosphamide)}","confidence":1,"confidence_rate":1},{"cnt":[[1371,296],[1489,296],[1489,337],[1371,337]],"region":{"top_left_x":1370,"top_left_y":296,"width":119,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d29a361d2fed49a49c3783faf880b25b","type":"text","conversion_output":true,"text":"COG \\#","text_display":"\n\nCOG \\#","confidence":1,"confidence_rate":1},{"cnt":[[262,346],[1128,346],[1128,391],[262,391]],"region":{"top_left_x":262,"top_left_y":345,"width":866,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3dae8865b28474a808ac0851b38e04e","type":"text","conversion_output":true,"text":"Regimen B: Experimental arm of tandem myeloablative","text_display":"\nRegimen B: Experimental arm of tandem myeloablative","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[262,391],[870,391],[870,436],[262,436]],"region":{"top_left_x":262,"top_left_y":391,"width":609,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe4c1717ec82445089193629b7efe16c","type":"text","conversion_output":true,"text":"therapy (Regimen B) with thiotepa and","text_display":" therapy (Regimen B) with thiotepa and","confidence":1,"confidence_rate":1},{"cnt":[[262,434],[988,434],[988,479],[262,479]],"region":{"top_left_x":262,"top_left_y":433,"width":727,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ce6c7ad744e4cb0ae9fcb4aecf6f1f3","type":"text","conversion_output":true,"text":"cyclophosphamide regimen followed by CEM.","text_display":" cyclophosphamide regimen followed by CEM.","confidence":1,"confidence_rate":1},{"cnt":[[1343,406],[1846,406],[1846,537],[1343,537]],"region":{"top_left_x":1342,"top_left_y":406,"width":504,"height":132},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb169bc2e72846c6a560de8049c01729","type":"table","conversion_output":true,"text":"\\begin{tabular}{c}\n\\hline Patient name or initials \\\\\n\\hline DOB\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{c}\n\\hline Patient name or initials \\\\\n\\hline DOB\n\\end{tabular}","confidence":0.9917066079797223,"confidence_rate":0.9998300557987384},{"cnt":[[245,541],[1695,541],[1695,587],[245,587]],"region":{"top_left_x":244,"top_left_y":541,"width":1452,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3b09622aeae4c498f223008eff558a9","type":"text","conversion_output":true,"text":"Patients should begin consolidation therapy within 8 weeks of beginning Cycle 6 of induction.","text_display":"\n\nPatients should begin consolidation therapy within 8 weeks of beginning Cycle 6 of induction.","confidence":1,"confidence_rate":1},{"cnt":[[245,584],[1313,584],[1313,629],[245,629]],"region":{"top_left_x":244,"top_left_y":584,"width":1069,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7a0aec3933d456185b1d7da9cda7dac","type":"text","conversion_output":true,"text":"This Therapy Delivery Map is on two pages. This cycle lasts 50 days","text_display":"\nThis Therapy Delivery Map is on two pages. This cycle lasts 50 days","confidence":1,"confidence_rate":1},{"cnt":[[245,627],[1742,627],[1742,672],[245,672]],"region":{"top_left_x":244,"top_left_y":627,"width":1499,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab143a7ff3a3422baed31dece8d9a7aa","type":"text","conversion_output":true,"text":"Criteria to Start Consolidation Regimen B: Tandem HSCT \\#1 (Thiotepa and Cyclophosphamide)","text_display":"\nCriteria to Start Consolidation Regimen B: Tandem HSCT \\#1 (Thiotepa and Cyclophosphamide)","confidence":1,"confidence_rate":1},{"cnt":[[339,670],[1820,670],[1820,715],[339,715]],"region":{"top_left_x":339,"top_left_y":670,"width":1481,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df39e05ca3dd4fe680fb333665ed8980","type":"text","conversion_output":true,"text":"1. No evidence of disease progression: defined as increase in tumor size of \\(>25 \\%\\) or new lesions.","text_display":"\n1. No evidence of disease progression: defined as increase in tumor size of \\(>25 \\%\\) or new lesions.","confidence":0.9878039360046387,"confidence_rate":0.9998820161311578},{"cnt":[[337,713],[1210,713],[1210,761],[337,761]],"region":{"top_left_x":337,"top_left_y":713,"width":873,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed876903bd604cc7a6e1fdaa338e9a60","type":"text","conversion_output":true,"text":"2. Recovery from last induction course of chemotherapy.","text_display":"\n2. Recovery from last induction course of chemotherapy.","confidence":1,"confidence_rate":1},{"cnt":[[339,761],[780,761],[780,797],[339,797]],"region":{"top_left_x":339,"top_left_y":760,"width":441,"height":38},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3089ae3dc4a49bf84941f6b94732b40","type":"text","conversion_output":true,"text":"3.No uncontrolled infection.","text_display":"\n3.No uncontrolled infection.","confidence":0.515625,"confidence_rate":0.9801281157430707},{"cnt":[[337,797],[1880,797],[1880,849],[337,849]],"region":{"top_left_x":337,"top_left_y":797,"width":1543,"height":52},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8812aa49b26c422081b96fc995d62f16","type":"text","conversion_output":true,"text":"4. Minimum frozen PBSC of \\(4 \\times 10^{6} CD 34\\) cells \\(/ kg\\) as 2 aliquots; i.e. \\(2 \\times 10^{6} CD 34\\) cells \\(/ kg\\) for each","text_display":"\n4. Minimum frozen PBSC of \\(4 \\times 10^{6} CD 34\\) cells \\(/ kg\\) as 2 aliquots; i.e. \\(2 \\times 10^{6} CD 34\\) cells \\(/ kg\\) for each","confidence":0.6914612529213287,"confidence_rate":0.997368125450476},{"cnt":[[337,842],[1880,842],[1880,892],[337,892]],"region":{"top_left_x":337,"top_left_y":842,"width":1543,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83f241a0c05147338147b7f879252ea5","type":"text","conversion_output":true,"text":"transplant are mandatory. A third aliquot of \\(2 \\times 10^{6} CD 34\\) cells \\(/ kg\\) is strongly recommended for","text_display":" transplant are mandatory. A third aliquot of \\(2 \\times 10^{6} CD 34\\) cells \\(/ kg\\) is strongly recommended for","confidence":0.87255859375,"confidence_rate":0.9988254707224973},{"cnt":[[339,889],[479,889],[479,935],[339,935]],"region":{"top_left_x":339,"top_left_y":889,"width":141,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56b2b79d80d04f198456e0fcfcbb0aa5","type":"text","conversion_output":true,"text":"back-up.","text_display":" back-up.","confidence":1,"confidence_rate":1},{"cnt":[[339,937],[754,937],[754,982],[339,982]],"region":{"top_left_x":339,"top_left_y":936,"width":416,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26a444c8798b4c79a695b16ea2df30ad","type":"text","conversion_output":true,"text":"5.AST \\(<3 x\\) upper normal","text_display":"\n5.AST \\(<3 x\\) upper normal","confidence":0.5345968566834927,"confidence_rate":0.9812018893374702},{"cnt":[[339,982],[1760,982],[1760,1025],[339,1025]],"region":{"top_left_x":339,"top_left_y":981,"width":1421,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"610e1271a96541aea59da2d3678de97c","type":"text","conversion_output":true,"text":"6. Shortening fraction \\(\\geq 27 \\%\\), or ejection fraction \\(\\geq 50 \\%\\), no clinical congestive heart failure.","text_display":"\n6. Shortening fraction \\(\\geq 27 \\%\\), or ejection fraction \\(\\geq 50 \\%\\), no clinical congestive heart failure.","confidence":1,"confidence_rate":1},{"cnt":[[339,1021],[1884,1021],[1884,1070],[339,1070]],"region":{"top_left_x":339,"top_left_y":1020,"width":1546,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a75fa80f61e4bcf86d6fcecf9bd3786","type":"text","conversion_output":true,"text":"7. Creatinine clearance or GFR \\(\\geq 60 ml / min / 1.73 m^{2}\\) (If a creatinine clearance is performed at end of","text_display":"\n7. Creatinine clearance or GFR \\(\\geq 60 ml / min / 1.73 m^{2}\\) (If a creatinine clearance is performed at end of","confidence":0.735146209015511,"confidence_rate":0.9974603718489135},{"cnt":[[370,1066],[1880,1066],[1880,1115],[370,1115]],"region":{"top_left_x":369,"top_left_y":1065,"width":1511,"height":51},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24c7ea64d6154730b9ad92b76f98b307","type":"text","conversion_output":true,"text":"induction and the result is \\(<100 ml / min / 1.73 m^{2}\\), a GFR must be performed using a nuclear blood","text_display":" induction and the result is \\(<100 ml / min / 1.73 m^{2}\\), a GFR must be performed using a nuclear blood","confidence":1,"confidence_rate":1},{"cnt":[[370,1113],[1880,1113],[1880,1158],[370,1158]],"region":{"top_left_x":369,"top_left_y":1112,"width":1511,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df03392b9ea24ac190a57b55a4d1ff6e","type":"text","conversion_output":true,"text":"sampling method or iothalamate clearance method. Camera method is NOT allowed as measure","text_display":" sampling method or iothalamate clearance method. Camera method is NOT allowed as measure","confidence":1,"confidence_rate":1},{"cnt":[[370,1156],[1884,1156],[1884,1201],[370,1201]],"region":{"top_left_x":369,"top_left_y":1155,"width":1516,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef6a279b5df74d0e8c41c685b7653ace","type":"text","conversion_output":true,"text":"of GFR prior to or during Consolidation therapy for patients with GFR or creatinine clearance of","text_display":" of GFR prior to or during Consolidation therapy for patients with GFR or creatinine clearance of","confidence":1,"confidence_rate":1},{"cnt":[[370,1195],[728,1195],[728,1244],[370,1244]],"region":{"top_left_x":369,"top_left_y":1194,"width":360,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68bbc8f789df4834a5378d6e93b38228","type":"text","conversion_output":true,"text":"\\(<100 ml / min / 1.73 m^{2}\\).)","text_display":" \\(<100 ml / min / 1.73 m^{2}\\).)","confidence":0.99951171875,"confidence_rate":0.9999877900620892},{"cnt":[[120,1240],[2099,1240],[2099,2454],[120,2454]],"region":{"top_left_x":120,"top_left_y":1239,"width":1980,"height":1215},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d63a47ea0e884ba1a0dcced32d157d0a","type":"table","conversion_output":true,"children_ids":["474653a7596a4a8cae0537f73c59ee12","a9a93925f8b14224980adb4eae028dec","ce44a0a866694e3f9e2eb024c1075c08","3fff5f5305364a6eae45c5dbb0766d14","a5ada48bd0ce4420b5dcb13a5459746d","a9228d37a08e4522ba3ebfc5964625e1","df7f4e5aa91043ceb9f1c731442b880b","ff97dbb023554b378da75117d8309a04","d0b21ecba5ae482f887e0f488af14ae6","fce35db3be904bff9ee7f70cc0b53a5f","ac68d43cf2ba4769a1f68ca891ee2f21","5b8391a24476435d9c03e4514572c4f6","d438fc98964c4c6bbda29cfe3c189e4e","9e54a58b232641a4a45f9fad3c14e539","c84529a8110f481cb669e40cf75d6a80","b81c1903611140e58b52e106a42b279e","edf4f6857fa0406fa9abdad9aa8f6af8","74f4b3038d54479f83b4ae99ca29d42c","833f7b45946b4d61be84b0708d2c1a11","aa8f8ad3f8c140c680ee80476ecc85b7","bc0f60e58af04d428f71813b6ab7da25","812311d586f24ed9b373b2058bf3acfb","88c56e0f88924619b9eaa5757b55ce76","0309e72c88664052b701beb46116791b","cb891354a4424db0a925c9636a138bc7","44e57581ea3a499bb0816102a270a8a4","d50219fed851455e8a7382d53cadfa9a","634b6766a7bc41088f94e201762009e9","d934114ef45e493088ee83a8c12f4a3b","d37c1aa6dd16487893b8d6c99fb35c33","ab3efbfdd0754908bb68762ac32dde0c","017596ea4a294980aefcf91a2c327750","38890961c8ee42258ade2ca3624791f0","d6822b09f18a405897a13fd44c131ebc","dc6d7a706e0746ab80ae95ca4054ccd7","25646e467880455c94a24529261f4dbe"],"text":"\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline Thiotepa (TEPA) & IV over 2 hours & \\(300 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg , 10 mg / kg /\\) dose ) once daily x 3 doses. & Days -7, -6 and -5 & Thiotepa can cause significant skin toxicity with sloughing of skin. Bathe patient frequently in water only. Avoid large occlusive dressings, use of any skin creams and remove adhesive residue from prior dressings and leads. & \\multirow[t]{4}{*}{\\begin{tabular}{l}\na. Physical exam, ht, wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr, \\\\\nd. \\(Ca ^{++}, PO _{4}, Mg ^{++}\\) \\\\\ne. ALT, AST, bilirubin, albumin \\\\\nRefer to Protocol Section 7.0 for complete list of observations. \\\\\nOBTAIN OTHER STUDIES AS REQUIRED FOR GOOD PATIENT CARE\n\\end{tabular}} \\\\\n\\hline Cyclophosphamide (CPM) & IV over 1 hour & \\(1500 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg , 50 mg / kg /\\) dose ) once daily x 4 doses. & Days -5, -4, -3, and -2 & Suggest hydrating at 3000 \\(mL / m ^{2} /\\) day using fluid containing at least 0.45\\% NaCl. Suggest achieving urine specific gravity \\(\\leq\\) 1.010 prior to start of cyclophosphamide. & \\\\\n\\hline Mesna & IV over 15 minutes & \\(300 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg , 10 mg / kg /\\) dose ) immediately prior to each cyclophosphamide dose and then 4 hours and 8 hours after each cyclophosphamide dose & Days -5, -4, -3, and -2 & & \\\\\n\\hline Filgrastim (GCSF) & SubQ (or) IV (SubQ preferred) & 5 micrograms/kg once daily and continuing once daily until post-nadir ANC > \\(2000 / \\mu L\\) for 3 consecutive days. & Day 0 until ANC recovery & & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline Thiotepa (TEPA) & IV over 2 hours & \\(300 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg , 10 mg / kg /\\) dose ) once daily x 3 doses. & Days -7, -6 and -5 & Thiotepa can cause significant skin toxicity with sloughing of skin. Bathe patient frequently in water only. Avoid large occlusive dressings, use of any skin creams and remove adhesive residue from prior dressings and leads. & \\multirow[t]{4}{*}{\\begin{tabular}{l}\na. Physical exam, ht, wt \\\\\nb. CBC with diff and platelets \\\\\nc. Electrolytes, BUN, Cr, \\\\\nd. \\(Ca ^{++}, PO _{4}, Mg ^{++}\\) \\\\\ne. ALT, AST, bilirubin, albumin \\\\\nRefer to Protocol Section 7.0 for complete list of observations. \\\\\nOBTAIN OTHER STUDIES AS REQUIRED FOR GOOD PATIENT CARE\n\\end{tabular}} \\\\\n\\hline Cyclophosphamide (CPM) & IV over 1 hour & \\(1500 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg , 50 mg / kg /\\) dose ) once daily x 4 doses. & Days -5, -4, -3, and -2 & Suggest hydrating at 3000 \\(mL / m ^{2} /\\) day using fluid containing at least 0.45\\% NaCl. Suggest achieving urine specific gravity \\(\\leq\\) 1.010 prior to start of cyclophosphamide. & \\\\\n\\hline Mesna & IV over 15 minutes & \\(300 mg / m ^{2} /\\) dose (or if \\(\\leq 12 kg , 10 mg / kg /\\) dose ) immediately prior to each cyclophosphamide dose and then 4 hours and 8 hours after each cyclophosphamide dose & Days -5, -4, -3, and -2 & & \\\\\n\\hline Filgrastim (GCSF) & SubQ (or) IV (SubQ preferred) & 5 micrograms/kg once daily and continuing once daily until post-nadir ANC > \\(2000 / \\mu L\\) for 3 consecutive days. & Day 0 until ANC recovery & & 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No moderate or severe sinusoidal obstruction syndrome (SOS) (formerly veno-occlusive disease (VOD) ) during","confidence":0.92431640625,"confidence_rate":0.9993158790310103},{"cnt":[[339,1242],[518,1242],[518,1274],[339,1274]],"region":{"top_left_x":339,"top_left_y":1241,"width":179,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60ad8404ff4e488c94010b830716ee40","type":"text","conversion_output":true,"text":"HDC/SCR \\#1","text_display":" HDC/SCR \\#1","confidence":1,"confidence_rate":1},{"cnt":[[335,1272],[1096,1272],[1096,1317],[335,1317]],"region":{"top_left_x":335,"top_left_y":1271,"width":761,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48baf1f8cf0f4161989e617845c691fd","type":"section_header","conversion_output":false,"children_ids":["5d5f2913927f4d198cacdf4b2a3214cd"],"text":"","text_display":""},{"cnt":[[339,1276],[1091,1276],[1091,1315],[339,1315]],"region":{"top_left_x":339,"top_left_y":1276,"width":753,"height":39},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d5f2913927f4d198cacdf4b2a3214cd","type":"text","conversion_output":true,"parent_id":"48baf1f8cf0f4161989e617845c691fd","text":"Definition of sinusoidal obstruction syndrome (SOS)","text_display":"\n\n\\section*{Definition of sinusoidal obstruction syndrome (SOS)}","confidence":1,"confidence_rate":1},{"cnt":[[339,1315],[1878,1315],[1878,1354],[339,1354]],"region":{"top_left_x":339,"top_left_y":1314,"width":1539,"height":40},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e2d2c0af3644b62a1f727eecf6954af","type":"text","conversion_output":true,"text":"SOS (formerly known as VOD) is a syndrome of hepatic dysfunction, which develops by Day+21 post stem cell","text_display":"\n\nSOS (formerly known as VOD) is a syndrome of hepatic dysfunction, which develops by Day+21 post stem cell","confidence":0.6836903095245361,"confidence_rate":0.9965491476722749},{"cnt":[[339,1354],[1876,1354],[1876,1392],[339,1392]],"region":{"top_left_x":339,"top_left_y":1353,"width":1537,"height":40},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90e508dc026f49c083ff89169996768f","type":"text","conversion_output":true,"text":"transplant, and is characterized by hyperbilirubinemia \\(\\geq 2 mg / dL\\), with at least two of the following three findings:","text_display":" transplant, and is characterized by hyperbilirubinemia \\(\\geq 2 mg / dL\\), with at least two of the following three findings:","confidence":1,"confidence_rate":1},{"cnt":[[339,1392],[1880,1392],[1880,1429],[339,1429]],"region":{"top_left_x":339,"top_left_y":1392,"width":1541,"height":37},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96048e274aad44dcbe47b8c018d35ec2","type":"text","conversion_output":true,"text":"ascites, hepatomegaly, which is usually painful, and weight gain \\(>5 \\%\\) over baseline. Patients with SOS during SCT","text_display":" ascites, hepatomegaly, which is usually painful, and weight gain \\(>5 \\%\\) over baseline. Patients with SOS during SCT","confidence":0.9799900054931641,"confidence_rate":0.9998315733033198},{"cnt":[[339,1429],[1878,1429],[1878,1467],[339,1467]],"region":{"top_left_x":339,"top_left_y":1428,"width":1539,"height":40},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d254ba75a7946979545ff49530c0ca3","type":"text","conversion_output":true,"text":"\\#1, with hepatic function meeting eligibility for SCT\\#2 and NOT meeting definitions for moderate or severe SOS","text_display":" \\#1, with hepatic function meeting eligibility for SCT\\#2 and NOT meeting definitions for moderate or severe SOS","confidence":1,"confidence_rate":1},{"cnt":[[339,1465],[827,1465],[827,1506],[339,1506]],"region":{"top_left_x":339,"top_left_y":1465,"width":489,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"383813ff24bf434d8aa5924bea362994","type":"text","conversion_output":true,"text":"(see below), may proceed to SCT\\#2.","text_display":" (see below), may proceed to SCT\\#2.","confidence":1,"confidence_rate":1},{"cnt":[[335,1519],[703,1519],[703,1566],[335,1566]],"region":{"top_left_x":335,"top_left_y":1518,"width":368,"height":49},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b92c5365d140459fbdf4d69be9b806ee","type":"section_header","conversion_output":false,"children_ids":["6232aa988d424e50ac4190d5173b7047"],"text":"","text_display":""},{"cnt":[[339,1525],[698,1525],[698,1562],[339,1562]],"region":{"top_left_x":339,"top_left_y":1525,"width":360,"height":37},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6232aa988d424e50ac4190d5173b7047","type":"text","conversion_output":true,"parent_id":"b92c5365d140459fbdf4d69be9b806ee","text":"Definition of severe SOS:","text_display":"\n\n\\section*{Definition of severe SOS:}","confidence":1,"confidence_rate":1},{"cnt":[[346,1560],[1880,1560],[1880,1601],[346,1601]],"region":{"top_left_x":345,"top_left_y":1559,"width":1535,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78c4ce9bf89d42468af9bb33bf644ccf","type":"text","conversion_output":true,"text":"Severe SOS is defined as a SOS episode accompanied by specific organ failure (hepatic encephalopathy (CTC","text_display":"\n\nSevere SOS is defined as a SOS episode accompanied by specific organ failure (hepatic encephalopathy (CTC","confidence":1,"confidence_rate":1},{"cnt":[[339,1601],[1880,1601],[1880,1639],[339,1639]],"region":{"top_left_x":339,"top_left_y":1600,"width":1541,"height":40},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd1ebc06ce8e4f57aae8d8aa03d6081f","type":"text","conversion_output":true,"text":"Grade 4 liver dysfunction/failure, clinical will be referred as \"Hepatic failure\" per CTCAE v.4.0 followed starting","text_display":" Grade 4 liver dysfunction/failure, clinical will be referred as \"Hepatic failure\" per CTCAE v.4.0 followed starting","confidence":1,"confidence_rate":1},{"cnt":[[339,1637],[1880,1637],[1880,1682],[339,1682]],"region":{"top_left_x":339,"top_left_y":1637,"width":1541,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a37892ca3c044d5b6fa4a6dea272947","type":"text","conversion_output":true,"text":"July \\(1^{\\text {st }}\\), 2011), continuous oxygen requirement (CTC Grade 3 hypoxia), serum creatinine \\(>3\\) times the upper limit","text_display":" July \\(1^{\\text {st }}\\), 2011), continuous oxygen requirement (CTC Grade 3 hypoxia), serum creatinine \\(>3\\) times the upper limit","confidence":0.9912109375,"confidence_rate":0.9999360316538621},{"cnt":[[339,1680],[1880,1680],[1880,1721],[339,1721]],"region":{"top_left_x":339,"top_left_y":1680,"width":1541,"height":41},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cd15c00a45b432e8c3cf443151661ae","type":"text","conversion_output":true,"text":"of normal (CTC Grade 3 creatinine), requirement for ventilatory support or dialysis not clearly attributable to","text_display":" of normal (CTC Grade 3 creatinine), requirement for ventilatory support or dialysis not clearly attributable to","confidence":1,"confidence_rate":1},{"cnt":[[339,1719],[1644,1719],[1644,1760],[339,1760]],"region":{"top_left_x":339,"top_left_y":1718,"width":1305,"height":42},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"359c36e811bb48fdbbc1e4ff61d52f2a","type":"text","conversion_output":true,"text":"another cause. Patients with a history of severe SOS, even if resolved, should not undergo SCT\\#2.","text_display":" another cause. Patients with a history of severe SOS, even if resolved, should not undergo SCT\\#2.","confidence":1,"confidence_rate":1},{"cnt":[[335,1775],[746,1775],[746,1820],[335,1820]],"region":{"top_left_x":335,"top_left_y":1774,"width":411,"height":46},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5becd213c8784bedb3e2f0ca8529b988","type":"section_header","conversion_output":false,"children_ids":["7551a806df2e484c8c14544b6d0f397c"],"text":"","text_display":""},{"cnt":[[339,1779],[746,1779],[746,1815],[339,1815]],"region":{"top_left_x":339,"top_left_y":1778,"width":407,"height":38},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7551a806df2e484c8c14544b6d0f397c","type":"text","conversion_output":true,"parent_id":"5becd213c8784bedb3e2f0ca8529b988","text":"Definition of moderate SOS:","text_display":"\n\n\\section*{Definition of moderate SOS:}","confidence":1,"confidence_rate":1},{"cnt":[[344,1818],[1880,1818],[1880,1854],[344,1854]],"region":{"top_left_x":343,"top_left_y":1817,"width":1537,"height":38},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3cb8a64e5fed419785a93604eea775a3","type":"text","conversion_output":true,"text":"Moderate SOS is defined as a SOS episode where the peak total bilirubin was \\(10 mg / dL\\) or greater (personal","text_display":"\n\nModerate SOS is defined as a SOS episode where the peak total bilirubin was \\(10 mg / dL\\) or greater (personal","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[339,1852],[1880,1852],[1880,1893],[339,1893]],"region":{"top_left_x":339,"top_left_y":1851,"width":1541,"height":42},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"423eaab0813044de9fda3bbdd80214ce","type":"text","conversion_output":true,"text":"communication, Paul Richardson). 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Minimum frozen PBSC of \\(2 \\times 10^{6} CD 34\\) cells \\(/ kg\\) is mandatory to proceed with second transplant.","text_display":"\n7. Minimum frozen PBSC of \\(2 \\times 10^{6} CD 34\\) cells \\(/ kg\\) is mandatory to proceed with second transplant.","confidence":0.96142578125,"confidence_rate":0.9996638350842942},{"cnt":[[277,1987],[1880,1987],[1880,2026],[277,2026]],"region":{"top_left_x":277,"top_left_y":1987,"width":1603,"height":39},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b0d97bdb465455fa8058b5285ee508f","type":"text","conversion_output":true,"text":"8. No clinical evidence of disease progression defined as increase in tumor size by \\(25 \\%\\) or new lesions; restaging","text_display":"\n8. 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dosing:","confidence":0.99951171875,"confidence_rate":0.9999891467144949},{"cnt":[[262,1818],[1824,1818],[1824,1867],[262,1867]],"region":{"top_left_x":262,"top_left_y":1817,"width":1563,"height":50},"line":134,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"424022bc398f43b9a4f1d0ea2def1183","type":"text","conversion_output":true,"text":"Patients with GFR \\(<100 ml / min / 1.73 m^{2}\\) who are \\(>12 kg\\) will be dosed according to the formula below to","text_display":"\nPatients with GFR \\(<100 ml / min / 1.73 m^{2}\\) who are \\(>12 kg\\) will be dosed according to the formula below to","confidence":0.9834539657458663,"confidence_rate":0.999868635016451},{"cnt":[[245,1865],[1227,1865],[1227,1906],[245,1906]],"region":{"top_left_x":244,"top_left_y":1864,"width":983,"height":42},"line":135,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ee8dd9fdab84180ab3471be38e5ddd2","type":"text","conversion_output":true,"text":"achieve an area under the concentration versus time curve (AUC)","text_display":" achieve an area under the concentration versus time curve (AUC)","confidence":0.9990234375,"confidence_rate":0.9999856318731074},{"cnt":[[260,1904],[1833,1904],[1833,1946],[260,1946]],"region":{"top_left_x":259,"top_left_y":1903,"width":1574,"height":44},"line":136,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61f10c65d2fa47b7987b52d8ca75cd19","type":"text","conversion_output":true,"text":"of 4.1 per dose. GFR will be calculated using a blood sampling method. Daily dose should not exceed 300","text_display":"\nof 4.1 per dose. GFR will be calculated using a blood sampling method. Daily dose should not exceed 300","confidence":0.98046875,"confidence_rate":0.9998207023907582},{"cnt":[[245,1938],[359,1938],[359,1987],[245,1987]],"region":{"top_left_x":244,"top_left_y":1937,"width":115,"height":51},"line":137,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef41dd474342409dbd1519ef11e5773c","type":"text","conversion_output":true,"text":"\\(mg / m ^{2}\\).","text_display":" \\(mg / m ^{2}\\).","confidence":0.99755859375,"confidence_rate":0.9998981555472577},{"cnt":[[228,2020],[1953,2020],[1953,2142],[228,2142]],"region":{"top_left_x":227,"top_left_y":2019,"width":1726,"height":123},"line":138,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae31a39ced024d3289980c2f2b539b58","type":"text","conversion_output":true,"text":"Total Dose \\(( mg ) / day =\\left\\{\\frac{(\\text { Corrected GFR } x \\text { surface area })}{1.73}+(15 x \\text { surface area })\\right\\}^{\\times 4.1}\\)","text_display":"\n\nTotal Dose \\(( mg 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mg\\)","confidence":0.9428194478132355,"confidence_rate":0.999505328437281},{"cnt":[[825,2273],[889,2273],[889,2307],[825,2307]],"region":{"top_left_x":825,"top_left_y":2273,"width":65,"height":35},"line":141,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d99b13707db64b39ae2c19e685fdc25d","type":"text","conversion_output":true,"text":"1.73","text_display":" 1.73","confidence":1,"confidence_rate":1},{"cnt":[[370,2303],[1880,2303],[1880,2348],[370,2348]],"region":{"top_left_x":369,"top_left_y":2303,"width":1511,"height":46},"line":142,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb7876a005d540b28450db3c9e60933e","type":"text","conversion_output":true,"text":"NOTE: if lab reports raw GFR in \\(mL / min\\) instead of corrected GFR in \\(mL / min / 1.73 m^{2}\\), convert Raw GFR to corrected","text_display":"\n\nNOTE: if lab reports raw GFR in \\(mL / min\\) instead of corrected GFR in \\(mL / min / 1.73 m^{2}\\), convert Raw GFR to 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DRUG & ROUTE & DOSAGE & DAYS & IMPORTANT NOTES & OBSERVATIONS \\\\\n\\hline Melphalan (MEL) & IV over 15-30 minutes & \\(2 mg / kg /\\) dose once daily x 3 doses. . & Days -7, -6 and -5 & Must be infused within 1 hour of preparation. & \\\\\n\\hline Etoposide (ETOP) & IV over 24 hours & \\(6.7 mg / kg /\\) dose once daily x 4 doses. & Days -7, -6, -5 and -4 & & \\\\\n\\hline CARBOplatin (CARB) & IV over 24 hours & See Calvert Formula* below for dose calculation; give dose once daily x 4 doses. . 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If patient is due to begin next cycle of cyclophosphamide","text_display":" hematuria resolves to Grade 2 or less. 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Make notation of substitution on data forms. The intent of Induction is to give a total of 2 cycles","text_display":" cycle. Make notation of substitution on data forms. 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If the same Grade 3","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1878,425],[1878,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1634,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fd1bc464a69401eae9d6a53f7dadb08","type":"text","conversion_output":true,"text":"or 4 toxicity recurs at a \\(25 \\%\\) dose reduction, then decrease dose another \\(20 \\%\\) (to \\(100 mg / m ^{2} /\\) day 3.33","text_display":" or 4 toxicity recurs at a \\(25 \\%\\) dose reduction, then decrease dose another \\(20 \\%\\) (to \\(100 mg / m ^{2} /\\) day 3.33","confidence":0.5544224999277958,"confidence_rate":0.9954025675111553},{"cnt":[[245,473],[1878,473],[1878,520],[245,520]],"region":{"top_left_x":244,"top_left_y":472,"width":1634,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5fec5ba2f914f1885c2db6169d45e31","type":"text","conversion_output":true,"text":"\\(mg / kg /\\) day if child weighs \\(\\leq 12 kg\\). If the same Grade 3 or 4 toxicity recurs after two dose reductions,","text_display":" \\(mg / kg /\\) day if child weighs \\(\\leq 12 kg\\). If the same Grade 3 or 4 toxicity recurs after two dose reductions,","confidence":0.4865908622741699,"confidence_rate":0.9942077143191225},{"cnt":[[245,520],[1613,520],[1613,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":1370,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"024f101b81f44cddb857b723fc1c43d1","type":"text","conversion_output":true,"text":"and toxicity cannot be attributed to an alternative etiology, then withhold further therapy.","text_display":" and toxicity cannot be attributed to an alternative etiology, then withhold further therapy.","confidence":1,"confidence_rate":1},{"cnt":[[241,604],[352,604],[352,647],[241,647]],"region":{"top_left_x":240,"top_left_y":603,"width":113,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3911774bec24d99bced38e709c5ea1e","type":"section_header","conversion_output":false,"children_ids":["a8069f41080a4b018f1a57fd2193bf2b"],"text":"","text_display":""},{"cnt":[[245,610],[350,610],[350,642],[245,642]],"region":{"top_left_x":244,"top_left_y":610,"width":107,"height":33},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8069f41080a4b018f1a57fd2193bf2b","type":"text","conversion_output":true,"parent_id":"d3911774bec24d99bced38e709c5ea1e","text":"5.11.2","text_display":"\n\n\\subsection*{5.11.2}","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1880,649],[1880,696],[245,696]],"region":{"top_left_x":244,"top_left_y":648,"width":1636,"height":49},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97a74692be84467aa236c3cc212e212b","type":"text","conversion_output":true,"text":"It has been reported (rarely) that some patients treated with cis-RA develop new areas of abnormal uptake","text_display":"\n\nIt has been reported (rarely) that some patients treated with cis-RA develop new areas of abnormal uptake","confidence":1,"confidence_rate":1},{"cnt":[[245,696],[1880,696],[1880,741],[245,741]],"region":{"top_left_x":244,"top_left_y":696,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e89f105b0a2e4cff88aefc60545ce12c","type":"text","conversion_output":true,"text":"on bone scan, likely due to increased bone resorption. If such changes occur during retinoic acid phase in","text_display":" on bone scan, likely due to increased bone resorption. If such changes occur during retinoic acid phase in","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[1523,739],[1523,784],[245,784]],"region":{"top_left_x":244,"top_left_y":739,"width":1280,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bdd7e4672ad24d05a3c2017c94abe76c","type":"text","conversion_output":true,"text":"absence of other evidence of tumor recurrence do not report as progressive disease.","text_display":" absence of other evidence of tumor recurrence do not report as progressive disease.","confidence":0.99462890625,"confidence_rate":0.999938802214336},{"cnt":[[245,825],[350,825],[350,866],[245,866]],"region":{"top_left_x":244,"top_left_y":825,"width":107,"height":41},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07ee607281ea4d22853a67c3ea8410a0","type":"section_header","conversion_output":false,"children_ids":["6b1c6984b020485289a7588680aedfb8"],"text":"","text_display":""},{"cnt":[[247,829],[346,829],[346,864],[247,864]],"region":{"top_left_x":247,"top_left_y":829,"width":99,"height":35},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b1c6984b020485289a7588680aedfb8","type":"text","conversion_output":true,"parent_id":"07ee607281ea4d22853a67c3ea8410a0","text":"5.11.3","text_display":"\n\n\\subsection*{5.11.3}","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1880,868],[1880,915],[245,915]],"region":{"top_left_x":244,"top_left_y":867,"width":1636,"height":49},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfaaf36484f645eda709b670210fbb88","type":"text","conversion_output":true,"text":"If criteria (Section 4.8.1) to begin next cycle are not met by the date cycle is due to begin, delay cycle for","text_display":"\n\nIf criteria (Section 4.8.1) to begin next cycle are not met by the date cycle is due to begin, delay cycle for","confidence":1,"confidence_rate":1},{"cnt":[[245,915],[1880,915],[1880,958],[245,958]],"region":{"top_left_x":244,"top_left_y":915,"width":1636,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9fbeedea12c443b8756bbf78001d300","type":"text","conversion_output":true,"text":"one week. If criteria still not met, hold therapy until criteria are met, and treat at \\(25 \\%\\) dose reduction ( 120","text_display":" one week. If criteria still not met, hold therapy until criteria are met, and treat at \\(25 \\%\\) dose reduction ( 120","confidence":0.99658203125,"confidence_rate":0.9999709849688293},{"cnt":[[245,958],[1880,958],[1880,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":958,"width":1636,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d1cd1431f9f4fdeb01304866991ee52","type":"text","conversion_output":true,"text":"\\(mg / m ^{2} /\\) day or \\(4 mg / kg /\\) day if child weighs \\(\\leq 12 kg\\) ). An additional dose reduction to \\(100 mg / m ^{2} /\\) day ( 3.33","text_display":" \\(mg / m ^{2} /\\) day or \\(4 mg / kg /\\) day if child weighs \\(\\leq 12 kg\\) ). An additional dose reduction to \\(100 mg / m ^{2} /\\) day ( 3.33","confidence":0.6465868963296606,"confidence_rate":0.9971725264166758},{"cnt":[[245,1008],[1880,1008],[1880,1053],[245,1053]],"region":{"top_left_x":244,"top_left_y":1007,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"499cc445f7b448d5aab9f1363eb68ef8","type":"text","conversion_output":true,"text":"\\(mg / kg /\\) day if child weighs \\(\\leq 12 kg\\) ) should occur if criteria are not met within one week after due date for","text_display":" \\(mg / kg /\\) day if child weighs \\(\\leq 12 kg\\) ) should occur if criteria are not met within one week after due date for","confidence":0.9956102357245982,"confidence_rate":0.9999639397683766},{"cnt":[[245,1053],[535,1053],[535,1098],[245,1098]],"region":{"top_left_x":244,"top_left_y":1052,"width":291,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"041a9863140242aa87f7711f4514cb71","type":"text","conversion_output":true,"text":"subsequent cycles.","text_display":" subsequent cycles.","confidence":1,"confidence_rate":1},{"cnt":[[243,1139],[350,1139],[350,1179],[243,1179]],"region":{"top_left_x":242,"top_left_y":1138,"width":109,"height":42},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f79a272a1fb2410982ee37f6fdb6cdb3","type":"section_header","conversion_output":false,"children_ids":["cc806f4b7655486aa3515c4a4391fef7"],"text":"","text_display":""},{"cnt":[[245,1143],[350,1143],[350,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1142,"width":107,"height":34},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc806f4b7655486aa3515c4a4391fef7","type":"text","conversion_output":true,"parent_id":"f79a272a1fb2410982ee37f6fdb6cdb3","text":"5.11.4","text_display":"\n\n\\subsection*{5.11.4}","confidence":1,"confidence_rate":1},{"cnt":[[245,1182],[1878,1182],[1878,1227],[245,1227]],"region":{"top_left_x":244,"top_left_y":1181,"width":1634,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9b72f939ff74b6299f829da222a58a6","type":"text","conversion_output":true,"text":"If serum creatinine increases by \\(>50 \\%\\) in any cycle of therapy, creatinine clearance or GFR should be","text_display":"\n\nIf serum creatinine increases by \\(>50 \\%\\) in any cycle of therapy, creatinine clearance or GFR should be","confidence":1,"confidence_rate":1},{"cnt":[[245,1227],[1880,1227],[1880,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1226,"width":1636,"height":49},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0a7dcd347b9446e8d31bb2fcb992c96","type":"text","conversion_output":true,"text":"done prior to starting next cycle, and a urinalysis. If creatinine clearance and/or GFR are \\(<50\\)","text_display":" done prior to starting next cycle, and a urinalysis. If creatinine clearance and/or GFR are \\(<50","confidence":0.7550131506286561,"confidence_rate":0.9971654379905085},{"cnt":[[245,1272],[1880,1272],[1880,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1271,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c37e67f48db944f1b6ba61a41115e872","type":"text","conversion_output":true,"text":"\\(mL / min / 1.73 m^{2}\\) reduce cis-RA by \\(50 \\%\\). If serum creatinine continues to increase or GFR decreased to \\(<\\)","text_display":" mL / min / 1.73 m^{2}\\) reduce cis-RA by \\(50 \\%\\). If serum creatinine continues to increase or GFR decreased to \\(<","confidence":0.9324078593635932,"confidence_rate":0.9994265174328749},{"cnt":[[245,1315],[1018,1315],[1018,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1314,"width":775,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79756a742e6249dfa85c6c4f50ed69e3","type":"text","conversion_output":true,"text":"\\(40 mL / min / 1.73 m^{2}\\) then withhold further therapy.","text_display":" 40 mL / min / 1.73 m^{2}\\) then withhold further therapy.","confidence":0.69921875,"confidence_rate":0.9945935821330391},{"cnt":[[243,1401],[350,1401],[350,1446],[243,1446]],"region":{"top_left_x":242,"top_left_y":1400,"width":109,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61e896e16c524e918e35671fab5843da","type":"section_header","conversion_output":false,"children_ids":["001ea61f4fa540818612d1cf93b4b025"],"text":"","text_display":""},{"cnt":[[245,1405],[346,1405],[346,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1405,"width":102,"height":37},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"001ea61f4fa540818612d1cf93b4b025","type":"text","conversion_output":true,"parent_id":"61e896e16c524e918e35671fab5843da","text":"5.11.5","text_display":"\n\n\\subsection*{5.11.5}","confidence":1,"confidence_rate":1},{"cnt":[[245,1448],[1876,1448],[1876,1493],[245,1493]],"region":{"top_left_x":244,"top_left_y":1448,"width":1632,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed606c1a3fdc4c7288c72ecf12cf5051","type":"text","conversion_output":true,"text":"If patient > Grade 1 develops hematuria, proteinuria, and/or hypertension during any cycle of therapy,","text_display":"\n\nIf patient > Grade 1 develops hematuria, proteinuria, and/or hypertension during any cycle of therapy,","confidence":0.5615234375,"confidence_rate":0.9947673585340585},{"cnt":[[245,1491],[1435,1491],[1435,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1491,"width":1192,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"831cb5241b3649bf96249ac5149143b5","type":"text","conversion_output":true,"text":"hold medication until resolves to \\(\\leq\\) Grade 1 then reduce cis-RA dose by \\(25 \\%\\).","text_display":" hold medication until resolves to \\(\\leq\\) Grade 1 then reduce cis-RA dose by \\(25 \\%\\).","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[350,1577],[350,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1576,"width":107,"height":42},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96b3c47d3e0347c0ba9d154c6cb28f3c","type":"section_header","conversion_output":false,"children_ids":["e9fc43ebe23e4c43a683e8c185f372f5"],"text":"","text_display":""},{"cnt":[[247,1581],[350,1581],[350,1618],[247,1618]],"region":{"top_left_x":247,"top_left_y":1581,"width":104,"height":37},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9fc43ebe23e4c43a683e8c185f372f5","type":"text","conversion_output":true,"parent_id":"96b3c47d3e0347c0ba9d154c6cb28f3c","text":"5.11.6","text_display":"\n\n\\subsection*{5.11.6}","confidence":1,"confidence_rate":1},{"cnt":[[247,1624],[1880,1624],[1880,1669],[247,1669]],"region":{"top_left_x":247,"top_left_y":1624,"width":1633,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"214b803ae42548d1bd4e3c239a9f7556","type":"text","conversion_output":true,"text":"For localized cheilitis, apply topical vitamin E to lips for subsequent cycles. If this does not control","text_display":"\n\nFor localized cheilitis, apply topical vitamin E to lips for subsequent cycles. If this does not control","confidence":0.499755859375,"confidence_rate":0.9939865399169032},{"cnt":[[245,1667],[1880,1667],[1880,1712],[245,1712]],"region":{"top_left_x":244,"top_left_y":1667,"width":1636,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2a9bff4754d445a8577b4645cf153bd","type":"text","conversion_output":true,"text":"symptoms sufficiently to allow sufficient oral intake, then decrease dose by \\(25 \\%\\left(120 mg / m ^{2} /\\right.\\) day or 4","text_display":" symptoms sufficiently to allow sufficient oral intake, then decrease dose by \\(25 \\%\\left(120 mg / m ^{2} /\\right.\\) day or 4","confidence":0.6970725059509277,"confidence_rate":0.9970704309049561},{"cnt":[[245,1714],[801,1714],[801,1760],[245,1760]],"region":{"top_left_x":244,"top_left_y":1714,"width":558,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33737469158b47f0887cdd072be05920","type":"text","conversion_output":true,"text":"\\(mg / kg /\\) day if child weighs \\(\\leq 12 kg\\) ).","text_display":" \\(mg / kg /\\) day if child weighs \\(\\leq 12 kg\\) ).","confidence":0.8940577507019043,"confidence_rate":0.9979659821909495},{"cnt":[[243,1800],[350,1800],[350,1841],[243,1841]],"region":{"top_left_x":242,"top_left_y":1800,"width":109,"height":42},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6735414cfa8b470c9e9fd588d1990209","type":"section_header","conversion_output":false,"children_ids":["67105279f2a74d2a924758a0fce792cc"],"text":"","text_display":""},{"cnt":[[245,1805],[346,1805],[346,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1804,"width":102,"height":38},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67105279f2a74d2a924758a0fce792cc","type":"text","conversion_output":true,"parent_id":"6735414cfa8b470c9e9fd588d1990209","text":"5.11.7","text_display":"\n\n\\subsection*{5.11.7}","confidence":1,"confidence_rate":1},{"cnt":[[245,1843],[1884,1843],[1884,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1843,"width":1641,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cae525c2f4a74c5f8a7125d01b6dafc7","type":"text","conversion_output":true,"text":"If serum triglycerides are \\(>300 mg / dL\\) when next cycle is due, delay starting therapy for two weeks. If","text_display":"\n\nIf serum triglycerides are \\(>300 mg / dL\\) when next cycle is due, delay starting therapy for two weeks. If","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,1891],[1880,1891],[1880,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1890,"width":1636,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6365507b8ad84f3c98dd3ac1d6917a5c","type":"text","conversion_output":true,"text":"still \\(>300 mg / dL\\), then start patient on medical therapy for serum triglyceride reduction (consider","text_display":" still \\(>300 mg / dL\\), then start patient on medical therapy for serum triglyceride reduction (consider","confidence":0.99853515625,"confidence_rate":0.9999869115349181},{"cnt":[[245,1934],[1880,1934],[1880,1979],[245,1979]],"region":{"top_left_x":244,"top_left_y":1933,"width":1636,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a007e447c3284f678ad3682a068287af","type":"text","conversion_output":true,"text":"cardiology consultation) and begin cycle at previous cis-RA dosage. If serum triglycerides are < 300","text_display":" cardiology consultation) and begin cycle at previous cis-RA dosage. If serum triglycerides are < 300","confidence":0.6539525985717773,"confidence_rate":0.9959244774853511},{"cnt":[[245,1977],[1880,1977],[1880,2022],[245,2022]],"region":{"top_left_x":244,"top_left_y":1976,"width":1636,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6a6cd0d838c4056ace5ffed9cfb5a76","type":"text","conversion_output":true,"text":"\\(mg / dL\\) by time subsequent cycle is due, then continue at same dosage cis-RA. If triglycerides are still >","text_display":" \\(mg / dL\\) by time subsequent cycle is due, then continue at same dosage cis-RA. If triglycerides are still >","confidence":0.96044921875,"confidence_rate":0.9996460787171086},{"cnt":[[245,2020],[1880,2020],[1880,2067],[245,2067]],"region":{"top_left_x":244,"top_left_y":2019,"width":1636,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"350b7e346fa64f8e89a8d1785ec03d2c","type":"text","conversion_output":true,"text":"\\(300 mg / dL\\) after one cycle on medical therapy, then reduce cis-RA acid dosage by \\(25 \\%\\) for subsequent","text_display":" \\(300 mg / dL\\) after one cycle on medical therapy, then reduce cis-RA acid dosage by \\(25 \\%\\) for subsequent","confidence":1,"confidence_rate":1},{"cnt":[[245,2067],[357,2067],[357,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2066,"width":113,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a9acf82bf004ab299e11c87c82a5e10","type":"text","conversion_output":true,"text":"cycles.","text_display":" cycles.","confidence":1,"confidence_rate":1},{"cnt":[[245,2157],[786,2157],[786,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2157,"width":543,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab9fd1795e814845924e14b5e19817b2","type":"section_header","conversion_output":false,"children_ids":["0ff3ea4efd5245478871f0137453ba0d"],"text":"","text_display":""},{"cnt":[[249,2161],[784,2161],[784,2198],[249,2198]],"region":{"top_left_x":249,"top_left_y":2161,"width":536,"height":37},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ff3ea4efd5245478871f0137453ba0d","type":"text","conversion_output":true,"parent_id":"ab9fd1795e814845924e14b5e19817b2","text":"6.0 DRUG INFORMATION","text_display":"\n\n\\subsection*{6.0 DRUG INFORMATION}","confidence":0.99951171875,"confidence_rate":0.9999804641709025},{"cnt":[[335,2247],[1880,2247],[1880,2292],[335,2292]],"region":{"top_left_x":335,"top_left_y":2247,"width":1545,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38586a9434c24077a818c059b64ec45c","type":"text","conversion_output":true,"text":"See the consent document for toxicities. All other information is available on the COG website in","text_display":"\n\nSee the consent document for toxicities. All other information is available on the COG website in","confidence":1,"confidence_rate":1},{"cnt":[[335,2299],[1880,2299],[1880,2346],[335,2346]],"region":{"top_left_x":335,"top_left_y":2298,"width":1545,"height":49},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"308d24e770584b2f80496af8e1a3c096","type":"text","conversion_output":true,"text":"the manual titled \"Drug Information for Commercial Agents used by the Children's Oncology","text_display":" the manual titled \"Drug Information for Commercial Agents used by the Children's Oncology","confidence":0.99853515625,"confidence_rate":0.9999844052526365},{"cnt":[[335,2346],[1880,2346],[1880,2396],[335,2396]],"region":{"top_left_x":335,"top_left_y":2346,"width":1545,"height":50},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f6a6d468f3140d88a574ffd908e4491","type":"text","conversion_output":true,"text":"Group\" at: 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Observation & Pre-Treatment & Prior to Each Cycle & During Cycle 1, 2 & Following Cycle 2 & At PBSC Harvest & Prior to Surgery & End of Induction & At Relapse \\\\\n\\hline Physical Exam & X & X & & & & & X & \\\\\n\\hline Height, Weight & X & X & & & & & X & \\\\\n\\hline CBC with diff/platelets & X & \\(X ^{1}\\) & & & & & X & \\\\\n\\hline Electrolytes, BUN, Cr., Ca, Phos, Mg & X & \\(X ^{2}\\) & & & & & X & \\\\\n\\hline ALT, AST, Bilirubin, Urinalysis, albumin \\({ }^{3}\\) & X & X & & & & & X & \\\\\n\\hline ECG and MUGA or ECHO & X & & & & & & X & \\\\\n\\hline GFR or Creatinine Clearance \\({ }^{4}\\) & X & & & & & & \\(X ^{4}\\) & \\\\\n\\hline Audiogram or BAERs & X & & & & & & X & \\\\\n\\hline Bilateral BM Asp/Bx & X & & & \\(X ^{5}\\) & & & X & \\(X ^{6}\\) \\\\\n\\hline BM PCR & \\(X ^{7}\\) & & & \\(X ^{7}\\) & & & \\(X ^{7}\\) & \\\\\n\\hline BM ICC & \\(X ^{7}\\) & & & & & & \\(X ^{7}\\) & \\\\\n\\hline Peripheral Blood PCR & \\(X ^{8}\\) & & & & & & \\(X ^{8}\\) & 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DO NOT NEED results to proceed to PBSC collection).","text_display":" patient is undergoing anesthesia for apheresis line placement. DO NOT NEED results to proceed to PBSC collection).","confidence":1,"confidence_rate":1},{"cnt":[[372,400],[1772,400],[1772,436],[372,436]],"region":{"top_left_x":371,"top_left_y":399,"width":1402,"height":38},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b8a770f43634ccd8f5fd6a8e7061cff","type":"text","conversion_output":true,"text":"Send bone marrow and if biopsy performed, send sample of fresh and snap frozen tumor. Ship per ANBL00B1","text_display":" Send bone marrow and if biopsy performed, send sample of fresh and snap frozen tumor. 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Following","confidence":0.9960999437631125,"confidence_rate":0.9999697083557927},{"cnt":[[374,507],[1742,507],[1742,544],[374,544]],"region":{"top_left_x":373,"top_left_y":507,"width":1370,"height":37},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b528dfe40345498a89e6d783dd04edb4","type":"text","conversion_output":true,"text":"cycle 2 obtain 0.5 cc from a single BM site for PCR only. See Section 15.4 for details regarding bone marrow","text_display":" cycle 2 obtain 0.5 cc from a single BM site for PCR only. See Section 15.4 for details regarding bone marrow","confidence":0.9699363708496094,"confidence_rate":0.9997538625008497},{"cnt":[[374,544],[900,544],[900,578],[374,578]],"region":{"top_left_x":373,"top_left_y":543,"width":528,"height":35},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"890420e678e5424f94d2cbe56d53f4e9","type":"text","conversion_output":true,"text":"immunocytochemistry and PCR analyses.","text_display":" immunocytochemistry and PCR analyses.","confidence":1,"confidence_rate":1},{"cnt":[[372,580],[1540,580],[1540,617],[372,617]],"region":{"top_left_x":371,"top_left_y":580,"width":1170,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5bdbb5bafd944b1a76d5cf40158c017","type":"text","conversion_output":true,"text":"Obtain 2 mL peripheral blood in sodium heparin or EDTA tube. See section 15.6 for details.","text_display":"\nObtain 2 mL peripheral blood in sodium heparin or EDTA tube. 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See Section 15.8 for details","confidence":0.916015625,"confidence_rate":0.999335661251124},{"cnt":[[372,649],[1790,649],[1790,690],[372,690]],"region":{"top_left_x":371,"top_left_y":648,"width":1419,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c977e62c6ecd4e1d80344246e056ad42","type":"text","conversion_output":true,"text":"Collect 2 cc in green top tube 15 minutes after completion of topotecan infusion on day 1 of Cycles 1 and 2. See","text_display":" Collect 2 cc in green top tube 15 minutes after completion of topotecan infusion on day 1 of Cycles 1 and 2. See","confidence":0.7288292655721307,"confidence_rate":0.9975509435495032},{"cnt":[[372,688],[1145,688],[1145,724],[372,724]],"region":{"top_left_x":371,"top_left_y":687,"width":775,"height":38},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8536b135f8b440f88ba0329687902f0c","type":"text","conversion_output":true,"text":"Section 15.3 for details and ordering of sample collection kit.","text_display":" Section 15.3 for details and ordering of sample collection kit.","confidence":1,"confidence_rate":1},{"cnt":[[370,722],[1876,722],[1876,758],[370,758]],"region":{"top_left_x":369,"top_left_y":721,"width":1507,"height":38},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"934528f607c945f09b92d2303741a483","type":"text","conversion_output":true,"text":"Collect one time sample of 10 cc in purple top tube (ETDA tube) prior to start of therapy (preferable) or when patient is","text_display":"\nCollect one time sample of 10 cc in purple top tube (ETDA tube) prior to start of therapy (preferable) or when patient is","confidence":0.9990234375,"confidence_rate":0.9999925417098908},{"cnt":[[372,758],[1137,758],[1137,797],[372,797]],"region":{"top_left_x":371,"top_left_y":758,"width":766,"height":40},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39858509d2594d398281f7fc7a1219b8","type":"text","conversion_output":true,"text":"not leukopenic ( \\(WBC >2000\\) ). See section 15.2 for details.","text_display":" not leukopenic ( \\(WBC >2000\\) ). See section 15.2 for details.","confidence":0.4431670802288181,"confidence_rate":0.9887607429513902},{"cnt":[[372,795],[1798,795],[1798,831],[372,831]],"region":{"top_left_x":371,"top_left_y":794,"width":1428,"height":38},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27e86ccf67184d04a3c8623007d5f6b3","type":"text","conversion_output":true,"text":"Collect 1 cc of PBSC into sodium heparin tube and then transfer to PAX gene tubes. See Section 15.5 for details.","text_display":"\nCollect 1 cc of PBSC into sodium heparin tube and then transfer to PAX gene tubes. See Section 15.5 for details.","confidence":0.97021484375,"confidence_rate":0.9997581273070567},{"cnt":[[372,829],[1794,829],[1794,868],[372,868]],"region":{"top_left_x":371,"top_left_y":829,"width":1423,"height":39},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f4a307754fe464597a38ddc3a651a65","type":"text","conversion_output":true,"text":"Tumor imaging \\(=\\) CT/MRI as needed for optimum visualization of all areas of bulk tumor (primary and tastases).","text_display":" Tumor imaging \\(=\\) CT/MRI as needed for optimum visualization of all areas of bulk tumor (primary and tastases).","confidence":0.650731086730957,"confidence_rate":0.9963344372076361},{"cnt":[[372,868],[1824,868],[1824,904],[372,904]],"region":{"top_left_x":371,"top_left_y":867,"width":1454,"height":38},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77ccd76be57a45e5bb675b1ea2b0f0ff","type":"text","conversion_output":true,"text":"CT/MRI required prior to surgical resection. Repeat imaging of surgical sites within 4-6 weeks post-operatively","text_display":" CT/MRI required prior to surgical resection. Repeat imaging of surgical sites within 4-6 weeks post-operatively","confidence":0.97314453125,"confidence_rate":0.999765349380052},{"cnt":[[372,902],[1858,902],[1858,939],[372,939]],"region":{"top_left_x":371,"top_left_y":902,"width":1488,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcd01798500b4c99987dce59b69487b2","type":"text","conversion_output":true,"text":"(can be the same as end of induction scans if this is within 4-6 weeks of surgical resection). If patient has radiographic","text_display":" (can be the same as end of induction scans if this is within 4-6 weeks of surgical resection). If patient has radiographic","confidence":1,"confidence_rate":1},{"cnt":[[372,939],[1158,939],[1158,973],[372,973]],"region":{"top_left_x":371,"top_left_y":938,"width":788,"height":36},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abdb5beb0f83472db140a1dd611176bd","type":"text","conversion_output":true,"text":"CR at end of induction submit these scans for Central Review.","text_display":" CR at end of induction submit these scans for Central Review.","confidence":1,"confidence_rate":1},{"cnt":[[372,975],[1592,975],[1592,1012],[372,1012]],"region":{"top_left_x":371,"top_left_y":975,"width":1221,"height":37},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0ff0bacdb2249ac9be52f855358dc51","type":"text","conversion_output":true,"text":"Obtain for tumors with intraspinal extension only. See Section 13.4 and Appendix III for details.","text_display":"\nObtain for tumors with intraspinal extension only. See Section 13.4 and Appendix III for details.","confidence":1,"confidence_rate":1},{"cnt":[[372,1010],[1577,1010],[1577,1046],[372,1046]],"region":{"top_left_x":371,"top_left_y":1009,"width":1206,"height":38},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfb98d75da12435fa9cfb57f5da88604","type":"text","conversion_output":true,"text":"Obtain if positive at diagnosis and results discordant with MIBG scan or tumor MIBG non-avid","text_display":" Obtain if positive at diagnosis and results discordant with MIBG scan or tumor MIBG non-avid","confidence":1,"confidence_rate":1},{"cnt":[[370,1044],[1792,1044],[1792,1083],[370,1083]],"region":{"top_left_x":369,"top_left_y":1044,"width":1423,"height":39},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"695e55f1f025481a884f8f6989ff189a","type":"text","conversion_output":true,"text":"MIBG scan can be performed within 2 weeks of starting chemotherapy if it is not possible to obtain scan prior to","text_display":" MIBG scan can be performed within 2 weeks of starting chemotherapy if it is not possible to obtain scan prior to","confidence":1,"confidence_rate":1},{"cnt":[[372,1079],[1794,1079],[1794,1119],[372,1119]],"region":{"top_left_x":371,"top_left_y":1078,"width":1423,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75486899c73745faafe324f500de24af","type":"text","conversion_output":true,"text":"starting chemotherapy. Repeat MIBG later in therapy only if positive at diagnosis. I \\({ }^{123}\\) MIBG scan preferred, see","text_display":" starting chemotherapy. Repeat MIBG later in therapy only if positive at diagnosis. I \\({ }^{123}\\) MIBG scan preferred, see","confidence":0.6289604329504073,"confidence_rate":0.9963839994009042},{"cnt":[[372,1117],[672,1117],[672,1154],[372,1154]],"region":{"top_left_x":371,"top_left_y":1117,"width":302,"height":37},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9a34d2394504be9960bce75f1e03ac3","type":"text","conversion_output":true,"text":"section 16.4 for details.","text_display":" section 16.4 for details.","confidence":1,"confidence_rate":1},{"cnt":[[370,1154],[1038,1154],[1038,1192],[370,1192]],"region":{"top_left_x":369,"top_left_y":1153,"width":669,"height":40},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32a915f7e8864f76a08b398c9907b631","type":"text","conversion_output":true,"text":"Repeat catecholamine levels if elevated at diagnosis.","text_display":"\nRepeat catecholamine levels if elevated at diagnosis.","confidence":1,"confidence_rate":1},{"cnt":[[372,1190],[926,1190],[926,1227],[372,1227]],"region":{"top_left_x":371,"top_left_y":1190,"width":555,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69fcb5267f464be5afa02cb36919c316","type":"text","conversion_output":true,"text":"Perform for all females of childbearing age.","text_display":"\nPerform for all females of childbearing age.","confidence":0.9609375,"confidence_rate":0.9991871487356367},{"cnt":[[245,1302],[1871,1302],[1871,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1301,"width":1628,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"023b5a657ade40c3924812cd4069c935","type":"text","conversion_output":true,"text":"PLEASE NOTE THAT END OF INDUCTION (Section 7.1.1) AND PRIOR TO CONSOLIDATION (Section 7.1.2) TESTS","text_display":"\n\nPLEASE NOTE THAT END OF INDUCTION (Section 7.1.1) AND PRIOR TO CONSOLIDATION 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Observation & Prior to Consolidation \\({ }^{1}\\) & During HSCT \\#1 chemo Regimen A and B & During Consolidation HSCT \\#1 Regimen A and B & Prior to HSCT \\# 2 Regimen B & During Consolidation HSCT \\#2 Regimen B & Post HSCT \\#1 (regimen A) or HSCT \\#2 (regimen B) & End of Consolidation Phase (after radiation) & At Relapse \\\\\n\\hline Physical Exam, Ht., Wt. & X & & X & & X & & X & \\\\\n\\hline CBC with diff./platelets & X & & \\(X ^{2}\\) & X & \\(X ^{2}\\) & & X & \\\\\n\\hline Electrolytes, BUN, Cr & X & \\(X ^{2}\\) & \\(X ^{3}\\) & X & \\(X ^{3}\\) & & X & \\\\\n\\hline Triglycerides & & & & & & & X & \\\\\n\\hline \\(Ca , Mg\\), Phos & X & \\(X ^{3}\\) & \\(X ^{4}\\) & X & \\(X ^{4}\\) & & X & \\\\\n\\hline AST, ALT, Bilirubin, Albumin & X & & \\(X ^{4}\\) & X & \\(X ^{4}\\) & & X & \\\\\n\\hline Urinalysis & X & & & X & & & X & \\\\\n\\hline ECG and MUGA or ECHO & \\(X ^{6}\\) & & & X & & & X & \\\\\n\\hline GFR or Creatinine Clearance \\({ }^{5}\\) & \\(X ^{6}\\) & & & X & & & X & \\\\\n\\hline Audiogram or BAERs & \\(X ^{6}\\) & & & & & & X & \\\\\n\\hline Bilateral BM Asp/Bx & \\(X ^{6}\\) & & & & & & X & \\(X ^{7}\\) \\\\\n\\hline BM PCR \\({ }^{8}\\) & \\(X ^{6}\\) & & & & & & X & \\\\\n\\hline BM ICC \\({ }^{8}\\) & \\(X ^{6}\\) & & & & & & & \\\\\n\\hline Peripheral Blood PCR \\({ }^{9}\\) & \\(X ^{6}\\) & & & & & & X & \\\\\n\\hline Peripheral blood for immune assessments & & & & & & & \\(X ^{10}\\) & \\\\\n\\hline Peripheral blood for immune recovery & & & & & & \\(X ^{11}\\) & \\(X ^{11}\\) & \\\\\n\\hline Tumor Imaging \\({ }^{12}\\) & \\(X ^{6}\\) & & & & & & X & X \\\\\n\\hline MRI Spine and Neurologic Assessment \\({ }^{13}\\) & \\(X ^{6}\\) & & & & & & X & \\\\\n\\hline Bone Scan \\({ }^{14}\\) & \\(X ^{6}\\) & & & & & & X & X \\\\\n\\hline MIBG \\({ }^{15}\\) & \\(X ^{6}\\) & & & & & & X & X \\\\\n\\hline Catecholamines VMA, HVA \\({ }^{16}\\) & \\(X ^{6}\\) & & & & & & X & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|l|l|l|}\n\\hline Observation & Prior to Consolidation \\({ }^{1}\\) & During HSCT \\#1 chemo Regimen A and B & During Consolidation HSCT \\#1 Regimen A and B & Prior to HSCT \\# 2 Regimen B & During Consolidation HSCT \\#2 Regimen B & Post HSCT \\#1 (regimen A) or HSCT \\#2 (regimen B) & End of Consolidation Phase (after radiation) & At Relapse \\\\\n\\hline Physical Exam, Ht., Wt. & X & & X & & X & & X & \\\\\n\\hline CBC with diff./platelets & X & & \\(X ^{2}\\) & X & \\(X ^{2}\\) & & X & \\\\\n\\hline Electrolytes, BUN, Cr & X & \\(X ^{2}\\) & \\(X ^{3}\\) & X & \\(X ^{3}\\) & & X & \\\\\n\\hline Triglycerides & & & & & & & X & \\\\\n\\hline \\(Ca , Mg\\), Phos & X & \\(X ^{3}\\) & \\(X ^{4}\\) & X & \\(X ^{4}\\) & & X & \\\\\n\\hline AST, ALT, Bilirubin, Albumin & X & & \\(X ^{4}\\) & X & \\(X ^{4}\\) & & X & \\\\\n\\hline Urinalysis & X & & & X & & & X & \\\\\n\\hline ECG and MUGA or ECHO & \\(X 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CBC daily until neutrophil engraftment, then weekly through radiation therapy.*","text_display":"\n2 Daily during consolidation chemotherapy administration and day of PBSC infusion. CBC daily until neutrophil engraftment, then weekly through radiation therapy.*","confidence":1,"confidence_rate":1},{"cnt":[[245,1818],[1162,1818],[1162,1854],[245,1854]],"region":{"top_left_x":244,"top_left_y":1817,"width":919,"height":38},"line":167,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7142e33e2a1430ba37581f987ee5d31","type":"text","conversion_output":true,"text":"3 Obtain every other day if stable. Obtain on day of PBSC infusion*.","text_display":"\n3 Obtain every other day if stable. 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Camera method","confidence":0.96337890625,"confidence_rate":0.9997892398393896},{"cnt":[[305,402],[2350,402],[2350,449],[305,449]],"region":{"top_left_x":305,"top_left_y":401,"width":2046,"height":49},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5427e8f5ae75465ea3a02b82e8fbca66","type":"text","conversion_output":true,"text":"is NOT allowed as measure of GFR prior to or during Consolidation therapy for patients whose GFR/creatinine clearance is \\(<100 ml / min / 1.73 m^{2}\\).","text_display":" is NOT allowed as measure of GFR prior to or during Consolidation therapy for patients whose GFR/creatinine clearance is \\(<100 ml / min / 1.73 m^{2}\\).","confidence":0.9814541339874268,"confidence_rate":0.999885860191975},{"cnt":[[245,443],[2421,443],[2421,483],[245,483]],"region":{"top_left_x":244,"top_left_y":442,"width":2178,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8df1004ac50645df9c1d9e74103e8ee8","type":"text","conversion_output":true,"text":"6 Must be performed within 1 month prior to start of consolidation therapy. These observations should have been performed at the end of induction and do not need to be","text_display":"\n6 Must be performed within 1 month prior to start of consolidation therapy. These observations should have been performed at the end of induction and do not need to be","confidence":1,"confidence_rate":1},{"cnt":[[305,481],[2464,481],[2464,522],[305,522]],"region":{"top_left_x":305,"top_left_y":481,"width":2160,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b06ae8301eef425d9934fb6daae1697e","type":"text","conversion_output":true,"text":"repeated unless consolidation begins \\(>4\\) weeks after the end of induction.MIBG obtained only if positive at diagnosis. Repeat catecholamine levels if elevated at diagnosis.","text_display":" repeated unless consolidation begins \\(>4\\) weeks after the end of induction.MIBG obtained only if positive at diagnosis. 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Label \"relapse\" specimen.","confidence":1,"confidence_rate":1},{"cnt":[[245,554],[2402,554],[2402,595],[245,595]],"region":{"top_left_x":244,"top_left_y":554,"width":2158,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d84306e323704755935ad89cfb6e587e","type":"text","conversion_output":true,"text":"8 Obtain 10 cc of bone marrow ( 5 cc from each side) in sodium heparin tube. See section 15.4 for details regarding bone marrow immunocytochemistry (ICC) and PCR","text_display":"\n8 Obtain 10 cc of bone marrow ( 5 cc from each side) in sodium heparin tube. See section 15.4 for details regarding bone marrow immunocytochemistry (ICC) and PCR","confidence":0.99365234375,"confidence_rate":0.9999642259866317},{"cnt":[[305,593],[432,593],[432,634],[305,634]],"region":{"top_left_x":305,"top_left_y":592,"width":127,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcc437d5958b41109e7801e410588fee","type":"text","conversion_output":true,"text":"analyses.","text_display":" analyses.","confidence":1,"confidence_rate":1},{"cnt":[[245,632],[1467,632],[1467,672],[245,672]],"region":{"top_left_x":244,"top_left_y":631,"width":1224,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c639f5393f674627a886bd16ef3ee960","type":"text","conversion_output":true,"text":"9 Obtain 2 ml peripheral blood in sodium heparin or EDTA tube. See section 15.6 for details.","text_display":"\n9 Obtain 2 ml peripheral blood in sodium heparin or EDTA tube. See section 15.6 for details.","confidence":1,"confidence_rate":1},{"cnt":[[245,670],[2447,670],[2447,715],[245,715]],"region":{"top_left_x":244,"top_left_y":670,"width":2204,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b71714a6b9614a75ade058ac62fb18b3","type":"text","conversion_output":true,"text":"10 Obtain 20 cc peripheral blood in sodium heparin tubes \\(2-3\\) months after final HSCT procedure, preferably prior to initiation of Accutane therapy or at the","text_display":"\n10 Obtain 20 cc peripheral blood in sodium heparin tubes \\(2-3\\) months after final HSCT procedure, preferably prior to initiation of Accutane therapy or at the","confidence":0.9108161092735827,"confidence_rate":0.9994441173100663},{"cnt":[[305,709],[1403,709],[1403,750],[305,750]],"region":{"top_left_x":305,"top_left_y":708,"width":1098,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06dfc9740d954752acc81051d59cb61a","type":"text","conversion_output":true,"text":"time of enrollment on ANBL0032 or ANBL0931. See section 15.8 for details.","text_display":" time of enrollment on ANBL0032 or ANBL0931. See section 15.8 for details.","confidence":1,"confidence_rate":1},{"cnt":[[247,750],[2361,750],[2361,793],[247,793]],"region":{"top_left_x":247,"top_left_y":749,"width":2115,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac78b0adf92b4c1a856bf62aaef81d08","type":"text","conversion_output":true,"text":"11 Send CBC with differential and measurement by flow cytometry of peripheral blood CD3, CD4 and CD8 at 1,3 and 6 months post the final HSCT","text_display":"\n11 Send CBC with differential and measurement by flow cytometry of peripheral blood CD3, CD4 and CD8 at 1,3 and 6 months post the final HSCT","confidence":0.8044602061854675,"confidence_rate":0.9985504930327939},{"cnt":[[305,791],[1717,791],[1717,831],[305,831]],"region":{"top_left_x":305,"top_left_y":790,"width":1412,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04347fbcf8454f7bb83efd47b97f9a6b","type":"text","conversion_output":true,"text":"procedure (HSCT on Regimen A or HSCT \\#2 on Regimen B). To be performed at local institutions.","text_display":" procedure (HSCT on Regimen A or HSCT \\#2 on Regimen B). 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See section 13.4 and Appendix III for details.","text_display":"\n13 Obtain for tumors with intraspinal extension only. 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Strata & Strata (cont.) \\\\\n\\hline 01 = non-randomly assigned to Trt 01:AT-CEM & 09 = stage 3; MYCN amp; PR \\\\\n\\hline 02 = stage 4s; \\(M Y C N\\) amp; CR/VGPR & 10 = stage 4; \\(M Y C N\\) not amp or indeterminant; PR* \\\\\n\\hline 03 = stage 2a/2b; \\(M Y C N\\) amp; CR/VGPR & 11 = stage 4; \\(M Y C N\\) amp; PR \\\\\n\\hline 04 = stage 3; MYCN amp; CR/VGPR & \\(12=\\) stage 4s; \\(M Y C N\\) amp; MR/NR \\\\\n\\hline 05 = stage 4; \\(M Y C N\\) not amp or indeterminant; & 13 = stage 2a/2b; MYCN amp; MR/NR \\\\\n\\hline \\multicolumn{2}{|l|}{CR/VGPR*} \\\\\n\\hline 06 = stage 4; \\(M Y C N\\) amp; CR/VGPR & \\(14=\\) stage 3; \\(M Y C N\\) amp; MR/NR \\\\\n\\hline \\(07=\\) stage 4s; \\(M Y C N\\) amp; PR & 15 = stage 4; \\(M Y C N\\) not amp or indeterminant; MR/NR* \\\\\n\\hline \\(08=\\) stage 2a/2b; \\(M Y C N\\) amp; PR & \\(16=\\) stage 4; \\(M Y C N\\) amp; MR/NR \\\\\n\\hline \\multicolumn{2}{|l|}{* - Excludes patients 12-18 months old} \\\\\n\\hline \\multicolumn{2}{|l|}{CR - Complete response} \\\\\n\\hline \\multicolumn{2}{|l|}{VGPR - Very Good Partial Response} \\\\\n\\hline \\multicolumn{2}{|l|}{PR - Partial Response} \\\\\n\\hline \\multicolumn{2}{|l|}{MR - Mixed Response} \\\\\n\\hline \\multicolumn{2}{|l|}{NR - No Response} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Strata & Strata (cont.) \\\\\n\\hline 01 = non-randomly assigned to Trt 01:AT-CEM & 09 = stage 3; MYCN amp; PR \\\\\n\\hline 02 = stage 4s; \\(M Y C N\\) amp; CR/VGPR & 10 = stage 4; \\(M Y C N\\) not amp or indeterminant; PR* \\\\\n\\hline 03 = stage 2a/2b; \\(M Y C N\\) amp; CR/VGPR & 11 = stage 4; \\(M Y C N\\) amp; PR \\\\\n\\hline 04 = stage 3; MYCN amp; CR/VGPR & \\(12=\\) stage 4s; \\(M Y C N\\) amp; MR/NR \\\\\n\\hline 05 = stage 4; \\(M Y C N\\) not amp or indeterminant; & 13 = stage 2a/2b; MYCN amp; MR/NR \\\\\n\\hline \\multicolumn{2}{|l|}{CR/VGPR*} \\\\\n\\hline 06 = stage 4; \\(M Y C N\\) amp; CR/VGPR & \\(14=\\) stage 3; \\(M Y C N\\) amp; MR/NR \\\\\n\\hline \\(07=\\) stage 4s; \\(M Y C N\\) amp; PR & 15 = stage 4; \\(M Y C N\\) not amp or indeterminant; MR/NR* \\\\\n\\hline \\(08=\\) stage 2a/2b; \\(M Y C N\\) amp; PR & \\(16=\\) stage 4; \\(M Y C N\\) amp; MR/NR \\\\\n\\hline \\multicolumn{2}{|l|}{* - Excludes patients 12-18 months old} \\\\\n\\hline \\multicolumn{2}{|l|}{CR - Complete response} \\\\\n\\hline \\multicolumn{2}{|l|}{VGPR - Very Good Partial Response} \\\\\n\\hline \\multicolumn{2}{|l|}{PR - Partial Response} \\\\\n\\hline \\multicolumn{2}{|l|}{MR - Mixed Response} \\\\\n\\hline \\multicolumn{2}{|l|}{NR - No Response} 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(cont.)","text_display":"Strata (cont.)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.999974295041004},{"cnt":[[358,342],[1103,342],[1103,383],[358,383]],"region":{"top_left_x":358,"top_left_y":341,"width":746,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f361bda8840475489da18b4360e32f7","type":"simple_cell","conversion_output":false,"parent_id":"f61f36b34de84e24a356f01ffbe8ff7e","text":"01 = non-randomly assigned to Trt 01:AT-CEM","text_display":"01 = non-randomly assigned to Trt 01:AT-CEM","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9897623062133789,"confidence_rate":0.9997810780219181},{"cnt":[[1173,428],[1629,428],[1629,472],[1173,472]],"region":{"top_left_x":1172,"top_left_y":428,"width":458,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54a840f813684e988ac35c010bc13eb9","type":"simple_cell","conversion_output":false,"parent_id":"f61f36b34de84e24a356f01ffbe8ff7e","text":"09 = stage 3; MYCN amp; PR","text_display":"09 = stage 3; MYCN amp; PR","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9005955588072538,"confidence_rate":0.9965161161056506},{"cnt":[[358,474],[950,474],[950,515],[358,515]],"region":{"top_left_x":358,"top_left_y":473,"width":592,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b91ec58fdf224921b835b5a971f6b0fe","type":"simple_cell","conversion_output":false,"parent_id":"f61f36b34de84e24a356f01ffbe8ff7e","text":"02 = stage 4s; \\(M Y C N\\) amp; CR/VGPR","text_display":"02 = stage 4s; \\(M Y C N\\) amp; 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Of the remaining 98 patients/year, 13 are estimated to be stratum 01","text_display":" to randomization/transplantation. Of the remaining 98 patients/year, 13 are estimated to be stratum 01","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[245,1616],[1878,1616],[1878,1659],[245,1659]],"region":{"top_left_x":244,"top_left_y":1615,"width":1634,"height":44},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a70277428c5b4f7b88fb18de2dd2c503","type":"text","conversion_output":true,"text":"patients who are non-randomly assigned to receive a single transplant (AT). Furthermore, the delayed","text_display":" patients who are non-randomly assigned to receive a single transplant (AT). Furthermore, the delayed","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1880,1659],[1880,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1636,"height":46},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62a1bab581db4db4842ab983d89f7a0f","type":"text","conversion_output":true,"text":"timing of randomization and the criteria to discontinue protocol therapy for those with progressive disease","text_display":" timing of randomization and the criteria to discontinue protocol therapy for those with progressive disease","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[1880,1702],[1880,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":1636,"height":46},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6e2364a764c43debcd45e8c154a2ec2","type":"text","conversion_output":true,"text":"should result in a very low rate for refusal of randomization (about \\(5 \\%\\) ). Therefore, the original estimate","text_display":" should result in a very low rate for refusal of randomization (about \\(5 \\%\\) ). Therefore, the original estimate","confidence":0.53515625,"confidence_rate":0.9945782595099069},{"cnt":[[245,1747],[1878,1747],[1878,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1746,"width":1634,"height":44},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04a5df0f94ca41c08e4f5b95839d801e","type":"text","conversion_output":true,"text":"was for 81 patients/year (69/year of which are Stage 4) to be randomized. However, as of the second","text_display":" was for 81 patients/year (69/year of which are Stage 4) to be randomized. However, as of the second","confidence":0.99853515625,"confidence_rate":0.9999862999285899},{"cnt":[[245,1790],[1878,1790],[1878,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1789,"width":1634,"height":46},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af9a34d51c0c418391784c22d64d27d8","type":"text","conversion_output":true,"text":"quarter of 2011, the annual accrual rate has reached 230 patients/year and the randomization rate is \\(50 \\%\\),","text_display":" quarter of 2011, the annual accrual rate has reached 230 patients/year and the randomization rate is \\(50 \\%\\),","confidence":0.8312690258026123,"confidence_rate":0.9984217442013291},{"cnt":[[245,1835],[1336,1835],[1336,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1834,"width":1093,"height":46},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3934e2b83cbf451fbb0803843f11f45e","type":"text","conversion_output":true,"text":"so the new estimate of the randomized patient rate is 115 patients/year.","text_display":" so the new estimate of the randomized patient rate is 115 patients/year.","confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[245,1927],[1880,1927],[1880,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1927,"width":1636,"height":44},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98c784e03ff044699776871a70a56cfb","type":"text","conversion_output":true,"text":"In the original plans, a total of 329 randomized patients were needed for sufficient power for an analysis","text_display":"\n\nIn the original plans, a total of 329 randomized patients were needed for sufficient power for an analysis","confidence":1,"confidence_rate":1},{"cnt":[[245,1970],[1880,1970],[1880,2015],[245,2015]],"region":{"top_left_x":244,"top_left_y":1970,"width":1636,"height":46},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ed6ad44518946849753e8d5d1008a36","type":"text","conversion_output":true,"text":"of the primary EFS treatment comparison. At an accrual rate of 81 patients per year, 329 would be","text_display":" of the primary EFS treatment comparison. At an accrual rate of 81 patients per year, 329 would be","confidence":1,"confidence_rate":1},{"cnt":[[245,2015],[1880,2015],[1880,2060],[245,2060]],"region":{"top_left_x":244,"top_left_y":2015,"width":1636,"height":46},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12d38d3e9fd5433a824f723f082a7ba5","type":"text","conversion_output":true,"text":"accrued in about 4.1 years, plus 3 of follow-up, for a total study duration of about 7 years. Including","text_display":" accrued in about 4.1 years, plus 3 of follow-up, for a total study duration of about 7 years. Including","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1880,2058],[1880,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2058,"width":1636,"height":46},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36231ebd97f144f09db5f4013c07daab","type":"text","conversion_output":true,"text":"stratum 01 patients and patients who go off protocol therapy or off study prior to randomization, the total","text_display":" stratum 01 patients and patients who go off protocol therapy or off study prior to randomization, the total","confidence":1,"confidence_rate":1},{"cnt":[[245,2101],[1880,2101],[1880,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2101,"width":1636,"height":46},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"319ef98511ec47a5ada376d49420e3e3","type":"text","conversion_output":true,"text":"study accrual was originally planned as 574 patients ( 140 /year for 4.1 years). Based on the observation of","text_display":" study accrual was originally planned as 574 patients ( 140 /year for 4.1 years). Based on the observation of","confidence":0.4853678182253134,"confidence_rate":0.9940925321519076},{"cnt":[[245,2144],[1880,2144],[1880,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1636,"height":46},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fad1c546d5764c37aa74289fec883de5","type":"text","conversion_output":true,"text":"higher EFS rates than anticipated in A3973 and ANBL0032, the power calculations below have been","text_display":" higher EFS rates than anticipated in A3973 and ANBL0032, the power calculations below have been","confidence":1,"confidence_rate":1},{"cnt":[[245,2189],[1431,2189],[1431,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2189,"width":1187,"height":48},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a63805b612404b8eb37de6b2dea3bd50","type":"text","conversion_output":true,"text":"revised, and a new total enrollment of up to 664 patients will be required.","text_display":" revised, and a new total enrollment of up to 664 patients will be required.","confidence":0.54638671875,"confidence_rate":0.9927441830609357},{"cnt":[[245,2277],[1880,2277],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2277,"width":1636,"height":46},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"579529f930fe478e864e626ce77e6bd1","type":"text","conversion_output":true,"text":"To increase the homogeneity of the patient cohort, patients will be strongly encouraged to enroll on","text_display":"\n\nTo increase the homogeneity of the patient cohort, patients will be strongly encouraged to enroll on","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1882,2320],[1882,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2320,"width":1639,"height":46},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fb2f048ad08405c9a8441d36efac532","type":"text","conversion_output":true,"text":"ANBL0032 or ANBL0931 after ANBL0532. The DSMC will be kept apprised of the proportion of","text_display":" ANBL0032 or ANBL0931 after ANBL0532. The DSMC will be kept apprised of the proportion of","confidence":1,"confidence_rate":1},{"cnt":[[245,2365],[1880,2365],[1880,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2365,"width":1636,"height":44},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"875cdb8170b242e28a9f8a117dc2bc43","type":"text","conversion_output":true,"text":"patients who enroll on ANBL0032 or ANBL0931, overall and by ANBL0032 treatment arm. (Prior to","text_display":" patients who enroll on ANBL0032 or ANBL0931, overall and by ANBL0032 treatment arm. 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hazard ratio of 0.7 ) with \\(80 \\%\\) power in a one-sided logrank test at a 0.05","text_display":" for AT1+AT2, which is a hazard ratio of 0.7 ) with \\(80 \\%\\) power in a one-sided logrank test at a 0.05","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1880,425],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3c6abebdb864bd1a50af05c2600e4a5","type":"text","conversion_output":true,"text":"significance level. The \\(46 \\% 3\\)-year EFS was chosen for the control group in this study based on the","text_display":" significance level. 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A 3 year follow-up provides","text_display":" supportive care occurring since the design of 3891 with \\(38 \\% 2\\)-year EFS. A 3 year follow-up provides","confidence":0.99462890625,"confidence_rate":0.9999523412248076},{"cnt":[[245,559],[1880,559],[1880,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":48},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e1b9d325d34456fa27bdc802fad6951","type":"text","conversion_output":true,"text":"time for sufficient events for \\(80 \\%\\) power and allows for some normalization of the EFS time post-","text_display":" time for sufficient events for \\(80 \\%\\) power and allows for some normalization of the EFS time post","confidence":1,"confidence_rate":1},{"cnt":[[245,604],[1880,604],[1880,649],[245,649]],"region":{"top_left_x":244,"top_left_y":603,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f90a1c8ea06d4afd833c86fc5ee59686","type":"text","conversion_output":true,"text":"transplant for 1 versus 2 transplants. The more patient-years of follow-up there are, the smaller the","text_display":"transplant for 1 versus 2 transplants. 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In order to","text_display":"\n\nThe new control arm 3 -year EFS will be \\(60 \\%\\), starting from the time of randomization. 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Due to the dilution effect of the crossovers, an intent-to-treat","confidence":1,"confidence_rate":1},{"cnt":[[245,385],[1880,385],[1880,428],[245,428]],"region":{"top_left_x":244,"top_left_y":384,"width":1636,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c157ad2f59f7400e974b480415182a7f","type":"text","conversion_output":true,"text":"comparison of treatment groups after 35\\% of patients have crossed from AT1+AT2 to AT would permit","text_display":" comparison of treatment groups after 35\\% of patients have crossed from AT1+AT2 to AT would permit","confidence":0.6826171875,"confidence_rate":0.9962636538185918},{"cnt":[[245,425],[1882,425],[1882,473],[245,473]],"region":{"top_left_x":244,"top_left_y":425,"width":1639,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98a5e2a63b3b4466ab303b0f776ce87a","type":"text","conversion_output":true,"text":"detection of a \\(16.3 \\%\\) difference ( \\(47 \\%\\) vs. \\(63 \\%\\) ) in the 3 -year EFS rate. Stated another way, if \\(35 \\%\\) of","text_display":" detection of a \\(16.3 \\%\\) difference ( \\(47 \\%\\) vs. \\(63 \\%\\) ) in the 3 -year EFS rate. Stated another way, if \\(35 \\%\\) of","confidence":0.9106236808455148,"confidence_rate":0.9992328718469835},{"cnt":[[245,473],[1880,473],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b31877f02494c338780485e338b2fb1","type":"text","conversion_output":true,"text":"AT1+AT2 patients cross to AT, an underlying true difference of \\(16.3 \\%\\) would need to exist in order for","text_display":" AT1+AT2 patients cross to AT, an underlying true difference of \\(16.3 \\%\\) would need to exist in order for","confidence":0.994631290435791,"confidence_rate":0.9999506143124046},{"cnt":[[245,516],[1880,516],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14c01a3417274b57919a4b4a3380f1fb","type":"text","conversion_output":true,"text":"the study to be able to detect a difference of \\(12 \\%\\) in an intent-to-treat analysis with \\(n =329\\). Per Table B , if","text_display":" the study to be able to detect a difference of \\(12 \\%\\) in an intent-to-treat analysis with \\(n =329\\). Per Table B , if","confidence":0.9921941757202148,"confidence_rate":0.9999401815663028},{"cnt":[[245,559],[1880,559],[1880,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba642dab41ea467e8d814b788434d237","type":"text","conversion_output":true,"text":"the underlying true difference is only \\(12 \\%\\), and there are \\(35 \\%\\) crossovers, then 688 patients would be","text_display":" the underlying true difference is only \\(12 \\%\\), and there are \\(35 \\%\\) crossovers, then 688 patients would be","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,606],[827,606],[827,649],[245,649]],"region":{"top_left_x":244,"top_left_y":605,"width":584,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"887dfa7e27c943079f9280cf759bcb88","type":"text","conversion_output":true,"text":"required to detect the 12\\% difference.","text_display":" required to detect the 12\\% difference.","confidence":0.629575252532959,"confidence_rate":0.989296994068869},{"cnt":[[243,690],[1467,690],[1467,741],[243,741]],"region":{"top_left_x":242,"top_left_y":689,"width":1226,"height":53},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c307eb44194e413d8ab4f71f2d5d6a80","type":"section_header","conversion_output":false,"children_ids":["3f0ee55a15c6418db592c80c89ef3a67"],"text":"","text_display":""},{"cnt":[[245,694],[1463,694],[1463,737],[245,737]],"region":{"top_left_x":244,"top_left_y":693,"width":1220,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f0ee55a15c6418db592c80c89ef3a67","type":"text","conversion_output":true,"parent_id":"c307eb44194e413d8ab4f71f2d5d6a80","text":"9.3.3 Power for detection of difference in proportion of induction responders","text_display":"\n\n\\subsection*{9.3.3 Power for detection of difference in proportion of induction responders}","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1876,735],[1876,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1632,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"535f0625a3b24505bbeef7d49481f67f","type":"text","conversion_output":true,"text":"All \\(n=664\\) patients on this study will be compared to \\(n=486\\) patients on A3973, for a total of 1,150","text_display":"\n\nAll \\(n=664\\) patients on this study will be compared to \\(n=486\\) patients on A3973, for a total of 1,150","confidence":0.5736880302429199,"confidence_rate":0.9948681250389044},{"cnt":[[245,782],[1878,782],[1878,827],[245,827]],"region":{"top_left_x":244,"top_left_y":782,"width":1634,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90df6775776543a4b3edf3010e6a55b5","type":"text","conversion_output":true,"text":"patients in the test of proportions. The power and detectable different were already very good per Table","text_display":" patients in the test of proportions. The power and detectable different were already very good per Table","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[245,825],[1880,825],[1880,870],[245,870]],"region":{"top_left_x":244,"top_left_y":825,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58e7a266d0fc42c1953eb6a8e6f6184d","type":"text","conversion_output":true,"text":"C, but with the increase in sample size from what was originally planned, the available power will be","text_display":" C, but with the increase in sample size from what was originally planned, the available power will be","confidence":0.99658203125,"confidence_rate":0.9999677003013677},{"cnt":[[245,868],[1880,868],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1636,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc92d23a1c3143f9a5e578c7ff34ec1c","type":"text","conversion_output":true,"text":"higher and/or the detectable difference will be smaller than what was originally planned (Table C). The","text_display":" higher and/or the detectable difference will be smaller than what was originally planned (Table C). The","confidence":0.9466476440429688,"confidence_rate":0.9994924591108288},{"cnt":[[245,911],[1880,911],[1880,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1636,"height":47},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"329be3e25b9447fdb7c123d6cc475f7f","type":"text","conversion_output":true,"text":"A3973 cohort will be nearly identical to the cohort on this study with the exception of the change in the","text_display":" A3973 cohort will be nearly identical to the cohort on this study with the exception of the change in the","confidence":0.9970703125,"confidence_rate":0.9999733277426675},{"cnt":[[245,954],[1878,954],[1878,999],[245,999]],"region":{"top_left_x":244,"top_left_y":953,"width":1634,"height":47},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc6beff15d494631916413c418d64aef","type":"text","conversion_output":true,"text":"induction therapy under study and the later timeframe of this study. Comparison will be made to assess","text_display":" induction therapy under study and the later timeframe of this study. Comparison will be made to assess","confidence":1,"confidence_rate":1},{"cnt":[[245,999],[728,999],[728,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":999,"width":485,"height":43},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cd2257381334dc9a85d021f24f88e68","type":"text","conversion_output":true,"text":"ability to achieve CR + VGPR.","text_display":" ability to achieve CR + VGPR.","confidence":0.68603515625,"confidence_rate":0.98897806206581},{"cnt":[[370,1087],[1545,1087],[1545,1128],[370,1128]],"region":{"top_left_x":369,"top_left_y":1087,"width":1176,"height":41},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e17ff61ddeb4f6798e2cccf9d352f39","type":"figure_label","conversion_output":false,"text":"Table C. - Detectable difference in CR + VGPR response rates with \\(n =1060\\)","text_display":"","confidence":0.9590606689453125,"confidence_rate":0.9994710140967962},{"cnt":[[352,1126],[1848,1126],[1848,1338],[352,1338]],"region":{"top_left_x":352,"top_left_y":1125,"width":1496,"height":214},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b8af90882d64b319ee8c190c33184ff","type":"table","conversion_output":true,"selected_labels":["4e17ff61ddeb4f6798e2cccf9d352f39"],"text":"\\begin{tabular}{|c|c|c|c|}\n\\hline \\begin{tabular}{c} \nPotential post-induction response rate on \\\\\nA3973 \\(( n =486)\\)\n\\end{tabular} & \\begin{tabular}{c} \nResponse rate on this study \\\\\n\\(( n =574)\\)\n\\end{tabular} & \\begin{tabular}{c} \nDetectable \\\\\ndifference\n\\end{tabular} & Power \\\\\n\\hline \\(50 \\%\\) & \\(58 \\%\\) & \\(8 \\%\\) & \\(79 \\%\\) \\\\\n\\hline \\(60 \\%\\) & \\(68 \\%\\) & \\(8 \\%\\) & \\(82 \\%\\) \\\\\n\\hline \\(70 \\%\\) & \\(78 \\%\\) & \\(8 \\%\\) & \\(87 \\%\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table C. - Detectable difference in CR + VGPR response rates with \\(n =1060\\)}\n\\begin{tabular}{|c|c|c|c|}\n\\hline \\begin{tabular}{c} \nPotential post-induction response rate on \\\\\nA3973 \\(( n =486)\\)\n\\end{tabular} & \\begin{tabular}{c} \nResponse rate on this study \\\\\n\\(( n =574)\\)\n\\end{tabular} & \\begin{tabular}{c} \nDetectable \\\\\ndifference\n\\end{tabular} & Power \\\\\n\\hline \\(50 \\%\\) & \\(58 \\%\\) & \\(8 \\%\\) & \\(79 \\%\\) \\\\\n\\hline \\(60 \\%\\) & \\(68 \\%\\) & \\(8 \\%\\) & \\(82 \\%\\) \\\\\n\\hline \\(70 \\%\\) & \\(78 \\%\\) & \\(8 \\%\\) & \\(87 \\%\\) \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.9795662818942219,"confidence_rate":0.9999260049787129},{"cnt":[[243,1379],[1373,1379],[1373,1429],[243,1429]],"region":{"top_left_x":242,"top_left_y":1379,"width":1131,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b1db38749924bb888bb5b8cf4294c96","type":"section_header","conversion_output":false,"children_ids":["5165cc5f31854ec99eb40794a1ff092b"],"text":"","text_display":""},{"cnt":[[249,1384],[1369,1384],[1369,1424],[249,1424]],"region":{"top_left_x":249,"top_left_y":1383,"width":1120,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5165cc5f31854ec99eb40794a1ff092b","type":"text","conversion_output":true,"parent_id":"6b1db38749924bb888bb5b8cf4294c96","text":"9.3.4 Power for detection of a difference in the risk of local recurrence","text_display":"\n\n\\subsection*{9.3.4 Power for detection of a difference in the risk of local recurrence}","confidence":1,"confidence_rate":1},{"cnt":[[247,1427],[1878,1427],[1878,1472],[247,1472]],"region":{"top_left_x":247,"top_left_y":1426,"width":1631,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"773eef43a99e4464a92b31079ca0146f","type":"text","conversion_output":true,"text":"There are two differences between ANBL0532 and A3973 in the cohort of patients who have pre-","text_display":"\n\nThere are two differences between ANBL0532 and A3973 in the cohort of patients who have pre","confidence":1,"confidence_rate":1},{"cnt":[[245,1470],[1878,1470],[1878,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1469,"width":1634,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe6697b286ea4fee9ae899ce891ec77b","type":"text","conversion_output":true,"text":"transplant <CR of the primary: 1) the number of transplants; and 2) the use of purging. For an unbiased","text_display":"transplant <CR of the primary: 1) the number of transplants; and 2) the use of purging. For an unbiased","confidence":1,"confidence_rate":1},{"cnt":[[245,1515],[1876,1515],[1876,1560],[245,1560]],"region":{"top_left_x":244,"top_left_y":1514,"width":1632,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03796aec07734b1db0dd89df62d97eb2","type":"text","conversion_output":true,"text":"comparison of analogous patients who achieve pre-transplant \\(< CR\\) of the primary, the Treatment 01","text_display":" comparison of analogous patients who achieve pre-transplant \\(< CR\\) of the primary, the Treatment 01","confidence":0.8972182273864746,"confidence_rate":0.9989773519340795},{"cnt":[[245,1560],[1876,1560],[1876,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1559,"width":1632,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"622fb37155614918a940a1982b30f108","type":"text","conversion_output":true,"text":"patients on ANBL0532 ( 36 Gy EBRT) will be compared to the unpurged patients ( \\(n =245\\) ) on A3973","text_display":" patients on ANBL0532 ( 36 Gy EBRT) will be compared to the unpurged patients ( \\(n =245\\) ) on A3973","confidence":0.6399993896484375,"confidence_rate":0.995913984732039},{"cnt":[[245,1603],[1880,1603],[1880,1648],[245,1648]],"region":{"top_left_x":244,"top_left_y":1602,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2da8bce49f8429ea7e86c0df99dd1f5","type":"text","conversion_output":true,"text":"(21.6 Gy EBRT) in terms of their risk for local recurrence. The following projections are based on","text_display":" (21.6 Gy EBRT) in terms of their risk for local recurrence. The following projections are based on","confidence":1,"confidence_rate":1},{"cnt":[[245,1646],[1880,1646],[1880,1691],[245,1691]],"region":{"top_left_x":244,"top_left_y":1645,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec38c2f1753342dc9fc7248439827070","type":"text","conversion_output":true,"text":"response rates from prior protocols. We assume \\(45 \\%(n=110)\\) of unpurged patients on A3973, and \\(45 \\%\\)","text_display":" response rates from prior protocols. We assume \\(45 \\%(n=110)\\) of unpurged patients on A3973, and \\(45 \\%\\)","confidence":0.87744140625,"confidence_rate":0.9987314354123336},{"cnt":[[245,1691],[1880,1691],[1880,1738],[245,1738]],"region":{"top_left_x":244,"top_left_y":1690,"width":1636,"height":49},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f55f2c5f4c534b188327c73cf4d8fae6","type":"text","conversion_output":true,"text":"( \\(n =149\\) ) of patients randomized to receive one transplant on this study will achieve less than CR at","text_display":" ( \\(n =149\\) ) of patients randomized to receive one transplant on this study will achieve less than CR at","confidence":0.905163322988507,"confidence_rate":0.9991107537909786},{"cnt":[[245,1736],[1878,1736],[1878,1781],[245,1781]],"region":{"top_left_x":244,"top_left_y":1735,"width":1634,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bbc8578153b4c3dbf68beeab2569b42","type":"text","conversion_output":true,"text":"primary site at end of induction therapy. If \\(75 \\%\\) of the A3973 patients and \\(90 \\%\\) of the ANBL0532","text_display":" primary site at end of induction therapy. If \\(75 \\%\\) of the A3973 patients and \\(90 \\%\\) of the ANBL0532","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,1779],[1880,1779],[1880,1824],[245,1824]],"region":{"top_left_x":244,"top_left_y":1778,"width":1636,"height":47},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be8a113ef273414ab458fe40c6becf51","type":"text","conversion_output":true,"text":"patients make it from randomization to consolidation and XRT, then the total number of patients utilized","text_display":" patients make it from randomization to consolidation and XRT, then the total number of patients utilized","confidence":1,"confidence_rate":1},{"cnt":[[245,1822],[1880,1822],[1880,1867],[245,1867]],"region":{"top_left_x":244,"top_left_y":1821,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2975dba3c4442adb2c0bac1c7013d62","type":"text","conversion_output":true,"text":"for the local recurrence risk comparison is \\(n =217\\) ( 83 from A3973 and 134 from ANBL0532). This will","text_display":" for the local recurrence risk comparison is \\(n =217\\) ( 83 from A3973 and 134 from ANBL0532). This will","confidence":0.9921875,"confidence_rate":0.9999323886869459},{"cnt":[[245,1865],[1880,1865],[1880,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1864,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41903d63917340abb6e334f7859eab95","type":"text","conversion_output":true,"text":"provide more than \\(80 \\%\\) power to detect a clinically significant decrease of \\(13 \\%\\) (from \\(19 \\%\\) to \\(6 \\%\\) ) in the","text_display":" provide more than \\(80 \\%\\) power to detect a clinically significant decrease of \\(13 \\%\\) (from \\(19 \\%\\) to \\(6 \\%\\) ) in the","confidence":0.9956073760986328,"confidence_rate":0.9999633148410898},{"cnt":[[245,1910],[1880,1910],[1880,1955],[245,1955]],"region":{"top_left_x":244,"top_left_y":1909,"width":1636,"height":47},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d0ca2f751b444fc87499e8e646371bb","type":"text","conversion_output":true,"text":"risk for local recurrence after 36 Gy, and more than \\(87 \\%\\) power to detect an \\(14 \\%\\) decrease (from \\(19 \\%\\) to","text_display":" risk for local recurrence after 36 Gy, and more than \\(87 \\%\\) power to detect an \\(14 \\%\\) decrease (from \\(19 \\%\\) to","confidence":0.978651660131691,"confidence_rate":0.9998171395033385},{"cnt":[[245,1955],[1300,1955],[1300,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1955,"width":1056,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b019ef38435f4fabb02e4f49adaa799c","type":"text","conversion_output":true,"text":"\\(5 \\%\\) ) in a one-sided Fisher's Exact test at a significance level of 0.05 .","text_display":" \\(5 \\%\\) ) in a one-sided Fisher's Exact test at a significance level of 0.05 .","confidence":0.693014069256184,"confidence_rate":0.9954266774081186},{"cnt":[[243,2041],[556,2041],[556,2090],[243,2090]],"region":{"top_left_x":242,"top_left_y":2041,"width":315,"height":50},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee65c45a50194a62b5b13706cd0fda46","type":"section_header","conversion_output":false,"children_ids":["648bfc68f4934c7389bca03df51a605b"],"text":"","text_display":""},{"cnt":[[249,2045],[552,2045],[552,2086],[249,2086]],"region":{"top_left_x":249,"top_left_y":2045,"width":304,"height":42},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"648bfc68f4934c7389bca03df51a605b","type":"text","conversion_output":true,"parent_id":"ee65c45a50194a62b5b13706cd0fda46","text":"9.3.5 Monitoring","text_display":"\n\n\\subsection*{9.3.5 Monitoring}","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1876,2093],[1876,2140],[245,2140]],"region":{"top_left_x":244,"top_left_y":2092,"width":1632,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d74749ccebd49bda707a11b50bcd187","type":"text","conversion_output":true,"text":"a) Monitoring for the proportion of \"crossovers\" from the two-transplant arm to the one-transplant","text_display":"\na) Monitoring for the proportion of \"crossovers\" from the two-transplant arm to the one-transplant","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[333,2144],[333,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2144,"width":90,"height":33},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"706a43f1296f4e79b0bc53692b9854d1","type":"text","conversion_output":true,"text":"arm:","text_display":" arm:","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1880,2183],[1880,2228],[245,2228]],"region":{"top_left_x":244,"top_left_y":2182,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c990687498be45e59bfb60b0197afdc2","type":"text","conversion_output":true,"text":"Of the eligible patients randomized to two transplants, patients who are unable to receive the second","text_display":"\nOf the eligible patients randomized to two transplants, patients who are unable to receive the second","confidence":1,"confidence_rate":1},{"cnt":[[245,2226],[1880,2226],[1880,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2225,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9b10948070f4d1fa94d91e98a514f49","type":"text","conversion_output":true,"text":"transplant except for reasons of disease progression (\"crossovers\") will be identified. The complement","text_display":" transplant except for reasons of disease progression (\"crossovers\") will be identified. The complement","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[1880,2269],[1880,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2268,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5486d59647f14337877629e783a92419","type":"text","conversion_output":true,"text":"cohort who are compliant with their randomized assignment shall be called the \"compliers\". A two-stage","text_display":" cohort who are compliant with their randomized assignment shall be called the \"compliers\". A two-stage","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,2314],[1880,2314],[1880,2359],[245,2359]],"region":{"top_left_x":244,"top_left_y":2313,"width":1636,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b88ce24daa5c44e1a12114f686838e96","type":"text","conversion_output":true,"text":"rule will be used to monitor the proportion of \"compliers\" within the cohort of eligible patients","text_display":" rule will be used to monitor the proportion of \"compliers\" within the cohort of eligible patients","confidence":1,"confidence_rate":1},{"cnt":[[245,2359],[844,2359],[844,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2358,"width":601,"height":44},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4930c9c23534e88a25d62f65017120f","type":"text","conversion_output":true,"text":"randomized to receive two transplants.","text_display":" randomized to receive two transplants.","confidence":1,"confidence_rate":1},{"cnt":[[1749,2587],[1876,2587],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2586,"width":128,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e958727345e94d97804e7722cefe601e","type":"page_info","conversion_output":false,"text":"Page 72","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-073","page":73,"lines":[{"cnt":[[245,122],[651,122],[651,236],[245,236]],"region":{"top_left_x":244,"top_left_y":122,"width":407,"height":115},"line":1,"column":0,"font_size":46,"is_printed":true,"is_handwritten":false,"id":"26e1b3ab982b479a8ff11003055da171","type":"page_info","conversion_output":false,"children_ids":["c926fc5e8515415b9a25a068b390d0c9","adacc3004bf34002888470ca66f07b51"],"text":"","text_display":""},{"cnt":[[258,125],[612,125],[612,187],[258,187]],"region":{"top_left_x":257,"top_left_y":124,"width":356,"height":63},"line":2,"column":0,"font_size":70,"is_printed":true,"is_handwritten":false,"id":"c926fc5e8515415b9a25a068b390d0c9","type":"text","conversion_output":false,"parent_id":"26e1b3ab982b479a8ff11003055da171","text":"CureSearch","text_display":"\nCureSearch","confidence":1,"confidence_rate":1},{"cnt":[[331,198],[651,198],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":197,"width":321,"height":33},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"adacc3004bf34002888470ca66f07b51","type":"text","conversion_output":false,"parent_id":"26e1b3ab982b479a8ff11003055da171","text":"Children's Oncology Group","text_display":"\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[653,133],[1648,133],[1648,161],[653,161]],"region":{"top_left_x":653,"top_left_y":133,"width":995,"height":29},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"51da31224adf4bea9eaacaa69309fb7f","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.966212449284285,"confidence_rate":0.9995704480069524},{"cnt":[[1708,129],[1876,129],[1876,161],[1708,161]],"region":{"top_left_x":1708,"top_left_y":128,"width":168,"height":34},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db92caef9abb47d287344de9e6d3323d","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,254],[1854,254],[1854,299],[370,299]],"region":{"top_left_x":369,"top_left_y":253,"width":1486,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"849a82fd9dd4440dbdef4f1df0d98b49","type":"text","conversion_output":true,"text":"- Stage 1: Accrue 33 patients randomized to the two-transplant arm. If 20 or fewer patients","text_display":"\n- Stage 1: Accrue 33 patients randomized to the two-transplant arm. If 20 or fewer patients","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[464,301],[1867,301],[1867,346],[464,346]],"region":{"top_left_x":464,"top_left_y":300,"width":1403,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9c1333717b04e639990a3fbe2ba4447","type":"text","conversion_output":true,"text":"are \"compliers\", then consider modifying the study design to maintain power. If more than","text_display":" are \"compliers\", then consider modifying the study design to maintain power. If more than","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[464,344],[1274,344],[1274,389],[464,389]],"region":{"top_left_x":464,"top_left_y":343,"width":811,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d6721f898174d7cb658d065803f485e","type":"text","conversion_output":true,"text":"20 patients are \"compliers\", then proceed to Stage 2.","text_display":" 20 patients are \"compliers\", then proceed to Stage 2.","confidence":1,"confidence_rate":1},{"cnt":[[372,391],[1848,391],[1848,436],[372,436]],"region":{"top_left_x":371,"top_left_y":391,"width":1477,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56a86955b29f4bd8aed37a10e8835086","type":"text","conversion_output":true,"text":"- Stage 2: Accrue an additional 46 patients to the two-transplant arm for a total of 79 . If 53","text_display":"\n- Stage 2: Accrue an additional 46 patients to the two-transplant arm for a total of 79 . If 53","confidence":0.99609375,"confidence_rate":0.999962725463083},{"cnt":[[464,434],[1811,434],[1811,479],[464,479]],"region":{"top_left_x":464,"top_left_y":433,"width":1348,"height":47},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be86f01e2e4c47eab7e691703a1075a8","type":"text","conversion_output":true,"text":"or fewer patients are \"compliers\", then consider modifying the study design to maintain","text_display":" or fewer patients are \"compliers\", then consider modifying the study design to maintain","confidence":1,"confidence_rate":1},{"cnt":[[464,486],[574,486],[574,522],[464,522]],"region":{"top_left_x":464,"top_left_y":485,"width":110,"height":38},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b585622445c345f3a05bb4cae7ef3a36","type":"text","conversion_output":true,"text":"power.","text_display":" power.","confidence":1,"confidence_rate":1},{"cnt":[[245,578],[1850,578],[1850,621],[245,621]],"region":{"top_left_x":244,"top_left_y":577,"width":1606,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92db9d911dea49d09b4d992ab1316d95","type":"text","conversion_output":true,"text":"This two-stage design has the following characteristics: The proportion of \"compliers\" is 0.61 under the","text_display":"\n\nThis two-stage design has the following characteristics: The proportion of \"compliers\" is 0.61 under the","confidence":1,"confidence_rate":1},{"cnt":[[245,621],[1798,621],[1798,664],[245,664]],"region":{"top_left_x":244,"top_left_y":620,"width":1555,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6670c696eaf443f9bba0eab7ed510ef","type":"text","conversion_output":true,"text":"null, and 0.75 under the alternative. This exact test will have \\(>90 \\%\\) power and a significance level of","text_display":" null, and 0.75 under the alternative. This exact test will have \\(>90 \\%\\) power and a significance level of","confidence":0.8725242614746094,"confidence_rate":0.99879395954724},{"cnt":[[245,666],[350,666],[350,703],[245,703]],"region":{"top_left_x":244,"top_left_y":666,"width":107,"height":37},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1df59e563674be1ac62bcc05106cd58","type":"text","conversion_output":true,"text":"<0.10.","text_display":" <0.10.","confidence":0.99658203125,"confidence_rate":0.99968879176719},{"cnt":[[245,752],[1878,752],[1878,797],[245,797]],"region":{"top_left_x":244,"top_left_y":751,"width":1634,"height":47},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a7249262ff549728f03661649619dc0","type":"text","conversion_output":true,"text":"b) Interim monitoring for futility or superiority of the experimental arm (AT1-TC \\& AT2-CEM)","text_display":"\nb) Interim monitoring for futility or superiority of the experimental arm (AT1-TC \\& AT2-CEM)","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[1878,799],[1878,842],[245,842]],"region":{"top_left_x":244,"top_left_y":799,"width":1634,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d1ab5b466124c8cb46cae36386e9959","type":"text","conversion_output":true,"text":"will start after \\(20 \\%\\) of the total expected information ( 177 events) has been observed, and will be","text_display":" will start after \\(20 \\%\\) of the total expected information ( 177 events) has been observed, and will be","confidence":0.9902465343475342,"confidence_rate":0.9999109008580961},{"cnt":[[245,842],[1880,842],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":842,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d2735fdeb5b47fdac01490af893868e","type":"text","conversion_output":true,"text":"performed on an annual basis. If issues of concern arise that require more frequent looks, then monitoring","text_display":" performed on an annual basis. If issues of concern arise that require more frequent looks, then monitoring","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[797,885],[797,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":554,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7c8d43e05d14aa5933a6a03a33f0765","type":"text","conversion_output":true,"text":"can be performed every six months.","text_display":" can be performed every six months.","confidence":1,"confidence_rate":1},{"cnt":[[245,971],[1880,971],[1880,1018],[245,1018]],"region":{"top_left_x":244,"top_left_y":971,"width":1636,"height":48},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0e4c96fdb7a4dfc992b233afeb32bca","type":"text","conversion_output":true,"text":"There will be cause to stop the trial early if the AT1 + AT2 arm appears to be insufficiently efficacious or","text_display":"\n\nThere will be cause to stop the trial early if the AT1 + AT2 arm appears to be insufficiently efficacious or","confidence":0.99853515625,"confidence_rate":0.9999870273612914},{"cnt":[[245,1018],[1878,1018],[1878,1061],[245,1061]],"region":{"top_left_x":244,"top_left_y":1018,"width":1634,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c75fff9471be446b83ada9793f59efac","type":"text","conversion_output":true,"text":"significantly more efficacious. The need for curtailment for non-significance of the AT1 + AT2 arm will","text_display":" significantly more efficacious. The need for curtailment for non-significance of the AT1 + AT2 arm will","confidence":1,"confidence_rate":1},{"cnt":[[245,1061],[1880,1061],[1880,1109],[245,1109]],"region":{"top_left_x":244,"top_left_y":1061,"width":1636,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e94df7b3080e41728ee4544c4b28519c","type":"text","conversion_output":true,"text":"be assessed using Fleming-Harrington-O'Brien boundaries for the hazard ratio (AT: AT1+AT2) at","text_display":" be assessed using Fleming-Harrington-O'Brien boundaries for the hazard ratio (AT: AT1+AT2) at","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,1109],[1880,1109],[1880,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1108,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"add0c5562cb742e89a03f9cfa9768837","type":"text","conversion_output":true,"text":"each interim analysis (Table D). The interim analyses of EFS will take place every year starting after","text_display":" each interim analysis (Table D). The interim analyses of EFS will take place every year starting after","confidence":1,"confidence_rate":1},{"cnt":[[245,1154],[1880,1154],[1880,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1153,"width":1636,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50c9f6d2e11045cba46dfc6e2ae04c32","type":"text","conversion_output":true,"text":"\\(20 \\%(40)\\) of the planned events have occurred. The lower bound is calculated based on repeated testing","text_display":" \\(20 \\%(40)\\) of the planned events have occurred. The lower bound is calculated based on repeated testing","confidence":0.9722299575805664,"confidence_rate":0.9997292393485354},{"cnt":[[245,1197],[1880,1197],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1196,"width":1636,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7066a16849b4fca8671f6366a23fb40","type":"text","conversion_output":true,"text":"of the alternative hypothesis that the relative risk is equal to 1.42 at a p-value of 0.005 . This relative risk","text_display":" of the alternative hypothesis that the relative risk is equal to 1.42 at a p-value of 0.005 . This relative risk","confidence":0.880859375,"confidence_rate":0.9989691716239599},{"cnt":[[245,1240],[1880,1240],[1880,1285],[245,1285]],"region":{"top_left_x":244,"top_left_y":1239,"width":1636,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e96241eb3dd5493cafdcba742bf8e3dc","type":"text","conversion_output":true,"text":"is calculated as control: experimental using the planning parameters for 3-year EFS. The upper bound","text_display":" is calculated as control: experimental using the planning parameters for 3-year EFS. The upper bound","confidence":0.9858636856079102,"confidence_rate":0.9998644169652824},{"cnt":[[245,1280],[1343,1280],[1343,1330],[245,1330]],"region":{"top_left_x":244,"top_left_y":1280,"width":1099,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"512ed5c9f55d44ab82d8fbf70121c9ee","type":"text","conversion_output":true,"text":"uses an alpha*t \\({ }^{2}\\) spending function for a cumulative alpha level of 0.05 .","text_display":" uses an alpha*t \\({ }^{2}\\) spending function for a cumulative alpha level of 0.05 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and,","text_display":" expected); and,","confidence":1,"confidence_rate":1},{"cnt":[[464,2316],[1880,2316],[1880,2361],[464,2361]],"region":{"top_left_x":464,"top_left_y":2316,"width":1416,"height":46},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33d5b1f42bfe4c20a85f1626589586b7","type":"text","conversion_output":true,"text":"vi) by ANBL0532 treatment arm, the proportion of patients who choose to enroll on","text_display":"\nvi) by ANBL0532 treatment arm, the proportion of patients who choose to enroll on","confidence":1,"confidence_rate":1},{"cnt":[[559,2359],[1377,2359],[1377,2404],[559,2404]],"region":{"top_left_x":558,"top_left_y":2358,"width":820,"height":47},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d8d961e92a44fb7be829118fc100ee4","type":"text","conversion_output":true,"text":"ANBL0032 or ANBL0931 (difference less than 5\\%).","text_display":" ANBL0032 or ANBL0931 (difference less than 5\\%).","confidence":1,"confidence_rate":1},{"cnt":[[243,2445],[879,2445],[879,2494],[243,2494]],"region":{"top_left_x":242,"top_left_y":2444,"width":637,"height":51},"line":105,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce9a53ffa9094f06a68ee9a2a4dd785e","type":"section_header","conversion_output":false,"children_ids":["1d37a05afaef4294ab4b4453b81d1ac9"],"text":"","text_display":""},{"cnt":[[245,2449],[872,2449],[872,2490],[245,2490]],"region":{"top_left_x":244,"top_left_y":2449,"width":629,"height":42},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d37a05afaef4294ab4b4453b81d1ac9","type":"text","conversion_output":true,"parent_id":"ce9a53ffa9094f06a68ee9a2a4dd785e","text":"9.3.6 Assessment of Study Objectives","text_display":"\n\n\\subsection*{9.3.6 Assessment of Study Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[1749,2587],[1876,2587],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2586,"width":128,"height":42},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88d87c93e1754fd88440aa59e0ea29df","type":"page_info","conversion_output":false,"text":"Page 73","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-074","page":74,"lines":[{"cnt":[[247,125],[614,125],[614,187],[247,187]],"region":{"top_left_x":247,"top_left_y":124,"width":368,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"4a92c04b67c2405ab4e572ca3a792a1d","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,129],[1648,129],[1648,165],[653,165]],"region":{"top_left_x":653,"top_left_y":128,"width":995,"height":38},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"33c7f21791c04955b1080d14ccdc10fc","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.2840219553014166,"confidence_rate":0.9843893328632539},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38096df19d5643e1a6b7759e342b3f24","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,198],[651,198],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":197,"width":321,"height":33},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"efb9356145bf4983b3a16d2243d479ea","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,254],[1880,254],[1880,299],[245,299]],"region":{"top_left_x":244,"top_left_y":253,"width":1636,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7644f67627c44b599253b82a12ffe45","type":"text","conversion_output":true,"text":"Primary Objective 1.1.1: Intent-to-treat log-rank test comparison of EFS curves, starting from the time","text_display":"\n\nPrimary Objective 1.1.1: Intent-to-treat log-rank test comparison of EFS curves, starting from the time","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"127fe24879c94798b5cd5055e2ca59fe","type":"text","conversion_output":true,"text":"of randomization, by treatment group (AT-CEM vs. AT1-TC \\& AT2-CEM). Kaplan-Meier curves will be","text_display":" of randomization, by treatment group (AT-CEM vs. AT1-TC \\& AT2-CEM). Kaplan-Meier curves will be","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1882,339],[1882,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1639,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e64359d1c0b4a4792d9af53401421ce","type":"text","conversion_output":true,"text":"generated starting from a) the time of randomization (this is the definitive analysis); b) the time of","text_display":" generated starting from a) the time of randomization (this is the definitive analysis); b) the time of","confidence":1,"confidence_rate":1},{"cnt":[[245,385],[1882,385],[1882,428],[245,428]],"region":{"top_left_x":244,"top_left_y":384,"width":1639,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fa1286cccd5438c90fdc989d9454023","type":"text","conversion_output":true,"text":"transplant; c) the time of completion of the last transplant (for descriptive purposes); and d) the time of","text_display":" transplant; c) the time of completion of the last transplant (for descriptive purposes); and d) the time of","confidence":0.9599802494049072,"confidence_rate":0.9996354006943758},{"cnt":[[245,425],[810,425],[810,475],[245,475]],"region":{"top_left_x":244,"top_left_y":425,"width":566,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a36bf2eef234514ab31ac0463a07810","type":"text","conversion_output":true,"text":"diagnosis (for descriptive purposes).","text_display":" diagnosis (for descriptive purposes).","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1882,520],[1882,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":1639,"height":47},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d276e61832849afb71f7c9605204c79","type":"text","conversion_output":true,"text":"Primary Objective 1.1.2: Chi-square test of proportions in all patients to compare the proportion of","text_display":"\n\nPrimary Objective 1.1.2: Chi-square test of proportions in all patients to compare the proportion of","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,563],[1878,563],[1878,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1634,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1c70e679cd84937aadd2347ba23ac6b","type":"text","conversion_output":true,"text":"Responders (CR+VGPRs) at the end of induction in this study to the analogous proportion in A3973.","text_display":" Responders (CR+VGPRs) at the end of induction in this study to the analogous proportion in A3973.","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1880,606],[1880,651],[245,651]],"region":{"top_left_x":244,"top_left_y":605,"width":1636,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad7c68436a964e9eb4a8c6f123db1801","type":"text","conversion_output":true,"text":"There is no reason to believe that the characteristics of the induction cohort on this study will differ from","text_display":" There is no reason to believe that the characteristics of the induction cohort on this study will differ from","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1596,649],[1596,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":1353,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d76d68d18c93449ca4bbcf4bac1c55a0","type":"text","conversion_output":true,"text":"that of the induction cohort on A3973, so this will be a fair and appropriate comparison.","text_display":" that of the induction cohort on A3973, so this will be a fair and appropriate comparison.","confidence":0.9990234375,"confidence_rate":0.9999896060152111},{"cnt":[[245,739],[1882,739],[1882,784],[245,784]],"region":{"top_left_x":244,"top_left_y":739,"width":1639,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bc25fc1d1e24e8fa14fe67692dc2437","type":"text","conversion_output":true,"text":"Primary Objective 1.1.3: Log-rank test to compare the risk for local recurrence within the subset of","text_display":"\n\nPrimary Objective 1.1.3: Log-rank test to compare the risk for local recurrence within the subset of","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[1880,782],[1880,829],[245,829]],"region":{"top_left_x":244,"top_left_y":782,"width":1636,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4aa1dfaa60284da095f9d01c5ef3d391","type":"text","conversion_output":true,"text":"patients who obtain a pre-transplant primary site \\(<\\) CR, i.e., comparing ANBL0532 patients randomized","text_display":" patients who obtain a pre-transplant primary site \\(<\\) CR, i.e., comparing ANBL0532 patients randomized","confidence":0.8640426731656559,"confidence_rate":0.9986478305508489},{"cnt":[[245,827],[1830,827],[1830,872],[245,872]],"region":{"top_left_x":244,"top_left_y":827,"width":1587,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcfcfa5ff52946ab8494f10af51c8a02","type":"text","conversion_output":true,"text":"to get one transplant versus the historical A3973 patients who were randomized to unpurged transplant.","text_display":" to get one transplant versus the historical A3973 patients who were randomized to unpurged transplant.","confidence":1,"confidence_rate":1},{"cnt":[[245,915],[1876,915],[1876,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1632,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"943bed0f0f90452da9fae60a9fa97a03","type":"text","conversion_output":true,"text":"Secondary Objective 1.2.1: The endpoints for this correlative aim are a) the duration of grade \\(>=3\\)","text_display":"\n\nSecondary Objective 1.2.1: The endpoints for this correlative aim are a) the duration of grade \\(>=3\\)","confidence":0.978515625,"confidence_rate":0.9997870959618445},{"cnt":[[245,958],[1878,958],[1878,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":958,"width":1634,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d4b76ed305d46ab8760084072134542","type":"text","conversion_output":true,"text":"neutropenia during cycle one; b) the duration of grade \\(>=3\\) thrombocytopenia during cycle one; and, c)","text_display":" neutropenia during cycle one; b) the duration of grade \\(>=3\\) thrombocytopenia during cycle one; and, c)","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1880,1001],[1880,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":1001,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86a339fae8964a88bbce0130ec54ccbd","type":"text","conversion_output":true,"text":"the response rate after two cycles of induction therapy. Of the total 664 patients, we will assume that","text_display":" the response rate after two cycles of induction therapy. Of the total 664 patients, we will assume that","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1880,1044],[1880,1091],[245,1091]],"region":{"top_left_x":244,"top_left_y":1044,"width":1636,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"beee781635c743aab042e51da29a6939","type":"text","conversion_output":true,"text":"\\(78 \\%(n=518)\\) will have biologic samples submitted for this correlative study. For a) and b), a logistic","text_display":" \\(78 \\%(n=518)\\) will have biologic samples submitted for this correlative study. For a) and b), a logistic","confidence":0.5117218917675204,"confidence_rate":0.993639608880568},{"cnt":[[245,1089],[1880,1089],[1880,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1089,"width":1636,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcf21635af5945e8b7c8c8a71c81c6d6","type":"text","conversion_output":true,"text":"regression model will be used to test the ability of the number of days of neutropenia or","text_display":" regression model will be used to test the ability of the number of days of neutropenia or","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[1878,1134],[1878,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1134,"width":1634,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b06ad84036d64cbd9abc18a142a57c9c","type":"text","conversion_output":true,"text":"thrombocytopenia to predict the presence of a polymorphism. For c), a chi-square test of association will","text_display":" thrombocytopenia to predict the presence of a polymorphism. For c), a chi-square test of association will","confidence":0.60009765625,"confidence_rate":0.995368369448295},{"cnt":[[245,1177],[1571,1177],[1571,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1177,"width":1327,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40064b8749f9471886468e21c44575cb","type":"text","conversion_output":true,"text":"be used to compare the proportion of responders with versus without a polymorphism.","text_display":" be used to compare the proportion of responders with versus without a polymorphism.","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1876,1268],[1876,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1267,"width":1632,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53f825dda0af42b486c91591250eae58","type":"text","conversion_output":true,"text":"For a particular genetic polymorphism, if the prevalence of homozygocity is \\(30 \\%\\), the resulting sample","text_display":"\n\nFor a particular genetic polymorphism, if the prevalence of homozygocity is \\(30 \\%\\), the resulting sample","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1880,1311],[1880,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1310,"width":1636,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc103c98e98b48a0bd4dfdf18c7abd0f","type":"text","conversion_output":true,"text":"sizes of 155 homozygous patients and 363 non-homozygous patients will result in more than \\(80 \\%\\) power","text_display":" sizes of 155 homozygous patients and 363 non-homozygous patients will result in more than \\(80 \\%\\) power","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[245,1354],[1880,1354],[1880,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b75c144315b48208a9394327e3972f1","type":"text","conversion_output":true,"text":"to detect a difference in response rates of \\(45 \\%\\) versus \\(30 \\%\\), respectively, assuming a 2 -sided 0.05 alpha","text_display":" to detect a difference in response rates of \\(45 \\%\\) versus \\(30 \\%\\), respectively, assuming a 2 -sided 0.05 alpha","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1880,1396],[1880,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1396,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"411a3fc239c8468ea4c39376a0beb849","type":"text","conversion_output":true,"text":"level. If the prevalence of homozygocity for a particular genetic polymorphism is \\(50 \\%\\), the resulting","text_display":" level. If the prevalence of homozygocity for a particular genetic polymorphism is \\(50 \\%\\), the resulting","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[245,1439],[1880,1439],[1880,1487],[245,1487]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"edf1acf23e894b63a5a402e3f5dc3d08","type":"text","conversion_output":true,"text":"sample sizes of 259 homozygous patients and 259 non-homozygous patients will result in more than \\(80 \\%\\)","text_display":" sample sizes of 259 homozygous patients and 259 non-homozygous patients will result in more than \\(80 \\%\\)","confidence":0.9990236759185791,"confidence_rate":0.9999911200303706},{"cnt":[[245,1485],[1878,1485],[1878,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1484,"width":1634,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"507761a4b2f548cc8ef0cd22a9860986","type":"text","conversion_output":true,"text":"power to detect a difference in response rates of \\(44 \\%\\) versus \\(30 \\%\\), respectively, assuming a 2 -sided 0.05","text_display":" power to detect a difference in response rates of \\(44 \\%\\) versus \\(30 \\%\\), respectively, assuming a 2 -sided 0.05","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1880,1530],[1880,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4779dd7f4dc421385f33c855a7e8e7b","type":"text","conversion_output":true,"text":"alpha level. If the prevalence of homozygocity for a particular genetic polymorphism is \\(10 \\%\\), the","text_display":" alpha level. If the prevalence of homozygocity for a particular genetic polymorphism is \\(10 \\%\\), the","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1878,1573],[1878,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1572,"width":1634,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"929eb5f3451441e287975884d74120a5","type":"text","conversion_output":true,"text":"resulting sample sizes of 52 homozygous patients and 466 non-homozygous patients will result in more","text_display":" resulting sample sizes of 52 homozygous patients and 466 non-homozygous patients will result in more","confidence":1,"confidence_rate":1},{"cnt":[[245,1616],[1880,1616],[1880,1663],[245,1663]],"region":{"top_left_x":244,"top_left_y":1615,"width":1636,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53726449b281458b9ed8feffc8194f9b","type":"text","conversion_output":true,"text":"than \\(80 \\%\\) power to detect a difference in response rates of \\(53 \\%\\) versus \\(30 \\%\\), respectively, assuming a 2 -","text_display":" than \\(80 \\%\\) power to detect a difference in response rates of \\(53 \\%\\) versus \\(30 \\%\\), respectively, assuming a 2 ","confidence":0.99951171875,"confidence_rate":0.9999959636403931},{"cnt":[[245,1663],[595,1663],[595,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1662,"width":352,"height":47},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"792631f7ae574baf8f9ae1b3d7664fa9","type":"text","conversion_output":true,"text":"sided 0.05 alpha level.","text_display":"sided 0.05 alpha level.","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1858,1749],[1858,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1615,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e466b4972584636b45d33c7823f0fd2","type":"text","conversion_output":true,"text":"Secondary Objective 1.2.2: A chi-square test of proportions will be used to test for association between","text_display":"\n\nSecondary Objective 1.2.2: A chi-square test of proportions will be used to test for association between","confidence":1,"confidence_rate":1},{"cnt":[[245,1794],[1858,1794],[1858,1837],[245,1837]],"region":{"top_left_x":244,"top_left_y":1793,"width":1615,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed8e952bb26e4983a33722a0fe99ecad","type":"text","conversion_output":true,"text":"the proportion of patients who achieve a surgical CR and the proportion of patients who do not relapse in","text_display":" the proportion of patients who achieve a surgical CR and the proportion of patients who do not relapse in","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,1835],[1835,1835],[1835,1882],[245,1882]],"region":{"top_left_x":244,"top_left_y":1834,"width":1591,"height":49},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccf124c4069f4940ba464e133c2eff4f","type":"text","conversion_output":true,"text":"the primary. A logrank test will compare the EFS curves for degree of surgical response (CR vs. <CR).","text_display":" the primary. A logrank test will compare the EFS curves for degree of surgical response (CR vs. <CR).","confidence":0.9912264347076416,"confidence_rate":0.999916868742156},{"cnt":[[245,1925],[1884,1925],[1884,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1641,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e057fd5a00249c3807936d9a96d126f","type":"text","conversion_output":true,"text":"Secondary Objective 1.2.3: The proportion of patients by type of surgical complication and type of","text_display":"\n\nSecondary Objective 1.2.3: The proportion of patients by type of surgical complication and type of","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1880,1968],[1880,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1967,"width":1636,"height":47},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a408d87da854d0a81312c4ca6d44411","type":"text","conversion_output":true,"text":"radiation therapy complication will be descriptively tabulated. The complications, described in more","text_display":" radiation therapy complication will be descriptively tabulated. The complications, described in more","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1772,2011],[1772,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2010,"width":1529,"height":47},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58ab6deb20804e66ae7d6b6f400fd5a4","type":"text","conversion_output":true,"text":"detail in section 13.5.2, are: bowel obstruction, chylous leak, renal injury/atrophy/loss and diarrhea.","text_display":" detail in section 13.5.2, are: bowel obstruction, chylous leak, renal injury/atrophy/loss and diarrhea.","confidence":1,"confidence_rate":1},{"cnt":[[245,2101],[1861,2101],[1861,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2101,"width":1617,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb1f92ee98e94fe5898b8151cf61e8aa","type":"text","conversion_output":true,"text":"Secondary Objective 1.2.4: For the patients with primary tumors with intraspinal extension: descriptive","text_display":"\n\nSecondary Objective 1.2.4: For the patients with primary tumors with intraspinal extension: descriptive","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,2144],[1790,2144],[1790,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1546,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3be91ee27ca4e08ba283a5d5b8cc7ac","type":"text","conversion_output":true,"text":"tabulation of the proportion of patients with resolution of neurologic symptoms by type of symptom.","text_display":" tabulation of the proportion of patients with resolution of neurologic symptoms by type of symptom.","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,2230],[1880,2230],[1880,2277],[245,2277]],"region":{"top_left_x":244,"top_left_y":2230,"width":1636,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"144a6ada50ea4144b044592e995eb038","type":"text","conversion_output":true,"text":"Secondary Objective 1.2.5: The cohort of patients for this analysis of the cis-RA PK data are patients","text_display":"\n\nSecondary Objective 1.2.5: The cohort of patients for this analysis of the cis-RA PK data are patients","confidence":0.99853515625,"confidence_rate":0.9999862999285899},{"cnt":[[245,2275],[1880,2275],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2275,"width":1636,"height":48},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6453014b8c404bc5ac399123e34ad4ac","type":"text","conversion_output":true,"text":"enrolled on either A3973, ANBL0032, ANBL0931, ANBL0532, and future high risk studies who receive cis-","text_display":" enrolled on either A3973, ANBL0032, ANBL0931, ANBL0532, and future high risk studies who receive cis","confidence":1,"confidence_rate":1},{"cnt":[[245,2320],[1880,2320],[1880,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2320,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9aa8ec0eb7f4f76993982ffd7249f81","type":"text","conversion_output":true,"text":"RA. The analyses will be conducted in the overall cohort as well as within the subset of patients who receive","text_display":"RA. The analyses will be conducted in the overall cohort as well as within the subset of patients who receive","confidence":0.99462890625,"confidence_rate":0.9999527592743642},{"cnt":[[245,2363],[1880,2363],[1880,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2363,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95a75c09e81b4d29af346fe6fbb8ff53","type":"text","conversion_output":true,"text":"only one transplant and cis-RA without the addition of antibody. Patients will be pooled across these studies","text_display":" only one transplant and cis-RA without the addition of antibody. Patients will be pooled across these studies","confidence":1,"confidence_rate":1},{"cnt":[[245,2408],[1880,2408],[1880,2454],[245,2454]],"region":{"top_left_x":244,"top_left_y":2408,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"05e6fe8db0dd4db5a42183dae1369104","type":"text","conversion_output":true,"text":"until at least 195 patients are available for analysis. We would not stop consenting patients to this aim or","text_display":" until at least 195 patients are available for analysis. We would not stop consenting patients to this aim or","confidence":1,"confidence_rate":1},{"cnt":[[245,2449],[1880,2449],[1880,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2449,"width":1636,"height":50},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43ed9c0d08034f5fa6a3dc803890bace","type":"text","conversion_output":true,"text":"collecting blood specimens in the middle of a study simply because the minimum accrual goal of \\(n =195\\) had","text_display":" collecting blood specimens in the middle of a study simply because the minimum accrual goal of \\(n =195\\) had","confidence":0.724609375,"confidence_rate":0.9972028535641353},{"cnt":[[1749,2587],[1876,2587],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2586,"width":128,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7381fa92697a4cd8bf28ac60ec473f26","type":"page_info","conversion_output":false,"text":"Page 74","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-075","page":75,"lines":[{"cnt":[[245,122],[651,122],[651,238],[245,238]],"region":{"top_left_x":244,"top_left_y":122,"width":407,"height":117},"line":1,"column":0,"font_size":46,"is_printed":true,"is_handwritten":false,"id":"f32ace8c5c7e4f16a3f4207e408f801a","type":"page_info","conversion_output":false,"children_ids":["6fdc754cb5ec4a65b6c62de72187a9de","c0432369b75c483891905e319f2e6cd8"],"text":"","text_display":""},{"cnt":[[249,125],[612,125],[612,187],[249,187]],"region":{"top_left_x":249,"top_left_y":124,"width":364,"height":63},"line":2,"column":0,"font_size":70,"is_printed":true,"is_handwritten":false,"id":"6fdc754cb5ec4a65b6c62de72187a9de","type":"text","conversion_output":false,"parent_id":"f32ace8c5c7e4f16a3f4207e408f801a","text":"CureSearch","text_display":"\nCureSearch","confidence":1,"confidence_rate":1},{"cnt":[[331,198],[651,198],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":197,"width":321,"height":33},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c0432369b75c483891905e319f2e6cd8","type":"text","conversion_output":false,"parent_id":"f32ace8c5c7e4f16a3f4207e408f801a","text":"Children's Oncology Group","text_display":"\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[653,131],[1648,131],[1648,161],[653,161]],"region":{"top_left_x":653,"top_left_y":131,"width":995,"height":31},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"46bb2a49c99d4afcb229456eb1688d9f","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.7818974747472747,"confidence_rate":0.9969293285164393},{"cnt":[[1708,129],[1876,129],[1876,161],[1708,161]],"region":{"top_left_x":1708,"top_left_y":128,"width":168,"height":34},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c846c57a9f3f4d20ab615aa087563054","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,254],[1878,254],[1878,296],[245,296]],"region":{"top_left_x":244,"top_left_y":253,"width":1634,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"859d1e5cdb1c483ea3b91188f39bad1a","type":"text","conversion_output":true,"text":"been reached; accrual of patients towards this aim would continue until that study's overall accrual was","text_display":"\nbeen reached; accrual of patients towards this aim would continue until that study's overall accrual was","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[245,296],[1566,296],[1566,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1323,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3bdd6da9524c42189c915f38164b0efe","type":"text","conversion_output":true,"text":"completed. A larger cohort would permit this aim to be addressed with greater accuracy.","text_display":" completed. A larger cohort would permit this aim to be addressed with greater accuracy.","confidence":1,"confidence_rate":1},{"cnt":[[247,378],[1878,378],[1878,428],[247,428]],"region":{"top_left_x":247,"top_left_y":378,"width":1631,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfb7a2b4c6084df586691ee45252d140","type":"text","conversion_output":true,"text":"1.2.5 a) For each patient, the peak serum concentration level will be determined. Pilot data \\({ }^{97,98}\\) indicate the","text_display":"\n1.2.5 a) For each patient, the peak serum concentration level will be determined. Pilot data \\({ }^{97,98}\\) indicate the","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1880,430],[1880,473],[245,473]],"region":{"top_left_x":244,"top_left_y":429,"width":1636,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b55bccbbabbe43faa0ed159dc8f52782","type":"text","conversion_output":true,"text":"mean peak serum concentration level will be approximately \\(7 \\mu M\\). Given a mean peak serum concentration","text_display":" mean peak serum concentration level will be approximately \\(7 \\mu M\\). Given a mean peak serum concentration","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[245,473],[1880,473],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d807ccf0640c44a487c30571cbf9eb50","type":"text","conversion_output":true,"text":"level of \\(7 \\mu M\\), a sample size of \\(n =195\\) will permit placement of a \\(90 \\%\\) confidence interval on the mean peak","text_display":" level of \\(7 \\mu M\\), a sample size of \\(n =195\\) will permit placement of a \\(90 \\%\\) confidence interval on the mean peak","confidence":0.9990236759185791,"confidence_rate":0.9999921856225626},{"cnt":[[245,518],[1880,518],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":517,"width":1636,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf7fddaaf7924d8bb168069aacf2243f","type":"text","conversion_output":true,"text":"serum concentration level with a precision of \\(+/-0.24 \\mu M\\). This confidence interval will provide a","text_display":" serum concentration level with a precision of \\(+/-0.24 \\mu M\\). This confidence interval will provide a","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1454,559],[1454,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1211,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d28a35cf7ea4052a280dc72cadba59c","type":"text","conversion_output":true,"text":"descriptive assessment of the inter-patient variability of the cis-RA plasma levels.","text_display":" descriptive assessment of the inter-patient variability of the cis-RA plasma levels.","confidence":1,"confidence_rate":1},{"cnt":[[245,653],[1876,653],[1876,696],[245,696]],"region":{"top_left_x":244,"top_left_y":653,"width":1632,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36c56e4585b04661ab59d07791625862","type":"text","conversion_output":true,"text":"To determine the relationship of peak serum concentration level with the existence of polymorphisms,","text_display":"\n\nTo determine the relationship of peak serum concentration level with the existence of polymorphisms,","confidence":1,"confidence_rate":1},{"cnt":[[245,696],[1878,696],[1878,741],[245,741]],"region":{"top_left_x":244,"top_left_y":696,"width":1634,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02d9d9677e414ba4b5a83bf6f03c301e","type":"text","conversion_output":true,"text":"Kendall's Tau statistic will be calculated. The allelic frequency of the known polymorphisms in","text_display":" Kendall's Tau statistic will be calculated. The allelic frequency of the known polymorphisms in","confidence":1,"confidence_rate":1},{"cnt":[[245,741],[1880,741],[1880,784],[245,784]],"region":{"top_left_x":244,"top_left_y":741,"width":1636,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7aa5ac77c26345d2b4a9101b384e1600","type":"text","conversion_output":true,"text":"UGT1A1 and UGT2B7 are such that the expected numbers of homozygotes for the variant forms are \\(25 \\%\\)","text_display":" UGT1A1 and UGT2B7 are such that the expected numbers of homozygotes for the variant forms are \\(25 \\%\\)","confidence":0.8056640625,"confidence_rate":0.9978627977762315},{"cnt":[[245,784],[1880,784],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":784,"width":1636,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef5830ebc0bc443cb7caf98545dda907","type":"text","conversion_output":true,"text":"in caucasians. Therefore, collection of 80 patient samples would allow us to detect a 2 -fold difference in","text_display":" in caucasians. Therefore, collection of 80 patient samples would allow us to detect a 2 -fold difference in","confidence":0.861328125,"confidence_rate":0.9987357172560155},{"cnt":[[245,829],[1880,829],[1880,872],[245,872]],"region":{"top_left_x":244,"top_left_y":829,"width":1636,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e9056f6b6524ef5a469a1013d625e50","type":"text","conversion_output":true,"text":"the peak serum concentration level of 13-cis retinoic acid with an expected power of greater than \\(90 \\%\\)","text_display":" the peak serum concentration level of 13-cis retinoic acid with an expected power of greater than \\(90 \\%\\)","confidence":0.9960966110229492,"confidence_rate":0.9999627528167163},{"cnt":[[245,872],[1878,872],[1878,917],[245,917]],"region":{"top_left_x":244,"top_left_y":872,"width":1634,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4110c8c721d4ec7b0bd181db9977fce","type":"text","conversion_output":true,"text":"and a \\(50 \\%\\) difference with a power of \\(50 \\%\\). The allelic frequency of the CYP2C8 variant, CYP2C8*3 in","text_display":" and a \\(50 \\%\\) difference with a power of \\(50 \\%\\). The allelic frequency of the CYP2C8 variant, CYP2C8*3 in","confidence":0.7033581733703613,"confidence_rate":0.9968061201910811},{"cnt":[[245,915],[1880,915],[1880,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3be23b1ac2104f0cb980491ff6a3a708","type":"text","conversion_output":true,"text":"Caucasians is 0.13 , giving a frequency of only \\(2 \\%\\) for homozygotes. However, the influence of this","text_display":" Caucasians is 0.13 , giving a frequency of only \\(2 \\%\\) for homozygotes. However, the influence of this","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[245,958],[1880,958],[1880,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":958,"width":1636,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb8e21528df94b549676b25431041d6b","type":"text","conversion_output":true,"text":"variant in those heterozygous for CYP2C8*3 has not been determined and evidence for variation between","text_display":" variant in those heterozygous for CYP2C8*3 has not been determined and evidence for variation between","confidence":1,"confidence_rate":1},{"cnt":[[245,1003],[1876,1003],[1876,1048],[245,1048]],"region":{"top_left_x":244,"top_left_y":1003,"width":1632,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2b63a43342d46b69bd4d13786a06b15","type":"text","conversion_output":true,"text":"heterozygotes and those possessing the homozygous wild-type genotype exists for other genes.","text_display":" heterozygotes and those possessing the homozygous wild-type genotype exists for other genes.","confidence":1,"confidence_rate":1},{"cnt":[[245,1048],[1880,1048],[1880,1091],[245,1091]],"region":{"top_left_x":244,"top_left_y":1048,"width":1636,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4be99194ed442b19e4f67e73a5cc9cb","type":"text","conversion_output":true,"text":"Combining heterozygotes and homozygous variants for this gene (CYP2C8) gives similar statistical","text_display":" Combining heterozygotes and homozygous variants for this gene (CYP2C8) gives similar statistical","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[1016,1091],[1016,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1091,"width":773,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3357e79496c48a6bfaa4a2cba3a5bc1","type":"text","conversion_output":true,"text":"power to that applied to the UGT polymorphisms.","text_display":" power to that applied to the UGT polymorphisms.","confidence":1,"confidence_rate":1},{"cnt":[[249,1179],[1876,1179],[1876,1222],[249,1222]],"region":{"top_left_x":249,"top_left_y":1179,"width":1627,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83a6934d3e0846eea6c0bec162a0fae4","type":"text","conversion_output":true,"text":"1.2.5 b) To determine if there is a relationship of the peak serum concentration level with event-free survival,","text_display":"\n1.2.5 b) To determine if there is a relationship of the peak serum concentration level with event-free survival,","confidence":1,"confidence_rate":1},{"cnt":[[245,1225],[1880,1225],[1880,1268],[245,1268]],"region":{"top_left_x":244,"top_left_y":1224,"width":1636,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce15c79f24134efa96be8c010221112d","type":"text","conversion_output":true,"text":"the term for this level will be tested in a Cox proportional hazards model. If the level is statistically","text_display":" the term for this level will be tested in a Cox proportional hazards model. If the level is statistically","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1880,1268],[1880,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1267,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bb94ff6470f4d8eb837572247f9880e","type":"text","conversion_output":true,"text":"significant, then a) the hazard ratio will provide a measure of increased risk for an event for a unit change in","text_display":" significant, then a) the hazard ratio will provide a measure of increased risk for an event for a unit change in","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1880,1311],[1880,1356],[245,1356]],"region":{"top_left_x":244,"top_left_y":1310,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"255affbe44fa46dab7f6d45dc99dc762","type":"text","conversion_output":true,"text":"the level; and, b) a cut-off in serum concentration level (low vs. high) will be identified that optimizes the","text_display":" the level; and, b) a cut-off in serum concentration level (low vs. high) will be identified that optimizes the","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1330,1354],[1330,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1086,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d16fda9bb2fa4257bb872609346e83a7","type":"text","conversion_output":true,"text":"difference in EFS between the low and high serum concentration groups.","text_display":" difference in EFS between the low and high serum concentration groups.","confidence":1,"confidence_rate":1},{"cnt":[[245,1444],[1880,1444],[1880,1487],[245,1487]],"region":{"top_left_x":244,"top_left_y":1443,"width":1636,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0eba7532b6d4e879a46d2cb0d193295","type":"text","conversion_output":true,"text":"To determine if there is a relationship of the peak serum concentration level with toxicity rates (CTC","text_display":"\n\nTo determine if there is a relationship of the peak serum concentration level with toxicity rates (CTC","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1712,1487],[1712,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1469,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61a963a71b3242d694522574eef0eb10","type":"text","conversion_output":true,"text":"grade 3 or 4 skin, hypercalcemia, or hepatic toxicity), Kendall's Tau statistic will be calculated.","text_display":" grade 3 or 4 skin, hypercalcemia, or hepatic toxicity), Kendall's Tau statistic will be calculated.","confidence":1,"confidence_rate":1},{"cnt":[[249,1573],[1884,1573],[1884,1618],[249,1618]],"region":{"top_left_x":249,"top_left_y":1572,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d93cd46b2f1c4f6c8a238b374b4ec299","type":"text","conversion_output":true,"text":"1.2.5 c) To determine if pharmacogenomic variations are predictive of EFS, a logrank test comparison of","text_display":"\n1.2.5 c) To determine if pharmacogenomic variations are predictive of EFS, a logrank test comparison of","confidence":1,"confidence_rate":1},{"cnt":[[245,1620],[1188,1620],[1188,1663],[245,1663]],"region":{"top_left_x":244,"top_left_y":1619,"width":945,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54d95abd70af4b5c9b99d613cfd9c820","type":"text","conversion_output":true,"text":"patients with vs without a given polymorphism will be made.","text_display":" patients with vs without a given polymorphism will be made.","confidence":1,"confidence_rate":1},{"cnt":[[245,1706],[1882,1706],[1882,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1705,"width":1639,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a2a10d72629443f99d011da0b256dc5","type":"text","conversion_output":true,"text":"A Fisher's exact test will test for association of the presence of a polymorphism with the occurrence of","text_display":"\n\nA Fisher's exact test will test for association of the presence of a polymorphism with the occurrence of","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1435,1749],[1435,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1192,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69b3c0342e6f4adb9cb360b7deb6e349","type":"text","conversion_output":true,"text":"systemic toxicity (CTC grade 3 or 4 skin, hypercalcemia, or hepatic toxicity).","text_display":" systemic toxicity (CTC grade 3 or 4 skin, hypercalcemia, or hepatic toxicity).","confidence":1,"confidence_rate":1},{"cnt":[[245,1839],[1560,1839],[1560,1882],[245,1882]],"region":{"top_left_x":244,"top_left_y":1839,"width":1316,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2aa78ad95768493c89f488485207216e","type":"text","conversion_output":true,"text":"These tests will be performed for UGT1A1, UGT2B7, CYP2C8 and CYP3A7 alleles.","text_display":"\n\nThese tests will be performed for UGT1A1, UGT2B7, CYP2C8 and CYP3A7 alleles.","confidence":1,"confidence_rate":1},{"cnt":[[245,1925],[1880,1925],[1880,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd8bc7a01881497f849a7b1b2e390db6","type":"text","conversion_output":true,"text":"Secondary Objective 1.2.6: The hypothesis for this aim is that topotecan systemic clearance can be","text_display":"\nSecondary Objective 1.2.6: The hypothesis for this aim is that topotecan systemic clearance can be","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,1968],[1878,1968],[1878,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1967,"width":1634,"height":47},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c9f9ae897904012850975a4050c7c84","type":"text","conversion_output":true,"text":"calculated with acceptable accuracy and precision using patient specific covariates in a dosing model. The","text_display":" calculated with acceptable accuracy and precision using patient specific covariates in a dosing model. The","confidence":1,"confidence_rate":1},{"cnt":[[245,2013],[1880,2013],[1880,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2013,"width":1636,"height":44},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2fb752e654b4e4d9ea0cb53fc4c7396","type":"text","conversion_output":true,"text":"topotecan total clearance value will be calculated from a single sample using Bayesian modeling","text_display":" topotecan total clearance value will be calculated from a single sample using Bayesian modeling","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1880,2058],[1880,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2058,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f49ee0f5791e43fd81ea5b7fcc4137cb","type":"text","conversion_output":true,"text":"techniques and population priors established from a similar patient population studied by Dr. Stewart's","text_display":" techniques and population priors established from a similar patient population studied by Dr. Stewart's","confidence":1,"confidence_rate":1},{"cnt":[[245,2101],[1880,2101],[1880,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2101,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7858fb3a1b534150ba8c87c6d80539ff","type":"text","conversion_output":true,"text":"laboratory. The two clearance values from course 1 and 2 will be used in the analysis separately and as","text_display":" laboratory. The two clearance values from course 1 and 2 will be used in the analysis separately and as","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,2144],[1880,2144],[1880,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"063fe818c80c4eaaa8e1f7b6c89accf5","type":"text","conversion_output":true,"text":"an average value. In addition to this topotecan clearance, a \"calculated\" topotecan clearance value will be","text_display":" an average value. In addition to this topotecan clearance, a \"calculated\" topotecan clearance value will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2189],[1880,2189],[1880,2232],[245,2232]],"region":{"top_left_x":244,"top_left_y":2189,"width":1636,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1af8c2d1e61547dab712f466c806f484","type":"text","conversion_output":true,"text":"determined from a topotecan dosing model, which consists of patient specific covariates determined from","text_display":" determined from a topotecan dosing model, which consists of patient specific covariates determined from","confidence":1,"confidence_rate":1},{"cnt":[[245,2234],[1882,2234],[1882,2277],[245,2277]],"region":{"top_left_x":244,"top_left_y":2234,"width":1639,"height":44},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"035ff438d25e4e7296167bff7deca3f9","type":"text","conversion_output":true,"text":"a) previous population pharmacokinetic analyses, b) planned population pharmacokinetic analyses of","text_display":" a) previous population pharmacokinetic analyses, b) planned population pharmacokinetic analyses of","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,2277],[1880,2277],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2277,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ef54c58a5bb479d9a7714fa0e16a34c","type":"text","conversion_output":true,"text":"already collected data, and c) population pharmacokinetic analyses of data that will be collected during","text_display":" already collected data, and c) population pharmacokinetic analyses of data that will be collected during","confidence":0.99853515625,"confidence_rate":0.9999865513043565},{"cnt":[[245,2320],[1880,2320],[1880,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2320,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e86ce25ce2814dc7b4f204f0d2cd835a","type":"text","conversion_output":true,"text":"this clinical trial. The relation between the topotecan clearance value determined by pharmacokinetic","text_display":" this clinical trial. The relation between the topotecan clearance value determined by pharmacokinetic","confidence":1,"confidence_rate":1},{"cnt":[[245,2365],[1876,2365],[1876,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2365,"width":1632,"height":44},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1561ddeec787495d84482413ff1665a9","type":"text","conversion_output":true,"text":"analysis (limited sampling; Bayesian modeling) and the topotecan clearance value determined by the","text_display":" analysis (limited sampling; Bayesian modeling) and the topotecan clearance value determined by the","confidence":1,"confidence_rate":1},{"cnt":[[245,2411],[1880,2411],[1880,2454],[245,2454]],"region":{"top_left_x":244,"top_left_y":2410,"width":1636,"height":44},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6db7bb60732487283a4786de897cee7","type":"text","conversion_output":true,"text":"topotecan dosing model (patient covariates) will be investigated using regression analysis and simulation","text_display":" topotecan dosing model (patient covariates) will be investigated using regression analysis and simulation","confidence":1,"confidence_rate":1},{"cnt":[[245,2454],[1880,2454],[1880,2499],[245,2499]],"region":{"top_left_x":244,"top_left_y":2453,"width":1636,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"adff1bba516b42c192463db572e1340d","type":"text","conversion_output":true,"text":"studies. The long-term goal is to identify relevant patient covariates that will enable the development of a","text_display":" studies. The long-term goal is to identify relevant patient covariates that will enable the development of a","confidence":1,"confidence_rate":1},{"cnt":[[1749,2587],[1876,2587],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2586,"width":128,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"035643751bfa433482ac67b75b05fb8f","type":"page_info","conversion_output":false,"text":"Page 75","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-076","page":76,"lines":[{"cnt":[[245,125],[617,125],[617,187],[245,187]],"region":{"top_left_x":244,"top_left_y":124,"width":373,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"0e642183e1da45e18c2d142829a45261","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[653,129],[1648,129],[1648,165],[653,165]],"region":{"top_left_x":653,"top_left_y":128,"width":995,"height":38},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b56632a956e4425ba33dbf28d177f992","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.27437859895850136,"confidence_rate":0.9839643820104957},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31f354ef5fbd4bdebe2533587cc4b338","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,198],[651,198],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":197,"width":321,"height":33},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cbc5e51590d34123bd567f45ad273662","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,254],[1880,254],[1880,299],[245,299]],"region":{"top_left_x":244,"top_left_y":253,"width":1636,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb8ba1a5a6014018b653cb60bc2fc6c1","type":"text","conversion_output":true,"text":"clinically useful dosing nomogram for topotecan in children with cancer. This approach will minimize","text_display":"\nclinically useful dosing nomogram for topotecan in children with cancer. This approach will minimize","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1764,296],[1764,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1520,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3724011c84c24626828fcbb849b4113b","type":"text","conversion_output":true,"text":"the interpatient variability in topotecan systemic exposure by individualizing the topotecan dosage.","text_display":" the interpatient variability in topotecan systemic exposure by individualizing the topotecan dosage.","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1878,382],[1878,428],[245,428]],"region":{"top_left_x":244,"top_left_y":382,"width":1634,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f67938bc9f0447c82cd70183f204531","type":"text","conversion_output":true,"text":"Secondary Objective 1.2.7. We hypothesize that: i) \\(T\\) cells recognizing antigens expressed on","text_display":"\n\nSecondary Objective 1.2.7. We hypothesize that: i) \\(T\\) cells recognizing antigens expressed on","confidence":0.8012616634368896,"confidence_rate":0.9977867756577115},{"cnt":[[245,430],[1880,430],[1880,475],[245,475]],"region":{"top_left_x":244,"top_left_y":429,"width":1636,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c86dc61dd0d462aa6accb24d4b4dbc3","type":"text","conversion_output":true,"text":"neuroblastoma cells circulate at diagnosis, and ii) anti-neuroblastoma T cells can demonstrate effector","text_display":" neuroblastoma cells circulate at diagnosis, and ii) anti-neuroblastoma T cells can demonstrate effector","confidence":0.8759765625,"confidence_rate":0.9988391309659886},{"cnt":[[245,477],[1878,477],[1878,522],[245,522]],"region":{"top_left_x":244,"top_left_y":476,"width":1634,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"289b3f2e102947b197d0155046785609","type":"text","conversion_output":true,"text":"function against neuroblastoma cells, We will assess functional immunity against neuroblastoma in","text_display":" function against neuroblastoma cells, We will assess functional immunity against neuroblastoma in","confidence":1,"confidence_rate":1},{"cnt":[[245,524],[1880,524],[1880,569],[245,569]],"region":{"top_left_x":244,"top_left_y":524,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9475be2e68e44e998e82532ec70d2708","type":"text","conversion_output":true,"text":"patient samples, including T cells collected at diagnosis and in patients after myeloablative therapy. We","text_display":" patient samples, including T cells collected at diagnosis and in patients after myeloablative therapy. We","confidence":0.8174679279327393,"confidence_rate":0.9982640635796103},{"cnt":[[245,567],[1880,567],[1880,612],[245,612]],"region":{"top_left_x":244,"top_left_y":567,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c0836a753b44854ad05a64011bac05d","type":"text","conversion_output":true,"text":"will look for functional T cell responses using both a specific tumor antigen (survivin) as well as","text_display":" will look for functional T cell responses using both a specific tumor antigen (survivin) as well as","confidence":0.9912149906158447,"confidence_rate":0.9999197866256545},{"cnt":[[245,612],[1115,612],[1115,655],[245,655]],"region":{"top_left_x":244,"top_left_y":612,"width":872,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1b48c3a8cda44b98611239c88919fb4","type":"text","conversion_output":true,"text":"allogeneic tumor RNA as a source of antigenic stimulus.","text_display":" allogeneic tumor RNA as a source of antigenic stimulus.","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[640,700],[640,746],[245,746]],"region":{"top_left_x":244,"top_left_y":700,"width":397,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"372399d5207f4bbdbe06c29028d2c2a8","type":"text","conversion_output":true,"text":"Assays used will include:","text_display":"\n\nAssays used will include:","confidence":1,"confidence_rate":1},{"cnt":[[247,743],[1880,743],[1880,788],[247,788]],"region":{"top_left_x":247,"top_left_y":743,"width":1633,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b579eae23564dcbaa987fcb0dd52423","type":"text","conversion_output":true,"text":"1. Survivin-specific cytotoxic T lymphocytes detected using peptide/MHC tetramers in HLA-A2+","text_display":"\n1. Survivin-specific cytotoxic T lymphocytes detected using peptide/MHC tetramers in HLA-A2+","confidence":0.9907269477844238,"confidence_rate":0.9999039601314876},{"cnt":[[245,786],[1880,786],[1880,834],[245,834]],"region":{"top_left_x":244,"top_left_y":786,"width":1636,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90f9a9aaabfb4a18885a1fd9024c1150","type":"text","conversion_output":true,"text":"patients. This assay provides measures of the presence of T-cells that are capable of recognizing","text_display":" patients. This assay provides measures of the presence of T-cells that are capable of recognizing","confidence":1,"confidence_rate":1},{"cnt":[[245,834],[1880,834],[1880,879],[245,879]],"region":{"top_left_x":244,"top_left_y":833,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"caca7c70575f461781bfe44ffaa2f64f","type":"text","conversion_output":true,"text":"neuroblastoma. For objective 1.2.7.a, the median number of survivin-specific T-cells will be calculated","text_display":" neuroblastoma. For objective 1.2.7.a, the median number of survivin-specific T-cells will be calculated","confidence":1,"confidence_rate":1},{"cnt":[[245,879],[1880,879],[1880,924],[245,924]],"region":{"top_left_x":244,"top_left_y":878,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92924838faa84ab4b30a8798ce8f96b4","type":"text","conversion_output":true,"text":"at diagnosis and post-transplant. The proportion of patients who are positive for survivin-specific","text_display":" at diagnosis and post-transplant. The proportion of patients who are positive for survivin-specific","confidence":1,"confidence_rate":1},{"cnt":[[245,924],[1878,924],[1878,969],[245,969]],"region":{"top_left_x":244,"top_left_y":923,"width":1634,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb1e995ed7f446288d4ee5040f1a8397","type":"text","conversion_output":true,"text":"immunity will be calculated at diagnosis and post-transplant. For objective 1.2.7.d, of the patients who","text_display":" immunity will be calculated at diagnosis and post-transplant. For objective 1.2.7.d, of the patients who","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1880,967],[1880,1012],[245,1012]],"region":{"top_left_x":244,"top_left_y":966,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d561be988124303b9e5cb9976949a0d","type":"text","conversion_output":true,"text":"were positive for survivin-specific immunity at diagnosis, the proportion of patients who remain positive","text_display":" were positive for survivin-specific immunity at diagnosis, the proportion of patients who remain positive","confidence":1,"confidence_rate":1},{"cnt":[[245,1010],[767,1010],[767,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1009,"width":523,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a405252dbeb4f3cbaa2e72ab54a4f97","type":"text","conversion_output":true,"text":"post-transplant will be calculated.","text_display":" post-transplant will be calculated.","confidence":0.9990236759185791,"confidence_rate":0.9999755802732609},{"cnt":[[245,1100],[1878,1100],[1878,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1100,"width":1634,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bed5303d195e48f892309bcab88f98d5","type":"text","conversion_output":true,"text":"2. IFN-gamma production in ELISPOT assays to antigen presenting cells (APCs) loaded with","text_display":"\n2. IFN-gamma production in ELISPOT assays to antigen presenting cells (APCs) loaded with","confidence":1,"confidence_rate":1},{"cnt":[[245,1143],[1878,1143],[1878,1188],[245,1188]],"region":{"top_left_x":244,"top_left_y":1142,"width":1634,"height":47},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00c6efbb6e17424886b49a133501f8da","type":"text","conversion_output":true,"text":"tumor RNA, survivin RNA, or control RNA. This assay provides a measure of the number of T-cells","text_display":" tumor RNA, survivin RNA, or control RNA. This assay provides a measure of the number of T-cells","confidence":1,"confidence_rate":1},{"cnt":[[245,1188],[1880,1188],[1880,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1188,"width":1636,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06f5b84c98ea482da06eb1a6cd619729","type":"text","conversion_output":true,"text":"that are capable of recognizing neuroblastoma. A sample of peripheral blood mononuclear cells","text_display":" that are capable of recognizing neuroblastoma. A sample of peripheral blood mononuclear cells","confidence":1,"confidence_rate":1},{"cnt":[[245,1233],[672,1233],[672,1278],[245,1278]],"region":{"top_left_x":244,"top_left_y":1233,"width":429,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"137fab03dbfa4a169807b34d965f078d","type":"text","conversion_output":true,"text":"(PBMC) will be exposed to","text_display":" (PBMC) will be exposed to","confidence":1,"confidence_rate":1},{"cnt":[[245,1323],[1878,1323],[1878,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1323,"width":1634,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9d8d3ecdbbb46e68674bb0685a51a2d","type":"text","conversion_output":true,"text":"APCs loaded with mRNA for survivin, mRNA from neuroblastoma cells and irrelevant mRNA. This","text_display":"\n\nAPCs loaded with mRNA for survivin, mRNA from neuroblastoma cells and irrelevant mRNA. This","confidence":1,"confidence_rate":1},{"cnt":[[245,1371],[1878,1371],[1878,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1370,"width":1634,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5239b3997cd474cb42ab218e8a56692","type":"text","conversion_output":true,"text":"assay does not require that the patient be HLA-A2+. For objective 1.2.7.b, the median number of T-cells","text_display":" assay does not require that the patient be HLA-A2+. For objective 1.2.7.b, the median number of T-cells","confidence":1,"confidence_rate":1},{"cnt":[[245,1414],[1880,1414],[1880,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1413,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd41fe3fa4294d2c80d0a6c887acabca","type":"text","conversion_output":true,"text":"and the median number of IFN-gamma-producing T-cells will be calculated using T-cells collected at","text_display":" and the median number of IFN-gamma-producing T-cells will be calculated using T-cells collected at","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,1457],[1880,1457],[1880,1504],[245,1504]],"region":{"top_left_x":244,"top_left_y":1456,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e250b1e1ec7b4be593089f5411e22744","type":"text","conversion_output":true,"text":"diagnosis and after completion of myeloablative therapy for each stimulating APC type. For each","text_display":" diagnosis and after completion of myeloablative therapy for each stimulating APC type. For each","confidence":1,"confidence_rate":1},{"cnt":[[245,1504],[1878,1504],[1878,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1503,"width":1634,"height":47},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aeb1b74e7fb24fbb90b3ba46fa7d3a24","type":"text","conversion_output":true,"text":"stimulating APC type, the median number of T-cells after transplant will be descriptively compared to a)","text_display":" stimulating APC type, the median number of T-cells after transplant will be descriptively compared to a)","confidence":1,"confidence_rate":1},{"cnt":[[245,1547],[1880,1547],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1546,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37d2a4f2dfcb4aacbcdb8577a1eaa67c","type":"text","conversion_output":true,"text":"the median number of T-cells at diagnosis; and, b) the median number of IFN-gamma-producing T-cells","text_display":" the median number of T-cells at diagnosis; and, b) the median number of IFN-gamma-producing T-cells","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,1590],[443,1590],[443,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1589,"width":199,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"360f8eaac7a844fd8957428acd3391db","type":"text","conversion_output":true,"text":"at diagnosis.","text_display":" at diagnosis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1678],[1876,1678],[1876,1723],[245,1723]],"region":{"top_left_x":244,"top_left_y":1677,"width":1632,"height":47},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4845abc56a24450ca2807c2b30ec05c7","type":"text","conversion_output":true,"text":"3. Response of APC-stimulated cytotoxic T-lymphocytes (CTL) response to neuroblastoma cells.","text_display":"\n3. Response of APC-stimulated cytotoxic T-lymphocytes (CTL) response to neuroblastoma cells.","confidence":1,"confidence_rate":1},{"cnt":[[245,1723],[1880,1723],[1880,1766],[245,1766]],"region":{"top_left_x":244,"top_left_y":1723,"width":1636,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ace09161c831429e8ecbe3e02a23c670","type":"text","conversion_output":true,"text":"The ability to lyse neuroblastoma cells will be evaluated for T cells stimulated by exposure to APCs","text_display":" The ability to lyse neuroblastoma cells will be evaluated for T cells stimulated by exposure to APCs","confidence":0.9712185859680176,"confidence_rate":0.9997219079914859},{"cnt":[[245,1766],[1880,1766],[1880,1813],[245,1813]],"region":{"top_left_x":244,"top_left_y":1766,"width":1636,"height":48},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4f28ad4b91e4eb089facb790eae883f","type":"text","conversion_output":true,"text":"loaded with mRNA for survivin, mRNA from neuroblastoma cells and irrelevant mRNA. The ability","text_display":" loaded with mRNA for survivin, mRNA from neuroblastoma cells and irrelevant mRNA. The ability","confidence":1,"confidence_rate":1},{"cnt":[[245,1813],[1880,1813],[1880,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1813,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48769fe8be7849c4bf02bf09b3cc56f4","type":"text","conversion_output":true,"text":"of stimulated T-cells to lyse neuroblastoma cells will be calculated at diagnosis and after myeloablative","text_display":" of stimulated T-cells to lyse neuroblastoma cells will be calculated at diagnosis and after myeloablative","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[245,1858],[1878,1858],[1878,1906],[245,1906]],"region":{"top_left_x":244,"top_left_y":1858,"width":1634,"height":48},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48ebf58730634a05bcc5f4498ba7b96c","type":"text","conversion_output":true,"text":"therapy. This assay provides a measure of the ability of stimulated T-cells to kill neuroblastoma cells.","text_display":" therapy. This assay provides a measure of the ability of stimulated T-cells to kill neuroblastoma cells.","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1880,1904],[1880,1951],[245,1951]],"region":{"top_left_x":244,"top_left_y":1903,"width":1636,"height":48},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b130da4032094d49900dc3bab6d267b3","type":"text","conversion_output":true,"text":"For objective 1.2.7.c, the proportion of patients whose stimulated T-cells lyse neuroblastoma cells will be","text_display":" For objective 1.2.7.c, the proportion of patients whose stimulated T-cells lyse neuroblastoma cells will be","confidence":0.98876953125,"confidence_rate":0.9998991657393055},{"cnt":[[245,1949],[1626,1949],[1626,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1948,"width":1383,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23916125907844689a6b277e6877cea1","type":"text","conversion_output":true,"text":"descriptively compared between diagnosis and after completion of myeloablative therapy.","text_display":" descriptively compared between diagnosis and after completion of myeloablative therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,2037],[1489,2037],[1489,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2036,"width":1245,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d0f544d203248e2821b58047894b3a0","type":"text","conversion_output":true,"text":"It is not necessary to perform treatment arm comparisons to assess this objective.","text_display":"\n\nIt is not necessary to perform treatment arm comparisons to assess this objective.","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[245,2123],[1880,2123],[1880,2170],[245,2170]],"region":{"top_left_x":244,"top_left_y":2122,"width":1636,"height":48},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"826a3eb1afcb406a8ec86ba5e2e30d23","type":"text","conversion_output":true,"text":"Secondary Objective 1.2.8. We hypothesize that patients who received the tandem myeloablative","text_display":"\nSecondary Objective 1.2.8. We hypothesize that patients who received the tandem myeloablative","confidence":1,"confidence_rate":1},{"cnt":[[245,2169],[1880,2167],[1880,2213],[245,2215]],"region":{"top_left_x":244,"top_left_y":2167,"width":1636,"height":49},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f39811262fd846ceb8a338ffcc949303","type":"text","conversion_output":true,"text":"chemotherapy regimen will experience slower T cell recovery, specifically of CD4+ T cells when","text_display":" chemotherapy regimen will experience slower T cell recovery, specifically of CD4+ T cells when","confidence":0.7029484938462671,"confidence_rate":0.9966487550836105},{"cnt":[[245,2213],[1882,2213],[1882,2258],[245,2258]],"region":{"top_left_x":244,"top_left_y":2212,"width":1639,"height":47},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8505285b940470ea17b0dfd65ea5bd1","type":"text","conversion_output":true,"text":"compared to patients who received a single myeloablative chemotherapy regimen. Enumeration of","text_display":" compared to patients who received a single myeloablative chemotherapy regimen. Enumeration of","confidence":1,"confidence_rate":1},{"cnt":[[245,2256],[1884,2256],[1884,2301],[245,2301]],"region":{"top_left_x":244,"top_left_y":2255,"width":1641,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96ab36c87e7c4a6f8f280386630f394b","type":"text","conversion_output":true,"text":"peripheral blood CD3, CD4 and CD8 cells will be performed at 1,3 and 6 months after completion of","text_display":" peripheral blood CD3, CD4 and CD8 cells will be performed at 1,3 and 6 months after completion of","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,2299],[1880,2299],[1880,2346],[245,2346]],"region":{"top_left_x":244,"top_left_y":2298,"width":1636,"height":49},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0d1a110d6b74e49b56b2c1cafa3d0e4","type":"text","conversion_output":true,"text":"assigned myeloablative therapy. For each timepoint ( \\(1,3,6\\) months post-myeloablative therapy), we will","text_display":" assigned myeloablative therapy. For each timepoint ( \\(1,3,6\\) months post-myeloablative therapy), we will","confidence":0.9897661134600639,"confidence_rate":0.9999064897105875},{"cnt":[[245,2344],[1880,2344],[1880,2391],[245,2391]],"region":{"top_left_x":244,"top_left_y":2343,"width":1636,"height":49},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db0d96eaa93a42359284ed7903643202","type":"text","conversion_output":true,"text":"perform a descriptive comparison of the median number of T-cells (CD3, CD4, CD8) between treatment","text_display":" perform a descriptive comparison of the median number of T-cells (CD3, CD4, CD8) between treatment","confidence":0.9975595474243164,"confidence_rate":0.9999762776082356},{"cnt":[[245,2389],[1012,2389],[1012,2434],[245,2434]],"region":{"top_left_x":244,"top_left_y":2389,"width":768,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc68627ea8194551b9c858a49b158a0e","type":"text","conversion_output":true,"text":"arms (single vs. tandem myeloablative regimens).","text_display":" arms (single vs. tandem myeloablative regimens).","confidence":1,"confidence_rate":1},{"cnt":[[1749,2585],[1876,2585],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2584,"width":128,"height":44},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9f6fbcbf1844c178864680d807dfa45","type":"page_info","conversion_output":false,"text":"Page 76","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-077","page":77,"lines":[{"cnt":[[247,125],[614,125],[614,187],[247,187]],"region":{"top_left_x":247,"top_left_y":124,"width":368,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"cf9acc420d2e484aaa49c594e83389fa","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,131],[1648,131],[1648,163],[653,163]],"region":{"top_left_x":653,"top_left_y":131,"width":995,"height":33},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fa86c2af5bc448cd8e01923d33c0f2ca","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.7061986938819799,"confidence_rate":0.9956612068157733},{"cnt":[[1708,129],[1876,129],[1876,161],[1708,161]],"region":{"top_left_x":1708,"top_left_y":128,"width":168,"height":34},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ce5fe503351493186a7fe4cdcae5c2c","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,198],[651,198],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":197,"width":321,"height":33},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6d7ff9b26edd4764b718713e8de85db0","type":"text","conversion_output":true,"text":"Children's Oncology Group","text_display":"\n\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[245,254],[1878,254],[1878,299],[245,299]],"region":{"top_left_x":244,"top_left_y":253,"width":1634,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36c67b2220f04917b67cc33096ffd3f5","type":"text","conversion_output":true,"text":"Secondary Objective 1.2.9 - The proportion of patients with neuroblastoma detected in bone marrow and","text_display":"\nSecondary Objective 1.2.9 - The proportion of patients with neuroblastoma detected in bone marrow and","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd31baee3292449fb7aa8419565f51ed","type":"text","conversion_output":true,"text":"peripheral blood using RT-PCR technique will be calculated overall and by treatment arm. Data from","text_display":" peripheral blood using RT-PCR technique will be calculated overall and by treatment arm. Data from","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2061c8c735df443aaf0305c0ab141fe0","type":"text","conversion_output":true,"text":"CCG-3891 indicate that by immunocytology \\(\\sim 15 \\%\\) of patients prior to myeloablative therapy show","text_display":" CCG-3891 indicate that by immunocytology \\(\\sim 15 \\%\\) of patients prior to myeloablative therapy show","confidence":0.9980475902557373,"confidence_rate":0.9999806505022475},{"cnt":[[245,378],[1878,378],[1878,428],[245,428]],"region":{"top_left_x":244,"top_left_y":378,"width":1634,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97cc9aec446b45ae83983a9122cf4baa","type":"text","conversion_output":true,"text":"minimal residual disease in bone marrow, \\({ }^{119}\\) and \\(\\sim 5 \\%\\) of patients in peripheral blood at the time of bone","text_display":" minimal residual disease in bone marrow, \\({ }^{119}\\) and \\(\\sim 5 \\%\\) of patients in peripheral blood at the time of bone","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1880,425],[1880,473],[245,473]],"region":{"top_left_x":244,"top_left_y":425,"width":1636,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9179343b3a6e4a098beaa0880764821d","type":"text","conversion_output":true,"text":"marrow harvest. Presumably residual disease found after transplant will be less than this figure, although","text_display":" marrow harvest. Presumably residual disease found after transplant will be less than this figure, although","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,473],[1880,473],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8b66c62dff74512bad100496f5bed4f","type":"text","conversion_output":true,"text":"the sensitivity of RT-PCR may increase the proportion of neuroblastoma positive specimens. If \\(15 \\%\\) of","text_display":" the sensitivity of RT-PCR may increase the proportion of neuroblastoma positive specimens. If \\(15 \\%\\) of","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,516],[1880,516],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4514ef480694a2497eab743c86c71ed","type":"text","conversion_output":true,"text":"the \\(n =478\\) randomized patients are positive for neuroblastoma by bone marrow RT-PCR or","text_display":" the \\(n =478\\) randomized patients are positive for neuroblastoma by bone marrow RT-PCR or","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9afb4a02190439388c5052b654b6d1d","type":"text","conversion_output":true,"text":"immunocytochemistry and if the EFS from time of transplant of the positive group is two thirds that of","text_display":" immunocytochemistry and if the EFS from time of transplant of the positive group is two thirds that of","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[245,604],[1878,604],[1878,649],[245,649]],"region":{"top_left_x":244,"top_left_y":603,"width":1634,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec026690205449d3ad4829ed4fd0246a","type":"text","conversion_output":true,"text":"the negative group, this study will have good power ( \\(>80 \\%\\) ) to detect this difference. The same","text_display":" the negative group, this study will have good power ( \\(>80 \\%\\) ) to detect this difference. The same","confidence":0.98095703125,"confidence_rate":0.9998151457285753},{"cnt":[[245,649],[1878,649],[1878,694],[245,694]],"region":{"top_left_x":244,"top_left_y":648,"width":1634,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35a4dbf1a9084b10a814fb253949a2a5","type":"text","conversion_output":true,"text":"considerations apply to peripheral blood; unless the EFS difference is quite large between the groups this","text_display":" considerations apply to peripheral blood; unless the EFS difference is quite large between the groups this","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1880,692],[1880,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ffbcf6fe55f40819b2e15b17cf1d7d0","type":"text","conversion_output":true,"text":"study will have limited power to detect differences by peripheral blood positivity. The statistical tool used","text_display":" study will have limited power to detect differences by peripheral blood positivity. The statistical tool used","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[245,735],[1880,735],[1880,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dce22217a3e422eb6c5dd81096bff47","type":"text","conversion_output":true,"text":"will be the log rank test, stratified by any other variables of interest. Cox regression techniques will be","text_display":" will be the log rank test, stratified by any other variables of interest. Cox regression techniques will be","confidence":1,"confidence_rate":1},{"cnt":[[245,780],[1880,780],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":779,"width":1636,"height":49},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39398f6a53d2455b9e4dc4be2398b5c3","type":"text","conversion_output":true,"text":"used for multivariate analysis, in particular for determination of whether these variables add independent","text_display":" used for multivariate analysis, in particular for determination of whether these variables add independent","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[612,825],[612,870],[245,870]],"region":{"top_left_x":244,"top_left_y":825,"width":369,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7d3f31254d74511885e9b332dd096b7","type":"text","conversion_output":true,"text":"prognostic information.","text_display":" prognostic information.","confidence":1,"confidence_rate":1},{"cnt":[[243,911],[698,911],[698,958],[243,958]],"region":{"top_left_x":242,"top_left_y":910,"width":457,"height":49},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8901af4565524c4cbb3d19702622500e","type":"section_header","conversion_output":false,"children_ids":["d96f2be23a0e489e95522f5e56dec417"],"text":"","text_display":""},{"cnt":[[245,915],[694,915],[694,956],[245,956]],"region":{"top_left_x":244,"top_left_y":915,"width":450,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d96f2be23a0e489e95522f5e56dec417","type":"text","conversion_output":true,"parent_id":"8901af4565524c4cbb3d19702622500e","text":"Secondary Objective 1.2.10","text_display":"\n\n\\section*{Secondary Objective 1.2.10}","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1880,954],[1880,999],[245,999]],"region":{"top_left_x":244,"top_left_y":953,"width":1636,"height":47},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27405760184e4b2d8aa9221bfc89a660","type":"text","conversion_output":true,"text":"A descriptive analysis of outcome will be performed of patients \\(12-18\\) months with Stage 4, MYCN","text_display":"\n\nA descriptive analysis of outcome will be performed of patients \\(12-18\\) months with Stage 4, MYCN","confidence":0.8442374301103519,"confidence_rate":0.9983574523181977},{"cnt":[[245,999],[1880,999],[1880,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":999,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82f5b9ad8c714904ab5cffb934e2c90a","type":"text","conversion_output":true,"text":"nonamplified tumor with unfavorable histopathology or diploid DNA content or with indeterminant","text_display":" nonamplified tumor with unfavorable histopathology or diploid DNA content or with indeterminant","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1880,1042],[1880,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1636,"height":49},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8004ee33b614491689b9ad4a2a451f25","type":"text","conversion_output":true,"text":"histology or ploidy and patients who are greater than 547 days of age with Stage 3, MYCN nonamplified","text_display":" histology or ploidy and patients who are greater than 547 days of age with Stage 3, MYCN nonamplified","confidence":0.9661123752593994,"confidence_rate":0.9996837644988691},{"cnt":[[245,1087],[1878,1087],[1878,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1634,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c034715a94b43d8abca8fd6f6470fce","type":"text","conversion_output":true,"text":"tumor AND unfavorable histopathology or indeterminant histology. Kaplan-Meier curves of EFS and OS","text_display":" tumor AND unfavorable histopathology or indeterminant histology. Kaplan-Meier curves of EFS and OS","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1579,1130],[1579,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1336,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd6cb0aee076485c83af328e327f2351","type":"text","conversion_output":true,"text":"will be plotted, and the proportion of responders to induction therapy will be tabulated.","text_display":" will be plotted, and the proportion of responders to induction therapy will be tabulated.","confidence":1,"confidence_rate":1},{"cnt":[[243,1216],[1038,1216],[1038,1265],[243,1265]],"region":{"top_left_x":242,"top_left_y":1216,"width":796,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1869cf75caf4466183c5810a36aac951","type":"section_header","conversion_output":false,"children_ids":["344ec65b8fd2407c9e0562ef4ef61bcc"],"text":"","text_display":""},{"cnt":[[245,1220],[1033,1220],[1033,1263],[245,1263]],"region":{"top_left_x":244,"top_left_y":1220,"width":790,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"344ec65b8fd2407c9e0562ef4ef61bcc","type":"text","conversion_output":true,"parent_id":"1869cf75caf4466183c5810a36aac951","text":"9.4 Gender and Minority Accrual Estimates","text_display":"\n\n\\subsection*{9.4 Gender and Minority Accrual Estimates}","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1412,1306],[1412,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1168,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3df58b6875a3425582f47af908b6f5b9","type":"text","conversion_output":true,"text":"The gender and minority distribution of the study population is expected to be:","text_display":"\n\nThe gender and minority distribution of the study population is expected to be:","confidence":1,"confidence_rate":1},{"cnt":[[168,1364],[1957,1364],[1957,2078],[168,2078]],"region":{"top_left_x":167,"top_left_y":1364,"width":1791,"height":714},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5561025b72464bd0b6381a94b3996f44","type":"table","conversion_output":true,"children_ids":["2e008f0fab954cc7808e1bfa8c49c192","30fbaa95f15648aea103a56107f18e0f","e2b8743d484e48c492af3dbc83f38dea","060c8fef8d21493f8c1d2519760ef3f9","74e2c2bc301948bd917fcfe358312f36","a78285c01d524048b3ce136e9afcc1d2","8615c633b81649ada83803d041cfe4c3","09a819c84e564753b52d4b712046f9fd","3318601034df479fa3922955817c022b","4da379bf8d154fb3ad848d05da2f4a5e","f58877c1eb4e417ba73e554baba8bf13","2769e1cc138c4dc9b11ce1b03281fe57","12a1ccca62344259bcbc0b224a9d419c","663cc31c6e8c41a6b4caa3da9b5534b7","ae77f182318643888d3b4c16ff6ee23c","ca06263e68a344f6b9efab67b1e312ed","866737812e5d48ebbc59bf3560c1a7d6","9779fefce63f4805a6a48c0261257f98","ddb90c8dfae44b099c7cc7c0646efcfb","16bdfe8ebdd04d08b9d701707e90a8c4","432fd562d0524341b7aafa001cd4a14a","20905d0986d94a81b013a3e26127f196","e68f66c3720b4eb494208be804faf61c","00b6cb484dd749e583ce927d0c7e6af9","a95200102a1d4d65b031d7410005d3bd","60bc08900f0946abb3c8ab8aa5b679bb","08fb1587ab9a43beb5e9aa0f4d9ab3bf","15c2646f8bc34432b106fea2a2b1cef1","fbb7eaee66894d8fbd9e13ba6396b292","8937fe2d5f86483bb61a48ae21e320a4","36d54c013c8049b88bc7a2d1413a344b","f8d54045347f4a4db8860cd18e7824a6","679c51e455fb4ed78f3c669e79793e0b","4ef130ff49ee4d5cb0d8f1dacedc3be8","c5cc5bc22a194ce0816f95a120562e92","ba39e6e0d82e4b6e8ffa68a3cd2576ee","66f6586ee8c04ecabe7b8bd95a00b40a","8e778f025fa74b7490763ecc72669a9c","a1edb80fec0945ee8215bd488eebaadd","49f679aeaad14f7397705b6314dbd29c","90784646e78a469fa72bffc4c0d78fcb","d7b1dc19726c44abbcb90220ce9ef64a","c328ede8da7848db8df6f82b376af134","a47e823fd09f4ed49dc0c53ec4e59b8c","c79906f116b243ed810e2d9a7a891d3d","66171b20844446bc87d9f79b350bd785","8a7116207eb9416db3aa324750e5e580","2dc8917c0ea54dad805374ac200a63e7","128a78d04a3d4c08bef015eeac6af371","8b899f81d7134613a4c953a64c2f5402","10826b51d2e34a3d9bc7f34c99aecd05","7d889da3fb3b48f3ae3e36f057f37117","2057cc70c50041c69f8853188b6eac69","9400b8f192c04bf88f76e41c30175afd","e45579c919ff4ac88e801b1052b17b31","8845789f73d64650b39321f593ba0d32","d308cef802b24971aed767df71244002","66806028f67f4074b03600ee73f044b1","ee66f94164754fe3af7f3f4395e28dab","71448b6f4deb40b4b2c8cfe9db2b3a05"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline 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The descriptions and grading scales found in the revised CTCAE version 4.0 will be","text_display":" reporting. The descriptions and grading scales found in the revised CTCAE version 4.0 will be","confidence":0.99853515625,"confidence_rate":0.9999854860688677},{"cnt":[[245,473],[1880,473],[1880,522],[245,522]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":51},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3807b9930eea4e90b97dd0fb47ca5792","type":"text","conversion_output":true,"text":"utilized for reporting beginning July \\(1^{\\text {st }}\\), 2011. All appropriate treatment areas should have access","text_display":" utilized for reporting beginning July \\(1^{\\text {st }}\\), 2011. All appropriate treatment areas should have access","confidence":0.6937641054391861,"confidence_rate":0.9969577762863855},{"cnt":[[245,520],[1880,520],[1880,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":1636,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"560bdbf09a6d4d378a72d1d4202c2de8","type":"text","conversion_output":true,"text":"to a copy of the CTCAE version 4.0 , which can be downloaded from the CTEP web site","text_display":" to a copy of the CTCAE version 4.0 , which can be downloaded from the CTEP web site","confidence":0.9985356330871582,"confidence_rate":0.9999838963917971},{"cnt":[[245,563],[642,563],[642,612],[245,612]],"region":{"top_left_x":244,"top_left_y":562,"width":399,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0be9d91f72be48d4abeec29f622ab59c","type":"text","conversion_output":true,"text":"(http://ctep.cancer.gov).","text_display":" (http://ctep.cancer.gov).","confidence":0.99853515625,"confidence_rate":0.9999511372710721},{"cnt":[[243,645],[1190,645],[1190,703],[243,703]],"region":{"top_left_x":242,"top_left_y":644,"width":949,"height":59},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f7c0ae1e63f45c8b4425d02aa797025","type":"section_header","conversion_output":false,"children_ids":["df6a10203e22405283db0035abc3cbdf"],"text":"","text_display":""},{"cnt":[[247,649],[1184,649],[1184,698],[247,698]],"region":{"top_left_x":247,"top_left_y":648,"width":937,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df6a10203e22405283db0035abc3cbdf","type":"text","conversion_output":true,"parent_id":"6f7c0ae1e63f45c8b4425d02aa797025","text":"10.2 Response Criteria for Patients with Solid Tumors","text_display":"\n\n\\subsection*{10.2 Response Criteria for Patients with Solid Tumors}","confidence":1,"confidence_rate":1},{"cnt":[[245,696],[1880,696],[1880,741],[245,741]],"region":{"top_left_x":244,"top_left_y":696,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cdb44f059014d0d908b52a0d3ae385b","type":"text","conversion_output":true,"text":"This study will use the International Neuroblastoma Staging System (INSS) Response Evaluation","text_display":"\n\nThis study will use the International Neuroblastoma Staging System (INSS) Response Evaluation","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[1880,739],[1880,784],[245,784]],"region":{"top_left_x":244,"top_left_y":739,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a0c4e3629ee4240942ca752d205c0a4","type":"text","conversion_output":true,"text":"Criteria. This will allow direct comparison with legacy COG studies as well as Phase 3 trials performed","text_display":" Criteria. This will allow direct comparison with legacy COG studies as well as Phase 3 trials performed","confidence":1,"confidence_rate":1},{"cnt":[[245,782],[367,782],[367,827],[245,827]],"region":{"top_left_x":244,"top_left_y":782,"width":124,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee947a120ec44980844b5c4895ef3dbf","type":"text","conversion_output":true,"text":"abroad.","text_display":" abroad.","confidence":1,"confidence_rate":1},{"cnt":[[243,855],[896,855],[896,922],[243,922]],"region":{"top_left_x":242,"top_left_y":855,"width":654,"height":67},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fd51b4f3a37445b9ff9b4cee129eac6","type":"section_header","conversion_output":false,"children_ids":["096be87d86b542a6850b59da7ae5396f"],"text":"","text_display":""},{"cnt":[[245,862],[892,862],[892,917],[245,917]],"region":{"top_left_x":244,"top_left_y":861,"width":648,"height":57},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"096be87d86b542a6850b59da7ae5396f","type":"text","conversion_output":true,"parent_id":"2fd51b4f3a37445b9ff9b4cee129eac6","text":"10.3 International Staging System \\({ }^{ 1 2 3 }\\)","text_display":"\n\n\\subsection*{10.3 International Staging System \\({ }^{ 1 2 3 }\\)}","confidence":1,"confidence_rate":1},{"cnt":[[245,915],[1878,915],[1878,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1634,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a990d9bf855a4a2cb60d0a232081ce8b","type":"text","conversion_output":true,"text":"Stage 1: Localized tumor with complete gross excision, with or without microscopic residual disease;","text_display":"\n\nStage 1: Localized tumor with complete gross excision, with or without microscopic residual disease;","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[1880,958],[1880,1003],[245,1003]],"region":{"top_left_x":244,"top_left_y":958,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"932557045a694d429044f13a9d954061","type":"text","conversion_output":true,"text":"representative ipsilateral lymph nodes negative microscopically (nodes attached to and removed with the","text_display":" representative ipsilateral lymph nodes negative microscopically (nodes attached to and removed with the","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[748,1001],[748,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":504,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be16ee74d893470e8de74495fb743fdf","type":"text","conversion_output":true,"text":"primary tumor may be positive).","text_display":" primary tumor may be positive).","confidence":1,"confidence_rate":1},{"cnt":[[245,1089],[1880,1089],[1880,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1089,"width":1636,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31f3c8bb03764e68bbad43c2a142cb3e","type":"text","conversion_output":true,"text":"Stage 2A: Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph","text_display":"\n\nStage 2A: Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[898,1134],[898,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1134,"width":655,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab47145ace3b456980297d03f4c7b527","type":"text","conversion_output":true,"text":"nodes negative for tumor microscopically.","text_display":" nodes negative for tumor microscopically.","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1880,1220],[1880,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1220,"width":1636,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ffae7ecd998474d9001be1eac95d0b4","type":"text","conversion_output":true,"text":"Stage 2B: Localized tumor with or without complete gross excision; with ipsilateral nonadherent lymph","text_display":"\n\nStage 2B: Localized tumor with or without complete gross excision; with ipsilateral nonadherent lymph","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1729,1268],[1729,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1267,"width":1486,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbd7244ba5b04073a2f235b33e5df631","type":"text","conversion_output":true,"text":"nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically.","text_display":" nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically.","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1880,1354],[1880,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ae19fbbd44345149768fc24a86ba9c0","type":"text","conversion_output":true,"text":"Stage 3: Unresectable unilateral tumor infiltrating across the midline with or without regional lymph node","text_display":"\n\nStage 3: Unresectable unilateral tumor infiltrating across the midline with or without regional lymph node","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1880,1396],[1880,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1396,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"875b5ea1d20c40c2aeb7c4b7d57f6d66","type":"text","conversion_output":true,"text":"involvement; or, localized unilateral tumor with contralateral regional lymph node involvement; or,","text_display":" involvement; or, localized unilateral tumor with contralateral regional lymph node involvement; or,","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1880,1439],[1880,1487],[245,1487]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8196ce683f834ab6ab28681fc73d7993","type":"text","conversion_output":true,"text":"midline tumor with bilateral extension by infiltration (unresectable) or by lymph node involvement. The","text_display":" midline tumor with bilateral extension by infiltration (unresectable) or by lymph node involvement. The","confidence":1,"confidence_rate":1},{"cnt":[[245,1485],[1880,1485],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1484,"width":1636,"height":48},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7f6553ff0c347a7806986d4ad55374f","type":"text","conversion_output":true,"text":"midline is defined as the vertebral column. Tumors originating on one side and crossing the midline must","text_display":" midline is defined as the vertebral column. Tumors originating on one side and crossing the midline must","confidence":1,"confidence_rate":1},{"cnt":[[245,1530],[1231,1530],[1231,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":988,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8795b8648e0426cb66a5378c43282c8","type":"text","conversion_output":true,"text":"infiltrate to or beyond the opposite side of the vertebral column.","text_display":" infiltrate to or beyond the opposite side of the vertebral column.","confidence":1,"confidence_rate":1},{"cnt":[[245,1616],[1828,1616],[1828,1663],[245,1663]],"region":{"top_left_x":244,"top_left_y":1615,"width":1585,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92af4dbbf67a412e9b7a1ec5e9e86e24","type":"text","conversion_output":true,"text":"Stage 4: Any primary tumor with dissemination to distant lymph nodes, bone, bone marrow, liver, skin","text_display":"\n\nStage 4: Any primary tumor with dissemination to distant lymph nodes, bone, bone marrow, liver, skin","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[1059,1663],[1059,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1662,"width":816,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7395a659052449e0aa5ad8058eee961e","type":"text","conversion_output":true,"text":"and/or other organs (except as defined for Stage 4S).","text_display":" and/or other organs (except as defined for Stage 4S).","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1880,1749],[1880,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"141cd82e959c43bb8e1fd18ad0452b64","type":"text","conversion_output":true,"text":"Stage 4S: Localized primary tumor (as defined for Stage 1 or 2A or 2B), with dissemination limited to","text_display":"\n\nStage 4S: Localized primary tumor (as defined for Stage 1 or 2A or 2B), with dissemination limited to","confidence":0.99755859375,"confidence_rate":0.9999775746428119},{"cnt":[[245,1792],[1880,1792],[1880,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1636,"height":51},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33aaf624937e4c309969f5d95fd0d1f7","type":"text","conversion_output":true,"text":"liver, skin, and/or bone marrow (limited to infants \\(<1\\) year of age). Marrow involvement should be \\(<\\)","text_display":" liver, skin, and/or bone marrow (limited to infants \\(<1\\) year of age). Marrow involvement should be \\(<","confidence":0.9970703125,"confidence_rate":0.9999723212563202},{"cnt":[[247,1835],[1880,1835],[1880,1884],[247,1884]],"region":{"top_left_x":247,"top_left_y":1834,"width":1633,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30997c0bd1214903b8d9750f49e12dc7","type":"text","conversion_output":true,"text":"\\(10 \\%\\) of total nucleated cells identified as malignant on bone marrow biopsy or on marrow aspirate.","text_display":" 10 \\%\\) of total nucleated cells identified as malignant on bone marrow biopsy or on marrow aspirate.","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1188,1882],[1188,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1882,"width":945,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc5651e75f6140648dc5f5eee21725ce","type":"text","conversion_output":true,"text":"MIBG scan (if performed) should be negative in the marrow.","text_display":" MIBG scan (if performed) should be negative in the marrow.","confidence":1,"confidence_rate":1},{"cnt":[[243,1955],[941,1955],[941,2017],[243,2017]],"region":{"top_left_x":242,"top_left_y":1955,"width":700,"height":63},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c402c29923ca45e89fc03db37422de5e","type":"section_header","conversion_output":false,"children_ids":["86fb30e3a71c427090e9165b5b2b2e96"],"text":"","text_display":""},{"cnt":[[247,1959],[935,1959],[935,2013],[247,2013]],"region":{"top_left_x":247,"top_left_y":1959,"width":688,"height":55},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86fb30e3a71c427090e9165b5b2b2e96","type":"text","conversion_output":true,"parent_id":"c402c29923ca45e89fc03db37422de5e","text":"10.4 International Response Criteria \\({ }^{ 1 2 3 }\\)","text_display":"\n\n\\subsection*{10.4 International Response Criteria \\({ }^{ 1 2 3 }\\)}","confidence":0.99658203125,"confidence_rate":0.9999365978738969},{"cnt":[[245,2013],[1880,2013],[1880,2058],[245,2058]],"region":{"top_left_x":244,"top_left_y":2013,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc2da1e5ae5d4c7f9fb1390e3e1f0450","type":"text","conversion_output":true,"text":"Measurable tumor is defined as the product of the longest x widest perpendicular diameter. The third","text_display":"\n\nMeasurable tumor is defined as the product of the longest x widest perpendicular diameter. The third","confidence":0.9907307624816895,"confidence_rate":0.9999161074450615},{"cnt":[[245,2056],[1884,2056],[1884,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2056,"width":1641,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0eedf715f91b4fd78bbb941d302c3b38","type":"text","conversion_output":true,"text":"dimension is added when possible. Elevated catecholamine metabolite levels and tumor cell invasion of","text_display":" dimension is added when possible. 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Usually more than 1 cubic centimeter of viable tissue is needed for all these assays. Needle","text_display":" required. Usually more than 1 cubic centimeter of viable tissue is needed for all these assays. Needle","confidence":1,"confidence_rate":1},{"cnt":[[245,2056],[1880,2056],[1880,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2056,"width":1636,"height":48},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73f5a18122004ff88bc3fc16bc686ed5","type":"text","conversion_output":true,"text":"biopsies are not sufficient for histologic classification. The surgeon should remember that a significant","text_display":" biopsies are not sufficient for histologic classification. 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Frozen section examination of a small amount of tissue will verify","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1880,2144],[1880,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d1d5fe2f2814a83af984fbac460d5d4","type":"text","conversion_output":true,"text":"that viable neuroblastoma is being biopsied. The anesthesia time while awaiting frozen section analysis","text_display":" that viable neuroblastoma is being biopsied. 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Biopsy of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[1880,1087],[1880,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b72af74ea9f4787924224f7ec80971e","type":"text","conversion_output":true,"text":"primary tumor or an accessible metastatic site is acceptable. The goal of the biopsy procedure is to obtain","text_display":" primary tumor or an accessible metastatic site is acceptable. The goal of the biopsy procedure is to obtain","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1880,1130],[1880,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1636,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"433ca259b3ed4c8fbeb2d40c9d00629f","type":"text","conversion_output":true,"text":"enough tissue for a histopathological diagnosis as well as MYCN determination, cytogenetics, and other","text_display":" enough tissue for a histopathological diagnosis as well as MYCN determination, cytogenetics, and other","confidence":0.865234375,"confidence_rate":0.9986480655757384},{"cnt":[[245,1171],[1880,1171],[1880,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1170,"width":1636,"height":53},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f81d283a92cb4b859b7d42e8e5ea56b0","type":"text","conversion_output":true,"text":"biological studies. The surgeon should try to obtain at least one \\(cm ^{3}\\) of viable tumor tissue, if feasible,","text_display":" biological studies. The surgeon should try to obtain at least one \\(cm ^{3}\\) of viable tumor tissue, if feasible,","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1880,1216],[1880,1265],[245,1265]],"region":{"top_left_x":244,"top_left_y":1216,"width":1636,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7f634ab0b4e43b89b26ac2372c57cca","type":"text","conversion_output":true,"text":"according to the surgeon's judgment. Complete excision of the primary tumor can occasionally be","text_display":" according to the surgeon's judgment. Complete excision of the primary tumor can occasionally be","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[1880,1263],[1880,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1263,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cae12e8637747059242396b95c29b75","type":"text","conversion_output":true,"text":"performed if the tumor is easily resectable without a lengthy procedure or extensive dissection. However,","text_display":" performed if the tumor is easily resectable without a lengthy procedure or extensive dissection. However,","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1884,1306],[1884,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1641,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4df66a8904e445d83e925c37cb1f3d9","type":"text","conversion_output":true,"text":"a resection should not be undertaken if it might result in significant delay in the initiation of","text_display":" a resection should not be undertaken if it might result in significant delay in the initiation of","confidence":1,"confidence_rate":1},{"cnt":[[245,1349],[1880,1349],[1880,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1349,"width":1636,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aae074ed500c440c8fb45a0be5e4dbfd","type":"text","conversion_output":true,"text":"chemotherapy or great morbidity. In some institutions the diagnosis is established by finding","text_display":" chemotherapy or great morbidity. In some institutions the diagnosis is established by finding","confidence":1,"confidence_rate":1},{"cnt":[[245,1394],[1717,1394],[1717,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1394,"width":1473,"height":48},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afe5e552b2eb467894fb2899982e101b","type":"text","conversion_output":true,"text":"neuroblastoma in bone marrow specimens in conjunction with elevated urinary catecholamines.","text_display":" neuroblastoma in bone marrow specimens in conjunction with elevated urinary catecholamines.","confidence":1,"confidence_rate":1},{"cnt":[[243,1478],[917,1478],[917,1532],[243,1532]],"region":{"top_left_x":242,"top_left_y":1478,"width":676,"height":54},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f9db191a0ce4b18a4a976afa3639808","type":"section_header","conversion_output":false,"children_ids":["e9dad3f80a7a44e1aee16c71d3824929"],"text":"","text_display":""},{"cnt":[[247,1482],[913,1482],[913,1525],[247,1525]],"region":{"top_left_x":247,"top_left_y":1482,"width":667,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9dad3f80a7a44e1aee16c71d3824929","type":"text","conversion_output":true,"parent_id":"5f9db191a0ce4b18a4a976afa3639808","text":"13.4.3 Tumors with Intraspinal Extension","text_display":"\n\n\\subsection*{13.4.3 Tumors with Intraspinal Extension}","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1880,1525],[1880,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1636,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87f03a60efda4d23a7a59c652f8a56b7","type":"text","conversion_output":true,"text":"When the tumor approaches the spinal canal on imaging (see Section 16.2), a detailed examination must","text_display":"\n\nWhen the tumor approaches the spinal canal on imaging (see Section 16.2), a detailed examination must","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1880,1568],[1880,1613],[245,1613]],"region":{"top_left_x":244,"top_left_y":1568,"width":1636,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e86f108be924eebaa7cc7d53da0a7e1","type":"text","conversion_output":true,"text":"assess neurological function. The format for the examination, a modification of the ASCIA scale, is","text_display":" assess neurological function. The format for the examination, a modification of the ASCIA scale, is","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1880,1611],[1880,1661],[245,1661]],"region":{"top_left_x":244,"top_left_y":1611,"width":1636,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f62659e7a2a43818e2549ada9e7a8fc","type":"text","conversion_output":true,"text":"detailed in Appendix III and should be used to document the degree of neurologic dysfunction at","text_display":" detailed in Appendix III and should be used to document the degree of neurologic dysfunction at","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1244,1659],[1244,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1000,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"082dfa5f268f4b0480123ff7c26b64de","type":"text","conversion_output":true,"text":"diagnosis and at subsequent time points during and post-therapy.","text_display":" diagnosis and at subsequent time points during and post-therapy.","confidence":0.99951171875,"confidence_rate":0.9999929217569623},{"cnt":[[245,1745],[1880,1745],[1880,1792],[245,1792]],"region":{"top_left_x":244,"top_left_y":1744,"width":1636,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8bfc67b02124cfb8972f7ce7a8a5b9b","type":"text","conversion_output":true,"text":"Laminectomy should not be performed in patients who are neurologically asymptomatic. Patients with","text_display":"\n\nLaminectomy should not be performed in patients who are neurologically asymptomatic. Patients with","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1880,1788],[1880,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1636,"height":48},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b13c1dc951244058ba504ca604804df8","type":"text","conversion_output":true,"text":"symptomatic spinal cord compression secondary to intraspinal/epidural extension of neuroblastoma","text_display":" symptomatic spinal cord compression secondary to intraspinal/epidural extension of neuroblastoma","confidence":1,"confidence_rate":1},{"cnt":[[245,1833],[1880,1833],[1880,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1832,"width":1636,"height":48},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b5220f227cc4592a64b0dabca2f110d","type":"text","conversion_output":true,"text":"through a neural foramina may require laminectomy, or osteoplastic laminotomy at diagnosis to prevent","text_display":" through a neural foramina may require laminectomy, or osteoplastic laminotomy at diagnosis to prevent","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1880,1878],[1880,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1877,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75d55e31e36c43af9eab719260d73d56","type":"text","conversion_output":true,"text":"permanent paralysis. However, treatment with chemotherapy alone or chemotherapy and radiation","text_display":" permanent paralysis. However, treatment with chemotherapy alone or chemotherapy and radiation","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1880,1921],[1880,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1636,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"649d8bb9dd7f403288f398d0aa547767","type":"text","conversion_output":true,"text":"therapy will frequently be sufficient to rapidly reverse symptoms of cord compression. Therapeutic","text_display":" therapy will frequently be sufficient to rapidly reverse symptoms of cord compression. Therapeutic","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1880,1964],[1880,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1963,"width":1636,"height":51},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac1582c565764cf2bd0214e1d93a053e","type":"text","conversion_output":true,"text":"decisions in neuroblastoma patients with spinal cord compression should be made with the","text_display":" decisions in neuroblastoma patients with spinal cord compression should be made with the","confidence":1,"confidence_rate":1},{"cnt":[[245,2007],[1880,2007],[1880,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2006,"width":1636,"height":51},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e0c3beb65434a87a6b92fbab89aa432","type":"text","conversion_output":true,"text":"multidisciplinary involvement of the attending pediatric oncologist, general pediatric surgeon, and","text_display":" multidisciplinary involvement of the attending pediatric oncologist, general pediatric surgeon, and","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[612,2054],[612,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2053,"width":369,"height":47},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0df726bdb6a464ebdf19fd78f1a5039","type":"text","conversion_output":true,"text":"pediatric neurosurgeon.","text_display":" pediatric neurosurgeon.","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1880,2097],[1880,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d845c8c49f3b4267a0d10b3eef5bee3f","type":"text","conversion_output":true,"text":"If neurologic deterioration occurs during chemotherapy, neurosurgical evaluation should be sought and","text_display":"\nIf neurologic deterioration occurs during chemotherapy, neurosurgical evaluation should be sought and","confidence":0.9951171875,"confidence_rate":0.999953823968252},{"cnt":[[245,2140],[1880,2140],[1880,2187],[245,2187]],"region":{"top_left_x":244,"top_left_y":2139,"width":1636,"height":49},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7893dd511a794a6589521fe601b0f258","type":"text","conversion_output":true,"text":"operative decompression strongly considered. Appropriate to the degree of neurological impairment, the","text_display":" operative decompression strongly considered. Appropriate to the degree of neurological impairment, the","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1880,2183],[1880,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2182,"width":1636,"height":49},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af7bbb86ac9b4db492a377d4dcb52923","type":"text","conversion_output":true,"text":"treating physicians may decide that operative neurosurgical decompression is indicated under these","text_display":" treating physicians may decide that operative neurosurgical decompression is indicated under these","confidence":1,"confidence_rate":1},{"cnt":[[245,2226],[1880,2226],[1880,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2225,"width":1636,"height":51},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"294105bd8b3f4f009c12775c482e092a","type":"text","conversion_output":true,"text":"circumstances. If feasible, the neurosurgeon should perform an osteoplastic laminotomy, with secure","text_display":" circumstances. If feasible, the neurosurgeon should perform an osteoplastic laminotomy, with secure","confidence":1,"confidence_rate":1},{"cnt":[[245,2271],[1880,2271],[1880,2318],[245,2318]],"region":{"top_left_x":244,"top_left_y":2270,"width":1636,"height":49},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"454ab6a4e1bc40c8a134dc2ad9790374","type":"text","conversion_output":true,"text":"replacement of the laminae after decompression has been accomplished. Operative details will be","text_display":" replacement of the laminae after decompression has been accomplished. Operative details will be","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[578,2316],[578,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2316,"width":334,"height":41},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"525558a491464d278c27bfa56526ada6","type":"text","conversion_output":true,"text":"recorded in the RDE.","text_display":" recorded in the RDE.","confidence":1,"confidence_rate":1},{"cnt":[[245,2402],[1884,2402],[1884,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2401,"width":1641,"height":51},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f45e591ed09546fdba0337a77ad78f92","type":"text","conversion_output":true,"text":"Assessment of neurological function will be performed prior to start of treatment, after 2 cycles of","text_display":"\n\nAssessment of neurological function will be performed prior to start of treatment, after 2 cycles of","confidence":1,"confidence_rate":1},{"cnt":[[245,2447],[1880,2447],[1880,2494],[245,2494]],"region":{"top_left_x":244,"top_left_y":2447,"width":1636,"height":48},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08bbb8106aec4a55821b5dff7bb52a68","type":"text","conversion_output":true,"text":"inductions, end-induction therapy, end consolidation therapy and end of cisRA therapy for all patients","text_display":" inductions, end-induction therapy, end consolidation therapy and end of cisRA therapy for all patients","confidence":1,"confidence_rate":1},{"cnt":[[1749,2585],[1876,2585],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2584,"width":128,"height":44},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"167244db79d742dd823da59d51fd1d49","type":"page_info","conversion_output":false,"text":"Page 82","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-083","page":83,"lines":[{"cnt":[[247,125],[614,125],[614,187],[247,187]],"region":{"top_left_x":247,"top_left_y":124,"width":368,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"6598f78580684ab68001a5d8490fdcd0","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,129],[1648,129],[1648,163],[653,163]],"region":{"top_left_x":653,"top_left_y":128,"width":995,"height":36},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"018844246cee4e73aced7a0d7ce67904","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.3868687993426345,"confidence_rate":0.9881993100194835},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6c6deb02faf4b1a89d6bbfa6628d732","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,200],[651,200],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":199,"width":321,"height":31},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"265d9276360c410799c83e82ad19f6f9","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,254],[1878,254],[1878,299],[245,299]],"region":{"top_left_x":244,"top_left_y":253,"width":1634,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5624cdc7a8d433b9b8dd67e5e5bfbcb","type":"text","conversion_output":true,"text":"with intraspinal extension of tumors (see Section 7.0). Neurologic and orthopedic evaluations will be","text_display":"\nwith intraspinal extension of tumors (see Section 7.0). Neurologic and orthopedic evaluations will be","confidence":1,"confidence_rate":1},{"cnt":[[245,299],[1878,299],[1878,342],[245,342]],"region":{"top_left_x":244,"top_left_y":298,"width":1634,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5becd4c353e04622986b0bbeb4b79ca2","type":"text","conversion_output":true,"text":"a routine part of off therapy follow-up for patients with intraspinal extension of tumors, and will be","text_display":" a routine part of off therapy follow-up for patients with intraspinal extension of tumors, and will be","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1878,339],[1878,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1634,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56b86bd6c8f941a38347d33a72599a88","type":"text","conversion_output":true,"text":"performed at \\(6,12,24\\), and 36 months post therapy, and then annually thereafter. Orthopedic","text_display":" performed at \\(6,12,24\\), and 36 months post therapy, and then annually thereafter. Orthopedic","confidence":1,"confidence_rate":1},{"cnt":[[245,385],[1876,385],[1876,428],[245,428]],"region":{"top_left_x":244,"top_left_y":384,"width":1632,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2b6a1c2d8ba48e19396e0897293c1e0","type":"text","conversion_output":true,"text":"evaluation will include assessment of scoliosis and of extremity deformity by upright spine x-ray at these","text_display":" evaluation will include assessment of scoliosis and of extremity deformity by upright spine x-ray at these","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,430],[724,430],[724,473],[245,473]],"region":{"top_left_x":244,"top_left_y":429,"width":481,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"718c34294baf4c36932be95f6d235e11","type":"text","conversion_output":true,"text":"time points (see Appendix III).","text_display":" time points (see Appendix III).","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1330,520],[1330,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":1086,"height":47},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04d1f3e07b894dee851c286baba7a92c","type":"section_header","conversion_output":false,"children_ids":["8c4e9c7785b24269aa554f52f392ee30"],"text":"","text_display":""},{"cnt":[[249,522],[1326,522],[1326,561],[249,561]],"region":{"top_left_x":249,"top_left_y":522,"width":1077,"height":39},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c4e9c7785b24269aa554f52f392ee30","type":"text","conversion_output":true,"parent_id":"04d1f3e07b894dee851c286baba7a92c","text":"13.4.4 Operative management of primary tumors after chemotherapy","text_display":"\n\n\\subsection*{13.4.4 Operative management of primary tumors after chemotherapy}","confidence":1,"confidence_rate":1},{"cnt":[[247,563],[1876,563],[1876,608],[247,608]],"region":{"top_left_x":247,"top_left_y":562,"width":1629,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8e060cc1e334416b692f86e6e5c2524","type":"text","conversion_output":true,"text":"The majority of patients will undergo resection of the primary tumor after initial induction chemotherapy.","text_display":"\n\nThe majority of patients will undergo resection of the primary tumor after initial induction chemotherapy.","confidence":1,"confidence_rate":1},{"cnt":[[247,610],[1880,610],[1880,651],[247,651]],"region":{"top_left_x":247,"top_left_y":610,"width":1633,"height":41},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89eba263e77341c98ae162431c8445a8","type":"text","conversion_output":true,"text":"Surgical resection should be performed when the \\(ANC >500 / \\mu L\\) and the patient is medically stable after","text_display":" Surgical resection should be performed when the \\(ANC >500 / \\mu L\\) and the patient is medically stable after","confidence":0.98828125,"confidence_rate":0.9998966022252864},{"cnt":[[247,653],[1876,653],[1876,696],[247,696]],"region":{"top_left_x":247,"top_left_y":653,"width":1629,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86d7538435314eed89e5ad2957ecbea9","type":"text","conversion_output":true,"text":"Cycle 5 of Induction. This is to allow maximal tumor reduction by chemotherapy prior to resection and","text_display":" Cycle 5 of Induction. This is to allow maximal tumor reduction by chemotherapy prior to resection and","confidence":1,"confidence_rate":1},{"cnt":[[247,696],[1880,696],[1880,741],[247,741]],"region":{"top_left_x":247,"top_left_y":696,"width":1633,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24680fe627b54117a43efd67bee97864","type":"text","conversion_output":true,"text":"to reduce vascularity. Surgical resection may be performed later in Induction, if necessary, but must","text_display":" to reduce vascularity. Surgical resection may be performed later in Induction, if necessary, but must","confidence":1,"confidence_rate":1},{"cnt":[[247,741],[1863,741],[1863,784],[247,784]],"region":{"top_left_x":247,"top_left_y":741,"width":1616,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fb8a5fd76af40b0809c3ab98e676d42","type":"text","conversion_output":true,"text":"occur prior to Consolidation. Surgical scheduling SHOULD AVOID DELAYS OF MORE THAN SIX","text_display":" occur prior to Consolidation. Surgical scheduling SHOULD AVOID DELAYS OF MORE THAN SIX","confidence":1,"confidence_rate":1},{"cnt":[[247,786],[1111,786],[1111,823],[247,823]],"region":{"top_left_x":247,"top_left_y":786,"width":864,"height":37},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95e4c2f8fdb449b2b51699534b2edcb1","type":"text","conversion_output":true,"text":"WEEKS BETWEEN CHEMOTHERAPY CYCLES.","text_display":" WEEKS BETWEEN CHEMOTHERAPY CYCLES.","confidence":1,"confidence_rate":1},{"cnt":[[247,885],[1878,885],[1878,930],[247,930]],"region":{"top_left_x":247,"top_left_y":885,"width":1631,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9061a85d2e704fc3b405d937565a5c17","type":"text","conversion_output":true,"text":"The goal of delayed surgery is gross total resection of residual tumor in the primary site as well as tumor","text_display":"\n\nThe goal of delayed surgery is gross total resection of residual tumor in the primary site as well as tumor","confidence":1,"confidence_rate":1},{"cnt":[[247,928],[1878,928],[1878,971],[247,971]],"region":{"top_left_x":247,"top_left_y":928,"width":1631,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99a550d164ee4930b402fecba2c85657","type":"text","conversion_output":true,"text":"in areas of regional dissemination (usually lymph nodes). Resection with microscopically negative","text_display":" in areas of regional dissemination (usually lymph nodes). Resection with microscopically negative","confidence":1,"confidence_rate":1},{"cnt":[[247,971],[1878,971],[1878,1016],[247,1016]],"region":{"top_left_x":247,"top_left_y":971,"width":1631,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ccd4f9ae0ce4a989e1f78cfd6d3efc0","type":"text","conversion_output":true,"text":"margins may not be feasible because of proximity to major vascular structures and the spine. Instead, the","text_display":" margins may not be feasible because of proximity to major vascular structures and the spine. Instead, the","confidence":1,"confidence_rate":1},{"cnt":[[247,1016],[1876,1016],[1876,1059],[247,1059]],"region":{"top_left_x":247,"top_left_y":1016,"width":1629,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7514e256a13a4fa2be06d0629f5cd923","type":"text","conversion_output":true,"text":"surgeon should concentrate on removing, as completely as possible, all gross disease. It is acceptable,","text_display":" surgeon should concentrate on removing, as completely as possible, all gross disease. It is acceptable,","confidence":1,"confidence_rate":1},{"cnt":[[247,1061],[1876,1061],[1876,1102],[247,1102]],"region":{"top_left_x":247,"top_left_y":1061,"width":1629,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5dbb128282d64d97a9d491fa40dbebd1","type":"text","conversion_output":true,"text":"and often necessary, to incise the tumor and remove it in a segmental fashion. Titianium clips should be","text_display":" and often necessary, to incise the tumor and remove it in a segmental fashion. Titianium clips should be","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[247,1104],[1878,1104],[1878,1145],[247,1145]],"region":{"top_left_x":247,"top_left_y":1104,"width":1631,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b374c75dfe1c43509ee8793f48f782d4","type":"text","conversion_output":true,"text":"used to mark all areas of residual disease. All attempts should be made to preserve organs, especially the","text_display":" used to mark all areas of residual disease. All attempts should be made to preserve organs, especially the","confidence":1,"confidence_rate":1},{"cnt":[[247,1147],[1878,1147],[1878,1192],[247,1192]],"region":{"top_left_x":247,"top_left_y":1147,"width":1631,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6da4666fb7b345299a18ceb81c631454","type":"text","conversion_output":true,"text":"kidney. Rarely, nephrectomy may be necessary for complete tumor removal but this should only be","text_display":" kidney. Rarely, nephrectomy may be necessary for complete tumor removal but this should only be","confidence":1,"confidence_rate":1},{"cnt":[[245,1192],[1880,1192],[1880,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1192,"width":1636,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"612846e0c8d3441fb36d5ea5fa1a01de","type":"text","conversion_output":true,"text":"planned if the involved kidney has greatly diminished function. If pre-operatively a nephrectomy is being","text_display":" planned if the involved kidney has greatly diminished function. If pre-operatively a nephrectomy is being","confidence":1,"confidence_rate":1},{"cnt":[[247,1233],[1878,1233],[1878,1278],[247,1278]],"region":{"top_left_x":247,"top_left_y":1233,"width":1631,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6d2d75db5e8490c871a17549ae2415a","type":"text","conversion_output":true,"text":"considered, then a differential GFR should be obtained to determine what the renal function will be in the","text_display":" considered, then a differential GFR should be obtained to determine what the renal function will be in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1280],[1878,1280],[1878,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1280,"width":1634,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e75352a95136468db28eeeb6b07dbc1c","type":"text","conversion_output":true,"text":"remaining kidney. This is extremely important because carboplatin is used for consolidation and toxicity","text_display":" remaining kidney. This is extremely important because carboplatin is used for consolidation and toxicity","confidence":1,"confidence_rate":1},{"cnt":[[245,1315],[1880,1315],[1880,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1314,"width":1636,"height":55},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82f3595662774d86a32e90d45774b57e","type":"text","conversion_output":true,"text":"may be greater for patients with a GFR \\(<100 ml / min / 1.73 m^{2}\\). The surgical committee of the Children's","text_display":" may be greater for patients with a GFR \\(<100 ml / min / 1.73 m^{2}\\). The surgical committee of the Children's","confidence":0.6925327777862549,"confidence_rate":0.9970174671066598},{"cnt":[[245,1366],[1390,1366],[1390,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1366,"width":1147,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0270d2e99194ec0b3ecf98b257b130d","type":"text","conversion_output":true,"text":"Oncology Group strongly recommends kidney preservation when feasible.","text_display":" Oncology Group strongly recommends kidney preservation when feasible.","confidence":1,"confidence_rate":1},{"cnt":[[245,1457],[1878,1457],[1878,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1456,"width":1634,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"372c55fb39674f7ea93541dd212d67c3","type":"text","conversion_output":true,"text":"It is vital that the operating surgeon dictate a detailed operative note, which should include: the","text_display":"\n\nIt is vital that the operating surgeon dictate a detailed operative note, which should include: the","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1543],[245,1543]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":44},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f492e045a4d540c784d23a813c028f3d","type":"text","conversion_output":true,"text":"completeness of resection, areas of residual disease, estimated blood loss, and any operative complication","text_display":" completeness of resection, areas of residual disease, estimated blood loss, and any operative complication","confidence":1,"confidence_rate":1},{"cnt":[[245,1543],[1880,1543],[1880,1588],[245,1588]],"region":{"top_left_x":244,"top_left_y":1542,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ce9014f3f444694b5c73b2d093dda51","type":"text","conversion_output":true,"text":"such as identification of injury to adjacent structures, removal of normal organs, renal injury and vascular","text_display":" such as identification of injury to adjacent structures, removal of normal organs, renal injury and vascular","confidence":1,"confidence_rate":1},{"cnt":[[245,1586],[350,1586],[350,1631],[245,1631]],"region":{"top_left_x":244,"top_left_y":1585,"width":107,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d588913040504eb39872f0e15728f034","type":"text","conversion_output":true,"text":"injury.","text_display":" injury.","confidence":1,"confidence_rate":1},{"cnt":[[245,1676],[1824,1676],[1824,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1675,"width":1581,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6607bf4bd754998b59a5f954d7fb5e3","type":"text","conversion_output":true,"text":"Surgical resection of residual disease following HSCT is not encouraged, unless it would alter therapy.","text_display":"\n\nSurgical resection of residual disease following HSCT is not encouraged, unless it would alter therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1760],[1025,1760],[1025,1809],[245,1809]],"region":{"top_left_x":244,"top_left_y":1759,"width":781,"height":50},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97e4e3cdcc4b47ccb5b685faf39519fa","type":"section_header","conversion_output":false,"children_ids":["01cb80a464bf469f89d064d824baebb7"],"text":"","text_display":""},{"cnt":[[249,1762],[1025,1762],[1025,1807],[249,1807]],"region":{"top_left_x":249,"top_left_y":1761,"width":776,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01cb80a464bf469f89d064d824baebb7","type":"text","conversion_output":true,"parent_id":"97e4e3cdcc4b47ccb5b685faf39519fa","text":"13.5 Management of Surgical Complications","text_display":"\n\n\\subsection*{13.5 Management of Surgical Complications}","confidence":1,"confidence_rate":1},{"cnt":[[245,1848],[827,1848],[827,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1847,"width":584,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"deccb619f72c4a689c419aa8aa7d3603","type":"section_header","conversion_output":false,"children_ids":["816ad0b56a444e49b939fdfaec3aee78"],"text":"","text_display":""},{"cnt":[[249,1852],[825,1852],[825,1893],[249,1893]],"region":{"top_left_x":249,"top_left_y":1851,"width":576,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"816ad0b56a444e49b939fdfaec3aee78","type":"text","conversion_output":true,"parent_id":"deccb619f72c4a689c419aa8aa7d3603","text":"13.5.1 Intraoperative Complications","text_display":"\n\n\\subsection*{13.5.1 Intraoperative Complications}","confidence":1,"confidence_rate":1},{"cnt":[[247,1904],[1878,1904],[1878,1946],[247,1946]],"region":{"top_left_x":247,"top_left_y":1903,"width":1631,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a54aa91792ce49aca9097f9ef3acf5a3","type":"text","conversion_output":true,"text":"Intraoperative complications are site-dependent. Major hemorrhage from either venous or arterial","text_display":"\n\nIntraoperative complications are site-dependent. Major hemorrhage from either venous or arterial","confidence":1,"confidence_rate":1},{"cnt":[[247,1946],[1880,1946],[1880,1992],[247,1992]],"region":{"top_left_x":247,"top_left_y":1946,"width":1633,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29fdcb77e9354279a9e6f7bbd5aeb29e","type":"text","conversion_output":true,"text":"structures is always possible with these infiltrative tumors. The principles of vascular surgery, including","text_display":" structures is always possible with these infiltrative tumors. The principles of vascular surgery, including","confidence":1,"confidence_rate":1},{"cnt":[[247,1989],[1880,1989],[1880,2035],[247,2035]],"region":{"top_left_x":247,"top_left_y":1989,"width":1633,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"380c01ac6de146c1b2ddd59ad23fd86a","type":"text","conversion_output":true,"text":"proximal and distal control, pertain. Appropriate intraoperative vascular consultation should be sought if","text_display":" proximal and distal control, pertain. Appropriate intraoperative vascular consultation should be sought if","confidence":1,"confidence_rate":1},{"cnt":[[245,2035],[1878,2035],[1878,2078],[245,2078]],"region":{"top_left_x":244,"top_left_y":2034,"width":1634,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b097458410c2402db7a4e56b1e115fdd","type":"text","conversion_output":true,"text":"necessary. Crucial vessels like the carotid, subclavian, hepatic, superior mesenteric or renal arteries","text_display":" necessary. Crucial vessels like the carotid, subclavian, hepatic, superior mesenteric or renal arteries","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1878,2075],[1878,2121],[245,2121]],"region":{"top_left_x":244,"top_left_y":2075,"width":1634,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f6388268d8543b0aaea471a79406f5a","type":"text","conversion_output":true,"text":"should be repaired and flow restored even if bypass grafting is required. Nerve injuries may also be","text_display":" should be repaired and flow restored even if bypass grafting is required. Nerve injuries may also be","confidence":1,"confidence_rate":1},{"cnt":[[245,2121],[1210,2121],[1210,2168],[245,2168]],"region":{"top_left_x":244,"top_left_y":2120,"width":966,"height":48},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99a685676d46409c8f9a96f63e9d882d","type":"text","conversion_output":true,"text":"incurred and should be primarily repaired using magnification.","text_display":" incurred and should be primarily repaired using magnification.","confidence":1,"confidence_rate":1},{"cnt":[[245,2206],[834,2206],[834,2254],[245,2254]],"region":{"top_left_x":244,"top_left_y":2206,"width":590,"height":48},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2476ae5311749179cea746b5aabf6b7","type":"section_header","conversion_output":false,"children_ids":["249bbdb7898144cf8bed84e28da1efa5"],"text":"","text_display":""},{"cnt":[[249,2209],[831,2209],[831,2254],[249,2254]],"region":{"top_left_x":249,"top_left_y":2208,"width":583,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"249bbdb7898144cf8bed84e28da1efa5","type":"text","conversion_output":true,"parent_id":"f2476ae5311749179cea746b5aabf6b7","text":"13.5.2 Post-operative Complications","text_display":"\n\n\\subsection*{13.5.2 Post-operative Complications}","confidence":1,"confidence_rate":1},{"cnt":[[247,2260],[1878,2260],[1878,2305],[247,2305]],"region":{"top_left_x":247,"top_left_y":2260,"width":1631,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"894f28020c4b4377bfd43ae87f5b159f","type":"text","conversion_output":true,"text":"This topic is too broad for simple discussion. Generally, large neuroblastoma resections result in","text_display":"\n\nThis topic is too broad for simple discussion. Generally, large neuroblastoma resections result in","confidence":1,"confidence_rate":1},{"cnt":[[245,2305],[1880,2305],[1880,2348],[245,2348]],"region":{"top_left_x":244,"top_left_y":2305,"width":1636,"height":44},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aaf9b990f0694bb78905bd9401558f28","type":"text","conversion_output":true,"text":"significant third space losses and require vigorous fluid replacement. Because of this fluid requirement","text_display":" significant third space losses and require vigorous fluid replacement. Because of this fluid requirement","confidence":1,"confidence_rate":1},{"cnt":[[245,2350],[1880,2350],[1880,2393],[245,2393]],"region":{"top_left_x":244,"top_left_y":2350,"width":1636,"height":44},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"540dbfb88c0947449fda24aab92bb1ab","type":"text","conversion_output":true,"text":"patients may require significant periods of post-operative ventilation. The need for post-operative","text_display":" patients may require significant periods of post-operative ventilation. The need for post-operative","confidence":1,"confidence_rate":1},{"cnt":[[245,2393],[1878,2393],[1878,2438],[245,2438]],"region":{"top_left_x":244,"top_left_y":2393,"width":1634,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e4d5733236f46489aee5a8886160488","type":"text","conversion_output":true,"text":"monitoring in an intensive care environment should be anticipated. Acute and long-term complications","text_display":" monitoring in an intensive care environment should be anticipated. 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If","text_display":" www.preanalytix.com; or through the US vendor VWR, catalog \\#77776-026; www.vwrsp.com). 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Three","text_display":"\nThe central intent of these studies is to assess survivin as a tumor antigen in neuroblastoma. Three","confidence":1,"confidence_rate":1},{"cnt":[[245,1783],[1880,1783],[1880,1828],[245,1828]],"region":{"top_left_x":244,"top_left_y":1783,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8baa196f43084027b5d1fd65aae5045e","type":"text","conversion_output":true,"text":"immunoassays are available to these studies to measure functional cellular and antitumor","text_display":" immunoassays are available to these studies to measure functional cellular and antitumor","confidence":1,"confidence_rate":1},{"cnt":[[245,1822],[1880,1822],[1880,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1821,"width":1636,"height":55},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6046b5d8625746d2bd4497b95f6cc4fe","type":"text","conversion_output":true,"text":"immunity \\({ }^{110,127,128}\\). These assays depend on the ability to isolate and utilize autologous antigen presenting","text_display":" immunity \\({ }^{110,127,128}\\). These assays depend on the ability to isolate and utilize autologous antigen presenting","confidence":0.9990234375,"confidence_rate":0.9999921837133647},{"cnt":[[245,1873],[1880,1873],[1880,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1873,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"216f6f989c9b417aa6c27a936c0701f3","type":"text","conversion_output":true,"text":"cells (APCs) to activate and expand antigen-specific T cells. We have used a system of RNA transfection","text_display":" cells (APCs) to activate and expand antigen-specific T cells. 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Routine assays","text_display":" using ELISPOT or target cell cytolysis, and detect antigen specific CTL using tetramers. Routine assays","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[1880,2269],[1880,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2268,"width":1636,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f9a5698574d4489a76bdf4f4d7a8328","type":"text","conversion_output":true,"text":"necessary for these assessments have been established in the lab and the Penn Human Immunology Core","text_display":" necessary for these assessments have been established in the lab and the Penn Human Immunology Core","confidence":1,"confidence_rate":1},{"cnt":[[245,2307],[1880,2307],[1880,2359],[245,2359]],"region":{"top_left_x":244,"top_left_y":2307,"width":1636,"height":52},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c0424ad91d5498083ee7847f81c6403","type":"text","conversion_output":true,"text":"(HIC) \\({ }^{110,127}\\). These assays include: (i) Flow cytometric T cell assays using monoclonal antibodies and","text_display":" (HIC) \\({ }^{110,127}\\). These assays include: (i) Flow cytometric T cell assays using monoclonal antibodies and","confidence":0.7548828125,"confidence_rate":0.9977348857275423},{"cnt":[[245,2355],[1880,2355],[1880,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2354,"width":1636,"height":48},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78e546af16f045859f69a10618c8c582","type":"text","conversion_output":true,"text":"HLA-A2/peptide tetramer complexes, (ii) ELISPOT assay for cytokine release from single peptide-","text_display":" HLA-A2/peptide tetramer complexes, (ii) ELISPOT assay for cytokine release from single peptide","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,2402],[1880,2402],[1880,2447],[245,2447]],"region":{"top_left_x":244,"top_left_y":2401,"width":1636,"height":47},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd63cbc47a9a47c4bd22f946c5624801","type":"text","conversion_output":true,"text":"specific T cells, and (iii) T cell cytotoxicity assays in response to survivin expressing targets. This","text_display":"specific T cells, and (iii) T cell cytotoxicity assays in response to survivin expressing targets. This","confidence":0.8125913143157959,"confidence_rate":0.9982721030005132},{"cnt":[[245,2445],[1880,2445],[1880,2490],[245,2490]],"region":{"top_left_x":244,"top_left_y":2444,"width":1636,"height":47},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e41608bb870e425bb82d3cab4c105476","type":"text","conversion_output":true,"text":"combination of immunoassessment assays will permit the evaluation of whether survivin-specific CD8+","text_display":" combination of immunoassessment assays will permit the evaluation of whether survivin-specific CD8+","confidence":1,"confidence_rate":1},{"cnt":[[1749,2582],[1876,2582],[1876,2628],[1749,2628]],"region":{"top_left_x":1748,"top_left_y":2582,"width":128,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74c87f80913c424d942b0ac2d89bc57e","type":"page_info","conversion_output":false,"text":"Page 93","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-094","page":94,"lines":[{"cnt":[[247,125],[614,125],[614,187],[247,187]],"region":{"top_left_x":247,"top_left_y":124,"width":368,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"799f386cb45b47a1b6501aea4d154c00","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,129],[1648,129],[1648,163],[653,163]],"region":{"top_left_x":653,"top_left_y":128,"width":995,"height":36},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8408c45f52244e8c9d3b87f9ecf60324","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.3872335437056247,"confidence_rate":0.9882109506727085},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb4fc2903ba44aa287fb784f45707059","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,198],[651,198],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":197,"width":321,"height":33},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7e97861e78a34d49b9c28f76bbc0a8cb","type":"text","conversion_output":true,"text":"Children's Oncology Group","text_display":"\n\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[245,254],[1876,254],[1876,299],[245,299]],"region":{"top_left_x":244,"top_left_y":253,"width":1632,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0f96e5257024019a129ea2a0b6a2e1e","type":"text","conversion_output":true,"text":"cells in patients both before after HSCT can be directly enumerated by peptide/MHC tetramers,","text_display":"\ncells in patients both before after HSCT can be directly enumerated by peptide/MHC tetramers,","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1878,296],[1878,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1634,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9a957cab6ba434998f152a6c1195bff","type":"text","conversion_output":true,"text":"proliferate and secrete IFN-gamma, and possess phenotypic and functional characteristics of tumor-lytic","text_display":" proliferate and secrete IFN-gamma, and possess phenotypic and functional characteristics of tumor-lytic","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[466,339],[466,380],[245,380]],"region":{"top_left_x":244,"top_left_y":339,"width":223,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b473ddad13694157bacbd4c0849a5619","type":"text","conversion_output":true,"text":"CD8+ T cells.","text_display":" CD8+ T cells.","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1878,430],[1878,473],[245,473]],"region":{"top_left_x":244,"top_left_y":429,"width":1634,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f850cd4999284ac1875466129981a5d3","type":"text","conversion_output":true,"text":"We have used HLA-A2/survivin1M2 tetramer to detect survivin-specific CD8+ CTL in HLA-A2+","text_display":"\n\nWe have used HLA-A2/survivin1M2 tetramer to detect survivin-specific CD8+ CTL in HLA-A2+","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,473],[1880,473],[1880,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1636,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74ae1b96bf86444c82b17fdc51988194","type":"text","conversion_output":true,"text":"patients (about half of patients will be A2+). These cells can be detected in the T cell samples collected at","text_display":" patients (about half of patients will be A2+). These cells can be detected in the T cell samples collected at","confidence":0.8978136590400254,"confidence_rate":0.9990548965510756},{"cnt":[[245,516],[1880,516],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c326955cc804d57929467775840a71d","type":"text","conversion_output":true,"text":"diagnosis, and we can use RNA-transfected CD40-B cells as APC to expand anti-tumor CD8+ T cells","text_display":" diagnosis, and we can use RNA-transfected CD40-B cells as APC to expand anti-tumor CD8+ T cells","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb806011112a49daafa4454e5020d896","type":"text","conversion_output":true,"text":"from patient samples. We will compare the numbers of survivin+ CTL generated using total autologous","text_display":" from patient samples. We will compare the numbers of survivin+ CTL generated using total autologous","confidence":0.990234375,"confidence_rate":0.9999056427072339},{"cnt":[[245,604],[1880,604],[1880,649],[245,649]],"region":{"top_left_x":244,"top_left_y":603,"width":1636,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6cb82381c134d5daa8ad89b13b8c2e2","type":"text","conversion_output":true,"text":"tumor RNA transfected into CD40-B cells to CTL generated using survivin mRNA. From the initial","text_display":" tumor RNA transfected into CD40-B cells to CTL generated using survivin mRNA. From the initial","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1880,649],[1880,694],[245,694]],"region":{"top_left_x":244,"top_left_y":648,"width":1636,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f117db8c536640b4903e4a2d444beb2d","type":"text","conversion_output":true,"text":"sample, CD40-B will be generated and electroporated with total autologous tumor RNA or survivin","text_display":" sample, CD40-B will be generated and electroporated with total autologous tumor RNA or survivin","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1880,692],[1880,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"feb02ac3127d4a14b6cace72b79de6a6","type":"text","conversion_output":true,"text":"mRNA. After coculture with autologous patient PBMC for one week, tetramer analysis will be","text_display":" mRNA. After coculture with autologous patient PBMC for one week, tetramer analysis will be","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1878,735],[1878,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1634,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba5db0536c0e40d79ee3190c167ef7da","type":"text","conversion_output":true,"text":"performed. Survivin-specific CD8+ CTL will be measured using our HLA-A2/survivin1M2 tetramer,","text_display":" performed. Survivin-specific CD8+ CTL will be measured using our HLA-A2/survivin1M2 tetramer,","confidence":1,"confidence_rate":1},{"cnt":[[245,780],[1880,780],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":779,"width":1636,"height":49},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3cb5f46b79154bc887af79c85daf3300","type":"text","conversion_output":true,"text":"comparing the percentage of CD8+/tetramer+ cells in cultures stimulated with either survivin mRNA or","text_display":" comparing the percentage of CD8+/tetramer+ cells in cultures stimulated with either survivin mRNA or","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1880,825],[1880,868],[245,868]],"region":{"top_left_x":244,"top_left_y":825,"width":1636,"height":43},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38450a2540f146d2a2df2e25b1925f03","type":"text","conversion_output":true,"text":"total tumor RNA, with GFP-stimulated cultures serving as negative controls. We will measure anti-tumor","text_display":" total tumor RNA, with GFP-stimulated cultures serving as negative controls. We will measure anti-tumor","confidence":1,"confidence_rate":1},{"cnt":[[245,862],[1880,862],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":861,"width":1636,"height":53},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"538bca36f1a94670922c921606398f07","type":"text","conversion_output":true,"text":"CTL cytotoxicty using the standard chromium \\({ }^{51}\\)-release assay. For cytotoxicity assays, HLA-matched","text_display":" CTL cytotoxicty using the standard chromium \\({ }^{51}\\)-release assay. For cytotoxicity assays, HLA-matched","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1880,911],[1880,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1636,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"813f231e79004bee90dd2d76846e0ed8","type":"text","conversion_output":true,"text":"allogenic cell lines will be used as targets, with HLA-mismatched neuroblastoma cells as negative control","text_display":" allogenic cell lines will be used as targets, with HLA-mismatched neuroblastoma cells as negative control","confidence":1,"confidence_rate":1},{"cnt":[[245,950],[1613,950],[1613,999],[245,999]],"region":{"top_left_x":244,"top_left_y":949,"width":1370,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c6367ba7a124ea5baacb1405942a4b1","type":"text","conversion_output":true,"text":"targets. We will also use the CD107a mobilization assay as a marker of CTL function \\({ }^{111}\\).","text_display":" targets. We will also use the CD107a mobilization assay as a marker of CTL function \\({ }^{111}\\).","confidence":1,"confidence_rate":1},{"cnt":[[245,1083],[1613,1083],[1613,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1082,"width":1370,"height":55},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2aa0f333348a4b85b3f1babd1881543c","type":"section_header","conversion_output":false,"children_ids":["1e1d1f68144443a38af13570de85f6d7"],"text":"","text_display":""},{"cnt":[[249,1087],[1609,1087],[1609,1130],[249,1130]],"region":{"top_left_x":249,"top_left_y":1087,"width":1361,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e1d1f68144443a38af13570de85f6d7","type":"text","conversion_output":true,"parent_id":"2aa0f333348a4b85b3f1babd1881543c","text":"16.0 IMAGING STUDIES REQUIRED AND GUIDELINES FOR OBTAINING","text_display":"\n\n\\subsection*{16.0 IMAGING STUDIES REQUIRED AND GUIDELINES FOR OBTAINING}","confidence":1,"confidence_rate":1},{"cnt":[[380,1211],[380,1164],[1775,1167],[1775,1214]],"region":{"top_left_x":380,"top_left_y":1164,"width":1395,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b05344d250664fff96a07f9f68c30af5","type":"text","conversion_output":true,"text":"Timing of protocol therapy administration, response assessment studies, and surgical","text_display":"\n\nTiming of protocol therapy administration, response assessment studies, and surgical","confidence":1,"confidence_rate":1},{"cnt":[[382,1212],[1775,1212],[1775,1257],[382,1257]],"region":{"top_left_x":382,"top_left_y":1211,"width":1393,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa5c35c749fe4cd09cf0d31b06c28afb","type":"text","conversion_output":true,"text":"interventions are based on schedules derived from the experimental design or on","text_display":" interventions are based on schedules derived from the experimental design or on","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[380,1255],[1775,1255],[1775,1300],[380,1300]],"region":{"top_left_x":380,"top_left_y":1254,"width":1395,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6c5b47496504c4798ac25ab8015e2e2","type":"text","conversion_output":true,"text":"established standards of care. Minor unavoidable departures (up to 72 hours) from","text_display":" established standards of care. Minor unavoidable departures (up to 72 hours) from","confidence":1,"confidence_rate":1},{"cnt":[[380,1298],[1775,1298],[1775,1343],[380,1343]],"region":{"top_left_x":380,"top_left_y":1297,"width":1395,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaedacc84d3b431b870850a10ae6b259","type":"text","conversion_output":true,"text":"protocol directed therapy and/or disease evaluations (and up to 1 week for surgery) for","text_display":" protocol directed therapy and/or disease evaluations (and up to 1 week for surgery) for","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[382,1341],[1775,1341],[1775,1386],[382,1386]],"region":{"top_left_x":382,"top_left_y":1340,"width":1393,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eccaa61d7a924eeda9bb5d1a1a7380c1","type":"text","conversion_output":true,"text":"valid clinical, patient and family logistical, or facility, procedure and/or anesthesia","text_display":" valid clinical, patient and family logistical, or facility, procedure and/or anesthesia","confidence":1,"confidence_rate":1},{"cnt":[[380,1386],[1775,1386],[1775,1431],[380,1431]],"region":{"top_left_x":380,"top_left_y":1385,"width":1395,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"089bb2263efc4409b02cb8e6de423f7a","type":"text","conversion_output":true,"text":"scheduling issues are acceptable per COG administrative Policy 5.14 (except where","text_display":" scheduling issues are acceptable per COG administrative Policy 5.14 (except where","confidence":1,"confidence_rate":1},{"cnt":[[382,1431],[1021,1431],[1021,1476],[382,1476]],"region":{"top_left_x":382,"top_left_y":1430,"width":639,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f11d71ce7dd461e8a3c200ae6a2835f","type":"text","conversion_output":true,"text":"explicitly prohibited within the protocol).","text_display":" explicitly prohibited within the protocol).","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[537,1568],[537,1611],[245,1611]],"region":{"top_left_x":244,"top_left_y":1568,"width":294,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2d295482bb241ad86e38f5e9fa2389a","type":"section_header","conversion_output":false,"children_ids":["18b4167d910147fab438dc9ba221037a"],"text":"","text_display":""},{"cnt":[[249,1573],[535,1573],[535,1609],[249,1609]],"region":{"top_left_x":249,"top_left_y":1572,"width":286,"height":38},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18b4167d910147fab438dc9ba221037a","type":"text","conversion_output":true,"parent_id":"b2d295482bb241ad86e38f5e9fa2389a","text":"16.1 CT Scans","text_display":"\n\n\\subsection*{16.1 CT Scans}","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1880,1611],[1880,1659],[245,1659]],"region":{"top_left_x":244,"top_left_y":1611,"width":1636,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e6d9225caff416eb81638f06053e3e1","type":"text","conversion_output":true,"text":"Axial imaging of the site of the primary tumor will be performed using low-dose technique according to","text_display":"\n\nAxial imaging of the site of the primary tumor will be performed using low-dose technique according to","confidence":1,"confidence_rate":1},{"cnt":[[245,1654],[1880,1654],[1880,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1654,"width":1636,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35959340edab4934afc6cea0836da128","type":"text","conversion_output":true,"text":"the ALARA concept. \\({ }^{129}\\) The studies will be performed using current-generation single or multi-detector","text_display":" the ALARA concept. \\({ }^{129}\\) The studies will be performed using current-generation single or multi-detector","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[1880,1702],[1880,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ee20092fc93467ea69c20a43310913a","type":"text","conversion_output":true,"text":"systems. CT slice thickness should be 5 mm or less. Imaging will be performed during the administration","text_display":" systems. CT slice thickness should be 5 mm or less. Imaging will be performed during the administration","confidence":1,"confidence_rate":1},{"cnt":[[245,1745],[1878,1745],[1878,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1744,"width":1634,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fddff676f5ab4dafbb47db5ecf75dea8","type":"text","conversion_output":true,"text":"of intravenous contrast, generally at \\(2 mL / kg\\). The use of oral contrast will be determined by the","text_display":" of intravenous contrast, generally at \\(2 mL / kg\\). 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Images will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1833],[1880,1833],[1880,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1832,"width":1636,"height":48},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7352d447b9a4dcd921b84536fba7ea4","type":"text","conversion_output":true,"text":"reconstructed in soft tissue and edge-enhanced bone/lung and liver algorithms. Coronal and sagittal","text_display":" reconstructed in soft tissue and edge-enhanced bone/lung and liver algorithms. Coronal and sagittal","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[917,1878],[917,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1877,"width":674,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fb4f46e8ec4458897d92b49a5e91f00","type":"text","conversion_output":true,"text":"multiplanar reconstructions may be helpful.","text_display":" multiplanar reconstructions may be helpful.","confidence":1,"confidence_rate":1},{"cnt":[[245,1966],[1878,1966],[1878,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1965,"width":1634,"height":49},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3634023411d148e2bc2f03184a85c2e6","type":"text","conversion_output":true,"text":"For all patients who achieve CR at end of induction therapy, pre-surgical and end of induction CT scans","text_display":"\n\nFor all patients who achieve CR at end of induction therapy, pre-surgical and end of induction CT scans","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1278,2011],[1278,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2010,"width":1035,"height":47},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb3923a0751a40e39b163bf6b9121459","type":"text","conversion_output":true,"text":"(or MRI if used instead of CT) will be submitted for central review","text_display":" (or MRI if used instead of CT) will be submitted for central review","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[561,2093],[561,2138],[245,2138]],"region":{"top_left_x":244,"top_left_y":2092,"width":317,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"572a034a2cd84483bf6eb8abb3a4ad38","type":"section_header","conversion_output":false,"children_ids":["5745cfb1e96247aababed5832570217f"],"text":"","text_display":""},{"cnt":[[249,2097],[559,2097],[559,2133],[249,2133]],"region":{"top_left_x":249,"top_left_y":2096,"width":310,"height":38},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5745cfb1e96247aababed5832570217f","type":"text","conversion_output":true,"parent_id":"572a034a2cd84483bf6eb8abb3a4ad38","text":"16.2 MRI Scans","text_display":"\n\n\\subsection*{16.2 MRI Scans}","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1880,2140],[1880,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2139,"width":1636,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bb761e7a9f14f90b756c2b13235d9e3","type":"text","conversion_output":true,"text":"Typically MRI will be performed on 1.5 T MRI units. Axial and at least one additional plane (coronal or","text_display":"\n\nTypically MRI will be performed on 1.5 T MRI units. Axial and at least one additional plane (coronal or","confidence":0.7563323974609375,"confidence_rate":0.9974871775700197},{"cnt":[[245,2185],[1878,2185],[1878,2230],[245,2230]],"region":{"top_left_x":244,"top_left_y":2184,"width":1634,"height":47},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb80192fbd734fdf9473d0791713d850","type":"text","conversion_output":true,"text":"sagittal) of the primary tumor will be performed using at least two pulse sequences (T1, T2, STIR,","text_display":" sagittal) of the primary tumor will be performed using at least two pulse sequences (T1, T2, STIR,","confidence":1,"confidence_rate":1},{"cnt":[[245,2228],[1878,2228],[1878,2275],[245,2275]],"region":{"top_left_x":244,"top_left_y":2227,"width":1634,"height":49},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"396b15b09aa34040b3bd081a8dd85769","type":"text","conversion_output":true,"text":"FLAIR, in/out phase, post contrast). 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preferred imaging modality in such cases (neck, chest, nonadrenal retroperitoneum) with spinal cord or","confidence":1,"confidence_rate":1},{"cnt":[[245,335],[1843,335],[1843,385],[245,385]],"region":{"top_left_x":244,"top_left_y":335,"width":1600,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7c2aec5dde94dcbb4e7149934a7bd2e","type":"text","conversion_output":true,"text":"canal encroachment. \\({ }^{130}\\) It may also be useful in evaluating an MIBG-avid focus detected in the skeleton","text_display":" canal encroachment. \\({ }^{130}\\) It may also be useful in evaluating an MIBG-avid focus detected in the skeleton","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[245,387],[471,387],[471,423],[245,423]],"region":{"top_left_x":244,"top_left_y":386,"width":227,"height":38},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79b07a3cbf784a86bdf5c8b54aad7b21","type":"text","conversion_output":true,"text":"or soft tissues.","text_display":" or soft tissues.","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1850,473],[1850,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1606,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19e7157273f64e3e9fe0d34000c7a9fb","type":"text","conversion_output":true,"text":"The lack of ionizing radiation also makes MRI attractive for younger children, but this must be balanced","text_display":"\n\nThe lack of ionizing radiation also makes MRI attractive for younger children, but this must be balanced","confidence":1,"confidence_rate":1},{"cnt":[[245,518],[1833,518],[1833,561],[245,561]],"region":{"top_left_x":244,"top_left_y":517,"width":1589,"height":44},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b549d9d8ef434330a10833b29beb59f5","type":"text","conversion_output":true,"text":"with the need for sedation in these patients. With the exceptions noted above, the choice of MRI or CT","text_display":" with the need for sedation in these patients. With the exceptions noted above, the choice of MRI or CT","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[982,559],[982,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":738,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a27fa04edd749a395f91f1b8359365d","type":"text","conversion_output":true,"text":"will be left to the referring pediatric radiologist.","text_display":" will be left to the referring pediatric radiologist.","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[730,649],[730,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":487,"height":51},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2813f74602f4ba4a05d9a93e97b4cb7","type":"section_header","conversion_output":false,"children_ids":["1e8699613134437a853db0bfc406f92c"],"text":"","text_display":""},{"cnt":[[249,653],[728,653],[728,696],[249,696]],"region":{"top_left_x":249,"top_left_y":653,"width":480,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e8699613134437a853db0bfc406f92c","type":"text","conversion_output":true,"parent_id":"b2813f74602f4ba4a05d9a93e97b4cb7","text":"16.3 Skeletal Scintigraphy","text_display":"\n\n\\subsection*{16.3 Skeletal Scintigraphy}","confidence":1,"confidence_rate":1},{"cnt":[[247,696],[1878,696],[1878,741],[247,741]],"region":{"top_left_x":247,"top_left_y":696,"width":1631,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"910b1d8caf67480eb072dfa9c978d4df","type":"text","conversion_output":true,"text":"Technetium 99 m methylene diphosphonate scans will include the entire skeleton, including multiple","text_display":"\n\nTechnetium 99 m methylene diphosphonate scans will include the entire skeleton, including multiple","confidence":0.63671875,"confidence_rate":0.9958288416617319},{"cnt":[[247,741],[1878,741],[1878,784],[247,784]],"region":{"top_left_x":247,"top_left_y":741,"width":1631,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4b93b271d3a416fbe9a493bb118f157","type":"text","conversion_output":true,"text":"overlapping spot images. Scans will be performed using a large field-of-view gamma camera with a high-","text_display":" overlapping spot images. Scans will be performed using a large field-of-view gamma camera with a high","confidence":1,"confidence_rate":1},{"cnt":[[245,784],[1878,784],[1878,827],[245,827]],"region":{"top_left_x":244,"top_left_y":784,"width":1634,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a8bb49c6c974fcb914c42c2e55a642c","type":"text","conversion_output":true,"text":"resolution collimator. The typical dose of Tc- 99 m MDP is \\(10.4 MBq / kg\\), with a minimum dose of 74","text_display":"resolution collimator. The typical dose of Tc- 99 m MDP is \\(10.4 MBq / kg\\), with a minimum dose of 74","confidence":0.9658987219445407,"confidence_rate":0.9996983386135266},{"cnt":[[245,821],[1878,821],[1878,872],[245,872]],"region":{"top_left_x":244,"top_left_y":820,"width":1634,"height":53},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5643f4b754114bb4b62f3a7eb30648e5","type":"text","conversion_output":true,"text":"MBq. \\({ }^{131}\\) In patients with stage 4 disease, if the diagnostic MIBG and bone scans are concordant for all","text_display":" MBq. \\({ }^{131}\\) In patients with stage 4 disease, if the diagnostic MIBG and bone scans are concordant for all","confidence":1,"confidence_rate":1},{"cnt":[[245,872],[1596,872],[1596,917],[245,917]],"region":{"top_left_x":244,"top_left_y":872,"width":1353,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21a0be0334b14ce388e2749f6c62ad67","type":"text","conversion_output":true,"text":"positive sites, then only MIBG scans, but not bone scans, will be required for follow up.","text_display":" positive sites, then only MIBG scans, but not bone scans, will be required for follow up.","confidence":1,"confidence_rate":1},{"cnt":[[245,956],[707,956],[707,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":956,"width":463,"height":52},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"582839709bf34217a193fe83cafcebbf","type":"section_header","conversion_output":false,"children_ids":["c22dc39cf7e347449a8317642db147c5"],"text":"","text_display":""},{"cnt":[[249,958],[703,958],[703,1003],[249,1003]],"region":{"top_left_x":249,"top_left_y":958,"width":454,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c22dc39cf7e347449a8317642db147c5","type":"text","conversion_output":true,"parent_id":"582839709bf34217a193fe83cafcebbf","text":"16.4 MIBG Scintigraphy","text_display":"\n\n\\subsection*{16.4 MIBG Scintigraphy}","confidence":1,"confidence_rate":1},{"cnt":[[249,997],[1876,997],[1876,1046],[249,1046]],"region":{"top_left_x":249,"top_left_y":996,"width":1627,"height":51},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84fcbdb8b6144f99891aa0af1c11835d","type":"text","conversion_output":true,"text":"\\({ }^{123}\\) I-MIBG studies of the entire body will be performed following pretreatment with supersaturated","text_display":"\n\\({ }^{123}\\) I-MIBG studies of the entire body will be performed following pretreatment with supersaturated","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1878,1044],[1878,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1044,"width":1634,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ebb097f72674e57b105ed3c9d42596f","type":"text","conversion_output":true,"text":"solution of potassium iodide (SSKI) (typical dose is 1 drop \\(/ 3\\) years of age one day prior and two days","text_display":" solution of potassium iodide (SSKI) (typical dose is 1 drop \\(/ 3\\) years of age one day prior and two days","confidence":0.9229624271392822,"confidence_rate":0.9992908113044775},{"cnt":[[245,1085],[1880,1085],[1880,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1084,"width":1636,"height":53},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db89728f318f4ed59547f2e13028695b","type":"text","conversion_output":true,"text":"following \\({ }^{123}\\) I-MIBG administration, with a maximum of 3 drops/day). This isotope has significantly less","text_display":" following \\({ }^{123}\\) I-MIBG administration, with a maximum of 3 drops/day). This isotope has significantly less","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1880,1130],[1880,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1130,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0eb04a32a4f741c68ba9bf34017825a7","type":"text","conversion_output":true,"text":"risk to the thyroid gland compared to \\({ }^{131} I\\)-MIBG. \\({ }^{132}\\) A typical dose of \\({ }^{123} I\\)-MIBG is \\(3.7 MBq / kg\\). Planar","text_display":" risk to the thyroid gland compared to \\({ }^{131} I\\)-MIBG. \\({ }^{132}\\) A typical dose of \\({ }^{123} I\\)-MIBG is \\(3.7 MBq / kg\\). Planar","confidence":0.7420757976360619,"confidence_rate":0.998064836614801},{"cnt":[[245,1177],[1876,1177],[1876,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1177,"width":1632,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26fbd09da7bb479781ca6a4be08bd0c2","type":"text","conversion_output":true,"text":"and, as appropriate, SPECT imaging will be performed. In patients with stage 4 disease, if the diagnostic","text_display":" and, as appropriate, SPECT imaging will be performed. 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If gonadal shielding does not interfere with","text_display":"\n\nThis will be performed as needed using ALARA technique. If gonadal shielding does not interfere with","confidence":1,"confidence_rate":1},{"cnt":[[245,1446],[1878,1446],[1878,1491],[245,1491]],"region":{"top_left_x":244,"top_left_y":1445,"width":1634,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58da9f21100345eaa45e66e46a0506f9","type":"text","conversion_output":true,"text":"diagnostic accuracy, it should be utilized. Breast shielding should also be utilized in scoliosis screening","text_display":" diagnostic accuracy, it should be utilized. Breast shielding should also be utilized in scoliosis screening","confidence":1,"confidence_rate":1},{"cnt":[[245,1491],[1880,1491],[1880,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1491,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fb59531de4440549a7d939efbc26c0e","type":"text","conversion_output":true,"text":"unless clinically there is a reason why it should be omitted. In patients with paraspinal disease on MRI at","text_display":" unless clinically there is a reason why it should be omitted. 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Diameter of a \"measurable","text_display":"\n\nTumors will be measured according to the COG radiology group guideline. Diameter of a \"measurable","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[1880,1753],[1880,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1753,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd58baec92cd43a08c8f4546de38400a","type":"text","conversion_output":true,"text":"mass\" must be at least twice the reconstructed slice thickness. Target lesions at baseline must be greater","text_display":" mass\" must be at least twice the reconstructed slice thickness. Target lesions at baseline must be greater","confidence":1,"confidence_rate":1},{"cnt":[[245,1798],[1878,1798],[1878,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1798,"width":1634,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c64998b963e4e08a711ca4e335bafde","type":"text","conversion_output":true,"text":"than 1 cm . When multiple or metastatic masses are present, all masses will be described, and up to 5","text_display":" than 1 cm . 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Alternatively,","text_display":"\n\nImages should preferably be submitted electronically using DICOM format to QARC. Alternatively,","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,516],[1882,516],[1882,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1639,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5deaa559d13c425e90636313735aecf5","type":"text","conversion_output":true,"text":"they may be submitted on CD using DICOM format. The third option would be hard copy submission of","text_display":" they may be submitted on CD using DICOM format. The third option would be hard copy submission of","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0300c0400093440283b231d416ac8054","type":"text","conversion_output":true,"text":"images including soft tissue (abdomen) windows as well as edge-enhanced lung, liver, and bone windows","text_display":" images including soft tissue (abdomen) windows as well as edge-enhanced lung, liver, and bone windows","confidence":1,"confidence_rate":1},{"cnt":[[245,604],[1880,604],[1880,649],[245,649]],"region":{"top_left_x":244,"top_left_y":603,"width":1636,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74e2a7daadb149b0b57084e8dfb5f101","type":"text","conversion_output":true,"text":"(for CT), or hard copy submission of all pulse sequences obtained (for MRI). Studies should not be","text_display":" (for CT), or hard copy submission of all pulse sequences obtained (for MRI). Studies should not be","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[917,649],[917,694],[245,694]],"region":{"top_left_x":244,"top_left_y":648,"width":674,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a72574e52697403abb3be9ce5970f405","type":"text","conversion_output":true,"text":"photographed smaller than 20 images/page.","text_display":" photographed smaller than 20 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(PTV2)","confidence":1,"confidence_rate":1},{"cnt":[[309,344],[1601,344],[1601,387],[309,387]],"region":{"top_left_x":309,"top_left_y":343,"width":1292,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebb044bd492f4bcdbc9839c6f63333a5","type":"text","conversion_output":true,"text":"- The PTV2 is a geometric concept and includes a margin surrounding the CTV2.","text_display":"\n- The PTV2 is a geometric concept and includes a margin surrounding the CTV2.","confidence":1,"confidence_rate":1},{"cnt":[[309,391],[1854,391],[1854,436],[309,436]],"region":{"top_left_x":309,"top_left_y":391,"width":1546,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f9e7cd62b734715bc61c5d028daa7bd","type":"text","conversion_output":true,"text":"- The PTV2 should account for physiologic change or motion in the CTV2 and set-up uncertainty.","text_display":"\n- The PTV2 should account for physiologic change or motion in 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does not have to be uniform in all dimensions; especially if it compromises","confidence":1,"confidence_rate":1},{"cnt":[[370,619],[1867,619],[1867,664],[370,664]],"region":{"top_left_x":369,"top_left_y":618,"width":1498,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"932f0e1f535547758807cb0fc59858cd","type":"text","conversion_output":true,"text":"normal tissue volumes or if directional target or normal tissue motion is assessed and understood.","text_display":" normal tissue volumes or if directional target or normal tissue motion is assessed and understood.","confidence":1,"confidence_rate":1},{"cnt":[[245,707],[1545,707],[1545,750],[245,750]],"region":{"top_left_x":244,"top_left_y":706,"width":1301,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38c73db908024f9881076503659643a1","type":"text","conversion_output":true,"text":"Motion Management and Margins to Account for Target Volume and Organ Motion","text_display":"\n\nMotion Management and Margins to Account for Target Volume and Organ Motion","confidence":1,"confidence_rate":1},{"cnt":[[247,752],[1876,752],[1876,795],[247,795]],"region":{"top_left_x":247,"top_left_y":751,"width":1629,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a280819947a14726a95d07b8dcba2ede","type":"text","conversion_output":true,"text":"Considering motion of normal tissues and target volumes is important. The internal target volume (ITV)","text_display":"\nConsidering motion of normal tissues and target volumes is important. The internal target volume (ITV)","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[1878,795],[1878,838],[245,838]],"region":{"top_left_x":244,"top_left_y":794,"width":1634,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c215af77caf44999105290e75131f53","type":"text","conversion_output":true,"text":"is defined as the CTV surrounded by the IM component of the PTV and is meant to account for potential","text_display":" is defined as the CTV surrounded by the IM component of the PTV and is meant to account for potential","confidence":1,"confidence_rate":1},{"cnt":[[245,838],[1878,838],[1878,883],[245,883]],"region":{"top_left_x":244,"top_left_y":837,"width":1634,"height":47},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8674f06576bb4e069c84bfd084ad2799","type":"text","conversion_output":true,"text":"motion of the CTV. The planning organ at risk volume (PRV) includes the OR surrounded by a margin to","text_display":" motion of the CTV. The planning organ at risk volume (PRV) includes the OR surrounded by a margin to","confidence":1,"confidence_rate":1},{"cnt":[[245,881],[1880,881],[1880,926],[245,926]],"region":{"top_left_x":244,"top_left_y":880,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ad2eacc1c98433292fab006c7124a0b","type":"text","conversion_output":true,"text":"compensate for physiologic change in the target volume. If adequate clinical data do not exist to define","text_display":" compensate for physiologic change in the target volume. If adequate clinical data do not exist to define","confidence":1,"confidence_rate":1},{"cnt":[[245,924],[1635,924],[1635,969],[245,969]],"region":{"top_left_x":244,"top_left_y":923,"width":1391,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f955ba8d0e854e5cb0079c382db8af8e","type":"text","conversion_output":true,"text":"the IM component of the PTV or the PRV margin, the following suggestions are provided:","text_display":" the IM component of the PTV or the PRV margin, the following suggestions are provided:","confidence":1,"confidence_rate":1},{"cnt":[[309,1016],[1489,1016],[1489,1059],[309,1059]],"region":{"top_left_x":309,"top_left_y":1016,"width":1180,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce30078021f64509b8026b9015513be0","type":"text","conversion_output":true,"text":"- A margin of at least 0.5 cm should be added to any OR to form the PRV.","text_display":"\n- A margin of at least 0.5 cm should be added to any OR to form the PRV.","confidence":0.9975600242614746,"confidence_rate":0.9999702082812172},{"cnt":[[309,1061],[1880,1061],[1880,1106],[309,1106]],"region":{"top_left_x":309,"top_left_y":1061,"width":1571,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fabef6a0da8418c9fe81dbd43647f07","type":"text","conversion_output":true,"text":"- For a CTV susceptible to physiologic motion, a margin of at least 0.5 cm should be added to the","text_display":"\n- For a CTV susceptible to physiologic motion, a margin of at least 0.5 cm should be added to the","confidence":1,"confidence_rate":1},{"cnt":[[370,1106],[1644,1106],[1644,1154],[370,1154]],"region":{"top_left_x":369,"top_left_y":1106,"width":1275,"height":48},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e8a9929169d4d16b33db9e0c7059b99","type":"text","conversion_output":true,"text":"CTV prior to PTV margin expansion or a PTV margin of 1.0 cm should be chosen.","text_display":" CTV prior to PTV margin expansion or a PTV margin of 1.0 cm should be chosen.","confidence":1,"confidence_rate":1},{"cnt":[[309,1154],[1884,1154],[1884,1197],[309,1197]],"region":{"top_left_x":309,"top_left_y":1153,"width":1576,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf4af2b181124582b9cf1029d8a22f41","type":"text","conversion_output":true,"text":"- For tumors of the thorax or abdomen, an assessment should be made to determine the extent of","text_display":"\n- For tumors of the thorax or abdomen, an assessment should be made to determine the extent of","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[370,1199],[1502,1199],[1502,1244],[370,1244]],"region":{"top_left_x":369,"top_left_y":1198,"width":1133,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14a7c18bd0ce40768d4502c43490703c","type":"text","conversion_output":true,"text":"motion present. PTV margins should include this motion as a component.","text_display":" motion present. 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If required to achieve this goal, techniques for managing or","text_display":" be limited to 0.5 cm in any direction. 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Wedges, compensators, and other methods of generating more uniform dose","confidence":1,"confidence_rate":1},{"cnt":[[245,1989],[694,1989],[694,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1989,"width":450,"height":46},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"812db59453384686ba7fb7676f744fde","type":"text","conversion_output":true,"text":"distributions are encouraged.","text_display":" distributions are encouraged.","confidence":1,"confidence_rate":1},{"cnt":[[245,2071],[1880,2071],[1880,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2071,"width":1636,"height":46},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10d759e1ac7a4779bc4a32708a7b6ef0","type":"text","conversion_output":true,"text":"Interruptions, Delays and Dose Modifications: There will be no planned rests or breaks from treatment,","text_display":"\n\nInterruptions, Delays and Dose Modifications: There will be no planned rests or breaks from treatment,","confidence":1,"confidence_rate":1},{"cnt":[[245,2114],[1880,2114],[1880,2161],[245,2161]],"region":{"top_left_x":244,"top_left_y":2114,"width":1636,"height":48},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48443d286cd441b2a808725db2fa52bd","type":"text","conversion_output":true,"text":"and once radiation therapy has been initiated, treatment will not be interrupted except for any life","text_display":" and once radiation therapy has been initiated, treatment will not be interrupted except for any life","confidence":1,"confidence_rate":1},{"cnt":[[245,2161],[1880,2161],[1880,2209],[245,2209]],"region":{"top_left_x":244,"top_left_y":2161,"width":1636,"height":48},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e172926941df47ce83f68ac0a119c9dc","type":"text","conversion_output":true,"text":"threatening infection or severe hematologic toxicity defined as \\(ANC <300 / \\mu L\\) or platelets less than","text_display":" threatening infection or severe hematologic toxicity defined as \\(ANC <300 / \\mu L\\) or platelets less than","confidence":0.97607421875,"confidence_rate":0.9997818557639507},{"cnt":[[245,2209],[1880,2209],[1880,2256],[245,2256]],"region":{"top_left_x":244,"top_left_y":2208,"width":1636,"height":48},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc1a1249b3d4424dbe497153bbfbed4b","type":"text","conversion_output":true,"text":"\\(40,000 / \\mu L\\) during the course of treatment. Under these circumstances, radiation therapy shall be delayed","text_display":" \\(40,000 / \\mu L\\) during the course of treatment. Under these circumstances, radiation therapy shall be delayed","confidence":1,"confidence_rate":1},{"cnt":[[245,2254],[1880,2254],[1880,2299],[245,2299]],"region":{"top_left_x":244,"top_left_y":2253,"width":1636,"height":46},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf4e3a6f541e42c3aedb90ec23b09cf4","type":"text","conversion_output":true,"text":"until the counts have recovered. Blood product support should be instituted according to","text_display":" until the counts have recovered. 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There should be no","confidence":1,"confidence_rate":1},{"cnt":[[245,2385],[1880,2385],[1880,2432],[245,2432]],"region":{"top_left_x":244,"top_left_y":2384,"width":1636,"height":49},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20d11856bfab47b3af0519126364b9f8","type":"text","conversion_output":true,"text":"modifications in dose fractionation due to age or field size. If any area has been previously treated","text_display":" modifications in dose fractionation due to age or field size. 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Although simple opposed field plans are acceptable, the use","text_display":" compromising coverage of the target volume. Although simple opposed field plans are acceptable, the use","confidence":1,"confidence_rate":1},{"cnt":[[245,432],[1880,432],[1880,477],[245,477]],"region":{"top_left_x":244,"top_left_y":431,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f02deb99702e45af880d8aade4da1a3c","type":"text","conversion_output":true,"text":"of oblique fields, or 3-dimensional conformal therapy (coplanar or non-coplanar), or IMRT is encouraged","text_display":" of oblique fields, or 3-dimensional conformal therapy (coplanar or non-coplanar), or IMRT is encouraged","confidence":1,"confidence_rate":1},{"cnt":[[245,477],[1033,477],[1033,522],[245,522]],"region":{"top_left_x":244,"top_left_y":476,"width":790,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"249f3763ad5b4dc8a9fbba7058e4b408","type":"text","conversion_output":true,"text":"to minimize dose to normal surrounding structures.","text_display":" to minimize dose to normal surrounding structures.","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d696c19c00004e8cb4d54c5fa2336b18","type":"text","conversion_output":true,"text":"Patient Position: Reproducible setups are critical and the use of immobilization devices is strongly","text_display":"\n\nPatient Position: Reproducible setups are critical and the use of immobilization devices is strongly","confidence":1,"confidence_rate":1},{"cnt":[[245,608],[1450,608],[1450,655],[245,655]],"region":{"top_left_x":244,"top_left_y":608,"width":1207,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ba975465f934ecdb72f89307f0eb546","type":"text","conversion_output":true,"text":"encouraged. Use of anesthesia is permitted if necessary for proper positioning.","text_display":" encouraged. Use of anesthesia is permitted if necessary for proper positioning.","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1884,692],[1884,741],[245,741]],"region":{"top_left_x":244,"top_left_y":691,"width":1641,"height":51},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c46816384dd4ba0ad86b4035a7fbe67","type":"text","conversion_output":true,"text":"Field Shaping: Field shaping shall be done with either customized cerrobend blocking or multileaf","text_display":"\n\nField Shaping: Field shaping shall be done with either customized cerrobend blocking or multileaf","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,739],[436,739],[436,780],[245,780]],"region":{"top_left_x":244,"top_left_y":739,"width":193,"height":41},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15da3d87276645c896d8eaa608bc30ce","type":"text","conversion_output":true,"text":"collimation.","text_display":" collimation.","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[629,825],[629,879],[245,879]],"region":{"top_left_x":244,"top_left_y":825,"width":386,"height":54},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9fd91b71fad48bf990a6810a2e065c3","type":"section_header","conversion_output":false,"children_ids":["26770fd752be4923950d9c6863102411"],"text":"","text_display":""},{"cnt":[[249,829],[625,829],[625,874],[249,874]],"region":{"top_left_x":249,"top_left_y":829,"width":377,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26770fd752be4923950d9c6863102411","type":"text","conversion_output":true,"parent_id":"b9fd91b71fad48bf990a6810a2e065c3","text":"17.7 Organs at Risk","text_display":"\n\n\\subsection*{17.7 Organs at Risk}","confidence":1,"confidence_rate":1},{"cnt":[[245,915],[1880,915],[1880,965],[245,965]],"region":{"top_left_x":244,"top_left_y":915,"width":1636,"height":50},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4dd16fe3edd4ce181ec3638e6725d93","type":"text","conversion_output":true,"text":"The organ at risk guidelines in this section are recommendations. If the recommended doses to the organs","text_display":"\n\nThe organ at risk guidelines in this section are recommendations. If the recommended doses to the organs","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[1880,958],[1880,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":958,"width":1636,"height":50},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fdb0fa3eba634188b128386d60d1b7a5","type":"text","conversion_output":true,"text":"at risk are exceeded because of target volume coverage requirements or other conditions (See","text_display":" at risk are exceeded because of target volume coverage requirements or other conditions (See","confidence":1,"confidence_rate":1},{"cnt":[[245,1005],[1880,1005],[1880,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1005,"width":1636,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"656efd3bf73b45698d24c5d92fd926bd","type":"text","conversion_output":true,"text":"Section 17.1.2), an explanation should be included in the quality assurance documentation. In some cases,","text_display":" Section 17.1.2), an explanation should be included in the quality assurance documentation. In some cases,","confidence":1,"confidence_rate":1},{"cnt":[[245,1048],[1880,1048],[1880,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1048,"width":1636,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8ebbcbfe28f49eb9dda26a185899b83","type":"text","conversion_output":true,"text":"IMRT may be the preferred treatment method to meet these recommendations and the required target","text_display":" IMRT may be the preferred treatment method to meet these recommendations and the required target","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[690,1091],[690,1139],[245,1139]],"region":{"top_left_x":244,"top_left_y":1091,"width":446,"height":48},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76ff27c5f60543aabc7ec1a2f1ba8714","type":"text","conversion_output":true,"text":"volume coverage guidelines.","text_display":" volume coverage guidelines.","confidence":1,"confidence_rate":1},{"cnt":[[245,1188],[1880,1188],[1880,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1188,"width":1636,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b220974449cd4e48a85505026b15903b","type":"text","conversion_output":true,"text":"Peritoneal Cavity: When the entire peritoneal cavity must be irradiated, the volume to be treated extends","text_display":"\n\nPeritoneal Cavity: When the entire peritoneal cavity must be irradiated, the volume to be treated extends","confidence":1,"confidence_rate":1},{"cnt":[[245,1233],[1882,1233],[1882,1278],[245,1278]],"region":{"top_left_x":244,"top_left_y":1233,"width":1639,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bcf60457ec34e2985768b65338e16eb","type":"text","conversion_output":true,"text":"from the diaphragmatic domes to the level of the bottom of the obturator foramina. The principles of","text_display":" from the diaphragmatic domes to the level of the bottom of the obturator foramina. The principles of","confidence":1,"confidence_rate":1},{"cnt":[[245,1276],[1880,1276],[1880,1321],[245,1321]],"region":{"top_left_x":244,"top_left_y":1276,"width":1636,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a0a255c69644b20a4a0101449ebf4fb","type":"text","conversion_output":true,"text":"tailoring fields by site should be considered (Table 17.1.2) and the recommendations for organs at risk","text_display":" tailoring fields by site should be considered (Table 17.1.2) and the recommendations for organs at risk","confidence":1,"confidence_rate":1},{"cnt":[[245,1319],[556,1319],[556,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1319,"width":313,"height":41},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3003c2b21d6b40d4bc9bceb40e711011","type":"text","conversion_output":true,"text":"should be followed.","text_display":" should be followed.","confidence":1,"confidence_rate":1},{"cnt":[[245,1405],[1880,1405],[1880,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff1f8f8ede154807bc240bc8884e461c","type":"text","conversion_output":true,"text":"Liver: The liver dose should be minimized to reduce the risk of sinusoidal-obstruction syndrome","text_display":"\n\nLiver: The liver dose should be minimized to reduce the risk of sinusoidal-obstruction syndrome","confidence":1,"confidence_rate":1},{"cnt":[[245,1452],[1880,1452],[1880,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1452,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3661adb5c61a434a983eb779295e3720","type":"text","conversion_output":true,"text":"(SOS), formerly known as veno-occlusive disease. No more than \\(50 \\%\\) of the liver shall receive a","text_display":" (SOS), formerly known as veno-occlusive disease. No more than \\(50 \\%\\) of the liver shall receive a","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,1495],[1880,1495],[1880,1540],[245,1540]],"region":{"top_left_x":244,"top_left_y":1495,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5b44aeaad5d41cda30bc0975c8bd444","type":"text","conversion_output":true,"text":"cumulative dose greater than 900 cGy and no more than \\(25 \\%\\) of the liver shall receive a dose greater than","text_display":" cumulative dose greater than 900 cGy and no more than \\(25 \\%\\) of the liver shall receive a dose greater than","confidence":0.9776878296397626,"confidence_rate":0.9998038031404477},{"cnt":[[245,1538],[410,1538],[410,1586],[245,1586]],"region":{"top_left_x":244,"top_left_y":1538,"width":167,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96b6a78e7fb940ba9ef6a1eaab054f0b","type":"text","conversion_output":true,"text":"1800 cGy.","text_display":" 1800 cGy.","confidence":0.9990234375,"confidence_rate":0.9999248459282221},{"cnt":[[245,1626],[1635,1626],[1635,1674],[245,1674]],"region":{"top_left_x":244,"top_left_y":1626,"width":1391,"height":48},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49bde0ab13514716b0093dc86cce19fe","type":"text","conversion_output":true,"text":"Kidney: The kidney doses should be minimized to reduce the risk of chronic renal failure.","text_display":"\n\nKidney: The kidney doses should be minimized to reduce the risk of chronic renal failure.","confidence":1,"confidence_rate":1},{"cnt":[[245,1714],[1880,1714],[1880,1762],[245,1762]],"region":{"top_left_x":244,"top_left_y":1714,"width":1636,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca7a5186ea1e41b1982a0ce86547d9ef","type":"text","conversion_output":true,"text":"If the primary tumor demonstrates laterality to the right or left side, an ipsilateral and contralateral kidney","text_display":"\nIf the primary tumor demonstrates laterality to the right or left side, an ipsilateral and contralateral kidney","confidence":1,"confidence_rate":1},{"cnt":[[245,1757],[1884,1757],[1884,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1757,"width":1641,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"743ef1d5f84644aea3e345ef9f3bf6ca","type":"text","conversion_output":true,"text":"should be designated. 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Treatment Area & Required DVH \\\\\n\\hline Neck & Thyroid \\\\\n\\hline Chest & Right Lung \\\\\n\\hline & Left Lung \\\\\n\\hline & Heart \\\\\n\\hline Abdomen & Liver \\\\\n\\hline & Right Kidney \\\\\n\\hline & Left Kidney \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 17.8 Required normal tissue DVH data according to primary treatment site}\n\\begin{tabular}{|l|l|}\n\\hline Treatment Area & Required DVH \\\\\n\\hline Neck & Thyroid \\\\\n\\hline Chest & Right Lung \\\\\n\\hline & Left Lung \\\\\n\\hline & Heart \\\\\n\\hline Abdomen & Liver \\\\\n\\hline & Right Kidney \\\\\n\\hline & Left Kidney 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Patients","text_display":"\n\nInstitutional standard operating procedures (SOPs) will be used for mobilization and pheresis. Patients","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d83e74b064bf4acebf98cdf76ef7b643","type":"text","conversion_output":true,"text":"should begin G-CSF starting one day after completing a cycle of chemotherapy. They should continue on","text_display":" should begin G-CSF starting one day after completing a cycle of chemotherapy. They should continue on","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1880,382],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1636,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04fe9fc77de7471a96588dd989296e50","type":"text","conversion_output":true,"text":"G-CSF \\(5 mcg / kg /\\) day while recovering from the cycle of chemotherapy until the post-nadir ANC > 500-","text_display":" G-CSF \\(5 mcg / kg /\\) day while recovering from the cycle of chemotherapy until the post-nadir ANC > 500","confidence":0.958574028336443,"confidence_rate":0.9996223170013392},{"cnt":[[247,430],[1880,430],[1880,477],[247,477]],"region":{"top_left_x":247,"top_left_y":429,"width":1633,"height":48},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3005f27424249599ecb0ab0e6531676","type":"text","conversion_output":true,"text":"\\(1000 / \\mu L\\), at which point it is recommended to increase the dose of G-CSF to at least \\(10 mcg / kg /\\) day per","text_display":"\\(1000 / \\mu L\\), at which point it is recommended to increase the dose of G-CSF to at least \\(10 mcg / kg /\\) day per","confidence":0.995610237121582,"confidence_rate":0.9999627174223212},{"cnt":[[245,475],[574,475],[574,522],[245,522]],"region":{"top_left_x":244,"top_left_y":474,"width":330,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6fb0dfefc59410e9a6fdee3ed1e24b6","type":"text","conversion_output":true,"text":"institutional policies.","text_display":" institutional policies.","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1880,563],[1880,608],[245,608]],"region":{"top_left_x":244,"top_left_y":562,"width":1636,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55e4547797d84214be9fdb2c41231591","type":"text","conversion_output":true,"text":"Institutions which time collections using circulating CD34 cell counts will generally begin when the","text_display":"\n\nInstitutions which time collections using circulating CD34 cell counts will generally begin when the","confidence":1,"confidence_rate":1},{"cnt":[[245,608],[1880,608],[1880,655],[245,655]],"region":{"top_left_x":244,"top_left_y":608,"width":1636,"height":48},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4dc6f6eddfe54208a24ed6cd75d12f0d","type":"text","conversion_output":true,"text":"count is \\(\\geq 10-20\\) cells \\(/ \\mu L\\). 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Such patients should be off their G-CSF for 5-7 days before restarting it","text_display":" PBSC collections are completed. Such patients should be off their G-CSF for 5-7 days before restarting it","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,1048],[1543,1048],[1543,1096],[245,1096]],"region":{"top_left_x":244,"top_left_y":1048,"width":1299,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54b9b19bb7524d53975ee75a0b55930c","type":"text","conversion_output":true,"text":"for mobilization. If the WBC is \\(>60,000\\), decrease G-CSF dose to 5 micrograms \\(/ kg\\).","text_display":" for mobilization. If the WBC is \\(>60,000\\), decrease G-CSF dose to 5 micrograms \\(/ kg\\).","confidence":0.9248411655426025,"confidence_rate":0.999218972469495},{"cnt":[[245,1177],[655,1177],[655,1225],[245,1225]],"region":{"top_left_x":244,"top_left_y":1177,"width":412,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db6d90e1867a4307bef3f476b4764836","type":"section_header","conversion_output":false,"children_ids":["b275054e22c04373a97780fe7b74a713"],"text":"","text_display":""},{"cnt":[[249,1182],[651,1182],[651,1218],[249,1218]],"region":{"top_left_x":249,"top_left_y":1181,"width":402,"height":38},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b275054e22c04373a97780fe7b74a713","type":"text","conversion_output":true,"parent_id":"db6d90e1867a4307bef3f476b4764836","text":"19.3 PBSC Collection","text_display":"\n\n\\subsection*{19.3 PBSC Collection}","confidence":1,"confidence_rate":1},{"cnt":[[245,1263],[672,1263],[672,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1263,"width":429,"height":54},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a7820bea8114bdbaef517431bf07df0","type":"section_header","conversion_output":false,"children_ids":["b2ca8eb9853e40e78909fb3368a7f59a"],"text":"","text_display":""},{"cnt":[[249,1268],[672,1268],[672,1313],[249,1313]],"region":{"top_left_x":249,"top_left_y":1267,"width":424,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2ca8eb9853e40e78909fb3368a7f59a","type":"text","conversion_output":true,"parent_id":"8a7820bea8114bdbaef517431bf07df0","text":"19.3.1 Laboratory Studies","text_display":"\n\n\\subsection*{19.3.1 Laboratory Studies}","confidence":1,"confidence_rate":1},{"cnt":[[245,1311],[1863,1311],[1863,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1310,"width":1619,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03b8572de96143fe82f0af8ac596ed4a","type":"text","conversion_output":true,"text":"For patients \\(<25 kg\\), a type and cross for PRBC should be performed one day prior to procedure to avoid","text_display":"\n\nFor patients \\(<25 kg\\), a type and cross for PRBC should be performed one day prior to procedure to avoid","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[245,1354],[509,1354],[509,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1353,"width":266,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9d8f0bdc9ca429fa08d7baed53c9fb7","type":"text","conversion_output":true,"text":"apheresis delays.","text_display":" apheresis delays.","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[679,1439],[679,1491],[245,1491]],"region":{"top_left_x":244,"top_left_y":1439,"width":435,"height":53},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"317bff82e0cb4e4983b217b275354893","type":"section_header","conversion_output":false,"children_ids":["3d4a112c07a24f76b7ec701706bcfead"],"text":"","text_display":""},{"cnt":[[249,1444],[677,1444],[677,1489],[249,1489]],"region":{"top_left_x":249,"top_left_y":1443,"width":428,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d4a112c07a24f76b7ec701706bcfead","type":"text","conversion_output":true,"parent_id":"317bff82e0cb4e4983b217b275354893","text":"19.3.2 Apheresis Machine","text_display":"\n\n\\subsection*{19.3.2 Apheresis Machine}","confidence":1,"confidence_rate":1},{"cnt":[[247,1487],[1841,1487],[1841,1532],[247,1532]],"region":{"top_left_x":247,"top_left_y":1486,"width":1595,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1e3326f683448408c29b5185427974a","type":"text","conversion_output":true,"text":"The Cobe Spectra or the Fenwal CS 3000+ is recommended because the continuous flow centrifugation","text_display":"\n\nThe Cobe Spectra or the Fenwal CS 3000+ is recommended because the continuous flow centrifugation","confidence":0.93603515625,"confidence_rate":0.9993521487393113},{"cnt":[[245,1530],[1695,1530],[1695,1575],[245,1575]],"region":{"top_left_x":244,"top_left_y":1529,"width":1452,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6ce5ebda6584c28abf528e196819513","type":"text","conversion_output":true,"text":"devices are better tolerated than discontinuous flow machines. Institutional SOPs will be used.","text_display":" devices are better tolerated than discontinuous flow machines. 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During","text_display":"\n\nIt is recommended that large volume apheresis be performed on all patients for each collection. During","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1850,1886],[1850,1934],[245,1934]],"region":{"top_left_x":244,"top_left_y":1886,"width":1606,"height":48},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cac388469f2b4daea67cea7a283939d1","type":"text","conversion_output":true,"text":"each leukopheresis procedure, the typical target volume of whole blood processed will be approximately","text_display":" each leukopheresis procedure, the typical target volume of whole blood processed will be approximately","confidence":1,"confidence_rate":1},{"cnt":[[245,1929],[720,1929],[720,1979],[245,1979]],"region":{"top_left_x":244,"top_left_y":1929,"width":476,"height":50},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dda8ad581d1d44a5baf6e98102c51bd2","type":"text","conversion_output":true,"text":"\\(480 mL / kg\\) (6 blood volumes).","text_display":" \\(480 mL / kg\\) (6 blood volumes).","confidence":1,"confidence_rate":1},{"cnt":[[245,2020],[1807,2020],[1807,2075],[245,2075]],"region":{"top_left_x":244,"top_left_y":2019,"width":1563,"height":57},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d31d75fd73ad4e3c849f8f66b05188d4","type":"text","conversion_output":true,"text":"Optimal collection goal (total for all collections) is \\(10 \\times 10^{6}\\) CD \\(34+\\) cells \\(/ kg\\) for PBSC. The targeted","text_display":"\n\nOptimal collection goal (total for all collections) is \\(10 \\times 10^{6}\\) CD \\(34+\\) cells \\(/ kg\\) for PBSC. The targeted","confidence":0.8471878829877824,"confidence_rate":0.998674217329637},{"cnt":[[245,2073],[1833,2073],[1833,2121],[245,2121]],"region":{"top_left_x":244,"top_left_y":2073,"width":1589,"height":48},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c31652ac7afa42fba9d08dbc43effc7d","type":"text","conversion_output":true,"text":"number of cells can usually be obtained in 1-3 collection days. It is recommended that the collection be","text_display":" number of cells can usually be obtained in 1-3 collection days. It is recommended that the collection be","confidence":0.98828125,"confidence_rate":0.999891859464563},{"cnt":[[245,2118],[793,2118],[793,2163],[245,2163]],"region":{"top_left_x":244,"top_left_y":2118,"width":549,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91443570142a4ee8a2b0abffaffed918","type":"text","conversion_output":true,"text":"stored in at least 3 aliquots of cells:","text_display":" stored in at least 3 aliquots of cells:","confidence":1,"confidence_rate":1},{"cnt":[[309,2161],[1201,2161],[1201,2211],[309,2211]],"region":{"top_left_x":309,"top_left_y":2161,"width":892,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84b043ba76e04d258c940a4ff982dede","type":"text","conversion_output":true,"text":"- \\(2-4 \\times 10^{6}\\) CD34+ cells/kg for the first HSCT procedure","text_display":"\n- \\(2-4 \\times 10^{6}\\) CD34+ cells/kg for the first HSCT 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use.","text_display":"\n- \\(2-3 \\times 10^{6} CD 34+\\) cells/kg as a backup for delayed engraftment, or for potential subsequent use.","confidence":0.5556579487281397,"confidence_rate":0.9947202719350595},{"cnt":[[370,2299],[1762,2299],[1762,2348],[370,2348]],"region":{"top_left_x":369,"top_left_y":2298,"width":1393,"height":51},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cdfb39df59b4c9f85be0ba454491e22","type":"text","conversion_output":true,"text":"Because of the advantages of collecting these backup cells during this pheresis episode (as","text_display":" Because of the advantages of collecting these backup cells during this pheresis episode (as","confidence":1,"confidence_rate":1},{"cnt":[[370,2342],[1841,2342],[1841,2391],[370,2391]],"region":{"top_left_x":369,"top_left_y":2341,"width":1473,"height":51},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2040aa592d4c413b8c45bdf96e83c6dc","type":"text","conversion_output":true,"text":"opposed to later in the patient's clinical course), \\({ }^{133}\\) it is highly recommended that these cells be","text_display":" opposed to later in the patient's clinical course), \\({ }^{133}\\) it is highly recommended that these cells be","confidence":1,"confidence_rate":1},{"cnt":[[370,2389],[1313,2389],[1313,2436],[370,2436]],"region":{"top_left_x":369,"top_left_y":2389,"width":944,"height":48},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30bb7c6e70494b41a6c7c2cff4b2c2e3","type":"text","conversion_output":true,"text":"collected, even if this requires an additional day of apheresis.","text_display":" collected, even 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However, should the patient's medical condition prohibit use of apheresis, it is appropriate to","confidence":1,"confidence_rate":1},{"cnt":[[247,825],[1369,825],[1369,868],[247,868]],"region":{"top_left_x":247,"top_left_y":825,"width":1122,"height":43},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cde71a2e75154fb3818df7538b7ec7eb","type":"text","conversion_output":true,"text":"delay PBSC mobilization and harvest after subsequent induction therapy.","text_display":" delay PBSC mobilization and harvest after subsequent induction therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1880,868],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1636,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dc3d9a0f2f94d079ff5d4721ae967b5","type":"text","conversion_output":true,"text":"PBSC IMMUNOCYTOLOGY IS NOT REQUIRED FOR STUDY PARTICIPATION OR CELL","text_display":"\nPBSC IMMUNOCYTOLOGY IS NOT REQUIRED FOR STUDY PARTICIPATION OR CELL","confidence":1,"confidence_rate":1},{"cnt":[[245,913],[1880,913],[1880,956],[245,956]],"region":{"top_left_x":244,"top_left_y":913,"width":1636,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb815d0b83ff44c6b61ce4115dba0067","type":"text","conversion_output":true,"text":"INFUSION. 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Investigator discretion should be used, and individual considerations made for","text_display":" provided in this appendix. 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G-CSF should be continued until harvest is completed. See guidelines for G-CSF dosing","text_display":" factor support. G-CSF should be continued until harvest is completed. 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Study & Stage & Age & MYCN & Ploidy & Histology & Other \\\\\n\\hline ANBL00B1 & 1 & any & any & any & any & \\\\\n\\hline & & & & & & \\\\\n\\hline ANBL00B1 & 2a/2b & any & not amp & any & any & resection \\(\\geq 50 \\%\\) \\\\\n\\hline ANBL0531 & 2a/2b & any & not amp & any & any & resection <50\\% \\\\\n\\hline ANBL0531 & 2a/2b & any & not amp & any & any & biopsy only \\\\\n\\hline ANBL0532 & 2a/2b & any & amp & any & any & any degree of resection \\\\\n\\hline & & & & & & \\\\\n\\hline ANBL0531 & 3 & <547d & not amp & any & any & \\\\\n\\hline ANBL0531 & 3 & \\(\\geq 547 d\\) & not amp & any & FH & \\\\\n\\hline ANBL0532 & 3 & any & amp & any & any & \\\\\n\\hline ANBL0532 & 3 & \\(\\geq 547 d\\) & not amp & any & UH & \\\\\n\\hline & & & & & & \\\\\n\\hline ANBL0532 & 4 & <365d & amp & any & any & \\\\\n\\hline ANBL0531 & 4 & <365d & not amp & any & any & \\\\\n\\hline ANBL0532 & 4 & 365-<547d & amp & any & any & \\\\\n\\hline ANBL0532 & 4 & 365-<547d & any & \\(D I = 1\\) & any & \\\\\n\\hline ANBL0532 & 4 & 365-<547d & any & any & UH & \\\\\n\\hline ANBL0531 & 4 & \\(365-<547 d\\) & not amp & DI \\(>1\\) & FH & \\\\\n\\hline ANBL0532 & 4 & \\(\\geq 547 d\\) & any & any & any & \\\\\n\\hline & & & & & & \\\\\n\\hline ANBL00B1 & 4s & <365d & not amp & DI \\(>1\\) & FH & asymptomatic \\\\\n\\hline ANBL0531 & 4s & <365d & not amp & \\(DI =1\\) & any & asymp or symp \\\\\n\\hline ANBL0531 & 4s & <365d & missing & missing & missing & too sick for biopsy \\\\\n\\hline ANBL0531 & 4s & <365d & not amp & any & any & symptomatic \\\\\n\\hline ANBL0531 & 4s & <365d & not amp & any & UH & asymp or symp \\\\\n\\hline ANBL0532 & 4s & <365d & amp & any & any & asymp or symp \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|l|}\n\\hline Study & Stage & Age & MYCN & Ploidy & Histology & Other \\\\\n\\hline ANBL00B1 & 1 & any & any & any & any & \\\\\n\\hline & & & & & & \\\\\n\\hline ANBL00B1 & 2a/2b & any & not amp & any & any & resection \\(\\geq 50 \\%\\) \\\\\n\\hline ANBL0531 & 2a/2b & any & not amp & any & any & resection <50\\% \\\\\n\\hline ANBL0531 & 2a/2b & any & not amp & any & any & biopsy only \\\\\n\\hline ANBL0532 & 2a/2b & any & amp & any & any & any degree of resection \\\\\n\\hline & & & & & & \\\\\n\\hline ANBL0531 & 3 & <547d & not amp & any & any & \\\\\n\\hline ANBL0531 & 3 & \\(\\geq 547 d\\) & not amp & any & FH & \\\\\n\\hline ANBL0532 & 3 & any & amp & any & any & \\\\\n\\hline ANBL0532 & 3 & \\(\\geq 547 d\\) & not amp & any & UH & \\\\\n\\hline & & & & & & \\\\\n\\hline ANBL0532 & 4 & <365d & amp & any & any & \\\\\n\\hline ANBL0531 & 4 & <365d & not amp & any & any & \\\\\n\\hline ANBL0532 & 4 & 365-<547d & amp & any & any & \\\\\n\\hline ANBL0532 & 4 & 365-<547d & any & \\(D I = 1\\) & any & \\\\\n\\hline ANBL0532 & 4 & 365-<547d & any & any & UH & \\\\\n\\hline ANBL0531 & 4 & \\(365-<547 d\\) & not amp & DI \\(>1\\) & FH & \\\\\n\\hline ANBL0532 & 4 & \\(\\geq 547 d\\) & any & any & any & 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\\multicolumn{3}{|c|}{\\begin{tabular}{l}\n13-CIS RA PHARMACOKINETIC DATA COLLECTION FORM \\\\\nANBL0532 - Phase III Randomized Trial of Single vs. Tandem Myeloablative Consolidation Therapy for High-Risk Neuroblastoma\n\\end{tabular}} \\\\\n\\hline \\begin{tabular}{l}\nDATE OF SUBMISSION:\n\\begin{tabular}{|l|l|l|l|l|l|l|l|}\n\\hline & & & & & & & \\\\\n\\hline\n\\end{tabular} \\\\\n(Mm/dd/yyyy)\n\\end{tabular} & \\begin{tabular}{l}\n![](https://cdn.mathpix.com/cropped/7e9a11d0-792e-4d29-97ca-9108a5b06777-118.jpg?height=94\\&width=406\\&top_left_y=478\\&top_left_x=766) \\\\\n(Mm/dd/yyyy)\n\\end{tabular} & COG REG. 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Refer to Section 15.7 of the protocol for more details. \\\\\nPlease send this completed form with the sample to: \\\\\nC Patrick Reynolds, MD PhD \\\\\nCancer Center Core Labs STOP 9450 \\\\\nTexas Tech University Health Sciences Center \\\\\n3601 4th Street, Lubbock, TX 79430-6540 \\\\\nOffice Phone: 806-743-1558 \\\\\nEmail: Patrick.Reynolds@TTUHSC.edu \\\\\nLab phone: 806-743-2707 \\\\\nContact in lab: TITO WOODBURN \\\\\nEmail: TITO.WOODBURN@TTUHSC.EDU\n\\end{tabular}","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":3,"confidence":0.9709048404429268,"confidence_rate":0.9999511470232105},{"cnt":[[247,1771],[1267,1771],[1267,1810],[247,1810]],"region":{"top_left_x":246,"top_left_y":1771,"width":1021,"height":40},"line":94,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b38b99a690dc407bb8d6e9397549842b","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"INSTRUCTIONS FOR PK COLLECTION AND SHIPPING:","text_display":"INSTRUCTIONS FOR PK COLLECTION AND SHIPPING:","confidence":1,"confidence_rate":1},{"cnt":[[247,1817],[1756,1817],[1756,1849],[247,1849]],"region":{"top_left_x":246,"top_left_y":1816,"width":1511,"height":33},"line":95,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f7b47dfbc5c45deaac326179884391e","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"ALL SAMPLES MUST BE PROTECTED FROM LIGHT AT ALL TIMES BY WRAPPING IN","text_display":"\nALL SAMPLES MUST BE PROTECTED FROM LIGHT AT ALL TIMES BY WRAPPING IN","confidence":1,"confidence_rate":1},{"cnt":[[247,1858],[626,1858],[626,1894],[247,1894]],"region":{"top_left_x":246,"top_left_y":1857,"width":380,"height":38},"line":96,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92354a4715e942059a3a0990b5c50004","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"FOIL IMMEDIATELY.","text_display":" FOIL IMMEDIATELY.","confidence":0.99853515625,"confidence_rate":0.9999333695979722},{"cnt":[[247,1903],[1587,1903],[1587,1944],[247,1944]],"region":{"top_left_x":246,"top_left_y":1903,"width":1342,"height":42},"line":97,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef945c747ad9497e94ba7c5a6e67a345","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"The blood sample ( \\(5 ~ m L\\) ) will be collected into sodium heparin tubes \\(4\\) hours after","text_display":"\nThe blood sample ( \\(5 ~ m L\\) ) will be collected into sodium heparin tubes \\(4\\) hours after","confidence":0.9709048404429268,"confidence_rate":0.9997047754163877},{"cnt":[[247,1946],[1717,1946],[1717,1988],[247,1988]],"region":{"top_left_x":246,"top_left_y":1946,"width":1472,"height":42},"line":98,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ba6a52ba4bb4b1eac0b79584274606f","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"administration of cis-RA on Day 14 of Course 1 of cis-RA treatment. Refer to Section 15.7","text_display":" administration of cis-RA on Day 14 of Course 1 of cis-RA treatment. Refer to Section 15.7","confidence":0.9926822170382366,"confidence_rate":0.9999258139713244},{"cnt":[[247,1990],[769,1990],[769,2031],[247,2031]],"region":{"top_left_x":246,"top_left_y":1989,"width":523,"height":42},"line":99,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"656df44894ec43d0aebc8f1cc4b7f708","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"of the protocol for more details.","text_display":" of the protocol for more details.","confidence":1,"confidence_rate":1},{"cnt":[[247,2033],[1096,2033],[1096,2074],[247,2074]],"region":{"top_left_x":246,"top_left_y":2033,"width":850,"height":42},"line":100,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ea59863e796404dae474faa692057b2","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"Please send this completed form with the sample to:","text_display":"\nPlease send this completed form with the sample to:","confidence":1,"confidence_rate":1},{"cnt":[[247,2076],[695,2076],[695,2118],[247,2118]],"region":{"top_left_x":246,"top_left_y":2076,"width":449,"height":42},"line":101,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6493161ea684d73b64fc9309114b123","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"C Patrick Reynolds, MD PhD","text_display":"\nC Patrick Reynolds, MD PhD","confidence":1,"confidence_rate":1},{"cnt":[[247,2118],[816,2118],[816,2152],[247,2152]],"region":{"top_left_x":246,"top_left_y":2117,"width":571,"height":36},"line":102,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dab1f0bb8e164a4db4746f73869259f1","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"Cancer Center Core Labs STOP 9450","text_display":"\nCancer Center Core Labs STOP 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79430-6540","confidence":0.99609375,"confidence_rate":0.9999089832278327},{"cnt":[[247,2237],[671,2237],[671,2271],[247,2271]],"region":{"top_left_x":246,"top_left_y":2236,"width":426,"height":36},"line":105,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7072ddf06079474597ea4cc6b3b4055c","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"Office Phone: 806-743-1558","text_display":"\nOffice Phone: 806-743-1558","confidence":1,"confidence_rate":1},{"cnt":[[247,2276],[864,2276],[864,2317],[247,2317]],"region":{"top_left_x":246,"top_left_y":2275,"width":618,"height":42},"line":106,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a55da6bce9bb47ad88b56d041174db3e","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"Email: Patrick.Reynolds@TTUHSC.edu","text_display":"\nEmail: Patrick.Reynolds@TTUHSC.edu","confidence":0.99267578125,"confidence_rate":0.9998115261600659},{"cnt":[[247,2315],[639,2315],[639,2356],[247,2356]],"region":{"top_left_x":246,"top_left_y":2314,"width":393,"height":42},"line":107,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"300d0dd9f5f64fcd864d5411be411cdc","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"Lab phone: 806-743-2707","text_display":"\nLab phone: 806-743-2707","confidence":1,"confidence_rate":1},{"cnt":[[247,2358],[803,2358],[803,2395],[247,2395]],"region":{"top_left_x":246,"top_left_y":2357,"width":558,"height":38},"line":108,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63bdff418e9f4449a3ab1d0559bb56e1","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"Contact in lab: TITO WOODBURN","text_display":"\nContact in lab: TITO WOODBURN","confidence":1,"confidence_rate":1},{"cnt":[[247,2401],[955,2401],[955,2442],[247,2442]],"region":{"top_left_x":246,"top_left_y":2401,"width":709,"height":42},"line":109,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3000de3ef9d840d4b1ada9506682dfa7","type":"text","conversion_output":false,"parent_id":"9040f3d08fe5411aa3cebd27dd35ec24","text":"Email: TITO.WOODBURN@TTUHSC.EDU","text_display":"\nEmail: TITO.WOODBURN@TTUHSC.EDU","confidence":1,"confidence_rate":1},{"cnt":[[1732,2587],[1876,2587],[1876,2628],[1732,2628]],"region":{"top_left_x":1731,"top_left_y":2586,"width":145,"height":42},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d25075f4df3e4d2da9b25afe3132138f","type":"page_info","conversion_output":false,"text":"Page 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optional","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[105,309],[2666,309],[2666,1635],[105,1635]],"region":{"top_left_x":105,"top_left_y":309,"width":2562,"height":1326},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"109b6a3270b04b4c961a8ef653309fb0","type":"table","conversion_output":true,"children_ids":["4a163e98f82c4537a7edc67cb89a78c3","8e7ddc770870491cb14cbc5f62a09830","5e54e55820dc47f094f4794fcc581eea","5fc70cbe35ec4129898422a2e0eaef4e","571f450118c84e8aa109e0f3b7c49e34","e1940aa82029468fbbe27db5d3e48954","56b3916422c24182996d2664d0ada9b7","0ba57bab2de24abb819a25ad4ed22421","2e797d3f8e4647199d28d75a959dd076","56cc037ae3854c86b5bd68dc1271ecb1","1a245c1ba70f4e36ad8bb64bb058e470","be158abc892e48ecb552ff76f11588c2","230dd989426a4f649fd6d8059eff9201","9b0d3cd7f2f24636a82d05eb10ddc5da","7258a73fa57843b2bef4338b8996278a","1fe1e9f52bd04a50994199fb9475da73","fd85870801a842bea11f40836b6e8d2c","cf18f315fe1b4a849a0190c65fbd9183","0a9af214082241208dc8b4089ece4e8a","0bfd9b5b6e804ea58f192ea44084cf0a","d36e0f6d64a948a5a4f9f53eee6bc07e","a8983aad0b0246e88a402082d1f670ea","d2813ee7b38240ca939ccd292cc467bc","bbd328817ab843e7af2966e94dc31daf","5c831d2cb66e4372aafa2cd8cdc34a85","1a8553a061b347a5aaee651e15b2dcfb","292078324da74fd3984b5abc4115eef3","8859ce37cf624089b53f85f24a417b8c","c11c1aa394df4d9d9d9ec738ca882682","80e0296cac9c4e23a71cf1f2a1f3b588","7650b26ecd6f468892c788e9434e821e","da87fd24a668421faf4880ba79dcf6a8","82216df069cf45efada0b1d4814964e4","f9207d105e9245c895d6e4092f3d33bc","260a02e9e795468e921558cf4bf37e31","e67dba10d9f74e55b78cd0b5bba62795","cab0d1b70a4f4083883c15d16965d564","8aba3e6f8b33489a80379b259c7f58bd","67eefbcdfff6489ea804a8ff8add84f2","04902b3a5fea47f7ba1c402a28312400","3ca988b96a9c4458afa340d586569738","a9cfc0c6447a4e21bca3673f86bb12b2","02beee6c54144fce92af00fbf8b0d39c","ae4e217222a54871a02ba1c1a2380e8f","1092281f319041779e0a947b032dd345","7d2ee005fee74d2595f642a867b7136e"],"selected_labels":["af4668798cfd47329f8cb3181b19f355"],"text":"\\begin{tabular}{|l|l|l|l|l|}\n\\hline & \\begin{tabular}{l}\nImmunocytochemistry \\\\\nSections 15.4 \\\\\nOptional (BM at CHLA)\n\\end{tabular} & \\begin{tabular}{l}\nCellular Immunity (CHOP) \\\\\nSection 15.8 \\\\\nOptional\n\\end{tabular} & \\begin{tabular}{l}\nRT-PCR (BPC) Sections 15.4 \\& 15.6 \\\\\n** Contact BPC for questions regarding \\\\\nPAX Gene tubes Optional \\\\\nPlace in sodium heparin tube (green), mix and transfer to PAX tubes\n\\end{tabular} & Cyclophosphamide Pharmacogenomics (SCCA) Section 15.2 Optional \\\\\n\\hline Diagnosis & Bone marrow \\(5 m l\\) each side in sodium heparin tube (green) & Peripheral Blood 20 ml in sodium heparin tube & \\begin{tabular}{l}\n1. Bone marrow 0.5 ml in PAX** tube \\\\\n2. Peripheral blood 2ml in PAX tube\n\\end{tabular} & Peripheral Blood 10 ml in EDTA tube (purple) \\\\\n\\hline Induction Cycle 1, D1 Topotecan PKs Section 15.3 Optional & \\multicolumn{4}{|c|}{Contact St.Jude (Stewart Laboratory ) for Topotecan PK kit. If treatment starts before arrival of kit, access Memos on COG website (12-14-07b; 5-8-08b) for instructions on sample acquisition or contact Stewart lab at 901-595-2400. Peripheral blood 2 mL sodium heparin tube (green) 15 +/- 10 minutes after end of topotecan infusion. Send to: St Jude/ Stewart Lab.} \\\\\n\\hline Induction Cycle 2, D1 Topotecan PKs Section 15.3 Optional & \\multicolumn{4}{|l|}{Peripheral blood 2 mL sodium heparin tube (green) \\(15+/-10\\) minutes after end of topotecan infusion. Send to: St Jude/ Stewart Lab.} \\\\\n\\hline Induction Cycle 2, END and Day 1 of stem cell collection & & & \\begin{tabular}{l}\n1. Bone marrow 0.5 ml in PAX tube \\\\\n2.1 ml of PBSC product in 2 PAX tubes ( \\(0 . 5 ~ m l\\) each)\n\\end{tabular} & \\\\\n\\hline Surgery ( \\({ }^{\\text {nd }}\\) Look) & \\multicolumn{4}{|l|}{Required for ANBL00B1: Tumor Tissue to BPC. 1. 2 H\\&E slides from paraffin block; 2. Representative paraffin blocks or 10 unstained slides from most representative blocks on coated slides for IHC use. 3. Snap frozen tissue 4. Viable fresh tissue} \\\\\n\\hline Induction, End & Bone marrow \\(5 m l\\) each side in sodium heparin tubes & & \\begin{tabular}{l}\n1. Bone marrow 0.5 ml PAX tube \\\\\n2. Peripheral blood 2 ml in PAX tube\n\\end{tabular} & \\\\\n\\hline Consolidation, End & \\begin{tabular}{l}\nBone marrow 5 ml each side in sodium heparin tube (green) \\\\\nONLY IF ENROLLING onto ANBL0032 or ANBL0931\n\\end{tabular} & Peripheral Blood 20ml in sodium heparin tube 60-90D post HSCT & \\begin{tabular}{l}\n1. Bone marrow \\(0 . 5 m l\\) in PAX tube \\\\\n2. 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versus Two","confidence":1,"confidence_rate":1},{"cnt":[[645,486],[1476,486],[1476,531],[645,531]],"region":{"top_left_x":644,"top_left_y":485,"width":832,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d91736dd8c24496a1f2334e61d324a0","type":"text","conversion_output":true,"parent_id":"50980da1cd3c4d198b8bc315a0f34dfd","text":"High Dose Chemotherapy Regimens in Consolidation","text_display":" \\\\ High Dose Chemotherapy Regimens in Consolidation\n}","confidence":1,"confidence_rate":1},{"cnt":[[309,571],[1880,571],[1880,621],[309,621]],"region":{"top_left_x":309,"top_left_y":571,"width":1571,"height":50},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1ed44318ece482aaa5074a97dfe37cc","type":"text","conversion_output":true,"text":"1. We have been talking with you about neuroblastoma. Neuroblastoma is a type of cancer that","text_display":"\n1. We have been talking with you about neuroblastoma. Neuroblastoma is a type of cancer that","confidence":1,"confidence_rate":1},{"cnt":[[367,614],[1880,614],[1880,664],[367,664]],"region":{"top_left_x":367,"top_left_y":614,"width":1513,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c4cf1a6b75f4a2bb456a9b7a3d9b9f1","type":"text","conversion_output":true,"text":"grows mostly in the nervous system outside the brain. We have done special tests, scans and","text_display":" grows mostly in the nervous system outside the brain. We have done special tests, scans and","confidence":1,"confidence_rate":1},{"cnt":[[370,662],[1880,662],[1880,707],[370,707]],"region":{"top_left_x":369,"top_left_y":661,"width":1511,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e40939355f134de99c7d30eba8adae98","type":"text","conversion_output":true,"text":"blood tests on you to find out if you have high-risk neuroblastoma. The tests tell us that you have","text_display":" blood tests on you to find out if you have high-risk neuroblastoma. The tests tell us that you have","confidence":1,"confidence_rate":1},{"cnt":[[370,705],[1566,705],[1566,750],[370,750]],"region":{"top_left_x":369,"top_left_y":704,"width":1198,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34a2e246cc2f477a91005f3422cb44c6","type":"text","conversion_output":true,"text":"neuroblastoma that is hard to treat because it has spread from where it started.","text_display":" neuroblastoma that is hard to treat because it has spread from where it started.","confidence":1,"confidence_rate":1},{"cnt":[[305,791],[1880,791],[1880,838],[305,838]],"region":{"top_left_x":305,"top_left_y":790,"width":1575,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e1382bd174c4b07b901c85b2ee12bb8","type":"text","conversion_output":true,"text":"2. We are asking you to take part in a research study because you have the type of neuroblastoma","text_display":"\n2. We are asking you to take part in a research study because you have the type of neuroblastoma","confidence":1,"confidence_rate":1},{"cnt":[[370,836],[1880,836],[1880,883],[370,883]],"region":{"top_left_x":369,"top_left_y":835,"width":1511,"height":49},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd1896a56f514f21bf2a4375fd9c6712","type":"text","conversion_output":true,"text":"that is hard to treat. A research study is when doctors work together to try out new ways to help","text_display":" that is hard to treat. A research study is when doctors work together to try out new ways to help","confidence":1,"confidence_rate":1},{"cnt":[[370,881],[1880,881],[1880,926],[370,926]],"region":{"top_left_x":369,"top_left_y":880,"width":1511,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a5652fd000c44008956d59620cbc7d8","type":"text","conversion_output":true,"text":"people who are sick. In this study, we are trying to learn more about how to treat high-risk","text_display":" people who are sick. In this study, we are trying to learn more about how to treat high-risk","confidence":1,"confidence_rate":1},{"cnt":[[370,924],[926,924],[926,969],[370,969]],"region":{"top_left_x":369,"top_left_y":923,"width":557,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"282e8bf7583e4f47830aeb2936083805","type":"text","conversion_output":true,"text":"neuroblastoma. We will do this by:","text_display":" neuroblastoma. We will do this by:","confidence":1,"confidence_rate":1},{"cnt":[[432,967],[1880,967],[1880,1016],[432,1016]],"region":{"top_left_x":431,"top_left_y":966,"width":1449,"height":51},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ad33d5893c4472680c7db2cbd406a56","type":"text","conversion_output":true,"text":"a. adding a new anti-cancer medicine, called Topotecan, to the usual chemotherapy that","text_display":"\na. adding a new anti-cancer medicine, called Topotecan, to the usual chemotherapy that","confidence":1,"confidence_rate":1},{"cnt":[[494,1010],[1059,1010],[1059,1055],[494,1055]],"region":{"top_left_x":494,"top_left_y":1009,"width":566,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf4fb435853e4b9e9828356a2893e4d5","type":"text","conversion_output":true,"text":"children with neuroblastoma receive","text_display":" children with neuroblastoma receive","confidence":1,"confidence_rate":1},{"cnt":[[432,1055],[1880,1055],[1880,1102],[432,1102]],"region":{"top_left_x":431,"top_left_y":1054,"width":1449,"height":49},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"140d5180762b4e2d87428cd28b2ad253","type":"text","conversion_output":true,"text":"b. giving higher doses of radiation (or x-ray treatments) to children who still have tumor","text_display":"\nb. giving higher doses of radiation (or x-ray treatments) to children who still have tumor","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[494,1100],[1218,1100],[1218,1145],[494,1145]],"region":{"top_left_x":494,"top_left_y":1100,"width":725,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0c82373d512423b8494c454e1c7ff21","type":"text","conversion_output":true,"text":"after getting induction chemotherapy medicine","text_display":" after getting induction chemotherapy medicine","confidence":1,"confidence_rate":1},{"cnt":[[432,1143],[1880,1143],[1880,1190],[432,1190]],"region":{"top_left_x":431,"top_left_y":1142,"width":1449,"height":49},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0d239e7cfd743679ebf8d61dde0b211","type":"text","conversion_output":true,"text":"c. giving some children one cycle of high dose chemotherapy and some children two cycles","text_display":"\nc. giving some children one cycle of high dose chemotherapy and some children two cycles","confidence":1,"confidence_rate":1},{"cnt":[[494,1186],[1882,1186],[1882,1233],[494,1233]],"region":{"top_left_x":494,"top_left_y":1185,"width":1389,"height":49},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c03e1f7d428b47219527f5cf3fd73891","type":"text","conversion_output":true,"text":"of high dose chemotherapy, followed by either one or two stem cell transplants, to see if","text_display":" of high dose chemotherapy, followed by either one or two stem cell transplants, to see if","confidence":1,"confidence_rate":1},{"cnt":[[494,1231],[1687,1231],[1687,1278],[494,1278]],"region":{"top_left_x":494,"top_left_y":1231,"width":1193,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21dbfd24ba9140bf923fac926ae6c3e2","type":"text","conversion_output":true,"text":"this will keep the neuroblastoma from coming back after treatment is stopped","text_display":" this will keep the neuroblastoma from coming back after treatment is stopped","confidence":1,"confidence_rate":1},{"cnt":[[432,1276],[1291,1276],[1291,1321],[432,1321]],"region":{"top_left_x":431,"top_left_y":1276,"width":861,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07773b55c27c4b00b63cf99734e59c29","type":"text","conversion_output":true,"text":"d. studying how your body responds to the medicines.","text_display":"\nd. studying how your body responds to the medicines.","confidence":1,"confidence_rate":1},{"cnt":[[370,1319],[1880,1319],[1880,1364],[370,1364]],"region":{"top_left_x":369,"top_left_y":1319,"width":1511,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df36121a913641e99b2e71e13945bf11","type":"text","conversion_output":true,"text":"We want to see if these things can help more children can get rid of their neuroblastoma. We","text_display":"\n\nWe want to see if these things can help more children can get rid of their neuroblastoma. We","confidence":1,"confidence_rate":1},{"cnt":[[370,1362],[1680,1362],[1680,1412],[370,1412]],"region":{"top_left_x":369,"top_left_y":1362,"width":1312,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2331b1f339ad4bb2bcf0169d0f0e5824","type":"text","conversion_output":true,"text":"don't know if these approaches will help or not. That is why we are doing this study.","text_display":" don't know if these approaches will help or not. That is why we are doing this study.","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[305,1448],[1880,1448],[1880,1497],[305,1497]],"region":{"top_left_x":305,"top_left_y":1448,"width":1575,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"873128f36435435ca26c3f1a29b73df0","type":"text","conversion_output":true,"text":"3. Children who are part of this study will be treated first with chemotherapy that will include the","text_display":"\n3. Children who are part of this study will be treated first with chemotherapy that will include the","confidence":1,"confidence_rate":1},{"cnt":[[370,1495],[1880,1495],[1880,1540],[370,1540]],"region":{"top_left_x":369,"top_left_y":1495,"width":1511,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"922773a6e7d94e9fa699b8d655cb9f2e","type":"text","conversion_output":true,"text":"newer medicine, Topotecan, as well as several other chemotherapy medicines. Chemotherapy is","text_display":" newer medicine, Topotecan, as well as several other chemotherapy medicines. Chemotherapy is","confidence":1,"confidence_rate":1},{"cnt":[[370,1538],[1880,1538],[1880,1583],[370,1583]],"region":{"top_left_x":369,"top_left_y":1538,"width":1511,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06c3ad01baf641f19cd2fa1a1fb6b19a","type":"text","conversion_output":true,"text":"a type of medicine that destroys cancer cells. Some children may also have surgery or radiation to","text_display":" a type of medicine that destroys cancer cells. Some children may also have surgery or radiation to","confidence":1,"confidence_rate":1},{"cnt":[[370,1581],[1880,1581],[1880,1631],[370,1631]],"region":{"top_left_x":369,"top_left_y":1581,"width":1511,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f62ac7e6dde647e6bd7f3bb0b46ebcd6","type":"text","conversion_output":true,"text":"get rid of as much of the neuroblastoma as possible. After this first part of therapy, some children","text_display":" get rid of as much of the neuroblastoma as possible. After this first part of therapy, some children","confidence":1,"confidence_rate":1},{"cnt":[[370,1626],[1880,1626],[1880,1674],[370,1674]],"region":{"top_left_x":369,"top_left_y":1626,"width":1511,"height":48},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af384eba686d4fe8ab8534457ad7b662","type":"text","conversion_output":true,"text":"will get one cycle, while others may get two cycles of high dose chemotherapy followed by a","text_display":" will get one cycle, while others may get two cycles of high dose chemotherapy followed by a","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[370,1671],[1880,1671],[1880,1717],[370,1717]],"region":{"top_left_x":369,"top_left_y":1671,"width":1511,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"067f8ec2fcbb49f2b17170c012b18815","type":"text","conversion_output":true,"text":"stem cell transplant. All children in this study will get the medicine, Accutane, after the","text_display":" stem cell transplant. All children in this study will get the medicine, Accutane, after the","confidence":1,"confidence_rate":1},{"cnt":[[370,1714],[1880,1714],[1880,1760],[370,1760]],"region":{"top_left_x":369,"top_left_y":1714,"width":1511,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88b98dd115f649fc9c74c8fbcacb7c51","type":"text","conversion_output":true,"text":"chemotherapy, stem cell transplant, surgery and radiation are done. Sometimes you will have","text_display":" chemotherapy, stem cell transplant, surgery and radiation are done. Sometimes you will have","confidence":1,"confidence_rate":1},{"cnt":[[370,1757],[1051,1757],[1051,1807],[370,1807]],"region":{"top_left_x":369,"top_left_y":1757,"width":682,"height":50},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7318ecd6aded426a8c1647afab21df93","type":"text","conversion_output":true,"text":"extra blood drawn for special research tests.","text_display":" extra blood drawn for special research tests.","confidence":1,"confidence_rate":1},{"cnt":[[305,1843],[1880,1843],[1880,1893],[305,1893]],"region":{"top_left_x":305,"top_left_y":1843,"width":1575,"height":50},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa9407da231840da8b165dc0c75d6bf2","type":"text","conversion_output":true,"text":"4. Sometimes good things can happen to people when they are in a research study. These good","text_display":"\n4. Sometimes good things can happen to people when they are in a research study. 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The treatment is given in three phases: Induction,","confidence":1,"confidence_rate":1},{"cnt":[[370,1577],[1880,1577],[1880,1626],[370,1626]],"region":{"top_left_x":369,"top_left_y":1576,"width":1511,"height":51},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6bf9852785147fda297ff80b5aa423d","type":"text","conversion_output":true,"text":"Consolidation and Maintenance. Chemotherapy is a type of strong medicine that destroys cancer","text_display":" Consolidation and Maintenance. Chemotherapy is a type of strong medicine that destroys cancer","confidence":1,"confidence_rate":1},{"cnt":[[370,1624],[1880,1624],[1880,1669],[370,1669]],"region":{"top_left_x":369,"top_left_y":1624,"width":1511,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6f1d5723470445882def09aff18fcf7","type":"text","conversion_output":true,"text":"cells. The chemotherapy in this study is very strong and may make you feel pretty sick at times.","text_display":" cells. The chemotherapy in this study is very strong and may make you feel pretty sick at times.","confidence":1,"confidence_rate":1},{"cnt":[[370,1667],[1880,1667],[1880,1712],[370,1712]],"region":{"top_left_x":369,"top_left_y":1667,"width":1511,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab30e389531d4fcf8570b3891e84433c","type":"text","conversion_output":true,"text":"The doctors will give you medicines to help you when you are sick. You will be in the hospital a","text_display":" The doctors will give you medicines to help you when you are sick. You will be in the hospital a","confidence":1,"confidence_rate":1},{"cnt":[[370,1710],[1880,1710],[1880,1755],[370,1755]],"region":{"top_left_x":369,"top_left_y":1710,"width":1511,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fed4c48ffe84f3ab499c86880c19321","type":"text","conversion_output":true,"text":"lot to get the chemotherapy. In the induction phase, you will receive chemotherapy, including the","text_display":" lot to get the chemotherapy. In the induction phase, you will receive chemotherapy, including the","confidence":1,"confidence_rate":1},{"cnt":[[370,1753],[1880,1753],[1880,1800],[370,1800]],"region":{"top_left_x":369,"top_left_y":1753,"width":1511,"height":48},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1022c1cfc49f40df9196e2bf788614ef","type":"text","conversion_output":true,"text":"new combination, cyclophosphamide and topotecan and you will also have a procedure(s) called","text_display":" new combination, cyclophosphamide and topotecan and you will also have a procedure(s) called","confidence":1,"confidence_rate":1},{"cnt":[[370,1796],[1880,1796],[1880,1846],[370,1846]],"region":{"top_left_x":369,"top_left_y":1796,"width":1511,"height":50},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbe013a0fab44dd0b76da732e7e2d29e","type":"text","conversion_output":true,"text":"a stem cell harvest. You will be connected to a machine that will remove blood from you, take out","text_display":" a stem cell harvest. You will be connected to a machine that will remove blood from you, take out","confidence":1,"confidence_rate":1},{"cnt":[[370,1839],[1880,1839],[1880,1888],[370,1888]],"region":{"top_left_x":369,"top_left_y":1839,"width":1511,"height":50},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fcc21d468d394f58b3f0463519114b54","type":"text","conversion_output":true,"text":"the baby cells (stem cells) that grow up to be normal blood cells, and then give the rest of the","text_display":" the baby cells (stem cells) that grow up to be normal blood cells, and then give the rest of the","confidence":1,"confidence_rate":1},{"cnt":[[370,1886],[1880,1886],[1880,1931],[370,1931]],"region":{"top_left_x":369,"top_left_y":1886,"width":1511,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93b42ff08fbd4fd3890d6746c956eb31","type":"text","conversion_output":true,"text":"blood back to you. During consolidation, you will get either one or two cycles of very high doses","text_display":" blood back to you. During consolidation, you will get either one or two cycles of very high doses","confidence":1,"confidence_rate":1},{"cnt":[[370,1929],[1880,1929],[1880,1979],[370,1979]],"region":{"top_left_x":369,"top_left_y":1929,"width":1511,"height":50},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e88066a5b6eb40b0aa1926db26bc91ab","type":"text","conversion_output":true,"text":"of chemotherapy, followed by either one or two stem cell transplants. The last phase of therapy is","text_display":" of chemotherapy, followed by either one or two stem cell transplants. The last phase of therapy is","confidence":1,"confidence_rate":1},{"cnt":[[370,1972],[1880,1972],[1880,2022],[370,2022]],"region":{"top_left_x":369,"top_left_y":1972,"width":1511,"height":50},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd426460dc004900a05a6bf329923ec1","type":"text","conversion_output":true,"text":"called maintenance. During this phase you will be taking pills by mouth twice a day for two","text_display":" called maintenance. During this phase you will be taking pills by mouth twice a day for two","confidence":1,"confidence_rate":1},{"cnt":[[370,2020],[1878,2020],[1878,2065],[370,2065]],"region":{"top_left_x":369,"top_left_y":2019,"width":1509,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b173ab806354644a8edce5007b28451","type":"text","conversion_output":true,"text":"weeks. Then you will have 2 weeks that you do not take the pills. This phase lasts for six months.","text_display":" weeks. Then you will have 2 weeks that you do not take the pills. This phase lasts for six months.","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[370,2062],[1755,2062],[1755,2108],[370,2108]],"region":{"top_left_x":369,"top_left_y":2062,"width":1387,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b222480aadbb4bcf940e8a0d374b4ea2","type":"text","conversion_output":true,"text":"Throughout the treatment you will have some extra blood draws for special research tests.","text_display":" Throughout the treatment you will have some extra blood draws for special research tests.","confidence":1,"confidence_rate":1},{"cnt":[[292,2148],[1880,2148],[1880,2198],[292,2198]],"region":{"top_left_x":292,"top_left_y":2148,"width":1588,"height":50},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a67947832b4447885bbc23ccb087c74","type":"text","conversion_output":true,"text":"4. Sometimes good things can happen to people when they are in a research study. These good","text_display":"\n4. Sometimes good things can happen to people when they are in a research study. These good","confidence":1,"confidence_rate":1},{"cnt":[[370,2194],[1880,2194],[1880,2241],[370,2241]],"region":{"top_left_x":369,"top_left_y":2193,"width":1511,"height":48},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14b9841cbb1b48fd9aeb3f52e743cdf3","type":"text","conversion_output":true,"text":"things are called \"benefits.\" A benefit of being part of this study may be a chance that your","text_display":" things are called \"benefits.\" A benefit of being part of this study may be a chance that your","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[370,2239],[1884,2239],[1884,2284],[370,2284]],"region":{"top_left_x":369,"top_left_y":2238,"width":1516,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bea6fea395eb46eea0f0bbc7856aa7a8","type":"text","conversion_output":true,"text":"cancer will go away for as long as possible. We don't know for sure if there is any benefit of","text_display":" cancer will go away for as long as possible. We don't know for sure if there is any benefit of","confidence":1,"confidence_rate":1},{"cnt":[[370,2282],[1882,2282],[1882,2327],[370,2327]],"region":{"top_left_x":369,"top_left_y":2281,"width":1514,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e579b9bc7954aa98d5b7b7c20f5f350","type":"text","conversion_output":true,"text":"being part of this study. We expect that the information learned from this study will help other","text_display":" being part of this study. We expect that the information learned from this study will help other","confidence":1,"confidence_rate":1},{"cnt":[[370,2325],[1162,2325],[1162,2374],[370,2374]],"region":{"top_left_x":369,"top_left_y":2324,"width":794,"height":51},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a11fe4d6b90144f2942d1814a8e09af4","type":"text","conversion_output":true,"text":"patients with high-risk neuroblastoma in the future.","text_display":" patients with high-risk neuroblastoma in the future.","confidence":1,"confidence_rate":1},{"cnt":[[1727,2582],[1880,2582],[1880,2632],[1727,2632]],"region":{"top_left_x":1727,"top_left_y":2582,"width":153,"height":50},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3a3d27947934a7d985ef3c0a1382ca5","type":"page_info","conversion_output":false,"text":"Page 122","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-123","page":123,"lines":[{"cnt":[[245,122],[651,122],[651,236],[245,236]],"region":{"top_left_x":244,"top_left_y":122,"width":407,"height":115},"line":1,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"12461e8f29934871b83974623b2636d0","type":"page_info","conversion_output":false,"children_ids":["a9b3c5a9b41048e0bc48a59db5fede70","b23833480e9d4fe78864001be06242e0"],"text":"","text_display":""},{"cnt":[[249,125],[614,125],[614,191],[249,191]],"region":{"top_left_x":249,"top_left_y":124,"width":366,"height":68},"line":2,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"a9b3c5a9b41048e0bc48a59db5fede70","type":"text","conversion_output":false,"parent_id":"12461e8f29934871b83974623b2636d0","text":"CureSearch","text_display":"\nCureSearch","confidence":0.9970703125,"confidence_rate":0.9998044199659498},{"cnt":[[331,198],[651,198],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":197,"width":321,"height":33},"line":3,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b23833480e9d4fe78864001be06242e0","type":"text","conversion_output":false,"parent_id":"12461e8f29934871b83974623b2636d0","text":"Children's Oncology Group","text_display":"\nChildren's Oncology Group","confidence":1,"confidence_rate":1},{"cnt":[[653,129],[1648,129],[1648,163],[653,163]],"region":{"top_left_x":653,"top_left_y":128,"width":995,"height":36},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e5a3be66e03943a19472efff5fa30f46","type":"page_info","conversion_output":false,"text":"THIS PROTOCOL IS FOR RESEARCH PURPOSES ONLY, SEE PAGE 1 FOR USAGE POLICY","text_display":"","confidence":0.3872335437056247,"confidence_rate":0.9882109506727085},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7010949762342079b0abefae4c66fbe","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[296,254],[1878,254],[1878,299],[296,299]],"region":{"top_left_x":296,"top_left_y":253,"width":1582,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"828f7439554247458c4c32e49db427b8","type":"text","conversion_output":true,"text":"5. Sometimes bad things can happen to people when they are in a research study. These bad","text_display":"\n5. Sometimes bad things can happen to people when they are in a research study. These bad","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[370,296],[1878,296],[1878,342],[370,342]],"region":{"top_left_x":369,"top_left_y":296,"width":1509,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a46d3534bb445ed9d6d880ab6b99cc4","type":"text","conversion_output":true,"text":"things are called \"risks.\" With this treatment you can have problems, both during and","text_display":" things are called \"risks.\" With this treatment you can have problems, both during and","confidence":1,"confidence_rate":1},{"cnt":[[370,344],[1867,344],[1867,385],[370,385]],"region":{"top_left_x":369,"top_left_y":343,"width":1498,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc5cc58df36c4397981f1e64a9cc7911","type":"text","conversion_output":true,"text":"after the treatment. The risks to you from this study involve very low blood counts, possible","text_display":" after the treatment. The risks to you from this study involve very low blood counts, possible","confidence":1,"confidence_rate":1},{"cnt":[[370,387],[1876,387],[1876,430],[370,430]],"region":{"top_left_x":369,"top_left_y":386,"width":1507,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15b06ce85ebb4745b21270a74ae2c359","type":"text","conversion_output":true,"text":"infections and organ damage. You will be given medicines to help your blood counts recover","text_display":" infections and organ damage. You will be given medicines to help your blood counts recover","confidence":0.99267578125,"confidence_rate":0.9999226222303292},{"cnt":[[370,430],[1876,430],[1876,475],[370,475]],"region":{"top_left_x":369,"top_left_y":429,"width":1507,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7135c734db945c39a547c4bd9a25d72","type":"text","conversion_output":true,"text":"after the treatment, to prevent infection, and to reduce organ damage. There is also a","text_display":" after the treatment, to prevent infection, and to reduce organ damage. There is also a","confidence":1,"confidence_rate":1},{"cnt":[[370,473],[1878,473],[1878,518],[370,518]],"region":{"top_left_x":369,"top_left_y":472,"width":1509,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60b954c30e564f3ab8383b5472fc68aa","type":"text","conversion_output":true,"text":"chance of the cancer cells growing back. We will check you closely so we can treat the","text_display":" chance of the cancer cells growing back. We will check you closely so we can treat the","confidence":1,"confidence_rate":1},{"cnt":[[370,518],[1807,518],[1807,561],[370,561]],"region":{"top_left_x":369,"top_left_y":517,"width":1438,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef69c76b78d6406e9b83c34df1628c61","type":"text","conversion_output":true,"text":"problems you may have. Other things may happen to you that we don't yet know about.","text_display":" problems you may have. Other things may happen to you that we don't yet know about.","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[305,604],[1880,604],[1880,649],[305,649]],"region":{"top_left_x":305,"top_left_y":603,"width":1575,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae9a9b7a1e3349f4b10116ddfc3661d1","type":"text","conversion_output":true,"text":"6. Your family can choose to be part of this study or not. Your family can also decide to stop being","text_display":"\n6. Your family can choose to be part of this study or not. Your family can also decide to stop being","confidence":1,"confidence_rate":1},{"cnt":[[370,649],[1880,649],[1880,694],[370,694]],"region":{"top_left_x":369,"top_left_y":648,"width":1511,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a782c182df554c0b875781e4420472d5","type":"text","conversion_output":true,"text":"in this study at any time once you start. There may be other treatments for your illness that your","text_display":" in this study at any time once you start. There may be other treatments for your illness that your","confidence":1,"confidence_rate":1},{"cnt":[[370,692],[1691,692],[1691,737],[370,737]],"region":{"top_left_x":369,"top_left_y":691,"width":1322,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52299020aeb44f21854c58e828cc02d4","type":"text","conversion_output":true,"text":"doctor can tell you about. Make sure to ask your doctors any questions that you have.","text_display":" doctor can tell you about. Make sure to ask your doctors any questions that you have.","confidence":1,"confidence_rate":1},{"cnt":[[305,780],[1880,780],[1880,827],[305,827]],"region":{"top_left_x":305,"top_left_y":779,"width":1575,"height":49},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25dcc5ab62d34363860a620355178e9a","type":"text","conversion_output":true,"text":"7. We are asking your permission to collect additional blood and bone marrow specimens. We want","text_display":"\n7. We are asking your permission to collect additional blood and bone marrow specimens. We want","confidence":1,"confidence_rate":1},{"cnt":[[370,825],[1878,825],[1878,870],[370,870]],"region":{"top_left_x":369,"top_left_y":825,"width":1509,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a731dd5ca300406fbf13f1b5d80f422e","type":"text","conversion_output":true,"text":"to see if there are ways to tell how the cancer will respond to treatment. 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Neuroblastoma shows up as a lump or mass in the belly or","text_display":" Neuroblastoma is a type of cancer. Neuroblastoma shows up as a lump or mass in the belly or","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[1880,1753],[1880,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1753,"width":1636,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"026f3eb7d1cf40eba6dff2d54175bf91","type":"text","conversion_output":true,"text":"around the spinal cord in the chest, neck, or pelvis. Neuroblastoma is a cancer of nerve cells. It","text_display":" around the spinal cord in the chest, neck, or pelvis. Neuroblastoma is a cancer of nerve cells. 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Clinical trials include only people who choose to take part.","text_display":" improve cancer treatment over time. Clinical trials include only people who choose to take part.","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1880,2105],[1880,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2105,"width":1636,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54be4d5b5718484ea094fc30f0c3a8f4","type":"text","conversion_output":true,"text":"You have a choice between a standard treatment for High Risk neuroblastoma and this clinical","text_display":" You have a choice between a standard treatment for High Risk neuroblastoma and this clinical","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,2148],[1880,2148],[1880,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2148,"width":1636,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b01b69971ecf43af95cc9727447f8879","type":"text","conversion_output":true,"text":"trial. Please take your time to make your decision about taking part in this clinical trial. You may","text_display":" trial. Please take your time to make your decision about taking part in this clinical trial. You may","confidence":1,"confidence_rate":1},{"cnt":[[245,2191],[1878,2191],[1878,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2191,"width":1634,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a261d0a7d86e42229425ce05aa6b756a","type":"text","conversion_output":true,"text":"discuss your decision with your friends and family. You can also discuss it with your health care","text_display":" discuss your decision with your friends and family. 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If you have any questions, you can ask your","text_display":" she or he is able to understand and take part. If you have any questions, you can ask your","confidence":1,"confidence_rate":1},{"cnt":[[245,2325],[829,2325],[829,2370],[245,2370]],"region":{"top_left_x":244,"top_left_y":2324,"width":586,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffbf78c44cc94ef38de7805240034668","type":"text","conversion_output":true,"text":"study doctor for more explanation.","text_display":" study doctor for more explanation.","confidence":0.99951171875,"confidence_rate":0.9999874769887185},{"cnt":[[1732,2587],[1876,2587],[1876,2628],[1732,2628]],"region":{"top_left_x":1731,"top_left_y":2586,"width":145,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4eb67cb60e56404284dd052b30565f8c","type":"page_info","conversion_output":false,"text":"Page 131","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-132","page":132,"lines":[{"cnt":[[249,125],[612,125],[612,187],[249,187]],"region":{"top_left_x":249,"top_left_y":124,"width":364,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"f80d44b7281b46328501d2c958ad8faa","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1c00b5a7e7842fb828b1fd3427c2feb","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,200],[651,200],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":199,"width":321,"height":31},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d2d5e9e796f7411fa4814b03b75710d4","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,288],[1626,288],[1626,333],[243,333]],"region":{"top_left_x":242,"top_left_y":287,"width":1385,"height":47},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20e30fe0194549be8023fa3c7a9f3d4a","type":"section_header","conversion_output":false,"children_ids":["8985743833e7446390642711141d7c79"],"text":"","text_display":""},{"cnt":[[245,292],[1622,292],[1622,329],[245,329]],"region":{"top_left_x":244,"top_left_y":292,"width":1379,"height":37},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8985743833e7446390642711141d7c79","type":"text","conversion_output":true,"parent_id":"20e30fe0194549be8023fa3c7a9f3d4a","text":"WHAT IS THE CURRENT STANDARD OF TREATMENT FOR THIS DISEASE?","text_display":"\n\n\\section*{WHAT IS THE CURRENT STANDARD OF TREATMENT FOR THIS DISEASE?}","confidence":1,"confidence_rate":1},{"cnt":[[245,380],[1876,380],[1876,423],[245,423]],"region":{"top_left_x":244,"top_left_y":380,"width":1632,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"588b61c8bf284555a093493a595aa1d1","type":"text","conversion_output":true,"text":"The treatment for neuroblastoma includes 3 parts (phases) of therapy called Induction,","text_display":"\n\nThe treatment for neuroblastoma includes 3 parts (phases) of therapy called Induction,","confidence":1,"confidence_rate":1},{"cnt":[[247,423],[1878,423],[1878,468],[247,468]],"region":{"top_left_x":247,"top_left_y":423,"width":1631,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb2269d818b6410a8a5d2b31c934bbd0","type":"text","conversion_output":true,"text":"Consolidation and Maintenance. 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The extremely high doses of chemotherapy","text_display":" better kill any remaining neuroblastoma cells. The extremely high doses of chemotherapy","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,862],[1878,862],[1878,907],[245,907]],"region":{"top_left_x":244,"top_left_y":861,"width":1634,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2800c5e9bac84df1af2ba16768e75804","type":"text","conversion_output":true,"text":"destroy healthy bone marrow. Bone marrow is the soft tissue in the hollow of flat bones of the","text_display":" destroy healthy bone marrow. 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These stems cells allow the bone marrow to return to normal so that new blood","text_display":" chemotherapy. These stems cells allow the bone marrow to return to normal so that new blood","confidence":1,"confidence_rate":1},{"cnt":[[245,1038],[1878,1038],[1878,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1037,"width":1634,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e361dfce40b4b1082884bd806222de8","type":"text","conversion_output":true,"text":"cells can be made. This type of therapy is called a Hematopoietic Stem Cell Transplant. Once","text_display":" cells can be made. This type of therapy is called a Hematopoietic Stem Cell Transplant. 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the tumor was found and to any additional places where the tumor was","confidence":1,"confidence_rate":1},{"cnt":[[245,1169],[748,1169],[748,1216],[245,1216]],"region":{"top_left_x":244,"top_left_y":1168,"width":504,"height":49},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c654caee018846cc83c9ef0feeaaa401","type":"text","conversion_output":true,"text":"found after Induction therapy.","text_display":" found after Induction therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1257],[1880,1257],[1880,1304],[245,1304]],"region":{"top_left_x":244,"top_left_y":1256,"width":1636,"height":49},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f8df050ab0e4d45991e431655c4c646","type":"text","conversion_output":true,"text":"During the third phase of therapy, Maintenance, an oral drug, called cis-retinoic acid (Accutane)","text_display":"\n\nDuring the third phase of therapy, Maintenance, an oral drug, called cis-retinoic acid (Accutane)","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[393,1302],[393,1347],[245,1347]],"region":{"top_left_x":244,"top_left_y":1301,"width":150,"height":47},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddac14f5a25c4b15acd1cbadd7ec27a7","type":"text","conversion_output":true,"text":"is given.","text_display":" is 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This research study will also find out if adding a","text_display":" neuroblastoma will grow back after therapy. 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This research study will also find out if","text_display":" present at the end of the Induction phase of therapy. This research study will also find out if","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[1880,1826],[1880,1871],[245,1871]],"region":{"top_left_x":244,"top_left_y":1826,"width":1636,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f7032a317a84a0cbb5706de08a79d57","type":"text","conversion_output":true,"text":"patients whose tumor does not go away with initial therapy will need a higher dose of radiation","text_display":" patients whose tumor does not go away with initial therapy will need a higher dose of radiation","confidence":1,"confidence_rate":1},{"cnt":[[245,1869],[389,1869],[389,1914],[245,1914]],"region":{"top_left_x":244,"top_left_y":1869,"width":145,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed2694071c854898a79b22af9a65e31c","type":"text","conversion_output":true,"text":"therapy.","text_display":" therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1955],[1878,1955],[1878,2002],[245,2002]],"region":{"top_left_x":244,"top_left_y":1955,"width":1634,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a4d0fd12a3440289cd615cb3184dd55","type":"text","conversion_output":true,"text":"The treatment will be described in two separate consent forms. Part 1 will discuss the use of a","text_display":"\n\nThe treatment will be described in two separate consent forms. Part 1 will discuss the use of a","confidence":1,"confidence_rate":1},{"cnt":[[245,2002],[1878,2002],[1878,2047],[245,2047]],"region":{"top_left_x":244,"top_left_y":2002,"width":1634,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b695ce8b5064d4fbe9cdc9f2249486f","type":"text","conversion_output":true,"text":"drug added to the standard anti-cancer drugs used in the Induction phase of neuroblastoma","text_display":" drug added to the standard anti-cancer drugs used in the Induction phase of neuroblastoma","confidence":1,"confidence_rate":1},{"cnt":[[245,2045],[1880,2045],[1880,2090],[245,2090]],"region":{"top_left_x":244,"top_left_y":2045,"width":1636,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e807a71521384657a1c33f10c859355e","type":"text","conversion_output":true,"text":"treatment. It will also explain standard blood stem cell collection and surgery. Part 1 of the","text_display":" treatment. It will also explain standard blood stem cell collection and surgery. Part 1 of the","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,2088],[836,2088],[836,2136],[245,2136]],"region":{"top_left_x":244,"top_left_y":2088,"width":592,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5443c4b2049e44f4b75c82c3249c8a8e","type":"text","conversion_output":true,"text":"consent is being given to you now.","text_display":" consent is being given to you now.","confidence":1,"confidence_rate":1},{"cnt":[[245,2176],[1878,2176],[1878,2224],[245,2224]],"region":{"top_left_x":244,"top_left_y":2176,"width":1634,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"909686b544fa476386a1e02881e32808","type":"text","conversion_output":true,"text":"Your doctor will give you Part 2 (the second consent form) of the study to you after you have","text_display":"\n\nYour doctor will give you Part 2 (the second consent form) of the study to you after you have","confidence":1,"confidence_rate":1},{"cnt":[[245,2221],[1880,2221],[1880,2267],[245,2267]],"region":{"top_left_x":244,"top_left_y":2221,"width":1636,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9f79d434c5b4ee0a23e349181935f66","type":"text","conversion_output":true,"text":"completed the Induction phase of therapy. 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You can discuss this with your doctor and make that decision","text_display":" take part in Part 2 of the study. 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In addition to killing tumor","text_display":"\n\nAll people who get cancer treatment are at risk of having side effects. In addition to killing tumor","confidence":1,"confidence_rate":1},{"cnt":[[245,758],[1876,758],[1876,801],[245,801]],"region":{"top_left_x":244,"top_left_y":758,"width":1632,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8550f348c5c4deabe9e7c6095b002e5","type":"text","conversion_output":true,"text":"cells, cancer chemotherapy can damage normal tissue and produce side effects. Side effects","text_display":" cells, cancer chemotherapy can damage normal tissue and produce side effects. Side effects","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[1876,799],[1876,844],[245,844]],"region":{"top_left_x":244,"top_left_y":799,"width":1632,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d45e821684974a7ea75b4a5134dc4e4d","type":"text","conversion_output":true,"text":"are usually reversible when the medication is stopped but occasionally persist and cause","text_display":" are usually reversible when the medication is stopped but occasionally persist and cause","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[1538,842],[1538,883],[245,883]],"region":{"top_left_x":244,"top_left_y":842,"width":1295,"height":42},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c27cff55052f48109513f648043d9982","type":"text","conversion_output":true,"text":"serious complications. A person can die from these and other complications.","text_display":" serious complications. A person can die from these and other complications.","confidence":1,"confidence_rate":1},{"cnt":[[247,924],[1876,924],[1876,969],[247,969]],"region":{"top_left_x":247,"top_left_y":923,"width":1629,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c79f0661dec34a558be77803790c1266","type":"text","conversion_output":true,"text":"Common side effects include nausea, vomiting, hair loss, and fatigue. Drugs may be given to","text_display":"\n\nCommon side effects include nausea, vomiting, hair loss, and fatigue. Drugs may be given to","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1876,967],[1876,1010],[245,1010]],"region":{"top_left_x":244,"top_left_y":966,"width":1632,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53348dc1bc7a4a96ad32ef87414200fe","type":"text","conversion_output":true,"text":"prevent or decrease nausea and vomiting. Hair loss is usually temporary but on very rare","text_display":" prevent or decrease nausea and vomiting. Hair loss is usually temporary but on very rare","confidence":1,"confidence_rate":1},{"cnt":[[245,1008],[1876,1008],[1876,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1007,"width":1632,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c1bdf66860d4eebad7004d0f3a9d0b7","type":"text","conversion_output":true,"text":"occasions it may be permanent. Some chemotherapy may lead to sterility. Sterility is the","text_display":" occasions it may be permanent. Some chemotherapy may lead to sterility. Sterility is the","confidence":1,"confidence_rate":1},{"cnt":[[245,1048],[1876,1048],[1876,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1048,"width":1632,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05a149cc3ddc4dcb87c2ef8c9c4b3aad","type":"text","conversion_output":true,"text":"inability to have children. There is also the possibility that a second cancer may develop years","text_display":" inability to have children. There is also the possibility that a second cancer may develop years","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[1876,1091],[1876,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1091,"width":1632,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9568b1a5c42f49b4b0d2458f91568a44","type":"text","conversion_output":true,"text":"later as a result of the chemotherapy. The risks of the individual drugs given as standard","text_display":" later as a result of the chemotherapy. The risks of the individual drugs given as standard","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,1134],[1876,1134],[1876,1173],[245,1173]],"region":{"top_left_x":244,"top_left_y":1134,"width":1632,"height":40},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67325b0776684eb9bd2ab6b4fff67aa4","type":"text","conversion_output":true,"text":"treatment are listed on the tables in Attachment \\#1. Side effects can be increased when","text_display":" treatment are listed on the tables in Attachment \\#1. Side effects can be increased when","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[853,1173],[853,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1173,"width":609,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1af2fef058a4a0b8b730a5d7940efa3","type":"text","conversion_output":true,"text":"chemotherapy drugs are combined.","text_display":" chemotherapy drugs are combined.","confidence":1,"confidence_rate":1},{"cnt":[[245,1259],[1876,1259],[1876,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1258,"width":1632,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"275b3ac532c14f1ca04a72dcde983e14","type":"text","conversion_output":true,"text":"The most common serious side effect from cancer treatment is lowering of the number of blood","text_display":"\n\nThe most common serious side effect from cancer treatment is lowering of the number of blood","confidence":1,"confidence_rate":1},{"cnt":[[245,1300],[1876,1300],[1876,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1299,"width":1632,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"921fb5060a754733aa64320515aa0c4b","type":"text","conversion_output":true,"text":"cells resulting in anemia, increased chance of infection, and bleeding tendency. Low blood","text_display":" cells resulting in anemia, increased chance of infection, and bleeding tendency. Low blood","confidence":1,"confidence_rate":1},{"cnt":[[245,1341],[1880,1341],[1880,1386],[245,1386]],"region":{"top_left_x":244,"top_left_y":1340,"width":1636,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bef71fdb2384434792b7321df0ea01fa","type":"text","conversion_output":true,"text":"counts are described in your Family Handbook for Children with Cancer. You will be taught","text_display":" counts are described in your Family Handbook for Children with Cancer. You will be taught","confidence":1,"confidence_rate":1},{"cnt":[[245,1384],[1431,1384],[1431,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1383,"width":1187,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c1285f5c77d41c4be5d4c5b03322d98","type":"text","conversion_output":true,"text":"more about caring for your child when his or her blood counts are low.","text_display":" more about caring for your child when his or her blood counts are low.","confidence":1,"confidence_rate":1},{"cnt":[[245,1465],[1820,1465],[1820,1510],[245,1510]],"region":{"top_left_x":244,"top_left_y":1465,"width":1576,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9181d966d904eaf8532dc6a6cf71a74","type":"text","conversion_output":true,"text":"There is a risk that the treatment plan will not cure the cancer or that the cancer can go away","text_display":"\n\nThere is a risk that the treatment plan will not cure the cancer or that the cancer can go away","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1508],[1173,1508],[1173,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1508,"width":930,"height":42},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb99b26848264724a1dda04812232f54","type":"text","conversion_output":true,"text":"after the treatment and then come back at a later date.","text_display":" after the treatment and then come back at a later date.","confidence":1,"confidence_rate":1},{"cnt":[[245,1590],[580,1590],[580,1635],[245,1635]],"region":{"top_left_x":244,"top_left_y":1589,"width":337,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4de1a90cfb9148218ad3c5ebecacbc03","type":"section_header","conversion_output":false,"children_ids":["b75b62380ef249ba82855d545b4cc033"],"text":"","text_display":""},{"cnt":[[247,1590],[578,1590],[578,1635],[247,1635]],"region":{"top_left_x":247,"top_left_y":1589,"width":331,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b75b62380ef249ba82855d545b4cc033","type":"text","conversion_output":true,"parent_id":"4de1a90cfb9148218ad3c5ebecacbc03","text":"Reproductive risks:","text_display":"\n\n\\section*{Reproductive risks:}","confidence":1,"confidence_rate":1},{"cnt":[[249,1635],[1876,1635],[1876,1678],[249,1678]],"region":{"top_left_x":249,"top_left_y":1634,"width":1627,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85e0a2aae7ac43b3a12660faa55025b0","type":"text","conversion_output":true,"text":"Because the drugs and/or radiation therapy in this study can affect a developing fetus (unborn","text_display":"\n\nBecause the drugs and/or radiation therapy in this study can affect a developing fetus (unborn","confidence":1,"confidence_rate":1},{"cnt":[[249,1680],[1880,1680],[1880,1723],[249,1723]],"region":{"top_left_x":249,"top_left_y":1680,"width":1631,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41fb99013499478ebaa56a7246a1b12a","type":"text","conversion_output":true,"text":"baby in the womb), you should not become pregnant or father a baby while on this study. Ask","text_display":" baby in the womb), you should not become pregnant or father a baby while on this study. Ask","confidence":1,"confidence_rate":1},{"cnt":[[247,1723],[1880,1723],[1880,1764],[247,1764]],"region":{"top_left_x":247,"top_left_y":1723,"width":1633,"height":41},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b9fcdd1d6b843d5a0ac4f1f455692fe","type":"text","conversion_output":true,"text":"about counseling and more information about preventing pregnancy. The administration of","text_display":" about counseling and more information about preventing pregnancy. The administration of","confidence":1,"confidence_rate":1},{"cnt":[[247,1766],[1876,1766],[1876,1811],[247,1811]],"region":{"top_left_x":247,"top_left_y":1766,"width":1629,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ce695ddbcfb4c199586634073dfe82a","type":"text","conversion_output":true,"text":"chemotherapy described may cause infertility (being less able to produce a viable egg or sperm)","text_display":" chemotherapy described may cause infertility (being less able to produce a viable egg or sperm)","confidence":1,"confidence_rate":1},{"cnt":[[247,1809],[1876,1809],[1876,1854],[247,1854]],"region":{"top_left_x":247,"top_left_y":1808,"width":1629,"height":47},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d9921c73dde4bfaa716885bbae975b7","type":"text","conversion_output":true,"text":"or sterility (being unable to produce a viable egg or sperm). We will talk to males who have","text_display":" or sterility (being unable to produce a viable egg or sperm). We will talk to males who have","confidence":0.99609375,"confidence_rate":0.9999596513364917},{"cnt":[[249,1852],[904,1852],[904,1897],[249,1897]],"region":{"top_left_x":249,"top_left_y":1851,"width":656,"height":47},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8835af2ce6894810b8fa1df779885fc1","type":"text","conversion_output":true,"text":"reached puberty about sperm banking.","text_display":" reached puberty about sperm banking.","confidence":1,"confidence_rate":1},{"cnt":[[245,1934],[466,1934],[466,1979],[245,1979]],"region":{"top_left_x":244,"top_left_y":1933,"width":223,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"122b5a5c257646429535c941fa92801a","type":"section_header","conversion_output":false,"children_ids":["53d9c42edabc493baf8430288974dfe2"],"text":"","text_display":""},{"cnt":[[249,1938],[462,1938],[462,1979],[249,1979]],"region":{"top_left_x":249,"top_left_y":1937,"width":213,"height":42},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53d9c42edabc493baf8430288974dfe2","type":"text","conversion_output":true,"parent_id":"122b5a5c257646429535c941fa92801a","text":"For Women:","text_display":"\n\n\\section*{For Women:}","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[245,1979],[1880,1979],[1880,2022],[245,2022]],"region":{"top_left_x":244,"top_left_y":1978,"width":1636,"height":44},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee02ec6ab5f248098652b426e032f4cd","type":"text","conversion_output":true,"text":"The treatment on this study can affect an unborn child. You should not become pregnant or","text_display":"\n\nThe treatment on this study can affect an unborn child. You should not become pregnant or","confidence":1,"confidence_rate":1},{"cnt":[[247,2020],[1878,2020],[1878,2065],[247,2065]],"region":{"top_left_x":247,"top_left_y":2019,"width":1631,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"036549a134134d5dbd5ed6f99e0321d5","type":"text","conversion_output":true,"text":"breast feed your baby while being treated on this study. If you are sexually active and are at risk","text_display":" breast feed your baby while being treated on this study. If you are sexually active and are at risk","confidence":1,"confidence_rate":1},{"cnt":[[245,2062],[1876,2062],[1876,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2062,"width":1632,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fe7bac593b04d9fb88fe0695a3ff999","type":"text","conversion_output":true,"text":"of getting pregnant, you and your male partner(s) must use an effective method to avoid","text_display":" of getting pregnant, you and your male partner(s) must use an effective method to avoid","confidence":1,"confidence_rate":1},{"cnt":[[247,2105],[1876,2105],[1876,2148],[247,2148]],"region":{"top_left_x":247,"top_left_y":2105,"width":1629,"height":44},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f18be65620914bf29337b88acd06dce6","type":"text","conversion_output":true,"text":"pregnancy or you must not have sex. The study doctor will talk to you about acceptable","text_display":" pregnancy or you must not have sex. The study doctor will talk to you about acceptable","confidence":1,"confidence_rate":1},{"cnt":[[247,2144],[1876,2144],[1876,2189],[247,2189]],"region":{"top_left_x":247,"top_left_y":2144,"width":1629,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b65a64d114d4bc994a386be246fddaa","type":"text","conversion_output":true,"text":"methods to avoid pregnancy while you are being treated on this study. You will have to use the","text_display":" methods to avoid pregnancy while you are being treated on this study. You will have to use the","confidence":1,"confidence_rate":1},{"cnt":[[247,2187],[1876,2187],[1876,2232],[247,2232]],"region":{"top_left_x":247,"top_left_y":2187,"width":1629,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5904fa23740d43e39b342402c8e8c03a","type":"text","conversion_output":true,"text":"chosen method to avoid pregnancy or abstain (not have sexual intercourse) the whole time you","text_display":" chosen method to avoid pregnancy or abstain (not have sexual intercourse) the whole time you","confidence":1,"confidence_rate":1},{"cnt":[[247,2230],[1876,2230],[1876,2273],[247,2273]],"region":{"top_left_x":247,"top_left_y":2230,"width":1629,"height":44},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cedfee74a354254a79484e8042fc4c0","type":"text","conversion_output":true,"text":"are being treated on this study. You may need to continue this for a while, even after you finish","text_display":" are being treated on this study. You may need to continue this for a while, even after you finish","confidence":1,"confidence_rate":1},{"cnt":[[245,2271],[1876,2271],[1876,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2270,"width":1632,"height":44},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa47b0c566a74391bd02dcc572ce9f2a","type":"text","conversion_output":true,"text":"the cancer treatment, so talk to your doctor about the length of time you need to avoid","text_display":" the cancer treatment, so talk to your doctor about the length of time you need to avoid","confidence":1,"confidence_rate":1},{"cnt":[[247,2312],[1876,2312],[1876,2357],[247,2357]],"region":{"top_left_x":247,"top_left_y":2311,"width":1629,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0773e64ea864093863ef9df1e5b6433","type":"text","conversion_output":true,"text":"pregnancy or abstain. Natural family planning and the rhythm method will not be permissible","text_display":" pregnancy or abstain. Natural family planning and the rhythm method will not be permissible","confidence":1,"confidence_rate":1},{"cnt":[[247,2355],[1878,2355],[1878,2398],[247,2398]],"region":{"top_left_x":247,"top_left_y":2354,"width":1631,"height":44},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"584acb837ef448e2b09c926cc541cd7b","type":"text","conversion_output":true,"text":"means of avoiding pregnancy during study participation. If you have questions about this or","text_display":" means of avoiding pregnancy during study participation. If you have questions about this or","confidence":1,"confidence_rate":1},{"cnt":[[245,2396],[1876,2396],[1876,2443],[245,2443]],"region":{"top_left_x":244,"top_left_y":2395,"width":1632,"height":48},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00f8c5faa5bc4524a00b0f85afe88842","type":"text","conversion_output":true,"text":"want to change your method to avoid pregnancy during therapy, please ask your doctor. If you","text_display":" want to change your method to avoid pregnancy during therapy, please ask your doctor. 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You","text_display":"\n\nIf you are nursing a baby, the drugs used in this research could pass into the breast milk. You","confidence":1,"confidence_rate":1},{"cnt":[[247,421],[1878,421],[1878,466],[247,466]],"region":{"top_left_x":247,"top_left_y":421,"width":1631,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2adff6e8b45e4b819bacd6ab2099752e","type":"text","conversion_output":true,"text":"should not nurse your baby for the whole time you are getting the study medicines. You may","text_display":" should not nurse your baby for the whole time you are getting the study medicines. You may","confidence":1,"confidence_rate":1},{"cnt":[[247,466],[1880,466],[1880,509],[247,509]],"region":{"top_left_x":247,"top_left_y":466,"width":1633,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7b6cb1880ad407f95045cde43902a98","type":"text","conversion_output":true,"text":"need to continue this for a while, even after you finish the cancer treatment, so talk to your","text_display":" need to continue this for a while, even after you finish the cancer treatment, so talk to your","confidence":1,"confidence_rate":1},{"cnt":[[247,509],[1227,509],[1227,554],[247,554]],"region":{"top_left_x":247,"top_left_y":509,"width":980,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f935cb82e2ce4d3da01ad9ffd01cdd93","type":"text","conversion_output":true,"text":"doctor about the length of time you need to avoid nursing.","text_display":" doctor about the length of time you need to avoid nursing.","confidence":1,"confidence_rate":1},{"cnt":[[245,589],[406,589],[406,638],[245,638]],"region":{"top_left_x":244,"top_left_y":588,"width":163,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0a8ae5f679344f89cb772e28e687260","type":"section_header","conversion_output":false,"children_ids":["ba42007b0cd948dab7830b7165f4b433"],"text":"","text_display":""},{"cnt":[[249,593],[404,593],[404,634],[249,634]],"region":{"top_left_x":249,"top_left_y":592,"width":155,"height":42},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba42007b0cd948dab7830b7165f4b433","type":"text","conversion_output":true,"parent_id":"a0a8ae5f679344f89cb772e28e687260","text":"For Men:","text_display":"\n\n\\section*{For Men:}","confidence":1,"confidence_rate":1},{"cnt":[[245,636],[1876,636],[1876,677],[245,677]],"region":{"top_left_x":244,"top_left_y":635,"width":1632,"height":42},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4bc08868c344955b4e554dc15ddcf73","type":"text","conversion_output":true,"text":"The treatment on this study can damage sperm. You should not father a child while on this","text_display":"\n\nThe treatment on this study can damage sperm. You should not father a child while on this","confidence":1,"confidence_rate":1},{"cnt":[[245,677],[1880,677],[1880,720],[245,720]],"region":{"top_left_x":244,"top_left_y":676,"width":1636,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7590ea8026e04026afa57fab558ee3f3","type":"text","conversion_output":true,"text":"study as the treatment may indirectly affect an unborn child. If you are sexually active and are at","text_display":" study as the treatment may indirectly affect an unborn child. 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The investigator will talk to you about the","text_display":" pregnancy that works well or you must not have sex. The investigator will talk to you about the","confidence":1,"confidence_rate":1},{"cnt":[[245,801],[1876,801],[1876,844],[245,844]],"region":{"top_left_x":244,"top_left_y":801,"width":1632,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a57456d3cbdb459e91a078d07b1e0e52","type":"text","conversion_output":true,"text":"acceptable methods to avoid pregnancy while you are being treated on this study. You will have","text_display":" acceptable methods to avoid pregnancy while you are being treated on this study. You will have","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[1878,842],[1878,887],[245,887]],"region":{"top_left_x":244,"top_left_y":842,"width":1634,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d955d7745934713bfa554b6c2575342","type":"text","conversion_output":true,"text":"to use the chosen method to avoid pregnancy or abstain (not have sexual intercourse) the","text_display":" to use the chosen method to avoid pregnancy or abstain (not have sexual intercourse) the","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1876,885],[1876,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1632,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39ae0a75e3de416ba3925a55d3a69b9c","type":"text","conversion_output":true,"text":"whole time you are being treated on this study. You may need to continue this for a while, even","text_display":" whole time you are being treated on this study. You may need to continue this for a while, even","confidence":1,"confidence_rate":1},{"cnt":[[245,924],[1878,924],[1878,969],[245,969]],"region":{"top_left_x":244,"top_left_y":923,"width":1634,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6df535b251246589a90b4f56a449530","type":"text","conversion_output":true,"text":"after you finish the cancer treatment, so talk to your doctor about the length of time you need to","text_display":" after you finish the cancer treatment, so talk to your doctor about the length of time you need to","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1878,967],[1878,1012],[245,1012]],"region":{"top_left_x":244,"top_left_y":966,"width":1634,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f2b27cce43c41569ec6fd80534a12fe","type":"text","conversion_output":true,"text":"avoid pregnancy or abstain. Natural family planning and the rhythm method will not be","text_display":" avoid pregnancy or abstain. Natural family planning and the rhythm method will not be","confidence":1,"confidence_rate":1},{"cnt":[[245,1010],[1878,1010],[1878,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1009,"width":1634,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"266edd5f9e8a4d7dbaacbd2b20500433","type":"text","conversion_output":true,"text":"permissible means of avoiding pregnancy during study participation. If you have questions","text_display":" permissible means of avoiding pregnancy during study participation. If you have questions","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1880,1053],[1880,1096],[245,1096]],"region":{"top_left_x":244,"top_left_y":1052,"width":1636,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48cc397293f84513bf4582e4ea3af66e","type":"text","conversion_output":true,"text":"about this or want to change your method to avoid pregnancy during therapy, please ask your","text_display":" about this or want to change your method to avoid pregnancy during therapy, please ask your","confidence":1,"confidence_rate":1},{"cnt":[[245,1091],[1880,1091],[1880,1137],[245,1137]],"region":{"top_left_x":244,"top_left_y":1091,"width":1636,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33ce5af2b11a4577b0a622c0bf1af272","type":"text","conversion_output":true,"text":"doctor. If your partner becomes pregnant during the research study, please tell the investigator","text_display":" doctor. If your partner becomes pregnant during the research study, please tell the investigator","confidence":1,"confidence_rate":1},{"cnt":[[245,1134],[741,1134],[741,1179],[245,1179]],"region":{"top_left_x":244,"top_left_y":1134,"width":498,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2126a84c3bd436ca5e941aed61c9d9c","type":"text","conversion_output":true,"text":"and your doctor immediately.","text_display":" and your doctor immediately.","confidence":1,"confidence_rate":1},{"cnt":[[245,1222],[501,1222],[501,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1222,"width":257,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b654f3ebfce4e2aaa98c09b4fed9f20","type":"section_header","conversion_output":false,"children_ids":["92457c6b03564e7b90371c778d0597d4"],"text":"","text_display":""},{"cnt":[[249,1225],[501,1225],[501,1270],[249,1270]],"region":{"top_left_x":249,"top_left_y":1224,"width":252,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92457c6b03564e7b90371c778d0597d4","type":"text","conversion_output":true,"parent_id":"9b654f3ebfce4e2aaa98c09b4fed9f20","text":"Risks of Study","text_display":"\n\n\\section*{Risks of Study}","confidence":1,"confidence_rate":1},{"cnt":[[247,1268],[1807,1268],[1807,1315],[247,1315]],"region":{"top_left_x":247,"top_left_y":1267,"width":1560,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e58d87f1b5f43ceb8eda71c098ed18c","type":"text","conversion_output":true,"text":"The use of the topotecan/cyclophosphamide combination may lead to increased side effects","text_display":"\n\nThe use of the topotecan/cyclophosphamide combination may lead to increased side effects","confidence":1,"confidence_rate":1},{"cnt":[[245,1315],[885,1315],[885,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1314,"width":642,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ff0bad146b8424aaf4b9ae24fcc3e5d","type":"text","conversion_output":true,"text":"compared to standard chemotherapy.","text_display":" compared to standard chemotherapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1708,1401],[1708,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1400,"width":1465,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a183506e99ca46e8a429da415e693ce4","type":"text","conversion_output":true,"text":"The use of topotecan/cyclophosphamide may not work as well as the current standard","text_display":"\n\nThe use of topotecan/cyclophosphamide may not work as well as the current standard","confidence":1,"confidence_rate":1},{"cnt":[[245,1446],[423,1446],[423,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1445,"width":180,"height":40},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddf1c485619944da85fef50adc8fb932","type":"text","conversion_output":true,"text":"treatment.","text_display":" treatment.","confidence":1,"confidence_rate":1},{"cnt":[[247,1534],[1818,1534],[1818,1579],[247,1579]],"region":{"top_left_x":247,"top_left_y":1533,"width":1571,"height":47},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03227783b1c348aca96da465e141e846","type":"text","conversion_output":true,"text":"In addition to the risks described above, there may be unknown risks, or risks that we did not","text_display":"\n\nIn addition to the risks described above, there may be unknown risks, or risks that we did not","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1025,1577],[1025,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1576,"width":781,"height":47},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1855236186d84ee8b419f05d9ef42c6a","type":"text","conversion_output":true,"text":"anticipate, associated with being in this study.","text_display":" anticipate, associated with being in this study.","confidence":1,"confidence_rate":1},{"cnt":[[247,1712],[1648,1712],[1648,1757],[247,1757]],"region":{"top_left_x":247,"top_left_y":1712,"width":1401,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8409e0ee725749c4b56449b7849b081c","type":"figure_label","conversion_output":false,"text":"Risks and side effects related to cyclophosphamide include those which are:","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[226,1753],[1850,1753],[1850,2499],[226,2499]],"region":{"top_left_x":225,"top_left_y":1753,"width":1625,"height":746},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"868961ad6a484521aa97eaf8a1db4235","type":"table","conversion_output":true,"children_ids":["7d8935536edc4635b4627c8c9c050bfa","64a2a23ce1104c3f9bcb2147696ffa67","4cdc1de57a3e4295acb45b6b5bc0cf2e","c7fb37d848df4d399b8a2c30abfe109b","b22d4874e46c409396f898465b1d992f","7483da5a4b314de4a47e982ac05543d1","8bd098dfdb9743e0ac041077f7579181","7ffe8fe16c574cda9867860f082cb8b1","65f1f766a40f44939d991d00373deda9","915ecd0c01cf4b0084a80896a37e1c4c","761b1f321c7240bfaad4481284226ee6"],"selected_labels":["8409e0ee725749c4b56449b7849b081c"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Likely & Less Likely & Rare But Serious \\\\\n\\hline \\begin{tabular}{l}\n- Loss of appetite \\\\\n- Nausea \\\\\n- Vomiting \\\\\n- Fewer white blood cells in the blood. \\\\\n- A low number of white blood cells may make it easier to get infections. \\\\\n- Hair loss \\\\\n- Decreased ability of the body to fight infection \\\\\n- Absence or decrease in the number of sperm which may be temporary or permanent which may decrease the ability to\n\\end{tabular} & \\begin{tabular}{l}\n- Abnormal hormone function which may lower the level of salt in the blood \\\\\n- Abdominal pain \\\\\n- Diarrhea \\\\\n- Fewer red blood cells and platelets in the blood \\\\\n- A low number of red blood cells may make you feel tired and weak. \\\\\n- A low number of platelets may cause you to bruise and bleed more easily. \\\\\n- Bleeding and\n\\end{tabular} & \\begin{tabular}{l}\n- Heart muscle damage which may occur with very high doses and which may be fatal \\\\\n- Abnormal heart rhythms \\\\\n- Damage and scarring of lung tissue which may make you short of breath \\\\\n- A new cancer or leukemia resulting from this treatment. \\\\\n- Damage or 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You have the","confidence":1,"confidence_rate":1},{"cnt":[[245,1828],[1880,1828],[1880,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1828,"width":1636,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c020f2775fdd45689792bd000a3d6804","type":"text","conversion_output":true,"text":"type of neuroblastoma that is called High Risk because your tumor has spread from where it","text_display":" type of neuroblastoma that is called High Risk because your tumor has spread from where it","confidence":1,"confidence_rate":1},{"cnt":[[245,1873],[1274,1873],[1274,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1873,"width":1031,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe3a1dae8e3a46a688781c40cd13e586","type":"text","conversion_output":true,"text":"started from or because your type of tumor is harder to treat.","text_display":" started from or because your type of tumor is harder to treat.","confidence":1,"confidence_rate":1},{"cnt":[[245,1959],[1878,1959],[1878,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1959,"width":1634,"height":42},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11bab05077b8484aacf8f2cb22276db3","type":"text","conversion_output":true,"text":"It is common to enroll children and adolescents with cancer in a clinical trial that seeks to","text_display":"\n\nIt is common to enroll children and adolescents with cancer in a clinical trial that seeks to","confidence":1,"confidence_rate":1},{"cnt":[[245,2002],[1876,2002],[1876,2047],[245,2047]],"region":{"top_left_x":244,"top_left_y":2002,"width":1632,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0249db049b54f2c90a3aa4f06b77d5c","type":"text","conversion_output":true,"text":"improve cancer treatment over time. Clinical trials include only people who choose to take part.","text_display":" improve cancer treatment over time. Clinical trials include only people who choose to take part.","confidence":1,"confidence_rate":1},{"cnt":[[245,2050],[1880,2050],[1880,2093],[245,2093]],"region":{"top_left_x":244,"top_left_y":2049,"width":1636,"height":44},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2207810a9e34f078309bd1c81174519","type":"text","conversion_output":true,"text":"You have a choice between a standard treatment for High Risk neuroblastoma and this clinical","text_display":" You have a choice between a standard treatment for High Risk neuroblastoma and this clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1880,2093],[1880,2138],[245,2138]],"region":{"top_left_x":244,"top_left_y":2092,"width":1636,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6078361658f44c07ba3d68e5c30d8cab","type":"text","conversion_output":true,"text":"trial. Please take your time to make your decision about taking part in this clinical trial. You may","text_display":" trial. Please take your time to make your decision about taking part in this clinical trial. You may","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[1880,2136],[1880,2181],[245,2181]],"region":{"top_left_x":244,"top_left_y":2135,"width":1636,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61e21e6b691e4d389b4b4362f6510fda","type":"text","conversion_output":true,"text":"discuss your decision with your friends and family. You can also discuss it with your health care","text_display":" discuss your decision with your friends and family. You can also discuss it with your health care","confidence":1,"confidence_rate":1},{"cnt":[[245,2179],[1880,2179],[1880,2224],[245,2224]],"region":{"top_left_x":244,"top_left_y":2178,"width":1636,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f41e48ffaeb940e281c5cf1d92de8f1c","type":"text","conversion_output":true,"text":"team. We encourage you to include your child in the discussion and decision to the extent that","text_display":" team. We encourage you to include your child in the discussion and decision to the extent that","confidence":1,"confidence_rate":1},{"cnt":[[245,2224],[1880,2224],[1880,2271],[245,2271]],"region":{"top_left_x":244,"top_left_y":2223,"width":1636,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17c8de733439420fbe7c5d60bd4f8ec3","type":"text","conversion_output":true,"text":"she or he is able to understand and take part. If you have any questions, you can ask your","text_display":" she or he is able to understand and take part. If you have any questions, you can ask your","confidence":1,"confidence_rate":1},{"cnt":[[245,2269],[831,2269],[831,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2268,"width":588,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1453591bdcf84683b9d9e0a12659ae5b","type":"text","conversion_output":true,"text":"study doctor for more explanation.","text_display":" study doctor for more explanation.","confidence":0.99951171875,"confidence_rate":0.9999874769887185},{"cnt":[[241,2346],[1626,2346],[1626,2393],[241,2393]],"region":{"top_left_x":240,"top_left_y":2346,"width":1387,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a48c6f2a4aee41f8bb0b60d1ed25d44f","type":"section_header","conversion_output":false,"children_ids":["a0b34a466ca84bf386bbc04e7f11efe0"],"text":"","text_display":""},{"cnt":[[245,2350],[1622,2350],[1622,2391],[245,2391]],"region":{"top_left_x":244,"top_left_y":2350,"width":1379,"height":42},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0b34a466ca84bf386bbc04e7f11efe0","type":"text","conversion_output":true,"parent_id":"a48c6f2a4aee41f8bb0b60d1ed25d44f","text":"WHAT IS THE CURRENT STANDARD OF TREATMENT FOR THIS DISEASE?","text_display":"\n\n\\section*{WHAT IS THE CURRENT STANDARD OF TREATMENT FOR THIS DISEASE?}","confidence":1,"confidence_rate":1},{"cnt":[[245,2396],[1876,2396],[1876,2441],[245,2441]],"region":{"top_left_x":244,"top_left_y":2395,"width":1632,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a96eca4532134c48916ae95fab0b3542","type":"text","conversion_output":true,"text":"The treatment for neuroblastoma includes 3 parts (phases) of therapy called Induction,","text_display":"\n\nThe treatment for neuroblastoma includes 3 parts (phases) of therapy called Induction,","confidence":1,"confidence_rate":1},{"cnt":[[245,2441],[1880,2441],[1880,2486],[245,2486]],"region":{"top_left_x":244,"top_left_y":2440,"width":1636,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ff6593e89a3476c8e634ef89fbe5c89","type":"text","conversion_output":true,"text":"Consolidation and Maintenance. During Induction therapy anti-cancer drugs (chemotherapy)","text_display":" Consolidation and Maintenance. During Induction therapy anti-cancer drugs (chemotherapy)","confidence":1,"confidence_rate":1},{"cnt":[[1732,2587],[1876,2587],[1876,2628],[1732,2628]],"region":{"top_left_x":1731,"top_left_y":2586,"width":145,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e9141e986634d6f8f15b94e17d52647","type":"page_info","conversion_output":false,"text":"Page 152","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-153","page":153,"lines":[{"cnt":[[249,125],[612,125],[612,187],[249,187]],"region":{"top_left_x":249,"top_left_y":124,"width":364,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"e421b923f6724ed4836234b81f152187","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e56906bbdc34b32ac17471b56edcc8f","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,200],[651,200],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":199,"width":321,"height":31},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"36ad35b07a1149cdb2ed3d2dc8301eef","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,254],[1876,254],[1876,296],[245,296]],"region":{"top_left_x":244,"top_left_y":253,"width":1632,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c05d6f31bf9644ee8d30c85af8c6d57d","type":"text","conversion_output":true,"text":"and surgery are used to kill and remove as much tumor as possible. Blood stem cells are","text_display":"\nand surgery are used to kill and remove as much tumor as possible. Blood stem cells are","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1876,296],[1876,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1632,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a2985ac21534f548813b70172d70709","type":"text","conversion_output":true,"text":"collected during the Induction phase of therapy. After collection the blood stem cells are frozen","text_display":" collected during the Induction phase of therapy. After collection the blood stem cells are frozen","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1876,339],[1876,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1632,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39d2ce795da543c69e6e7117ec325bb4","type":"text","conversion_output":true,"text":"and stored to be used during Consolidation phase of treatment. Blood stem cells are the cells","text_display":" and stored to be used during Consolidation phase of treatment. Blood stem cells are the cells","confidence":1,"confidence_rate":1},{"cnt":[[245,382],[1876,382],[1876,428],[245,428]],"region":{"top_left_x":244,"top_left_y":382,"width":1632,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"041fe10a715d495abde88c3f06328c0f","type":"text","conversion_output":true,"text":"that create new blood cells, such as red blood cells, white blood cells, and platelets. Blood stem","text_display":" that create new blood cells, such as red blood cells, white blood cells, and platelets. Blood stem","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1876,425],[1876,471],[245,471]],"region":{"top_left_x":244,"top_left_y":425,"width":1632,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f2c0884e0604af194cfd0e19e8fe51f","type":"text","conversion_output":true,"text":"cells can be collected from the blood by using a machine that can separate out the part of blood","text_display":" cells can be collected from the blood by using a machine that can separate out the part of blood","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1878,473],[1878,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1634,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a84ef554e5bd4af1bb2e82454845d14b","type":"text","conversion_output":true,"text":"that has stem cells and then return the remaining blood back to the patient. You have already","text_display":" that has stem cells and then return the remaining blood back to the patient. You have already","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[733,516],[733,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":489,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d889f462368442478eefe3fb899b5697","type":"text","conversion_output":true,"text":"received this part of therapy.","text_display":" received this part of therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,604],[1878,604],[1878,649],[245,649]],"region":{"top_left_x":244,"top_left_y":603,"width":1634,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"feeea8256b6a4754875b3e061a26f8bf","type":"text","conversion_output":true,"text":"During the Consolidation phase of treatment extremely high doses of chemotherapy are given to","text_display":"\n\nDuring the Consolidation phase of treatment extremely high doses of chemotherapy are given to","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,647],[1876,647],[1876,694],[245,694]],"region":{"top_left_x":244,"top_left_y":646,"width":1632,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e78c24810a1545a4b23ac3e3faff537d","type":"text","conversion_output":true,"text":"better kill any remaining neuroblastoma cells. It is standard therapy to give one cycle of this","text_display":" better kill any remaining neuroblastoma cells. It is standard therapy to give one cycle of this","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1878,692],[1878,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1634,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccb3f16e269a49639607ebdca6bed5f4","type":"text","conversion_output":true,"text":"extremely high dose chemotherapy. The high doses of chemotherapy destroy healthy bone","text_display":" extremely high dose chemotherapy. The high doses of chemotherapy destroy healthy bone","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[245,735],[1880,735],[1880,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c02154ec2f8b4441b8d61f35a7da5b25","type":"text","conversion_output":true,"text":"marrow. Bone marrow is the soft tissue in the hollow of flat bones of the body that produces new","text_display":" marrow. Bone marrow is the soft tissue in the hollow of flat bones of the body that produces new","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1880,778],[1880,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1636,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fea3619f7d34b8e840cc73053017577","type":"text","conversion_output":true,"text":"blood cells. The peripheral blood stem cells that were stored during the Induction phase of","text_display":" blood cells. The peripheral blood stem cells that were stored during the Induction phase of","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1880,821],[1880,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1636,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5a10441a2c54b7ea59b89efe4933c31","type":"text","conversion_output":true,"text":"treatment are given back to the patient after the high dose Consolidation chemotherapy. These","text_display":" treatment are given back to the patient after the high dose Consolidation chemotherapy. These","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1876,868],[1876,909],[245,909]],"region":{"top_left_x":244,"top_left_y":867,"width":1632,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c21642a31a2406d8a8dbd424847c1b9","type":"text","conversion_output":true,"text":"stems cells allow the bone marrow to return to normal so that new blood cells can be made.","text_display":" stems cells allow the bone marrow to return to normal so that new blood cells can be made.","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1878,911],[1878,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1634,"height":47},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13d97aa0b0d64054b061b0413f1af10d","type":"text","conversion_output":true,"text":"This type of therapy is called a Hematopoietic Stem Cell Transplant. Once the patient has","text_display":" This type of therapy is called a Hematopoietic Stem Cell Transplant. Once the patient has","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1880,954],[1880,999],[245,999]],"region":{"top_left_x":244,"top_left_y":953,"width":1636,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"492223ba78304c5c8f33ff2460dc0b49","type":"text","conversion_output":true,"text":"healed from the effects of high doses of chemotherapy, radiation therapy is given to the first","text_display":" healed from the effects of high doses of chemotherapy, radiation therapy is given to the first","confidence":0.9985356330871582,"confidence_rate":0.9999851976838389},{"cnt":[[245,997],[1880,997],[1880,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1636,"height":49},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c882c678b4549479bbf4cc0808cb575","type":"text","conversion_output":true,"text":"place the tumor was found and to any additional places where the tumor was found after","text_display":" place the tumor was found and to any additional places where the tumor was found after","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[554,1042],[554,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":311,"height":49},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a72af1bfe48544daa182a431e5b1adce","type":"text","conversion_output":true,"text":"Induction therapy.","text_display":" Induction therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1130],[1880,1130],[1880,1175],[245,1175]],"region":{"top_left_x":244,"top_left_y":1130,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ddc4782bec3441958600b1c922f6c826","type":"text","conversion_output":true,"text":"During the third phase of therapy, Maintenance, an oral drug, called cis-retinoic acid (Accutane)","text_display":"\n\nDuring the third phase of therapy, Maintenance, an oral drug, called cis-retinoic acid (Accutane)","confidence":1,"confidence_rate":1},{"cnt":[[245,1173],[393,1173],[393,1222],[245,1222]],"region":{"top_left_x":244,"top_left_y":1173,"width":150,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b342d8c84ce14e6c92f46ee0fce52dc5","type":"text","conversion_output":true,"text":"is given.","text_display":" is given.","confidence":1,"confidence_rate":1},{"cnt":[[240,1257],[904,1255],[905,1302],[241,1304]],"region":{"top_left_x":240,"top_left_y":1254,"width":665,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa893bc7e6dc4639880a2732a620d324","type":"section_header","conversion_output":false,"children_ids":["2e09fcdf97b440a489d9bfbea4e6faa4"],"text":"","text_display":""},{"cnt":[[245,1259],[900,1259],[900,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1258,"width":657,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e09fcdf97b440a489d9bfbea4e6faa4","type":"text","conversion_output":true,"parent_id":"aa893bc7e6dc4639880a2732a620d324","text":"WHY IS THIS STUDY BEING DONE?","text_display":"\n\n\\section*{WHY IS THIS STUDY BEING DONE?}","confidence":1,"confidence_rate":1},{"cnt":[[245,1302],[1880,1302],[1880,1347],[245,1347]],"region":{"top_left_x":244,"top_left_y":1301,"width":1636,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b03c94c075e45ecb6b612a7fcbe0f0c","type":"text","conversion_output":true,"text":"The main goal of this research study is to find out if using 2 cycles of high dose","text_display":"\n\nThe main goal of this research study is to find out if using 2 cycles of high dose","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[245,1345],[1878,1345],[1878,1388],[245,1388]],"region":{"top_left_x":244,"top_left_y":1344,"width":1634,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b075168c0ff4aaf901b422fe42ad9eb","type":"text","conversion_output":true,"text":"Consolidation chemotherapy, instead of 1 cycle, will decrease the chance that the","text_display":" Consolidation chemotherapy, instead of 1 cycle, will decrease the chance that the","confidence":0.9990234375,"confidence_rate":0.9999890220866866},{"cnt":[[245,1384],[1878,1384],[1878,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1383,"width":1634,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abe0ec306b394ac19bde963c4f719450","type":"text","conversion_output":true,"text":"neuroblastoma will grow back after therapy. 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The transplant will begin with treatment with very high doses","text_display":" hematopoietic stem cell transplant. The transplant will begin with treatment with very high doses","confidence":1,"confidence_rate":1},{"cnt":[[247,1005],[1876,1005],[1876,1051],[247,1051]],"region":{"top_left_x":247,"top_left_y":1005,"width":1629,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b70051d83dc4a79a4b9fa612da59a1a","type":"text","conversion_output":true,"text":"of the chemotherapy drugs carboplatin, etoposide and melphalan. Etoposide and carboplatin","text_display":" of the chemotherapy drugs carboplatin, etoposide and melphalan. Etoposide and carboplatin","confidence":1,"confidence_rate":1},{"cnt":[[245,1051],[1876,1051],[1876,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1050,"width":1632,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b9803fb191049e3baff24d91fe394cb","type":"text","conversion_output":true,"text":"are given as a continuous infusion for 4 consecutive days. The drug melphalan is given as a","text_display":" are given as a continuous infusion for 4 consecutive days. The drug melphalan is given as a","confidence":1,"confidence_rate":1},{"cnt":[[245,1096],[1876,1096],[1876,1139],[245,1139]],"region":{"top_left_x":244,"top_left_y":1095,"width":1632,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1aec3377fb7d42cdb5b24693695afc53","type":"text","conversion_output":true,"text":"daily dose for 3 days. After the high dose chemotherapy treatment, your stored stem cells will","text_display":" daily dose for 3 days. After the high dose chemotherapy treatment, your stored stem cells will","confidence":1,"confidence_rate":1},{"cnt":[[245,1139],[1876,1139],[1876,1184],[245,1184]],"region":{"top_left_x":244,"top_left_y":1138,"width":1632,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28fa22a3573649a9ae019c0d25d7a461","type":"text","conversion_output":true,"text":"be given IV (through the central line). These stem cells were collected from you during the","text_display":" be given IV (through the central line). These stem cells were collected from you during the","confidence":1,"confidence_rate":1},{"cnt":[[245,1182],[1876,1182],[1876,1227],[245,1227]],"region":{"top_left_x":244,"top_left_y":1181,"width":1632,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bffe0c3a29c74b91bfe6eaa5a9849ec6","type":"text","conversion_output":true,"text":"induction phase of therapy and frozen. This is called a Hematopoietic Stem Cell Transplant.","text_display":" induction phase of therapy and frozen. This is called a Hematopoietic Stem Cell Transplant.","confidence":1,"confidence_rate":1},{"cnt":[[245,1227],[1876,1227],[1876,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1226,"width":1632,"height":49},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"103f79afb59b43a387cc305cb3d03015","type":"text","conversion_output":true,"text":"You will be given filgrastim (GCSF) starting on the same day you receive your stem cells and","text_display":" You will be given filgrastim (GCSF) starting on the same day you receive your stem cells and","confidence":1,"confidence_rate":1},{"cnt":[[245,1272],[1833,1272],[1833,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1271,"width":1589,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f3d2259341f4467bd90066dd3df6216","type":"text","conversion_output":true,"text":"continuing until your white blood cells have returned to a safe number, usually about 2 weeks.","text_display":" continuing until your white blood cells have returned to a safe number, usually about 2 weeks.","confidence":1,"confidence_rate":1},{"cnt":[[226,1358],[1723,1358],[1723,1639],[226,1639]],"region":{"top_left_x":225,"top_left_y":1357,"width":1499,"height":283},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"273befac4cfb4f338963ed3d2af10c5e","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|}\n\\hline Drug & How the drug will be given & Days \\\\\n\\hline Carboplatin & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Etoposide & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Melphalan & IV over 15-30 minutes & \\(-7,-6,-5\\) \\\\\n\\hline Blood Stem Cells & IV & 0 \\\\\n\\hline Filgrastim (GCSF) & SUBQ (or) IV & \\(0-14\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Drug & How the drug will be given & Days \\\\\n\\hline Carboplatin & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Etoposide & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Melphalan & IV over 15-30 minutes & \\(-7,-6,-5\\) \\\\\n\\hline Blood Stem Cells & IV & 0 \\\\\n\\hline Filgrastim (GCSF) & SUBQ (or) IV & \\(0-14\\) \\\\\n\\hline\n\\end{tabular}","confidence":0.905455284519121,"confidence_rate":0.9997053330816807},{"cnt":[[245,1684],[1257,1684],[1257,1734],[245,1734]],"region":{"top_left_x":244,"top_left_y":1684,"width":1013,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f720a713dcb8489b834c3def474e9dd5","type":"section_header","conversion_output":false,"children_ids":["cb6c0a2a858f4811a7bb95ef056c5027"],"text":"","text_display":""},{"cnt":[[249,1689],[1253,1689],[1253,1729],[249,1729]],"region":{"top_left_x":249,"top_left_y":1688,"width":1004,"height":42},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb6c0a2a858f4811a7bb95ef056c5027","type":"text","conversion_output":true,"parent_id":"f720a713dcb8489b834c3def474e9dd5","text":"Treatment for participants who are on treatment plan B","text_display":"\n\n\\section*{Treatment for participants who are on treatment plan B}","confidence":1,"confidence_rate":1},{"cnt":[[245,1775],[1878,1775],[1878,1820],[245,1820]],"region":{"top_left_x":244,"top_left_y":1774,"width":1634,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d5a43113e4746c88afaa46ad03652e7","type":"text","conversion_output":true,"text":"After completion of induction therapy, you will begin the first of the two cycles of very high dose","text_display":"\n\nAfter completion of induction therapy, you will begin the first of the two cycles of very high dose","confidence":1,"confidence_rate":1},{"cnt":[[245,1818],[1876,1818],[1876,1863],[245,1863]],"region":{"top_left_x":244,"top_left_y":1817,"width":1632,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0143682e82d343abba2b22f76881cc3b","type":"text","conversion_output":true,"text":"chemotherapy and hematopoietic stem cell transplant. The first transplant will begin with","text_display":" chemotherapy and hematopoietic stem cell transplant. The first transplant will begin with","confidence":1,"confidence_rate":1},{"cnt":[[245,1861],[1876,1861],[1876,1906],[245,1906]],"region":{"top_left_x":244,"top_left_y":1860,"width":1632,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17a47ffd255d44f8a5b12360f2d8cd1f","type":"text","conversion_output":true,"text":"treatment with very high doses of the chemotherapy drugs thiotepa and cyclophosphamide","text_display":" treatment with very high doses of the chemotherapy drugs thiotepa and cyclophosphamide","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1876,1904],[1876,1951],[245,1951]],"region":{"top_left_x":244,"top_left_y":1903,"width":1632,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cc59211b81c472ab8ccf5a78ebb183a","type":"text","conversion_output":true,"text":"given IV over 6 total days. After the high dose chemotherapy treatment, some of your stored","text_display":" given IV over 6 total days. After the high dose chemotherapy treatment, some of your stored","confidence":1,"confidence_rate":1},{"cnt":[[245,1949],[1876,1949],[1876,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1948,"width":1632,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"533b46a7c5124afcaf7feff5a34e76af","type":"text","conversion_output":true,"text":"stem cells will be given IV (through the central line). These stem cells were previously collected","text_display":" stem cells will be given IV (through the central line). These stem cells were previously collected","confidence":1,"confidence_rate":1},{"cnt":[[245,1994],[1878,1994],[1878,2039],[245,2039]],"region":{"top_left_x":244,"top_left_y":1993,"width":1634,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b06bab11efa4a57807a87c8b947989a","type":"text","conversion_output":true,"text":"from you during the induction phase and frozen. You will be given filgrastim (GCSF) starting on","text_display":" from you during the induction phase and frozen. You will be given filgrastim (GCSF) starting on","confidence":1,"confidence_rate":1},{"cnt":[[245,2037],[1880,2037],[1880,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2036,"width":1636,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64bb2b48349b47c9b6c117dc24fe582a","type":"text","conversion_output":true,"text":"the same day you get your stem cells and you will continue to get filgrastim (GCSF) until your","text_display":" the same day you get your stem cells and you will continue to get filgrastim (GCSF) until your","confidence":1,"confidence_rate":1},{"cnt":[[245,2082],[1485,2082],[1485,2125],[245,2125]],"region":{"top_left_x":244,"top_left_y":2081,"width":1241,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"320341b2519741728acf25a659c74c8f","type":"text","conversion_output":true,"text":"white blood cells have returned to a safe number, usually about 2 weeks.","text_display":" white blood cells have returned to a safe number, usually about 2 weeks.","confidence":1,"confidence_rate":1},{"cnt":[[226,2161],[1723,2161],[1723,2447],[226,2447]],"region":{"top_left_x":225,"top_left_y":2161,"width":1499,"height":287},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb1ee1409dcd4d2fbc276faedd4557dc","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|}\n\\hline Drug & How the drug will be given & Days \\\\\n\\hline Thiotepa & IV over 2 hours & \\(-7,-6,-5\\) \\\\\n\\hline Cyclophosphamide & IV over 1 hour & \\(-5,-4,-3,-2\\) \\\\\n\\hline Mesna & IV over 15 minutes & \\(-5,-4,-3,-2\\) \\\\\n\\hline Blood Stem Cells & IV & 0 \\\\\n\\hline GCSF & SUBQ (or) IV & \\(0-14\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Drug & How the drug will be given & Days \\\\\n\\hline Thiotepa & IV over 2 hours & \\(-7,-6,-5\\) \\\\\n\\hline Cyclophosphamide & IV over 1 hour & \\(-5,-4,-3,-2\\) \\\\\n\\hline Mesna & IV over 15 minutes & \\(-5,-4,-3,-2\\) \\\\\n\\hline Blood Stem Cells & IV & 0 \\\\\n\\hline GCSF & SUBQ (or) IV & \\(0-14\\) \\\\\n\\hline\n\\end{tabular}","confidence":0.336383196968432,"confidence_rate":0.9966737269080644},{"cnt":[[1732,2587],[1876,2587],[1876,2628],[1732,2628]],"region":{"top_left_x":1731,"top_left_y":2586,"width":145,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3175d3de47b54a8b9fea8bb3ad2d640f","type":"page_info","conversion_output":false,"text":"Page 156","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-157","page":157,"lines":[{"cnt":[[249,125],[612,125],[612,187],[249,187]],"region":{"top_left_x":249,"top_left_y":124,"width":364,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"078f18bb04cf486e8a1700202c9da3f9","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2459c74ad19745dcaa27ab76e41753f1","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,200],[651,200],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":199,"width":321,"height":31},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3bee9bea601846899066b77faea75ac6","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[249,258],[1876,258],[1876,301],[249,301]],"region":{"top_left_x":249,"top_left_y":257,"width":1627,"height":44},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e28547e128a45e896e9b127e8628ed9","type":"text","conversion_output":true,"text":"Between 6-10 weeks from the start of the first treatment a second cycle of very high dose","text_display":"\n\nBetween 6-10 weeks from the start of the first treatment a second cycle of very high dose","confidence":1,"confidence_rate":1},{"cnt":[[247,301],[1876,301],[1876,346],[247,346]],"region":{"top_left_x":247,"top_left_y":300,"width":1629,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6524e4c2d9194558ab9c746439bd13ff","type":"text","conversion_output":true,"text":"treatment is given. The treatment includes the drugs etoposide and carboplatin, which are given","text_display":" treatment is given. The treatment includes the drugs etoposide and carboplatin, which are given","confidence":1,"confidence_rate":1},{"cnt":[[247,346],[1878,346],[1878,389],[247,389]],"region":{"top_left_x":247,"top_left_y":345,"width":1631,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e6cf39f567440498c918b7d1b9276fd","type":"text","conversion_output":true,"text":"as a continuous infusion for 4 consecutive days. The drug melphalan is also given as a daily","text_display":" as a continuous infusion for 4 consecutive days. The drug melphalan is also given as a daily","confidence":0.9990236759185791,"confidence_rate":0.9999902320377446},{"cnt":[[247,387],[1876,387],[1876,432],[247,432]],"region":{"top_left_x":247,"top_left_y":386,"width":1629,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd0ee899ab964193adc6760a36b111a7","type":"text","conversion_output":true,"text":"dose for 3 days during this treatment. After this second high dose chemotherapy treatment,","text_display":" dose for 3 days during this treatment. After this second high dose chemotherapy treatment,","confidence":1,"confidence_rate":1},{"cnt":[[247,432],[1876,432],[1876,475],[247,475]],"region":{"top_left_x":247,"top_left_y":431,"width":1629,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a56e6871416462faeef827e11979294","type":"text","conversion_output":true,"text":"some of your remaining stored stem cells will be given back to you. You will be given the same","text_display":" some of your remaining stored stem cells will be given back to you. You will be given the same","confidence":1,"confidence_rate":1},{"cnt":[[247,477],[1878,477],[1878,520],[247,520]],"region":{"top_left_x":247,"top_left_y":476,"width":1631,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7289e5b80004ab9a2df889117b07d17","type":"text","conversion_output":true,"text":"care as the first transplant. You will be given filgrastim (GCSF) starting on the same day you get","text_display":" care as the first transplant. You will be given filgrastim (GCSF) starting on the same day you get","confidence":1,"confidence_rate":1},{"cnt":[[247,520],[1876,520],[1876,565],[247,565]],"region":{"top_left_x":247,"top_left_y":519,"width":1629,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a9bc87d1c614acea17e2bd561b00ef7","type":"text","conversion_output":true,"text":"your stem cells and you will continue to get filgrastim (GCSF) until your white blood cells have","text_display":" your stem cells and you will continue to get filgrastim (GCSF) until your white blood cells have","confidence":1,"confidence_rate":1},{"cnt":[[247,563],[1098,563],[1098,608],[247,608]],"region":{"top_left_x":247,"top_left_y":562,"width":851,"height":47},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"694fd52bd27f4e12b0d97740a876f248","type":"text","conversion_output":true,"text":"returned to a safe number, usually about 2 weeks.","text_display":" returned to a safe number, usually about 2 weeks.","confidence":1,"confidence_rate":1},{"cnt":[[226,690],[1691,690],[1691,973],[226,973]],"region":{"top_left_x":225,"top_left_y":689,"width":1466,"height":285},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01134bdb28664c9aa063908621d8a59e","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|}\n\\hline Drug & How the drug will be given & Days \\\\\n\\hline Carboplatin & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Etoposide & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Melphalan & IV over \\(15-30\\) minutes & \\(-7,-6,-5\\) \\\\\n\\hline Blood Stem Cells & IV & 0 \\\\\n\\hline Filgrastim (GCSF) & SUBQ (or) IV & \\(0-14\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Drug & How the drug will be given & Days \\\\\n\\hline Carboplatin & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Etoposide & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Melphalan & IV over \\(15-30\\) minutes & \\(-7,-6,-5\\) \\\\\n\\hline Blood Stem Cells & IV & 0 \\\\\n\\hline Filgrastim (GCSF) & SUBQ (or) IV & \\(0-14\\) \\\\\n\\hline\n\\end{tabular}","confidence":0.9747804967846605,"confidence_rate":0.9999261791271112},{"cnt":[[245,1057],[591,1057],[591,1106],[245,1106]],"region":{"top_left_x":244,"top_left_y":1057,"width":347,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9bb03408c5e406dac5bda85d3c22343","type":"section_header","conversion_output":false,"children_ids":["307722fb954648d48be61fe3bc70b641"],"text":"","text_display":""},{"cnt":[[247,1061],[587,1061],[587,1102],[247,1102]],"region":{"top_left_x":247,"top_left_y":1061,"width":340,"height":42},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"307722fb954648d48be61fe3bc70b641","type":"text","conversion_output":true,"parent_id":"c9bb03408c5e406dac5bda85d3c22343","text":"Radiation Therapy","text_display":"\n\n\\section*{Radiation Therapy}","confidence":0.998046875,"confidence_rate":0.9999111387285874},{"cnt":[[245,1147],[1876,1147],[1876,1192],[245,1192]],"region":{"top_left_x":244,"top_left_y":1147,"width":1632,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a70ff5ecc8274131a77a06b3150cb1cb","type":"text","conversion_output":true,"text":"It is standard to give radiation treatment to the area of the main tumor and to areas that still","text_display":"\n\nIt is standard to give radiation treatment to the area of the main tumor and to areas that still","confidence":1,"confidence_rate":1},{"cnt":[[245,1190],[1880,1190],[1880,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1190,"width":1636,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"642c96a85f4f4fdb94f033c3604a6419","type":"text","conversion_output":true,"text":"showed signs of active disease at the end of Induction phase of treatment. Radiation therapy","text_display":" showed signs of active disease at the end of Induction phase of treatment. Radiation therapy","confidence":1,"confidence_rate":1},{"cnt":[[245,1233],[1880,1233],[1880,1278],[245,1278]],"region":{"top_left_x":244,"top_left_y":1233,"width":1636,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc607235394d409fb6d603bc9b364a3f","type":"text","conversion_output":true,"text":"will begin after you have gotten better from the immediate side effects of the high doses of","text_display":" will begin after you have gotten better from the immediate side effects of the high doses of","confidence":1,"confidence_rate":1},{"cnt":[[245,1278],[1878,1278],[1878,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1278,"width":1634,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a79c149b575402d95c524dec8681fb5","type":"text","conversion_output":true,"text":"chemotherapy. If you are randomized to arm B (2 cycles of consolidation chemotherapy) you","text_display":" chemotherapy. If you are randomized to arm B (2 cycles of consolidation chemotherapy) you","confidence":0.9985356330871582,"confidence_rate":0.9999844103327336},{"cnt":[[245,1319],[1880,1319],[1880,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1319,"width":1636,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e983cdb967f40bfa1b6fd2b81f43ebd","type":"text","conversion_output":true,"text":"will get radiation therapy after you have recovered from the \\(2^{\\text {nd }}\\) transplant. Radiation therapy","text_display":" will get radiation therapy after you have recovered from the \\(2^{\\text {nd }}\\) transplant. Radiation therapy","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,1366],[1878,1366],[1878,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1366,"width":1634,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82139ee5b64b482fb43458adb2035e65","type":"text","conversion_output":true,"text":"usually starts about a month after the transplant. The radiation therapy doctors will discuss this","text_display":" usually starts about a month after the transplant. The radiation therapy doctors will discuss this","confidence":1,"confidence_rate":1},{"cnt":[[245,1409],[1880,1409],[1880,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1409,"width":1636,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c672d85fe9443c58915b1d08497a8ce","type":"text","conversion_output":true,"text":"with you in more detail. The radiation is given in one short session each day, for a period of","text_display":" with you in more detail. The radiation is given in one short session each day, for a period of","confidence":1,"confidence_rate":1},{"cnt":[[245,1452],[1878,1452],[1878,1500],[245,1500]],"region":{"top_left_x":244,"top_left_y":1452,"width":1634,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf5ea2a878a04c54bc24cc7677d3474b","type":"text","conversion_output":true,"text":"about 3-4 weeks. Radiation to the stomach may cause nausea and vomiting, and often causes","text_display":" about 3-4 weeks. 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Other risks are discussed below.","text_display":" transfusions (give you blood). Other risks are discussed below.","confidence":0.9990234375,"confidence_rate":0.9999856318731074},{"cnt":[[245,1629],[1876,1629],[1876,1676],[245,1676]],"region":{"top_left_x":244,"top_left_y":1628,"width":1632,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82f1bee65fc041f38a0acbf0637aa1b8","type":"text","conversion_output":true,"text":"You will get a higher dose of radiation treatment if x-ray tests performed at the end of Induction","text_display":"\n\nYou will get a higher dose of radiation treatment if x-ray tests performed at the end of Induction","confidence":0.9458270072937012,"confidence_rate":0.9994594122459031},{"cnt":[[245,1674],[1878,1674],[1878,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1673,"width":1634,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb0c9b8a2e1b41f195fe3708961d4566","type":"text","conversion_output":true,"text":"therapy still show tumor (a lump). The higher dose of radiation will only be given to the area","text_display":" therapy still show tumor (a lump). The higher dose of radiation will only be given to the area","confidence":1,"confidence_rate":1},{"cnt":[[245,1719],[1880,1719],[1880,1764],[245,1764]],"region":{"top_left_x":244,"top_left_y":1718,"width":1636,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb66771e61a94732aeba97fca1f98502","type":"text","conversion_output":true,"text":"where tumor is present. This higher dose of radiation is experimental. We are studying whether","text_display":" where tumor is present. This higher dose of radiation is experimental. We are studying whether","confidence":1,"confidence_rate":1},{"cnt":[[245,1762],[1482,1762],[1482,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1761,"width":1239,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eccc6c250cbe419f9ab87c58270a9de5","type":"text","conversion_output":true,"text":"this higher dose of radiation will decrease the risk of tumor growing back.","text_display":" this higher dose of radiation will decrease the risk of tumor growing back.","confidence":1,"confidence_rate":1},{"cnt":[[243,1848],[930,1848],[930,1893],[243,1893]],"region":{"top_left_x":242,"top_left_y":1847,"width":689,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e8650be98d94f2eac9fdaa2a54ad041","type":"section_header","conversion_output":false,"children_ids":["bf60bced711a496781355ff63dea2721"],"text":"","text_display":""},{"cnt":[[245,1850],[926,1850],[926,1888],[245,1888]],"region":{"top_left_x":244,"top_left_y":1849,"width":682,"height":40},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf60bced711a496781355ff63dea2721","type":"text","conversion_output":true,"parent_id":"8e8650be98d94f2eac9fdaa2a54ad041","text":"MAINTENANCE PHASE OF THERAPY","text_display":"\n\n\\section*{MAINTENANCE PHASE OF THERAPY}","confidence":1,"confidence_rate":1},{"cnt":[[245,1893],[1878,1893],[1878,1938],[245,1938]],"region":{"top_left_x":244,"top_left_y":1892,"width":1634,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e081f06f834849249551004ba5097328","type":"text","conversion_output":true,"text":"Maintenance therapy will begin after you have recovered from effects of radiation therapy. 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It is strongly encouraged that you speak with your physician about receiving","text_display":" clinical trial. It is strongly encouraged that you speak with your physician about receiving","confidence":1,"confidence_rate":1},{"cnt":[[245,2157],[1880,2157],[1880,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2157,"width":1636,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8623accf2f341b8966699599baf4743","type":"text","conversion_output":true,"text":"chimeric 14.18 therapy. If you are not able to get ch14.18 therapy or choose not to get it, then","text_display":" chimeric 14.18 therapy. If you are not able to get ch14.18 therapy or choose not to get it, then","confidence":1,"confidence_rate":1},{"cnt":[[245,2200],[1878,2200],[1878,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2200,"width":1634,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6a6fbe310644025b591cb5ccbea4d17","type":"text","conversion_output":true,"text":"you will get cis-Retinoic acid (Accutane) therapy alone. Cis-Retinoic acid is given by mouth,","text_display":" you will get cis-Retinoic acid (Accutane) therapy alone. Cis-Retinoic acid is given by mouth,","confidence":1,"confidence_rate":1},{"cnt":[[245,2243],[1878,2243],[1878,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2242,"width":1634,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e717ad54e3cb4704a44e095b049c2050","type":"text","conversion_output":true,"text":"twice daily for 2 weeks, followed by two weeks without the drug. 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for","confidence":1,"confidence_rate":1},{"cnt":[[309,294],[378,294],[378,339],[309,339]],"region":{"top_left_x":309,"top_left_y":294,"width":70,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e8e36e8656943af9aaab2013f30e21b","type":"text","conversion_output":true,"text":"you","text_display":" you","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1876,374],[1876,419],[245,419]],"region":{"top_left_x":244,"top_left_y":373,"width":1632,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63cdc553538945e1a0081d3918591925","type":"text","conversion_output":true,"text":"You can stop participating at any time. However, if you decide to stop participating in the study,","text_display":"\n\nYou can stop participating at any time. However, if you decide to stop participating in the study,","confidence":1,"confidence_rate":1},{"cnt":[[245,419],[1489,419],[1489,462],[245,462]],"region":{"top_left_x":244,"top_left_y":418,"width":1245,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70d1946af43f41c4a58c93853a9e6945","type":"text","conversion_output":true,"text":"we encourage you to talk to the study doctor and your regular doctor first.","text_display":" we encourage you to talk to the study doctor and your regular doctor first.","confidence":1,"confidence_rate":1},{"cnt":[[243,507],[988,507],[988,548],[243,548]],"region":{"top_left_x":242,"top_left_y":507,"width":747,"height":41},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f25d74c5f59842c49418ba7d932b1a70","type":"section_header","conversion_output":false,"children_ids":["02bd080ce7854b0c9966e5d60fcb4a91"],"text":"","text_display":""},{"cnt":[[245,509],[986,509],[986,544],[245,544]],"region":{"top_left_x":244,"top_left_y":509,"width":743,"height":35},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02bd080ce7854b0c9966e5d60fcb4a91","type":"text","conversion_output":true,"parent_id":"f25d74c5f59842c49418ba7d932b1a70","text":"WHAT ARE THE RISKS OF THE STUDY?","text_display":"\n\n\\section*{WHAT ARE THE RISKS OF THE STUDY?}","confidence":1,"confidence_rate":1},{"cnt":[[245,593],[552,593],[552,638],[245,638]],"region":{"top_left_x":244,"top_left_y":592,"width":309,"height":47},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0816812b460d4a3a9468f96d4b325cc7","type":"section_header","conversion_output":false,"children_ids":["b62b0e8feb454dda82a90b4e3d02c430"],"text":"","text_display":""},{"cnt":[[249,597],[548,597],[548,634],[249,634]],"region":{"top_left_x":249,"top_left_y":597,"width":299,"height":37},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b62b0e8feb454dda82a90b4e3d02c430","type":"text","conversion_output":true,"parent_id":"0816812b460d4a3a9468f96d4b325cc7","text":"Treatment Risks","text_display":"\n\n\\section*{Treatment Risks}","confidence":1,"confidence_rate":1},{"cnt":[[245,640],[1876,640],[1876,681],[245,681]],"region":{"top_left_x":244,"top_left_y":640,"width":1632,"height":42},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ee2a240e4934ebe94c89513c6e01681","type":"text","conversion_output":true,"text":"All people who have cancer treatment are at risk of having side effects. 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As a","text_display":"\n- Cyclophosphamide and melphalan will cause damage to the sexual glands. As a","confidence":1,"confidence_rate":1},{"cnt":[[434,610],[1880,610],[1880,655],[434,655]],"region":{"top_left_x":433,"top_left_y":610,"width":1447,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c44057f3787d46088a2693e7ad1ab1db","type":"text","conversion_output":true,"text":"result, if you are a boy, you will almost certainly not be able to have biologically","text_display":" result, if you are a boy, you will almost certainly not be able to have biologically","confidence":1,"confidence_rate":1},{"cnt":[[434,657],[1880,657],[1880,698],[434,698]],"region":{"top_left_x":433,"top_left_y":657,"width":1447,"height":42},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"113af8ba66a74404b5a7061489584365","type":"text","conversion_output":true,"text":"related children, and, if you are girl, you are likely to need hormones or other","text_display":" related children, and, if you are girl, you are likely to need hormones or other","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[434,700],[947,700],[947,737],[434,737]],"region":{"top_left_x":433,"top_left_y":700,"width":515,"height":37},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9636dcf693c344d79c2d600b6e00cc61","type":"text","conversion_output":true,"text":"interventions to have children.","text_display":" interventions to have children.","confidence":1,"confidence_rate":1},{"cnt":[[245,743],[578,743],[578,788],[245,788]],"region":{"top_left_x":244,"top_left_y":743,"width":334,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be2b55ff0c7b4b79b8981711023b1e97","type":"text","conversion_output":true,"text":"Reproductive risks:","text_display":"\nReproductive risks:","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[1876,786],[1876,831],[245,831]],"region":{"top_left_x":244,"top_left_y":786,"width":1632,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"994b55fe42f84431955312426ba1f03e","type":"text","conversion_output":true,"text":"It is unknown what effect(s) these treatments may have on an unborn child. As the drugs","text_display":"\nIt is unknown what effect(s) these treatments may have on an unborn child. As the drugs","confidence":1,"confidence_rate":1},{"cnt":[[245,834],[1876,834],[1876,874],[245,874]],"region":{"top_left_x":244,"top_left_y":833,"width":1632,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cef1f6d2a41047a2b27a73537dcdd39a","type":"text","conversion_output":true,"text":"and/or radiation therapy in this study can affect a developing fetus (unborn baby in the womb),","text_display":" and/or radiation therapy in this study can affect a developing fetus (unborn baby in the womb),","confidence":1,"confidence_rate":1},{"cnt":[[245,874],[1876,874],[1876,917],[245,917]],"region":{"top_left_x":244,"top_left_y":874,"width":1632,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ccdf43ed09d4434b393e4509efbc28a","type":"text","conversion_output":true,"text":"you should not become pregnant or father a baby while on this study. For this reason, if you","text_display":" you should not become pregnant or father a baby while on this study. For this reason, if you","confidence":1,"confidence_rate":1},{"cnt":[[245,920],[1878,920],[1878,965],[245,965]],"region":{"top_left_x":244,"top_left_y":919,"width":1634,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73261be6c5ca479c97048decd9f9196d","type":"text","conversion_output":true,"text":"are of child-bearing age, you will be asked to practice an effective method of birth control","text_display":" are of child-bearing age, you will be asked to practice an effective method of birth control","confidence":1,"confidence_rate":1},{"cnt":[[245,962],[1878,962],[1878,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":962,"width":1634,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc79b932004443509172a9ed64f07171","type":"text","conversion_output":true,"text":"while participating on this study. The use of Isotretinoin can cause birth defects to","text_display":" while participating on this study. The use of Isotretinoin can cause birth defects to","confidence":0.9341139793395996,"confidence_rate":0.9992429887372183},{"cnt":[[245,1005],[1876,1005],[1876,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1005,"width":1632,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b1e08bc1fe0416cb2787ef1f4220fc6","type":"text","conversion_output":true,"text":"unborn children if taken during pregnancy. Ask about counseling and more information","text_display":" unborn children if taken during pregnancy. Ask about counseling and more information","confidence":1,"confidence_rate":1},{"cnt":[[245,1051],[1876,1051],[1876,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1050,"width":1632,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e18bc99750bf48f0bb0914ab87f44f0e","type":"text","conversion_output":true,"text":"about preventing pregnancy. Having the chemotherapy described may cause infertility (being","text_display":" about preventing pregnancy. Having the chemotherapy described may cause infertility (being","confidence":1,"confidence_rate":1},{"cnt":[[245,1096],[1880,1096],[1880,1139],[245,1139]],"region":{"top_left_x":244,"top_left_y":1095,"width":1636,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19e8c66c0aaa45d5a74b32355f5a2e00","type":"text","conversion_output":true,"text":"less able to produce a viable egg or sperm) or sterility (being unable to produce a viable egg or","text_display":" less able to produce a viable egg or sperm) or sterility (being unable to produce a viable egg or","confidence":0.99853515625,"confidence_rate":0.9999856283612877},{"cnt":[[245,1139],[1575,1139],[1575,1184],[245,1184]],"region":{"top_left_x":244,"top_left_y":1138,"width":1331,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18ca87f8b85f4ce79bedb022c361d770","type":"text","conversion_output":true,"text":"sperm). We will talk to males who have reached puberty about sperm banking.","text_display":" sperm). 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You should not become pregnant or","text_display":"\n\nThe treatment on this study can affect an unborn child. You should not become pregnant or","confidence":1,"confidence_rate":1},{"cnt":[[245,1308],[1878,1308],[1878,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1308,"width":1634,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff76e369992f4b42819b048ec83b26d8","type":"text","conversion_output":true,"text":"breast feed your baby while being treated on this study. If you are sexually active and are at risk","text_display":" breast feed your baby while being treated on this study. If you are sexually active and are at risk","confidence":1,"confidence_rate":1},{"cnt":[[247,1349],[1876,1349],[1876,1394],[247,1394]],"region":{"top_left_x":247,"top_left_y":1349,"width":1629,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84afbfea10704f61b86e2c94667d89fd","type":"text","conversion_output":true,"text":"of getting pregnant, you and your male partner(s) must use an effective method to avoid","text_display":" of getting pregnant, you and your male partner(s) must use an effective method to avoid","confidence":1,"confidence_rate":1},{"cnt":[[247,1392],[1876,1392],[1876,1435],[247,1435]],"region":{"top_left_x":247,"top_left_y":1392,"width":1629,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80ca4060276443e0a03bce046f23af84","type":"text","conversion_output":true,"text":"pregnancy or you must not have sex. The study doctor will talk to you about acceptable","text_display":" pregnancy or you must not have sex. The study doctor will talk to you about acceptable","confidence":1,"confidence_rate":1},{"cnt":[[247,1433],[1876,1433],[1876,1476],[247,1476]],"region":{"top_left_x":247,"top_left_y":1433,"width":1629,"height":43},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65774787aec442528794ae5b3176de29","type":"text","conversion_output":true,"text":"methods to avoid pregnancy while you are being treated on this study. You will have to use the","text_display":" methods to avoid pregnancy while you are being treated on this study. 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You may need to continue this for a while, even after you finish","text_display":" are being treated on this study. You may need to continue this for a while, even after you finish","confidence":1,"confidence_rate":1},{"cnt":[[245,1558],[1876,1558],[1876,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1557,"width":1632,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4fd6bedec3664b168f73bcffe6f450f6","type":"text","conversion_output":true,"text":"the cancer treatment, so talk to your doctor about the length of time you need to avoid","text_display":" the cancer treatment, so talk to your doctor about the length of time you need to avoid","confidence":1,"confidence_rate":1},{"cnt":[[245,1598],[1876,1598],[1876,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1598,"width":1632,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82435f6241424406ac0f6e8110ea3cc6","type":"text","conversion_output":true,"text":"pregnancy or abstain. Natural family planning and the rhythm method will not be permissible","text_display":" pregnancy or abstain. Natural family planning and the rhythm method will not be permissible","confidence":1,"confidence_rate":1},{"cnt":[[245,1641],[1880,1641],[1880,1684],[245,1684]],"region":{"top_left_x":244,"top_left_y":1641,"width":1636,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37104ca67f884c04ba7daa6deadc1bc1","type":"text","conversion_output":true,"text":"means of avoiding pregnancy during study participation. If you have questions about this or","text_display":" means of avoiding pregnancy during study participation. If you have questions about this or","confidence":1,"confidence_rate":1},{"cnt":[[245,1680],[1878,1680],[1878,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1680,"width":1634,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82ae7d05bbd64335b14276dc850d4ba6","type":"text","conversion_output":true,"text":"want to change your method to avoid pregnancy during therapy, please ask your doctor. If you","text_display":" want to change your method to avoid pregnancy during therapy, please ask your doctor. 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You","text_display":"\n\nIf you are nursing a baby, the drugs used in this research could pass into the breast milk. You","confidence":1,"confidence_rate":1},{"cnt":[[247,1895],[1878,1895],[1878,1940],[247,1940]],"region":{"top_left_x":247,"top_left_y":1894,"width":1631,"height":47},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed8ff141d309463b8d3c5a3bc6e4fa4b","type":"text","conversion_output":true,"text":"should not nurse your baby for the whole time you are getting the study medicines. You may","text_display":" should not nurse your baby for the whole time you are getting the study medicines. 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If you have questions","text_display":"\npermissible means of avoiding pregnancy during study participation. If you have questions","confidence":1,"confidence_rate":1},{"cnt":[[245,294],[1880,294],[1880,337],[245,337]],"region":{"top_left_x":244,"top_left_y":294,"width":1636,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6a14dc7156a4a25a5e74b7a368f26cc","type":"text","conversion_output":true,"text":"about this or want to change your method to avoid pregnancy during therapy, please ask your","text_display":" about this or want to change your method to avoid pregnancy during therapy, please ask your","confidence":1,"confidence_rate":1},{"cnt":[[245,335],[1880,335],[1880,380],[245,380]],"region":{"top_left_x":244,"top_left_y":335,"width":1636,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08b4443d224e45c2a6e792317c9c6522","type":"text","conversion_output":true,"text":"doctor. 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For most patients, the area receiving the additional radiation dose","text_display":" Induction phase of treatment. For most patients, the area receiving the additional radiation dose","confidence":1,"confidence_rate":1},{"cnt":[[245,1160],[1878,1160],[1878,1205],[245,1205]],"region":{"top_left_x":244,"top_left_y":1160,"width":1634,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d3669fd493a4b24a7c428ca87edb059","type":"text","conversion_output":true,"text":"will be small. However, it is possible that the use of higher doses of radiation may be more","text_display":" will be small. However, it is possible that the use of higher doses of radiation may be more","confidence":1,"confidence_rate":1},{"cnt":[[245,1205],[1583,1205],[1583,1250],[245,1250]],"region":{"top_left_x":244,"top_left_y":1205,"width":1340,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6d51c737de1468caca6e8d097ed6905","type":"text","conversion_output":true,"text":"likely to cause the side effects of radiation that are described in Attachment \\#2.","text_display":" likely to cause the side effects of radiation that are described in Attachment \\#2.","confidence":1,"confidence_rate":1},{"cnt":[[247,1293],[1772,1293],[1772,1338],[247,1338]],"region":{"top_left_x":247,"top_left_y":1293,"width":1526,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7150e26ea0d240418b78555313a76e32","type":"text","conversion_output":true,"text":"Please see the attachment at the end of the consent (Attachment \\#2) for more information","text_display":"\n\nPlease see the attachment at the end of the consent (Attachment \\#2) for more information","confidence":1,"confidence_rate":1},{"cnt":[[245,1336],[1876,1336],[1876,1381],[245,1381]],"region":{"top_left_x":244,"top_left_y":1336,"width":1632,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cb535a319e24160a10e4877565e50c8","type":"text","conversion_output":true,"text":"regarding the risks associated with radiation therapy and Peripheral Blood Stem Cell Harvesting","text_display":" regarding the risks associated with radiation therapy and Peripheral Blood Stem Cell Harvesting","confidence":1,"confidence_rate":1},{"cnt":[[245,1379],[518,1379],[518,1424],[245,1424]],"region":{"top_left_x":244,"top_left_y":1379,"width":274,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aff8ab6bc4ba4717b86ccf26ffc5cc98","type":"text","conversion_output":true,"text":"and Reinfusion.","text_display":" and Reinfusion.","confidence":1,"confidence_rate":1},{"cnt":[[247,1470],[1278,1470],[1278,1515],[247,1515]],"region":{"top_left_x":247,"top_left_y":1469,"width":1032,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a13a9ddef8d14c89be2590d2cabe8d2a","type":"text","conversion_output":true,"text":"Information may also be found in the COG Family Handbook","text_display":"\n\nInformation may also be found in the COG Family Handbook","confidence":1,"confidence_rate":1},{"cnt":[[247,1555],[1592,1555],[1592,1601],[247,1601]],"region":{"top_left_x":247,"top_left_y":1555,"width":1345,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fce65fb4ba3e44cf832707aa5b6a6ab0","type":"text","conversion_output":true,"text":"For more information about risks and side effects, ask your child's study doctor.","text_display":"\nFor more information about risks and side effects, ask your child's study doctor.","confidence":1,"confidence_rate":1},{"cnt":[[247,1646],[1820,1646],[1820,1691],[247,1691]],"region":{"top_left_x":247,"top_left_y":1645,"width":1573,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9b39df8c0854f96856cdee8d3e5c4b1","type":"text","conversion_output":true,"text":"In addition to the risks described above, there may be unknown risks, or risks that we did not","text_display":"\nIn addition to the risks described above, there may be unknown risks, or risks that we did not","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1025,1689],[1025,1734],[245,1734]],"region":{"top_left_x":244,"top_left_y":1688,"width":781,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a007749519224d5287a5e64f995bda66","type":"text","conversion_output":true,"text":"anticipate, associated with being in this study.","text_display":" anticipate, associated with being in this study.","confidence":1,"confidence_rate":1},{"cnt":[[245,1775],[1863,1775],[1863,1824],[245,1824]],"region":{"top_left_x":244,"top_left_y":1774,"width":1619,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac6dad9ff46b40b39058eeb6e6f14a4f","type":"text","conversion_output":true,"text":"Your physician will be checking closely to see if any of these side effects are occurring. Routine","text_display":"\n\nYour physician will be checking closely to see if any of these side effects are occurring. Routine","confidence":1,"confidence_rate":1},{"cnt":[[245,1818],[1876,1818],[1876,1865],[245,1865]],"region":{"top_left_x":244,"top_left_y":1817,"width":1632,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa71f1c7c16d4a8f9a2ad6e6589181d1","type":"text","conversion_output":true,"text":"physical exams and laboratory tests will be done to monitor the effects of treatment. Side effects","text_display":" physical exams and laboratory tests will be done to monitor the effects of treatment. Side effects","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,1865],[1106,1865],[1106,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1864,"width":863,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0e052448e5c46e5a9430162de30cabd","type":"text","conversion_output":true,"text":"usually disappear after the treatment is completed.","text_display":" usually disappear after the treatment is completed.","confidence":1,"confidence_rate":1},{"cnt":[[245,1951],[1876,1951],[1876,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1950,"width":1632,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7eb39eba02340d395ceec4bba086134","type":"text","conversion_output":true,"text":"Treatment on this study may have risks we don't know about. We may stop this treatment if","text_display":"\n\nTreatment on this study may have risks we don't know about. We may stop this treatment if","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,1994],[1837,1994],[1837,2041],[245,2041]],"region":{"top_left_x":244,"top_left_y":1993,"width":1593,"height":49},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a08a9b7dd6624b10a90c7bb6a6ebefe8","type":"text","conversion_output":true,"text":"we learn of serious, unexpected risks. We will explain the effects of stopping, and we will offer","text_display":" we learn of serious, unexpected risks. We will explain the effects of stopping, and we will offer","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[539,2041],[539,2078],[245,2078]],"region":{"top_left_x":244,"top_left_y":2041,"width":296,"height":37},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb226dc6f07c488eb4534604ebb9d6f1","type":"text","conversion_output":true,"text":"other treatments.","text_display":" other treatments.","confidence":1,"confidence_rate":1},{"cnt":[[247,2127],[1519,2127],[1519,2170],[247,2170]],"region":{"top_left_x":247,"top_left_y":2126,"width":1272,"height":44},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d93c6937a3ec406380d56b22805cea3d","type":"figure_label","conversion_output":false,"text":"Risks and side effects related to the thiotepa include those which are:","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[226,2166],[1850,2166],[1850,2486],[226,2486]],"region":{"top_left_x":225,"top_left_y":2165,"width":1625,"height":321},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a61ad27ea6cb4dbb8c182f55679c41f8","type":"table","conversion_output":true,"selected_labels":["d93c6937a3ec406380d56b22805cea3d"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{1}{|c|}{ Likely } & \\multicolumn{1}{c|}{ Less Likely } & Rare But Serious \\\\\n\\hline - Nausea & - Pain at the injection site & - Severe allergic \\\\\n- Vomiting & - Dizziness & reaction which can \\\\\n- Loss of appetite & - Headache & be life threatening \\\\\n- A feeling of extreme & - Blurred vision & with shortness of \\\\\ntiredness or weakness & - Hives, skin rash & breath, low blood \\\\\n- Fewer white blood cells, & - Wheezing & pressure and a \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Risks and side effects related to the thiotepa include those which are:}\n\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{1}{|c|}{ Likely } & \\multicolumn{1}{c|}{ Less Likely } & Rare But Serious \\\\\n\\hline - Nausea & - Pain at the injection site & - Severe allergic \\\\\n- Vomiting & - Dizziness & reaction which can \\\\\n- Loss of appetite & - Headache & be life threatening \\\\\n- A feeling of extreme & - Blurred vision & with shortness of \\\\\ntiredness or weakness & - Hives, skin rash & breath, low blood \\\\\n- Fewer white blood cells, & - Wheezing & pressure and a 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Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[226,247],[1848,247],[1848,1530],[226,1530]],"region":{"top_left_x":225,"top_left_y":247,"width":1623,"height":1283},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bab4702a08024138a39d0694b4d93dfc","type":"table","conversion_output":true,"children_ids":["177e821a161647e68d24c3de29191959","107b6296cdb9420abf68608678572f07","ed3f7d427b6347ef8903f3895e77cb80","3447a2e2274240fbbbdaa2b3f8facf3f","1ce88ab3cdc94c998a6687b036034cd4","a433a55a2ba2472d9a53347ccc056855","4c0583bdd65944d3ac152a303778b6a3"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\begin{tabular}{l}\nred blood cells and platelets in the blood. \\\\\n○ A low number of red blood cells can make you feel tired and weak. \\\\\n- A low number of white blood cells can make it easier to get infections. \\\\\n- A low number of platelets causes you to bruise and bleed \\\\\n- Absence or decrease in the number of sperm which may be temporary or permanent which may decrease the ability to have children \\\\\n- Absence or decrease in monthly periods and could affect your ability to become pregnant \\\\\nWith High Doses used before marrow transplants: \\\\\n- Inflammation and/or sores in the mouth, throat and/or esophagus (the passage between the throat and stomach)\n\\end{tabular} & \\begin{tabular}{l}\n- Sudden high fever \\\\\n- Pain in the abdomen \\\\\n- Difficulty emptying the bladder \\\\\n- Feeling the urgency to urinate or pain on urination \\\\\n- Hair loss \\\\\n- Inflammation and reddening of the eye \\\\\n- Inflammation of the skin where the drug comes into contact with the skin \\\\\nWith High Doses used before marrow transplants: \\\\\n- Inappropriate behavior \\\\\n- Confusion \\\\\n- Drowsiness \\\\\n- Elevation in the blood of certain enzymes and/or bilirubin found in the liver \\\\\n- Bronze discoloration or darkening of the skin\n\\end{tabular} & \\begin{tabular}{l}\nrapid heart rate \\\\\n- Swelling and tightening of the throat which can cause difficulty with breathing \\\\\n- A new cancer or leukemia resulting from this treatment\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\begin{tabular}{l}\nred blood cells and platelets in the blood. \\\\\n○ A low number of red blood cells can make you feel tired and weak. \\\\\n- A low number of white blood cells can make it easier to get infections. \\\\\n- A low number of platelets causes you to bruise and bleed \\\\\n- Absence or decrease in the number of sperm which may be temporary or permanent which may decrease the ability to have children \\\\\n- Absence or decrease in monthly periods and could affect your ability to become pregnant \\\\\nWith High Doses used before marrow transplants: \\\\\n- Inflammation and/or sores in the mouth, throat and/or esophagus (the passage between the throat and stomach)\n\\end{tabular} & \\begin{tabular}{l}\n- Sudden high fever \\\\\n- Pain in the abdomen \\\\\n- Difficulty emptying the bladder \\\\\n- Feeling the urgency to urinate or pain on urination \\\\\n- Hair loss \\\\\n- Inflammation and reddening of the eye \\\\\n- Inflammation of the skin where the drug comes into contact with the skin \\\\\nWith High Doses used before marrow transplants: \\\\\n- Inappropriate behavior \\\\\n- Confusion \\\\\n- Drowsiness \\\\\n- Elevation in the blood of certain enzymes and/or bilirubin found in the liver \\\\\n- Bronze discoloration or darkening of the skin\n\\end{tabular} & \\begin{tabular}{l}\nrapid heart rate \\\\\n- Swelling and tightening of the throat which can cause difficulty with breathing \\\\\n- A new cancer or leukemia resulting from this treatment\n\\end{tabular} 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blood cells and platelets in the blood. \\\\\n○ A low number of red blood cells can make you feel tired and weak. \\\\\n- A low number of white blood cells can make it easier to get infections. \\\\\n- A low number of platelets causes you to bruise and bleed \\\\\n- Absence or decrease in the number of sperm which may be temporary or permanent which may decrease the ability to have children \\\\\n- Absence or decrease in monthly periods and could affect your ability to become pregnant \\\\\nWith High Doses used before marrow transplants: \\\\\n- Inflammation and/or sores in the mouth, throat and/or esophagus (the passage between the throat and stomach)\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nred blood cells and platelets in the blood. \\\\\n○ A low number of red blood cells can make you feel tired and weak. \\\\\n- A low number of white blood cells can make it easier to get infections. \\\\\n- A low number of platelets causes you to bruise and bleed \\\\\n- Absence or decrease in the number of sperm which may be temporary or permanent which may decrease the ability to have children \\\\\n- Absence or decrease in monthly periods and could affect your ability to become pregnant \\\\\nWith High Doses used before marrow transplants: \\\\\n- Inflammation and/or sores in the mouth, throat and/or esophagus (the passage between the throat and stomach)\n\\end{tabular}","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.4961421489715576,"confidence_rate":0.9980356148719274},{"cnt":[[307,256],[665,256],[665,292],[307,292]],"region":{"top_left_x":307,"top_left_y":255,"width":358,"height":38},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec096407a9cf4cbea731e79496dcfc91","type":"text","conversion_output":false,"parent_id":"1ce88ab3cdc94c998a6687b036034cd4","text":"red blood cells and","text_display":"red blood cells 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\"we\"","text_display":"\n\nWhen the word \"you\" appears in this consent form, it refers to you or your son or daughter; \"we\"","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1177],[831,1177],[831,1216],[245,1216]],"region":{"top_left_x":244,"top_left_y":1177,"width":588,"height":40},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"452a24313aeb43568a419a59fabca162","type":"text","conversion_output":true,"text":"means the doctors and other staff.","text_display":" means the doctors and other staff.","confidence":1,"confidence_rate":1},{"cnt":[[243,1259],[1422,1259],[1422,1304],[243,1304]],"region":{"top_left_x":242,"top_left_y":1258,"width":1181,"height":47},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7de47aee951648aba91e789005810f6e","type":"section_header","conversion_output":false,"children_ids":["22de93b1959542318ed188a310e9183a"],"text":"","text_display":""},{"cnt":[[245,1263],[1420,1263],[1420,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1263,"width":1177,"height":37},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22de93b1959542318ed188a310e9183a","type":"text","conversion_output":true,"parent_id":"7de47aee951648aba91e789005810f6e","text":"WHY ARE YOU BEING INVITED TO TAKE PART IN THIS STUDY?","text_display":"\n\n\\section*{WHY ARE YOU BEING INVITED TO TAKE PART IN THIS STUDY?}","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1850,1306],[1850,1351],[245,1351]],"region":{"top_left_x":244,"top_left_y":1306,"width":1606,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42b3809575e54b47a257690e95ae6275","type":"text","conversion_output":true,"text":"This is a clinical trial, a type of research study. Your study doctor will explain the clinical trial to","text_display":"\n\nThis is a clinical trial, a type of research study. Your study doctor will explain the clinical trial to","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[324,1354],[324,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1353,"width":81,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6aff222be2644458a4dbba3c9c2dc9b7","type":"text","conversion_output":true,"text":"you.","text_display":" you.","confidence":1,"confidence_rate":1},{"cnt":[[245,1435],[1876,1435],[1876,1482],[245,1482]],"region":{"top_left_x":244,"top_left_y":1435,"width":1632,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a84e7d4de5e2426c8a95afe2bb5c16e9","type":"text","conversion_output":true,"text":"The Children's Oncology Group (COG) is carrying out this study. COG is an international","text_display":"\n\nThe Children's Oncology Group (COG) is carrying out this study. COG is an international","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,1480],[1876,1480],[1876,1525],[245,1525]],"region":{"top_left_x":244,"top_left_y":1480,"width":1632,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bc520277a0e44f896585c806057cdd0","type":"text","conversion_output":true,"text":"research group that conducts clinical trials for children with cancer at more than 200 hospitals in","text_display":" research group that conducts clinical trials for children with cancer at more than 200 hospitals in","confidence":0.9941489668563008,"confidence_rate":0.9999451583496364},{"cnt":[[245,1525],[1876,1525],[1876,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1525,"width":1632,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c9a874b213c4ad6adbc5f678416a052","type":"text","conversion_output":true,"text":"the United States, Canada, Australia, New Zealand, the Netherlands, and Switzerland. It is","text_display":" the United States, Canada, Australia, New Zealand, the Netherlands, and Switzerland. It is","confidence":1,"confidence_rate":1},{"cnt":[[245,1568],[1729,1568],[1729,1613],[245,1613]],"region":{"top_left_x":244,"top_left_y":1568,"width":1486,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dbab75602964c2f8361d1c6e6b6865e","type":"text","conversion_output":true,"text":"common medical practice to treat children with cancer on research studies like this one.","text_display":" common medical practice to treat children with cancer on research studies like this one.","confidence":1,"confidence_rate":1},{"cnt":[[245,1656],[1876,1656],[1876,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1656,"width":1632,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6edce13ec23446aa905da145cf7a93a9","type":"text","conversion_output":true,"text":"You are being asked to take part in this study because you have high risk neuroblastoma and","text_display":"\n\nYou are being asked to take part in this study because you have high risk neuroblastoma and","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[1878,1702],[1878,1747],[245,1747]],"region":{"top_left_x":244,"top_left_y":1701,"width":1634,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37d3e3964fde45d183a18c3dca9c1e5c","type":"text","conversion_output":true,"text":"you have participated in Part 1 of this study. Neuroblastoma is a type of cancer. You have the","text_display":" you have participated in Part 1 of this study. Neuroblastoma is a type of cancer. You have the","confidence":1,"confidence_rate":1},{"cnt":[[245,1745],[1880,1745],[1880,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1744,"width":1636,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0a235a04c23448b838e967eeea3710e","type":"text","conversion_output":true,"text":"type of neuroblastoma that is called High Risk because your tumor has spread from where it","text_display":" type of neuroblastoma that is called High Risk because your tumor has spread from where it","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1274,1788],[1274,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1031,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e38be826129439f8a5481def4713f2d","type":"text","conversion_output":true,"text":"started from or because your type of tumor is harder to treat.","text_display":" started from or because your type of tumor is harder to treat.","confidence":1,"confidence_rate":1},{"cnt":[[245,1876],[1878,1876],[1878,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1875,"width":1634,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0a4aa460d49430192f609133dc18390","type":"text","conversion_output":true,"text":"It is common to enroll children and adolescents with cancer in a clinical trial that seeks to","text_display":"\n\nIt is common to enroll children and adolescents with cancer in a clinical trial that seeks to","confidence":1,"confidence_rate":1},{"cnt":[[245,1919],[1876,1919],[1876,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1918,"width":1632,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0e47f06c8364066a50c5e4a316ba2f4","type":"text","conversion_output":true,"text":"improve cancer treatment over time. Clinical trials include only people who choose to take part.","text_display":" improve cancer treatment over time. Clinical trials include only people who choose to take part.","confidence":1,"confidence_rate":1},{"cnt":[[245,1964],[1878,1964],[1878,2009],[245,2009]],"region":{"top_left_x":244,"top_left_y":1963,"width":1634,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93e26a237878407f98c2a9883b3e50a8","type":"text","conversion_output":true,"text":"You have a choice between a standard treatment for High Risk neuroblastoma and this clinical","text_display":" You have a choice between a standard treatment for High Risk neuroblastoma and this clinical","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,2007],[1880,2007],[1880,2054],[245,2054]],"region":{"top_left_x":244,"top_left_y":2006,"width":1636,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3159168e686848a2ac44792e2e9be09a","type":"text","conversion_output":true,"text":"trial. Please take your time to make your decision about taking part in this clinical trial. You may","text_display":" trial. Please take your time to make your decision about taking part in this clinical trial. You may","confidence":1,"confidence_rate":1},{"cnt":[[245,2052],[1878,2052],[1878,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2051,"width":1634,"height":49},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d10a16b22e984fc289aa9d46732c0777","type":"text","conversion_output":true,"text":"discuss your decision with your friends and family. You can also discuss it with your health care","text_display":" discuss your decision with your friends and family. You can also discuss it with your health care","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1880,2097],[1880,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2096,"width":1636,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b29e9c8db2fc450595ce81a18563f0b7","type":"text","conversion_output":true,"text":"team. We encourage you to include your child in the discussion and decision to the extent that","text_display":" team. We encourage you to include your child in the discussion and decision to the extent that","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[1880,2140],[1880,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2139,"width":1636,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"245970ce7d284bde85a805bdd987f077","type":"text","conversion_output":true,"text":"she or he is able to understand and take part. If you have any questions, you can ask your","text_display":" she or he is able to understand and take part. If you have any questions, you can ask your","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[831,2183],[831,2228],[245,2228]],"region":{"top_left_x":244,"top_left_y":2182,"width":588,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b35917f1dce74e04b1acef321d1c35b3","type":"text","conversion_output":true,"text":"study doctor for more explanation.","text_display":" study doctor for more explanation.","confidence":1,"confidence_rate":1},{"cnt":[[243,2264],[1626,2264],[1626,2310],[243,2310]],"region":{"top_left_x":242,"top_left_y":2264,"width":1385,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a370b8efe55a4bdd868573d509757628","type":"section_header","conversion_output":false,"children_ids":["72cddb9d7e224b2cb10d4585a74c3ec6"],"text":"","text_display":""},{"cnt":[[245,2264],[1622,2264],[1622,2305],[245,2305]],"region":{"top_left_x":244,"top_left_y":2264,"width":1379,"height":42},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72cddb9d7e224b2cb10d4585a74c3ec6","type":"text","conversion_output":true,"parent_id":"a370b8efe55a4bdd868573d509757628","text":"WHAT IS THE CURRENT STANDARD OF TREATMENT FOR THIS DISEASE?","text_display":"\n\n\\section*{WHAT IS THE CURRENT STANDARD OF TREATMENT FOR THIS DISEASE?}","confidence":1,"confidence_rate":1},{"cnt":[[245,2312],[1876,2312],[1876,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2311,"width":1632,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f3a88af130d474f8d5bad11487fbfc6","type":"text","conversion_output":true,"text":"The treatment for neuroblastoma includes 3 parts (phases) of therapy called Induction,","text_display":"\n\nThe treatment for neuroblastoma includes 3 parts (phases) of therapy called Induction,","confidence":1,"confidence_rate":1},{"cnt":[[245,2355],[1878,2355],[1878,2400],[245,2400]],"region":{"top_left_x":244,"top_left_y":2354,"width":1634,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35eed3bb790d4a3aa212127d66b23728","type":"text","conversion_output":true,"text":"Consolidation and Maintenance. During Induction therapy anti-cancer drugs (chemotherapy)","text_display":" Consolidation and Maintenance. During Induction therapy anti-cancer drugs (chemotherapy)","confidence":1,"confidence_rate":1},{"cnt":[[245,2398],[1876,2398],[1876,2443],[245,2443]],"region":{"top_left_x":244,"top_left_y":2397,"width":1632,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59b9047e3b094374b3dbc57e2ad079c2","type":"text","conversion_output":true,"text":"and surgery are used to kill and remove as much tumor as possible. Blood stem cells are","text_display":" and surgery are used to kill and remove as much tumor as possible. 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Blood stem cells are the cells","text_display":"\nand stored to be used during Consolidation phase of treatment. Blood stem cells are the cells","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1876,296],[1876,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1632,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0b2c7f75ba24b84a4f4c277bce34e85","type":"text","conversion_output":true,"text":"that create new blood cells, such as red blood cells, white blood cells, and platelets. Blood stem","text_display":" that create new blood cells, such as red blood cells, white blood cells, and platelets. 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You have already","text_display":" that has stem cells and then return the remaining blood back to the patient. You have already","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[733,425],[733,471],[245,471]],"region":{"top_left_x":244,"top_left_y":425,"width":489,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a96b5c502744a73b44b4f0525774888","type":"text","conversion_output":true,"text":"received this part of therapy.","text_display":" received this part of therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1876,516],[1876,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1632,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e66ccce50dc44ef84dbbfeb61a39162","type":"text","conversion_output":true,"text":"During the Consolidation phase of treatment extremely high doses of chemotherapy are given to","text_display":"\n\nDuring the Consolidation phase of treatment extremely high doses of chemotherapy are given to","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1876,559],[1876,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1632,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"288c415500194e8b8ee70bea0d9ba045","type":"text","conversion_output":true,"text":"better kill any remaining neuroblastoma cells. It is standard therapy to give one cycle of this","text_display":" better kill any remaining neuroblastoma cells. It is standard therapy to give one cycle of this","confidence":1,"confidence_rate":1},{"cnt":[[245,604],[1876,604],[1876,647],[245,647]],"region":{"top_left_x":244,"top_left_y":603,"width":1632,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61b160b678e445488727f43579a24f43","type":"text","conversion_output":true,"text":"extremely high dose chemotherapy. The high doses of chemotherapy destroy healthy bone","text_display":" extremely high dose chemotherapy. The high doses of chemotherapy destroy healthy bone","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1880,649],[1880,692],[245,692]],"region":{"top_left_x":244,"top_left_y":648,"width":1636,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e818b8ae83884e1cb6f59652911306a8","type":"text","conversion_output":true,"text":"marrow. Bone marrow is the soft tissue in the hollow of flat bones of the body that produces new","text_display":" marrow. Bone marrow is the soft tissue in the hollow of flat bones of the body that produces new","confidence":1,"confidence_rate":1},{"cnt":[[245,692],[1880,692],[1880,737],[245,737]],"region":{"top_left_x":244,"top_left_y":691,"width":1636,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9126481104d14f9c84b7f6b7c9e00da0","type":"text","conversion_output":true,"text":"blood cells. The peripheral blood stem cells that were stored during the Induction phase of","text_display":" blood cells. The peripheral blood stem cells that were stored during the Induction phase of","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1878,735],[1878,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1634,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e831e3a2bfb4679a2d50a2eb19b7d73","type":"text","conversion_output":true,"text":"treatment are given back to the patient after the high dose Consolidation chemotherapy. These","text_display":" treatment are given back to the patient after the high dose Consolidation chemotherapy. These","confidence":1,"confidence_rate":1},{"cnt":[[245,780],[1876,780],[1876,819],[245,819]],"region":{"top_left_x":244,"top_left_y":779,"width":1632,"height":40},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09fb11d6febc47f39f67fdba28c7d1a3","type":"text","conversion_output":true,"text":"stems cells allow the bone marrow to return to normal so that new blood cells can be made.","text_display":" stems cells allow the bone marrow to return to normal so that new blood cells can be made.","confidence":1,"confidence_rate":1},{"cnt":[[245,821],[1878,821],[1878,868],[245,868]],"region":{"top_left_x":244,"top_left_y":820,"width":1634,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36c80100c84c490a9f8ca25db7bff7a2","type":"text","conversion_output":true,"text":"This type of therapy is called a Hematopoietic Stem Cell Transplant. Once the patient has","text_display":" This type of therapy is called a Hematopoietic Stem Cell Transplant. Once the patient has","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1880,868],[1880,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1636,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f09107a956d44c49ac71ad1f803433bd","type":"text","conversion_output":true,"text":"healed from the effects of high doses of chemotherapy, radiation therapy is given to the first","text_display":" healed from the effects of high doses of chemotherapy, radiation therapy is given to the first","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1880,911],[1880,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1636,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31cfc4dc0bf948a88f8d8f78f970c9ae","type":"text","conversion_output":true,"text":"place the tumor was found and to any additional places where the tumor was found after","text_display":" place the tumor was found and to any additional places where the tumor was found after","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[552,954],[552,999],[245,999]],"region":{"top_left_x":244,"top_left_y":953,"width":309,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"670998f806614348be18df35f32104e8","type":"text","conversion_output":true,"text":"Induction therapy.","text_display":" Induction therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1878,1042],[1878,1087],[245,1087]],"region":{"top_left_x":244,"top_left_y":1041,"width":1634,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"205a1510c32a454b95afe441e90dbebe","type":"text","conversion_output":true,"text":"During the third phase of therapy, Maintenance, an oral drug, called cis-retinoic acid (Accutane)","text_display":"\n\nDuring the third phase of therapy, Maintenance, an oral drug, called cis-retinoic acid (Accutane)","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[391,1087],[391,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1087,"width":148,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fca77dd59e7d4c7ab31dc78562b0966d","type":"text","conversion_output":true,"text":"is given.","text_display":" is given.","confidence":1,"confidence_rate":1},{"cnt":[[241,1169],[904,1169],[904,1214],[241,1214]],"region":{"top_left_x":240,"top_left_y":1168,"width":665,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e27772641051417fb0972347922a5635","type":"section_header","conversion_output":false,"children_ids":["153daae6b44c4adc8088023f39d92920"],"text":"","text_display":""},{"cnt":[[245,1173],[900,1173],[900,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1173,"width":657,"height":37},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"153daae6b44c4adc8088023f39d92920","type":"text","conversion_output":true,"parent_id":"e27772641051417fb0972347922a5635","text":"WHY IS THIS STUDY BEING DONE?","text_display":"\n\n\\section*{WHY IS THIS STUDY BEING DONE?}","confidence":1,"confidence_rate":1},{"cnt":[[245,1255],[1878,1255],[1878,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1254,"width":1634,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef17a7cf2a5344ddac0823c2e9fb993a","type":"text","conversion_output":true,"text":"Most of the patients enrolled on this study have very high risk neuroblastoma. The main","text_display":"\n\nMost of the patients enrolled on this study have very high risk neuroblastoma. The main","confidence":1,"confidence_rate":1},{"cnt":[[245,1298],[1880,1298],[1880,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1297,"width":1636,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e3ebefb732c42e1b24d4ccfe6173c62","type":"text","conversion_output":true,"text":"goal of this study applies to them. That goal is to find out if using 2 cycles of high dose","text_display":" goal of this study applies to them. That goal is to find out if using 2 cycles of high dose","confidence":0.99658203125,"confidence_rate":0.9999654165237842},{"cnt":[[245,1341],[1878,1341],[1878,1384],[245,1384]],"region":{"top_left_x":244,"top_left_y":1340,"width":1634,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ec10ef91e7c4423a94443b54fb0ba75","type":"text","conversion_output":true,"text":"Consolidation chemotherapy, instead of 1 cycle, will decrease the chance that the","text_display":" Consolidation chemotherapy, instead of 1 cycle, will decrease the chance that the","confidence":0.9819421768188477,"confidence_rate":0.999795269775398},{"cnt":[[245,1379],[1880,1379],[1880,1424],[245,1424]],"region":{"top_left_x":244,"top_left_y":1379,"width":1636,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0f998ffefe84eeda8cf79c8147cd3f5","type":"text","conversion_output":true,"text":"neuroblastoma will grow back after therapy. However, some types of high risk","text_display":" neuroblastoma will grow back after therapy. However, some types of high risk","confidence":1,"confidence_rate":1},{"cnt":[[245,1422],[1270,1422],[1270,1467],[245,1467]],"region":{"top_left_x":244,"top_left_y":1422,"width":1026,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d18a2cb1ca144a7da25d9897d2ad538d","type":"text","conversion_output":true,"text":"neuroblastoma have a lower risk of having tumor grow back.","text_display":" neuroblastoma have a lower risk of having tumor grow back.","confidence":1,"confidence_rate":1},{"cnt":[[245,1504],[1858,1504],[1858,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1503,"width":1615,"height":47},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b82795ad37d43d8b3b264b47f724638","type":"text","conversion_output":true,"text":"These types of neuroblastoma are described as being in one of two groups. These groups are:","text_display":"\n\nThese types of neuroblastoma are described as being in one of two groups. These groups are:","confidence":1,"confidence_rate":1},{"cnt":[[309,1547],[1876,1547],[1876,1592],[309,1592]],"region":{"top_left_x":309,"top_left_y":1546,"width":1567,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38af0c42b30f4e2ea5470bcde279bd5e","type":"text","conversion_output":true,"text":"- Patients who are between the ages of 12 and 18 months at diagnosis of neuroblastoma.","text_display":"\n- Patients who are between the ages of 12 and 18 months at diagnosis of neuroblastoma.","confidence":1,"confidence_rate":1},{"cnt":[[370,1590],[1876,1590],[1876,1635],[370,1635]],"region":{"top_left_x":369,"top_left_y":1589,"width":1507,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27a4fc4d68be457f8bf39518ebc9a3e1","type":"text","conversion_output":true,"text":"Their neuroblastoma tumor has spread to distant sites (stage 4), does not have","text_display":" Their neuroblastoma tumor has spread to distant sites (stage 4), does not have","confidence":1,"confidence_rate":1},{"cnt":[[370,1629],[1880,1629],[1880,1674],[370,1674]],"region":{"top_left_x":369,"top_left_y":1628,"width":1511,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdec6b7096d8470c8d8349c6a85846b4","type":"text","conversion_output":true,"text":"increased levels of the MYCN gene, but does have other high risk biologic","text_display":" increased levels of the MYCN gene, but does have other high risk biologic","confidence":1,"confidence_rate":1},{"cnt":[[370,1671],[629,1671],[629,1710],[370,1710]],"region":{"top_left_x":369,"top_left_y":1671,"width":261,"height":40},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67d658ea74b64cc384f5aeaf9353d8d0","type":"text","conversion_output":true,"text":"characteristics.","text_display":" characteristics.","confidence":1,"confidence_rate":1},{"cnt":[[309,1714],[1880,1714],[1880,1760],[309,1760]],"region":{"top_left_x":309,"top_left_y":1714,"width":1571,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97b23155e5c0446d97cb14d200b8ead3","type":"text","conversion_output":true,"text":"- Patients who are greater than 18 months of age at diagnosis of neuroblastoma. Their","text_display":"\n- Patients who are greater than 18 months of age at diagnosis of neuroblastoma. Their","confidence":1,"confidence_rate":1},{"cnt":[[370,1757],[1878,1757],[1878,1798],[370,1798]],"region":{"top_left_x":369,"top_left_y":1757,"width":1509,"height":42},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9441534eac64e909c0295907498932e","type":"text","conversion_output":true,"text":"neuroblastoma tumor has spread locally (stage 3), does not have increased levels of the","text_display":" neuroblastoma tumor has spread locally (stage 3), does not have increased levels of the","confidence":0.97216796875,"confidence_rate":0.9996932353000111},{"cnt":[[370,1796],[1491,1796],[1491,1841],[370,1841]],"region":{"top_left_x":369,"top_left_y":1796,"width":1123,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2a5b2b24ce647978e2647596bf7d770","type":"text","conversion_output":true,"text":"MYCN gene but does have other high risk biologic characteristics.","text_display":" MYCN gene but does have other high risk biologic characteristics.","confidence":1,"confidence_rate":1},{"cnt":[[245,1882],[1880,1882],[1880,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1882,"width":1636,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"347f21980eeb4cfcb4d90fc602be5260","type":"text","conversion_output":true,"text":"Very few patients with high risk neuroblastoma (about \\(5-10 \\%\\) ) have these types of","text_display":"\n\nVery few patients with high risk neuroblastoma (about \\(5-10 \\%\\) ) have these types of","confidence":0.99169921875,"confidence_rate":0.999906347929685},{"cnt":[[245,1925],[1878,1925],[1878,1970],[245,1970]],"region":{"top_left_x":244,"top_left_y":1925,"width":1634,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d416cbdc8294391b30b6523c0ec1d14","type":"text","conversion_output":true,"text":"neuroblastoma. Previous clinical trials have not always used high dose Consolidation","text_display":" neuroblastoma. Previous clinical trials have not always used high dose Consolidation","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1878,1968],[1878,2015],[245,2015]],"region":{"top_left_x":244,"top_left_y":1967,"width":1634,"height":49},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38e9b000d77d42329c9d6306028a0f87","type":"text","conversion_output":true,"text":"chemotherapy to treat these types of high risk neuroblastoma. We need to learn more about the","text_display":" chemotherapy to treat these types of high risk neuroblastoma. We need to learn more about the","confidence":1,"confidence_rate":1},{"cnt":[[245,2013],[1880,2013],[1880,2060],[245,2060]],"region":{"top_left_x":244,"top_left_y":2013,"width":1636,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b9541c6e617435bab6c9e1aa906663b","type":"text","conversion_output":true,"text":"best way to treat this smaller group. We want to evaluate how patients in this group respond to","text_display":" best way to treat this smaller group. We want to evaluate how patients in this group respond to","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1240,2058],[1240,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2058,"width":996,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d4cbfdb1bcd430d8ee6af1c68c4a1e4","type":"text","conversion_output":true,"text":"treatment after 1 cycle of high dose Consolidation therapy.","text_display":" treatment after 1 cycle of high dose Consolidation therapy.","confidence":0.99951171875,"confidence_rate":0.9999927104668955},{"cnt":[[245,2144],[1878,2144],[1878,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2144,"width":1634,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3579ff8659274526b5b3d6560be0c5f9","type":"text","conversion_output":true,"text":"This research study will also find out if patients whose tumor did not disappear with initial","text_display":"\n\nThis research study will also find out if patients whose tumor did not disappear with initial","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,2187],[1291,2187],[1291,2232],[245,2232]],"region":{"top_left_x":244,"top_left_y":2187,"width":1048,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1f2cf86dea64831ac064df181847423","type":"text","conversion_output":true,"text":"induction therapy will need a higher dose of radiation therapy.","text_display":" induction therapy will need a higher dose of radiation therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,2275],[1880,2275],[1880,2320],[245,2320]],"region":{"top_left_x":244,"top_left_y":2275,"width":1636,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8db1c32bf8ed40f18c0942eb61ec6458","type":"text","conversion_output":true,"text":"The treatment is described in two separate consent forms. You have already read the first","text_display":"\n\nThe treatment is described in two separate consent forms. You have already read the first","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1880,2316],[1880,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2316,"width":1636,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d756fce172d9413eb6c855ca04781c85","type":"text","conversion_output":true,"text":"consent form (Part 1) and completed Part 1 of treatment. We are now presenting Part 2 (the","text_display":" consent form (Part 1) and completed Part 1 of treatment. We are now presenting Part 2 (the","confidence":1,"confidence_rate":1},{"cnt":[[245,2363],[1878,2363],[1878,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2363,"width":1634,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ad1b4e9dc85408f942a38f6ce5cdfeb","type":"text","conversion_output":true,"text":"second consent form) of the study. The second consent (Part 2) will discuss the Consolidation","text_display":" second consent form) of the study. The second consent (Part 2) will discuss the Consolidation","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,2406],[870,2406],[870,2451],[245,2451]],"region":{"top_left_x":244,"top_left_y":2406,"width":627,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"398a2a702375410c8c7023e8cf6b4e89","type":"text","conversion_output":true,"text":"and Maintenance phases of therapy.","text_display":" and Maintenance phases of therapy.","confidence":1,"confidence_rate":1},{"cnt":[[1732,2587],[1876,2587],[1876,2628],[1732,2628]],"region":{"top_left_x":1731,"top_left_y":2586,"width":145,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36143f3d0089425a868bf85a4d06f034","type":"page_info","conversion_output":false,"text":"Page 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It can be given by IV push over","confidence":1,"confidence_rate":1},{"cnt":[[245,520],[1139,520],[1139,565],[245,565]],"region":{"top_left_x":244,"top_left_y":519,"width":895,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec0a6f6cf3ec40dd8e17ca339181a0dc","type":"text","conversion_output":true,"text":"several minutes or by infusion over minutes or hours","text_display":" several minutes or by infusion over minutes or hours","confidence":1,"confidence_rate":1},{"cnt":[[245,563],[1772,563],[1772,610],[245,610]],"region":{"top_left_x":244,"top_left_y":562,"width":1529,"height":49},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86030cd0b46c4846a8b78473ceface25","type":"text","conversion_output":true,"text":"SUBQ - Drug is given by injecting a needle into the tissue just under the skin (SUBQ shot)","text_display":"\nSUBQ - Drug is given by injecting a needle into the tissue just under the skin (SUBQ shot)","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1717,649],[1717,698],[245,698]],"region":{"top_left_x":244,"top_left_y":648,"width":1473,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df03b4070a3e4493b4a6a7c65be5f60b","type":"text","conversion_output":true,"text":"Most drugs on this study will be given using a needle or tubing inserted into a vein (IV).","text_display":"\nMost drugs on this study will be given using a needle or tubing inserted into a vein (IV).","confidence":1,"confidence_rate":1},{"cnt":[[245,739],[445,739],[445,793],[245,793]],"region":{"top_left_x":244,"top_left_y":739,"width":201,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a0d71712035456eb1eb2beb58cbd129","type":"section_header","conversion_output":false,"children_ids":["9df9bbd910ac4fd2a9a4151183411101"],"text":"","text_display":""},{"cnt":[[249,743],[440,743],[440,786],[249,786]],"region":{"top_left_x":249,"top_left_y":743,"width":192,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9df9bbd910ac4fd2a9a4151183411101","type":"text","conversion_output":true,"parent_id":"7a0d71712035456eb1eb2beb58cbd129","text":"Treatment","text_display":"\n\n\\section*{Treatment}","confidence":1,"confidence_rate":1},{"cnt":[[245,831],[1880,831],[1880,879],[245,879]],"region":{"top_left_x":244,"top_left_y":831,"width":1636,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd837433f5014cd2ae6f07f2da706eb5","type":"text","conversion_output":true,"text":"After you finish induction therapy, you will get one cycle of very high dose chemotherapy and a","text_display":"\n\nAfter you finish induction therapy, you will get one cycle of very high dose chemotherapy and a","confidence":1,"confidence_rate":1},{"cnt":[[245,877],[1878,877],[1878,922],[245,922]],"region":{"top_left_x":244,"top_left_y":876,"width":1634,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e26da97f357471e8bbf600bb69da3f1","type":"text","conversion_output":true,"text":"hematopoietic stem cell transplant. The transplant will begin with treatment with very high doses","text_display":" hematopoietic stem cell transplant. The transplant will begin with treatment with very high doses","confidence":1,"confidence_rate":1},{"cnt":[[247,920],[1878,920],[1878,965],[247,965]],"region":{"top_left_x":247,"top_left_y":919,"width":1631,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eae2dc81b941456293eb761ddefc41ac","type":"text","conversion_output":true,"text":"of the chemotherapy drugs carboplatin, etoposide and melphalan. Etoposide and carboplatin","text_display":" of the chemotherapy drugs carboplatin, etoposide and melphalan. Etoposide and carboplatin","confidence":1,"confidence_rate":1},{"cnt":[[245,962],[1878,962],[1878,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":962,"width":1634,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6c6b0bd11cb46d39f5b3b272d67587a","type":"text","conversion_output":true,"text":"are given as a continuous infusion for 4 consecutive days. The drug melphalan is given as a","text_display":" are given as a continuous infusion for 4 consecutive days. The drug melphalan is given as a","confidence":1,"confidence_rate":1},{"cnt":[[245,1005],[1878,1005],[1878,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1005,"width":1634,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04ac54bcfb7c4890bc2149da9c931248","type":"text","conversion_output":true,"text":"daily dose for 3 days. After the high dose chemotherapy treatment, your stored stem cells will","text_display":" daily dose for 3 days. After the high dose chemotherapy treatment, your stored stem cells will","confidence":1,"confidence_rate":1},{"cnt":[[245,1051],[1878,1051],[1878,1096],[245,1096]],"region":{"top_left_x":244,"top_left_y":1050,"width":1634,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69a129e9653b4b53ba16e7d296fc9e9e","type":"text","conversion_output":true,"text":"be given IV (through the central line). These stem cells were collected from you during the","text_display":" be given IV (through the central line). These stem cells were collected from you during the","confidence":1,"confidence_rate":1},{"cnt":[[245,1096],[1876,1096],[1876,1141],[245,1141]],"region":{"top_left_x":244,"top_left_y":1095,"width":1632,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1aa1193b37be46d7a5fb6d5960c89f0d","type":"text","conversion_output":true,"text":"induction phase of therapy and frozen. This is called a Hematopoietic Stem Cell Transplant.","text_display":" induction phase of therapy and frozen. This is called a Hematopoietic Stem Cell Transplant.","confidence":1,"confidence_rate":1},{"cnt":[[245,1139],[1878,1139],[1878,1184],[245,1184]],"region":{"top_left_x":244,"top_left_y":1138,"width":1634,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba8496ec0ded4ef589e38ded4bb81fee","type":"text","conversion_output":true,"text":"You will be given filgrastim (GCSF) starting on the same day you receive your stem cells and","text_display":" You will be given filgrastim (GCSF) starting on the same day you receive your stem cells and","confidence":1,"confidence_rate":1},{"cnt":[[245,1182],[1833,1182],[1833,1227],[245,1227]],"region":{"top_left_x":244,"top_left_y":1181,"width":1589,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da3917182fe347d08f53226e9f00c2a9","type":"text","conversion_output":true,"text":"continuing until your white blood cells have returned to a safe number, usually about 2 weeks.","text_display":" continuing until your white blood cells have returned to a safe number, usually about 2 weeks.","confidence":1,"confidence_rate":1},{"cnt":[[223,1268],[1725,1268],[1725,1553],[223,1553]],"region":{"top_left_x":223,"top_left_y":1267,"width":1503,"height":287},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f9ee331757f465888f06e4418051907","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|}\n\\hline Drug & How the drug will be given & Days \\\\\n\\hline Carboplatin & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Etoposide & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Melphalan & IV over 15-30 minutes & \\(-7,-6,-5\\) \\\\\n\\hline Blood Stem Cells & IV & 0 \\\\\n\\hline Filgrastim (GCSF) & SUBQ (or) IV & \\(0-14\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Drug & How the drug will be given & Days \\\\\n\\hline Carboplatin & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Etoposide & IV over 24 hours & \\(-7,-6,-5,-4\\) \\\\\n\\hline Melphalan & IV over 15-30 minutes & \\(-7,-6,-5\\) \\\\\n\\hline Blood Stem Cells & IV & 0 \\\\\n\\hline Filgrastim (GCSF) & SUBQ (or) IV & \\(0-14\\) \\\\\n\\hline\n\\end{tabular}","confidence":0.7577705383300781,"confidence_rate":0.9991772684244737},{"cnt":[[243,1594],[591,1594],[591,1646],[243,1646]],"region":{"top_left_x":242,"top_left_y":1594,"width":349,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ef6d0db491341fb9d03b7c48727c3ce","type":"section_header","conversion_output":false,"children_ids":["387b608e256946448062fbca32d1a26f"],"text":"","text_display":""},{"cnt":[[247,1598],[587,1598],[587,1644],[247,1644]],"region":{"top_left_x":247,"top_left_y":1598,"width":340,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"387b608e256946448062fbca32d1a26f","type":"text","conversion_output":true,"parent_id":"7ef6d0db491341fb9d03b7c48727c3ce","text":"Radiation Therapy","text_display":"\n\n\\section*{Radiation Therapy}","confidence":0.99951171875,"confidence_rate":0.9999778002237774},{"cnt":[[245,1641],[1878,1641],[1878,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1641,"width":1634,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2073586fb7a44a89aba47c5425f06c22","type":"text","conversion_output":true,"text":"It is standard to give radiation treatment to the area of the main tumor and to areas that still","text_display":"\n\nIt is standard to give radiation treatment to the area of the main tumor and to areas that still","confidence":1,"confidence_rate":1},{"cnt":[[245,1684],[1880,1684],[1880,1729],[245,1729]],"region":{"top_left_x":244,"top_left_y":1684,"width":1636,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10c02208703f4d05973f240916a6a9ab","type":"text","conversion_output":true,"text":"showed signs of active disease at the end of Induction phase of treatment. Radiation therapy","text_display":" showed signs of active disease at the end of Induction phase of treatment. Radiation therapy","confidence":1,"confidence_rate":1},{"cnt":[[245,1729],[1880,1729],[1880,1775],[245,1775]],"region":{"top_left_x":244,"top_left_y":1729,"width":1636,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a20173d6d144611a634a37cb6f67ab5","type":"text","conversion_output":true,"text":"will begin after you have gotten better from the immediate side effects of the high doses of","text_display":" will begin after you have gotten better from the immediate side effects of the high doses of","confidence":1,"confidence_rate":1},{"cnt":[[245,1775],[1878,1775],[1878,1820],[245,1820]],"region":{"top_left_x":244,"top_left_y":1774,"width":1634,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e87fb1178b844c9bbe3c7b5b2f94c071","type":"text","conversion_output":true,"text":"chemotherapy. Radiation therapy usually starts about a month after the transplant. The","text_display":" chemotherapy. Radiation therapy usually starts about a month after the transplant. The","confidence":1,"confidence_rate":1},{"cnt":[[245,1818],[1878,1818],[1878,1863],[245,1863]],"region":{"top_left_x":244,"top_left_y":1817,"width":1634,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa83eb8c344c454f9a83a3c11edf7065","type":"text","conversion_output":true,"text":"radiation therapy doctors will discuss this with you in more detail. The radiation is given in one","text_display":" radiation therapy doctors will discuss this with you in more detail. The radiation is given in one","confidence":1,"confidence_rate":1},{"cnt":[[245,1861],[1878,1861],[1878,1906],[245,1906]],"region":{"top_left_x":244,"top_left_y":1860,"width":1634,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a2a3ba0070546cbab299d8e29e54b7f","type":"text","conversion_output":true,"text":"short session each day, for a period of up to 3 weeks. Radiation to the stomach may cause","text_display":" short session each day, for a period of up to 3 weeks. Radiation to the stomach may cause","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1878,1904],[1878,1951],[245,1951]],"region":{"top_left_x":244,"top_left_y":1903,"width":1634,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5490331ae8744bc0b163ac6a4d5b5ef3","type":"text","conversion_output":true,"text":"nausea and vomiting, and often causes the blood counts to drop temporarily, which may require","text_display":" nausea and vomiting, and often causes the blood counts to drop temporarily, which may require","confidence":1,"confidence_rate":1},{"cnt":[[245,1949],[1878,1949],[1878,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1948,"width":1634,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b5e641f84f346b8b6f134ca2fe797a5","type":"text","conversion_output":true,"text":"treatment with filgrastim (GCSF) or transfusions (give you blood). Other risks are discussed","text_display":" treatment with filgrastim (GCSF) or transfusions (give you blood). Other risks are discussed","confidence":0.9951171875,"confidence_rate":0.9999495397022695},{"cnt":[[245,1994],[363,1994],[363,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1993,"width":120,"height":42},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cec26d95cbae4b2388ca50e44f6962e8","type":"text","conversion_output":true,"text":"below.","text_display":" below.","confidence":1,"confidence_rate":1},{"cnt":[[245,2080],[1878,2080],[1878,2125],[245,2125]],"region":{"top_left_x":244,"top_left_y":2079,"width":1634,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae9af700835f423a8ac16b2b28e9dd7a","type":"text","conversion_output":true,"text":"You will get a higher dose of radiation treatment if x -ray tests performed at the end of Induction","text_display":"\n\nYou will get a higher dose of radiation treatment if x -ray tests performed at the end of Induction","confidence":0.7736439481377602,"confidence_rate":0.9976695966472089},{"cnt":[[245,2125],[1880,2125],[1880,2172],[245,2172]],"region":{"top_left_x":244,"top_left_y":2124,"width":1636,"height":49},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bc6faf8ebb142599e685da4235e0ee7","type":"text","conversion_output":true,"text":"therapy still show tumor (a lump). The higher dose of radiation will only be given to the area","text_display":" therapy still show tumor (a lump). The higher dose of radiation will only be given to the area","confidence":1,"confidence_rate":1},{"cnt":[[245,2170],[1880,2170],[1880,2215],[245,2215]],"region":{"top_left_x":244,"top_left_y":2169,"width":1636,"height":47},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b61f9e2cbbd4963ae2348fc217cb150","type":"text","conversion_output":true,"text":"where tumor is present. This higher dose of radiation is experimental. We are studying whether","text_display":" where tumor is present. This higher dose of radiation is experimental. We are studying whether","confidence":1,"confidence_rate":1},{"cnt":[[245,2213],[1482,2213],[1482,2258],[245,2258]],"region":{"top_left_x":244,"top_left_y":2212,"width":1239,"height":47},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7d76501fe2d40f792b2542c84b360e2","type":"text","conversion_output":true,"text":"this higher dose of radiation will decrease the risk of tumor growing back.","text_display":" this higher dose of radiation will decrease the risk of tumor growing back.","confidence":1,"confidence_rate":1},{"cnt":[[1732,2587],[1876,2587],[1876,2628],[1732,2628]],"region":{"top_left_x":1731,"top_left_y":2586,"width":145,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9363a18e908a47318e5e7556c6897373","type":"page_info","conversion_output":false,"text":"Page 181","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-182","page":182,"lines":[{"cnt":[[247,125],[612,125],[612,187],[247,187]],"region":{"top_left_x":247,"top_left_y":124,"width":366,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"5ed3636d1f2e40e19e9baee125926116","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a7b646f67774b028d84064c21dda928","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,202],[651,202],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":201,"width":321,"height":29},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8f2388a3889e4cba96229ea62592939b","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,249],[930,249],[930,294],[243,294]],"region":{"top_left_x":242,"top_left_y":249,"width":689,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83771044aef94eeaa0391fae0e77fc76","type":"section_header","conversion_output":false,"children_ids":["4ad2d6487d044ecc800a05da221429e5"],"text":"","text_display":""},{"cnt":[[247,254],[926,254],[926,294],[247,294]],"region":{"top_left_x":247,"top_left_y":253,"width":679,"height":42},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ad2d6487d044ecc800a05da221429e5","type":"text","conversion_output":true,"parent_id":"83771044aef94eeaa0391fae0e77fc76","text":"MAINTENANCE PHASE OF THERAPY","text_display":"\n\n\\section*{MAINTENANCE PHASE OF THERAPY}","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1876,296],[1876,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1632,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f619f7fe6b084866af185d2e76cdcdf1","type":"text","conversion_output":true,"text":"Maintenance therapy will begin after you have recovered from effects of radiation therapy. The","text_display":"\n\nMaintenance therapy will begin after you have recovered from effects of radiation therapy. The","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1876,339],[1876,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1632,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9264608e0284cef80f224435e600187","type":"text","conversion_output":true,"text":"use of an immune therapy that targets neuroblastoma (a medicine called chimeric 14.18","text_display":" use of an immune therapy that targets neuroblastoma (a medicine called chimeric 14.18","confidence":1,"confidence_rate":1},{"cnt":[[245,385],[1876,385],[1876,428],[245,428]],"region":{"top_left_x":244,"top_left_y":384,"width":1632,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a716d3f0f52420d9a40639b126885be","type":"text","conversion_output":true,"text":"antibody) combined with the prior standard therapy of cis-Retinoic acid (Accutane) has recently","text_display":" antibody) combined with the prior standard therapy of cis-Retinoic acid (Accutane) has recently","confidence":0.9975600242614746,"confidence_rate":0.9999755707250964},{"cnt":[[245,430],[1876,430],[1876,471],[245,471]],"region":{"top_left_x":244,"top_left_y":429,"width":1632,"height":42},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4525b0c7065d4dc083ff1f1f0d62e785","type":"text","conversion_output":true,"text":"been shown to improve survival for children with high risk neuroblastoma. Chimeric 14.18","text_display":" been shown to improve survival for children with high risk neuroblastoma. Chimeric 14.18","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1878,473],[1878,516],[245,516]],"region":{"top_left_x":244,"top_left_y":472,"width":1634,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b213208136e442a93e1b60379fd7b6a","type":"text","conversion_output":true,"text":"antibody is only available to patients with high risk neuroblastoma by enrolling onto another","text_display":" antibody is only available to patients with high risk neuroblastoma by enrolling onto another","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1876,516],[1876,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1632,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db73967c9de84efaa5aeffbfa06e3bf9","type":"text","conversion_output":true,"text":"clinical trial. 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This can happen if","confidence":1,"confidence_rate":1},{"cnt":[[245,2103],[1880,2103],[1880,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2103,"width":1636,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7da10295f3d43bf9363450a3cd7a8f2","type":"text","conversion_output":true,"text":"the stem cells were injured in your body even before they were removed or if the stem cells are","text_display":" the stem cells were injured in your body even before they were removed or if the stem cells are","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1880,2144],[1880,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2144,"width":1636,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5fd9d94ae43410aa931828ebb8020f7","type":"text","conversion_output":true,"text":"injured during the collection, freezing or thawing processes. 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You will be more likely to develop an infection in the months after transplant,","confidence":1,"confidence_rate":1},{"cnt":[[245,2350],[649,2350],[649,2400],[245,2400]],"region":{"top_left_x":244,"top_left_y":2350,"width":405,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a61f2e5883e44fad91dd7f3fb65150dc","type":"text","conversion_output":true,"text":"especially from viruses.","text_display":" especially from viruses.","confidence":1,"confidence_rate":1},{"cnt":[[1729,2587],[1880,2587],[1880,2628],[1729,2628]],"region":{"top_left_x":1729,"top_left_y":2586,"width":151,"height":42},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b7cf6e782c04cf7a18422006e537a23","type":"page_info","conversion_output":false,"text":"Page 184","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"7e9a11d0-792e-4d29-97ca-9108a5b06777-185","page":185,"lines":[{"cnt":[[247,125],[612,125],[612,187],[247,187]],"region":{"top_left_x":247,"top_left_y":124,"width":366,"height":63},"line":1,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"b33476749a234408a28ba54f4579a065","type":"page_info","conversion_output":false,"text":"CureSearch","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1706,129],[1876,129],[1876,161],[1706,161]],"region":{"top_left_x":1705,"top_left_y":128,"width":171,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bced09b7b05044f1b3181befbe0bd438","type":"page_info","conversion_output":false,"text":"ANBL0532","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[331,200],[651,200],[651,230],[331,230]],"region":{"top_left_x":330,"top_left_y":199,"width":321,"height":31},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"562d93efb64b4640b44b58b46ec8578d","type":"page_info","conversion_output":false,"text":"Children's Oncology Group","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,254],[1876,254],[1876,299],[245,299]],"region":{"top_left_x":244,"top_left_y":253,"width":1632,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b331e6ac49248429f9ce82ede6bd547","type":"text","conversion_output":true,"text":"There is also a small risk of severe organ damage, especially to liver and kidney, with an even","text_display":"\n\nThere is also a small risk of severe organ damage, especially to liver and kidney, with an even","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1876,296],[1876,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1632,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddf530cac6184d789c2bac2f8c88735d","type":"text","conversion_output":true,"text":"smaller risk to the heart and lungs. Though rare, the kidney damage can be severe enough to","text_display":" smaller risk to the heart and lungs. Though rare, the kidney damage can be severe enough to","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1876,339],[1876,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1632,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b7acbe9e9f84a369eda5d493de2613d","type":"text","conversion_output":true,"text":"require dialysis. The liver damage can also be severe, resulting in jaundice and, occasionally,","text_display":" require dialysis. 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As a","text_display":"\n- Cyclophosphamide and melphalan will cause damage to the sexual glands. As a","confidence":1,"confidence_rate":1},{"cnt":[[432,1100],[1772,1100],[1772,1147],[432,1147]],"region":{"top_left_x":431,"top_left_y":1100,"width":1342,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3102c827a1fc4eba89ae7a7708dc4c8b","type":"text","conversion_output":true,"text":"result, if you are a boy, you will almost certainly not be able to have biologically","text_display":" result, if you are a boy, you will almost certainly not be able to have biologically","confidence":1,"confidence_rate":1},{"cnt":[[434,1145],[1734,1145],[1734,1192],[434,1192]],"region":{"top_left_x":433,"top_left_y":1145,"width":1301,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ba30f5f97b246658ce5e4c75a7a2e77","type":"text","conversion_output":true,"text":"related children, and, if you are girl, you are likely to need hormones or other","text_display":" related children, and, if you are girl, you are likely to need hormones or other","confidence":1,"confidence_rate":1},{"cnt":[[432,1190],[947,1190],[947,1231],[432,1231]],"region":{"top_left_x":431,"top_left_y":1190,"width":517,"height":42},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efdba6785ee7442ca75a6287bcc87fb4","type":"text","conversion_output":true,"text":"interventions to have children.","text_display":" interventions to have children.","confidence":1,"confidence_rate":1},{"cnt":[[243,1272],[582,1272],[582,1326],[243,1326]],"region":{"top_left_x":242,"top_left_y":1271,"width":341,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcf0fbe088554b2ab95dbfd10127150b","type":"section_header","conversion_output":false,"children_ids":["cf11f742815e403ca8fa275b429a7bd2"],"text":"","text_display":""},{"cnt":[[245,1276],[578,1276],[578,1321],[245,1321]],"region":{"top_left_x":244,"top_left_y":1276,"width":334,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf11f742815e403ca8fa275b429a7bd2","type":"text","conversion_output":true,"parent_id":"fcf0fbe088554b2ab95dbfd10127150b","text":"Reproductive risks:","text_display":"\n\n\\section*{Reproductive risks:}","confidence":1,"confidence_rate":1},{"cnt":[[245,1319],[1878,1319],[1878,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1319,"width":1634,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5be9163c0ffd4720b9aeb4eaaa2e2b1f","type":"text","conversion_output":true,"text":"It is unknown what effect(s) these treatments may have on an unborn child. As the drugs","text_display":"\n\nIt is unknown what effect(s) these treatments may have on an unborn child. As the drugs","confidence":1,"confidence_rate":1},{"cnt":[[245,1366],[1876,1366],[1876,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1366,"width":1632,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f097506049f4aebbc804627eb05066c","type":"text","conversion_output":true,"text":"and/or radiation therapy in this study can affect a developing fetus (unborn baby in the womb),","text_display":" and/or radiation therapy in this study can affect a developing fetus (unborn baby in the womb),","confidence":1,"confidence_rate":1},{"cnt":[[245,1409],[1878,1409],[1878,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1409,"width":1634,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5a1836628304055905e90392c0cc96f","type":"text","conversion_output":true,"text":"you should not become pregnant or father a baby while on this study. 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