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Javier Hurtado \\({ }^{5}\\), Gilberto Friedman \\({ }^{6}\\), Ricardo Castro \\({ }^{1}\\), Leyla Alegría \\({ }^{1}\\), Maurizio Cecconi \\({ }^{7}\\),","confidence":0.9956123778846402,"confidence_rate":0.9999762312231415},{"cnt":[[249,907],[1523,907],[1523,956],[249,956]],"region":{"top_left_x":249,"top_left_y":906,"width":1275,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5029f6aeda944f1e9700024764a3e166","type":"text","conversion_output":true,"parent_id":"fbc08c03eb5d4442a0904051bd23f7c1","text":"Jean-Louis Teboul \\({ }^{8}\\) and Jan Bakker \\({ }^{1,9,10,11}\\) The ANDROMEDA-SHOCK Study Investigators","text_display":" Jean-Louis Teboul \\({ }^{8}\\) and Jan Bakker \\({ }^{1,9,10,11}\\) The ANDROMEDA-SHOCK Study Investigators\n}","confidence":0.9858465194702148,"confidence_rate":0.9998692324383253},{"cnt":[[264,1055],[1852,1055],[1852,2075],[264,2075]],"region":{"top_left_x":264,"top_left_y":1054,"width":1588,"height":1022},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f98e520607b74b3b872f6e263dc76e7c","type":"abstract","conversion_output":false,"children_ids":["0415f3c3a1c94280909988d7b796ccf4","969d6454be3c4e0a99dd7bc14ce01812","f20f76a9b63c46f8a11ae3db4dc9432a","9bd44d5f03204da3a48642e5543ca7a1","1053c197638040fba6367904d2e83334","f43279bbabdd4ef5bc8408cd63af2b67","a5222bd15a754267b5dabd3c8516fb08","47d6919bbe4a4a0ea4f069b46d0454d7","85122757f86e48a58e79131b25324602","38ded45138284ad3a166c2d34d653941","01491f939acd4e21a50fffd047695e66","ac9221689cc2417ead90f8e2f6edbfc7","8d7a47e40a9a4d4fb29e59e62e2566ea","e22a75b634ee4c03a13d3563b9f4ef4a","de5ec5f9c0d84279a111e4c803f750f5","d90fe5e87e54492bb875774a405d10db","fc88ce66dad54633a2bfc6cf90859961","e380f2e2a9f34a8c8baca8b390be07e0","6fd1e00039e646fe9b575f2985fa709e","a6b24b268ad54b68a8e316500fc8baad","787024ead7564e7aa7589fc0bdd31802","02e6eba0fb694c32aac24ec7b4bbffdd","d90be419b4344cb184b79c0d13837c2e","c581977050c744f39363d0a0b67224f0"],"text":"","text_display":""},{"cnt":[[271,1061],[410,1061],[410,1094],[271,1094]],"region":{"top_left_x":270,"top_left_y":1061,"width":141,"height":33},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0415f3c3a1c94280909988d7b796ccf4","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"Abstract","text_display":"\n\n\\begin{abstract}\n","confidence":1,"confidence_rate":1},{"cnt":[[271,1111],[1796,1111],[1796,1149],[271,1149]],"region":{"top_left_x":270,"top_left_y":1110,"width":1527,"height":40},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"969d6454be3c4e0a99dd7bc14ce01812","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"Background: Septic shock is a highly lethal condition. Early recognition of tissue hypoperfusion and its reversion","text_display":"Background: Septic shock is a highly lethal condition. Early recognition of tissue hypoperfusion and its reversion","confidence":0.99951171875,"confidence_rate":0.9999958958025558},{"cnt":[[271,1152],[1837,1152],[1837,1188],[271,1188]],"region":{"top_left_x":270,"top_left_y":1151,"width":1567,"height":38},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f20f76a9b63c46f8a11ae3db4dc9432a","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"are key factors for limiting progression to multiple organ dysfunction and death. Lactate-targeted resuscitation is the","text_display":" are key factors for limiting progression to multiple organ dysfunction and death. Lactate-targeted resuscitation is the","confidence":0.99560546875,"confidence_rate":0.9999644827631314},{"cnt":[[271,1190],[1833,1190],[1833,1231],[271,1231]],"region":{"top_left_x":270,"top_left_y":1190,"width":1563,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bd44d5f03204da3a48642e5543ca7a1","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"gold-standard under current guidelines, although it has several pitfalls including that non-hypoxic sources of lactate","text_display":" gold-standard under current guidelines, although it has several pitfalls including that non-hypoxic sources of lactate","confidence":1,"confidence_rate":1},{"cnt":[[271,1233],[1841,1233],[1841,1270],[271,1270]],"region":{"top_left_x":270,"top_left_y":1233,"width":1572,"height":37},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1053c197638040fba6367904d2e83334","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"might predominate in an unknown proportion of patients. Peripheral perfusion-targeted resuscitation might provide","text_display":" might predominate in an unknown proportion of patients. Peripheral perfusion-targeted resuscitation might provide","confidence":0.98388671875,"confidence_rate":0.999862344121384},{"cnt":[[271,1272],[1846,1272],[1846,1313],[271,1313]],"region":{"top_left_x":270,"top_left_y":1271,"width":1576,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f43279bbabdd4ef5bc8408cd63af2b67","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"a real-time response to increases in flow that could lead to a more timely decision to stop resuscitation, thus avoiding","text_display":" a real-time response to increases in flow that could lead to a more timely decision to stop resuscitation, thus avoiding","confidence":1,"confidence_rate":1},{"cnt":[[271,1313],[1811,1313],[1811,1351],[271,1351]],"region":{"top_left_x":270,"top_left_y":1312,"width":1542,"height":40},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5222bd15a754267b5dabd3c8516fb08","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"fluid overload and the risks of over-resuscitation. This article reports the rationale, study design and analysis plan of","text_display":" fluid overload and the risks of over-resuscitation. This article reports the rationale, study design and analysis plan of","confidence":1,"confidence_rate":1},{"cnt":[[271,1354],[711,1354],[711,1394],[271,1394]],"region":{"top_left_x":270,"top_left_y":1353,"width":442,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47d6919bbe4a4a0ea4f069b46d0454d7","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"the ANDROMEDA-SHOCK Study.","text_display":" the ANDROMEDA-SHOCK Study.","confidence":0.99951171875,"confidence_rate":0.9999842452693294},{"cnt":[[271,1405],[1826,1405],[1826,1444],[271,1444]],"region":{"top_left_x":270,"top_left_y":1405,"width":1557,"height":39},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85122757f86e48a58e79131b25324602","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"Methods: ANDROMEDA-SHOCK is a randomized controlled trial which aims to determine if a peripheral perfusion-","text_display":"\nMethods: ANDROMEDA-SHOCK is a randomized controlled trial which aims to determine if a peripheral perfusion","confidence":1,"confidence_rate":1},{"cnt":[[271,1444],[1762,1444],[1762,1485],[271,1485]],"region":{"top_left_x":270,"top_left_y":1443,"width":1492,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38ded45138284ad3a166c2d34d653941","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"targeted resuscitation is associated with lower 28-day mortality compared to a lactate-targeted resuscitation in","text_display":"targeted resuscitation is associated with lower 28-day mortality compared to a lactate-targeted resuscitation in","confidence":0.9926791191101074,"confidence_rate":0.9999372001767008},{"cnt":[[271,1487],[1760,1487],[1760,1523],[271,1523]],"region":{"top_left_x":270,"top_left_y":1486,"width":1490,"height":38},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01491f939acd4e21a50fffd047695e66","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"patients with septic shock with less than 4 h of diagnosis. Both groups will be treated with the same sequential","text_display":" patients with septic shock with less than 4 h of diagnosis. Both groups will be treated with the same sequential","confidence":0.84375,"confidence_rate":0.9986083541826691},{"cnt":[[273,1525],[1781,1525],[1781,1566],[273,1566]],"region":{"top_left_x":272,"top_left_y":1525,"width":1510,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac9221689cc2417ead90f8e2f6edbfc7","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"approach during the 8-hour study period pursuing normalization of capillary refill time versus normalization or a","text_display":" approach during the 8-hour study period pursuing normalization of capillary refill time versus normalization or a","confidence":0.9794921875,"confidence_rate":0.9998244135727157},{"cnt":[[271,1566],[1811,1566],[1811,1605],[271,1605]],"region":{"top_left_x":270,"top_left_y":1566,"width":1542,"height":39},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d7a47e40a9a4d4fb29e59e62e2566ea","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"decrease of more than 20\\% of lactate every 2 h . The common protocol starts with fluid responsiveness assessment","text_display":" decrease of more than 20\\% of lactate every 2 h . The common protocol starts with fluid responsiveness assessment","confidence":0.85986328125,"confidence_rate":0.9987632090828034},{"cnt":[[271,1607],[1815,1607],[1815,1644],[271,1644]],"region":{"top_left_x":270,"top_left_y":1607,"width":1546,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e22a75b634ee4c03a13d3563b9f4ef4a","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"and fluid loading in responders, followed by a vasopressor and an inodilator test if necessary. The primary outcome","text_display":" and fluid loading in responders, followed by a vasopressor and an inodilator test if necessary. The primary outcome","confidence":1,"confidence_rate":1},{"cnt":[[271,1646],[1828,1646],[1828,1687],[271,1687]],"region":{"top_left_x":270,"top_left_y":1645,"width":1559,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de5ec5f9c0d84279a111e4c803f750f5","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"is 28-day mortality, and the secondary outcomes are: free days of mechanical ventilation, renal replacement therapy","text_display":" is 28-day mortality, and the secondary outcomes are: free days of mechanical ventilation, renal replacement therapy","confidence":0.97021484375,"confidence_rate":0.9997480505478655},{"cnt":[[271,1687],[1848,1687],[1848,1725],[271,1725]],"region":{"top_left_x":270,"top_left_y":1686,"width":1578,"height":40},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d90fe5e87e54492bb875774a405d10db","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"and vasopressor support during the first 28 days after randomization; multiple organ dysfunction during the first 72 h","text_display":" and vasopressor support during the first 28 days after randomization; multiple organ dysfunction during the first 72 h","confidence":0.9970722198486328,"confidence_rate":0.9999769130658488},{"cnt":[[271,1727],[1824,1727],[1824,1766],[271,1766]],"region":{"top_left_x":270,"top_left_y":1727,"width":1555,"height":40},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc88ce66dad54633a2bfc6cf90859961","type":"text","conversion_output":true,"parent_id":"f98e520607b74b3b872f6e263dc76e7c","text":"after randomization; intensive care unit and hospital lengths of stay; and all-cause mortality at 90-day. A sample size","text_display":" after randomization; intensive care unit and hospital lengths of stay; and all-cause mortality at 90-day. 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The","text_display":" intraabdominal visceral organ perfusion [16, 17]. The","confidence":1,"confidence_rate":1},{"cnt":[[249,1388],[1044,1388],[1044,1427],[249,1427]],"region":{"top_left_x":249,"top_left_y":1387,"width":796,"height":40},"line":31,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c611552494ad4df9be06d69b31d43acb","type":"text","conversion_output":true,"parent_id":"b6c1f3f126124bb28f7a51506c0b5a17","text":"skin territory lacks auto-regulatory flow control, and","text_display":" skin territory lacks auto-regulatory flow control, and","confidence":1,"confidence_rate":1},{"cnt":[[249,1429],[1044,1429],[1044,1467],[249,1467]],"region":{"top_left_x":249,"top_left_y":1428,"width":796,"height":40},"line":32,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"112f2ab7de21423caaea60c8ef6b2afe","type":"text","conversion_output":true,"parent_id":"b6c1f3f126124bb28f7a51506c0b5a17","text":"therefore, sympathetic activation impairs skin perfusion","text_display":" therefore, sympathetic activation impairs skin perfusion","confidence":1,"confidence_rate":1},{"cnt":[[249,1470],[1044,1470],[1044,1506],[249,1506]],"region":{"top_left_x":249,"top_left_y":1469,"width":796,"height":38},"line":33,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13e146ff1df149938b83a9b4c5a33511","type":"text","conversion_output":true,"parent_id":"b6c1f3f126124bb28f7a51506c0b5a17","text":"during circulatory dysfunction [17], a phenomenon that","text_display":" during circulatory dysfunction [17], a phenomenon that","confidence":1,"confidence_rate":1},{"cnt":[[249,1508],[1044,1508],[1044,1549],[249,1549]],"region":{"top_left_x":249,"top_left_y":1508,"width":796,"height":42},"line":34,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df7542b8e8454053bb2ae14a4bbd7cdc","type":"text","conversion_output":true,"parent_id":"b6c1f3f126124bb28f7a51506c0b5a17","text":"could be evaluated by peripheral perfusion assessment. 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The use of other therapies","text_display":" optimize arterial \\(O _{2}\\) content. The use of other therapies","confidence":1,"confidence_rate":1},{"cnt":[[1087,1912],[1880,1912],[1880,1953],[1087,1953]],"region":{"top_left_x":1087,"top_left_y":1912,"width":793,"height":41},"line":78,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"049f29c0d9b945ca8e607c3baff161da","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"such as epinephrine, vasopressin analogues, steroids or","text_display":" such as epinephrine, vasopressin analogues, steroids or","confidence":1,"confidence_rate":1},{"cnt":[[1087,1951],[1880,1951],[1880,1992],[1087,1992]],"region":{"top_left_x":1087,"top_left_y":1950,"width":793,"height":42},"line":79,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c986e300894940f9864d137ec751c0c4","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"different blood purification techniques like high-volume","text_display":" different blood purification techniques like high-volume","confidence":1,"confidence_rate":1},{"cnt":[[1085,1989],[1880,1989],[1880,2030],[1085,2030]],"region":{"top_left_x":1084,"top_left_y":1989,"width":796,"height":42},"line":80,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dca6706fe1ce47dd8e6e2379e8618f87","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"hemofiltration (HVHF) will be provided according to the","text_display":" hemofiltration (HVHF) will be provided according to the","confidence":1,"confidence_rate":1},{"cnt":[[1087,2032],[1880,2032],[1880,2073],[1087,2073]],"region":{"top_left_x":1087,"top_left_y":2032,"width":793,"height":42},"line":81,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ece2e01e155457389d86b096dfd8041","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"usual practice at the involved centers in patients evolv-","text_display":" usual practice at the involved centers in patients evolv","confidence":1,"confidence_rate":1},{"cnt":[[1087,2073],[1880,2073],[1880,2114],[1087,2114]],"region":{"top_left_x":1087,"top_left_y":2073,"width":793,"height":42},"line":82,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2d9a5414dec444e8694e9ae7cac188a","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"ing with refractory septic shock. Finally, stress ulcer and","text_display":"ing with refractory septic shock. Finally, stress ulcer and","confidence":1,"confidence_rate":1},{"cnt":[[1087,2114],[1880,2114],[1880,2155],[1087,2155]],"region":{"top_left_x":1087,"top_left_y":2114,"width":793,"height":41},"line":83,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"add20e291cfe402ca9ec800b737c0497","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"venous thrombosis prophylaxis will be managed accord-","text_display":" venous thrombosis prophylaxis will be managed accord","confidence":1,"confidence_rate":1},{"cnt":[[1085,2153],[1682,2153],[1682,2194],[1085,2194]],"region":{"top_left_x":1084,"top_left_y":2152,"width":599,"height":42},"line":84,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82f7bfeaecc446429c78a595d0d5dd73","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"ing to international recommendations [10].","text_display":"ing to international recommendations [10].","confidence":1,"confidence_rate":1},{"cnt":[[1083,2234],[1291,2234],[1291,2275],[1083,2275]],"region":{"top_left_x":1082,"top_left_y":2234,"width":210,"height":42},"line":85,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38a3ac8d44074b359fa5895d70fb9459","type":"section_header","conversion_output":false,"parent_id":"c43149048a9743cca7a80c9ba550184b","children_ids":["2beaaa293ff046d9a7db3a866fc841c6"],"text":"","text_display":""},{"cnt":[[1087,2239],[1291,2239],[1291,2273],[1087,2273]],"region":{"top_left_x":1087,"top_left_y":2238,"width":205,"height":36},"line":86,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2beaaa293ff046d9a7db3a866fc841c6","type":"text","conversion_output":true,"parent_id":"38a3ac8d44074b359fa5895d70fb9459","text":"Study protocol","text_display":"\n\n\\section*{Study protocol}","confidence":1,"confidence_rate":1},{"cnt":[[1087,2277],[1880,2277],[1880,2314],[1087,2314]],"region":{"top_left_x":1087,"top_left_y":2277,"width":793,"height":37},"line":87,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"267455c3319e47daac7673ea5b3d2f86","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"A sequential approach to resuscitation will be followed","text_display":"\n\nA sequential approach to resuscitation will be followed","confidence":1,"confidence_rate":1},{"cnt":[[1087,2316],[1880,2316],[1880,2357],[1087,2357]],"region":{"top_left_x":1087,"top_left_y":2316,"width":793,"height":41},"line":88,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb4ccd6df8be4008a26d7079c89ae547","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"in both groups as shown in Fig. 2. After fulfilling inclu-","text_display":" in both groups as shown in Fig. 2. After fulfilling inclu","confidence":1,"confidence_rate":1},{"cnt":[[1087,2357],[1880,2357],[1880,2396],[1087,2396]],"region":{"top_left_x":1087,"top_left_y":2356,"width":793,"height":40},"line":89,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01978117476e4070b40cf925e01ba9c6","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"sion criteria and discarding all exclusion conditions, an","text_display":"sion criteria and discarding all exclusion conditions, an","confidence":1,"confidence_rate":1},{"cnt":[[1087,2398],[1880,2398],[1880,2430],[1087,2430]],"region":{"top_left_x":1087,"top_left_y":2397,"width":793,"height":33},"line":90,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bdde8e6d7054f8690188ddf0ee5d008","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"informed consent will be obtained. Basal measurements","text_display":" informed consent will be obtained. Basal measurements","confidence":1,"confidence_rate":1},{"cnt":[[1087,2436],[1880,2436],[1880,2477],[1087,2477]],"region":{"top_left_x":1087,"top_left_y":2436,"width":793,"height":42},"line":91,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ff313b12f3948728cab516f05833f10","type":"text","conversion_output":true,"parent_id":"c43149048a9743cca7a80c9ba550184b","text":"including hemodynamics and blood sampling will be","text_display":" including hemodynamics and blood sampling will be","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"07a5063c-af33-499a-9fe6-703afe32ad5c-04","page":4,"lines":[{"cnt":[[249,150],[776,150],[776,178],[249,178]],"region":{"top_left_x":249,"top_left_y":150,"width":527,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cf8f976b3baf4fccbe7292bc389fd829","type":"page_info","conversion_output":false,"text":"Hernández et al. Ann. 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