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BACKGROUND}","confidence":0.99951171875,"confidence_rate":0.9999728670071003},{"cnt":[[449,432],[1502,432],[1502,479],[449,479]],"region":{"top_left_x":449,"top_left_y":431,"width":1053,"height":49},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f7e700e39df44e584fe65f73ed71579","type":"section_header","conversion_output":false,"children_ids":["4e7bf04d6cfe417595f8ba9c28eedad3"],"text":"","text_display":""},{"cnt":[[451,434],[1497,434],[1497,475],[451,475]],"region":{"top_left_x":451,"top_left_y":433,"width":1047,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e7bf04d6cfe417595f8ba9c28eedad3","type":"text","conversion_output":true,"parent_id":"3f7e700e39df44e584fe65f73ed71579","text":"1.1 BACKGROUND ON ACUTE ISCHEMIC STROKE","text_display":"\n\n\\subsection*{1.1 BACKGROUND ON ACUTE ISCHEMIC STROKE}","confidence":0.99951171875,"confidence_rate":0.9999889000502842},{"cnt":[[451,503],[1669,503],[1669,544],[451,544]],"region":{"top_left_x":451,"top_left_y":502,"width":1219,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28452a678bab4dcea0f0207879588569","type":"text","conversion_output":true,"text":"Stroke is the fourth leading cause of death and a leading cause of disability in the","text_display":"\n\nStroke is the fourth leading cause of death and a leading cause of disability in the","confidence":1,"confidence_rate":1},{"cnt":[[451,546],[1674,546],[1674,591],[451,591]],"region":{"top_left_x":451,"top_left_y":545,"width":1223,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"defe513cd2a44493a139c919ad9bd837","type":"text","conversion_output":true,"text":"United States (U.S.). Nearly 800,000 strokes occur in the U.S. annually; of these,","text_display":" United States (U.S.). Nearly 800,000 strokes occur in the U.S. annually; of these,","confidence":0.99267578125,"confidence_rate":0.9999155073337173},{"cnt":[[451,593],[1747,593],[1747,634],[451,634]],"region":{"top_left_x":451,"top_left_y":592,"width":1296,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68d3d8cdd1f94d6e8019ec00f54a80bc","type":"text","conversion_output":true,"text":"approximately \\(85 \\%\\) are ischemic in nature (Rosamond et al. 2007). Treatment options","text_display":" approximately \\(85 \\%\\) are ischemic in nature (Rosamond et al. 2007). Treatment options","confidence":0.97412109375,"confidence_rate":0.9997087129119303},{"cnt":[[451,640],[1725,640],[1725,681],[451,681]],"region":{"top_left_x":451,"top_left_y":640,"width":1275,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50ef2874d78e48fd9afc8318077b8d75","type":"text","conversion_output":true,"text":"are limited, as the only approved therapy for acute ischemic stroke (AIS) is alteplase,","text_display":" are limited, as the only approved therapy for acute ischemic stroke (AIS) is alteplase,","confidence":1,"confidence_rate":1},{"cnt":[[451,688],[1783,688],[1783,728],[451,728]],"region":{"top_left_x":451,"top_left_y":687,"width":1333,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a48fa04bdcfe4e249a915c16e93c2a42","type":"text","conversion_output":true,"text":"which is to be used in eligible patients and started within 3 hours from the onset of stroke","text_display":" which is to be used in eligible patients and started within 3 hours from the onset of stroke","confidence":1,"confidence_rate":1},{"cnt":[[451,735],[1772,735],[1772,776],[451,776]],"region":{"top_left_x":451,"top_left_y":734,"width":1322,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f81c04e1b2d468eaa0e42e46f70cb3f","type":"text","conversion_output":true,"text":"symptoms. Stroke with \"only minor or rapidly improving stroke symptoms\" is considered","text_display":" symptoms. Stroke with \"only minor or rapidly improving stroke symptoms\" is considered","confidence":1,"confidence_rate":1},{"cnt":[[451,778],[1656,778],[1656,821],[451,821]],"region":{"top_left_x":451,"top_left_y":777,"width":1206,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bb68ae6deef43769930e9a578714255","type":"text","conversion_output":true,"text":"a relative exclusion by national clinical guidelines, as these patients were largely","text_display":" a relative exclusion by national clinical guidelines, as these patients were largely","confidence":1,"confidence_rate":1},{"cnt":[[451,825],[1613,825],[1613,866],[451,866]],"region":{"top_left_x":451,"top_left_y":825,"width":1163,"height":41},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f7204e90c964e9b98289a223ca84172","type":"text","conversion_output":true,"text":"excluded from definitive trials to date (Jauch et al. 2013). Consistent with this","text_display":" excluded from definitive trials to date (Jauch et al. 2013). Consistent with this","confidence":1,"confidence_rate":1},{"cnt":[[451,870],[1768,870],[1768,913],[451,913]],"region":{"top_left_x":451,"top_left_y":870,"width":1318,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a15086a164204d578628bb7c94211927","type":"text","conversion_output":true,"text":"recommendation, only \\(15 \\%\\) of alteplase recipients have mild strokes (Smith et al. 2011).","text_display":" recommendation, only \\(15 \\%\\) of alteplase recipients have mild strokes (Smith et al. 2011).","confidence":0.9921989440917969,"confidence_rate":0.9999175650471602},{"cnt":[[451,956],[1751,956],[1751,999],[451,999]],"region":{"top_left_x":451,"top_left_y":956,"width":1300,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee5d3e97a5824c3a8cef687c761fd6ce","type":"text","conversion_output":true,"text":"More than half of all ischemic stroke patients have mild strokes at initial presentation in","text_display":"\n\nMore than half of all ischemic stroke patients have mild strokes at initial presentation in","confidence":1,"confidence_rate":1},{"cnt":[[451,1001],[1768,1001],[1768,1042],[451,1042]],"region":{"top_left_x":451,"top_left_y":1001,"width":1318,"height":41},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2dc196fae310487698cde8430fcb4bc8","type":"text","conversion_output":true,"text":"population-based studies (Dhamoon et al. 2009; Reeves et al. 2013). Yet, a substantial","text_display":" population-based studies (Dhamoon et al. 2009; Reeves et al. 2013). Yet, a substantial","confidence":1,"confidence_rate":1},{"cnt":[[451,1048],[1704,1048],[1704,1089],[451,1089]],"region":{"top_left_x":451,"top_left_y":1048,"width":1253,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d72d49b9e0a4f4fa0f3044969bfa90a","type":"text","conversion_output":true,"text":"proportion \\((31 \\%-52 \\%)\\) of ischemic stroke patients who arrive within \\(2-3\\) hours of","text_display":" proportion \\((31 \\%-52 \\%)\\) of ischemic stroke patients who arrive within \\(2-3\\) hours of","confidence":0.8681640625,"confidence_rate":0.9984304045489206},{"cnt":[[451,1096],[1699,1096],[1699,1137],[451,1137]],"region":{"top_left_x":451,"top_left_y":1095,"width":1249,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acf408bebbb34629aff05107be634b9f","type":"text","conversion_output":true,"text":"symptom onset are not treated with intravenous (IV) alteplase primarily due to mild","text_display":" symptom onset are not treated with intravenous (IV) alteplase primarily due to mild","confidence":1,"confidence_rate":1},{"cnt":[[451,1139],[1760,1139],[1760,1182],[451,1182]],"region":{"top_left_x":451,"top_left_y":1138,"width":1309,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed7086d29cb747dd8378ac24712267ce","type":"text","conversion_output":true,"text":"symptoms at the time of the treatment decision (Smith et al. 2011; De Los Rios la Rosa","text_display":" symptoms at the time of the treatment decision (Smith et al. 2011; De Los Rios la Rosa","confidence":1,"confidence_rate":1},{"cnt":[[451,1186],[1631,1186],[1631,1227],[451,1227]],"region":{"top_left_x":451,"top_left_y":1185,"width":1180,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"758c5ef39587492c9af8ce2f544be3c8","type":"text","conversion_output":true,"text":"et al. 2012). In a national registry, among 93,517 cases arriving to Emergency","text_display":" et al. 2012). In a national registry, among 93,517 cases arriving to Emergency","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[451,1233],[1656,1233],[1656,1274],[451,1274]],"region":{"top_left_x":451,"top_left_y":1233,"width":1206,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed90d07c9b6b4f0fa6c5e2a7f02077be","type":"text","conversion_output":true,"text":"Departments within 2 hours, \\(29,200(31 \\%)\\) were not treated solely due to mild or","text_display":" Departments within 2 hours, \\(29,200(31 \\%)\\) were not treated solely due to mild or","confidence":0.7213273048400879,"confidence_rate":0.9963363647935235},{"cnt":[[451,1276],[1760,1276],[1760,1319],[451,1319]],"region":{"top_left_x":451,"top_left_y":1276,"width":1309,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa800cdbbf6b4f1aa7b6741cce3fd62d","type":"text","conversion_output":true,"text":"improving symptoms, and \\(80.1 \\%\\) of untreated cases had a National Institutes of Health","text_display":" improving symptoms, and \\(80.1 \\%\\) of untreated cases had a National Institutes of Health","confidence":0.998046875,"confidence_rate":0.9999787498471376},{"cnt":[[451,1323],[1227,1323],[1227,1366],[451,1366]],"region":{"top_left_x":451,"top_left_y":1323,"width":776,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92bef55aca8c4bcf9d8ea3f76e9384ac","type":"text","conversion_output":true,"text":"Stroke Scale (NIHSS) score \\(\\leq 5\\) (Smith et al. 2011).","text_display":" Stroke Scale (NIHSS) score \\(\\leq 5\\) (Smith et al. 2011).","confidence":0.99853515625,"confidence_rate":0.9999747258765944},{"cnt":[[451,1409],[1687,1409],[1687,1450],[451,1450]],"region":{"top_left_x":451,"top_left_y":1409,"width":1236,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d388b00c168c467ab3deaec5d2fb138b","type":"text","conversion_output":true,"text":"While treatment of mild stroke is generally uncommon, leading stroke centers vary","text_display":"\n\nWhile treatment of mild stroke is generally uncommon, leading stroke centers vary","confidence":1,"confidence_rate":1},{"cnt":[[449,1457],[1794,1457],[1794,1497],[449,1497]],"region":{"top_left_x":449,"top_left_y":1456,"width":1345,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3be1ce49081475fbd9bbfd00291dc4a","type":"text","conversion_output":true,"text":"widely in their approach. For example, the proportion of mild stroke patients (NIHSS < 4)","text_display":" widely in their approach. For example, the proportion of mild stroke patients (NIHSS < 4)","confidence":0.9912109375,"confidence_rate":0.9999060904297419},{"cnt":[[451,1500],[1721,1500],[1721,1540],[451,1540]],"region":{"top_left_x":451,"top_left_y":1499,"width":1270,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"490be0b65498412194feb093e4d8eeb3","type":"text","conversion_output":true,"text":"treated with reperfusion therapies at National Institutes of Health/National Institute of","text_display":" treated with reperfusion therapies at National Institutes of Health/National Institute of","confidence":0.9970703125,"confidence_rate":0.9999687878548241},{"cnt":[[451,1547],[1687,1547],[1687,1588],[451,1588]],"region":{"top_left_x":451,"top_left_y":1546,"width":1236,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6e7bd4058d941d4b149e9ea5e7a57bd","type":"text","conversion_output":true,"text":"Neurological Disorders and Stroke (NINDS) Specialized Programs of Translational","text_display":" Neurological Disorders and Stroke (NINDS) Specialized Programs of Translational","confidence":1,"confidence_rate":1},{"cnt":[[451,1594],[1751,1594],[1751,1635],[451,1635]],"region":{"top_left_x":451,"top_left_y":1594,"width":1300,"height":41},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19eb29b5a5e948a2a216162a68240958","type":"text","conversion_output":true,"text":"Research in Acute Stroke (SPOTRIAS) centers ranged from 2\\% - 16\\% in 2008-2009","text_display":" Research in Acute Stroke (SPOTRIAS) centers ranged from 2\\% - 16\\% in 2008-2009","confidence":0.47271791732475443,"confidence_rate":0.9909043443995343},{"cnt":[[451,1641],[1704,1641],[1704,1682],[451,1682]],"region":{"top_left_x":451,"top_left_y":1641,"width":1253,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63a7b76909fa4a54a70a9378d754c433","type":"text","conversion_output":true,"text":"(Wiley et al. 2012). This variability in approach is also evident upon discussion with","text_display":" (Wiley et al. 2012). 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1","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1747,2428],[1788,2428],[1788,2471],[1747,2471]],"region":{"top_left_x":1746,"top_left_y":2427,"width":42,"height":44},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fc8161e312b4875b74c2e1e2ec245a3","type":"page_info","conversion_output":false,"text":"15","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9032a4edd7c4585a03d8a629934aa36","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9912373714710156,"confidence_rate":0.9998646053802442},{"cnt":[[374,2608],[692,2608],[692,2643],[374,2643]],"region":{"top_left_x":373,"top_left_y":2608,"width":319,"height":35},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbf48688e4874596bec483ff81cab7fd","type":"page_info","conversion_output":false,"text":"352/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-017","page":17,"lines":[{"cnt":[[451,374],[1611,374],[1611,419],[451,419]],"region":{"top_left_x":451,"top_left_y":373,"width":1161,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a59de3acee94f44b9ef1cbfa2e7a258","type":"text","conversion_output":true,"text":"Kinetic analyses suggest that plasminogen activation in the presence of fibrin","text_display":"\n\nKinetic analyses suggest that plasminogen activation in the presence of fibrin","confidence":1,"confidence_rate":1},{"cnt":[[449,421],[1775,421],[1775,466],[449,466]],"region":{"top_left_x":449,"top_left_y":421,"width":1326,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61f07cb7cf914a95a52cdeeeb159c81d","type":"text","conversion_output":true,"text":"occurs after the binding of plasminogen and t-PA at the clot site. t-PA has a high affinity","text_display":" occurs after the binding of plasminogen and t-PA at the clot site. t-PA has a high affinity","confidence":1,"confidence_rate":1},{"cnt":[[447,466],[1755,466],[1755,511],[447,511]],"region":{"top_left_x":446,"top_left_y":466,"width":1310,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f168511888814f8291dad8e6801ce0d2","type":"text","conversion_output":true,"text":"for fibrin, thereby efficiently activating the fibrin-bound plasminogen and converting it to","text_display":" for fibrin, thereby efficiently activating the fibrin-bound plasminogen and converting it to","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[449,511],[1712,511],[1712,559],[449,559]],"region":{"top_left_x":449,"top_left_y":511,"width":1264,"height":48},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53cbb7e8ed8f4bf688e78a4f5122f393","type":"text","conversion_output":true,"text":"plasmin. Plasmin, which when bound to fibrin is protected from rapid inactivation by","text_display":" plasmin. Plasmin, which when bound to fibrin is protected from rapid inactivation by","confidence":1,"confidence_rate":1},{"cnt":[[447,559],[1261,559],[1261,604],[447,604]],"region":{"top_left_x":446,"top_left_y":558,"width":816,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae7db8888ee041a7bdb28121eeebdbb8","type":"text","conversion_output":true,"text":"\\(\\alpha 2\\)-antiplasmin, then proceeds to digest the fibrin clot.","text_display":" \\(\\alpha 2\\)-antiplasmin, then proceeds to digest the fibrin clot.","confidence":1,"confidence_rate":1},{"cnt":[[449,642],[1777,642],[1777,690],[449,690]],"region":{"top_left_x":449,"top_left_y":642,"width":1328,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb1e1103f5da43d7887a18637aea76ec","type":"text","conversion_output":true,"text":"See the alteplase Investigator's Brochure for additional details on nonclinical and clinical","text_display":"\n\nSee the alteplase Investigator's Brochure for additional details on nonclinical and clinical","confidence":0.99267578125,"confidence_rate":0.9999242175878068},{"cnt":[[449,690],[574,690],[574,728],[449,728]],"region":{"top_left_x":449,"top_left_y":689,"width":125,"height":40},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb91653be9924f7caa2bec69a39a6c2d","type":"text","conversion_output":true,"text":"studies.","text_display":" studies.","confidence":1,"confidence_rate":1},{"cnt":[[443,752],[1656,752],[1656,819],[443,819]],"region":{"top_left_x":442,"top_left_y":751,"width":1215,"height":68},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc0cff543d1f44da8d94e752877a097d","type":"section_header","conversion_output":false,"children_ids":["49b380b78a45481fafa68435b5549ceb"],"text":"","text_display":""},{"cnt":[[449,761],[1652,761],[1652,810],[449,810]],"region":{"top_left_x":449,"top_left_y":760,"width":1204,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49b380b78a45481fafa68435b5549ceb","type":"text","conversion_output":true,"parent_id":"fc0cff543d1f44da8d94e752877a097d","text":"1.3 STUDY RATIONALE AND BENEFIT-RISK ASSESSMENT","text_display":"\n\n\\subsection*{1.3 STUDY RATIONALE AND BENEFIT-RISK ASSESSMENT}","confidence":0.99853515625,"confidence_rate":0.9999718096726914},{"cnt":[[447,829],[1742,829],[1742,874],[447,874]],"region":{"top_left_x":446,"top_left_y":829,"width":1297,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86784c97e2164123b3a9ff39515f2f1d","type":"text","conversion_output":true,"text":"Alteplase is the only approved therapeutic agent for the treatment of AIS and is widely","text_display":"\n\nAlteplase is the only approved therapeutic agent for the treatment of AIS and is widely","confidence":1,"confidence_rate":1},{"cnt":[[449,872],[1712,872],[1712,922],[449,922]],"region":{"top_left_x":449,"top_left_y":872,"width":1264,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48517e72d9c942afafe8183b6827800e","type":"text","conversion_output":true,"text":"accepted as the standard of care for eligible patients (Edlow et al. 2013; Jauch et al.","text_display":" accepted as the standard of care for eligible patients (Edlow et al. 2013; Jauch et al.","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[447,920],[1665,920],[1665,967],[447,967]],"region":{"top_left_x":446,"top_left_y":919,"width":1220,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09781853379c42888fab51fb52d98a9c","type":"text","conversion_output":true,"text":"2013). The currently approved Activase \\({ }^{\\text {® }}\\) (alteplase) U.S. Package Insert (USPI)","text_display":" 2013). The currently approved Activase \\({ }^{\\text {® }}\\) (alteplase) U.S. Package Insert (USPI)","confidence":0.90966796875,"confidence_rate":0.9990441377785483},{"cnt":[[449,967],[1687,967],[1687,1012],[449,1012]],"region":{"top_left_x":449,"top_left_y":966,"width":1238,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b72df28eff44b449cd68841ff5d043d","type":"text","conversion_output":true,"text":"contains wording that recommends against use of alteplase in patients with \"minor","text_display":" contains wording that recommends against use of alteplase in patients with \"minor","confidence":1,"confidence_rate":1},{"cnt":[[449,1014],[1790,1014],[1790,1059],[449,1059]],"region":{"top_left_x":449,"top_left_y":1014,"width":1341,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"091e8ac7acee4336afb4217a2c71d952","type":"text","conversion_output":true,"text":"neurological deficit or with rapidly improving stroke symptoms\" due to the fact this patient","text_display":" neurological deficit or with rapidly improving stroke symptoms\" due to the fact this patient","confidence":1,"confidence_rate":1},{"cnt":[[451,1059],[1618,1059],[1618,1106],[451,1106]],"region":{"top_left_x":451,"top_left_y":1059,"width":1167,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfe62209dd1b46c3ad83a591904c940a","type":"text","conversion_output":true,"text":"population has not been evaluated. Furthermore, the current American Heart","text_display":" population has not been evaluated. Furthermore, the current American Heart","confidence":1,"confidence_rate":1},{"cnt":[[449,1104],[1764,1104],[1764,1154],[449,1154]],"region":{"top_left_x":449,"top_left_y":1104,"width":1315,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaeac76dc42e448ab13098d1ef42b810","type":"text","conversion_output":true,"text":"Association/American Stroke Association Council Guidelines include \"minor and rapidly","text_display":" Association/American Stroke Association Council Guidelines include \"minor and rapidly","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[449,1152],[1777,1152],[1777,1197],[449,1197]],"region":{"top_left_x":449,"top_left_y":1151,"width":1328,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af48d71a9b2a462792a3330c2b4fb3ec","type":"text","conversion_output":true,"text":"improving stroke symptoms (clearing spontaneously)\" as a relative exclusion criterion for","text_display":" improving stroke symptoms (clearing spontaneously)\" as a relative exclusion criterion for","confidence":1,"confidence_rate":1},{"cnt":[[451,1199],[1738,1199],[1738,1244],[451,1244]],"region":{"top_left_x":451,"top_left_y":1198,"width":1288,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45a69116e3544019a897d8a7bf9e4db2","type":"text","conversion_output":true,"text":"alteplase (Jauch, et al. 2013). This is largely due to the aforementioned label wording","text_display":" alteplase (Jauch, et al. 2013). This is largely due to the aforementioned label wording","confidence":1,"confidence_rate":1},{"cnt":[[451,1244],[1729,1244],[1729,1291],[451,1291]],"region":{"top_left_x":451,"top_left_y":1243,"width":1279,"height":49},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8342c892caf43f4a77ee47714fdc1b6","type":"text","conversion_output":true,"text":"not recommending treatment of patients with minor neurological deficit or with rapidly","text_display":" not recommending treatment of patients with minor neurological deficit or with rapidly","confidence":1,"confidence_rate":1},{"cnt":[[451,1289],[1772,1289],[1772,1336],[451,1336]],"region":{"top_left_x":451,"top_left_y":1289,"width":1322,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97a47f3434174022af9090b8a6363d29","type":"text","conversion_output":true,"text":"improving stroke symptoms (RISS), the lack of a consistent and consensus definition on","text_display":" improving stroke symptoms (RISS), the lack of a consistent and consensus definition on","confidence":1,"confidence_rate":1},{"cnt":[[449,1336],[1665,1336],[1665,1381],[449,1381]],"region":{"top_left_x":449,"top_left_y":1336,"width":1217,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ea40824382d490784900844c5a9ffb4","type":"text","conversion_output":true,"text":"who constitutes this patient population, and the absence of definitive evidence of","text_display":" who constitutes this patient population, and the absence of definitive evidence of","confidence":0.96826171875,"confidence_rate":0.999629346207491},{"cnt":[[449,1384],[1676,1384],[1676,1429],[449,1429]],"region":{"top_left_x":449,"top_left_y":1383,"width":1227,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0387fb6843e6443f988722087aed13f4","type":"text","conversion_output":true,"text":"alteplase efficacy in this setting (TREAT Task Force 2013). Therefore, this trial is","text_display":" alteplase efficacy in this setting (TREAT Task Force 2013). Therefore, this trial is","confidence":1,"confidence_rate":1},{"cnt":[[449,1429],[1755,1429],[1755,1476],[449,1476]],"region":{"top_left_x":449,"top_left_y":1428,"width":1307,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e9b400ce8004db6aed08c3faf8827bb","type":"text","conversion_output":true,"text":"designed to evaluate the efficacy and safety of alteplase in confirmed AIS patients with","text_display":" designed to evaluate the efficacy and safety of alteplase in confirmed AIS patients with","confidence":1,"confidence_rate":1},{"cnt":[[451,1474],[1704,1474],[1704,1519],[451,1519]],"region":{"top_left_x":451,"top_left_y":1473,"width":1253,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e93fa2cb16e45b39a69fecfa11a2b34","type":"text","conversion_output":true,"text":"minor neurological deficit or with RISS, which will be referred to collectively as \"mild","text_display":" minor neurological deficit or with RISS, which will be referred to collectively as \"mild","confidence":1,"confidence_rate":1},{"cnt":[[451,1521],[930,1521],[930,1566],[451,1566]],"region":{"top_left_x":451,"top_left_y":1521,"width":480,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89ed241c31b44f9584bdd0019e3458f5","type":"text","conversion_output":true,"text":"stroke\" throughout the protocol.","text_display":" stroke\" throughout the protocol.","confidence":1,"confidence_rate":1},{"cnt":[[449,1605],[1772,1605],[1772,1652],[449,1652]],"region":{"top_left_x":449,"top_left_y":1604,"width":1324,"height":49},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b6c9d331f8b407392c4857d277cb8b8","type":"text","conversion_output":true,"text":"To date, all completed major randomized acute stroke trials have excluded patients with","text_display":"\n\nTo date, all completed major randomized acute stroke trials have excluded patients with","confidence":1,"confidence_rate":1},{"cnt":[[449,1652],[1742,1652],[1742,1695],[449,1695]],"region":{"top_left_x":449,"top_left_y":1652,"width":1294,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9aa6bb040c844d6a7cd6c931ee46f7e","type":"text","conversion_output":true,"text":"mild strokes to varying degrees. In the two NINDS trials, such patients were excluded","text_display":" mild strokes to varying degrees. In the two NINDS trials, such patients were excluded","confidence":1,"confidence_rate":1},{"cnt":[[449,1697],[1781,1697],[1781,1742],[449,1742]],"region":{"top_left_x":449,"top_left_y":1697,"width":1333,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f830283b41944a46a947d5b1619c24fe","type":"text","conversion_output":true,"text":"according to the protocol (largely to prevent patients with transient ischemic attacks from","text_display":" according to the protocol (largely to prevent patients with transient ischemic attacks from","confidence":1,"confidence_rate":1},{"cnt":[[451,1745],[1742,1745],[1742,1790],[451,1790]],"region":{"top_left_x":451,"top_left_y":1744,"width":1292,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"283a59b1205f4b7088c629550fe2dbe2","type":"text","conversion_output":true,"text":"being enrolled if they were having rapidly improving symptoms), but did not include an","text_display":" being enrolled if they were having rapidly improving symptoms), but did not include an","confidence":1,"confidence_rate":1},{"cnt":[[451,1790],[1751,1790],[1751,1835],[451,1835]],"region":{"top_left_x":451,"top_left_y":1789,"width":1300,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"648a21b3ece24f59ad34c7e1196213fe","type":"text","conversion_output":true,"text":"explicit definition of mild stroke except for pure sensory stroke, isolated ataxia, isolated","text_display":" explicit definition of mild stroke except for pure sensory stroke, isolated ataxia, isolated","confidence":1,"confidence_rate":1},{"cnt":[[451,1835],[1652,1835],[1652,1880],[451,1880]],"region":{"top_left_x":451,"top_left_y":1834,"width":1202,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5c5f09af49642799d77e5f5fec788be","type":"text","conversion_output":true,"text":"dysarthria, and isolated facial weakness (NINDS rt-PA Study Group 1995). The","text_display":" dysarthria, and isolated facial weakness (NINDS rt-PA Study Group 1995). The","confidence":1,"confidence_rate":1},{"cnt":[[449,1882],[1734,1882],[1734,1927],[449,1927]],"region":{"top_left_x":449,"top_left_y":1882,"width":1285,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ef4a45dad9e437a90a6e81b28205ad4","type":"text","conversion_output":true,"text":"operational definition for stroke symptoms too mild to treat was left to the judgment of","text_display":" operational definition for stroke symptoms too mild to treat was left to the judgment of","confidence":1,"confidence_rate":1},{"cnt":[[449,1929],[1772,1929],[1772,1974],[449,1974]],"region":{"top_left_x":449,"top_left_y":1929,"width":1324,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f82850df0ef943199e44a169514190fe","type":"text","conversion_output":true,"text":"the randomizing physician (TREAT Task Force 2013). Interestingly, a post hoc analysis","text_display":" the randomizing physician (TREAT Task Force 2013). Interestingly, a post hoc analysis","confidence":1,"confidence_rate":1},{"cnt":[[449,1972],[1768,1972],[1768,2020],[449,2020]],"region":{"top_left_x":449,"top_left_y":1972,"width":1320,"height":48},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87b30f9538ea4fed90a6486209d7fe90","type":"text","conversion_output":true,"text":"of the 624 patients in the NINDS trial revealed that there were 58 patients ( \\(9 \\%\\) ) enrolled","text_display":" of the 624 patients in the NINDS trial revealed that there were 58 patients ( \\(9 \\%\\) ) enrolled","confidence":0.9551627328619361,"confidence_rate":0.9995632044504359},{"cnt":[[449,2020],[1734,2020],[1734,2065],[449,2065]],"region":{"top_left_x":449,"top_left_y":2019,"width":1285,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26d2705038db4c338b2a85071686da9d","type":"text","conversion_output":true,"text":"with an NIHSS score \\(\\leq 5\\), none of whom had isolated motor symptoms, isolated facial","text_display":" with an NIHSS score \\(\\leq 5\\), none of whom had isolated motor symptoms, isolated facial","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[449,2067],[1665,2067],[1665,2112],[449,2112]],"region":{"top_left_x":449,"top_left_y":2066,"width":1217,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ad8c5c203b74b2da3d0618dedd2ce44","type":"text","conversion_output":true,"text":"droop, isolated ataxia, dysarthria, isolated sensory, and three or fewer of each of","text_display":" droop, isolated ataxia, dysarthria, isolated sensory, and three or fewer of each of","confidence":1,"confidence_rate":1},{"cnt":[[449,2110],[1779,2110],[1779,2157],[449,2157]],"region":{"top_left_x":449,"top_left_y":2109,"width":1330,"height":49},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2635f5dc9d0044bfb298a804bfde8be0","type":"text","conversion_output":true,"text":"additional isolated deficits (Khatri et al. 2010). Perhaps more significantly, 2971 patients","text_display":" additional isolated deficits (Khatri et al. 2010). Perhaps more significantly, 2971 patients","confidence":1,"confidence_rate":1},{"cnt":[[449,2159],[1723,2159],[1723,2204],[449,2204]],"region":{"top_left_x":449,"top_left_y":2159,"width":1275,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80a299eef6594011a85cbdad18b9bbf5","type":"text","conversion_output":true,"text":"were excluded primarily due to \"rapidly improving\" or \"minor symptoms.\" However, a","text_display":" were excluded primarily due to \"rapidly improving\" or \"minor symptoms.\" However, a","confidence":1,"confidence_rate":1},{"cnt":[[451,2204],[1742,2204],[1742,2249],[451,2249]],"region":{"top_left_x":451,"top_left_y":2204,"width":1292,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11cfdc02cd1d480a87b61028868cc774","type":"text","conversion_output":true,"text":"significant unmet medical need exists for patients with mild stroke. Available outcome","text_display":" significant unmet medical need exists for patients with mild stroke. Available outcome","confidence":1,"confidence_rate":1},{"cnt":[[451,2252],[1764,2252],[1764,2297],[451,2297]],"region":{"top_left_x":451,"top_left_y":2251,"width":1313,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c55d218b1a8c4711b18d453cb0d690fe","type":"text","conversion_output":true,"text":"data for patients with mild stroke who do not receive alteplase consistently demonstrate","text_display":" data for patients with mild stroke who do not receive alteplase consistently demonstrate","confidence":1,"confidence_rate":1},{"cnt":[[451,2299],[1768,2299],[1768,2344],[451,2344]],"region":{"top_left_x":451,"top_left_y":2298,"width":1318,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2d584a186044555bed99781ba0797bf","type":"text","conversion_output":true,"text":"a high rate of suboptimal outcomes. 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Post hoc analyses, case series, and retrospective studies in patients with mild","text_display":" (sICH). 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No data exist to estimate the sICH rate for patients with","text_display":" of sICH risk (Khatri et al. 2007). No data exist to estimate the sICH rate for patients with","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[451,1697],[1745,1697],[1745,1740],[451,1740]],"region":{"top_left_x":451,"top_left_y":1697,"width":1294,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"505dfb2e161d4feb98925e30b1757a60","type":"text","conversion_output":true,"text":"mild stroke who did not receive t-PA; therefore, for this study, we are using a \\(0 \\%\\) sICH","text_display":" mild stroke who did not receive t-PA; therefore, for this study, we are using a \\(0 \\%\\) sICH","confidence":0.9941432476043701,"confidence_rate":0.9999381706438218},{"cnt":[[451,1740],[1697,1740],[1697,1785],[451,1785]],"region":{"top_left_x":451,"top_left_y":1740,"width":1247,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb5807e893ea42da958b46d36f6e58c5","type":"text","conversion_output":true,"text":"rate for the placebo arm, which is likely a conservative estimate. An absolute sICH","text_display":" rate for the placebo arm, which is likely a conservative estimate. 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For this study, sICH","text_display":" alteplase arm vs. the placebo control arm in the proposed study. 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Assuming a \\(2 \\%\\) absolute difference in sICH rate in patients treated","text_display":" for one patient is 11 . 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The actual number NNH, or","text_display":" specifically for sICH, is conservatively estimated to be 50 . 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The trial will consist of a screening assessment,","text_display":" do not appear to be clearly disabling. 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Patients meeting","text_display":"\n\nScreening assessments will determine the eligibility of the patient. Patients meeting","confidence":1,"confidence_rate":1},{"cnt":[[451,2157],[1659,2157],[1659,2198],[451,2198]],"region":{"top_left_x":451,"top_left_y":2157,"width":1208,"height":41},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b6ef2ac92c24bce844f3bb6d37e5855","type":"text","conversion_output":true,"text":"eligibility criteria will be randomized in a 1:1 ratio to receive either 1) one dose of","text_display":" eligibility criteria will be randomized in a 1:1 ratio to receive either 1) one dose of","confidence":0.58154296875,"confidence_rate":0.9941252544532525},{"cnt":[[451,2202],[1779,2202],[1779,2243],[451,2243]],"region":{"top_left_x":451,"top_left_y":2202,"width":1328,"height":41},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b95fb80da574d6e9b2088f9e4744574","type":"text","conversion_output":true,"text":"alteplase \\(0.9 mg / kg\\) IV (not to exceed 90 mg ) and one dose of oral aspirin placebo 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1","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2428],[1788,2428],[1788,2471],[1749,2471]],"region":{"top_left_x":1748,"top_left_y":2427,"width":40,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3759080fb66b4f4b9e4559ca8fdc3f8e","type":"page_info","conversion_output":false,"text":"19","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[372,2574],[1416,2574],[1416,2615],[372,2615]],"region":{"top_left_x":371,"top_left_y":2573,"width":1045,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b22bb07992e4b35996c2eec1bead423","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, 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A \"step forward\" randomization regimen stratified by site will be","text_display":" in the treatment groups. 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The primary endpoint using the mRS assessment of global disability at","text_display":" institutions. 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occur in otherwise eligible AIS patients","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[516,937],[1184,937],[1184,973],[516,973]],"region":{"top_left_x":515,"top_left_y":936,"width":669,"height":38},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b49a5347fed54fea9dbb3d15d3009abd","type":"text","conversion_output":true,"text":"within 3 hours from the last known well time.","text_display":" within 3 hours from the last known well time.","confidence":1,"confidence_rate":1},{"cnt":[[451,997],[1755,997],[1755,1038],[451,1038]],"region":{"top_left_x":451,"top_left_y":996,"width":1305,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e4a8b495cd04b21a270dcc21fa64b56","type":"text","conversion_output":true,"text":"- Conduct of a large, multicenter study: The Sponsor plans to enroll 948 patients","text_display":"\n- Conduct of a large, multicenter study: The Sponsor plans to enroll 948 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NIHSS score \\(\\leq 5\\) was chosen as one criterion in the definition of mild stroke for","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[449,421],[973,421],[973,466],[449,466]],"region":{"top_left_x":449,"top_left_y":421,"width":525,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32802e6ede4542e48cfc283629c71582","type":"text","conversion_output":true,"text":"PRISMS for the following reasons:","text_display":" PRISMS for the following reasons:","confidence":1,"confidence_rate":1},{"cnt":[[449,477],[1729,477],[1729,522],[449,522]],"region":{"top_left_x":449,"top_left_y":476,"width":1281,"height":47},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a63f19b69e9482e8ebfb2d4deffb0ba","type":"text","conversion_output":true,"text":"1. 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However, PRISMS combines these two","confidence":1,"confidence_rate":1},{"cnt":[[451,468],[1772,468],[1772,511],[451,511]],"region":{"top_left_x":451,"top_left_y":468,"width":1322,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dc906bb24c741aa8a6ce196a3bf1c9a","type":"text","conversion_output":true,"text":"patient groups into one operationally defined patient population (mild stroke): all eligible","text_display":" patient groups into one operationally defined patient population (mild stroke): all eligible","confidence":1,"confidence_rate":1},{"cnt":[[451,511],[1738,511],[1738,559],[451,559]],"region":{"top_left_x":451,"top_left_y":511,"width":1288,"height":48},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"175c8eac9f5d472eae5913d7518fd4cb","type":"text","conversion_output":true,"text":"patients with an NIHSS score \\(\\leq 5\\) at the time of randomization without clearly disabling","text_display":" patients with an NIHSS score \\(\\leq 5\\) at the time of randomization without clearly disabling","confidence":0.9834063053131104,"confidence_rate":0.999822006137716},{"cnt":[[451,559],[1729,559],[1729,604],[451,604]],"region":{"top_left_x":451,"top_left_y":558,"width":1279,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec27c5923fb5479abde51e047de78628","type":"text","conversion_output":true,"text":"symptoms, irrespective of previous NIHSS scores. Data demonstrating low alteplase","text_display":" symptoms, irrespective of previous NIHSS scores. Data demonstrating low alteplase","confidence":1,"confidence_rate":1},{"cnt":[[451,606],[1747,606],[1747,649],[451,649]],"region":{"top_left_x":451,"top_left_y":605,"width":1296,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36ce501c5bb240da82e172b8aab9d9b1","type":"text","conversion_output":true,"text":"use in patients with NIHSS scores \\(\\leq 5\\) do not distinguish between whether the patient's","text_display":" use in patients with NIHSS scores \\(\\leq 5\\) do not distinguish between whether the patient's","confidence":0.9990234375,"confidence_rate":0.9999894942525209},{"cnt":[[451,649],[1764,649],[1764,696],[451,696]],"region":{"top_left_x":451,"top_left_y":648,"width":1313,"height":49},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cd3adbbca2244a88aacc645378b351b","type":"text","conversion_output":true,"text":"deficit was persistently mild or improved to this status (Smith et al. 2011). Furthermore,","text_display":" deficit was persistently mild or improved to this status (Smith et al. 2011). Furthermore,","confidence":0.998046875,"confidence_rate":0.9999794208976915},{"cnt":[[451,696],[1790,696],[1790,741],[451,741]],"region":{"top_left_x":451,"top_left_y":696,"width":1339,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52909886f0b54737a1722dae27a47856","type":"text","conversion_output":true,"text":"no data exist that suggest patients who improved to a mild status at the time of treatment","text_display":" no data exist that suggest patients who improved to a mild status at the time of treatment","confidence":1,"confidence_rate":1},{"cnt":[[449,743],[1644,743],[1644,788],[449,788]],"region":{"top_left_x":449,"top_left_y":743,"width":1195,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7509a9b1920b4987a4455e14cbb27501","type":"text","conversion_output":true,"text":"with alteplase have different outcomes from patients whose neurologic deficit is","text_display":" with alteplase have different outcomes from patients whose neurologic deficit is","confidence":1,"confidence_rate":1},{"cnt":[[451,786],[1631,786],[1631,836],[451,836]],"region":{"top_left_x":451,"top_left_y":786,"width":1180,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"079fa101dadc435e931f5d3dc11a76b2","type":"text","conversion_output":true,"text":"persistently mild. To date, available data suggest that alteplase therapy would","text_display":" persistently mild. To date, available data suggest that alteplase therapy would","confidence":1,"confidence_rate":1},{"cnt":[[451,834],[1747,834],[1747,879],[451,879]],"region":{"top_left_x":451,"top_left_y":833,"width":1296,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f2f79f1aa7c44318b22537d3643c5f2","type":"text","conversion_output":true,"text":"potentially be beneficial in both patients with RISS who improve to an NIHSS score \\(\\leq 5\\)","text_display":" potentially be beneficial in both patients with RISS who improve to an NIHSS score \\(\\leq 5\\)","confidence":0.9921910762786865,"confidence_rate":0.9999119187891624},{"cnt":[[449,881],[1506,881],[1506,926],[449,926]],"region":{"top_left_x":449,"top_left_y":880,"width":1058,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9f015c26ad749aea33fb4a817f7e0ed","type":"text","conversion_output":true,"text":"and patients with persistently mild symptoms with an NIHSS score \\(\\leq 5\\).","text_display":" and patients with persistently mild symptoms with an NIHSS score \\(\\leq 5\\).","confidence":0.99951171875,"confidence_rate":0.9999936571565041},{"cnt":[[451,967],[1663,967],[1663,1010],[451,1010]],"region":{"top_left_x":451,"top_left_y":966,"width":1212,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96174dd8699d4a47ba5fabcf9e5e2d42","type":"text","conversion_output":true,"text":"Conversely, patients who improve to an NIHSS score > 5 at the time of treatment","text_display":"\n\nConversely, patients who improve to an NIHSS score > 5 at the time of treatment","confidence":0.46344371914847216,"confidence_rate":0.9911990681233303},{"cnt":[[449,1010],[1674,1010],[1674,1057],[449,1057]],"region":{"top_left_x":449,"top_left_y":1009,"width":1225,"height":49},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4a6f4d2932d4722a2408a8768a608b0","type":"text","conversion_output":true,"text":"decision will be excluded from PRISMS as they are not considered to have RISS.","text_display":" decision will be excluded from PRISMS as they are not considered to have RISS.","confidence":1,"confidence_rate":1},{"cnt":[[451,1057],[1704,1057],[1704,1102],[451,1102]],"region":{"top_left_x":451,"top_left_y":1057,"width":1253,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b79a18d62ae8474fb9af0e6cfb4a391d","type":"text","conversion_output":true,"text":"Current clinical practice suggests that these patients would still have a moderate or","text_display":" Current clinical practice suggests that these patients would still have a moderate or","confidence":1,"confidence_rate":1},{"cnt":[[451,1104],[1751,1104],[1751,1149],[451,1149]],"region":{"top_left_x":451,"top_left_y":1104,"width":1300,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c057effaa244826affcb0bbd6da2239","type":"text","conversion_output":true,"text":"severe stroke at the time of treatment decision and should receive alteplase, if eligible,","text_display":" severe stroke at the time of treatment decision and should receive alteplase, if eligible,","confidence":1,"confidence_rate":1},{"cnt":[[451,1152],[1734,1152],[1734,1197],[451,1197]],"region":{"top_left_x":451,"top_left_y":1151,"width":1283,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64942ef392f247e8a4f447b1471ef136","type":"text","conversion_output":true,"text":"rather than be randomized to a study. Such patients should not be defined as rapidly","text_display":" rather than be randomized to a study. Such patients should not be defined as rapidly","confidence":1,"confidence_rate":1},{"cnt":[[451,1197],[1729,1197],[1729,1240],[451,1240]],"region":{"top_left_x":451,"top_left_y":1196,"width":1279,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83e2ba7635494119bbd09414060771e3","type":"text","conversion_output":true,"text":"improving, given that they have not improved to an NIHSS score low enough to merit","text_display":" improving, given that they have not improved to an NIHSS score low enough to merit","confidence":1,"confidence_rate":1},{"cnt":[[449,1242],[1682,1242],[1682,1287],[449,1287]],"region":{"top_left_x":449,"top_left_y":1241,"width":1234,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a20d0baa4ef4430f9dcd00d0c3cea673","type":"text","conversion_output":true,"text":"withholding therapy. This definition of RISS is consistent with a recent consensus","text_display":" withholding therapy. This definition of RISS is consistent with a recent consensus","confidence":1,"confidence_rate":1},{"cnt":[[451,1289],[1691,1289],[1691,1334],[451,1334]],"region":{"top_left_x":451,"top_left_y":1289,"width":1240,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c6b7b9d33a64920b8422b4eab25b108","type":"text","conversion_output":true,"text":"statement by leading stroke and emergency medicine experts (TREAT Task Force","text_display":" statement by leading stroke and emergency medicine experts (TREAT Task Force","confidence":1,"confidence_rate":1},{"cnt":[[451,1336],[552,1336],[552,1379],[451,1379]],"region":{"top_left_x":451,"top_left_y":1336,"width":102,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59c0831c9167458b9a2699c0cd387121","type":"text","conversion_output":true,"text":"2013).","text_display":" 2013).","confidence":1,"confidence_rate":1},{"cnt":[[451,1418],[1708,1418],[1708,1463],[451,1463]],"region":{"top_left_x":451,"top_left_y":1417,"width":1258,"height":47},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47eef07af8b54dda844566b0d813fb0e","type":"text","conversion_output":true,"text":"PRISMS will also exclude patients who are assessed at the time of pre-treatment to","text_display":"\n\nPRISMS will also exclude patients who are assessed at the time of pre-treatment to","confidence":0.99462890625,"confidence_rate":0.999938098813284},{"cnt":[[451,1465],[1781,1465],[1781,1510],[451,1510]],"region":{"top_left_x":451,"top_left_y":1465,"width":1331,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7b871e2df8f40a0b62bd5179da6b7b1","type":"text","conversion_output":true,"text":"likely be clearly disabled at 90 days, as defined by specific criteria described in the study","text_display":" likely be clearly disabled at 90 days, as defined by specific criteria described in the study","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[451,1512],[1712,1512],[1712,1558],[451,1558]],"region":{"top_left_x":451,"top_left_y":1512,"width":1262,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fed3d04e634486d9810b62d1aa49a73","type":"text","conversion_output":true,"text":"protocol. These deficits at presentation include, but are not limited to, homonymous","text_display":" protocol. 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90","confidence":0.96142578125,"confidence_rate":0.9995771011940128},{"cnt":[[518,589],[810,589],[810,625],[518,625]],"region":{"top_left_x":517,"top_left_y":588,"width":293,"height":38},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c531bd7ca644144a9853b3896add82d","type":"text","conversion_output":true,"text":"post-randomization","text_display":" post-randomization","confidence":1,"confidence_rate":1},{"cnt":[[516,645],[1669,645],[1669,685],[516,685]],"region":{"top_left_x":515,"top_left_y":644,"width":1155,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"652d495a416146d088bb4b86731fa82a","type":"text","conversion_output":true,"text":"- All mRS assessments will be made by investigators blinded to treatment","text_display":"\n- All mRS assessments will be made by investigators blinded to 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90 and listed below:","confidence":1,"confidence_rate":1},{"cnt":[[451,827],[956,827],[956,866],[451,866]],"region":{"top_left_x":451,"top_left_y":827,"width":506,"height":39},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d49aeec3b73f491f94e81569c2c35864","type":"text","conversion_output":true,"text":"- Ordinal improvement in mRS","text_display":"\n- Ordinal improvement in mRS","confidence":0.79296875,"confidence_rate":0.9929952103657839},{"cnt":[[451,885],[1308,885],[1308,924],[451,924]],"region":{"top_left_x":451,"top_left_y":885,"width":858,"height":39},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa1c4a32c3494cc2ade835c15dd0aa93","type":"text","conversion_output":true,"text":"- Neurological outcome (as measured by NIHSS 0-1)","text_display":"\n- Neurological outcome (as measured by NIHSS 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baseline and any","confidence":0.9990234375,"confidence_rate":0.9999879378548738},{"cnt":[[451,1886],[1727,1886],[1727,1927],[451,1927]],"region":{"top_left_x":451,"top_left_y":1886,"width":1277,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"384652e8c61e4ef3b60780edba526f7f","type":"text","conversion_output":true,"text":"neurologic decline is attributed to it by the local investigator. To detect asymptomatic","text_display":" neurologic decline is attributed to it by the local investigator. To detect asymptomatic","confidence":1,"confidence_rate":1},{"cnt":[[451,1934],[1717,1934],[1717,1972],[451,1972]],"region":{"top_left_x":451,"top_left_y":1933,"width":1266,"height":40},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"995b52bf8d4842bca982899c4e202f91","type":"text","conversion_output":true,"text":"intracranial hemorrhage, CT scan is required at 22 to 36 hours. Additional CT scans","text_display":" intracranial hemorrhage, CT scan is required at 22 to 36 hours. Additional CT scans","confidence":1,"confidence_rate":1},{"cnt":[[451,1981],[1682,1981],[1682,2017],[451,2017]],"region":{"top_left_x":451,"top_left_y":1980,"width":1232,"height":38},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c345a5be58a047b4861ce8086ab07da8","type":"text","conversion_output":true,"text":"should be performed at any time based on the investigator's discretion that clinical","text_display":" should be performed at any time based on the investigator's discretion that clinical","confidence":1,"confidence_rate":1},{"cnt":[[451,2024],[1704,2024],[1704,2065],[451,2065]],"region":{"top_left_x":451,"top_left_y":2023,"width":1253,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77f90f55c4e54503bf454bd833622a40","type":"text","conversion_output":true,"text":"findings suggested hemorrhage. An MRI may be substituted for CT per institutional","text_display":" findings suggested hemorrhage. An MRI may be substituted for CT per institutional","confidence":1,"confidence_rate":1},{"cnt":[[451,2071],[1407,2071],[1407,2110],[451,2110]],"region":{"top_left_x":451,"top_left_y":2071,"width":957,"height":39},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d733dded43a46ffb22972d4dcd390cf","type":"text","conversion_output":true,"text":"protocol. Details on MRI types are described in Section 4.5.1.6.","text_display":" protocol. 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Descriptions","text_display":" subarachnoid hemorrhage, subdural hemorrhage, or epidural hemorrhage. 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Remote primary intracerebral hemorrhage \\\\\n\\hline rPH type 2 & Large confluent dense blood clots in an area remote from the actual infarct; substantial space-occupying effect might be present. 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Remote primary","text_display":" mild space-occupying effect could be present. 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space-occupying effect might be present.","text_display":" substantial space-occupying effect might be present.","confidence":1,"confidence_rate":1},{"cnt":[[464,1033],[1742,1033],[1742,1072],[464,1072]],"region":{"top_left_x":464,"top_left_y":1033,"width":1279,"height":40},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db39692a8d5f4e2aad23ceb759c63837","type":"text","conversion_output":true,"text":"\\(HI =\\) hemorrhagic infarct; \\(PH =\\) parenchymal hematoma; rPH=remote parenchymal hematoma.","text_display":"\n\\(HI =\\) hemorrhagic infarct; \\(PH =\\) parenchymal hematoma; rPH=remote parenchymal 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Measures}","confidence":0.99853515625,"confidence_rate":0.9999624130735217},{"cnt":[[451,1212],[1414,1212],[1414,1253],[451,1253]],"region":{"top_left_x":451,"top_left_y":1211,"width":963,"height":42},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0289109670fe435e8609c7723432e472","type":"text","conversion_output":true,"text":"The exploratory outcome measures for this study are as follows:","text_display":"\n\nThe exploratory outcome measures for this study are as follows:","confidence":0.99951171875,"confidence_rate":0.9999928176655267},{"cnt":[[451,1268],[1412,1268],[1412,1313],[451,1313]],"region":{"top_left_x":451,"top_left_y":1267,"width":961,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5123b1458f7d4f1c8583a308e44ff6ad","type":"text","conversion_output":true,"text":"- Stroke recurrence (based on AE monitoring) within 90 days","text_display":"\n- Stroke recurrence (based on AE monitoring) within 90 days","confidence":1,"confidence_rate":1},{"cnt":[[451,1328],[1768,1328],[1768,1369],[451,1369]],"region":{"top_left_x":451,"top_left_y":1327,"width":1318,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3f4c469547d4fad8ab61ae86b7c586a","type":"text","conversion_output":true,"text":"- Cognition ( 30 -minute assessment: animal naming, controlled oral word association","text_display":"\n- Cognition ( 30 -minute assessment: animal naming, controlled oral word association","confidence":0.7373046875,"confidence_rate":0.9966929363303622},{"cnt":[[516,1371],[1777,1371],[1777,1412],[516,1412]],"region":{"top_left_x":515,"top_left_y":1370,"width":1262,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a0cf3475cff412b8608e9eeba61ca75","type":"text","conversion_output":true,"text":"test, digit symbol coding from the Wechsler Adult Intelligence Scale, Hopkins Verbal","text_display":" test, digit symbol coding from the Wechsler Adult Intelligence Scale, Hopkins Verbal","confidence":1,"confidence_rate":1},{"cnt":[[516,1414],[1768,1414],[1768,1454],[516,1454]],"region":{"top_left_x":515,"top_left_y":1413,"width":1254,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7ab04699cac4d7db14b774c317a9ba8","type":"text","conversion_output":true,"text":"Learning Test, 15 -item Boston Naming Test, forward and backward Digit Span test,","text_display":" Learning Test, 15 -item Boston Naming Test, forward and backward Digit Span test,","confidence":0.990234375,"confidence_rate":0.9998897406694751},{"cnt":[[516,1457],[1287,1457],[1287,1500],[516,1500]],"region":{"top_left_x":515,"top_left_y":1456,"width":772,"height":44},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebc1f16afb5d4710ba68285e01222b82","type":"text","conversion_output":true,"text":"and Rey-Osterreith Complex Figure test) at Day 90","text_display":" and 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expeditious manner that also ensures even distribution","confidence":1,"confidence_rate":1},{"cnt":[[451,1210],[1742,1210],[1742,1250],[451,1250]],"region":{"top_left_x":451,"top_left_y":1209,"width":1292,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e40d08bc81ed4648a4d1daffe1ecb0fb","type":"text","conversion_output":true,"text":"in the treatment groups. A step forward randomization regimen will be used to ensure","text_display":" in the treatment groups. A step forward randomization regimen will be used to ensure","confidence":1,"confidence_rate":1},{"cnt":[[451,1255],[1781,1255],[1781,1296],[451,1296]],"region":{"top_left_x":451,"top_left_y":1254,"width":1331,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b9f6d7cb28a4709bfef36f910cb4723","type":"text","conversion_output":true,"text":"that a randomized treatment assignment is available upon patients' arrival at the hospital","text_display":" that a randomized treatment assignment is available upon patients' arrival at the hospital","confidence":1,"confidence_rate":1},{"cnt":[[451,1302],[1755,1302],[1755,1343],[451,1343]],"region":{"top_left_x":451,"top_left_y":1301,"width":1305,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28cc1e4ef91f4cfda612f450c7e6de34","type":"text","conversion_output":true,"text":"and treatment can initiate immediately upon signing the informed consent and eligibility","text_display":" and treatment can initiate immediately upon signing the informed consent and eligibility","confidence":1,"confidence_rate":1},{"cnt":[[451,1349],[1678,1349],[1678,1390],[451,1390]],"region":{"top_left_x":451,"top_left_y":1349,"width":1227,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34aa160696ab409398581fa03f31694a","type":"text","conversion_output":true,"text":"confirmation. 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IxRS will assign a patient ID to the currently treated patient, which will be correlated","text_display":"\n1. 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patient.","text_display":" activation, which will assign drug kit IDs ahead of time for the first potential patient.","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[451,782],[1794,782],[1794,827],[451,827]],"region":{"top_left_x":451,"top_left_y":782,"width":1343,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b964d94b4c8547f9a499a4f334e7860f","type":"text","conversion_output":true,"text":"Once the first patient is enrolled at a site, the procedure described above will commence.","text_display":" Once the first patient is enrolled at a site, the procedure described above will 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that a patient worsens (e.g., to a moderate or severe","confidence":1,"confidence_rate":1},{"cnt":[[451,1130],[1772,1130],[1772,1175],[451,1175]],"region":{"top_left_x":451,"top_left_y":1130,"width":1322,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2baa758c14094c21a81e3fda5612b236","type":"text","conversion_output":true,"text":"stroke) from time of study treatment and the patient remains within a time window within","text_display":" stroke) from time of study treatment and the patient remains within a time window within","confidence":1,"confidence_rate":1},{"cnt":[[451,1177],[1755,1177],[1755,1222],[451,1222]],"region":{"top_left_x":451,"top_left_y":1177,"width":1305,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6495a42989b4930aeb5ed9b16a50da3","type":"text","conversion_output":true,"text":"institutional guidelines to initiate thrombolytic therapy, the investigator has the option to","text_display":" institutional guidelines to initiate thrombolytic therapy, the investigator has the option to","confidence":1,"confidence_rate":1},{"cnt":[[451,1225],[1729,1225],[1729,1268],[451,1268]],"region":{"top_left_x":451,"top_left_y":1224,"width":1279,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"016788e65ade4fb0ab3551a3df3e4dbb","type":"text","conversion_output":true,"text":"unblind the treatment to ensure the patient receives appropriate treatment. However,","text_display":" unblind the treatment to ensure the patient receives appropriate treatment. However,","confidence":1,"confidence_rate":1},{"cnt":[[451,1272],[1240,1272],[1240,1315],[451,1315]],"region":{"top_left_x":451,"top_left_y":1271,"width":789,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65a59d59107245f5b269f64f616e92c8","type":"text","conversion_output":true,"text":"the following criteria must be met prior to unblinding:","text_display":" the following criteria must be met prior to unblinding:","confidence":1,"confidence_rate":1},{"cnt":[[451,1328],[1738,1328],[1738,1373],[451,1373]],"region":{"top_left_x":451,"top_left_y":1327,"width":1288,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11093cfd530c4f83891e963e26cb81d7","type":"text","conversion_output":true,"text":"1. Patient must have an NIHSS score \\(\\geq 6\\) (or new clearly disabling deficit) measured","text_display":"\n1. Patient must have an NIHSS score \\(\\geq 6\\) (or new clearly disabling deficit) measured","confidence":1,"confidence_rate":1},{"cnt":[[516,1371],[975,1371],[975,1416],[516,1416]],"region":{"top_left_x":515,"top_left_y":1370,"width":461,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eec1c7272b7f44a7875581408646716c","type":"text","conversion_output":true,"text":"twice within a 10 -minute span.","text_display":" twice within a 10 -minute span.","confidence":0.867379903793335,"confidence_rate":0.9963584870594434},{"cnt":[[449,1431],[1783,1431],[1783,1474],[449,1474]],"region":{"top_left_x":449,"top_left_y":1430,"width":1335,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3adb3cdb8cb414686a53cb666bc336e","type":"text","conversion_output":true,"text":"2. Patient's NIHSS increase must be \\(\\geq 2\\) points from the pre-treatment NIHSS (e.g., if a","text_display":"\n2. Patient's NIHSS increase must be \\(\\geq 2\\) points from the pre-treatment NIHSS (e.g., if a","confidence":1,"confidence_rate":1},{"cnt":[[516,1474],[1609,1474],[1609,1519],[516,1519]],"region":{"top_left_x":515,"top_left_y":1473,"width":1095,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86ff408f85784499ad8e0880d5637a13","type":"text","conversion_output":true,"text":"patient's pre-treatment NIHSS was 5 , the worsened NIHSS must be \\(\\geq 7\\) ).","text_display":" patient's pre-treatment NIHSS was 5 , the worsened NIHSS must be \\(\\geq 7\\) ).","confidence":0.9951171875,"confidence_rate":0.9999395725372111},{"cnt":[[451,1553],[1755,1553],[1755,1596],[451,1596]],"region":{"top_left_x":451,"top_left_y":1553,"width":1305,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f62917fcb6a646fd82bee7f449d07ed5","type":"text","conversion_output":true,"text":"If the investigator wishes to know the identity of the study drug for any other reason, he","text_display":"\n\nIf the investigator wishes to know the identity of the study drug for any other reason, he","confidence":1,"confidence_rate":1},{"cnt":[[451,1601],[1695,1601],[1695,1644],[451,1644]],"region":{"top_left_x":451,"top_left_y":1600,"width":1245,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"634fca561d0e4c939461545501be2a8c","type":"text","conversion_output":true,"text":"or she should contact the Medical Monitor directly. Treatment codes should not be","text_display":" or she should contact the Medical Monitor directly. Treatment codes should not be","confidence":1,"confidence_rate":1},{"cnt":[[451,1646],[1721,1646],[1721,1689],[451,1689]],"region":{"top_left_x":451,"top_left_y":1645,"width":1270,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbd388afe4274e58982c52c5c757796a","type":"text","conversion_output":true,"text":"broken except under circumstances deemed necessary by the site investigator. The","text_display":" broken except under circumstances deemed necessary by the site investigator. The","confidence":1,"confidence_rate":1},{"cnt":[[451,1693],[1755,1693],[1755,1738],[451,1738]],"region":{"top_left_x":451,"top_left_y":1692,"width":1305,"height":47},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8950af26e544e879d3c772c0881e13f","type":"text","conversion_output":true,"text":"investigator should document and provide an explanation for any premature unblinding","text_display":" investigator should document and provide an explanation for any premature unblinding","confidence":1,"confidence_rate":1},{"cnt":[[451,1738],[1764,1738],[1764,1783],[451,1783]],"region":{"top_left_x":451,"top_left_y":1738,"width":1313,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8e3a37cae37490aa62a3cd963296db1","type":"text","conversion_output":true,"text":"(e.g., unblinding due to sICH, unblinding due to severe systemic bleeding, or unblinding","text_display":" (e.g., unblinding due to sICH, unblinding due to severe systemic bleeding, or unblinding","confidence":1,"confidence_rate":1},{"cnt":[[451,1783],[1749,1783],[1749,1828],[451,1828]],"region":{"top_left_x":451,"top_left_y":1783,"width":1298,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e5be8adf58a45a790c0336c8504edee","type":"text","conversion_output":true,"text":"due to clinical worsening). Following any unblinding event, the site investigator should","text_display":" due to clinical worsening). Following any unblinding event, the site investigator should","confidence":1,"confidence_rate":1},{"cnt":[[451,1830],[1119,1830],[1119,1871],[451,1871]],"region":{"top_left_x":451,"top_left_y":1830,"width":669,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5773368321434d62af8dcd7ba0436be2","type":"text","conversion_output":true,"text":"contact the Medical Monitor within 24 hours.","text_display":" contact the Medical Monitor within 24 hours.","confidence":1,"confidence_rate":1},{"cnt":[[451,1916],[1652,1916],[1652,1957],[451,1957]],"region":{"top_left_x":451,"top_left_y":1916,"width":1202,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2433571253384e2d891d8abe51df1db9","type":"text","conversion_output":true,"text":"For regulatory reporting purposes, and if required by local health authorities, the","text_display":"\n\nFor regulatory reporting purposes, and if required by local health authorities, the","confidence":1,"confidence_rate":1},{"cnt":[[451,1959],[1723,1959],[1723,2004],[451,2004]],"region":{"top_left_x":451,"top_left_y":1959,"width":1273,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7dd3eccb08ce4daaa67f626874ee488b","type":"text","conversion_output":true,"text":"Sponsor will break the treatment code for all serious, unexpected suspected adverse","text_display":" Sponsor will break the treatment code for all serious, unexpected suspected adverse","confidence":1,"confidence_rate":1},{"cnt":[[451,2007],[1704,2007],[1704,2052],[451,2052]],"region":{"top_left_x":451,"top_left_y":2006,"width":1253,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f688dd0ab9ba497cbd2394977da85592","type":"text","conversion_output":true,"text":"reactions (see Section 5.7) that are considered by the investigator or Sponsor to be","text_display":" reactions (see Section 5.7) that are 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Each bottle of aspirin placebo contains 100 tablets labeled for \"clinical trial use","text_display":" blinding. Each bottle of aspirin placebo contains 100 tablets labeled for \"clinical trial use","confidence":1,"confidence_rate":1},{"cnt":[[451,511],[1777,511],[1777,552],[451,552]],"region":{"top_left_x":451,"top_left_y":511,"width":1326,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01013e82a04a4008b3684cd22083daee","type":"text","conversion_output":true,"text":"only.\" Only one tablet will be administered to the patient, and the remainder of the bottle","text_display":" only.\" Only one tablet will be administered to the patient, and the remainder of the bottle","confidence":1,"confidence_rate":1},{"cnt":[[451,559],[1128,559],[1128,599],[451,599]],"region":{"top_left_x":451,"top_left_y":558,"width":677,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bb699eb579a45a893c5550dedb85d79","type":"text","conversion_output":true,"text":"will be kept at the site for drug accountability.","text_display":" will be kept at the site for drug accountability.","confidence":1,"confidence_rate":1},{"cnt":[[451,645],[1691,645],[1691,681],[451,681]],"region":{"top_left_x":451,"top_left_y":644,"width":1240,"height":38},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b382ab5b375341d6ba8f5278c3e3799c","type":"text","conversion_output":true,"text":"Placebo tablets should be stored in the same manner as aspirin tablets: \\(25^{\\circ} C\\) with","text_display":"\n\nPlacebo tablets should be stored in the same manner as aspirin tablets: \\(25^{\\circ} C\\) with","confidence":1,"confidence_rate":1},{"cnt":[[451,690],[1094,690],[1094,728],[451,728]],"region":{"top_left_x":451,"top_left_y":689,"width":643,"height":40},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e61ee1fceb54dd0978cfabc1dc21069","type":"text","conversion_output":true,"text":"excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","text_display":" excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","confidence":1,"confidence_rate":1},{"cnt":[[449,765],[1394,765],[1394,814],[449,814]],"region":{"top_left_x":449,"top_left_y":764,"width":946,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12849080a657426e8eb73284bc4d3926","type":"section_header","conversion_output":false,"children_ids":["9c23fb276c61414788b3d28aea13f38a"],"text":"","text_display":""},{"cnt":[[451,769],[1392,769],[1392,810],[451,810]],"region":{"top_left_x":451,"top_left_y":769,"width":942,"height":41},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c23fb276c61414788b3d28aea13f38a","type":"text","conversion_output":true,"parent_id":"12849080a657426e8eb73284bc4d3926","text":"4.3.2 Dosage, Administration, and Compliance","text_display":"\n\n\\subsection*{4.3.2 Dosage, Administration, and Compliance}","confidence":1,"confidence_rate":1},{"cnt":[[447,816],[840,816],[840,862],[447,862]],"region":{"top_left_x":446,"top_left_y":816,"width":395,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d44e146e998f4728b384035bf54b60d4","type":"section_header","conversion_output":false,"children_ids":["59d793bf4d654a9290e0ac03136b5a54"],"text":"","text_display":""},{"cnt":[[451,819],[836,819],[836,859],[451,859]],"region":{"top_left_x":451,"top_left_y":818,"width":385,"height":42},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59d793bf4d654a9290e0ac03136b5a54","type":"text","conversion_output":true,"parent_id":"d44e146e998f4728b384035bf54b60d4","text":"4.3.2.1 Alteplase","text_display":"\n\n\\subsection*{4.3.2.1 Alteplase}","confidence":1,"confidence_rate":1},{"cnt":[[451,868],[1747,868],[1747,909],[451,909]],"region":{"top_left_x":451,"top_left_y":867,"width":1296,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4efaea4c2b8402c9290757b62588e29","type":"text","conversion_output":true,"text":"For AIS, the recommended dose is \\(0.9 mg / kg\\) infused over 60 minutes with \\(10 \\%\\) of the","text_display":"\n\nFor AIS, the recommended dose is \\(0.9 mg / kg\\) infused over 60 minutes with \\(10 \\%\\) of the","confidence":0.998046875,"confidence_rate":0.9999806434067887},{"cnt":[[451,915],[1742,915],[1742,950],[451,950]],"region":{"top_left_x":451,"top_left_y":915,"width":1292,"height":35},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ca615a7b7fa48879f9f98f93866d984","type":"text","conversion_output":true,"text":"total dose administered as an initial IV bolus over 1 minute. The total dose should not","text_display":" total dose administered as an initial IV bolus over 1 minute. The total dose should not","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[451,962],[677,962],[677,999],[451,999]],"region":{"top_left_x":451,"top_left_y":962,"width":226,"height":38},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b37ba9eede7a495881efbfe90d365e84","type":"text","conversion_output":true,"text":"exceed 90 mg .","text_display":" exceed 90 mg .","confidence":1,"confidence_rate":1},{"cnt":[[451,1046],[1753,1046],[1753,1085],[451,1085]],"region":{"top_left_x":451,"top_left_y":1046,"width":1303,"height":39},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"855baf47c8a148d4a54062c89fd5c8e8","type":"text","conversion_output":true,"text":"Because alteplase and alteplase placebo contain no antibacterial preservatives, \\(50- mg\\)","text_display":"\n\nBecause alteplase and alteplase placebo contain no antibacterial preservatives, \\(50- mg\\)","confidence":0.9834330081939697,"confidence_rate":0.9998184321464346},{"cnt":[[451,1091],[1768,1091],[1768,1130],[451,1130]],"region":{"top_left_x":451,"top_left_y":1091,"width":1318,"height":40},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12785ac28bed464da50fa4c0da765664","type":"text","conversion_output":true,"text":"vials should be reconstituted immediately before use by adding 50 mL of SWFI, USP, to","text_display":" vials should be reconstituted immediately before use by adding 50 mL of SWFI, USP, to","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[451,1139],[1766,1139],[1766,1177],[451,1177]],"region":{"top_left_x":451,"top_left_y":1138,"width":1316,"height":40},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e677eb7d7654adea1d3c9b3a1f75946","type":"text","conversion_output":true,"text":"the vial; this yields a concentration of \\(1 mg / mL\\). Using aseptic technique, direct the flow","text_display":" the vial; this yields a concentration of \\(1 mg / mL\\). Using aseptic technique, direct the flow","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[451,1182],[1687,1182],[1687,1222],[451,1222]],"region":{"top_left_x":451,"top_left_y":1181,"width":1236,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f669da6585414dab8c64045887240e35","type":"text","conversion_output":true,"text":"of SWFI directly into the lyophilized cake of study drug. It is recommended that an","text_display":" of SWFI directly into the lyophilized cake of study drug. It is recommended that an","confidence":1,"confidence_rate":1},{"cnt":[[451,1229],[1734,1229],[1734,1270],[451,1270]],"region":{"top_left_x":451,"top_left_y":1228,"width":1283,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f32e112948d48b3af1e3134be68cc4f","type":"text","conversion_output":true,"text":"\\(18-\\) gauge needle be used for the reconstitution of the \\(50- mg\\) vial. Once reconstituted,","text_display":" \\(18-\\) gauge needle be used for the reconstitution of the \\(50- mg\\) vial. Once reconstituted,","confidence":0.7094185799360275,"confidence_rate":0.9964302456735689},{"cnt":[[451,1276],[1745,1276],[1745,1317],[451,1317]],"region":{"top_left_x":451,"top_left_y":1276,"width":1294,"height":41},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d177a7fd278c4451a8548f0684327dd7","type":"text","conversion_output":true,"text":"gently swirl the vial. Do not shake. Slight foaming upon reconstitution is not unusual;","text_display":" gently swirl the vial. Do not shake. Slight foaming upon reconstitution is not unusual;","confidence":1,"confidence_rate":1},{"cnt":[[451,1321],[1721,1321],[1721,1360],[451,1360]],"region":{"top_left_x":451,"top_left_y":1321,"width":1270,"height":39},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"532f2713f42a48aea394147750883698","type":"text","conversion_output":true,"text":"allowing the vial to stand undisturbed for several minutes is usually sufficient to allow","text_display":" allowing the vial to stand undisturbed for several minutes is usually sufficient to allow","confidence":1,"confidence_rate":1},{"cnt":[[451,1369],[1729,1369],[1729,1407],[451,1407]],"region":{"top_left_x":451,"top_left_y":1368,"width":1279,"height":40},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2793e682f97242fe821489bd2526cb6f","type":"text","conversion_output":true,"text":"dissipation of any large bubbles. Before further dilution or administration, the product","text_display":" dissipation of any large bubbles. Before further dilution or administration, the product","confidence":1,"confidence_rate":1},{"cnt":[[451,1414],[1738,1414],[1738,1454],[451,1454]],"region":{"top_left_x":451,"top_left_y":1413,"width":1288,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7b9f629c9dd467baad90e4a2098258c","type":"text","conversion_output":true,"text":"should be visually inspected for particulate matter and discoloration. If a precipitate is","text_display":" should be visually inspected for particulate matter and discoloration. If a precipitate is","confidence":1,"confidence_rate":1},{"cnt":[[451,1461],[1021,1461],[1021,1500],[451,1500]],"region":{"top_left_x":451,"top_left_y":1460,"width":570,"height":40},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d28b79d5676a4be6a0db16d92dc25eb9","type":"text","conversion_output":true,"text":"seen, the product should not be used.","text_display":" seen, the product should not be used.","confidence":1,"confidence_rate":1},{"cnt":[[451,1545],[1721,1545],[1721,1583],[451,1583]],"region":{"top_left_x":451,"top_left_y":1544,"width":1270,"height":40},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a46516dbe3f4bea99d0575a28a08ac1","type":"text","conversion_output":true,"text":"After reconstitution, alteplase may be administered at \\(1 mg / mL\\). Do not further dilute","text_display":"\n\nAfter reconstitution, alteplase may be administered at \\(1 mg / mL\\). Do not further dilute","confidence":1,"confidence_rate":1},{"cnt":[[451,1590],[1622,1590],[1622,1631],[451,1631]],"region":{"top_left_x":451,"top_left_y":1589,"width":1172,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f06b77f634394934a0044dc2626f791a","type":"text","conversion_output":true,"text":"(e.g., \\(<1 mg / mL\\) ) the solution. The osmolality of this solution is approximately","text_display":" (e.g., \\(<1 mg / mL\\) ) the solution. The osmolality of this solution is approximately","confidence":1,"confidence_rate":1},{"cnt":[[451,1637],[1708,1637],[1708,1678],[451,1678]],"region":{"top_left_x":451,"top_left_y":1637,"width":1258,"height":41},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42ff9e23459541c9b43a7a0ba9fb30bf","type":"text","conversion_output":true,"text":"\\(215 mOsm / kg\\). Polyvinyl chloride bags, glass bottles, or polypropylene syringes are","text_display":" \\(215 mOsm / kg\\). Polyvinyl chloride bags, glass bottles, or polypropylene syringes are","confidence":0.9980475902557373,"confidence_rate":0.9999787576367025},{"cnt":[[451,1684],[1779,1684],[1779,1723],[451,1723]],"region":{"top_left_x":451,"top_left_y":1684,"width":1328,"height":40},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af42341d4345409ea771e6f7c0422ab0","type":"text","conversion_output":true,"text":"acceptable. Do not use filter needles for infusion. Alteplase is stable for up to 8 hours in","text_display":" acceptable. Do not use filter needles for infusion. Alteplase is stable for up to 8 hours in","confidence":1,"confidence_rate":1},{"cnt":[[451,1729],[1747,1729],[1747,1768],[451,1768]],"region":{"top_left_x":451,"top_left_y":1729,"width":1296,"height":40},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b727bb55b424710bf4ddb37c44f325a","type":"text","conversion_output":true,"text":"these solutions at room temperature. Exposure to light has no effect on the stability of","text_display":" these solutions at room temperature. Exposure to light has no effect on the stability of","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[451,1775],[1777,1775],[1777,1815],[451,1815]],"region":{"top_left_x":451,"top_left_y":1774,"width":1326,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d04354ab90b14a6c99e39b42b666b705","type":"text","conversion_output":true,"text":"these solutions. Excessive agitation during dilution should be avoided; mixing should be","text_display":" these solutions. Excessive agitation during dilution should be avoided; mixing should be","confidence":1,"confidence_rate":1},{"cnt":[[451,1822],[1291,1822],[1291,1863],[451,1863]],"region":{"top_left_x":451,"top_left_y":1821,"width":841,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0fa4f883c8548bb8844be3d403375d5","type":"text","conversion_output":true,"text":"accomplished with gentle swirling and/or slow inversion.","text_display":" accomplished with gentle swirling and/or slow inversion.","confidence":1,"confidence_rate":1},{"cnt":[[451,1908],[1721,1908],[1721,1946],[451,1946]],"region":{"top_left_x":451,"top_left_y":1907,"width":1270,"height":40},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca7eb31cd1a14af394cdcf8aadaaad5a","type":"text","conversion_output":true,"text":"No other medication should be added to infusion solutions containing alteplase. Any","text_display":"\n\nNo other medication should be added to infusion solutions containing alteplase. Any","confidence":1,"confidence_rate":1},{"cnt":[[451,1953],[1139,1953],[1139,1987],[451,1987]],"region":{"top_left_x":451,"top_left_y":1952,"width":688,"height":36},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18a2428564dd4bbbba340423ae5b0d52","type":"text","conversion_output":true,"text":"unused infusion solution should be discarded.","text_display":" unused infusion solution should be discarded.","confidence":1,"confidence_rate":1},{"cnt":[[451,2037],[1721,2037],[1721,2078],[451,2078]],"region":{"top_left_x":451,"top_left_y":2036,"width":1270,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2b0c519358d4d078cdbbd6d37bea063","type":"text","conversion_output":true,"text":"Each \\(50- mg\\) vial of Activase contains 50 mg of alteplase, 1.7 g of L-arginine, 5 mg of","text_display":"\n\nEach \\(50- mg\\) vial of Activase contains 50 mg of alteplase, 1.7 g of L-arginine, 5 mg 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The purpose of this is to evaluate for ICH in the patient.","text_display":" initiation of study drug infusion. The purpose of this is to evaluate for ICH in the patient.","confidence":1,"confidence_rate":1},{"cnt":[[451,866],[1781,866],[1781,904],[451,904]],"region":{"top_left_x":451,"top_left_y":865,"width":1331,"height":40},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3498f5196a1e4dfaa098aef76e6788ee","type":"text","conversion_output":true,"text":"An NIHSS should be performed at the time this CT scan or MRI is performed, but prior to","text_display":" An NIHSS should be performed at the time this CT scan or MRI is performed, but prior to","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[451,911],[1734,911],[1734,952],[451,952]],"region":{"top_left_x":451,"top_left_y":910,"width":1283,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3943a66b7a1546d794a8e17b6022d520","type":"text","conversion_output":true,"text":"reviewing imaging results to avoid biasing the assessment. If an MRI is performed, in","text_display":" reviewing imaging results to avoid biasing the assessment. If an MRI is performed, in","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[451,958],[1777,958],[1777,999],[451,999]],"region":{"top_left_x":451,"top_left_y":958,"width":1326,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8111f1c35ee5440ba747463bd7eb9f0e","type":"text","conversion_output":true,"text":"addition to the above requirements for the baseline visit MRI, it must also include T1 and","text_display":" addition to the above requirements for the baseline visit MRI, it must also include T1 and","confidence":1,"confidence_rate":1},{"cnt":[[451,1005],[677,1005],[677,1042],[451,1042]],"region":{"top_left_x":451,"top_left_y":1005,"width":226,"height":37},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83a0e1158e2c45a8b55050c263e51f6f","type":"text","conversion_output":true,"text":"T2 sequences.","text_display":" T2 sequences.","confidence":1,"confidence_rate":1},{"cnt":[[451,1089],[1777,1089],[1777,1128],[451,1128]],"region":{"top_left_x":451,"top_left_y":1089,"width":1326,"height":39},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf7dd72002d54167aabd4d79a4df40b0","type":"text","conversion_output":true,"text":"Additional CT scans or MRIs should be performed based on the investigator's discretion,","text_display":"\n\nAdditional CT scans or MRIs should be performed based on the investigator's discretion,","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[451,1134],[1656,1134],[1656,1175],[451,1175]],"region":{"top_left_x":451,"top_left_y":1134,"width":1206,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3b4c43793ba4781820320576622b2fe","type":"text","conversion_output":true,"text":"or if any clinical findings suggest ICH (such as new headache, nausea, vomiting,","text_display":" or if any clinical findings suggest ICH (such as new headache, nausea, vomiting,","confidence":1,"confidence_rate":1},{"cnt":[[451,1182],[1779,1182],[1779,1222],[451,1222]],"region":{"top_left_x":451,"top_left_y":1181,"width":1328,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5105baea6fa45fab34da6f02ecd3349","type":"text","conversion_output":true,"text":"significant deterioration of neurological status, or rapid increase of blood pressure). If an","text_display":" significant deterioration of neurological status, or rapid increase of blood pressure). If an","confidence":1,"confidence_rate":1},{"cnt":[[451,1225],[1781,1225],[1781,1265],[451,1265]],"region":{"top_left_x":451,"top_left_y":1224,"width":1331,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fedc1b8660ff47929eaa81e6d2524cf2","type":"text","conversion_output":true,"text":"ICH is identified, the NIHSS score should be reassessed at the time and recorded on the","text_display":" ICH is identified, the NIHSS score should be reassessed at the time and recorded on the","confidence":0.98583984375,"confidence_rate":0.9998449971462864},{"cnt":[[451,1272],[782,1272],[782,1308],[451,1308]],"region":{"top_left_x":451,"top_left_y":1271,"width":332,"height":38},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41fdec04f7ab411898f581c525f97e72","type":"text","conversion_output":true,"text":"Adverse Event eCRF.","text_display":" Adverse Event eCRF.","confidence":1,"confidence_rate":1},{"cnt":[[451,1358],[1772,1358],[1772,1399],[451,1399]],"region":{"top_left_x":451,"top_left_y":1357,"width":1322,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e25bc9e73f9048e38c22e81bc8ee7c17","type":"text","conversion_output":true,"text":"CT scans or MRIs performed between 22 to 36 hours, and additional imaging performed","text_display":"\n\nCT scans or MRIs performed between 22 to 36 hours, and additional imaging performed","confidence":1,"confidence_rate":1},{"cnt":[[451,1403],[1777,1403],[1777,1446],[451,1446]],"region":{"top_left_x":451,"top_left_y":1402,"width":1326,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f50d6ce409774b9f9badb4cb1eff8c51","type":"text","conversion_output":true,"text":"due to clinical suspicion of deterioration up until 36 hours after study drug administration,","text_display":" due to clinical suspicion of deterioration up until 36 hours after study drug administration,","confidence":1,"confidence_rate":1},{"cnt":[[451,1448],[1760,1448],[1760,1489],[451,1489]],"region":{"top_left_x":451,"top_left_y":1448,"width":1309,"height":41},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ecda9a421a04095bb644c663d133081","type":"text","conversion_output":true,"text":"will be evaluated by a central team of radiologists blinded to the clinical attributes of the","text_display":" will be evaluated by a central team of radiologists blinded to the clinical attributes of the","confidence":1,"confidence_rate":1},{"cnt":[[451,1500],[537,1500],[537,1534],[451,1534]],"region":{"top_left_x":451,"top_left_y":1499,"width":87,"height":35},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63c54d0818fc4743bf3b86dfd7be5e0f","type":"text","conversion_output":true,"text":"case.","text_display":" case.","confidence":1,"confidence_rate":1},{"cnt":[[447,1571],[1164,1571],[1164,1622],[447,1622]],"region":{"top_left_x":446,"top_left_y":1570,"width":719,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb0ef3b1a20643089ae7ebc2fb3db512","type":"section_header","conversion_output":false,"children_ids":["ad8db1aa0a654f0d9f0dcd0abfb44474"],"text":"","text_display":""},{"cnt":[[451,1573],[1162,1573],[1162,1618],[451,1618]],"region":{"top_left_x":451,"top_left_y":1572,"width":712,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad8db1aa0a654f0d9f0dcd0abfb44474","type":"text","conversion_output":true,"parent_id":"fb0ef3b1a20643089ae7ebc2fb3db512","text":"4.5.2 Patient-Reported Outcomes","text_display":"\n\n\\subsection*{4.5.2 Patient-Reported Outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[451,1633],[1738,1633],[1738,1674],[451,1674]],"region":{"top_left_x":451,"top_left_y":1632,"width":1288,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31075aa662324332b5eb46ff75902f13","type":"text","conversion_output":true,"text":"Patient-reported outcomes (PRO) data will be elicited from the patients in this study to","text_display":"\n\nPatient-reported outcomes (PRO) data will be elicited from the patients in this study to","confidence":1,"confidence_rate":1},{"cnt":[[451,1680],[1708,1680],[1708,1721],[451,1721]],"region":{"top_left_x":451,"top_left_y":1680,"width":1258,"height":41},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bffb6d4764704dc987140a4c7a34680d","type":"text","conversion_output":true,"text":"more fully characterize the clinical profile of alteplase in this patient population. The","text_display":" more fully characterize the clinical profile of alteplase in this patient population. The","confidence":1,"confidence_rate":1},{"cnt":[[451,1725],[1729,1725],[1729,1764],[451,1764]],"region":{"top_left_x":451,"top_left_y":1725,"width":1279,"height":39},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"252977defde84effad007d508049c766","type":"text","conversion_output":true,"text":"PRO questionnaires will be distributed by the investigator staff and completed in their","text_display":" PRO questionnaires will be distributed by the investigator staff and completed in their","confidence":1,"confidence_rate":1},{"cnt":[[451,1770],[1055,1770],[1055,1811],[451,1811]],"region":{"top_left_x":451,"top_left_y":1770,"width":604,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78a03271946b404ba9f6dc29449efa86","type":"text","conversion_output":true,"text":"entirety by the patient or their surrogate.","text_display":" entirety by the patient or their surrogate.","confidence":1,"confidence_rate":1},{"cnt":[[451,1856],[1751,1856],[1751,1897],[451,1897]],"region":{"top_left_x":451,"top_left_y":1856,"width":1300,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef092aeade8349ac9c422f0f6284544c","type":"text","conversion_output":true,"text":"This study will assess the impact of alteplase treatment on health-related quality of life,","text_display":"\n\nThis study will assess the impact of alteplase treatment on health-related quality of life,","confidence":1,"confidence_rate":1},{"cnt":[[451,1904],[1429,1904],[1429,1944],[451,1944]],"region":{"top_left_x":451,"top_left_y":1903,"width":978,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af21495f41e14d8b8f8d79f4000bdba4","type":"text","conversion_output":true,"text":"physical function, daily functioning, and symptoms of depression.","text_display":" physical function, daily functioning, and symptoms of depression.","confidence":1,"confidence_rate":1},{"cnt":[[451,1985],[1781,1985],[1781,2026],[451,2026]],"region":{"top_left_x":451,"top_left_y":1985,"width":1331,"height":41},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b43bbfe2be945c98566b2aa70d0a69d","type":"text","conversion_output":true,"text":"Health-related quality of life will be assessed using the EQ-5D (Appendix 4). The EQ-5D","text_display":"\n\nHealth-related quality of life will be assessed using the EQ-5D (Appendix 4). The EQ-5D","confidence":1,"confidence_rate":1},{"cnt":[[451,2032],[1691,2032],[1691,2073],[451,2073]],"region":{"top_left_x":451,"top_left_y":2032,"width":1240,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6e5ad6ec05d4a48b19094796631a5b0","type":"text","conversion_output":true,"text":"is a generic, preference-based health utility measure with questions about mobility,","text_display":" is a generic, preference-based health utility measure with questions about mobility,","confidence":1,"confidence_rate":1},{"cnt":[[451,2080],[1764,2080],[1764,2121],[451,2121]],"region":{"top_left_x":451,"top_left_y":2079,"width":1313,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e551e10d3e794af5b0d05ce1b8a3f970","type":"text","conversion_output":true,"text":"self-care, usual activities, pain/discomfort, and anxiety/depression that are used to build","text_display":" self-care, usual activities, pain/discomfort, and anxiety/depression that are used to build","confidence":1,"confidence_rate":1},{"cnt":[[451,2125],[1076,2125],[1076,2168],[451,2168]],"region":{"top_left_x":451,"top_left_y":2124,"width":626,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6817250cb0d648aba6bf7a3b3f3f5fca","type":"text","conversion_output":true,"text":"a composite of the patient's health status.","text_display":" a composite of the patient's health status.","confidence":0.99951171875,"confidence_rate":0.999989825041388},{"cnt":[[451,2209],[1644,2209],[1644,2249],[451,2249]],"region":{"top_left_x":451,"top_left_y":2208,"width":1193,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d8f7b70a405464292eb97b6f95816a6","type":"text","conversion_output":true,"text":"Physical functioning will be evaluated using the SIS-16 (Appendix 5), which is a","text_display":"\n\nPhysical functioning will be evaluated using the SIS-16 (Appendix 5), which is a","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[451,2256],[1708,2256],[1708,2297],[451,2297]],"region":{"top_left_x":451,"top_left_y":2255,"width":1258,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87abd73978584e39b2a68b078efc0b75","type":"text","conversion_output":true,"text":"validated, stroke-specific, quality of life measure to assess the impact of stroke on a","text_display":" validated, stroke-specific, quality of life measure to assess the impact of stroke on a","confidence":1,"confidence_rate":1},{"cnt":[[451,2299],[810,2299],[810,2342],[451,2342]],"region":{"top_left_x":451,"top_left_y":2298,"width":359,"height":44},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fed0551c0a91413986607fddf3ac159c","type":"text","conversion_output":true,"text":"patient's health and life.","text_display":" patient's health and 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1","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1745,2428],[1788,2428],[1788,2471],[1745,2471]],"region":{"top_left_x":1744,"top_left_y":2427,"width":44,"height":44},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24958c8128c643eab3f05e5f6ed288f7","type":"page_info","conversion_output":false,"text":"34","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[372,2574],[1416,2574],[1416,2615],[372,2615]],"region":{"top_left_x":371,"top_left_y":2573,"width":1045,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1079711638ce4fdab81194a9b64a3352","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, 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Once consent is obtained, the results of","text_display":" consent will be used in the screening process. Once consent is obtained, the results of","confidence":1,"confidence_rate":1},{"cnt":[[449,881],[1371,881],[1371,926],[449,926]],"region":{"top_left_x":449,"top_left_y":880,"width":922,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca7765da817443ebaee1146b27e84f34","type":"text","conversion_output":true,"text":"the standard of care assessments may be used for the study.","text_display":" the standard of care assessments may be used for the study.","confidence":0.9990234375,"confidence_rate":0.9999847338720312},{"cnt":[[451,941],[750,941],[750,986],[451,986]],"region":{"top_left_x":451,"top_left_y":941,"width":299,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d430286bbc1e45bf93ee8a830d3fcd9b","type":"text","conversion_output":true,"text":"- Medical history","text_display":"\n- Medical 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AESI for this study include the following:","confidence":1,"confidence_rate":1},{"cnt":[[451,1106],[1583,1106],[1583,1147],[451,1147]],"region":{"top_left_x":451,"top_left_y":1106,"width":1133,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad03d6deb69c47da997c38c1fd64fd02","type":"text","conversion_output":true,"text":"- All events of sICH (use a list of preferred terms [PTs] see Appendix 13)","text_display":"\n- All events of sICH (use a list of preferred terms [PTs] see Appendix 13)","confidence":1,"confidence_rate":1},{"cnt":[[451,1164],[1764,1164],[1764,1205],[451,1205]],"region":{"top_left_x":451,"top_left_y":1164,"width":1313,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15b5a46380d64a95b6b3382d8d790469","type":"text","conversion_output":true,"text":"- In addition, Suspected Transmission of an Infectious Agent via a Medicinal Product","text_display":"\n- In addition, Suspected 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All AEs, whether","text_display":"\n\nInvestigators will seek information on AEs at each patient contact. All AEs, whether","confidence":1,"confidence_rate":1},{"cnt":[[451,1878],[1704,1878],[1704,1919],[451,1919]],"region":{"top_left_x":451,"top_left_y":1877,"width":1253,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a06dc742c744814a2850a3bfacb89a7","type":"text","conversion_output":true,"text":"reported by the patient or noted by study personnel, will be recorded in the patient's","text_display":" reported by the patient or noted by study personnel, will be recorded in the patient's","confidence":1,"confidence_rate":1},{"cnt":[[451,1925],[1184,1925],[1184,1962],[451,1962]],"region":{"top_left_x":451,"top_left_y":1925,"width":733,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3f41a33635743a7be398cf247b76b2a","type":"text","conversion_output":true,"text":"medical record and on the Adverse Event eCRF.","text_display":" medical record and on the Adverse Event eCRF.","confidence":1,"confidence_rate":1},{"cnt":[[451,2007],[1777,2007],[1777,2047],[451,2047]],"region":{"top_left_x":451,"top_left_y":2006,"width":1326,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ebbdba8914f4f61b320d7f4ec220433","type":"text","conversion_output":true,"text":"After informed consent has been obtained, but prior to initiation of study drug, only SAEs","text_display":"\n\nAfter informed consent has been obtained, but prior to initiation of study drug, only SAEs","confidence":1,"confidence_rate":1},{"cnt":[[451,2056],[1414,2056],[1414,2099],[451,2099]],"region":{"top_left_x":451,"top_left_y":2056,"width":963,"height":44},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e70160f0f94d4e97bf47c8eb8ab74d32","type":"text","conversion_output":true,"text":"caused by a protocol-mandated intervention should be reported.","text_display":" caused by a protocol-mandated intervention should be reported.","confidence":1,"confidence_rate":1},{"cnt":[[451,2140],[1749,2140],[1749,2181],[451,2181]],"region":{"top_left_x":451,"top_left_y":2139,"width":1298,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f8bfe93705745ada1215f19c4a59b15","type":"text","conversion_output":true,"text":"After initiation of study drug, all AEs, regardless of relationship to study drug, will be","text_display":"\n\nAfter initiation of study drug, all AEs, regardless of relationship to study drug, will be","confidence":0.9985356330871582,"confidence_rate":0.9999845744332286},{"cnt":[[451,2187],[1613,2187],[1613,2228],[451,2228]],"region":{"top_left_x":451,"top_left_y":2187,"width":1163,"height":41},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fe40b9a1bc74b599d5dce36142e09a4","type":"text","conversion_output":true,"text":"reported until 90 days after administration of study drug. 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After this period, the","confidence":1,"confidence_rate":1},{"cnt":[[451,2230],[1764,2230],[1764,2271],[451,2271]],"region":{"top_left_x":451,"top_left_y":2230,"width":1313,"height":41},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a439d74f9964820953308387ee35fb4","type":"text","conversion_output":true,"text":"investigator is not required to actively monitor patients for adverse events; however, the","text_display":" investigator is not required to actively monitor patients for adverse events; however, the","confidence":1,"confidence_rate":1},{"cnt":[[451,2277],[1755,2277],[1755,2318],[451,2318]],"region":{"top_left_x":451,"top_left_y":2277,"width":1305,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c1488392883423482822de24d717940","type":"text","conversion_output":true,"text":"Sponsor should be notified if the investigator becomes aware of any post-study serious","text_display":" Sponsor should be 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Table 4 will be used for assessing severity","text_display":" used for assessing adverse event severity. 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transient or mild discomfort (<48 hours); no medical intervention or therapy required \\\\\n\\hline 2 & Moderate; mild to moderate limitation in activity; some assistance may be needed; no or minimal medical intervention or therapy required \\\\\n\\hline 3 & Severe; marked limitation in activity; some assistance usually required; medical intervention or therapy required; hospitalization possible \\\\\n\\hline 4 & Life-threatening; extreme limitation in activity; significant assistance required; significant medical intervention or therapy required, hospitalization or hospice care probable \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 4 Adverse Event Severity Grading Scale}\n\\begin{tabular}{|l|l|}\n\\hline Grade & Severity \\\\\n\\hline 1 & Mild; transient or mild discomfort (<48 hours); no medical intervention or therapy required \\\\\n\\hline 2 & Moderate; mild to moderate limitation in activity; some assistance may be needed; 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event","confidence":0.99951171875,"confidence_rate":0.9999880878636791},{"cnt":[[451,1955],[1764,1955],[1764,1996],[451,1996]],"region":{"top_left_x":451,"top_left_y":1955,"width":1313,"height":41},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"332479161a254146819aadddd4cf1d69","type":"text","conversion_output":true,"text":"- Presence of non-treatment-related factors that are known to be associated with the","text_display":"\n- Presence of non-treatment-related factors that are known to be associated with the","confidence":1,"confidence_rate":1},{"cnt":[[516,1998],[879,1998],[879,2039],[516,2039]],"region":{"top_left_x":515,"top_left_y":1998,"width":364,"height":41},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca22d89b965f48c283d7cc53925ca50a","type":"text","conversion_output":true,"text":"occurrence of the event","text_display":" occurrence of the 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Inc.","text_display":"","confidence":0.9897787116079724,"confidence_rate":0.9998419527297561},{"cnt":[[372,2608],[694,2608],[694,2645],[372,2645]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":37},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a950cbec6b844da59d75fda35cbeae29","type":"page_info","conversion_output":false,"text":"379/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-044","page":44,"lines":[{"cnt":[[447,367],[1137,367],[1137,410],[447,410]],"region":{"top_left_x":446,"top_left_y":367,"width":691,"height":44},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e396facd1bf4710adfa59a59ef9b09b","type":"figure_label","conversion_output":false,"text":"Table 5 Causal Attribution Guidance","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999886419133848},{"cnt":[[451,432],[1785,432],[1785,1051],[451,1051]],"region":{"top_left_x":451,"top_left_y":431,"width":1335,"height":620},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be4997393b404bba8e48485b8035fff0","type":"table","conversion_output":true,"children_ids":["89212aa63df0403789873069c6a6862d","02172d1c6a96489391aff624c93d270e","ceea4f4ee3f84d74aafaf6310365e1ea","dd0174d3ff954462bbcbcff099a02e27","8b0af4cefeea4fe89a902c36d430e810","5068768ef6fd4fecb82ee394baf5e6ce","dd3782119b5a4ccfb3b415533666068e","2990e624bbab461a8feea0008219ff89","cf114b20e54b43528524015f30677d64","0abb2f15391343c88a190e718cf7c7f1","56982e2cfd414c069ae5e15c46b62b3f","d906aa02da70410d98a7b18545e418fc"],"selected_labels":["2e396facd1bf4710adfa59a59ef9b09b"],"text":"\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|c|}{Is the adverse event suspected to be caused by the study drug on the basis of facts, evidence, science-based rationales, and clinical judgment?} \\\\\n\\hline YES & There is a plausible temporal relationship between the onset of the adverse event and administration of the study drug, and the adverse event cannot be readily explained by the patient's clinical state, intercurrent illness, or concomitant therapies; and/or the adverse event follows a known pattern of response to the study drug; and/or the adverse event abates or resolves upon discontinuation of the study drug or dose reduction and, if applicable, reappears upon re-challenge. \\\\\n\\hline NO & Adverse events will be considered related, unless they fulfill the criteria as specified below. \\\\\n\\hline & Evidence exists that the adverse event has an etiology other than the study drug (e.g., preexisting medical condition, underlying disease, intercurrent illness, or concomitant medication); and/or the adverse event has no plausible temporal relationship to administration of the study drug (e.g., cancer diagnosed 2 days after first dose of study drug). \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 5 Causal Attribution Guidance}\n\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|c|}{Is the adverse event suspected to be caused by the study drug on the basis of facts, evidence, science-based rationales, and clinical judgment?} \\\\\n\\hline YES & There is a plausible temporal relationship between the onset of the adverse event and administration of the study drug, and the adverse event cannot be readily explained by the patient's clinical state, intercurrent illness, or concomitant therapies; and/or the adverse event follows a known pattern of response to the study drug; and/or the adverse event abates or resolves upon discontinuation of the study drug or dose reduction and, if applicable, reappears upon re-challenge. \\\\\n\\hline NO & Adverse events will be considered related, unless they fulfill the criteria as specified below. \\\\\n\\hline & Evidence exists that the adverse event has an etiology other than the study drug (e.g., preexisting medical condition, underlying disease, intercurrent illness, or concomitant medication); and/or the adverse event has no plausible temporal relationship to administration of the study drug (e.g., cancer diagnosed 2 days after first dose of study drug). \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.99609375,"confidence_rate":0.9999985971696861},{"cnt":[[460,431],[544,431],[544,1048],[460,1048]],"region":{"top_left_x":459,"top_left_y":431,"width":86,"height":618},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89212aa63df0403789873069c6a6862d","type":"table_column","conversion_output":false,"parent_id":"be4997393b404bba8e48485b8035fff0","text":"","text_display":""},{"cnt":[[561,434],[1771,431],[1772,1048],[563,1051]],"region":{"top_left_x":561,"top_left_y":430,"width":1211,"height":621},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02172d1c6a96489391aff624c93d270e","type":"table_column","conversion_output":false,"parent_id":"be4997393b404bba8e48485b8035fff0","text":"","text_display":""},{"cnt":[[451,440],[1787,440],[1787,526],[451,526]],"region":{"top_left_x":451,"top_left_y":439,"width":1337,"height":88},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ceea4f4ee3f84d74aafaf6310365e1ea","type":"table_row","conversion_output":false,"parent_id":"be4997393b404bba8e48485b8035fff0","text":"","text_display":""},{"cnt":[[451,531],[1785,531],[1785,762],[451,762]],"region":{"top_left_x":451,"top_left_y":530,"width":1334,"height":233},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd0174d3ff954462bbcbcff099a02e27","type":"table_row","conversion_output":false,"parent_id":"be4997393b404bba8e48485b8035fff0","text":"","text_display":""},{"cnt":[[451,769],[1785,769],[1785,849],[451,849]],"region":{"top_left_x":451,"top_left_y":768,"width":1334,"height":81},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b0af4cefeea4fe89a902c36d430e810","type":"table_row","conversion_output":false,"parent_id":"be4997393b404bba8e48485b8035fff0","text":"","text_display":""},{"cnt":[[451,849],[1785,849],[1785,1046],[451,1046]],"region":{"top_left_x":451,"top_left_y":848,"width":1334,"height":198},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5068768ef6fd4fecb82ee394baf5e6ce","type":"table_row","conversion_output":false,"parent_id":"be4997393b404bba8e48485b8035fff0","text":"","text_display":""},{"cnt":[[462,442],[1774,442],[1774,524],[462,524]],"region":{"top_left_x":461,"top_left_y":441,"width":1314,"height":84},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd3782119b5a4ccfb3b415533666068e","type":"table_spanning_cell","conversion_output":false,"parent_id":"be4997393b404bba8e48485b8035fff0","children_ids":["34eaba25ddef489c9fed63fda61900c9"],"text":"","text_display":"Is 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reduction and, if applicable, reappears upon re-challenge.","confidence":1,"confidence_rate":1},{"cnt":[[468,773],[525,773],[525,808],[468,808]],"region":{"top_left_x":468,"top_left_y":773,"width":57,"height":35},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0abb2f15391343c88a190e718cf7c7f1","type":"simple_cell","conversion_output":false,"parent_id":"be4997393b404bba8e48485b8035fff0","text":"NO","text_display":"NO","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[574,771],[1722,771],[1722,849],[574,849]],"region":{"top_left_x":574,"top_left_y":770,"width":1149,"height":79},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56982e2cfd414c069ae5e15c46b62b3f","type":"complex_cell","conversion_output":false,"parent_id":"be4997393b404bba8e48485b8035fff0","children_ids":["9d6853aa93cf4800ab73f691ec517712","9eb5cc8a24114254926283628b8fe131"],"text":"Adverse events 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that the adverse event has an etiology other than the study drug (e.g., preexisting medical condition, underlying disease, intercurrent illness, or concomitant medication); and/or the adverse event has no plausible temporal relationship to administration of the study drug (e.g., cancer diagnosed 2 days after first dose of study drug).","text_display":"Evidence exists that the adverse event has an etiology other than the study drug (e.g., preexisting medical condition, underlying disease, intercurrent illness, or concomitant medication); and/or the adverse event has no plausible temporal relationship to administration of the study drug (e.g., cancer diagnosed 2 days after first dose of study 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preexisting medical condition, underlying disease, intercurrent illness,","text_display":" (e.g., preexisting medical condition, underlying disease, intercurrent illness,","confidence":1,"confidence_rate":1},{"cnt":[[579,929],[1670,929],[1670,966],[579,966]],"region":{"top_left_x":578,"top_left_y":929,"width":1093,"height":37},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1510f0e003e84b6ebb96041697df27aa","type":"text","conversion_output":false,"parent_id":"d906aa02da70410d98a7b18545e418fc","text":"or concomitant medication); and/or the adverse event has no plausible temporal","text_display":" or concomitant medication); and/or the adverse event has no plausible 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and symptoms (e.g., record only liver failure or hepatitis rather than","confidence":1,"confidence_rate":1},{"cnt":[[449,1229],[1727,1229],[1727,1270],[449,1270]],"region":{"top_left_x":449,"top_left_y":1228,"width":1279,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d4f3bd3a6e04ca0bf08374807905561","type":"text","conversion_output":true,"text":"jaundice, asterixis, and elevated transaminases). However, if a constellation of signs","text_display":" jaundice, asterixis, and elevated transaminases). However, if a constellation of signs","confidence":1,"confidence_rate":1},{"cnt":[[451,1276],[1757,1276],[1757,1315],[451,1315]],"region":{"top_left_x":451,"top_left_y":1276,"width":1307,"height":39},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93e92b68e0a0461cb6181dd62d3c1d53","type":"text","conversion_output":true,"text":"and/or symptoms cannot be medically characterized as a single diagnosis or syndrome","text_display":" and/or symptoms cannot be medically characterized as a single diagnosis or syndrome","confidence":1,"confidence_rate":1},{"cnt":[[451,1319],[1764,1319],[1764,1360],[451,1360]],"region":{"top_left_x":451,"top_left_y":1319,"width":1313,"height":41},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82aa83f0d870487ca65000d44daa06dd","type":"text","conversion_output":true,"text":"at the time of reporting, each individual event should be recorded on the Adverse Event","text_display":" at the time of reporting, each individual event should be recorded on the Adverse Event","confidence":1,"confidence_rate":1},{"cnt":[[451,1366],[1764,1366],[1764,1407],[451,1407]],"region":{"top_left_x":451,"top_left_y":1366,"width":1313,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"200f7fb949da452a9fed96af6be093e4","type":"text","conversion_output":true,"text":"eCRF. 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Such events should only be recorded once on the Adverse Event","text_display":" evaluation timepoints. Such events should only be recorded once on the Adverse Event","confidence":1,"confidence_rate":1},{"cnt":[[451,662],[1742,662],[1742,703],[451,703]],"region":{"top_left_x":451,"top_left_y":661,"width":1292,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30184b339ac44481b1eb963c873653e7","type":"text","conversion_output":true,"text":"eCRF. The initial severity of the event should be recorded, and the severity should be","text_display":" eCRF. 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If the event","confidence":1,"confidence_rate":1},{"cnt":[[451,752],[1601,752],[1601,793],[451,793]],"region":{"top_left_x":451,"top_left_y":751,"width":1150,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07ef7d3605364602b98d21c5fed378e6","type":"text","conversion_output":true,"text":"becomes serious, the Adverse Event eCRF should be updated to reflect this.","text_display":" becomes serious, the Adverse Event eCRF should be updated to reflect this.","confidence":1,"confidence_rate":1},{"cnt":[[451,838],[1618,838],[1618,879],[451,879]],"region":{"top_left_x":451,"top_left_y":837,"width":1167,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67ebcc1b298840b494ad60593906b2cf","type":"text","conversion_output":true,"text":"A recurrent AE is one that resolves between patient evaluation timepoints and","text_display":"\n\nA recurrent AE is one that resolves between patient evaluation timepoints and","confidence":0.5951745298818878,"confidence_rate":0.9941207532099819},{"cnt":[[451,885],[1742,885],[1742,924],[451,924]],"region":{"top_left_x":451,"top_left_y":885,"width":1292,"height":39},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70fd2c2d185a48c69486c0f846a3c94d","type":"text","conversion_output":true,"text":"subsequently recurs. 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A laboratory test result must be","text_display":"\n\nNot every laboratory abnormality qualifies as an AE. A laboratory test result must be","confidence":1,"confidence_rate":1},{"cnt":[[451,1104],[1300,1104],[1300,1145],[451,1145]],"region":{"top_left_x":451,"top_left_y":1104,"width":849,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e050bd8cb6f4e26adfc54985891c97e","type":"text","conversion_output":true,"text":"reported as an \\(A E\\) if it meets any of the following criteria:","text_display":" reported as an \\(A E\\) if it meets any of the following criteria:","confidence":0.6747121810913086,"confidence_rate":0.9942303984870459},{"cnt":[[451,1164],[1046,1164],[1046,1205],[451,1205]],"region":{"top_left_x":451,"top_left_y":1164,"width":596,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4866a73f089748ea93f95bc283c32a09","type":"text","conversion_output":true,"text":"- Accompanied by clinical symptoms","text_display":"\n- Accompanied by clinical symptoms","confidence":1,"confidence_rate":1},{"cnt":[[451,1220],[1656,1220],[1656,1261],[451,1261]],"region":{"top_left_x":451,"top_left_y":1220,"width":1206,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4104cacc19ef47d3a75d8734943b8851","type":"text","conversion_output":true,"text":"- Results in a change in study treatment (e.g., dosage modification, treatment","text_display":"\n- Results in a change in study treatment (e.g., dosage modification, treatment","confidence":1,"confidence_rate":1},{"cnt":[[518,1263],[1139,1263],[1139,1304],[518,1304]],"region":{"top_left_x":517,"top_left_y":1263,"width":622,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa52a02aecba49288a0ef487e99c1ff8","type":"text","conversion_output":true,"text":"interruption, or treatment discontinuation)","text_display":" interruption, or treatment discontinuation)","confidence":1,"confidence_rate":1},{"cnt":[[451,1319],[1777,1319],[1777,1364],[451,1364]],"region":{"top_left_x":451,"top_left_y":1319,"width":1326,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a94cc24dd42409db3776af4b6bb044b","type":"text","conversion_output":true,"text":"- Results in a medical intervention (e.g., potassium supplementation for hypokalemia)","text_display":"\n- Results in a medical intervention (e.g., potassium supplementation for hypokalemia)","confidence":1,"confidence_rate":1},{"cnt":[[516,1366],[1051,1366],[1051,1405],[516,1405]],"region":{"top_left_x":515,"top_left_y":1366,"width":536,"height":40},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f26ec8493e254e739bda53164f5df496","type":"text","conversion_output":true,"text":"or a change in concomitant therapy","text_display":" or a change in concomitant therapy","confidence":1,"confidence_rate":1},{"cnt":[[451,1422],[1265,1422],[1265,1463],[451,1463]],"region":{"top_left_x":451,"top_left_y":1422,"width":815,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9bc30a9891045209a5a19388946ea45","type":"text","conversion_output":true,"text":"- Clinically significant in the investigator's judgment","text_display":"\n- Clinically significant in the investigator's judgment","confidence":0.99951171875,"confidence_rate":0.999991860024828},{"cnt":[[451,1504],[1661,1504],[1661,1545],[451,1545]],"region":{"top_left_x":451,"top_left_y":1503,"width":1210,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7b34dbcb69b4d78b519cb0e21954849","type":"text","conversion_output":true,"text":"It is the investigator's responsibility to review all laboratory findings. 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If the laboratory abnormality can be","text_display":" potassium\" as opposed to \"abnormal potassium\"). If the laboratory abnormality can be","confidence":1,"confidence_rate":1},{"cnt":[[451,2088],[1764,2088],[1764,2127],[451,2127]],"region":{"top_left_x":451,"top_left_y":2088,"width":1313,"height":39},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a1884bf380b4f4881d342ea91e9490d","type":"text","conversion_output":true,"text":"characterized by a precise clinical term per standard definitions, the clinical term should","text_display":" characterized by a precise clinical term per standard definitions, the clinical term should","confidence":1,"confidence_rate":1},{"cnt":[[451,2133],[1721,2133],[1721,2172],[451,2172]],"region":{"top_left_x":451,"top_left_y":2133,"width":1270,"height":40},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83e3c45a66a84fddaa8fec8fd0243965","type":"text","conversion_output":true,"text":"be recorded as the AE. 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A vital sign result must be reported","text_display":"\n\nNot every vital sign abnormality qualifies as an AE. A vital sign result must be reported","confidence":1,"confidence_rate":1},{"cnt":[[451,597],[1167,597],[1167,638],[451,638]],"region":{"top_left_x":451,"top_left_y":597,"width":716,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"016be8c81c7c44328df5f58a99d0ee39","type":"text","conversion_output":true,"text":"as an AE if it meets any of the following criteria:","text_display":" as an AE if it meets any of the following criteria:","confidence":1,"confidence_rate":1},{"cnt":[[451,653],[1051,653],[1051,698],[451,698]],"region":{"top_left_x":451,"top_left_y":653,"width":600,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acd643e331ba4f808d2e2d2880903ecd","type":"text","conversion_output":true,"text":"- Accompanied by clinical symptoms","text_display":"\n- Accompanied by clinical symptoms","confidence":1,"confidence_rate":1},{"cnt":[[451,713],[1661,713],[1661,758],[451,758]],"region":{"top_left_x":451,"top_left_y":713,"width":1210,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfd4a6792b854fc495d5e16106bfd9dc","type":"text","conversion_output":true,"text":"- Results in a change in study treatment (e.g., dosage modification, treatment","text_display":"\n- Results in a change in study treatment (e.g., dosage modification, treatment","confidence":1,"confidence_rate":1},{"cnt":[[516,756],[1141,756],[1141,797],[516,797]],"region":{"top_left_x":515,"top_left_y":756,"width":626,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39be656ff3ab4736b9bd0d70743e5216","type":"text","conversion_output":true,"text":"interruption, or treatment discontinuation)","text_display":" interruption, or treatment discontinuation)","confidence":1,"confidence_rate":1},{"cnt":[[451,812],[1549,812],[1549,857],[451,857]],"region":{"top_left_x":451,"top_left_y":812,"width":1099,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac619acc8cb24ab8978c69d633a04458","type":"text","conversion_output":true,"text":"- Results in a medical intervention or a change in concomitant therapy","text_display":"\n- Results in a medical intervention or a change in concomitant therapy","confidence":1,"confidence_rate":1},{"cnt":[[449,872],[1268,872],[1268,917],[449,917]],"region":{"top_left_x":449,"top_left_y":872,"width":819,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebca078eca5e46a683325d735224901e","type":"text","conversion_output":true,"text":"- Clinically significant in the investigator's judgment","text_display":"\n- Clinically significant in the investigator's judgment","confidence":1,"confidence_rate":1},{"cnt":[[449,952],[1785,952],[1785,995],[449,995]],"region":{"top_left_x":449,"top_left_y":951,"width":1337,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ade5b2d04984795a122cea3e0eea552","type":"text","conversion_output":true,"text":"It is the investigator's responsibility to review all vital sign findings. Medical and scientific","text_display":"\n\nIt is the investigator's responsibility to review all vital sign findings. Medical and scientific","confidence":1,"confidence_rate":1},{"cnt":[[447,997],[1708,997],[1708,1042],[447,1042]],"region":{"top_left_x":446,"top_left_y":996,"width":1263,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4b8ffa479054b4b88372c7d0e7fcc1b","type":"text","conversion_output":true,"text":"judgment should be exercised in deciding whether an isolated vital sign abnormality","text_display":" judgment should be exercised in deciding whether an isolated vital sign abnormality","confidence":1,"confidence_rate":1},{"cnt":[[449,1044],[909,1044],[909,1085],[449,1085]],"region":{"top_left_x":449,"top_left_y":1044,"width":460,"height":41},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84cb4e04f0b841ba895450893e4a5034","type":"text","conversion_output":true,"text":"should be classified as an AE.","text_display":" should be classified as an AE.","confidence":1,"confidence_rate":1},{"cnt":[[451,1128],[1648,1128],[1648,1171],[451,1171]],"region":{"top_left_x":451,"top_left_y":1127,"width":1197,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1601c27d4f5449caa8072b45ce40be9","type":"text","conversion_output":true,"text":"If a clinically significant vital sign abnormality is a sign of a disease or syndrome","text_display":"\n\nIf a clinically significant vital sign abnormality is a sign of a disease or syndrome","confidence":1,"confidence_rate":1},{"cnt":[[451,1173],[1777,1173],[1777,1218],[451,1218]],"region":{"top_left_x":451,"top_left_y":1173,"width":1326,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d150b64b6a1e43cba9417f9b3fefb64f","type":"text","conversion_output":true,"text":"(e.g., high blood pressure), only the diagnosis (i.e., hypertension) should be recorded on","text_display":" (e.g., high blood pressure), only the diagnosis (i.e., hypertension) should be recorded on","confidence":1,"confidence_rate":1},{"cnt":[[451,1220],[840,1220],[840,1259],[451,1259]],"region":{"top_left_x":451,"top_left_y":1220,"width":390,"height":39},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3253422599834875b1c26a1044c4d619","type":"text","conversion_output":true,"text":"the Adverse Event eCRF.","text_display":" the Adverse Event eCRF.","confidence":1,"confidence_rate":1},{"cnt":[[451,1306],[1717,1306],[1717,1347],[451,1347]],"region":{"top_left_x":451,"top_left_y":1306,"width":1266,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c29f26f131f0421389f4a21f6c14a97d","type":"text","conversion_output":true,"text":"Observations of the same clinically significant vital sign abnormality from visit to visit","text_display":"\n\nObservations of the same clinically significant vital sign abnormality from visit to visit","confidence":1,"confidence_rate":1},{"cnt":[[451,1351],[1691,1351],[1691,1394],[451,1394]],"region":{"top_left_x":451,"top_left_y":1351,"width":1240,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40833abac2464920be1fc263191618ee","type":"text","conversion_output":true,"text":"should not be repeatedly recorded on the Adverse Event eCRF unless the etiology","text_display":" should not be repeatedly recorded on the Adverse Event eCRF unless the etiology","confidence":1,"confidence_rate":1},{"cnt":[[451,1396],[1669,1396],[1669,1442],[451,1442]],"region":{"top_left_x":451,"top_left_y":1396,"width":1219,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7ed0860b2fe4ebb8a0d7f8cd9eb19d4","type":"text","conversion_output":true,"text":"changes. 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This includes death","text_display":" and immediately reported to the Sponsor (see Section 5.2.2). This includes death","confidence":1,"confidence_rate":1},{"cnt":[[451,1710],[930,1710],[930,1751],[451,1751]],"region":{"top_left_x":451,"top_left_y":1710,"width":480,"height":41},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38cb47e262994d4aa6d314ec70866193","type":"text","conversion_output":true,"text":"attributed to progression of AIS.","text_display":" attributed to progression of AIS.","confidence":1,"confidence_rate":1},{"cnt":[[451,1796],[1785,1796],[1785,1833],[451,1833]],"region":{"top_left_x":451,"top_left_y":1796,"width":1335,"height":37},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c61b39599c1401d9d5b7273f0b57b1e","type":"text","conversion_output":true,"text":"Death should be considered an outcome and not a distinct event. 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The event or condition","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[451,1841],[1781,1841],[1781,1884],[451,1884]],"region":{"top_left_x":451,"top_left_y":1841,"width":1331,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3726b8cc4d0f4fc6a1178c5ae0646344","type":"text","conversion_output":true,"text":"that caused or contributed to the fatal outcome should be recorded as the single medical","text_display":" that caused or contributed to the fatal outcome should be recorded as the single medical","confidence":1,"confidence_rate":1},{"cnt":[[451,1886],[1656,1886],[1656,1929],[451,1929]],"region":{"top_left_x":451,"top_left_y":1886,"width":1206,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21bec9b5745b4e089e8d8e1555d9c2cc","type":"text","conversion_output":true,"text":"concept on the Adverse Event eCRF. 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The term \"sudden death\" should only be used for the occurrence of an abrupt","confidence":1,"confidence_rate":1},{"cnt":[[451,1979],[1693,1979],[1693,2022],[451,2022]],"region":{"top_left_x":451,"top_left_y":1978,"width":1242,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78da2cfdcde942409f64202a52b63d89","type":"text","conversion_output":true,"text":"and unexpected death due to presumed cardiac causes in a patient with or without","text_display":" and unexpected death due to presumed cardiac causes in a patient with or without","confidence":1,"confidence_rate":1},{"cnt":[[451,2024],[1785,2024],[1785,2069],[451,2069]],"region":{"top_left_x":451,"top_left_y":2023,"width":1335,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c46b772e80b045c285174939445d005a","type":"text","conversion_output":true,"text":"preexisting heart disease, within 1 hour of the onset of acute symptoms or, in the case of","text_display":" preexisting heart disease, within 1 hour of the onset of acute symptoms or, in the case of","confidence":1,"confidence_rate":1},{"cnt":[[451,2071],[1742,2071],[1742,2116],[451,2116]],"region":{"top_left_x":451,"top_left_y":2071,"width":1292,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10c3f31ff6ad41f18272d756b7e9064e","type":"text","conversion_output":true,"text":"an unwitnessed death, within 24 hours after the patient was last seen alive and stable.","text_display":" an unwitnessed death, within 24 hours after the patient was last seen alive and stable.","confidence":1,"confidence_rate":1},{"cnt":[[451,2118],[1708,2118],[1708,2159],[451,2159]],"region":{"top_left_x":451,"top_left_y":2118,"width":1258,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12b0f936121441029df279f6b0deaf50","type":"text","conversion_output":true,"text":"If the cause of death is unknown and cannot be ascertained at the time of reporting,","text_display":" If the cause of death is unknown and cannot be ascertained at the time of reporting,","confidence":0.994140625,"confidence_rate":0.9999339728710218},{"cnt":[[451,2161],[1732,2161],[1732,2206],[451,2206]],"region":{"top_left_x":451,"top_left_y":2161,"width":1281,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b42902e4eb62475aa0565d754b2c2b53","type":"text","conversion_output":true,"text":"\"unexplained death\" should be recorded on the Adverse Event eCRF. 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death is attributed to progression of AIS, \"acute ischemic stroke progression\"","confidence":1,"confidence_rate":1},{"cnt":[[451,421],[1184,421],[1184,458],[451,458]],"region":{"top_left_x":451,"top_left_y":421,"width":733,"height":37},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3102774aa6dc46439280c5a5878b468b","type":"text","conversion_output":true,"text":"should be recorded on the Adverse Event eCRF.","text_display":" should be recorded on the Adverse Event 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The primary","text_display":" therapy over standard medical care in AIS patients with mild symptoms. The primary","confidence":1,"confidence_rate":1},{"cnt":[[451,2307],[1691,2307],[1691,2348],[451,2348]],"region":{"top_left_x":451,"top_left_y":2307,"width":1240,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e8eeedc35e5464696b994f58ace2a24","type":"text","conversion_output":true,"text":"efficacy outcome is the proportion of patients with a favorable outcome, defined by","text_display":" efficacy outcome is the proportion of patients with a favorable outcome, defined by","confidence":1,"confidence_rate":1},{"cnt":[[451,2391],[853,2391],[853,2430],[451,2430]],"region":{"top_left_x":451,"top_left_y":2391,"width":402,"height":39},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a773857e958f4b8fa8a0cdb1784b8b0b","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936616389313713,"confidence_rate":0.9997880713345346},{"cnt":[[451,2428],[851,2428],[851,2464],[451,2464]],"region":{"top_left_x":451,"top_left_y":2427,"width":400,"height":38},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8b42f85515e4728b8cb23b03427a487","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 1","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1745,2428],[1788,2428],[1788,2471],[1745,2471]],"region":{"top_left_x":1744,"top_left_y":2427,"width":44,"height":44},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a3c09f81005492fb9f920a4d2a4b517","type":"page_info","conversion_output":false,"text":"50","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bef926fdfb2747b98f6cd17c02b7b065","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9931802598336503,"confidence_rate":0.999894727066751},{"cnt":[[374,2608],[692,2608],[692,2645],[374,2645]],"region":{"top_left_x":373,"top_left_y":2608,"width":319,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"facb15d8e0644f35a4bdc7f7fe0919d1","type":"page_info","conversion_output":false,"text":"387/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-052","page":52,"lines":[{"cnt":[[449,374],[1760,374],[1760,419],[449,419]],"region":{"top_left_x":449,"top_left_y":373,"width":1311,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"883b0e5a441543839fe3201488356f20","type":"text","conversion_output":true,"text":"mRS score of 0 or 1 at 90 days post-randomization. The difference in the proportion of","text_display":"\nmRS score of 0 or 1 at 90 days post-randomization. The difference in the proportion of","confidence":0.9936609268188477,"confidence_rate":0.9999376563510858},{"cnt":[[449,421],[1742,421],[1742,466],[449,466]],"region":{"top_left_x":449,"top_left_y":421,"width":1294,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"337e632c293046a68765e70eaafccc28","type":"text","conversion_output":true,"text":"\\(mRS 0-1\\) responders (favorable outcome) at 90 days post-randomization between the","text_display":" \\(mRS 0-1\\) responders (favorable outcome) at 90 days post-randomization between the","confidence":0.9202851913869381,"confidence_rate":0.9990670459630706},{"cnt":[[451,466],[1577,466],[1577,509],[451,509]],"region":{"top_left_x":451,"top_left_y":466,"width":1126,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f86ccbd7b8ee4e4ebb04809601d9cc16","type":"text","conversion_output":true,"text":"IV alteplase arm and the standard medical care arm will be compared via a","text_display":" IV alteplase arm and the standard medical care arm will be compared via a","confidence":1,"confidence_rate":1},{"cnt":[[451,511],[1755,511],[1755,556],[451,556]],"region":{"top_left_x":451,"top_left_y":511,"width":1305,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"651b4162e72e4822abb1671fe451b3a7","type":"text","conversion_output":true,"text":"Cochran-Mantel-Haenszel test, stratified by pre-treatment NIHSS score ( \\(0-2\\) vs. 3-5),","text_display":" Cochran-Mantel-Haenszel test, stratified by pre-treatment NIHSS score ( \\(0-2\\) vs. 3-5),","confidence":0.8430577693507075,"confidence_rate":0.9981659871399026},{"cnt":[[451,559],[1729,559],[1729,604],[451,604]],"region":{"top_left_x":451,"top_left_y":558,"width":1279,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5594aa5bdf754d9c87876ffa19d35241","type":"text","conversion_output":true,"text":"age (<65 vs. \\(\\geq 65\\) ), and last known well time to treatment ( \\(0-2\\) hours vs. \\(2-3\\) hours).","text_display":" age (<65 vs. \\(\\geq 65\\) ), and last known well time to treatment ( \\(0-2\\) hours vs. \\(2-3\\) hours).","confidence":0.7052466782545838,"confidence_rate":0.9964788639001382},{"cnt":[[449,606],[1764,606],[1764,649],[449,649]],"region":{"top_left_x":449,"top_left_y":605,"width":1315,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc9c064d457e4e8abc4cdd5a94cc23bc","type":"text","conversion_output":true,"text":"The primary efficacy analysis will include all randomized patients, with patients grouped","text_display":" The primary efficacy analysis will include all randomized patients, with patients grouped","confidence":1,"confidence_rate":1},{"cnt":[[451,653],[1695,653],[1695,694],[451,694]],"region":{"top_left_x":451,"top_left_y":653,"width":1245,"height":41},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d4d4bd539254cd89035815eca3b8e7b","type":"text","conversion_output":true,"text":"according to the treatment assigned at randomization adhering to the ITT principle.","text_display":" according to the treatment assigned at randomization adhering to the ITT principle.","confidence":1,"confidence_rate":1},{"cnt":[[449,696],[1704,696],[1704,741],[449,741]],"region":{"top_left_x":449,"top_left_y":696,"width":1255,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a4eec12c7b5469f892a76aac463e750","type":"text","conversion_output":true,"text":"A patient is considered enrolled and randomized in the trial, and included in the ITT","text_display":" A patient is considered enrolled and randomized in the trial, and included in the ITT","confidence":1,"confidence_rate":1},{"cnt":[[451,743],[1708,743],[1708,788],[451,788]],"region":{"top_left_x":451,"top_left_y":743,"width":1258,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"698d1c4c264f4b949924f1b9fffa610c","type":"text","conversion_output":true,"text":"population, as soon as study drug begins. As a sensitivity analysis, results from the","text_display":" population, as soon as study drug begins. As a sensitivity analysis, results from the","confidence":1,"confidence_rate":1},{"cnt":[[451,791],[1338,791],[1338,831],[451,831]],"region":{"top_left_x":451,"top_left_y":790,"width":888,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb3d5b8cfad34f2f930dc0ac891dfb81","type":"text","conversion_output":true,"text":"univariate Pearson's chi-square test will also be presented.","text_display":" univariate Pearson's chi-square test will also be presented.","confidence":1,"confidence_rate":1},{"cnt":[[449,872],[1811,872],[1811,917],[449,917]],"region":{"top_left_x":449,"top_left_y":872,"width":1363,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09b4b7124bba490392c1c9c226f756ce","type":"text","conversion_output":true,"text":"As a supportive, secondary analysis, an ordinal (or \"shift\") analysis of the distribution of the","text_display":"\n\nAs a supportive, secondary analysis, an ordinal (or \"shift\") analysis of the distribution of the","confidence":1,"confidence_rate":1},{"cnt":[[451,920],[1790,920],[1790,965],[451,965]],"region":{"top_left_x":451,"top_left_y":919,"width":1339,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c16d2842ca794994b4df0e900e3c5cf6","type":"text","conversion_output":true,"text":"mRS will be analyzed via proportional odds model if the proportionality assumption holds,","text_display":" mRS will be analyzed via proportional odds model if the proportionality assumption holds,","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[451,967],[1777,967],[1777,1012],[451,1012]],"region":{"top_left_x":451,"top_left_y":966,"width":1326,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bc7931319f44d66a46c889df387c12b","type":"text","conversion_output":true,"text":"and by the Mann-Whitney superiority measure if the proportionality assumption does not","text_display":" and by the Mann-Whitney superiority measure if the proportionality assumption does not","confidence":1,"confidence_rate":1},{"cnt":[[451,1010],[1729,1010],[1729,1055],[451,1055]],"region":{"top_left_x":451,"top_left_y":1009,"width":1279,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ceed742febb42b3b8f1dcc68d321d97","type":"text","conversion_output":true,"text":"hold. The proportionality assumption will be assessed using the score test as well as","text_display":" hold. The proportionality assumption will be assessed using the score test as well as","confidence":1,"confidence_rate":1},{"cnt":[[451,1057],[1781,1057],[1781,1102],[451,1102]],"region":{"top_left_x":451,"top_left_y":1057,"width":1331,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d18a17491cba4dacacb0a09933c9d49a","type":"text","conversion_output":true,"text":"clinical judgment on the similarities of the different odds ratios. Other secondary efficacy","text_display":" clinical judgment on the similarities of the different odds ratios. Other secondary efficacy","confidence":1,"confidence_rate":1},{"cnt":[[451,1104],[1807,1104],[1807,1149],[451,1149]],"region":{"top_left_x":451,"top_left_y":1104,"width":1356,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac186ef65064480aa0a5364c5788bc9c","type":"text","conversion_output":true,"text":"outcomes of interest include NIHSS score, BI, GOS, and global outcome scale at 90 days.","text_display":" outcomes of interest include NIHSS score, BI, GOS, and global outcome scale at 90 days.","confidence":1,"confidence_rate":1},{"cnt":[[449,1152],[1729,1152],[1729,1195],[449,1195]],"region":{"top_left_x":449,"top_left_y":1151,"width":1281,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e88ff7c83d241f49d697b549ccee193","type":"text","conversion_output":true,"text":"These results will be treated as supportive evidence (or lack thereof) of the treatment","text_display":" These results will be treated as supportive evidence (or lack thereof) of the treatment","confidence":1,"confidence_rate":1},{"cnt":[[451,1195],[1768,1195],[1768,1240],[451,1240]],"region":{"top_left_x":451,"top_left_y":1194,"width":1318,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04f033e35284416b993c8d34f9927d3e","type":"text","conversion_output":true,"text":"effect rather than conclusive evidence, the significance of each test is determined at the","text_display":" effect rather than conclusive evidence, the significance of each test is determined at the","confidence":0.99560546875,"confidence_rate":0.9999536409105637},{"cnt":[[449,1242],[1760,1242],[1760,1287],[449,1287]],"region":{"top_left_x":449,"top_left_y":1241,"width":1311,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ff322985cc64a599543ee4e2a89856d","type":"text","conversion_output":true,"text":"two-sided alpha level of 0.05 . The specific statistical model for analyzing each of these","text_display":" two-sided alpha level of 0.05 . The specific statistical model for analyzing each of these","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[449,1289],[1543,1289],[1543,1334],[449,1334]],"region":{"top_left_x":449,"top_left_y":1289,"width":1094,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d680f14ff3e648e9b8dbcf78f5a1d160","type":"text","conversion_output":true,"text":"outcome measures will be detailed in the Statistical Analysis Plan (SAP).","text_display":" outcome measures will be detailed in the Statistical Analysis Plan (SAP).","confidence":0.9990234375,"confidence_rate":0.9999874739291208},{"cnt":[[443,1358],[1023,1358],[1023,1412],[443,1412]],"region":{"top_left_x":442,"top_left_y":1357,"width":581,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77d894d626f640a49ade58eb2cf30660","type":"section_header","conversion_output":false,"children_ids":["db1afb7ee7cf49d994011e7032b95a43"],"text":"","text_display":""},{"cnt":[[451,1362],[1016,1362],[1016,1407],[451,1407]],"region":{"top_left_x":451,"top_left_y":1362,"width":566,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db1afb7ee7cf49d994011e7032b95a43","type":"text","conversion_output":true,"parent_id":"77d894d626f640a49ade58eb2cf30660","text":"6.3 SAFETY ANALYSIS","text_display":"\n\n\\subsection*{6.3 SAFETY ANALYSIS}","confidence":0.9951210021972656,"confidence_rate":0.9997962316398862},{"cnt":[[451,1431],[1697,1431],[1697,1474],[451,1474]],"region":{"top_left_x":451,"top_left_y":1430,"width":1247,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dbacdd8775945d8bc9601708e164476","type":"text","conversion_output":true,"text":"Incidence and severity of AEs will be described for all treated patients by treatment","text_display":"\n\nIncidence and severity of AEs will be described for all treated patients by treatment","confidence":1,"confidence_rate":1},{"cnt":[[449,1474],[1712,1474],[1712,1519],[449,1519]],"region":{"top_left_x":449,"top_left_y":1473,"width":1264,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"677845ac4db24ac9b7759c6d1ef0c68c","type":"text","conversion_output":true,"text":"group as received and by the Medical Dictionary for Regulatory Activities (MedDRA)","text_display":" group as received and by the Medical Dictionary for Regulatory Activities (MedDRA)","confidence":1,"confidence_rate":1},{"cnt":[[451,1521],[657,1521],[657,1562],[451,1562]],"region":{"top_left_x":451,"top_left_y":1521,"width":207,"height":41},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3ba1961455b4fd98a9fb64e75f1f6f8","type":"text","conversion_output":true,"text":"classification.","text_display":" classification.","confidence":1,"confidence_rate":1},{"cnt":[[451,1605],[1695,1605],[1695,1652],[451,1652]],"region":{"top_left_x":451,"top_left_y":1604,"width":1245,"height":49},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbca7cfd04aa438c987b14f288a3229e","type":"text","conversion_output":true,"text":"Primary safety outcomes include incidence of sICH within 36 hours, any ICH within","text_display":"\n\nPrimary safety outcomes include incidence of sICH within 36 hours, any ICH within","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[451,1652],[1772,1652],[1772,1695],[451,1695]],"region":{"top_left_x":451,"top_left_y":1652,"width":1322,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"570ee1417a4d47979cf2a2603292b35c","type":"text","conversion_output":true,"text":"36 hours, overall mortality, and stroke-related and neurological deaths within 90 days of","text_display":" 36 hours, overall mortality, and stroke-related and neurological deaths within 90 days of","confidence":1,"confidence_rate":1},{"cnt":[[451,1697],[1755,1697],[1755,1742],[451,1742]],"region":{"top_left_x":451,"top_left_y":1697,"width":1305,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f926c46609d4cffaeaaeffbfce4d5a8","type":"text","conversion_output":true,"text":"study drug initiation. The cumulative incidences of each outcome will be compared via","text_display":" study drug initiation. The cumulative incidences of each outcome will be compared via","confidence":1,"confidence_rate":1},{"cnt":[[451,1745],[1734,1745],[1734,1790],[451,1790]],"region":{"top_left_x":451,"top_left_y":1744,"width":1283,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a81fe6d237a142269fe1f286dc5cec55","type":"text","conversion_output":true,"text":"Fisher's exact test. Mortality will be analyzed by Log-Rank test and the Kaplan-Meier","text_display":" Fisher's exact test. Mortality will be analyzed by Log-Rank test and the Kaplan-Meier","confidence":1,"confidence_rate":1},{"cnt":[[451,1792],[1742,1792],[1742,1835],[451,1835]],"region":{"top_left_x":451,"top_left_y":1791,"width":1292,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac8cfbf61ead461dab3af3e12704a9e0","type":"text","conversion_output":true,"text":"estimates will be plotted over the observation period of 90 days. No alpha adjustment","text_display":" estimates will be plotted over the observation period of 90 days. 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The primary pre-specified variables and","text_display":" by various pre-specified baseline covariates. 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Reconstitute","text_display":"\n\nA single \\(50- mg\\) vial of Activase may be used to treat patients weighing up to 122 lbs or 55.5 kilograms. Reconstitute","confidence":0.9946353406417074,"confidence_rate":0.9999601556025834},{"cnt":[[451,516],[1762,516],[1762,552],[451,552]],"region":{"top_left_x":451,"top_left_y":515,"width":1311,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ef75807449214e29a8fbca3c4fabb479","type":"text","conversion_output":true,"text":"Activase immediately before administration, using aseptic technique at all times-including thorough hand washing","text_display":" Activase immediately before administration, using aseptic technique at all times-including thorough hand washing","confidence":0.9824302196502686,"confidence_rate":0.99984850753582},{"cnt":[[451,546],[709,546],[709,580],[451,580]],"region":{"top_left_x":451,"top_left_y":545,"width":258,"height":36},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"92c7c46d4cf54c07a4609770377bf35b","type":"text","conversion_output":true,"text":"and the use of gloves.","text_display":" and the use of gloves.","confidence":1,"confidence_rate":1},{"cnt":[[451,578],[690,578],[690,1089],[451,1089]],"region":{"top_left_x":451,"top_left_y":577,"width":239,"height":513},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9a5c09920a0d439dbe171e7929a63d9b","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-067.jpg?height=513&width=239&top_left_y=577&top_left_x=451)"},{"cnt":[[554,1091],[647,1091],[647,1130],[554,1130]],"region":{"top_left_x":554,"top_left_y":1091,"width":93,"height":40},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8f82b6ddf8f443cda5372f18a634f292","type":"section_header","conversion_output":false,"children_ids":["c4418b3070bd4c528985652937be67c1"],"text":"","text_display":""},{"cnt":[[554,1096],[647,1096],[647,1128],[554,1128]],"region":{"top_left_x":554,"top_left_y":1095,"width":93,"height":33},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c4418b3070bd4c528985652937be67c1","type":"text","conversion_output":true,"parent_id":"8f82b6ddf8f443cda5372f18a634f292","text":"Step 1:","text_display":"\n\n\\section*{Step 1:}","confidence":1,"confidence_rate":1},{"cnt":[[593,1139],[1751,1139],[1751,1171],[593,1171]],"region":{"top_left_x":592,"top_left_y":1138,"width":1159,"height":33},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fb00182b4ed84077a639815872068b3c","type":"text","conversion_output":true,"text":"Assemble the \\(50- mg\\) vial of Activase, the vial of Sterile Water for Injection (SWFI), USP (included with","text_display":"\n\nAssemble the \\(50- mg\\) vial of Activase, the vial of Sterile Water for Injection (SWFI), USP (included with","confidence":0.8924976043635979,"confidence_rate":0.9990028531875974},{"cnt":[[593,1169],[1751,1169],[1751,1201],[593,1201]],"region":{"top_left_x":592,"top_left_y":1168,"width":1159,"height":33},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c423ba411ec54eec93c1079a910fd5be","type":"text","conversion_output":true,"text":"the Actixase package), a \\(50- mL\\) syringe, a large-bore needle (eg, 18-gauge), and alcohol wipes. Also,","text_display":" the Actixase package), a \\(50- mL\\) syringe, a large-bore needle (eg, 18-gauge), and alcohol wipes. 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Swab the top of each","text_display":"\n\nRemove the protective cap from the top of the Activase vial and the vial of SWFI. Swab the top of each","confidence":0.996584415435791,"confidence_rate":0.9999680245206695},{"cnt":[[593,1332],[1280,1332],[1280,1364],[593,1364]],"region":{"top_left_x":592,"top_left_y":1332,"width":689,"height":33},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"333122f5032040d8a200763437fd5657","type":"text","conversion_output":true,"text":"vial with an alcohol wipe to reduce the risk of contamination","text_display":" vial with an alcohol wipe to reduce the risk of contamination","confidence":1,"confidence_rate":1},{"cnt":[[554,1388],[647,1388],[647,1429],[554,1429]],"region":{"top_left_x":554,"top_left_y":1387,"width":93,"height":42},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a86e3b05009243ed9367ff86f54157a2","type":"section_header","conversion_output":false,"children_ids":["44e0a22f57b14d9e90de7676d5950083"],"text":"","text_display":""},{"cnt":[[556,1392],[647,1392],[647,1424],[556,1424]],"region":{"top_left_x":556,"top_left_y":1392,"width":91,"height":33},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"44e0a22f57b14d9e90de7676d5950083","type":"text","conversion_output":true,"parent_id":"a86e3b05009243ed9367ff86f54157a2","text":"Step 3:","text_display":"\n\n\\section*{Step 3:}","confidence":1,"confidence_rate":1},{"cnt":[[593,1431],[1772,1431],[1772,1465],[593,1465]],"region":{"top_left_x":592,"top_left_y":1430,"width":1181,"height":36},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"13d6e80580ae4347b3bff5944e617d5e","type":"text","conversion_output":true,"text":"Withdraw \\(50- mL\\) of SWFI, without preservatives. Diluent is included. DO NOT USE Bacteriostatic Water","text_display":"\n\nWithdraw \\(50- mL\\) of SWFI, without preservatives. Diluent is included. DO NOT USE Bacteriostatic Water","confidence":0.9970729344058782,"confidence_rate":0.9999733516475424},{"cnt":[[593,1461],[801,1461],[801,1497],[593,1497]],"region":{"top_left_x":592,"top_left_y":1460,"width":210,"height":38},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6006c35463964c6994dfef7c867b87ab","type":"text","conversion_output":true,"text":"for Injection, USP","text_display":" for Injection, USP","confidence":1,"confidence_rate":1},{"cnt":[[554,1521],[647,1521],[647,1560],[554,1560]],"region":{"top_left_x":554,"top_left_y":1521,"width":93,"height":39},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0174393a8e6f468287699b48e63f29af","type":"section_header","conversion_output":false,"children_ids":["ab2aaf91e8a3488393d86f9320c53b77"],"text":"","text_display":""},{"cnt":[[556,1525],[647,1525],[647,1558],[556,1558]],"region":{"top_left_x":556,"top_left_y":1525,"width":91,"height":33},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ab2aaf91e8a3488393d86f9320c53b77","type":"text","conversion_output":true,"parent_id":"0174393a8e6f468287699b48e63f29af","text":"Step 4:","text_display":"\n\n\\section*{Step 4:}","confidence":1,"confidence_rate":1},{"cnt":[[593,1568],[1781,1568],[1781,1601],[593,1601]],"region":{"top_left_x":592,"top_left_y":1568,"width":1190,"height":33},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c1485db9e2d343a39078a72f8f20acbb","type":"text","conversion_output":true,"text":"Inject the \\(50- mL\\) into the \\(50- mg\\) Activase vial using a large-bore needle and syringe, directing the stream","text_display":"\n\nInject the \\(50- mL\\) into the \\(50- mg\\) Activase vial using a large-bore needle and syringe, directing the stream","confidence":0.9975600242614746,"confidence_rate":0.9999799759600713},{"cnt":[[593,1594],[1721,1594],[1721,1626],[593,1626]],"region":{"top_left_x":592,"top_left_y":1594,"width":1129,"height":33},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"00bd386f700a45c7997462974096a7d8","type":"text","conversion_output":true,"text":"into the lyophilized cake. DONOT USE IF VACUUM IS NOT PRESENT. The syringe should not be","text_display":" into the lyophilized cake. DONOT USE IF VACUUM IS NOT PRESENT. The syringe should not be","confidence":0.7850074768066406,"confidence_rate":0.9974005667943755},{"cnt":[[593,1624],[1764,1624],[1764,1656],[593,1656]],"region":{"top_left_x":592,"top_left_y":1624,"width":1172,"height":33},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"98aa25dd5a984d499d3cb8bc7192dcdb","type":"text","conversion_output":true,"text":"primed with air during preparation and should be inserted into the Activase vial stopper. Slight foaming","text_display":" primed with air during preparation and should be inserted into the Activase vial stopper. Slight foaming","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[593,1654],[1760,1654],[1760,1687],[593,1687]],"region":{"top_left_x":592,"top_left_y":1654,"width":1168,"height":33},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1294631448244e2db1e0eff807ee3a1c","type":"text","conversion_output":true,"text":"upon reconstitution is normal. Let the solution stand undisturbed for several minutes to allow any large","text_display":" upon reconstitution is normal. Let the solution stand undisturbed for several minutes to allow any large","confidence":1,"confidence_rate":1},{"cnt":[[593,1684],[831,1684],[831,1717],[593,1717]],"region":{"top_left_x":592,"top_left_y":1684,"width":240,"height":33},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4638eeb7125c417186247da8b9490a73","type":"text","conversion_output":true,"text":"bubbles to dissipate","text_display":" bubbles to dissipate","confidence":1,"confidence_rate":1},{"cnt":[[554,1740],[647,1740],[647,1781],[554,1781]],"region":{"top_left_x":554,"top_left_y":1740,"width":93,"height":42},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"00587995214d4280aae93c7ad02ae009","type":"section_header","conversion_output":false,"children_ids":["8a7ceb5982884e32a504d9cc547b3b72"],"text":"","text_display":""},{"cnt":[[559,1745],[647,1745],[647,1777],[559,1777]],"region":{"top_left_x":558,"top_left_y":1744,"width":89,"height":33},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8a7ceb5982884e32a504d9cc547b3b72","type":"text","conversion_output":true,"parent_id":"00587995214d4280aae93c7ad02ae009","text":"Step 5:","text_display":"\n\n\\section*{Step 5:}","confidence":1,"confidence_rate":1},{"cnt":[[593,1783],[1725,1783],[1725,1820],[593,1820]],"region":{"top_left_x":592,"top_left_y":1783,"width":1134,"height":37},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2c86623313804d7b820fa02174a98d16","type":"text","conversion_output":true,"text":"Mix with a gentle swirl or slow inversion. DO NOT SHAKE. Visually inspect the Activase solution for","text_display":"\n\nMix with a gentle swirl or slow inversion. DO NOT SHAKE. Visually inspect the Activase solution for","confidence":0.7599994565825909,"confidence_rate":0.9973646559328372},{"cnt":[[593,1815],[1253,1815],[1253,1850],[593,1850]],"region":{"top_left_x":592,"top_left_y":1815,"width":661,"height":35},"line":31,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"28dc4a7cacdb4e8289466171b09d6df8","type":"text","conversion_output":true,"text":"particulate matter and discoloration before administration","text_display":" particulate matter and discoloration before administration","confidence":1,"confidence_rate":1},{"cnt":[[451,1876],[1695,1876],[1695,1910],[451,1910]],"region":{"top_left_x":451,"top_left_y":1875,"width":1245,"height":35},"line":32,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8b96a13723624398ac597ea4a5f73ac5","type":"text","conversion_output":true,"text":"Activase is stable for up to 8 hours in these solutions at room temperature. 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\\multirow{3}{*}{} & \\multicolumn{4}{|c|}{During the Past} \\\\\n\\hline & \\multicolumn{4}{|l|}{Week} \\\\\n\\hline & Rarely or none of the time (less than 1 day) & Some or a little of the time (1-2 days) & Occasionally or a moderate amount of time (3-4 days) & Most or all of the time (5-7 days) \\\\\n\\hline 1. I was bothered by things that usually don't bother me. & □ & □ & □ & □ \\\\\n\\hline 2. I did not feel like eating; my appetite was poor. & □ & □ & □ & □ \\\\\n\\hline 3. I felt that I could not shake off the blues even with help from my family or friends. & □ & □ & □ & □ \\\\\n\\hline 4. I felt I was just as good as other people. & □ & □ & □ & □ \\\\\n\\hline 5. I had trouble keeping my mind on what I was doing. & □ & □ & □ & □ \\\\\n\\hline 6. I felt depressed. & □ & □ & □ & □ \\\\\n\\hline 7. I feit that everything I did was an effort. & □ & □ & □ & □ \\\\\n\\hline 8. I felt hopeful about the future. & □ & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-071.jpg?height=43\\&width=42\\&top_left_y=1293\\&top_left_x=1450) & □ \\\\\n\\hline 9. I thought my life had been a failure. & □ & □ & □ & □ \\\\\n\\hline 10. I felt fearful. & □ & □ & □ & □ \\\\\n\\hline 11. My sleep was restless. & □ & □ & □ & □ \\\\\n\\hline 12. I was happy. & □ & □ & □ & □ \\\\\n\\hline 13. I talked less than usual. & □ & □ & □ & □ \\\\\n\\hline 14. I felt lonely. & □ & □ & □ & □ \\\\\n\\hline 15. People were unfriendly. & □ & □ & □ & □ \\\\\n\\hline 16. I enjoyed life. & □ & □ & □ & □ \\\\\n\\hline 17. I had crying spells. & □ & □ & □ & □ \\\\\n\\hline 18. I felt sad. & □ & □ & □ & □ \\\\\n\\hline 19. I felt that people dislike me. & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-071.jpg?height=39\\&width=46\\&top_left_y=1730\\&top_left_x=1013) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-071.jpg?height=39\\&width=46\\&top_left_y=1732\\&top_left_x=1209) & □ & □ \\\\\n\\hline 20. I could not get \"going.\" & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-071.jpg?height=42\\&width=44\\&top_left_y=1768\\&top_left_x=1209) & □ & □ \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multirow{3}{*}{} & \\multicolumn{4}{|c|}{During the Past} \\\\\n\\hline & \\multicolumn{4}{|l|}{Week} \\\\\n\\hline & Rarely or none of the time (less than 1 day) & Some or a little of the time (1-2 days) & Occasionally or a moderate amount of time (3-4 days) & Most or all of the time (5-7 days) \\\\\n\\hline 1. I was bothered by things that usually don't bother me. & □ & □ & □ & □ \\\\\n\\hline 2. I did not feel like eating; my appetite was poor. & □ & □ & □ & □ \\\\\n\\hline 3. I felt that I could not shake off the blues even with help from my family or friends. & □ & □ & □ & □ \\\\\n\\hline 4. I felt I was just as good as other people. & □ & □ & □ & □ \\\\\n\\hline 5. I had trouble keeping my mind on what I was doing. & □ & □ & □ & □ \\\\\n\\hline 6. I felt depressed. & □ & □ & □ & □ \\\\\n\\hline 7. I feit that everything I did was an effort. & □ & □ & □ & □ \\\\\n\\hline 8. I felt hopeful about the future. & □ & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-071.jpg?height=43\\&width=42\\&top_left_y=1293\\&top_left_x=1450) & □ \\\\\n\\hline 9. I thought my life had been a failure. & □ & □ & □ & □ \\\\\n\\hline 10. I felt fearful. & □ & □ & □ & □ \\\\\n\\hline 11. My sleep was restless. & □ & □ & □ & □ \\\\\n\\hline 12. I was happy. & □ & □ & □ & □ \\\\\n\\hline 13. I talked less than usual. & □ & □ & □ & □ \\\\\n\\hline 14. I felt lonely. & □ & □ & □ & □ \\\\\n\\hline 15. People were unfriendly. & □ & □ & □ & □ \\\\\n\\hline 16. I enjoyed life. & □ & □ & □ & □ \\\\\n\\hline 17. I had crying spells. & □ & □ & □ & □ \\\\\n\\hline 18. I felt sad. & □ & □ & □ & □ \\\\\n\\hline 19. I felt that people dislike me. & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-071.jpg?height=39\\&width=46\\&top_left_y=1730\\&top_left_x=1013) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-071.jpg?height=39\\&width=46\\&top_left_y=1732\\&top_left_x=1209) & □ & □ \\\\\n\\hline 20. 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1","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1745,2428],[1788,2428],[1788,2471],[1745,2471]],"region":{"top_left_x":1744,"top_left_y":2427,"width":44,"height":44},"line":254,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17f18acdf7bb47f6a7f2ae9fde5efd8b","type":"page_info","conversion_output":false,"text":"70","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":255,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce6962a986954c3195399cfcc3d193c0","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9941527741057143,"confidence_rate":0.9999097827182513},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":256,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"031ffa5510c74462a5bc189be24b85b7","type":"page_info","conversion_output":false,"text":"407/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-072","page":72,"lines":[{"cnt":[[980,363],[1222,363],[1222,419],[980,419]],"region":{"top_left_x":979,"top_left_y":363,"width":244,"height":56},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba90e8e4d24d483ba15109e62e996adf","type":"section_header","conversion_output":false,"children_ids":["9bf3619e9d254ac0ab58209b04014218"],"text":"","text_display":""},{"cnt":[[984,367],[1218,367],[1218,415],[984,415]],"region":{"top_left_x":983,"top_left_y":367,"width":236,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bf3619e9d254ac0ab58209b04014218","type":"text","conversion_output":true,"parent_id":"ba90e8e4d24d483ba15109e62e996adf","text":"Appendix 7","text_display":"\n\n\\section*{Appendix 7}","confidence":1,"confidence_rate":1},{"cnt":[[608,408],[1626,408],[1626,462],[608,462]],"region":{"top_left_x":608,"top_left_y":408,"width":1019,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ff85faf76a14a8a826defe61a680c92","type":"section_header","conversion_output":false,"children_ids":["a011b64727c841fb9b6f8e66f46ad53e"],"text":"","text_display":""},{"cnt":[[610,408],[1624,408],[1624,458],[610,458]],"region":{"top_left_x":610,"top_left_y":408,"width":1015,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a011b64727c841fb9b6f8e66f46ad53e","type":"text","conversion_output":true,"parent_id":"6ff85faf76a14a8a826defe61a680c92","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":"\n\n\\section*{National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.980478048324585,"confidence_rate":0.999641609294705},{"cnt":[[460,486],[1803,486],[1803,1979],[460,1979]],"region":{"top_left_x":459,"top_left_y":485,"width":1344,"height":1494},"line":5,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"669f286c09b5464ab9aab8d865e8bf06","type":"table","conversion_output":true,"children_ids":["1e85265251fd4839a7b772e19df8252d","354c4d16f9534e76881f6101e21f9611","fedeea848a5c4cb68f54c23d848ee4f6","f580666210444dc68d1a9cac951276ee","c96925f8c04944da8b3938ecd73fdf00","f3413e0756494f91a3dd0e7850e2aea6","4adeda9f00d14ff2816f7980191ff6c5","a0b45d29e12249b684b16d78e6f44349","840b11c3a3f742a2906f048b4c6faf6a","9757f8fea32244989c476e84d90d6bfc","669e81f33d254eb98c951f2aa8acfdca","e27c1bb3ee2c4e0da53a510c670f27b9","cb0f1d9d7fd04c8bb9bce4b08bc20c26","7b2bfd7b706140fd851f2b06d12541f9","79db6ba1786a43ec950df652e07ccace","7248165006e54ce7820f008d17e12d0f","8becc9ecbc184bc6a2bfa6fed8621b86","dc96b052311046f992761b7759f20e68","c8f5d3136c814b8a942aab653ca1a98d","8dc3635fce494d80b68e9493f0ecb491","f0a0d3aa45614bcb8b304eb2a8a8862a","4406933678b24c079efc4f475bb56cb3","ab6e8b0d8a884f8bb5b33be6bb753343","7fc529dc3a7244a1bc5e1b3462e2ddb8","1cc2c04f53d344cabf0cb4c6b420839f"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|l|}{Administer stroke scale items in the order listed. Record performance in each category after each subscale exam. Do not go back and change scores. Follow directions provided for each exam technique. Scores should reflect what the patent does, not what the clinician thinks the patient can do. The clinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be coached (i.e., repeated requests to patient to make a special effort).} \\\\\n\\hline 1 & Has the subject had a stroke (either as the index event at randomization or as an outcome event)? If no, form is complete. & ◯ No\n◯ Yes \\\\\n\\hline 2 & \\begin{tabular}{l}\n(1a) Level of Consciousness \\\\\nThe investigator must choose a response, even ra ruil evaluation is prevented by such coutales as an endotracheal tube, language bamer, onotracheal traumabandages. A 3 is soored only if the patient makes no movement (other than refexve posturing) in response to noxous stimuation, Coma score \\({ }^{+} 3^{+}\\)\n\\end{tabular} & ◯ 0=Alert; keenly responsive\n◯ \\(1=\\) Not alert, but arousable by minor stimulation to obey, answer or respond\n◯ \\(2=\\) Not alert, requires repeated stimulation to attend, or is obtunded and requires strong or paintul stimulation to make movements (not stereotyped)\n◯ 3=Responds only with reflex motor or autonomic effects or totally unresponsive, flaccid, areflexic (Complete form using coma sconing) \\\\\n\\hline 3 & \\begin{tabular}{l}\n(1b) LOC Questions \\\\\nThe pattent is asked the month and his/her age. The answer must be correct - There is no partial credit for being dose. Aphasic and stuporous patients who do not comprenend the questons will score 2. Paterits unable to speas. because of endotracheal intudation, orotrachea trauma, severe dysarthra from any cause, language barmer or any omer problem not secondary to aphasia are glven a i. Ris important that only the ntal answer be graded and frut the examiner not 'bep' the patent with vertal of non-vertal cues. Coma score \\({ }^{-1} 2^{-}\\).\n\\end{tabular} & ◯ 0=Answers both questions correctly\n◯ 1=Answers one question correctly\n◯ 2-Answers nether question correctly \\\\\n\\hline 4 & \\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and close the eyes and then to gro and release the non-paretic hand Substhile another one step command if the hands cannot be used. Credt is given if an unequlvocal attempt is made but not completed due to weakness. If the patent does not respond to commund, the task should be demonstrated to them (pantomime) and score the result (le. follows none, one of two commands). Patients with trauma, amputation, or other physical impedinents should be given sultable one-step commands. Ony the frat attempt is scored. Coma score \"2\".\n\\end{tabular} & ◯ \\(0=\\) Performs both tasks correctly\n◯ \\(1=\\) Performs one task correctly\n◯ 2=Performs neither task correctly \\\\\n\\hline 5 & \\begin{tabular}{l}\n(2) Best Gaze \\\\\nOnly hortzontax eye movements will be tested. Voluntary or reflexve (coulocephails) eye movements will pe scored but caloric testing is not othe If the patient has 3 confugate olviaton of the byes that can be covercome by voluntary or refextve actively, the score will be i, ir a pasent has an isolated peripheral nerve paresis (CN III, IV or VI) score a 1, Guxe is testable in all aphasic patents, Patents attry ocular trauma, bandages, pro-existing bindiness or other discrider of visual aculty or belds should be tested with reflexter movements and a choice made by the investigator. Estabolishing eye contact and then moving about the patert: from side to side willi occasionaly clarity the presence of a partial gaze palsy. Coma score as examined.\n\\end{tabular} & ◯ \\(0 \\pi\\) Nomal\n◯ \\(1=\\) Partial gaze palsy. This score is given when gaze is abnomal in one or both eyes, but where forced deviation or total gaze paresis are not present\n◯ 2=Forced deviation, or total gaze paresis not overcome by the oculocephalic maneuver \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|l|}{Administer stroke scale items in the order listed. Record performance in each category after each subscale exam. Do not go back and change scores. Follow directions provided for each exam technique. Scores should reflect what the patent does, not what the clinician thinks the patient can do. The clinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be coached (i.e., repeated requests to patient to make a special effort).} \\\\\n\\hline 1 & Has the subject had a stroke (either as the index event at randomization or as an outcome event)? If no, form is complete. & ◯ No\n◯ Yes \\\\\n\\hline 2 & \\begin{tabular}{l}\n(1a) Level of Consciousness \\\\\nThe investigator must choose a response, even ra ruil evaluation is prevented by such coutales as an endotracheal tube, language bamer, onotracheal traumabandages. A 3 is soored only if the patient makes no movement (other than refexve posturing) in response to noxous stimuation, Coma score \\({ }^{+} 3^{+}\\)\n\\end{tabular} & ◯ 0=Alert; keenly responsive\n◯ \\(1=\\) Not alert, but arousable by minor stimulation to obey, answer or respond\n◯ \\(2=\\) Not alert, requires repeated stimulation to attend, or is obtunded and requires strong or paintul stimulation to make movements (not stereotyped)\n◯ 3=Responds only with reflex motor or autonomic effects or totally unresponsive, flaccid, areflexic (Complete form using coma sconing) \\\\\n\\hline 3 & \\begin{tabular}{l}\n(1b) LOC Questions \\\\\nThe pattent is asked the month and his/her age. The answer must be correct - There is no partial credit for being dose. Aphasic and stuporous patients who do not comprenend the questons will score 2. Paterits unable to speas. because of endotracheal intudation, orotrachea trauma, severe dysarthra from any cause, language barmer or any omer problem not secondary to aphasia are glven a i. Ris important that only the ntal answer be graded and frut the examiner not 'bep' the patent with vertal of non-vertal cues. Coma score \\({ }^{-1} 2^{-}\\).\n\\end{tabular} & ◯ 0=Answers both questions correctly\n◯ 1=Answers one question correctly\n◯ 2-Answers nether question correctly \\\\\n\\hline 4 & \\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and close the eyes and then to gro and release the non-paretic hand Substhile another one step command if the hands cannot be used. Credt is given if an unequlvocal attempt is made but not completed due to weakness. If the patent does not respond to commund, the task should be demonstrated to them (pantomime) and score the result (le. follows none, one of two commands). Patients with trauma, amputation, or other physical impedinents should be given sultable one-step commands. Ony the frat attempt is scored. Coma score \"2\".\n\\end{tabular} & ◯ \\(0=\\) Performs both tasks correctly\n◯ \\(1=\\) Performs one task correctly\n◯ 2=Performs neither task correctly \\\\\n\\hline 5 & \\begin{tabular}{l}\n(2) Best Gaze \\\\\nOnly hortzontax eye movements will be tested. Voluntary or reflexve (coulocephails) eye movements will pe scored but caloric testing is not othe If the patient has 3 confugate olviaton of the byes that can be covercome by voluntary or refextve actively, the score will be i, ir a pasent has an isolated peripheral nerve paresis (CN III, IV or VI) score a 1, Guxe is testable in all aphasic patents, Patents attry ocular trauma, bandages, pro-existing bindiness or other discrider of visual aculty or belds should be tested with reflexter movements and a choice made by the investigator. Estabolishing eye contact and then moving about the patert: from side to side willi occasionaly clarity the presence of a partial gaze palsy. Coma score as examined.\n\\end{tabular} & ◯ \\(0 \\pi\\) Nomal\n◯ \\(1=\\) Partial gaze palsy. This score is given when gaze is abnomal in one or both eyes, but where forced deviation or total gaze paresis are not present\n◯ 2=Forced deviation, or total gaze paresis not overcome by the oculocephalic maneuver \\\\\n\\hline\n\\end{tabular}","confidence":0.0020835262219374012,"confidence_rate":0.9914494812030317},{"cnt":[[464,485],[520,485],[520,1979],[464,1979]],"region":{"top_left_x":464,"top_left_y":485,"width":57,"height":1494},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1e85265251fd4839a7b772e19df8252d","type":"table_column","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","text":"","text_display":""},{"cnt":[[530,485],[1153,485],[1153,1977],[530,1977]],"region":{"top_left_x":529,"top_left_y":485,"width":625,"height":1493},"line":7,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"354c4d16f9534e76881f6101e21f9611","type":"table_column","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","text":"","text_display":""},{"cnt":[[1151,485],[1797,485],[1797,1977],[1151,1977]],"region":{"top_left_x":1150,"top_left_y":485,"width":648,"height":1493},"line":8,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fedeea848a5c4cb68f54c23d848ee4f6","type":"table_column","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","text":"","text_display":""},{"cnt":[[459,489],[1803,489],[1803,606],[459,606]],"region":{"top_left_x":459,"top_left_y":489,"width":1344,"height":118},"line":9,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f580666210444dc68d1a9cac951276ee","type":"table_row","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","text":"","text_display":""},{"cnt":[[459,639],[1803,639],[1803,732],[459,732]],"region":{"top_left_x":459,"top_left_y":639,"width":1344,"height":93},"line":10,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c96925f8c04944da8b3938ecd73fdf00","type":"table_row","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","text":"","text_display":""},{"cnt":[[459,792],[1803,792],[1803,1099],[459,1099]],"region":{"top_left_x":459,"top_left_y":791,"width":1344,"height":308},"line":11,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f3413e0756494f91a3dd0e7850e2aea6","type":"table_row","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","text":"","text_display":""},{"cnt":[[459,1138],[1803,1138],[1803,1373],[459,1373]],"region":{"top_left_x":459,"top_left_y":1138,"width":1344,"height":236},"line":12,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4adeda9f00d14ff2816f7980191ff6c5","type":"table_row","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","text":"","text_display":""},{"cnt":[[459,1396],[1803,1396],[1803,1646],[459,1646]],"region":{"top_left_x":459,"top_left_y":1396,"width":1344,"height":250},"line":13,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a0b45d29e12249b684b16d78e6f44349","type":"table_row","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","text":"","text_display":""},{"cnt":[[459,1668],[1803,1668],[1803,1954],[459,1954]],"region":{"top_left_x":459,"top_left_y":1667,"width":1344,"height":288},"line":14,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"840b11c3a3f742a2906f048b4c6faf6a","type":"table_row","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","text":"","text_display":""},{"cnt":[[462,490],[1799,490],[1799,606],[462,606]],"region":{"top_left_x":461,"top_left_y":490,"width":1338,"height":117},"line":15,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9757f8fea32244989c476e84d90d6bfc","type":"table_spanning_cell","conversion_output":false,"parent_id":"669f286c09b5464ab9aab8d865e8bf06","children_ids":["6112d9c6ae924a1684ea47f504022b70"],"text":"","text_display":"Administer stroke scale items in the order listed. Record performance in each category after each subscale exam. Do not go back and change scores. Follow directions provided for each exam technique. Scores should reflect what the patent does, not what the clinician thinks the patient can do. The clinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be coached (i.e., repeated requests to patient to make a special effort).","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":3},{"cnt":[[467,499],[1763,499],[1763,604],[467,604]],"region":{"top_left_x":467,"top_left_y":498,"width":1297,"height":106},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6112d9c6ae924a1684ea47f504022b70","type":"complex_cell","conversion_output":false,"parent_id":"9757f8fea32244989c476e84d90d6bfc","children_ids":["9091eefc507e44fb9f88ca0b2299ef49","b08e6c9aca0646bc8988d6e5192ade4a","fa86d3d3658b4b4a8de0a49c4ea05a90","c9b3bc4906e040a5b38e459ed0f3c91f"],"text":"Administer stroke scale items in the order listed. Record performance in each category after each subscale exam. Do not go back and change scores. Follow directions provided for each exam technique. Scores should reflect what the patent does, not what the clinician thinks the patient can do. The clinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be coached (i.e., repeated requests to patient to make a special effort).","text_display":"Administer stroke scale items in the order listed. Record performance in each category after each subscale exam. Do not go back and change scores. Follow directions provided for each exam technique. Scores should reflect what the patent does, not what the clinician thinks the patient can do. The clinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be coached (i.e., repeated requests to patient to make a special effort).","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":3,"confidence":0.926902443188169,"confidence_rate":0.9998389204278573},{"cnt":[[471,503],[1737,503],[1737,531],[471,531]],"region":{"top_left_x":471,"top_left_y":502,"width":1267,"height":30},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9091eefc507e44fb9f88ca0b2299ef49","type":"text","conversion_output":false,"parent_id":"6112d9c6ae924a1684ea47f504022b70","text":"Administer stroke scale items in the order listed. Record performance in each category after each subscale exam. Do not go back and change","text_display":"Administer stroke scale items in the order listed. Record performance in each category after each subscale exam. 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Scores should reflect what the patent does, not what the clinician thinks the patient","confidence":0.926902443188169,"confidence_rate":0.9994940816316543},{"cnt":[[473,550],[1739,550],[1739,579],[473,579]],"region":{"top_left_x":472,"top_left_y":550,"width":1267,"height":30},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fa86d3d3658b4b4a8de0a49c4ea05a90","type":"text","conversion_output":false,"parent_id":"6112d9c6ae924a1684ea47f504022b70","text":"can do. The clinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be","text_display":" can do. The clinician should record answers while administering the exam and work quickly. 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If no, form is complete.","text_display":"Has the subject had a stroke (either as the index event at randomization or as an outcome event)? 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A 3 is soored only if the patient makes no movement (other than refexve posturing) in response to noxous stimuation, Coma score \\({ }^{+} 3^{+}\\)\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(1a) Level of Consciousness \\\\\nThe investigator must choose a response, even ra ruil evaluation is prevented by such coutales as an endotracheal tube, language bamer, onotracheal traumabandages. 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A 3 is soored only if the patient makes no","text_display":" onotracheal traumabandages. 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or respond\n◯ \\(2=\\) Not alert, requires repeated stimulation to attend, or is obtunded and requires strong or paintul stimulation to make movements (not stereotyped)\n◯ 3=Responds only with reflex motor or autonomic effects or totally unresponsive, flaccid, areflexic (Complete form using coma sconing)","text_display":"◯ 0=Alert; keenly responsive\n◯ \\(1=\\) Not alert, but arousable by minor stimulation to obey, answer or respond\n◯ \\(2=\\) Not alert, requires repeated stimulation to attend, or is obtunded and requires strong or paintul stimulation to make movements (not stereotyped)\n◯ 3=Responds only with reflex motor or autonomic effects or totally unresponsive, flaccid, areflexic (Complete form using coma 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Credt is given if an unequlvocal attempt is made but not completed due to weakness. If the patent does not respond to commund, the task should be demonstrated to them (pantomime) and score the result (le. follows none, one of two commands). Patients with trauma, amputation, or other physical impedinents should be given sultable one-step commands. Ony the frat attempt is scored. Coma score \"2\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and close the eyes and then to gro and release the non-paretic hand Substhile another one step command if the hands cannot be used. Credt is given if an unequlvocal attempt is made but not completed due to weakness. If the patent does not respond to commund, the task should be demonstrated to them (pantomime) and score the result (le. follows none, one of two commands). Patients with trauma, amputation, or other physical impedinents should be given sultable one-step commands. 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This score is given when gaze is abnomal in one or both eyes, but where forced deviation or total gaze paresis are not present\n◯ 2=Forced deviation, or total gaze paresis not overcome by the oculocephalic maneuver","text_display":"◯ \\(0 \\pi\\) Nomal\n◯ \\(1=\\) Partial gaze palsy. 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This score is given when gaze is abnomal","text_display":" \\(1=\\) Partial gaze palsy. 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(cont.)","confidence":1,"confidence_rate":1},{"cnt":[[610,412],[1624,412],[1624,458],[610,458]],"region":{"top_left_x":610,"top_left_y":412,"width":1015,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd2f4fee0cb248bf891f55efc79737ae","type":"text","conversion_output":true,"parent_id":"d8c3eceeafc94f3e912156834fdc4cd5","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":" National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.9775390625,"confidence_rate":0.999587048446442},{"cnt":[[453,509],[1811,509],[1811,2017],[453,2017]],"region":{"top_left_x":453,"top_left_y":509,"width":1359,"height":1509},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b95237158c814207a9024bccc6986028","type":"table","conversion_output":true,"children_ids":["37e8f2ac5919431ca8e4f048ce84583d","e7ea0b0ae6be434fb6c29d8041a66fa3","73da515dffbd42d0aff848be7854e8e3","b350fb6983054b5e93243c0d2766cb84","780aeffdc61e4c85851c9ca937ac1c1b","a2036b05cb694162b7beaa97e1ae82ca","cb8e71c4ea4a47df9d273bc494784884","72ed95109d8245fc973913ea5896a3a7","f649e84e974941cca96cfefc60e0c369","3474624551f248f09e36c722befaf708","e638ed25423145bfbfa3935d224daba4","c0491e09534d42b8ab6060474057cfd2","1473554c598642cebcc31da39c99a116","eeccca4a84d64021b3de4bda8a58a578","e2f1627b0fde4fc9b6425938b4e42b81","f40e8755283448b0a67cbaad7e60a8ca","31a9effe918a46dab99d753aedefdf04","0ca21065e49642fd9683ed876550f607","37d1f9b8f57b49338c6547206203e4ba","e363ec3f122c41b6beda127412408446","55f4e409ed064a7487e6d4af0a38de4e","6cef5d91458d4bf39c40df92125e68c7","733a6a4aa5a9435699c76a2df82605c9","901ac15ff34648f38b8f2f2d450496b4","cf6e5011f89e41c2b3a9a2011ac486d5"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline 8 & \\begin{tabular}{l}\n(3) Visual \\\\\nVIsual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, out if they look at the side of the moving fingers appropitately, this can be scored as normal. If there Is unliateral bilndness or enucleaton, visual flelds in the remaining eye are scored. Score 1 only if a clear-cut asymmetry, Including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous stimulation is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22 . Score as examined, using bilateral threat.\n\\end{tabular} & ◯ 0=No visual loss\n◯ 1 =Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral hemianopia (blind including cortical blindness) \\\\\n\\hline 7 & Ask, or use pantomime to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responslve or non-comprehending patent. If facial traumalbandages, orotracheal tude, tape or other physical barrier obscures the face, these should be removed to the extent possible. Coma Score \" 3 \". & ◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face) \\\\\n\\hline 8 & \\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (ir sitting) or 45 degrees (ir supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shouder or hip can the examiner indicate no score and an explanation must be provided. Coma Score \" 4 \".\n\\end{tabular} & ◯ 0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 9 & Explain if amputation or joint fusion (Motor Arm Left): & \\\\\n\\hline 10 & \\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm tals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0 =No drift, limb holds 90 (or 45 ) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 11 & Explain if amputation or joint fusion (Motor Arm Right): & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 8 & \\begin{tabular}{l}\n(3) Visual \\\\\nVIsual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, out if they look at the side of the moving fingers appropitately, this can be scored as normal. If there Is unliateral bilndness or enucleaton, visual flelds in the remaining eye are scored. Score 1 only if a clear-cut asymmetry, Including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous stimulation is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22 . Score as examined, using bilateral threat.\n\\end{tabular} & ◯ 0=No visual loss\n◯ 1 =Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral hemianopia (blind including cortical blindness) \\\\\n\\hline 7 & Ask, or use pantomime to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responslve or non-comprehending patent. If facial traumalbandages, orotracheal tude, tape or other physical barrier obscures the face, these should be removed to the extent possible. Coma Score \" 3 \". & ◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face) \\\\\n\\hline 8 & \\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (ir sitting) or 45 degrees (ir supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shouder or hip can the examiner indicate no score and an explanation must be provided. Coma Score \" 4 \".\n\\end{tabular} & ◯ 0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 9 & Explain if amputation or joint fusion (Motor Arm Left): & \\\\\n\\hline 10 & \\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm tals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0 =No drift, limb holds 90 (or 45 ) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 11 & Explain if amputation or joint fusion (Motor Arm Right): & \\\\\n\\hline\n\\end{tabular}","confidence":0.03578945687643408,"confidence_rate":0.9964270442124888},{"cnt":[[476,509],[512,509],[512,2018],[476,2018]],"region":{"top_left_x":476,"top_left_y":509,"width":36,"height":1509},"line":5,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"37e8f2ac5919431ca8e4f048ce84583d","type":"table_column","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"","text_display":""},{"cnt":[[525,509],[1198,508],[1199,2016],[526,2017]],"region":{"top_left_x":524,"top_left_y":508,"width":676,"height":1510},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e7ea0b0ae6be434fb6c29d8041a66fa3","type":"table_column","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"","text_display":""},{"cnt":[[1199,509],[1799,509],[1799,2018],[1199,2018]],"region":{"top_left_x":1199,"top_left_y":509,"width":601,"height":1509},"line":7,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"73da515dffbd42d0aff848be7854e8e3","type":"table_column","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"","text_display":""},{"cnt":[[453,523],[1812,523],[1812,753],[453,753]],"region":{"top_left_x":453,"top_left_y":522,"width":1359,"height":232},"line":8,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b350fb6983054b5e93243c0d2766cb84","type":"table_row","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"","text_display":""},{"cnt":[[453,817],[1812,817],[1812,1048],[453,1048]],"region":{"top_left_x":453,"top_left_y":817,"width":1359,"height":231},"line":9,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"780aeffdc61e4c85851c9ca937ac1c1b","type":"table_row","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"","text_display":""},{"cnt":[[453,1113],[1812,1113],[1812,1435],[453,1435]],"region":{"top_left_x":453,"top_left_y":1113,"width":1359,"height":323},"line":10,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a2036b05cb694162b7beaa97e1ae82ca","type":"table_row","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"","text_display":""},{"cnt":[[453,1482],[1812,1480],[1812,1518],[453,1520]],"region":{"top_left_x":452,"top_left_y":1479,"width":1360,"height":41},"line":11,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cb8e71c4ea4a47df9d273bc494784884","type":"table_row","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"","text_display":""},{"cnt":[[453,1584],[1812,1584],[1812,1902],[453,1902]],"region":{"top_left_x":453,"top_left_y":1583,"width":1359,"height":319},"line":12,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"72ed95109d8245fc973913ea5896a3a7","type":"table_row","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"","text_display":""},{"cnt":[[453,1960],[1810,1960],[1810,1992],[453,1992]],"region":{"top_left_x":453,"top_left_y":1960,"width":1358,"height":32},"line":13,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f649e84e974941cca96cfefc60e0c369","type":"table_row","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"","text_display":""},{"cnt":[[476,619],[502,619],[502,651],[476,651]],"region":{"top_left_x":476,"top_left_y":619,"width":27,"height":32},"line":14,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3474624551f248f09e36c722befaf708","type":"simple_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"8","text_display":"8","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.994140625,"confidence_rate":0.994140625},{"cnt":[[529,531],[1198,531],[1198,750],[529,750]],"region":{"top_left_x":529,"top_left_y":530,"width":669,"height":221},"line":15,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e638ed25423145bfbfa3935d224daba4","type":"complex_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","children_ids":["1d684a39c03f42c19d2ba39cb061d844","12231a0824ef45998c1498435110188e","269bac86e97545cdae2fb118cc574ee5","67f49ed2d9574f39ba2662b041f0dc3c","eacbf11f526b42efbe42c23c5095af12","97442366031d4c7dba09d7ae7e56d809","b126bc1c13134399b25c2e499d2b4c29","fdbd1ec8149c4346819ce44208262e7f","4399a40c090a479f9e3e032e66eadabe"],"text":"\\begin{tabular}{l}\n(3) Visual \\\\\nVIsual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, out if they look at the side of the moving fingers appropitately, this can be scored as normal. If there Is unliateral bilndness or enucleaton, visual flelds in the remaining eye are scored. Score 1 only if a clear-cut asymmetry, Including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous stimulation is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22 . Score as examined, using bilateral threat.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(3) Visual \\\\\nVIsual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, out if they look at the side of the moving fingers appropitately, this can be scored as normal. If there Is unliateral bilndness or enucleaton, visual flelds in the remaining eye are scored. Score 1 only if a clear-cut asymmetry, Including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous stimulation is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22 . Score as examined, using bilateral threat.\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.03578945687643408,"confidence_rate":0.9888906398978672},{"cnt":[[810,534],[917,534],[917,561],[810,561]],"region":{"top_left_x":810,"top_left_y":533,"width":107,"height":28},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1d684a39c03f42c19d2ba39cb061d844","type":"text","conversion_output":false,"parent_id":"e638ed25423145bfbfa3935d224daba4","text":"(3) Visual","text_display":"(3) Visual","confidence":1,"confidence_rate":1},{"cnt":[[532,580],[1180,580],[1180,603],[532,603]],"region":{"top_left_x":532,"top_left_y":579,"width":649,"height":25},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"12231a0824ef45998c1498435110188e","type":"text","conversion_output":false,"parent_id":"e638ed25423145bfbfa3935d224daba4","text":"VIsual fields (upper and lower quadrants) are tested by confrontation, using finger","text_display":"\nVIsual fields (upper and lower quadrants) are tested by confrontation, using finger","confidence":0.31461687121030146,"confidence_rate":0.9869450594785775},{"cnt":[[532,602],[1166,602],[1166,624],[532,624]],"region":{"top_left_x":532,"top_left_y":601,"width":635,"height":23},"line":18,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"269bac86e97545cdae2fb118cc574ee5","type":"text","conversion_output":false,"parent_id":"e638ed25423145bfbfa3935d224daba4","text":"counting or wsual threat as appropriate. Patient must be encouraged, out if they","text_display":" counting or wsual threat as appropriate. Patient must be encouraged, out if they","confidence":0.03578945687643408,"confidence_rate":0.961579850307281},{"cnt":[[532,621],[1194,621],[1194,644],[532,644]],"region":{"top_left_x":532,"top_left_y":620,"width":662,"height":25},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"67f49ed2d9574f39ba2662b041f0dc3c","type":"text","conversion_output":false,"parent_id":"e638ed25423145bfbfa3935d224daba4","text":"look at the side of the moving fingers appropitately, this can be scored as normal. If","text_display":" look at the side of the moving fingers appropitately, this can be scored as normal. If","confidence":0.7470054804256537,"confidence_rate":0.99679982648078},{"cnt":[[532,640],[1169,640],[1169,663],[532,663]],"region":{"top_left_x":532,"top_left_y":639,"width":638,"height":25},"line":20,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"eacbf11f526b42efbe42c23c5095af12","type":"text","conversion_output":false,"parent_id":"e638ed25423145bfbfa3935d224daba4","text":"there Is unliateral bilndness or enucleaton, visual flelds in the remaining eye are","text_display":" there Is unliateral bilndness or enucleaton, visual flelds in the remaining eye are","confidence":0.3959534508729845,"confidence_rate":0.9895272858807558},{"cnt":[[532,662],[1192,662],[1192,686],[532,686]],"region":{"top_left_x":532,"top_left_y":661,"width":661,"height":26},"line":21,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"97442366031d4c7dba09d7ae7e56d809","type":"text","conversion_output":false,"parent_id":"e638ed25423145bfbfa3935d224daba4","text":"scored. Score 1 only if a clear-cut asymmetry, Including quadrantanopla is found. If","text_display":" scored. Score 1 only if a clear-cut asymmetry, Including quadrantanopla is found. If","confidence":0.224573483851611,"confidence_rate":0.9838968012936737},{"cnt":[[532,684],[1126,684],[1126,707],[532,707]],"region":{"top_left_x":532,"top_left_y":683,"width":594,"height":24},"line":22,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b126bc1c13134399b25c2e499d2b4c29","type":"text","conversion_output":false,"parent_id":"e638ed25423145bfbfa3935d224daba4","text":"patent is bilnd from any cause score 3. Double simultaneous stimulation is","text_display":" patent is bilnd from any cause score 3. Double simultaneous stimulation is","confidence":0.3454624252561709,"confidence_rate":0.98663603313885},{"cnt":[[532,703],[1191,703],[1191,726],[532,726]],"region":{"top_left_x":532,"top_left_y":702,"width":660,"height":24},"line":23,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fdbd1ec8149c4346819ce44208262e7f","type":"text","conversion_output":false,"parent_id":"e638ed25423145bfbfa3935d224daba4","text":"performed at this point. If there is extinction patient recelves a 1 and the results are","text_display":" performed at this point. If there is extinction patient recelves a 1 and the results are","confidence":0.8259984111238435,"confidence_rate":0.9980107059708404},{"cnt":[[532,722],[1104,722],[1104,748],[532,748]],"region":{"top_left_x":532,"top_left_y":721,"width":572,"height":27},"line":24,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4399a40c090a479f9e3e032e66eadabe","type":"text","conversion_output":false,"parent_id":"e638ed25423145bfbfa3935d224daba4","text":"used to answer question 22 . Score as examined, using bilateral threat.","text_display":" used to answer question 22 . Score as examined, using bilateral threat.","confidence":0.8007751679979265,"confidence_rate":0.9971916083932044},{"cnt":[[1200,538],[1769,536],[1770,715],[1201,716]],"region":{"top_left_x":1200,"top_left_y":536,"width":570,"height":181},"line":25,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c0491e09534d42b8ab6060474057cfd2","type":"complex_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","children_ids":["47930228441443fa83104c8a0c48bf82","0a1c96f076f8435790ea35cbab37370e","c8bc9b2768f64c4fb297985b16c3e589","854710bec67c4cd5922fcf4bac263ad3","a774fe91b9fd456b8cce4ea2ef4305fe","7c5e2af5ff624720ae6c1d9b634143d6","b6f58686a42b431c8d733e7aeedcc11e","d84441c4157e47bcbcf91f11b574da82"],"text":"◯ 0=No visual loss\n◯ 1 =Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral hemianopia (blind including cortical blindness)","text_display":"◯ 0=No visual loss\n◯ 1 =Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral hemianopia (blind including cortical blindness)","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.4681062698364258,"confidence_rate":0.9918709375893656},{"cnt":[[1203,542],[1240,542],[1240,576],[1203,576]],"region":{"top_left_x":1203,"top_left_y":541,"width":38,"height":35},"line":26,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"47930228441443fa83104c8a0c48bf82","type":"form_field","conversion_output":false,"parent_id":"c0491e09534d42b8ab6060474057cfd2","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1241,553],[1396,553],[1396,579],[1241,579]],"region":{"top_left_x":1241,"top_left_y":552,"width":155,"height":27},"line":27,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0a1c96f076f8435790ea35cbab37370e","type":"text","conversion_output":false,"parent_id":"c0491e09534d42b8ab6060474057cfd2","text":"0=No visual loss","text_display":" 0=No visual loss","confidence":0.9531133342534304,"confidence_rate":0.9977158764591045},{"cnt":[[1203,588],[1240,588],[1240,621],[1203,621]],"region":{"top_left_x":1203,"top_left_y":588,"width":38,"height":33},"line":28,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c8bc9b2768f64c4fb297985b16c3e589","type":"form_field","conversion_output":false,"parent_id":"c0491e09534d42b8ab6060474057cfd2","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1244,596],[1438,596],[1438,625],[1244,625]],"region":{"top_left_x":1244,"top_left_y":596,"width":194,"height":29},"line":29,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"854710bec67c4cd5922fcf4bac263ad3","type":"text","conversion_output":false,"parent_id":"c0491e09534d42b8ab6060474057cfd2","text":"1 =Partial hemianopia","text_display":" 1 =Partial hemianopia","confidence":0.4681062698364258,"confidence_rate":0.9700939102680134},{"cnt":[[1203,629],[1240,629],[1240,663],[1203,663]],"region":{"top_left_x":1203,"top_left_y":629,"width":38,"height":35},"line":30,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a774fe91b9fd456b8cce4ea2ef4305fe","type":"form_field","conversion_output":false,"parent_id":"c0491e09534d42b8ab6060474057cfd2","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1241,640],[1469,640],[1469,669],[1241,669]],"region":{"top_left_x":1241,"top_left_y":639,"width":229,"height":30},"line":31,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7c5e2af5ff624720ae6c1d9b634143d6","type":"text","conversion_output":false,"parent_id":"c0491e09534d42b8ab6060474057cfd2","text":"2=Complete hemianopia","text_display":" 2=Complete hemianopia","confidence":1,"confidence_rate":1},{"cnt":[[1203,673],[1240,673],[1240,708],[1203,708]],"region":{"top_left_x":1203,"top_left_y":672,"width":38,"height":37},"line":32,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b6f58686a42b431c8d733e7aeedcc11e","type":"form_field","conversion_output":false,"parent_id":"c0491e09534d42b8ab6060474057cfd2","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1241,684],[1764,684],[1764,712],[1241,712]],"region":{"top_left_x":1241,"top_left_y":683,"width":523,"height":30},"line":33,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d84441c4157e47bcbcf91f11b574da82","type":"text","conversion_output":false,"parent_id":"c0491e09534d42b8ab6060474057cfd2","text":"3=Bilateral hemianopia (blind including cortical blindness)","text_display":" 3=Bilateral hemianopia (blind including cortical blindness)","confidence":1,"confidence_rate":1},{"cnt":[[486,905],[502,905],[502,940],[486,940]],"region":{"top_left_x":485,"top_left_y":904,"width":18,"height":37},"line":34,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1473554c598642cebcc31da39c99a116","type":"simple_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"7","text_display":"7","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[527,906],[1188,906],[1188,1023],[527,1023]],"region":{"top_left_x":526,"top_left_y":905,"width":663,"height":119},"line":35,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"eeccca4a84d64021b3de4bda8a58a578","type":"complex_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","children_ids":["bc6bd389c17e4ffea3c1862e53c0e25e","a4c1ba9777eb4aeebe2a9c6be8fbc8ff","a731a8302d684ccdb236e5c6547fffa1","669c818b40df4bbf951673e45d1e6b29","85c4fa5bf3574af89f5e53ac9a1429b8"],"text":"Ask, or use pantomime to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responslve or non-comprehending patent. If facial traumalbandages, orotracheal tude, tape or other physical barrier obscures the face, these should be removed to the extent possible. Coma Score \" 3 \".","text_display":"Ask, or use pantomime to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responslve or non-comprehending patent. If facial traumalbandages, orotracheal tude, tape or other physical barrier obscures the face, these should be removed to the extent possible. Coma Score \" 3 \".","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.3474222018073339,"confidence_rate":0.991800995562259},{"cnt":[[532,910],[1175,910],[1175,936],[532,936]],"region":{"top_left_x":532,"top_left_y":910,"width":643,"height":26},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bc6bd389c17e4ffea3c1862e53c0e25e","type":"text","conversion_output":false,"parent_id":"eeccca4a84d64021b3de4bda8a58a578","text":"Ask, or use pantomime to encourage the patient to show teeth or raise eyebrows","text_display":"Ask, or use pantomime to encourage the patient to show teeth or raise eyebrows","confidence":0.9723430547519456,"confidence_rate":0.9996621462444537},{"cnt":[[532,932],[1172,932],[1172,955],[532,955]],"region":{"top_left_x":532,"top_left_y":931,"width":640,"height":25},"line":37,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a4c1ba9777eb4aeebe2a9c6be8fbc8ff","type":"text","conversion_output":false,"parent_id":"eeccca4a84d64021b3de4bda8a58a578","text":"and close eyes. Score symmetry of grimace in response to noxlous stimull in the","text_display":" and close eyes. Score symmetry of grimace in response to noxlous stimull in the","confidence":0.5133618964191555,"confidence_rate":0.9920936325808101},{"cnt":[[532,951],[1136,951],[1136,976],[532,976]],"region":{"top_left_x":532,"top_left_y":950,"width":605,"height":26},"line":38,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a731a8302d684ccdb236e5c6547fffa1","type":"text","conversion_output":false,"parent_id":"eeccca4a84d64021b3de4bda8a58a578","text":"poorly responslve or non-comprehending patent. If facial traumalbandages,","text_display":" poorly responslve or non-comprehending patent. If facial traumalbandages,","confidence":0.3474222018073339,"confidence_rate":0.9865374100007495},{"cnt":[[532,973],[1186,973],[1186,997],[532,997]],"region":{"top_left_x":532,"top_left_y":972,"width":654,"height":26},"line":39,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"669c818b40df4bbf951673e45d1e6b29","type":"text","conversion_output":false,"parent_id":"eeccca4a84d64021b3de4bda8a58a578","text":"orotracheal tude, tape or other physical barrier obscures the face, these should be","text_display":" orotracheal tude, tape or other physical barrier obscures the face, these should be","confidence":0.412064145231955,"confidence_rate":0.9899758499833191},{"cnt":[[532,993],[926,993],[926,1018],[532,1018]],"region":{"top_left_x":532,"top_left_y":993,"width":395,"height":25},"line":40,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"85c4fa5bf3574af89f5e53ac9a1429b8","type":"text","conversion_output":false,"parent_id":"eeccca4a84d64021b3de4bda8a58a578","text":"removed to the extent possible. Coma Score \" 3 \".","text_display":" removed to the extent possible. Coma Score \" 3 \".","confidence":0.5899048620490588,"confidence_rate":0.9907831936030872},{"cnt":[[1201,819],[1797,819],[1797,1045],[1201,1045]],"region":{"top_left_x":1200,"top_left_y":818,"width":597,"height":228},"line":41,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e2f1627b0fde4fc9b6425938b4e42b81","type":"complex_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","children_ids":["bd54aa2f3d20414c99c139d0fa7b8145","4abdda6da4914a57b28e415885ae30d0","f4513fbe1f3346faa45bbaa3cbb1e803","3a65e050f2c1401fabd5d9d628399205","e3c5ae70cfe44f8b93c70f5bc29074ec","efaf38f580744fbd8844a2d5e382ea0b","9ec5addbc9ec4cb5844c3cdbd659ad1f","8994bfba5cf1428d8ac1170f876f1674","96b3ffe4b1e94566b05ebe3ccb74196d","cf97714746f94f998d5532515252ca77"],"text":"◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face)","text_display":"◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face)","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.7255766115506268,"confidence_rate":0.9983676086623965},{"cnt":[[1203,823],[1240,823],[1240,857],[1203,857]],"region":{"top_left_x":1203,"top_left_y":822,"width":38,"height":35},"line":42,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bd54aa2f3d20414c99c139d0fa7b8145","type":"form_field","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1241,832],[1551,832],[1551,861],[1241,861]],"region":{"top_left_x":1241,"top_left_y":832,"width":311,"height":29},"line":43,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4abdda6da4914a57b28e415885ae30d0","type":"text","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"0=Normal symmetrical movement","text_display":" 0=Normal symmetrical movement","confidence":0.7255766115506268,"confidence_rate":0.9906094103425399},{"cnt":[[1203,866],[1240,866],[1240,903],[1203,903]],"region":{"top_left_x":1203,"top_left_y":866,"width":38,"height":38},"line":44,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f4513fbe1f3346faa45bbaa3cbb1e803","type":"form_field","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1241,876],[1767,876],[1767,906],[1241,906]],"region":{"top_left_x":1241,"top_left_y":875,"width":526,"height":31},"line":45,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3a65e050f2c1401fabd5d9d628399205","type":"text","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"\\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of","text_display":" \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of","confidence":0.9848952172324061,"confidence_rate":0.9997584415305353},{"cnt":[[1269,905],[1349,905],[1349,933],[1269,933]],"region":{"top_left_x":1268,"top_left_y":904,"width":82,"height":30},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e3c5ae70cfe44f8b93c70f5bc29074ec","type":"text","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"smiling)","text_display":" smiling)","confidence":1,"confidence_rate":1},{"cnt":[[1203,932],[1237,932],[1237,969],[1203,969]],"region":{"top_left_x":1203,"top_left_y":931,"width":35,"height":38},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"efaf38f580744fbd8844a2d5e382ea0b","type":"form_field","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1239,943],[1793,943],[1793,971],[1239,971]],"region":{"top_left_x":1238,"top_left_y":942,"width":555,"height":30},"line":48,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9ec5addbc9ec4cb5844c3cdbd659ad1f","type":"text","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"2=Partial paralysis (total or near total paralysis of lower face)","text_display":" 2=Partial paralysis (total or near total paralysis of lower face)","confidence":0.99853515625,"confidence_rate":0.999979058538097},{"cnt":[[1203,978],[1237,978],[1237,1012],[1203,1012]],"region":{"top_left_x":1203,"top_left_y":978,"width":35,"height":35},"line":49,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8994bfba5cf1428d8ac1170f876f1674","type":"form_field","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1240,986],[1793,986],[1793,1015],[1240,1015]],"region":{"top_left_x":1240,"top_left_y":986,"width":553,"height":30},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"96b3ffe4b1e94566b05ebe3ccb74196d","type":"text","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"3=Complete paralysis of one or both sides (absence of facial","text_display":" 3=Complete paralysis of one or both sides (absence of facial","confidence":1,"confidence_rate":1},{"cnt":[[1261,1014],[1622,1014],[1622,1041],[1261,1041]],"region":{"top_left_x":1260,"top_left_y":1013,"width":363,"height":29},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cf97714746f94f998d5532515252ca77","type":"text","conversion_output":false,"parent_id":"e2f1627b0fde4fc9b6425938b4e42b81","text":"movement in the upper and lower face)","text_display":" movement in the upper and lower face)","confidence":0.99560546875,"confidence_rate":0.9998951432220243},{"cnt":[[475,1262],[502,1262],[502,1288],[475,1288]],"region":{"top_left_x":474,"top_left_y":1262,"width":29,"height":26},"line":52,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f40e8755283448b0a67cbaad7e60a8ca","type":"simple_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"8","text_display":"8","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[531,1164],[1194,1164],[1194,1383],[531,1383]],"region":{"top_left_x":530,"top_left_y":1163,"width":664,"height":221},"line":53,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"31a9effe918a46dab99d753aedefdf04","type":"complex_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","children_ids":["62678a5e1e2b49818e7ea6a9a5f4360d","14118f63df7245788c6f2366cb54bf12","d971225b19d9422bb08e64328da6e1d1","64b0f2dba67b4dbbbeb1f20c01c3c8d2","9e30793697044182bf0a8ef84bb8caef","b17faac59746424d887efb2666edbe41","3b500010febb42ea9188b8fa8546045a","70cf6e08d98347d18fbfd3cb66f54b3e","5df8f839bed94cd58ce66b28ad97c92f"],"text":"\\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (ir sitting) or 45 degrees (ir supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shouder or hip can the examiner indicate no score and an explanation must be provided. Coma Score \" 4 \".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (ir sitting) or 45 degrees (ir supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shouder or hip can the examiner indicate no score and an explanation must be provided. Coma Score \" 4 \".\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.3139467074944053,"confidence_rate":0.9961706505417118},{"cnt":[[769,1167],[959,1167],[959,1198],[769,1198]],"region":{"top_left_x":769,"top_left_y":1166,"width":191,"height":32},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"62678a5e1e2b49818e7ea6a9a5f4360d","type":"text","conversion_output":false,"parent_id":"31a9effe918a46dab99d753aedefdf04","text":"(5a) Motor Arm Left","text_display":"(5a) Motor Arm Left","confidence":0.9630219382233918,"confidence_rate":0.9984312698156119},{"cnt":[[544,1213],[1180,1213],[1180,1239],[544,1239]],"region":{"top_left_x":544,"top_left_y":1212,"width":637,"height":27},"line":55,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"14118f63df7245788c6f2366cb54bf12","type":"text","conversion_output":false,"parent_id":"31a9effe918a46dab99d753aedefdf04","text":"The limb is placed in the appropriate position: extend the arms (paims down) 90","text_display":"\nThe limb is placed in the appropriate position: extend the arms (paims down) 90","confidence":0.8848388543551822,"confidence_rate":0.9985269927365716},{"cnt":[[536,1235],[1188,1235],[1188,1261],[536,1261]],"region":{"top_left_x":536,"top_left_y":1234,"width":653,"height":27},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d971225b19d9422bb08e64328da6e1d1","type":"text","conversion_output":false,"parent_id":"31a9effe918a46dab99d753aedefdf04","text":"degrees (ir sitting) or 45 degrees (ir supine) and the leg 30 degrees (always tested","text_display":" degrees (ir sitting) or 45 degrees (ir supine) and the leg 30 degrees (always tested","confidence":0.3139467074944053,"confidence_rate":0.9878789845714966},{"cnt":[[559,1257],[1166,1257],[1166,1280],[559,1280]],"region":{"top_left_x":559,"top_left_y":1256,"width":608,"height":24},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"64b0f2dba67b4dbbbeb1f20c01c3c8d2","type":"text","conversion_output":false,"parent_id":"31a9effe918a46dab99d753aedefdf04","text":"supine). Drift is scored if the arm falls before 10 seconds or the leg before 5","text_display":" supine). Drift is scored if the arm falls before 10 seconds or the leg before 5","confidence":0.7208003575689422,"confidence_rate":0.9962003408033016},{"cnt":[[559,1276],[1166,1276],[1166,1299],[559,1299]],"region":{"top_left_x":559,"top_left_y":1275,"width":608,"height":24},"line":58,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9e30793697044182bf0a8ef84bb8caef","type":"text","conversion_output":false,"parent_id":"31a9effe918a46dab99d753aedefdf04","text":"seconds. The aphasic patient is encouraged using urgency in the volce and","text_display":" seconds. The aphasic patient is encouraged using urgency in the volce and","confidence":0.8163285255432129,"confidence_rate":0.9974016073198311},{"cnt":[[536,1295],[1188,1295],[1188,1321],[536,1321]],"region":{"top_left_x":536,"top_left_y":1294,"width":653,"height":27},"line":59,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b17faac59746424d887efb2666edbe41","type":"text","conversion_output":false,"parent_id":"31a9effe918a46dab99d753aedefdf04","text":"pantomime but not noxious stimulation. Each imb is tested in tum, beginning with","text_display":" pantomime but not noxious stimulation. Each imb is tested in tum, beginning with","confidence":0.8066402237607063,"confidence_rate":0.9974752216923889},{"cnt":[[536,1317],[1188,1317],[1188,1343],[536,1343]],"region":{"top_left_x":536,"top_left_y":1316,"width":653,"height":27},"line":60,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3b500010febb42ea9188b8fa8546045a","type":"text","conversion_output":false,"parent_id":"31a9effe918a46dab99d753aedefdf04","text":"the non-paretic arm. Only in cases of amputation or joint fusion at the shouder or","text_display":" the non-paretic arm. Only in cases of amputation or joint fusion at the shouder or","confidence":0.6023705215752753,"confidence_rate":0.9941907035228359},{"cnt":[[555,1338],[1171,1338],[1171,1362],[555,1362]],"region":{"top_left_x":555,"top_left_y":1338,"width":616,"height":24},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"70cf6e08d98347d18fbfd3cb66f54b3e","type":"text","conversion_output":false,"parent_id":"31a9effe918a46dab99d753aedefdf04","text":"hip can the examiner indicate no score and an explanation must be provided.","text_display":" hip can the examiner indicate no score and an explanation must be provided.","confidence":0.99560546875,"confidence_rate":0.99994494882056},{"cnt":[[794,1358],[932,1358],[932,1379],[794,1379]],"region":{"top_left_x":794,"top_left_y":1357,"width":138,"height":23},"line":62,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5df8f839bed94cd58ce66b28ad97c92f","type":"text","conversion_output":false,"parent_id":"31a9effe918a46dab99d753aedefdf04","text":"Coma Score \" 4 \".","text_display":" Coma Score \" 4 \".","confidence":0.8941953130791854,"confidence_rate":0.9955367477801047},{"cnt":[[1200,1122],[1797,1120],[1798,1433],[1201,1435]],"region":{"top_left_x":1200,"top_left_y":1120,"width":599,"height":315},"line":63,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0ca21065e49642fd9683ed876550f607","type":"complex_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","children_ids":["2af22ee52c3a466cb7624bee98aa7c7f","deee3a302ffe448cb107f41d29f926b5","6d0516adf6cd470b9a2785709981bf06","22c0b99c70464df8b2162f10076ca2a9","a58d46854440448792ec81be8f899460","64987e30cd42402eb758a18160c2906c","f6f2265a8cf54773baf96ae9408d6a64","08cf60ffdb9f4375984bebe3b7445b92","f478abbf856740ebaeb1a2b5baf0ed84","5aad5ad37808479e879676b1cef2d7e6","039521600592450c8d62fdea7ca3e39d","aec9e1c610734a7b957a1c5e4a568a24","f309475b67e34011b67d1476adbf6a49","148a35582e834e618333516eed02a21e"],"text":"◯ 0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion","text_display":"◯ 0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.40634400691009764,"confidence_rate":0.9921677612051699},{"cnt":[[1203,1123],[1240,1123],[1240,1160],[1203,1160]],"region":{"top_left_x":1203,"top_left_y":1122,"width":38,"height":38},"line":64,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2af22ee52c3a466cb7624bee98aa7c7f","type":"form_field","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1241,1134],[1783,1134],[1783,1162],[1241,1162]],"region":{"top_left_x":1241,"top_left_y":1133,"width":543,"height":30},"line":65,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"deee3a302ffe448cb107f41d29f926b5","type":"text","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds","text_display":" 0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds","confidence":0.40634400691009764,"confidence_rate":0.9875701856059609},{"cnt":[[1203,1169],[1240,1169],[1240,1203],[1203,1203]],"region":{"top_left_x":1203,"top_left_y":1169,"width":38,"height":35},"line":66,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6d0516adf6cd470b9a2785709981bf06","type":"form_field","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1241,1177],[1791,1177],[1791,1209],[1241,1209]],"region":{"top_left_x":1241,"top_left_y":1177,"width":551,"height":32},"line":67,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"22c0b99c70464df8b2162f10076ca2a9","type":"text","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"\\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before","text_display":" \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before","confidence":0.9873106479644775,"confidence_rate":0.9998175802192296},{"cnt":[[1247,1205],[1548,1205],[1548,1233],[1247,1233]],"region":{"top_left_x":1246,"top_left_y":1204,"width":303,"height":30},"line":68,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a58d46854440448792ec81be8f899460","type":"text","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"full 10 seconds; does not hit bed","text_display":" full 10 seconds; does not hit bed","confidence":1,"confidence_rate":1},{"cnt":[[1203,1235],[1237,1235],[1237,1272],[1203,1272]],"region":{"top_left_x":1203,"top_left_y":1234,"width":35,"height":38},"line":69,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"64987e30cd42402eb758a18160c2906c","type":"form_field","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1240,1246],[1790,1246],[1790,1274],[1240,1274]],"region":{"top_left_x":1240,"top_left_y":1245,"width":550,"height":30},"line":70,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f6f2265a8cf54773baf96ae9408d6a64","type":"text","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"2=Some effort against gravity, limb cannot get to or maintain","text_display":" 2=Some effort against gravity, limb cannot get to or maintain","confidence":1,"confidence_rate":1},{"cnt":[[1250,1273],[1437,1273],[1437,1302],[1250,1302]],"region":{"top_left_x":1249,"top_left_y":1272,"width":188,"height":30},"line":71,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"08cf60ffdb9f4375984bebe3b7445b92","type":"text","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"(if cued) 90 degrees","text_display":" (if cued) 90 degrees","confidence":0.474090576171875,"confidence_rate":0.9736965218578639},{"cnt":[[1206,1303],[1240,1303],[1240,1337],[1206,1337]],"region":{"top_left_x":1206,"top_left_y":1302,"width":35,"height":36},"line":72,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f478abbf856740ebaeb1a2b5baf0ed84","type":"form_field","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1241,1311],[1576,1311],[1576,1343],[1241,1343]],"region":{"top_left_x":1241,"top_left_y":1311,"width":335,"height":32},"line":73,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5aad5ad37808479e879676b1cef2d7e6","type":"text","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"3=No effort against gravity, limb fails","text_display":" 3=No effort against gravity, limb fails","confidence":0.9965846532722935,"confidence_rate":0.9999222486514747},{"cnt":[[1206,1347],[1240,1347],[1240,1381],[1206,1381]],"region":{"top_left_x":1206,"top_left_y":1346,"width":35,"height":35},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"039521600592450c8d62fdea7ca3e39d","type":"form_field","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1239,1358],[1398,1358],[1398,1383],[1239,1383]],"region":{"top_left_x":1238,"top_left_y":1357,"width":161,"height":27},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"aec9e1c610734a7b957a1c5e4a568a24","type":"text","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"4=No movement","text_display":" 4=No movement","confidence":0.6553018775302917,"confidence_rate":0.9767924647522122},{"cnt":[[1206,1390],[1240,1390],[1240,1427],[1206,1427]],"region":{"top_left_x":1206,"top_left_y":1390,"width":35,"height":38},"line":76,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f309475b67e34011b67d1476adbf6a49","type":"form_field","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1240,1401],[1458,1401],[1458,1430],[1240,1430]],"region":{"top_left_x":1240,"top_left_y":1401,"width":219,"height":29},"line":77,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"148a35582e834e618333516eed02a21e","type":"text","conversion_output":false,"parent_id":"0ca21065e49642fd9683ed876550f607","text":"Amputation, joint fusion","text_display":" Amputation, joint fusion","confidence":1,"confidence_rate":1},{"cnt":[[475,1486],[502,1486],[502,1510],[475,1510]],"region":{"top_left_x":474,"top_left_y":1485,"width":29,"height":26},"line":78,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"37d1f9b8f57b49338c6547206203e4ba","type":"simple_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"9","text_display":"9","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[712,1486],[1196,1486],[1196,1516],[712,1516]],"region":{"top_left_x":712,"top_left_y":1485,"width":485,"height":31},"line":79,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e363ec3f122c41b6beda127412408446","type":"simple_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"Explain if amputation or joint fusion (Motor Arm Left):","text_display":"Explain if amputation or joint fusion (Motor Arm Left):","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[475,1729],[510,1729],[510,1753],[475,1753]],"region":{"top_left_x":474,"top_left_y":1728,"width":37,"height":26},"line":80,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"55f4e409ed064a7487e6d4af0a38de4e","type":"simple_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"10","text_display":"10","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[532,1630],[1194,1630],[1194,1853],[532,1853]],"region":{"top_left_x":532,"top_left_y":1630,"width":662,"height":223},"line":81,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6cef5d91458d4bf39c40df92125e68c7","type":"complex_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","children_ids":["e605619dbb124c9c990d1ea41e78fe05","e6b8a45c6d474f0fb34fea15362df208","a4c5bae5d6a74788a16bc96bd5e886a5","24c49f8a74bf484289765c08d3e31631","31ad60abac4e4c47a52eb649500d73f4","ba85850bd2ae4fc2a2651f8f4e657b28","c555eec6f186419ca36e030c7eccd3e1","665957646c064a528322447bd372bd18","28607cb970b4405b85a3ef34b6e0d043"],"text":"\\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm tals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm tals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.3328499393232001,"confidence_rate":0.9943136699459194},{"cnt":[[761,1634],[967,1634],[967,1663],[761,1663]],"region":{"top_left_x":761,"top_left_y":1634,"width":207,"height":30},"line":82,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e605619dbb124c9c990d1ea41e78fe05","type":"text","conversion_output":false,"parent_id":"6cef5d91458d4bf39c40df92125e68c7","text":"(5b) Motor Amm Right","text_display":"(5b) Motor Amm Right","confidence":0.900390625,"confidence_rate":0.995811732079183},{"cnt":[[544,1681],[1180,1681],[1180,1705],[544,1705]],"region":{"top_left_x":544,"top_left_y":1680,"width":637,"height":26},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e6b8a45c6d474f0fb34fea15362df208","type":"text","conversion_output":false,"parent_id":"6cef5d91458d4bf39c40df92125e68c7","text":"The limb is placed in the appropriate position: extend the arms (paims down) 90","text_display":"\nThe limb is placed in the appropriate position: extend the arms (paims down) 90","confidence":0.3328499393232001,"confidence_rate":0.9868336671693375},{"cnt":[[538,1701],[1188,1701],[1188,1727],[538,1727]],"region":{"top_left_x":537,"top_left_y":1701,"width":652,"height":27},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a4c5bae5d6a74788a16bc96bd5e886a5","type":"text","conversion_output":false,"parent_id":"6cef5d91458d4bf39c40df92125e68c7","text":"degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested","text_display":" degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested","confidence":0.5842906013131142,"confidence_rate":0.9943595797145227},{"cnt":[[559,1724],[1166,1724],[1166,1749],[559,1749]],"region":{"top_left_x":559,"top_left_y":1724,"width":608,"height":26},"line":85,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"24c49f8a74bf484289765c08d3e31631","type":"text","conversion_output":false,"parent_id":"6cef5d91458d4bf39c40df92125e68c7","text":"supine). Drift is scored if the arm tals before 10 seconds or the leg before 5","text_display":" supine). Drift is scored if the arm tals before 10 seconds or the leg before 5","confidence":0.5078499392560327,"confidence_rate":0.9920602842018874},{"cnt":[[559,1745],[1166,1745],[1166,1768],[559,1768]],"region":{"top_left_x":559,"top_left_y":1744,"width":608,"height":25},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"31ad60abac4e4c47a52eb649500d73f4","type":"text","conversion_output":false,"parent_id":"6cef5d91458d4bf39c40df92125e68c7","text":"seconds. The aphasic patient is encouraged using urgency in the volce and","text_display":" seconds. The aphasic patient is encouraged using urgency in the volce and","confidence":0.9844028784459624,"confidence_rate":0.9997984813792954},{"cnt":[[535,1764],[1188,1764],[1188,1790],[535,1790]],"region":{"top_left_x":534,"top_left_y":1764,"width":655,"height":26},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ba85850bd2ae4fc2a2651f8f4e657b28","type":"text","conversion_output":false,"parent_id":"6cef5d91458d4bf39c40df92125e68c7","text":"pantomime but not noxious stimulation. Each imb is tested in turn, beginning with","text_display":" pantomime but not noxious stimulation. Each imb is tested in turn, beginning with","confidence":0.7567621688587356,"confidence_rate":0.9967644752700966},{"cnt":[[536,1783],[1190,1783],[1190,1809],[536,1809]],"region":{"top_left_x":536,"top_left_y":1783,"width":654,"height":27},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c555eec6f186419ca36e030c7eccd3e1","type":"text","conversion_output":false,"parent_id":"6cef5d91458d4bf39c40df92125e68c7","text":"the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or","text_display":" the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or","confidence":0.5471648236915976,"confidence_rate":0.9931710918867311},{"cnt":[[555,1805],[1171,1805],[1171,1831],[555,1831]],"region":{"top_left_x":555,"top_left_y":1804,"width":616,"height":27},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"665957646c064a528322447bd372bd18","type":"text","conversion_output":false,"parent_id":"6cef5d91458d4bf39c40df92125e68c7","text":"hip can the examiner indicate no score and an explanation must be provided.","text_display":" hip can the examiner indicate no score and an explanation must be provided.","confidence":0.9428542390439577,"confidence_rate":0.9992647256988562},{"cnt":[[794,1827],[930,1827],[930,1850],[794,1850]],"region":{"top_left_x":794,"top_left_y":1826,"width":137,"height":24},"line":90,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"28607cb970b4405b85a3ef34b6e0d043","type":"text","conversion_output":false,"parent_id":"6cef5d91458d4bf39c40df92125e68c7","text":"Coma score \"4\".","text_display":" Coma score \"4\".","confidence":0.8316993713378906,"confidence_rate":0.9908281089664356},{"cnt":[[1201,1589],[1797,1589],[1797,1899],[1201,1899]],"region":{"top_left_x":1200,"top_left_y":1589,"width":597,"height":311},"line":91,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"733a6a4aa5a9435699c76a2df82605c9","type":"complex_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","children_ids":["2f7ba8deca1348b5ac1d65c034fbf60d","4ae25643aebf41e2bcad3bd1a5a6ecbb","d89fa2387b3e4fa98c6f977cce461352","5e0c4d56a4d94ce6ba5a35bae5bd180c","9d6232cf251c456281b419f584252770","9d9efd7a0cd84bc29c15936ad37dc206","4516ef82c60f43ceaac02a80e9d61a12","fe3bad1d6cf240f7a9b2bcda8aa523a2","fc08592ec0d544dbb76a58de6d5b18cc","795686935b6d4854b0ccf5aea70e9a0f","86f5d9da62534c9497eb1c44bf13c7fc","af827baf66c743e284dfb930600492d1","ea196089f9594144b3e3904519355d43","2edbbad3618347b9a99ee8f11e7eb31c"],"text":"◯ 0 =No drift, limb holds 90 (or 45 ) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint fusion","text_display":"◯ 0 =No drift, limb holds 90 (or 45 ) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint 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full 10 seconds","confidence":0.431471381438314,"confidence_rate":0.9890010137935048},{"cnt":[[1203,1636],[1240,1636],[1240,1670],[1203,1670]],"region":{"top_left_x":1203,"top_left_y":1635,"width":38,"height":35},"line":94,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d89fa2387b3e4fa98c6f977cce461352","type":"form_field","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1241,1645],[1790,1645],[1790,1673],[1241,1673]],"region":{"top_left_x":1241,"top_left_y":1645,"width":549,"height":28},"line":95,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5e0c4d56a4d94ce6ba5a35bae5bd180c","type":"text","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"\\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before","text_display":" \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before","confidence":0.9297215938568115,"confidence_rate":0.998959540238336},{"cnt":[[1247,1671],[1548,1671],[1548,1700],[1247,1700]],"region":{"top_left_x":1246,"top_left_y":1671,"width":303,"height":29},"line":96,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9d6232cf251c456281b419f584252770","type":"text","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"full 10 seconds; does not hit bed","text_display":" full 10 seconds; does not hit bed","confidence":0.99609375,"confidence_rate":0.9999045435972003},{"cnt":[[1203,1701],[1237,1701],[1237,1738],[1203,1738]],"region":{"top_left_x":1203,"top_left_y":1701,"width":35,"height":38},"line":97,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9d9efd7a0cd84bc29c15936ad37dc206","type":"form_field","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1240,1712],[1790,1712],[1790,1741],[1240,1741]],"region":{"top_left_x":1240,"top_left_y":1712,"width":550,"height":29},"line":98,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4516ef82c60f43ceaac02a80e9d61a12","type":"text","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"2=Some effort against gravity, limb cannot get to or maintain","text_display":" 2=Some effort against gravity, limb cannot get to or maintain","confidence":1,"confidence_rate":1},{"cnt":[[1247,1739],[1437,1739],[1437,1768],[1247,1768]],"region":{"top_left_x":1246,"top_left_y":1739,"width":191,"height":30},"line":99,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fe3bad1d6cf240f7a9b2bcda8aa523a2","type":"text","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"(f cued) 90 degrees","text_display":" (f cued) 90 degrees","confidence":0.5924792289733887,"confidence_rate":0.9808000657293237},{"cnt":[[1206,1772],[1241,1772],[1241,1808],[1206,1808]],"region":{"top_left_x":1206,"top_left_y":1772,"width":36,"height":36},"line":100,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fc08592ec0d544dbb76a58de6d5b18cc","type":"form_field","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1241,1780],[1576,1780],[1576,1809],[1241,1809]],"region":{"top_left_x":1241,"top_left_y":1780,"width":335,"height":30},"line":101,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"795686935b6d4854b0ccf5aea70e9a0f","type":"text","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"3=No effort against gravity, limb falls","text_display":" 3=No effort against gravity, limb falls","confidence":0.9985356330871582,"confidence_rate":0.9999666950967584},{"cnt":[[1206,1813],[1240,1813],[1240,1847],[1206,1847]],"region":{"top_left_x":1206,"top_left_y":1813,"width":35,"height":35},"line":102,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"86f5d9da62534c9497eb1c44bf13c7fc","type":"form_field","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1240,1824],[1398,1824],[1398,1850],[1240,1850]],"region":{"top_left_x":1240,"top_left_y":1824,"width":159,"height":26},"line":103,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"af827baf66c743e284dfb930600492d1","type":"text","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"4=No movement","text_display":" 4=No movement","confidence":0.8862807750701904,"confidence_rate":0.9933156913392281},{"cnt":[[1206,1857],[1240,1857],[1240,1894],[1206,1894]],"region":{"top_left_x":1206,"top_left_y":1856,"width":35,"height":38},"line":104,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ea196089f9594144b3e3904519355d43","type":"form_field","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1240,1868],[1458,1868],[1458,1896],[1240,1896]],"region":{"top_left_x":1240,"top_left_y":1867,"width":219,"height":30},"line":105,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2edbbad3618347b9a99ee8f11e7eb31c","type":"text","conversion_output":false,"parent_id":"733a6a4aa5a9435699c76a2df82605c9","text":"Amputation, joint fusion","text_display":" Amputation, joint fusion","confidence":1,"confidence_rate":1},{"cnt":[[478,1963],[508,1963],[508,1990],[478,1990]],"region":{"top_left_x":477,"top_left_y":1963,"width":31,"height":28},"line":106,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"901ac15ff34648f38b8f2f2d450496b4","type":"simple_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"11","text_display":"11","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[699,1963],[1194,1963],[1194,1992],[699,1992]],"region":{"top_left_x":698,"top_left_y":1963,"width":496,"height":29},"line":107,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cf6e5011f89e41c2b3a9a2011ac486d5","type":"simple_cell","conversion_output":false,"parent_id":"b95237158c814207a9024bccc6986028","text":"Explain if amputation or joint fusion (Motor Arm Right):","text_display":"Explain if amputation or joint fusion (Motor Arm Right):","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[451,2393],[853,2393],[853,2428],[451,2428]],"region":{"top_left_x":451,"top_left_y":2393,"width":402,"height":35},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a17ca3c8c0f4803ac2865926f85edb7","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9931757408194244,"confidence_rate":0.9997717710175691},{"cnt":[[451,2428],[849,2428],[849,2460],[451,2460]],"region":{"top_left_x":451,"top_left_y":2427,"width":398,"height":33},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0881cee0ba294a6cabeb082e28479ab5","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 1","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1745,2428],[1788,2428],[1788,2471],[1745,2471]],"region":{"top_left_x":1744,"top_left_y":2427,"width":44,"height":44},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab539eec6ce54de3bab8934e43292cbc","type":"page_info","conversion_output":false,"text":"72","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f2212935be2413ab0141728241bae31","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936663979931382,"confidence_rate":0.9999022548641643},{"cnt":[[374,2608],[692,2608],[692,2640],[374,2640]],"region":{"top_left_x":373,"top_left_y":2608,"width":319,"height":33},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5be47fedfa7247009a3311f6f03aae59","type":"page_info","conversion_output":false,"text":"409/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-074","page":74,"lines":[{"cnt":[[922,363],[1311,363],[1311,419],[922,419]],"region":{"top_left_x":921,"top_left_y":363,"width":390,"height":56},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec286a09e6454752a27ef31cc2cac37a","type":"section_header","conversion_output":false,"children_ids":["c08d9f573aa64e5a88a026b841bcd8ea"],"text":"","text_display":""},{"cnt":[[924,367],[1308,367],[1308,415],[924,415]],"region":{"top_left_x":923,"top_left_y":367,"width":386,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c08d9f573aa64e5a88a026b841bcd8ea","type":"text","conversion_output":true,"parent_id":"ec286a09e6454752a27ef31cc2cac37a","text":"Appendix 7 (cont.)","text_display":"\n\n\\section*{Appendix 7 (cont.)}","confidence":1,"confidence_rate":1},{"cnt":[[606,404],[1631,404],[1631,466],[606,466]],"region":{"top_left_x":605,"top_left_y":403,"width":1026,"height":64},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1bf00e4d485549018feafd837e728d5c","type":"section_header","conversion_output":false,"children_ids":["492d7d747f8f4f9dad52ed7e7189694c"],"text":"","text_display":""},{"cnt":[[610,408],[1626,408],[1626,462],[610,462]],"region":{"top_left_x":610,"top_left_y":408,"width":1017,"height":54},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"492d7d747f8f4f9dad52ed7e7189694c","type":"text","conversion_output":true,"parent_id":"1bf00e4d485549018feafd837e728d5c","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":"\n\n\\section*{National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.970717191696167,"confidence_rate":0.9994597803747672},{"cnt":[[453,509],[1811,509],[1811,2022],[453,2022]],"region":{"top_left_x":453,"top_left_y":509,"width":1359,"height":1513},"line":5,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e0248ea2532e44bab7a4e9adad6769b1","type":"table","conversion_output":true,"children_ids":["b5b72977a1b644bd8293753c106ee153","6f76075263294e94a0f625b8518200a7","0833b2c7897c41528956b5120f6efa7e","b1abb18309af4cf696bb13e18655e8a9","4f4b5f3d0d9b42a6b5985702aacd4aae","9d1d441b201b424eb13b3e23e9278ba1","46512ea9984a4741845cec576e3c8ad5","a79739c145974e88986de6b924b9df9b","71edeec4557d44f5bb53659c270bd417","513dd2592d054c6589348b04dfe63c88","fe80586f4ca046fba6f5e8eb06a52dc7","18d67d6395e74f3982cc4b9066ab5ee4","767839b67ed8442dac1340c5d4e723c4","d294201c22c541a198b0d9ee84240790","3a49146c578f4ad6bd63854aef6c3c0f","40e84d644b0c4b5195b882f7d8d1376f","99addaac82b14ed7afa401f06cfd7501","d024ddd12a464d9d8f68113ac2478b6d","9c9405c019f54865acd9969283b1654b","15c2e856b26e41748ca5ca3ddf111961","5a4153332faa43f7a447d7a7be3df761","d1ed899555494fad91322760b4959d8f","9ebe6acea1c04ef3a38daaa4941334b6","adfa3cee014e4ace92491832bdb01433"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline 12 & \\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dont Is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputaton or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 13 & Explain if amputation/ joint fusion (Motor Leg Left): & \\\\\n\\hline 14 & \\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Drit? is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or jolnt fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ 1=Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg fails to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 15 & Explain if amputation/ joint fusion (Motor Leg Right): & \\\\\n\\hline 16 & \\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes open. In case of visual defect, insure testing is done in intact visual fleld. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxla is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation of joint fusion, the examiner should record the score as untestable (UN), and diearly write the explanation for this cholce. In case of bilndness, test by having the pattent touch nose from extended arm posttion. Coma score \\({ }^{\\circ} 0^{\\circ}\\).\n\\end{tabular} & ◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion \\\\\n\\hline 17 & Explain if amputation or joint fusion (Limb Ataxia): & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 12 & \\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dont Is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputaton or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 13 & Explain if amputation/ joint fusion (Motor Leg Left): & \\\\\n\\hline 14 & \\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Drit? is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or jolnt fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ 1=Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg fails to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 15 & Explain if amputation/ joint fusion (Motor Leg Right): & \\\\\n\\hline 16 & \\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes open. In case of visual defect, insure testing is done in intact visual fleld. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxla is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation of joint fusion, the examiner should record the score as untestable (UN), and diearly write the explanation for this cholce. In case of bilndness, test by having the pattent touch nose from extended arm posttion. Coma score \\({ }^{\\circ} 0^{\\circ}\\).\n\\end{tabular} & ◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion \\\\\n\\hline 17 & Explain if amputation or joint fusion (Limb Ataxia): & \\\\\n\\hline\n\\end{tabular}","confidence":0.13338706359873126,"confidence_rate":0.9979731007566295},{"cnt":[[478,509],[512,509],[512,2022],[478,2022]],"region":{"top_left_x":477,"top_left_y":509,"width":35,"height":1513},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b5b72977a1b644bd8293753c106ee153","type":"table_column","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"","text_display":""},{"cnt":[[532,509],[1094,509],[1094,2022],[532,2022]],"region":{"top_left_x":532,"top_left_y":509,"width":563,"height":1513},"line":7,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6f76075263294e94a0f625b8518200a7","type":"table_column","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"","text_display":""},{"cnt":[[1101,509],[1789,509],[1789,2022],[1101,2022]],"region":{"top_left_x":1100,"top_left_y":509,"width":689,"height":1513},"line":8,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0833b2c7897c41528956b5120f6efa7e","type":"table_column","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"","text_display":""},{"cnt":[[454,577],[1810,577],[1810,862],[454,862]],"region":{"top_left_x":454,"top_left_y":577,"width":1357,"height":286},"line":9,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b1abb18309af4cf696bb13e18655e8a9","type":"table_row","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"","text_display":""},{"cnt":[[453,943],[1810,943],[1810,976],[453,976]],"region":{"top_left_x":453,"top_left_y":942,"width":1358,"height":34},"line":10,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4f4b5f3d0d9b42a6b5985702aacd4aae","type":"table_row","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"","text_display":""},{"cnt":[[453,1061],[1810,1060],[1811,1351],[453,1352]],"region":{"top_left_x":452,"top_left_y":1059,"width":1359,"height":294},"line":11,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9d1d441b201b424eb13b3e23e9278ba1","type":"table_row","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"","text_display":""},{"cnt":[[453,1443],[1810,1443],[1810,1478],[453,1478]],"region":{"top_left_x":453,"top_left_y":1443,"width":1358,"height":35},"line":12,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"46512ea9984a4741845cec576e3c8ad5","type":"table_row","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"","text_display":""},{"cnt":[[453,1579],[1810,1579],[1810,1842],[453,1842]],"region":{"top_left_x":453,"top_left_y":1578,"width":1358,"height":264},"line":13,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a79739c145974e88986de6b924b9df9b","type":"table_row","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"","text_display":""},{"cnt":[[453,1939],[1810,1939],[1810,1973],[453,1973]],"region":{"top_left_x":453,"top_left_y":1938,"width":1358,"height":35},"line":14,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"71edeec4557d44f5bb53659c270bd417","type":"table_row","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"","text_display":""},{"cnt":[[475,705],[510,705],[510,727],[475,727]],"region":{"top_left_x":474,"top_left_y":705,"width":37,"height":23},"line":15,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"513dd2592d054c6589348b04dfe63c88","type":"simple_cell","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"12","text_display":"12","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[533,599],[1093,598],[1093,834],[534,836]],"region":{"top_left_x":532,"top_left_y":597,"width":562,"height":239},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fe80586f4ca046fba6f5e8eb06a52dc7","type":"complex_cell","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","children_ids":["17ee4817b0514cfba58ea9c249d32dbc","58a5adc6d6d742d197caa153f68b5b67","42ffbbfe7e8b4bad952cbf0ac232c4cb","87786a22ebe84e7b97a4f87a4788d5e5","d7b04c8b928e49d38ea6a16e0f134dd5","2b028f8faf0e4de1b13f2d9ec3ab7844","1b27413463b546ada7848b1451163020","5299de40216c48bca4b17590e6ef3201","9cab836e03eb401fb172470906930189","2a2ef71cb0774024b05ba44f9163593b"],"text":"\\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dont Is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputaton or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dont Is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputaton or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.15736270817844003,"confidence_rate":0.9936673348168177},{"cnt":[[723,602],[907,602],[907,628],[723,628]],"region":{"top_left_x":723,"top_left_y":601,"width":185,"height":27},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"17ee4817b0514cfba58ea9c249d32dbc","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"(6a) Motor Leg Left","text_display":"(6a) Motor Leg Left","confidence":1,"confidence_rate":1},{"cnt":[[536,647],[1089,647],[1089,670],[536,670]],"region":{"top_left_x":536,"top_left_y":646,"width":553,"height":24},"line":18,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"58a5adc6d6d742d197caa153f68b5b67","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"The imb is placed in the appropriate position: extend the arms (paims","text_display":"\nThe imb is placed in the appropriate position: extend the arms (paims","confidence":0.8783134114688139,"confidence_rate":0.9982481337666242},{"cnt":[[544,667],[1083,667],[1083,690],[544,690]],"region":{"top_left_x":544,"top_left_y":667,"width":540,"height":24},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"42ffbbfe7e8b4bad952cbf0ac232c4cb","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30","text_display":" down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30","confidence":0.45089218362366457,"confidence_rate":0.9900928148645918},{"cnt":[[540,689],[1087,689],[1087,710],[540,710]],"region":{"top_left_x":540,"top_left_y":689,"width":548,"height":21},"line":20,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"87786a22ebe84e7b97a4f87a4788d5e5","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"degrees (always tested suplne). Dont Is scored if the arm fals before","text_display":" degrees (always tested suplne). Dont Is scored if the arm fals before","confidence":0.15736270817844003,"confidence_rate":0.9753204310005804},{"cnt":[[565,708],[1066,708],[1066,731],[565,731]],"region":{"top_left_x":564,"top_left_y":708,"width":502,"height":24},"line":21,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d7b04c8b928e49d38ea6a16e0f134dd5","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"10 seconds or the leg before 5 seconds. The aphasic pattent is","text_display":" 10 seconds or the leg before 5 seconds. The aphasic pattent is","confidence":0.9366436004638672,"confidence_rate":0.9990518638021795},{"cnt":[[565,730],[1063,730],[1063,753],[565,753]],"region":{"top_left_x":564,"top_left_y":729,"width":499,"height":25},"line":22,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2b028f8faf0e4de1b13f2d9ec3ab7844","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"encouraged using urgency in the volce and pantomime but not","text_display":" encouraged using urgency in the volce and pantomime but not","confidence":0.7699961148310877,"confidence_rate":0.9959244245140498},{"cnt":[[548,749],[1076,749],[1076,772],[548,772]],"region":{"top_left_x":548,"top_left_y":749,"width":529,"height":24},"line":23,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1b27413463b546ada7848b1451163020","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"noxious stimulation. Each imb is tested in turn, beginning with the","text_display":" noxious stimulation. Each imb is tested in turn, beginning with the","confidence":0.8094983129684382,"confidence_rate":0.9970690177689878},{"cnt":[[551,771],[1076,771],[1076,791],[551,791]],"region":{"top_left_x":551,"top_left_y":770,"width":526,"height":22},"line":24,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5299de40216c48bca4b17590e6ef3201","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"non-paretic arm. Only in cases of amputaton or joint fusion at the","text_display":" non-paretic arm. Only in cases of amputaton or joint fusion at the","confidence":0.862253658038242,"confidence_rate":0.9979147716967034},{"cnt":[[535,790],[1093,790],[1093,812],[535,812]],"region":{"top_left_x":534,"top_left_y":790,"width":559,"height":22},"line":25,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9cab836e03eb401fb172470906930189","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"shoulder or hip can the examiner indicate no score and an explanation","text_display":" shoulder or hip can the examiner indicate no score and an explanation","confidence":0.882897853734903,"confidence_rate":0.9983183646439534},{"cnt":[[669,809],[959,809],[959,832],[669,832]],"region":{"top_left_x":668,"top_left_y":809,"width":292,"height":24},"line":26,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2a2ef71cb0774024b05ba44f9163593b","type":"text","conversion_output":false,"parent_id":"fe80586f4ca046fba6f5e8eb06a52dc7","text":"must be provided. Coma score \"4\".","text_display":" must be provided. Coma score \"4\".","confidence":0.5635822470668717,"confidence_rate":0.9850227132772426},{"cnt":[[1102,579],[1780,579],[1780,860],[1102,860]],"region":{"top_left_x":1102,"top_left_y":578,"width":679,"height":282},"line":27,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"18d67d6395e74f3982cc4b9066ab5ee4","type":"complex_cell","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","children_ids":["7908c60fe9394e5284a81c853c818e5b","a70fa3dfb68a418ab4f6c02255cb122e","358245ec6c3d466a97a13a5cca767bac","1702ac94d3554d48a1136d86ff55d926","d9ba65c045454a80b3f8c67a48152024","42f6bb11321d43659122cbbaddb0dc08","ea56110b185d4d1a86e49392f2ec2f18","32762462d7184bd59ff4763a742a01a4","1941614426774ead91ca89accb79dc5d","1374f2c439084030910a9f64998df774","7a29cb0bd2b548f7852ffaf88ee767cf","de0099e884e140b48f84981dc0b3bf04","f121d9be85414bcb8cf92bf161b4cb8a"],"text":"◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion","text_display":"◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.6161566959926859,"confidence_rate":0.99851853374385},{"cnt":[[1105,580],[1138,580],[1138,614],[1105,614]],"region":{"top_left_x":1105,"top_left_y":579,"width":33,"height":36},"line":28,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7908c60fe9394e5284a81c853c818e5b","type":"form_field","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1141,588],[1668,588],[1668,617],[1141,617]],"region":{"top_left_x":1140,"top_left_y":588,"width":529,"height":29},"line":29,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a70fa3dfb68a418ab4f6c02255cb122e","type":"text","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"0=No drift, leg holds 30 degrees position for full 5 seconds","text_display":" 0=No drift, leg holds 30 degrees position for full 5 seconds","confidence":0.9814708151388913,"confidence_rate":0.9997366121480871},{"cnt":[[1105,624],[1138,624],[1138,658],[1105,658]],"region":{"top_left_x":1105,"top_left_y":623,"width":33,"height":35},"line":30,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"358245ec6c3d466a97a13a5cca767bac","type":"form_field","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1142,635],[1775,635],[1775,660],[1142,660]],"region":{"top_left_x":1141,"top_left_y":634,"width":634,"height":27},"line":31,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1702ac94d3554d48a1136d86ff55d926","type":"text","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"\\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed","text_display":" \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed","confidence":0.9731700358679518,"confidence_rate":0.9996642976219948},{"cnt":[[1105,666],[1138,666],[1138,699],[1105,699]],"region":{"top_left_x":1105,"top_left_y":665,"width":33,"height":34},"line":32,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d9ba65c045454a80b3f8c67a48152024","type":"form_field","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,677],[1754,677],[1754,701],[1138,701]],"region":{"top_left_x":1137,"top_left_y":676,"width":618,"height":26},"line":33,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"42f6bb11321d43659122cbbaddb0dc08","type":"text","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"2=Some effort against gravity, leg falls to bed by 5 seconds, but has","text_display":" 2=Some effort against gravity, leg falls to bed by 5 seconds, but has","confidence":0.6161566959926859,"confidence_rate":0.9937307218352884},{"cnt":[[1149,703],[1393,703],[1393,729],[1149,729]],"region":{"top_left_x":1148,"top_left_y":702,"width":245,"height":27},"line":34,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ea56110b185d4d1a86e49392f2ec2f18","type":"text","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"some effort against gravity","text_display":" some effort against gravity","confidence":1,"confidence_rate":1},{"cnt":[[1105,735],[1138,735],[1138,768],[1105,768]],"region":{"top_left_x":1105,"top_left_y":735,"width":33,"height":34},"line":35,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"32762462d7184bd59ff4763a742a01a4","type":"form_field","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,745],[1638,745],[1638,772],[1138,772]],"region":{"top_left_x":1137,"top_left_y":745,"width":502,"height":28},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1941614426774ead91ca89accb79dc5d","type":"text","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"3=No effort against gravity; leg falls to bed immediately","text_display":" 3=No effort against gravity; leg falls to bed immediately","confidence":0.9728991830016298,"confidence_rate":0.9995569559672494},{"cnt":[[1105,776],[1138,776],[1138,809],[1105,809]],"region":{"top_left_x":1105,"top_left_y":776,"width":33,"height":34},"line":37,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1374f2c439084030910a9f64998df774","type":"form_field","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,787],[1296,787],[1296,810],[1138,810]],"region":{"top_left_x":1137,"top_left_y":787,"width":160,"height":24},"line":38,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7a29cb0bd2b548f7852ffaf88ee767cf","type":"text","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"4=No movement","text_display":" 4=No movement","confidence":0.9466374459575491,"confidence_rate":0.9969580193434415},{"cnt":[[1105,820],[1138,820],[1138,855],[1105,855]],"region":{"top_left_x":1105,"top_left_y":820,"width":33,"height":36},"line":39,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"de0099e884e140b48f84981dc0b3bf04","type":"form_field","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,831],[1355,831],[1355,857],[1138,857]],"region":{"top_left_x":1137,"top_left_y":830,"width":218,"height":27},"line":40,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f121d9be85414bcb8cf92bf161b4cb8a","type":"text","conversion_output":false,"parent_id":"18d67d6395e74f3982cc4b9066ab5ee4","text":"Amputation, joint fusion","text_display":" Amputation, joint fusion","confidence":1,"confidence_rate":1},{"cnt":[[475,947],[510,947],[510,970],[475,970]],"region":{"top_left_x":474,"top_left_y":946,"width":37,"height":25},"line":41,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"767839b67ed8442dac1340c5d4e723c4","type":"simple_cell","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"13","text_display":"13","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[636,946],[1093,946],[1093,973],[636,973]],"region":{"top_left_x":635,"top_left_y":945,"width":458,"height":28},"line":42,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d294201c22c541a198b0d9ee84240790","type":"simple_cell","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"Explain if amputation/ joint fusion (Motor Leg Left):","text_display":"Explain if amputation/ joint fusion (Motor Leg Left):","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9960978019516915,"confidence_rate":0.9999325913843436},{"cnt":[[486,1190],[510,1190],[510,1213],[486,1213]],"region":{"top_left_x":485,"top_left_y":1189,"width":26,"height":24},"line":43,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3a49146c578f4ad6bd63854aef6c3c0f","type":"simple_cell","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","text":"14","text_display":"14","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[532,1081],[1094,1081],[1094,1322],[532,1322]],"region":{"top_left_x":532,"top_left_y":1080,"width":563,"height":243},"line":44,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"40e84d644b0c4b5195b882f7d8d1376f","type":"complex_cell","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","children_ids":["9c5fc905909b46a6aacc883543693d92","04674d4c2fbe479e85d2119931929882","6d02be0ee0ce4a8c812b8e2033a7a993","8378ca4c326748239de88627f9760aeb","f8b0966ba3204f70a249222651ee29ac","62fdf0604fb04736959337b81300c9b2","6ee74de580ff46639d1acce8a5fd3f1f","0bddadd2c95c4b46b1d8dadb206ca81f","3a30b2e4477042aca2f874e021a70a3e","44e4a6cbd6ac4b0eada0602fc3a993bc"],"text":"\\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Drit? is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or jolnt fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Drit? is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or jolnt fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.13338706359873126,"confidence_rate":0.9938163800490906},{"cnt":[[715,1087],[913,1087],[913,1113],[715,1113]],"region":{"top_left_x":714,"top_left_y":1087,"width":199,"height":27},"line":45,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9c5fc905909b46a6aacc883543693d92","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"(6b) Motor Leg Right","text_display":"(6b) Motor Leg Right","confidence":1,"confidence_rate":1},{"cnt":[[535,1134],[1087,1134],[1087,1157],[535,1157]],"region":{"top_left_x":534,"top_left_y":1133,"width":554,"height":24},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"04674d4c2fbe479e85d2119931929882","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"The imb is placed in the appropriate position: extend the arms (paims","text_display":"\nThe imb is placed in the appropriate position: extend the arms (paims","confidence":0.8956503462977707,"confidence_rate":0.9985118491978437},{"cnt":[[535,1156],[1074,1156],[1074,1177],[535,1177]],"region":{"top_left_x":534,"top_left_y":1155,"width":540,"height":23},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6d02be0ee0ce4a8c812b8e2033a7a993","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30","text_display":" down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30","confidence":0.5500026696965203,"confidence_rate":0.9925549508728762},{"cnt":[[535,1175],[1079,1175],[1079,1198],[535,1198]],"region":{"top_left_x":534,"top_left_y":1174,"width":546,"height":24},"line":48,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8378ca4c326748239de88627f9760aeb","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"degrees (always tested suplne). Drit? is scored if the arm fals before","text_display":" degrees (always tested suplne). Drit? is scored if the arm fals before","confidence":0.13338706359873126,"confidence_rate":0.9734975200186066},{"cnt":[[535,1194],[1038,1194],[1038,1217],[535,1217]],"region":{"top_left_x":534,"top_left_y":1193,"width":505,"height":25},"line":49,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f8b0966ba3204f70a249222651ee29ac","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"10 seconds or the leg before 5 seconds. The aphasic patient is","text_display":" 10 seconds or the leg before 5 seconds. The aphasic patient is","confidence":0.982460707898781,"confidence_rate":0.9997435846481683},{"cnt":[[535,1216],[1033,1216],[1033,1239],[535,1239]],"region":{"top_left_x":534,"top_left_y":1215,"width":499,"height":24},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"62fdf0604fb04736959337b81300c9b2","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"encouraged using urgency in the volce and pantomime but not","text_display":" encouraged using urgency in the volce and pantomime but not","confidence":0.9912254726530136,"confidence_rate":0.9998623024468826},{"cnt":[[535,1237],[1063,1237],[1063,1259],[535,1259]],"region":{"top_left_x":534,"top_left_y":1237,"width":529,"height":23},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6ee74de580ff46639d1acce8a5fd3f1f","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"noxious stimulation. Each imb is tested in turn, beginning with the","text_display":" noxious stimulation. Each imb is tested in turn, beginning with the","confidence":0.5183200337120237,"confidence_rate":0.990914271378241},{"cnt":[[535,1257],[1057,1257],[1057,1280],[535,1280]],"region":{"top_left_x":534,"top_left_y":1256,"width":524,"height":24},"line":52,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0bddadd2c95c4b46b1d8dadb206ca81f","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"non-paretic arm. Only in cases of amputation or jolnt fusion at the","text_display":" non-paretic arm. Only in cases of amputation or jolnt fusion at the","confidence":0.4851693827221211,"confidence_rate":0.9900050459213425},{"cnt":[[535,1276],[1093,1276],[1093,1299],[535,1299]],"region":{"top_left_x":534,"top_left_y":1275,"width":559,"height":24},"line":53,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3a30b2e4477042aca2f874e021a70a3e","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"shoulder or hip can the examiner indicate no score and an explanation","text_display":" shoulder or hip can the examiner indicate no score and an explanation","confidence":0.9117907653562725,"confidence_rate":0.9987528764249448},{"cnt":[[535,1297],[823,1297],[823,1321],[535,1321]],"region":{"top_left_x":534,"top_left_y":1297,"width":289,"height":24},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"44e4a6cbd6ac4b0eada0602fc3a993bc","type":"text","conversion_output":false,"parent_id":"40e84d644b0c4b5195b882f7d8d1376f","text":"must be provided. Coma score \"4\".","text_display":" must be provided. Coma score \"4\".","confidence":0.8147486787715618,"confidence_rate":0.9946230451425526},{"cnt":[[1102,1066],[1780,1066],[1780,1347],[1102,1347]],"region":{"top_left_x":1102,"top_left_y":1065,"width":679,"height":282},"line":55,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"99addaac82b14ed7afa401f06cfd7501","type":"complex_cell","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","children_ids":["1c5afd1298cb4e69918f87e286ca40d2","02b6bfa7e2084b948d018f3271a849ee","f1caeedf58c843fda2b363a7eedd633c","af10addd93b14fdeb18b99f55ed22ce1","52044bc3ffad46189e6438d63c1f7201","8ac5bade62934bdb9db1bb43b2e0f0da","af46e88c8c7a4388a08a058a02a2eace","4ac7aa3025e84e25a37847f990273131","ac12334bb82e4c53bfb93a01ffabdb20","6798223a3e1f4a5f9daf75ac80ac457d","3e60661ab3084cc0bee06100262689ff","b04413f9dbde48eabb3f749af04478d4","427a135385394713b85b4309340fbffe"],"text":"◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ 1=Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg fails to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion","text_display":"◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ 1=Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg fails to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.4444459727742469,"confidence_rate":0.995028024735283},{"cnt":[[1105,1066],[1138,1066],[1138,1101],[1105,1101]],"region":{"top_left_x":1105,"top_left_y":1065,"width":33,"height":37},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1c5afd1298cb4e69918f87e286ca40d2","type":"form_field","conversion_output":false,"parent_id":"99addaac82b14ed7afa401f06cfd7501","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1138,1076],[1668,1076],[1668,1104],[1138,1104]],"region":{"top_left_x":1137,"top_left_y":1076,"width":532,"height":28},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"02b6bfa7e2084b948d018f3271a849ee","type":"text","conversion_output":false,"parent_id":"99addaac82b14ed7afa401f06cfd7501","text":"\\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds","text_display":" \\(0=\\) No drift, leg holds 30 degrees 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bed","confidence":0.5539286136627197,"confidence_rate":0.9927336953781414},{"cnt":[[1105,1153],[1138,1153],[1138,1186],[1105,1186]],"region":{"top_left_x":1105,"top_left_y":1152,"width":33,"height":34},"line":60,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"52044bc3ffad46189e6438d63c1f7201","type":"form_field","conversion_output":false,"parent_id":"99addaac82b14ed7afa401f06cfd7501","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,1161],[1754,1161],[1754,1190],[1138,1190]],"region":{"top_left_x":1137,"top_left_y":1161,"width":618,"height":29},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8ac5bade62934bdb9db1bb43b2e0f0da","type":"text","conversion_output":false,"parent_id":"99addaac82b14ed7afa401f06cfd7501","text":"2=Some effort against gravity; leg fails to bed by 5 seconds, but has","text_display":" 2=Some effort against gravity; leg fails to bed by 5 seconds, but 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Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes open. In case of visual defect, insure testing is done in intact visual fleld. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxla is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation of joint fusion, the examiner should record the score as untestable (UN), and diearly write the explanation for this cholce. In case of bilndness, test by having the pattent touch nose from extended arm posttion. Coma score \\({ }^{\\circ} 0^{\\circ}\\).\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes open. In case of visual defect, insure testing is done in intact visual fleld. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxla is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation of joint fusion, the examiner should record the score as untestable (UN), and diearly write the explanation for this cholce. In case of bilndness, test by having the pattent touch nose from extended arm posttion. Coma score \\({ }^{\\circ} 0^{\\circ}\\).\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.20925746973437884,"confidence_rate":0.9934253838437117},{"cnt":[[739,1584],[888,1584],[888,1610],[739,1610]],"region":{"top_left_x":739,"top_left_y":1583,"width":150,"height":27},"line":73,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a49f1fa5199e454ab5647fb5091488b0","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"(7) Limb Ataxia","text_display":"(7) Limb Ataxia","confidence":1,"confidence_rate":1},{"cnt":[[535,1630],[1090,1630],[1090,1654],[535,1654]],"region":{"top_left_x":534,"top_left_y":1630,"width":557,"height":24},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7339825df7194da7abf3fef388006e8a","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"This item is aimed at finding evidence of a unilateral cerebelar lesion.","text_display":"\nThis item is aimed at finding evidence of a unilateral cerebelar lesion.","confidence":0.9573344352676566,"confidence_rate":0.9994338942407396},{"cnt":[[535,1652],[1090,1652],[1090,1675],[535,1675]],"region":{"top_left_x":534,"top_left_y":1652,"width":557,"height":24},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"944e02b38ac748b8a5db62eb0cd2b975","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"Test with eyes open. In case of visual defect, insure testing is done in","text_display":" Test with eyes open. In case of visual defect, insure testing is done in","confidence":0.9527286585732805,"confidence_rate":0.9993712998018925},{"cnt":[[559,1674],[1068,1674],[1068,1694],[559,1694]],"region":{"top_left_x":559,"top_left_y":1674,"width":510,"height":21},"line":76,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1a50ad3b5dc1409cb276f8ed4e6be479","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"intact visual fleld. The finger-nose-finger and heel-shin tests are","text_display":" intact visual fleld. The finger-nose-finger and heel-shin tests are","confidence":0.20925746973437884,"confidence_rate":0.9785094257445208},{"cnt":[[548,1693],[1079,1693],[1079,1716],[548,1716]],"region":{"top_left_x":548,"top_left_y":1693,"width":532,"height":24},"line":77,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"401484d4003e4aada68b481a524411db","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"performed on both sides, and ataxla is scored only if present put of","text_display":" performed on both sides, and ataxla is scored only if present put of","confidence":0.4166432234690183,"confidence_rate":0.9880781420812534},{"cnt":[[548,1712],[1081,1712],[1081,1735],[548,1735]],"region":{"top_left_x":548,"top_left_y":1712,"width":533,"height":24},"line":78,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fd6ec73d80334b1396eeac6b0a3cfde4","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"proportion to weakness. Ataxla is absent in the patient who cannot","text_display":" proportion to weakness. Ataxla is absent in the patient who cannot","confidence":0.8332926791354112,"confidence_rate":0.9974346996404456},{"cnt":[[548,1733],[1079,1733],[1079,1754],[548,1754]],"region":{"top_left_x":548,"top_left_y":1732,"width":532,"height":23},"line":79,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"85d3839ac5eb43fd8ee40d34b4685c95","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"understand or is paralyzed. Only in the case of amputation of joint","text_display":" understand or is paralyzed. Only in the case of amputation of joint","confidence":0.6405454008215572,"confidence_rate":0.9938324965469828},{"cnt":[[538,1753],[1089,1753],[1089,1776],[538,1776]],"region":{"top_left_x":537,"top_left_y":1753,"width":552,"height":24},"line":80,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2bed6b52376d448c92bac687ae8d2de6","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"fusion, the examiner should record the score as untestable (UN), and","text_display":" fusion, the examiner should record the score as untestable (UN), and","confidence":0.9931697845458984,"confidence_rate":0.999906118816199},{"cnt":[[538,1775],[1090,1775],[1090,1798],[538,1798]],"region":{"top_left_x":537,"top_left_y":1774,"width":554,"height":25},"line":81,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8d9197df2998443183ad80755277e5cc","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"diearly write the explanation for this cholce. In case of bilndness, test","text_display":" diearly write the explanation for this cholce. In case of bilndness, test","confidence":0.6040815993136409,"confidence_rate":0.9935587065447375},{"cnt":[[570,1794],[1057,1794],[1057,1817],[570,1817]],"region":{"top_left_x":570,"top_left_y":1794,"width":488,"height":24},"line":82,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f6a7a0121c7b41a3b11fe7cb77557a5c","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"by having the pattent touch nose from extended arm posttion.","text_display":" by having the pattent touch nose from extended arm posttion.","confidence":0.43231842981867885,"confidence_rate":0.9871814381234059},{"cnt":[[748,1816],[880,1816],[880,1834],[748,1834]],"region":{"top_left_x":747,"top_left_y":1815,"width":133,"height":19},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f582ba6cda4e446b805fd8800e51cc44","type":"text","conversion_output":false,"parent_id":"5a4153332faa43f7a447d7a7be3df761","text":"Coma score \\({ }^{\\circ} 0^{\\circ}\\).","text_display":" Coma score \\({ }^{\\circ} 0^{\\circ}\\).","confidence":0.6987448972158696,"confidence_rate":0.9906109456219787},{"cnt":[[1102,1626],[1427,1626],[1427,1798],[1102,1798]],"region":{"top_left_x":1102,"top_left_y":1626,"width":326,"height":173},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d1ed899555494fad91322760b4959d8f","type":"complex_cell","conversion_output":false,"parent_id":"e0248ea2532e44bab7a4e9adad6769b1","children_ids":["7ff881449d64460a8b6e917f61ab90a0","2921153b0b1e400a8813f6d26e5e7f54","05345dc9f9ad4987998bb5d4d21e61cf","0d59e61b24d141be8053104c742d86de","65f6e0893e73456bababbd4e7050a910","ab57280827424892a949808554d0632f","688a2460210e4afebcd4fd9f16122a6d","0b6f203e43cf4d9ca67f98df35aee5d5"],"text":"◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion","text_display":"◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two 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(Limb Ataxia):","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[451,2391],[853,2391],[853,2430],[451,2430]],"region":{"top_left_x":451,"top_left_y":2391,"width":402,"height":39},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c24854396f2443f7865ee45b824a8fc5","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936616389313713,"confidence_rate":0.9997880713345346},{"cnt":[[451,2428],[849,2428],[849,2460],[451,2460]],"region":{"top_left_x":451,"top_left_y":2427,"width":398,"height":33},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be5944aa39e647c59285debf8849f5e4","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 1","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1745,2428],[1788,2428],[1788,2471],[1745,2471]],"region":{"top_left_x":1744,"top_left_y":2427,"width":44,"height":44},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"caa60dcc666045f6bb6f8a6d7586e223","type":"page_info","conversion_output":false,"text":"73","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4bfac4509674336b4bcb3e5c67bfdb2","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9931802598336503,"confidence_rate":0.999894727066751},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97b89218b2ea4778b93f0edc9a6c8ecb","type":"page_info","conversion_output":false,"text":"410/aCSR ML29093","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999767431038692}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-075","page":75,"lines":[{"cnt":[[604,361],[1631,361],[1631,466],[604,466]],"region":{"top_left_x":603,"top_left_y":360,"width":1028,"height":107},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8b0ebaad05c4cfba537a1ae281794c4","type":"section_header","conversion_output":false,"children_ids":["ba5d31f2a0964d8ca711221ab9a36b48","5df9fd619f1941b3855517afc23ade2a"],"text":"","text_display":""},{"cnt":[[924,365],[1308,365],[1308,415],[924,415]],"region":{"top_left_x":923,"top_left_y":365,"width":386,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba5d31f2a0964d8ca711221ab9a36b48","type":"text","conversion_output":true,"parent_id":"f8b0ebaad05c4cfba537a1ae281794c4","text":"Appendix 7 (cont.)","text_display":"\n\n\\section*{Appendix 7 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[610,408],[1626,408],[1626,462],[610,462]],"region":{"top_left_x":610,"top_left_y":408,"width":1017,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5df9fd619f1941b3855517afc23ade2a","type":"text","conversion_output":true,"parent_id":"f8b0ebaad05c4cfba537a1ae281794c4","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":" National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.970717191696167,"confidence_rate":0.9994597803747672},{"cnt":[[453,507],[1779,507],[1779,1985],[453,1985]],"region":{"top_left_x":453,"top_left_y":507,"width":1326,"height":1479},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0fd68b8bd140456db33552b464b8372e","type":"table","conversion_output":true,"children_ids":["09f3a297d3c9487f8c55cae75824d28c","7c32d997a2964e899823bd9becef2108","09fc1157fec04707931c974bc5d40582","03612409bcb0423ebe9dbfa7ac6b44e1","9a9e144c6a5940599f66490c7b122588","b60995d612d14c1a82462725ceb9ee5b","eabb224448d542b29f63b18fa2c9793e","5c04f581b01e44d3bc20eb4f070ded71","b175877749a74513b805d1e99cf487ae","692c0e5e4f6f4cd6b8ffb25b7ba14b54","c2ed08c91c2745b3806b39087918df58","a8202c4f020e4bfcaa06234693059d50","a77640dc9c014547b2398eb3ea0b5158","4411946ce89b491faffa4281c57db5b0","e6041d63c37642a5ad747a61061efac4","5bbba521ec08410287f2fea058612f66","649d37636be640eea4acf3969317f638","5ddb52f86d424dbfa63c0a14c1355e1d","f6778f6f0e60409aab85d3c587eef078","6eeb95c71da2498aac209ffb11920a74","8ee84e9b43e14290afb36a7d13f559e9","135d3b1de2fb4f8caf3b841bca867c86","8a62aa884790489f89eb9a15b53451ba","500c928f64df4503965bd5af26e4451e","0e98b7c4120b416f8504a1008d427823","899b9a56643d414ba2b5d4c0fb22c01f","0b99501c0181469da96f107b720fa82f","bed568dd14674cf39933c9612bdaf1b4","8b11dc72e8f4470397d38535aba75b2d","64fd1fcd9f994048bfe3bcefd9c3b619"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline 18 & \\begin{tabular}{l}\n(8) Sensory \\\\\nSensaton or grimace to pin prick when tested, or withdrawal from noxlous stmous in the obtunded or aphasic patient. Only sensory loss attributed to stroke is scored as abnormal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, \"severe or total,\" should only be given when a severe or total joss of sensation can be cleany demonstrated. Stuporous and aphasic patlents will therefore probably score 1 or 0 . The pattent with brain stem stroke who has bilateral loss of sensation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (tem 13-3) are arbitrartly given a 2 on this tem. Coma Score \"2\".\n\\end{tabular} & ◯ 0=Normal; no sensory loss\n◯ \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side; or there is a loss of superficial pain with pinprick but patient is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg \\\\\n\\hline 19 & \\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of Information about comprehension with be obtained during the preceding sections of the examination. The patent is asked to describe what is happening in the allached ploture, to name the items on the attached naming sheet, and to read from the attached ist of sentences. Comprehension is judged from responses here as well as to al of the commands in the preceding general neurological exam. If visual loss interferes with the tests, ask the patient to identify objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to write. The pattent in coma (question 13-3) will artoltrarly score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a score of 3 should be used only if the patient is mute and follows no one step commands. Coma Score \" 3 \".\n\\end{tabular} & ◯ 0=No aphasia, normal\n◯ 1=Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2=Severe aphasia; all communication is through fragmentary expression, great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension \\\\\n\\hline 20 & \\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be normal an adequate sample of speech must be obtained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the clarity of arioulation of spontaneous speech can be rated. Only if the patient is intubated or has other physical barrier to producing speech, may the them be not scored, and the examiner must clearly write an explanation. Do not teil the patlent why helshe is being tested. Coma Score \"2\"\n\\end{tabular} & ◯ 0=Normal\n◯ \\(1=\\) Mild to moderate; patient slurs at least some words and at worst. can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mutel anarthric\n◯ Intubated or other physical barrier. \\\\\n\\hline 21 & Explain if intubated or other physical barrier (Dysarthria): & \\\\\n\\hline 22 & \\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumbient information to Identity negiect may be obtained during the proor testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the culaneous stimulil are normal, the score is normal. If the patient has aphasla dur does appear to attend to both sldes, the score is normal. The presence of visual spattal neglect or anosagnosla may also be taken as evidence of abnormailty. Since the abnormality is scored only if present, the item is never untestable. Coma Score \" 2 \".\n\\end{tabular} & ◯ \\(0=\\) No abnormality\n◯ \\(1=\\) Visual, tactile, auditory, spatial, or personal inattention or extinction to bilateral simultaneous stimulation in one of the sensory modalities\n◯ 2=Profound hemi-inattention or hemi-inattention to more than one modality; does not recognize own hand or orients to only one side of space \\\\\n\\hline 23 & \\begin{tabular}{l}\nDid NIHSS increase by \\(\\geq 2\\) points AND NIHSS score is now >5? \\\\\nIf YES, consider treating patient with IV rtPA as standard of care and unblinding of treatment assignment if appropriate. Note that patient will continue to be followed in the PRISMS trial regardless of decision. 5\n\\end{tabular} & ◯ No\n◯ Yes \\\\\n\\hline 24 & \\begin{tabular}{l}\nName of assessor: \\\\\nThe assessor must be a study team member who has completed NHSS certification.\n\\end{tabular} & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 18 & \\begin{tabular}{l}\n(8) Sensory \\\\\nSensaton or grimace to pin prick when tested, or withdrawal from noxlous stmous in the obtunded or aphasic patient. Only sensory loss attributed to stroke is scored as abnormal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, \"severe or total,\" should only be given when a severe or total joss of sensation can be cleany demonstrated. Stuporous and aphasic patlents will therefore probably score 1 or 0 . The pattent with brain stem stroke who has bilateral loss of sensation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (tem 13-3) are arbitrartly given a 2 on this tem. Coma Score \"2\".\n\\end{tabular} & ◯ 0=Normal; no sensory loss\n◯ \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side; or there is a loss of superficial pain with pinprick but patient is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg \\\\\n\\hline 19 & \\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of Information about comprehension with be obtained during the preceding sections of the examination. The patent is asked to describe what is happening in the allached ploture, to name the items on the attached naming sheet, and to read from the attached ist of sentences. Comprehension is judged from responses here as well as to al of the commands in the preceding general neurological exam. If visual loss interferes with the tests, ask the patient to identify objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to write. The pattent in coma (question 13-3) will artoltrarly score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a score of 3 should be used only if the patient is mute and follows no one step commands. Coma Score \" 3 \".\n\\end{tabular} & ◯ 0=No aphasia, normal\n◯ 1=Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2=Severe aphasia; all communication is through fragmentary expression, great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension \\\\\n\\hline 20 & \\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be normal an adequate sample of speech must be obtained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the clarity of arioulation of spontaneous speech can be rated. Only if the patient is intubated or has other physical barrier to producing speech, may the them be not scored, and the examiner must clearly write an explanation. Do not teil the patlent why helshe is being tested. Coma Score \"2\"\n\\end{tabular} & ◯ 0=Normal\n◯ \\(1=\\) Mild to moderate; patient slurs at least some words and at worst. can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mutel anarthric\n◯ Intubated or other physical barrier. \\\\\n\\hline 21 & Explain if intubated or other physical barrier (Dysarthria): & \\\\\n\\hline 22 & \\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumbient information to Identity negiect may be obtained during the proor testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the culaneous stimulil are normal, the score is normal. If the patient has aphasla dur does appear to attend to both sldes, the score is normal. The presence of visual spattal neglect or anosagnosla may also be taken as evidence of abnormailty. Since the abnormality is scored only if present, the item is never untestable. Coma Score \" 2 \".\n\\end{tabular} & ◯ \\(0=\\) No abnormality\n◯ \\(1=\\) Visual, tactile, auditory, spatial, or personal inattention or extinction to bilateral simultaneous stimulation in one of the sensory modalities\n◯ 2=Profound hemi-inattention or hemi-inattention to more than one modality; does not recognize own hand or orients to only one side of space \\\\\n\\hline 23 & \\begin{tabular}{l}\nDid NIHSS increase by \\(\\geq 2\\) points AND NIHSS score is now >5? \\\\\nIf YES, consider treating patient with IV rtPA as standard of care and unblinding of treatment assignment if appropriate. Note that patient will continue to be followed in the PRISMS trial regardless of decision. 5\n\\end{tabular} & ◯ No\n◯ Yes \\\\\n\\hline 24 & \\begin{tabular}{l}\nName of assessor: \\\\\nThe assessor must be a study team member who has completed NHSS certification.\n\\end{tabular} & \\\\\n\\hline\n\\end{tabular}","confidence":0.08071168698350396,"confidence_rate":0.9967927818866357},{"cnt":[[475,507],[512,507],[512,1983],[475,1983]],"region":{"top_left_x":474,"top_left_y":507,"width":38,"height":1477},"line":5,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"09f3a297d3c9487f8c55cae75824d28c","type":"table_column","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[525,507],[1124,507],[1124,1983],[525,1983]],"region":{"top_left_x":525,"top_left_y":507,"width":600,"height":1477},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7c32d997a2964e899823bd9becef2108","type":"table_column","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[1124,507],[1771,507],[1771,1984],[1124,1984]],"region":{"top_left_x":1124,"top_left_y":507,"width":647,"height":1478},"line":7,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"09fc1157fec04707931c974bc5d40582","type":"table_column","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[453,529],[1779,529],[1779,785],[453,785]],"region":{"top_left_x":453,"top_left_y":528,"width":1326,"height":258},"line":8,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"03612409bcb0423ebe9dbfa7ac6b44e1","type":"table_row","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[453,796],[1779,796],[1779,1103],[453,1103]],"region":{"top_left_x":453,"top_left_y":796,"width":1326,"height":308},"line":9,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9a9e144c6a5940599f66490c7b122588","type":"table_row","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[453,1113],[1779,1113],[1779,1362],[453,1362]],"region":{"top_left_x":453,"top_left_y":1112,"width":1326,"height":251},"line":10,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b60995d612d14c1a82462725ceb9ee5b","type":"table_row","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[453,1383],[1779,1383],[1779,1425],[453,1425]],"region":{"top_left_x":453,"top_left_y":1382,"width":1326,"height":44},"line":11,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"eabb224448d542b29f63b18fa2c9793e","type":"table_row","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[453,1456],[1779,1456],[1779,1690],[453,1690]],"region":{"top_left_x":453,"top_left_y":1456,"width":1326,"height":234},"line":12,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5c04f581b01e44d3bc20eb4f070ded71","type":"table_row","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[453,1709],[1779,1709],[1779,1867],[453,1867]],"region":{"top_left_x":453,"top_left_y":1708,"width":1326,"height":160},"line":13,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b175877749a74513b805d1e99cf487ae","type":"table_row","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[453,1877],[1778,1877],[1778,1978],[453,1978]],"region":{"top_left_x":453,"top_left_y":1876,"width":1325,"height":102},"line":14,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"692c0e5e4f6f4cd6b8ffb25b7ba14b54","type":"table_row","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":""},{"cnt":[[475,639],[508,639],[508,669],[475,669]],"region":{"top_left_x":474,"top_left_y":639,"width":34,"height":31},"line":15,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c2ed08c91c2745b3806b39087918df58","type":"simple_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"18","text_display":"18","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[531,532],[1121,532],[1121,784],[531,784]],"region":{"top_left_x":530,"top_left_y":531,"width":592,"height":253},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a8202c4f020e4bfcaa06234693059d50","type":"complex_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","children_ids":["22638f06e6d249fb87e1b614836244fc","99c2a96606be48598076d70f46ae47be","b0a6aca5593b41978a4425f0b68b790c","6bbe85d8144b42d799d6aa6cbe22e2d9","2366ca0976d24e5aafc9f8c0f3dd6b1f","53022757eb8a445780b959c3a00038ca","1692a2084d6f4265aa4e7513429150ac","442307512a664064890f4611c696f082","32eb8d7144eb439ca2fb5e34c40b8ea5","d768e966873245ac845ecba4bec41e0d","50a6db7101354d499f2fcc0d95d229b6"],"text":"\\begin{tabular}{l}\n(8) Sensory \\\\\nSensaton or grimace to pin prick when tested, or withdrawal from noxlous stmous in the obtunded or aphasic patient. Only sensory loss attributed to stroke is scored as abnormal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, \"severe or total,\" should only be given when a severe or total joss of sensation can be cleany demonstrated. Stuporous and aphasic patlents will therefore probably score 1 or 0 . The pattent with brain stem stroke who has bilateral loss of sensation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (tem 13-3) are arbitrartly given a 2 on this tem. Coma Score \"2\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(8) Sensory \\\\\nSensaton or grimace to pin prick when tested, or withdrawal from noxlous stmous in the obtunded or aphasic patient. Only sensory loss attributed to stroke is scored as abnormal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, \"severe or total,\" should only be given when a severe or total joss of sensation can be cleany demonstrated. Stuporous and aphasic patlents will therefore probably score 1 or 0 . The pattent with brain stem stroke who has bilateral loss of sensation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (tem 13-3) are arbitrartly given a 2 on this tem. Coma Score \"2\".\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.31137023843100625,"confidence_rate":0.9944469972983992},{"cnt":[[769,537],[883,537],[883,563],[769,563]],"region":{"top_left_x":769,"top_left_y":537,"width":114,"height":26},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"22638f06e6d249fb87e1b614836244fc","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"(8) Sensory","text_display":"(8) Sensory","confidence":0.99853515625,"confidence_rate":0.9999083843418147},{"cnt":[[538,575],[1112,575],[1112,598],[538,598]],"region":{"top_left_x":537,"top_left_y":575,"width":575,"height":24},"line":18,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"99c2a96606be48598076d70f46ae47be","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"Sensaton or grimace to pin prick when tested, or withdrawal from noxlous","text_display":"\nSensaton or grimace to pin prick when tested, or withdrawal from noxlous","confidence":0.5675912413858859,"confidence_rate":0.99267173990899},{"cnt":[[538,597],[1115,597],[1115,619],[538,619]],"region":{"top_left_x":537,"top_left_y":597,"width":578,"height":22},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b0a6aca5593b41978a4425f0b68b790c","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"stmous in the obtunded or aphasic patient. Only sensory loss attributed to","text_display":" stmous in the obtunded or aphasic patient. Only sensory loss attributed to","confidence":0.4112291235857063,"confidence_rate":0.9888148627583634},{"cnt":[[542,616],[1111,616],[1111,639],[542,639]],"region":{"top_left_x":541,"top_left_y":616,"width":570,"height":24},"line":20,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6bbe85d8144b42d799d6aa6cbe22e2d9","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"stroke is scored as abnormal and the examiner should test as many body","text_display":" stroke is scored as abnormal and the examiner should test as many body","confidence":0.858691376771394,"confidence_rate":0.9979707855977746},{"cnt":[[543,638],[1109,638],[1109,661],[543,661]],"region":{"top_left_x":543,"top_left_y":637,"width":567,"height":25},"line":21,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2366ca0976d24e5aafc9f8c0f3dd6b1f","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"areas [arms (not hands), legs, trunk, face] as needed to accurately check","text_display":" areas [arms (not hands), legs, trunk, face] as needed to accurately check","confidence":0.9844143118243665,"confidence_rate":0.999798630252687},{"cnt":[[543,657],[1109,657],[1109,680],[543,680]],"region":{"top_left_x":543,"top_left_y":657,"width":567,"height":24},"line":22,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"53022757eb8a445780b959c3a00038ca","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"for hemisensory loss. A score of 2, \"severe or total,\" should only be given","text_display":" for hemisensory loss. A score of 2, \"severe or total,\" should only be given","confidence":0.9941530108969223,"confidence_rate":0.9999267008156625},{"cnt":[[558,676],[1094,676],[1094,699],[558,699]],"region":{"top_left_x":558,"top_left_y":676,"width":537,"height":24},"line":23,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1692a2084d6f4265aa4e7513429150ac","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"when a severe or total joss of sensation can be cleany demonstrated.","text_display":" when a severe or total joss of sensation can be cleany demonstrated.","confidence":0.5518056565404535,"confidence_rate":0.9918884289374154},{"cnt":[[546,695],[1106,695],[1106,718],[546,718]],"region":{"top_left_x":545,"top_left_y":695,"width":562,"height":24},"line":24,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"442307512a664064890f4611c696f082","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"Stuporous and aphasic patlents will therefore probably score 1 or 0 . The","text_display":" Stuporous and aphasic patlents will therefore probably score 1 or 0 . The","confidence":0.5634773813653737,"confidence_rate":0.9931943582071284},{"cnt":[[538,717],[1113,717],[1113,740],[538,740]],"region":{"top_left_x":537,"top_left_y":717,"width":577,"height":24},"line":25,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"32eb8d7144eb439ca2fb5e34c40b8ea5","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"pattent with brain stem stroke who has bilateral loss of sensation is scored","text_display":" pattent with brain stem stroke who has bilateral loss of sensation is scored","confidence":0.6755104093446324,"confidence_rate":0.9951686628115045},{"cnt":[[546,736],[1106,736],[1106,759],[546,759]],"region":{"top_left_x":545,"top_left_y":736,"width":562,"height":24},"line":26,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d768e966873245ac845ecba4bec41e0d","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"2. If the patent does not respond and is quadriplegic score 2. Patients in","text_display":" 2. If the patent does not respond and is quadriplegic score 2. Patients in","confidence":0.6487640157643066,"confidence_rate":0.9945379306245906},{"cnt":[[543,755],[1109,755],[1109,778],[543,778]],"region":{"top_left_x":543,"top_left_y":755,"width":567,"height":24},"line":27,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"50a6db7101354d499f2fcc0d95d229b6","type":"text","conversion_output":false,"parent_id":"a8202c4f020e4bfcaa06234693059d50","text":"coma (tem 13-3) are arbitrartly given a 2 on this tem. Coma Score \"2\".","text_display":" coma (tem 13-3) are arbitrartly given a 2 on this tem. Coma Score \"2\".","confidence":0.31137023843100625,"confidence_rate":0.9851527013777536},{"cnt":[[1130,559],[1769,559],[1769,762],[1130,762]],"region":{"top_left_x":1129,"top_left_y":558,"width":641,"height":205},"line":28,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a77640dc9c014547b2398eb3ea0b5158","type":"complex_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","children_ids":["ddb58ea96e514b3dbd4b4bfde0da5088","ccc54b97cfb545afaf99914fc5ec98a9","51a78445505d4caf894e144f92614bdd","bff5c644c2174dcb8c0dbd258eae1320","59b247ba7c4947208bc7312a327232c4","35f775b91e784c9e8a0c9982594de4a2","d265e58f25c24d35b0ac8c4b5aed3f02","1f0ec66459874a01bcfb99e511f256f7","0540bfa292cd42aea94d55c2cc1ef813"],"text":"◯ 0=Normal; no sensory loss\n◯ \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side; or there is a loss of superficial pain with pinprick but patient is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg","text_display":"◯ 0=Normal; no sensory loss\n◯ \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side; or there is a loss of superficial pain with pinprick but patient is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.748046875,"confidence_rate":0.9981658408138335},{"cnt":[[1132,562],[1166,562],[1166,598],[1132,598]],"region":{"top_left_x":1132,"top_left_y":561,"width":35,"height":38},"line":29,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ddb58ea96e514b3dbd4b4bfde0da5088","type":"form_field","conversion_output":false,"parent_id":"a77640dc9c014547b2398eb3ea0b5158","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1166,572],[1407,572],[1407,601],[1166,601]],"region":{"top_left_x":1166,"top_left_y":572,"width":241,"height":30},"line":30,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ccc54b97cfb545afaf99914fc5ec98a9","type":"text","conversion_output":false,"parent_id":"a77640dc9c014547b2398eb3ea0b5158","text":"0=Normal; no sensory loss","text_display":" 0=Normal; no sensory loss","confidence":0.8689626172333647,"confidence_rate":0.9953291036317771},{"cnt":[[1132,605],[1166,605],[1166,639],[1132,639]],"region":{"top_left_x":1132,"top_left_y":605,"width":35,"height":35},"line":31,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"51a78445505d4caf894e144f92614bdd","type":"form_field","conversion_output":false,"parent_id":"a77640dc9c014547b2398eb3ea0b5158","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1168,613],[1764,613],[1764,645],[1168,645]],"region":{"top_left_x":1167,"top_left_y":613,"width":597,"height":32},"line":32,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bff5c644c2174dcb8c0dbd258eae1320","type":"text","conversion_output":false,"parent_id":"a77640dc9c014547b2398eb3ea0b5158","text":"\\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp","text_display":" \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp","confidence":0.8812015224248171,"confidence_rate":0.9982924198958519},{"cnt":[[1184,643],[1761,643],[1761,669],[1184,669]],"region":{"top_left_x":1184,"top_left_y":643,"width":578,"height":27},"line":33,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"59b247ba7c4947208bc7312a327232c4","type":"text","conversion_output":false,"parent_id":"a77640dc9c014547b2398eb3ea0b5158","text":"or is dull on the affected side; or there is a loss of superficial pain","text_display":" or is dull on the affected side; or there is a loss of superficial pain","confidence":0.99560546875,"confidence_rate":0.9999420514740156},{"cnt":[[1184,668],[1693,668],[1693,694],[1184,694]],"region":{"top_left_x":1184,"top_left_y":667,"width":510,"height":27},"line":34,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"35f775b91e784c9e8a0c9982594de4a2","type":"text","conversion_output":false,"parent_id":"a77640dc9c014547b2398eb3ea0b5158","text":"with pinprick but patient is aware he/she is being touched","text_display":" with pinprick but patient is aware he/she is being touched","confidence":1,"confidence_rate":1},{"cnt":[[1132,695],[1166,695],[1166,729],[1132,729]],"region":{"top_left_x":1132,"top_left_y":695,"width":35,"height":35},"line":35,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d265e58f25c24d35b0ac8c4b5aed3f02","type":"form_field","conversion_output":false,"parent_id":"a77640dc9c014547b2398eb3ea0b5158","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1165,706],[1696,706],[1696,732],[1165,732]],"region":{"top_left_x":1165,"top_left_y":706,"width":531,"height":27},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1f0ec66459874a01bcfb99e511f256f7","type":"text","conversion_output":false,"parent_id":"a77640dc9c014547b2398eb3ea0b5158","text":"2=Severe to total sensory loss; patient is not aware of being","text_display":" 2=Severe to total sensory loss; patient is not aware of being","confidence":0.748046875,"confidence_rate":0.9956113306621722},{"cnt":[[1184,731],[1456,731],[1456,759],[1184,759]],"region":{"top_left_x":1184,"top_left_y":730,"width":272,"height":30},"line":37,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0540bfa292cd42aea94d55c2cc1ef813","type":"text","conversion_output":false,"parent_id":"a77640dc9c014547b2398eb3ea0b5158","text":"touched in the face, arm \\& leg","text_display":" touched in the face, arm \\& leg","confidence":0.994140625,"confidence_rate":0.9998321109952513},{"cnt":[[478,938],[510,938],[510,965],[478,965]],"region":{"top_left_x":477,"top_left_y":938,"width":34,"height":28},"line":38,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4411946ce89b491faffa4281c57db5b0","type":"simple_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"19","text_display":"19","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[529,799],[1123,799],[1123,1090],[529,1090]],"region":{"top_left_x":529,"top_left_y":798,"width":594,"height":292},"line":39,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e6041d63c37642a5ad747a61061efac4","type":"complex_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","children_ids":["9b008c027cc54bdba10261f844a9f13f","32e50debe4c74782887ef0d95a508b8c","f0386d0493f64c3f8189748ef288beb4","9c9f06cde4a147cbb22c1bda94ee5ddb","55cf4fbc817544ac95e1a5aeca00cd0e","c34b5c5a409542489d099c80294755ac","2fe79f3c108f43de8df8793452b96a1d","6ec469ea832643e99441ca15267ab70f","29555b0c80eb433589cabd7c638f69f9","08a69f5eeef44ec4a868c199344508ed","28cc3d6fc05945d6beef0491c3c904fc","29356a6569ed43a9931518b847708dba","db0d856db9fd4440bcbb92965e212fc9"],"text":"\\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of Information about comprehension with be obtained during the preceding sections of the examination. The patent is asked to describe what is happening in the allached ploture, to name the items on the attached naming sheet, and to read from the attached ist of sentences. Comprehension is judged from responses here as well as to al of the commands in the preceding general neurological exam. If visual loss interferes with the tests, ask the patient to identify objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to write. The pattent in coma (question 13-3) will artoltrarly score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a score of 3 should be used only if the patient is mute and follows no one step commands. Coma Score \" 3 \".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of Information about comprehension with be obtained during the preceding sections of the examination. The patent is asked to describe what is happening in the allached ploture, to name the items on the attached naming sheet, and to read from the attached ist of sentences. Comprehension is judged from responses here as well as to al of the commands in the preceding general neurological exam. If visual loss interferes with the tests, ask the patient to identify objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to write. The pattent in coma (question 13-3) will artoltrarly score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a score of 3 should be used only if the patient is mute and follows no one step commands. Coma Score \" 3 \".\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.08827533039999833,"confidence_rate":0.9942991696867414},{"cnt":[[734,802],[918,802],[918,829],[734,829]],"region":{"top_left_x":734,"top_left_y":801,"width":185,"height":28},"line":40,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9b008c027cc54bdba10261f844a9f13f","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"(9) Best Language","text_display":"(9) Best Language","confidence":0.9975600242614746,"confidence_rate":0.9998889626500882},{"cnt":[[532,840],[1120,840],[1120,864],[532,864]],"region":{"top_left_x":532,"top_left_y":839,"width":589,"height":26},"line":41,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"32e50debe4c74782887ef0d95a508b8c","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"A great deal of Information about comprehension with be obtained during the","text_display":"\nA great deal of Information about comprehension with be obtained during the","confidence":0.551655151683927,"confidence_rate":0.9925921723024759},{"cnt":[[548,862],[1101,862],[1101,885],[548,885]],"region":{"top_left_x":548,"top_left_y":861,"width":553,"height":24},"line":42,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f0386d0493f64c3f8189748ef288beb4","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"preceding sections of the examination. The patent is asked to describe","text_display":" preceding sections of the examination. The patent is asked to describe","confidence":0.6102812825900025,"confidence_rate":0.9934371593394604},{"cnt":[[565,882],[1087,882],[1087,904],[565,904]],"region":{"top_left_x":564,"top_left_y":882,"width":524,"height":22},"line":43,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9c9f06cde4a147cbb22c1bda94ee5ddb","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"what is happening in the allached ploture, to name the items on the","text_display":" what is happening in the allached ploture, to name the items on the","confidence":0.8299503663417637,"confidence_rate":0.9974146065185142},{"cnt":[[548,901],[1101,901],[1101,924],[548,924]],"region":{"top_left_x":548,"top_left_y":901,"width":553,"height":24},"line":44,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"55cf4fbc817544ac95e1a5aeca00cd0e","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"attached naming sheet, and to read from the attached ist of sentences.","text_display":" attached naming sheet, and to read from the attached ist of sentences.","confidence":0.8124661896223415,"confidence_rate":0.997234750652661},{"cnt":[[558,922],[1094,922],[1094,945],[558,945]],"region":{"top_left_x":558,"top_left_y":921,"width":537,"height":24},"line":45,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c34b5c5a409542489d099c80294755ac","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"Comprehension is judged from responses here as well as to al of the","text_display":" Comprehension is judged from responses here as well as to al of the","confidence":0.8198642730712891,"confidence_rate":0.9972452392103369},{"cnt":[[559,941],[1093,941],[1093,964],[559,964]],"region":{"top_left_x":559,"top_left_y":940,"width":534,"height":24},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2fe79f3c108f43de8df8793452b96a1d","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"commands in the preceding general neurological exam. If visual loss","text_display":" commands in the preceding general neurological exam. If visual loss","confidence":0.9515941143035889,"confidence_rate":0.9993111167554042},{"cnt":[[551,961],[1101,961],[1101,984],[551,984]],"region":{"top_left_x":551,"top_left_y":961,"width":550,"height":24},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6ec469ea832643e99441ca15267ab70f","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"interferes with the tests, ask the patient to identify objects placed in the","text_display":" interferes with the tests, ask the patient to identify objects placed in the","confidence":0.8873337101871905,"confidence_rate":0.998525358181599},{"cnt":[[538,982],[1112,982],[1112,1004],[538,1004]],"region":{"top_left_x":537,"top_left_y":981,"width":575,"height":23},"line":48,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"29555b0c80eb433589cabd7c638f69f9","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"hand, repeat, and produce speech. The intubated patent should be asked","text_display":" hand, repeat, and produce speech. The intubated patent should be asked","confidence":0.6575603485107422,"confidence_rate":0.9944260095296136},{"cnt":[[540,1001],[1112,1001],[1112,1024],[540,1024]],"region":{"top_left_x":540,"top_left_y":1000,"width":572,"height":25},"line":49,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"08a69f5eeef44ec4a868c199344508ed","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"to write. The pattent in coma (question 13-3) will artoltrarly score 3 on this","text_display":" to write. The pattent in coma (question 13-3) will artoltrarly score 3 on this","confidence":0.08827533039999833,"confidence_rate":0.9721702303528912},{"cnt":[[532,1020],[1120,1020],[1120,1043],[532,1043]],"region":{"top_left_x":532,"top_left_y":1019,"width":589,"height":25},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"28cc3d6fc05945d6beef0491c3c904fc","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"Item. The examiner must choose a score in the patient with stupor or limited","text_display":" Item. The examiner must choose a score in the patient with stupor or limited","confidence":0.48627662657427934,"confidence_rate":0.9911385379058887},{"cnt":[[540,1042],[1115,1042],[1115,1065],[540,1065]],"region":{"top_left_x":540,"top_left_y":1041,"width":575,"height":24},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"29356a6569ed43a9931518b847708dba","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"cooperation but a score of 3 should be used only if the patient is mute and","text_display":" cooperation but a score of 3 should be used only if the patient is mute and","confidence":0.918320078090022,"confidence_rate":0.9989739089581972},{"cnt":[[630,1061],[1023,1061],[1023,1087],[630,1087]],"region":{"top_left_x":630,"top_left_y":1060,"width":394,"height":27},"line":52,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"db0d856db9fd4440bcbb92965e212fc9","type":"text","conversion_output":false,"parent_id":"e6041d63c37642a5ad747a61061efac4","text":"follows no one step commands. Coma Score \" 3 \".","text_display":" follows no one step commands. Coma Score \" 3 \".","confidence":0.7122651835342546,"confidence_rate":0.9938498087268307},{"cnt":[[1129,805],[1769,803],[1770,1100],[1130,1102]],"region":{"top_left_x":1128,"top_left_y":803,"width":642,"height":299},"line":53,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5bbba521ec08410287f2fea058612f66","type":"complex_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","children_ids":["1ec81fe7f8dd46878743203d616e7f06","48e8db19a59a4b8db9457a80bd83f93f","40cef96057744ec4b2ef7de439c27412","ebb4bb78c58f4f30a44fb2296a935ed5","db0fbee234b542afbd3e0c78e31a09c5","6af2c92756c34ce7a20998af5e905b6a","de6bac4a50454de28a725629dbe32cb1","2011dfd9f7c74b088207b589c389f457","cd102423b20641cd96e9467f89299566","34f0f90a07cc44dd8e3ccd9405d2c18e","216e6aa94d8f4346899030b7ff6ca3bb","c822c3752fed4cf0bec8d6574086a002","b84cd7aeeb644517a8ad7f2d33ce3975"],"text":"◯ 0=No aphasia, normal\n◯ 1=Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2=Severe aphasia; all communication is through fragmentary expression, great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension","text_display":"◯ 0=No aphasia, normal\n◯ 1=Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2=Severe aphasia; all communication is through fragmentary expression, great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.63671875,"confidence_rate":0.9985806841034466},{"cnt":[[1132,817],[1168,817],[1168,852],[1132,852]],"region":{"top_left_x":1132,"top_left_y":816,"width":36,"height":37},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1ec81fe7f8dd46878743203d616e7f06","type":"form_field","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1168,826],[1366,826],[1366,852],[1168,852]],"region":{"top_left_x":1167,"top_left_y":826,"width":199,"height":27},"line":55,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"48e8db19a59a4b8db9457a80bd83f93f","type":"text","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"0=No aphasia, normal","text_display":" 0=No aphasia, normal","confidence":0.9776702744898103,"confidence_rate":0.9990970955261256},{"cnt":[[1132,859],[1168,859],[1168,893],[1132,893]],"region":{"top_left_x":1132,"top_left_y":858,"width":36,"height":36},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"40cef96057744ec4b2ef7de439c27412","type":"form_field","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1168,867],[1767,867],[1767,896],[1168,896]],"region":{"top_left_x":1167,"top_left_y":867,"width":600,"height":29},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ebb4bb78c58f4f30a44fb2296a935ed5","type":"text","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"1=Mild to moderate aphasia; some obvious loss of fluency or facility","text_display":" 1=Mild to moderate aphasia; some obvious loss of fluency or facility","confidence":0.7815686620306224,"confidence_rate":0.9966296339340197},{"cnt":[[1187,894],[1677,894],[1677,920],[1187,920]],"region":{"top_left_x":1186,"top_left_y":894,"width":491,"height":27},"line":58,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"db0fbee234b542afbd3e0c78e31a09c5","type":"text","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"of comprehension without significant limitation on ideas","text_display":" of comprehension without significant limitation on ideas","confidence":1,"confidence_rate":1},{"cnt":[[1187,919],[1480,919],[1480,945],[1187,945]],"region":{"top_left_x":1186,"top_left_y":918,"width":295,"height":27},"line":59,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6af2c92756c34ce7a20998af5e905b6a","type":"text","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"expressed on form of expression","text_display":" expressed on form of expression","confidence":1,"confidence_rate":1},{"cnt":[[1132,946],[1166,946],[1166,980],[1132,980]],"region":{"top_left_x":1132,"top_left_y":946,"width":35,"height":35},"line":60,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"de6bac4a50454de28a725629dbe32cb1","type":"form_field","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1165,957],[1707,957],[1707,983],[1165,983]],"region":{"top_left_x":1165,"top_left_y":957,"width":542,"height":27},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2011dfd9f7c74b088207b589c389f457","type":"text","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"2=Severe aphasia; all communication is through fragmentary","text_display":" 2=Severe aphasia; all communication is through fragmentary","confidence":1,"confidence_rate":1},{"cnt":[[1186,983],[1750,983],[1750,1010],[1186,1010]],"region":{"top_left_x":1185,"top_left_y":983,"width":566,"height":28},"line":62,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cd102423b20641cd96e9467f89299566","type":"text","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"expression, great need for inference, questioning, and guessing","text_display":" expression, great need for inference, questioning, and guessing","confidence":0.974609375,"confidence_rate":0.9996218578477726},{"cnt":[[1184,1006],[1683,1006],[1683,1035],[1184,1035]],"region":{"top_left_x":1184,"top_left_y":1006,"width":500,"height":29},"line":63,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"34f0f90a07cc44dd8e3ccd9405d2c18e","type":"text","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"by the listener; listener carries burden of communication","text_display":" by the listener; listener carries burden of communication","confidence":0.9873363971710205,"confidence_rate":0.9997944651625481},{"cnt":[[1132,1036],[1166,1036],[1166,1070],[1132,1070]],"region":{"top_left_x":1132,"top_left_y":1036,"width":35,"height":35},"line":64,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"216e6aa94d8f4346899030b7ff6ca3bb","type":"form_field","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1165,1044],[1644,1044],[1644,1073],[1165,1073]],"region":{"top_left_x":1165,"top_left_y":1044,"width":479,"height":30},"line":65,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c822c3752fed4cf0bec8d6574086a002","type":"text","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"3=Mute, global aphasia; no usable speech or auditory","text_display":" 3=Mute, global aphasia; no usable speech or auditory","confidence":0.63671875,"confidence_rate":0.9921115025946156},{"cnt":[[1184,1072],[1327,1072],[1327,1098],[1184,1098]],"region":{"top_left_x":1184,"top_left_y":1071,"width":144,"height":27},"line":66,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b84cd7aeeb644517a8ad7f2d33ce3975","type":"text","conversion_output":false,"parent_id":"5bbba521ec08410287f2fea058612f66","text":"comprehension","text_display":" comprehension","confidence":1,"confidence_rate":1},{"cnt":[[478,1225],[510,1225],[510,1252],[478,1252]],"region":{"top_left_x":477,"top_left_y":1224,"width":34,"height":28},"line":67,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"649d37636be640eea4acf3969317f638","type":"simple_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"20","text_display":"20","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[529,1126],[1124,1126],[1124,1338],[529,1338]],"region":{"top_left_x":529,"top_left_y":1126,"width":596,"height":212},"line":68,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5ddb52f86d424dbfa63c0a14c1355e1d","type":"complex_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","children_ids":["2e7fde95669549b096f24ac74d6d6fba","352fc0601e5e4123945c9a208d0764af","33b261f11c0842a3a8a58342f4a167ee","e18f82b4887442ab98af4d85cd693857","88d338ad65074e7abeef5630f7bcda21","831e9562368244e4a78d7f468fb5e894","eb88d118a9f3490e82957d9df9ee344a","1030735a2266432d93cad0b225a24f31"],"text":"\\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be normal an adequate sample of speech must be obtained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the clarity of arioulation of spontaneous speech can be rated. Only if the patient is intubated or has other physical barrier to producing speech, may the them be not scored, and the examiner must clearly write an explanation. Do not teil the patlent why helshe is being tested. Coma Score \"2\"\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be normal an adequate sample of speech must be obtained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the clarity of arioulation of spontaneous speech can be rated. Only if the patient is intubated or has other physical barrier to producing speech, may the them be not scored, and the examiner must clearly write an explanation. Do not teil the patlent why helshe is being tested. Coma Score \"2\"\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.14629708854658952,"confidence_rate":0.9939178529068882},{"cnt":[[756,1143],[896,1143],[896,1171],[756,1171]],"region":{"top_left_x":755,"top_left_y":1142,"width":142,"height":30},"line":69,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2e7fde95669549b096f24ac74d6d6fba","type":"text","conversion_output":false,"parent_id":"5ddb52f86d424dbfa63c0a14c1355e1d","text":"(10) Dysarthria","text_display":"(10) Dysarthria","confidence":1,"confidence_rate":1},{"cnt":[[544,1189],[1106,1189],[1106,1215],[544,1215]],"region":{"top_left_x":544,"top_left_y":1189,"width":563,"height":27},"line":70,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"352fc0601e5e4123945c9a208d0764af","type":"text","conversion_output":false,"parent_id":"5ddb52f86d424dbfa63c0a14c1355e1d","text":"If patient is thought to be normal an adequate sample of speech must be","text_display":"\nIf patient is thought to be normal an adequate sample of speech must be","confidence":0.5265716509279628,"confidence_rate":0.9915964579441706},{"cnt":[[538,1211],[1116,1211],[1116,1234],[538,1234]],"region":{"top_left_x":537,"top_left_y":1210,"width":579,"height":25},"line":71,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"33b261f11c0842a3a8a58342f4a167ee","type":"text","conversion_output":false,"parent_id":"5ddb52f86d424dbfa63c0a14c1355e1d","text":"obtained by asking patient to read or repeat words from the attached list. If","text_display":" obtained by asking patient to read or repeat words from the attached list. If","confidence":0.9719445778193254,"confidence_rate":0.999653029783072},{"cnt":[[546,1230],[1105,1230],[1105,1253],[546,1253]],"region":{"top_left_x":545,"top_left_y":1230,"width":561,"height":24},"line":72,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e18f82b4887442ab98af4d85cd693857","type":"text","conversion_output":false,"parent_id":"5ddb52f86d424dbfa63c0a14c1355e1d","text":"the patient has severe aphasia, the clarity of arioulation of spontaneous","text_display":" the patient has severe aphasia, the clarity of arioulation of spontaneous","confidence":0.14629708854658952,"confidence_rate":0.9756586367507482},{"cnt":[[543,1249],[1109,1249],[1109,1272],[543,1272]],"region":{"top_left_x":543,"top_left_y":1249,"width":567,"height":24},"line":73,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"88d338ad65074e7abeef5630f7bcda21","type":"text","conversion_output":false,"parent_id":"5ddb52f86d424dbfa63c0a14c1355e1d","text":"speech can be rated. Only if the patient is intubated or has other physical","text_display":" speech can be rated. Only if the patient is intubated or has other physical","confidence":0.983485283471246,"confidence_rate":0.9997918641046534},{"cnt":[[532,1268],[1120,1268],[1120,1294],[532,1294]],"region":{"top_left_x":532,"top_left_y":1268,"width":589,"height":27},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"831e9562368244e4a78d7f468fb5e894","type":"text","conversion_output":false,"parent_id":"5ddb52f86d424dbfa63c0a14c1355e1d","text":"barrier to producing speech, may the them be not scored, and the examiner","text_display":" barrier to producing speech, may the them be not scored, and the examiner","confidence":0.6344895200782776,"confidence_rate":0.9941844822689282},{"cnt":[[532,1290],[1120,1290],[1120,1316],[532,1316]],"region":{"top_left_x":532,"top_left_y":1290,"width":589,"height":26},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"eb88d118a9f3490e82957d9df9ee344a","type":"text","conversion_output":false,"parent_id":"5ddb52f86d424dbfa63c0a14c1355e1d","text":"must clearly write an explanation. Do not teil the patlent why helshe is being","text_display":" must clearly write an explanation. Do not teil the patlent why helshe is being","confidence":0.4820027366800224,"confidence_rate":0.9912457067450045},{"cnt":[[726,1309],[925,1309],[925,1332],[726,1332]],"region":{"top_left_x":725,"top_left_y":1309,"width":201,"height":24},"line":76,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1030735a2266432d93cad0b225a24f31","type":"text","conversion_output":false,"parent_id":"5ddb52f86d424dbfa63c0a14c1355e1d","text":"tested. Coma Score \"2\"","text_display":" tested. Coma Score \"2\"","confidence":0.9854281602181456,"confidence_rate":0.9994564791746277},{"cnt":[[1130,1120],[1769,1120],[1769,1360],[1130,1360]],"region":{"top_left_x":1129,"top_left_y":1119,"width":641,"height":241},"line":77,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f6778f6f0e60409aab85d3c587eef078","type":"complex_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","children_ids":["ac087b5ae2e445d1a428d7ce1d24a136","3448199bc152482e896892aa952487c2","2535bdd164f342b9af7778dde045e4ba","77c0e1745e504974ac4fa13816eb895e","513292193bbc4b448e240741d65afb7b","d6c8fa9265b74a6eab603bb816b91b52","211558b8323e4b578e42e609d330c567","c77d19b50b454717a971e9c0e42b7f76","b1d235ffaec74a9ea1f0920822b7d497","40fe91667d7448e8aad57ae793e1d256","bb2604a94b8f4f438e776f8cbf5805d8"],"text":"◯ 0=Normal\n◯ \\(1=\\) Mild to moderate; patient slurs at least some words and at worst. can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mutel anarthric\n◯ Intubated or other physical barrier.","text_display":"◯ 0=Normal\n◯ \\(1=\\) Mild to moderate; patient slurs at least some words and at worst. can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mutel anarthric\n◯ Intubated or other physical barrier.","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.5765849535819143,"confidence_rate":0.9979259072699466},{"cnt":[[1132,1124],[1166,1124],[1166,1158],[1132,1158]],"region":{"top_left_x":1132,"top_left_y":1123,"width":35,"height":35},"line":78,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ac087b5ae2e445d1a428d7ce1d24a136","type":"form_field","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1168,1133],[1259,1133],[1259,1158],[1168,1158]],"region":{"top_left_x":1167,"top_left_y":1133,"width":93,"height":25},"line":79,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3448199bc152482e896892aa952487c2","type":"text","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"0=Normal","text_display":" 0=Normal","confidence":0.9677734375,"confidence_rate":0.9974833819085943},{"cnt":[[1132,1167],[1166,1167],[1166,1201],[1132,1201]],"region":{"top_left_x":1132,"top_left_y":1167,"width":35,"height":35},"line":80,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2535bdd164f342b9af7778dde045e4ba","type":"form_field","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1168,1178],[1761,1178],[1761,1204],[1168,1204]],"region":{"top_left_x":1167,"top_left_y":1178,"width":595,"height":27},"line":81,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"77c0e1745e504974ac4fa13816eb895e","type":"text","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"\\(1=\\) Mild to moderate; patient slurs at least some words and at worst.","text_display":" \\(1=\\) Mild to moderate; patient slurs at least some words and at worst.","confidence":0.7550055068948003,"confidence_rate":0.9961044098547783},{"cnt":[[1175,1203],[1517,1203],[1517,1229],[1175,1229]],"region":{"top_left_x":1174,"top_left_y":1202,"width":344,"height":27},"line":82,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"513292193bbc4b448e240741d65afb7b","type":"text","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"can be understood with some difficulty","text_display":" can be understood with some difficulty","confidence":1,"confidence_rate":1},{"cnt":[[1132,1233],[1166,1233],[1166,1267],[1132,1267]],"region":{"top_left_x":1132,"top_left_y":1232,"width":35,"height":35},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d6c8fa9265b74a6eab603bb816b91b52","type":"form_field","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1169,1242],[1739,1242],[1739,1270],[1169,1270]],"region":{"top_left_x":1169,"top_left_y":1242,"width":571,"height":28},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"211558b8323e4b578e42e609d330c567","type":"text","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"2=Severe; patient's speech is so slurred as to be unintelligible in","text_display":" 2=Severe; patient's speech is so slurred as to be unintelligible in","confidence":1,"confidence_rate":1},{"cnt":[[1198,1268],[1764,1268],[1764,1294],[1198,1294]],"region":{"top_left_x":1197,"top_left_y":1268,"width":567,"height":27},"line":85,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c77d19b50b454717a971e9c0e42b7f76","type":"text","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"the absence of or out of proportion to any dysphasia, or is mutel","text_display":" the absence of or out of proportion to any dysphasia, or is mutel","confidence":0.5765849535819143,"confidence_rate":0.9921646775840758},{"cnt":[[1198,1293],[1281,1293],[1281,1316],[1198,1316]],"region":{"top_left_x":1197,"top_left_y":1292,"width":85,"height":24},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b1d235ffaec74a9ea1f0920822b7d497","type":"text","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"anarthric","text_display":" anarthric","confidence":0.99658203125,"confidence_rate":0.9997554710913859},{"cnt":[[1132,1317],[1166,1317],[1166,1354],[1132,1354]],"region":{"top_left_x":1132,"top_left_y":1317,"width":35,"height":38},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"40fe91667d7448e8aad57ae793e1d256","type":"form_field","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1171,1328],[1476,1328],[1476,1357],[1171,1357]],"region":{"top_left_x":1170,"top_left_y":1328,"width":307,"height":29},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bb2604a94b8f4f438e776f8cbf5805d8","type":"text","conversion_output":false,"parent_id":"f6778f6f0e60409aab85d3c587eef078","text":"Intubated or other physical barrier.","text_display":" Intubated or other physical barrier.","confidence":1,"confidence_rate":1},{"cnt":[[478,1391],[508,1391],[508,1418],[478,1418]],"region":{"top_left_x":477,"top_left_y":1390,"width":31,"height":29},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6eeb95c71da2498aac209ffb11920a74","type":"simple_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"21","text_display":"21","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[576,1391],[1076,1391],[1076,1420],[576,1420]],"region":{"top_left_x":575,"top_left_y":1390,"width":502,"height":30},"line":90,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8ee84e9b43e14290afb36a7d13f559e9","type":"simple_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"Explain if intubated or other physical barrier (Dysarthria):","text_display":"Explain if intubated or other physical barrier (Dysarthria):","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1127,1380],[1769,1380],[1769,1426],[1127,1426]],"region":{"top_left_x":1126,"top_left_y":1380,"width":644,"height":47},"line":91,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"135d3b1de2fb4f8caf3b841bca867c86","type":"table_spanning_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"","text_display":"","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1},{"cnt":[[478,1555],[510,1555],[510,1582],[478,1582]],"region":{"top_left_x":477,"top_left_y":1554,"width":34,"height":28},"line":92,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8a62aa884790489f89eb9a15b53451ba","type":"simple_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"22","text_display":"22","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[529,1469],[1123,1467],[1123,1668],[530,1670]],"region":{"top_left_x":528,"top_left_y":1467,"width":596,"height":204},"line":93,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"500c928f64df4503965bd5af26e4451e","type":"complex_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","children_ids":["89c832a12e1549d29c2928b027b5c42c","cfabae5c123248b58c460860b923d416","0184a97ca0384b1e9336df0b759a48ef","f49e9c5584be467cae362bd4626d310a","d848da05dbda43a8ae34a285d1a39e7a","f7e317f5482544d691723a5067787398","74f1466e616d413a9a885b7580dd5b93","1f5173a7a72647e3b1d6f5da84883786"],"text":"\\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumbient information to Identity negiect may be obtained during the proor testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the culaneous stimulil are normal, the score is normal. If the patient has aphasla dur does appear to attend to both sldes, the score is normal. The presence of visual spattal neglect or anosagnosla may also be taken as evidence of abnormailty. Since the abnormality is scored only if present, the item is never untestable. Coma Score \" 2 \".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumbient information to Identity negiect may be obtained during the proor testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the culaneous stimulil are normal, the score is normal. If the patient has aphasla dur does appear to attend to both sldes, the score is normal. The presence of visual spattal neglect or anosagnosla may also be taken as evidence of abnormailty. Since the abnormality is scored only if present, the item is never untestable. Coma Score \" 2 \".\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.08071168698350396,"confidence_rate":0.9885964701485832},{"cnt":[[647,1473],[1005,1473],[1005,1503],[647,1503]],"region":{"top_left_x":646,"top_left_y":1472,"width":360,"height":31},"line":94,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"89c832a12e1549d29c2928b027b5c42c","type":"text","conversion_output":false,"parent_id":"500c928f64df4503965bd5af26e4451e","text":"(11) Extinction and Inattention (Neglect)","text_display":"(11) Extinction and Inattention (Neglect)","confidence":0.99658203125,"confidence_rate":0.9999255718275323},{"cnt":[[544,1522],[1109,1522],[1109,1545],[544,1545]],"region":{"top_left_x":544,"top_left_y":1521,"width":566,"height":25},"line":95,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cfabae5c123248b58c460860b923d416","type":"text","conversion_output":false,"parent_id":"500c928f64df4503965bd5af26e4451e","text":"Sumbient information to Identity negiect may be obtained during the proor","text_display":"\nSumbient information to Identity negiect may be obtained during the proor","confidence":0.08071168698350396,"confidence_rate":0.9682474556376515},{"cnt":[[554,1541],[1098,1541],[1098,1564],[554,1564]],"region":{"top_left_x":553,"top_left_y":1541,"width":546,"height":24},"line":96,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0184a97ca0384b1e9336df0b759a48ef","type":"text","conversion_output":false,"parent_id":"500c928f64df4503965bd5af26e4451e","text":"testing. If the patient has a severe visual loss preventing visual double","text_display":" testing. If the patient has a severe visual loss preventing visual double","confidence":0.988337610826019,"confidence_rate":0.9998496147930668},{"cnt":[[532,1562],[1120,1562],[1120,1583],[532,1583]],"region":{"top_left_x":532,"top_left_y":1561,"width":589,"height":23},"line":97,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f49e9c5584be467cae362bd4626d310a","type":"text","conversion_output":false,"parent_id":"500c928f64df4503965bd5af26e4451e","text":"simultaneous stimulation, and the culaneous stimulil are normal, the score is","text_display":" simultaneous stimulation, and the culaneous stimulil are normal, the score is","confidence":0.4022294892754403,"confidence_rate":0.9889549556828917},{"cnt":[[540,1582],[1112,1582],[1112,1604],[540,1604]],"region":{"top_left_x":540,"top_left_y":1581,"width":572,"height":23},"line":98,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d848da05dbda43a8ae34a285d1a39e7a","type":"text","conversion_output":false,"parent_id":"500c928f64df4503965bd5af26e4451e","text":"normal. If the patient has aphasla dur does appear to attend to both sldes,","text_display":" normal. If the patient has aphasla dur does appear to attend to both sldes,","confidence":0.41551280959696396,"confidence_rate":0.9890820156438105},{"cnt":[[538,1601],[1115,1601],[1115,1624],[538,1624]],"region":{"top_left_x":537,"top_left_y":1601,"width":578,"height":24},"line":99,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f7e317f5482544d691723a5067787398","type":"text","conversion_output":false,"parent_id":"500c928f64df4503965bd5af26e4451e","text":"the score is normal. The presence of visual spattal neglect or anosagnosla","text_display":" the score is normal. The presence of visual spattal neglect or anosagnosla","confidence":0.2765639766157134,"confidence_rate":0.9838618519612521},{"cnt":[[548,1622],[1104,1622],[1104,1646],[548,1646]],"region":{"top_left_x":548,"top_left_y":1621,"width":556,"height":26},"line":100,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"74f1466e616d413a9a885b7580dd5b93","type":"text","conversion_output":false,"parent_id":"500c928f64df4503965bd5af26e4451e","text":"may also be taken as evidence of abnormailty. Since the abnormality is","text_display":" may also be taken as evidence of abnormailty. Since the abnormality is","confidence":0.44268998882383964,"confidence_rate":0.9891936717347161},{"cnt":[[557,1642],[1096,1642],[1096,1665],[557,1665]],"region":{"top_left_x":556,"top_left_y":1641,"width":540,"height":25},"line":101,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1f5173a7a72647e3b1d6f5da84883786","type":"text","conversion_output":false,"parent_id":"500c928f64df4503965bd5af26e4451e","text":"scored only if present, the item is never untestable. Coma Score \" 2 \".","text_display":" scored only if present, the item is never untestable. Coma Score \" 2 \".","confidence":0.45239396641556107,"confidence_rate":0.9900097078217011},{"cnt":[[1127,1459],[1749,1459],[1749,1683],[1127,1683]],"region":{"top_left_x":1126,"top_left_y":1459,"width":623,"height":224},"line":102,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0e98b7c4120b416f8504a1008d427823","type":"complex_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","children_ids":["46dd8b039c724167b86dfe48d8601147","6c446c44014c4890afce5654894c70ce","73ba789245164700b21d19f6c1e95a84","1ae8bfd92fa44ceab5eab5af3cda9145","a0e2be67eca34e70b39fdbf098ab0e6f","886ff5c3541049528b695ebd257de071","ac90773fe863401f93be1e52a0ce1bea","35c5bd427acc4a5488e8deca8b6db220","e9fab059e3d74d91b499cb760fe9e03e","d18c554cdbe54d53b9fcbeb5b1c0eb55"],"text":"◯ \\(0=\\) No abnormality\n◯ \\(1=\\) Visual, tactile, auditory, spatial, or personal inattention or extinction to bilateral simultaneous stimulation in one of the sensory modalities\n◯ 2=Profound hemi-inattention or hemi-inattention to more than one modality; does not recognize own hand or orients to only one side of space","text_display":"◯ \\(0=\\) No abnormality\n◯ \\(1=\\) Visual, tactile, auditory, spatial, or personal inattention or extinction to bilateral simultaneous stimulation in one of the sensory modalities\n◯ 2=Profound hemi-inattention or hemi-inattention to more than one modality; does not recognize own hand or orients to only one side of space","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.48564561311786747,"confidence_rate":0.9950234242473082},{"cnt":[[1132,1463],[1166,1463],[1166,1499],[1132,1499]],"region":{"top_left_x":1132,"top_left_y":1463,"width":35,"height":36},"line":103,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"46dd8b039c724167b86dfe48d8601147","type":"form_field","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1166,1473],[1327,1473],[1327,1501],[1166,1501]],"region":{"top_left_x":1166,"top_left_y":1472,"width":162,"height":30},"line":104,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6c446c44014c4890afce5654894c70ce","type":"text","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"\\(0=\\) No abnormality","text_display":" \\(0=\\) No abnormality","confidence":0.48564561311786747,"confidence_rate":0.9661906532984239},{"cnt":[[1132,1507],[1168,1507],[1168,1542],[1132,1542]],"region":{"top_left_x":1132,"top_left_y":1506,"width":36,"height":37},"line":105,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"73ba789245164700b21d19f6c1e95a84","type":"form_field","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1168,1516],[1693,1516],[1693,1545],[1168,1545]],"region":{"top_left_x":1167,"top_left_y":1516,"width":527,"height":30},"line":106,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1ae8bfd92fa44ceab5eab5af3cda9145","type":"text","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"\\(1=\\) Visual, tactile, auditory, spatial, or personal inattention or","text_display":" \\(1=\\) Visual, tactile, auditory, spatial, or personal inattention or","confidence":0.9887747764587402,"confidence_rate":0.9998364090078444},{"cnt":[[1198,1544],[1720,1544],[1720,1567],[1198,1567]],"region":{"top_left_x":1197,"top_left_y":1543,"width":524,"height":24},"line":107,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a0e2be67eca34e70b39fdbf098ab0e6f","type":"text","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"extinction to bilateral simultaneous stimulation in one of the","text_display":" extinction to bilateral simultaneous stimulation in one of the","confidence":1,"confidence_rate":1},{"cnt":[[1198,1568],[1368,1568],[1368,1594],[1198,1594]],"region":{"top_left_x":1197,"top_left_y":1568,"width":172,"height":27},"line":108,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"886ff5c3541049528b695ebd257de071","type":"text","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"sensory modalities","text_display":" sensory modalities","confidence":1,"confidence_rate":1},{"cnt":[[1132,1596],[1166,1596],[1166,1632],[1132,1632]],"region":{"top_left_x":1132,"top_left_y":1595,"width":35,"height":38},"line":109,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ac90773fe863401f93be1e52a0ce1bea","type":"form_field","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1165,1605],[1745,1605],[1745,1632],[1165,1632]],"region":{"top_left_x":1165,"top_left_y":1605,"width":580,"height":28},"line":110,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"35c5bd427acc4a5488e8deca8b6db220","type":"text","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"2=Profound hemi-inattention or hemi-inattention to more than one","text_display":" 2=Profound hemi-inattention or hemi-inattention to more than one","confidence":0.9751095771789551,"confidence_rate":0.999634770662493},{"cnt":[[1198,1634],[1737,1634],[1737,1660],[1198,1660]],"region":{"top_left_x":1197,"top_left_y":1633,"width":540,"height":27},"line":111,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e9fab059e3d74d91b499cb760fe9e03e","type":"text","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"modality; does not recognize own hand or orients to only one","text_display":" modality; does not recognize own hand or orients to only one","confidence":1,"confidence_rate":1},{"cnt":[[1196,1656],[1319,1656],[1319,1682],[1196,1682]],"region":{"top_left_x":1196,"top_left_y":1655,"width":124,"height":27},"line":112,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d18c554cdbe54d53b9fcbeb5b1c0eb55","type":"text","conversion_output":false,"parent_id":"0e98b7c4120b416f8504a1008d427823","text":"side of space","text_display":" side of space","confidence":1,"confidence_rate":1},{"cnt":[[478,1777],[508,1777],[508,1803],[478,1803]],"region":{"top_left_x":477,"top_left_y":1777,"width":31,"height":26},"line":113,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"899b9a56643d414ba2b5d4c0fb22c01f","type":"simple_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","text":"23","text_display":"23","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[529,1718],[1112,1718],[1112,1862],[529,1862]],"region":{"top_left_x":529,"top_left_y":1718,"width":583,"height":144},"line":114,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0b99501c0181469da96f107b720fa82f","type":"complex_cell","conversion_output":false,"parent_id":"0fd68b8bd140456db33552b464b8372e","children_ids":["1c512bd0d4dd49ea954bdef57cb899e1","012c59f3c1ac4f8999c822233cbb0748","f63781594b024368914771dd4b3e8218","6a7f1ac71b1440a2aab159fb55c1ea32","cde4f887d4774fe6ab13bfcd4e68ff21"],"text":"\\begin{tabular}{l}\nDid NIHSS increase by \\(\\geq 2\\) points AND NIHSS score is now >5? \\\\\nIf YES, consider treating patient with IV rtPA as standard of care and unblinding of treatment assignment if appropriate. Note that patient will continue to be followed in the PRISMS trial regardless of decision. 5\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nDid NIHSS increase by \\(\\geq 2\\) points AND NIHSS score is now >5? \\\\\nIf YES, consider treating patient with IV rtPA as standard of care and unblinding of treatment assignment if appropriate. 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duties and activities\n◯ (2) Slight disability, unable to carry out all previous activities but able to look after own affairs without assistance\n◯ (3) Moderate disability requiring some help, but able to walk without assistance\n◯ (4) Moderately severe disability, unable to walk without assistance and unable to attend to own bodily needs without assistance\n◯ (5) Severe disability, bedridden, incontinent, and requiring constant nursing care and attention \\\\\n\\hline 2 & For response 2 above, specify the previous activities that can no longer be carried out: & \\\\\n\\hline 3 & \\begin{tabular}{l}\nName of assessor: \\\\\nThe assessor must be a study team member who has completed mRS certification.\n\\end{tabular} & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 1 & Modified Rankin Scale: & ◯ (D) No symptoms at all\n◯ (1) No significant disability despite symptoms; able to carry out all usual duties and activities\n◯ (2) Slight disability, 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It has become common practice","text_display":"\n\nNote: The scale presented here is based on the original article by Jennett and Bond. It has become common practice","confidence":0.9951171875,"confidence_rate":0.9999588683049504},{"cnt":[[541,662],[1717,662],[1717,696],[541,696]],"region":{"top_left_x":541,"top_left_y":661,"width":1176,"height":36},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"04df3e5fd8a54518ad6120c46775e526","type":"text","conversion_output":true,"text":"in elinical trial administration, however, to use a modified version that places the scores in reverse order (i.e., \"good","text_display":" in elinical trial administration, however, to use a modified version that places the scores in reverse order (i.e., \"good","confidence":0.3537312559245381,"confidence_rate":0.9917861589970511},{"cnt":[[541,694],[1008,694],[1008,728],[541,728]],"region":{"top_left_x":541,"top_left_y":693,"width":467,"height":36},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8393bf7231f840aca55e63e83e75c24c","type":"text","conversion_output":true,"text":"recovery\" = 1, \"moderate disability\" =2, etc.).","text_display":" recovery\" = 1, \"moderate disability\" =2, etc.).","confidence":0.5821059381123632,"confidence_rate":0.9896481297466071},{"cnt":[[535,844],[1734,844],[1734,1519],[535,1519]],"region":{"top_left_x":534,"top_left_y":844,"width":1200,"height":675},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3e613de6ed774df7a3827951ba4e6aa7","type":"table","conversion_output":true,"children_ids":["8d63fa046c6c429586c173143b053223","2149133b1ecd4e6ca85c18955be3c75f","2c8e608f5a4b453e91b585e1848b06fc","b54df519c8cb4ba985f1bd70ee146edf","d61332c2a5d448abb46595ea844bada4","caaf59356afd4e7ba390f7d5ec8df67e","aef6fc3853e341caac2d88e18239ec6b","6e367bcd34d64908a0fe5de606d31f06","7af5a76f5cf14e9d8aa6123d11b17568","d3bd1cde54f043e48e01b8ad55bcc756","f250c72f629c4b9dabce9a1438d61df1","aca765fa2e7140c581e7260a5b6f490a","8dc4a6c78e464c0eafb5f0aa7f9df868","6f08498020db4bc7b52ad6c92efa42b9","d22585e00b16461a82e7a4b9a9aa96ab","5ae5517895de4acbadfdae4be373d4fb","e846fd548fbe489ebbc230218a0172be","bf6322d00e3c436198d0259714e8fb96","1d96af09f6a2455ba030fca8e24b9dd8","be8ba417a9c84ebc9b997055bd2f51bc"],"text":"\\begin{tabular}{|l|l|}\n\\hline Score & Description \\\\\n\\hline 1 & DEATH \\\\\n\\hline 2 & PERSISTENT VEGETATIVE STATE Patient exhibits no obvious cortical function. \\\\\n\\hline 3 & \\begin{tabular}{l}\nSEVERE DISABILITY \\\\\n(Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both.\n\\end{tabular} \\\\\n\\hline 4 & \\begin{tabular}{l}\nMODERATE DISABILITY \\\\\n(Disabled but independent). Patient is independent as far as daily life is concerned. The disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as intellectual and memory deficits and personality changes.\n\\end{tabular} \\\\\n\\hline 5 & \\begin{tabular}{l}\nGOOD RECOVERY \\\\\nResumption of normal activities even though there may be minor neurological or psychological deficits.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Score & Description \\\\\n\\hline 1 & DEATH \\\\\n\\hline 2 & PERSISTENT VEGETATIVE STATE Patient exhibits no obvious cortical function. \\\\\n\\hline 3 & \\begin{tabular}{l}\nSEVERE DISABILITY \\\\\n(Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both.\n\\end{tabular} \\\\\n\\hline 4 & \\begin{tabular}{l}\nMODERATE DISABILITY \\\\\n(Disabled but independent). Patient is independent as far as daily life is concerned. The disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as intellectual and memory deficits and personality changes.\n\\end{tabular} \\\\\n\\hline 5 & \\begin{tabular}{l}\nGOOD RECOVERY \\\\\nResumption of normal activities even though there may be minor neurological or psychological deficits.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.9658203125,"confidence_rate":0.999947269448197},{"cnt":[[536,844],[625,844],[625,1519],[536,1519]],"region":{"top_left_x":535,"top_left_y":844,"width":91,"height":676},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8d63fa046c6c429586c173143b053223","type":"table_column","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"","text_display":""},{"cnt":[[716,844],[1722,844],[1722,1519],[716,1519]],"region":{"top_left_x":716,"top_left_y":844,"width":1006,"height":676},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2149133b1ecd4e6ca85c18955be3c75f","type":"table_column","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"","text_display":""},{"cnt":[[534,844],[1735,844],[1735,882],[534,882]],"region":{"top_left_x":534,"top_left_y":844,"width":1202,"height":38},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2c8e608f5a4b453e91b585e1848b06fc","type":"table_row","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"","text_display":""},{"cnt":[[534,908],[1735,908],[1735,944],[534,944]],"region":{"top_left_x":534,"top_left_y":907,"width":1202,"height":37},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b54df519c8cb4ba985f1bd70ee146edf","type":"table_row","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"","text_display":""},{"cnt":[[534,991],[1735,989],[1736,1061],[534,1062]],"region":{"top_left_x":533,"top_left_y":989,"width":1203,"height":74},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d61332c2a5d448abb46595ea844bada4","type":"table_row","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"","text_display":""},{"cnt":[[534,1107],[1734,1107],[1734,1210],[534,1210]],"region":{"top_left_x":534,"top_left_y":1106,"width":1200,"height":105},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"caaf59356afd4e7ba390f7d5ec8df67e","type":"table_row","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"","text_display":""},{"cnt":[[534,1250],[1735,1250],[1735,1384],[534,1384]],"region":{"top_left_x":534,"top_left_y":1249,"width":1202,"height":135},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"aef6fc3853e341caac2d88e18239ec6b","type":"table_row","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"","text_display":""},{"cnt":[[534,1425],[1735,1425],[1735,1519],[534,1519]],"region":{"top_left_x":534,"top_left_y":1424,"width":1202,"height":96},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6e367bcd34d64908a0fe5de606d31f06","type":"table_row","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"","text_display":""},{"cnt":[[541,847],[622,847],[622,877],[541,877]],"region":{"top_left_x":540,"top_left_y":847,"width":82,"height":30},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7af5a76f5cf14e9d8aa6123d11b17568","type":"simple_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"Score","text_display":"Score","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[723,847],[879,847],[879,880],[723,880]],"region":{"top_left_x":723,"top_left_y":847,"width":157,"height":34},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d3bd1cde54f043e48e01b8ad55bcc756","type":"simple_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"Description","text_display":"Description","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[589,913],[606,913],[606,940],[589,940]],"region":{"top_left_x":589,"top_left_y":912,"width":18,"height":29},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f250c72f629c4b9dabce9a1438d61df1","type":"simple_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"1","text_display":"1","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[723,909],[814,909],[814,939],[723,939]],"region":{"top_left_x":723,"top_left_y":909,"width":92,"height":30},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"aca765fa2e7140c581e7260a5b6f490a","type":"simple_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"DEATH","text_display":"DEATH","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[577,997],[610,997],[610,1028],[577,1028]],"region":{"top_left_x":576,"top_left_y":996,"width":34,"height":32},"line":20,"column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VEGETATIVE STATE Patient exhibits no obvious cortical function.","text_display":"PERSISTENT VEGETATIVE STATE Patient exhibits no obvious cortical function.","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9921972721349448,"confidence_rate":0.9999232056113043},{"cnt":[[723,999],[1127,999],[1127,1026],[723,1026]],"region":{"top_left_x":723,"top_left_y":998,"width":404,"height":29},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5ec9020e7a7646679fdb4a639fe82870","type":"text","conversion_output":false,"parent_id":"6f08498020db4bc7b52ad6c92efa42b9","text":"PERSISTENT VEGETATIVE STATE","text_display":"PERSISTENT VEGETATIVE STATE","confidence":1,"confidence_rate":1},{"cnt":[[723,1026],[1182,1026],[1182,1055],[723,1055]],"region":{"top_left_x":723,"top_left_y":1026,"width":459,"height":30},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5009e68bf3ae4d3b9b787f5809a86d1a","type":"text","conversion_output":false,"parent_id":"6f08498020db4bc7b52ad6c92efa42b9","text":"Patient exhibits no obvious cortical function.","text_display":" Patient exhibits no obvious cortical function.","confidence":0.9921972721349448,"confidence_rate":0.9998464171199869},{"cnt":[[575,1110],[608,1110],[608,1143],[575,1143]],"region":{"top_left_x":575,"top_left_y":1110,"width":33,"height":34},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d22585e00b16461a82e7a4b9a9aa96ab","type":"simple_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"3","text_display":"3","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[720,1109],[1720,1109],[1720,1207],[720,1207]],"region":{"top_left_x":719,"top_left_y":1108,"width":1001,"height":99},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5ae5517895de4acbadfdae4be373d4fb","type":"complex_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","children_ids":["9d82327cd6a0424cba5fa0b96d00fd81","b09a8e8678574b5bb40e87ce37c85873","7efc32f6dbbd4fcf992c7eeeecf42f14"],"text":"\\begin{tabular}{l}\nSEVERE DISABILITY \\\\\n(Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nSEVERE DISABILITY \\\\\n(Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both.\n\\end{tabular}","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9999796402394503},{"cnt":[[723,1112],[972,1112],[972,1141],[723,1141]],"region":{"top_left_x":723,"top_left_y":1112,"width":250,"height":30},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9d82327cd6a0424cba5fa0b96d00fd81","type":"text","conversion_output":false,"parent_id":"5ae5517895de4acbadfdae4be373d4fb","text":"SEVERE DISABILITY","text_display":"SEVERE DISABILITY","confidence":1,"confidence_rate":1},{"cnt":[[723,1141],[1718,1141],[1718,1176],[723,1176]],"region":{"top_left_x":723,"top_left_y":1141,"width":996,"height":35},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b09a8e8678574b5bb40e87ce37c85873","type":"text","conversion_output":false,"parent_id":"5ae5517895de4acbadfdae4be373d4fb","text":"(Conscious but disabled). Patient depends upon others for daily support due to mental or physical","text_display":"\n(Conscious but disabled). Patient depends upon others for daily support due to mental or physical","confidence":1,"confidence_rate":1},{"cnt":[[723,1171],[907,1171],[907,1203],[723,1203]],"region":{"top_left_x":723,"top_left_y":1170,"width":184,"height":34},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7efc32f6dbbd4fcf992c7eeeecf42f14","type":"text","conversion_output":false,"parent_id":"5ae5517895de4acbadfdae4be373d4fb","text":"disability or both.","text_display":" disability or both.","confidence":0.99853515625,"confidence_rate":0.9999389219619019},{"cnt":[[577,1256],[610,1256],[610,1291],[577,1291]],"region":{"top_left_x":576,"top_left_y":1256,"width":34,"height":35},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e846fd548fbe489ebbc230218a0172be","type":"simple_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"4","text_display":"4","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[720,1253],[1629,1253],[1629,1379],[720,1379]],"region":{"top_left_x":719,"top_left_y":1253,"width":910,"height":126},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bf6322d00e3c436198d0259714e8fb96","type":"complex_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","children_ids":["ec8447322a4243229fe77da7b0ab1d01","d0e4ca25677e48a8a266914e99605389","8af5c788c02243dd8f029a555a804c62","75b0f847d1b843e395c5824ee59f0a89"],"text":"\\begin{tabular}{l}\nMODERATE DISABILITY \\\\\n(Disabled but independent). Patient is independent as far as daily life is concerned. The disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as intellectual and memory deficits and personality changes.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nMODERATE DISABILITY \\\\\n(Disabled but independent). Patient is independent as far as daily life is concerned. The disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as intellectual and memory deficits and personality changes.\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9658203125,"confidence_rate":0.9998292204654666},{"cnt":[[723,1256],[1017,1256],[1017,1286],[723,1286]],"region":{"top_left_x":723,"top_left_y":1256,"width":294,"height":30},"line":31,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ec8447322a4243229fe77da7b0ab1d01","type":"text","conversion_output":false,"parent_id":"bf6322d00e3c436198d0259714e8fb96","text":"MODERATE DISABILITY","text_display":"MODERATE DISABILITY","confidence":0.9970703125,"confidence_rate":0.9998777579957132},{"cnt":[[723,1286],[1622,1286],[1622,1318],[723,1318]],"region":{"top_left_x":723,"top_left_y":1285,"width":899,"height":34},"line":32,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d0e4ca25677e48a8a266914e99605389","type":"text","conversion_output":false,"parent_id":"bf6322d00e3c436198d0259714e8fb96","text":"(Disabled but independent). Patient is independent as far as daily life is concerned. The","text_display":"\n(Disabled but independent). Patient is independent as far as daily life is concerned. The","confidence":1,"confidence_rate":1},{"cnt":[[723,1315],[1627,1315],[1627,1348],[723,1348]],"region":{"top_left_x":723,"top_left_y":1314,"width":905,"height":34},"line":33,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8af5c788c02243dd8f029a555a804c62","type":"text","conversion_output":false,"parent_id":"bf6322d00e3c436198d0259714e8fb96","text":"disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as","text_display":" disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as","confidence":1,"confidence_rate":1},{"cnt":[[723,1346],[1307,1346],[1307,1377],[723,1377]],"region":{"top_left_x":723,"top_left_y":1345,"width":585,"height":32},"line":34,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"75b0f847d1b843e395c5824ee59f0a89","type":"text","conversion_output":false,"parent_id":"bf6322d00e3c436198d0259714e8fb96","text":"intellectual and memory deficits and personality changes.","text_display":" intellectual and memory deficits and personality changes.","confidence":0.9658203125,"confidence_rate":0.9994392302905138},{"cnt":[[575,1432],[610,1432],[610,1461],[575,1461]],"region":{"top_left_x":575,"top_left_y":1431,"width":35,"height":31},"line":35,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1d96af09f6a2455ba030fca8e24b9dd8","type":"simple_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","text":"5","text_display":"5","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[720,1428],[1694,1428],[1694,1519],[720,1519]],"region":{"top_left_x":719,"top_left_y":1428,"width":976,"height":92},"line":36,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"be8ba417a9c84ebc9b997055bd2f51bc","type":"complex_cell","conversion_output":false,"parent_id":"3e613de6ed774df7a3827951ba4e6aa7","children_ids":["5cbb633d40274eae9c4be38b01f56db3","2ff17108eb6a490c904a7ef9894869ec","3854d179414a494a9950f07f4b28324e"],"text":"\\begin{tabular}{l}\nGOOD 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The index should be used as a record of what a patient does, not as a record of what a patient could do.","text_display":"\n1. The index should be used as a record of what a patient does, not as a record of what a patient could do.","confidence":1,"confidence_rate":1},{"cnt":[[584,625],[1725,625],[1725,660],[584,660]],"region":{"top_left_x":584,"top_left_y":625,"width":1142,"height":35},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"825a50e72b544ce78a57818334cc955e","type":"text","conversion_output":true,"text":"2. The main aim is to establish degree of independence from any help, physical or verbal, however minor","text_display":"\n2. 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The need for supervision renders the patient not independent.","confidence":1,"confidence_rate":1},{"cnt":[[584,718],[1691,718],[1691,750],[584,750]],"region":{"top_left_x":584,"top_left_y":717,"width":1107,"height":33},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"88a3738a5cba457495b8947780179d6e","type":"text","conversion_output":true,"text":"4. A patient's performance should be established using the best available evidence. Asking the patient,","text_display":"\n4. A patient's performance should be established using the best available evidence. Asking the patient,","confidence":1,"confidence_rate":1},{"cnt":[[632,748],[1693,748],[1693,780],[632,780]],"region":{"top_left_x":631,"top_left_y":747,"width":1062,"height":33},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"506c0a25a8f64c68a93981e0b88e366a","type":"text","conversion_output":true,"text":"fiiends/relatives and nurses are the usual sources, but direct observation and common sense are also","text_display":" fiiends/relatives and nurses are the usual sources, but direct observation and common sense are also","confidence":0.6201494487468153,"confidence_rate":0.9954599109940456},{"cnt":[[632,778],[1149,778],[1149,814],[632,814]],"region":{"top_left_x":631,"top_left_y":777,"width":519,"height":38},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"42fe59081c33470fbd46361e1182926a","type":"text","conversion_output":true,"text":"important. However direct testing is not needed.","text_display":" important. 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12","confidence":1,"confidence_rate":1},{"cnt":[[924,408],[1315,408],[1315,449],[924,449]],"region":{"top_left_x":923,"top_left_y":408,"width":392,"height":42},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"837b09105d3c446fbaf3f1086bd6801a","type":"text","conversion_output":true,"parent_id":"0c4b98ad17ef4b7996d1db93730aa579","text":"10 Meter Walk Test","text_display":" \\\\ 10 Meter Walk Test}","confidence":0.99951171875,"confidence_rate":0.9999778002237774},{"cnt":[[451,486],[1635,486],[1635,526],[451,526]],"region":{"top_left_x":451,"top_left_y":485,"width":1184,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9b021b89a8b430ba8d25eefa34bedf7","type":"text","conversion_output":true,"text":"Description: The 10 meter walk test \\((10 mWT )\\) is a measure of walking speed.","text_display":"\n\nDescription: The 10 meter walk test \\((10 mWT )\\) is a measure of walking speed.","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[451,541],[1669,541],[1669,587],[451,587]],"region":{"top_left_x":451,"top_left_y":541,"width":1219,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ab215ed2fd148819f100c8cb2be5c03","type":"text","conversion_output":true,"text":"Equipment: Utilize a quiet hallway or open space at least 14 meters long, digital","text_display":"\nEquipment: Utilize a quiet hallway or open space at least 14 meters long, digital","confidence":1,"confidence_rate":1},{"cnt":[[451,584],[1751,584],[1751,623],[451,623]],"region":{"top_left_x":451,"top_left_y":584,"width":1300,"height":40},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33361f29c1a240ca90455f13427590d8","type":"text","conversion_output":true,"text":"stopwatch, clipboard, tape measure, and tape to mark standardized course layout, and","text_display":" stopwatch, clipboard, tape measure, and tape to mark standardized course layout, and","confidence":1,"confidence_rate":1},{"cnt":[[451,623],[582,623],[582,655],[451,655]],"region":{"top_left_x":451,"top_left_y":623,"width":132,"height":33},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee75fd199f1044af93ad95917f83bff5","type":"text","conversion_output":true,"text":"2 chairs.","text_display":" 2 chairs.","confidence":1,"confidence_rate":1},{"cnt":[[451,679],[1755,679],[1755,720],[451,720]],"region":{"top_left_x":451,"top_left_y":678,"width":1305,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47c18073abab4e5b882cddae19695450","type":"text","conversion_output":true,"text":"Bracing and Assistive Device: The subject should be wearing comfortable flat shoes","text_display":"\n\nBracing and Assistive Device: The subject should be wearing comfortable flat shoes","confidence":1,"confidence_rate":1},{"cnt":[[451,718],[1708,718],[1708,758],[451,758]],"region":{"top_left_x":451,"top_left_y":717,"width":1258,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d3e92600dd146999e09b4cae315b1f2","type":"text","conversion_output":true,"text":"or shoes with a heel less than \\(1 / 2\\) inch. Have the subject perform this test with their","text_display":" or shoes with a heel less than \\(1 / 2\\) inch. Have the subject perform this test with their","confidence":0.933262825012207,"confidence_rate":0.9992654994630993},{"cnt":[[451,756],[1781,756],[1781,797],[451,797]],"region":{"top_left_x":451,"top_left_y":756,"width":1331,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa848a7fb03c4bb087ff4b6d02e06003","type":"text","conversion_output":true,"text":"most often used assistive device and orthotics. Note the specific type of assistive device","text_display":" most often used assistive device and orthotics. Note the specific type of assistive device","confidence":1,"confidence_rate":1},{"cnt":[[451,797],[1145,797],[1145,831],[451,831]],"region":{"top_left_x":451,"top_left_y":797,"width":695,"height":35},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0314c8d4a9da4b30b9b4ac9bcae7f7de","type":"text","conversion_output":true,"text":"and orthotics utilized on the source document.","text_display":" and orthotics utilized on the source document.","confidence":1,"confidence_rate":1},{"cnt":[[447,846],[1197,846],[1197,896],[447,896]],"region":{"top_left_x":446,"top_left_y":846,"width":751,"height":50},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe75eb1e284c455d9de197a713dc8ed4","type":"section_header","conversion_output":false,"children_ids":["cc475a94ed22426f826f613479f9e632"],"text":"","text_display":""},{"cnt":[[451,853],[1192,853],[1192,892],[451,892]],"region":{"top_left_x":451,"top_left_y":852,"width":742,"height":40},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc475a94ed22426f826f613479f9e632","type":"text","conversion_output":true,"parent_id":"fe75eb1e284c455d9de197a713dc8ed4","text":"Physical Assistance Provided During Testing:","text_display":"\n\n\\section*{Physical Assistance Provided During Testing:}","confidence":1,"confidence_rate":1},{"cnt":[[451,911],[1680,911],[1680,950],[451,950]],"region":{"top_left_x":451,"top_left_y":910,"width":1230,"height":40},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56507723748e42dea1fe783a01f8c544","type":"text","conversion_output":true,"text":"Physical assistance may be provided as needed to maintain safety and stability. If","text_display":"\n\nPhysical assistance may be provided as needed to maintain safety and stability. If","confidence":1,"confidence_rate":1},{"cnt":[[451,950],[1723,950],[1723,990],[451,990]],"region":{"top_left_x":451,"top_left_y":949,"width":1273,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79c664fc8bab4c29bf9629c5bd1691a3","type":"text","conversion_output":true,"text":"additional assistance is needed, a non-blinded member of the investigation team can","text_display":" additional assistance is needed, a non-blinded member of the investigation team can","confidence":1,"confidence_rate":1},{"cnt":[[451,988],[1661,988],[1661,1029],[451,1029]],"region":{"top_left_x":451,"top_left_y":988,"width":1210,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"deb00bf794034797bd3701fe9573764a","type":"text","conversion_output":true,"text":"provide the additional assistance. No assistance can be provided for paretic limb","text_display":" provide the additional assistance. No assistance can be provided for paretic limb","confidence":1,"confidence_rate":1},{"cnt":[[451,1027],[1661,1027],[1661,1068],[451,1068]],"region":{"top_left_x":451,"top_left_y":1026,"width":1210,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0628de3e9f834f51827fe649d50f6e9b","type":"text","conversion_output":true,"text":"advancement. A gait belt may be used during the test. The amount of assistance","text_display":" advancement. A gait belt may be used during the test. The amount of assistance","confidence":1,"confidence_rate":1},{"cnt":[[451,1066],[1747,1066],[1747,1106],[451,1106]],"region":{"top_left_x":451,"top_left_y":1065,"width":1296,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc2cb483d41541778f8bcc6c7333d6af","type":"text","conversion_output":true,"text":"provided will be recorded with assignment of a Functional Ambulation Category (FAC).","text_display":" provided will be recorded with assignment of a Functional Ambulation Category (FAC).","confidence":1,"confidence_rate":1},{"cnt":[[451,1104],[1023,1104],[1023,1145],[451,1145]],"region":{"top_left_x":451,"top_left_y":1104,"width":572,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"205b08fcd1a64220b145946532c4bf8f","type":"text","conversion_output":true,"text":"See FAC for description of procedure.","text_display":" See FAC for description of procedure.","confidence":1,"confidence_rate":1},{"cnt":[[447,1160],[786,1160],[786,1201],[447,1201]],"region":{"top_left_x":446,"top_left_y":1160,"width":341,"height":41},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f52a6e30e724f84a9f6e8087e441013","type":"section_header","conversion_output":false,"children_ids":["2624450f94b54e4c8d918087c0e15078"],"text":"","text_display":""},{"cnt":[[451,1164],[784,1164],[784,1197],[451,1197]],"region":{"top_left_x":451,"top_left_y":1164,"width":334,"height":33},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2624450f94b54e4c8d918087c0e15078","type":"text","conversion_output":true,"parent_id":"5f52a6e30e724f84a9f6e8087e441013","text":"Test Administration:","text_display":"\n\n\\section*{Test Administration:}","confidence":0.99951171875,"confidence_rate":0.9999804641709025},{"cnt":[[451,1220],[1721,1220],[1721,1259],[451,1259]],"region":{"top_left_x":451,"top_left_y":1220,"width":1270,"height":39},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4691b906d984855bdb02dd4069fc9fe","type":"text","conversion_output":true,"text":"Course Layout: The walking Course is established indoors on a level, non-carpeted","text_display":"\n\nCourse Layout: The walking Course is established indoors on a level, non-carpeted","confidence":1,"confidence_rate":1},{"cnt":[[451,1259],[1768,1259],[1768,1300],[451,1300]],"region":{"top_left_x":451,"top_left_y":1258,"width":1318,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"522ad704fcfb4df7b01a2249ad695cc6","type":"text","conversion_output":true,"text":"surface measuring a length of 14 meters. The course is marked with tape at 0 meters, 2","text_display":" surface measuring a length of 14 meters. The course is marked with tape at 0 meters, 2","confidence":1,"confidence_rate":1},{"cnt":[[451,1298],[1691,1298],[1691,1336],[451,1336]],"region":{"top_left_x":451,"top_left_y":1297,"width":1240,"height":40},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36da6d4acc5b41698b6ce6a1d3b0cfaf","type":"text","conversion_output":true,"text":"meters, 12 meters, and 14 meters. 2 chairs can be placed near the 0 meter and 14","text_display":" meters, 12 meters, and 14 meters. 2 chairs can be placed near the 0 meter and 14","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[451,1336],[638,1336],[638,1371],[451,1371]],"region":{"top_left_x":451,"top_left_y":1336,"width":188,"height":35},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8163c11fa224b6c947d2faf24026ebf","type":"text","conversion_output":true,"text":"meter mark.","text_display":" meter mark.","confidence":1,"confidence_rate":1},{"cnt":[[666,1416],[1568,1416],[1568,1577],[666,1577]],"region":{"top_left_x":666,"top_left_y":1415,"width":903,"height":162},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8aeec80d4a144779b010ec2ff41407f","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-089.jpg?height=162&width=903&top_left_y=1415&top_left_x=666)"},{"cnt":[[451,1624],[1764,1624],[1764,1665],[451,1665]],"region":{"top_left_x":451,"top_left_y":1624,"width":1313,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f3121b180984a13a23a8afa4767b1f4","type":"text","conversion_output":true,"text":"1. Instruct the subject in the goal of the 10 meter walk test while the subject is seated:","text_display":"\n1. Instruct the subject in the goal of the 10 meter walk test while the subject is seated:","confidence":1,"confidence_rate":1},{"cnt":[[518,1684],[1785,1684],[1785,1725],[518,1725]],"region":{"top_left_x":517,"top_left_y":1684,"width":1269,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"484a3e3f38bd45058e1a92ed2aeb4cb0","type":"text","conversion_output":true,"text":"\"You are going to walk a distance of about \\(4 0\\) feet. We will repeat this distance","text_display":"\n\"You are going to walk a distance of about \\(4 0\\) feet. We will repeat this distance","confidence":0.9931697845458984,"confidence_rate":0.9999246880213992},{"cnt":[[516,1727],[1734,1727],[1734,1768],[516,1768]],"region":{"top_left_x":515,"top_left_y":1727,"width":1219,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"707767b71ff7447b9a0e17942bd14ffa","type":"text","conversion_output":true,"text":"four times. The first two times will be completed at your comfortable pace,","text_display":" four times. The first two times will be completed at your comfortable pace,","confidence":1,"confidence_rate":1},{"cnt":[[516,1770],[1699,1770],[1699,1811],[516,1811]],"region":{"top_left_x":515,"top_left_y":1770,"width":1185,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4903f79acd649969350a2d8b90eb23c","type":"text","conversion_output":true,"text":"the final two times you will walk as quickly and safely as you can. Do you","text_display":" the final two times you will walk as quickly and safely as you can. Do you","confidence":1,"confidence_rate":1},{"cnt":[[516,1813],[874,1813],[874,1854],[516,1854]],"region":{"top_left_x":515,"top_left_y":1813,"width":360,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e77f43ad9cf346318ea3c17b7dd2746a","type":"text","conversion_output":true,"text":"have any questions?\"","text_display":" have any questions?\"","confidence":1,"confidence_rate":1},{"cnt":[[451,1869],[1259,1869],[1259,1912],[451,1912]],"region":{"top_left_x":451,"top_left_y":1869,"width":808,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e48d4c035274527a498ecea9f24e8b0","type":"text","conversion_output":true,"text":"2. Demonstrate where you want the subject to walk.","text_display":"\n2. Demonstrate where you want the subject to walk.","confidence":1,"confidence_rate":1},{"cnt":[[451,1929],[1738,1929],[1738,1970],[451,1970]],"region":{"top_left_x":451,"top_left_y":1929,"width":1288,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02a32859b7cd490aa28f20ed7417b672","type":"text","conversion_output":true,"text":"3. Walk the subject to the start line (0 meters). Provide the subject with the following","text_display":"\n3. Walk the subject to the start line (0 meters). 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The start command is \"Ready and Go\".","text_display":" the floor.) The start command is \"Ready and Go\".","confidence":0.99951171875,"confidence_rate":0.9999907849387211},{"cnt":[[449,2131],[1777,2131],[1777,2172],[449,2172]],"region":{"top_left_x":449,"top_left_y":2131,"width":1328,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38aac2fd00c84703bf15a5973d9d2ccf","type":"text","conversion_output":true,"text":"4. When you and the subject are ready, say \"Ready and Go\". If the subject starts too","text_display":"\n4. When you and the subject are ready, say \"Ready and Go\". If the subject starts too","confidence":1,"confidence_rate":1},{"cnt":[[516,2179],[780,2179],[780,2215],[516,2215]],"region":{"top_left_x":515,"top_left_y":2178,"width":265,"height":38},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0d2e80282a94702b8bf3ea015cb5ee6","type":"text","conversion_output":true,"text":"early, start again.","text_display":" early, start again.","confidence":1,"confidence_rate":1},{"cnt":[[451,2393],[853,2393],[853,2430],[451,2430]],"region":{"top_left_x":451,"top_left_y":2393,"width":402,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cfc87ec21e948079af9c030d39e8996","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.989292820229366,"confidence_rate":0.9996412339018075},{"cnt":[[451,2428],[851,2428],[851,2462],[451,2462]],"region":{"top_left_x":451,"top_left_y":2427,"width":400,"height":36},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ffc8551b2e54b39b035050f5941a10a","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 1","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1745,2428],[1788,2428],[1788,2471],[1745,2471]],"region":{"top_left_x":1744,"top_left_y":2427,"width":44,"height":44},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c37adb952954dfe8f7421539aa16648","type":"page_info","conversion_output":false,"text":"88","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"edf9df0f471a4ce9b81de6c905b9426a","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9907512262278053,"confidence_rate":0.9998570593056708},{"cnt":[[372,2608],[692,2608],[692,2645],[372,2645]],"region":{"top_left_x":371,"top_left_y":2608,"width":321,"height":37},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc884980ed7b46a78c26f98d9b25d78c","type":"page_info","conversion_output":false,"text":"425/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-090","page":90,"lines":[{"cnt":[[911,344],[1321,344],[1321,436],[911,436]],"region":{"top_left_x":910,"top_left_y":343,"width":412,"height":94},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d881c5bee79f4a78867a29557df34b35","type":"section_header","conversion_output":false,"children_ids":["13a355219d3a49ff831c9d3e90430706","851e0ba10908476b8c83a311aca4ace9"],"text":"","text_display":""},{"cnt":[[915,348],[1317,348],[1317,397],[915,397]],"region":{"top_left_x":915,"top_left_y":348,"width":402,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13a355219d3a49ff831c9d3e90430706","type":"text","conversion_output":true,"parent_id":"d881c5bee79f4a78867a29557df34b35","text":"Appendix 12 (cont.)","text_display":"\n\n\\section*{Appendix 12 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[920,391],[1315,391],[1315,432],[920,432]],"region":{"top_left_x":919,"top_left_y":391,"width":396,"height":41},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"851e0ba10908476b8c83a311aca4ace9","type":"text","conversion_output":true,"parent_id":"d881c5bee79f4a78867a29557df34b35","text":"10 Meter Walk Test","text_display":" 10 Meter Walk Test}","confidence":0.99853515625,"confidence_rate":0.9999333695979722},{"cnt":[[451,498],[999,498],[999,539],[451,539]],"region":{"top_left_x":451,"top_left_y":498,"width":549,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b90a88c6a204d0e8e4c4b64a932b427","type":"text","conversion_output":true,"text":"5. Instructions for Recording Time:","text_display":"\n5. Instructions for Recording Time:","confidence":0.99951171875,"confidence_rate":0.9999877900620892},{"cnt":[[507,554],[1712,554],[1712,595],[507,595]],"region":{"top_left_x":507,"top_left_y":554,"width":1206,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d98aba9fb71d444f99e2a3f0ccb523d3","type":"text","conversion_output":true,"text":"□ START the stopwatch when the subject's first foot crosses the plane of the 2","text_display":"\n□ START the stopwatch when the subject's first foot crosses the plane of the 2","confidence":0.994631290435791,"confidence_rate":0.9999343537051192},{"cnt":[[563,597],[715,597],[715,634],[563,634]],"region":{"top_left_x":562,"top_left_y":597,"width":154,"height":37},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"278b91a058734760b1b57ffe013c74ef","type":"text","conversion_output":true,"text":"meter line","text_display":" meter line","confidence":1,"confidence_rate":1},{"cnt":[[507,657],[1708,657],[1708,698],[507,698]],"region":{"top_left_x":507,"top_left_y":657,"width":1202,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"621b741e3efc4caa9fee4ca0b572d82f","type":"text","conversion_output":true,"text":"□ STOP the stopwatch when the subject's first foot crosses the plane of the 12","text_display":"\n□ STOP the stopwatch when the subject's first foot crosses the plane of the 12","confidence":0.9931671619415283,"confidence_rate":0.9999163902176779},{"cnt":[[563,700],[724,700],[724,737],[563,737]],"region":{"top_left_x":562,"top_left_y":700,"width":163,"height":37},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"441d70953fb745ac8c5f677bb75fc5c9","type":"text","conversion_output":true,"text":"meter line.","text_display":" meter 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near the 14 meter line.","confidence":0.99267578125,"confidence_rate":0.9999069515124304},{"cnt":[[451,1096],[1764,1096],[1764,1137],[451,1137]],"region":{"top_left_x":451,"top_left_y":1095,"width":1313,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cea02daf9bc148cab4cc73bcdeb04e0c","type":"text","conversion_output":true,"text":"6. When the subject is ready, have them repeat the SAME PROCEDURE except they","text_display":"\n6. When the subject is ready, have them repeat the SAME PROCEDURE except they","confidence":1,"confidence_rate":1},{"cnt":[[516,1139],[1347,1139],[1347,1175],[516,1175]],"region":{"top_left_x":515,"top_left_y":1138,"width":833,"height":38},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53609c568e8f47358222a92a1f6cc11e","type":"text","conversion_output":true,"text":"will start from the 14 meter line and end at 0 meter line.","text_display":" will start from the 14 meter line and end at 0 meter line.","confidence":0.966796875,"confidence_rate":0.999510744905908},{"cnt":[[507,1199],[1729,1199],[1729,1240],[507,1240]],"region":{"top_left_x":507,"top_left_y":1198,"width":1223,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71a62f3cb69844598933abdd45975ec2","type":"text","conversion_output":true,"text":"□ START the stopwatch when the subject's first foot crosses the plane of the 12","text_display":"\n□ START the 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the","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[559,1543],[1749,1543],[1749,1583],[559,1583]],"region":{"top_left_x":558,"top_left_y":1542,"width":1191,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04b51e7bf1a64087a9721dc9f7ca74a7","type":"text","conversion_output":true,"text":"ten meter distance on the \"Comfortable\" Pace Trial 2 line on the 10 Meter Walk","text_display":" ten meter distance on the \"Comfortable\" Pace Trial 2 line on the 10 Meter Walk","confidence":1,"confidence_rate":1},{"cnt":[[561,1590],[922,1590],[922,1624],[561,1624]],"region":{"top_left_x":560,"top_left_y":1589,"width":362,"height":36},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65d83266c842447995d91a7038f140da","type":"text","conversion_output":true,"text":"Test Source Document.","text_display":" Test Source 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Subject Instructions for the last 2 trials:","text_display":"\n7. Subject Instructions for the last 2 trials:","confidence":0.9990234375,"confidence_rate":0.9999819068368716},{"cnt":[[518,1781],[1766,1781],[1766,1824],[518,1824]],"region":{"top_left_x":517,"top_left_y":1781,"width":1250,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e9ccb83077c45fab5b6800f8a003c66","type":"text","conversion_output":true,"text":"\"You are going to walk the same distances for two additional trials as quickly","text_display":"\n\"You are going to walk the same distances for two additional trials as quickly","confidence":1,"confidence_rate":1},{"cnt":[[516,1826],[1412,1826],[1412,1867],[516,1867]],"region":{"top_left_x":515,"top_left_y":1826,"width":897,"height":41},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88aac121455a4b37897bbd5d2c840fdf","type":"text","conversion_output":true,"text":"and as safely as you can. Do you have any questions?\"","text_display":" and as safely as you can. Do you have any questions?\"","confidence":0.9990234375,"confidence_rate":0.9999831546307154},{"cnt":[[451,1882],[1755,1882],[1755,1923],[451,1923]],"region":{"top_left_x":451,"top_left_y":1882,"width":1305,"height":41},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1785e09872b0451ab545fceb8a0fbb15","type":"text","conversion_output":true,"text":"8. When the subject is ready, walk the subject to the start line ( 0 meters). Provide the","text_display":"\n8. When the subject is ready, walk the subject to the start line ( 0 meters). 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When you and the subject are ready, say \"Ready and Go\". If the subject starts too","text_display":"\n9. When you and the subject are ready, say \"Ready and Go\". 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Instructions for Recording Time:","text_display":"\n10. 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\\multicolumn{5}{|c|}{HEMATOLOGY} \\\\\n\\hline ITEM & Grade 1 Toxicity & Grade 2 Toxicity & Grade 3 Toxicity & Grade 4 Toxicity \\\\\n\\hline Hemoglobin & \\(9.5-10.5 gm / Dl\\) & \\(8.0-9.4 gm / Dl\\) & \\(6.5-7.9 gm / Dl\\) & \\(<6.5 gm / Dl\\) \\\\\n\\hline Absolute Neutrophil Count & \\(1000-1500 / mm ^{3}\\) & \\(750-999 / mm ^{3}\\) & \\(500-749 / mm ^{3}\\) & \\(<500 / mm ^{3}\\) \\\\\n\\hline Platelets & \\(75000-99000 / mm ^{3}\\) & \\(50000-74999 / mm ^{3}\\) & \\(20000-49000 / mm ^{3}\\) & \\(<20000 / mm ^{3}\\) \\\\\n\\hline Prothrombin Time (PT) & \\(1.01-1.25 \\times\\) ULN & \\(1.26-1.5 \\times\\) ULN & 1.51-3.0× ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Activated Partial Thromboplastin (APPT) & 1.01-1.66x ULN & \\(1.67-2.33 \\times\\) ULN & 2.34-3 × ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Fibrinogen & 0.75-0.99XLLN & 0.50-0.74× LL.N & 0.25-0.49 x LLN & \\(<0.25 \\times\\) LLN \\\\\n\\hline Fibrim Split Product & \\(20-40 mcg / ml\\) & \\(41-50 mcg / ml\\) & \\(51-60 mcg / ml\\) & \\(>60 mcg / ml\\) \\\\\n\\hline Methemoglobin & 5-9.9\\% & 10.0-14.9\\% & 15.0-19.9\\% & \\(>20 \\%\\) \\\\\n\\hline \\multicolumn{5}{|c|}{LIVER ENZYMES} \\\\\n\\hline AST (SGOT) & \\(1.25-2.5 \\times\\) UL.N & 2.6 - 5 × ULN & 5.1-10x ULN & \\(>10 x\\) ULN \\\\\n\\hline ALT (SGPT) & \\(1.25-2.5 \\times\\) ULN & 2.6-5 × ULN & \\(5.1-10 x\\) ULN & \\(>10 \\times\\) ULN \\\\\n\\hline GGT & \\(1.25-2.5 \\times\\) ULN & 1.6-5 x ULN & \\(5.1-10 x\\) ULN & \\(>10 \\times ULN\\) \\\\\n\\hline Alkaline Phosphatase & 125-2.5x ULN & 16-5x ULN & \\(5.1-10 x\\) ULN & \\(>10 \\times\\) ULN \\\\\n\\hline Amylase & \\(1.1-1.5 \\times\\) ULN & \\(1.6-2.0 \\times\\) ULN & 2.1-5.0x ULN & \\(>5.1 \\times ULN\\) \\\\\n\\hline \\multicolumn{5}{|c|}{CHEMISTRIES} \\\\\n\\hline Hyponatremia & \\(130-135 mEq / L\\) & \\(123-129 mEq / L\\) & \\(116-122 mEq / L\\) & <116 or mental status changes or seizures \\\\\n\\hline Hypernatremia & \\(146-150 mEq / L\\) & \\(151-157 mEq / L\\) & \\(158-165 mEq / L\\). & \\(>165 mEq / L\\) or mental status changes or seizures \\\\\n\\hline Hypokalemia & \\(3.0-3.4 mEq / L\\) & \\(2.5 \\cdot 2.9 mEq / L\\) & \\(2.0-2.4 mEq / L\\) or intensive replacement Rx required or hospitalization required. & \\(<2.0 mEq / L\\) or paresis or ileus or life-threatening arrhythmua \\\\\n\\hline Hyperkalemia & \\(5.6-6.0 mEq / L\\) & \\(6.1-6.5 mEq / L\\) & \\(6.6-7.0 mEq / l\\) & \\(>7.0 mEq / L\\) or lifc-threatening arrhythmia \\\\\n\\hline Hypoglycemia & \\(55-64 mg / dL\\) & \\(40-54 mg / dL\\) & \\(30-39 mg / dL\\) & \\(<30 mg / dL\\) or mental status changes or coma \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multicolumn{5}{|c|}{HEMATOLOGY} \\\\\n\\hline ITEM & Grade 1 Toxicity & Grade 2 Toxicity & Grade 3 Toxicity & Grade 4 Toxicity \\\\\n\\hline Hemoglobin & \\(9.5-10.5 gm / Dl\\) & \\(8.0-9.4 gm / Dl\\) & \\(6.5-7.9 gm / Dl\\) & \\(<6.5 gm / Dl\\) \\\\\n\\hline Absolute Neutrophil Count & \\(1000-1500 / mm ^{3}\\) & \\(750-999 / mm ^{3}\\) & \\(500-749 / mm ^{3}\\) & \\(<500 / mm ^{3}\\) \\\\\n\\hline Platelets & \\(75000-99000 / mm ^{3}\\) & \\(50000-74999 / mm ^{3}\\) & \\(20000-49000 / mm ^{3}\\) & \\(<20000 / mm ^{3}\\) \\\\\n\\hline Prothrombin Time (PT) & \\(1.01-1.25 \\times\\) ULN & \\(1.26-1.5 \\times\\) ULN & 1.51-3.0× ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Activated Partial Thromboplastin (APPT) & 1.01-1.66x ULN & \\(1.67-2.33 \\times\\) ULN & 2.34-3 × ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Fibrinogen & 0.75-0.99XLLN & 0.50-0.74× LL.N & 0.25-0.49 x LLN & \\(<0.25 \\times\\) LLN \\\\\n\\hline Fibrim Split Product & \\(20-40 mcg / ml\\) & \\(41-50 mcg / ml\\) & \\(51-60 mcg / ml\\) & \\(>60 mcg / ml\\) \\\\\n\\hline Methemoglobin & 5-9.9\\% & 10.0-14.9\\% & 15.0-19.9\\% & \\(>20 \\%\\) \\\\\n\\hline \\multicolumn{5}{|c|}{LIVER ENZYMES} \\\\\n\\hline AST (SGOT) & \\(1.25-2.5 \\times\\) UL.N & 2.6 - 5 × ULN & 5.1-10x ULN & \\(>10 x\\) ULN \\\\\n\\hline ALT (SGPT) & \\(1.25-2.5 \\times\\) ULN & 2.6-5 × ULN & \\(5.1-10 x\\) ULN & \\(>10 \\times\\) ULN \\\\\n\\hline GGT & \\(1.25-2.5 \\times\\) ULN & 1.6-5 x ULN & \\(5.1-10 x\\) ULN & \\(>10 \\times ULN\\) \\\\\n\\hline Alkaline Phosphatase & 125-2.5x ULN & 16-5x ULN & \\(5.1-10 x\\) ULN & \\(>10 \\times\\) ULN \\\\\n\\hline Amylase & \\(1.1-1.5 \\times\\) ULN & \\(1.6-2.0 \\times\\) ULN & 2.1-5.0x ULN & \\(>5.1 \\times ULN\\) \\\\\n\\hline \\multicolumn{5}{|c|}{CHEMISTRIES} \\\\\n\\hline Hyponatremia & \\(130-135 mEq / L\\) & \\(123-129 mEq / L\\) & \\(116-122 mEq / L\\) & <116 or mental status changes or seizures \\\\\n\\hline Hypernatremia & \\(146-150 mEq / L\\) & \\(151-157 mEq / L\\) & \\(158-165 mEq / L\\). & \\(>165 mEq / L\\) or mental status changes or seizures \\\\\n\\hline Hypokalemia & \\(3.0-3.4 mEq / L\\) & \\(2.5 \\cdot 2.9 mEq / L\\) & \\(2.0-2.4 mEq / L\\) or intensive replacement Rx required or hospitalization required. & \\(<2.0 mEq / L\\) or paresis or ileus or life-threatening 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\\multicolumn{5}{|l|}{CHEMISTRIES (continued)} \\\\\n\\hline Hyperglycemis (note if fasting) & \\(116-160 mg / dL\\) & \\(161-250 mg / dL\\) & \\(251.500 mg / dL\\) & \\(>500 mg / dL\\) or ketoacidosis or seizures \\\\\n\\hline Hypocalcemia (corrected for albumin) & \\(8.4-7.8 mg / dL\\) & \\(7.7-7.0 mg / dL\\). & \\(6.9-6.1 mg / dL\\) & \\(<6.1 mg / dL\\) or life threatening arrhythmia or tetany \\\\\n\\hline Hypercalcemia (correct for albumin) & \\(10.6-11.5 mg / dL\\) & \\(11.6-12.5 mg / dL\\) & \\(12.6-13.5 mg / dL\\) & \\(>13.5 mg / dL\\) life-threatening arrhythmia \\\\\n\\hline Hypomagnesemia & \\(1.4-1.2 mEq / L\\) & \\(1.1-0.9 mEq / L\\) & \\(0.8-0.6 mEq / L\\) & \\(<0.6 mEq / L\\) or lifethreatening arrhythmia \\\\\n\\hline Hypophosphatemia & \\(2.0-2.4 mg / dL\\) & \\(1.5-1.9 mg / dL\\) or replacement Rx required & \\(1.0-1.4 mg / dL\\) intensive Rx or hospitalization required & \\(<1.0 mg / dL\\) or lifethreatening arrhythmia \\\\\n\\hline Hyperbilirubinemia & 1.1-1.5xULN & 1.6-2.5 x ULN & \\(2.6-5 x\\) ULN & >5xULN \\\\\n\\hline BUN & \\(1.25-2.5 \\times\\) ULN & \\(2.6-5 x\\) ULN & 5.1-10x ULN & \\(>10\\) xULN \\\\\n\\hline Creatinine & \\(1.1 \\times 1.5 \\times ULN\\) & 1.6-3.0xULN & 3.1-6 x ULN & >6xULNor required dialysis \\\\\n\\hline \\multicolumn{5}{|c|}{URINALYSIS} \\\\\n\\hline Proteinuria & 1+ or \\(<0.3 \\%\\) or \\(<3 g / L\\) or \\(200 mg -1 gm\\) loss/day & 2-3 + or 0.3-1.0\\% or \\(3-10 g / L\\) 1.2 gm loss/day & \\(4+\\) or \\(>1.0 \\%\\) or \\(>10\\) g/L. \\(2-3.5 gm\\) loss/day & nephrotic syndrome or \\(\\gg 3,5 gm\\) loss/day \\\\\n\\hline Hematuria & microscopic only & gross, no clots & gross* clots & obstructive or required transsusion \\\\\n\\hline \\multicolumn{5}{|l|}{CARDIAC DYSFUNCTION} \\\\\n\\hline Cardiac Rhythm & & asymptomatic, transient signs, no Rx required & recurrent/persistent; No Rx required & requires treatment \\\\\n\\hline Hypertension & transient inc. \\(>20 mm\\); no Rx & recurrent, chronic, > 20 mm . 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New ICH seen on imaging will be later confirmed on independent","text_display":" the investigator. New ICH seen on imaging will be later confirmed on independent","confidence":1,"confidence_rate":1},{"cnt":[[546,971],[1175,971],[1175,1008],[546,1008]],"region":{"top_left_x":545,"top_left_y":971,"width":631,"height":37},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4b9f3211a254f138fc85254fcacfd1c","type":"text","conversion_output":true,"text":"reading by blinded central study radiologists.","text_display":" reading by blinded central study radiologists.","confidence":1,"confidence_rate":1},{"cnt":[[447,1014],[846,1014],[846,1055],[447,1055]],"region":{"top_left_x":446,"top_left_y":1014,"width":401,"height":41},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96432a00b23d4bfcb4a86a9491b34e31","type":"text","conversion_output":true,"text":"- Any ICH within 36 hours","text_display":"\n- Any ICH within 36 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The placebo will be identical in appearance to active aspirin to","text_display":" time they receive IV alteplase. 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The primary efficacy outcome is the","text_display":" standard medical care in AIS patients with mild deficits. 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For example, the proportion of mild stroke patients (NIHSS \\(\\leq 3\\) )","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[432,1506],[1742,1506],[1742,1549],[432,1549]],"region":{"top_left_x":431,"top_left_y":1506,"width":1312,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99e3b5c6723a41519602e6d700f0f389","type":"text","conversion_output":true,"text":"treated with reperfusion therapies at National Institutes of Health/National Institute of","text_display":" treated with reperfusion therapies at National Institutes of Health/National Institute of","confidence":0.94482421875,"confidence_rate":0.9993963909612812},{"cnt":[[434,1555],[1708,1555],[1708,1596],[434,1596]],"region":{"top_left_x":433,"top_left_y":1555,"width":1276,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a27a4d6654b4404ab46d7d032510242f","type":"text","conversion_output":true,"text":"Neurological Disorders and Stroke (NINDS) Specialized Programs of Translational","text_display":" Neurological Disorders and Stroke (NINDS) Specialized Programs of Translational","confidence":1,"confidence_rate":1},{"cnt":[[434,1603],[1755,1603],[1755,1644],[434,1644]],"region":{"top_left_x":433,"top_left_y":1602,"width":1323,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b394d640cc741bbae2364dd497d3eff","type":"text","conversion_output":true,"text":"Research in Acute Stroke (SPOTRIAS) centers ranged from 2\\%-16\\% in 2008-2009","text_display":" Research in Acute Stroke (SPOTRIAS) centers ranged from 2\\%-16\\% in 2008-2009","confidence":0.3867834492440827,"confidence_rate":0.9881965845445467},{"cnt":[[434,1650],[1721,1650],[1721,1691],[434,1691]],"region":{"top_left_x":433,"top_left_y":1650,"width":1288,"height":41},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1749c681d63b48c1b8a754def5ea462e","type":"text","conversion_output":true,"text":"(Wiley et al. 2012). This variability in approach is also evident upon discussion with","text_display":" (Wiley et al. 2012). This variability in approach is also evident upon discussion with","confidence":1,"confidence_rate":1},{"cnt":[[432,1697],[1695,1697],[1695,1738],[432,1738]],"region":{"top_left_x":431,"top_left_y":1697,"width":1265,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48496fdd930f4aed9a246f3a7a9aae0b","type":"text","conversion_output":true,"text":"former leaders of the pivotal NINDS trials; some physicians treat all eligible stroke","text_display":" former leaders of the pivotal NINDS trials; some physicians treat all eligible stroke","confidence":1,"confidence_rate":1},{"cnt":[[434,1745],[1571,1745],[1571,1785],[434,1785]],"region":{"top_left_x":433,"top_left_y":1744,"width":1138,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10518512b07f461283d39fb06b6b4e1d","type":"text","conversion_output":true,"text":"patients regardless of severity, and others treat only a minority of patients","text_display":" patients regardless of severity, and others treat only a minority of patients","confidence":1,"confidence_rate":1},{"cnt":[[434,1790],[677,1790],[677,1837],[434,1837]],"region":{"top_left_x":433,"top_left_y":1789,"width":244,"height":48},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14d48ea6cd214d1880a48dac39f0fa9c","type":"form_field","conversion_output":true,"text":"","text_display":"\n□","subtype":"box"},{"cnt":[[675,1792],[1665,1792],[1665,1833],[675,1833]],"region":{"top_left_x":674,"top_left_y":1791,"width":992,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea76fa7172204963bdfc06d2f3371da1","type":"text","conversion_output":true,"text":", personal communication). There is unquestionable community","text_display":" , personal communication). There is unquestionable community","confidence":1,"confidence_rate":1},{"cnt":[[434,1839],[1515,1839],[1515,1880],[434,1880]],"region":{"top_left_x":433,"top_left_y":1839,"width":1082,"height":41},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28c365d2cbd743bd8e56181ae886cffe","type":"text","conversion_output":true,"text":"equipoise regarding the acute treatment of the mild stroke population.","text_display":" equipoise regarding the acute treatment of the mild stroke population.","confidence":1,"confidence_rate":1},{"cnt":[[432,1914],[1246,1914],[1246,1957],[432,1957]],"region":{"top_left_x":431,"top_left_y":1914,"width":816,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08839c4ad8ab4ded9be8b9575b83bb8f","type":"section_header","conversion_output":false,"children_ids":["db1e53076d9e4e23ae9637626538eaf4"],"text":"","text_display":""},{"cnt":[[434,1916],[1244,1916],[1244,1953],[434,1953]],"region":{"top_left_x":433,"top_left_y":1916,"width":811,"height":37},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db1e53076d9e4e23ae9637626538eaf4","type":"text","conversion_output":true,"parent_id":"08839c4ad8ab4ded9be8b9575b83bb8f","text":"1.2 BACKGROUND ON ALTEPLASE","text_display":"\n\n\\subsection*{1.2 BACKGROUND ON ALTEPLASE}","confidence":0.99609375,"confidence_rate":0.9998776981256986},{"cnt":[[432,1972],[1510,1972],[1510,2022],[432,2022]],"region":{"top_left_x":431,"top_left_y":1972,"width":1080,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f17cc491ec6c436b81c1496e7b24ef96","type":"section_header","conversion_output":false,"children_ids":["9f8df4b93b4941599674221e87b4155d"],"text":"","text_display":""},{"cnt":[[434,1977],[1508,1977],[1508,2022],[434,2022]],"region":{"top_left_x":433,"top_left_y":1976,"width":1076,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f8df4b93b4941599674221e87b4155d","type":"text","conversion_output":true,"parent_id":"f17cc491ec6c436b81c1496e7b24ef96","text":"1.2.1 Fibrinolysis and Tissue Plasminogen Activator","text_display":"\n\n\\subsection*{1.2.1 Fibrinolysis and Tissue Plasminogen Activator}","confidence":1,"confidence_rate":1},{"cnt":[[434,2037],[1717,2037],[1717,2078],[434,2078]],"region":{"top_left_x":433,"top_left_y":2036,"width":1284,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acecd6d1576e45f2bdfcd7d737f0c0c4","type":"text","conversion_output":true,"text":"Physiologic dissolution of a thrombus depends primarily on the proteolytic action of","text_display":"\n\nPhysiologic dissolution of a thrombus depends primarily on the proteolytic action of","confidence":1,"confidence_rate":1},{"cnt":[[434,2084],[1803,2084],[1803,2125],[434,2125]],"region":{"top_left_x":433,"top_left_y":2083,"width":1370,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"651c2068773348d8a9f1fc9b3287864d","type":"text","conversion_output":true,"text":"plasmin formed from plasminogen at the site of a clot. The mechanism for this activation","text_display":" plasmin formed from plasminogen at the site of a clot. The mechanism for this activation","confidence":1,"confidence_rate":1},{"cnt":[[434,2131],[1755,2131],[1755,2172],[434,2172]],"region":{"top_left_x":433,"top_left_y":2131,"width":1323,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee7866215ca94f0f937bb7ac240f9c94","type":"text","conversion_output":true,"text":"in vivo has not been definitively established. Plasminogen, the zymogen precursor of","text_display":" in vivo has not been definitively established. 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The","text_display":" plasminogen activator [t-PA]), in urine (urokinase), and in bacteria (streptokinase). 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suggest that plasminogen activation in the presence of fibrin","confidence":1,"confidence_rate":1},{"cnt":[[430,391],[1796,391],[1796,436],[430,436]],"region":{"top_left_x":429,"top_left_y":391,"width":1368,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6110b2030294cb0b8dca1b3eeaf6d45","type":"text","conversion_output":true,"text":"occurs after the binding of plasminogen and t-PA at the clot site. t-PA has a high affinity","text_display":" occurs after the binding of plasminogen and t-PA at the clot site. t-PA has a high affinity","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[430,438],[1777,438],[1777,483],[430,483]],"region":{"top_left_x":429,"top_left_y":438,"width":1348,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96443edc13864d48b1390777afae5a36","type":"text","conversion_output":true,"text":"for fibrin, thereby efficiently activating the fibrin-bound plasminogen and converting it to","text_display":" for fibrin, thereby efficiently activating the fibrin-bound plasminogen and converting it to","confidence":0.99072265625,"confidence_rate":0.9999039154789536},{"cnt":[[430,486],[1732,486],[1732,531],[430,531]],"region":{"top_left_x":429,"top_left_y":485,"width":1303,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f59e7dd2317d431ebf210fb8e1105c49","type":"text","conversion_output":true,"text":"plasmin. Plasmin, which when bound to fibrin is protected from rapid inactivation by","text_display":" plasmin. Plasmin, which when bound to fibrin is protected from rapid inactivation by","confidence":1,"confidence_rate":1},{"cnt":[[430,533],[1265,533],[1265,578],[430,578]],"region":{"top_left_x":429,"top_left_y":532,"width":837,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9525c3bd01dd42a996d5c8e53cdf5377","type":"text","conversion_output":true,"text":"\\(\\alpha 2\\)-antiplasmin, then proceeds to digest the fibrin clot.","text_display":" \\(\\alpha 2\\)-antiplasmin, then proceeds to digest the fibrin clot.","confidence":0.99853515625,"confidence_rate":0.9999759688513347},{"cnt":[[430,619],[1693,619],[1693,666],[430,666]],"region":{"top_left_x":429,"top_left_y":618,"width":1264,"height":49},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e101ddc572b247a88038927404ce7feb","type":"text","conversion_output":true,"text":"See the Activase \\({ }^{\\text {® }}\\) (alteplase) U.S. Package Insert (USPI) for additional details on","text_display":"\n\nSee the Activase \\({ }^{\\text {® }}\\) (alteplase) U.S. Package Insert (USPI) for additional details on","confidence":0.99267578125,"confidence_rate":0.9999286319397236},{"cnt":[[430,670],[913,670],[913,709],[430,709]],"region":{"top_left_x":429,"top_left_y":670,"width":485,"height":39},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2de5d6de93e49ae982d6511770ea845","type":"text","conversion_output":true,"text":"nonclinical and clinical studies.","text_display":" nonclinical and clinical studies.","confidence":1,"confidence_rate":1},{"cnt":[[430,741],[1671,741],[1671,793],[430,793]],"region":{"top_left_x":429,"top_left_y":741,"width":1243,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9e0df83fea844e9aeb5fb287637cf92","type":"section_header","conversion_output":false,"children_ids":["8a249c61b6c4457cabe4e993a05f8525"],"text":"","text_display":""},{"cnt":[[434,748],[1665,748],[1665,788],[434,788]],"region":{"top_left_x":433,"top_left_y":747,"width":1233,"height":42},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a249c61b6c4457cabe4e993a05f8525","type":"text","conversion_output":true,"parent_id":"e9e0df83fea844e9aeb5fb287637cf92","text":"1.3 STUDY RATIONALE AND BENEFIT-RISK ASSESSMENT","text_display":"\n\n\\subsection*{1.3 STUDY RATIONALE AND BENEFIT-RISK ASSESSMENT}","confidence":0.99609375,"confidence_rate":0.9999247355378745},{"cnt":[[430,812],[1764,812],[1764,857],[430,857]],"region":{"top_left_x":429,"top_left_y":812,"width":1335,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec87694a4c774f86a5d2a08eb1aba870","type":"text","conversion_output":true,"text":"Alteplase is the only approved therapeutic agent for the treatment of AIS and is widely","text_display":"\n\nAlteplase is the only approved therapeutic agent for the treatment of AIS and is widely","confidence":1,"confidence_rate":1},{"cnt":[[430,862],[1732,862],[1732,904],[430,904]],"region":{"top_left_x":429,"top_left_y":861,"width":1303,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22e75faab35845059711a54daacc7cf7","type":"text","conversion_output":true,"text":"accepted as the standard of care for eligible patients (Edlow et al. 2013; Jauch et al.","text_display":" accepted as the standard of care for eligible patients (Edlow et al. 2013; Jauch et al.","confidence":0.9990234375,"confidence_rate":0.9999893800602199},{"cnt":[[430,907],[1708,907],[1708,952],[430,952]],"region":{"top_left_x":429,"top_left_y":906,"width":1280,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6efb588dcd045d29010c7b4d9865cda","type":"text","conversion_output":true,"text":"2013). The currently approved alteplase USPI contains wording that recommends","text_display":" 2013). The currently approved alteplase USPI contains wording that recommends","confidence":1,"confidence_rate":1},{"cnt":[[430,956],[1678,956],[1678,1001],[430,1001]],"region":{"top_left_x":429,"top_left_y":956,"width":1249,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d98d3e22bf084a95a39f7031f131a8b8","type":"text","conversion_output":true,"text":"against use of alteplase in patients with \"minor neurological deficit or with rapidly","text_display":" against use of alteplase in patients with \"minor neurological deficit or with rapidly","confidence":1,"confidence_rate":1},{"cnt":[[430,1001],[1665,1001],[1665,1046],[430,1046]],"region":{"top_left_x":429,"top_left_y":1001,"width":1237,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71247d0dc21e4f539fbf5d1d3ffff686","type":"text","conversion_output":true,"text":"improving stroke symptoms\" due to the fact this patient population has not been","text_display":" improving stroke symptoms\" due to the fact this patient population has not been","confidence":1,"confidence_rate":1},{"cnt":[[430,1051],[1704,1051],[1704,1094],[430,1094]],"region":{"top_left_x":429,"top_left_y":1050,"width":1275,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4ae29fa99244681a8a93e18c41381f8","type":"text","conversion_output":true,"text":"evaluated. Furthermore, the current American Heart Association/American Stroke","text_display":" evaluated. Furthermore, the current American Heart Association/American Stroke","confidence":1,"confidence_rate":1},{"cnt":[[430,1096],[1760,1096],[1760,1143],[430,1143]],"region":{"top_left_x":429,"top_left_y":1095,"width":1331,"height":48},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da390c5a50d44de68b0ad9ef509c97d4","type":"text","conversion_output":true,"text":"Association Council Guidelines include \"minor and rapidly improving stroke symptoms","text_display":" Association Council Guidelines include \"minor and rapidly improving stroke symptoms","confidence":0.998046875,"confidence_rate":0.9999777839418279},{"cnt":[[432,1145],[1717,1145],[1717,1192],[432,1192]],"region":{"top_left_x":431,"top_left_y":1145,"width":1286,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fac34f3ba8445dba07b4611ede9cc35","type":"text","conversion_output":true,"text":"(clearing spontaneously)\" as a relative exclusion criterion for alteplase (Jauch, et al.","text_display":" (clearing spontaneously)\" as a relative exclusion criterion for alteplase (Jauch, et al.","confidence":1,"confidence_rate":1},{"cnt":[[430,1195],[1699,1195],[1699,1240],[430,1240]],"region":{"top_left_x":429,"top_left_y":1194,"width":1271,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"508ec0d12fa04455b9d84f3fd327836b","type":"text","conversion_output":true,"text":"2013). This is largely due to the aforementioned label wording not recommending","text_display":" 2013). This is largely due to the aforementioned label wording not recommending","confidence":0.99853515625,"confidence_rate":0.9999825487512927},{"cnt":[[430,1242],[1712,1242],[1712,1285],[430,1285]],"region":{"top_left_x":429,"top_left_y":1241,"width":1284,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"381dd4614ebd48b989a2b36ea9fbf105","type":"text","conversion_output":true,"text":"treatment of patients with minor neurological deficit or with rapidly improving stroke","text_display":" treatment of patients with minor neurological deficit or with rapidly improving stroke","confidence":1,"confidence_rate":1},{"cnt":[[430,1289],[1777,1289],[1777,1334],[430,1334]],"region":{"top_left_x":429,"top_left_y":1289,"width":1348,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b67beca5fda41a8b493b35aa86a8a86","type":"text","conversion_output":true,"text":"symptoms (RISS), the lack of a consistent and consensus definition on who constitutes","text_display":" symptoms (RISS), the lack of a consistent and consensus definition on who constitutes","confidence":1,"confidence_rate":1},{"cnt":[[430,1336],[1807,1336],[1807,1381],[430,1381]],"region":{"top_left_x":429,"top_left_y":1336,"width":1378,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e3ee1ed3c4e44ac94b2dcddc2a0ef86","type":"text","conversion_output":true,"text":"this patient population, and the absence of definitive evidence of alteplase efficacy in this","text_display":" this patient population, and the absence of definitive evidence of alteplase efficacy in this","confidence":1,"confidence_rate":1},{"cnt":[[430,1381],[1790,1381],[1790,1429],[430,1429]],"region":{"top_left_x":429,"top_left_y":1381,"width":1361,"height":48},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"420c03217ab145c7b0841f3be9108620","type":"text","conversion_output":true,"text":"setting (Levine et al. 2013). Therefore, this trial is designed to evaluate the efficacy and","text_display":" setting (Levine et al. 2013). Therefore, this trial is designed to evaluate the efficacy and","confidence":1,"confidence_rate":1},{"cnt":[[430,1431],[1794,1431],[1794,1476],[430,1476]],"region":{"top_left_x":429,"top_left_y":1430,"width":1365,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bbd40b97867479ba467d1e2b65e22d4","type":"text","conversion_output":true,"text":"safety of alteplase in confirmed AIS patients with minor neurological deficit or with RISS,","text_display":" safety of alteplase in confirmed AIS patients with minor neurological deficit or with RISS,","confidence":1,"confidence_rate":1},{"cnt":[[430,1478],[1609,1478],[1609,1523],[430,1523]],"region":{"top_left_x":429,"top_left_y":1478,"width":1181,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d7f169718264f949e69ee43ad6b6b12","type":"text","conversion_output":true,"text":"which will be referred to collectively as \"mild stroke\" throughout the protocol.","text_display":" which will be referred to collectively as \"mild stroke\" throughout the protocol.","confidence":1,"confidence_rate":1},{"cnt":[[430,1566],[1790,1566],[1790,1609],[430,1609]],"region":{"top_left_x":429,"top_left_y":1566,"width":1361,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6687da08be664c9b87975d642f9b7e3a","type":"text","conversion_output":true,"text":"To date, all completed major randomized acute stroke trials have excluded patients with","text_display":"\n\nTo date, all completed major randomized acute stroke trials have excluded patients with","confidence":1,"confidence_rate":1},{"cnt":[[432,1611],[1764,1611],[1764,1656],[432,1656]],"region":{"top_left_x":431,"top_left_y":1611,"width":1333,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16dfbb121a8d4a7e8ea60476d877974e","type":"text","conversion_output":true,"text":"mild strokes to varying degrees. In the two NINDS trials, such patients were excluded","text_display":" mild strokes to varying degrees. In the two NINDS trials, such patients were excluded","confidence":1,"confidence_rate":1},{"cnt":[[432,1661],[1800,1661],[1800,1706],[432,1706]],"region":{"top_left_x":431,"top_left_y":1660,"width":1370,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f72d70da80b4caba3f5cf1c1cc0b735","type":"text","conversion_output":true,"text":"according to the protocol (largely to prevent patients with transient ischemic attacks from","text_display":" according to the protocol (largely to prevent patients with transient ischemic attacks from","confidence":1,"confidence_rate":1},{"cnt":[[430,1708],[1764,1708],[1764,1751],[430,1751]],"region":{"top_left_x":429,"top_left_y":1708,"width":1335,"height":43},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1ba99cd83a8428083e995dbd0f9ba26","type":"text","conversion_output":true,"text":"being enrolled if they were having rapidly improving symptoms), but did not include an","text_display":" being enrolled if they were having rapidly improving symptoms), but did not include an","confidence":1,"confidence_rate":1},{"cnt":[[430,1755],[1772,1755],[1772,1798],[430,1798]],"region":{"top_left_x":429,"top_left_y":1755,"width":1344,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef329eff34804649ae70cacc75244c9e","type":"text","conversion_output":true,"text":"explicit definition of mild stroke except for pure sensory stroke, isolated ataxia, isolated","text_display":" explicit definition of mild stroke except for pure sensory stroke, isolated ataxia, isolated","confidence":1,"confidence_rate":1},{"cnt":[[430,1805],[1669,1805],[1669,1850],[430,1850]],"region":{"top_left_x":429,"top_left_y":1804,"width":1241,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2626026101b4445b9c8fc3cd8c2d0a52","type":"text","conversion_output":true,"text":"dysarthria, and isolated facial weakness (NINDS rt-PA Study Group 1995). The","text_display":" dysarthria, and isolated facial weakness (NINDS rt-PA Study Group 1995). The","confidence":1,"confidence_rate":1},{"cnt":[[430,1852],[1755,1852],[1755,1897],[430,1897]],"region":{"top_left_x":429,"top_left_y":1851,"width":1327,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c120d43a6c54ba0adb2d5041d825744","type":"text","conversion_output":true,"text":"operational definition for stroke symptoms too mild to treat was left to the judgment of","text_display":" operational definition for stroke symptoms too mild to treat was left to the judgment of","confidence":1,"confidence_rate":1},{"cnt":[[430,1897],[1783,1897],[1783,1944],[430,1944]],"region":{"top_left_x":429,"top_left_y":1897,"width":1355,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"613b0f8929684574bf4a255aba5a4bde","type":"text","conversion_output":true,"text":"the randomizing physician (Levine et al. 2013). Interestingly, a post hoc analysis of the","text_display":" the randomizing physician (Levine et al. 2013). Interestingly, a post hoc analysis of the","confidence":1,"confidence_rate":1},{"cnt":[[430,1946],[1764,1946],[1764,1992],[430,1992]],"region":{"top_left_x":429,"top_left_y":1946,"width":1335,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfe2442be50942afa17149a35207fd08","type":"text","conversion_output":true,"text":"624 patients in the NINDS trial revealed that there were 58 patients ( \\(9 \\%\\) ) enrolled with","text_display":" 624 patients in the NINDS trial revealed that there were 58 patients ( \\(9 \\%\\) ) enrolled with","confidence":0.99072265625,"confidence_rate":0.999905856489015},{"cnt":[[430,1994],[1779,1994],[1779,2039],[430,2039]],"region":{"top_left_x":429,"top_left_y":1993,"width":1350,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd0294a5dff243638ff114ead79af9f5","type":"text","conversion_output":true,"text":"an NIHSS score \\(\\leq 5\\), none of whom had isolated motor symptoms, isolated facial droop,","text_display":" an NIHSS score \\(\\leq 5\\), none of whom had isolated motor symptoms, isolated facial droop,","confidence":0.9975595474243164,"confidence_rate":0.9999734412729728},{"cnt":[[430,2041],[1729,2041],[1729,2086],[430,2086]],"region":{"top_left_x":429,"top_left_y":2041,"width":1301,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc191270a79d44eba93ad31ae507029a","type":"text","conversion_output":true,"text":"isolated ataxia, dysarthria, isolated sensory, and three or fewer of each of additional","text_display":" isolated ataxia, dysarthria, isolated sensory, and three or fewer of each of additional","confidence":1,"confidence_rate":1},{"cnt":[[430,2088],[1725,2088],[1725,2133],[430,2133]],"region":{"top_left_x":429,"top_left_y":2088,"width":1297,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f222f32c89ec4db78bca02b206ef77a9","type":"text","conversion_output":true,"text":"isolated deficits (Khatri et al. 2010). Perhaps more significantly, 2971 patients were","text_display":" isolated deficits (Khatri et al. 2010). Perhaps more significantly, 2971 patients were","confidence":1,"confidence_rate":1},{"cnt":[[432,2136],[1656,2136],[1656,2181],[432,2181]],"region":{"top_left_x":431,"top_left_y":2135,"width":1226,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e618475f852407fbb8588860ebdcadf","type":"text","conversion_output":true,"text":"excluded primarily due to \"rapidly improving\" or \"minor symptoms.\" However, a","text_display":" excluded primarily due to \"rapidly improving\" or \"minor symptoms.\" However, a","confidence":1,"confidence_rate":1},{"cnt":[[432,2183],[1764,2183],[1764,2228],[432,2228]],"region":{"top_left_x":431,"top_left_y":2182,"width":1333,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dddb673bbed841dfb1ead080a423b00a","type":"text","conversion_output":true,"text":"significant unmet medical need exists for patients with mild stroke. Available outcome","text_display":" significant unmet medical need exists for patients with mild stroke. Available outcome","confidence":1,"confidence_rate":1},{"cnt":[[430,2230],[1785,2230],[1785,2275],[430,2275]],"region":{"top_left_x":429,"top_left_y":2230,"width":1357,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"741928af82f24aceb012876914627adb","type":"text","conversion_output":true,"text":"data for patients with mild stroke who do not receive alteplase consistently demonstrate","text_display":" data for patients with mild stroke who do not receive alteplase consistently demonstrate","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[430,2277],[1790,2277],[1790,2322],[430,2322]],"region":{"top_left_x":429,"top_left_y":2277,"width":1361,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89e0180dfeb345e297a8f3577145d8c4","type":"text","conversion_output":true,"text":"a high rate of suboptimal outcomes. Specifically, in two different prospective databases","text_display":" a high rate of suboptimal outcomes. Specifically, in two different prospective databases","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[430,2325],[1783,2325],[1783,2370],[430,2370]],"region":{"top_left_x":429,"top_left_y":2324,"width":1355,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ab69dce1b7e4f899bcf2e5fd85834d9","type":"text","conversion_output":true,"text":"of patients with mild deficits (NIHSS score \\(\\leq 5\\) ) and no baseline disability, approximately","text_display":" of patients with mild deficits (NIHSS score \\(\\leq 5\\) ) and no baseline disability, approximately","confidence":0.9980475902557373,"confidence_rate":0.9999800581765897},{"cnt":[[425,2419],[849,2419],[849,2464],[425,2464]],"region":{"top_left_x":425,"top_left_y":2419,"width":424,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"069e6c42641a476b8aa8507c3e053e80","type":"section_header","conversion_output":false,"children_ids":["177f66621580455585636366a35947f5"],"text":"","text_display":""},{"cnt":[[430,2423],[844,2423],[844,2460],[430,2460]],"region":{"top_left_x":429,"top_left_y":2423,"width":416,"height":37},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"177f66621580455585636366a35947f5","type":"text","conversion_output":true,"parent_id":"069e6c42641a476b8aa8507c3e053e80","text":"Alteplase-Genentech, Inc.","text_display":"\n\n\\section*{Alteplase-Genentech, Inc.}","confidence":0.9951240979141858,"confidence_rate":0.9998370856693533},{"cnt":[[432,2460],[849,2460],[849,2499],[432,2499]],"region":{"top_left_x":431,"top_left_y":2459,"width":418,"height":40},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36ab8ce96af04b74b6ca12ae97944342","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1766,2462],[1818,2462],[1818,2505],[1766,2505]],"region":{"top_left_x":1766,"top_left_y":2462,"width":52,"height":44},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02c68ddfcf774ba8a257b772041a9452","type":"page_info","conversion_output":false,"text":"30","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41d33caf2c244d448b7aeb20307e3f19","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9931781182558552,"confidence_rate":0.9998946938966221},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a57c9b67e224dddbe1356affa2dbad8","type":"page_info","conversion_output":false,"text":"462/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-127","page":127,"lines":[{"cnt":[[430,344],[1717,344],[1717,389],[430,389]],"region":{"top_left_x":429,"top_left_y":343,"width":1288,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"feb20f3d5372426fa8e4174494158445","type":"text","conversion_output":true,"text":"one-third \\((29 \\%-32 \\%)\\) were significantly disabled (as measured by modified Rankin","text_display":"\none-third \\((29 \\%-32 \\%)\\) were significantly disabled (as measured by modified Rankin","confidence":0.6306018829345703,"confidence_rate":0.994714242647986},{"cnt":[[430,391],[1588,391],[1588,436],[430,436]],"region":{"top_left_x":429,"top_left_y":391,"width":1159,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f3588cb52b243b79c4b3b6fcdd6b03b","type":"text","conversion_output":true,"text":"Scale [mRS] score 2-6) at 90 days (Fischer et al. 2010; Khatri et al. 2012;","text_display":" Scale [mRS] score 2-6) at 90 days (Fischer et al. 2010; Khatri et al. 2012;","confidence":0.9956090442137793,"confidence_rate":0.9999469818350816},{"cnt":[[425,438],[664,438],[664,492],[425,492]],"region":{"top_left_x":425,"top_left_y":438,"width":239,"height":54},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8fcc80738ee4fc389d8b08a16a99fc4","type":"form_field","conversion_output":true,"text":"","text_display":"\n□","subtype":"box"},{"cnt":[[662,438],[1085,438],[1085,488],[662,488]],"region":{"top_left_x":661,"top_left_y":438,"width":424,"height":50},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d44cfd39a22d42c69436595e26f0fd65","type":"text","conversion_output":true,"text":", personal communication).","text_display":" , personal communication).","confidence":1,"confidence_rate":1},{"cnt":[[432,526],[1755,526],[1755,569],[432,569]],"region":{"top_left_x":431,"top_left_y":526,"width":1325,"height":44},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32a457e649474b74bcc6ef4e56dd0d22","type":"text","conversion_output":true,"text":"Existing, albeit limited, data suggest that the potential benefit-risk ratio for alteplase in","text_display":"\n\nExisting, albeit limited, data suggest that the potential benefit-risk ratio for alteplase in","confidence":1,"confidence_rate":1},{"cnt":[[430,576],[1665,576],[1665,614],[430,614]],"region":{"top_left_x":429,"top_left_y":575,"width":1237,"height":40},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0df4c7abac75452bae254745184d4f56","type":"text","conversion_output":true,"text":"mild stroke should be favorable. Gonzales et al. demonstrated better functional","text_display":" mild stroke should be favorable. Gonzales et al. demonstrated better functional","confidence":1,"confidence_rate":1},{"cnt":[[430,623],[1794,623],[1794,664],[430,664]],"region":{"top_left_x":429,"top_left_y":623,"width":1365,"height":41},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee7e41d0beac427ba1ea32f419bbb5be","type":"text","conversion_output":true,"text":"outcomes among mild strokes treated with IV alteplase compared to those not treated in","text_display":" outcomes among mild strokes treated with IV alteplase compared to those not treated in","confidence":1,"confidence_rate":1},{"cnt":[[430,670],[1790,670],[1790,711],[430,711]],"region":{"top_left_x":429,"top_left_y":670,"width":1361,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f81a917148834402a57c7bdf05bc0a52","type":"text","conversion_output":true,"text":"a large, single-center, retrospective cohort; this was shown with two different thresholds","text_display":" a large, single-center, retrospective cohort; this was shown with two different thresholds","confidence":1,"confidence_rate":1},{"cnt":[[430,718],[1721,718],[1721,763],[430,763]],"region":{"top_left_x":429,"top_left_y":717,"width":1292,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20602d0542e14247a61ee91fe03a6993","type":"text","conversion_output":true,"text":"of stroke severity (NIHSS \\(\\leq 7\\) and NIHSS \\(\\leq 3\\) ) (Gonzales et al. 2006). Additionally, a","text_display":" of stroke severity (NIHSS \\(\\leq 7\\) and NIHSS \\(\\leq 3\\) ) (Gonzales et al. 2006). 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For PRISMS, the primary efficacy outcome assumption (mRS \\(0-1\\) ) is","text_display":" communication). For PRISMS, the primary efficacy outcome assumption (mRS \\(0-1\\) ) is","confidence":0.612539529800415,"confidence_rate":0.9945079256495584},{"cnt":[[430,954],[1710,954],[1710,999],[430,999]],"region":{"top_left_x":429,"top_left_y":953,"width":1282,"height":47},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67c4871af408447cb0cfe44b2e74941a","type":"text","conversion_output":true,"text":"a \\(9 \\%\\) absolute treatment effect of alteplase relative to placebo. This assumption is","text_display":" a \\(9 \\%\\) absolute treatment effect of alteplase relative to placebo. This assumption is","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[430,1001],[1777,1001],[1777,1046],[430,1046]],"region":{"top_left_x":429,"top_left_y":1001,"width":1348,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e718a914be5e4138a13ead389c80f0ba","type":"text","conversion_output":true,"text":"based on several retrospective analyses of similar patient populations (Köhrmann et al.","text_display":" based on several retrospective analyses of similar patient populations (Köhrmann et al.","confidence":1,"confidence_rate":1},{"cnt":[[430,1048],[1665,1048],[1665,1094],[430,1094]],"region":{"top_left_x":429,"top_left_y":1048,"width":1237,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfe2b40e075f45dbb22ae9a769bcdc58","type":"text","conversion_output":true,"text":"2009; Fischer el al. 2010; Hassan et al. 2010b; Khatri et al. 2012) as well as the","text_display":" 2009; Fischer el al. 2010; Hassan et al. 2010b; Khatri et al. 2012) as well as the","confidence":1,"confidence_rate":1},{"cnt":[[430,1096],[1137,1096],[1137,1141],[430,1141]],"region":{"top_left_x":429,"top_left_y":1095,"width":708,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cab2efc426e344bcb56281ae7d344c1e","type":"text","conversion_output":true,"text":"aforementioned IST-3 trial subgroup analysis","text_display":" aforementioned IST-3 trial subgroup analysis","confidence":1,"confidence_rate":1},{"cnt":[[1137,1096],[1381,1096],[1381,1145],[1137,1145]],"region":{"top_left_x":1136,"top_left_y":1095,"width":246,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2e0413d91e740a5995f274e52e8171d","type":"form_field","conversion_output":true,"text":"","text_display":" □","subtype":"box"},{"cnt":[[1379,1096],[1796,1096],[1796,1145],[1379,1145]],"region":{"top_left_x":1379,"top_left_y":1095,"width":418,"height":51},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89bea5447c4f47218350dc17a2d71025","type":"text","conversion_output":true,"text":", personal communication).","text_display":" , personal communication).","confidence":1,"confidence_rate":1},{"cnt":[[430,1186],[1766,1186],[1766,1229],[430,1229]],"region":{"top_left_x":429,"top_left_y":1185,"width":1338,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df69f00608b640f081df5c9b9f6ac5c7","type":"text","conversion_output":true,"text":"The most prevalently reported and life-threatening adverse event (AE) associated with","text_display":"\n\nThe most prevalently reported and life-threatening adverse event (AE) associated with","confidence":1,"confidence_rate":1},{"cnt":[[432,1233],[1747,1233],[1747,1276],[432,1276]],"region":{"top_left_x":431,"top_left_y":1233,"width":1316,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fb086aabd8a4081b1e1a470b86e14f8","type":"text","conversion_output":true,"text":"alteplase treatment for acute ischemic stroke is symptomatic intracranial hemorrhage","text_display":" alteplase treatment for acute ischemic stroke is symptomatic intracranial hemorrhage","confidence":1,"confidence_rate":1},{"cnt":[[432,1280],[1768,1280],[1768,1326],[432,1326]],"region":{"top_left_x":431,"top_left_y":1280,"width":1338,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cd53698bc764481872756559796e900","type":"text","conversion_output":true,"text":"(sICH). Post hoc analyses, case series, and retrospective studies in patients with mild","text_display":" (sICH). Post hoc analyses, case series, and retrospective studies in patients with mild","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[430,1328],[1747,1328],[1747,1371],[430,1371]],"region":{"top_left_x":429,"top_left_y":1327,"width":1318,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e14921bc38524bb2b489c76534c7d0d3","type":"text","conversion_output":true,"text":"stroke suggest an absolute sICH rate of \\(0-2 \\%\\) with alteplase treatment (NINDS rt-PA","text_display":" stroke suggest an absolute sICH rate of \\(0-2 \\%\\) with alteplase treatment (NINDS rt-PA","confidence":0.8067348003387451,"confidence_rate":0.9976166193411823},{"cnt":[[430,1375],[1678,1375],[1678,1418],[430,1418]],"region":{"top_left_x":429,"top_left_y":1375,"width":1249,"height":43},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"878f6e35b58a40189ac660842cbc1a4f","type":"text","conversion_output":true,"text":"Study Group 2005; Baumann 2006; Gonzales et al. 2006; Köhrmann et al. 2009;","text_display":" Study Group 2005; Baumann 2006; Gonzales et al. 2006; Köhrmann et al. 2009;","confidence":1,"confidence_rate":1},{"cnt":[[432,1422],[1777,1422],[1777,1467],[432,1467]],"region":{"top_left_x":431,"top_left_y":1422,"width":1346,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a59166972914f9383cac786b025a38e","type":"text","conversion_output":true,"text":"Steffenhagen et al. 2009; Hassan et al. 2010a; Hassan et al. 2010b; Huisa et al. 2012).","text_display":" Steffenhagen et al. 2009; Hassan et al. 2010a; Hassan et al. 2010b; Huisa et al. 2012).","confidence":1,"confidence_rate":1},{"cnt":[[430,1470],[1747,1470],[1747,1515],[430,1515]],"region":{"top_left_x":429,"top_left_y":1469,"width":1318,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba02c9a4e17343319b2f24a910da9a31","type":"text","conversion_output":true,"text":"These data are consistent with analyses of IV alteplase trials of more severe patients","text_display":" These data are consistent with analyses of IV alteplase trials of more severe patients","confidence":1,"confidence_rate":1},{"cnt":[[432,1517],[1772,1517],[1772,1562],[432,1562]],"region":{"top_left_x":431,"top_left_y":1516,"width":1342,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e5eb4a53c954b1298c6520341ac6138","type":"text","conversion_output":true,"text":"suggesting that stroke severity, as measured by the NIHSS score, is a strong predictor","text_display":" suggesting that stroke severity, as measured by the NIHSS score, is a strong predictor","confidence":1,"confidence_rate":1},{"cnt":[[430,1564],[1796,1564],[1796,1609],[430,1609]],"region":{"top_left_x":429,"top_left_y":1564,"width":1368,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58850b8ba39047d7acf9d0b79a59b1eb","type":"text","conversion_output":true,"text":"of sICH risk (Khatri et al. 2007). No data exist to estimate the sICH rate for patients with","text_display":" of sICH risk (Khatri et al. 2007). No data exist to estimate the sICH rate for patients with","confidence":1,"confidence_rate":1},{"cnt":[[430,1611],[1764,1611],[1764,1656],[430,1656]],"region":{"top_left_x":429,"top_left_y":1611,"width":1335,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20b83880554d42889e538ebb9e32795e","type":"text","conversion_output":true,"text":"mild stroke who did not receive t-PA; therefore, for this study, we are using a \\(0 \\%\\) sICH","text_display":" mild stroke who did not receive t-PA; therefore, for this study, we are using a \\(0 \\%\\) sICH","confidence":0.9912188034504652,"confidence_rate":0.9999071624311765},{"cnt":[[430,1659],[1717,1659],[1717,1704],[430,1704]],"region":{"top_left_x":429,"top_left_y":1658,"width":1288,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cba7a9d305a5477f94909ab4d365995c","type":"text","conversion_output":true,"text":"rate for the placebo arm, which is likely a conservative estimate. An absolute sICH","text_display":" rate for the placebo arm, which is likely a conservative estimate. An absolute sICH","confidence":1,"confidence_rate":1},{"cnt":[[430,1706],[1682,1706],[1682,1751],[430,1751]],"region":{"top_left_x":429,"top_left_y":1705,"width":1254,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5baa8bbb0f41422b9515788545863cc3","type":"text","conversion_output":true,"text":"difference of \\(2 \\%\\) at 36 hours (primary safety endpoint) has been assumed for the","text_display":" difference of \\(2 \\%\\) at 36 hours (primary safety endpoint) has been assumed for the","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[432,1755],[1755,1755],[1755,1798],[432,1798]],"region":{"top_left_x":431,"top_left_y":1755,"width":1325,"height":44},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c47ec0f75d2472099a1f99f6f5af005","type":"text","conversion_output":true,"text":"alteplase arm vs. the placebo control arm in the proposed study. For this study, sICH","text_display":" alteplase arm vs. the placebo control arm in the proposed study. For this study, sICH","confidence":1,"confidence_rate":1},{"cnt":[[430,1800],[1772,1800],[1772,1846],[430,1846]],"region":{"top_left_x":429,"top_left_y":1800,"width":1344,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb9c092d6e2440e3b623bd48db5f8366","type":"text","conversion_output":true,"text":"has been defined as any neurologic decline attributed to intracranial hemorrhage (ICH)","text_display":" has been defined as any neurologic decline attributed to intracranial hemorrhage (ICH)","confidence":0.9970703125,"confidence_rate":0.999967758899593},{"cnt":[[432,1850],[1760,1850],[1760,1893],[432,1893]],"region":{"top_left_x":431,"top_left_y":1849,"width":1329,"height":44},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8720a62b21246e6819dd5db034d511a","type":"text","conversion_output":true,"text":"seen on imaging by the local investigator within 36 hours of study drug administration,","text_display":" seen on imaging by the local investigator within 36 hours of study drug administration,","confidence":1,"confidence_rate":1},{"cnt":[[430,1897],[1727,1897],[1727,1944],[430,1944]],"region":{"top_left_x":429,"top_left_y":1897,"width":1299,"height":48},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dba6f7a5f7154658ade54b9b5744deaa","type":"text","conversion_output":true,"text":"consistent with the NINDS trial definition for sICH (NINDS rt-PA Study Group 1995).","text_display":" consistent with the NINDS trial definition for sICH (NINDS rt-PA Study Group 1995).","confidence":1,"confidence_rate":1},{"cnt":[[430,1985],[1757,1985],[1757,2030],[430,2030]],"region":{"top_left_x":429,"top_left_y":1985,"width":1329,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eafc83459ba64724ba4a350648821a0b","type":"text","conversion_output":true,"text":"Assuming the proposed study demonstrates both a \\(9 \\%\\) absolute treatment effect rate,","text_display":"\n\nAssuming the proposed study demonstrates both a \\(9 \\%\\) absolute treatment effect rate,","confidence":1,"confidence_rate":1},{"cnt":[[430,2032],[1766,2032],[1766,2078],[430,2078]],"region":{"top_left_x":429,"top_left_y":2032,"width":1338,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28c01623bb4841e08ee3d766c06bfc81","type":"text","conversion_output":true,"text":"the number of patients needed to treat (NNT) to show benefit (i.e., mRS score of \\(0-1\\) )","text_display":" the number of patients needed to treat (NNT) to show benefit (i.e., mRS score of \\(0-1\\) )","confidence":0.8652554706914088,"confidence_rate":0.9985537421022563},{"cnt":[[430,2080],[1800,2080],[1800,2125],[430,2125]],"region":{"top_left_x":429,"top_left_y":2079,"width":1372,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a757612575874cffbda816e75afb2d78","type":"text","conversion_output":true,"text":"for one patient is 11 . Assuming a \\(2 \\%\\) absolute difference in sICH rate in patients treated","text_display":" for one patient is 11 . Assuming a \\(2 \\%\\) absolute difference in sICH rate in patients treated","confidence":0.9853813648223877,"confidence_rate":0.9998542032993382},{"cnt":[[430,2127],[1648,2127],[1648,2172],[430,2172]],"region":{"top_left_x":429,"top_left_y":2126,"width":1219,"height":47},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b6e162f3e7c4f8087772a5ade502644","type":"text","conversion_output":true,"text":"with alteplase, the corresponding value for the number needed to harm (NNH),","text_display":" with alteplase, the corresponding value for the number needed to harm (NNH),","confidence":1,"confidence_rate":1},{"cnt":[[430,2174],[1772,2174],[1772,2219],[430,2219]],"region":{"top_left_x":429,"top_left_y":2174,"width":1344,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"794a66da0a5940f988a2a125f50555c2","type":"text","conversion_output":true,"text":"specifically for sICH, is conservatively estimated to be 50 . The actual number NNH, or","text_display":" specifically for sICH, is conservatively estimated to be 50 . The actual number NNH, or","confidence":0.7948312759399414,"confidence_rate":0.9975858091902683},{"cnt":[[430,2221],[1699,2221],[1699,2267],[430,2267]],"region":{"top_left_x":429,"top_left_y":2221,"width":1271,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd4412bb6ab348788480ce7276b5a1d9","type":"text","conversion_output":true,"text":"the number of patients who would have worse outcomes at 90 days with alteplase","text_display":" the number of patients who would have worse outcomes at 90 days with alteplase","confidence":1,"confidence_rate":1},{"cnt":[[432,2269],[1790,2269],[1790,2314],[432,2314]],"region":{"top_left_x":431,"top_left_y":2268,"width":1359,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ff8cb002cbe401d9e175eb35079605f","type":"text","conversion_output":true,"text":"compared to placebo treatment, is likely to be much higher than is reflected by the sICH","text_display":" compared to placebo treatment, is likely to be much higher than is reflected by the sICH","confidence":0.9951229095458984,"confidence_rate":0.9999474312498433},{"cnt":[[432,2316],[1807,2316],[1807,2361],[432,2361]],"region":{"top_left_x":431,"top_left_y":2316,"width":1376,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9c2c16dd672411bb96692e32b8d9c1c","type":"text","conversion_output":true,"text":"rate alone, as many patients who experience sICH have severe baseline infarcts and are","text_display":" rate alone, as many patients who experience sICH have severe baseline infarcts and 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Other","text_display":" alteplase placebo plus aspirin 325 mg ; hence, this is an active-comparator trial. Other","confidence":1,"confidence_rate":1},{"cnt":[[434,1259],[1783,1259],[1783,1300],[434,1300]],"region":{"top_left_x":433,"top_left_y":1258,"width":1351,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"144bbcb5e5074299beae2ede964612c9","type":"text","conversion_output":true,"text":"than the study intervention, patients will receive standard of care for AIS at the enrolling","text_display":" than the study intervention, patients will receive standard of care for AIS at the enrolling","confidence":1,"confidence_rate":1},{"cnt":[[434,1308],[1721,1308],[1721,1349],[434,1349]],"region":{"top_left_x":433,"top_left_y":1308,"width":1288,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8dd1f4f76a44d4eaee8af5beb48719c","type":"text","conversion_output":true,"text":"institutions. The primary endpoint using the mRS assessment of global disability at","text_display":" institutions. 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(For comparison, the two NINDS","text_display":" across approximately 75 sites in North America. 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As described in Section 1.3,","text_display":" approximately 75 clinical sites within North America. As described in Section 1.3,","confidence":0.9960966110229492,"confidence_rate":0.9999565450877186},{"cnt":[[432,541],[1749,541],[1749,587],[432,587]],"region":{"top_left_x":431,"top_left_y":541,"width":1318,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bba0d58378424316997e664b91a1ea3e","type":"text","conversion_output":true,"text":"eligible patients with mild stroke will be enrolled in this study. Currently, the alteplase","text_display":" eligible patients with mild stroke will be enrolled in this study. Currently, the alteplase","confidence":1,"confidence_rate":1},{"cnt":[[434,589],[1747,589],[1747,632],[434,632]],"region":{"top_left_x":433,"top_left_y":588,"width":1314,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a676bb1f386442eeb4a05ba82d12ac57","type":"text","conversion_output":true,"text":"USPI warns against the use of alteplase in patients with \"minor neurologic deficit and","text_display":" USPI warns against the use of alteplase in patients with \"minor neurologic deficit and","confidence":1,"confidence_rate":1},{"cnt":[[432,638],[1592,638],[1592,681],[432,681]],"region":{"top_left_x":431,"top_left_y":638,"width":1161,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a7a03b5ed554480b94d08b5321456c7","type":"text","conversion_output":true,"text":"rapidly improving stroke symptoms\" due to lack of data. Retrospective and","text_display":" rapidly improving stroke symptoms\" due to lack of data. Retrospective and","confidence":1,"confidence_rate":1},{"cnt":[[432,683],[1674,683],[1674,726],[432,726]],"region":{"top_left_x":431,"top_left_y":683,"width":1243,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f48f477437942bb9e230b3f317ecc97","type":"text","conversion_output":true,"text":"observational data suggest potential benefit of alteplase in these patients, with a","text_display":" observational data suggest potential benefit of alteplase in these patients, with a","confidence":1,"confidence_rate":1},{"cnt":[[430,730],[874,730],[874,776],[430,776]],"region":{"top_left_x":429,"top_left_y":730,"width":446,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6d7b5415e3f484b8be7bfda22e7dbb2","type":"text","conversion_output":true,"text":"favorable benefit-risk profile.","text_display":" favorable benefit-risk profile.","confidence":1,"confidence_rate":1},{"cnt":[[432,821],[1798,821],[1798,862],[432,862]],"region":{"top_left_x":431,"top_left_y":820,"width":1368,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0599e4a91c824edc995bed2188a07b6d","type":"text","conversion_output":true,"text":"The definition of mild stroke for PRISMS is an NIHSS score \\(\\leq 5\\) and not clearly disabling.","text_display":"\n\nThe definition of mild stroke for PRISMS is an NIHSS score \\(\\leq 5\\) and not clearly disabling.","confidence":0.998046875,"confidence_rate":0.9999796352611579},{"cnt":[[430,868],[1800,868],[1800,909],[430,909]],"region":{"top_left_x":429,"top_left_y":867,"width":1372,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a4e001d90ca443a8eccf07aac07e3a5","type":"text","conversion_output":true,"text":"This includes patients whose symptoms are persistently mild as well as those with RISS.","text_display":" This includes patients whose symptoms are persistently mild as well as those with RISS.","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[430,954],[1695,954],[1695,990],[430,990]],"region":{"top_left_x":429,"top_left_y":953,"width":1267,"height":38},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b89ab0e950b74ecdb1d273965321a220","type":"text","conversion_output":true,"text":"An NIHSS score \\(\\leq 5\\) was chosen as one criterion in the definition of mild stroke for","text_display":"\n\nAn NIHSS score \\(\\leq 5\\) was chosen as one criterion in the definition of mild stroke for","confidence":0.9990236759185791,"confidence_rate":0.9999891467144949},{"cnt":[[432,1001],[969,1001],[969,1042],[432,1042]],"region":{"top_left_x":431,"top_left_y":1001,"width":538,"height":41},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00c1efaa1c284d9eb216f68f60632972","type":"text","conversion_output":true,"text":"PRISMS for the following reasons:","text_display":" PRISMS for the following reasons:","confidence":1,"confidence_rate":1},{"cnt":[[434,1061],[1747,1061],[1747,1102],[434,1102]],"region":{"top_left_x":433,"top_left_y":1061,"width":1314,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"529e1006b8d145e7be2787e90d700588","type":"text","conversion_output":true,"text":"1. An NIHSS score \\(\\leq 5\\) is commonly used as an exclusion criterion for many current","text_display":"\n1. An NIHSS score \\(\\leq 5\\) is commonly used as an exclusion criterion for many current","confidence":0.9970703125,"confidence_rate":0.9999666597894927},{"cnt":[[498,1106],[1772,1106],[1772,1149],[498,1149]],"region":{"top_left_x":498,"top_left_y":1106,"width":1275,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6e5d391e349483485de20b8f5aeab9a","type":"text","conversion_output":true,"text":"AIS studies, suggesting that these patients are underrepresented in current stroke","text_display":" AIS studies, suggesting that these patients are underrepresented in current stroke","confidence":1,"confidence_rate":1},{"cnt":[[498,1152],[1777,1152],[1777,1192],[498,1192]],"region":{"top_left_x":498,"top_left_y":1151,"width":1279,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"867d9627f35849adb6447a6bef85265a","type":"text","conversion_output":true,"text":"research and are treated differently by the stroke community, as shown in Table 2.","text_display":" research and are treated differently by the stroke community, as shown in Table 2.","confidence":1,"confidence_rate":1},{"cnt":[[430,1207],[1777,1207],[1777,1253],[430,1253]],"region":{"top_left_x":429,"top_left_y":1207,"width":1348,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33e1fef695634000bd6e8bae56726eae","type":"text","conversion_output":true,"text":"2. The largest retrospective analysis of mild stroke from the Get With the Guidelines \\({ }^{\\circledR}\\)","text_display":"\n2. The largest retrospective analysis of mild stroke from the Get With the Guidelines \\({ }^{\\circledR}\\)","confidence":0.90869140625,"confidence_rate":0.9990234390899749},{"cnt":[[501,1255],[1796,1255],[1796,1298],[501,1298]],"region":{"top_left_x":500,"top_left_y":1254,"width":1297,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82b8d9492dc84b0d81870ddf58d056ef","type":"text","conversion_output":true,"text":"registry included 29,200 stroke patients who did not receive alteplase due to mild or","text_display":" registry included 29,200 stroke patients who did not receive alteplase due to mild or","confidence":0.9726693630218506,"confidence_rate":0.9997020759317968},{"cnt":[[498,1298],[1800,1298],[1800,1343],[498,1343]],"region":{"top_left_x":498,"top_left_y":1297,"width":1303,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48f64880e69b4bc2a51656732df5b49f","type":"text","conversion_output":true,"text":"improving symptoms. This analysis found that \\(80.1 \\%\\) of patients with mild or rapidly","text_display":" improving symptoms. This analysis found that \\(80.1 \\%\\) of patients with mild or rapidly","confidence":1,"confidence_rate":1},{"cnt":[[501,1343],[1768,1343],[1768,1386],[501,1386]],"region":{"top_left_x":500,"top_left_y":1342,"width":1269,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"254c39be1fa2423f9168314a181ae8c8","type":"text","conversion_output":true,"text":"improving stroke who did not receive alteplase (and had a recorded NIHSS score)","text_display":" improving stroke who did not receive alteplase (and had a recorded NIHSS score)","confidence":1,"confidence_rate":1},{"cnt":[[501,1388],[1265,1388],[1265,1431],[501,1431]],"region":{"top_left_x":500,"top_left_y":1387,"width":766,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd1fe658c2504a76a7eb53f167f46b7c","type":"text","conversion_output":true,"text":"had an initial NIHSS score \\(\\leq 5\\) (Smith et al. 2011).","text_display":" had an initial NIHSS score \\(\\leq 5\\) (Smith et al. 2011).","confidence":0.9990236759185791,"confidence_rate":0.999983158745329},{"cnt":[[434,1470],[1800,1470],[1800,1515],[434,1515]],"region":{"top_left_x":433,"top_left_y":1469,"width":1368,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fda520778eec4154beef62aa54589eed","type":"text","conversion_output":true,"text":"Based on these findings, an NIHSS score \\(\\leq 5\\) was determined to be the most appropriate","text_display":"\n\nBased on these findings, an NIHSS score \\(\\leq 5\\) was determined to be the most appropriate","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[432,1517],[1280,1517],[1280,1562],[432,1562]],"region":{"top_left_x":431,"top_left_y":1516,"width":850,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1c6f2db0f504f0e8316fc57800a3e7a","type":"text","conversion_output":true,"text":"cut-off to define the patient population with mild stroke.","text_display":" cut-off to define the patient population with mild stroke.","confidence":1,"confidence_rate":1},{"cnt":[[430,2423],[844,2423],[844,2460],[430,2460]],"region":{"top_left_x":429,"top_left_y":2423,"width":416,"height":37},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b0e7740052d45ecaa91ffd205100415","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936649702746081,"confidence_rate":0.999788183063776},{"cnt":[[432,2462],[846,2462],[846,2496],[432,2496]],"region":{"top_left_x":431,"top_left_y":2462,"width":416,"height":35},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a10970cf9d3a4f77ab678ec1419acda8","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1766,2462],[1818,2462],[1818,2505],[1766,2505]],"region":{"top_left_x":1766,"top_left_y":2462,"width":52,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfd871326def461eaf5dc357d940fd3c","type":"page_info","conversion_output":false,"text":"36","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78e91d9891c3440396d5c5200ffeb63e","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9917199394067194,"confidence_rate":0.999872092323911},{"cnt":[[372,2608],[694,2608],[694,2643],[372,2643]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":35},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4faf4007d6524a848950ee47c9e8a855","type":"page_info","conversion_output":false,"text":"468/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-133","page":133,"lines":[{"cnt":[[425,335],[1742,335],[1742,425],[425,425]],"region":{"top_left_x":425,"top_left_y":335,"width":1318,"height":91},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccf9d0f0f36f442099490315e394affd","type":"figure_label","conversion_output":false,"children_ids":["4858fc0e8a174ba69521a584918bbd6e","4162f79391a749f09ef6465d02e0c2de"],"text":"","text_display":""},{"cnt":[[430,339],[1738,339],[1738,385],[430,385]],"region":{"top_left_x":429,"top_left_y":339,"width":1310,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4858fc0e8a174ba69521a584918bbd6e","type":"text","conversion_output":false,"parent_id":"ccf9d0f0f36f442099490315e394affd","text":"Table 2 NIHSS Exclusion Criteria of Recently Completed and Ongoing","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999934000150488},{"cnt":[[610,385],[1141,385],[1141,423],[610,423]],"region":{"top_left_x":610,"top_left_y":384,"width":531,"height":40},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4162f79391a749f09ef6465d02e0c2de","type":"text","conversion_output":false,"parent_id":"ccf9d0f0f36f442099490315e394affd","text":"Acute Ischemic Stroke Trials","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[413,447],[1820,447],[1820,1525],[413,1525]],"region":{"top_left_x":412,"top_left_y":446,"width":1408,"height":1080},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83c5551d93c64e66a4716f0334aafdfc","type":"table","conversion_output":true,"children_ids":["9b039f51ddb74934860832866bb80994","f620a092013f46858e1a3974ba92f115","d90cdcf1c4b445b4ba0544491002de66","5166279939ce402cbfefa9091ab5fc2b","e5348b90aa4f47a7b39bd1cae50b399c","71943baf11ab48eb9f93ce088b01cc71","f769eceb6e6843d5b4ed9927e60d267a","3e27f0ec911042cabf3573d933a70c7a","844eb53c74594e82a247d8001afabcc6","f5924fabf67b40839f519ae497e21ed1","d920fd48e1f44c63871c1e0647537c9b","e5dadfe007a24883b0d41e2c2769fa0c","c36284fbad114af0af290de6eaa7cec7","53aadeeaad46447eba2e98b29a568624","69266b1190874ee08aaa17a63af9b7e7","d86b8ed4e42f4704909959e6ec4751df","a1a2abec92804093a297fae0147e5522","5a34891fe81b460bba6cf565f2f92484","4a8f7d4b8a10443e99c8d99df50c1832","53380c942fb24ad6bfbdde28596ad6f4","102c9a7f25c74a01878d46ca174c0736","01567aa1829c44bd82bc5234dbfccd97","e0cdbd6332354edcb567bb3f1762957c","e5e7a245a515450ebf8be610cd361b61","555d336c4b4e42dd9ba0475c52233657","f5e347828b7c43ff957b4cfedecf7a1d","d96c0a19f39e466b8500c4ce7a66d34c","d5e8263d254a40c09b063766b9301994","802b1ebfd4eb410181e96de5d5877a53","5fcdc3fc5288451bb9b37aa64da26e3b","8e488df81d4543bfa8ced007895919c0","1ecc12f452034790bd0d05ee21f501f8","903fec3d8903430cad939386aac84d61","9e6f797af9be485094ddc834dea6b293","46d26b79741344fca163deaed9f5f0b8","9564dfc6ffe145558f9e0c260df3fca4","92835403b46146b4890e0fcee61fd9a7","e4d05bcec57b43d4b18ccfe1386942ae","381fabd5bbc84ec3885d48a7a64045d1","8a37ec41df3a4dfc834680ae4c200a7b","9ff43c79eca646858439a262bbb3ace4","ba6dab6d47644e49877375944e9f6c51","176f50fe0d7f477da7dbd5e01b806dee","6d85909c91074661aff31fbc3354f1ea","0f798f7c7cd743f5aedbfbd2ddbbf34e","789fc87a16af4df28c3f787c6d1ecaee","b53f18fcc07a40ac9f12c04b27eaf24c"],"selected_labels":["ccf9d0f0f36f442099490315e394affd"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline Recently Completed AIS Trials & Exclusion & Ongoing AIS Trials & Exclusion \\\\\n\\hline Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke (CLEAR Stroke) Trial & \\(NIHSS \\leq 5\\) & ARTSS & NIHSS \\(\\leq 9\\) \\\\\n\\hline Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke & \\(NIHSS \\leq 6\\) & SHINE & NIHSS < 3 \\\\\n\\hline Albumin in Acute Ischemic Stroke Trial (ALIAS) Part One & \\(NIHSS \\leq 5\\) & The Intravascular Cooling in the Treatment of Stroke 2/3 (ICTuS 2/3) Trial (ICTuS2/3) & NIHSS \\(\\leq 6\\) \\\\\n\\hline Study of the Combination Therapy of rt-PA and Eptifibati5.3.3.8de to Treat Acute Ischemic Stroke (CLEAR-ER) & \\(NIHSS \\leq 5\\) & Safety/Feasibility of Autologous Mononuclear Bone Marrow Cells in Stroke Patients & NIHSS \\(\\leq 5\\) \\\\\n\\hline Albumin in Acute Ischemic Stroke Trial (ALIAS) Part Two & NIHSS \\(\\leq 5\\) & SWIFT PRIME & NIHSS \\(\\leq 7\\) \\\\\n\\hline Mechanical Retrieval 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However, PRISMS combines these two patient groups into","text_display":" deficit from those with RISS. 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who improve to an NIHSS score>5 at the time of treatment","confidence":0.753777027130127,"confidence_rate":0.9965588772719808},{"cnt":[[430,391],[1691,391],[1691,436],[430,436]],"region":{"top_left_x":429,"top_left_y":391,"width":1262,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c97501289b24316ba199276641c7b30","type":"text","conversion_output":true,"text":"decision will be excluded from PRISMS as they are not considered to have RISS.","text_display":" decision will be excluded from PRISMS as they are not considered to have RISS.","confidence":1,"confidence_rate":1},{"cnt":[[430,438],[1721,438],[1721,483],[430,483]],"region":{"top_left_x":429,"top_left_y":438,"width":1292,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a78af552b80c4e9280994f0c9e4eaca6","type":"text","conversion_output":true,"text":"Current clinical practice suggests that these patients would still have a moderate or","text_display":" Current clinical practice suggests that these patients would still have a moderate or","confidence":1,"confidence_rate":1},{"cnt":[[430,488],[1768,488],[1768,531],[430,531]],"region":{"top_left_x":429,"top_left_y":487,"width":1340,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f8700f58b594d709a57884accb55e74","type":"text","conversion_output":true,"text":"severe stroke at the time of treatment decision and should receive alteplase, if eligible,","text_display":" severe stroke at the time of treatment decision and should receive alteplase, if eligible,","confidence":1,"confidence_rate":1},{"cnt":[[430,535],[1751,535],[1751,578],[430,578]],"region":{"top_left_x":429,"top_left_y":534,"width":1322,"height":44},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52af096466134cb7953ae270688ddf61","type":"text","conversion_output":true,"text":"rather than be randomized to a study. Such patients should not be defined as rapidly","text_display":" rather than be randomized to a study. Such patients should not be defined as rapidly","confidence":1,"confidence_rate":1},{"cnt":[[430,580],[1747,580],[1747,625],[430,625]],"region":{"top_left_x":429,"top_left_y":580,"width":1318,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d59a8bef7cc4d3eba24f22f75f93019","type":"text","conversion_output":true,"text":"improving, given that they have not improved to an NIHSS score low enough to merit","text_display":" improving, given that they have not improved to an NIHSS score low enough to merit","confidence":1,"confidence_rate":1},{"cnt":[[430,629],[1699,629],[1699,672],[430,672]],"region":{"top_left_x":429,"top_left_y":629,"width":1271,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69da58f51bf44883a12bc1e986bb6420","type":"text","conversion_output":true,"text":"withholding therapy. This definition of RISS is consistent with a recent consensus","text_display":" withholding therapy. 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These clearly disabling deficits at presentation may include, but are","text_display":" clearly disabled. 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Patients with clearly disabling deficits will be","text_display":" hemineglect, or cortical blindness. Patients with clearly disabling deficits will be","confidence":1,"confidence_rate":1},{"cnt":[[430,954],[1749,954],[1749,999],[430,999]],"region":{"top_left_x":429,"top_left_y":953,"width":1320,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0eea71b2395a4e118e7bd42bc8ad82bb","type":"text","conversion_output":true,"text":"excluded from this study irrespective of the NIHSS score at time of randomization, as","text_display":" excluded from this study irrespective of the NIHSS score at time of randomization, as","confidence":1,"confidence_rate":1},{"cnt":[[430,1001],[1772,1001],[1772,1046],[430,1046]],"region":{"top_left_x":429,"top_left_y":1001,"width":1344,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fac91922c1ed4f7bbabb0cb390ce5cfc","type":"text","conversion_output":true,"text":"current clinical practice and ethical responsibility suggest that these patients should be","text_display":" current clinical practice and ethical responsibility suggest that these patients should be","confidence":1,"confidence_rate":1},{"cnt":[[430,1048],[1794,1048],[1794,1094],[430,1094]],"region":{"top_left_x":429,"top_left_y":1048,"width":1365,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0d1957526de40779193f5a29b804234","type":"text","conversion_output":true,"text":"evaluated to receive alteplase rather than be enrolled in a randomized study where they","text_display":" evaluated to receive alteplase rather than be enrolled in a randomized study where they","confidence":1,"confidence_rate":1},{"cnt":[[430,1096],[913,1096],[913,1141],[430,1141]],"region":{"top_left_x":429,"top_left_y":1095,"width":485,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b182e7b625840558ef75c125fdd2f97","type":"text","conversion_output":true,"text":"may receive alteplase placebo.","text_display":" may receive alteplase placebo.","confidence":0.9990234375,"confidence_rate":0.9999720849711223},{"cnt":[[425,1173],[1173,1173],[1173,1231],[425,1231]],"region":{"top_left_x":425,"top_left_y":1173,"width":749,"height":59},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a2efe6cfd6a4f4a9c477c0cebd673fd","type":"section_header","conversion_output":false,"children_ids":["69e4f523bfad4c80bd7a74eed293511a"],"text":"","text_display":""},{"cnt":[[432,1177],[1167,1177],[1167,1227],[432,1227]],"region":{"top_left_x":431,"top_left_y":1177,"width":736,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69e4f523bfad4c80bd7a74eed293511a","type":"text","conversion_output":true,"parent_id":"2a2efe6cfd6a4f4a9c477c0cebd673fd","text":"3.4.3 Rationale for Control Group","text_display":"\n\n\\subsection*{3.4.3 Rationale for Control Group}","confidence":0.9990236759185791,"confidence_rate":0.999974295041004},{"cnt":[[430,1237],[1652,1237],[1652,1283],[430,1283]],"region":{"top_left_x":429,"top_left_y":1237,"width":1224,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2aca47e5896945169d2a37e85ba45b47","type":"text","conversion_output":true,"text":"The overall rationale for this trial is to determine whether IV alteplase improves","text_display":"\n\nThe overall rationale for this trial is to determine whether IV alteplase improves","confidence":1,"confidence_rate":1},{"cnt":[[430,1285],[1772,1285],[1772,1330],[430,1330]],"region":{"top_left_x":429,"top_left_y":1284,"width":1344,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5fd6625190448c884cdd867064984f2","type":"text","conversion_output":true,"text":"outcomes in patients with mild stroke. The control group (i.e., mild stroke patients who","text_display":" outcomes in patients with mild stroke. 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Details on MRI types are described in","confidence":1,"confidence_rate":1},{"cnt":[[434,1263],[690,1263],[690,1300],[434,1300]],"region":{"top_left_x":433,"top_left_y":1263,"width":257,"height":37},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c20abd2618ce42fa9cd72f7e23cbfeed","type":"text","conversion_output":true,"text":"Section 4.5.1.6.","text_display":" Section 4.5.1.6.","confidence":1,"confidence_rate":1},{"cnt":[[434,1349],[1772,1349],[1772,1394],[434,1394]],"region":{"top_left_x":433,"top_left_y":1349,"width":1340,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db6f2675fc8d45f8be53b08d044f3503","type":"text","conversion_output":true,"text":"Intracranial hemorrhage events will include classifications of intracerebral hemorrhage","text_display":"\n\nIntracranial hemorrhage events will include classifications of intracerebral hemorrhage","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[434,1396],[1695,1396],[1695,1437],[434,1437]],"region":{"top_left_x":433,"top_left_y":1396,"width":1263,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a51a477f0d2a474ba7beff9105cf8a3c","type":"text","conversion_output":true,"text":"(hemorrhagic infarct type 1 or type 2, parenchymal hematoma type 1 or type 2, or","text_display":" (hemorrhagic infarct type 1 or type 2, parenchymal hematoma type 1 or type 2, or","confidence":0.9690063167363405,"confidence_rate":0.9996540801924879},{"cnt":[[434,1444],[1755,1444],[1755,1489],[434,1489]],"region":{"top_left_x":433,"top_left_y":1443,"width":1323,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20f7ff48cd6a40099bb5f52d7772c5fc","type":"text","conversion_output":true,"text":"remote intraparenchymal hemorrhage type 1 or type 2). Descriptions of each type of","text_display":" remote intraparenchymal hemorrhage type 1 or type 2). Descriptions of each type of","confidence":0.9814708151388913,"confidence_rate":0.9997922104727288},{"cnt":[[434,1491],[1738,1491],[1738,1536],[434,1536]],"region":{"top_left_x":433,"top_left_y":1491,"width":1306,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2920bf744383477f8d8463c64eed2dd0","type":"text","conversion_output":true,"text":"intracerebral hemorrhage are shown in the table below. Additionally, subarachnoid","text_display":" intracerebral hemorrhage are shown in the table below. Additionally, subarachnoid","confidence":1,"confidence_rate":1},{"cnt":[[434,1538],[1618,1538],[1618,1579],[434,1579]],"region":{"top_left_x":433,"top_left_y":1538,"width":1185,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc8f579e44a94a08852f7bf1a259adf2","type":"text","conversion_output":true,"text":"hemorrhage, subdural hemorrhage, or epidural hemorrhage should be noted.","text_display":" hemorrhage, subdural hemorrhage, or epidural hemorrhage should be noted.","confidence":1,"confidence_rate":1},{"cnt":[[430,1620],[1304,1620],[1304,1665],[430,1665]],"region":{"top_left_x":429,"top_left_y":1619,"width":876,"height":47},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d0375b307a54fe29f1064db8c035407","type":"figure_label","conversion_output":false,"text":"Table 3 Intracerebral Hemorrhage Definitions","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999906077268363},{"cnt":[[432,1684],[1807,1684],[1807,2299],[432,2299]],"region":{"top_left_x":431,"top_left_y":1684,"width":1376,"height":615},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"841b28dc5c654d1eabbce6967f860f36","type":"table","conversion_output":true,"children_ids":["9aeef59573a54322a8e1b09f5d0fef7d","0f017fcba6d54e48908f80a8933c0888","21ce15a03d414487b99599b9b1c5298d","428ffc7ba585469a993bbe7f8a34e56b","26409665073b4a50ad35968f9aa01b2e","ed5cfcac1dc243ca8188c4b0ab605a84","1332f0b7095f47d48bf24bfb5c69a931","1a63118b442d49908ca896666b212693","9c22a38fb7d943599aaf1ce4467fdf63","f5de0ef2b37c44698184f98b97df382a","62a68b778bfb4213bd0f0023a73baa7e","14ed76f960b240b4b8133c8770fde4e6","5a3290b6120e4f6ba33c1603eb1dccce","8bcf6ff7ef6a45e1b1e0cbc93925aca1","96c30fd91def49e79571cf2c4f86dacb","6df9215bf20a4b44a35ce52243ec08a4","85e8364490a14c60977d3123020f07ee","24dc8232a53d45f884e0c46ad7825c1a","b8126d4721e043ee94437bf84b10b547","3e2681d8f8a946899197317aa60bb69b","01ba1ac31e3545e2a9d2baa86c79bfc1","125c4c1d95be451b82c7a99582ff3d84","e3d1b1d66a83444d8913aeeb7294ff27"],"selected_labels":["9d0375b307a54fe29f1064db8c035407"],"text":"\\begin{tabular}{|l|l|}\n\\hline Type & Description \\\\\n\\hline HI type 1 & Small petechiae along margin of infarct \\\\\n\\hline HI type 2 & More confluent petechiae within the infarcted area but without spaceoccupying effect \\\\\n\\hline PH type 1 & Hematoma in \\(\\leq 30 \\%\\) of the infarcted area with some slight space-occupying effect \\\\\n\\hline PH type 2 & Dense hematoma \\(>30 \\%\\) total of the infarcted area with substantial spaceoccupying effect or any hemorrhagic area outside the infarcted area \\\\\n\\hline rPH type 1 & Small or medium sized blood clots located remote from the actual infarct; a mild space-occupying effect could be present. Remote primary intracerebral hemorrhage \\\\\n\\hline rPH type 2 & Large confluent dense blood clots in an area remote from the actual infarct; substantial space-occupying effect might be present. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3 Intracerebral Hemorrhage Definitions}\n\\begin{tabular}{|l|l|}\n\\hline Type & Description \\\\\n\\hline HI type 1 & Small petechiae along margin of infarct \\\\\n\\hline HI type 2 & More confluent petechiae within the infarcted area but without spaceoccupying effect \\\\\n\\hline PH type 1 & Hematoma in \\(\\leq 30 \\%\\) of the infarcted area with some slight space-occupying effect \\\\\n\\hline PH type 2 & Dense hematoma \\(>30 \\%\\) total of the infarcted area with substantial spaceoccupying effect or any hemorrhagic area outside the infarcted area \\\\\n\\hline rPH type 1 & Small or medium sized blood clots located remote from the actual infarct; a mild space-occupying effect could be present. Remote primary intracerebral hemorrhage \\\\\n\\hline rPH type 2 & Large confluent dense blood clots in an area remote from the actual infarct; substantial space-occupying effect might be present. \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.98876953125,"confidence_rate":0.9999868424280173},{"cnt":[[437,1684],[600,1684],[600,2297],[437,2297]],"region":{"top_left_x":437,"top_left_y":1684,"width":163,"height":613},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9aeef59573a54322a8e1b09f5d0fef7d","type":"table_column","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"","text_display":""},{"cnt":[[719,1684],[1789,1684],[1789,2297],[719,2297]],"region":{"top_left_x":719,"top_left_y":1684,"width":1070,"height":613},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f017fcba6d54e48908f80a8933c0888","type":"table_column","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"","text_display":""},{"cnt":[[431,1697],[1808,1697],[1808,1742],[431,1742]],"region":{"top_left_x":431,"top_left_y":1696,"width":1378,"height":47},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21ce15a03d414487b99599b9b1c5298d","type":"table_row","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"","text_display":""},{"cnt":[[431,1749],[1806,1749],[1806,1794],[431,1794]],"region":{"top_left_x":431,"top_left_y":1748,"width":1376,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"428ffc7ba585469a993bbe7f8a34e56b","type":"table_row","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"","text_display":""},{"cnt":[[431,1805],[1806,1805],[1806,1890],[431,1890]],"region":{"top_left_x":431,"top_left_y":1805,"width":1376,"height":85},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26409665073b4a50ad35968f9aa01b2e","type":"table_row","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"","text_display":""},{"cnt":[[431,1896],[1806,1896],[1806,1976],[431,1976]],"region":{"top_left_x":431,"top_left_y":1896,"width":1376,"height":81},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed5cfcac1dc243ca8188c4b0ab605a84","type":"table_row","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"","text_display":""},{"cnt":[[431,1987],[1806,1987],[1806,2074],[431,2074]],"region":{"top_left_x":431,"top_left_y":1987,"width":1376,"height":87},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1332f0b7095f47d48bf24bfb5c69a931","type":"table_row","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"","text_display":""},{"cnt":[[431,2082],[1806,2082],[1806,2202],[431,2202]],"region":{"top_left_x":431,"top_left_y":2082,"width":1376,"height":120},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a63118b442d49908ca896666b212693","type":"table_row","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"","text_display":""},{"cnt":[[431,2210],[1806,2210],[1806,2295],[431,2295]],"region":{"top_left_x":431,"top_left_y":2210,"width":1376,"height":85},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c22a38fb7d943599aaf1ce4467fdf63","type":"table_row","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"","text_display":""},{"cnt":[[442,1701],[520,1701],[520,1738],[442,1738]],"region":{"top_left_x":441,"top_left_y":1701,"width":79,"height":38},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5de0ef2b37c44698184f98b97df382a","type":"simple_cell","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"Type","text_display":"Type","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1172,1697],[1351,1697],[1351,1738],[1172,1738]],"region":{"top_left_x":1171,"top_left_y":1696,"width":181,"height":43},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62a68b778bfb4213bd0f0023a73baa7e","type":"simple_cell","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"Description","text_display":"Description","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[444,1755],[572,1755],[572,1792],[444,1792]],"region":{"top_left_x":443,"top_left_y":1755,"width":129,"height":38},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14ed76f960b240b4b8133c8770fde4e6","type":"simple_cell","conversion_output":false,"parent_id":"841b28dc5c654d1eabbce6967f860f36","text":"HI 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IWRS will assign a new pair of drug kit IDs for the next patient that becomes eligible","text_display":"\n2. 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IWRS will then","text_display":"\nenter drug kit IDs into IWRS and indicate that the kits were not used. IWRS will then","confidence":1,"confidence_rate":1},{"cnt":[[430,391],[1772,391],[1772,436],[430,436]],"region":{"top_left_x":429,"top_left_y":391,"width":1344,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6eee7bb112b47538237e84d4f214423","type":"text","conversion_output":true,"text":"assign a new set of drug kit IDs for the pharmacist to label with \"Use Next\" labels. The","text_display":" assign a new set of drug kit IDs for the pharmacist to label with \"Use Next\" labels. The","confidence":1,"confidence_rate":1},{"cnt":[[430,438],[1601,438],[1601,483],[430,483]],"region":{"top_left_x":429,"top_left_y":438,"width":1172,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ef94afdfd814b4fa26f7338b71f189a","type":"text","conversion_output":true,"text":"pharmacist will properly dispose of the pre-mixed IV drug and the matching","text_display":" pharmacist will properly dispose of the pre-mixed IV drug and the matching","confidence":0.53515625,"confidence_rate":0.9921173523213868},{"cnt":[[430,486],[1489,486],[1489,531],[430,531]],"region":{"top_left_x":429,"top_left_y":485,"width":1060,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3db1a8a3899a472ab52c844c37d455af","type":"text","conversion_output":true,"text":"aspirin/aspirin-placebo kit in accordance with institutional guidelines.","text_display":" aspirin/aspirin-placebo kit in accordance with institutional guidelines.","confidence":1,"confidence_rate":1},{"cnt":[[430,576],[1734,576],[1734,621],[430,621]],"region":{"top_left_x":429,"top_left_y":575,"width":1305,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa908279ccf54dc0a31897478ae706a1","type":"text","conversion_output":true,"text":"Prior to the first patient enrolled at a site, a site will register with IWRS as part of site","text_display":"\n\nPrior to the first patient enrolled at a site, a site will register with IWRS as part of site","confidence":1,"confidence_rate":1},{"cnt":[[430,621],[1710,621],[1710,666],[430,666]],"region":{"top_left_x":429,"top_left_y":620,"width":1282,"height":47},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a90ef73ec0844f496a4dc817db83f25","type":"text","conversion_output":true,"text":"activation, which will assign drug kit IDs ahead of time for the first potential patient.","text_display":" activation, which will assign drug kit IDs ahead of time for the first potential patient.","confidence":1,"confidence_rate":1},{"cnt":[[432,670],[1815,670],[1815,713],[432,713]],"region":{"top_left_x":431,"top_left_y":670,"width":1385,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcdf197025d84a16b395a17a002c8ff4","type":"text","conversion_output":true,"text":"Once the first patient is enrolled at a site, the procedure described above will commence.","text_display":" Once the first patient is enrolled at a site, the procedure described above will commence.","confidence":1,"confidence_rate":1},{"cnt":[[425,743],[758,743],[758,797],[425,797]],"region":{"top_left_x":425,"top_left_y":743,"width":334,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46578bc33c26484fb6cdeaf93c7af2e8","type":"section_header","conversion_output":false,"children_ids":["f807ef46c97240698f4b1b6febf94371"],"text":"","text_display":""},{"cnt":[[432,748],[754,748],[754,793],[432,793]],"region":{"top_left_x":431,"top_left_y":747,"width":324,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f807ef46c97240698f4b1b6febf94371","type":"text","conversion_output":true,"parent_id":"46578bc33c26484fb6cdeaf93c7af2e8","text":"Study Unblinding","text_display":"\n\n\\section*{Study Unblinding}","confidence":1,"confidence_rate":1},{"cnt":[[430,799],[1777,799],[1777,844],[430,844]],"region":{"top_left_x":429,"top_left_y":799,"width":1348,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e82d603e8a454b48b8f1cbd41906c227","type":"text","conversion_output":true,"text":"If a clinical situation arises in which the investigator thinks it is necessary to unblind","text_display":"\n\nIf a clinical situation arises in which the investigator thinks it is necessary to unblind","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[430,846],[1760,846],[1760,892],[430,892]],"region":{"top_left_x":429,"top_left_y":846,"width":1331,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f008d9c9b74d47ce800e2b566c887609","type":"text","conversion_output":true,"text":"in the interest of patient safety, the Medical Monitor must be notified immediately to","text_display":" in the interest of patient safety, the Medical Monitor must be notified immediately to","confidence":1,"confidence_rate":1},{"cnt":[[430,894],[1712,894],[1712,941],[430,941]],"region":{"top_left_x":429,"top_left_y":893,"width":1284,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fcb0303d3c08412495da1e5bce842cfe","type":"text","conversion_output":true,"text":"discuss the intended unblinding. Unblinding should occur only in settings where","text_display":" discuss the intended unblinding. Unblinding should occur only in settings where","confidence":1,"confidence_rate":1},{"cnt":[[430,941],[1764,941],[1764,986],[430,986]],"region":{"top_left_x":429,"top_left_y":941,"width":1335,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b972dd9ae6ce4429b3badd04247ad36d","type":"text","conversion_output":true,"text":"identification of the study treatment is critical for treatment decisions. IWRS will be","text_display":" identification of the study treatment is critical for treatment decisions. 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Treatment codes should not be broken except","text_display":" or she must contact the Medical Monitor. Treatment codes should not be broken except","confidence":1,"confidence_rate":1},{"cnt":[[430,1220],[1699,1220],[1699,1265],[430,1265]],"region":{"top_left_x":429,"top_left_y":1220,"width":1271,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3858926b31d457ab3574b3bdec653c5","type":"text","conversion_output":true,"text":"under circumstances deemed necessary by the site investigator. The investigator","text_display":" under circumstances deemed necessary by the site investigator. 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Each kit will contain one bottle, which","text_display":"\n\nAspirin ( 325 mg ) will be packaged for the study. Each kit will contain one bottle, which","confidence":0.79541015625,"confidence_rate":0.9977136439272338},{"cnt":[[430,1375],[1772,1375],[1772,1420],[430,1420]],"region":{"top_left_x":429,"top_left_y":1375,"width":1344,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"069b73a3d86d46929eeb54b1692323b7","type":"text","conversion_output":true,"text":"has 100 tablets labeled for \"clinical trial use only.\" Only one tablet will be administered","text_display":" has 100 tablets labeled for \"clinical trial use only.\" Only one tablet will be administered","confidence":0.9970703125,"confidence_rate":0.9999703642024339},{"cnt":[[430,1422],[1607,1422],[1607,1467],[430,1467]],"region":{"top_left_x":429,"top_left_y":1422,"width":1179,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4ca9f381f52498b8c55a630a98d1b32","type":"text","conversion_output":true,"text":"to the patient, and the remainder of the bottle will be kept at the site for drug","text_display":" to the patient, and the remainder of the bottle will be kept at the site for drug","confidence":1,"confidence_rate":1},{"cnt":[[430,1474],[660,1474],[660,1515],[430,1515]],"region":{"top_left_x":429,"top_left_y":1473,"width":231,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"457c2207c8724398b8be4420ee945c45","type":"text","conversion_output":true,"text":"accountability.","text_display":" accountability.","confidence":1,"confidence_rate":1},{"cnt":[[430,1560],[1790,1560],[1790,1601],[430,1601]],"region":{"top_left_x":429,"top_left_y":1559,"width":1361,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0d751cc20844e859b89e19720d17645","type":"text","conversion_output":true,"text":"Aspirin tablets should be stored at \\(25^{\\circ} C\\) with excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","text_display":"\n\nAspirin tablets should be stored at \\(25^{\\circ} C\\) with excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","confidence":1,"confidence_rate":1},{"cnt":[[425,1633],[952,1633],[952,1687],[425,1687]],"region":{"top_left_x":425,"top_left_y":1632,"width":527,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73b41c3870394cb8b08d64fdf2a7699a","type":"section_header","conversion_output":false,"children_ids":["4bfe309a53ec430baf596910c354acdb"],"text":"","text_display":""},{"cnt":[[430,1637],[947,1637],[947,1682],[430,1682]],"region":{"top_left_x":429,"top_left_y":1637,"width":519,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bfe309a53ec430baf596910c354acdb","type":"text","conversion_output":true,"parent_id":"73b41c3870394cb8b08d64fdf2a7699a","text":"4.3.1.4 Aspirin Placebo","text_display":"\n\n\\subsection*{4.3.1.4 Aspirin Placebo}","confidence":1,"confidence_rate":1},{"cnt":[[430,1691],[1742,1691],[1742,1734],[430,1734]],"region":{"top_left_x":429,"top_left_y":1690,"width":1314,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69f3913fc78f4f8c89816104941157e7","type":"text","conversion_output":true,"text":"Aspirin placebo will be identical in appearance to active aspirin to maintain treatment","text_display":"\n\nAspirin placebo will be identical in appearance to active aspirin to maintain treatment","confidence":1,"confidence_rate":1},{"cnt":[[430,1738],[1794,1738],[1794,1781],[430,1781]],"region":{"top_left_x":429,"top_left_y":1738,"width":1365,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77d41b59bae34794b959244b4dbe2502","type":"text","conversion_output":true,"text":"blinding. Each bottle of aspirin placebo contains 100 tablets labeled for \"clinical trial use","text_display":" blinding. Each bottle of aspirin placebo contains 100 tablets labeled for \"clinical trial use","confidence":1,"confidence_rate":1},{"cnt":[[430,1785],[1798,1785],[1798,1828],[430,1828]],"region":{"top_left_x":429,"top_left_y":1785,"width":1370,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db6f6e7fe202411597e008a670014649","type":"text","conversion_output":true,"text":"only.\" Only one tablet will be administered to the patient, and the remainder of the bottle","text_display":" only.\" Only one tablet will be administered to the patient, and the remainder of the bottle","confidence":1,"confidence_rate":1},{"cnt":[[430,1833],[1132,1833],[1132,1876],[430,1876]],"region":{"top_left_x":429,"top_left_y":1832,"width":704,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d49a05532afb403fbbd0979cd3d87cb7","type":"text","conversion_output":true,"text":"will be kept at the site for drug accountability.","text_display":" will be kept at the site for drug accountability.","confidence":1,"confidence_rate":1},{"cnt":[[432,1921],[1712,1921],[1712,1964],[432,1964]],"region":{"top_left_x":431,"top_left_y":1920,"width":1282,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3954b323e2d64a7f9ddbcd9c919c1af8","type":"text","conversion_output":true,"text":"Placebo tablets should be stored in the same manner as aspirin tablets: \\(25^{\\circ} C\\) with","text_display":"\n\nPlacebo tablets should be stored in the same manner as aspirin tablets: \\(25^{\\circ} C\\) with","confidence":0.9980475902557373,"confidence_rate":0.9999802596071612},{"cnt":[[432,1968],[1094,1968],[1094,2013],[432,2013]],"region":{"top_left_x":431,"top_left_y":1967,"width":663,"height":47},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55908b07ecf94b788de36ed0097987aa","type":"text","conversion_output":true,"text":"excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","text_display":" excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","confidence":1,"confidence_rate":1},{"cnt":[[425,2045],[1412,2045],[1412,2099],[425,2099]],"region":{"top_left_x":425,"top_left_y":2045,"width":987,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e75675981ac4258829edb380748ab1c","type":"section_header","conversion_output":false,"children_ids":["c3a1e147529c4e7b9c2e43c6b230aaf5"],"text":"","text_display":""},{"cnt":[[430,2050],[1407,2050],[1407,2095],[430,2095]],"region":{"top_left_x":429,"top_left_y":2049,"width":979,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3a1e147529c4e7b9c2e43c6b230aaf5","type":"text","conversion_output":true,"parent_id":"5e75675981ac4258829edb380748ab1c","text":"4.3.2 Dosage, Administration, and Compliance","text_display":"\n\n\\subsection*{4.3.2 Dosage, Administration, and Compliance}","confidence":0.99951171875,"confidence_rate":0.9999900326925697},{"cnt":[[425,2097],[836,2097],[836,2151],[425,2151]],"region":{"top_left_x":425,"top_left_y":2096,"width":411,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"361628c9b7804793a9cb64494dcbeea2","type":"section_header","conversion_output":false,"children_ids":["ff37d6ad3241415aaca9b7749a246a67"],"text":"","text_display":""},{"cnt":[[430,2101],[831,2101],[831,2146],[430,2146]],"region":{"top_left_x":429,"top_left_y":2101,"width":403,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff37d6ad3241415aaca9b7749a246a67","type":"text","conversion_output":true,"parent_id":"361628c9b7804793a9cb64494dcbeea2","text":"4.3.2.1 Alteplase","text_display":"\n\n\\subsection*{4.3.2.1 Alteplase}","confidence":1,"confidence_rate":1},{"cnt":[[430,2153],[1768,2153],[1768,2198],[430,2198]],"region":{"top_left_x":429,"top_left_y":2152,"width":1340,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbacabb5750947a38812fdd8aa8ecd0d","type":"text","conversion_output":true,"text":"For AIS, the recommended dose is \\(0.9 mg / kg\\) infused over 60 minutes with \\(10 \\%\\) of the","text_display":"\n\nFor AIS, the recommended dose is \\(0.9 mg / kg\\) infused over 60 minutes with \\(10 \\%\\) of the","confidence":0.99853515625,"confidence_rate":0.9999854860688677},{"cnt":[[430,2200],[1764,2200],[1764,2241],[430,2241]],"region":{"top_left_x":429,"top_left_y":2200,"width":1335,"height":41},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6e0d6b332874a7584fa3da5f9e0039a","type":"text","conversion_output":true,"text":"total dose administered as an initial IV bolus over 1 minute. The total dose should not","text_display":" total dose administered as an initial IV bolus over 1 minute. The total dose should not","confidence":1,"confidence_rate":1},{"cnt":[[430,2247],[666,2247],[666,2292],[430,2292]],"region":{"top_left_x":429,"top_left_y":2247,"width":238,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9533fb9beea347409fca9fc3f273e74c","type":"text","conversion_output":true,"text":"exceed 90 mg .","text_display":" exceed 90 mg .","confidence":1,"confidence_rate":1},{"cnt":[[430,2423],[846,2423],[846,2460],[430,2460]],"region":{"top_left_x":429,"top_left_y":2423,"width":418,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13ac7e1111ac4af79c94755c63b7f47e","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.990257006143338,"confidence_rate":0.9996736943366328},{"cnt":[[430,2462],[849,2462],[849,2499],[430,2499]],"region":{"top_left_x":429,"top_left_y":2462,"width":420,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9de0c114f8404916b0997c06343b7167","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1764,2462],[1818,2462],[1818,2505],[1764,2505]],"region":{"top_left_x":1763,"top_left_y":2462,"width":55,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbb243cb198b4a3997dac4d4ca583de1","type":"page_info","conversion_output":false,"text":"44","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2126cc73e2be40b0b1d11fc012ffae26","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9941508700155737,"confidence_rate":0.9999097532548931},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78b465c50c634f4195de23ccaad77745","type":"page_info","conversion_output":false,"text":"476/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-141","page":141,"lines":[{"cnt":[[432,346],[1775,346],[1775,389],[432,389]],"region":{"top_left_x":431,"top_left_y":345,"width":1344,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3496f6aca40a48bd85b2ff50ac71f924","type":"text","conversion_output":true,"text":"Because alteplase and alteplase placebo contain no antibacterial preservatives, \\(50- mg\\)","text_display":"\n\nBecause alteplase and alteplase placebo contain no antibacterial preservatives, \\(50- mg\\)","confidence":0.9956090442137793,"confidence_rate":0.99995216827065},{"cnt":[[430,391],[1790,391],[1790,436],[430,436]],"region":{"top_left_x":429,"top_left_y":391,"width":1361,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bfb93a8d25a4e6db20c993b3c440ffc","type":"text","conversion_output":true,"text":"vials should be reconstituted immediately before use by adding 50 mL of SWFI, USP, to","text_display":" vials should be reconstituted immediately before use by adding 50 mL of SWFI, USP, to","confidence":1,"confidence_rate":1},{"cnt":[[430,438],[1790,438],[1790,483],[430,483]],"region":{"top_left_x":429,"top_left_y":438,"width":1361,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"706beaef17f1434582b0675eb9b64b38","type":"text","conversion_output":true,"text":"the vial; this yields a concentration of \\(1 mg / mL\\). Using aseptic technique, direct the flow","text_display":" the vial; this yields a concentration of \\(1 mg / mL\\). Using aseptic technique, direct the flow","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[430,486],[1708,486],[1708,531],[430,531]],"region":{"top_left_x":429,"top_left_y":485,"width":1280,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d83cfbba5c4468c858e4ee6be44fe41","type":"text","conversion_output":true,"text":"of SWFI directly into the lyophilized cake of study drug. It is recommended that an","text_display":" of SWFI directly into the lyophilized cake of study drug. It is recommended that an","confidence":1,"confidence_rate":1},{"cnt":[[432,533],[1757,533],[1757,578],[432,578]],"region":{"top_left_x":431,"top_left_y":532,"width":1327,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14d86a6c5ae24343b253771cc8a1a461","type":"text","conversion_output":true,"text":"\\(18-\\) gauge needle be used for the reconstitution of the \\(50- mg\\) vial. Once reconstituted,","text_display":" \\(18-\\) gauge needle be used for the reconstitution of the \\(50- mg\\) vial. Once reconstituted,","confidence":0.9561878945678473,"confidence_rate":0.9995334334301353},{"cnt":[[430,580],[1766,580],[1766,625],[430,625]],"region":{"top_left_x":429,"top_left_y":580,"width":1338,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a5e4e18bf514d6fb61ecc56e3b86d74","type":"text","conversion_output":true,"text":"gently swirl the vial. Do not shake. Slight foaming upon reconstitution is not unusual;","text_display":" gently swirl the vial. Do not shake. Slight foaming upon reconstitution is not unusual;","confidence":1,"confidence_rate":1},{"cnt":[[430,627],[1745,627],[1745,672],[430,672]],"region":{"top_left_x":429,"top_left_y":627,"width":1316,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bb52bc8d4114d03b45374ab42a8d00a","type":"text","conversion_output":true,"text":"allowing the vial to stand undisturbed for several minutes is usually sufficient to allow","text_display":" allowing the vial to stand undisturbed for several minutes is usually sufficient to allow","confidence":1,"confidence_rate":1},{"cnt":[[430,677],[1755,677],[1755,724],[430,724]],"region":{"top_left_x":429,"top_left_y":676,"width":1327,"height":49},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e2e1d615767400a93ae5d538b1528a4","type":"text","conversion_output":true,"text":"dissipation of any large bubbles. Before further dilution or administration, the product","text_display":" dissipation of any large bubbles. Before further dilution or administration, the product","confidence":1,"confidence_rate":1},{"cnt":[[430,726],[1760,726],[1760,769],[430,769]],"region":{"top_left_x":429,"top_left_y":726,"width":1331,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6769c0b437394f16bb4f8b2f50b68e60","type":"text","conversion_output":true,"text":"should be visually inspected for particulate matter and discoloration. If a precipitate is","text_display":" should be visually inspected for particulate matter and discoloration. If a precipitate is","confidence":1,"confidence_rate":1},{"cnt":[[430,773],[1021,773],[1021,814],[430,814]],"region":{"top_left_x":429,"top_left_y":773,"width":592,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85a3dd858d384de5ba2903e4f7d105be","type":"text","conversion_output":true,"text":"seen, the product should not be used.","text_display":" seen, the product should not be used.","confidence":1,"confidence_rate":1},{"cnt":[[430,855],[1747,855],[1747,900],[430,900]],"region":{"top_left_x":429,"top_left_y":855,"width":1318,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f924b3a7dd14eca96050de6d05d3cdf","type":"text","conversion_output":true,"text":"After reconstitution, alteplase should be administered at \\(1 mg / mL\\). As an alternative,","text_display":"\n\nAfter reconstitution, alteplase should be administered at \\(1 mg / mL\\). As an alternative,","confidence":1,"confidence_rate":1},{"cnt":[[430,904],[1772,904],[1772,952],[430,952]],"region":{"top_left_x":429,"top_left_y":904,"width":1344,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f1d272d7ae8432ea77d0fceff8fd7a7","type":"text","conversion_output":true,"text":"the reconstituted solution may be diluted further immediately before administration in","text_display":" the reconstituted solution may be diluted further immediately before administration in","confidence":0.99365234375,"confidence_rate":0.9999300256540034},{"cnt":[[430,954],[1725,954],[1725,999],[430,999]],"region":{"top_left_x":429,"top_left_y":953,"width":1297,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04a6740f81434a2f8329df8400baa371","type":"text","conversion_output":true,"text":"an equal volume of \\(0.9 \\%\\) sodium chloride injection, USP, or \\(5 \\%\\) dextrose injection,","text_display":" an equal volume of \\(0.9 \\%\\) sodium chloride injection, USP, or \\(5 \\%\\) dextrose injection,","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[432,1001],[1635,1001],[1635,1046],[432,1046]],"region":{"top_left_x":431,"top_left_y":1001,"width":1204,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d64b084d82f413895b6cc75e854ddde","type":"text","conversion_output":true,"text":"USP, to yield a concentration of \\(0.5 mg / mL\\). The osmolality of this solution is","text_display":" USP, to yield a concentration of \\(0.5 mg / mL\\). The osmolality of this solution is","confidence":1,"confidence_rate":1},{"cnt":[[430,1048],[1755,1048],[1755,1094],[430,1094]],"region":{"top_left_x":429,"top_left_y":1048,"width":1327,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0a1f696f6c74bb8be4089016b11c329","type":"text","conversion_output":true,"text":"approximately \\(215 mOsm / kg\\). Polyvinyl chloride bags, glass bottles, or polypropylene","text_display":" approximately \\(215 mOsm / kg\\). Polyvinyl chloride bags, glass bottles, or polypropylene","confidence":0.998046875,"confidence_rate":0.9999798452048033},{"cnt":[[430,1096],[1800,1096],[1800,1141],[430,1141]],"region":{"top_left_x":429,"top_left_y":1095,"width":1372,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d696e9e9b2e24146bbef0fb7ac1c7497","type":"text","conversion_output":true,"text":"syringes are acceptable. Do not use filter needles for infusion. Alteplase is stable for up","text_display":" syringes are acceptable. Do not use filter needles for infusion. Alteplase is stable for up","confidence":1,"confidence_rate":1},{"cnt":[[430,1143],[1803,1143],[1803,1188],[430,1188]],"region":{"top_left_x":429,"top_left_y":1142,"width":1374,"height":47},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c608676ba284c68b985c4bb9aceba1e","type":"text","conversion_output":true,"text":"to 8 hours in these solutions at room temperature. Exposure to light has no effect on the","text_display":" to 8 hours in these solutions at room temperature. Exposure to light has no effect on the","confidence":0.998046875,"confidence_rate":0.9999798452048033},{"cnt":[[430,1190],[1803,1190],[1803,1240],[430,1240]],"region":{"top_left_x":429,"top_left_y":1190,"width":1374,"height":50},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a17e2506e25b48e2a06776617f557eae","type":"text","conversion_output":true,"text":"stability of these solutions. Excessive agitation during dilution should be avoided; mixing","text_display":" stability of these solutions. 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The investigator will maintain a screening log of all","text_display":" all eligibility criteria before treatment. 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The NIHSS will","text_display":"\n\nA partial neurological examination is to be performed for each patient. The NIHSS will","confidence":1,"confidence_rate":1},{"cnt":[[430,2228],[1652,2228],[1652,2275],[430,2275]],"region":{"top_left_x":429,"top_left_y":2227,"width":1224,"height":49},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e67c1e4d6bc041ebb136d32c355a5168","type":"text","conversion_output":true,"text":"be a component of this neurological examination and will be performed only by","text_display":" be a component of this neurological examination and will be performed only by","confidence":0.99951171875,"confidence_rate":0.9999940439141021},{"cnt":[[430,2277],[1674,2277],[1674,2322],[430,2322]],"region":{"top_left_x":429,"top_left_y":2277,"width":1245,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"999f3d1c60e745088e7d7357a16b2761","type":"text","conversion_output":true,"text":"practitioners who are certified to perform an NIHSS assessment. 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The purpose of this is to evaluate for ICH in the","text_display":" initiation (bolus) of study drug infusion. The purpose of this is to evaluate for ICH in the","confidence":1,"confidence_rate":1},{"cnt":[[430,2127],[1764,2127],[1764,2172],[430,2172]],"region":{"top_left_x":429,"top_left_y":2126,"width":1335,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54388bfabaa244dd814aea52e78c162f","type":"text","conversion_output":true,"text":"patient. An NIHSS should be performed at the time this CT scan or MRI is performed,","text_display":" patient. 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The","text_display":" more fully characterize the clinical profile of alteplase in this patient population. The","confidence":1,"confidence_rate":1},{"cnt":[[432,1048],[1751,1048],[1751,1094],[432,1094]],"region":{"top_left_x":431,"top_left_y":1048,"width":1320,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bf787165bbc44d18206d9c7faf0432d","type":"text","conversion_output":true,"text":"PRO questionnaires will be distributed by the investigator staff and completed in their","text_display":" PRO questionnaires will be distributed by the investigator staff and completed in their","confidence":1,"confidence_rate":1},{"cnt":[[430,1096],[1055,1096],[1055,1141],[430,1141]],"region":{"top_left_x":429,"top_left_y":1095,"width":626,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abf2d19f7ba94761ab80de3f5bf6b360","type":"text","conversion_output":true,"text":"entirety by the patient or their surrogate.","text_display":" entirety by the patient or their surrogate.","confidence":1,"confidence_rate":1},{"cnt":[[430,1182],[1772,1182],[1772,1227],[430,1227]],"region":{"top_left_x":429,"top_left_y":1181,"width":1344,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9468dd13daca44c88bfcb6099825d99e","type":"text","conversion_output":true,"text":"This study will assess the impact of alteplase treatment on health-related quality of life,","text_display":"\n\nThis study will assess the impact of alteplase treatment on health-related quality of life,","confidence":1,"confidence_rate":1},{"cnt":[[430,1229],[1439,1229],[1439,1274],[430,1274]],"region":{"top_left_x":429,"top_left_y":1228,"width":1011,"height":47},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a7fdbd453e240619c90ebb4f00ddd29","type":"text","conversion_output":true,"text":"physical function, daily functioning, and symptoms of depression.","text_display":" physical function, daily functioning, and symptoms of depression.","confidence":1,"confidence_rate":1},{"cnt":[[430,1317],[1807,1317],[1807,1362],[430,1362]],"region":{"top_left_x":429,"top_left_y":1316,"width":1378,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bdfccbf9aa644e6a70405b58d35a9dc","type":"text","conversion_output":true,"text":"Health-related quality of life will be assessed using the EQ-5D (Appendix 4). 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The","confidence":1,"confidence_rate":1},{"cnt":[[430,2020],[1592,2020],[1592,2065],[430,2065]],"region":{"top_left_x":429,"top_left_y":2019,"width":1163,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a897d8b783da499a815092ff8886bd60","type":"text","conversion_output":true,"text":"principal adverse reactions to alteplase are bleeding and allergic reactions.","text_display":" principal adverse reactions to alteplase are bleeding and allergic reactions.","confidence":1,"confidence_rate":1},{"cnt":[[430,2423],[846,2423],[846,2460],[430,2460]],"region":{"top_left_x":429,"top_left_y":2423,"width":418,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59682987748f4ddcb1d2fbd74d4daafa","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9873532515868533,"confidence_rate":0.9995758433386206},{"cnt":[[430,2462],[849,2462],[849,2499],[430,2499]],"region":{"top_left_x":429,"top_left_y":2462,"width":420,"height":37},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a519162c22534f078d990c2c69f9cc90","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1766,2462],[1818,2462],[1818,2505],[1766,2505]],"region":{"top_left_x":1766,"top_left_y":2462,"width":52,"height":44},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fdede418caa49dfaa8304423574eb66","type":"page_info","conversion_output":false,"text":"53","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95f723834ac749ca82fec748a5de91b5","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922077439341592,"confidence_rate":0.9998796568674472},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afe3395be3084787bd50203181f5f672","type":"page_info","conversion_output":false,"text":"485/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-150","page":150,"lines":[{"cnt":[[430,335],[965,335],[965,389],[430,389]],"region":{"top_left_x":429,"top_left_y":335,"width":536,"height":54},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14c5cbd2c9d4423eba89a35b1cc5a638","type":"section_header","conversion_output":false,"children_ids":["354295a9e8b246d9a5ba9484302a74c1"],"text":"","text_display":""},{"cnt":[[434,339],[960,339],[960,385],[434,385]],"region":{"top_left_x":433,"top_left_y":339,"width":528,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"354295a9e8b246d9a5ba9484302a74c1","type":"text","conversion_output":true,"parent_id":"14c5cbd2c9d4423eba89a35b1cc5a638","text":"5.1.1 Risk of Bleeding","text_display":"\n\n\\subsection*{5.1.1 Risk of Bleeding}","confidence":0.9863345623016357,"confidence_rate":0.9994905124531074},{"cnt":[[434,400],[1790,400],[1790,440],[434,440]],"region":{"top_left_x":433,"top_left_y":399,"width":1357,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8807884503e4f128e45bfef81613f92","type":"text","conversion_output":true,"text":"Bleeding is the most frequent adverse reaction associated with alteplase in all approved","text_display":"\n\nBleeding is the most frequent adverse reaction associated with alteplase in all approved","confidence":1,"confidence_rate":1},{"cnt":[[432,447],[1747,447],[1747,488],[432,488]],"region":{"top_left_x":431,"top_left_y":446,"width":1316,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01e8d5eca1dc406594c73e45c4373c78","type":"text","conversion_output":true,"text":"indications, including AIS. This may be either superficial from punctures or damaged","text_display":" indications, including AIS. This may be either superficial from punctures or damaged","confidence":1,"confidence_rate":1},{"cnt":[[434,494],[1721,494],[1721,535],[434,535]],"region":{"top_left_x":433,"top_left_y":494,"width":1288,"height":41},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebe1570b89654bbc92477ab7dd9c8aa3","type":"text","conversion_output":true,"text":"blood vessels or internal bleeding at any site or body cavity. Bleeding may result in","text_display":" blood vessels or internal bleeding at any site or body cavity. Bleeding may result in","confidence":1,"confidence_rate":1},{"cnt":[[432,541],[1308,541],[1308,587],[432,587]],"region":{"top_left_x":431,"top_left_y":541,"width":878,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06a54ea6da1e4fa180b85326a4c63499","type":"text","conversion_output":true,"text":"life-threatening situations, permanent disability, or death.","text_display":" life-threatening situations, permanent disability, or death.","confidence":1,"confidence_rate":1},{"cnt":[[434,604],[1772,604],[1772,645],[434,645]],"region":{"top_left_x":433,"top_left_y":603,"width":1340,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3846c61f1524642be1353a4a7c19635","type":"text","conversion_output":true,"text":"- The incidence of ICH, especially symptomatic ICH, in patients with AIS is higher in","text_display":"\n- The incidence of ICH, especially symptomatic ICH, in patients with AIS is higher in","confidence":1,"confidence_rate":1},{"cnt":[[501,649],[1738,649],[1738,690],[501,690]],"region":{"top_left_x":500,"top_left_y":648,"width":1239,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d7c30549e8947b7a7e4f77ae57f09ff","type":"text","conversion_output":true,"text":"alteplase-treated patients than placebo-treated patients in published studies (for","text_display":" alteplase-treated patients than placebo-treated patients in published studies (for","confidence":1,"confidence_rate":1},{"cnt":[[501,692],[1205,692],[1205,733],[501,733]],"region":{"top_left_x":500,"top_left_y":691,"width":706,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f75b36aa6334876b28f57513c85368e","type":"text","conversion_output":true,"text":"detailed information, see the alteplase USPI).","text_display":" detailed information, see the alteplase USPI).","confidence":1,"confidence_rate":1},{"cnt":[[430,761],[889,761],[889,810],[430,810]],"region":{"top_left_x":429,"top_left_y":760,"width":461,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"666990095ef44c4f9533a2c91b3b9af3","type":"section_header","conversion_output":false,"children_ids":["b1f9a0ce815d4981b744386feb8871fc"],"text":"","text_display":""},{"cnt":[[434,765],[887,765],[887,810],[434,810]],"region":{"top_left_x":433,"top_left_y":764,"width":455,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1f9a0ce815d4981b744386feb8871fc","type":"text","conversion_output":true,"parent_id":"666990095ef44c4f9533a2c91b3b9af3","text":"Management of Bleeding","text_display":"\n\n\\section*{Management of Bleeding}","confidence":1,"confidence_rate":1},{"cnt":[[434,819],[1704,819],[1704,862],[434,862]],"region":{"top_left_x":433,"top_left_y":818,"width":1271,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cf9290e6e034e4d88aba737d817160c","type":"text","conversion_output":true,"text":"Patients will be excluded for the presence of conditions related to risks of bleeding","text_display":"\n\nPatients will be excluded for the presence of conditions related to risks of bleeding","confidence":1,"confidence_rate":1},{"cnt":[[434,866],[1708,866],[1708,907],[434,907]],"region":{"top_left_x":433,"top_left_y":865,"width":1276,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e39e2842cd3b4a549b7dc46b0f3686ee","type":"text","conversion_output":true,"text":"(as outlined in Section 4.1.2, Exclusion Criteria). A non-contrast cranial CT or MRI","text_display":" (as outlined in Section 4.1.2, Exclusion Criteria). A non-contrast cranial CT or MRI","confidence":1,"confidence_rate":1},{"cnt":[[434,913],[1764,913],[1764,956],[434,956]],"region":{"top_left_x":433,"top_left_y":913,"width":1331,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b44e4326973f4c74944e45c423b3040b","type":"text","conversion_output":true,"text":"(including either SW or GRE to detect ICH) should be performed at baseline to ensure","text_display":" (including either SW or GRE to detect ICH) should be performed at baseline to ensure","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[432,962],[1680,962],[1680,1003],[432,1003]],"region":{"top_left_x":431,"top_left_y":962,"width":1250,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d53a56b6176c4b2ab1d7a3b361de41ae","type":"text","conversion_output":true,"text":"that the patient does not have evidence of ICH prior to study drug administration.","text_display":" that the patient does not have evidence of ICH prior to study drug administration.","confidence":1,"confidence_rate":1},{"cnt":[[434,1048],[1721,1048],[1721,1089],[434,1089]],"region":{"top_left_x":433,"top_left_y":1048,"width":1288,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d67d48afa3b94a13913912a884e3fedd","type":"text","conversion_output":true,"text":"Fibrin, which is part of the hemostatic plug formed at needle puncture sites, may be","text_display":"\n\nFibrin, which is part of the hemostatic plug formed at needle puncture sites, may be","confidence":1,"confidence_rate":1},{"cnt":[[434,1096],[1798,1096],[1798,1137],[434,1137]],"region":{"top_left_x":433,"top_left_y":1095,"width":1366,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fd845057bc04f01921e87a654337dd2","type":"text","conversion_output":true,"text":"lysed during alteplase therapy. Therefore, alteplase therapy requires careful attention to","text_display":" lysed during alteplase therapy. Therefore, alteplase therapy requires careful attention to","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[434,1143],[1794,1143],[1794,1184],[434,1184]],"region":{"top_left_x":433,"top_left_y":1142,"width":1361,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ff34dfcbfa94f399fb065aa80981ec9","type":"text","conversion_output":true,"text":"potential bleeding sites, e.g., catheter-insertion sites and arterial-puncture sites. Arterial","text_display":" potential bleeding sites, e.g., catheter-insertion sites and arterial-puncture sites. Arterial","confidence":1,"confidence_rate":1},{"cnt":[[434,1190],[1708,1190],[1708,1231],[434,1231]],"region":{"top_left_x":433,"top_left_y":1190,"width":1276,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffa7409aa691413ab57b88d6ed8a4da0","type":"text","conversion_output":true,"text":"and venous punctures should be minimized. Non-compressible arterial, as well as","text_display":" and venous punctures should be minimized. Non-compressible arterial, as well as","confidence":1,"confidence_rate":1},{"cnt":[[434,1238],[1682,1238],[1682,1278],[434,1278]],"region":{"top_left_x":433,"top_left_y":1237,"width":1250,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0b75622af134c098f11fb2ac4f3f840","type":"text","conversion_output":true,"text":"internal jugular and subclavian venous punctures, should be avoided to minimize","text_display":" internal jugular and subclavian venous punctures, should be avoided to minimize","confidence":1,"confidence_rate":1},{"cnt":[[434,1285],[1788,1285],[1788,1328],[434,1328]],"region":{"top_left_x":433,"top_left_y":1284,"width":1355,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f7672cefb224a1da44742e035b8695e","type":"text","conversion_output":true,"text":"bleeding from non-compressible sites. In the event of serious bleeding (not controllable","text_display":" bleeding from non-compressible sites. In the event of serious bleeding (not controllable","confidence":1,"confidence_rate":1},{"cnt":[[432,1332],[1665,1332],[1665,1377],[432,1377]],"region":{"top_left_x":431,"top_left_y":1332,"width":1235,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fcbc21c4d0e2475da378ce48214eef4b","type":"text","conversion_output":true,"text":"by local pressure) or occurring in a critical location (intracranial, gastrointestinal,","text_display":" by local pressure) or occurring in a critical location (intracranial, gastrointestinal,","confidence":1,"confidence_rate":1},{"cnt":[[432,1381],[1648,1381],[1648,1422],[432,1422]],"region":{"top_left_x":431,"top_left_y":1381,"width":1217,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51c335d2000942399519282bb0bf212e","type":"text","conversion_output":true,"text":"retroperitoneal, or pericardial), study drug should be discontinued immediately.","text_display":" retroperitoneal, or pericardial), study drug should be discontinued immediately.","confidence":0.99853515625,"confidence_rate":0.9999827540583306},{"cnt":[[434,1429],[1815,1429],[1815,1470],[434,1470]],"region":{"top_left_x":433,"top_left_y":1428,"width":1383,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"261f058aa8e944a794a2bc130f1a5a12","type":"text","conversion_output":true,"text":"Supportive care and medical management of AEs are at the discretion of the investigator.","text_display":" Supportive care and medical management of AEs are at the discretion of the investigator.","confidence":1,"confidence_rate":1},{"cnt":[[430,1508],[1132,1508],[1132,1555],[430,1555]],"region":{"top_left_x":429,"top_left_y":1508,"width":704,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e24dd29d5bbe4cd7ad2627b985216181","type":"section_header","conversion_output":false,"children_ids":["7c6a17ab6a7745e9adb579e152844cee"],"text":"","text_display":""},{"cnt":[[434,1508],[1130,1508],[1130,1553],[434,1553]],"region":{"top_left_x":433,"top_left_y":1508,"width":698,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c6a17ab6a7745e9adb579e152844cee","type":"text","conversion_output":true,"parent_id":"e24dd29d5bbe4cd7ad2627b985216181","text":"5.1.2 Risk of Allergic Reactions","text_display":"\n\n\\subsection*{5.1.2 Risk of Allergic Reactions}","confidence":0.9970703125,"confidence_rate":0.9999207061862236},{"cnt":[[432,1568],[1674,1568],[1674,1609],[432,1609]],"region":{"top_left_x":431,"top_left_y":1568,"width":1243,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cade655c4444dafa6c10ef613a528a3","type":"text","conversion_output":true,"text":"Allergic-type reactions, e.g., anaphylactoid reaction, laryngeal edema, orolingual","text_display":"\n\nAllergic-type reactions, e.g., anaphylactoid reaction, laryngeal edema, orolingual","confidence":1,"confidence_rate":1},{"cnt":[[432,1618],[1785,1618],[1785,1659],[432,1659]],"region":{"top_left_x":431,"top_left_y":1617,"width":1355,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1577a54371b4a54bc604b8fb24f653c","type":"text","conversion_output":true,"text":"angioedema, rash, and urticaria, have been reported. When such reactions occur, they","text_display":" angioedema, rash, and urticaria, have been reported. When such reactions occur, they","confidence":1,"confidence_rate":1},{"cnt":[[434,1667],[1059,1667],[1059,1708],[434,1708]],"region":{"top_left_x":433,"top_left_y":1667,"width":627,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca65442acd1b45c09d85486b072419b6","type":"text","conversion_output":true,"text":"usually respond to conventional therapy.","text_display":" usually respond to conventional therapy.","confidence":1,"confidence_rate":1},{"cnt":[[432,1753],[1755,1753],[1755,1794],[432,1794]],"region":{"top_left_x":431,"top_left_y":1753,"width":1325,"height":41},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39e31fa59ea446c8a1d14db95c9a1c8f","type":"text","conversion_output":true,"text":"There have been postmarketing reports of orolingual angioedema associated with the","text_display":"\n\nThere have been postmarketing reports of orolingual angioedema associated with the","confidence":1,"confidence_rate":1},{"cnt":[[434,1800],[1760,1800],[1760,1841],[434,1841]],"region":{"top_left_x":433,"top_left_y":1800,"width":1327,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fb9088e8bbb44b1963b34f227d0643b","type":"text","conversion_output":true,"text":"use of alteplase. Most were patients treated for AIS. Many of these patients received","text_display":" use of alteplase. Most were patients treated for AIS. Many of these patients received","confidence":1,"confidence_rate":1},{"cnt":[[434,1848],[1742,1848],[1742,1888],[434,1888]],"region":{"top_left_x":433,"top_left_y":1847,"width":1310,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa2e9ec2c72444078d6585e14ef852dd","type":"text","conversion_output":true,"text":"concomitant angiotensin-converting enzyme inhibitors, and most cases resolved with","text_display":" concomitant angiotensin-converting enzyme inhibitors, and most cases resolved with","confidence":0.99853515625,"confidence_rate":0.9999831505134198},{"cnt":[[434,1895],[711,1895],[711,1936],[434,1936]],"region":{"top_left_x":433,"top_left_y":1894,"width":279,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6872ff02acda4308b7344725458f1c84","type":"text","conversion_output":true,"text":"prompt treatment.","text_display":" prompt 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AESIs for this study include the following:","text_display":" reporting instructions). 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13)","confidence":1,"confidence_rate":1},{"cnt":[[430,1199],[1687,1199],[1687,1248],[430,1248]],"region":{"top_left_x":429,"top_left_y":1198,"width":1258,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a6ea518b199474d8dcc4d3ceab20f35","type":"text","conversion_output":true,"text":"- Stroke recurrence: report if the \\(A E\\) resulted in a substantial disruption of a","text_display":"\n- Stroke recurrence: report if the \\(A E\\) resulted in a substantial disruption of a","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[494,1246],[1661,1246],[1661,1291],[494,1291]],"region":{"top_left_x":494,"top_left_y":1246,"width":1167,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed1b60344271488996e103d99a7bb561","type":"text","conversion_output":true,"text":"person's ability to conduct normal life functions (i.e., the AE resulted in a","text_display":" person's ability to 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considering especially the effects of dose reduction,","confidence":1,"confidence_rate":1},{"cnt":[[498,387],[1669,387],[1669,432],[498,432]],"region":{"top_left_x":498,"top_left_y":386,"width":1172,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f95b643b20a46bcba7317ac41b21cc6","type":"text","conversion_output":true,"text":"discontinuation of study drug, or reintroduction of study drug (as applicable)","text_display":" discontinuation of study drug, or reintroduction of study drug (as applicable)","confidence":1,"confidence_rate":1},{"cnt":[[430,447],[1689,447],[1689,492],[430,492]],"region":{"top_left_x":429,"top_left_y":446,"width":1260,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe16bdbda7e4437697b09a07e12401ee","type":"text","conversion_output":true,"text":"- Known association of the event with the study drug or with similar treatments","text_display":"\n- Known association of the event with the study drug or with similar treatments","confidence":1,"confidence_rate":1},{"cnt":[[430,507],[1442,507],[1442,552],[430,552]],"region":{"top_left_x":429,"top_left_y":507,"width":1013,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afeceeccd9df4bd2aef307f97ef87c5d","type":"text","conversion_output":true,"text":"- Known association of the event with the disease under study","text_display":"\n- Known association of the event with the disease under study","confidence":1,"confidence_rate":1},{"cnt":[[430,567],[1768,567],[1768,610],[430,610]],"region":{"top_left_x":429,"top_left_y":567,"width":1340,"height":44},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f420eace7fa48a79616a9dca2c84b3b","type":"text","conversion_output":true,"text":"- Presence of risk factors in the patient or use of concomitant medications known to","text_display":"\n- Presence of risk factors in the patient or use of concomitant medications known to","confidence":1,"confidence_rate":1},{"cnt":[[498,610],[1074,610],[1074,651],[498,651]],"region":{"top_left_x":498,"top_left_y":610,"width":577,"height":41},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b169f29ce75e417480327bf4bd0f808f","type":"text","conversion_output":true,"text":"increase the occurrence of the event","text_display":" increase the occurrence of the event","confidence":1,"confidence_rate":1},{"cnt":[[430,672],[1783,672],[1783,711],[430,711]],"region":{"top_left_x":429,"top_left_y":672,"width":1355,"height":40},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e52a07cfcf62445fb7a607c537ed8491","type":"text","conversion_output":true,"text":"- Presence of non-treatment-related factors that are known to be associated with the","text_display":"\n- Presence of non-treatment-related factors that are known to be associated with the","confidence":1,"confidence_rate":1},{"cnt":[[498,718],[874,718],[874,754],[498,754]],"region":{"top_left_x":498,"top_left_y":717,"width":377,"height":38},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0a230cedb96444eabc48d6514b3b857","type":"text","conversion_output":true,"text":"occurrence of the event","text_display":" occurrence of the event","confidence":0.966796875,"confidence_rate":0.998794767502824},{"cnt":[[425,793],[1139,793],[1139,844],[425,844]],"region":{"top_left_x":425,"top_left_y":792,"width":714,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36afc05ebb0040aba5a4025a55df9879","type":"section_header","conversion_output":false,"children_ids":["061b7b76f50b4a73834e550a9bbb9eac"],"text":"","text_display":""},{"cnt":[[430,799],[1137,799],[1137,838],[430,838]],"region":{"top_left_x":429,"top_left_y":799,"width":708,"height":39},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"061b7b76f50b4a73834e550a9bbb9eac","type":"text","conversion_output":true,"parent_id":"36afc05ebb0040aba5a4025a55df9879","text":"Table 5 Causal Attribution Guidance","text_display":"\n\n\\section*{Table 5 Causal Attribution Guidance}","confidence":1,"confidence_rate":1},{"cnt":[[449,877],[1781,877],[1781,917],[449,917]],"region":{"top_left_x":449,"top_left_y":876,"width":1333,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8376b34f85884597b259fed4c7bf65fd","type":"text","conversion_output":true,"text":"Is the adverse event suspected to be caused by the study drug on the basis of facts, evidence,","text_display":"\n\nIs the adverse event suspected to be caused by the study drug on the basis of facts, evidence,","confidence":1,"confidence_rate":1},{"cnt":[[447,915],[1137,915],[1137,956],[447,956]],"region":{"top_left_x":446,"top_left_y":915,"width":691,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9df3677a34634b21ad5491f380a818c9","type":"text","conversion_output":true,"text":"science-based rationales, and clinical judgment?","text_display":" science-based rationales, and clinical judgment?","confidence":1,"confidence_rate":1},{"cnt":[[447,971],[1777,971],[1777,1012],[447,1012]],"region":{"top_left_x":446,"top_left_y":971,"width":1331,"height":41},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3709ab3700db4a08998ed9df1e8a2774","type":"text","conversion_output":true,"text":"YES There is a plausible temporal relationship between the onset of the adverse event and","text_display":"\n\nYES There is a plausible temporal relationship between the onset of the adverse event and","confidence":1,"confidence_rate":1},{"cnt":[[563,1010],[1781,1010],[1781,1051],[563,1051]],"region":{"top_left_x":562,"top_left_y":1009,"width":1220,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0872940384e4c9e82230414c81d7bbc","type":"text","conversion_output":true,"text":"administration of the study drug, and the adverse event cannot be readily explained by","text_display":" administration of the study drug, and the adverse event cannot be readily explained by","confidence":1,"confidence_rate":1},{"cnt":[[563,1046],[1723,1046],[1723,1085],[563,1085]],"region":{"top_left_x":562,"top_left_y":1046,"width":1162,"height":39},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42b0c661d15c4e3281a0d0a2715bab76","type":"text","conversion_output":true,"text":"the patient's clinical state, intercurrent illness, or concomitant therapies; and/or the","text_display":" the patient's clinical state, intercurrent illness, or concomitant therapies; and/or the","confidence":0.98779296875,"confidence_rate":0.9998679426021561},{"cnt":[[563,1085],[1691,1085],[1691,1124],[563,1124]],"region":{"top_left_x":562,"top_left_y":1084,"width":1129,"height":40},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b365e9fcf24047d69d795460afd0ac77","type":"text","conversion_output":true,"text":"adverse event follows a known pattern of response to the study drug; and/or the","text_display":" adverse event follows a known pattern of response to the study drug; and/or the","confidence":1,"confidence_rate":1},{"cnt":[[563,1121],[1695,1121],[1695,1162],[563,1162]],"region":{"top_left_x":562,"top_left_y":1121,"width":1134,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ca8313495fa4b59b8f108d3784f5b8d","type":"text","conversion_output":true,"text":"adverse event abates or resolves upon discontinuation of the study drug or dose","text_display":" adverse event abates or resolves upon discontinuation of the study drug or dose","confidence":0.9990234375,"confidence_rate":0.9999883686432659},{"cnt":[[563,1160],[1377,1160],[1377,1201],[563,1201]],"region":{"top_left_x":562,"top_left_y":1160,"width":816,"height":41},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4249be289e564c18a2c296c1a65d59e7","type":"text","conversion_output":true,"text":"reduction and, if applicable, reappears upon re-challenge.","text_display":" reduction and, if applicable, reappears upon re-challenge.","confidence":1,"confidence_rate":1},{"cnt":[[449,1214],[1738,1214],[1738,1255],[449,1255]],"region":{"top_left_x":449,"top_left_y":1213,"width":1290,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fef4a8b10bb54106a87fc42895148600","type":"text","conversion_output":true,"text":"NO Adverse events will be considered related, unless they fulfill the criteria as specified","text_display":"\nNO Adverse events will be considered related, unless they fulfill the criteria as specified","confidence":1,"confidence_rate":1},{"cnt":[[563,1250],[662,1250],[662,1287],[563,1287]],"region":{"top_left_x":562,"top_left_y":1250,"width":100,"height":37},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d72367b37cc1490d805464d700d9f669","type":"text","conversion_output":true,"text":"below.","text_display":" below.","confidence":1,"confidence_rate":1},{"cnt":[[563,1298],[1695,1298],[1695,1338],[563,1338]],"region":{"top_left_x":562,"top_left_y":1297,"width":1134,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b22ff2e3fd28434a94d57c14b5cf8cde","type":"text","conversion_output":true,"text":"Evidence exists that the adverse event has an etiology other than the study drug","text_display":"\nEvidence exists that the adverse event has an etiology other than the study drug","confidence":1,"confidence_rate":1},{"cnt":[[563,1336],[1622,1336],[1622,1377],[563,1377]],"region":{"top_left_x":562,"top_left_y":1336,"width":1061,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8498c1694f0748a4a0744b0f141ad844","type":"text","conversion_output":true,"text":"(e.g., preexisting medical condition, underlying disease, intercurrent illness,","text_display":" (e.g., preexisting medical condition, underlying disease, intercurrent illness,","confidence":1,"confidence_rate":1},{"cnt":[[563,1375],[1691,1375],[1691,1416],[563,1416]],"region":{"top_left_x":562,"top_left_y":1375,"width":1129,"height":41},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0702be7eeccd46c5bbbdb17d71953c68","type":"text","conversion_output":true,"text":"or concomitant medication); and/or the adverse event has no plausible temporal","text_display":" or concomitant medication); and/or the adverse event has no plausible temporal","confidence":1,"confidence_rate":1},{"cnt":[[563,1414],[1738,1414],[1738,1454],[563,1454]],"region":{"top_left_x":562,"top_left_y":1413,"width":1177,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44c3904148af4af2ac1e60fcdca2db7c","type":"text","conversion_output":true,"text":"relationship to administration of the study drug (e.g., cancer diagnosed 2 days after","text_display":" relationship to administration of the study 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However, if a constellation of signs","text_display":" jaundice, asterixis, and elevated transaminases). However, if a constellation of signs","confidence":1,"confidence_rate":1},{"cnt":[[430,1729],[1781,1729],[1781,1772],[430,1772]],"region":{"top_left_x":429,"top_left_y":1729,"width":1353,"height":44},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"efb1f4b716ae4689aa0d4594c8298e8d","type":"text","conversion_output":true,"text":"and/or symptoms cannot be medically characterized as a single diagnosis or syndrome","text_display":" and/or symptoms cannot be medically characterized as a single diagnosis or syndrome","confidence":1,"confidence_rate":1},{"cnt":[[430,1779],[1785,1779],[1785,1824],[430,1824]],"region":{"top_left_x":429,"top_left_y":1778,"width":1357,"height":47},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7160533c535f4866b8d11abd009a79b1","type":"text","conversion_output":true,"text":"at the time of reporting, each individual event should be recorded on the Adverse Event","text_display":" at the time of reporting, each individual event should be recorded on the Adverse Event","confidence":1,"confidence_rate":1},{"cnt":[[430,1826],[1790,1826],[1790,1869],[430,1869]],"region":{"top_left_x":429,"top_left_y":1826,"width":1361,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b229d3d721dd43de91d97b35dac5ff91","type":"text","conversion_output":true,"text":"eCRF. If a diagnosis is subsequently established, all previously reported AEs based on","text_display":" eCRF. 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This includes death","text_display":" and immediately reported to the Sponsor (see Section 5.2.2). This includes death","confidence":0.99853515625,"confidence_rate":0.9999827540583306},{"cnt":[[434,533],[926,533],[926,574],[434,574]],"region":{"top_left_x":433,"top_left_y":532,"width":493,"height":42},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfc538ac01e54f239db6849abd308669","type":"text","conversion_output":true,"text":"attributed to progression of AIS.","text_display":" attributed to progression of AIS.","confidence":1,"confidence_rate":1},{"cnt":[[434,621],[1807,621],[1807,655],[434,655]],"region":{"top_left_x":433,"top_left_y":620,"width":1374,"height":36},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d910f12cf3224705b74cac4868d19977","type":"text","conversion_output":true,"text":"Death should be considered an outcome and not a distinct event. 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The event or condition","confidence":1,"confidence_rate":1},{"cnt":[[432,668],[1800,666],[1800,709],[432,711]],"region":{"top_left_x":431,"top_left_y":666,"width":1370,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c05a118b28074e13969bf0d4750ffddf","type":"text","conversion_output":true,"text":"that caused or contributed to the fatal outcome should be recorded as the single medical","text_display":" that caused or contributed to the fatal outcome should be recorded as the single medical","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[434,713],[1674,713],[1674,758],[434,758]],"region":{"top_left_x":433,"top_left_y":713,"width":1241,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c57b2df6084c4a8da4e3a54023451647","type":"text","conversion_output":true,"text":"concept on the Adverse Event eCRF. 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The term \"sudden death\" should only be used for the occurrence of an abrupt","confidence":1,"confidence_rate":1},{"cnt":[[434,812],[1712,812],[1712,853],[434,853]],"region":{"top_left_x":433,"top_left_y":812,"width":1280,"height":41},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95cb478c862b426a870dfbccf166226d","type":"text","conversion_output":true,"text":"and unexpected death due to presumed cardiac causes in a patient with or without","text_display":" and unexpected death due to presumed cardiac causes in a patient with or without","confidence":1,"confidence_rate":1},{"cnt":[[434,855],[1807,855],[1807,900],[434,900]],"region":{"top_left_x":433,"top_left_y":855,"width":1374,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d15bcbb45044f369cafc1987d7dd6ce","type":"text","conversion_output":true,"text":"preexisting heart disease, within 1 hour of the onset of acute symptoms or, in the case of","text_display":" preexisting heart disease, within 1 hour of the onset of acute symptoms or, in the case of","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[434,907],[1764,907],[1764,947],[434,947]],"region":{"top_left_x":433,"top_left_y":906,"width":1331,"height":42},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1e657f460744b1d960e8abb1d50777f","type":"text","conversion_output":true,"text":"an unwitnessed death, within 24 hours after the patient was last seen alive and stable.","text_display":" an unwitnessed death, within 24 hours after the patient was last seen alive and stable.","confidence":1,"confidence_rate":1},{"cnt":[[434,952],[1725,952],[1725,995],[434,995]],"region":{"top_left_x":433,"top_left_y":951,"width":1293,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d334fd0b9174a38bb585b3ce578cf8d","type":"text","conversion_output":true,"text":"If the cause of death is unknown and cannot be ascertained at the time of reporting,","text_display":" If the cause of death is unknown and cannot be ascertained at the time of reporting,","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[432,1001],[1751,1001],[1751,1042],[432,1042]],"region":{"top_left_x":431,"top_left_y":1001,"width":1320,"height":41},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6094d7a39a247b9be69d058b0d984eb","type":"text","conversion_output":true,"text":"\"unexplained death\" should be recorded on the Adverse Event eCRF. If the cause of","text_display":" \"unexplained death\" should be recorded on the Adverse Event eCRF. If the cause of","confidence":1,"confidence_rate":1},{"cnt":[[432,1048],[1704,1048],[1704,1089],[432,1089]],"region":{"top_left_x":431,"top_left_y":1048,"width":1273,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6b500ed3f234f0c9087430c3f8800b9","type":"text","conversion_output":true,"text":"death later becomes available (e.g., after autopsy), \"unexplained death\" should be","text_display":" death later becomes available (e.g., after autopsy), \"unexplained death\" should be","confidence":1,"confidence_rate":1},{"cnt":[[434,1096],[1111,1096],[1111,1137],[434,1137]],"region":{"top_left_x":433,"top_left_y":1095,"width":678,"height":42},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"705919fab9624e3b9ee2f2a4d0cd7192","type":"text","conversion_output":true,"text":"replaced by the established cause of death.","text_display":" replaced by the established cause of death.","confidence":1,"confidence_rate":1},{"cnt":[[434,1182],[1708,1182],[1708,1222],[434,1222]],"region":{"top_left_x":433,"top_left_y":1181,"width":1276,"height":42},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c01e370676114959a51713f40c894690","type":"text","conversion_output":true,"text":"If the death is attributed to progression of AIS, \"acute ischemic stroke progression\"","text_display":"\n\nIf the death is attributed to progression of AIS, \"acute ischemic stroke progression\"","confidence":1,"confidence_rate":1},{"cnt":[[434,1229],[1188,1229],[1188,1265],[434,1265]],"region":{"top_left_x":433,"top_left_y":1228,"width":756,"height":38},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"764d20f5a37249b58d6ff1c6b81a92a8","type":"text","conversion_output":true,"text":"should be recorded on the Adverse Event eCRF.","text_display":" should be recorded on the Adverse Event 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Conditions}","confidence":0.99951171875,"confidence_rate":0.9999886419133848},{"cnt":[[432,1362],[1792,1362],[1792,1403],[432,1403]],"region":{"top_left_x":431,"top_left_y":1362,"width":1361,"height":41},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c01f54cc8b7349df9865999babcf2dd5","type":"text","conversion_output":true,"text":"A preexisting medical condition is one that is present at the screening visit for this study.","text_display":"\n\nA preexisting medical condition is one that is present at the screening visit for this study.","confidence":1,"confidence_rate":1},{"cnt":[[432,1409],[1691,1409],[1691,1450],[432,1450]],"region":{"top_left_x":431,"top_left_y":1409,"width":1260,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee7c727c6cc544439d79839814449a6c","type":"text","conversion_output":true,"text":"Such conditions should be recorded on the General Medical History and Baseline","text_display":" Such conditions should be recorded on the General Medical History and Baseline","confidence":1,"confidence_rate":1},{"cnt":[[434,1457],[711,1457],[711,1493],[434,1493]],"region":{"top_left_x":433,"top_left_y":1456,"width":279,"height":38},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"026af808882a4bd082c0ad6f194b0286","type":"text","conversion_output":true,"text":"Conditions eCRF.","text_display":" Conditions eCRF.","confidence":1,"confidence_rate":1},{"cnt":[[432,1543],[1708,1543],[1708,1586],[432,1586]],"region":{"top_left_x":431,"top_left_y":1542,"width":1278,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14d34ac587984b0db4ae317f98bb39db","type":"text","conversion_output":true,"text":"A preexisting medical condition should be recorded as an AE only if the frequency,","text_display":"\n\nA preexisting medical condition should be recorded as an AE only if the 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When recording such","text_display":" severity, or character of the condition worsens during the study. When recording such","confidence":1,"confidence_rate":1},{"cnt":[[434,1637],[1687,1637],[1687,1680],[434,1680]],"region":{"top_left_x":433,"top_left_y":1637,"width":1254,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f83725624c7c4a838544966ab1496658","type":"text","conversion_output":true,"text":"events on the Adverse Event eCRF, it is important to convey the concept that the","text_display":" events on the Adverse Event eCRF, it is important to convey the concept that the","confidence":1,"confidence_rate":1},{"cnt":[[434,1687],[1682,1687],[1682,1729],[434,1729]],"region":{"top_left_x":433,"top_left_y":1686,"width":1250,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c8d12eac1834362a5a5158ded038e5c","type":"text","conversion_output":true,"text":"preexisting condition has changed by including applicable descriptors (e.g., more","text_display":" preexisting condition has changed by including applicable descriptors (e.g., more","confidence":1,"confidence_rate":1},{"cnt":[[434,1732],[780,1732],[780,1777],[434,1777]],"region":{"top_left_x":433,"top_left_y":1731,"width":347,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ddf6640d1914dd388cb5c1237a01cda","type":"text","conversion_output":true,"text":"frequent headaches\").","text_display":" frequent headaches\").","confidence":1,"confidence_rate":1},{"cnt":[[430,1809],[1674,1809],[1674,1858],[430,1858]],"region":{"top_left_x":429,"top_left_y":1808,"width":1245,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe86feb38f50411b8721f9eb14497262","type":"section_header","conversion_output":false,"children_ids":["f5b943c813f0458bbb6127795b37ba2d"],"text":"","text_display":""},{"cnt":[[434,1813],[1669,1813],[1669,1854],[434,1854]],"region":{"top_left_x":433,"top_left_y":1813,"width":1237,"height":42},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5b943c813f0458bbb6127795b37ba2d","type":"text","conversion_output":true,"parent_id":"fe86feb38f50411b8721f9eb14497262","text":"5.3.3.8 Lack of Efficacy or Worsening of Acute Ischemic Stroke","text_display":"\n\n\\subsection*{5.3.3.8 Lack of Efficacy or Worsening of Acute Ischemic Stroke}","confidence":0.9975605006329715,"confidence_rate":0.9999635457421776},{"cnt":[[432,1865],[1807,1865],[1807,1910],[432,1910]],"region":{"top_left_x":431,"top_left_y":1864,"width":1376,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5425c131ed9a4c99ba6094c87e7c9034","type":"text","conversion_output":true,"text":"Medical occurrences or symptoms of deterioration that are considered part of the disease","text_display":"\n\nMedical occurrences or symptoms of deterioration that are considered part of the disease","confidence":1,"confidence_rate":1},{"cnt":[[434,1912],[1760,1912],[1760,1955],[434,1955]],"region":{"top_left_x":433,"top_left_y":1912,"width":1327,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9b31ef643ce42ae90076369350bf01a","type":"text","conversion_output":true,"text":"course or disease process should be recorded as an AE if judged by the investigator to","text_display":" course or disease process should be recorded as an AE if judged by the investigator to","confidence":1,"confidence_rate":1},{"cnt":[[432,1959],[1807,1959],[1807,2004],[432,2004]],"region":{"top_left_x":431,"top_left_y":1959,"width":1376,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"874853eebd864cc4be43616001328b3d","type":"text","conversion_output":true,"text":"have unexpectedly worsened in severity or frequency or unexpectedly changed in nature","text_display":" have unexpectedly worsened in severity or frequency or unexpectedly changed in nature","confidence":1,"confidence_rate":1},{"cnt":[[432,2007],[1689,2007],[1689,2050],[432,2050]],"region":{"top_left_x":431,"top_left_y":2006,"width":1258,"height":44},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a51c99ab16674730ad7efb34e4f79bdc","type":"text","conversion_output":true,"text":"at any time during the study. If there is uncertainty, it should be reported as an","text_display":" at any time during the study. If there is uncertainty, it should be reported as an","confidence":1,"confidence_rate":1},{"cnt":[[432,2054],[1755,2054],[1755,2099],[432,2099]],"region":{"top_left_x":431,"top_left_y":2053,"width":1325,"height":47},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6501e51457b647c0b5f1a0fb21de1afb","type":"text","conversion_output":true,"text":"AE. When recording unexpected worsening of AIS on the Adverse Event eCRF, it is","text_display":" AE. 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Was used for","confidence":0.711815357208252,"confidence_rate":0.9956513197946338},{"cnt":[[430,988],[870,988],[870,1033],[430,1033]],"region":{"top_left_x":429,"top_left_y":988,"width":442,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"911cb14fcce346938a56f9831aa72d61","type":"text","conversion_output":true,"text":"this sample size calculation.","text_display":" this sample size calculation.","confidence":1,"confidence_rate":1},{"cnt":[[430,1076],[1725,1076],[1725,1119],[430,1119]],"region":{"top_left_x":429,"top_left_y":1076,"width":1297,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8953ed7acd24ea7ad8ca5f1a92b46a9","type":"text","conversion_output":true,"text":"The ITT principle will be applied to the primary analysis and, therefore, to safeguard","text_display":"\n\nThe ITT principle will be applied to the primary analysis and, therefore, to safeguard","confidence":1,"confidence_rate":1},{"cnt":[[430,1126],[1577,1126],[1577,1167],[430,1167]],"region":{"top_left_x":429,"top_left_y":1125,"width":1148,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"606646b40e234d0eb86d25a0c0d1a71b","type":"text","conversion_output":true,"text":"against dilution of the treatment effect associated with an approximate \\(5 \\%\\)","text_display":" against dilution of the treatment effect associated with an approximate \\(5 \\%\\)","confidence":0.8452901840209961,"confidence_rate":0.997847508432811},{"cnt":[[430,1171],[1781,1171],[1781,1214],[430,1214]],"region":{"top_left_x":429,"top_left_y":1170,"width":1353,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ca55182256e413f892ffb51c22d24fc","type":"text","conversion_output":true,"text":"non-adherence rate (due to lost to follow-up, consent withdrawal, treatment crossovers,","text_display":" non-adherence rate (due to lost to follow-up, consent withdrawal, treatment crossovers,","confidence":1,"confidence_rate":1},{"cnt":[[430,1212],[1783,1212],[1783,1261],[430,1261]],"region":{"top_left_x":429,"top_left_y":1211,"width":1355,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff7cc4fd81474aaabca3d09ec0bd35d2","type":"text","conversion_output":true,"text":"and stroke mimics), the above sample size needs to be inflated by a factor of \\(1 / 0.95^{2}\\) or","text_display":" and stroke mimics), the above sample size needs to be inflated by a factor of \\(1 / 0.95^{2}\\) or","confidence":0.9951238604262471,"confidence_rate":0.9999525441675157},{"cnt":[[432,1268],[1760,1268],[1760,1311],[432,1311]],"region":{"top_left_x":431,"top_left_y":1267,"width":1329,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad0abcca132a46469520fd41b4fd5f5d","type":"text","conversion_output":true,"text":"1.108 (Friedman et al. 1998). Therefore, a total sample size of 948 is required for this","text_display":" 1.108 (Friedman et al. 1998). Therefore, a total sample size of 948 is required for this","confidence":1,"confidence_rate":1},{"cnt":[[430,1315],[531,1315],[531,1360],[430,1360]],"region":{"top_left_x":429,"top_left_y":1314,"width":102,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5c93a24b8e94a98a05d0f8f8a14f2f8","type":"text","conversion_output":true,"text":"study.","text_display":" study.","confidence":1,"confidence_rate":1},{"cnt":[[425,1388],[1042,1388],[1042,1437],[425,1437]],"region":{"top_left_x":425,"top_left_y":1387,"width":617,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20c552c0823f41339fb12e92de05e483","type":"section_header","conversion_output":false,"children_ids":["ef3410ae641b42da8b5fcef7e045c0e8"],"text":"","text_display":""},{"cnt":[[430,1392],[1038,1392],[1038,1433],[430,1433]],"region":{"top_left_x":429,"top_left_y":1392,"width":609,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef3410ae641b42da8b5fcef7e045c0e8","type":"text","conversion_output":true,"parent_id":"20c552c0823f41339fb12e92de05e483","text":"6.2 PRIMARY ANALYSIS","text_display":"\n\n\\subsection*{6.2 PRIMARY ANALYSIS}","confidence":0.9912109375,"confidence_rate":0.9996469457733739},{"cnt":[[430,1457],[1687,1457],[1687,1502],[430,1502]],"region":{"top_left_x":429,"top_left_y":1456,"width":1258,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21d66f9f93644fe3aeaaa1e5a225911c","type":"text","conversion_output":true,"text":"The primary efficacy analysis will test the hypothesis of superiority of IV alteplase","text_display":"\n\nThe primary efficacy analysis will test the hypothesis of superiority of IV alteplase","confidence":1,"confidence_rate":1},{"cnt":[[430,1504],[1704,1504],[1704,1549],[430,1549]],"region":{"top_left_x":429,"top_left_y":1503,"width":1275,"height":47},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d6fd1257541440b9928d0f15bb4b67f","type":"text","conversion_output":true,"text":"therapy over standard medical care in AIS patients with mild deficits. The primary","text_display":" therapy over standard medical care in AIS patients with mild deficits. The primary","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[430,1553],[1708,1553],[1708,1596],[430,1596]],"region":{"top_left_x":429,"top_left_y":1553,"width":1280,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52984c5a63fc4e6582992006abb8cddd","type":"text","conversion_output":true,"text":"efficacy outcome is the proportion of patients with a favorable outcome, defined by","text_display":" efficacy outcome is the proportion of patients with a favorable outcome, defined by","confidence":1,"confidence_rate":1},{"cnt":[[430,1603],[1781,1603],[1781,1644],[430,1644]],"region":{"top_left_x":429,"top_left_y":1602,"width":1353,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96e0ba1fee3e46ac8a1f2a004f9c3a35","type":"text","conversion_output":true,"text":"mRS score of 0 or 1 at 90 days post-randomization. The difference in the proportion of","text_display":" mRS score of 0 or 1 at 90 days post-randomization. The difference in the proportion of","confidence":0.9941475370433182,"confidence_rate":0.9999424560112985},{"cnt":[[430,1646],[1764,1646],[1764,1691],[430,1691]],"region":{"top_left_x":429,"top_left_y":1645,"width":1335,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0adceadc8684e2fa2c9c43533a55ae7","type":"text","conversion_output":true,"text":"mRS 0-1 responders (favorable outcome) at 90 days post-randomization between the","text_display":" mRS 0-1 responders (favorable outcome) at 90 days post-randomization between the","confidence":0.2929687324797073,"confidence_rate":0.9864516235112508},{"cnt":[[430,1697],[1592,1697],[1592,1738],[430,1738]],"region":{"top_left_x":429,"top_left_y":1697,"width":1163,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7ab1bc0ab6246deac4c99929378e6aa","type":"text","conversion_output":true,"text":"IV alteplase arm and the standard medical care arm will be compared via a","text_display":" IV alteplase arm and the standard medical care arm will be compared via a","confidence":1,"confidence_rate":1},{"cnt":[[430,1745],[1777,1745],[1777,1790],[430,1790]],"region":{"top_left_x":429,"top_left_y":1744,"width":1348,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9398136dc8042e08944027d1c35aadf","type":"text","conversion_output":true,"text":"Cochran-Mantel-Haenszel test, stratified by pre-treatment NIHSS score (0-2 vs. 3-5),","text_display":" Cochran-Mantel-Haenszel test, stratified by pre-treatment NIHSS score (0-2 vs. 3-5),","confidence":0.635341580776867,"confidence_rate":0.9949164203808675},{"cnt":[[430,1792],[1777,1792],[1777,1837],[430,1837]],"region":{"top_left_x":429,"top_left_y":1791,"width":1348,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1025a8aa98d482299e1614d222e75a1","type":"text","conversion_output":true,"text":"age ( \\(<65\\) vs. \\(\\geq 65\\) ), and last known well time to treatment ( \\(0-2\\) hours vs. \\(>2-3\\) hours).","text_display":" age ( \\(<65\\) vs. \\(\\geq 65\\) ), and last known well time to treatment ( \\(0-2\\) hours vs. \\(>2-3\\) hours).","confidence":0.7663231728283529,"confidence_rate":0.9974441246948936},{"cnt":[[430,1839],[1785,1839],[1785,1882],[430,1882]],"region":{"top_left_x":429,"top_left_y":1839,"width":1357,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f5338b02965492da346687ec9d41c65","type":"text","conversion_output":true,"text":"The primary efficacy analysis will include all randomized patients, with patients grouped","text_display":" The primary efficacy analysis will include all randomized patients, with patients grouped","confidence":1,"confidence_rate":1},{"cnt":[[430,1886],[1803,1886],[1803,1931],[430,1931]],"region":{"top_left_x":429,"top_left_y":1886,"width":1374,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5dd7719c62f4476c98c3db47aa4d158c","type":"text","conversion_output":true,"text":"according to the treatment assigned at randomization adhering to the ITT principle. As a","text_display":" according to the treatment assigned at randomization adhering to the ITT principle. As a","confidence":1,"confidence_rate":1},{"cnt":[[430,1934],[1729,1934],[1729,1979],[430,1979]],"region":{"top_left_x":429,"top_left_y":1933,"width":1301,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d48714d158e4015b568aada0a74d077","type":"text","conversion_output":true,"text":"sensitivity analysis, results from the univariate Pearson's chi-square test will also be","text_display":" sensitivity analysis, results from the univariate Pearson's chi-square test will also be","confidence":1,"confidence_rate":1},{"cnt":[[430,1981],[604,1981],[604,2026],[430,2026]],"region":{"top_left_x":429,"top_left_y":1980,"width":175,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6153104011a41eaa99a5bb301030007","type":"text","conversion_output":true,"text":"presented.","text_display":" presented.","confidence":1,"confidence_rate":1},{"cnt":[[430,2067],[1781,2067],[1781,2112],[430,2112]],"region":{"top_left_x":429,"top_left_y":2066,"width":1353,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be35f8fc4e1440efbbef3bba68b49b63","type":"text","conversion_output":true,"text":"As a supportive, secondary analysis, an ordinal (or \"shift\") analysis of the distribution of","text_display":"\n\nAs a supportive, secondary analysis, an ordinal (or \"shift\") analysis of the distribution of","confidence":1,"confidence_rate":1},{"cnt":[[430,2118],[1768,2118],[1768,2159],[430,2159]],"region":{"top_left_x":429,"top_left_y":2118,"width":1340,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a983e34808f244569bcaecfef82c7a39","type":"text","conversion_output":true,"text":"the mRS will be analyzed via proportional odds model if the proportionality assumption","text_display":" the mRS will be analyzed via proportional odds model if the proportionality assumption","confidence":0.994140625,"confidence_rate":0.9999394182424789},{"cnt":[[430,2161],[1755,2161],[1755,2206],[430,2206]],"region":{"top_left_x":429,"top_left_y":2161,"width":1327,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba453cae00444200908419b879acbde0","type":"text","conversion_output":true,"text":"holds, and by the Mann-Whitney superiority measure if the proportionality assumption","text_display":" holds, and by the Mann-Whitney superiority measure if the proportionality assumption","confidence":1,"confidence_rate":1},{"cnt":[[430,2211],[1777,2211],[1777,2254],[430,2254]],"region":{"top_left_x":429,"top_left_y":2210,"width":1348,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab65fdbb0b9648ec8297924e480315ce","type":"text","conversion_output":true,"text":"does not hold. The proportionality assumption will be assessed using the score test as","text_display":" does not hold. The proportionality assumption will be assessed using the score test as","confidence":1,"confidence_rate":1},{"cnt":[[430,2256],[1772,2256],[1772,2301],[430,2301]],"region":{"top_left_x":429,"top_left_y":2255,"width":1344,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fa79ecfaee8414584c8e14cb6533ff3","type":"text","conversion_output":true,"text":"well as clinical judgment on the similarities of the different odds ratios. As a secondary","text_display":" well as clinical judgment on the similarities of the different odds ratios. 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The significance of each test is determined at the two-sided alpha level of","text_display":" evidence. The significance of each test is determined at the two-sided alpha level of","confidence":0.96826171875,"confidence_rate":0.9996416991202127},{"cnt":[[430,488],[1768,488],[1768,531],[430,531]],"region":{"top_left_x":429,"top_left_y":487,"width":1340,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abf884dfcce94798b1dc4a11dd95ac1e","type":"text","conversion_output":true,"text":"0.05 . The specific statistical model for analyzing each of these outcome measures will","text_display":" 0.05 . The specific statistical model for analyzing each of these outcome measures will","confidence":0.97509765625,"confidence_rate":0.9997229213302704},{"cnt":[[430,535],[1192,535],[1192,578],[430,578]],"region":{"top_left_x":429,"top_left_y":534,"width":764,"height":44},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46481b270c6743ef9aff05a8ea0e1fa4","type":"text","conversion_output":true,"text":"be detailed in the Statistical Analysis Plan (SAP).","text_display":" be detailed in the Statistical Analysis Plan (SAP).","confidence":1,"confidence_rate":1},{"cnt":[[425,610],[1016,610],[1016,660],[425,660]],"region":{"top_left_x":425,"top_left_y":610,"width":592,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41a5c3a38ddf41d89aa24825da64f06e","type":"section_header","conversion_output":false,"children_ids":["deede873733e441e957499300f906612"],"text":"","text_display":""},{"cnt":[[432,614],[1016,614],[1016,655],[432,655]],"region":{"top_left_x":431,"top_left_y":614,"width":586,"height":42},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"deede873733e441e957499300f906612","type":"text","conversion_output":true,"parent_id":"41a5c3a38ddf41d89aa24825da64f06e","text":"6.3 SAFETY ANALYSIS","text_display":"\n\n\\subsection*{6.3 SAFETY ANALYSIS}","confidence":0.9492673873901367,"confidence_rate":0.9978329862443398},{"cnt":[[432,679],[1717,679],[1717,724],[432,724]],"region":{"top_left_x":431,"top_left_y":678,"width":1286,"height":47},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d38fa106bbb14affba69264e1c4005ff","type":"text","conversion_output":true,"text":"Incidence and severity of AEs will be described for all treated patients by treatment","text_display":"\n\nIncidence and severity of AEs will be described for all treated patients by treatment","confidence":1,"confidence_rate":1},{"cnt":[[432,726],[1734,726],[1734,771],[432,771]],"region":{"top_left_x":431,"top_left_y":726,"width":1303,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"538f3065dfbc49bfae914e281bb2b1e0","type":"text","conversion_output":true,"text":"group as received and by the Medical Dictionary for Regulatory Activities (MedDRA)","text_display":" group as received and by the Medical Dictionary for Regulatory Activities (MedDRA)","confidence":1,"confidence_rate":1},{"cnt":[[432,776],[642,776],[642,814],[432,814]],"region":{"top_left_x":431,"top_left_y":775,"width":212,"height":40},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75a8927ad5634d9c9b9a932b0f57028c","type":"text","conversion_output":true,"text":"classification.","text_display":" classification.","confidence":1,"confidence_rate":1},{"cnt":[[432,859],[1796,859],[1796,904],[432,904]],"region":{"top_left_x":431,"top_left_y":859,"width":1366,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c217c7a3f2bd4edd90777b63644c1c8c","type":"text","conversion_output":true,"text":"Safety outcomes include incidence of sICH within 36 hours (primary safety assessment),","text_display":"\n\nSafety outcomes include incidence of sICH within 36 hours (primary safety assessment),","confidence":0.982445478439331,"confidence_rate":0.9998116089237735},{"cnt":[[430,907],[1751,907],[1751,952],[430,952]],"region":{"top_left_x":429,"top_left_y":906,"width":1322,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3d48ba5ee1f4a9a84e41e7b43ee2f3d","type":"text","conversion_output":true,"text":"any ICH within 36 hours, overall mortality, and stroke-related and neurological deaths","text_display":" any ICH within 36 hours, overall mortality, and stroke-related and neurological deaths","confidence":1,"confidence_rate":1},{"cnt":[[430,958],[1772,958],[1772,999],[430,999]],"region":{"top_left_x":429,"top_left_y":958,"width":1344,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b5a0379ff724b86b6f2a8e11905c0d6","type":"text","conversion_output":true,"text":"within 90 days of study drug initiation. The cumulative incidences of each outcome will","text_display":" within 90 days of study drug initiation. The cumulative incidences of each outcome will","confidence":1,"confidence_rate":1},{"cnt":[[430,1005],[1803,1005],[1803,1046],[430,1046]],"region":{"top_left_x":429,"top_left_y":1005,"width":1374,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"321ba6094015491ab76fdff753146bb3","type":"text","conversion_output":true,"text":"be compared via Fisher's exact test. Mortality will be analyzed by Log-Rank test and the","text_display":" be compared via Fisher's exact test. 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No alpha","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[432,1100],[1689,1100],[1689,1145],[432,1145]],"region":{"top_left_x":431,"top_left_y":1100,"width":1258,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ceba24579b74bbb8c771765edcf845c","type":"text","conversion_output":true,"text":"adjustment for multiple testing on the safety endpoints is foreseen because those","text_display":" adjustment for multiple testing on the safety endpoints is foreseen because those","confidence":1,"confidence_rate":1},{"cnt":[[430,1147],[874,1147],[874,1190],[430,1190]],"region":{"top_left_x":429,"top_left_y":1147,"width":446,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be8fd7d5c8a74acf8b501cc5bacc5e5d","type":"text","conversion_output":true,"text":"analyses will be exploratory.","text_display":" analyses will be exploratory.","confidence":1,"confidence_rate":1},{"cnt":[[425,1220],[1171,1220],[1171,1268],[425,1268]],"region":{"top_left_x":425,"top_left_y":1220,"width":746,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1dfd7e82d384b5ab2850cd836621aab","type":"section_header","conversion_output":false,"children_ids":["8a6d25d3e1d64e99a0e74f9f15a1f0b7"],"text":"","text_display":""},{"cnt":[[432,1225],[1167,1225],[1167,1265],[432,1265]],"region":{"top_left_x":431,"top_left_y":1224,"width":736,"height":42},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a6d25d3e1d64e99a0e74f9f15a1f0b7","type":"text","conversion_output":true,"parent_id":"b1dfd7e82d384b5ab2850cd836621aab","text":"6.4 EXPLORATORY ANALYSES","text_display":"\n\n\\subsection*{6.4 EXPLORATORY ANALYSES}","confidence":0.980478048324585,"confidence_rate":0.9993204026915297},{"cnt":[[430,1291],[1785,1291],[1785,1334],[430,1334]],"region":{"top_left_x":429,"top_left_y":1291,"width":1357,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ed250096cbb4b0797e26fee65668f84","type":"text","conversion_output":true,"text":"As exploratory analyses, heterogeneity of treatment effect of alteplase will be evaluated","text_display":"\n\nAs exploratory analyses, heterogeneity of treatment effect of alteplase will be evaluated","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[430,1338],[1755,1338],[1755,1381],[430,1381]],"region":{"top_left_x":429,"top_left_y":1338,"width":1327,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5353eda37c044537ac73a4414c8e9dc1","type":"text","conversion_output":true,"text":"by various pre-specified baseline covariates. The primary pre-specified variables and","text_display":" by various pre-specified baseline covariates. The primary pre-specified variables and","confidence":1,"confidence_rate":1},{"cnt":[[430,1388],[1044,1388],[1044,1429],[430,1429]],"region":{"top_left_x":429,"top_left_y":1387,"width":616,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df0dd886309143c189e6dab06a3421be","type":"text","conversion_output":true,"text":"their analytic thresholds are defined by:","text_display":" their analytic thresholds are defined by:","confidence":1,"confidence_rate":1},{"cnt":[[432,1444],[793,1444],[793,1487],[432,1487]],"region":{"top_left_x":431,"top_left_y":1443,"width":362,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b7fe2c3a5b5489aa205280a8db22bfd","type":"text","conversion_output":true,"text":"- Age (<65 vs. \\(\\geq 65\\) )","text_display":"\n- Age (<65 vs. \\(\\geq 65\\) )","confidence":0.9839017355116084,"confidence_rate":0.9994205519020218},{"cnt":[[432,1497],[1162,1497],[1162,1540],[432,1540]],"region":{"top_left_x":431,"top_left_y":1497,"width":732,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f618d719727f4b50920b15f9a0c68dd1","type":"text","conversion_output":true,"text":"- Pre-treatment NIHSS score (0-2 vs. 3-5)","text_display":"\n- Pre-treatment NIHSS score (0-2 vs. 3-5)","confidence":0.9658203125,"confidence_rate":0.9992442536772432},{"cnt":[[430,1551],[1381,1551],[1381,1594],[430,1594]],"region":{"top_left_x":429,"top_left_y":1551,"width":953,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2da910ed7246442c9356c7ebccc806e9","type":"text","conversion_output":true,"text":"- Last known well time to treatment ( \\(0-2\\) vs. \\(>2-3\\) hours)","text_display":"\n- Last known well time to treatment ( \\(0-2\\) vs. \\(>2-3\\) hours)","confidence":0.8864153688818988,"confidence_rate":0.9982284882678286},{"cnt":[[432,1603],[1094,1603],[1094,1648],[432,1648]],"region":{"top_left_x":431,"top_left_y":1602,"width":663,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5616fed36d964e4bb25a759d3a387ca7","type":"text","conversion_output":true,"text":"- Stroke subgroup (RISS vs. non-RISS)","text_display":"\n- Stroke subgroup (RISS vs. non-RISS)","confidence":1,"confidence_rate":1},{"cnt":[[430,1684],[1751,1684],[1751,1727],[430,1727]],"region":{"top_left_x":429,"top_left_y":1684,"width":1322,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b96c5db56b874fa2a5c245b0996f6616","type":"text","conversion_output":true,"text":"Additional heterogeneity analyses will be considered and detailed in the SAP. Forest","text_display":"\n\nAdditional heterogeneity analyses will be considered and detailed in the SAP. Forest","confidence":1,"confidence_rate":1},{"cnt":[[432,1732],[1687,1732],[1687,1777],[432,1777]],"region":{"top_left_x":431,"top_left_y":1731,"width":1256,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0f813d74d6e44fea6d288bcb4c0268f","type":"text","conversion_output":true,"text":"plots will be constructed to illustrate subgroup analyses. In addition, the two-way","text_display":" plots will be constructed to illustrate subgroup analyses. 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Additional exploratory analyses will be conducted to","text_display":" multivariable logistic regression. 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ASSESSMENTS & Screening and Baseline (Visit 1) & Study Drug Administration & 22-36 Hours from Start of Study Drug Administration (Visit 2) & Day 5 (or Discharge if Sooner) (Visit 3) & 30 Days ( ± 7 Days) Phone Call (Visit 4) & \\(90( \\pm 14)\\) Days/Study Completion (Visit 5) & Early Discontinuation (Phone call, if possible) \\\\\n\\hline Informed consent & X & & & & & & \\\\\n\\hline Review of eligibility & X & & & & & & \\\\\n\\hline Medical history and baseline conditions \\({ }^{\\text {a }}\\) & X & & & & & & \\\\\n\\hline Demographics & X & & & & & & \\\\\n\\hline Neurological examination \\({ }^{\\text {b }}\\) & X & & & & & & \\\\\n\\hline Vital signs \\({ }^{\\text {c }}\\) & X & & & & & & \\\\\n\\hline Complete blood count \\({ }^{\\text {d }}\\) & X & & & & & & \\\\\n\\hline Coagulation status \\({ }^{\\text {e }}\\) & X & & & & & & \\\\\n\\hline Pregnancy test \\({ }^{\\text {f }}\\) & X & & & & & & \\\\\n\\hline Serum blood glucose \\({ }^{\\text {g }}\\) & X & & & & & & \\\\\n\\hline Imaging modality sensitive to presence of intracranial hemorrhage (either CT or MRI with DW MRI, either SW or GRE, and FLAIR images). 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Serum or urine pregnancy test can be collected.","confidence":0.99853515625,"confidence_rate":0.9999891414094549},{"cnt":[[331,1014],[1377,1014],[1377,1055],[331,1055]],"region":{"top_left_x":330,"top_left_y":1014,"width":1048,"height":41},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c6a3b252d5a40609b0ba4a0dcdb19c4","type":"text","conversion_output":true,"text":"\\({ }^{ g }\\) Serum glucose (values of \\(<50 mg / dL\\) are contraindicated for alteplase).","text_display":"\n\\({ }^{ g }\\) Serum glucose (values of \\(<50 mg / dL\\) are contraindicated for alteplase).","confidence":0.9931640625,"confidence_rate":0.9999270302203931},{"cnt":[[331,1053],[1394,1053],[1394,1100],[331,1100]],"region":{"top_left_x":330,"top_left_y":1052,"width":1065,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb7738f941b4486c8f639f7492962894","type":"text","conversion_output":true,"text":"\\({ }^{h}\\) MRI or CT scan should be performed if any clinical findings suggest ICH.","text_display":"\n\\({ }^{h}\\) MRI or CT scan should be performed if any clinical findings suggest ICH.","confidence":0.7197265625,"confidence_rate":0.9961382532857633},{"cnt":[[331,1100],[1768,1100],[1768,1145],[331,1145]],"region":{"top_left_x":330,"top_left_y":1100,"width":1439,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61fd276693034152992f65df6d104111","type":"text","conversion_output":true,"text":"\\({ }^{1}\\) NIHSS score should be assessed and recorded at the time of any clinical findings that suggest ICH.","text_display":"\n\\({ }^{1}\\) NIHSS score should be assessed and recorded at the time of any clinical findings that suggest ICH.","confidence":0.48732221126556396,"confidence_rate":0.9935449800392159},{"cnt":[[331,1143],[1571,1143],[1571,1188],[331,1188]],"region":{"top_left_x":330,"top_left_y":1142,"width":1241,"height":47},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28e55aa75f554a92ae533b6bcbea2cbe","type":"text","conversion_output":true,"text":"\\({ }^{ j }\\) The mRS may be performed by telephone, if necessary, for visits on Days 30 and 90.","text_display":"\n\\({ }^{ j }\\) The mRS may be performed by telephone, if necessary, for visits on Days 30 and 90.","confidence":0.9296170411096227,"confidence_rate":0.9992704406439941},{"cnt":[[331,1186],[2396,1186],[2396,1231],[331,1231]],"region":{"top_left_x":330,"top_left_y":1185,"width":2066,"height":47},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae729b0d18ab47ffbb393be9086d0356","type":"text","conversion_output":true,"text":"\\({ }^{ k }\\) The BI, CES-D, EQ-5D, and SIS-16 can be administered by phone interview if an in-person patient visit cannot be scheduled in the allotted time.","text_display":"\n\\({ }^{ k }\\) The BI, CES-D, EQ-5D, and SIS-16 can be administered by phone interview if an in-person patient visit cannot be scheduled in the allotted time.","confidence":0.99560546875,"confidence_rate":0.999972300914539},{"cnt":[[331,1229],[2408,1229],[2408,1278],[331,1278]],"region":{"top_left_x":330,"top_left_y":1228,"width":2079,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d615a192de254546983572e2414b03f3","type":"text","conversion_output":true,"text":"\\({ }^{1}\\) Assessments include: Controlled Oral Word Association test; HVLT-R trials 1, 2, and 3; digit symbol coding from the WAIS III; Forward and","text_display":"\n\\({ }^{1}\\) Assessments include: Controlled Oral Word Association test; HVLT-R trials 1, 2, and 3; digit symbol coding from the WAIS III; Forward and","confidence":0.994631290435791,"confidence_rate":0.9999641128247945},{"cnt":[[365,1276],[2402,1276],[2402,1317],[365,1317]],"region":{"top_left_x":365,"top_left_y":1276,"width":2037,"height":41},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"464ba71abbf94fcfbb273c4c79ef3487","type":"text","conversion_output":true,"text":"Backward Digit Span test; Benton Judgment of Line Orientation, form V; HVLT-R trial 4 and recognition; semantic fluency (Animal Naming","text_display":" Backward Digit Span test; Benton Judgment of Line Orientation, form V; HVLT-R trial 4 and recognition; semantic fluency (Animal Naming","confidence":1,"confidence_rate":1},{"cnt":[[365,1315],[896,1315],[896,1356],[365,1356]],"region":{"top_left_x":365,"top_left_y":1314,"width":531,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d9136ecd92c4f9b90abc4d955fa32ba","type":"text","conversion_output":true,"text":"test); and BNT (15-item short form).","text_display":" test); and BNT (15-item short form).","confidence":0.99853515625,"confidence_rate":0.9999642465493529},{"cnt":[[331,1354],[2391,1354],[2391,1399],[331,1399]],"region":{"top_left_x":330,"top_left_y":1353,"width":2062,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8319a747ffc4588a8843d831687c8c0","type":"text","conversion_output":true,"text":"\\({ }^{ m }\\) Assessment of walking speed requires an in-person patient visit and is best combined with administration of the BI, CES-D, EQ-5D, and SIS-16.","text_display":"\n\\({ }^{ m }\\) Assessment of walking speed requires an in-person patient visit and is best combined with administration of the BI, CES-D, EQ-5D, and SIS-16.","confidence":0.9912149906158447,"confidence_rate":0.9999437988718449},{"cnt":[[331,1396],[2292,1396],[2292,1442],[331,1442]],"region":{"top_left_x":330,"top_left_y":1396,"width":1963,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20a8ec09ffa640deb885b46f792ae969","type":"text","conversion_output":true,"text":"\\({ }^{ n }\\) Concomitant medications include any prescription medications or over-the-counter preparations used by the patient within 7 days prior to","text_display":"\n\\({ }^{ n }\\) Concomitant medications include any prescription medications or over-the-counter preparations used by the patient within 7 days prior to","confidence":0.7068285942077637,"confidence_rate":0.9977640062538692},{"cnt":[[365,1439],[522,1439],[522,1480],[365,1480]],"region":{"top_left_x":365,"top_left_y":1439,"width":158,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eda754a7408446968e71053f26c98640","type":"text","conversion_output":true,"text":"screening.","text_display":" screening.","confidence":1,"confidence_rate":1},{"cnt":[[331,1480],[2413,1480],[2413,1525],[331,1525]],"region":{"top_left_x":330,"top_left_y":1480,"width":2083,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8073b7150aab456ebab8af3a2c7f8292","type":"text","conversion_output":true,"text":"\\({ }^{\\text {- }}\\) Adverse event assessments will be performed during study drug administration; at \\(22-36\\) hours after study drug administration; on Days 5, 30,","text_display":"\n\\({ }^{\\text {- }}\\) Adverse event assessments will be performed during study drug administration; at \\(22-36\\) hours after study drug administration; on Days 5, 30,","confidence":0.4896412478811786,"confidence_rate":0.9955745275812159},{"cnt":[[365,1523],[2322,1523],[2322,1566],[365,1566]],"region":{"top_left_x":365,"top_left_y":1523,"width":1958,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae63e21397f74821842ded0e82767c88","type":"text","conversion_output":true,"text":"and 90 (may be done via telephone interview if necessary), and at early discontinuation. Refer to Section 5.3.1 (Adverse Event Reporting","text_display":" and 90 (may be done via telephone interview if necessary), and at early discontinuation. Refer to Section 5.3.1 (Adverse Event Reporting","confidence":1,"confidence_rate":1},{"cnt":[[365,1560],[750,1560],[750,1603],[365,1603]],"region":{"top_left_x":365,"top_left_y":1559,"width":385,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dca678791ccc40eeb301bec5b39a5e66","type":"text","conversion_output":true,"text":"Period) for further details.","text_display":" Period) for further details.","confidence":0.9990234375,"confidence_rate":0.9999703931762353},{"cnt":[[331,1818],[750,1818],[750,1858],[331,1858]],"region":{"top_left_x":330,"top_left_y":1817,"width":420,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f2567977dee49558b70fd152aba723a","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, 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vials-Administer using either a polyvinyl chloride bag or glass vial and infusion set.","confidence":0.9951229095458984,"confidence_rate":0.9999495989787247},{"cnt":[[432,2144],[1437,2144],[1437,2181],[432,2181]],"region":{"top_left_x":431,"top_left_y":2144,"width":1007,"height":37},"line":34,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"077460b06624421e8b0242a01e942d10","type":"text","conversion_output":true,"text":"No medication should be added to the infusion solutions that contain alteplase.","text_display":"\n\nNo medication should be added to the infusion solutions that contain alteplase.","confidence":1,"confidence_rate":1},{"cnt":[[430,2213],[1738,2213],[1738,2245],[430,2245]],"region":{"top_left_x":429,"top_left_y":2212,"width":1310,"height":34},"line":35,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4f88825098d743d99d05cba765978bb2","type":"text","conversion_output":true,"text":"For specifics regarding dosing and 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Reconstitute","text_display":"\n\nA single \\(50- mg\\) vial of Activase may be used to treat patients weighing up to 122 lbs or 55.5 kilograms. 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Swab the top of each","text_display":"\n\nRemove the protective cap from the top of the Actixase vial and the vial of SWFI. Swab the top of each","confidence":0.47487759590148926,"confidence_rate":0.9930643670213912},{"cnt":[[580,1328],[1291,1328],[1291,1360],[580,1360]],"region":{"top_left_x":580,"top_left_y":1327,"width":712,"height":33},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73ae95c1c31a462cad934310f6a4d1b2","type":"text","conversion_output":true,"text":"vial with an alcohol wipe to reduce the risk of contamination","text_display":" vial with an alcohol wipe to reduce the risk of contamination","confidence":1,"confidence_rate":1},{"cnt":[[537,1388],[638,1388],[638,1429],[537,1429]],"region":{"top_left_x":537,"top_left_y":1387,"width":102,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"984813670b9e461eababe33a25c760cc","type":"section_header","conversion_output":false,"children_ids":["5a39c856eccf4a448502c0364a4874a7"],"text":"","text_display":""},{"cnt":[[541,1392],[634,1392],[634,1429],[541,1429]],"region":{"top_left_x":541,"top_left_y":1392,"width":93,"height":37},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a39c856eccf4a448502c0364a4874a7","type":"text","conversion_output":true,"parent_id":"984813670b9e461eababe33a25c760cc","text":"Step 3:","text_display":"\n\n\\section*{Step 3:}","confidence":1,"confidence_rate":1},{"cnt":[[580,1431],[1794,1431],[1794,1467],[580,1467]],"region":{"top_left_x":580,"top_left_y":1430,"width":1214,"height":38},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d62a08ed350a4c21823a4caeae70b9ec","type":"text","conversion_output":true,"text":"Withdraw \\(50- mL\\) of SWFI, without preservatives. 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Please tell me how often you have felt this way during the past week.","text_display":"\n\nBelow is a list of the ways you might have felt or behaved. 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week.","confidence":1,"confidence_rate":1},{"cnt":[[440,578],[1824,578],[1824,1830],[440,1830]],"region":{"top_left_x":440,"top_left_y":577,"width":1385,"height":1254},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49a041eb21384e40b014404a1d1dd945","type":"table","conversion_output":true,"children_ids":["0de103d05d9f4bb2959ca12d3d97fe7a","78c58fcd5d024d4fbf8c26583b1e05f1","b813f65ac1054f75bc4485da49a28a53","3c3bb0371735488999d5f34de60670ce","f4f282ddf47c45c3baf950b13b7c1a25","a2a40c9f956d465099b430e338cd4ab3","3a998606044944bb9bc9750e566cbaf4","f38e1a6e553e4c4780e6495ce11f334e","04625e462235401f88e4694697275b17","55dbdef42dac4b2fa1785ba1949368a4","bc0d4f230dfb4866893a748487f43b28","60f9f909bd0641038093375f4a6048d5","d8a218e09e034e6d80ae11e8e9e76c5d","bc1792e897904a0980f936a2a0d39b0f","fee99b23869d4f6e866859e3db2fe9a3","850a604a37ad4fc8902d4a8064fcc5d4","235bbe8426cd4e4688ef3dd525ef6075","abaca794898e424491d99a49cabb5d60","ffbc3ff77f084e15955b4cd8ec230a04","ce9da31a83974aeda2f51ba06ffdffa9","628a8de329f4486fb1be0ee4033c2ad9","8a2f5757ccd24770967a67a11616ebd6","024ee603f7c1401cb187b10853a29ce9","e2c070f19a6a4962b10f8208cb96f5c5","c4d0f83a3a5a4148a709ccca9dfd0d73","36157253ad3949afa9fa78f70a9f0529","baff2566f26446b68e17f690b258409a","f861aad062364504adc85166ccc3305a","25ee870c9d60441f8ca19d2a7112beb8","3841d555cdcf4b24829e9eaac705be6b","d515b525f883462abe38b3ced1916c07","047d945fbd51475196d0f944f1e800f2","2586a1f159de4a21abaea4426b2ba85e","fb300c706713425b9abff88705e6681b","71e80eea5833430e9e530d4d0c694677","72f8f40367b9474cb9a7be5a5c78da82","7896fc7d075f44bb9e40e701665af47b","ffec6aa314464257925fa329464213d3","80200036aae8486aaf9bfbcf1e05a520","f0a41949be2645a997195f564513dcd0","85b0204ac7e64223bbf067a112a3ccf6","25b2b22507504ce283cfab3d251e82f7","d0a26458438a45fa857aae68ed376852","e9e7747db8fb44e4bc47fd0d9a3c5ac9","35453f229ee246ec9fe2f0a6c92927a6","7e6f62a5f79e418886294bdde7ece7a1","c17220c669a8452a9c3b1680730a6433","d62f738b9a4b4949a1746852fd58fee9","5339e93faff44d06b3f89dae73796941","1a5b6127d81744868cee75f0edca9d94","7304e6ccf0a7428f91c4f7dd18c41719","503b836bb1104d2dbde0350df03a3cb6","d899fe77aa4542fcacb6fbc1029d0edc","46171b433db344a8bc856405727c8cd1","4d499b3d56fe46978c107cb1932c08fb","12552ddd8ff94411b067a3c5358e3e2f","7c41aecaf592491db9dbcc489a70821d","7c450adcba70432495188f86b203b470","ce4d8b48a782489ca3d5d6ad4c4f1040","7b0041238cda49b8915822fcb57a1ae3","8ec31786e8034530a954d6323b37f02b","a9b4fa2a694c4049b59d03157fba8bb6","c9d1661dffbf4964b6a48a12ce4121d0","2ba7dbc242f94449b0434b8a222559b6","1de867b936024fb09ab92934b7b037f2","13b884bd962c413a82873d0a7138d4a5","97808f03eeb740ef86f6dc82f82d4262","89a3f83e0b604d2c99e0fa17a1d6055e","30c77be6687d488a9a673111d98530a3","c17c5d91fb4a41be8f791472b2872140","83f3ef11cf4346188f91731352e2388c","45bbe2d0eb114cf78f4917ecf146effd","5162e52d43f14f3c9689e6a1526bc457","8214cf1d762b439cbd7b870a2a66f41e","42dc6ac246404d469a4acfafea1c84c2","b7330f2f2c5c4a54807ed9c20c983356","caf4bf0746fb432eb1be3c47ac512c11","fc14d36f4b4945afb089db2dbbcd70ec","1bae26c651fd4e92b62ec80b32b91cdd","f5645edd5eea4585be08631d94b4f296","dd4f153a61b84b25903165a6abfe9e39","73aa69775fd743159a8f6e09279657ab","de6a9be07fae4cd9ac75c7006c666aaa","d5c41a6c38f947bc971a0760467d9945","5ab40a8106f64ac3ae35c2e3bc6fa336","d435dacbc22343409a53396aec16a0f5","0692c8b5ffda4aba9168fe24fa2a8f47","2d6ff5154fdb4126b07435b8e1be4045","6fad7ded63aa43788870e27877784491","feccbdf33f6743c1880da39f3c729a71","6d6fc3c89f724caa91f2d42be391b312","2f6eda3fcfc640f39ff3107748444ed9","aa29345eed164a0387f81e594fb2532d","7725d7cfb3a0477b98a9ba3b4dd751b5","6bdc5d22452147829f469110ad20f3ec","989b9437796c4f929de6079798460c37","5573f0688f01465d93631b7113d74261","692ada1aadaa42159d5fe39908ffd179","641d8d7128544888abc58af7fb10ab5a","4a33a5ba1b42492f8f48d83f3151be0d","e0a90e20395f4f889c55e8861f86e239","53564ef83952408db001649f1275e818","90a85d149a8140f29d6a482bcc4cc022","9feb8941a7684394acadfd4b5c10e90b","4979eb57785c41a88c7492b2a4f86cf7","7159d71bd2c147da8961ec1428d44a56","62482e017552401893dd88d8836125b0","bb8aa9cc07d54587baa4a5cab6ce1413","9abfe5089bbf4fc29be8c3e5259861dd","0aac184f20d743e08d7523a9f60e1185","07bbb19e415b40c28de0b16fdb4fa625","3c1cad7c1cbb49e09a4862af47fa32e7","b7ef3ea84a164a56917de1a28cd29f6c","80d03bb1c8ae49e988fce13d1bf0305a","32d9ed4343bf4525b3ff19d036621049","2490d9fefe514307b3934ead9402e796","fb2d8644ad764f9ea0cfd837ed6563e7","d32adc5b3a4847149a50ffcbfec09601","0574d037c4af4841b5c21e343b89a8df","e30ae2f7338f47c8be7ea49bc691f07a","fc657a42bcbc4ffb8f17f9671361eff1","dd208ba51b5a458fa25ccac5dcc890c1","d618650f493e4b988f644ed65d0f1926","87596b9808c14d0ea1ce89c17e6c1fbe","b6d23c5812b04c1ca279f8f6108d341c","416315da428c4dbc87ad271aac7b363a","3554c0b3c5b44fd89b84a0bc479e75e8","7d40007bee084313be98c8d5faf7e078","6967d07e5ed745d7b7c86540af2123a2","3b89a3dff2cd4cd0a515d180d938b59a","63a65b6cde4f41d5afe7b67bf93684cd","fa03a69513624a1bbb08b8f28d9b5ec6","fa97da75868649d79561c203aa47ac31","f5e4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\\multirow{3}{*}{} & \\multicolumn{4}{|c|}{During the Past} \\\\\n\\hline & \\multicolumn{4}{|l|}{Week} \\\\\n\\hline & Rarely or none of the time (less than 1 day) & Some or a little of the time (1-2 days) & Occasionally or a moderate amount of time (3-4 days) & Most or all of the time (5-7 days) \\\\\n\\hline 1. I was bothered by things that usually don't bother me. & □ & □ & □ & □ \\\\\n\\hline 2. I did not feel like eating; my appetite was poor. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=47\\&width=48\\&top_left_y=916\\&top_left_x=1213) & □ & □ \\\\\n\\hline 3. I felt that I could not shake off the blues even with help from my family or friends. & □ & □ & □ & □ \\\\\n\\hline 4. I felt I was just as good as other people. & □ & □ & □ & □ \\\\\n\\hline 5. I had trouble keeping my mind on what I was doing. & □ & □ & □ & □ \\\\\n\\hline 6. I felt depressed. & □ & □ & □ & □ \\\\\n\\hline 7. I felt that everything I did was an effort. & □ & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1235\\&top_left_x=1462) & □ \\\\\n\\hline 8. I felt hopeful about the future. & □ & □ & □ & □ \\\\\n\\hline 9. I thought my life had been a failure. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=47\\&width=44\\&top_left_y=1332\\&top_left_x=1215) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=42\\&top_left_y=1334\\&top_left_x=1462) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=38\\&width=35\\&top_left_y=1334\\&top_left_x=1713) \\\\\n\\hline 10. I felt fearful. & □ & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=42\\&top_left_y=1376\\&top_left_x=1462) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=37\\&width=40\\&top_left_y=1376\\&top_left_x=1713) \\\\\n\\hline 11. My sleep was restless. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1417\\&top_left_x=1215) & □ & □ \\\\\n\\hline 12. I was happy. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=44\\&width=44\\&top_left_y=1456\\&top_left_x=1215) & □ & □ \\\\\n\\hline 13. I talked less than usual. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1499\\&top_left_x=1215) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=42\\&top_left_y=1499\\&top_left_x=1462) & □ \\\\\n\\hline 14. I felt lonely. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1538\\&top_left_x=1215) & □ & □ \\\\\n\\hline 15. People were unfriendly. & □ & □ & □ & □ \\\\\n\\hline 16. I enjoyed life. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1620\\&top_left_x=1215) & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=40\\&top_left_y=1620\\&top_left_x=1713) \\\\\n\\hline 17. I had crying spells. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1659\\&top_left_x=1215) & □ & □ \\\\\n\\hline 18. I felt sad. & □ & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=47\\&width=44\\&top_left_y=1698\\&top_left_x=1462) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=40\\&top_left_y=1703\\&top_left_x=1713) \\\\\n\\hline 19. I felt that people dislike me. & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=42\\&top_left_y=1742\\&top_left_x=1013) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1742\\&top_left_x=1215) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1742\\&top_left_x=1462) & □ \\\\\n\\hline 20. I could not get \"going.\" & □ & □ & □ & □ \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multirow{3}{*}{} & \\multicolumn{4}{|c|}{During the Past} \\\\\n\\hline & \\multicolumn{4}{|l|}{Week} \\\\\n\\hline & Rarely or none of the time (less than 1 day) & Some or a little of the time (1-2 days) & Occasionally or a moderate amount of time (3-4 days) & Most or all of the time (5-7 days) \\\\\n\\hline 1. I was bothered by things that usually don't bother me. & □ & □ & □ & □ \\\\\n\\hline 2. I did not feel like eating; my appetite was poor. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=47\\&width=48\\&top_left_y=916\\&top_left_x=1213) & □ & □ \\\\\n\\hline 3. I felt that I could not shake off the blues even with help from my family or friends. & □ & □ & □ & □ \\\\\n\\hline 4. I felt I was just as good as other people. & □ & □ & □ & □ \\\\\n\\hline 5. I had trouble keeping my mind on what I was doing. & □ & □ & □ & □ \\\\\n\\hline 6. I felt depressed. & □ & □ & □ & □ \\\\\n\\hline 7. I felt that everything I did was an effort. & □ & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1235\\&top_left_x=1462) & □ \\\\\n\\hline 8. I felt hopeful about the future. & □ & □ & □ & □ \\\\\n\\hline 9. I thought my life had been a failure. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=47\\&width=44\\&top_left_y=1332\\&top_left_x=1215) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=42\\&top_left_y=1334\\&top_left_x=1462) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=38\\&width=35\\&top_left_y=1334\\&top_left_x=1713) \\\\\n\\hline 10. I felt fearful. & □ & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=42\\&top_left_y=1376\\&top_left_x=1462) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=37\\&width=40\\&top_left_y=1376\\&top_left_x=1713) \\\\\n\\hline 11. My sleep was restless. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1417\\&top_left_x=1215) & □ & □ \\\\\n\\hline 12. I was happy. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=44\\&width=44\\&top_left_y=1456\\&top_left_x=1215) & □ & □ \\\\\n\\hline 13. I talked less than usual. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1499\\&top_left_x=1215) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=42\\&top_left_y=1499\\&top_left_x=1462) & □ \\\\\n\\hline 14. I felt lonely. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1538\\&top_left_x=1215) & □ & □ \\\\\n\\hline 15. People were unfriendly. & □ & □ & □ & □ \\\\\n\\hline 16. I enjoyed life. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1620\\&top_left_x=1215) & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=40\\&top_left_y=1620\\&top_left_x=1713) \\\\\n\\hline 17. I had crying spells. & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1659\\&top_left_x=1215) & □ & □ \\\\\n\\hline 18. I felt sad. & □ & □ & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=47\\&width=44\\&top_left_y=1698\\&top_left_x=1462) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=40\\&top_left_y=1703\\&top_left_x=1713) \\\\\n\\hline 19. I felt that people dislike me. & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=42\\&top_left_y=1742\\&top_left_x=1013) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1742\\&top_left_x=1215) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-182.jpg?height=40\\&width=44\\&top_left_y=1742\\&top_left_x=1462) & □ \\\\\n\\hline 20. I could not get \"going.\" & □ & □ & □ & □ 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zero for answers in the first column, 1 for answers in the second column, 2 for answers in the third column, 3 for","text_display":"\n\n\\footnotetext{\nSCORING: zero for answers in the first column, 1 for answers in the second column, 2 for answers in the third column, 3 for","confidence":1,"confidence_rate":1},{"cnt":[[443,1904],[1794,1904],[1794,1936],[443,1936]],"region":{"top_left_x":442,"top_left_y":1903,"width":1352,"height":33},"line":234,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f54b6d13309c4bf1a9daf21f8263691e","type":"text","conversion_output":true,"parent_id":"fa4da68de51048dbb0e2b83ba20099c2","text":"answers in the fourth column. The scoring of positive items is reversed. Possible range of scores is zero to 60 , with the higher","text_display":" answers in the fourth column. The scoring of positive items is reversed. Possible range of scores is zero to 60 , with the higher","confidence":0.947265625,"confidence_rate":0.9996046348627889},{"cnt":[[443,1934],[1051,1934],[1051,1966],[443,1966]],"region":{"top_left_x":442,"top_left_y":1933,"width":609,"height":33},"line":235,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f26f33e11d3f4649bad027cb77c795c9","type":"text","conversion_output":true,"parent_id":"fa4da68de51048dbb0e2b83ba20099c2","text":"scores indicating the presence of more symptomatology.","text_display":" scores indicating the presence of more symptomatology.\n}","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[430,2423],[846,2423],[846,2460],[430,2460]],"region":{"top_left_x":429,"top_left_y":2423,"width":418,"height":37},"line":236,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5e1b6cc78254d94aca6ee50430988f5","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.990257006143338,"confidence_rate":0.9996736943366328},{"cnt":[[432,2462],[849,2462],[849,2494],[432,2494]],"region":{"top_left_x":431,"top_left_y":2462,"width":418,"height":33},"line":237,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a28f806b0cc47bfbb8016a8b2578da2","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1766,2462],[1818,2462],[1818,2505],[1766,2505]],"region":{"top_left_x":1766,"top_left_y":2462,"width":52,"height":44},"line":238,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53b4a6e99cdc472e9b2e20ace9386e0c","type":"page_info","conversion_output":false,"text":"86","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":239,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e21b8c51f61d498aa3050e37e8465aad","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936649702746081,"confidence_rate":0.9999022327614051},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":240,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19fb884960504f148636c861030924ca","type":"page_info","conversion_output":false,"text":"518/aCSR 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7","confidence":1,"confidence_rate":1},{"cnt":[[595,378],[1644,378],[1644,432],[595,432]],"region":{"top_left_x":595,"top_left_y":378,"width":1049,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"555f6d66abea4cc89268b30f0f88fb49","type":"text","conversion_output":true,"parent_id":"a07e49cdf91a4940a0b2624d9f50e915","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":" National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.9358125971630216,"confidence_rate":0.9987945446138229},{"cnt":[[440,455],[1826,455],[1826,1998],[440,1998]],"region":{"top_left_x":440,"top_left_y":455,"width":1387,"height":1544},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3568dae4696042dbbf22f42c2f897d02","type":"table","conversion_output":true,"children_ids":["d7b08ac538bf4be7bd72a25fb642937d","a9e8cead020040679f9a03f451739eb3","41823fa0e80240ed86922520d5cae6e4","d62f236622044c50ad6e55d63478de9a","4d175ef91d06453d882c703581a494e9","2b15214403d845cca646a03d77953e52","50466df34663435b80b64673d58e97da","7aba1d60e2074fee95b861bab1fd0e13","349543a1b1354ef5b52e58d3d26d56d9","8ebb4037297d42e19619d0331f5a28e8","00f3a2ded75e4ba6a8e0bd99ed75861e","296ce91b96444ffe835b3389651f840a","ea453ad500674e97b438089961ff5427","ea6cb0da96b44e648eb778729f3c1808","e0813445baa8499dbf7187ec5b0e8f99","410fef010c424ea7aa3f9bbc53294013","7cc162930b8c4b1dbfac6b3a48f8cbb7","0a1aaea0b0234613bb8bdd8cb57a423f","c75be9f82e7f4918aebd989593c83282","d200918b2998435fada102f1cd1d6660","d568a48d584f48c4963ec6fb412d4da2","33b5152af5814d0a9272794d0f450206","375072919c0541c1b30a353129f24884","347d29f2aa9c47c3bc79ac3f8016e1b2","964a000c6e6e467d954e760d4f1690e5"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|l|}{Administer stroke scale items in the order listed. Record performance in each category after each subscale exam. Do not go back and change scores. Follow directions provided for each exam technique. Scores should reflect what the patent does, not what the clincian thinks the patient can do. The clinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be coached (i.e., repeated requests to patient to make a special effort).} \\\\\n\\hline 1 & Has the subject had a stroke (either as the index event at randomization or as an outcome event)? If no, form is complete. & ◯ No\n◯ Yes \\\\\n\\hline 2 & \\begin{tabular}{l}\n(1a) Level of Consciousness \\\\\nThe investigator must choose a response, even ra ruit evaluation is prevented by such coutacies as an endotracheal hube, language bamer, crotracheal raumabandages. A 3 is soored only if the patient mases no movement (ocher than refexve posturing) in response to noxous stimuation. Coma score \\({ }^{+3}\\).\n\\end{tabular} & ◯ 0=Alert; keenly responsive\n◯ \\(1=\\) Not alert, but arousable by minor stimulation to obey, answer or respond\n◯ \\(2=\\) Not alert, requires repeated stimulation to attend, or is obtunded and requires strong or painful stimulation to make movements (not stereotyped)\n◯ 3=Responds only with reflex motor or autonomic effects or totally unresponsive, flaccid, areflexic (Complete form using coma scoring) \\\\\n\\hline 3 & \\begin{tabular}{l}\n(10) LOC Questions \\\\\nThe pattent is asked the month and his her age. The answer must be correct - There is no partial credit for Deing dose. Aphasic and stuporous patients who do not comprenend the questions will score 2 . Paterits unable to speas because of endotracheal intuoution, orotrachea trauma, severe dysamina from any cause, language barmer or any other problem not secondary to aphasia are glven a i. Ris important that only the nital answer be graded and frot the examiner not \"help\" the pasent with verbal of non-wertal cues. Coma score \\({ }^{+2}\\) \"\n\\end{tabular} & ◯ 0=Answers both questions correctly\n◯ 1=Answers one question correctly\n◯ 2-Answers nether question correctly \\\\\n\\hline 4 & \\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and close the eyes and then to gro and release the non-paretcic hand. substitute another one step command if the hands cannot be used. Credt is given if an unequlvocal attempt is made but not completed due to wealness. If the patlent does not respond to command, the task should be demonstrated to them (pantomine) and score the result (le. follows none, one of two commands). Patients with trauma, amputation, or pther physical impedinents should be given sultable one-steg commands. Ony the frat attenpt is scored. Coma score \"2\".\n\\end{tabular} & ◯ 0=Performs both tasks correctly\n◯ \\(1=\\) Performs one task correctly\n◯ 2=Performs neither task correctly \\\\\n\\hline 5 & \\begin{tabular}{l}\n(2) Best Gaze \\\\\nOnly hontzonta eye movements will be tested. Vountary or reflexve (coulocephails) eye movements will pe scored but calono testing is not obne If the patient has a confugate deviaton of the thes that can be overcome by voluntary or refexlve activing, the score will be i, ir a patent has an isolated peripheral nerve paresis (CV III, IV or VI) score a 1, Gaze is testable in all aphasic patents, Patents wath ocular frauma, bandages, pre-existing bindness or other alsorder of visual aculty or helds should be tested with reflexter movements and a choice made by the investigator. Establishing eye contact and then moving about the patert: from side to side will occassionaly clarly the presence of a partial gaze paisy. Coma score as examined.\n\\end{tabular} & ◯ \\(D =\\) Normal\n◯ 1=Partial gaze palsy. This score is given when gaze is abnormal in one or both eyes, but where forced deviation or total gaze paresis are not present\n◯ 2=Forced deviation, or total gaze paresis not overcome by the oculocephalic maneuver \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|l|}{Administer stroke scale items in the order listed. Record performance in each category after each subscale exam. Do not go back and change scores. Follow directions provided for each exam technique. Scores should reflect what the patent does, not what the clincian thinks the patient can do. The clinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be coached (i.e., repeated requests to patient to make a special effort).} \\\\\n\\hline 1 & Has the subject had a stroke (either as the index event at randomization or as an outcome event)? If no, form is complete. & ◯ No\n◯ Yes \\\\\n\\hline 2 & \\begin{tabular}{l}\n(1a) Level of Consciousness \\\\\nThe investigator must choose a response, even ra ruit evaluation is prevented by such coutacies as an endotracheal hube, language bamer, crotracheal raumabandages. A 3 is soored only if the patient mases no movement (ocher than refexve posturing) in response to noxous stimuation. Coma score \\({ }^{+3}\\).\n\\end{tabular} & ◯ 0=Alert; keenly responsive\n◯ \\(1=\\) Not alert, but arousable by minor stimulation to obey, answer or respond\n◯ \\(2=\\) Not alert, requires repeated stimulation to attend, or is obtunded and requires strong or painful stimulation to make movements (not stereotyped)\n◯ 3=Responds only with reflex motor or autonomic effects or totally unresponsive, flaccid, areflexic (Complete form using coma scoring) \\\\\n\\hline 3 & \\begin{tabular}{l}\n(10) LOC Questions \\\\\nThe pattent is asked the month and his her age. The answer must be correct - There is no partial credit for Deing dose. Aphasic and stuporous patients who do not comprenend the questions will score 2 . Paterits unable to speas because of endotracheal intuoution, orotrachea trauma, severe dysamina from any cause, language barmer or any other problem not secondary to aphasia are glven a i. Ris important that only the nital answer be graded and frot the examiner not \"help\" the pasent with verbal of non-wertal cues. Coma score \\({ }^{+2}\\) \"\n\\end{tabular} & ◯ 0=Answers both questions correctly\n◯ 1=Answers one question correctly\n◯ 2-Answers nether question correctly \\\\\n\\hline 4 & \\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and close the eyes and then to gro and release the non-paretcic hand. substitute another one step command if the hands cannot be used. Credt is given if an unequlvocal attempt is made but not completed due to wealness. If the patlent does not respond to command, the task should be demonstrated to them (pantomine) and score the result (le. follows none, one of two commands). Patients with trauma, amputation, or pther physical impedinents should be given sultable one-steg commands. Ony the frat attenpt is scored. Coma score \"2\".\n\\end{tabular} & ◯ 0=Performs both tasks correctly\n◯ \\(1=\\) Performs one task correctly\n◯ 2=Performs neither task correctly \\\\\n\\hline 5 & \\begin{tabular}{l}\n(2) Best Gaze \\\\\nOnly hontzonta eye movements will be tested. Vountary or reflexve (coulocephails) eye movements will pe scored but calono testing is not obne If the patient has a confugate deviaton of the thes that can be overcome by voluntary or refexlve activing, the score will be i, ir a patent has an isolated peripheral nerve paresis (CV III, IV or VI) score a 1, Gaze is testable in all aphasic patents, Patents wath ocular frauma, bandages, pre-existing bindness or other alsorder of visual aculty or helds should be tested with reflexter movements and a choice made by the investigator. Establishing eye contact and then moving about the patert: from side to side will occassionaly clarly the presence of a partial gaze paisy. 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LOC Questions \\\\\nThe pattent is asked the month and his her age. The answer must be correct - There is no partial credit for Deing dose. Aphasic and stuporous patients who do not comprenend the questions will score 2 . Paterits unable to speas because of endotracheal intuoution, orotrachea trauma, severe dysamina from any cause, language barmer or any other problem not secondary to aphasia are glven a i. Ris important that only the nital answer be graded and frot the examiner not \"help\" the pasent with verbal of non-wertal cues. Coma score \\({ }^{+2}\\) \"\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(10) LOC Questions \\\\\nThe pattent is asked the month and his her age. The answer must be correct - There is no partial credit for Deing dose. Aphasic and stuporous patients who do not comprenend the questions will score 2 . Paterits unable to speas because of endotracheal intuoution, orotrachea trauma, severe dysamina from any cause, language barmer or any other problem not secondary to aphasia are glven a i. Ris important that only the nital answer be graded and frot the examiner not \"help\" the pasent with verbal of non-wertal cues. 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The answer must be correct","text_display":"\nThe pattent is asked the month and his her age. The answer must be correct","confidence":0.33877440063575315,"confidence_rate":0.9863919086244889},{"cnt":[[538,1216],[1132,1216],[1132,1239],[538,1239]],"region":{"top_left_x":538,"top_left_y":1216,"width":594,"height":24},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"edc19bb3cd074fa2a4104e75184191f7","type":"text","conversion_output":false,"parent_id":"0a1aaea0b0234613bb8bdd8cb57a423f","text":"- There is no partial credit for Deing dose. Aphasic and stuporous patients","text_display":" - There is no partial credit for Deing dose. 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Ris important that only the nital answer be graded","text_display":" aphasia are glven a i. 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LOC Commands \\\\\nThe patent is asked to open and close the eyes and then to gro and release the non-paretcic hand. substitute another one step command if the hands cannot be used. Credt is given if an unequlvocal attempt is made but not completed due to wealness. If the patlent does not respond to command, the task should be demonstrated to them (pantomine) and score the result (le. follows none, one of two commands). Patients with trauma, amputation, or pther physical impedinents should be given sultable one-steg commands. Ony the frat attenpt is scored. Coma score \"2\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and close the eyes and then to gro and release the non-paretcic hand. substitute another one step command if the hands cannot be used. Credt is given if an unequlvocal attempt is made but not completed due to wealness. If the patlent does not respond to command, the task should be demonstrated to them (pantomine) and score the result (le. follows none, one of two commands). Patients with trauma, amputation, or pther physical impedinents should be given sultable one-steg commands. Ony the frat attenpt is scored. Coma score \"2\".\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.09229653571463294,"confidence_rate":0.9865350185173875},{"cnt":[[732,1450],[732,1419],[940,1421],[939,1452]],"region":{"top_left_x":731,"top_left_y":1418,"width":209,"height":34},"line":72,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5df1e4bf38d4417ab664f2c14b558084","type":"text","conversion_output":false,"parent_id":"d568a48d584f48c4963ec6fb412d4da2","text":"(1c) LOC Commands","text_display":"(1c) LOC Commands","confidence":0.9819836616516113,"confidence_rate":0.9991739500674586},{"cnt":[[523,1467],[1145,1467],[1145,1493],[523,1493]],"region":{"top_left_x":523,"top_left_y":1467,"width":623,"height":27},"line":73,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1ac805ae4d4845e39662bd290cb61861","type":"text","conversion_output":false,"parent_id":"d568a48d584f48c4963ec6fb412d4da2","text":"The patent is asked to open and close the eyes and then to gro and release","text_display":"\nThe patent is asked to open and close the eyes and then to gro and release","confidence":0.7683907894315388,"confidence_rate":0.9966706579478359},{"cnt":[[541,1492],[1129,1492],[1129,1515],[541,1515]],"region":{"top_left_x":540,"top_left_y":1491,"width":589,"height":24},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d1cb5c855f3d46648efa202446560bcb","type":"text","conversion_output":false,"parent_id":"d568a48d584f48c4963ec6fb412d4da2","text":"the non-paretcic hand. substitute another one step command if the hands","text_display":" the non-paretcic hand. substitute another one step command if the hands","confidence":0.09229653571463294,"confidence_rate":0.9691344201780335},{"cnt":[[541,1511],[1132,1511],[1132,1534],[541,1534]],"region":{"top_left_x":540,"top_left_y":1510,"width":592,"height":25},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2675229ec47f471bacc140ee4026a5c2","type":"text","conversion_output":false,"parent_id":"d568a48d584f48c4963ec6fb412d4da2","text":"cannot be used. Credt is given if an unequlvocal attempt is made but not","text_display":" cannot be used. Credt is given if an unequlvocal attempt is made but not","confidence":0.9006916896544426,"confidence_rate":0.9986425810007777},{"cnt":[[523,1530],[1148,1530],[1148,1556],[523,1556]],"region":{"top_left_x":523,"top_left_y":1529,"width":626,"height":27},"line":76,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"023b9ca7b4664c5ba029b6a08adf397a","type":"text","conversion_output":false,"parent_id":"d568a48d584f48c4963ec6fb412d4da2","text":"completed due to wealness. If the patlent does not respond to command, the","text_display":" completed due to wealness. If the patlent does not respond to command, the","confidence":0.19142570505738127,"confidence_rate":0.9792901711423632},{"cnt":[[525,1553],[1143,1553],[1143,1578],[525,1578]],"region":{"top_left_x":524,"top_left_y":1553,"width":619,"height":25},"line":77,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"33a0d430363749efbeae335d255bc672","type":"text","conversion_output":false,"parent_id":"d568a48d584f48c4963ec6fb412d4da2","text":"task should be demonstrated to them (pantomine) and score the result (le.","text_display":" task should be demonstrated to them (pantomine) and score the result (le.","confidence":0.21805334839235802,"confidence_rate":0.9806635544051916},{"cnt":[[533,1574],[1140,1574],[1140,1598],[533,1598]],"region":{"top_left_x":532,"top_left_y":1573,"width":608,"height":26},"line":78,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4ce39a9e47d94ff79eb4193a755636e6","type":"text","conversion_output":false,"parent_id":"d568a48d584f48c4963ec6fb412d4da2","text":"follows none, one of two commands). Patients with trauma, amputation, or","text_display":" follows none, one of two commands). Patients with trauma, amputation, or","confidence":0.35835586659558516,"confidence_rate":0.9867607737832741},{"cnt":[[535,1595],[1134,1595],[1134,1619],[535,1619]],"region":{"top_left_x":535,"top_left_y":1595,"width":600,"height":24},"line":79,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0d0e8d63b211498fa188cec7a1715bdf","type":"text","conversion_output":false,"parent_id":"d568a48d584f48c4963ec6fb412d4da2","text":"pther physical impedinents should be given sultable one-steg commands.","text_display":" pther physical impedinents should be given sultable one-steg commands.","confidence":0.33202716703813956,"confidence_rate":0.9854070118742931},{"cnt":[[634,1615],[1038,1615],[1038,1640],[634,1640]],"region":{"top_left_x":633,"top_left_y":1614,"width":405,"height":27},"line":80,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"58e6c3e083314feca1dab20a36e9b7d5","type":"text","conversion_output":false,"parent_id":"d568a48d584f48c4963ec6fb412d4da2","text":"Ony the frat attenpt is scored. Coma score \"2\".","text_display":" Ony the frat attenpt is scored. Coma score \"2\".","confidence":0.42060026396922134,"confidence_rate":0.9834826934241886},{"cnt":[[1158,1464],[1511,1464],[1511,1602],[1158,1602]],"region":{"top_left_x":1157,"top_left_y":1464,"width":354,"height":139},"line":81,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"33b5152af5814d0a9272794d0f450206","type":"complex_cell","conversion_output":false,"parent_id":"3568dae4696042dbbf22f42c2f897d02","children_ids":["ee5484e0d7c641a0b6be41c0390f70b0","245b879a6333422caa184195672fda6e","c67cc0f86ef049a19570a7eb145b72c5","49910fc4c5f44ac6be3377ec0df39fbd","a825a49308314571beb4edc9485073b7","c8ad84db773e41f7a086e3c4e6ab9fb6"],"text":"◯ 0=Performs both tasks correctly\n◯ \\(1=\\) Performs one task correctly\n◯ 2=Performs neither task correctly","text_display":"◯ 0=Performs both tasks correctly\n◯ \\(1=\\) Performs one task correctly\n◯ 2=Performs neither task correctly","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.742615552037023,"confidence_rate":0.9965318957158261},{"cnt":[[1160,1467],[1197,1467],[1197,1504],[1160,1504]],"region":{"top_left_x":1160,"top_left_y":1467,"width":38,"height":38},"line":82,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ee5484e0d7c641a0b6be41c0390f70b0","type":"form_field","conversion_output":false,"parent_id":"33b5152af5814d0a9272794d0f450206","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1196,1477],[1495,1477],[1495,1507],[1196,1507]],"region":{"top_left_x":1195,"top_left_y":1476,"width":300,"height":31},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"245b879a6333422caa184195672fda6e","type":"text","conversion_output":false,"parent_id":"33b5152af5814d0a9272794d0f450206","text":"0=Performs both tasks correctly","text_display":" 0=Performs both tasks correctly","confidence":0.9425188705790788,"confidence_rate":0.9983569252714329},{"cnt":[[1160,1511],[1197,1511],[1197,1548],[1160,1548]],"region":{"top_left_x":1160,"top_left_y":1510,"width":38,"height":38},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c67cc0f86ef049a19570a7eb145b72c5","type":"form_field","conversion_output":false,"parent_id":"33b5152af5814d0a9272794d0f450206","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1198,1522],[1479,1522],[1479,1552],[1198,1552]],"region":{"top_left_x":1198,"top_left_y":1521,"width":282,"height":31},"line":85,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"49910fc4c5f44ac6be3377ec0df39fbd","type":"text","conversion_output":false,"parent_id":"33b5152af5814d0a9272794d0f450206","text":"\\(1=\\) Performs one task correctly","text_display":" \\(1=\\) Performs one task correctly","confidence":0.742615552037023,"confidence_rate":0.9912859308500049},{"cnt":[[1160,1557],[1196,1557],[1196,1594],[1160,1594]],"region":{"top_left_x":1160,"top_left_y":1557,"width":36,"height":38},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a825a49308314571beb4edc9485073b7","type":"form_field","conversion_output":false,"parent_id":"33b5152af5814d0a9272794d0f450206","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1196,1568],[1508,1568],[1508,1597],[1196,1597]],"region":{"top_left_x":1195,"top_left_y":1568,"width":314,"height":29},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c8ad84db773e41f7a086e3c4e6ab9fb6","type":"text","conversion_output":false,"parent_id":"33b5152af5814d0a9272794d0f450206","text":"2=Performs neither task correctly","text_display":" 2=Performs neither task correctly","confidence":0.9990234375,"confidence_rate":0.9999742887608599},{"cnt":[[473,1816],[492,1816],[492,1849],[473,1849]],"region":{"top_left_x":472,"top_left_y":1816,"width":20,"height":34},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"375072919c0541c1b30a353129f24884","type":"simple_cell","conversion_output":false,"parent_id":"3568dae4696042dbbf22f42c2f897d02","text":"5","text_display":"5","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[522,1696],[1148,1696],[1148,1967],[522,1967]],"region":{"top_left_x":521,"top_left_y":1696,"width":628,"height":271},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"347d29f2aa9c47c3bc79ac3f8016e1b2","type":"complex_cell","conversion_output":false,"parent_id":"3568dae4696042dbbf22f42c2f897d02","children_ids":["484608eab05a42e48427336622b7ad73","017446f35a104fd49db954dcacff469c","2f8457d19a114dcb8847b377a3a65b3c","2254f21e9534422d8460fb1a84143f46","05045ce6f1b340f3a0de636685108ef1","87eddd74fd474e0e91fb60ecbebac998","cd04c7c753314ca7906bc0cd049b4c0b","bab1b35977c444b7bfe5e5de82c7d15b","5cbf544e1eeb45bda0f136b549f0c4c2","88efdfd8c1e2476c8ac3581ae22493d5","a15eb0d55c834135885e9e778dfa70a3"],"text":"\\begin{tabular}{l}\n(2) Best Gaze \\\\\nOnly hontzonta eye movements will be tested. Vountary or reflexve (coulocephails) eye movements will pe scored but calono testing is not obne If the patient has a confugate deviaton of the thes that can be overcome by voluntary or refexlve activing, the score will be i, ir a patent has an isolated peripheral nerve paresis (CV III, IV or VI) score a 1, Gaze is testable in all aphasic patents, Patents wath ocular frauma, bandages, pre-existing bindness or other alsorder of visual aculty or helds should be tested with reflexter movements and a choice made by the investigator. Establishing eye contact and then moving about the patert: from side to side will occassionaly clarly the presence of a partial gaze paisy. Coma score as examined.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(2) Best Gaze \\\\\nOnly hontzonta eye movements will be tested. Vountary or reflexve (coulocephails) eye movements will pe scored but calono testing is not obne If the patient has a confugate deviaton of the thes that can be overcome by voluntary or refexlve activing, the score will be i, ir a patent has an isolated peripheral nerve paresis (CV III, IV or VI) score a 1, Gaze is testable in all aphasic patents, Patents wath ocular frauma, bandages, pre-existing bindness or other alsorder of visual aculty or helds should be tested with reflexter movements and a choice made by the investigator. Establishing eye contact and then moving about the patert: from side to side will occassionaly clarly the presence of a partial gaze paisy. Coma score as examined.\n\\end{tabular}","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.015971562625641055,"confidence_rate":0.9702592477746569},{"cnt":[[762,1699],[911,1699],[911,1729],[762,1729]],"region":{"top_left_x":761,"top_left_y":1699,"width":150,"height":31},"line":90,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"484608eab05a42e48427336622b7ad73","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"(2) Best Gaze","text_display":"(2) Best Gaze","confidence":0.86962890625,"confidence_rate":0.9922695513141633},{"cnt":[[560,1748],[1111,1748],[1111,1771],[560,1771]],"region":{"top_left_x":560,"top_left_y":1748,"width":552,"height":24},"line":91,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"017446f35a104fd49db954dcacff469c","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"Only hontzonta eye movements will be tested. Vountary or reflexve","text_display":"\nOnly hontzonta eye movements will be tested. Vountary or reflexve","confidence":0.023161610374957387,"confidence_rate":0.9476316418768082},{"cnt":[[525,1767],[1143,1767],[1143,1793],[525,1793]],"region":{"top_left_x":524,"top_left_y":1767,"width":619,"height":27},"line":92,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2f8457d19a114dcb8847b377a3a65b3c","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"(coulocephails) eye movements will pe scored but calono testing is not obne","text_display":" (coulocephails) eye movements will pe scored but calono testing is not obne","confidence":0.015971562625641055,"confidence_rate":0.9496024853552366},{"cnt":[[527,1789],[1143,1789],[1143,1815],[527,1815]],"region":{"top_left_x":527,"top_left_y":1789,"width":616,"height":27},"line":93,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2254f21e9534422d8460fb1a84143f46","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"If the patient has a confugate deviaton of the thes that can be overcome by","text_display":" If the patient has a confugate deviaton of the thes that can be overcome by","confidence":0.12681792008050113,"confidence_rate":0.9745177589790487},{"cnt":[[530,1811],[1140,1811],[1140,1837],[530,1837]],"region":{"top_left_x":530,"top_left_y":1810,"width":610,"height":27},"line":94,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"05045ce6f1b340f3a0de636685108ef1","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"voluntary or refexlve activing, the score will be i, ir a patent has an isolated","text_display":" voluntary or refexlve activing, the score will be i, ir a patent has an isolated","confidence":0.0414484726318832,"confidence_rate":0.9632419639098694},{"cnt":[[535,1833],[1134,1833],[1134,1859],[535,1859]],"region":{"top_left_x":535,"top_left_y":1832,"width":600,"height":27},"line":95,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"87eddd74fd474e0e91fb60ecbebac998","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"peripheral nerve paresis (CV III, IV or VI) score a 1, Gaze is testable in all","text_display":" peripheral nerve paresis (CV III, IV or VI) score a 1, Gaze is testable in all","confidence":0.3660432089410609,"confidence_rate":0.9879645319974402},{"cnt":[[555,1855],[1115,1855],[1115,1879],[555,1879]],"region":{"top_left_x":554,"top_left_y":1854,"width":562,"height":26},"line":96,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cd04c7c753314ca7906bc0cd049b4c0b","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"aphasic patents, Patents wath ocular frauma, bandages, pre-existing","text_display":" aphasic patents, Patents wath ocular frauma, bandages, pre-existing","confidence":0.10246589095571018,"confidence_rate":0.9688533519201464},{"cnt":[[541,1874],[1130,1874],[1130,1897],[541,1897]],"region":{"top_left_x":540,"top_left_y":1873,"width":591,"height":24},"line":97,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bab1b35977c444b7bfe5e5de82c7d15b","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"bindness or other alsorder of visual aculty or helds should be tested with","text_display":" bindness or other alsorder of visual aculty or helds should be tested with","confidence":0.10060987771140255,"confidence_rate":0.9713487770728403},{"cnt":[[523,1896],[1147,1896],[1147,1919],[523,1919]],"region":{"top_left_x":523,"top_left_y":1895,"width":624,"height":24},"line":98,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5cbf544e1eeb45bda0f136b549f0c4c2","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"reflexter movements and a choice made by the investigator. Establishing eye","text_display":" reflexter movements and a choice made by the investigator. Establishing eye","confidence":0.0766410842260196,"confidence_rate":0.9684022069260534},{"cnt":[[527,1917],[1143,1917],[1143,1942],[527,1942]],"region":{"top_left_x":527,"top_left_y":1917,"width":616,"height":25},"line":99,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"88efdfd8c1e2476c8ac3581ae22493d5","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"contact and then moving about the patert: from side to side will occassionaly","text_display":" contact and then moving about the patert: from side to side will occassionaly","confidence":0.10661968058879447,"confidence_rate":0.9730706159477938},{"cnt":[[546,1936],[1123,1936],[1123,1962],[546,1962]],"region":{"top_left_x":546,"top_left_y":1936,"width":578,"height":27},"line":100,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a15eb0d55c834135885e9e778dfa70a3","type":"text","conversion_output":false,"parent_id":"347d29f2aa9c47c3bc79ac3f8016e1b2","text":"clarly the presence of a partial gaze paisy. Coma score as examined.","text_display":" clarly the presence of a partial gaze paisy. Coma score as examined.","confidence":0.1817177775333186,"confidence_rate":0.9769104586839502},{"cnt":[[1158,1729],[1803,1729],[1803,1941],[1158,1941]],"region":{"top_left_x":1157,"top_left_y":1729,"width":646,"height":212},"line":101,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"964a000c6e6e467d954e760d4f1690e5","type":"complex_cell","conversion_output":false,"parent_id":"3568dae4696042dbbf22f42c2f897d02","children_ids":["5d5956ef0c2c4f34b37004170a629a9a","b9f33bf6e6404c86985be62f74789785","db6801c571fe4d93956eebc2ac600e29","a18f37896f4440bebd958c348114d991","46bbf0b5a9b144ebb092116494f72cdc","1a48334fcd75498497240f3cc8a8b847","9a63e5e71f5a429397c3741c6f91037a","62c8dc9d59324b299efb6d88c0111c4d","e395400d8f9847929ae0fbdef4b79ead"],"text":"◯ \\(D =\\) Normal\n◯ 1=Partial gaze palsy. This score is given when gaze is abnormal in one or both eyes, but where forced deviation or total gaze paresis are not present\n◯ 2=Forced deviation, or total gaze paresis not overcome by the oculocephalic maneuver","text_display":"◯ \\(D =\\) Normal\n◯ 1=Partial gaze palsy. This score is given when gaze is abnormal in one or both eyes, but where forced deviation or total gaze paresis are not present\n◯ 2=Forced deviation, or total gaze paresis not overcome by the oculocephalic maneuver","cell_row":5,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.5355516135427371,"confidence_rate":0.9927639051674259},{"cnt":[[1160,1732],[1197,1732],[1197,1769],[1160,1769]],"region":{"top_left_x":1160,"top_left_y":1731,"width":38,"height":38},"line":102,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5d5956ef0c2c4f34b37004170a629a9a","type":"form_field","conversion_output":false,"parent_id":"964a000c6e6e467d954e760d4f1690e5","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1196,1743],[1293,1743],[1293,1769],[1196,1769]],"region":{"top_left_x":1195,"top_left_y":1742,"width":98,"height":27},"line":103,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b9f33bf6e6404c86985be62f74789785","type":"text","conversion_output":false,"parent_id":"964a000c6e6e467d954e760d4f1690e5","text":"\\(D =\\) Normal","text_display":" \\(D =\\) Normal","confidence":0.5355516135427371,"confidence_rate":0.9617231788309327},{"cnt":[[1160,1776],[1197,1776],[1197,1811],[1160,1811]],"region":{"top_left_x":1160,"top_left_y":1775,"width":38,"height":36},"line":104,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"db6801c571fe4d93956eebc2ac600e29","type":"form_field","conversion_output":false,"parent_id":"964a000c6e6e467d954e760d4f1690e5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1198,1784],[1803,1784],[1803,1815],[1198,1815]],"region":{"top_left_x":1198,"top_left_y":1783,"width":605,"height":33},"line":105,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a18f37896f4440bebd958c348114d991","type":"text","conversion_output":false,"parent_id":"964a000c6e6e467d954e760d4f1690e5","text":"1=Partial gaze palsy. This score is given when gaze is abnormal","text_display":" 1=Partial gaze palsy. This score is given when gaze is abnormal","confidence":0.7430458611997892,"confidence_rate":0.9956419136718663},{"cnt":[[1228,1814],[1786,1814],[1786,1842],[1228,1842]],"region":{"top_left_x":1228,"top_left_y":1813,"width":559,"height":30},"line":106,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"46bbf0b5a9b144ebb092116494f72cdc","type":"text","conversion_output":false,"parent_id":"964a000c6e6e467d954e760d4f1690e5","text":"in one or both eyes, but where forced deviation or total gaze","text_display":" in one or both eyes, but where forced deviation or total gaze","confidence":0.9887919342145324,"confidence_rate":0.9998292365596533},{"cnt":[[1228,1841],[1448,1841],[1448,1867],[1228,1867]],"region":{"top_left_x":1228,"top_left_y":1840,"width":221,"height":27},"line":107,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1a48334fcd75498497240f3cc8a8b847","type":"text","conversion_output":false,"parent_id":"964a000c6e6e467d954e760d4f1690e5","text":"paresis are not present","text_display":" paresis are not present","confidence":1,"confidence_rate":1},{"cnt":[[1160,1870],[1196,1870],[1196,1905],[1160,1905]],"region":{"top_left_x":1160,"top_left_y":1869,"width":36,"height":37},"line":108,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9a63e5e71f5a429397c3741c6f91037a","type":"form_field","conversion_output":false,"parent_id":"964a000c6e6e467d954e760d4f1690e5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1196,1878],[1773,1878],[1773,1908],[1196,1908]],"region":{"top_left_x":1195,"top_left_y":1877,"width":578,"height":31},"line":109,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"62c8dc9d59324b299efb6d88c0111c4d","type":"text","conversion_output":false,"parent_id":"964a000c6e6e467d954e760d4f1690e5","text":"2=Forced deviation, or total gaze paresis not overcome by the","text_display":" 2=Forced deviation, or total gaze paresis not overcome by the","confidence":0.99951171875,"confidence_rate":0.9999926000198329},{"cnt":[[1218,1906],[1448,1906],[1448,1935],[1218,1935]],"region":{"top_left_x":1217,"top_left_y":1906,"width":232,"height":30},"line":110,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e395400d8f9847929ae0fbdef4b79ead","type":"text","conversion_output":false,"parent_id":"964a000c6e6e467d954e760d4f1690e5","text":"oculocephalic maneuver","text_display":" oculocephalic maneuver","confidence":1,"confidence_rate":1},{"cnt":[[425,2419],[849,2419],[849,2464],[425,2464]],"region":{"top_left_x":425,"top_left_y":2419,"width":424,"height":46},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c99c449d483412cb93169c08f3ad5ac","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999837201159151},{"cnt":[[430,2458],[849,2458],[849,2499],[430,2499]],"region":{"top_left_x":429,"top_left_y":2457,"width":420,"height":42},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"138c47e34c654ae2b302d9563c2bd234","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1764,2458],[1818,2458],[1818,2505],[1764,2505]],"region":{"top_left_x":1763,"top_left_y":2457,"width":55,"height":49},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e80570df7b564ecca451a96226a53f1e","type":"page_info","conversion_output":false,"text":"87","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f77963dcbd524db49cd331acc34b6c91","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936649702746081,"confidence_rate":0.9999022327614051},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":115,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db0aedb175f94430a6657c0cf7283d8d","type":"page_info","conversion_output":false,"text":"519/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-184","page":184,"lines":[{"cnt":[[589,329],[1652,329],[1652,438],[589,438]],"region":{"top_left_x":588,"top_left_y":328,"width":1065,"height":111},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1f77adc69744c90ab20a06c4154a648","type":"section_header","conversion_output":false,"children_ids":["5bc9f28279024ab09443edff2e709865","b50c8632e2564c0cb208d74758935ffd"],"text":"","text_display":""},{"cnt":[[920,335],[1317,335],[1317,385],[920,385]],"region":{"top_left_x":919,"top_left_y":335,"width":398,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bc9f28279024ab09443edff2e709865","type":"text","conversion_output":true,"parent_id":"a1f77adc69744c90ab20a06c4154a648","text":"Appendix 7 (cont.)","text_display":"\n\n\\section*{Appendix 7 (cont.)","confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[593,378],[1646,378],[1646,432],[593,432]],"region":{"top_left_x":592,"top_left_y":378,"width":1054,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b50c8632e2564c0cb208d74758935ffd","type":"text","conversion_output":true,"parent_id":"a1f77adc69744c90ab20a06c4154a648","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":" National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.9678746829740703,"confidence_rate":0.999406491471838},{"cnt":[[434,483],[1841,483],[1841,2039],[434,2039]],"region":{"top_left_x":433,"top_left_y":483,"width":1409,"height":1556},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"82f903c43133435cb39f77294be11554","type":"table","conversion_output":true,"children_ids":["0ccb5e8d3e7f46af913843ba28696eea","eb62fda06fa54522b86e45a6524508ca","1c8f17d0be5e4aeda10b148a26657bd8","da62bfb095f9481dade7a0b84d352059","f7059aae73ea402c93b6fcf121c004ca","676e3aa8f7b345e6b1d634a848014514","2f455f9328e642208ea6026f6c2e9d55","b11fae70b6bf4f1eacfec36bac135064","8e842803a1e44540af537cab3fa95e4e","a149c0952fe746dbbab40b6e3a3ce3e9","def8d952acec4f66a3df783cf13d9209","163743b92d7848f293ca240787d90543","81a3023743714044b7add2392d1c746e","c7ed1b21b1a3469da32d37a9bba153d9","593e66f7972142b0b8a9b001e5f03362","2cd1ee0612e34bed85ea7d052e68e531","daa2e4cf4ff24aa5a7c5882018486dd5","12c63b0c9c4048a3b15e30353b0cf5b0","53911521c70648c18a7e9b8b32a33cd2","a3c0b00236944f18b733907ee0418c28","97f69a0ccba04b6cb6c092def3148507","75061287761e41709710a129a7cc262f","79cf3526fa49450c9f358bd21e0eeae2","ef95bf8cb8fe46718a3d381a5a80c147","3e868add73034f168a62b0d8bd821069"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline 8 & \\begin{tabular}{l}\n(3) Visual \\\\\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, out if they look at the side of the moving fingers appropriately, this can be scored as normal. It there is unliateral bilndness or enucleaton, visual flads in the remaining eye are scored. Score 1 only If a clear-cut asymmetry, Including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous stimulaton is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22. Score as examined, using bilateral threat.\n\\end{tabular} & ◯ 0=No visual loss\n◯ \\(1=\\) Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral hemianopia (blind including cortical blindness) \\\\\n\\hline 7 & Ask, or use pantomine to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responsive or non-comprehending patent. If facial traumalbandages, orotracheal tuipe, tape or other physical bamier obscures the face, these should be removed to the extent possible. Coma Score \"3\". & ◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face) \\\\\n\\hline 8 & \\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fuston at the shouder or hip can the examiner indicate no score and an explanation must be provided. \\\\\nComa Score \"4\"\n\\end{tabular} & ◯ \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 9 & Explain if amputation or joint fusion (Motor Arm Left): & \\\\\n\\hline 10 & \\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm tals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomine but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fuslon at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ \\(0=\\) No drift, limb holds 90 (or 45 ) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 11 & Explain if amputation or joint fusion (Motor Arm Right): & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 8 & \\begin{tabular}{l}\n(3) Visual \\\\\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, out if they look at the side of the moving fingers appropriately, this can be scored as normal. It there is unliateral bilndness or enucleaton, visual flads in the remaining eye are scored. Score 1 only If a clear-cut asymmetry, Including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous stimulaton is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22. Score as examined, using bilateral threat.\n\\end{tabular} & ◯ 0=No visual loss\n◯ \\(1=\\) Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral hemianopia (blind including cortical blindness) \\\\\n\\hline 7 & Ask, or use pantomine to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responsive or non-comprehending patent. If facial traumalbandages, orotracheal tuipe, tape or other physical bamier obscures the face, these should be removed to the extent possible. Coma Score \"3\". & ◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face) \\\\\n\\hline 8 & \\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fuston at the shouder or hip can the examiner indicate no score and an explanation must be provided. \\\\\nComa Score \"4\"\n\\end{tabular} & ◯ \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 9 & Explain if amputation or joint fusion (Motor Arm Left): & \\\\\n\\hline 10 & \\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm tals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomine but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fuslon at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ \\(0=\\) No drift, limb holds 90 (or 45 ) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 11 & Explain if amputation or joint fusion (Motor Arm Right): & 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Visual \\\\\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, out if they look at the side of the moving fingers appropriately, this can be scored as normal. It there is unliateral bilndness or enucleaton, visual flads in the remaining eye are scored. Score 1 only If a clear-cut asymmetry, Including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous stimulaton is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22. Score as examined, using bilateral threat.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(3) Visual \\\\\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, out if they look at the side of the moving fingers appropriately, this can be scored as normal. It there is unliateral bilndness or enucleaton, visual flads in the remaining eye are scored. Score 1 only If a clear-cut asymmetry, Including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous stimulaton is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22. Score as examined, using bilateral threat.\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.20474953983097496,"confidence_rate":0.9908889631822385},{"cnt":[[804,508],[912,508],[912,535],[804,535]],"region":{"top_left_x":804,"top_left_y":507,"width":108,"height":28},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2577185e48334fc2ab18091ebc279427","type":"text","conversion_output":false,"parent_id":"def8d952acec4f66a3df783cf13d9209","text":"(3) Visual","text_display":"(3) Visual","confidence":1,"confidence_rate":1},{"cnt":[[518,557],[1185,557],[1185,581],[518,581]],"region":{"top_left_x":517,"top_left_y":556,"width":668,"height":26},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f4ea80f3b553444bb3bbdb830325f2bb","type":"text","conversion_output":false,"parent_id":"def8d952acec4f66a3df783cf13d9209","text":"Visual fields (upper and lower quadrants) are tested by confrontation, using finger","text_display":"\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger","confidence":0.7659850220411228,"confidence_rate":0.9969751221114115},{"cnt":[[518,578],[1168,578],[1168,602],[518,602]],"region":{"top_left_x":517,"top_left_y":578,"width":652,"height":24},"line":18,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0fd57120f3864d08a948306a9de67170","type":"text","conversion_output":false,"parent_id":"def8d952acec4f66a3df783cf13d9209","text":"counting or wsual threat as appropriate. Patient must be encouraged, out if they","text_display":" counting or wsual threat as appropriate. Patient must be encouraged, out if they","confidence":0.21385105781438105,"confidence_rate":0.9820168906094434},{"cnt":[[518,598],[1198,598],[1198,621],[518,621]],"region":{"top_left_x":517,"top_left_y":597,"width":682,"height":24},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"242a165fd8d84d7fab31959b2b0efd98","type":"text","conversion_output":false,"parent_id":"def8d952acec4f66a3df783cf13d9209","text":"look at the side of the moving fingers appropriately, this can be scored as normal. It","text_display":" look at the side of the moving fingers appropriately, this can be scored as normal. It","confidence":0.30164348857795065,"confidence_rate":0.9869159170232825},{"cnt":[[518,619],[1172,619],[1172,643],[518,643]],"region":{"top_left_x":517,"top_left_y":619,"width":656,"height":24},"line":20,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"35f2fa7c5bc14f45bc94262d6a5c4f9c","type":"text","conversion_output":false,"parent_id":"def8d952acec4f66a3df783cf13d9209","text":"there is unliateral bilndness or enucleaton, visual flads in the remaining eye are","text_display":" there is unliateral bilndness or enucleaton, visual flads in the remaining eye are","confidence":0.2598232760427116,"confidence_rate":0.9846279542959386},{"cnt":[[518,641],[1198,641],[1198,666],[518,666]],"region":{"top_left_x":517,"top_left_y":641,"width":682,"height":25},"line":21,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9f5fc085af8b4467b8e023a7d41278c0","type":"text","conversion_output":false,"parent_id":"def8d952acec4f66a3df783cf13d9209","text":"scored. Score 1 only If a clear-cut asymmetry, Including quadrantanopla is found. If","text_display":" scored. Score 1 only If a clear-cut asymmetry, Including quadrantanopla is found. If","confidence":0.20474953983097496,"confidence_rate":0.9829089571439797},{"cnt":[[516,663],[1127,663],[1127,686],[516,686]],"region":{"top_left_x":516,"top_left_y":663,"width":612,"height":24},"line":22,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"26325ccf7bf344929558f726c01c4b2e","type":"text","conversion_output":false,"parent_id":"def8d952acec4f66a3df783cf13d9209","text":"patent is bilnd from any cause score 3. Double simultaneous stimulaton is","text_display":" patent is bilnd from any cause score 3. Double simultaneous stimulaton is","confidence":0.42370186344703353,"confidence_rate":0.9890510827978091},{"cnt":[[516,683],[1196,682],[1196,705],[516,707]],"region":{"top_left_x":516,"top_left_y":682,"width":680,"height":25},"line":23,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e387e2e7ab704bf5a3e4ca5f0f34b5e3","type":"text","conversion_output":false,"parent_id":"def8d952acec4f66a3df783cf13d9209","text":"performed at this point. If there is extinction patient recelves a 1 and the results are","text_display":" performed at this point. If there is extinction patient recelves a 1 and the results are","confidence":0.7199187405444151,"confidence_rate":0.9965827590443745},{"cnt":[[518,704],[1106,704],[1106,727],[518,727]],"region":{"top_left_x":517,"top_left_y":703,"width":589,"height":25},"line":24,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4d8fe080530e4df8b5066a34c6a3f13b","type":"text","conversion_output":false,"parent_id":"def8d952acec4f66a3df783cf13d9209","text":"used to answer question 22. Score as examined, using bilateral threat.","text_display":" used to answer question 22. Score as examined, using bilateral threat.","confidence":0.93712083223636,"confidence_rate":0.9991344674753888},{"cnt":[[1208,510],[1790,510],[1790,694],[1208,694]],"region":{"top_left_x":1207,"top_left_y":510,"width":584,"height":185},"line":25,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"163743b92d7848f293ca240787d90543","type":"complex_cell","conversion_output":false,"parent_id":"82f903c43133435cb39f77294be11554","children_ids":["51c616bc9e2e49d1826a3619a8874012","c88ba975b7ae422a8c157834e4b4651f","1d8cfd123a274905acb8638f5d6ca814","a99d88f978fa4d7e9549f864db04af28","cba3b6c24c3d41038a88de70de01c452","99f9cc7f0bee4726be1e3695f0009a4a","2adaf049983c481f8cd62608981bbab4","7a15aa8db5984e01947b0e3c0624e0c7"],"text":"◯ 0=No visual loss\n◯ \\(1=\\) Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral hemianopia (blind including cortical blindness)","text_display":"◯ 0=No visual loss\n◯ \\(1=\\) Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral 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or use pantomine to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responsive or non-comprehending patent. If facial traumalbandages, orotracheal tuipe, tape or other physical bamier obscures the face, these should be removed to the extent possible. Coma Score \"3\".","text_display":"Ask, or use pantomine to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responsive or non-comprehending patent. If facial traumalbandages, orotracheal tuipe, tape or other physical bamier obscures the face, these should be removed to the extent possible. Coma Score \"3\".","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.19711769925966477,"confidence_rate":0.9900723098031803},{"cnt":[[516,898],[1176,898],[1176,921],[516,921]],"region":{"top_left_x":516,"top_left_y":897,"width":661,"height":24},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0b6b8ff14549436799d6d96ecbd81d19","type":"text","conversion_output":false,"parent_id":"c7ed1b21b1a3469da32d37a9bba153d9","text":"Ask, or use pantomine to encourage the patient to show teeth or raise eyebrows","text_display":"Ask, or use pantomine to encourage the patient to show teeth or raise eyebrows","confidence":0.752296638835126,"confidence_rate":0.9965766613891357},{"cnt":[[518,920],[1174,920],[1174,943],[518,943]],"region":{"top_left_x":517,"top_left_y":919,"width":657,"height":24},"line":37,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4e2243823e404973a267f81dfe3d8fe9","type":"text","conversion_output":false,"parent_id":"c7ed1b21b1a3469da32d37a9bba153d9","text":"and close eyes. Score symmetry of grimace in response to noxlous stimull in the","text_display":" and close eyes. Score symmetry of grimace in response to noxlous stimull in the","confidence":0.9657396690386975,"confidence_rate":0.9995850745001859},{"cnt":[[516,939],[1136,939],[1136,965],[516,965]],"region":{"top_left_x":516,"top_left_y":938,"width":620,"height":27},"line":38,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b7ab5a500f5e48aebc5647b098b4cd45","type":"text","conversion_output":false,"parent_id":"c7ed1b21b1a3469da32d37a9bba153d9","text":"poorly responsive or non-comprehending patent. If facial traumalbandages,","text_display":" poorly responsive or non-comprehending patent. If facial traumalbandages,","confidence":0.32664980296380697,"confidence_rate":0.9857579475100412},{"cnt":[[516,963],[1187,963],[1187,986],[516,986]],"region":{"top_left_x":516,"top_left_y":963,"width":672,"height":24},"line":39,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"215764adbd73478998eab8f8d99e7238","type":"text","conversion_output":false,"parent_id":"c7ed1b21b1a3469da32d37a9bba153d9","text":"orotracheal tuipe, tape or other physical bamier obscures the face, these should be","text_display":" orotracheal tuipe, tape or other physical bamier obscures the face, these should be","confidence":0.19711769925966477,"confidence_rate":0.9817152071246966},{"cnt":[[516,982],[923,982],[923,1008],[516,1008]],"region":{"top_left_x":516,"top_left_y":982,"width":407,"height":27},"line":40,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ca4a4b71cf9f47fbbed643f1619f3878","type":"text","conversion_output":false,"parent_id":"c7ed1b21b1a3469da32d37a9bba153d9","text":"removed to the extent possible. Coma Score \"3\".","text_display":" removed to the extent possible. Coma Score \"3\".","confidence":0.5022398266948807,"confidence_rate":0.9868435145515155},{"cnt":[[1208,805],[1820,805],[1820,1034],[1208,1034]],"region":{"top_left_x":1207,"top_left_y":804,"width":614,"height":231},"line":41,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"593e66f7972142b0b8a9b001e5f03362","type":"complex_cell","conversion_output":false,"parent_id":"82f903c43133435cb39f77294be11554","children_ids":["a66bad2db2cf4394b7d8ee8a193a11c8","623013a3e06b4334aacb1a06fb982d7b","1687bb183e314cdc96f60334d36a2ab0","14e2f942bc324b1390fd8cf8f603112f","d29fdef6358a401d9201621daa459028","56bb142070fa46888c4a8551f6c4e3b5","4297a66242e341efb10764054b3771c8","4c819083bebf4d69b5f58b33668fea94","8af66bfb410245d8b215a31ce7553dde","42e416c36d94418186e5b27ad9ca4990"],"text":"◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face)","text_display":"◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face)","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.9460657860618085,"confidence_rate":0.9995541672638273},{"cnt":[[1211,808],[1245,808],[1245,842],[1211,842]],"region":{"top_left_x":1210,"top_left_y":807,"width":35,"height":35},"line":42,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a66bad2db2cf4394b7d8ee8a193a11c8","type":"form_field","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1246,816],[1567,816],[1567,845],[1246,845]],"region":{"top_left_x":1246,"top_left_y":815,"width":321,"height":30},"line":43,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"623013a3e06b4334aacb1a06fb982d7b","type":"text","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"0=Normal symmetrical movement","text_display":" 0=Normal symmetrical movement","confidence":0.9460657860618085,"confidence_rate":0.9983706473370132},{"cnt":[[1211,851],[1245,851],[1245,888],[1211,888]],"region":{"top_left_x":1210,"top_left_y":851,"width":35,"height":38},"line":44,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1687bb183e314cdc96f60334d36a2ab0","type":"form_field","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1249,862],[1789,862],[1789,891],[1249,891]],"region":{"top_left_x":1248,"top_left_y":862,"width":541,"height":29},"line":45,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"14e2f942bc324b1390fd8cf8f603112f","type":"text","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"\\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of","text_display":" \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of","confidence":0.9464151370339096,"confidence_rate":0.9991261919592026},{"cnt":[[1279,890],[1359,890],[1359,921],[1279,921]],"region":{"top_left_x":1278,"top_left_y":889,"width":82,"height":32},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d29fdef6358a401d9201621daa459028","type":"text","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"smiling)","text_display":" smiling)","confidence":0.99951171875,"confidence_rate":0.9999624314366309},{"cnt":[[1211,921],[1245,921],[1245,956],[1211,956]],"region":{"top_left_x":1210,"top_left_y":920,"width":35,"height":37},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"56bb142070fa46888c4a8551f6c4e3b5","type":"form_field","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1245,930],[1815,930],[1815,959],[1245,959]],"region":{"top_left_x":1244,"top_left_y":930,"width":571,"height":30},"line":48,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4297a66242e341efb10764054b3771c8","type":"text","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"2=Partial paralysis (total or near total paralysis of lower face)","text_display":" 2=Partial paralysis (total or near total paralysis of lower face)","confidence":0.99072265625,"confidence_rate":0.9998668567738663},{"cnt":[[1211,966],[1245,966],[1245,1003],[1211,1003]],"region":{"top_left_x":1210,"top_left_y":965,"width":35,"height":38},"line":49,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4c819083bebf4d69b5f58b33668fea94","type":"form_field","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1246,977],[1815,977],[1815,1005],[1246,1005]],"region":{"top_left_x":1246,"top_left_y":976,"width":569,"height":30},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8af66bfb410245d8b215a31ce7553dde","type":"text","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"3=Complete paralysis of one or both sides (absence of facial","text_display":" 3=Complete paralysis of one or both sides (absence of facial","confidence":1,"confidence_rate":1},{"cnt":[[1268,1004],[1638,1004],[1638,1030],[1268,1030]],"region":{"top_left_x":1267,"top_left_y":1004,"width":371,"height":27},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"42e416c36d94418186e5b27ad9ca4990","type":"text","conversion_output":false,"parent_id":"593e66f7972142b0b8a9b001e5f03362","text":"movement in the upper and lower face)","text_display":" movement in the upper and lower face)","confidence":1,"confidence_rate":1},{"cnt":[[466,1261],[485,1261],[485,1285],[466,1285]],"region":{"top_left_x":465,"top_left_y":1260,"width":20,"height":26},"line":52,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2cd1ee0612e34bed85ea7d052e68e531","type":"simple_cell","conversion_output":false,"parent_id":"82f903c43133435cb39f77294be11554","text":"8","text_display":"8","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[520,1160],[1196,1160],[1196,1382],[520,1382]],"region":{"top_left_x":520,"top_left_y":1159,"width":676,"height":223},"line":53,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"daa2e4cf4ff24aa5a7c5882018486dd5","type":"complex_cell","conversion_output":false,"parent_id":"82f903c43133435cb39f77294be11554","children_ids":["318e841b043c4c8bb54d516d25a3a487","5960512e13b742f3a11619101e12cadb","b26fb64d45294aa4be02c906f5a6441e","245ef3be6bf44c60800a6ee175d51e2c","15b719b6c8d14b2a8fd30550a6117f04","f7f6cd0c0c064cb3bcc0fefcf00298f0","75e66a4068ed4c03bc34b74ee70c8bf0","e3d402e128154959b4bd827caff50d7b","a71391faab9b488492995b6b8cbcc9dd"],"text":"\\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fuston at the shouder or hip can the examiner indicate no score and an explanation must be provided. \\\\\nComa Score \"4\"\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fuston at the shouder or hip can the examiner indicate no score and an explanation must be provided. \\\\\nComa Score \"4\"\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.19485226429328495,"confidence_rate":0.9913768401686179},{"cnt":[[760,1162],[958,1162],[958,1191],[760,1191]],"region":{"top_left_x":760,"top_left_y":1162,"width":199,"height":30},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"318e841b043c4c8bb54d516d25a3a487","type":"text","conversion_output":false,"parent_id":"daa2e4cf4ff24aa5a7c5882018486dd5","text":"(5a) Motor Arm Left","text_display":"(5a) Motor Arm Left","confidence":0.9990234375,"confidence_rate":0.999959290843314},{"cnt":[[531,1211],[1183,1211],[1183,1235],[531,1235]],"region":{"top_left_x":531,"top_left_y":1211,"width":653,"height":24},"line":55,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5960512e13b742f3a11619101e12cadb","type":"text","conversion_output":false,"parent_id":"daa2e4cf4ff24aa5a7c5882018486dd5","text":"The limb is placed in the appropriate position: extend the arms (paims down) 90","text_display":"\nThe limb is placed in the appropriate position: extend the arms (paims down) 90","confidence":0.5421622670569398,"confidence_rate":0.9926513519603878},{"cnt":[[522,1233],[1193,1233],[1193,1256],[522,1256]],"region":{"top_left_x":521,"top_left_y":1233,"width":672,"height":24},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b26fb64d45294aa4be02c906f5a6441e","type":"text","conversion_output":false,"parent_id":"daa2e4cf4ff24aa5a7c5882018486dd5","text":"degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested","text_display":" degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested","confidence":0.9432468716943742,"confidence_rate":0.9993851655444106},{"cnt":[[548,1252],[1168,1252],[1168,1276],[548,1276]],"region":{"top_left_x":547,"top_left_y":1252,"width":622,"height":24},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"245ef3be6bf44c60800a6ee175d51e2c","type":"text","conversion_output":false,"parent_id":"daa2e4cf4ff24aa5a7c5882018486dd5","text":"supine). Drift is scored if the arm falls before 10 seconds or the leg before 5","text_display":" supine). Drift is scored if the arm falls before 10 seconds or the leg before 5","confidence":0.9724308958267229,"confidence_rate":0.9996749799898679},{"cnt":[[546,1274],[1170,1274],[1170,1297],[546,1297]],"region":{"top_left_x":546,"top_left_y":1274,"width":624,"height":24},"line":58,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"15b719b6c8d14b2a8fd30550a6117f04","type":"text","conversion_output":false,"parent_id":"daa2e4cf4ff24aa5a7c5882018486dd5","text":"seconds. The aphasic patient is encouraged using urgency in the volce and","text_display":" seconds. The aphasic patient is encouraged using urgency in the volce and","confidence":0.6012403964996338,"confidence_rate":0.9934986561647005},{"cnt":[[522,1293],[1193,1293],[1193,1318],[522,1318]],"region":{"top_left_x":521,"top_left_y":1293,"width":672,"height":25},"line":59,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f7f6cd0c0c064cb3bcc0fefcf00298f0","type":"text","conversion_output":false,"parent_id":"daa2e4cf4ff24aa5a7c5882018486dd5","text":"pantomime but not noxious stimulation. Each imb is tested in tum, beginning with","text_display":" pantomime but not noxious stimulation. Each imb is tested in tum, beginning with","confidence":0.19485226429328495,"confidence_rate":0.9809425961431887},{"cnt":[[523,1318],[1193,1318],[1193,1341],[523,1341]],"region":{"top_left_x":523,"top_left_y":1317,"width":670,"height":25},"line":60,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"75e66a4068ed4c03bc34b74ee70c8bf0","type":"text","conversion_output":false,"parent_id":"daa2e4cf4ff24aa5a7c5882018486dd5","text":"the non-paretic arm. Only in cases of amputation or joint fuston at the shouder or","text_display":" the non-paretic arm. Only in cases of amputation or joint fuston at the shouder or","confidence":0.6798128717509492,"confidence_rate":0.995573759204836},{"cnt":[[539,1338],[1174,1338],[1174,1363],[539,1363]],"region":{"top_left_x":539,"top_left_y":1338,"width":635,"height":25},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e3d402e128154959b4bd827caff50d7b","type":"text","conversion_output":false,"parent_id":"daa2e4cf4ff24aa5a7c5882018486dd5","text":"hip can the examiner indicate no score and an explanation must be provided.","text_display":" hip can the examiner indicate no score and an explanation must be provided.","confidence":1,"confidence_rate":1},{"cnt":[[788,1359],[928,1359],[928,1379],[788,1379]],"region":{"top_left_x":787,"top_left_y":1358,"width":142,"height":22},"line":62,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a71391faab9b488492995b6b8cbcc9dd","type":"text","conversion_output":false,"parent_id":"daa2e4cf4ff24aa5a7c5882018486dd5","text":"Coma Score \"4\"","text_display":"\nComa Score \"4\"","confidence":0.4731323363797319,"confidence_rate":0.9613772099406298},{"cnt":[[1208,1116],[1816,1116],[1816,1434],[1208,1434]],"region":{"top_left_x":1207,"top_left_y":1115,"width":610,"height":319},"line":63,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"12c63b0c9c4048a3b15e30353b0cf5b0","type":"complex_cell","conversion_output":false,"parent_id":"82f903c43133435cb39f77294be11554","children_ids":["4d07b23b6597468caa61a4a75b544acb","1e88b4fa0b704e54a2a6582407abe317","9bdbe93e2bbe4caca65ed42972c3f3af","f40b2663bd7d4729a74188df997f3b55","811d660194574ea3b18f5251d68c1b1f","cf330967b57a47848bd22f9ad1112c32","dee621c08d4b4987b3f0ae2e8266d50e","7ba06a05056e4afe859f1a250946d21d","4ad853e66daf4ffe9fd83f777db89749","d378f0a53b244b2f9efcd962af5474b2","3bd90882dc36423ab1b6a657143ab1d8","ce86b222f0c04535a9ea6a5fa652ea00","903017a656274d66b0368577bd53ea56","b81f07c612824fd6ad2c4a1be03e0e2a"],"text":"◯ \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion","text_display":"◯ \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (if cued) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.4790496826171875,"confidence_rate":0.9937888224371518},{"cnt":[[1211,1117],[1245,1117],[1245,1153],[1211,1153]],"region":{"top_left_x":1210,"top_left_y":1117,"width":35,"height":36},"line":64,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4d07b23b6597468caa61a4a75b544acb","type":"form_field","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1246,1128],[1805,1128],[1805,1156],[1246,1156]],"region":{"top_left_x":1246,"top_left_y":1128,"width":560,"height":28},"line":65,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1e88b4fa0b704e54a2a6582407abe317","type":"text","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"\\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds","text_display":" \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds","confidence":0.6208447927016891,"confidence_rate":0.9934013926196823},{"cnt":[[1211,1162],[1245,1162],[1245,1196],[1211,1196]],"region":{"top_left_x":1210,"top_left_y":1162,"width":35,"height":35},"line":66,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9bdbe93e2bbe4caca65ed42972c3f3af","type":"form_field","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1249,1175],[1812,1175],[1812,1202],[1249,1202]],"region":{"top_left_x":1248,"top_left_y":1174,"width":565,"height":28},"line":67,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f40b2663bd7d4729a74188df997f3b55","type":"text","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"\\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before","text_display":" \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before","confidence":0.9191534163846882,"confidence_rate":0.998796407297062},{"cnt":[[1254,1201],[1563,1201],[1563,1226],[1254,1226]],"region":{"top_left_x":1254,"top_left_y":1200,"width":309,"height":27},"line":68,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"811d660194574ea3b18f5251d68c1b1f","type":"text","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"full 10 seconds; does not hit bed","text_display":" full 10 seconds; does not hit bed","confidence":1,"confidence_rate":1},{"cnt":[[1211,1233],[1245,1233],[1245,1267],[1211,1267]],"region":{"top_left_x":1210,"top_left_y":1233,"width":35,"height":35},"line":69,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cf330967b57a47848bd22f9ad1112c32","type":"form_field","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1246,1243],[1812,1243],[1812,1270],[1246,1270]],"region":{"top_left_x":1246,"top_left_y":1242,"width":567,"height":29},"line":70,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"dee621c08d4b4987b3f0ae2e8266d50e","type":"text","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"2=Some effort against gravity, limb cannot get to or maintain","text_display":" 2=Some effort against gravity, limb cannot get to or maintain","confidence":1,"confidence_rate":1},{"cnt":[[1257,1271],[1449,1271],[1449,1299],[1257,1299]],"region":{"top_left_x":1256,"top_left_y":1271,"width":194,"height":28},"line":71,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7ba06a05056e4afe859f1a250946d21d","type":"text","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"(if cued) 90 degrees","text_display":" (if cued) 90 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fails","confidence":0.9975600242614746,"confidence_rate":0.9999444797837969},{"cnt":[[1211,1347],[1245,1347],[1245,1382],[1211,1382]],"region":{"top_left_x":1210,"top_left_y":1346,"width":35,"height":36},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3bd90882dc36423ab1b6a657143ab1d8","type":"form_field","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1246,1359],[1408,1359],[1408,1382],[1246,1382]],"region":{"top_left_x":1246,"top_left_y":1358,"width":163,"height":24},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ce86b222f0c04535a9ea6a5fa652ea00","type":"text","conversion_output":false,"parent_id":"12c63b0c9c4048a3b15e30353b0cf5b0","text":"4=No movement","text_display":" 4=No 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Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm tals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomine but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fuslon at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm tals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomine but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fuslon at the shoulder or hip can the examiner indicate no score and an explanation must be provided. 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Drift is scored if the arm tals before 10 seconds or the leg before 5","text_display":" supine). Drift is scored if the arm tals before 10 seconds or the leg before 5","confidence":0.3604307900145465,"confidence_rate":0.9880664200200018},{"cnt":[[545,1757],[1171,1757],[1171,1780],[545,1780]],"region":{"top_left_x":544,"top_left_y":1757,"width":628,"height":24},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c36a7cde16b3407d861e8c85a5c74675","type":"text","conversion_output":false,"parent_id":"75061287761e41709710a129a7cc262f","text":"seconds. The aphasic patient is encouraged using urgency in the volce and","text_display":" seconds. The aphasic patient is encouraged using urgency in the volce and","confidence":0.9619140625,"confidence_rate":0.9995023012722575},{"cnt":[[522,1801],[522,1775],[1193,1777],[1193,1802]],"region":{"top_left_x":521,"top_left_y":1775,"width":672,"height":28},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"92bbf8158c7e4cc1ac853e3056f0751a","type":"text","conversion_output":false,"parent_id":"75061287761e41709710a129a7cc262f","text":"pantomine but not noxious stimulation. Each imb is tested in turn, beginning with","text_display":" pantomine but not noxious stimulation. Each imb is tested in turn, beginning with","confidence":0.22681063875475735,"confidence_rate":0.9828963316535542},{"cnt":[[522,1798],[1194,1798],[1194,1821],[522,1821]],"region":{"top_left_x":521,"top_left_y":1798,"width":674,"height":24},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3ae062856f4b407f8a506a4fcd6d5df6","type":"text","conversion_output":false,"parent_id":"75061287761e41709710a129a7cc262f","text":"the non-paretic arm. Only in cases of amputation or joint fuslon at the shoulder or","text_display":" the non-paretic arm. Only in cases of amputation or joint fuslon at the shoulder or","confidence":0.6417516427321648,"confidence_rate":0.9949722962050304},{"cnt":[[539,1819],[1174,1819],[1174,1843],[539,1843]],"region":{"top_left_x":539,"top_left_y":1818,"width":635,"height":26},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2853aa98bf6e42babd02cea91be18db8","type":"text","conversion_output":false,"parent_id":"75061287761e41709710a129a7cc262f","text":"hip can the examiner indicate no score and an explanation must be provided.","text_display":" hip can the examiner indicate no score and an explanation must be 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2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1766,2458],[1818,2458],[1818,2505],[1766,2505]],"region":{"top_left_x":1766,"top_left_y":2457,"width":52,"height":49},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe62cf2efca94ddea2dd846156f62464","type":"page_info","conversion_output":false,"text":"88","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":42},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7aa50e099924cd0ac44e3723128fad5","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.994151822293361,"confidence_rate":0.99990976799018},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a0300acbb3f462789c6b5e40d9aec4c","type":"page_info","conversion_output":false,"text":"520/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-185","page":185,"lines":[{"cnt":[[589,331],[1652,331],[1652,438],[589,438]],"region":{"top_left_x":588,"top_left_y":330,"width":1065,"height":109},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb5cd540ba554a13b7ff33ee05f07b9a","type":"section_header","conversion_output":false,"children_ids":["1e1594da62d2476a9c79b2f1e03e6ad8","269b6863ff6d4b6a85263326e21476da"],"text":"","text_display":""},{"cnt":[[920,335],[1317,335],[1317,385],[920,385]],"region":{"top_left_x":919,"top_left_y":335,"width":398,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e1594da62d2476a9c79b2f1e03e6ad8","type":"text","conversion_output":true,"parent_id":"eb5cd540ba554a13b7ff33ee05f07b9a","text":"Appendix 7 (cont.)","text_display":"\n\n\\section*{Appendix 7 (cont.)","confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[593,378],[1646,378],[1646,432],[593,432]],"region":{"top_left_x":592,"top_left_y":378,"width":1054,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"269b6863ff6d4b6a85263326e21476da","type":"text","conversion_output":true,"parent_id":"eb5cd540ba554a13b7ff33ee05f07b9a","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":" National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.9640112794004381,"confidence_rate":0.99933381683829},{"cnt":[[436,483],[1835,483],[1835,2041],[436,2041]],"region":{"top_left_x":436,"top_left_y":483,"width":1399,"height":1559},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"88fd2dc4b9dd4b619d7468f6112fbfa1","type":"table","conversion_output":true,"children_ids":["af1293f3da454b31b2a0e58348f11265","18bd8ca43b894c99a8dd500a9f5cc3cb","8186c0020cee4666b373920c7b9cf0ea","abf1cdfe57584c9b9083435d632e882c","55f8f10a6ee548a984f7508cae1bd21f","54721f232df741c4b1de13b672177a60","45e61426631e4ba3b769cdea7d919c8f","3998a6276a0b4c5fb26e5ce04b45fc68","6bfea298c6274badaa3bf09873a02b8a","57dd74fba2b54c508da81ff0ed3b5f0e","c1050e518b7b4c2db2a62c1cc4df12ab","c37513265cbe4566bf13997def4c67a7","c3e411ce82ec4296a64a472f8fc64fa5","1c2b8ab3e0644dcb97b4b36b1c21f4f2","e721ebec2c074cb59bd06f82ed85cdc2","abd190c28f2b49f6b6b5210120e9de5f","f78f74bfcef046b5ae6aeba9f003fc91","6cde014cbd4e42bb990c5a5261e6dedc","eb9ba1ccd7f943e3b9b680dc6d640b2c","49aabc5787674b7b97f1b0e81edaa419","b83e98a7c8554c1c9ebca7ed9a5e8f1a","d85e3b3e63a24f91a74cce17132299cd","e91d487dd9104346800ade78857e39c3","d19eb3eaa7ea4d7289bbada617faaa3a"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline 12 & \\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe limb is placed in the appropriate postion: extend the arms (palms down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dont Is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement.\n◯ Amputation, joint fusion \\\\\n\\hline 13 & Explain if amputation/ joint fusion (Motor Leg Left): & \\\\\n\\hline 14 & \\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dritt is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic anm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg fails to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement.\n◯ Amputation, joint fusion \\\\\n\\hline 15 & Explain if amputation/ joint fusion (Motor Leg Right): & \\\\\n\\hline 16 & \\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes open. In case of visual defect, insure testing is done in intact visual fleld. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxia is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation or joint fusion, the examiner should record the score as untestable (UN), and clearly write the explanation for this cholce. In case of bilndness, test by having the patient touch nose from extended arm postition. Coma score \" 0 \".\n\\end{tabular} & ◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion \\\\\n\\hline 17 & Explain if amputation or joint fusion (Limb Ataxia): & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 12 & \\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe limb is placed in the appropriate postion: extend the arms (palms down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dont Is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement.\n◯ Amputation, joint fusion \\\\\n\\hline 13 & Explain if amputation/ joint fusion (Motor Leg Left): & \\\\\n\\hline 14 & \\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dritt is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic anm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg fails to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement.\n◯ Amputation, joint fusion \\\\\n\\hline 15 & Explain if amputation/ joint fusion (Motor Leg Right): & \\\\\n\\hline 16 & \\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes open. In case of visual defect, insure testing is done in intact visual fleld. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxia is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation or joint fusion, the examiner should record the score as untestable (UN), and clearly write the explanation for this cholce. In case of bilndness, test by having the patient touch nose from extended arm postition. Coma score \" 0 \".\n\\end{tabular} & ◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion \\\\\n\\hline 17 & Explain if amputation or joint fusion (Limb Ataxia): & \\\\\n\\hline\n\\end{tabular}","confidence":0.10674825732638576,"confidence_rate":0.9977431753524585},{"cnt":[[459,2040],[461,486],[497,486],[495,2040]],"region":{"top_left_x":458,"top_left_y":485,"width":40,"height":1555},"line":5,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"af1293f3da454b31b2a0e58348f11265","type":"table_column","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"","text_display":""},{"cnt":[[515,484],[1098,484],[1098,2038],[515,2038]],"region":{"top_left_x":515,"top_left_y":484,"width":583,"height":1555},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"18bd8ca43b894c99a8dd500a9f5cc3cb","type":"table_column","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"","text_display":""},{"cnt":[[1103,483],[1806,483],[1806,2040],[1103,2040]],"region":{"top_left_x":1103,"top_left_y":483,"width":703,"height":1557},"line":7,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8186c0020cee4666b373920c7b9cf0ea","type":"table_column","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"","text_display":""},{"cnt":[[437,553],[1836,552],[1836,846],[437,847]],"region":{"top_left_x":437,"top_left_y":551,"width":1399,"height":297},"line":8,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"abf1cdfe57584c9b9083435d632e882c","type":"table_row","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"","text_display":""},{"cnt":[[436,930],[1834,930],[1834,962],[436,962]],"region":{"top_left_x":436,"top_left_y":930,"width":1399,"height":32},"line":9,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"55f8f10a6ee548a984f7508cae1bd21f","type":"table_row","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"","text_display":""},{"cnt":[[436,1055],[1836,1055],[1836,1349],[436,1349]],"region":{"top_left_x":436,"top_left_y":1054,"width":1400,"height":296},"line":10,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"54721f232df741c4b1de13b672177a60","type":"table_row","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"","text_display":""},{"cnt":[[436,1447],[1834,1447],[1834,1482],[436,1482]],"region":{"top_left_x":436,"top_left_y":1447,"width":1399,"height":35},"line":11,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"45e61426631e4ba3b769cdea7d919c8f","type":"table_row","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"","text_display":""},{"cnt":[[436,1585],[1836,1585],[1836,1854],[436,1854]],"region":{"top_left_x":436,"top_left_y":1585,"width":1400,"height":269},"line":12,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3998a6276a0b4c5fb26e5ce04b45fc68","type":"table_row","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"","text_display":""},{"cnt":[[436,1956],[1834,1956],[1834,1992],[436,1992]],"region":{"top_left_x":436,"top_left_y":1956,"width":1399,"height":36},"line":13,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6bfea298c6274badaa3bf09873a02b8a","type":"table_row","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"","text_display":""},{"cnt":[[458,681],[493,681],[493,707],[458,707]],"region":{"top_left_x":457,"top_left_y":680,"width":37,"height":27},"line":14,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"57dd74fba2b54c508da81ff0ed3b5f0e","type":"simple_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"12","text_display":"12","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[518,573],[1096,573],[1096,819],[518,819]],"region":{"top_left_x":517,"top_left_y":573,"width":580,"height":246},"line":15,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c1050e518b7b4c2db2a62c1cc4df12ab","type":"complex_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","children_ids":["5e59dbe6117a4b33b370c44633fea287","7ec30dad044e4439af8b9054ddd03049","4f79573858db42738a23ab5a5a5e2b08","db33648aad8e44138c5cf3fe24df8617","68f70e04abf445f0a539cf02688c79ab","eb811f0640fd4eca8bf73feb660a3591","86be29dcc1834f1dbde9be933ee6cb50","69ef0addb62a487c903fb56d379f398e","ce64fb2587db4e839f2a4ef2e0e52e97","f77ec17868dc42529680ce80fa95daa2"],"text":"\\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe limb is placed in the appropriate postion: extend the arms (palms down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dont Is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe limb is placed in the appropriate postion: extend the arms (palms down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dont Is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.10674825732638576,"confidence_rate":0.9907608304853376},{"cnt":[[712,576],[903,576],[903,604],[712,604]],"region":{"top_left_x":711,"top_left_y":575,"width":192,"height":30},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5e59dbe6117a4b33b370c44633fea287","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"(6a) Motor Leg Left","text_display":"(6a) Motor Leg Left","confidence":1,"confidence_rate":1},{"cnt":[[521,622],[1092,622],[1092,648],[521,648]],"region":{"top_left_x":520,"top_left_y":622,"width":573,"height":27},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7ec30dad044e4439af8b9054ddd03049","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"The limb is placed in the appropriate postion: extend the arms (palms","text_display":"\nThe limb is placed in the appropriate postion: extend the arms (palms","confidence":0.5726337425478525,"confidence_rate":0.9924944038680901},{"cnt":[[529,647],[1085,647],[1085,670],[529,670]],"region":{"top_left_x":528,"top_left_y":646,"width":558,"height":24},"line":18,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4f79573858db42738a23ab5a5a5e2b08","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30","text_display":" down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30","confidence":0.34138377250411184,"confidence_rate":0.9866554881002007},{"cnt":[[526,666],[1087,666],[1087,689],[526,689]],"region":{"top_left_x":526,"top_left_y":665,"width":561,"height":24},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"db33648aad8e44138c5cf3fe24df8617","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"degrees (always tested suplne). Dont Is scored if the arm fals before","text_display":" degrees (always tested suplne). Dont Is scored if the arm fals before","confidence":0.10674825732638576,"confidence_rate":0.9702189222683193},{"cnt":[[549,688],[1066,688],[1066,711],[549,711]],"region":{"top_left_x":549,"top_left_y":687,"width":518,"height":24},"line":20,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"68f70e04abf445f0a539cf02688c79ab","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"10 seconds or the leg before 5 seconds. The aphasic pattent is","text_display":" 10 seconds or the leg before 5 seconds. The aphasic pattent is","confidence":0.9583994195238006,"confidence_rate":0.9993843829425473},{"cnt":[[551,709],[1062,709],[1062,733],[551,733]],"region":{"top_left_x":550,"top_left_y":709,"width":513,"height":24},"line":21,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"eb811f0640fd4eca8bf73feb660a3591","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"encouraged using urgency in the volce and pantomime but not","text_display":" encouraged using urgency in the volce and pantomime but not","confidence":0.9621546065437647,"confidence_rate":0.999397367162926},{"cnt":[[534,731],[1079,731],[1079,754],[534,754]],"region":{"top_left_x":534,"top_left_y":731,"width":545,"height":24},"line":22,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"86be29dcc1834f1dbde9be933ee6cb50","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"noxious stimulation. Each imb is tested in turn, beginning with the","text_display":" noxious stimulation. Each imb is tested in turn, beginning with the","confidence":0.43197897895796844,"confidence_rate":0.9884096588942268},{"cnt":[[537,750],[1076,750],[1076,774],[537,774]],"region":{"top_left_x":536,"top_left_y":750,"width":540,"height":24},"line":23,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"69ef0addb62a487c903fb56d379f398e","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"non-paretic arm. Only in cases of amputation or joint fusion at the","text_display":" non-paretic arm. Only in cases of amputation or joint fusion at the","confidence":0.6235994310061815,"confidence_rate":0.9934624763387377},{"cnt":[[518,772],[1094,772],[1094,795],[518,795]],"region":{"top_left_x":517,"top_left_y":772,"width":577,"height":24},"line":24,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ce64fb2587db4e839f2a4ef2e0e52e97","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"shoulder or hip can the examiner indicate no score and an explanation","text_display":" shoulder or hip can the examiner indicate no score and an explanation","confidence":0.7762229785294039,"confidence_rate":0.9965826705610601},{"cnt":[[657,793],[956,790],[956,815],[657,818]],"region":{"top_left_x":656,"top_left_y":790,"width":300,"height":28},"line":25,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f77ec17868dc42529680ce80fa95daa2","type":"text","conversion_output":false,"parent_id":"c1050e518b7b4c2db2a62c1cc4df12ab","text":"must be provided. Coma score \"4\".","text_display":" must be provided. Coma score \"4\".","confidence":0.49022030639336944,"confidence_rate":0.9814143470976077},{"cnt":[[1104,554],[1804,554],[1804,845],[1104,845]],"region":{"top_left_x":1104,"top_left_y":553,"width":701,"height":292},"line":26,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c37513265cbe4566bf13997def4c67a7","type":"complex_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","children_ids":["59ade984d7d14d62baaa7342a1ff9185","ba2e8e02aa12492fb0ad62e81d37c66b","8e75370480df49f1bfbd58f6a6b3bd26","3cd627629b32484e8156fa3fa9cb3170","4debf766b90f4d7ebe9ecb1d434b508a","69bd4bdedf034fd78a290538975951e2","0486ce91943b4c1c9d681ab551d9a5b6","fc11bd88b49d433a9e48d0fe2647c928","c5d05b6389034670937fafb17a281e88","b74db0a7f56b4462bcae84ce0e3dd472","c6887106b73e4e22802f43052a6cdc10","da452da12326492f9778dd239d826648","75cb83180d5c4ebfbbd99d75e4f003a1"],"text":"◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement.\n◯ Amputation, joint fusion","text_display":"◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement.\n◯ Amputation, joint fusion","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.860450889342701,"confidence_rate":0.998274150976186},{"cnt":[[1107,554],[1143,554],[1143,589],[1107,589]],"region":{"top_left_x":1107,"top_left_y":553,"width":36,"height":37},"line":27,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"59ade984d7d14d62baaa7342a1ff9185","type":"form_field","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1143,563],[1687,563],[1687,593],[1143,593]],"region":{"top_left_x":1142,"top_left_y":563,"width":545,"height":31},"line":28,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ba2e8e02aa12492fb0ad62e81d37c66b","type":"text","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"0=No drift, leg holds 30 degrees position for full 5 seconds","text_display":" 0=No drift, leg holds 30 degrees position for full 5 seconds","confidence":0.8837413787841797,"confidence_rate":0.9982607984333445},{"cnt":[[1107,600],[1141,600],[1141,634],[1107,634]],"region":{"top_left_x":1107,"top_left_y":600,"width":35,"height":35},"line":29,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8e75370480df49f1bfbd58f6a6b3bd26","type":"form_field","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1143,611],[1799,611],[1799,639],[1143,639]],"region":{"top_left_x":1142,"top_left_y":611,"width":657,"height":28},"line":30,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3cd627629b32484e8156fa3fa9cb3170","type":"text","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"\\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed","text_display":" \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed","confidence":0.9985356330871582,"confidence_rate":0.9999819083100031},{"cnt":[[1107,644],[1141,644],[1141,677],[1107,677]],"region":{"top_left_x":1107,"top_left_y":643,"width":35,"height":34},"line":31,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4debf766b90f4d7ebe9ecb1d434b508a","type":"form_field","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1141,654],[1777,654],[1777,681],[1141,681]],"region":{"top_left_x":1141,"top_left_y":653,"width":636,"height":28},"line":32,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"69bd4bdedf034fd78a290538975951e2","type":"text","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"2=Some effort against gravity, leg falls to bed by 5 seconds, but has","text_display":" 2=Some effort against gravity, leg falls to bed by 5 seconds, but has","confidence":0.9270973205566406,"confidence_rate":0.9990174085852799},{"cnt":[[1151,682],[1403,682],[1403,709],[1151,709]],"region":{"top_left_x":1150,"top_left_y":682,"width":254,"height":28},"line":33,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0486ce91943b4c1c9d681ab551d9a5b6","type":"text","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"some effort against gravity","text_display":" some effort against gravity","confidence":1,"confidence_rate":1},{"cnt":[[1107,715],[1143,715],[1143,750],[1107,750]],"region":{"top_left_x":1107,"top_left_y":714,"width":36,"height":37},"line":34,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fc11bd88b49d433a9e48d0fe2647c928","type":"form_field","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1141,724],[1657,724],[1657,753],[1141,753]],"region":{"top_left_x":1141,"top_left_y":724,"width":516,"height":30},"line":35,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c5d05b6389034670937fafb17a281e88","type":"text","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"3=No effort against gravity; leg falls to bed immediately","text_display":" 3=No effort against gravity; leg falls to bed immediately","confidence":0.9146439924370497,"confidence_rate":0.9985619967138056},{"cnt":[[1107,757],[1141,757],[1141,793],[1107,793]],"region":{"top_left_x":1107,"top_left_y":757,"width":35,"height":36},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b74db0a7f56b4462bcae84ce0e3dd472","type":"form_field","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1141,769],[1305,769],[1305,793],[1141,793]],"region":{"top_left_x":1141,"top_left_y":769,"width":164,"height":24},"line":37,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c6887106b73e4e22802f43052a6cdc10","type":"text","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"4=No movement.","text_display":" 4=No movement.","confidence":0.860450889342701,"confidence_rate":0.9921207454981624},{"cnt":[[1107,802],[1141,802],[1141,839],[1107,839]],"region":{"top_left_x":1107,"top_left_y":802,"width":35,"height":38},"line":38,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"da452da12326492f9778dd239d826648","type":"form_field","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1141,814],[1365,814],[1365,842],[1141,842]],"region":{"top_left_x":1141,"top_left_y":814,"width":225,"height":28},"line":39,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"75cb83180d5c4ebfbbd99d75e4f003a1","type":"text","conversion_output":false,"parent_id":"c37513265cbe4566bf13997def4c67a7","text":"Amputation, joint fusion","text_display":" Amputation, joint fusion","confidence":1,"confidence_rate":1},{"cnt":[[458,933],[493,933],[493,958],[458,958]],"region":{"top_left_x":457,"top_left_y":933,"width":37,"height":25},"line":40,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c3e411ce82ec4296a64a472f8fc64fa5","type":"simple_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"13","text_display":"13","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[622,932],[1095,932],[1095,960],[622,960]],"region":{"top_left_x":621,"top_left_y":931,"width":474,"height":30},"line":41,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1c2b8ab3e0644dcb97b4b36b1c21f4f2","type":"simple_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"Explain if amputation/ joint fusion (Motor Leg Left):","text_display":"Explain if amputation/ joint fusion (Motor Leg Left):","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99609375,"confidence_rate":0.9999325212540148},{"cnt":[[458,1184],[493,1184],[493,1209],[458,1209]],"region":{"top_left_x":457,"top_left_y":1184,"width":37,"height":25},"line":42,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e721ebec2c074cb59bd06f82ed85cdc2","type":"simple_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"14","text_display":"14","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[515,1072],[1098,1072],[1098,1325],[515,1325]],"region":{"top_left_x":515,"top_left_y":1072,"width":583,"height":253},"line":43,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"abd190c28f2b49f6b6b5210120e9de5f","type":"complex_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","children_ids":["4ffb8738a3394227bf7e379c3c4f5c3d","7f4908dafd48484b9aa3f0c2e2dae98c","1337d79114e84fdb979f2e6ee63b2a36","4b774e48d4554deda6c84580140a5c32","6ee7c1ac58e642458c1d7b825bd8c297","9eedf00d723e42c4b0c944b15ebf2506","b1fe3e41278a4247a095cb9f10edcf87","5a1fdac67c0e4896ba9d1eb559fbe3cb","b504792285374f5e86122f6729c7c069","6ec605c7bb6a4fc680cfcd637352071c"],"text":"\\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dritt is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic anm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dritt is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic anm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.11345784647115481,"confidence_rate":0.9923968958752315},{"cnt":[[706,1078],[909,1078],[909,1106],[706,1106]],"region":{"top_left_x":706,"top_left_y":1077,"width":204,"height":30},"line":44,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4ffb8738a3394227bf7e379c3c4f5c3d","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"(6b) Motor Leg Right","text_display":"(6b) Motor Leg Right","confidence":1,"confidence_rate":1},{"cnt":[[518,1127],[1089,1127],[1089,1150],[518,1150]],"region":{"top_left_x":517,"top_left_y":1126,"width":573,"height":25},"line":45,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7f4908dafd48484b9aa3f0c2e2dae98c","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"The imb is placed in the appropriate position: extend the arms (paims","text_display":"\nThe imb is placed in the appropriate position: extend the arms (paims","confidence":0.9528549253445817,"confidence_rate":0.9993476099752555},{"cnt":[[518,1149],[1074,1149],[1074,1172],[518,1172]],"region":{"top_left_x":517,"top_left_y":1148,"width":558,"height":24},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1337d79114e84fdb979f2e6ee63b2a36","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30","text_display":" down) 90 degrees (if sttting) or 45 degrees (if supine) and the leg 30","confidence":0.16744501501509268,"confidence_rate":0.9779089092344359},{"cnt":[[518,1168],[1081,1168],[1081,1194],[518,1194]],"region":{"top_left_x":517,"top_left_y":1167,"width":565,"height":27},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4b774e48d4554deda6c84580140a5c32","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"degrees (always tested suplne). Dritt is scored if the arm falls before","text_display":" degrees (always tested suplne). Dritt is scored if the arm falls before","confidence":0.11345784647115481,"confidence_rate":0.9717702790385027},{"cnt":[[519,1190],[1039,1190],[1039,1213],[519,1213]],"region":{"top_left_x":519,"top_left_y":1189,"width":520,"height":24},"line":48,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6ee7c1ac58e642458c1d7b825bd8c297","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"10 seconds or the leg before 5 seconds. The aphasic patient is","text_display":" 10 seconds or the leg before 5 seconds. The aphasic patient is","confidence":0.9543152235559481,"confidence_rate":0.9993225304688342},{"cnt":[[518,1211],[1032,1211],[1032,1235],[518,1235]],"region":{"top_left_x":517,"top_left_y":1211,"width":516,"height":24},"line":49,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9eedf00d723e42c4b0c944b15ebf2506","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"encouraged using urgency in the volce and pantomime but not","text_display":" encouraged using urgency in the volce and pantomime but not","confidence":0.9980475902557373,"confidence_rate":0.9999694642446537},{"cnt":[[518,1233],[1062,1233],[1062,1256],[518,1256]],"region":{"top_left_x":517,"top_left_y":1233,"width":546,"height":24},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b1fe3e41278a4247a095cb9f10edcf87","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"noxious stimulation. Each imb is tested in turn, beginning with the","text_display":" noxious stimulation. Each imb is tested in turn, beginning with the","confidence":0.6202449888919411,"confidence_rate":0.9933880566253447},{"cnt":[[518,1252],[1059,1252],[1059,1276],[518,1276]],"region":{"top_left_x":517,"top_left_y":1252,"width":543,"height":24},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5a1fdac67c0e4896ba9d1eb559fbe3cb","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"non-paretic anm. Only in cases of amputation or joint fusion at the","text_display":" non-paretic anm. Only in cases of amputation or joint fusion at the","confidence":0.5160078358073863,"confidence_rate":0.9908527412814098},{"cnt":[[518,1274],[1095,1274],[1095,1297],[518,1297]],"region":{"top_left_x":517,"top_left_y":1274,"width":578,"height":24},"line":52,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b504792285374f5e86122f6729c7c069","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"shoulder or hip can the examiner indicate no score and an explanation","text_display":" shoulder or hip can the examiner indicate no score and an explanation","confidence":0.6278585237450898,"confidence_rate":0.9937300035937437},{"cnt":[[518,1296],[817,1294],[817,1318],[518,1320]],"region":{"top_left_x":517,"top_left_y":1294,"width":300,"height":27},"line":53,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6ec605c7bb6a4fc680cfcd637352071c","type":"text","conversion_output":false,"parent_id":"abd190c28f2b49f6b6b5210120e9de5f","text":"must be provided. Coma score \"4\".","text_display":" must be provided. Coma score \"4\".","confidence":0.9312951565269582,"confidence_rate":0.9981286211057006},{"cnt":[[1104,1056],[1799,1056],[1799,1347],[1104,1347]],"region":{"top_left_x":1104,"top_left_y":1055,"width":695,"height":292},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f78f74bfcef046b5ae6aeba9f003fc91","type":"complex_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","children_ids":["3a33493e667e483789a1229ccb6055a5","1c2a9a6069574d7d8884b21412519178","b530b89e6d844f278f74fc2a33601565","a5c883acf7cb4193a7fa4a5c1e569cfa","cfb26d94b2264e4ca2a7563fb1ea6fb1","f2e0321e72574db89d8ecd48e3d97d25","dad553e7ac614c44ae3969bcfa17fb3d","918187813af642a6948be2918766a3aa","4735509a61464eccbec00c7e26e5aeba","b0cab5725686445bb809ef1051b49fff","cef78e46dcd34e9185f0fde81232b689","5c5ca4eda6db42fe8377b54417820753","1213a4c19d76468aa64624cf1d04f7b0"],"text":"◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg fails to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement.\n◯ Amputation, joint fusion","text_display":"◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg fails to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement.\n◯ Amputation, joint fusion","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.47278792668798975,"confidence_rate":0.9949711863509665},{"cnt":[[1107,1057],[1143,1057],[1143,1093],[1107,1093]],"region":{"top_left_x":1107,"top_left_y":1057,"width":36,"height":36},"line":55,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3a33493e667e483789a1229ccb6055a5","type":"form_field","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1143,1067],[1687,1067],[1687,1096],[1143,1096]],"region":{"top_left_x":1142,"top_left_y":1066,"width":545,"height":30},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1c2a9a6069574d7d8884b21412519178","type":"text","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"\\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds","text_display":" \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds","confidence":0.47278792668798975,"confidence_rate":0.9895046428664126},{"cnt":[[1107,1102],[1141,1102],[1141,1136],[1107,1136]],"region":{"top_left_x":1107,"top_left_y":1102,"width":35,"height":35},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b530b89e6d844f278f74fc2a33601565","type":"form_field","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1143,1113],[1799,1113],[1799,1142],[1143,1142]],"region":{"top_left_x":1142,"top_left_y":1113,"width":657,"height":29},"line":58,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a5c883acf7cb4193a7fa4a5c1e569cfa","type":"text","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"\\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed","text_display":" \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed","confidence":0.9941530115938804,"confidence_rate":0.999927605719762},{"cnt":[[1107,1146],[1141,1146],[1141,1180],[1107,1180]],"region":{"top_left_x":1107,"top_left_y":1145,"width":35,"height":36},"line":59,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cfb26d94b2264e4ca2a7563fb1ea6fb1","type":"form_field","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1143,1157],[1777,1157],[1777,1184],[1143,1184]],"region":{"top_left_x":1142,"top_left_y":1156,"width":635,"height":29},"line":60,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f2e0321e72574db89d8ecd48e3d97d25","type":"text","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"2=Some effort against gravity; leg fails to bed by 5 seconds, but has","text_display":" 2=Some effort against gravity; leg fails to bed by 5 seconds, but has","confidence":0.7542773450259119,"confidence_rate":0.9963444233122145},{"cnt":[[1151,1184],[1403,1184],[1403,1213],[1151,1213]],"region":{"top_left_x":1150,"top_left_y":1184,"width":254,"height":29},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"dad553e7ac614c44ae3969bcfa17fb3d","type":"text","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"some effort against gravity","text_display":" some effort against gravity","confidence":1,"confidence_rate":1},{"cnt":[[1107,1217],[1141,1217],[1141,1251],[1107,1251]],"region":{"top_left_x":1107,"top_left_y":1216,"width":35,"height":36},"line":62,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"918187813af642a6948be2918766a3aa","type":"form_field","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1143,1228],[1657,1228],[1657,1255],[1143,1255]],"region":{"top_left_x":1142,"top_left_y":1227,"width":515,"height":29},"line":63,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4735509a61464eccbec00c7e26e5aeba","type":"text","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"3=No effort against gravity, leg falls to bed immediately","text_display":" 3=No effort against gravity, leg falls to bed immediately","confidence":0.9926843643188477,"confidence_rate":0.9998815791708244},{"cnt":[[1107,1261],[1141,1261],[1141,1295],[1107,1295]],"region":{"top_left_x":1107,"top_left_y":1260,"width":35,"height":35},"line":64,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b0cab5725686445bb809ef1051b49fff","type":"form_field","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1143,1271],[1305,1271],[1305,1295],[1143,1295]],"region":{"top_left_x":1142,"top_left_y":1271,"width":163,"height":24},"line":65,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cef78e46dcd34e9185f0fde81232b689","type":"text","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"4=No movement.","text_display":" 4=No movement.","confidence":0.6724381861276925,"confidence_rate":0.9793300303641824},{"cnt":[[1107,1304],[1141,1304],[1141,1341],[1107,1341]],"region":{"top_left_x":1107,"top_left_y":1304,"width":35,"height":38},"line":66,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5c5ca4eda6db42fe8377b54417820753","type":"form_field","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1143,1318],[1365,1318],[1365,1344],[1143,1344]],"region":{"top_left_x":1142,"top_left_y":1317,"width":224,"height":27},"line":67,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1213a4c19d76468aa64624cf1d04f7b0","type":"text","conversion_output":false,"parent_id":"f78f74bfcef046b5ae6aeba9f003fc91","text":"Amputation, joint fusion","text_display":" Amputation, joint fusion","confidence":1,"confidence_rate":1},{"cnt":[[458,1449],[493,1449],[493,1476],[458,1476]],"region":{"top_left_x":457,"top_left_y":1448,"width":37,"height":29},"line":68,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6cde014cbd4e42bb990c5a5261e6dedc","type":"simple_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"15","text_display":"15","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[608,1449],[1095,1449],[1095,1480],[608,1480]],"region":{"top_left_x":607,"top_left_y":1448,"width":488,"height":33},"line":69,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"eb9ba1ccd7f943e3b9b680dc6d640b2c","type":"simple_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"Explain if amputation/ joint fusion (Motor Leg Right):","text_display":"Explain if amputation/ joint fusion (Motor Leg Right):","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[458,1708],[493,1708],[493,1735],[458,1735]],"region":{"top_left_x":457,"top_left_y":1708,"width":37,"height":28},"line":70,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"49aabc5787674b7b97f1b0e81edaa419","type":"simple_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"16","text_display":"16","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[518,1587],[1095,1587],[1095,1854],[518,1854]],"region":{"top_left_x":517,"top_left_y":1586,"width":578,"height":268},"line":71,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","type":"complex_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","children_ids":["be47f13f63c0403d8cc1d0be474e8102","1475c32690264ba8b8ea987bae8c42d8","9715c0695bdf4da4a434c47cd84d0385","5997894985004b85a0544f3a62caa0ad","43e62a111e764aea820a3b7838ca330e","cd425fc875614228b45eb518b218507c","be575628f93e46c49480bf38b1309380","6b8b101316914c398711d96775a41a7d","dcd5f0b7fe1f43baa7bd6cc195abf2f8","abb12f929ef84a609258098cac6b1965","fba0bca4355f44c6bd719fade7ed7c54"],"text":"\\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes open. In case of visual defect, insure testing is done in intact visual fleld. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxia is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation or joint fusion, the examiner should record the score as untestable (UN), and clearly write the explanation for this cholce. In case of bilndness, test by having the patient touch nose from extended arm postition. Coma score \" 0 \".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes open. In case of visual defect, insure testing is done in intact visual fleld. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxia is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation or joint fusion, the examiner should record the score as untestable (UN), and clearly write the explanation for this cholce. In case of bilndness, test by having the patient touch nose from extended arm postition. Coma score \" 0 \".\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.2996052472528439,"confidence_rate":0.9927676527630812},{"cnt":[[731,1591],[882,1591],[882,1617],[731,1617]],"region":{"top_left_x":730,"top_left_y":1590,"width":153,"height":27},"line":72,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"be47f13f63c0403d8cc1d0be474e8102","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"(7) Limb Ataxia","text_display":"(7) Limb Ataxia","confidence":1,"confidence_rate":1},{"cnt":[[521,1637],[1092,1637],[1092,1663],[521,1663]],"region":{"top_left_x":520,"top_left_y":1637,"width":573,"height":27},"line":73,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1475c32690264ba8b8ea987bae8c42d8","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"This item is aimed at finding evidence of a unilateral cerebelar lesion.","text_display":"\nThis item is aimed at finding evidence of a unilateral cerebelar lesion.","confidence":0.7543007281944406,"confidence_rate":0.9963448244415471},{"cnt":[[519,1662],[1092,1662],[1092,1685],[519,1685]],"region":{"top_left_x":519,"top_left_y":1661,"width":574,"height":24},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9715c0695bdf4da4a434c47cd84d0385","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"Test with eyes open. In case of visual defect, insure testing is done in","text_display":" Test with eyes open. In case of visual defect, insure testing is done in","confidence":0.6011672534505124,"confidence_rate":0.993412932146698},{"cnt":[[542,1683],[1070,1683],[1070,1707],[542,1707]],"region":{"top_left_x":542,"top_left_y":1683,"width":529,"height":24},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5997894985004b85a0544f3a62caa0ad","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"intact visual fleld. The finger-nose-finger and heel-shin tests are","text_display":" intact visual fleld. The finger-nose-finger and heel-shin tests are","confidence":0.2996052472528439,"confidence_rate":0.9833992052903612},{"cnt":[[531,1703],[1081,1703],[1081,1726],[531,1726]],"region":{"top_left_x":531,"top_left_y":1702,"width":551,"height":24},"line":76,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"43e62a111e764aea820a3b7838ca330e","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"performed on both sides, and ataxia is scored only if present put of","text_display":" performed on both sides, and ataxia is scored only if present put of","confidence":0.7399026320709613,"confidence_rate":0.9958819725659213},{"cnt":[[531,1724],[1081,1724],[1081,1748],[531,1748]],"region":{"top_left_x":531,"top_left_y":1724,"width":551,"height":24},"line":77,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cd425fc875614228b45eb518b218507c","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"proportion to weakness. Ataxla is absent in the patient who cannot","text_display":" proportion to weakness. Ataxla is absent in the patient who cannot","confidence":0.9115938214273456,"confidence_rate":0.9986971767450531},{"cnt":[[534,1743],[1081,1743],[1081,1768],[534,1768]],"region":{"top_left_x":534,"top_left_y":1743,"width":548,"height":26},"line":78,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"be575628f93e46c49480bf38b1309380","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"understand or is paralyzed. Only in the case of amputation or joint","text_display":" understand or is paralyzed. Only in the case of amputation or joint","confidence":0.8919905089949225,"confidence_rate":0.9984137623708002},{"cnt":[[523,1765],[1092,1765],[1092,1790],[523,1790]],"region":{"top_left_x":523,"top_left_y":1765,"width":570,"height":25},"line":79,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6b8b101316914c398711d96775a41a7d","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"fusion, the examiner should record the score as untestable (UN), and","text_display":" fusion, the examiner should record the score as untestable (UN), and","confidence":0.9673876063898206,"confidence_rate":0.9995459109388031},{"cnt":[[523,1787],[1092,1787],[1092,1810],[523,1810]],"region":{"top_left_x":523,"top_left_y":1787,"width":570,"height":24},"line":80,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"dcd5f0b7fe1f43baa7bd6cc195abf2f8","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"clearly write the explanation for this cholce. In case of bilndness, test","text_display":" clearly write the explanation for this cholce. In case of bilndness, test","confidence":0.7266258176340095,"confidence_rate":0.995914220529053},{"cnt":[[553,1809],[1057,1809],[1057,1832],[553,1832]],"region":{"top_left_x":553,"top_left_y":1808,"width":504,"height":25},"line":81,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"abb12f929ef84a609258098cac6b1965","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"by having the patient touch nose from extended arm postition.","text_display":" by having the patient touch nose from extended arm postition.","confidence":0.4455104262930416,"confidence_rate":0.9878242075182991},{"cnt":[[736,1828],[874,1828],[874,1851],[736,1851]],"region":{"top_left_x":736,"top_left_y":1828,"width":138,"height":24},"line":82,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fba0bca4355f44c6bd719fade7ed7c54","type":"text","conversion_output":false,"parent_id":"b83e98a7c8554c1c9ebca7ed9a5e8f1a","text":"Coma score \" 0 \".","text_display":" Coma score \" 0 \".","confidence":0.48411303872937905,"confidence_rate":0.971399490144204},{"cnt":[[1104,1634],[1439,1634],[1439,1812],[1104,1812]],"region":{"top_left_x":1104,"top_left_y":1634,"width":335,"height":178},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d85e3b3e63a24f91a74cce17132299cd","type":"complex_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","children_ids":["0c92b86939a648dc84c2a4a9e452f0a4","bccfaace7ea84334a72d44b28cbe5932","42cabf7b7e5e455190415bde503f3b18","5a900331410b436f90bd2229b0ac869a","d8d0818a0d284c7a9f29360dcc0131e7","f2e140be318c428a9fab546011cd470c","4c595624dd7d441095ae70d1309301c8","3ca3013ad34e4e56ae0340f76324f895"],"text":"◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion","text_display":"◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.8499713917262852,"confidence_rate":0.9971227401617738},{"cnt":[[1107,1637],[1143,1637],[1143,1673],[1107,1673]],"region":{"top_left_x":1107,"top_left_y":1637,"width":36,"height":36},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0c92b86939a648dc84c2a4a9e452f0a4","type":"form_field","conversion_output":false,"parent_id":"d85e3b3e63a24f91a74cce17132299cd","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1143,1648],[1250,1648],[1250,1671],[1143,1671]],"region":{"top_left_x":1142,"top_left_y":1648,"width":109,"height":24},"line":85,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bccfaace7ea84334a72d44b28cbe5932","type":"text","conversion_output":false,"parent_id":"d85e3b3e63a24f91a74cce17132299cd","text":"\\(0=\\) Absent","text_display":" \\(0=\\) Absent","confidence":0.9152018430177122,"confidence_rate":0.9932069741949592},{"cnt":[[1107,1681],[1141,1681],[1141,1718],[1107,1718]],"region":{"top_left_x":1107,"top_left_y":1680,"width":35,"height":38},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"42cabf7b7e5e455190415bde503f3b18","type":"form_field","conversion_output":false,"parent_id":"d85e3b3e63a24f91a74cce17132299cd","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1143,1692],[1362,1692],[1362,1718],[1143,1718]],"region":{"top_left_x":1142,"top_left_y":1691,"width":221,"height":27},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5a900331410b436f90bd2229b0ac869a","type":"text","conversion_output":false,"parent_id":"d85e3b3e63a24f91a74cce17132299cd","text":"1 = Present in one limb","text_display":" 1 = Present in one limb","confidence":0.99853515625,"confidence_rate":0.9999457082263518},{"cnt":[[1107,1727],[1141,1727],[1141,1763],[1107,1763]],"region":{"top_left_x":1107,"top_left_y":1727,"width":35,"height":36},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d8d0818a0d284c7a9f29360dcc0131e7","type":"form_field","conversion_output":false,"parent_id":"d85e3b3e63a24f91a74cce17132299cd","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1143,1738],[1370,1738],[1370,1764],[1143,1764]],"region":{"top_left_x":1142,"top_left_y":1738,"width":229,"height":26},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f2e140be318c428a9fab546011cd470c","type":"text","conversion_output":false,"parent_id":"d85e3b3e63a24f91a74cce17132299cd","text":"2 = Present in two limbs","text_display":" 2 = Present in two limbs","confidence":0.99609375,"confidence_rate":0.9998602276504531},{"cnt":[[1107,1771],[1141,1771],[1141,1806],[1107,1806]],"region":{"top_left_x":1107,"top_left_y":1770,"width":35,"height":37},"line":90,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4c595624dd7d441095ae70d1309301c8","type":"form_field","conversion_output":false,"parent_id":"d85e3b3e63a24f91a74cce17132299cd","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1141,1783],[1436,1783],[1436,1810],[1141,1810]],"region":{"top_left_x":1141,"top_left_y":1783,"width":295,"height":28},"line":91,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3ca3013ad34e4e56ae0340f76324f895","type":"text","conversion_output":false,"parent_id":"d85e3b3e63a24f91a74cce17132299cd","text":"UN = amputation or joint fusion","text_display":" UN = amputation or joint fusion","confidence":0.8499713917262852,"confidence_rate":0.9954948292301109},{"cnt":[[458,1959],[493,1959],[493,1988],[458,1988]],"region":{"top_left_x":457,"top_left_y":1959,"width":37,"height":29},"line":92,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e91d487dd9104346800ade78857e39c3","type":"simple_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"17","text_display":"17","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[572,1959],[1040,1959],[1040,1990],[572,1990]],"region":{"top_left_x":572,"top_left_y":1959,"width":469,"height":32},"line":93,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d19eb3eaa7ea4d7289bbada617faaa3a","type":"simple_cell","conversion_output":false,"parent_id":"88fd2dc4b9dd4b619d7468f6112fbfa1","text":"Explain if amputation or joint fusion (Limb Ataxia):","text_display":"Explain if amputation or joint fusion (Limb Ataxia):","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[425,2419],[851,2419],[851,2464],[425,2464]],"region":{"top_left_x":425,"top_left_y":2419,"width":426,"height":46},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"285c625d02b9462b916383c5c21fae83","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9980475902557373,"confidence_rate":0.9999348581824669},{"cnt":[[430,2458],[849,2458],[849,2499],[430,2499]],"region":{"top_left_x":429,"top_left_y":2457,"width":420,"height":42},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"987cbda8f1b846f58bbaecd7cf5591e0","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1766,2458],[1818,2458],[1818,2505],[1766,2505]],"region":{"top_left_x":1766,"top_left_y":2457,"width":52,"height":49},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f601e95aece04e1fa16c6189e3722050","type":"page_info","conversion_output":false,"text":"89","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":42},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccd734ff3ac142f2b7263032958f9a58","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9946386743121138,"confidence_rate":0.9999172995864799},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a410a3f3b1b4966b4e3185df2d738fe","type":"page_info","conversion_output":false,"text":"521/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-186","page":186,"lines":[{"cnt":[[589,327],[1652,327],[1652,438],[589,438]],"region":{"top_left_x":588,"top_left_y":326,"width":1065,"height":113},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15e0c1b77eed4a58a91746cb733e7530","type":"section_header","conversion_output":false,"children_ids":["420a049082dc4a949831069884463ba6","5e78d54be85043ccb522aeebd13bea0c"],"text":"","text_display":""},{"cnt":[[920,333],[1317,333],[1317,385],[920,385]],"region":{"top_left_x":919,"top_left_y":333,"width":398,"height":52},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"420a049082dc4a949831069884463ba6","type":"text","conversion_output":true,"parent_id":"15e0c1b77eed4a58a91746cb733e7530","text":"Appendix 7 (cont.)","text_display":"\n\n\\section*{Appendix 7 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[593,378],[1646,378],[1646,432],[593,432]],"region":{"top_left_x":592,"top_left_y":378,"width":1054,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e78d54be85043ccb522aeebd13bea0c","type":"text","conversion_output":true,"parent_id":"15e0c1b77eed4a58a91746cb733e7530","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":" \\\\ National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.9115420994348824,"confidence_rate":0.9983174625295809},{"cnt":[[434,477],[1807,477],[1807,2007],[434,2007]],"region":{"top_left_x":433,"top_left_y":476,"width":1374,"height":1531},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"20bc3e830f374bf7a6dc08d620878819","type":"table","conversion_output":true,"children_ids":["17aa3af64b854671a1271d0ca0905ad5","36140744d47642128695bbf9a93968b1","f3c992c1fffc4b16aed16f4ed33473f0","9f6525d8163d42d39844f74eed496e55","fb58ce49899041f6ad5f4b4f3ed0b826","8c4dbfc21fb5454aa13cfa05957aa8d2","786d41fc2c98464190acb01d531d402f","7e38f8680c2841a4b65dc078bcd8a92a","ad9570df803042f9a26ff8dc3ce349f7","a9e3975818634f6b869acd665c5fe738","ec6ab9a7482649369d2c8eab2a84cef2","7fbb901b5732444db37b84e1928a7ceb","a8150b30996140dc982c5dca172d3dac","67ecb5e4a9024d30a450adb470125f71","a206a5173d384f24a04b7fe88fc33780","8cee07e0f49045dfb2410f0a31e6f578","f622ae23bcff4e3b8b47373652ce3119","1473939888724932a6a7fd5d3bf17cf5","c31a655582c14dce8a2c9e456e31ed6c","bf1ac6880537466f8cd16d5c7fd5567a","c0aefafbd9ce4cda930aa67779de0e3e","398426fc2d6547318e0cef80f588f3c5","896f118f5bd7401d95149163f27b775c","4f5146af57a94675ac76192bf8cce1a6","e1d1984acaea489bb6555654ad07df06","d6d5d99c3788428b8a0303e55fb7fa63","d2c5cdbf2a8b42da98ea0e99404aa219","2a0a6cbf62a14586be568053f8d2378d"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline 18 & \\begin{tabular}{l}\n(8) Sensory \\\\\nSensation or grimace to pin prick when tested, or withdrawal from noxdous stimusus in the obtunded or aphasic patlent. Only sensory loss attributed to stroke is scored as abonomal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, \"severe or fotal,\" should only be given when a severe or total loss of sensation can be clearly demonstrated. Stuporous and aphasic patients will therefore probably score 1 or 0 . The patient with brain stem stroke who has bilateral loss of sersation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (tem 13-3) are artitrarily given a 2 on this them. Coma Score \"2\".\n\\end{tabular} & ◯ \\(0=\\) Normal: no sensory loss\n◯ \\(1=\\) Midd to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side: or there is a loss of superficial pain with pinprick but patent is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg \\\\\n\\hline 19 & \\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of information about comprehension will be obtained during the preceding sections of the examination. The patient is asked to describe what is happening in the attached ploture, to name the thems on the attached naming sheet, and to read from the attached ilst of sentences. Comprehension is judged from responses here as well as to all of the commands in the preceding general neurciogical exam. if visual loss Interferes with the tests, ask the patent to identity objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to witte. The patlent in coma (question 13-3) will arbitrarily score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a score of 3 should be used only if the patent is mute and follows no one step commands. Coma Score '3'.\n\\end{tabular} & ◯ \\(0=\\) No aphasia normal\n◯ 1=Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2 =Severe aphasia; all communication is through fragmentary expression; great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension \\\\\n\\hline 20 & \\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be normal an adequate sample of speech must be colained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the clarty of artioulation of spontaneous speech can be rated. Only if the patient is intubated or has other physical barrier to producing speech, may the liem be not scored, and the examiner must clearly witle an explanation. Do not teil the parlent why heishe is being tested. Coma Score \"2\".\n\\end{tabular} & ◯ 0=Normal\n◯ \\(1=\\) Mild to moderate: patient slurs at least some words and at worst. can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mute/ anarthric\n◯ Intubated or other physical barrier. \\\\\n\\hline 21 & Explain if intubated or other physical barrier (Dysarthria): & \\\\\n\\hline 22 & \\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumficient information to Identiy neglect may be obtained during the proor testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the cutaneous stimull are normal, the score is normal. If the patent has aphasla but does appear to attend to both sides, the score is nomal. The presence of visual spallal neglect or anosagnosla may also be taken as evidence of abonormally. Since the abnormality is scored only if present, the item is never untestable. Coma Score \" 2 \".\n\\end{tabular} & ◯ 0=No abnomality\n◯ \\(1=\\) Visual, tactle, auditory, spatial, or personal inattention or extinction to bilateral simultaneous stimulation in one of the sensory modalities\n◯ 2=Profound hemi-inattention or hemi-inattention to more than one modality; does not recognize own hand or orients to only one side of space \\\\\n\\hline 23 & Not applicable & \\\\\n\\hline 24 & \\begin{tabular}{l}\nName of assessor: \\\\\nThe assessor must be a study team member who has completed NIHSS certification.\n\\end{tabular} & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 18 & \\begin{tabular}{l}\n(8) Sensory \\\\\nSensation or grimace to pin prick when tested, or withdrawal from noxdous stimusus in the obtunded or aphasic patlent. Only sensory loss attributed to stroke is scored as abonomal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, \"severe or fotal,\" should only be given when a severe or total loss of sensation can be clearly demonstrated. Stuporous and aphasic patients will therefore probably score 1 or 0 . The patient with brain stem stroke who has bilateral loss of sersation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (tem 13-3) are artitrarily given a 2 on this them. Coma Score \"2\".\n\\end{tabular} & ◯ \\(0=\\) Normal: no sensory loss\n◯ \\(1=\\) Midd to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side: or there is a loss of superficial pain with pinprick but patent is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg \\\\\n\\hline 19 & \\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of information about comprehension will be obtained during the preceding sections of the examination. The patient is asked to describe what is happening in the attached ploture, to name the thems on the attached naming sheet, and to read from the attached ilst of sentences. Comprehension is judged from responses here as well as to all of the commands in the preceding general neurciogical exam. if visual loss Interferes with the tests, ask the patent to identity objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to witte. The patlent in coma (question 13-3) will arbitrarily score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a score of 3 should be used only if the patent is mute and follows no one step commands. Coma Score '3'.\n\\end{tabular} & ◯ \\(0=\\) No aphasia normal\n◯ 1=Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2 =Severe aphasia; all communication is through fragmentary expression; great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension \\\\\n\\hline 20 & \\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be normal an adequate sample of speech must be colained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the clarty of artioulation of spontaneous speech can be rated. Only if the patient is intubated or has other physical barrier to producing speech, may the liem be not scored, and the examiner must clearly witle an explanation. Do not teil the parlent why heishe is being tested. Coma Score \"2\".\n\\end{tabular} & ◯ 0=Normal\n◯ \\(1=\\) Mild to moderate: patient slurs at least some words and at worst. can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mute/ anarthric\n◯ Intubated or other physical barrier. \\\\\n\\hline 21 & Explain if intubated or other physical barrier (Dysarthria): & \\\\\n\\hline 22 & \\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumficient information to Identiy neglect may be obtained during the proor testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the cutaneous stimull are normal, the score is normal. If the patent has aphasla but does appear to attend to both sides, the score is nomal. The presence of visual spallal neglect or anosagnosla may also be taken as evidence of abonormally. Since the abnormality is scored only if present, the item is never untestable. Coma Score \" 2 \".\n\\end{tabular} & ◯ 0=No abnomality\n◯ \\(1=\\) Visual, tactle, auditory, spatial, or personal inattention or extinction to bilateral simultaneous stimulation in one of the sensory modalities\n◯ 2=Profound hemi-inattention or hemi-inattention to more than one modality; does not recognize own hand or orients to only one side of space \\\\\n\\hline 23 & Not applicable & \\\\\n\\hline 24 & \\begin{tabular}{l}\nName of assessor: \\\\\nThe assessor must be a study team member who has completed NIHSS certification.\n\\end{tabular} & \\\\\n\\hline\n\\end{tabular}","confidence":0.023615889106870548,"confidence_rate":0.9970867571668317},{"cnt":[[456,2007],[458,476],[494,476],[493,2007]],"region":{"top_left_x":456,"top_left_y":475,"width":39,"height":1532},"line":5,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"17aa3af64b854671a1271d0ca0905ad5","type":"table_column","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[512,479],[1125,479],[1125,2007],[512,2007]],"region":{"top_left_x":512,"top_left_y":478,"width":613,"height":1529},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"36140744d47642128695bbf9a93968b1","type":"table_column","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[1125,2007],[1127,478],[1792,479],[1790,2007]],"region":{"top_left_x":1125,"top_left_y":477,"width":668,"height":1531},"line":7,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f3c992c1fffc4b16aed16f4ed33473f0","type":"table_column","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[433,509],[1805,507],[1805,765],[433,767]],"region":{"top_left_x":432,"top_left_y":507,"width":1374,"height":260},"line":8,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9f6525d8163d42d39844f74eed496e55","type":"table_row","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[433,783],[1805,783],[1805,1094],[433,1094]],"region":{"top_left_x":433,"top_left_y":782,"width":1373,"height":312},"line":9,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fb58ce49899041f6ad5f4b4f3ed0b826","type":"table_row","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[433,1112],[1805,1112],[1805,1359],[433,1359]],"region":{"top_left_x":433,"top_left_y":1111,"width":1373,"height":248},"line":10,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8c4dbfc21fb5454aa13cfa05957aa8d2","type":"table_row","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[433,1387],[1804,1387],[1804,1423],[433,1423]],"region":{"top_left_x":433,"top_left_y":1387,"width":1371,"height":36},"line":11,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"786d41fc2c98464190acb01d531d402f","type":"table_row","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[433,1465],[1805,1465],[1805,1694],[433,1694]],"region":{"top_left_x":433,"top_left_y":1465,"width":1373,"height":230},"line":12,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7e38f8680c2841a4b65dc078bcd8a92a","type":"table_row","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[433,1726],[1805,1725],[1805,1816],[433,1817]],"region":{"top_left_x":432,"top_left_y":1724,"width":1374,"height":94},"line":13,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ad9570df803042f9a26ff8dc3ce349f7","type":"table_row","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[436,1897],[1804,1894],[1804,1992],[436,1994]],"region":{"top_left_x":435,"top_left_y":1893,"width":1370,"height":102},"line":14,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a9e3975818634f6b869acd665c5fe738","type":"table_row","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"","text_display":""},{"cnt":[[466,619],[490,619],[490,648],[466,648]],"region":{"top_left_x":465,"top_left_y":619,"width":26,"height":29},"line":15,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ec6ab9a7482649369d2c8eab2a84cef2","type":"simple_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"18","text_display":"18","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[518,510],[1119,510],[1119,764],[518,764]],"region":{"top_left_x":517,"top_left_y":510,"width":603,"height":254},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7fbb901b5732444db37b84e1928a7ceb","type":"complex_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","children_ids":["beec94b8212d4880a13fd437c2639064","4efc2228954146c8b70f969f6dcebd97","9271ff9e6d9d439a97070e71ab0d5fc4","58e61c0e9a534071a0e54590d500194c","c18016ce287445e5a9a87675488c63c1","3a0aeed551ef4d34956f40da3028ecfa","97704b79d02e42818d7b33db8c476fa5","368cd169a9614cc4b7419431bb1b0b42","6b2b5bef30b8414fb825126e5790dbbc","d69f6df8be744c149e8efa65784f2508","7a74e2bf81484354960beb7efe0872a4"],"text":"\\begin{tabular}{l}\n(8) Sensory \\\\\nSensation or grimace to pin prick when tested, or withdrawal from noxdous stimusus in the obtunded or aphasic patlent. Only sensory loss attributed to stroke is scored as abonomal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, \"severe or fotal,\" should only be given when a severe or total loss of sensation can be clearly demonstrated. Stuporous and aphasic patients will therefore probably score 1 or 0 . The patient with brain stem stroke who has bilateral loss of sersation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (tem 13-3) are artitrarily given a 2 on this them. Coma Score \"2\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(8) Sensory \\\\\nSensation or grimace to pin prick when tested, or withdrawal from noxdous stimusus in the obtunded or aphasic patlent. Only sensory loss attributed to stroke is scored as abonomal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, \"severe or fotal,\" should only be given when a severe or total loss of sensation can be clearly demonstrated. Stuporous and aphasic patients will therefore probably score 1 or 0 . The patient with brain stem stroke who has bilateral loss of sersation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (tem 13-3) are artitrarily given a 2 on this them. Coma Score \"2\".\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.023615889106870548,"confidence_rate":0.9916320664396696},{"cnt":[[762,514],[879,514],[879,540],[762,540]],"region":{"top_left_x":761,"top_left_y":514,"width":119,"height":27},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"beec94b8212d4880a13fd437c2639064","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"(8) Sensory","text_display":"(8) Sensory","confidence":1,"confidence_rate":1},{"cnt":[[523,552],[1114,552],[1114,576],[523,576]],"region":{"top_left_x":523,"top_left_y":552,"width":591,"height":24},"line":18,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4efc2228954146c8b70f969f6dcebd97","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"Sensation or grimace to pin prick when tested, or withdrawal from noxdous","text_display":"\nSensation or grimace to pin prick when tested, or withdrawal from noxdous","confidence":0.7509182086674687,"confidence_rate":0.9963341901232214},{"cnt":[[523,574],[1116,574],[1116,597],[523,597]],"region":{"top_left_x":523,"top_left_y":574,"width":594,"height":24},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9271ff9e6d9d439a97070e71ab0d5fc4","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"stimusus in the obtunded or aphasic patlent. Only sensory loss attributed to","text_display":" stimusus in the obtunded or aphasic patlent. Only sensory loss attributed to","confidence":0.5060949347430543,"confidence_rate":0.9916274563797836},{"cnt":[[528,593],[1112,593],[1112,617],[528,617]],"region":{"top_left_x":528,"top_left_y":593,"width":585,"height":24},"line":20,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"58e61c0e9a534071a0e54590d500194c","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"stroke is scored as abonomal and the examiner should test as many body","text_display":" stroke is scored as abonomal and the examiner should test as many body","confidence":0.8029389271537868,"confidence_rate":0.9970779226194515},{"cnt":[[528,615],[1111,615],[1111,638],[528,638]],"region":{"top_left_x":528,"top_left_y":615,"width":583,"height":24},"line":21,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c18016ce287445e5a9a87675488c63c1","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"areas [arms (not hands), legs, trunk, face] as needed to accurately check","text_display":" areas [arms (not hands), legs, trunk, face] as needed to accurately check","confidence":0.9912281036376953,"confidence_rate":0.9998870500213322},{"cnt":[[527,637],[1111,637],[1111,659],[527,659]],"region":{"top_left_x":527,"top_left_y":636,"width":584,"height":23},"line":22,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3a0aeed551ef4d34956f40da3028ecfa","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"for hemisensory loss. A score of 2, \"severe or fotal,\" should only be given","text_display":" for hemisensory loss. A score of 2, \"severe or fotal,\" should only be given","confidence":0.43695135764655224,"confidence_rate":0.9897042008715242},{"cnt":[[542,656],[1095,656],[1095,679],[542,679]],"region":{"top_left_x":542,"top_left_y":656,"width":553,"height":24},"line":23,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"97704b79d02e42818d7b33db8c476fa5","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"when a severe or total loss of sensation can be clearly demonstrated.","text_display":" when a severe or total loss of sensation can be clearly demonstrated.","confidence":0.9637078849249209,"confidence_rate":0.9995005699698333},{"cnt":[[531,675],[1107,675],[1107,698],[531,698]],"region":{"top_left_x":531,"top_left_y":675,"width":576,"height":24},"line":24,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"368cd169a9614cc4b7419431bb1b0b42","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"Stuporous and aphasic patients will therefore probably score 1 or 0 . The","text_display":" Stuporous and aphasic patients will therefore probably score 1 or 0 . The","confidence":0.5343509163929175,"confidence_rate":0.9925670181110829},{"cnt":[[523,697],[1115,697],[1115,722],[523,722]],"region":{"top_left_x":523,"top_left_y":696,"width":593,"height":26},"line":25,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6b2b5bef30b8414fb825126e5790dbbc","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"patient with brain stem stroke who has bilateral loss of sersation is scored","text_display":" patient with brain stem stroke who has bilateral loss of sersation is scored","confidence":0.45601366452975994,"confidence_rate":0.9903526091165226},{"cnt":[[528,719],[1111,719],[1111,742],[528,742]],"region":{"top_left_x":528,"top_left_y":718,"width":583,"height":25},"line":26,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d69f6df8be744c149e8efa65784f2508","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"2. If the patent does not respond and is quadriplegic score 2. Patients in","text_display":" 2. If the patent does not respond and is quadriplegic score 2. Patients in","confidence":0.8609229878019932,"confidence_rate":0.9981062230119616},{"cnt":[[528,739],[1111,739],[1111,762],[528,762]],"region":{"top_left_x":528,"top_left_y":739,"width":583,"height":24},"line":27,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7a74e2bf81484354960beb7efe0872a4","type":"text","conversion_output":false,"parent_id":"7fbb901b5732444db37b84e1928a7ceb","text":"coma (tem 13-3) are artitrarily given a 2 on this them. Coma Score \"2\".","text_display":" coma (tem 13-3) are artitrarily given a 2 on this them. Coma Score \"2\".","confidence":0.023615889106870548,"confidence_rate":0.9536909235128669},{"cnt":[[1133,536],[1790,536],[1790,742],[1133,742]],"region":{"top_left_x":1132,"top_left_y":536,"width":659,"height":207},"line":28,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a8150b30996140dc982c5dca172d3dac","type":"complex_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","children_ids":["693747f1912b49d9bdae2dfe4dc480af","b0e3cacb864c4012bcb912b4a7376968","02e993c5aa7d488e8db68f03dfd16c05","e43a1c7824d4443590aeb06c76ca3d98","3a9e11372da848ebb9a6dc3391a5aeea","45fccfcfbee04bb297d612169043b298","f5627da4c70045c89087bbb7318bbef7","fa844b3476aa471eb48ed30560d96081","72ac6a4e7a1847dfb11b0ced7edfd3cf"],"text":"◯ \\(0=\\) Normal: no sensory loss\n◯ \\(1=\\) Midd to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side: or there is a loss of superficial pain with pinprick but patent is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg","text_display":"◯ \\(0=\\) Normal: no sensory loss\n◯ \\(1=\\) Midd to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side: or there is a loss of superficial pain with pinprick but patent is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.4488835130263169,"confidence_rate":0.9966327654987744},{"cnt":[[1134,539],[1168,539],[1168,573],[1134,573]],"region":{"top_left_x":1134,"top_left_y":538,"width":35,"height":35},"line":29,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"693747f1912b49d9bdae2dfe4dc480af","type":"form_field","conversion_output":false,"parent_id":"a8150b30996140dc982c5dca172d3dac","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1171,550],[1417,550],[1417,578],[1171,578]],"region":{"top_left_x":1171,"top_left_y":549,"width":246,"height":30},"line":30,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b0e3cacb864c4012bcb912b4a7376968","type":"text","conversion_output":false,"parent_id":"a8150b30996140dc982c5dca172d3dac","text":"\\(0=\\) Normal: no sensory loss","text_display":" \\(0=\\) Normal: no sensory loss","confidence":0.8697337216599099,"confidence_rate":0.9953585323501827},{"cnt":[[1134,585],[1170,585],[1170,618],[1134,618]],"region":{"top_left_x":1134,"top_left_y":585,"width":36,"height":33},"line":31,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"02e993c5aa7d488e8db68f03dfd16c05","type":"form_field","conversion_output":false,"parent_id":"a8150b30996140dc982c5dca172d3dac","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1172,593],[1788,593],[1788,622],[1172,622]],"region":{"top_left_x":1172,"top_left_y":593,"width":616,"height":29},"line":32,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e43a1c7824d4443590aeb06c76ca3d98","type":"text","conversion_output":false,"parent_id":"a8150b30996140dc982c5dca172d3dac","text":"\\(1=\\) Midd to moderate sensory loss; patient feels pinprick is less sharp","text_display":" \\(1=\\) Midd to moderate sensory loss; patient feels pinprick is less sharp","confidence":0.880523375235498,"confidence_rate":0.9982820341022923},{"cnt":[[1190,623],[1782,623],[1782,649],[1190,649]],"region":{"top_left_x":1190,"top_left_y":623,"width":593,"height":27},"line":33,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3a9e11372da848ebb9a6dc3391a5aeea","type":"text","conversion_output":false,"parent_id":"a8150b30996140dc982c5dca172d3dac","text":"or is dull on the affected side: or there is a loss of superficial pain","text_display":" or is dull on the affected side: or there is a loss of superficial pain","confidence":0.4488835130263169,"confidence_rate":0.989515977924494},{"cnt":[[1189,647],[1711,647],[1711,674],[1189,674]],"region":{"top_left_x":1188,"top_left_y":646,"width":524,"height":28},"line":34,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"45fccfcfbee04bb297d612169043b298","type":"text","conversion_output":false,"parent_id":"a8150b30996140dc982c5dca172d3dac","text":"with pinprick but patent is aware he/she is being touched","text_display":" with pinprick but patent is aware he/she is being touched","confidence":0.8935546875,"confidence_rate":0.9981863605010955},{"cnt":[[1134,675],[1168,675],[1168,709],[1134,709]],"region":{"top_left_x":1134,"top_left_y":675,"width":35,"height":35},"line":35,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f5627da4c70045c89087bbb7318bbef7","type":"form_field","conversion_output":false,"parent_id":"a8150b30996140dc982c5dca172d3dac","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1170,686],[1717,686],[1717,713],[1170,713]],"region":{"top_left_x":1169,"top_left_y":686,"width":548,"height":28},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fa844b3476aa471eb48ed30560d96081","type":"text","conversion_output":false,"parent_id":"a8150b30996140dc982c5dca172d3dac","text":"2=Severe to total sensory loss; patient is not aware of being","text_display":" 2=Severe to total sensory loss; patient is not aware of being","confidence":0.99951171875,"confidence_rate":0.9999926000198329},{"cnt":[[1189,713],[1468,713],[1468,739],[1189,739]],"region":{"top_left_x":1188,"top_left_y":713,"width":281,"height":27},"line":37,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"72ac6a4e7a1847dfb11b0ced7edfd3cf","type":"text","conversion_output":false,"parent_id":"a8150b30996140dc982c5dca172d3dac","text":"touched in the face, arm \\& leg","text_display":" touched in the face, arm \\& leg","confidence":0.94873046875,"confidence_rate":0.9984974004125536},{"cnt":[[455,926],[490,926],[490,951],[455,951]],"region":{"top_left_x":454,"top_left_y":926,"width":37,"height":25},"line":38,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"67ecb5e4a9024d30a450adb470125f71","type":"simple_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"19","text_display":"19","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[515,783],[1125,783],[1125,1080],[515,1080]],"region":{"top_left_x":514,"top_left_y":782,"width":611,"height":299},"line":39,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a206a5173d384f24a04b7fe88fc33780","type":"complex_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","children_ids":["c80aa4ca22c74d12a6fcbcdf0245e8b9","c2ea9ea04bce49b0b08cadd6e710ba81","44a354b7f4924ffa8853f5538bf39b4c","0b7510a15456435685ce3b35618d1499","1aebf486684a470b9c17966e0b41adf5","ae151ff8392445f2b3e047305728c5f8","1085239e4c9f4cda8cc524cc68395715","77f942aceb5e487fbc9c67f56e09e4c3","9cea34b68bcf48fc83a406aec6986412","47a7aabbce054f1ab18e694d7a974522","1ab9a20504c84fd389219a807c1a589f","81b3bec4c18c4015a3552991ab7b84cf","f8c7849002a645d5abc7fa7cbdeec1da"],"text":"\\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of information about comprehension will be obtained during the preceding sections of the examination. The patient is asked to describe what is happening in the attached ploture, to name the thems on the attached naming sheet, and to read from the attached ilst of sentences. Comprehension is judged from responses here as well as to all of the commands in the preceding general neurciogical exam. if visual loss Interferes with the tests, ask the patent to identity objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to witte. The patlent in coma (question 13-3) will arbitrarily score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a score of 3 should be used only if the patent is mute and follows no one step commands. Coma Score '3'.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of information about comprehension will be obtained during the preceding sections of the examination. The patient is asked to describe what is happening in the attached ploture, to name the thems on the attached naming sheet, and to read from the attached ilst of sentences. Comprehension is judged from responses here as well as to all of the commands in the preceding general neurciogical exam. if visual loss Interferes with the tests, ask the patent to identity objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to witte. The patlent in coma (question 13-3) will arbitrarily score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a score of 3 should be used only if the patent is mute and follows no one step commands. Coma Score '3'.\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.09136247720657809,"confidence_rate":0.9937895310022854},{"cnt":[[725,784],[915,784],[915,813],[725,813]],"region":{"top_left_x":724,"top_left_y":784,"width":191,"height":29},"line":40,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c80aa4ca22c74d12a6fcbcdf0245e8b9","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"(9) Best Language","text_display":"(9) Best Language","confidence":1,"confidence_rate":1},{"cnt":[[515,822],[1122,822],[1122,848],[515,848]],"region":{"top_left_x":514,"top_left_y":822,"width":608,"height":27},"line":41,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c2ea9ea04bce49b0b08cadd6e710ba81","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"A great deal of information about comprehension will be obtained during the","text_display":"\nA great deal of information about comprehension will be obtained during the","confidence":0.8445227804503799,"confidence_rate":0.9978899347240042},{"cnt":[[534,847],[1103,847],[1103,870],[534,870]],"region":{"top_left_x":533,"top_left_y":847,"width":570,"height":24},"line":42,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"44a354b7f4924ffa8853f5538bf39b4c","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"preceding sections of the examination. The patient is asked to describe","text_display":" preceding sections of the examination. The patient is asked to describe","confidence":0.8183983596208343,"confidence_rate":0.9973665516679632},{"cnt":[[550,866],[1089,866],[1089,892],[550,892]],"region":{"top_left_x":550,"top_left_y":866,"width":540,"height":27},"line":43,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0b7510a15456435685ce3b35618d1499","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"what is happening in the attached ploture, to name the thems on the","text_display":" what is happening in the attached ploture, to name the thems on the","confidence":0.27987554502406115,"confidence_rate":0.9824692302262451},{"cnt":[[534,888],[1103,888],[1103,911],[534,911]],"region":{"top_left_x":533,"top_left_y":887,"width":570,"height":25},"line":44,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1aebf486684a470b9c17966e0b41adf5","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"attached naming sheet, and to read from the attached ilst of sentences.","text_display":" attached naming sheet, and to read from the attached ilst of sentences.","confidence":0.8645072006802625,"confidence_rate":0.9980861016779299},{"cnt":[[542,907],[1097,907],[1097,930],[542,930]],"region":{"top_left_x":542,"top_left_y":907,"width":556,"height":24},"line":45,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ae151ff8392445f2b3e047305728c5f8","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"Comprehension is judged from responses here as well as to all of the","text_display":" Comprehension is judged from responses here as well as to all of the","confidence":0.9854110694234761,"confidence_rate":0.999798699777256},{"cnt":[[545,929],[1093,929],[1093,952],[545,952]],"region":{"top_left_x":544,"top_left_y":928,"width":550,"height":25},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1085239e4c9f4cda8cc524cc68395715","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"commands in the preceding general neurciogical exam. if visual loss","text_display":" commands in the preceding general neurciogical exam. if visual loss","confidence":0.4693587073005324,"confidence_rate":0.9895496004130223},{"cnt":[[537,949],[1103,949],[1103,974],[537,974]],"region":{"top_left_x":536,"top_left_y":949,"width":567,"height":25},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"77f942aceb5e487fbc9c67f56e09e4c3","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"Interferes with the tests, ask the patent to identity objects placed in the","text_display":" Interferes with the tests, ask the patent to identity objects placed in the","confidence":0.645301498864896,"confidence_rate":0.9945394926743323},{"cnt":[[523,970],[1114,970],[1114,993],[523,993]],"region":{"top_left_x":523,"top_left_y":969,"width":591,"height":25},"line":48,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9cea34b68bcf48fc83a406aec6986412","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"hand, repeat, and produce speech. The intubated patent should be asked","text_display":" hand, repeat, and produce speech. The intubated patent should be asked","confidence":0.9316983422903102,"confidence_rate":0.9990571623009238},{"cnt":[[523,989],[1114,989],[1114,1013],[523,1013]],"region":{"top_left_x":523,"top_left_y":988,"width":591,"height":26},"line":49,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"47a7aabbce054f1ab18e694d7a974522","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"to witte. The patlent in coma (question 13-3) will arbitrarily score 3 on this","text_display":" to witte. The patlent in coma (question 13-3) will arbitrarily score 3 on this","confidence":0.09136247720657809,"confidence_rate":0.972558884186131},{"cnt":[[515,1011],[1122,1011],[1122,1034],[515,1034]],"region":{"top_left_x":514,"top_left_y":1010,"width":608,"height":24},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1ab9a20504c84fd389219a807c1a589f","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"Item. The examiner must choose a score in the patient with stupor or limited","text_display":" Item. The examiner must choose a score in the patient with stupor or limited","confidence":0.7740946445753976,"confidence_rate":0.9968437429288247},{"cnt":[[523,1033],[1116,1033],[1116,1056],[523,1056]],"region":{"top_left_x":523,"top_left_y":1032,"width":594,"height":24},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"81b3bec4c18c4015a3552991ab7b84cf","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"cooperation but a score of 3 should be used only if the patent is mute and","text_display":" cooperation but a score of 3 should be used only if the patent is mute and","confidence":0.7877630453374032,"confidence_rate":0.9970949845978467},{"cnt":[[616,1052],[1020,1052],[1020,1078],[616,1078]],"region":{"top_left_x":615,"top_left_y":1051,"width":405,"height":27},"line":52,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f8c7849002a645d5abc7fa7cbdeec1da","type":"text","conversion_output":false,"parent_id":"a206a5173d384f24a04b7fe88fc33780","text":"follows no one step commands. Coma Score '3'.","text_display":" follows no one step commands. Coma Score '3'.","confidence":0.7551781277974521,"confidence_rate":0.9943997078966124},{"cnt":[[1131,797],[1790,797],[1790,1093],[1131,1093]],"region":{"top_left_x":1131,"top_left_y":796,"width":660,"height":297},"line":53,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8cee07e0f49045dfb2410f0a31e6f578","type":"complex_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","children_ids":["d48d2d0c96db44608b85498b90ebf158","30c08ea163a84e719cda0028cd637516","9824891db0fc47f581c65d4f0d16f526","92f1e39caf674e29b9877a6623291a4d","fbd9a54e37aa44b6bda0cc1f1c36ebd0","99dba560151e42cd8f26711c0d998b2d","1d3f4266a7844f6da90e1da7b21c6ccb","62dc646d56d64e9fb693065d4ab1519e","e7494897698743099c8c20a628c0e9e6","b2f130f4a31b460abee3dce0c994cb53","2f7190637c9d49498f09ae94ad4b256c","ca5eb6b506af4da79dfcc89c4dab4d6d","4854974826b2421aba2d98e7ae6a2633"],"text":"◯ \\(0=\\) No aphasia normal\n◯ 1=Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2 =Severe aphasia; all communication is through fragmentary expression; great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension","text_display":"◯ \\(0=\\) No aphasia normal\n◯ 1=Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2 =Severe aphasia; all communication is through fragmentary expression; great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.7424507141113281,"confidence_rate":0.9980776777027138},{"cnt":[[1134,801],[1168,801],[1168,835],[1134,835]],"region":{"top_left_x":1134,"top_left_y":800,"width":35,"height":35},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d48d2d0c96db44608b85498b90ebf158","type":"form_field","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1171,810],[1376,810],[1376,838],[1171,838]],"region":{"top_left_x":1171,"top_left_y":810,"width":205,"height":28},"line":55,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"30c08ea163a84e719cda0028cd637516","type":"text","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"\\(0=\\) No aphasia normal","text_display":" \\(0=\\) No aphasia normal","confidence":0.7741498373942013,"confidence_rate":0.9893904395053668},{"cnt":[[1134,843],[1170,843],[1170,877],[1134,877]],"region":{"top_left_x":1134,"top_left_y":842,"width":36,"height":36},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9824891db0fc47f581c65d4f0d16f526","type":"form_field","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1172,854],[1788,854],[1788,881],[1172,881]],"region":{"top_left_x":1172,"top_left_y":853,"width":616,"height":29},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"92f1e39caf674e29b9877a6623291a4d","type":"text","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"1=Mild to moderate aphasia; some obvious loss of fluency or facility","text_display":" 1=Mild to moderate aphasia; some obvious loss of fluency or facility","confidence":0.9990234375,"confidence_rate":0.999986615984802},{"cnt":[[1190,881],[1695,881],[1695,907],[1190,907]],"region":{"top_left_x":1190,"top_left_y":881,"width":505,"height":27},"line":58,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fbd9a54e37aa44b6bda0cc1f1c36ebd0","type":"text","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"of comprehension without significant limitation on ideas","text_display":" of comprehension without significant limitation on ideas","confidence":0.99951171875,"confidence_rate":0.9999919934665097},{"cnt":[[1189,906],[1493,906],[1493,932],[1189,932]],"region":{"top_left_x":1188,"top_left_y":905,"width":305,"height":27},"line":59,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"99dba560151e42cd8f26711c0d998b2d","type":"text","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"expressed on form of expression","text_display":" expressed on form of expression","confidence":1,"confidence_rate":1},{"cnt":[[1134,934],[1168,934],[1168,968],[1134,968]],"region":{"top_left_x":1134,"top_left_y":934,"width":35,"height":35},"line":60,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1d3f4266a7844f6da90e1da7b21c6ccb","type":"form_field","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1170,943],[1726,943],[1726,971],[1170,971]],"region":{"top_left_x":1169,"top_left_y":942,"width":558,"height":30},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"62dc646d56d64e9fb693065d4ab1519e","type":"text","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"2 =Severe aphasia; all communication is through fragmentary","text_display":" 2 =Severe aphasia; all communication is through fragmentary","confidence":0.7424507141113281,"confidence_rate":0.9952841896142608},{"cnt":[[1190,973],[1771,973],[1771,998],[1190,998]],"region":{"top_left_x":1190,"top_left_y":972,"width":582,"height":27},"line":62,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e7494897698743099c8c20a628c0e9e6","type":"text","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"expression; great need for inference, questioning, and guessing","text_display":" expression; great need for inference, questioning, and guessing","confidence":1,"confidence_rate":1},{"cnt":[[1189,997],[1703,997],[1703,1023],[1189,1023]],"region":{"top_left_x":1188,"top_left_y":997,"width":516,"height":27},"line":63,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b2f130f4a31b460abee3dce0c994cb53","type":"text","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"by the listener; listener carries burden of communication","text_display":" by the listener; listener carries burden of communication","confidence":0.9234139738837257,"confidence_rate":0.9987157022567192},{"cnt":[[1134,1027],[1168,1027],[1168,1061],[1134,1061]],"region":{"top_left_x":1134,"top_left_y":1027,"width":35,"height":35},"line":64,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2f7190637c9d49498f09ae94ad4b256c","type":"form_field","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1170,1037],[1662,1037],[1662,1064],[1170,1064]],"region":{"top_left_x":1169,"top_left_y":1036,"width":494,"height":28},"line":65,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ca5eb6b506af4da79dfcc89c4dab4d6d","type":"text","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"3=Mute, global aphasia; no usable speech or auditory","text_display":" 3=Mute, global aphasia; no usable speech or auditory","confidence":0.9653966192854568,"confidence_rate":0.9993823617356584},{"cnt":[[1189,1063],[1335,1063],[1335,1091],[1189,1091]],"region":{"top_left_x":1188,"top_left_y":1062,"width":147,"height":30},"line":66,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4854974826b2421aba2d98e7ae6a2633","type":"text","conversion_output":false,"parent_id":"8cee07e0f49045dfb2410f0a31e6f578","text":"comprehension","text_display":" comprehension","confidence":1,"confidence_rate":1},{"cnt":[[455,1221],[490,1221],[490,1245],[455,1245]],"region":{"top_left_x":454,"top_left_y":1220,"width":37,"height":26},"line":67,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f622ae23bcff4e3b8b47373652ce3119","type":"simple_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"20","text_display":"20","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[515,1129],[1125,1129],[1125,1333],[515,1333]],"region":{"top_left_x":514,"top_left_y":1129,"width":611,"height":204},"line":68,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1473939888724932a6a7fd5d3bf17cf5","type":"complex_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","children_ids":["26d692a0e94c4ba0a40f1472f01da6a5","a9baa6edceef4fd39f98e0b9a48149e3","0eacd18f9f4c46f2ba2ea3d89311142c","176b541a1ede42ad8430ff5f8287c89d","e70badd5bf8547ebb715e4f30aff85ca","7c9aa99612134becbd13887ec43e99a4","f6c19618bb7042b4a0b49d52549e0333","d514fee1d9184709985426e77adfc351"],"text":"\\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be normal an adequate sample of speech must be colained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the clarty of artioulation of spontaneous speech can be rated. Only if the patient is intubated or has other physical barrier to producing speech, may the liem be not scored, and the examiner must clearly witle an explanation. Do not teil the parlent why heishe is being tested. Coma Score \"2\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be normal an adequate sample of speech must be colained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the clarty of artioulation of spontaneous speech can be rated. Only if the patient is intubated or has other physical barrier to producing speech, may the liem be not scored, and the examiner must clearly witle an explanation. Do not teil the parlent why heishe is being tested. Coma Score \"2\".\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.10391858031212715,"confidence_rate":0.9881074051052188},{"cnt":[[747,1136],[893,1136],[893,1165],[747,1165]],"region":{"top_left_x":746,"top_left_y":1136,"width":147,"height":29},"line":69,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"26d692a0e94c4ba0a40f1472f01da6a5","type":"text","conversion_output":false,"parent_id":"1473939888724932a6a7fd5d3bf17cf5","text":"(10) Dysarthria","text_display":"(10) Dysarthria","confidence":1,"confidence_rate":1},{"cnt":[[528,1185],[1108,1185],[1108,1209],[528,1209]],"region":{"top_left_x":528,"top_left_y":1185,"width":581,"height":24},"line":70,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a9baa6edceef4fd39f98e0b9a48149e3","type":"text","conversion_output":false,"parent_id":"1473939888724932a6a7fd5d3bf17cf5","text":"If patient is thought to be normal an adequate sample of speech must be","text_display":"\nIf patient is thought to be normal an adequate sample of speech must be","confidence":0.5634702095478306,"confidence_rate":0.9924805084612005},{"cnt":[[523,1207],[1118,1207],[1118,1230],[523,1230]],"region":{"top_left_x":523,"top_left_y":1207,"width":595,"height":24},"line":71,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0eacd18f9f4c46f2ba2ea3d89311142c","type":"text","conversion_output":false,"parent_id":"1473939888724932a6a7fd5d3bf17cf5","text":"colained by asking patient to read or repeat words from the attached list. If","text_display":" colained by asking patient to read or repeat words from the attached list. If","confidence":0.21155832252870466,"confidence_rate":0.9812361459097039},{"cnt":[[531,1226],[1107,1226],[1107,1249],[531,1249]],"region":{"top_left_x":531,"top_left_y":1226,"width":576,"height":24},"line":72,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"176b541a1ede42ad8430ff5f8287c89d","type":"text","conversion_output":false,"parent_id":"1473939888724932a6a7fd5d3bf17cf5","text":"the patient has severe aphasia, the clarty of artioulation of spontaneous","text_display":" the patient has severe aphasia, the clarty of artioulation of spontaneous","confidence":0.10391858031212715,"confidence_rate":0.9713897188991749},{"cnt":[[528,1247],[1111,1247],[1111,1270],[528,1270]],"region":{"top_left_x":528,"top_left_y":1246,"width":583,"height":24},"line":73,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e70badd5bf8547ebb715e4f30aff85ca","type":"text","conversion_output":false,"parent_id":"1473939888724932a6a7fd5d3bf17cf5","text":"speech can be rated. Only if the patient is intubated or has other physical","text_display":" speech can be rated. Only if the patient is intubated or has other physical","confidence":0.6311088747824286,"confidence_rate":0.9942630583596789},{"cnt":[[518,1267],[1122,1267],[1122,1290],[518,1290]],"region":{"top_left_x":517,"top_left_y":1267,"width":605,"height":24},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7c9aa99612134becbd13887ec43e99a4","type":"text","conversion_output":false,"parent_id":"1473939888724932a6a7fd5d3bf17cf5","text":"barrier to producing speech, may the liem be not scored, and the examiner","text_display":" barrier to producing speech, may the liem be not scored, and the examiner","confidence":0.897312081928554,"confidence_rate":0.9986118418199247},{"cnt":[[518,1289],[1122,1289],[1122,1312],[518,1312]],"region":{"top_left_x":517,"top_left_y":1289,"width":605,"height":24},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f6c19618bb7042b4a0b49d52549e0333","type":"text","conversion_output":false,"parent_id":"1473939888724932a6a7fd5d3bf17cf5","text":"must clearly witle an explanation. Do not teil the parlent why heishe is being","text_display":" must clearly witle an explanation. Do not teil the parlent why heishe is being","confidence":0.12233861503717709,"confidence_rate":0.9750048810837567},{"cnt":[[717,1308],[925,1308],[925,1329],[717,1329]],"region":{"top_left_x":716,"top_left_y":1308,"width":210,"height":21},"line":76,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d514fee1d9184709985426e77adfc351","type":"text","conversion_output":false,"parent_id":"1473939888724932a6a7fd5d3bf17cf5","text":"tested. Coma Score \"2\".","text_display":" tested. Coma Score \"2\".","confidence":0.8051989475130683,"confidence_rate":0.9922917941879773},{"cnt":[[1133,1114],[1789,1114],[1789,1357],[1133,1357]],"region":{"top_left_x":1132,"top_left_y":1114,"width":657,"height":244},"line":77,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c31a655582c14dce8a2c9e456e31ed6c","type":"complex_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","children_ids":["61b1a786e8144fc1bc72bf1bb880561c","87de536e80d348feb88d92c53e3672c7","d46512c98bb74a3d97fd8f6e9e287d3e","ffffa51dba5f4d88913ad9816e024201","9e06b54ac4fc48d7a384e13ec2cae6e3","4eeb4f5a05ab499cab60e74d17784e86","d1c673f900fa433b8dae84d76ceab18d","134bc11ad04347c7b11518dbaf6ea8be","5efb4b9b4547473d8a9b132956fde037","eb22190d7b2b4cc4ae664a8918808341","f123f876d80846068b25dff3d1700001"],"text":"◯ 0=Normal\n◯ \\(1=\\) Mild to moderate: patient slurs at least some words and at worst. can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mute/ anarthric\n◯ Intubated or other physical barrier.","text_display":"◯ 0=Normal\n◯ \\(1=\\) Mild to moderate: patient slurs at least some words and at worst. can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mute/ anarthric\n◯ Intubated or other physical barrier.","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.7045633737208841,"confidence_rate":0.9991811440724688},{"cnt":[[1134,1117],[1168,1117],[1168,1151],[1134,1151]],"region":{"top_left_x":1134,"top_left_y":1117,"width":35,"height":35},"line":78,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"61b1a786e8144fc1bc72bf1bb880561c","type":"form_field","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1171,1127],[1264,1127],[1264,1151],[1171,1151]],"region":{"top_left_x":1171,"top_left_y":1126,"width":93,"height":26},"line":79,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"87de536e80d348feb88d92c53e3672c7","type":"text","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"0=Normal","text_display":" 0=Normal","confidence":0.9965846532722935,"confidence_rate":0.9997368659844452},{"cnt":[[1134,1161],[1170,1161],[1170,1198],[1134,1198]],"region":{"top_left_x":1134,"top_left_y":1160,"width":36,"height":38},"line":80,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d46512c98bb74a3d97fd8f6e9e287d3e","type":"form_field","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1172,1172],[1782,1172],[1782,1198],[1172,1198]],"region":{"top_left_x":1172,"top_left_y":1171,"width":611,"height":27},"line":81,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ffffa51dba5f4d88913ad9816e024201","type":"text","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"\\(1=\\) Mild to moderate: patient slurs at least some words and at worst.","text_display":" \\(1=\\) Mild to moderate: patient slurs at least some words and at worst.","confidence":0.7045633737208841,"confidence_rate":0.9951482386127226},{"cnt":[[1179,1196],[1531,1196],[1531,1225],[1179,1225]],"region":{"top_left_x":1179,"top_left_y":1196,"width":353,"height":29},"line":82,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9e06b54ac4fc48d7a384e13ec2cae6e3","type":"text","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"can be understood with some difficulty","text_display":" can be understood with some difficulty","confidence":1,"confidence_rate":1},{"cnt":[[1134,1229],[1170,1229],[1170,1263],[1134,1263]],"region":{"top_left_x":1134,"top_left_y":1229,"width":36,"height":35},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4eeb4f5a05ab499cab60e74d17784e86","type":"form_field","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1172,1237],[1760,1237],[1760,1266],[1172,1266]],"region":{"top_left_x":1172,"top_left_y":1237,"width":589,"height":29},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d1c673f900fa433b8dae84d76ceab18d","type":"text","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"2=Severe; patient's speech is so slurred as to be unintelligible in","text_display":" 2=Severe; patient's speech is so slurred as to be unintelligible in","confidence":0.98828125,"confidence_rate":0.9998362917939837},{"cnt":[[1202,1264],[1785,1264],[1785,1293],[1202,1293]],"region":{"top_left_x":1202,"top_left_y":1264,"width":583,"height":30},"line":85,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"134bc11ad04347c7b11518dbaf6ea8be","type":"text","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"the absence of or out of proportion to any dysphasia, or is mute/","text_display":" the absence of or out of proportion to any dysphasia, or is mute/","confidence":0.97021484375,"confidence_rate":0.9995681255188202},{"cnt":[[1202,1289],[1288,1289],[1288,1312],[1202,1312]],"region":{"top_left_x":1202,"top_left_y":1289,"width":87,"height":24},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5efb4b9b4547473d8a9b132956fde037","type":"text","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"anarthric","text_display":" anarthric","confidence":1,"confidence_rate":1},{"cnt":[[1134,1318],[1168,1318],[1168,1353],[1134,1353]],"region":{"top_left_x":1134,"top_left_y":1317,"width":35,"height":37},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"eb22190d7b2b4cc4ae664a8918808341","type":"form_field","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1175,1330],[1493,1330],[1493,1356],[1175,1356]],"region":{"top_left_x":1175,"top_left_y":1329,"width":318,"height":27},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f123f876d80846068b25dff3d1700001","type":"text","conversion_output":false,"parent_id":"c31a655582c14dce8a2c9e456e31ed6c","text":"Intubated or other physical barrier.","text_display":" Intubated or other physical barrier.","confidence":0.99951171875,"confidence_rate":0.9999880878636791},{"cnt":[[460,1393],[490,1393],[490,1419],[460,1419]],"region":{"top_left_x":460,"top_left_y":1392,"width":31,"height":27},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bf1ac6880537466f8cd16d5c7fd5567a","type":"simple_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"21","text_display":"21","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[561,1393],[1078,1393],[1078,1421],[561,1421]],"region":{"top_left_x":561,"top_left_y":1392,"width":518,"height":30},"line":90,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c0aefafbd9ce4cda930aa67779de0e3e","type":"simple_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"Explain if intubated or other physical barrier (Dysarthria):","text_display":"Explain if intubated or other physical barrier (Dysarthria):","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[455,1562],[490,1562],[490,1586],[455,1586]],"region":{"top_left_x":454,"top_left_y":1561,"width":37,"height":26},"line":91,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"398426fc2d6547318e0cef80f588f3c5","type":"simple_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","text":"22","text_display":"22","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[513,1469],[1125,1469],[1125,1678],[513,1678]],"region":{"top_left_x":513,"top_left_y":1469,"width":612,"height":209},"line":92,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"896f118f5bd7401d95149163f27b775c","type":"complex_cell","conversion_output":false,"parent_id":"20bc3e830f374bf7a6dc08d620878819","children_ids":["f63dfb8e296545819b628a92fdca5336","483b183f58a74d42a6ddeff6c8adfd62","67f4211e21f74fbb95f77b5829280b8a","a9c6e36a17d6488eadf2550de927b00b","6b8943de523b45b3b975d84f6690bcf0","c48c1a5afb4e4efc8fea01ac0e8eb877","1bee677bafce4df59308368be7ce5959","29b76addc80346f4833108827d5065df"],"text":"\\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumficient information to Identiy neglect may be obtained during the proor testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the cutaneous stimull are normal, the score is normal. If the patent has aphasla but does appear to attend to both sides, the score is nomal. The presence of visual spallal neglect or anosagnosla may also be taken as evidence of abonormally. Since the abnormality is scored only if present, the item is never untestable. Coma Score \" 2 \".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumficient information to Identiy neglect may be obtained during the proor testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the cutaneous stimull are normal, the score is normal. If the patent has aphasla but does appear to attend to both sides, the score is nomal. The presence of visual spallal neglect or anosagnosla may also be taken as evidence of abonormally. Since the abnormality is scored only if present, the item is never untestable. Coma Score \" 2 \".\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.08034118730937431,"confidence_rate":0.9895690602403822},{"cnt":[[634,1477],[1005,1477],[1005,1506],[634,1506]],"region":{"top_left_x":633,"top_left_y":1477,"width":372,"height":29},"line":93,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f63dfb8e296545819b628a92fdca5336","type":"text","conversion_output":false,"parent_id":"896f118f5bd7401d95149163f27b775c","text":"(11) Extinction and Inattention (Neglect)","text_display":"(11) Extinction and Inattention (Neglect)","confidence":0.99853515625,"confidence_rate":0.9999681327320658},{"cnt":[[528,1526],[1111,1526],[1111,1551],[528,1551]],"region":{"top_left_x":528,"top_left_y":1526,"width":583,"height":25},"line":94,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"483b183f58a74d42a6ddeff6c8adfd62","type":"text","conversion_output":false,"parent_id":"896f118f5bd7401d95149163f27b775c","text":"Sumficient information to Identiy neglect may be obtained during the proor","text_display":"\nSumficient information to Identiy neglect may be obtained during the proor","confidence":0.08034118730937431,"confidence_rate":0.9685866052180925},{"cnt":[[539,1548],[1100,1548],[1100,1571],[539,1571]],"region":{"top_left_x":539,"top_left_y":1548,"width":562,"height":24},"line":95,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"67f4211e21f74fbb95f77b5829280b8a","type":"text","conversion_output":false,"parent_id":"896f118f5bd7401d95149163f27b775c","text":"testing. If the patient has a severe visual loss preventing visual double","text_display":" testing. If the patient has a severe visual loss preventing visual double","confidence":0.8719522545840344,"confidence_rate":0.9982448675560897},{"cnt":[[518,1567],[1122,1567],[1122,1591],[518,1591]],"region":{"top_left_x":517,"top_left_y":1567,"width":605,"height":24},"line":96,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a9c6e36a17d6488eadf2550de927b00b","type":"text","conversion_output":false,"parent_id":"896f118f5bd7401d95149163f27b775c","text":"simultaneous stimulation, and the cutaneous stimull are normal, the score is","text_display":" simultaneous stimulation, and the cutaneous stimull are normal, the score is","confidence":0.4892130727297846,"confidence_rate":0.991212208834717},{"cnt":[[523,1586],[1114,1586],[1114,1610],[523,1610]],"region":{"top_left_x":523,"top_left_y":1586,"width":591,"height":24},"line":97,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6b8943de523b45b3b975d84f6690bcf0","type":"text","conversion_output":false,"parent_id":"896f118f5bd7401d95149163f27b775c","text":"normal. If the patent has aphasla but does appear to attend to both sides,","text_display":" normal. If the patent has aphasla but does appear to attend to both sides,","confidence":0.5545142681304968,"confidence_rate":0.9925637017777185},{"cnt":[[523,1608],[1116,1608],[1116,1631],[523,1631]],"region":{"top_left_x":523,"top_left_y":1608,"width":594,"height":24},"line":98,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c48c1a5afb4e4efc8fea01ac0e8eb877","type":"text","conversion_output":false,"parent_id":"896f118f5bd7401d95149163f27b775c","text":"the score is nomal. The presence of visual spallal neglect or anosagnosla","text_display":" the score is nomal. 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Since the abnormality is","confidence":0.19103799865894008,"confidence_rate":0.9781713312158505},{"cnt":[[539,1649],[1097,1649],[1097,1674],[539,1674]],"region":{"top_left_x":539,"top_left_y":1649,"width":559,"height":25},"line":100,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"29b76addc80346f4833108827d5065df","type":"text","conversion_output":false,"parent_id":"896f118f5bd7401d95149163f27b775c","text":"scored only if present, the item is never untestable. Coma Score \" 2 \".","text_display":" scored only if present, the item is never untestable. 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usual duties and activities\n◯ (2) Slight disability, unable to carry out all previous activities but able to look after own affairs without assistance\n◯ (3) Moderate disability requiring some help, but able to walk without assistance\n◯ (4) Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance\n◯ (5) Severe disability, bedridden, incontinent, and requiring constant nursing care and attention \\\\\n\\hline 2 & For response 2 above, specify the previous activities that can no longer be carried out: & \\\\\n\\hline 3 & \\begin{tabular}{l}\nName of assessor: \\\\\nThe assessor must be a study team member who has completed mRS certification.\n\\end{tabular} & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 1 & Modified Rankin Scale: & ◯ (D) No symptoms at all\n◯ (1) No significant disability despite symptoms, able to carry out all usual duties and activities\n◯ (2) Slight 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ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-188","page":188,"lines":[{"cnt":[[782,432],[1454,432],[1454,537],[782,537]],"region":{"top_left_x":782,"top_left_y":431,"width":673,"height":107},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"523b3d7f449244f488a01bff9547fa65","type":"section_header","conversion_output":false,"children_ids":["ba0a2c57e38540909cbad27a250cbd91","241f764c644844e7bc5fa7115d0ae792"],"text":"","text_display":""},{"cnt":[[975,438],[1227,438],[1227,488],[975,488]],"region":{"top_left_x":975,"top_left_y":438,"width":252,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba0a2c57e38540909cbad27a250cbd91","type":"text","conversion_output":true,"parent_id":"523b3d7f449244f488a01bff9547fa65","text":"Appendix 9","text_display":"\n\n\\section*{Appendix 9","confidence":1,"confidence_rate":1},{"cnt":[[786,477],[1450,477],[1450,535],[786,535]],"region":{"top_left_x":786,"top_left_y":476,"width":665,"height":59},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"241f764c644844e7bc5fa7115d0ae792","type":"text","conversion_output":true,"parent_id":"523b3d7f449244f488a01bff9547fa65","text":"Glasgow Outcome Scale (GOS)","text_display":" Glasgow Outcome Scale (GOS)}","confidence":0.8350412845611572,"confidence_rate":0.9943822727522684},{"cnt":[[524,610],[1734,610],[1734,645],[524,645]],"region":{"top_left_x":524,"top_left_y":610,"width":1210,"height":35},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"91081a75559e48bc8fe9db341037fb77","type":"text","conversion_output":true,"text":"Note: The scale presented here is based on the original article by Jennett and Bond. It has become common practice","text_display":"\n\nNote: The scale presented here is based on the original article by Jennett and Bond. It has become common practice","confidence":0.998046875,"confidence_rate":0.9999835712707866},{"cnt":[[524,640],[1738,640],[1738,677],[524,677]],"region":{"top_left_x":524,"top_left_y":640,"width":1215,"height":37},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"654f962e5f674ebea39f2514e1b87361","type":"text","conversion_output":true,"text":"in elinical trial administration, however, to use a modified version that places the scores in reverse order (i.e., \"good","text_display":" in elinical trial administration, however, to use a modified version that places the scores in reverse order (i.e., \"good","confidence":0.3994835671681189,"confidence_rate":0.992744050468649},{"cnt":[[524,675],[1008,675],[1008,707],[524,707]],"region":{"top_left_x":524,"top_left_y":674,"width":484,"height":33},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2fded3c7562a45d1a2810dd8cfb85edd","type":"text","conversion_output":true,"text":"recovery\" = 1 , \"moderate disability\" =2, etc.).","text_display":" recovery\" = 1 , \"moderate disability\" =2, etc.).","confidence":0.33785837364848703,"confidence_rate":0.9808092386300322},{"cnt":[[518,827],[1753,827],[1753,1525],[518,1525]],"region":{"top_left_x":517,"top_left_y":827,"width":1237,"height":699},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1fc2f32df45249c797a83473beda8036","type":"table","conversion_output":true,"children_ids":["7bc63e1819064f21ba56361da15fe090","39627fbeb5824b5f850abe6a6cacfa20","5571d8882c344918aded61aaa567d8e0","58f0969fb354444a8a22daf9caa042fb","d905f6523a8040f7af669e79583f3f18","d1eeea5f00e04f7393868afce4bfeb9a","91ad6d80f8c34bc6a9443277542b37b0","bcc9b6e433a24890b36f1dad8c5fb816","ae860f3003c443829d87cf50807c97a2","15658ed3723f4650a71ebf3db8b1e052","b68af52c788a4332912af450150c5f5b","741af2af94d24385b831666799c91343","05883b3fc55d458596175e0d6740875c","514c31e77ee44ce1a265c9ed1dbb178b","2b257b9773894529905326696940e5bc","f185292534ba49f3897994ec2398144c","90345911adea4ac1b74d847fa48f9b67","943c26bd70044a0a969ec6f49a5c375e","88b52a37a59e49188fe90013bf733c83","9287b54f2a8149cca995c73ecd630008"],"text":"\\begin{tabular}{|l|l|}\n\\hline Score & Description \\\\\n\\hline 1 & DEATH \\\\\n\\hline 2 & PERSISTENT VEGETATIVE STATE Patient exhibits no obvious cortical function. \\\\\n\\hline 3 & SEVERE DISABILITY (Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both. \\\\\n\\hline 4 & MODERATE DISABILITY (Disabled but independent). Patient is independent as far as daily life is concerned. The disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as intellectual and memory deficits and personality changes. \\\\\n\\hline 5 & \\begin{tabular}{l}\nGOOD RECOVERY \\\\\nResumption of normal activities even though there may be minor neurological or psychological deficits.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Score & Description \\\\\n\\hline 1 & DEATH \\\\\n\\hline 2 & PERSISTENT VEGETATIVE STATE Patient exhibits no obvious cortical function. \\\\\n\\hline 3 & SEVERE DISABILITY (Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both. \\\\\n\\hline 4 & MODERATE DISABILITY (Disabled but independent). Patient is independent as far as daily life is concerned. The disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as intellectual and memory deficits and personality changes. \\\\\n\\hline 5 & \\begin{tabular}{l}\nGOOD RECOVERY \\\\\nResumption of normal activities even though there may be minor neurological or psychological deficits.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.9677734375,"confidence_rate":0.9999530003124448},{"cnt":[[517,827],[610,827],[610,1527],[517,1527]],"region":{"top_left_x":517,"top_left_y":827,"width":93,"height":700},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7bc63e1819064f21ba56361da15fe090","type":"table_column","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"","text_display":""},{"cnt":[[704,827],[1748,827],[1748,1527],[704,1527]],"region":{"top_left_x":704,"top_left_y":827,"width":1044,"height":700},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"39627fbeb5824b5f850abe6a6cacfa20","type":"table_column","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"","text_display":""},{"cnt":[[517,827],[1754,827],[1754,870],[517,870]],"region":{"top_left_x":517,"top_left_y":827,"width":1238,"height":43},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5571d8882c344918aded61aaa567d8e0","type":"table_row","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"","text_display":""},{"cnt":[[517,892],[1754,892],[1754,932],[517,932]],"region":{"top_left_x":517,"top_left_y":892,"width":1238,"height":40},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"58f0969fb354444a8a22daf9caa042fb","type":"table_row","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"","text_display":""},{"cnt":[[517,980],[1756,980],[1756,1056],[517,1056]],"region":{"top_left_x":517,"top_left_y":979,"width":1240,"height":77},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d905f6523a8040f7af669e79583f3f18","type":"table_row","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"","text_display":""},{"cnt":[[517,1095],[1753,1095],[1753,1207],[517,1207]],"region":{"top_left_x":517,"top_left_y":1095,"width":1236,"height":112},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d1eeea5f00e04f7393868afce4bfeb9a","type":"table_row","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"","text_display":""},{"cnt":[[517,1245],[1754,1245],[1754,1386],[517,1386]],"region":{"top_left_x":517,"top_left_y":1244,"width":1238,"height":142},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"91ad6d80f8c34bc6a9443277542b37b0","type":"table_row","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"","text_display":""},{"cnt":[[517,1425],[1754,1425],[1754,1525],[517,1525]],"region":{"top_left_x":517,"top_left_y":1425,"width":1238,"height":100},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bcc9b6e433a24890b36f1dad8c5fb816","type":"table_row","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"","text_display":""},{"cnt":[[524,830],[608,830],[608,863],[524,863]],"region":{"top_left_x":523,"top_left_y":830,"width":86,"height":34},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ae860f3003c443829d87cf50807c97a2","type":"simple_cell","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"Score","text_display":"Score","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[711,830],[873,830],[873,867],[711,867]],"region":{"top_left_x":711,"top_left_y":830,"width":162,"height":37},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"15658ed3723f4650a71ebf3db8b1e052","type":"simple_cell","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"Description","text_display":"Description","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[572,897],[593,897],[593,927],[572,927]],"region":{"top_left_x":572,"top_left_y":897,"width":21,"height":30},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b68af52c788a4332912af450150c5f5b","type":"simple_cell","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"1","text_display":"1","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[713,897],[807,897],[807,925],[713,925]],"region":{"top_left_x":712,"top_left_y":897,"width":96,"height":28},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"741af2af94d24385b831666799c91343","type":"simple_cell","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"DEATH","text_display":"DEATH","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[572,982],[596,982],[596,1016],[572,1016]],"region":{"top_left_x":572,"top_left_y":981,"width":25,"height":36},"line":20,"colu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DISABILITY (Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both.","text_display":"SEVERE DISABILITY (Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both.","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.998046875,"confidence_rate":0.999972847107038},{"cnt":[[713,1105],[969,1105],[969,1135],[713,1135]],"region":{"top_left_x":712,"top_left_y":1105,"width":258,"height":30},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"543d662c6d3649a8bc2291ca5b2a6af3","type":"text","conversion_output":false,"parent_id":"f185292534ba49f3897994ec2398144c","text":"SEVERE DISABILITY","text_display":"SEVERE DISABILITY","confidence":1,"confidence_rate":1},{"cnt":[[713,1133],[1739,1133],[1739,1169],[713,1169]],"region":{"top_left_x":712,"top_left_y":1132,"width":1028,"height":38},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0d280cfd0daf40a29710c27302a0ae62","type":"text","conversion_output":false,"parent_id":"f185292534ba49f3897994ec2398144c","text":"(Conscious but disabled). Patient depends upon others for daily support due to mental or physical","text_display":" (Conscious but disabled). Patient depends upon others for daily support due to mental or physical","confidence":1,"confidence_rate":1},{"cnt":[[713,1166],[900,1166],[900,1200],[713,1200]],"region":{"top_left_x":712,"top_left_y":1165,"width":189,"height":35},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9bd09e61d6e7403dae841219afbdba05","type":"text","conversion_output":false,"parent_id":"f185292534ba49f3897994ec2398144c","text":"disability or both.","text_display":" disability or both.","confidence":0.998046875,"confidence_rate":0.9999185435329331},{"cnt":[[572,1253],[596,1253],[596,1288],[572,1288]],"region":{"top_left_x":572,"top_left_y":1253,"width":25,"height":35},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"90345911adea4ac1b74d847fa48f9b67","type":"simple_cell","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","text":"4","text_display":"4","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[706,1250],[1648,1250],[1648,1382],[706,1382]],"region":{"top_left_x":706,"top_left_y":1249,"width":942,"height":134},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"943c26bd70044a0a969ec6f49a5c375e","type":"complex_cell","conversion_output":false,"parent_id":"1fc2f32df45249c797a83473beda8036","children_ids":["7ad4210d75304dbc82c03ab70e38ad56","e422575d8ad542c09d669c8e6e2f938e","f47174c3949c4978adb6c23d903805e8","7ac4eac22e4646d3ace708d9ed9b0714"],"text":"MODERATE DISABILITY (Disabled but independent). Patient is independent as far as daily life is concerned. The disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as intellectual and memory deficits and personality changes.","text_display":"MODERATE DISABILITY (Disabled but independent). Patient is independent as far as daily life is concerned. The disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as intellectual and memory deficits and personality changes.","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9677734375,"confidence_rate":0.9996469385860786},{"cnt":[[711,1255],[1017,1255],[1017,1284],[711,1284]],"region":{"top_left_x":711,"top_left_y":1254,"width":307,"height":31},"line":31,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7ad4210d75304dbc82c03ab70e38ad56","type":"text","conversion_output":false,"parent_id":"943c26bd70044a0a969ec6f49a5c375e","text":"MODERATE DISABILITY","text_display":"MODERATE DISABILITY","confidence":0.97900390625,"confidence_rate":0.9991162388130391},{"cnt":[[713,1284],[1641,1284],[1641,1317],[713,1317]],"region":{"top_left_x":712,"top_left_y":1284,"width":930,"height":33},"line":32,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e422575d8ad542c09d669c8e6e2f938e","type":"text","conversion_output":false,"parent_id":"943c26bd70044a0a969ec6f49a5c375e","text":"(Disabled but independent). Patient is independent as far as daily life is concerned. The","text_display":" (Disabled but independent). Patient is independent as far as daily life is concerned. The","confidence":1,"confidence_rate":1},{"cnt":[[713,1315],[1646,1315],[1646,1348],[713,1348]],"region":{"top_left_x":712,"top_left_y":1315,"width":935,"height":33},"line":33,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f47174c3949c4978adb6c23d903805e8","type":"text","conversion_output":false,"parent_id":"943c26bd70044a0a969ec6f49a5c375e","text":"disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as","text_display":" disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as","confidence":1,"confidence_rate":1},{"cnt":[[713,1344],[1316,1344],[1316,1379],[713,1379]],"region":{"top_left_x":712,"top_left_y":1344,"width":605,"height":35},"line":34,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7ac4eac22e4646d3ace708d9ed9b0714","type":"text","conversion_output":false,"parent_id":"943c26bd70044a0a969ec6f49a5c375e","text":"intellectual and memory deficits and 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Controlled Oral Word Association Test}","confidence":1,"confidence_rate":1},{"cnt":[[471,518],[1762,518],[1762,1974],[471,1974]],"region":{"top_left_x":470,"top_left_y":517,"width":1292,"height":1458},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"413b97b7deaf4e1e965db7b8f4a0c86d","type":"table","conversion_output":true,"children_ids":["e11e65af615a4197bc2c471732e5e166","53ae87b3f4144bbfbe97b936afb127d4","eb93d100381745b3a879f0b4441b6691","6c607b2716f24e7e8278dba4464b38da","376100486d014aa388af28c54c20fe7b","6e79022ad43746b28582e388f3492523","9d4f39abb1504eaab92b10f42da01573","f826cb4df8a74d76a10d744afcf2e1bd","9f5015aeff5b43d5bd0aecdc79b2c7e4","8818fd95482e4bbca087ab50bb398af5","9cc906b4bd1b486fa3a27201c30ba176","04a6fc561a324d10821a6fa3da53c390","7d2c4967933f42a392e621204f590e3d","37bf202fb4344917bae88f5479f0d254","ae513d53eb5e410a93f1db9e1d48771c","7c3edf1628bd46d7b1df8e5d5c6db186","41ce65a124a64c0b8136a6845c017c8f","56f566d2cf224b43b0883f23a1b3f42a","96ec700063e944dd989f7fd6092eb829","dce3f22896f7486e975492e7ab25cdef","02743a939b9643eeabb02241da81d65b","95bb38f3623240e4932fd0aaa6c350a2","d279c70abc07492abf6f8b70eaa86111","735ffcc417214aefb335d239329ebde1","d188b8c9cc624e5fb70492968556201a","0410616a5bf446e39e00f02d44f84917","450f20abbfc540608dfb2f3f940201d1","340c0ed61ac2490db8b741fd2789235a","504a7ba939e64b469540f3d403bf717a","72303b11253441239788033c7e3f788f","5b2aceabb5fa43eea34c488720256473","76e2cb9ac62f41e5b2efbb8829216c28","9b1d32c278b849129291d448ec4325a2","d1eefc32bda74ff89d13014c0620e803","6ba5f3fc55a946d5836df9e85a5d80c6","98b54170b29d40c49c0b70d78360499e","99860f09f1dc424aa3b5e88246e61bc5","0346d42040aa45e599f0faddb22d63b6","fbab71590f744f0f81e4895ad0b9da2a","83c043c671ca46279ff11d0fb6797ab3","be9d99ace4474c8a8e2b358def9b39f9","0ef08500632544568cfe582f3fe9a65d","f599f980f2404b43852dcbf471fb1a58","71efc575c52246efbcfcbcaae14c8a87","47c6de3a37454e7d8eb52c12ff85543d","1787576358bc4907bfa7ceb2dd41a0fd","234a363135904799be0fa62f3f32d16d","08682a1f5c9748f786f79b6976eaf202","41b238b7eb1e45fcbebb3403c6e44cea","975b1ea87ba540e6a8faea7ad5013414","9f04466fc57644f884660d3e61c8a980","6028f0afa63e4f39aa4b2ac920311d15","7d85e5b2709344c1be65abe5662067e0","cf29de6fa35b4a9989a77b2d9e490a70","184213e3a7374674889cead8db9a464c","d41a3178a5e6417a9ee9b61a82c441f5","8d504bf4ef8247fa98c5681a061cd893","544c691b505543dbbf3857551f308086","bdabcbd7422d4fcbb55029ac4139c490","d2c5cf70cc1447b5912a892e88e1a16f","6826b2cbf1114c98ab8b95e4c35aa20a","c8a2b632a6a8495b9d1ab15465b38a87","279b49324c3c42faba62e42b8183ef82","974aa30716d94cdfb481af3e29b06a30","12787fc30a664545ba25f3ad621d5160","891b33e1515441f1b68fd73ad4183081","8088053ae3a3419e810075a0ef01e563","a6323372eda4482ca3410c3d4a179845","59547b5f96b545208ae20001181f71d4","dacc1f23fade4b598b8b86250e617257","ab60bea66a084958a774411aeaa2b3cc","771280774c604111a6adf478c44b8e4d","3a9b858764634d6c853dc1e01995e8cd","0075f5437ed241ff87c2fdf69f0fcf6b","e7c62c88fc00491c8c51f02780120ab8","f9eeda2e4d464454bb01a83f7623e78d","d620ad5c62c04d039d39011d5a3a44a1","eac9ebb8f95d4a17ae9ccfbeb74741ed","c3fbf37d23804e9baf588164333c6202","4e152288dce641489e1d7f64e415fc7e","18366dff93114a44938916727960e7d3","bf31fcc19c564f33b6004cd886ee47a1","ca78d8d98f9942c9bf44191c71459cf7","4ad15f7db4044528827b3d3f345246e2","79d8d5760c4e4fa69d87b0a50e6e300a","cc1d309093ad40439c8c588e39295c8a","82ec945a9cdb4f479c673b0edefd37f1","3c7015a522de4653af7a12adf08fd391","a65aa7fb9703492e897ab410a391af2d","b74059cbd9af47c7b7c9748607255705","c06d662a09e04d16a86eeae059923ea2","aeb3e3e9939f4942abc2079f35349b86","250321003bf44938bf446d5127cb60f1","c0ea864f8b854168a4ad1fe8425c8fa1","749c26adcde94719ae7d985d47c0ddff","a17583d9b4e7477997a40bb0cb878351","e735a9ea60434c2c93d615c44721426a","da0476a9681a481fb34ddae31ce55c88","d8202a26e5cd4b54afeb6f12e6a83cdd","b84e795f86044b5494cdd7d0192b0582","945ea215c5a54751ad21473e53d0ac96","f690c0bfdf4a4c0f804fe4e58a2a642c","5997c15cba9b4c468cb50d450d8b2616","1a07d3de49b04f2fae04bdb6fd39df4c","039d7a2a2a9e4515a8c214a10f865721","45ec475dd72b48bf8030d29ff3f3d307","1c9e945f222e4f57b974257376b04b81","ae7f692f2dc649ebb49b2f271e86bf1d","50a19b1d94af40eaa47e9f8b73f3bb72","b6363a5e0a734b44975acdfc301f938a","26cfddfe3aa044bca237e0da8b0a8c57","67c45566ea574d8d8da88326b8ba997e","0097bb197fd54631b62fe2ae6fc8761d"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline \\multicolumn{4}{|c|}{Letter L} \\\\\n\\hline \\multicolumn{4}{|c|}{\\begin{tabular}{l}\nInstruct the study participant as follows: \\\\\n\"I am going to say a letter and I want you to name, as fast as you can, as many words as you can think of which start with this letter. The letter is \\(L\\). You will have one minute. Ready? Begin.\" \\\\\nRecord the study participant's responses in the following table.\n\\end{tabular}} \\\\\n\\hline & Acceptable & & Acceptable \\\\\n\\hline 1. & □ & 21. & □ \\\\\n\\hline 2. & □ & 22. & □ \\\\\n\\hline 3. & □ & 23. & □ \\\\\n\\hline 4. & □ & 24. & □ \\\\\n\\hline 5. & □ & 25. & □ \\\\\n\\hline 6. & □ & 26. & □ \\\\\n\\hline 7. & □ & 27. & □ \\\\\n\\hline 8. & □ & 28. & □ \\\\\n\\hline 9. & □ & 29. & □ \\\\\n\\hline 10. & □ & 30. & □ \\\\\n\\hline 11. & □ & 31. & □ \\\\\n\\hline 12. & □ & 32. & □ \\\\\n\\hline 13. & □ & 33. & □ \\\\\n\\hline 14. & □ & 34. & □ \\\\\n\\hline 15. & □ & 35. & □ \\\\\n\\hline 16. & □ & 36. & □ \\\\\n\\hline 17. & □ & 37. & □ \\\\\n\\hline 18. & □ & 38. & □ \\\\\n\\hline 19. & □ & 39. & □ \\\\\n\\hline 20. & □ & 40. & □ \\\\\n\\hline \\multicolumn{4}{|c|}{\\begin{tabular}{l}\nTotal words generated: □ \\\\\nTotal acceptable words: □\n\\end{tabular}} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|}\n\\hline \\multicolumn{4}{|c|}{Letter L} \\\\\n\\hline \\multicolumn{4}{|c|}{\\begin{tabular}{l}\nInstruct the study participant as follows: \\\\\n\"I am going to say a letter and I want you to name, as fast as you can, as many words as you can think of which start with this letter. The letter is \\(L\\). You will have one minute. Ready? Begin.\" \\\\\nRecord the study participant's responses in the following table.\n\\end{tabular}} \\\\\n\\hline & Acceptable & & Acceptable \\\\\n\\hline 1. & □ & 21. & □ \\\\\n\\hline 2. & □ & 22. & □ \\\\\n\\hline 3. & □ & 23. & □ \\\\\n\\hline 4. & □ & 24. & □ \\\\\n\\hline 5. & □ & 25. & □ \\\\\n\\hline 6. & □ & 26. & □ \\\\\n\\hline 7. & □ & 27. & □ \\\\\n\\hline 8. & □ & 28. & □ \\\\\n\\hline 9. & □ & 29. & □ \\\\\n\\hline 10. & □ & 30. & □ \\\\\n\\hline 11. & □ & 31. & □ \\\\\n\\hline 12. & □ & 32. & □ \\\\\n\\hline 13. & □ & 33. & □ \\\\\n\\hline 14. & □ & 34. & □ \\\\\n\\hline 15. & □ & 35. & □ \\\\\n\\hline 16. & □ & 36. & □ \\\\\n\\hline 17. & □ & 37. & □ \\\\\n\\hline 18. & □ & 38. & □ \\\\\n\\hline 19. & □ & 39. & □ \\\\\n\\hline 20. & □ & 40. & □ \\\\\n\\hline \\multicolumn{4}{|c|}{\\begin{tabular}{l}\nTotal words generated: □ \\\\\nTotal acceptable words: □\n\\end{tabular}} 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The letter is \\(L\\). You will have one minute. Ready? Begin.\" \\\\\nRecord the study participant's responses in the following table.\n\\end{tabular}","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":4},{"cnt":[[486,588],[1721,588],[1721,750],[486,750]],"region":{"top_left_x":486,"top_left_y":587,"width":1235,"height":164},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f5b89f58d5d44b0e8d03de18f212afce","type":"complex_cell","conversion_output":false,"parent_id":"72303b11253441239788033c7e3f788f","children_ids":["9c5df5f66c5c44b2b7bf5c68ccc2976a","5578242f96564883b2e8a5a5ade51266","4d12de3b784044bea69ac62e363eb605","61d5e0b977d9420d87054bf5fc894e1f"],"text":"\\begin{tabular}{l}\nInstruct the study participant as follows: \\\\\n\"I am going to say a letter and I want you to name, as fast as you can, as many words as you can think of which start with this letter. The letter is \\(L\\). You will have one minute. Ready? 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Credit only one item when people name the same animal at","confidence":0.9990234375,"confidence_rate":0.9999893800602199},{"cnt":[[460,967],[1137,967],[1137,1012],[460,1012]],"region":{"top_left_x":459,"top_left_y":966,"width":678,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc0e13303b8447d7a29f56314343cda2","type":"text","conversion_output":true,"text":"different developmental stages (e.g., sheep, lamb).","text_display":" different developmental stages (e.g., sheep, lamb).","confidence":1,"confidence_rate":1},{"cnt":[[460,1036],[1745,1036],[1745,1085],[460,1085]],"region":{"top_left_x":459,"top_left_y":1035,"width":1286,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff106a27fe424daaac20da63888d3f56","type":"text","conversion_output":true,"text":"Note: These minimalist initial instructions date back to an early research study on verbal fluency","text_display":"\n\nNote: These minimalist initial instructions date back to an early research study on verbal fluency","confidence":1,"confidence_rate":1},{"cnt":[[460,1076],[1697,1076],[1697,1121],[460,1121]],"region":{"top_left_x":459,"top_left_y":1076,"width":1239,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"728390db987348dcbf14fb91f5b31c96","type":"text","conversion_output":true,"text":"in aging and dementia by Wilma Rosen (1980) in which subjects were instructed to \"give the","text_display":" in aging and dementia by Wilma Rosen (1980) in which subjects were instructed to \"give the","confidence":1,"confidence_rate":1},{"cnt":[[460,1117],[1689,1117],[1689,1160],[460,1160]],"region":{"top_left_x":459,"top_left_y":1117,"width":1230,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4629dbfdd42c4882add6e9721bc2f126","type":"text","conversion_output":true,"text":"names of as many animals as you can think of' for 60 seconds. These very brief instructions","text_display":" names of as many animals as you can think of' for 60 seconds. These very brief instructions","confidence":0.6772291660308838,"confidence_rate":0.9960709152824441},{"cnt":[[460,1154],[1669,1154],[1669,1197],[460,1197]],"region":{"top_left_x":459,"top_left_y":1153,"width":1211,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b6d829f31ca464a82690a9b41d250c7","type":"text","conversion_output":true,"text":"have been subsequently used in several normative studies (e.g., Tombaugh et al., 1999 and","text_display":" have been subsequently used in several normative studies (e.g., Tombaugh et al., 1999 and","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[460,1190],[1674,1190],[1674,1233],[460,1233]],"region":{"top_left_x":459,"top_left_y":1190,"width":1215,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a480607903134eba920d02c47d4e75d8","type":"text","conversion_output":true,"text":"Mayo's MOANS studies such as Lucas et al., 1998) and in some other recent studies of the","text_display":" Mayo's MOANS studies such as Lucas et al., 1998) and in some other recent studies of the","confidence":0.9990236759185791,"confidence_rate":0.9999894968186404},{"cnt":[[460,1227],[1613,1227],[1613,1274],[460,1274]],"region":{"top_left_x":459,"top_left_y":1226,"width":1155,"height":49},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9686d64feca84c1c919a8f667a0a9a3f","type":"text","conversion_output":true,"text":"efficacy of verbal fluency as a diagnostic tool for dementia (e.g., Canning et al., 2004).","text_display":" efficacy of verbal fluency as a diagnostic tool for dementia (e.g., Canning et al., 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Inc.","text_display":"","confidence":0.991228092696872,"confidence_rate":0.9998644613867814},{"cnt":[[370,2608],[698,2608],[698,2649],[370,2649]],"region":{"top_left_x":369,"top_left_y":2608,"width":330,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52d30556e6eb4765b3e7f11a8b5f68a3","type":"page_info","conversion_output":false,"text":"534/aCSR 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(cont.)","confidence":1,"confidence_rate":1},{"cnt":[[700,357],[1540,357],[1540,415],[700,415]],"region":{"top_left_x":700,"top_left_y":356,"width":841,"height":59},"line":3,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"eda6751ea8df4dae902ee807532696a5","type":"text","conversion_output":true,"parent_id":"4ada763fd6de485ca32c00a3b96e5463","text":"Cognitive and Behavioral Assessments","text_display":" \\\\ Cognitive and Behavioral Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[587,483],[1661,483],[1661,548],[587,548]],"region":{"top_left_x":586,"top_left_y":483,"width":1075,"height":65},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b244330c1939407db4d88ade3f50ea08","type":"section_header","conversion_output":false,"children_ids":["258d4ef6261e49b5b71152d2557dc27c"],"text":"","text_display":""},{"cnt":[[591,490],[1656,490],[1656,544],[591,544]],"region":{"top_left_x":590,"top_left_y":489,"width":1067,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"258d4ef6261e49b5b71152d2557dc27c","type":"text","conversion_output":true,"parent_id":"b244330c1939407db4d88ade3f50ea08","text":"G. Boston Naming Test (BNT) 15-Item Short Form","text_display":"\n\n\\section*{G. Boston Naming Test (BNT) 15-Item Short Form}","confidence":0.998046875,"confidence_rate":0.9999616667183507},{"cnt":[[541,571],[1695,571],[1695,614],[541,614]],"region":{"top_left_x":541,"top_left_y":571,"width":1155,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8be6c3e43292418c8a67cd71330cb675","type":"text","conversion_output":true,"text":"The following error codes are used to categorize incorrect responses. The error code is to","text_display":"\n\nThe following error codes are used to categorize incorrect responses. The error code is to","confidence":1,"confidence_rate":1},{"cnt":[[546,606],[1121,606],[1121,642],[546,642]],"region":{"top_left_x":545,"top_left_y":605,"width":577,"height":38},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c552ec87e80543d79f02a307c0b388be","type":"text","conversion_output":true,"text":"be entered in the designated column below.","text_display":" be entered in the designated column 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ph & Nonword phonemically based paraphasia \\\\\n\\hline ph/v & (A phonemic paraphasia is scored if more than half of the target word phonology is preserved). \\\\\n\\hline v & Verbal paraphasia, semantically related to the target word \\\\\n\\hline v/u & Unrelated verbal paraphasia \\\\\n\\hline n & Neologism (less than 50\\% overlap with the phonology of the target word) \\\\\n\\hline mw & Multi-word paraphasic/paragrammatic error \\\\\n\\hline otu & Other off-target utterance (not considered paraphasia) \\\\\n\\hline cl & Circumlocution utterance (not considered paraphasia) \\\\\n\\hline p & Perseveration \\\\\n\\hline perc & Perceptual \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline ph & Nonword phonemically based paraphasia \\\\\n\\hline ph/v & (A phonemic paraphasia is scored if more than half of the target word phonology is preserved). \\\\\n\\hline v & Verbal paraphasia, semantically related to the target word \\\\\n\\hline v/u & Unrelated verbal paraphasia \\\\\n\\hline n & Neologism (less than 50\\% overlap with the phonology of the target word) \\\\\n\\hline mw & Multi-word paraphasic/paragrammatic error \\\\\n\\hline otu & Other off-target utterance (not considered paraphasia) \\\\\n\\hline cl & Circumlocution utterance (not considered paraphasia) \\\\\n\\hline p & Perseveration \\\\\n\\hline perc & Perceptual 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Item Response & Correct Response & Latency Seconds & Stimulus Cue & Phonemic Cue & Error Code(s) & Multiple Choice \\\\\n\\hline 1. house (home) (a kind of building) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 2. comb . . . . . . . . . . . (used for fixing hair) & & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & & \\\\\n\\hline 3. toothbrush. (used in the mouth) & & & - & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & - \\\\\n\\hline 4. estopus. (an ocean animal) & & & - & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & - \\\\\n\\hline 5. bench. . . . . . . . . . . . (used for sitting) & & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 6. yolcano. (a kind of mountain) & & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 7. canoe (used in the water) & & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline \\multicolumn{2}{|c|}{\\multirow{2}{*}{(an animal)}} & \\multirow[b]{2}{*}{\\begin{tabular}{l}\n(2) \\\\\n(2)\n\\end{tabular}} & & - & \\multirow{2}{*}{-} & \\(\\_\\_\\_\\_\\) \\\\\n\\hline \\multicolumn{7}{|c|}{} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|l|}\n\\hline Item Response & Correct Response & Latency Seconds & Stimulus Cue & Phonemic Cue & Error Code(s) & Multiple Choice \\\\\n\\hline 1. house (home) (a kind of building) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 2. comb . . . . . . . . . . . (used for fixing hair) & & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & & \\\\\n\\hline 3. toothbrush. 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The course is marked with tape at 0 meters, 2","text_display":" surface measuring a length of 14 meters. The course is marked with tape at 0 meters, 2","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[434,1296],[1710,1296],[1710,1334],[434,1334]],"region":{"top_left_x":433,"top_left_y":1295,"width":1278,"height":40},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fc5b3f00d7a4a26855b3b7fcff91469","type":"text","conversion_output":true,"text":"meters, 12 meters, and 14 meters. 2 chairs can be placed near the 0 meter and 14","text_display":" meters, 12 meters, and 14 meters. 2 chairs can be placed near the 0 meter and 14","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[434,1336],[621,1336],[621,1369],[434,1369]],"region":{"top_left_x":433,"top_left_y":1336,"width":188,"height":33},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71f0ea5f0c334f7abf22f91a9e73b515","type":"text","conversion_output":true,"text":"meter mark.","text_display":" meter mark.","confidence":1,"confidence_rate":1},{"cnt":[[713,1414],[1528,1414],[1528,1562],[713,1562]],"region":{"top_left_x":713,"top_left_y":1413,"width":815,"height":149},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9c41ab621954387811514c2f3d0aaae","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-202.jpg?height=149&width=815&top_left_y=1413&top_left_x=713)"},{"cnt":[[432,1607],[1783,1607],[1783,1648],[432,1648]],"region":{"top_left_x":431,"top_left_y":1607,"width":1353,"height":41},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f54d29f3e994042bce4205b38f6bd79","type":"text","conversion_output":true,"text":"3. Instruct the subject in the goal of the 10 meter walk test while the subject is seated:","text_display":"\n3. Instruct the subject in the goal of the 10 meter walk test while the subject is seated:","confidence":1,"confidence_rate":1},{"cnt":[[501,1667],[1807,1667],[1807,1708],[501,1708]],"region":{"top_left_x":500,"top_left_y":1667,"width":1307,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58a2b0167fe8471093b8c46e79ba5e70","type":"text","conversion_output":true,"text":"\"You are going to walk a distance of about 40 feet. We will repeat this distance","text_display":"\n\"You are going to walk a distance of about 40 feet. We will repeat this distance","confidence":0.76318359375,"confidence_rate":0.9969336126380315},{"cnt":[[498,1712],[1751,1712],[1751,1755],[498,1755]],"region":{"top_left_x":498,"top_left_y":1712,"width":1253,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae86a7a6e33a411ea1be8ce09bfba279","type":"text","conversion_output":true,"text":"four times. The first two times will be completed at your comfortable pace,","text_display":" four times. The first two times will be completed at your comfortable pace,","confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[498,1757],[1717,1757],[1717,1798],[498,1798]],"region":{"top_left_x":498,"top_left_y":1757,"width":1219,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd8e934104dd4a28b739ad3b61c63f39","type":"text","conversion_output":true,"text":"the final two times you will walk as quickly and safely as you can. Do you","text_display":" the final two times you will walk as quickly and safely as you can. Do you","confidence":1,"confidence_rate":1},{"cnt":[[503,1800],[866,1800],[866,1841],[503,1841]],"region":{"top_left_x":502,"top_left_y":1800,"width":364,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"097a9410a1284595aa4a6264cbd41044","type":"text","conversion_output":true,"text":"have any questions?\"","text_display":" have any questions?\"","confidence":1,"confidence_rate":1},{"cnt":[[430,1861],[1265,1861],[1265,1901],[430,1901]],"region":{"top_left_x":429,"top_left_y":1860,"width":837,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5082d9e742434a8fb1e23bb7188341c9","type":"text","conversion_output":true,"text":"4. Demonstrate where you want the subject to walk.","text_display":"\n4. Demonstrate where you want the subject to walk.","confidence":1,"confidence_rate":1},{"cnt":[[434,1921],[1760,1921],[1760,1962],[434,1962]],"region":{"top_left_x":433,"top_left_y":1920,"width":1327,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2efb955b17794d9785bb804982f6eea4","type":"text","conversion_output":true,"text":"5. Walk the subject to the start line (0 meters). Provide the subject with the following","text_display":"\n5. Walk the subject to the start line (0 meters). 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The start command is \"Ready and Go\".","text_display":" the floor.) The start command is \"Ready and Go\".","confidence":1,"confidence_rate":1},{"cnt":[[434,2131],[1798,2131],[1798,2172],[434,2172]],"region":{"top_left_x":433,"top_left_y":2131,"width":1366,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4009d3f25704a539439edf50f73f80c","type":"text","conversion_output":true,"text":"6. When you and the subject are ready, say \"Ready and Go\". If the subject starts too","text_display":"\n6. When you and the subject are ready, say \"Ready and Go\". 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Instructions for Recording Time:","text_display":"\n7. Instructions for Recording Time:","confidence":1,"confidence_rate":1},{"cnt":[[490,533],[1732,533],[1732,574],[490,574]],"region":{"top_left_x":489,"top_left_y":532,"width":1243,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28024f01a8834b26a17a3319473215bc","type":"text","conversion_output":true,"text":"□ START the stopwatch when the subject's first foot crosses the plane of the 2","text_display":"\n□ START the stopwatch when the subject's first foot crosses the plane of the 2","confidence":0.989750862121582,"confidence_rate":0.9998743734776916},{"cnt":[[546,576],[707,576],[707,608],[546,608]],"region":{"top_left_x":545,"top_left_y":575,"width":162,"height":34},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb80f14962904863b67592ffc66e8ec2","type":"text","conversion_output":true,"text":"meter line","text_display":" meter line","confidence":1,"confidence_rate":1},{"cnt":[[490,636],[1729,636],[1729,677],[490,677]],"region":{"top_left_x":489,"top_left_y":635,"width":1241,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eab6b834698f4fcbb2e5613b11f1a2f2","type":"text","conversion_output":true,"text":"□ STOP the stopwatch when the subject's first foot crosses the plane of the 12","text_display":"\n□ STOP the stopwatch when the subject's first foot crosses the plane of the 12","confidence":0.9946367697565393,"confidence_rate":0.9999344208821898},{"cnt":[[546,681],[711,681],[711,715],[546,715]],"region":{"top_left_x":545,"top_left_y":681,"width":167,"height":35},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39cff38a0b7343e18538f613523045f3","type":"text","conversion_output":true,"text":"meter line.","text_display":" meter line.","confidence":1,"confidence_rate":1},{"cnt":[[490,739],[1729,739],[1729,780],[490,780]],"region":{"top_left_x":489,"top_left_y":739,"width":1241,"height":41},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"189e2ff4b89948daa67e80b89aae71b5","type":"text","conversion_output":true,"text":"□ Have the subject continue walking until he/she reaches the chair after the 14","text_display":"\n□ Have the subject continue walking until he/she reaches the chair after the 14","confidence":0.99755859375,"confidence_rate":0.999970549935568},{"cnt":[[546,786],[711,786],[711,819],[546,819]],"region":{"top_left_x":545,"top_left_y":786,"width":167,"height":33},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d69164f847a549fe8141d6c710802f88","type":"text","conversion_output":true,"text":"meter line.","text_display":" meter line.","confidence":1,"confidence_rate":1},{"cnt":[[490,844],[1785,844],[1785,887],[490,887]],"region":{"top_left_x":489,"top_left_y":844,"width":1297,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fced829175264f68895d6a31561770bc","type":"text","conversion_output":true,"text":"□ Record (in seconds to the hundredths) the time it took for the subject to walk the","text_display":"\n□ Record (in seconds to the hundredths) the time it took for the subject to walk the","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[546,889],[838,889],[838,926],[546,926]],"region":{"top_left_x":545,"top_left_y":889,"width":293,"height":37},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f40012903c546e68a4f93c3d1bc2442","type":"text","conversion_output":true,"text":"ten meter distance","text_display":" ten meter distance","confidence":1,"confidence_rate":1},{"cnt":[[546,950],[1738,950],[1738,986],[546,986]],"region":{"top_left_x":545,"top_left_y":949,"width":1194,"height":38},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31c1f8b9e9044bbf88c28360c72ebc89","type":"text","conversion_output":true,"text":"\"Comfortable\" Pace Trial 1 line on the 10 Meter Walk Test Source Document.","text_display":"\n\"Comfortable\" Pace Trial 1 line on the 10 Meter Walk Test Source Document.","confidence":1,"confidence_rate":1},{"cnt":[[490,1010],[1575,1010],[1575,1051],[490,1051]],"region":{"top_left_x":489,"top_left_y":1009,"width":1086,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6daad98b9cfc4423a7becfa64d45da01","type":"text","conversion_output":true,"text":"□ The subject can rest, if needed, in the chair near the 14 meter line.","text_display":"\n□ The subject can rest, if needed, in the chair near the 14 meter line.","confidence":0.9970703125,"confidence_rate":0.9999628616081941},{"cnt":[[432,1087],[1785,1087],[1785,1132],[432,1132]],"region":{"top_left_x":431,"top_left_y":1087,"width":1355,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae7a9d938f7e41c69232094ef694124e","type":"text","conversion_output":true,"text":"8. When the subject is ready, have them repeat the SAME PROCEDURE except they","text_display":"\n8. 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When you and the subject are ready, say \"Ready and Go\". If the subject starts too","text_display":"\n11. When you and the subject are ready, say \"Ready and Go\". If the subject starts too","confidence":1,"confidence_rate":1},{"cnt":[[501,2196],[943,2196],[943,2241],[501,2241]],"region":{"top_left_x":500,"top_left_y":2195,"width":444,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9fc7f40728d5468bb60dc50c4f3d981f","type":"text","conversion_output":true,"text":"early, have them start again.","text_display":" early, have them start again.","confidence":1,"confidence_rate":1},{"cnt":[[432,2423],[844,2423],[844,2460],[432,2460]],"region":{"top_left_x":431,"top_left_y":2423,"width":414,"height":37},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bbdcd0ccc3f4d48ba88de53998a2be9","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9892966209690712,"confidence_rate":0.9996413619181371},{"cnt":[[434,2462],[844,2462],[844,2494],[434,2494]],"region":{"top_left_x":433,"top_left_y":2462,"width":412,"height":33},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2b41853e8f846769b4d59972c9e78b5","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1749,2462],[1809,2462],[1809,2496],[1749,2496]],"region":{"top_left_x":1748,"top_left_y":2462,"width":61,"height":35},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3feb7d13d6a42d0a09407d0407d20a0","type":"page_info","conversion_output":false,"text":"107","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[372,2574],[1416,2574],[1416,2615],[372,2615]],"region":{"top_left_x":371,"top_left_y":2573,"width":1045,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"133b32c556e14fe08e11ef617962094e","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9917242183795405,"confidence_rate":0.9998721586952609},{"cnt":[[374,2608],[690,2608],[690,2645],[374,2645]],"region":{"top_left_x":373,"top_left_y":2608,"width":317,"height":37},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08a722afb7aa4275809455a6b5a1429f","type":"page_info","conversion_output":false,"text":"539/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-204","page":204,"lines":[{"cnt":[[904,314],[1332,314],[1332,408],[904,408]],"region":{"top_left_x":904,"top_left_y":313,"width":429,"height":96},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6128761d98e4522996e80bdf44a3a67","type":"section_header","conversion_output":false,"children_ids":["5bd2beef2af840dd8b96ddeed8ac7523","cbad0883c6b248cf986b3cecc9b45afa"],"text":"","text_display":""},{"cnt":[[907,318],[1326,318],[1326,367],[907,367]],"region":{"top_left_x":906,"top_left_y":317,"width":420,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bd2beef2af840dd8b96ddeed8ac7523","type":"text","conversion_output":true,"parent_id":"f6128761d98e4522996e80bdf44a3a67","text":"Appendix 12 (cont.)","text_display":"\n\n\\section*{Appendix 12 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[917,363],[1326,363],[1326,402],[917,402]],"region":{"top_left_x":917,"top_left_y":363,"width":409,"height":39},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbad0883c6b248cf986b3cecc9b45afa","type":"text","conversion_output":true,"parent_id":"f6128761d98e4522996e80bdf44a3a67","text":"10 Meter Walk Test","text_display":" 10 Meter Walk Test}","confidence":0.99951171875,"confidence_rate":0.9999778002237774},{"cnt":[[434,471],[999,471],[999,513],[434,513]],"region":{"top_left_x":433,"top_left_y":470,"width":567,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3cb84b61bb594714b33f8823dfb14bb5","type":"text","conversion_output":true,"text":"12. Instructions for Recording Time:","text_display":"\n12. Instructions for Recording Time:","confidence":1,"confidence_rate":1},{"cnt":[[490,533],[1732,533],[1732,574],[490,574]],"region":{"top_left_x":489,"top_left_y":532,"width":1243,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f0341021b3f4dc4b10f61ba6a86be85","type":"text","conversion_output":true,"text":"□ START the stopwatch when the subject's first foot crosses the plane of the 2","text_display":"\n□ START the stopwatch when the subject's first foot crosses the plane of the 2","confidence":0.9921944125089794,"confidence_rate":0.9999044410227925},{"cnt":[[546,576],[707,576],[707,610],[546,610]],"region":{"top_left_x":545,"top_left_y":575,"width":162,"height":36},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a00b3b47e974a3fb70bbeb223120b3e","type":"text","conversion_output":true,"text":"meter line","text_display":" meter line","confidence":1,"confidence_rate":1},{"cnt":[[490,636],[1729,636],[1729,677],[490,677]],"region":{"top_left_x":489,"top_left_y":635,"width":1241,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00556990f57d47e9935f66ab2943e7f8","type":"text","conversion_output":true,"text":"□ STOP the stopwatch when the subject's first foot crosses the plane of the 12","text_display":"\n□ STOP the stopwatch when the subject's first foot crosses the plane of the 12","confidence":0.9946367697565393,"confidence_rate":0.9999344208821898},{"cnt":[[546,681],[711,681],[711,715],[546,715]],"region":{"top_left_x":545,"top_left_y":681,"width":167,"height":35},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bd92afcc27741649b529fde78dc29e4","type":"text","conversion_output":true,"text":"meter line.","text_display":" meter line.","confidence":1,"confidence_rate":1},{"cnt":[[490,739],[1729,739],[1729,780],[490,780]],"region":{"top_left_x":489,"top_left_y":739,"width":1241,"height":41},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11a9a4c789da432e96bc09d9abd84c16","type":"text","conversion_output":true,"text":"□ Have the subject continue walking until he/she reaches the chair after the 14","text_display":"\n□ Have the subject continue walking until he/she reaches the chair after the 14","confidence":0.99755859375,"confidence_rate":0.999970549935568},{"cnt":[[546,786],[711,786],[711,819],[546,819]],"region":{"top_left_x":545,"top_left_y":786,"width":167,"height":33},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d116543f086242b99b418515655e5bcd","type":"text","conversion_output":true,"text":"meter line.","text_display":" meter line.","confidence":1,"confidence_rate":1},{"cnt":[[490,844],[1790,844],[1790,887],[490,887]],"region":{"top_left_x":489,"top_left_y":844,"width":1301,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b0067be429f48b4b7d1bb594813cec8","type":"text","conversion_output":true,"text":"□ Record (in seconds to the hundredths) the time it took for the subject to walk the","text_display":"\n□ Record (in seconds to the hundredths) the time it took for the subject to walk the","confidence":0.98095703125,"confidence_rate":0.9997839938793736},{"cnt":[[546,889],[1807,889],[1807,926],[546,926]],"region":{"top_left_x":545,"top_left_y":889,"width":1262,"height":37},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c65a75518f646ca800d141867f5b6d2","type":"text","conversion_output":true,"text":"ten meter distance on the \"As Fast As Possible\" Pace Trial 1 line on the 10 Meter","text_display":" ten meter distance on the \"As Fast As Possible\" Pace Trial 1 line on the 10 Meter","confidence":1,"confidence_rate":1},{"cnt":[[546,932],[1003,932],[1003,969],[546,969]],"region":{"top_left_x":545,"top_left_y":932,"width":459,"height":37},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee470455d14d4b1d8e3619e14f9fa8d1","type":"text","conversion_output":true,"text":"Walk Test Source Document.","text_display":" Walk Test Source Document.","confidence":1,"confidence_rate":1},{"cnt":[[490,993],[1575,993],[1575,1033],[490,1033]],"region":{"top_left_x":489,"top_left_y":992,"width":1086,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c25b670d1f7c419f821f99995a7a7bba","type":"text","conversion_output":true,"text":"□ The subject can rest, if needed, in the chair near the 14 meter line.","text_display":"\n□ The subject can rest, if needed, in the chair near the 14 meter line.","confidence":0.99658203125,"confidence_rate":0.9999566614030738},{"cnt":[[434,1074],[1785,1074],[1785,1115],[434,1115]],"region":{"top_left_x":433,"top_left_y":1074,"width":1353,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41f8d35d24964d10ac039f6ddd97fe9e","type":"text","conversion_output":true,"text":"13. When the subject is ready, have them repeat the SAME PROCEDURE except they","text_display":"\n13. 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hemorrhage","confidence":0.9755859375,"confidence_rate":0.9993822652029788},{"cnt":[[425,2419],[849,2419],[849,2462],[425,2462]],"region":{"top_left_x":425,"top_left_y":2419,"width":424,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f169af45bd524525ad00d98d288a1f78","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9975595474243164,"confidence_rate":0.9999185554723219},{"cnt":[[430,2458],[849,2458],[849,2499],[430,2499]],"region":{"top_left_x":429,"top_left_y":2457,"width":420,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec57a1cf882747b8845ceee6e196dfcb","type":"page_info","conversion_output":false,"text":"Protocol ML29093, Version 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\\multicolumn{5}{|c|}{HEMATOLOGY} \\\\\n\\hline ITEM & Grade 1 Toxicity & Grade 2 Toxicity & Grade 3 Toxicity & Grade 4 Toxicity \\\\\n\\hline Hemoglobin & \\(9.5-10.5 gm / Dl\\) & \\(8.0-9.4 gm / Dl\\) & \\(6.5-7.9 gm / Dl\\) & \\(<6.5 gm / Dl\\) \\\\\n\\hline Absolute Neutrophil Count & \\(1000-1500 / mm ^{3}\\) & \\(750-999 / mm ^{3}\\) & \\(500-749 / mm ^{3}\\) & \\(<500 / mm ^{3}\\) \\\\\n\\hline Platelets & \\(75000-99000 / mm ^{3}\\) & \\(50000-74999 / mm ^{3}\\) & \\(20000-49000 / mm ^{3}\\) & \\(<20000 / mm ^{3}\\) \\\\\n\\hline Prothrombin Time (PT) & \\(1.01-1.25 \\times\\) ULN & \\(1.26-1.5 \\times\\) ULN & 1.51-3.0x ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Activated Partial Thromboplastin (APPT) & 1.01-1.66x ULN & \\(1.67-2.33 \\times\\) ULN & 2.34-3x ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Fibrinogen & 0.75-0.99 X LLN & 0.50-0.74× LL.N & 0.25-0.49 x LLN & \\(<0.25 \\times\\) LLN \\\\\n\\hline Fibrim Split Product & \\(20-40 mcg / ml\\) & \\(41-50 mcg / ml\\) & \\(51-60 mcg / ml\\) & \\(>60 mcg / ml\\) \\\\\n\\hline Methemoglobin & 5-9.9\\% & \\(10.0-14.9 \\%\\) & 15.0-19.9\\% & \\(>20 \\%\\) \\\\\n\\hline \\multicolumn{5}{|c|}{LIVER ENZYMES} \\\\\n\\hline AST (SGOT) & \\(1.25-2.5 \\times\\) ULN & 2.6-5 x ULN & 5.1-10x ULN & \\(>10 x\\) ULN \\\\\n\\hline ALT (SGPT) & \\(1.25-2.5 \\times\\) ULN & \\(2.6-5 x\\) ULN & 5.1-10 × ULN & \\(>10 \\times\\) ULN \\\\\n\\hline GGT & \\(1.25-2.5 \\times\\) ULN & \\(1.6-5 x\\) ULN & \\(5.1-10 x\\) ULN & \\(>10 \\times\\) ULN \\\\\n\\hline Alkaline Phosphatase & 125-2.5x ULN & 1.6-5 x ULN & \\(5.1-10 x\\) ULN & \\(>10 x\\) ULN \\\\\n\\hline Amylase & 1.1-1.5x ULN & \\(1.6-2.0 \\times\\) ULN & 2.1-5.0x ULN & \\(>5.1 \\times ULN\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multicolumn{5}{|c|}{HEMATOLOGY} \\\\\n\\hline ITEM & Grade 1 Toxicity & Grade 2 Toxicity & Grade 3 Toxicity & Grade 4 Toxicity \\\\\n\\hline Hemoglobin & \\(9.5-10.5 gm / Dl\\) & \\(8.0-9.4 gm / 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\\multicolumn{5}{|l|}{CHEMISTRIES (continued)} \\\\\n\\hline Hyperglycemis (note if fasting) & \\(116-160 mg / dL\\) & \\(161-250 mg / dL\\) & \\(251.500 mg / dL\\) & \\(>500 mg / dL\\). or ketoacidosis or seizures \\\\\n\\hline Hypocalcemia (corrected for albumin) & \\(8.4-7.8 mg / dL\\) & \\(7.7-7.0 mg / dL\\). & \\(69-6.1 mg / dL\\) & \\(<6.1 mg / dL\\) or life threatening arrhythmia or tetany \\\\\n\\hline Hypercalcemia (correct for albumin) & \\(10.6-11.5 mg / dL\\) & \\(11.6-12.5 mg / dL\\) & \\(12.6-13.5 mg / dL\\) & \\(>13.5 mg / dL\\) life-threatening arrhythmia \\\\\n\\hline Hypomagnesemia & \\(1.4-1.2 mEq / L\\) & \\(1.1-0.9 mEq / L\\) & \\(0.8-0.6 mEq / L\\) & \\(<0.6 mEq / L\\) or lifethreatening arrhythmia \\\\\n\\hline Hypophosphatemia & \\(2.0-2.4 mg / dL\\) & \\(1.5-1.9 mg / dL\\) or replacement Rx required & \\(10-1.4 mg / dL\\) mtensive Rx or hospitalization required & \\(<1.0 mg / dL\\) or lifethreatening arrhythmia \\\\\n\\hline Hyperbilirubinemia & \\(1.1-1.5 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Rx required & requires acute Rx; No hospitalization & requires hospitalization \\\\\n\\hline Hypotension & transient orthostatic hypotension, No Rx & symptoms correctable with oral fluids Rx & requires IV fluids, no hospitalization required & requires hospitalization \\\\\n\\hline Pericarditis & minimal effusion & mild/moderate asymptomatic effusion, no Rx & symptomatic effusion; pain; EKG changes & tamponade; pericardiocentesis or surgery required \\\\\n\\hline Hemorrhage, Blood Loss & microscopic/occult & mild, no transfusion & gross blood loss; 1-2 units transfused & massive blood loss; \\(>3\\) units transfused \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multicolumn{5}{|l|}{CHEMISTRIES (continued)} \\\\\n\\hline Hyperglycemis (note if fasting) & \\(116-160 mg / dL\\) & \\(161-250 mg / dL\\) & \\(251.500 mg / dL\\) & \\(>500 mg / dL\\). or ketoacidosis or seizures \\\\\n\\hline Hypocalcemia (corrected for albumin) & \\(8.4-7.8 mg / dL\\) & \\(7.7-7.0 mg / dL\\). & \\(69-6.1 mg / dL\\) & \\(<6.1 mg / dL\\) or life threatening arrhythmia or tetany \\\\\n\\hline Hypercalcemia (correct for albumin) & \\(10.6-11.5 mg / dL\\) & \\(11.6-12.5 mg / dL\\) & \\(12.6-13.5 mg / dL\\) & \\(>13.5 mg / dL\\) life-threatening arrhythmia \\\\\n\\hline Hypomagnesemia & \\(1.4-1.2 mEq / L\\) & \\(1.1-0.9 mEq / L\\) & \\(0.8-0.6 mEq / L\\) & \\(<0.6 mEq / L\\) or lifethreatening arrhythmia \\\\\n\\hline Hypophosphatemia & \\(2.0-2.4 mg / dL\\) & \\(1.5-1.9 mg / dL\\) or replacement Rx required & \\(10-1.4 mg / dL\\) mtensive Rx or hospitalization required & \\(<1.0 mg / dL\\) or lifethreatening arrhythmia \\\\\n\\hline Hyperbilirubinemia & \\(1.1-1.5 \\times\\) ULN & 1.6-2.5 × ULN & \\(2.6-5 x\\) ULN & > 5xULN \\\\\n\\hline BUN & \\(1.25-2.5 \\times\\) ULN & 2.6-5 x ULN & 5.1-10x ULN & > 10 xULN \\\\\n\\hline Creatinine & \\(1.1 \\times 1.5 \\times ULN\\) & 1.6-3.0x ULN & 3.1-6x ULN & >6x ULN or required dialysis \\\\\n\\hline \\multicolumn{5}{|c|}{URINALYSIS} \\\\\n\\hline Proteinuria & 1+ or \\(<0.3 \\%\\) or \\(<3 g / L\\) or \\(200 mg -1 gm\\) loss/day & 2-3+or 0.3-1.0\\% or \\(3-10 g / L\\) 1.2 gm loss/day & 4+ or \\(>1.0 \\%\\) or \\(>10\\) g/L. \\(2-3.5 gm\\) loss/day & nephrotic syndrome or \\(\\gg 3,5 gm\\) loss/day \\\\\n\\hline Hematuria & microscopic only & gross, no clots & gross* clots & obstructive or required transfusion \\\\\n\\hline \\multicolumn{5}{|l|}{CARDIAC DYSFUNCTION} \\\\\n\\hline Cardiac Rhythm & & asymptomatic, transient signs, no Rx required & recurrent/persistent; No Rx required & requires treatment \\\\\n\\hline Hypertension & transient inc. \\(>20 mm\\); no Rx & recurrent, chronic, > 20 mm . 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Nearly 800,000 strokes occur in the U.S. annually; of these,","text_display":" States (U.S.). Nearly 800,000 strokes occur in the U.S. annually; of these,","confidence":0.9639346355106682,"confidence_rate":0.9995409579900708},{"cnt":[[460,604],[1738,604],[1738,647],[460,647]],"region":{"top_left_x":459,"top_left_y":603,"width":1280,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b627db43fa6843f9b4888c658bf96ac4","type":"text","conversion_output":true,"text":"approximately \\(85 \\%\\) are ischemic in nature (Rosamond et al. 2007). Treatment options","text_display":" approximately \\(85 \\%\\) are ischemic in nature (Rosamond et al. 2007). Treatment options","confidence":0.9614624977111816,"confidence_rate":0.999563431783043},{"cnt":[[460,649],[1717,649],[1717,694],[460,694]],"region":{"top_left_x":459,"top_left_y":648,"width":1258,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b58c0d975d754cf789de2a1a16b7c996","type":"text","conversion_output":true,"text":"are limited, as the only approved therapy for acute ischemic stroke (AIS) is alteplase,","text_display":" are limited, as the only approved therapy for acute ischemic stroke (AIS) is alteplase,","confidence":1,"confidence_rate":1},{"cnt":[[458,696],[1772,696],[1772,737],[458,737]],"region":{"top_left_x":457,"top_left_y":696,"width":1316,"height":41},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0303c7308cda4b69a85da21884186f5f","type":"text","conversion_output":true,"text":"which is to be used in eligible patients and started within 3 hours from the onset of stroke","text_display":" which is to be used in eligible patients and started within 3 hours from the onset of stroke","confidence":1,"confidence_rate":1},{"cnt":[[460,741],[1764,741],[1764,784],[460,784]],"region":{"top_left_x":459,"top_left_y":741,"width":1305,"height":44},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6a64b6cd9bd492bbc33bafeab1c3c2b","type":"text","conversion_output":true,"text":"symptoms. Stroke with \"only minor or rapidly improving stroke symptoms\" is considered","text_display":" symptoms. 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Consistent with this","text_display":" excluded from definitive trials to date (Jauch et al. 2013). 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In a national registry, among 93,517 cases arriving to Emergency","text_display":" et al. 2012). In a national registry, among 93,517 cases arriving to Emergency","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[460,1233],[1648,1233],[1648,1276],[460,1276]],"region":{"top_left_x":459,"top_left_y":1233,"width":1189,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"143be09558c348e3b5831ca5dd7d48df","type":"text","conversion_output":true,"text":"Departments within 2 hours, \\(29,200(31 \\%)\\) were not treated solely due to mild or","text_display":" Departments within 2 hours, \\(29,200(31 \\%)\\) were not treated solely due to mild or","confidence":0.9517064094543457,"confidence_rate":0.9994439896290179},{"cnt":[[460,1278],[1751,1278],[1751,1321],[460,1321]],"region":{"top_left_x":459,"top_left_y":1278,"width":1292,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebc9c2675ccc41008dac8911f9e36912","type":"text","conversion_output":true,"text":"improving symptoms, and \\(80.1 \\%\\) of untreated cases had a National Institutes of Health","text_display":" improving symptoms, and \\(80.1 \\%\\) of untreated cases had a National Institutes of Health","confidence":0.99755859375,"confidence_rate":0.999973430881859},{"cnt":[[460,1323],[1222,1323],[1222,1369],[460,1369]],"region":{"top_left_x":459,"top_left_y":1323,"width":764,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d04ed2e36cfe4b8393a1c135cc1851d8","type":"text","conversion_output":true,"text":"Stroke Scale (NIHSS) score \\(\\leq 5\\) (Smith et al. 2011).","text_display":" Stroke Scale (NIHSS) score \\(\\leq 5\\) (Smith et al. 2011).","confidence":0.994140625,"confidence_rate":0.9998986842967655},{"cnt":[[455,1405],[1678,1405],[1678,1450],[455,1450]],"region":{"top_left_x":455,"top_left_y":1405,"width":1223,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32f4c69fb9914dbda86e3f4f15b67106","type":"text","conversion_output":true,"text":"While treatment of mild stroke is generally uncommon, leading stroke centers vary","text_display":"\n\nWhile treatment of mild stroke is generally uncommon, leading stroke centers vary","confidence":1,"confidence_rate":1},{"cnt":[[455,1452],[1785,1452],[1785,1497],[455,1497]],"region":{"top_left_x":455,"top_left_y":1452,"width":1331,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db6277daec8944f38eebbcade165e46c","type":"text","conversion_output":true,"text":"widely in their approach. For example, the proportion of mild stroke patients (NIHSS \\(\\leq 3\\) )","text_display":" widely in their approach. 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There is unquestionable community","text_display":"\npersonal communication). There is unquestionable community","confidence":1,"confidence_rate":1},{"cnt":[[460,1818],[1497,1818],[1497,1858],[460,1858]],"region":{"top_left_x":459,"top_left_y":1817,"width":1039,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7513c1e335c24e41833761d4af09895b","type":"text","conversion_output":true,"text":"equipoise regarding the acute treatment of the mild stroke population.","text_display":" equipoise regarding the acute treatment of the mild stroke population.","confidence":1,"confidence_rate":1},{"cnt":[[455,1886],[1240,1886],[1240,1936],[455,1936]],"region":{"top_left_x":455,"top_left_y":1886,"width":785,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"659ff849d6c444b1b6d65a3c01c0f55f","type":"section_header","conversion_output":false,"children_ids":["de38d36ca1bf42a184a73e9fbb5490f0"],"text":"","text_display":""},{"cnt":[[460,1891],[1235,1891],[1235,1931],[460,1931]],"region":{"top_left_x":459,"top_left_y":1890,"width":777,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de38d36ca1bf42a184a73e9fbb5490f0","type":"text","conversion_output":true,"parent_id":"659ff849d6c444b1b6d65a3c01c0f55f","text":"1.2 BACKGROUND ON ALTEPLASE","text_display":"\n\n\\subsection*{1.2 BACKGROUND ON ALTEPLASE}","confidence":0.99609375,"confidence_rate":0.9998776981256986},{"cnt":[[455,1944],[1493,1944],[1493,1996],[455,1996]],"region":{"top_left_x":455,"top_left_y":1944,"width":1039,"height":52},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39bd501a7f64441ba5875e0b161cb0ef","type":"section_header","conversion_output":false,"children_ids":["cdf3b1460d3a457ca62311ebab7f9bf4"],"text":"","text_display":""},{"cnt":[[460,1949],[1489,1949],[1489,1992],[460,1992]],"region":{"top_left_x":459,"top_left_y":1948,"width":1030,"height":44},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cdf3b1460d3a457ca62311ebab7f9bf4","type":"text","conversion_output":true,"parent_id":"39bd501a7f64441ba5875e0b161cb0ef","text":"1.2.1 Fibrinolysis and Tissue Plasminogen Activator","text_display":"\n\n\\subsection*{1.2.1 Fibrinolysis and Tissue Plasminogen Activator}","confidence":1,"confidence_rate":1},{"cnt":[[460,2007],[1687,2007],[1687,2047],[460,2047]],"region":{"top_left_x":459,"top_left_y":2006,"width":1228,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2bcc3e774034db09dd5833a720f95c9","type":"text","conversion_output":true,"text":"Physiologic dissolution of a thrombus depends primarily on the proteolytic action of","text_display":"\n\nPhysiologic dissolution of a thrombus depends primarily on the proteolytic action of","confidence":1,"confidence_rate":1},{"cnt":[[460,2050],[1772,2050],[1772,2095],[460,2095]],"region":{"top_left_x":459,"top_left_y":2049,"width":1314,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e15367cc1c4c4ef6af992260108d5795","type":"text","conversion_output":true,"text":"plasmin formed from plasminogen at the site of a clot. The mechanism for this activation","text_display":" plasmin formed from plasminogen at the site of a clot. The mechanism for this activation","confidence":1,"confidence_rate":1},{"cnt":[[460,2097],[1725,2097],[1725,2142],[460,2142]],"region":{"top_left_x":459,"top_left_y":2096,"width":1267,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb60a253964e459eb497898f705576b0","type":"text","conversion_output":true,"text":"in vivo has not been definitively established. Plasminogen, the zymogen precursor of","text_display":" in vivo has not been definitively established. Plasminogen, the zymogen precursor of","confidence":1,"confidence_rate":1},{"cnt":[[460,2144],[1721,2144],[1721,2185],[460,2185]],"region":{"top_left_x":459,"top_left_y":2144,"width":1262,"height":41},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9eb1bc180bb49ada08680b487566fcd","type":"text","conversion_output":true,"text":"plasmin, may be activated by substances found in the plasma milieu, in tissue (tissue","text_display":" plasmin, may be activated by substances found in the plasma milieu, in tissue (tissue","confidence":1,"confidence_rate":1},{"cnt":[[460,2187],[1751,2187],[1751,2232],[460,2232]],"region":{"top_left_x":459,"top_left_y":2187,"width":1292,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d80859eebf1e4e0581b4ea8d565406c7","type":"text","conversion_output":true,"text":"plasminogen activator [t-PA]), in urine (urokinase), and in bacteria (streptokinase). The","text_display":" plasminogen activator [t-PA]), in urine (urokinase), and in bacteria (streptokinase). The","confidence":0.9765625,"confidence_rate":0.9997477283511927},{"cnt":[[460,2234],[1699,2234],[1699,2277],[460,2277]],"region":{"top_left_x":459,"top_left_y":2234,"width":1241,"height":44},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a22ede09e224b548f2366cdb5c70a33","type":"text","conversion_output":true,"text":"generated plasmin may be inhibited by plasma proteins such as \\(\\alpha 2\\)-antiplasmin and","text_display":" generated plasmin may be inhibited by plasma proteins such as \\(\\alpha 2\\)-antiplasmin and","confidence":0.9917030334472656,"confidence_rate":0.9999063911460863},{"cnt":[[460,2282],[969,2282],[969,2322],[460,2322]],"region":{"top_left_x":459,"top_left_y":2281,"width":510,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c579763e68e48c185672017d294b94b","type":"text","conversion_output":true,"text":"\\(\\alpha 2\\)-macroglobulin (Robbins 1982).","text_display":" \\(\\alpha 2\\)-macroglobulin (Robbins 1982).","confidence":0.8344637621194124,"confidence_rate":0.9951209693950206},{"cnt":[[455,2376],[857,2376],[857,2417],[455,2417]],"region":{"top_left_x":455,"top_left_y":2376,"width":403,"height":41},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f319ef3ae43d450cb5274bac66fb0cf6","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9946362947812304,"confidence_rate":0.9998207446838158},{"cnt":[[460,2413],[900,2413],[900,2447],[460,2447]],"region":{"top_left_x":459,"top_left_y":2412,"width":442,"height":36},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04e8fc36a86140ad91d3827f9c136c28","type":"page_info","conversion_output":false,"text":"21/Protocol ML29093, Version 3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bc74ddc867b412c8e5cf6814e40c22a","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9912368957975559,"confidence_rate":0.9998645979984966},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e25d8ff853a548b996856737f0df7f74","type":"page_info","conversion_output":false,"text":"566/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-231","page":231,"lines":[{"cnt":[[460,391],[1601,391],[1601,432],[460,432]],"region":{"top_left_x":459,"top_left_y":391,"width":1142,"height":41},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61f10a5e45a04407b6852c6dc60d6ad4","type":"text","conversion_output":true,"text":"Kinetic analyses suggest that plasminogen activation in the presence of fibrin","text_display":"\n\nKinetic analyses suggest that plasminogen activation in the presence of fibrin","confidence":1,"confidence_rate":1},{"cnt":[[460,434],[1764,434],[1764,475],[460,475]],"region":{"top_left_x":459,"top_left_y":433,"width":1305,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca1a7256273c45c3b8acd87d6f4f4f09","type":"text","conversion_output":true,"text":"occurs after the binding of plasminogen and t-PA at the clot site. t-PA has a high affinity","text_display":" occurs after the binding of plasminogen and t-PA at the clot site. t-PA has a high affinity","confidence":1,"confidence_rate":1},{"cnt":[[460,481],[1745,481],[1745,522],[460,522]],"region":{"top_left_x":459,"top_left_y":481,"width":1286,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8de348c325664e7f915f5f7031d15b72","type":"text","conversion_output":true,"text":"for fibrin, thereby efficiently activating the fibrin-bound plasminogen and converting it to","text_display":" for fibrin, thereby efficiently activating the fibrin-bound plasminogen and converting it to","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[460,526],[1704,526],[1704,569],[460,569]],"region":{"top_left_x":459,"top_left_y":526,"width":1245,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96f0e3223a734cff86288e8df01a8ce6","type":"text","conversion_output":true,"text":"plasmin. Plasmin, which when bound to fibrin is protected from rapid inactivation by","text_display":" plasmin. Plasmin, which when bound to fibrin is protected from rapid inactivation by","confidence":1,"confidence_rate":1},{"cnt":[[460,571],[1257,571],[1257,612],[460,612]],"region":{"top_left_x":459,"top_left_y":571,"width":798,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19ea89c04e2f450a8402159b92529169","type":"text","conversion_output":true,"text":"\\(\\alpha 2\\)-antiplasmin, then proceeds to digest the fibrin clot.","text_display":" \\(\\alpha 2\\)-antiplasmin, then proceeds to digest the fibrin clot.","confidence":1,"confidence_rate":1},{"cnt":[[460,649],[1665,649],[1665,698],[460,698]],"region":{"top_left_x":459,"top_left_y":648,"width":1207,"height":51},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80f06b8cc2344189a2f0cfeed296a3ff","type":"text","conversion_output":true,"text":"See the Activase \\({ }^{\\text {® }}\\) (alteplase) U.S. Package Insert (USPI) for additional details on","text_display":"\n\nSee the Activase \\({ }^{\\text {® }}\\) (alteplase) U.S. Package Insert (USPI) for additional details on","confidence":0.72021484375,"confidence_rate":0.996818608110491},{"cnt":[[460,700],[917,700],[917,737],[460,737]],"region":{"top_left_x":459,"top_left_y":700,"width":459,"height":37},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb53ed8a41864cb6bba3608146185a96","type":"text","conversion_output":true,"text":"nonclinical and clinical studies.","text_display":" nonclinical and clinical studies.","confidence":1,"confidence_rate":1},{"cnt":[[455,769],[1644,769],[1644,819],[455,819]],"region":{"top_left_x":455,"top_left_y":769,"width":1189,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"204e2d66b7ad4947aa39ec3033d44e1b","type":"section_header","conversion_output":false,"children_ids":["44a201f0850f405eaac53364a79039db"],"text":"","text_display":""},{"cnt":[[460,773],[1639,773],[1639,814],[460,814]],"region":{"top_left_x":459,"top_left_y":773,"width":1181,"height":42},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44a201f0850f405eaac53364a79039db","type":"text","conversion_output":true,"parent_id":"204e2d66b7ad4947aa39ec3033d44e1b","text":"1.3 STUDY RATIONALE AND BENEFIT-RISK ASSESSMENT","text_display":"\n\n\\subsection*{1.3 STUDY RATIONALE AND BENEFIT-RISK ASSESSMENT}","confidence":0.99755859375,"confidence_rate":0.999952993579033},{"cnt":[[455,838],[1732,838],[1732,879],[455,879]],"region":{"top_left_x":455,"top_left_y":837,"width":1277,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db6aeda86e434267ad9edcf24c7278e2","type":"text","conversion_output":true,"text":"Alteplase is the only approved therapeutic agent for the treatment of AIS and is widely","text_display":"\n\nAlteplase is the only approved therapeutic agent for the treatment of AIS and is widely","confidence":1,"confidence_rate":1},{"cnt":[[460,885],[1523,885],[1523,926],[460,926]],"region":{"top_left_x":459,"top_left_y":885,"width":1065,"height":41},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3ac365c4afa476e89db5c543b522791","type":"text","conversion_output":true,"text":"accepted as the standard of care for eligible patients (Edlow et al. 2013;","text_display":" accepted as the standard of care for eligible patients (Edlow et al. 2013;","confidence":0.9990234375,"confidence_rate":0.9999876324859995},{"cnt":[[458,928],[1659,928],[1659,971],[458,971]],"region":{"top_left_x":457,"top_left_y":928,"width":1202,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"472e9644833f4b8d97ced10bf9a196c5","type":"text","conversion_output":true,"text":"Jauch et al. 2013). The currently approved alteplase USPI contains wording that","text_display":" Jauch et al. 2013). The currently approved alteplase USPI contains wording that","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[460,975],[1747,975],[1747,1016],[460,1016]],"region":{"top_left_x":459,"top_left_y":975,"width":1288,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36f016c7cd4f4aeeac9a62095f14719c","type":"text","conversion_output":true,"text":"recommends against use of alteplase in patients with \"minor neurological deficit or with","text_display":" recommends against use of alteplase in patients with \"minor neurological deficit or with","confidence":1,"confidence_rate":1},{"cnt":[[460,1018],[1747,1018],[1747,1061],[460,1061]],"region":{"top_left_x":459,"top_left_y":1018,"width":1288,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"604203729e3a4602b352793d4c3fccbe","type":"text","conversion_output":true,"text":"rapidly improving stroke symptoms\" due to the fact this patient population has not been","text_display":" rapidly improving stroke symptoms\" due to the fact this patient population has not been","confidence":1,"confidence_rate":1},{"cnt":[[460,1066],[1678,1066],[1678,1106],[460,1106]],"region":{"top_left_x":459,"top_left_y":1065,"width":1219,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d032e027cb3f464a954274114cbb5e3a","type":"text","conversion_output":true,"text":"evaluated. Furthermore, the current American Heart Association/American Stroke","text_display":" evaluated. Furthermore, the current American Heart Association/American Stroke","confidence":1,"confidence_rate":1},{"cnt":[[455,1111],[1729,1111],[1729,1154],[455,1154]],"region":{"top_left_x":455,"top_left_y":1110,"width":1275,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3976e9add930432d814d9a01534a7ab0","type":"text","conversion_output":true,"text":"Association Council Guidelines include \"minor and rapidly improving stroke symptoms","text_display":" Association Council Guidelines include \"minor and rapidly improving stroke symptoms","confidence":1,"confidence_rate":1},{"cnt":[[460,1156],[1493,1156],[1493,1199],[460,1199]],"region":{"top_left_x":459,"top_left_y":1155,"width":1035,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec60bf70df6f43a989aada4eeff516d6","type":"text","conversion_output":true,"text":"(clearing spontaneously)\" as a relative exclusion criterion for alteplase","text_display":" (clearing spontaneously)\" as a relative exclusion criterion for alteplase","confidence":1,"confidence_rate":1},{"cnt":[[460,1199],[1635,1199],[1635,1244],[460,1244]],"region":{"top_left_x":459,"top_left_y":1198,"width":1176,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b9d9302f3ac4a0baeea9a89d54e6dbd","type":"text","conversion_output":true,"text":"(Jauch et al. 2013). This is largely due to the aforementioned label wording not","text_display":" (Jauch et al. 2013). This is largely due to the aforementioned label wording not","confidence":1,"confidence_rate":1},{"cnt":[[460,1246],[1663,1246],[1663,1291],[460,1291]],"region":{"top_left_x":459,"top_left_y":1246,"width":1204,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f60472ded8c4d0aadff30179be602e5","type":"text","conversion_output":true,"text":"recommending treatment of patients with minor neurological deficit or with rapidly","text_display":" recommending treatment of patients with minor neurological deficit or with rapidly","confidence":1,"confidence_rate":1},{"cnt":[[460,1293],[1762,1293],[1762,1334],[460,1334]],"region":{"top_left_x":459,"top_left_y":1293,"width":1303,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a9fdef8a1754d6392297cf48db72203","type":"text","conversion_output":true,"text":"improving stroke symptoms (RISS), the lack of a consistent and consensus definition on","text_display":" improving stroke symptoms (RISS), the lack of a consistent and consensus definition on","confidence":1,"confidence_rate":1},{"cnt":[[458,1336],[1656,1336],[1656,1379],[458,1379]],"region":{"top_left_x":457,"top_left_y":1336,"width":1200,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22e1718619cb47acbad220793a94957e","type":"text","conversion_output":true,"text":"who constitutes this patient population, and the absence of definitive evidence of","text_display":" who constitutes this patient population, and the absence of definitive evidence of","confidence":0.984375,"confidence_rate":0.9998190007849999},{"cnt":[[458,1384],[1742,1384],[1742,1429],[458,1429]],"region":{"top_left_x":457,"top_left_y":1383,"width":1286,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c6e7602633e4690b66f78fdd32980f2","type":"text","conversion_output":true,"text":"alteplase efficacy in this setting (Levine et al. 2013). Therefore, this trial is designed to","text_display":" alteplase efficacy in this setting (Levine et al. 2013). Therefore, this trial is designed to","confidence":1,"confidence_rate":1},{"cnt":[[460,1429],[1656,1429],[1656,1472],[460,1472]],"region":{"top_left_x":459,"top_left_y":1428,"width":1198,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f00d30674632464bb68df78da214995f","type":"text","conversion_output":true,"text":"evaluate the efficacy and safety of alteplase in confirmed AIS patients with minor","text_display":" evaluate the efficacy and safety of alteplase in confirmed AIS patients with minor","confidence":1,"confidence_rate":1},{"cnt":[[460,1474],[1714,1474],[1714,1517],[460,1517]],"region":{"top_left_x":459,"top_left_y":1473,"width":1256,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6e068ff25cf46e49160c1f0ce75c637","type":"text","conversion_output":true,"text":"neurological deficit or with RISS, which will be referred to collectively as \"mild stroke\"","text_display":" neurological deficit or with RISS, which will be referred to collectively as \"mild stroke\"","confidence":1,"confidence_rate":1},{"cnt":[[458,1521],[819,1521],[819,1562],[458,1562]],"region":{"top_left_x":457,"top_left_y":1521,"width":362,"height":41},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a13a276c8324b7696f45774c74f1277","type":"text","conversion_output":true,"text":"throughout the protocol.","text_display":" throughout the protocol.","confidence":1,"confidence_rate":1},{"cnt":[[460,1603],[1760,1603],[1760,1646],[460,1646]],"region":{"top_left_x":459,"top_left_y":1602,"width":1301,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8327592e71144c0b09b19187c5e8f9e","type":"text","conversion_output":true,"text":"To date, all completed major randomized acute stroke trials have excluded patients with","text_display":"\n\nTo date, all completed major randomized acute stroke trials have excluded patients with","confidence":1,"confidence_rate":1},{"cnt":[[460,1650],[1732,1650],[1732,1691],[460,1691]],"region":{"top_left_x":459,"top_left_y":1650,"width":1273,"height":41},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aea6d33096274f71960c359316abb7e5","type":"text","conversion_output":true,"text":"mild strokes to varying degrees. In the two NINDS trials, such patients were excluded","text_display":" mild strokes to varying degrees. In the two NINDS trials, such patients were excluded","confidence":1,"confidence_rate":1},{"cnt":[[460,1693],[1772,1693],[1772,1738],[460,1738]],"region":{"top_left_x":459,"top_left_y":1692,"width":1314,"height":47},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f97a56b779bf47209a20609dd4615cd2","type":"text","conversion_output":true,"text":"according to the protocol (largely to prevent patients with transient ischemic attacks from","text_display":" according to the protocol (largely to prevent patients with transient ischemic attacks from","confidence":1,"confidence_rate":1},{"cnt":[[460,1740],[1734,1740],[1734,1781],[460,1781]],"region":{"top_left_x":459,"top_left_y":1740,"width":1275,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebb81ec999f34295b76943e17b64c17f","type":"text","conversion_output":true,"text":"being enrolled if they were having rapidly improving symptoms), but did not include an","text_display":" being enrolled if they were having rapidly improving symptoms), but did not include an","confidence":1,"confidence_rate":1},{"cnt":[[458,1783],[1742,1783],[1742,1828],[458,1828]],"region":{"top_left_x":457,"top_left_y":1783,"width":1286,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"953e496499934c5e80e58664b47fea95","type":"text","conversion_output":true,"text":"explicit definition of mild stroke except for pure sensory stroke, isolated ataxia, isolated","text_display":" explicit definition of mild stroke except for pure sensory stroke, isolated ataxia, isolated","confidence":1,"confidence_rate":1},{"cnt":[[458,1830],[1644,1830],[1644,1876],[458,1876]],"region":{"top_left_x":457,"top_left_y":1830,"width":1187,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51a233ba6d5a4abaaec3e273b8156c65","type":"text","conversion_output":true,"text":"dysarthria, and isolated facial weakness (NINDS rt-PA Study Group 1995). The","text_display":" dysarthria, and isolated facial weakness (NINDS rt-PA Study Group 1995). The","confidence":1,"confidence_rate":1},{"cnt":[[458,1876],[1725,1876],[1725,1919],[458,1919]],"region":{"top_left_x":457,"top_left_y":1875,"width":1269,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bdf9d34ea340497fbe349dc27208b828","type":"text","conversion_output":true,"text":"operational definition for stroke symptoms too mild to treat was left to the judgment of","text_display":" operational definition for stroke symptoms too mild to treat was left to the judgment of","confidence":1,"confidence_rate":1},{"cnt":[[458,1921],[1749,1921],[1749,1966],[458,1966]],"region":{"top_left_x":457,"top_left_y":1920,"width":1292,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f4ae4ec1a0f471fba9b85a5a557f8fb","type":"text","conversion_output":true,"text":"the randomizing physician (Levine et al. 2013). Interestingly, a post hoc analysis of the","text_display":" the randomizing physician (Levine et al. 2013). Interestingly, a post hoc analysis of the","confidence":1,"confidence_rate":1},{"cnt":[[460,1964],[1732,1964],[1732,2009],[460,2009]],"region":{"top_left_x":459,"top_left_y":1963,"width":1273,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0a02bdb01bd44318a00eabdc94f77cb","type":"text","conversion_output":true,"text":"624 patients in the NINDS trial revealed that there were 58 patients ( \\(9 \\%\\) ) enrolled with","text_display":" 624 patients in the NINDS trial revealed that there were 58 patients ( \\(9 \\%\\) ) enrolled with","confidence":0.9921875,"confidence_rate":0.9999207791233815},{"cnt":[[460,2011],[1747,2011],[1747,2056],[460,2056]],"region":{"top_left_x":459,"top_left_y":2010,"width":1288,"height":47},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f3ebd8d508e41acbe8a7e197364601e","type":"text","conversion_output":true,"text":"an NIHSS score \\(\\leq 5\\), none of whom had isolated motor symptoms, isolated facial droop,","text_display":" an NIHSS score \\(\\leq 5\\), none of whom had isolated motor symptoms, isolated facial droop,","confidence":1,"confidence_rate":1},{"cnt":[[458,2058],[1704,2058],[1704,2099],[458,2099]],"region":{"top_left_x":457,"top_left_y":2058,"width":1247,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5dc7f5cc71bc40e4a90123f8bf7bcfb2","type":"text","conversion_output":true,"text":"isolated ataxia, dysarthria, isolated sensory, and three or fewer of each of additional","text_display":" isolated ataxia, dysarthria, isolated sensory, and three or fewer of each of additional","confidence":1,"confidence_rate":1},{"cnt":[[458,2101],[1699,2101],[1699,2146],[458,2146]],"region":{"top_left_x":457,"top_left_y":2101,"width":1243,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47ddfe5f61534250a4863bebf198da79","type":"text","conversion_output":true,"text":"isolated deficits (Khatri et al. 2010). Perhaps more significantly, 2971 patients were","text_display":" isolated deficits (Khatri et al. 2010). Perhaps more significantly, 2971 patients were","confidence":1,"confidence_rate":1},{"cnt":[[460,2148],[1635,2148],[1635,2191],[460,2191]],"region":{"top_left_x":459,"top_left_y":2148,"width":1176,"height":44},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d830da40e9242d087b1f83e69508c5e","type":"text","conversion_output":true,"text":"excluded primarily due to \"rapidly improving\" or \"minor symptoms.\" However, a","text_display":" excluded primarily due to \"rapidly improving\" or \"minor symptoms.\" However, a","confidence":1,"confidence_rate":1},{"cnt":[[458,2196],[1734,2196],[1734,2237],[458,2237]],"region":{"top_left_x":457,"top_left_y":2195,"width":1277,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a80172ce52374686a9ebad567235a607","type":"text","conversion_output":true,"text":"significant unmet medical need exists for patients with mild stroke. Available outcome","text_display":" significant unmet medical need exists for patients with mild stroke. Available outcome","confidence":1,"confidence_rate":1},{"cnt":[[460,2239],[1755,2239],[1755,2282],[460,2282]],"region":{"top_left_x":459,"top_left_y":2238,"width":1297,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18e75636f7cd40d38d13294ed40f72b3","type":"text","conversion_output":true,"text":"data for patients with mild stroke who do not receive alteplase consistently demonstrate","text_display":" data for patients with mild stroke who do not receive alteplase consistently demonstrate","confidence":1,"confidence_rate":1},{"cnt":[[460,2286],[1760,2286],[1760,2329],[460,2329]],"region":{"top_left_x":459,"top_left_y":2285,"width":1301,"height":44},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba2f83f54f7c4245ba135e64666b30d8","type":"text","conversion_output":true,"text":"a high rate of suboptimal outcomes. 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Khatri et al. 2012;","text_display":" Scale [mRS] score 2-6) at 90 days (Fischer et al. 2010; Khatri et al. 2012;","confidence":0.9990236759185791,"confidence_rate":0.9999882313825493},{"cnt":[[679,524],[1085,524],[1085,569],[679,569]],"region":{"top_left_x":678,"top_left_y":524,"width":407,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90ee8e4122e94415b35a2acb492c0a7f","type":"text","conversion_output":true,"text":", personal communication).","text_display":" , personal communication).","confidence":1,"confidence_rate":1},{"cnt":[[458,606],[1725,606],[1725,651],[458,651]],"region":{"top_left_x":457,"top_left_y":605,"width":1269,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c499d27bb9e4effb8c5967679daca47","type":"text","conversion_output":true,"text":"Existing, albeit limited, data suggest that the potential benefit-risk ratio for alteplase in","text_display":"\n\nExisting, albeit limited, data suggest that the potential benefit-risk ratio for alteplase in","confidence":1,"confidence_rate":1},{"cnt":[[460,653],[1639,653],[1639,694],[460,694]],"region":{"top_left_x":459,"top_left_y":653,"width":1181,"height":41},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57e4204ac6c242b8b4869b16cac97f48","type":"text","conversion_output":true,"text":"mild stroke should be favorable. Gonzales et al. demonstrated better functional","text_display":" mild stroke should be favorable. Gonzales et al. demonstrated better functional","confidence":1,"confidence_rate":1},{"cnt":[[458,700],[1764,700],[1764,741],[458,741]],"region":{"top_left_x":457,"top_left_y":700,"width":1307,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ac993d8e8de42bda33f82517ed7b8e2","type":"text","conversion_output":true,"text":"outcomes among mild strokes treated with IV alteplase compared to those not treated in","text_display":" outcomes among mild strokes treated with IV alteplase compared to those not treated in","confidence":1,"confidence_rate":1},{"cnt":[[458,743],[1757,743],[1757,788],[458,788]],"region":{"top_left_x":457,"top_left_y":743,"width":1301,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14fa79b454be4c488fbd28d80977f953","type":"text","conversion_output":true,"text":"a large, single-center, retrospective cohort; this was shown with two different thresholds","text_display":" a large, single-center, retrospective cohort; this was shown with two different thresholds","confidence":1,"confidence_rate":1},{"cnt":[[458,786],[1695,786],[1695,834],[458,834]],"region":{"top_left_x":457,"top_left_y":786,"width":1239,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88349924eebf4e7b9f062f7ee6f83dcf","type":"text","conversion_output":true,"text":"of stroke severity (NIHSS \\(\\leq 7\\) and NIHSS \\(\\leq 3\\) ) (Gonzales et al. 2006). Additionally, a","text_display":" of stroke severity (NIHSS \\(\\leq 7\\) and NIHSS \\(\\leq 3\\) ) (Gonzales et al. 2006). Additionally, a","confidence":0.9990236759185791,"confidence_rate":0.9999896085540316},{"cnt":[[458,834],[1678,834],[1678,879],[458,879]],"region":{"top_left_x":457,"top_left_y":833,"width":1221,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc62f21ddf554090a1acb6aad254afbe","type":"text","conversion_output":true,"text":"recent post hoc analysis of the subset of the third International Stroke Trial (IST-3)","text_display":" recent post hoc analysis of the subset of the third International Stroke Trial (IST-3)","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[458,881],[1768,881],[1768,924],[458,924]],"region":{"top_left_x":457,"top_left_y":880,"width":1312,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e81e9c863d9c4295a73ad3e0f266df96","type":"text","conversion_output":true,"text":"patients with mild strokes (pre-treatment NIHSS \\(\\leq 5\\) who met all other NINDS rt-PA study","text_display":" patients with mild strokes (pre-treatment NIHSS \\(\\leq 5\\) who met all other NINDS rt-PA study","confidence":1,"confidence_rate":1},{"cnt":[[460,924],[1747,924],[1747,980],[460,980]],"region":{"top_left_x":459,"top_left_y":923,"width":1288,"height":57},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2719903057d34f1086c15368b711e9d6","type":"text","conversion_output":true,"text":"eligibility criteria) showed a trend toward benefit for alteplase □ , personal","text_display":" eligibility criteria) showed a trend toward benefit for alteplase □ , personal","confidence":0.8768181800842285,"confidence_rate":0.9984174508016705},{"cnt":[[460,971],[1755,971],[1755,1016],[460,1016]],"region":{"top_left_x":459,"top_left_y":971,"width":1297,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"badb5e1c0b2a4f0aa0f1f4e195da9eed","type":"text","conversion_output":true,"text":"communication). For PRISMS, the primary efficacy outcome assumption ( \\(mRS 0-1\\) ) is","text_display":" communication). For PRISMS, the primary efficacy outcome assumption ( \\(mRS 0-1\\) ) is","confidence":0.8535151778706617,"confidence_rate":0.9982798295202177},{"cnt":[[458,1018],[1687,1018],[1687,1061],[458,1061]],"region":{"top_left_x":457,"top_left_y":1018,"width":1230,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c428e3ccbfb48afb17f80795d485e00","type":"text","conversion_output":true,"text":"a \\(9 \\%\\) absolute treatment effect of alteplase relative to placebo. This assumption is","text_display":" a \\(9 \\%\\) absolute treatment effect of alteplase relative to placebo. This assumption is","confidence":1,"confidence_rate":1},{"cnt":[[458,1061],[1749,1061],[1749,1106],[458,1106]],"region":{"top_left_x":457,"top_left_y":1061,"width":1292,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec4103c9eec349468a6aca70c270026f","type":"text","conversion_output":true,"text":"based on several retrospective analyses of similar patient populations (Köhrmann et al.","text_display":" based on several retrospective analyses of similar patient populations (Köhrmann et al.","confidence":1,"confidence_rate":1},{"cnt":[[458,1106],[1641,1106],[1641,1154],[458,1154]],"region":{"top_left_x":457,"top_left_y":1106,"width":1185,"height":48},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f04e945abdd54ae79d60277f54dc9fe9","type":"text","conversion_output":true,"text":"2009; Fischer el al. 2010; Hassan et al. 2010b; Khatri et al. 2012) as well as the","text_display":" 2009; Fischer el al. 2010; Hassan et al. 2010b; Khatri et al. 2012) as well as the","confidence":1,"confidence_rate":1},{"cnt":[[458,1152],[1766,1152],[1766,1201],[458,1201]],"region":{"top_left_x":457,"top_left_y":1151,"width":1310,"height":50},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f5599a386a945ceb0848c6562f8191c","type":"text","conversion_output":true,"text":"aforementioned IST-3 trial subgroup analysis , personal communication).","text_display":" aforementioned IST-3 trial subgroup analysis , personal communication).","confidence":1,"confidence_rate":1},{"cnt":[[458,1238],[1738,1238],[1738,1280],[458,1280]],"region":{"top_left_x":457,"top_left_y":1237,"width":1282,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9256d7fe5bc4ba6a30efc4ba350a0fa","type":"text","conversion_output":true,"text":"The most prevalently reported and life-threatening adverse event (AE) associated with","text_display":"\n\nThe most prevalently reported and life-threatening adverse event (AE) associated with","confidence":1,"confidence_rate":1},{"cnt":[[458,1283],[1721,1283],[1721,1326],[458,1326]],"region":{"top_left_x":457,"top_left_y":1282,"width":1264,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"912316b6c89a4faa915d549ee54d6f05","type":"text","conversion_output":true,"text":"alteplase treatment for acute ischemic stroke is symptomatic intracranial hemorrhage","text_display":" alteplase treatment for acute ischemic stroke is symptomatic intracranial hemorrhage","confidence":0.99755859375,"confidence_rate":0.9999725353059057},{"cnt":[[460,1328],[1738,1328],[1738,1371],[460,1371]],"region":{"top_left_x":459,"top_left_y":1327,"width":1280,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee1e1cedff18401e8c448f1bd1ab6337","type":"text","conversion_output":true,"text":"(sICH). Post hoc analyses, case series, and retrospective studies in patients with mild","text_display":" (sICH). Post hoc analyses, case series, and retrospective studies in patients with mild","confidence":1,"confidence_rate":1},{"cnt":[[458,1371],[1721,1371],[1721,1418],[458,1418]],"region":{"top_left_x":457,"top_left_y":1370,"width":1264,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77a3d9bcb71c4b408eff3737f9e68282","type":"text","conversion_output":true,"text":"stroke suggest an absolute sICH rate of \\(0-2 \\%\\) with alteplase treatment (NINDS rt-PA","text_display":" stroke suggest an absolute sICH rate of \\(0-2 \\%\\) with alteplase treatment (NINDS rt-PA","confidence":0.6309103965759277,"confidence_rate":0.9948953904845811},{"cnt":[[460,1418],[1652,1418],[1652,1463],[460,1463]],"region":{"top_left_x":459,"top_left_y":1417,"width":1194,"height":47},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63555a6348124137b5fb99083bc8ee92","type":"text","conversion_output":true,"text":"Study Group 2005; Baumann 2006; Gonzales et al. 2006; Köhrmann et al. 2009;","text_display":" Study Group 2005; Baumann 2006; Gonzales et al. 2006; Köhrmann et al. 2009;","confidence":1,"confidence_rate":1},{"cnt":[[460,1465],[1749,1465],[1749,1508],[460,1508]],"region":{"top_left_x":459,"top_left_y":1465,"width":1290,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39f93688549d425e806016c856dbddbe","type":"text","conversion_output":true,"text":"Steffenhagen et al. 2009; Hassan et al. 2010a; Hassan et al. 2010b; Huisa et al. 2012).","text_display":" Steffenhagen et al. 2009; Hassan et al. 2010a; Hassan et al. 2010b; Huisa et al. 2012).","confidence":1,"confidence_rate":1},{"cnt":[[458,1508],[1721,1508],[1721,1553],[458,1553]],"region":{"top_left_x":457,"top_left_y":1508,"width":1264,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b56b7f676d7d48f5af2ba03de2d24f10","type":"text","conversion_output":true,"text":"These data are consistent with analyses of IV alteplase trials of more severe patients","text_display":" These data are consistent with analyses of IV alteplase trials of more severe patients","confidence":1,"confidence_rate":1},{"cnt":[[458,1555],[1745,1555],[1745,1601],[458,1601]],"region":{"top_left_x":457,"top_left_y":1555,"width":1288,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98dd5f670a7d46ea8fe8e1990b37f19f","type":"text","conversion_output":true,"text":"suggesting that stroke severity, as measured by the NIHSS score, is a strong predictor","text_display":" suggesting that stroke severity, as measured by the NIHSS score, is a strong predictor","confidence":1,"confidence_rate":1},{"cnt":[[458,1601],[1764,1601],[1764,1644],[458,1644]],"region":{"top_left_x":457,"top_left_y":1600,"width":1307,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34fd989514cc4d0bb66ecb0b3ff6f8b7","type":"text","conversion_output":true,"text":"of sICH risk (Khatri et al. 2007). No data exist to estimate the sICH rate for patients with","text_display":" of sICH risk (Khatri et al. 2007). No data exist to estimate the sICH rate for patients with","confidence":0.9873046875,"confidence_rate":0.999868291286942},{"cnt":[[458,1646],[1734,1646],[1734,1691],[458,1691]],"region":{"top_left_x":457,"top_left_y":1645,"width":1277,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"408aa4d97b404805b1139ed5574845bd","type":"text","conversion_output":true,"text":"mild stroke who did not receive t-PA; therefore, for this study, we are using a \\(0 \\%\\) sICH","text_display":" mild stroke who did not receive t-PA; therefore, for this study, we are using a \\(0 \\%\\) sICH","confidence":0.9960954189300537,"confidence_rate":0.9999588195442787},{"cnt":[[458,1693],[1689,1693],[1689,1738],[458,1738]],"region":{"top_left_x":457,"top_left_y":1692,"width":1232,"height":47},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f85966d5824f45f5a04f4a6337fb9341","type":"text","conversion_output":true,"text":"rate for the placebo arm, which is likely a conservative estimate. An absolute sICH","text_display":" rate for the placebo arm, which is likely a conservative estimate. An absolute sICH","confidence":1,"confidence_rate":1},{"cnt":[[458,1738],[1656,1738],[1656,1781],[458,1781]],"region":{"top_left_x":457,"top_left_y":1738,"width":1200,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"967d2681dfb7460595563473cf6ea97f","type":"text","conversion_output":true,"text":"difference of \\(2 \\%\\) at 36 hours (primary safety endpoint) has been assumed for the","text_display":" difference of \\(2 \\%\\) at 36 hours (primary safety endpoint) has been assumed for the","confidence":1,"confidence_rate":1},{"cnt":[[458,1783],[1725,1783],[1725,1828],[458,1828]],"region":{"top_left_x":457,"top_left_y":1783,"width":1269,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b01ba596fac1463297352064cec5b220","type":"text","conversion_output":true,"text":"alteplase arm vs. the placebo control arm in the proposed study. For this study, sICH","text_display":" alteplase arm vs. the placebo control arm in the proposed study. For this study, sICH","confidence":1,"confidence_rate":1},{"cnt":[[458,1826],[1742,1826],[1742,1871],[458,1871]],"region":{"top_left_x":457,"top_left_y":1826,"width":1286,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e97c2a543c04069bd50b9abf1a7d410","type":"text","conversion_output":true,"text":"has been defined as any neurologic decline attributed to intracranial hemorrhage (ICH)","text_display":" has been defined as any neurologic decline attributed to intracranial hemorrhage (ICH)","confidence":0.99169921875,"confidence_rate":0.9999084061226785},{"cnt":[[458,1873],[1729,1873],[1729,1919],[458,1919]],"region":{"top_left_x":457,"top_left_y":1873,"width":1273,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a58d1539d3554cedb286a0513bc13ee0","type":"text","conversion_output":true,"text":"seen on imaging by the local investigator within 36 hours of study drug administration,","text_display":" seen on imaging by the local investigator within 36 hours of study drug administration,","confidence":1,"confidence_rate":1},{"cnt":[[458,1919],[1699,1919],[1699,1962],[458,1962]],"region":{"top_left_x":457,"top_left_y":1918,"width":1243,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94a4049f5c5f4e0c93b99c47e69bd377","type":"text","conversion_output":true,"text":"consistent with the NINDS trial definition for sICH (NINDS rt-PA Study Group 1995).","text_display":" consistent with the NINDS trial definition for sICH (NINDS rt-PA Study Group 1995).","confidence":1,"confidence_rate":1},{"cnt":[[455,2002],[1729,2002],[1729,2047],[455,2047]],"region":{"top_left_x":455,"top_left_y":2002,"width":1275,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7d295f37d3646f586478c3092579804","type":"text","conversion_output":true,"text":"Assuming the proposed study demonstrates both a \\(9 \\%\\) absolute treatment effect rate,","text_display":"\n\nAssuming the proposed study demonstrates both a \\(9 \\%\\) absolute treatment effect rate,","confidence":1,"confidence_rate":1},{"cnt":[[455,2047],[1738,2047],[1738,2090],[455,2090]],"region":{"top_left_x":455,"top_left_y":2047,"width":1284,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00134f81955a4ae99dcb57740ad4d6fc","type":"text","conversion_output":true,"text":"the number of patients needed to treat (NNT) to show benefit (i.e., mRS score of \\(0-1\\) )","text_display":" the number of patients needed to treat (NNT) to show benefit (i.e., mRS score of \\(0-1\\) )","confidence":0.8934881828342895,"confidence_rate":0.9988744122479171},{"cnt":[[455,2093],[1772,2093],[1772,2138],[455,2138]],"region":{"top_left_x":455,"top_left_y":2092,"width":1318,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"493fb24d02b74b3fabe17807bb348bdc","type":"text","conversion_output":true,"text":"for one patient is 11 . Assuming a \\(2 \\%\\) absolute difference in sICH rate in patients treated","text_display":" for one patient is 11 . Assuming a \\(2 \\%\\) absolute difference in sICH rate in patients treated","confidence":0.9970715045928955,"confidence_rate":0.9999709628786162},{"cnt":[[458,2140],[1624,2140],[1624,2185],[458,2185]],"region":{"top_left_x":457,"top_left_y":2139,"width":1168,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b356b99bad64c1ea3c6f552842c6c3b","type":"text","conversion_output":true,"text":"with alteplase, the corresponding value for the number needed to harm (NNH),","text_display":" with alteplase, the corresponding value for the number needed to harm (NNH),","confidence":1,"confidence_rate":1},{"cnt":[[458,2185],[1742,2185],[1742,2228],[458,2228]],"region":{"top_left_x":457,"top_left_y":2184,"width":1286,"height":44},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f2f3a8501f464f279de7522ccae1bdb7","type":"text","conversion_output":true,"text":"specifically for sICH, is conservatively estimated to be 50 . The actual number NNH, or","text_display":" specifically for sICH, is conservatively estimated to be 50 . The actual number NNH, or","confidence":0.6092023849487305,"confidence_rate":0.9947966923158328},{"cnt":[[458,2230],[1674,2230],[1674,2273],[458,2273]],"region":{"top_left_x":457,"top_left_y":2230,"width":1217,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7007f3280ee449338479917663e0db26","type":"text","conversion_output":true,"text":"the number of patients who would have worse outcomes at 90 days with alteplase","text_display":" the number of patients who would have worse outcomes at 90 days with alteplase","confidence":1,"confidence_rate":1},{"cnt":[[458,2277],[1760,2277],[1760,2320],[458,2320]],"region":{"top_left_x":457,"top_left_y":2277,"width":1303,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2f88df8d89745aa8360f320652bfb81","type":"text","conversion_output":true,"text":"compared to placebo treatment, is likely to be much higher than is reflected by the sICH","text_display":" compared to placebo treatment, is likely to be much higher than is reflected by the sICH","confidence":1,"confidence_rate":1},{"cnt":[[455,2376],[857,2376],[857,2417],[455,2417]],"region":{"top_left_x":455,"top_left_y":2376,"width":403,"height":41},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02a61e7e977f4d8ab2999bdd6cbd617b","type":"text","conversion_output":true,"text":"Alteplase-Genentech, Inc.","text_display":"\n\nAlteplase-Genentech, Inc.","confidence":0.9956109506310895,"confidence_rate":0.9998533870979761},{"cnt":[[458,2411],[900,2411],[900,2449],[458,2449]],"region":{"top_left_x":457,"top_left_y":2410,"width":444,"height":40},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ae59b3cc51e4349a8134327f93147d0","type":"text","conversion_output":true,"text":"23/Protocol ML29093, Version 3","text_display":"\n23/Protocol ML29093, Version 3","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":44},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1060edbe0a64be68410ac7e5966dbf9","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9960992303683724,"confidence_rate":0.9999398726157812},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40f2575ff8d448f8abbda6a7d89272ec","type":"page_info","conversion_output":false,"text":"568/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-233","page":233,"lines":[{"cnt":[[460,391],[1775,391],[1775,432],[460,432]],"region":{"top_left_x":459,"top_left_y":391,"width":1316,"height":41},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54a2504938804c538d43d02c7561a580","type":"text","conversion_output":true,"text":"rate alone, as many patients who experience sICH have severe baseline infarcts and are","text_display":"\nrate alone, as many patients who experience sICH have severe baseline infarcts and are","confidence":1,"confidence_rate":1},{"cnt":[[460,434],[1079,434],[1079,477],[460,477]],"region":{"top_left_x":459,"top_left_y":433,"width":620,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9b7bc25b5174ad78ead5192023ba14b","type":"text","conversion_output":true,"text":"destined for poor outcomes (Saver 2007).","text_display":" destined for poor outcomes (Saver 2007).","confidence":0.99951171875,"confidence_rate":0.9999891467144949},{"cnt":[[460,518],[1704,518],[1704,561],[460,561]],"region":{"top_left_x":459,"top_left_y":517,"width":1245,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c9da4fc13524fcab7329140473ad160","type":"text","conversion_output":true,"text":"For comparison, the absolute treatment effect for mRS score of \\(0-1\\) at 90 days was","text_display":"\n\nFor comparison, the absolute treatment effect for mRS score of \\(0-1\\) at 90 days was","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[460,563],[1783,563],[1783,604],[460,604]],"region":{"top_left_x":459,"top_left_y":562,"width":1325,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecc8d97859244182bd89ea16b48bffdb","type":"text","conversion_output":true,"text":"\\(13 \\%\\) for the NINDS-sponsored pivotal study for alteplase. This equates to an NNT of 7.9.","text_display":" \\(13 \\%\\) for the NINDS-sponsored pivotal study for alteplase. This equates to an NNT of 7.9.","confidence":0.9956088066101074,"confidence_rate":0.9999516400375413},{"cnt":[[460,610],[1601,610],[1601,651],[460,651]],"region":{"top_left_x":459,"top_left_y":610,"width":1142,"height":41},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"05cbbaf1775e4a34885962074076686d","type":"text","conversion_output":true,"text":"In the same study, the absolute difference in sICH was \\(5.8 \\%\\) at \\(24 \\pm 12\\) hours","text_display":" In the same study, the absolute difference in sICH was \\(5.8 \\%\\) at \\(24 \\pm 12\\) hours","confidence":0.9907269477844238,"confidence_rate":0.9998904023048347},{"cnt":[[460,655],[1476,655],[1476,698],[460,698]],"region":{"top_left_x":459,"top_left_y":655,"width":1017,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d50c8e6030b4482994bf3958ee67672","type":"text","conversion_output":true,"text":"post-treatment, or an NNH of 17.2 (NINDS rt-PA Study Group 1995).","text_display":" post-treatment, or an NNH of 17.2 (NINDS rt-PA Study Group 1995).","confidence":1,"confidence_rate":1},{"cnt":[[455,728],[1388,728],[1388,780],[455,780]],"region":{"top_left_x":455,"top_left_y":728,"width":933,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5b45e2dc0564f908b3a4f66fb1528ca","type":"figure_label","conversion_output":false,"text":"Table 1 Comparison of PRISMS and NINDS 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IV alteplase/IV","confidence":1,"confidence_rate":1},{"cnt":[[460,649],[1738,649],[1738,690],[460,690]],"region":{"top_left_x":459,"top_left_y":648,"width":1280,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4d7955b9efc42ce8df3a5cb71461e7e","type":"text","conversion_output":true,"text":"alteplase placebo MAY NOT be initiated beyond 3 hours of last known well time under","text_display":" alteplase placebo MAY NOT be initiated beyond 3 hours of last known well time under","confidence":1,"confidence_rate":1},{"cnt":[[460,696],[750,696],[750,735],[460,735]],"region":{"top_left_x":459,"top_left_y":696,"width":291,"height":39},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb88d5d13ef041eaaf6d04f3e79e5fd5","type":"text","conversion_output":true,"text":"any circumstances.","text_display":" any circumstances.","confidence":1,"confidence_rate":1},{"cnt":[[458,778],[1321,778],[1321,819],[458,819]],"region":{"top_left_x":457,"top_left_y":777,"width":865,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"446cb4ce82d94938826364a0ae59d3e9","type":"text","conversion_output":true,"text":"A full schedule of assessments is provided in Appendix 1.","text_display":"\n\nA full schedule of assessments is provided in Appendix 1.","confidence":0.9775390625,"confidence_rate":0.9996276590691414},{"cnt":[[460,855],[1111,855],[1111,896],[460,896]],"region":{"top_left_x":459,"top_left_y":855,"width":652,"height":41},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a7cf7301e3142bbaa2a01fb04cde9bf","type":"figure_label","conversion_output":false,"text":"Figure 1 Abbreviated Study Schema","text_display":"","confidence":0.9970703125,"confidence_rate":0.9999284418912624},{"cnt":[[468,937],[1757,937],[1757,1517],[468,1517]],"region":{"top_left_x":468,"top_left_y":936,"width":1290,"height":581},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ba96ace6ac62422f8599ca487dc551ae","type":"diagram","conversion_output":true,"selected_labels":["0a7cf7301e3142bbaa2a01fb04cde9bf"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 1 Abbreviated Study Schema}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-235.jpg?height=581&width=1290&top_left_y=936&top_left_x=468}\n\\end{figure}"},{"cnt":[[462,1553],[1772,1553],[1772,1590],[462,1590]],"region":{"top_left_x":461,"top_left_y":1553,"width":1312,"height":37},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df20564b78a54728a1b086c1d797d03f","type":"text","conversion_output":true,"text":"ASA = aspirin; CT= computed tomography; IV=intravenous; MRI= magnetic resonance imaging;","text_display":"\n\nASA = aspirin; CT= computed tomography; IV=intravenous; MRI= magnetic resonance imaging;","confidence":0.7717158075655939,"confidence_rate":0.9972174385030182},{"cnt":[[494,1590],[1596,1590],[1596,1626],[494,1626]],"region":{"top_left_x":494,"top_left_y":1589,"width":1103,"height":38},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d5392f0855a4534ac26f83eaa5107ad","type":"text","conversion_output":true,"text":"mRS \\(=\\) modified Rankin Scale; NIHSS \\(=\\) National Institutes of Health Stroke Scale.","text_display":" mRS \\(=\\) modified Rankin Scale; NIHSS \\(=\\) National Institutes of Health Stroke Scale.","confidence":0.6670372261321386,"confidence_rate":0.9955603304971918},{"cnt":[[460,1669],[1729,1669],[1729,1710],[460,1710]],"region":{"top_left_x":459,"top_left_y":1669,"width":1271,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf8e985d17304f6aba55589b2e57568d","type":"text","conversion_output":true,"text":"Due to the emergency nature of randomization in acute stroke clinical trials, treatment","text_display":"\n\nDue to the emergency nature of randomization in acute stroke clinical trials, treatment","confidence":1,"confidence_rate":1},{"cnt":[[460,1714],[1770,1714],[1770,1755],[460,1755]],"region":{"top_left_x":459,"top_left_y":1714,"width":1312,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd11bff160eb405398dda7869c50e32e","type":"text","conversion_output":true,"text":"assignments must be made in an expeditious manner that also ensures even distribution","text_display":" assignments must be made in an expeditious manner that also ensures even distribution","confidence":1,"confidence_rate":1},{"cnt":[[460,1762],[1764,1762],[1764,1803],[460,1803]],"region":{"top_left_x":459,"top_left_y":1761,"width":1305,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ef5794d03c34aca8bb4f7e7b6bcc510","type":"text","conversion_output":true,"text":"in the treatment groups. A \"step forward\" randomization regimen stratified by site will be","text_display":" in the treatment groups. A \"step forward\" randomization regimen stratified by site will be","confidence":1,"confidence_rate":1},{"cnt":[[460,1805],[1682,1805],[1682,1846],[460,1846]],"region":{"top_left_x":459,"top_left_y":1804,"width":1224,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56e4288d73dd4fc3b3b9724ffad1851c","type":"text","conversion_output":true,"text":"used to ensure that a randomized treatment assignment is available upon patients'","text_display":" used to ensure that a randomized treatment assignment is available upon patients'","confidence":1,"confidence_rate":1},{"cnt":[[460,1850],[1682,1850],[1682,1893],[460,1893]],"region":{"top_left_x":459,"top_left_y":1849,"width":1224,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d63b44689984c1cb8586329ddf7bfb3","type":"text","conversion_output":true,"text":"arrival at the hospital and treatment can initiate immediately upon signing informed","text_display":" arrival at the hospital and treatment can initiate immediately upon signing informed","confidence":1,"confidence_rate":1},{"cnt":[[460,1895],[1734,1895],[1734,1936],[460,1936]],"region":{"top_left_x":459,"top_left_y":1894,"width":1275,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69dca258dfb44a249249b40e2e09ffdd","type":"text","conversion_output":true,"text":"consent and eligibility confirmation. Further details on step forward randomization can","text_display":" consent and eligibility confirmation. Further details on step forward randomization can","confidence":1,"confidence_rate":1},{"cnt":[[460,1942],[1519,1942],[1519,1983],[460,1983]],"region":{"top_left_x":459,"top_left_y":1942,"width":1060,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42f6506f623b4ae0bf1c522dc75298ad","type":"text","conversion_output":true,"text":"be found in Section 4.2, Method of Treatment Assignment and Blinding.","text_display":" be found in Section 4.2, Method of Treatment Assignment and Blinding.","confidence":1,"confidence_rate":1},{"cnt":[[458,2024],[1676,2024],[1676,2065],[458,2065]],"region":{"top_left_x":457,"top_left_y":2023,"width":1219,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfb11728a6ef453b8b1cd07ff3cf5dbc","type":"text","conversion_output":true,"text":"An independent Data Monitoring Committee (iDMC) will provide ongoing review of","text_display":"\n\nAn independent Data Monitoring Committee (iDMC) will provide ongoing review of","confidence":0.8310546875,"confidence_rate":0.9977728491260767},{"cnt":[[460,2071],[1704,2071],[1704,2112],[460,2112]],"region":{"top_left_x":459,"top_left_y":2071,"width":1245,"height":41},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3804c2e8e9984c0a8b3f2dec339c4b0a","type":"text","conversion_output":true,"text":"potential safety concerns and review efficacy and safety outcomes to inform a futility","text_display":" potential safety concerns and review efficacy and safety outcomes to inform a futility","confidence":1,"confidence_rate":1},{"cnt":[[460,2118],[1697,2118],[1697,2159],[460,2159]],"region":{"top_left_x":459,"top_left_y":2118,"width":1239,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"207b0070680f439eaccbcd4cb2d39b09","type":"text","conversion_output":true,"text":"interim analysis after 50\\% of patients have achieved the primary endpoint (following","text_display":" interim analysis after 50\\% of patients have achieved the primary endpoint (following","confidence":0.943359375,"confidence_rate":0.9993450688151948},{"cnt":[[460,2161],[1665,2161],[1665,2202],[460,2202]],"region":{"top_left_x":459,"top_left_y":2161,"width":1207,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"067e0ce66a5248428d8ce9bc8c2a3d29","type":"text","conversion_output":true,"text":"completion of the Day 90 visit). The composition of the iDMC and analysis will be","text_display":" completion of the Day 90 visit). The composition of the iDMC and analysis will be","confidence":1,"confidence_rate":1},{"cnt":[[460,2209],[1188,2209],[1188,2249],[460,2249]],"region":{"top_left_x":459,"top_left_y":2208,"width":730,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d70826cea6cd4302b7458edf31b40c5d","type":"text","conversion_output":true,"text":"documented in detail in a separate iDMC charter.","text_display":" documented in detail in a separate iDMC charter.","confidence":1,"confidence_rate":1},{"cnt":[[460,2376],[855,2376],[855,2413],[460,2413]],"region":{"top_left_x":459,"top_left_y":2376,"width":397,"height":37},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"542d4a5e7c864c25b762a6ef0ead0772","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, 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The LPLV is","text_display":"\n\nThe end of the study is defined as the date when the LPLV occurs. The LPLV is","confidence":1,"confidence_rate":1},{"cnt":[[460,718],[1768,718],[1768,758],[460,758]],"region":{"top_left_x":459,"top_left_y":717,"width":1310,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b7a807d07474c6080dabd3e2fb2123d","type":"text","conversion_output":true,"text":"expected to occur approximately 90 days ( \\(\\pm 14\\) days) after the last patient is enrolled into","text_display":" expected to occur approximately 90 days ( \\(\\pm 14\\) days) after the last patient is enrolled into","confidence":0.9133058199060938,"confidence_rate":0.9991113314439911},{"cnt":[[460,765],[608,765],[608,806],[460,806]],"region":{"top_left_x":459,"top_left_y":764,"width":150,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3b1684f7132499d94c02a982c7a4c75","type":"text","conversion_output":true,"text":"the study.","text_display":" the 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The primary endpoint using the mRS assessment of global disability at","confidence":0.85986328125,"confidence_rate":0.9982857678220213},{"cnt":[[460,1354],[1068,1354],[1068,1394],[460,1394]],"region":{"top_left_x":459,"top_left_y":1353,"width":609,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67cd75479930481c96c2ab5a3e82868a","type":"text","conversion_output":true,"text":"90 days is standard for current AIS trials.","text_display":" 90 days is standard for current AIS trials.","confidence":1,"confidence_rate":1},{"cnt":[[460,1439],[1381,1439],[1381,1480],[460,1480]],"region":{"top_left_x":459,"top_left_y":1439,"width":923,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28a4fc9ae3064f56b2f981d7e4a9cee7","type":"text","conversion_output":true,"text":"The study design of PRISMS has the following characteristics:","text_display":"\n\nThe study design of PRISMS has the following characteristics:","confidence":1,"confidence_rate":1},{"cnt":[[460,1495],[1663,1495],[1663,1536],[460,1536]],"region":{"top_left_x":459,"top_left_y":1495,"width":1204,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fd2bc4962a241a8bdcaf37eaf14c296","type":"text","conversion_output":true,"text":"- Consistent with the currently approved indication in the alteplase USPI:","text_display":"\n- Consistent with the currently approved indication in the alteplase USPI:","confidence":0.9990234375,"confidence_rate":0.9999876324859995},{"cnt":[[524,1538],[1704,1538],[1704,1579],[524,1579]],"region":{"top_left_x":524,"top_left_y":1538,"width":1180,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86ac11944c4840b2aa720308926ab305","type":"text","conversion_output":true,"text":"Treatment with alteplase in PRISMS will occur in otherwise eligible AIS patients","text_display":" Treatment with alteplase in PRISMS will occur in otherwise eligible AIS patients","confidence":0.9990236759185791,"confidence_rate":0.9999885082896042},{"cnt":[[524,1581],[1182,1581],[1182,1618],[524,1618]],"region":{"top_left_x":524,"top_left_y":1581,"width":658,"height":37},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87eed9bbaa244bd0bb87d5b266671d21","type":"text","conversion_output":true,"text":"within 3 hours from the last known well time.","text_display":" within 3 hours from the last known well time.","confidence":1,"confidence_rate":1},{"cnt":[[460,1637],[1747,1637],[1747,1678],[460,1678]],"region":{"top_left_x":459,"top_left_y":1637,"width":1288,"height":41},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5f73e2849744884a12f25c773e1ac78","type":"text","conversion_output":true,"text":"- Conduct of a large, multicenter study: The Sponsor plans to enroll 948 patients","text_display":"\n- Conduct of a large, multicenter study: The Sponsor plans to enroll 948 patients","confidence":1,"confidence_rate":1},{"cnt":[[524,1680],[1738,1680],[1738,1721],[524,1721]],"region":{"top_left_x":524,"top_left_y":1680,"width":1215,"height":41},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a24595ae6ea841a284ebcc4506fa8bef","type":"text","conversion_output":true,"text":"across approximately 75 sites in North America. (For comparison, the two NINDS","text_display":" across approximately 75 sites in North America. (For comparison, the two NINDS","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[524,1723],[1076,1723],[1076,1764],[524,1764]],"region":{"top_left_x":524,"top_left_y":1723,"width":553,"height":41},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cdae2503e24242988aded0120c4a9b94","type":"text","conversion_output":true,"text":"trials enrolled a total of 624 patients.)","text_display":" trials enrolled a total of 624 patients.)","confidence":1,"confidence_rate":1},{"cnt":[[460,1783],[1760,1783],[1760,1824],[460,1824]],"region":{"top_left_x":459,"top_left_y":1783,"width":1301,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1110aff1dab4187b99781a6df9ccf02","type":"text","conversion_output":true,"text":"- Multiple endpoints involving different events: In addition to the primary efficacy","text_display":"\n- Multiple endpoints involving different events: In addition to the primary 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Dosage}","confidence":1,"confidence_rate":1},{"cnt":[[460,2082],[1740,2082],[1740,2125],[460,2125]],"region":{"top_left_x":459,"top_left_y":2081,"width":1282,"height":44},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"015a05ae1c0e42c296799cface3ac7ec","type":"text","conversion_output":true,"text":"The dose selected for alteplase ( \\(0.9 mg / kg\\), maximum 90 mg ) is the approved dose for","text_display":"\n\nThe dose selected for alteplase ( \\(0.9 mg / kg\\), maximum 90 mg ) is the approved dose for","confidence":0.99853515625,"confidence_rate":0.9999859047370074},{"cnt":[[460,2127],[1760,2127],[1760,2168],[460,2168]],"region":{"top_left_x":459,"top_left_y":2126,"width":1301,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc70a423c9424cde9a3ec9c4f2cf9dca","type":"text","conversion_output":true,"text":"eligible patients with AIS in North America and is considered the standard of care by the","text_display":" eligible patients with AIS in North America and is considered the standard of care by the","confidence":0.99951171875,"confidence_rate":0.9999948042635181},{"cnt":[[460,2172],[1021,2172],[1021,2215],[460,2215]],"region":{"top_left_x":459,"top_left_y":2172,"width":562,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77b7606745ed47d2a03508b764ff4517","type":"text","conversion_output":true,"text":"stroke community (Jauch et al. 2013).","text_display":" stroke community (Jauch et al. 2013).","confidence":1,"confidence_rate":1},{"cnt":[[460,2376],[855,2376],[855,2413],[460,2413]],"region":{"top_left_x":459,"top_left_y":2376,"width":397,"height":37},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0b18b803315495c82f43c24ee19894b","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, 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be initiated within 3 hours of last known well time at","confidence":1,"confidence_rate":1},{"cnt":[[460,533],[1665,533],[1665,574],[460,574]],"region":{"top_left_x":459,"top_left_y":532,"width":1207,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c761bf435b0c40588b3eeaffe55257b5","type":"text","conversion_output":true,"text":"approximately 75 clinical sites within North America. As described in Section 1.3,","text_display":" approximately 75 clinical sites within North America. As described in Section 1.3,","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[460,578],[1721,578],[1721,621],[460,621]],"region":{"top_left_x":459,"top_left_y":577,"width":1262,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4c1b4144e0246c588b1a9c29f1cabbf","type":"text","conversion_output":true,"text":"eligible patients with mild stroke will be enrolled in this study. Currently, the alteplase","text_display":" eligible patients with mild stroke will be enrolled in this study. Currently, the alteplase","confidence":1,"confidence_rate":1},{"cnt":[[460,623],[1717,623],[1717,664],[460,664]],"region":{"top_left_x":459,"top_left_y":623,"width":1258,"height":41},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f12fac9c18949f2b6d9bcc82a46337b","type":"text","conversion_output":true,"text":"USPI warns against the use of alteplase in patients with \"minor neurologic deficit and","text_display":" USPI warns against the use of alteplase in patients with \"minor neurologic deficit and","confidence":1,"confidence_rate":1},{"cnt":[[460,666],[1571,666],[1571,711],[460,711]],"region":{"top_left_x":459,"top_left_y":666,"width":1112,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e199cf4034a847eba9ab3b26921ca14c","type":"text","conversion_output":true,"text":"rapidly improving stroke symptoms\" due to lack of data. Retrospective and","text_display":" rapidly improving stroke symptoms\" due to lack of data. Retrospective and","confidence":1,"confidence_rate":1},{"cnt":[[458,713],[1648,713],[1648,758],[458,758]],"region":{"top_left_x":457,"top_left_y":713,"width":1191,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e8f62c9be0e4b028e2177c1658ff6f3","type":"text","conversion_output":true,"text":"observational data suggest potential benefit of alteplase in these patients, with a","text_display":" observational data suggest potential benefit of alteplase in these patients, with a","confidence":1,"confidence_rate":1},{"cnt":[[458,761],[883,761],[883,801],[458,801]],"region":{"top_left_x":457,"top_left_y":760,"width":427,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fef312f23434df19b42b96e8aa39666","type":"text","conversion_output":true,"text":"favorable benefit-risk profile.","text_display":" favorable benefit-risk profile.","confidence":1,"confidence_rate":1},{"cnt":[[458,842],[1766,842],[1766,885],[458,885]],"region":{"top_left_x":457,"top_left_y":842,"width":1310,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85ffcea92872423ba1fa43e1d8f89b89","type":"text","conversion_output":true,"text":"The definition of mild stroke for PRISMS is an NIHSS score \\(\\leq 5\\) and not clearly disabling.","text_display":"\n\nThe definition of mild stroke for PRISMS is an NIHSS score \\(\\leq 5\\) and not clearly disabling.","confidence":0.9931747913360596,"confidence_rate":0.9999286628891261},{"cnt":[[460,887],[1772,887],[1772,930],[460,930]],"region":{"top_left_x":459,"top_left_y":887,"width":1314,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a01de561ceef48adac2aac8ffa17944a","type":"text","conversion_output":true,"text":"This includes patients whose symptoms are persistently mild as well as those with RISS.","text_display":" This includes patients whose symptoms are persistently mild as well as those with RISS.","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[458,971],[1669,971],[1669,1010],[458,1010]],"region":{"top_left_x":457,"top_left_y":971,"width":1213,"height":39},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67af60c1a6be445a9744551bdc00934d","type":"text","conversion_output":true,"text":"An NIHSS score \\(\\leq 5\\) was chosen as one criterion in the definition of mild stroke for","text_display":"\n\nAn NIHSS score \\(\\leq 5\\) was chosen as one criterion in the definition of mild stroke for","confidence":0.9970703125,"confidence_rate":0.9999674006709831},{"cnt":[[460,1018],[973,1018],[973,1059],[460,1059]],"region":{"top_left_x":459,"top_left_y":1018,"width":515,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e9c055df4cf4944b18261682fa29959","type":"text","conversion_output":true,"text":"PRISMS for the following reasons:","text_display":" PRISMS for the following reasons:","confidence":1,"confidence_rate":1},{"cnt":[[460,1074],[1721,1074],[1721,1119],[460,1119]],"region":{"top_left_x":459,"top_left_y":1074,"width":1262,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d452800ebfb4d55891ccdcea0e9ebf9","type":"text","conversion_output":true,"text":"1. An NIHSS score \\(\\leq 5\\) is commonly used as an exclusion criterion for many current","text_display":"\n1. An NIHSS score \\(\\leq 5\\) is commonly used as an exclusion criterion for many current","confidence":0.99853515625,"confidence_rate":0.9999833419832633},{"cnt":[[522,1117],[1742,1117],[1742,1158],[522,1158]],"region":{"top_left_x":522,"top_left_y":1117,"width":1221,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07cc72dca5ab4a548cdc551b8a3d83cc","type":"text","conversion_output":true,"text":"AIS studies, suggesting that these patients are underrepresented in current stroke","text_display":" AIS studies, suggesting that these patients are underrepresented in current stroke","confidence":1,"confidence_rate":1},{"cnt":[[524,1160],[1747,1160],[1747,1203],[524,1203]],"region":{"top_left_x":524,"top_left_y":1160,"width":1223,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf1fce97b7094626849929020a590d12","type":"text","conversion_output":true,"text":"research and are treated differently by the stroke community, as shown in Table 2.","text_display":" research and are treated differently by the stroke community, as shown in Table 2.","confidence":1,"confidence_rate":1},{"cnt":[[458,1212],[1747,1212],[1747,1261],[458,1261]],"region":{"top_left_x":457,"top_left_y":1211,"width":1290,"height":51},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe26050b4b224079a0347004bb9a33b8","type":"text","conversion_output":true,"text":"2. The largest retrospective analysis of mild stroke from the Get With the Guidelines \\({ }^{\\text {® }}\\)","text_display":"\n2. 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This definition of RISS is consistent with a recent consensus","text_display":" withholding therapy. 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These clearly disabling deficits at presentation may include, but are not","text_display":" clearly disabled. 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Patients with clearly disabling deficits will be","text_display":" hemineglect, or cortical blindness. Patients with clearly disabling deficits will be","confidence":1,"confidence_rate":1},{"cnt":[[458,971],[1721,971],[1721,1016],[458,1016]],"region":{"top_left_x":457,"top_left_y":971,"width":1264,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"834e1449161b4caba36c188689bad2f4","type":"text","conversion_output":true,"text":"excluded from this study irrespective of the NIHSS score at time of randomization, as","text_display":" excluded from this study irrespective of the NIHSS score at time of randomization, as","confidence":1,"confidence_rate":1},{"cnt":[[460,1018],[1740,1018],[1740,1061],[460,1061]],"region":{"top_left_x":459,"top_left_y":1018,"width":1282,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ef6d902345c4eccb08d9a5d1b1de265","type":"text","conversion_output":true,"text":"current clinical practice and ethical responsibility suggest that these patients should be","text_display":" current clinical practice and ethical responsibility suggest that these patients should be","confidence":1,"confidence_rate":1},{"cnt":[[458,1061],[1762,1061],[1762,1106],[458,1106]],"region":{"top_left_x":457,"top_left_y":1061,"width":1305,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2aa8657d98194155b37044a869b5ca41","type":"text","conversion_output":true,"text":"evaluated to receive alteplase rather than be enrolled in a randomized study where they","text_display":" evaluated to receive alteplase rather than be enrolled in a randomized study where they","confidence":1,"confidence_rate":1},{"cnt":[[460,1109],[922,1109],[922,1154],[460,1154]],"region":{"top_left_x":459,"top_left_y":1108,"width":463,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fde7971c2844832acb68ec26ff49bef","type":"text","conversion_output":true,"text":"may receive alteplase placebo.","text_display":" may receive alteplase placebo.","confidence":1,"confidence_rate":1},{"cnt":[[453,1182],[1167,1182],[1167,1235],[453,1235]],"region":{"top_left_x":453,"top_left_y":1181,"width":714,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4094631eefad4dc9a6141c81f5c2b49e","type":"section_header","conversion_output":false,"children_ids":["420c54e43d274846b45d79c9048e34b1"],"text":"","text_display":""},{"cnt":[[460,1186],[1162,1186],[1162,1231],[460,1231]],"region":{"top_left_x":459,"top_left_y":1185,"width":704,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"420c54e43d274846b45d79c9048e34b1","type":"text","conversion_output":true,"parent_id":"4094631eefad4dc9a6141c81f5c2b49e","text":"3.4.3 Rationale for Control Group","text_display":"\n\n\\subsection*{3.4.3 Rationale for Control Group}","confidence":0.99951171875,"confidence_rate":0.9999871474379078},{"cnt":[[458,1242],[1626,1242],[1626,1285],[458,1285]],"region":{"top_left_x":457,"top_left_y":1241,"width":1170,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5491a3db9a0c419b8172f7db52527e9b","type":"text","conversion_output":true,"text":"The overall rationale for this trial is to determine whether IV alteplase improves","text_display":"\n\nThe overall rationale for this trial is to determine whether IV alteplase improves","confidence":1,"confidence_rate":1},{"cnt":[[458,1289],[1742,1289],[1742,1334],[458,1334]],"region":{"top_left_x":457,"top_left_y":1289,"width":1286,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50688af7f2b34cc9b2cba2c277b0924c","type":"text","conversion_output":true,"text":"outcomes in patients with mild stroke. The control group (i.e., mild stroke patients who","text_display":" outcomes in patients with mild stroke. The control group (i.e., mild stroke patients who","confidence":1,"confidence_rate":1},{"cnt":[[458,1334],[1721,1334],[1721,1377],[458,1377]],"region":{"top_left_x":457,"top_left_y":1334,"width":1264,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"897a486167754b409e969765805f7aa7","type":"text","conversion_output":true,"text":"receive standard of care) has been included so that outcomes in the active treatment","text_display":" receive standard of care) has been included so that outcomes in the active treatment","confidence":1,"confidence_rate":1},{"cnt":[[458,1379],[1729,1379],[1729,1424],[458,1424]],"region":{"top_left_x":457,"top_left_y":1379,"width":1273,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ea696e14bb74f7b939242ad70ed928a","type":"text","conversion_output":true,"text":"group can be compared to those who receive standard of care. The control group will","text_display":" group can be compared to those who receive standard of care. The control group will","confidence":0.99755859375,"confidence_rate":0.9999722232114437},{"cnt":[[458,1422],[1714,1422],[1714,1467],[458,1467]],"region":{"top_left_x":457,"top_left_y":1422,"width":1258,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d0c66a24da745dbbef34450f929cd00","type":"text","conversion_output":true,"text":"receive IV alteplase placebo and 325 mg of oral aspirin. The rationale for the control","text_display":" receive IV alteplase placebo and 325 mg of oral aspirin. The rationale for the control","confidence":1,"confidence_rate":1},{"cnt":[[458,1470],[1712,1470],[1712,1515],[458,1515]],"region":{"top_left_x":457,"top_left_y":1469,"width":1256,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ad5d1df88694bc9ace973dc62b0b4b2","type":"text","conversion_output":true,"text":"group receiving aspirin is that it would be unethical to withhold a dose of aspirin from","text_display":" group receiving aspirin is that it would be unethical to withhold a dose of aspirin from","confidence":1,"confidence_rate":1},{"cnt":[[458,1517],[1766,1517],[1766,1560],[458,1560]],"region":{"top_left_x":457,"top_left_y":1516,"width":1310,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c111413578b34d74a5d5912e5941edad","type":"text","conversion_output":true,"text":"patients who would not be receiving active study drug. The standard of care for patients","text_display":" patients who would not be receiving active study drug. The standard of care for patients","confidence":1,"confidence_rate":1},{"cnt":[[458,1560],[1760,1560],[1760,1605],[458,1605]],"region":{"top_left_x":457,"top_left_y":1559,"width":1303,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5a4902751284003b9e34f078b77bd01","type":"text","conversion_output":true,"text":"suffering from AIS who are ineligible for IV alteplase therapy is oral aspirin administered","text_display":" suffering from AIS who are ineligible for IV alteplase therapy is oral aspirin administered","confidence":1,"confidence_rate":1},{"cnt":[[455,1607],[1412,1607],[1412,1652],[455,1652]],"region":{"top_left_x":455,"top_left_y":1607,"width":957,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d73eed5227c8421485bd230b2b6c7fd5","type":"text","conversion_output":true,"text":"within the first 24 hours after the onset of their stroke symptoms.","text_display":" within the first 24 hours after the onset of their stroke symptoms.","confidence":1,"confidence_rate":1},{"cnt":[[455,1678],[1085,1678],[1085,1725],[455,1725]],"region":{"top_left_x":455,"top_left_y":1677,"width":630,"height":49},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2662cd32b93149378b781d32dd9267d0","type":"section_header","conversion_output":false,"children_ids":["12657449b6454c5890ef42a1624db33a"],"text":"","text_display":""},{"cnt":[[460,1684],[1081,1684],[1081,1721],[460,1721]],"region":{"top_left_x":459,"top_left_y":1684,"width":622,"height":37},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12657449b6454c5890ef42a1624db33a","type":"text","conversion_output":true,"parent_id":"2662cd32b93149378b781d32dd9267d0","text":"3.5 OUTCOME MEASURES","text_display":"\n\n\\subsection*{3.5 OUTCOME MEASURES}","confidence":1,"confidence_rate":1},{"cnt":[[453,1732],[1171,1732],[1171,1790],[453,1790]],"region":{"top_left_x":453,"top_left_y":1731,"width":718,"height":59},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57795d43ad9f421d8af77414fe51f11d","type":"section_header","conversion_output":false,"children_ids":["5391a4e1fdbd4ad49acf6c6ba5e5d0fd"],"text":"","text_display":""},{"cnt":[[460,1740],[1167,1740],[1167,1785],[460,1785]],"region":{"top_left_x":459,"top_left_y":1740,"width":708,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5391a4e1fdbd4ad49acf6c6ba5e5d0fd","type":"text","conversion_output":true,"parent_id":"57795d43ad9f421d8af77414fe51f11d","text":"3.5.1 Efficacy Outcome Measures","text_display":"\n\n\\subsection*{3.5.1 Efficacy Outcome Measures}","confidence":0.99951171875,"confidence_rate":0.9999864334115239},{"cnt":[[458,1796],[1283,1796],[1283,1841],[458,1841]],"region":{"top_left_x":457,"top_left_y":1796,"width":826,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91dde0a1ab934b96a3ff30aa83aeb32b","type":"text","conversion_output":true,"text":"The primary efficacy outcome measure for this study is:","text_display":"\n\nThe primary efficacy outcome measure for this study is:","confidence":1,"confidence_rate":1},{"cnt":[[458,1852],[1669,1852],[1669,1897],[458,1897]],"region":{"top_left_x":457,"top_left_y":1851,"width":1213,"height":47},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f02c3c9711614a00bf232bcdbf60250f","type":"text","conversion_output":true,"text":"- A favorable functional outcome, defined by an mRS score of 0 or 1 at Day 90","text_display":"\n- A favorable functional outcome, defined by an mRS score of 0 or 1 at Day 90","confidence":0.9653487205505371,"confidence_rate":0.9996208689370096},{"cnt":[[524,1899],[816,1899],[816,1940],[524,1940]],"region":{"top_left_x":524,"top_left_y":1899,"width":293,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6134b9359d9431880014ecf176849b3","type":"text","conversion_output":true,"text":"post-randomization","text_display":" post-randomization","confidence":1,"confidence_rate":1},{"cnt":[[520,1955],[1665,1955],[1665,1996],[520,1996]],"region":{"top_left_x":519,"top_left_y":1955,"width":1147,"height":41},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d20d8891daff4a24a51fe2cf32c9362d","type":"text","conversion_output":true,"text":"- All mRS assessments will be made by investigators blinded to treatment","text_display":"\n- All mRS assessments will be made by investigators blinded to 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measured at Day 90 and listed below:","confidence":1,"confidence_rate":1},{"cnt":[[460,2133],[724,2133],[724,2172],[460,2172]],"region":{"top_left_x":459,"top_left_y":2133,"width":266,"height":40},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d231b105dec74fa38ffe485904b3220c","type":"text","conversion_output":true,"text":"- Ordinal mRS","text_display":"\n- Ordinal mRS","confidence":1,"confidence_rate":1},{"cnt":[[460,2191],[1674,2191],[1674,2237],[460,2237]],"region":{"top_left_x":459,"top_left_y":2191,"width":1215,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69ff0adea5c34f2298c6bf83af847363","type":"text","conversion_output":true,"text":"- Global favorable recovery (Global Outcome Measure derived from mRS 0-1,","text_display":"\n- Global favorable recovery (Global Outcome Measure derived from mRS 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Inc.","text_display":"","confidence":0.9922086952815334,"confidence_rate":0.9998796716167225},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9de7e8c1962468bacf07ae68e9fbe90","type":"page_info","conversion_output":false,"text":"575/aCSR 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New ICH seen on imaging will be later confirmed on","text_display":" imaging by the investigator. New ICH seen on imaging will be later confirmed on","confidence":1,"confidence_rate":1},{"cnt":[[567,640],[1424,640],[1424,683],[567,683]],"region":{"top_left_x":567,"top_left_y":640,"width":858,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab602bdeca094f57bee4bd49da6926e5","type":"text","conversion_output":true,"text":"independent reading by blinded central study radiologists.","text_display":" independent reading by blinded central study radiologists.","confidence":1,"confidence_rate":1},{"cnt":[[460,700],[887,700],[887,741],[460,741]],"region":{"top_left_x":459,"top_left_y":700,"width":429,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e9e07f257724911b8ae529b2e248a12","type":"text","conversion_output":true,"text":"- Any ICH within 36 hours","text_display":"\n- Any ICH within 36 hours","confidence":1,"confidence_rate":1},{"cnt":[[460,756],[993,756],[993,797],[460,797]],"region":{"top_left_x":459,"top_left_y":756,"width":534,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b9526c6167f4cf5893cfa6ce7560a68","type":"text","conversion_output":true,"text":"- Overall mortality within 90 days","text_display":"\n- Overall mortality within 90 days","confidence":1,"confidence_rate":1},{"cnt":[[460,812],[1326,810],[1326,855],[460,857]],"region":{"top_left_x":459,"top_left_y":810,"width":867,"height":48},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20eb533df4fa4776a0d5f42cf7aced3c","type":"text","conversion_output":true,"text":"- Stroke-related and neurological deaths within 90 days","text_display":"\n- Stroke-related and neurological deaths within 90 days","confidence":1,"confidence_rate":1},{"cnt":[[460,872],[1334,872],[1334,913],[460,913]],"region":{"top_left_x":459,"top_left_y":872,"width":876,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"624696548aea49b7a916b14a43a502df","type":"text","conversion_output":true,"text":"- Incidence, severity, and spectrum of all AEs and SAEs","text_display":"\n- Incidence, severity, and spectrum of all AEs and SAEs","confidence":1,"confidence_rate":1},{"cnt":[[455,939],[1128,939],[1128,990],[455,990]],"region":{"top_left_x":455,"top_left_y":938,"width":673,"height":53},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f314407b8bf548a389ba9f97cedf4236","type":"section_header","conversion_output":false,"children_ids":["0cc86ada1d504b6491b97485dc3f879f"],"text":"","text_display":""},{"cnt":[[460,941],[1124,941],[1124,986],[460,986]],"region":{"top_left_x":459,"top_left_y":941,"width":665,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cc86ada1d504b6491b97485dc3f879f","type":"text","conversion_output":true,"parent_id":"f314407b8bf548a389ba9f97cedf4236","text":"Symptomatic Intracranial Hemorrhage","text_display":"\n\n\\section*{Symptomatic Intracranial Hemorrhage}","confidence":1,"confidence_rate":1},{"cnt":[[460,993],[1592,993],[1592,1033],[460,1033]],"region":{"top_left_x":459,"top_left_y":992,"width":1133,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de4779ceaa5143fb8174d8dca0f1817c","type":"text","conversion_output":true,"text":"In this study, an ICH is considered symptomatic if it is not seen on computed","text_display":"\n\nIn this study, an ICH is considered symptomatic if it is not seen on computed","confidence":1,"confidence_rate":1},{"cnt":[[460,1036],[1669,1036],[1669,1081],[460,1081]],"region":{"top_left_x":459,"top_left_y":1035,"width":1211,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c056836fe5d14eb29e7c86a7614844fd","type":"text","conversion_output":true,"text":"tomography (CT) or magnetic resonance imaging (MRI) scan at baseline and any","text_display":" tomography (CT) or magnetic resonance imaging (MRI) scan at baseline and any","confidence":1,"confidence_rate":1},{"cnt":[[460,1083],[1678,1083],[1678,1126],[460,1126]],"region":{"top_left_x":459,"top_left_y":1082,"width":1219,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f428bbf300ae4516b439ab094d44f823","type":"text","conversion_output":true,"text":"neurologic decline is attributed to it by the local investigator. To detect intracranial","text_display":" neurologic decline is attributed to it by the local investigator. To detect intracranial","confidence":1,"confidence_rate":1},{"cnt":[[460,1128],[1732,1128],[1732,1171],[460,1171]],"region":{"top_left_x":459,"top_left_y":1127,"width":1273,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f374f007b0404d0fad645b96c6e1533f","type":"text","conversion_output":true,"text":"hemorrhage, neuroimaging (CT or MRI) scan is required at 22 to 36 hours. Additional","text_display":" hemorrhage, neuroimaging (CT or MRI) scan is required at 22 to 36 hours. Additional","confidence":1,"confidence_rate":1},{"cnt":[[460,1173],[1714,1173],[1714,1218],[460,1218]],"region":{"top_left_x":459,"top_left_y":1173,"width":1256,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c9cfa11687148909729161b4d4d8b49","type":"text","conversion_output":true,"text":"neuroimaging should be performed at any time based on the investigator's discretion","text_display":" neuroimaging should be performed at any time based on the investigator's discretion","confidence":1,"confidence_rate":1},{"cnt":[[458,1220],[1680,1220],[1680,1261],[458,1261]],"region":{"top_left_x":457,"top_left_y":1220,"width":1224,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f4b8f4ff4fe4d1ea92a90e5aa355249","type":"text","conversion_output":true,"text":"that clinical findings suggested hemorrhage. Details on MRI types are described in","text_display":" that clinical findings suggested hemorrhage. Details on MRI types are described in","confidence":1,"confidence_rate":1},{"cnt":[[460,1265],[698,1265],[698,1304],[460,1304]],"region":{"top_left_x":459,"top_left_y":1265,"width":240,"height":40},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e32e4cf75a0549b3ac1ab299490287d3","type":"text","conversion_output":true,"text":"Section 4.5.1.6.","text_display":" Section 4.5.1.6.","confidence":1,"confidence_rate":1},{"cnt":[[460,1349],[1734,1349],[1734,1390],[460,1390]],"region":{"top_left_x":459,"top_left_y":1349,"width":1275,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0ac2da0b2e0439bbbe9b1ef219a2da6","type":"text","conversion_output":true,"text":"Intracranial hemorrhage events will include classifications of intracerebral hemorrhage","text_display":"\n\nIntracranial hemorrhage events will include classifications of intracerebral hemorrhage","confidence":0.970703125,"confidence_rate":0.9996768500617699},{"cnt":[[460,1394],[1669,1394],[1669,1437],[460,1437]],"region":{"top_left_x":459,"top_left_y":1394,"width":1211,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28402473e85c4fb98691204853b50ccf","type":"text","conversion_output":true,"text":"(hemorrhagic infarct type 1 or type 2, parenchymal hematoma type 1 or type 2, or","text_display":" (hemorrhagic infarct type 1 or type 2, parenchymal hematoma type 1 or type 2, or","confidence":0.9281541055224807,"confidence_rate":0.9991810223805807},{"cnt":[[460,1439],[1717,1439],[1717,1482],[460,1482]],"region":{"top_left_x":459,"top_left_y":1439,"width":1258,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ea77b969b2b4f03b14832a05b8d9f33","type":"text","conversion_output":true,"text":"remote intraparenchymal hemorrhage type 1 or type 2). Descriptions of each type of","text_display":" remote intraparenchymal hemorrhage type 1 or type 2). Descriptions of each type of","confidence":0.7048773765563965,"confidence_rate":0.9961216356324485},{"cnt":[[460,1482],[1691,1482],[1691,1528],[460,1528]],"region":{"top_left_x":459,"top_left_y":1482,"width":1232,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1925aa384d8c4f06b1d17f46016ce501","type":"text","conversion_output":true,"text":"intracerebral hemorrhage are shown in the table below. Additionally, subarachnoid","text_display":" intracerebral hemorrhage are shown in the table below. Additionally, subarachnoid","confidence":1,"confidence_rate":1},{"cnt":[[460,1530],[1601,1530],[1601,1573],[460,1573]],"region":{"top_left_x":459,"top_left_y":1529,"width":1142,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6d4df9d1d8b4737985a3a84ccee16ab","type":"text","conversion_output":true,"text":"hemorrhage, subdural hemorrhage, or epidural hemorrhage should be noted.","text_display":" hemorrhage, subdural hemorrhage, or epidural hemorrhage should be noted.","confidence":1,"confidence_rate":1},{"cnt":[[455,1605],[1285,1605],[1285,1654],[455,1654]],"region":{"top_left_x":455,"top_left_y":1604,"width":830,"height":51},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57ec2d86dfd042eb936e948d4c299536","type":"figure_label","conversion_output":false,"text":"Table 3 Intracerebral Hemorrhage Definitions","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999906077268363},{"cnt":[[458,1667],[1777,1667],[1777,2262],[458,2262]],"region":{"top_left_x":457,"top_left_y":1667,"width":1320,"height":596},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c49485255e4f4baca688de44fdb420fd","type":"table","conversion_output":true,"children_ids":["6b3295e867c54d68b12f41f83740e4b9","c6ded5a11dae4c87ad085c0152ad0f0e","4f6adb50fcf949959cf3fe1b1580f0cd","49f0c02887da4e8b9198109fa04fd513","d09545b1aac744a1b89b39f375e2a6c4","a910aa35070840b3ac0de0dab3e90c90","db5e72822d51403c82f0d0c360dabbb9","2ba52f8b6fbe4261aaaf5887826becf1","c3c12be1a5114df9a3d29378c8f87315","d68c09e88d79443284170c5f92ec959b","f93efd358bdd4f468c919ebca04f0c4c","63bf4b352999412295e8912f5b04c8cc","4ff4767bf968426492a93e3b22790510","a088aefd3fa2446aabbad8ab58335a10","b7ddadc03c42471692416bca40a0491d","bc544aa2a5ed4a18b253f470e4823eb3","47831c1226544cc3b14de7c61a674edd","176af4b3a06d40a190db8d6dce32c0eb","4852b64423d244ff9b6b8b83006b71a9","88a72eb517c848ed9bcd2ff9b39c6206","f748d3a1ba7341a3b3c75e46c5d932e4","27969c165fe245d5839327c5dd4c02e9","d2687350f12d4afaa1c6cfbf600bcaed"],"selected_labels":["57ec2d86dfd042eb936e948d4c299536"],"text":"\\begin{tabular}{|l|l|}\n\\hline Type & Description \\\\\n\\hline HI type 1 & Small petechiae along margin of infarct \\\\\n\\hline HI type 2 & More confluent petechiae within the infarcted area but without spaceoccupying effect \\\\\n\\hline PH type 1 & Hematoma in \\(\\leq 30 \\%\\) of the infarcted area with some slight space-occupying effect \\\\\n\\hline PH type 2 & Dense hematoma \\(>30 \\%\\) total of the infarcted area with substantial spaceoccupying effect or any hemorrhagic area outside the infarcted area \\\\\n\\hline rPH type 1 & Small or medium sized blood clots located remote from the actual infarct; a mild space-occupying effect could be present. Remote primary intracerebral hemorrhage \\\\\n\\hline rPH type 2 & Large confluent dense blood clots in an area remote from the actual infarct; substantial space-occupying effect might be present. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3 Intracerebral Hemorrhage Definitions}\n\\begin{tabular}{|l|l|}\n\\hline Type & Description \\\\\n\\hline HI type 1 & Small petechiae along margin of infarct \\\\\n\\hline HI type 2 & More confluent petechiae within the infarcted area but without spaceoccupying effect \\\\\n\\hline PH type 1 & Hematoma in \\(\\leq 30 \\%\\) of the infarcted area with some slight space-occupying effect \\\\\n\\hline PH type 2 & Dense hematoma \\(>30 \\%\\) total of the infarcted area with substantial spaceoccupying effect or any hemorrhagic area outside the infarcted area \\\\\n\\hline rPH type 1 & Small or medium sized blood clots located remote from the actual infarct; a mild space-occupying effect could be present. Remote primary intracerebral hemorrhage \\\\\n\\hline rPH type 2 & Large confluent dense blood clots in an area remote from the actual infarct; substantial space-occupying effect might be present. 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Pre-mixing may","confidence":1,"confidence_rate":1},{"cnt":[[460,1710],[1687,1710],[1687,1751],[460,1751]],"region":{"top_left_x":459,"top_left_y":1710,"width":1228,"height":41},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a8e8f347e104edc9be318fa7ee8da5e","type":"text","conversion_output":true,"text":"occur prior to signing informed consent but should be performed after key eligibility","text_display":" occur prior to signing informed consent but should be performed after key eligibility","confidence":1,"confidence_rate":1},{"cnt":[[460,1757],[1721,1757],[1721,1798],[460,1798]],"region":{"top_left_x":459,"top_left_y":1757,"width":1262,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08694ffc14e44bc699ef77f9b9d3b79e","type":"text","conversion_output":true,"text":"criteria (e.g., NIHSS \\(\\leq 5\\) and not clearly disabling, study drug initiation will occur within","text_display":" criteria (e.g., NIHSS \\(\\leq 5\\) and not clearly disabling, study drug initiation will occur within","confidence":1,"confidence_rate":1},{"cnt":[[460,1800],[1710,1800],[1710,1841],[460,1841]],"region":{"top_left_x":459,"top_left_y":1800,"width":1252,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bb471434ccf4a95b56bd8773def54e0","type":"text","conversion_output":true,"text":"3 hours of time last known well, CT/MRI negative for ICH) to minimize drug wastage.","text_display":" 3 hours of time last known well, CT/MRI negative for ICH) to minimize drug wastage.","confidence":1,"confidence_rate":1},{"cnt":[[460,1848],[1772,1848],[1772,1888],[460,1888]],"region":{"top_left_x":459,"top_left_y":1847,"width":1314,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"795d38d9b8f341829589ba918bce05bc","type":"text","conversion_output":true,"text":"Study drug bolus will be administered after confirming that all eligibility criteria have been","text_display":" Study drug bolus will be administered after confirming that all eligibility criteria have been","confidence":1,"confidence_rate":1},{"cnt":[[460,1895],[1682,1895],[1682,1934],[460,1934]],"region":{"top_left_x":459,"top_left_y":1894,"width":1224,"height":40},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56d6861ccc3944df810fe3f97882ddd6","type":"text","conversion_output":true,"text":"met and informed consent signed, and this will indicate enrollment in the trial. 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Following study drug administration","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[460,1985],[1678,1985],[1678,2026],[460,2026]],"region":{"top_left_x":459,"top_left_y":1985,"width":1219,"height":41},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c594183945f14fb491ba3a9377e1254d","type":"text","conversion_output":true,"text":"(within 8 hours), the study site should enter the patient's ID, including date of birth,","text_display":" (within 8 hours), the study site should enter the patient's ID, including date of birth,","confidence":1,"confidence_rate":1},{"cnt":[[460,2030],[1764,2030],[1764,2071],[460,2071]],"region":{"top_left_x":459,"top_left_y":2030,"width":1305,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"553ccb132dda41c7a9fd56e7d8446323","type":"text","conversion_output":true,"text":"patient initials, screening ID, and confirm drug kit IDs from the kits with which the patient","text_display":" patient initials, screening ID, and confirm drug kit IDs from the kits with which the patient","confidence":1,"confidence_rate":1},{"cnt":[[460,2075],[1661,2075],[1661,2112],[460,2112]],"region":{"top_left_x":459,"top_left_y":2075,"width":1202,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c06aece7696f4798a6f2b737f4ba1f53","type":"text","conversion_output":true,"text":"is treated. Once this information is entered into IWRS, it will result in two actions:","text_display":" is treated. Once this information is entered into IWRS, it will result in two actions:","confidence":1,"confidence_rate":1},{"cnt":[[460,2133],[1772,2133],[1772,2172],[460,2172]],"region":{"top_left_x":459,"top_left_y":2133,"width":1314,"height":40},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e7f8268da8644edaffb8bcd1965b0e7","type":"text","conversion_output":true,"text":"1. IWRS will assign a patient ID to the currently treated patient, which will be correlated","text_display":"\n1. IWRS will assign a patient ID to the currently treated patient, which will be correlated","confidence":0.9677734375,"confidence_rate":0.9996588366337373},{"cnt":[[524,2174],[1781,2174],[1781,2215],[524,2215]],"region":{"top_left_x":524,"top_left_y":2174,"width":1258,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a23aa6635c964dc185766b0fb64a5150","type":"text","conversion_output":true,"text":"to the drug kit ID previously labeled as \"Use Next,\" via the randomization visit record.","text_display":" to the drug kit ID previously labeled as \"Use Next,\" via the randomization visit record.","confidence":1,"confidence_rate":1},{"cnt":[[460,2234],[1764,2234],[1764,2275],[460,2275]],"region":{"top_left_x":459,"top_left_y":2234,"width":1305,"height":42},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"490f7c3ab5764badaa8f50de9fb6f2c1","type":"text","conversion_output":true,"text":"2. IWRS will assign a new pair of drug kit IDs for the next patient that becomes eligible","text_display":"\n2. IWRS will assign a new pair of drug kit IDs for the next patient that becomes eligible","confidence":1,"confidence_rate":1},{"cnt":[[524,2277],[1106,2277],[1106,2310],[524,2310]],"region":{"top_left_x":524,"top_left_y":2277,"width":583,"height":33},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"180d85a736c04312a357aa49cdf1ed38","type":"text","conversion_output":true,"text":"at that site to be labeled as \"Use Next.\"","text_display":" at that site to be labeled as \"Use Next.\"","confidence":1,"confidence_rate":1},{"cnt":[[458,2376],[857,2376],[857,2415],[458,2415]],"region":{"top_left_x":457,"top_left_y":2376,"width":401,"height":39},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bdb164d12237416f8565e2b6b4e4bbfe","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9926931707926769,"confidence_rate":0.9997555747154862},{"cnt":[[460,2413],[896,2413],[896,2447],[460,2447]],"region":{"top_left_x":459,"top_left_y":2412,"width":437,"height":36},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aceb437b6ddc4237afb663fd37a1d7ec","type":"page_info","conversion_output":false,"text":"34/Protocol ML29093, Version 3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[372,2574],[1416,2574],[1416,2615],[372,2615]],"region":{"top_left_x":371,"top_left_y":2573,"width":1045,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84c20b96c5da441fb9e890a2ddc9eafc","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922089320737632,"confidence_rate":0.9998796752878439},{"cnt":[[374,2608],[692,2608],[692,2640],[374,2640]],"region":{"top_left_x":373,"top_left_y":2608,"width":319,"height":33},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"751e8ad338ce43eea48f0413207a0156","type":"page_info","conversion_output":false,"text":"579/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-244","page":244,"lines":[{"cnt":[[460,391],[1652,391],[1652,432],[460,432]],"region":{"top_left_x":459,"top_left_y":391,"width":1194,"height":41},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f71b7cd5532d4476a2361d0c0c530b4e","type":"text","conversion_output":true,"text":"In the case when pre-mixed IV drug is not used (e.g., patient is determined to be","text_display":"\n\nIn the case when pre-mixed IV drug is not used (e.g., patient is determined to be","confidence":1,"confidence_rate":1},{"cnt":[[460,434],[1729,434],[1729,477],[460,477]],"region":{"top_left_x":459,"top_left_y":433,"width":1271,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08407da89e1d45868302f73f5a00bc3f","type":"text","conversion_output":true,"text":"ineligible for study or declines informed consent prior to drug administration), sites will","text_display":" ineligible for study or declines informed consent prior to drug administration), sites will","confidence":1,"confidence_rate":1},{"cnt":[[460,481],[1712,481],[1712,522],[460,522]],"region":{"top_left_x":459,"top_left_y":481,"width":1254,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12c536d7d46044c78a2dcd098e388931","type":"text","conversion_output":true,"text":"enter drug kit IDs into IWRS and indicate that the kits were not used. IWRS will then","text_display":" enter drug kit IDs into IWRS and indicate that the kits were not used. IWRS will then","confidence":0.9931640625,"confidence_rate":0.9999237872426632},{"cnt":[[460,524],[1742,524],[1742,569],[460,569]],"region":{"top_left_x":459,"top_left_y":524,"width":1284,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"506f56f2a43b494dbc82d75e62087c1d","type":"text","conversion_output":true,"text":"assign a new set of drug kit IDs for the pharmacist to label with \"Use Next\" labels. The","text_display":" assign a new set of drug kit IDs for the pharmacist to label with \"Use Next\" labels. 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Unblinding should occur only in settings where identification of","text_display":" the intended unblinding. Unblinding should occur only in settings where identification of","confidence":1,"confidence_rate":1},{"cnt":[[458,1053],[1637,1053],[1637,1094],[458,1094]],"region":{"top_left_x":457,"top_left_y":1052,"width":1181,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c03e7eb20bb4808a1088e294474a10e","type":"text","conversion_output":true,"text":"the study treatment is critical for treatment decisions. IWRS will be used for the","text_display":" the study treatment is critical for treatment decisions. 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All unblinded patients will remain in the study and require all","confidence":1,"confidence_rate":1},{"cnt":[[458,1143],[690,1143],[690,1188],[458,1188]],"region":{"top_left_x":457,"top_left_y":1142,"width":233,"height":47},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"373c4b4fb05141b4b02461928be044d8","type":"text","conversion_output":true,"text":"follow-up visits.","text_display":" follow-up visits.","confidence":1,"confidence_rate":1},{"cnt":[[460,1229],[1755,1229],[1755,1270],[460,1270]],"region":{"top_left_x":459,"top_left_y":1228,"width":1297,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fcfee73ebecc47fe8be1ce18c0b65b18","type":"text","conversion_output":true,"text":"Treatment codes should not be broken except under circumstances deemed necessary","text_display":"\n\nTreatment codes should not be broken except under circumstances deemed necessary","confidence":1,"confidence_rate":1},{"cnt":[[460,1272],[1738,1272],[1738,1315],[460,1315]],"region":{"top_left_x":459,"top_left_y":1271,"width":1280,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da95dd6bd6b247dcb6511d8641a32906","type":"text","conversion_output":true,"text":"by the site investigator. 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Each kit will contain one bottle, which","text_display":"\n\nAspirin \\((325 mg )\\) will be packaged for the study. Each kit will contain one bottle, which","confidence":0.609375,"confidence_rate":0.9949584511039449},{"cnt":[[455,1375],[1742,1375],[1742,1420],[455,1420]],"region":{"top_left_x":455,"top_left_y":1375,"width":1288,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be78cc40d1cf427c9928c2035292ac8a","type":"text","conversion_output":true,"text":"has 100 tablets labeled for \"clinical trial use only.\" Only one tablet will be administered","text_display":" has 100 tablets labeled for \"clinical trial use only.\" Only one tablet will be administered","confidence":1,"confidence_rate":1},{"cnt":[[455,1422],[1588,1422],[1588,1467],[455,1467]],"region":{"top_left_x":455,"top_left_y":1422,"width":1133,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e5c7c85d8714d40b0b86c7d20aa0bb2","type":"text","conversion_output":true,"text":"to the patient, and the remainder of the bottle will be kept at the site for drug","text_display":" to the patient, and the remainder of the bottle will be kept at the site for drug","confidence":1,"confidence_rate":1},{"cnt":[[458,1465],[677,1465],[677,1510],[458,1510]],"region":{"top_left_x":457,"top_left_y":1465,"width":220,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0eef5a419654ebaac4188fcd1b49221","type":"text","conversion_output":true,"text":"accountability.","text_display":" accountability.","confidence":1,"confidence_rate":1},{"cnt":[[455,1549],[1760,1549],[1760,1592],[455,1592]],"region":{"top_left_x":455,"top_left_y":1549,"width":1305,"height":43},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22f329863d564cce9ef61c6da9b4a2b2","type":"text","conversion_output":true,"text":"Aspirin tablets should be stored at \\(25^{\\circ} C\\) with excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","text_display":"\n\nAspirin tablets should be stored at \\(25^{\\circ} C\\) with excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","confidence":0.99951171875,"confidence_rate":0.9999961543341811},{"cnt":[[449,1616],[965,1616],[965,1678],[449,1678]],"region":{"top_left_x":449,"top_left_y":1615,"width":516,"height":63},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94929ad93c1f47e5b79999f2c4a0ab52","type":"section_header","conversion_output":false,"children_ids":["f9d108f5dc684bb7891df8b08a2f8287"],"text":"","text_display":""},{"cnt":[[455,1624],[956,1624],[956,1671],[455,1671]],"region":{"top_left_x":455,"top_left_y":1624,"width":502,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9d108f5dc684bb7891df8b08a2f8287","type":"text","conversion_output":true,"parent_id":"94929ad93c1f47e5b79999f2c4a0ab52","text":"4.3.1.4 Aspirin Placebo","text_display":"\n\n\\subsection*{4.3.1.4 Aspirin Placebo}","confidence":0.9980478286743164,"confidence_rate":0.9999302138888906},{"cnt":[[455,1676],[1717,1676],[1717,1721],[455,1721]],"region":{"top_left_x":455,"top_left_y":1675,"width":1262,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54456aedbe9b4f88aa039328084731f5","type":"text","conversion_output":true,"text":"Aspirin placebo will be identical in appearance to active aspirin to maintain treatment","text_display":"\n\nAspirin placebo will be identical in appearance to active aspirin to maintain treatment","confidence":1,"confidence_rate":1},{"cnt":[[458,1719],[1766,1719],[1766,1766],[458,1766]],"region":{"top_left_x":457,"top_left_y":1718,"width":1310,"height":49},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3cfb53e3ea34e4c90ab7cc7aa3320a1","type":"text","conversion_output":true,"text":"blinding. Each bottle of aspirin placebo contains 100 tablets labeled for \"clinical trial use","text_display":" blinding. Each bottle of aspirin placebo contains 100 tablets labeled for \"clinical trial use","confidence":0.998046875,"confidence_rate":0.9999806434067887},{"cnt":[[458,1766],[1772,1766],[1772,1811],[458,1811]],"region":{"top_left_x":457,"top_left_y":1766,"width":1316,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be3dfe25bc7a421f93a9d05d19fe6d98","type":"text","conversion_output":true,"text":"only.\" Only one tablet will be administered to the patient, and the remainder of the bottle","text_display":" only.\" Only one tablet will be administered to the patient, and the remainder of the bottle","confidence":1,"confidence_rate":1},{"cnt":[[455,1811],[1132,1811],[1132,1858],[455,1858]],"region":{"top_left_x":455,"top_left_y":1811,"width":678,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7397912dea5c40b185cd221c76be5e27","type":"text","conversion_output":true,"text":"will be kept at the site for drug accountability.","text_display":" will be kept at the site for drug accountability.","confidence":1,"confidence_rate":1},{"cnt":[[458,1895],[1687,1895],[1687,1940],[458,1940]],"region":{"top_left_x":457,"top_left_y":1894,"width":1230,"height":47},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bb39d5d1ac144968d6fc6a085a60594","type":"text","conversion_output":true,"text":"Placebo tablets should be stored in the same manner as aspirin tablets: \\(25^{\\circ} C\\) with","text_display":"\n\nPlacebo tablets should be stored in the same manner as aspirin tablets: \\(25^{\\circ} C\\) with","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[455,1938],[1096,1938],[1096,1987],[455,1987]],"region":{"top_left_x":455,"top_left_y":1937,"width":641,"height":51},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"154a594da7404b518abee8696f3f5240","type":"text","conversion_output":true,"text":"excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","text_display":" excursions permitted between \\(15^{\\circ} C -30^{\\circ} C\\).","confidence":1,"confidence_rate":1},{"cnt":[[451,2011],[1401,2011],[1401,2073],[451,2073]],"region":{"top_left_x":451,"top_left_y":2010,"width":950,"height":64},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b6d321e4a254f19af5cb22fc302e727","type":"section_header","conversion_output":false,"children_ids":["56712a417a514e4e86d98a04198a71a7"],"text":"","text_display":""},{"cnt":[[455,2017],[1394,2017],[1394,2065],[455,2065]],"region":{"top_left_x":455,"top_left_y":2017,"width":940,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56712a417a514e4e86d98a04198a71a7","type":"text","conversion_output":true,"parent_id":"1b6d321e4a254f19af5cb22fc302e727","text":"4.3.2 Dosage, Administration, and Compliance","text_display":"\n\n\\subsection*{4.3.2 Dosage, Administration, and Compliance}","confidence":0.99951171875,"confidence_rate":0.9999900326925697},{"cnt":[[451,2062],[849,2062],[849,2118],[451,2118]],"region":{"top_left_x":451,"top_left_y":2062,"width":398,"height":57},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"882b956c54fc4b9aaa1ab5d0037319ad","type":"section_header","conversion_output":false,"children_ids":["4c90f72498724a30b6464438a84bca5d"],"text":"","text_display":""},{"cnt":[[455,2067],[844,2067],[844,2116],[455,2116]],"region":{"top_left_x":455,"top_left_y":2066,"width":390,"height":51},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c90f72498724a30b6464438a84bca5d","type":"text","conversion_output":true,"parent_id":"882b956c54fc4b9aaa1ab5d0037319ad","text":"4.3.2.1 Alteplase","text_display":"\n\n\\subsection*{4.3.2.1 Alteplase}","confidence":0.9990234375,"confidence_rate":0.9999555900930661},{"cnt":[[458,2118],[1738,2118],[1738,2161],[458,2161]],"region":{"top_left_x":457,"top_left_y":2118,"width":1282,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"436d3df5631c40bc8fa94b7ef205d8c9","type":"text","conversion_output":true,"text":"For AIS, the recommended dose is \\(0.9 mg / kg\\) infused over 60 minutes with \\(10 \\%\\) of the","text_display":"\n\nFor AIS, the recommended dose is \\(0.9 mg / kg\\) infused over 60 minutes with \\(10 \\%\\) of the","confidence":0.9970715045928955,"confidence_rate":0.9999709628786162},{"cnt":[[455,2161],[1738,2161],[1738,2206],[455,2206]],"region":{"top_left_x":455,"top_left_y":2161,"width":1284,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20f4677032c041bb9bb98b16dfcc7e52","type":"text","conversion_output":true,"text":"total dose administered as an initial IV bolus over 1 minute. The total dose should not","text_display":" total dose administered as an initial IV bolus over 1 minute. The total dose should not","confidence":1,"confidence_rate":1},{"cnt":[[458,2209],[685,2209],[685,2254],[458,2254]],"region":{"top_left_x":457,"top_left_y":2208,"width":229,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a333c3d5727749a4816046ea62d94409","type":"text","conversion_output":true,"text":"exceed 90 mg .","text_display":" exceed 90 mg .","confidence":1,"confidence_rate":1},{"cnt":[[451,2368],[909,2368],[909,2456],[451,2456]],"region":{"top_left_x":451,"top_left_y":2367,"width":458,"height":89},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf7aec01061d44faac5a177818cd29e1","type":"footnote","conversion_output":false,"children_ids":["dbf79113406c4d4794c7c7b8b5926639","42659c3535804b628c08d6d5efa0ae4a"],"text":"","text_display":""},{"cnt":[[458,2374],[857,2374],[857,2417],[458,2417]],"region":{"top_left_x":457,"top_left_y":2374,"width":401,"height":43},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbf79113406c4d4794c7c7b8b5926639","type":"text","conversion_output":true,"parent_id":"bf7aec01061d44faac5a177818cd29e1","text":"Alteplase-Genentech, Inc.","text_display":"\n\n\\footnotetext{\nAlteplase-Genentech, Inc.","confidence":0.9960982785560191,"confidence_rate":0.9998696967229959},{"cnt":[[458,2411],[900,2411],[900,2451],[458,2451]],"region":{"top_left_x":457,"top_left_y":2410,"width":444,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42659c3535804b628c08d6d5efa0ae4a","type":"text","conversion_output":true,"parent_id":"bf7aec01061d44faac5a177818cd29e1","text":"36/Protocol ML29093, Version 3","text_display":"\n36/Protocol ML29093, Version 3\n}","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8a196b134cf47dba39e3fd6ce84d402","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9912309467396757,"confidence_rate":0.9998645056776341},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3af2d9be5b284cb4b7e1e735c951f314","type":"page_info","conversion_output":false,"text":"581/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-246","page":246,"lines":[{"cnt":[[460,391],[1745,391],[1745,432],[460,432]],"region":{"top_left_x":459,"top_left_y":391,"width":1286,"height":41},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e9433cb4df04bd0ab3d12e56b727c96","type":"text","conversion_output":true,"text":"Because alteplase and alteplase placebo contain no antibacterial preservatives, \\(50- mg\\)","text_display":"\n\nBecause alteplase and alteplase placebo contain no antibacterial preservatives, \\(50- mg\\)","confidence":0.9990236759185791,"confidence_rate":0.9999893826542317},{"cnt":[[460,434],[1760,434],[1760,475],[460,475]],"region":{"top_left_x":459,"top_left_y":433,"width":1301,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84fe6f7658e94d7da5ae8299c5b09dd3","type":"text","conversion_output":true,"text":"vials should be reconstituted immediately before use by adding 50 mL of SWFI, USP, to","text_display":" vials should be reconstituted immediately before use by adding 50 mL of SWFI, USP, to","confidence":0.9990234375,"confidence_rate":0.9999897154250147},{"cnt":[[460,481],[1755,481],[1755,522],[460,522]],"region":{"top_left_x":459,"top_left_y":481,"width":1297,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"991ef4fb70dc4fd283d59468ac41583f","type":"text","conversion_output":true,"text":"the vial; this yields a concentration of \\(1 mg / mL\\). Using aseptic technique, direct the flow","text_display":" the vial; this yields a concentration of \\(1 mg / mL\\). Using aseptic technique, direct the flow","confidence":1,"confidence_rate":1},{"cnt":[[460,526],[1678,526],[1678,569],[460,569]],"region":{"top_left_x":459,"top_left_y":526,"width":1219,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99c01d9490e048fbbff8f534f22a39d2","type":"text","conversion_output":true,"text":"of SWFI directly into the lyophilized cake of study drug. It is recommended that an","text_display":" of SWFI directly into the lyophilized cake of study drug. It is recommended that an","confidence":1,"confidence_rate":1},{"cnt":[[460,571],[1725,571],[1725,612],[460,612]],"region":{"top_left_x":459,"top_left_y":571,"width":1267,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9677a98fe114e3299b5881bcfdb8f7b","type":"text","conversion_output":true,"text":"\\(18-\\) gauge needle be used for the reconstitution of the \\(50- mg\\) vial. Once reconstituted,","text_display":" \\(18-\\) gauge needle be used for the reconstitution of the \\(50- mg\\) vial. Once reconstituted,","confidence":0.5806913764681667,"confidence_rate":0.9943541661198486},{"cnt":[[460,614],[1738,614],[1738,660],[460,660]],"region":{"top_left_x":459,"top_left_y":614,"width":1280,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df936cbe9dc44039a08031f2d5b8e7c1","type":"text","conversion_output":true,"text":"gently swirl the vial. Do not shake. Slight foaming upon reconstitution is not unusual;","text_display":" gently swirl the vial. Do not shake. Slight foaming upon reconstitution is not unusual;","confidence":1,"confidence_rate":1},{"cnt":[[458,662],[1714,662],[1714,707],[458,707]],"region":{"top_left_x":457,"top_left_y":661,"width":1258,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a128a5ebe02f4a5b8479291e98012025","type":"text","conversion_output":true,"text":"allowing the vial to stand undisturbed for several minutes is usually sufficient to allow","text_display":" allowing the vial to stand undisturbed for several minutes is usually sufficient to allow","confidence":1,"confidence_rate":1},{"cnt":[[460,709],[1721,709],[1721,750],[460,750]],"region":{"top_left_x":459,"top_left_y":708,"width":1262,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21b228ec7040416bb9fb7973ea5e5719","type":"text","conversion_output":true,"text":"dissipation of any large bubbles. Before further dilution or administration, the product","text_display":" dissipation of any large bubbles. Before further dilution or administration, the product","confidence":1,"confidence_rate":1},{"cnt":[[458,752],[1725,752],[1725,797],[458,797]],"region":{"top_left_x":457,"top_left_y":751,"width":1269,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ac2d0f4ba8042f08c7edd2f87ad6823","type":"text","conversion_output":true,"text":"should be visually inspected for particulate matter and discoloration. If a precipitate is","text_display":" should be visually inspected for particulate matter and discoloration. If a precipitate is","confidence":1,"confidence_rate":1},{"cnt":[[460,799],[1021,799],[1021,840],[460,840]],"region":{"top_left_x":459,"top_left_y":799,"width":562,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d15d4ef7451043cb9c092535a5980e17","type":"text","conversion_output":true,"text":"seen, the product should not be used.","text_display":" seen, the product should not be used.","confidence":1,"confidence_rate":1},{"cnt":[[455,881],[1766,881],[1766,924],[455,924]],"region":{"top_left_x":455,"top_left_y":880,"width":1312,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7bdff277b8834c199b3a7e4a105ebc9c","type":"text","conversion_output":true,"text":"After reconstitution, alteplase should be administered at \\(1 mg / mL\\). As an alternative, the","text_display":"\n\nAfter reconstitution, alteplase should be administered at \\(1 mg / mL\\). As an alternative, the","confidence":1,"confidence_rate":1},{"cnt":[[460,928],[1704,928],[1704,971],[460,971]],"region":{"top_left_x":459,"top_left_y":928,"width":1245,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"575da9d9a4b045e4bfa6625f2e4e4087","type":"text","conversion_output":true,"text":"reconstituted solution may be diluted further immediately before administration in an","text_display":" reconstituted solution may be diluted further immediately before administration in an","confidence":1,"confidence_rate":1},{"cnt":[[460,971],[1755,971],[1755,1016],[460,1016]],"region":{"top_left_x":459,"top_left_y":971,"width":1297,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf8c3b1010ee4298a6eb03cfe2bc5074","type":"text","conversion_output":true,"text":"equal volume of \\(0.9 \\%\\) sodium chloride injection, USP, or \\(5 \\%\\) dextrose injection, USP, to","text_display":" equal volume of \\(0.9 \\%\\) sodium chloride injection, USP, or \\(5 \\%\\) dextrose injection, USP, to","confidence":0.9990234375,"confidence_rate":0.9999899274770393},{"cnt":[[458,1018],[1691,1018],[1691,1061],[458,1061]],"region":{"top_left_x":457,"top_left_y":1018,"width":1234,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"beee9cd63984454eab96bf922c47de4c","type":"text","conversion_output":true,"text":"yield a concentration of \\(0.5 mg / mL\\). The osmolality of this solution is approximately","text_display":" yield a concentration of \\(0.5 mg / mL\\). The osmolality of this solution is approximately","confidence":1,"confidence_rate":1},{"cnt":[[458,1061],[1699,1061],[1699,1106],[458,1106]],"region":{"top_left_x":457,"top_left_y":1061,"width":1243,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6ca8c22ea184098a2392ed3c2b78007","type":"text","conversion_output":true,"text":"\\(215 mOsm / kg\\). Polyvinyl chloride bags, glass bottles, or polypropylene syringes are","text_display":" \\(215 mOsm / kg\\). Polyvinyl chloride bags, glass bottles, or polypropylene syringes are","confidence":1,"confidence_rate":1},{"cnt":[[458,1109],[1772,1109],[1772,1154],[458,1154]],"region":{"top_left_x":457,"top_left_y":1108,"width":1316,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60021622763248d08c40b0bdc02bb45a","type":"text","conversion_output":true,"text":"acceptable. Do not use filter needles for infusion. Alteplase is stable for up to 8 hours in","text_display":" acceptable. Do not use filter needles for infusion. Alteplase is stable for up to 8 hours in","confidence":1,"confidence_rate":1},{"cnt":[[458,1154],[1738,1154],[1738,1197],[458,1197]],"region":{"top_left_x":457,"top_left_y":1153,"width":1282,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23bb21c8bfbb4298b978ded4ec198ca3","type":"text","conversion_output":true,"text":"these solutions at room temperature. Exposure to light has no effect on the stability of","text_display":" these solutions at room temperature. Exposure to light has no effect on the stability of","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[458,1199],[1768,1199],[1768,1244],[458,1244]],"region":{"top_left_x":457,"top_left_y":1198,"width":1312,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c79c45442232462ebf88ed8572acfa92","type":"text","conversion_output":true,"text":"these solutions. Excessive agitation during dilution should be avoided; mixing should be","text_display":" these solutions. 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If an MRI is used in","text_display":"\n\nNeuroimaging may consist of a non-contrast CT or MRI of the brain. If an MRI is used in","confidence":1,"confidence_rate":1},{"cnt":[[455,1740],[1646,1740],[1646,1785],[455,1785]],"region":{"top_left_x":455,"top_left_y":1740,"width":1191,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b70f870ee1de44e889597a1a592fc654","type":"text","conversion_output":true,"text":"the acute setting (to determine study eligibility), it must include the following at a","text_display":" the acute setting (to determine study eligibility), it must include the following at a","confidence":1,"confidence_rate":1},{"cnt":[[458,1788],[1764,1788],[1764,1833],[458,1833]],"region":{"top_left_x":457,"top_left_y":1787,"width":1307,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"954e78add5bc455195617eee09b72381","type":"text","conversion_output":true,"text":"minimum: (1) DW MRI, (2) either susceptibility-weighted (SW) imaging or gradient echo","text_display":" minimum: (1) DW MRI, (2) either susceptibility-weighted (SW) imaging or gradient echo","confidence":1,"confidence_rate":1},{"cnt":[[460,1833],[1139,1833],[1139,1876],[460,1876]],"region":{"top_left_x":459,"top_left_y":1832,"width":680,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82b243fe20bc41718ef3bf48f9a5d7c5","type":"text","conversion_output":true,"text":"(GRE) sequences, and (3) FLAIR sequences.","text_display":" (GRE) sequences, and (3) FLAIR sequences.","confidence":0.99951171875,"confidence_rate":0.9999893826542317},{"cnt":[[458,1916],[1772,1916],[1772,1962],[458,1962]],"region":{"top_left_x":457,"top_left_y":1916,"width":1316,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"301d6615557141e1bd41b7a4bb23f4ce","type":"text","conversion_output":true,"text":"Non-contrast CT or MRI will be performed at baseline to ensure that the patient does not","text_display":"\n\nNon-contrast CT or MRI will be performed at baseline to ensure that the patient does not","confidence":1,"confidence_rate":1},{"cnt":[[458,1962],[1381,1962],[1381,2004],[458,2004]],"region":{"top_left_x":457,"top_left_y":1961,"width":925,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1919c7d166544249aad9a68074de25b2","type":"text","conversion_output":true,"text":"have evidence of acute ICH prior to study drug administration.","text_display":" have evidence of acute ICH prior to study drug administration.","confidence":1,"confidence_rate":1},{"cnt":[[455,2045],[1671,2045],[1671,2088],[455,2088]],"region":{"top_left_x":455,"top_left_y":2045,"width":1217,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6714dd72cc8440ad8c43b089c5d780c7","type":"text","conversion_output":true,"text":"An additional non-contrast CT or MRI will be performed at 22 to 36 hours from the","text_display":"\n\nAn additional non-contrast CT or MRI will be performed at 22 to 36 hours from the","confidence":1,"confidence_rate":1},{"cnt":[[455,2088],[1751,2088],[1751,2133],[455,2133]],"region":{"top_left_x":455,"top_left_y":2088,"width":1296,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a131843c294457992a95197330b5b49","type":"text","conversion_output":true,"text":"initiation (bolus) of study drug infusion. 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The","text_display":" more fully characterize the clinical profile of alteplase in this patient population. The","confidence":1,"confidence_rate":1},{"cnt":[[460,1061],[1721,1061],[1721,1104],[460,1104]],"region":{"top_left_x":459,"top_left_y":1061,"width":1262,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d342e330b9ef4eeca3bbfc0d98164527","type":"text","conversion_output":true,"text":"PRO questionnaires will be distributed by the investigator staff and completed in their","text_display":" PRO questionnaires will be distributed by the investigator staff and completed in their","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[460,1109],[1055,1109],[1055,1149],[460,1149]],"region":{"top_left_x":459,"top_left_y":1108,"width":596,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"127b588522c54680a8aab77dca5edb09","type":"text","conversion_output":true,"text":"entirety by the patient or their surrogate.","text_display":" entirety by the patient or their surrogate.","confidence":1,"confidence_rate":1},{"cnt":[[460,1190],[1742,1190],[1742,1231],[460,1231]],"region":{"top_left_x":459,"top_left_y":1190,"width":1284,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"839271fe6fee4099b56b54a7b99b9aed","type":"text","conversion_output":true,"text":"This study will assess the impact of alteplase treatment on health-related quality of life,","text_display":"\n\nThis study will assess the impact of alteplase treatment on health-related quality of life,","confidence":1,"confidence_rate":1},{"cnt":[[460,1238],[1422,1238],[1422,1278],[460,1278]],"region":{"top_left_x":459,"top_left_y":1237,"width":964,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e869d6ee21f746f6942b9ab437a3a6a1","type":"text","conversion_output":true,"text":"physical function, daily functioning, and symptoms of depression.","text_display":" physical function, daily functioning, and symptoms of depression.","confidence":1,"confidence_rate":1},{"cnt":[[460,1319],[1772,1319],[1772,1362],[460,1362]],"region":{"top_left_x":459,"top_left_y":1319,"width":1314,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b08200e10f44730af33410fcb9e968c","type":"text","conversion_output":true,"text":"Health-related quality of life will be assessed using the EQ-5D (Appendix 4). 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Bleeding may result in","confidence":1,"confidence_rate":1},{"cnt":[[460,578],[1300,578],[1300,621],[460,621]],"region":{"top_left_x":459,"top_left_y":577,"width":841,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dd5da1e97404db389c835694c86c691","type":"text","conversion_output":true,"text":"life-threatening situations, permanent disability, or death.","text_display":" life-threatening situations, permanent disability, or death.","confidence":1,"confidence_rate":1},{"cnt":[[460,636],[1742,636],[1742,677],[460,677]],"region":{"top_left_x":459,"top_left_y":635,"width":1284,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca34f7cd03934ce7b41dbaf280bae719","type":"text","conversion_output":true,"text":"- The incidence of ICH, especially symptomatic ICH, in patients with AIS is higher in","text_display":"\n- The incidence of ICH, especially symptomatic ICH, in patients with AIS is higher in","confidence":1,"confidence_rate":1},{"cnt":[[524,679],[1710,679],[1710,720],[524,720]],"region":{"top_left_x":524,"top_left_y":678,"width":1187,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39bb480dbefb4d05aa22aeee11c0d220","type":"text","conversion_output":true,"text":"alteplase-treated patients than placebo-treated patients in published studies (for","text_display":" alteplase-treated patients than placebo-treated patients in published studies (for","confidence":1,"confidence_rate":1},{"cnt":[[524,718],[1199,718],[1199,763],[524,763]],"region":{"top_left_x":524,"top_left_y":717,"width":675,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"350ef5ca43a4489da569da25f0607376","type":"text","conversion_output":true,"text":"detailed information, see the alteplase USPI).","text_display":" detailed information, see the alteplase USPI).","confidence":1,"confidence_rate":1},{"cnt":[[455,786],[900,786],[900,838],[455,838]],"region":{"top_left_x":455,"top_left_y":786,"width":446,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2aec323e65604af7bd9146669cc87012","type":"section_header","conversion_output":false,"children_ids":["d43ca48ccae54df5949d571df7103339"],"text":"","text_display":""},{"cnt":[[460,791],[896,791],[896,836],[460,836]],"region":{"top_left_x":459,"top_left_y":790,"width":437,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d43ca48ccae54df5949d571df7103339","type":"text","conversion_output":true,"parent_id":"2aec323e65604af7bd9146669cc87012","text":"Management of Bleeding","text_display":"\n\n\\section*{Management of Bleeding}","confidence":1,"confidence_rate":1},{"cnt":[[460,842],[1678,842],[1678,883],[460,883]],"region":{"top_left_x":459,"top_left_y":842,"width":1219,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b852d3032eae4f01837dd0c8b961a192","type":"text","conversion_output":true,"text":"Patients will be excluded for the presence of conditions related to risks of bleeding","text_display":"\n\nPatients will be excluded for the presence of conditions related to risks of bleeding","confidence":1,"confidence_rate":1},{"cnt":[[460,885],[1682,885],[1682,930],[460,930]],"region":{"top_left_x":459,"top_left_y":885,"width":1224,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c0ad52dca1c44068cfb13963435effb","type":"text","conversion_output":true,"text":"(as outlined in Section 4.1.2, Exclusion Criteria). A non-contrast cranial CT or MRI","text_display":" (as outlined in Section 4.1.2, Exclusion Criteria). A non-contrast cranial CT or MRI","confidence":1,"confidence_rate":1},{"cnt":[[460,932],[1734,932],[1734,973],[460,973]],"region":{"top_left_x":459,"top_left_y":932,"width":1275,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2539ce1e121c45e889e7084d9659885c","type":"text","conversion_output":true,"text":"(including either SW or GRE to detect ICH) should be performed at baseline to ensure","text_display":" (including either SW or GRE to detect ICH) should be performed at baseline to ensure","confidence":1,"confidence_rate":1},{"cnt":[[458,975],[1654,975],[1654,1021],[458,1021]],"region":{"top_left_x":457,"top_left_y":975,"width":1198,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15365333e89b46a7a90767b712365a53","type":"text","conversion_output":true,"text":"that the patient does not have evidence of ICH prior to study drug administration.","text_display":" that the patient does not have evidence of ICH prior to study drug administration.","confidence":1,"confidence_rate":1},{"cnt":[[460,1061],[1691,1061],[1691,1102],[460,1102]],"region":{"top_left_x":459,"top_left_y":1061,"width":1232,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7072da03606a41c8aee9c8fb7bfb7d67","type":"text","conversion_output":true,"text":"Fibrin, which is part of the hemostatic plug formed at needle puncture sites, may be","text_display":"\n\nFibrin, which is part of the hemostatic plug formed at needle puncture sites, may be","confidence":1,"confidence_rate":1},{"cnt":[[460,1106],[1766,1106],[1766,1149],[460,1149]],"region":{"top_left_x":459,"top_left_y":1106,"width":1308,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78ce61900a6a4abba1c7febf40cdfac0","type":"text","conversion_output":true,"text":"lysed during alteplase therapy. Therefore, alteplase therapy requires careful attention to","text_display":" lysed during alteplase therapy. Therefore, alteplase therapy requires careful attention to","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[460,1152],[1762,1152],[1762,1195],[460,1195]],"region":{"top_left_x":459,"top_left_y":1151,"width":1303,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"142ce085fd08411baa5a04a3b3261b5f","type":"text","conversion_output":true,"text":"potential bleeding sites, e.g., catheter-insertion sites and arterial-puncture sites. Arterial","text_display":" potential bleeding sites, e.g., catheter-insertion sites and arterial-puncture sites. Arterial","confidence":1,"confidence_rate":1},{"cnt":[[460,1199],[1680,1199],[1680,1240],[460,1240]],"region":{"top_left_x":459,"top_left_y":1198,"width":1222,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6f041d01bf2436581f0b7d33b21922c","type":"text","conversion_output":true,"text":"and venous punctures should be minimized. Non-compressible arterial, as well as","text_display":" and venous punctures should be minimized. Non-compressible arterial, as well as","confidence":1,"confidence_rate":1},{"cnt":[[460,1242],[1656,1242],[1656,1285],[460,1285]],"region":{"top_left_x":459,"top_left_y":1241,"width":1198,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b612db855f744549e4e3cb4cec06b51","type":"text","conversion_output":true,"text":"internal jugular and subclavian venous punctures, should be avoided to minimize","text_display":" internal jugular and subclavian venous punctures, should be avoided to minimize","confidence":1,"confidence_rate":1},{"cnt":[[460,1289],[1755,1289],[1755,1330],[460,1330]],"region":{"top_left_x":459,"top_left_y":1289,"width":1297,"height":41},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d46ed21630564be89ef193f715db8da1","type":"text","conversion_output":true,"text":"bleeding from non-compressible sites. In the event of serious bleeding (not controllable","text_display":" bleeding from non-compressible sites. In the event of serious bleeding (not controllable","confidence":1,"confidence_rate":1},{"cnt":[[460,1332],[1639,1332],[1639,1377],[460,1377]],"region":{"top_left_x":459,"top_left_y":1332,"width":1181,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f50531103a8241419a73ef2f81dc869f","type":"text","conversion_output":true,"text":"by local pressure) or occurring in a critical location (intracranial, gastrointestinal,","text_display":" by local pressure) or occurring in a critical location (intracranial, gastrointestinal,","confidence":1,"confidence_rate":1},{"cnt":[[460,1379],[1622,1379],[1622,1420],[460,1420]],"region":{"top_left_x":459,"top_left_y":1379,"width":1164,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"218c591144d14a0c8a8b9c889845fb1c","type":"text","conversion_output":true,"text":"retroperitoneal, or pericardial), study drug should be discontinued immediately.","text_display":" retroperitoneal, or pericardial), study drug should be discontinued immediately.","confidence":1,"confidence_rate":1},{"cnt":[[460,1422],[1783,1422],[1783,1467],[460,1467]],"region":{"top_left_x":459,"top_left_y":1422,"width":1325,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0275f7cba2a846a3b0dc52eb1ffa810e","type":"text","conversion_output":true,"text":"Supportive care and medical management of AEs are at the discretion of the investigator.","text_display":" Supportive care and medical management of AEs are at the discretion of the investigator.","confidence":1,"confidence_rate":1},{"cnt":[[455,1497],[1132,1497],[1132,1549],[455,1549]],"region":{"top_left_x":455,"top_left_y":1497,"width":678,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11fc5c5694514fdfa2712f30aac08a18","type":"section_header","conversion_output":false,"children_ids":["fc06f1087294440a84fbe78bd413f174"],"text":"","text_display":""},{"cnt":[[460,1504],[1128,1504],[1128,1545],[460,1545]],"region":{"top_left_x":459,"top_left_y":1503,"width":669,"height":42},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc06f1087294440a84fbe78bd413f174","type":"text","conversion_output":true,"parent_id":"11fc5c5694514fdfa2712f30aac08a18","text":"5.1.2 Risk of Allergic Reactions","text_display":"\n\n\\subsection*{5.1.2 Risk of Allergic Reactions}","confidence":1,"confidence_rate":1},{"cnt":[[455,1560],[1648,1560],[1648,1601],[455,1601]],"region":{"top_left_x":455,"top_left_y":1559,"width":1193,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4353f1d745e046cca93ac5804b9ec89e","type":"text","conversion_output":true,"text":"Allergic-type reactions, e.g., anaphylactoid reaction, laryngeal edema, orolingual","text_display":"\n\nAllergic-type reactions, e.g., anaphylactoid reaction, laryngeal edema, orolingual","confidence":1,"confidence_rate":1},{"cnt":[[458,1605],[1755,1605],[1755,1648],[458,1648]],"region":{"top_left_x":457,"top_left_y":1604,"width":1299,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd7beca1a7254280b32abdf4de75543b","type":"text","conversion_output":true,"text":"angioedema, rash, and urticaria, have been reported. When such reactions occur, they","text_display":" angioedema, rash, and urticaria, have been reported. When such reactions occur, they","confidence":1,"confidence_rate":1},{"cnt":[[460,1650],[1061,1650],[1061,1695],[460,1695]],"region":{"top_left_x":459,"top_left_y":1650,"width":603,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"336aaebe7ffa4c39bb22a5f32bcd7ce0","type":"text","conversion_output":true,"text":"usually respond to conventional therapy.","text_display":" usually respond to conventional therapy.","confidence":1,"confidence_rate":1},{"cnt":[[460,1732],[1725,1732],[1725,1777],[460,1777]],"region":{"top_left_x":459,"top_left_y":1731,"width":1267,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06d68350fc4145bfbca09fd071c013e8","type":"text","conversion_output":true,"text":"There have been postmarketing reports of orolingual angioedema associated with the","text_display":"\n\nThere have been postmarketing reports of orolingual angioedema associated with the","confidence":1,"confidence_rate":1},{"cnt":[[460,1779],[1729,1779],[1729,1824],[460,1824]],"region":{"top_left_x":459,"top_left_y":1778,"width":1271,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c0aadc8426d4c108431765e5959a6d3","type":"text","conversion_output":true,"text":"use of alteplase. Most were patients treated for AIS. Many of these patients received","text_display":" use of alteplase. Most were patients treated for AIS. Many of these patients received","confidence":1,"confidence_rate":1},{"cnt":[[460,1826],[1714,1826],[1714,1867],[460,1867]],"region":{"top_left_x":459,"top_left_y":1826,"width":1256,"height":41},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e743862aa2634aec9931e1c633701329","type":"text","conversion_output":true,"text":"concomitant angiotensin-converting enzyme inhibitors, and most cases resolved with","text_display":" concomitant angiotensin-converting enzyme inhibitors, and most cases resolved with","confidence":1,"confidence_rate":1},{"cnt":[[460,1869],[728,1869],[728,1912],[460,1912]],"region":{"top_left_x":459,"top_left_y":1869,"width":270,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60fc3d46bde9427e9438a0026ed9a40a","type":"text","conversion_output":true,"text":"prompt treatment.","text_display":" prompt 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instituted.","confidence":1,"confidence_rate":1},{"cnt":[[455,2114],[1420,2114],[1420,2159],[455,2159]],"region":{"top_left_x":455,"top_left_y":2114,"width":966,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7766fdd4dacb4563b8d169b201e47d99","type":"section_header","conversion_output":false,"children_ids":["5b8ff4482e454416a8d7d0604519409a"],"text":"","text_display":""},{"cnt":[[460,2118],[1416,2118],[1416,2155],[460,2155]],"region":{"top_left_x":459,"top_left_y":2118,"width":957,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b8ff4482e454416a8d7d0604519409a","type":"text","conversion_output":true,"parent_id":"7766fdd4dacb4563b8d169b201e47d99","text":"5.2 SAFETY PARAMETERS AND DEFINITIONS","text_display":"\n\n\\subsection*{5.2 SAFETY PARAMETERS AND 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However, if a constellation of signs","text_display":" jaundice, asterixis, and elevated transaminases). 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A laboratory test result must be","text_display":"\n\nNot every laboratory abnormality qualifies as an AE. A laboratory test result must be","confidence":1,"confidence_rate":1},{"cnt":[[460,2118],[1300,2118],[1300,2159],[460,2159]],"region":{"top_left_x":459,"top_left_y":2118,"width":841,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9278e43f7b44a63bcb213c4c4a97d6c","type":"text","conversion_output":true,"text":"reported as an AE if it meets any of the following criteria:","text_display":" reported as an AE if it meets any of the following criteria:","confidence":0.896571159362793,"confidence_rate":0.9984634687951148},{"cnt":[[460,2179],[1079,2179],[1079,2219],[460,2219]],"region":{"top_left_x":459,"top_left_y":2178,"width":620,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaa32ea249df43edade4c61600c6fc74","type":"text","conversion_output":true,"text":"- Is accompanied by clinical symptoms","text_display":"\n- Is accompanied by clinical 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medical intervention (e.g., potassium supplementation for hypokalemia)","confidence":1,"confidence_rate":1},{"cnt":[[524,430],[1055,430],[1055,471],[524,471]],"region":{"top_left_x":524,"top_left_y":429,"width":531,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa6354ab97e841d0b6a1f72996ef3fb8","type":"text","conversion_output":true,"text":"or a change in concomitant therapy","text_display":" or a change in concomitant therapy","confidence":1,"confidence_rate":1},{"cnt":[[460,486],[1291,486],[1291,529],[460,529]],"region":{"top_left_x":459,"top_left_y":485,"width":833,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fcfbfb3378645d3a9d3ab2ead8cc96c","type":"text","conversion_output":true,"text":"- Is clinically significant in the investigator's judgment","text_display":"\n- Is clinically significant in the investigator's 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If the laboratory abnormality can be","text_display":" potassium\" as opposed to \"abnormal potassium\"). If the laboratory abnormality can be","confidence":1,"confidence_rate":1},{"cnt":[[460,1139],[1755,1139],[1755,1184],[460,1184]],"region":{"top_left_x":459,"top_left_y":1138,"width":1297,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10f0f30773e0477a9b39e0d83c9f972e","type":"text","conversion_output":true,"text":"characterized by a precise clinical term per standard definitions, the clinical term should","text_display":" characterized by a precise clinical term per standard definitions, the clinical term should","confidence":1,"confidence_rate":1},{"cnt":[[460,1186],[1712,1186],[1712,1231],[460,1231]],"region":{"top_left_x":459,"top_left_y":1185,"width":1254,"height":47},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d826f2e0c824ce4af05a46bc4082a7c","type":"text","conversion_output":true,"text":"be recorded as the AE. 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Medical and scientific","text_display":"\n\nIt is the investigator's responsibility to review all vital sign findings. Medical and scientific","confidence":1,"confidence_rate":1},{"cnt":[[455,1972],[1697,1972],[1697,2017],[455,2017]],"region":{"top_left_x":455,"top_left_y":1972,"width":1243,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"039adf5d83344edc9123dc225984e170","type":"text","conversion_output":true,"text":"judgment should be exercised in deciding whether an isolated vital sign abnormality","text_display":" judgment should be exercised in deciding whether an isolated vital sign abnormality","confidence":1,"confidence_rate":1},{"cnt":[[458,2020],[909,2020],[909,2060],[458,2060]],"region":{"top_left_x":457,"top_left_y":2019,"width":452,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7cdab0d67034c32bb3ced662fdb47f0","type":"text","conversion_output":true,"text":"should be classified as an AE.","text_display":" should be classified as an 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visit","text_display":"\n\nObservations of the same clinically significant vital sign abnormality from visit to visit","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[460,434],[1676,434],[1676,477],[460,477]],"region":{"top_left_x":459,"top_left_y":433,"width":1217,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c45ebcff256944f7bd43fbe6b931fed5","type":"text","conversion_output":true,"text":"should only be recorded once on the Adverse Event eCRF (see Section 5.3.3.3 for","text_display":" should only be recorded once on the Adverse Event eCRF (see Section 5.3.3.3 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recorded on the Adverse Event eCRF","confidence":1,"confidence_rate":1},{"cnt":[[458,696],[1674,696],[1674,741],[458,741]],"region":{"top_left_x":457,"top_left_y":696,"width":1217,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78734d4301ef4b908e4e62c073d7d678","type":"text","conversion_output":true,"text":"and immediately reported to the Sponsor (see Section 5.2.2). 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Every effort should be made to follow all SAEs considered to","text_display":" patient withdraws consent. 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non-adherence rate (due to lost to follow-up, consent withdrawal, treatment crossovers,","confidence":1,"confidence_rate":1},{"cnt":[[460,1222],[1751,1222],[1751,1268],[460,1268]],"region":{"top_left_x":459,"top_left_y":1222,"width":1292,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1829ffc69ae8452f992f7cea5d2a1cc3","type":"text","conversion_output":true,"text":"and stroke mimics), the above sample size needs to be inflated by a factor of \\(1 / 0.95^{2}\\) or","text_display":" and stroke mimics), the above sample size needs to be inflated by a factor of \\(1 / 0.95^{2}\\) or","confidence":0.9980478286743164,"confidence_rate":0.9999810285363133},{"cnt":[[460,1272],[1729,1272],[1729,1313],[460,1313]],"region":{"top_left_x":459,"top_left_y":1271,"width":1271,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"719541dc372b4d2eb1263e8d712fd119","type":"text","conversion_output":true,"text":"1.108 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Therefore, a total sample size of 948 is required for this","text_display":" 1.108 (Friedman et al. 1998). Therefore, a total sample size of 948 is required for this","confidence":1,"confidence_rate":1},{"cnt":[[460,1319],[552,1319],[552,1360],[460,1360]],"region":{"top_left_x":459,"top_left_y":1319,"width":94,"height":41},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a42231da5eb4cb2bce8ebfef23b85fb","type":"text","conversion_output":true,"text":"study.","text_display":" study.","confidence":1,"confidence_rate":1},{"cnt":[[455,1388],[1042,1388],[1042,1433],[455,1433]],"region":{"top_left_x":455,"top_left_y":1387,"width":587,"height":47},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bd6e3fd968546898b9fba04981acfc6","type":"section_header","conversion_output":false,"children_ids":["67ce38bc4bae47e68e890858dd105133"],"text":"","text_display":""},{"cnt":[[460,1392],[1040,1392],[1040,1429],[460,1429]],"region":{"top_left_x":459,"top_left_y":1392,"width":581,"height":37},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67ce38bc4bae47e68e890858dd105133","type":"text","conversion_output":true,"parent_id":"2bd6e3fd968546898b9fba04981acfc6","text":"6.2 PRIMARY ANALYSIS","text_display":"\n\n\\subsection*{6.2 PRIMARY ANALYSIS}","confidence":0.9990234375,"confidence_rate":0.9999609191777622},{"cnt":[[460,1457],[1659,1457],[1659,1497],[460,1497]],"region":{"top_left_x":459,"top_left_y":1456,"width":1200,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5951cd2b59d49b1bb15f1e1fe9114a7","type":"text","conversion_output":true,"text":"The primary efficacy analysis will test the hypothesis of superiority of IV alteplase","text_display":"\n\nThe primary efficacy analysis will test the hypothesis of superiority of IV alteplase","confidence":1,"confidence_rate":1},{"cnt":[[460,1502],[1669,1502],[1669,1543],[460,1543]],"region":{"top_left_x":459,"top_left_y":1501,"width":1211,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e15c358364f641ab82f30d1773d54d5b","type":"text","conversion_output":true,"text":"therapy over standard medical care in AIS patients with mild deficits. The primary","text_display":" therapy over standard medical care in AIS patients with mild deficits. The primary","confidence":1,"confidence_rate":1},{"cnt":[[460,1547],[1680,1547],[1680,1588],[460,1588]],"region":{"top_left_x":459,"top_left_y":1546,"width":1222,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"356a281894494deab3604822f2ad3e6f","type":"text","conversion_output":true,"text":"efficacy outcome is the proportion of patients with a favorable outcome, defined by","text_display":" efficacy outcome is the proportion of patients with a favorable outcome, defined by","confidence":1,"confidence_rate":1},{"cnt":[[460,1590],[1749,1590],[1749,1631],[460,1631]],"region":{"top_left_x":459,"top_left_y":1589,"width":1290,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80503293f0bd4e4da23aad893ed44682","type":"text","conversion_output":true,"text":"mRS score of 0 or 1 at 90 days post-randomization. The difference in the proportion of","text_display":" mRS score of 0 or 1 at 90 days post-randomization. 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The proportionality assumption will be assessed using the score test as","text_display":" does not hold. The proportionality assumption will be assessed using the score test as","confidence":1,"confidence_rate":1},{"cnt":[[460,2221],[1742,2221],[1742,2262],[460,2262]],"region":{"top_left_x":459,"top_left_y":2221,"width":1284,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b87b557bf084a33abb5b231ec0aeccc","type":"text","conversion_output":true,"text":"well as clinical judgment on the similarities of the different odds ratios. As a secondary","text_display":" well as clinical judgment on the similarities of the different odds ratios. 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The significance of each test is determined at the two-sided alpha level of","text_display":" evidence. The significance of each test is determined at the two-sided alpha level of","confidence":0.97412109375,"confidence_rate":0.9997087129119303},{"cnt":[[458,524],[1738,524],[1738,569],[458,569]],"region":{"top_left_x":457,"top_left_y":524,"width":1282,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a89960956f494b7e92d2a3507f5a379a","type":"text","conversion_output":true,"text":"0.05 . The specific statistical model for analyzing each of these outcome measures will","text_display":" 0.05 . 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The cumulative incidences of each outcome will","text_display":" within 90 days of study drug initiation. The cumulative incidences of each outcome will","confidence":1,"confidence_rate":1},{"cnt":[[458,1018],[1772,1018],[1772,1063],[458,1063]],"region":{"top_left_x":457,"top_left_y":1018,"width":1316,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7487e89b48d42d7a01672d58a35cfeb","type":"text","conversion_output":true,"text":"be compared via Fisher's exact test. Mortality will be analyzed by Log-Rank test and the","text_display":" be compared via Fisher's exact test. Mortality will be analyzed by Log-Rank test and the","confidence":1,"confidence_rate":1},{"cnt":[[458,1066],[1766,1066],[1766,1109],[458,1109]],"region":{"top_left_x":457,"top_left_y":1065,"width":1310,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d33a904d136f40488b1e47318f38654e","type":"text","conversion_output":true,"text":"Kaplan-Meier estimates will be plotted over the observation period of 90 days. No alpha","text_display":" Kaplan-Meier estimates will be plotted over the observation period of 90 days. No alpha","confidence":1,"confidence_rate":1},{"cnt":[[458,1109],[1663,1109],[1663,1154],[458,1154]],"region":{"top_left_x":457,"top_left_y":1108,"width":1206,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e474e115eae64edf86c6342931a0f56e","type":"text","conversion_output":true,"text":"adjustment for multiple testing on the safety endpoints is foreseen because those","text_display":" adjustment for multiple testing on the safety endpoints is foreseen because those","confidence":1,"confidence_rate":1},{"cnt":[[458,1156],[883,1156],[883,1201],[458,1201]],"region":{"top_left_x":457,"top_left_y":1155,"width":427,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a105f7525504f92a45209df524dd4f9","type":"text","conversion_output":true,"text":"analyses will be exploratory.","text_display":" analyses will be exploratory.","confidence":1,"confidence_rate":1},{"cnt":[[451,1222],[1171,1222],[1171,1278],[451,1278]],"region":{"top_left_x":451,"top_left_y":1222,"width":720,"height":57},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da21df4955524df19b27c28a3ab6ddf0","type":"section_header","conversion_output":false,"children_ids":["c655e53f93f14719b4343cb94fffcdd7"],"text":"","text_display":""},{"cnt":[[458,1229],[1164,1229],[1164,1274],[458,1274]],"region":{"top_left_x":457,"top_left_y":1228,"width":708,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c655e53f93f14719b4343cb94fffcdd7","type":"text","conversion_output":true,"parent_id":"da21df4955524df19b27c28a3ab6ddf0","text":"6.4 EXPLORATORY ANALYSES","text_display":"\n\n\\subsection*{6.4 EXPLORATORY ANALYSES}","confidence":0.99951171875,"confidence_rate":0.999983158745329},{"cnt":[[455,1293],[1755,1293],[1755,1336],[455,1336]],"region":{"top_left_x":455,"top_left_y":1293,"width":1301,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"327f5dd2611c46cfa08ef82e79d222f9","type":"text","conversion_output":true,"text":"As exploratory analyses, heterogeneity of treatment effect of alteplase will be evaluated","text_display":"\n\nAs exploratory analyses, heterogeneity of treatment effect of alteplase will be evaluated","confidence":1,"confidence_rate":1},{"cnt":[[458,1336],[1729,1336],[1729,1381],[458,1381]],"region":{"top_left_x":457,"top_left_y":1336,"width":1273,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5d16562734c4ac694214360daa6457f","type":"text","conversion_output":true,"text":"by various pre-specified baseline covariates. The primary pre-specified variables and","text_display":" by various pre-specified baseline covariates. The primary pre-specified variables and","confidence":1,"confidence_rate":1},{"cnt":[[455,1384],[1046,1384],[1046,1429],[455,1429]],"region":{"top_left_x":455,"top_left_y":1383,"width":592,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6330709d6ec34c9baf96705ac3cbbbcd","type":"text","conversion_output":true,"text":"their analytic thresholds are defined by:","text_display":" their analytic thresholds are defined by:","confidence":1,"confidence_rate":1},{"cnt":[[458,1439],[806,1439],[806,1480],[458,1480]],"region":{"top_left_x":457,"top_left_y":1439,"width":349,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c3712547e1a4e8b9ad2099ad2dae7fd","type":"text","conversion_output":true,"text":"- Age (<65 vs. \\(\\geq 65\\) )","text_display":"\n- Age (<65 vs. \\(\\geq 65\\) )","confidence":1,"confidence_rate":1},{"cnt":[[460,1491],[1160,1491],[1160,1534],[460,1534]],"region":{"top_left_x":459,"top_left_y":1491,"width":702,"height":43},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"066766a57d4f495d82bf7b8da1bdb389","type":"text","conversion_output":true,"text":"- Pre-treatment NIHSS score ( \\(0-2\\) vs. 3-5)","text_display":"\n- Pre-treatment NIHSS score ( \\(0-2\\) vs. 3-5)","confidence":0.4962272644042969,"confidence_rate":0.9860833196552973},{"cnt":[[460,1543],[1364,1543],[1364,1583],[460,1583]],"region":{"top_left_x":459,"top_left_y":1542,"width":906,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"182be265ca294edeb9e4b3eebda8c81e","type":"text","conversion_output":true,"text":"- Last known well time to treatment ( \\(0-2\\) vs. \\(>2-3\\) hours)","text_display":"\n- Last known well time to treatment ( \\(0-2\\) vs. \\(>2-3\\) hours)","confidence":0.7661293059413765,"confidence_rate":0.9960899536751268},{"cnt":[[460,1594],[1094,1594],[1094,1635],[460,1635]],"region":{"top_left_x":459,"top_left_y":1594,"width":635,"height":41},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0d36d92b8b7429c86f9d94c74614bec","type":"text","conversion_output":true,"text":"- Stroke subgroup (RISS vs. non-RISS)","text_display":"\n- Stroke subgroup (RISS vs. non-RISS)","confidence":1,"confidence_rate":1},{"cnt":[[455,1669],[1721,1669],[1721,1712],[455,1712]],"region":{"top_left_x":455,"top_left_y":1669,"width":1266,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42c8de642c6e4233a5290bc10d8c3f96","type":"text","conversion_output":true,"text":"Additional heterogeneity analyses will be considered and detailed in the SAP. Forest","text_display":"\n\nAdditional heterogeneity analyses will be considered and detailed in the SAP. Forest","confidence":1,"confidence_rate":1},{"cnt":[[458,1714],[1661,1714],[1661,1760],[458,1760]],"region":{"top_left_x":457,"top_left_y":1714,"width":1204,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b607f14aead04f6e8ea20631ece8130c","type":"text","conversion_output":true,"text":"plots will be constructed to illustrate subgroup analyses. In addition, the two-way","text_display":" plots will be constructed to illustrate subgroup analyses. 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Additional exploratory analyses will be conducted to","text_display":" multivariable logistic regression. 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ASSESSMENTS & Screening and Baseline (Visit 1) & Study Drug Administration & 22-36 Hours from Start of Study Drug Administration (Visit 2) & Day 5 (or Discharge if Sooner) (Visit 3) & 30 Days ( ± 7 Days) Phone Call (Visit 4) & \\(90( \\pm 14)\\) Days/Study Completion (Visit 5) & Early Discontinuation (Phone call, if possible) \\\\\n\\hline Informed consent & X & & & & & & \\\\\n\\hline Review of eligibility & X & & & & & & \\\\\n\\hline Medical history and baseline conditions \\({ }^{\\text {a }}\\) & X & & & & & & \\\\\n\\hline Demographics & X & & & & & & \\\\\n\\hline Neurological examination \\({ }^{\\text {b }}\\) & X & & & & & & \\\\\n\\hline Vital signs \\({ }^{\\text {c }}\\) & X & & & & & & \\\\\n\\hline Complete blood count \\({ }^{\\text {d }}\\) & X & & & & & & \\\\\n\\hline Coagulation status \\({ }^{\\text {e }}\\) & X & & & & & & \\\\\n\\hline Pregnancy test \\({ }^{ f }\\) & X & & & & & & \\\\\n\\hline Serum blood glucose \\({ }^{\\text {g }}\\) & X & & & & & & 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Serum or urine pregnancy test can be collected.","confidence":0.99853515625,"confidence_rate":0.9999891414094549},{"cnt":[[374,1014],[1377,1014],[1377,1055],[374,1055]],"region":{"top_left_x":373,"top_left_y":1014,"width":1005,"height":41},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e437c9bf7884a059f92c0914d089e78","type":"text","conversion_output":true,"text":"\\({ }^{ g }\\) Serum glucose (values of \\(<50 mg / dL\\) are contraindicated for alteplase).","text_display":"\n\\({ }^{ g }\\) Serum glucose (values of \\(<50 mg / dL\\) are contraindicated for alteplase).","confidence":0.99658203125,"confidence_rate":0.9999635770106784},{"cnt":[[374,1053],[1394,1053],[1394,1098],[374,1098]],"region":{"top_left_x":373,"top_left_y":1052,"width":1022,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac23867f1efd44449dc976fe55ec6a96","type":"text","conversion_output":true,"text":"\\({ }^{ h }\\) MRI or CT scan should be performed if any clinical findings suggest ICH.","text_display":"\n\\({ }^{ h }\\) MRI or CT scan should be performed if any clinical findings suggest ICH.","confidence":0.52783203125,"confidence_rate":0.9927651939396394},{"cnt":[[374,1096],[1751,1096],[1751,1141],[374,1141]],"region":{"top_left_x":373,"top_left_y":1095,"width":1378,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ae4aa77cf414e5dab1dfccdef64a8ca","type":"text","conversion_output":true,"text":"\\({ }^{\\text {i }}\\) NIHSS score should be assessed and recorded at the time of any clinical findings that suggest ICH.","text_display":"\n\\({ }^{\\text {i }}\\) NIHSS score should be assessed and recorded at the time of any clinical findings that suggest ICH.","confidence":0.4919471740722656,"confidence_rate":0.9939032820938927},{"cnt":[[374,1139],[1560,1139],[1560,1182],[374,1182]],"region":{"top_left_x":373,"top_left_y":1138,"width":1187,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a3871ac89394a95a5a0bb1b33471151","type":"text","conversion_output":true,"text":"\\({ }^{ j }\\) The mRS may be performed by telephone, if necessary, for visits on Days 30 and 90.","text_display":"\n\\({ }^{ j }\\) The mRS may be performed by telephone, if necessary, for visits on Days 30 and 90.","confidence":0.6990402844854373,"confidence_rate":0.9964259331679598},{"cnt":[[374,1179],[2350,1179],[2350,1225],[374,1225]],"region":{"top_left_x":373,"top_left_y":1179,"width":1978,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ff7cf8dabdc488c9c9e6b1abe304363","type":"text","conversion_output":true,"text":"\\({ }^{ k }\\) The BI, CES-D, EQ-5D, and SIS-16 can be administered by phone interview if an in-person patient visit cannot be scheduled in the allotted time.","text_display":"\n\\({ }^{ k }\\) The BI, CES-D, EQ-5D, and SIS-16 can be administered by phone interview if an in-person patient visit cannot be scheduled in the allotted time.","confidence":0.9912149906158447,"confidence_rate":0.9999445057846589},{"cnt":[[374,1222],[2279,1222],[2279,1265],[374,1265]],"region":{"top_left_x":373,"top_left_y":1222,"width":1907,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f56d62e8c002414485caeb052d37a220","type":"text","conversion_output":true,"text":"\\({ }^{1}\\) Assessments include: Controlled Oral Word Association test; HVLT-R trials 1, 2, and 3; digit symbol coding from the WAIS III; Forward and","text_display":"\n\\({ }^{1}\\) Assessments include: Controlled Oral Word Association test; HVLT-R trials 1, 2, and 3; digit symbol coding from the WAIS III; Forward and","confidence":0.9970724582672119,"confidence_rate":0.9999804546219134},{"cnt":[[408,1263],[2340,1263],[2340,1304],[408,1304]],"region":{"top_left_x":408,"top_left_y":1263,"width":1932,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27adfb6756d84871a874da2b45ccfb78","type":"text","conversion_output":true,"text":"Backward Digit Span test; Benton Judgment of Line Orientation, form V; HVLT-R trial 4 and recognition; semantic fluency (Animal Naming test);","text_display":" Backward Digit Span test; Benton Judgment of Line Orientation, form V; HVLT-R trial 4 and recognition; semantic fluency (Animal Naming test);","confidence":1,"confidence_rate":1},{"cnt":[[408,1302],[821,1302],[821,1343],[408,1343]],"region":{"top_left_x":408,"top_left_y":1301,"width":413,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"367cdcfd9ba4495c9a9753a3d50c31e5","type":"text","conversion_output":true,"text":"and BNT (15-item short form).","text_display":" and BNT (15-item short form).","confidence":0.98974609375,"confidence_rate":0.9996969035986627},{"cnt":[[374,1341],[2346,1341],[2346,1381],[374,1381]],"region":{"top_left_x":373,"top_left_y":1340,"width":1974,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a6cf4cdac884e3cbbb867dfa092db2d","type":"text","conversion_output":true,"text":"\\({ }^{ m }\\) Assessment of walking speed requires an in-person patient visit and is best combined with administration of the BI, CES-D, EQ-5D, and SIS-16.","text_display":"\n\\({ }^{ m }\\) Assessment of walking speed requires an in-person patient visit and is best combined with administration of the BI, CES-D, EQ-5D, and SIS-16.","confidence":0.7432987643405795,"confidence_rate":0.9981122476827983},{"cnt":[[374,1381],[2254,1381],[2254,1424],[374,1424]],"region":{"top_left_x":373,"top_left_y":1381,"width":1881,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5713d69e21c9480b883f7f486aaf3db9","type":"text","conversion_output":true,"text":"\\({ }^{ n }\\) Concomitant medications include any prescription medications or over-the-counter preparations used by the patient within 7 days prior to","text_display":"\n\\({ }^{ n }\\) Concomitant medications include any prescription medications or over-the-counter preparations used by the patient within 7 days prior to","confidence":0.9760856628417969,"confidence_rate":0.9998438513723666},{"cnt":[[408,1422],[556,1422],[556,1463],[408,1463]],"region":{"top_left_x":408,"top_left_y":1422,"width":149,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ce9d28ab9c749fd9460cdc35e622a80","type":"text","conversion_output":true,"text":"screening.","text_display":" screening.","confidence":1,"confidence_rate":1},{"cnt":[[374,1461],[2325,1461],[2325,1502],[374,1502]],"region":{"top_left_x":373,"top_left_y":1460,"width":1952,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15d869a168154281b6055536300cf883","type":"text","conversion_output":true,"text":"\\({ }^{\\text {o }}\\) Adverse event assessments will be performed during study drug administration; at \\(22-36\\) hours after study drug administration; on Days 5,30,","text_display":"\n\\({ }^{\\text {o }}\\) Adverse event assessments will be performed during study drug administration; at \\(22-36\\) hours after study drug administration; on Days 5,30,","confidence":0.42654306348251625,"confidence_rate":0.9946888918998115},{"cnt":[[408,1500],[2370,1500],[2370,1540],[408,1540]],"region":{"top_left_x":408,"top_left_y":1499,"width":1962,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4455f2132ebc4ab5ba7221781b0242ac","type":"text","conversion_output":true,"text":"and 90 (may be done via telephone interview if necessary), and at early discontinuation. Refer to Section 5.3.1 (Adverse Event Reporting Period)","text_display":" and 90 (may be done via telephone interview if necessary), and at early discontinuation. Refer to Section 5.3.1 (Adverse Event Reporting Period)","confidence":0.9990234375,"confidence_rate":0.9999935721282389},{"cnt":[[408,1538],[655,1538],[655,1575],[408,1575]],"region":{"top_left_x":408,"top_left_y":1538,"width":248,"height":37},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"834850e5b967489a8a34c60fdd0e6de7","type":"text","conversion_output":true,"text":"for further details.","text_display":" for further details.","confidence":1,"confidence_rate":1},{"cnt":[[374,1783],[780,1783],[780,1828],[374,1828]],"region":{"top_left_x":373,"top_left_y":1783,"width":407,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1a8ff045d2342a9942d518975a5d31e","type":"section_header","conversion_output":false,"children_ids":["f983016718904db28fc5e45c0a1285e0"],"text":"","text_display":""},{"cnt":[[376,1788],[776,1788],[776,1824],[376,1824]],"region":{"top_left_x":375,"top_left_y":1787,"width":401,"height":38},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f983016718904db28fc5e45c0a1285e0","type":"text","conversion_output":true,"parent_id":"e1a8ff045d2342a9942d518975a5d31e","text":"Alteplase-Genentech, Inc.","text_display":"\n\n\\section*{Alteplase-Genentech, Inc.}","confidence":0.9936609268188477,"confidence_rate":0.999788047451091},{"cnt":[[378,1822],[819,1822],[819,1858],[378,1858]],"region":{"top_left_x":378,"top_left_y":1821,"width":441,"height":38},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd61d29c58574dbd94a8b6ee6cf34b1b","type":"text","conversion_output":true,"text":"72/Protocol ML29093, Version 3","text_display":"\n\n72/Protocol ML29093, Version 3","confidence":1,"confidence_rate":1},{"cnt":[[370,1946],[1420,1946],[1420,1992],[370,1992]],"region":{"top_left_x":369,"top_left_y":1946,"width":1052,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"381c1bd8098a4ef7bc2117170aa8dc50","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9956102357245982,"confidence_rate":0.9999323187892346},{"cnt":[[370,1985],[694,1985],[694,2017],[370,2017]],"region":{"top_left_x":369,"top_left_y":1985,"width":325,"height":33},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d71f3c2d860b42d9827785261f4e6082","type":"page_info","conversion_output":false,"text":"617/aCSR 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Administration}","confidence":0.99609375,"confidence_rate":0.9998650470614108},{"cnt":[[451,490],[810,490],[810,552],[451,552]],"region":{"top_left_x":451,"top_left_y":489,"width":359,"height":64},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f21ef252524f4d759d09e809611e7ae0","type":"section_header","conversion_output":false,"children_ids":["41c5a10e0aa144978b8122cbdf8bd392"],"text":"","text_display":""},{"cnt":[[455,505],[804,505],[804,546],[455,546]],"region":{"top_left_x":455,"top_left_y":504,"width":349,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41c5a10e0aa144978b8122cbdf8bd392","type":"text","conversion_output":true,"parent_id":"f21ef252524f4d759d09e809611e7ae0","text":"Administration of bolus","text_display":"\n\n\\section*{Administration of 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administration","confidence":1,"confidence_rate":1},{"cnt":[[559,1212],[655,1212],[655,1253],[559,1253]],"region":{"top_left_x":558,"top_left_y":1211,"width":98,"height":42},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4569c314c5bc49ff97e2e28dbdb88d03","type":"text","conversion_output":true,"text":"Step 2:","text_display":"\n\nStep 2:","confidence":1,"confidence_rate":1},{"cnt":[[597,1255],[797,1255],[797,1291],[597,1291]],"region":{"top_left_x":597,"top_left_y":1254,"width":201,"height":38},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d3a166ee512f48a2a80dc775053c37d3","type":"text","conversion_output":true,"text":"Discard excess","text_display":"\nDiscard excess","confidence":0.99951171875,"confidence_rate":0.999974295041004},{"cnt":[[597,1285],[1738,1285],[1738,1321],[597,1321]],"region":{"top_left_x":597,"top_left_y":1284,"width":1142,"height":38},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b6653acb4beb4c6aa03e9b78e9740102","type":"text","conversion_output":true,"text":"To ensure proper dosing, discard excess by removing from vial any quantity of drug in excess of that","text_display":"\nTo ensure proper dosing, discard excess by removing from vial any quantity of drug in excess of that","confidence":1,"confidence_rate":1},{"cnt":[[597,1315],[1745,1315],[1745,1351],[597,1351]],"region":{"top_left_x":597,"top_left_y":1314,"width":1148,"height":38},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ed239e3fdf684fee86de76a093e9570d","type":"text","conversion_output":true,"text":"specified for patient treatment. When drawing off excess solution, be sure to insert the needle into the","text_display":" specified for patient treatment. When drawing off excess solution, be sure to insert the needle into the","confidence":1,"confidence_rate":1},{"cnt":[[597,1345],[1601,1345],[1601,1381],[597,1381]],"region":{"top_left_x":597,"top_left_y":1344,"width":1004,"height":38},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b3e4d5671f6a483788089eff851a6055","type":"text","conversion_output":true,"text":"peripheral area of the vial top, away from the puncture site caused by the transfer device","text_display":" peripheral area of the vial top, away from the puncture site caused by the transfer device","confidence":1,"confidence_rate":1},{"cnt":[[559,1401],[655,1401],[655,1442],[559,1442]],"region":{"top_left_x":558,"top_left_y":1400,"width":98,"height":42},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9696191ca46b4c2c9b4681153bd8aaf6","type":"text","conversion_output":true,"text":"Step 3:","text_display":"\n\nStep 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Remove from port (second injection site) on infusion line after infusion set is primed, or","confidence":0.8534503650153056,"confidence_rate":0.9983676441251178},{"cnt":[[503,1611],[1343,1611],[1343,1656],[503,1656]],"region":{"top_left_x":502,"top_left_y":1611,"width":841,"height":46},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cb16ff5d02ec4ea3b3ca49f7c228134a","type":"text","conversion_output":true,"text":"- Program infusion pump to deliver bolus at infusion initiation","text_display":"\n- Program infusion pump to deliver bolus at infusion initiation","confidence":0.8671875,"confidence_rate":0.9979066050579746},{"cnt":[[559,1659],[655,1659],[655,1695],[559,1695]],"region":{"top_left_x":558,"top_left_y":1658,"width":98,"height":38},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c49b37ea5b3d45eb9c3f1aeb89f5ace6","type":"text","conversion_output":true,"text":"Step 4:","text_display":"\n\nStep 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minutes.","confidence":0.6915183254750445,"confidence_rate":0.9953416985449008},{"cnt":[[455,1910],[1571,1910],[1571,1953],[455,1953]],"region":{"top_left_x":455,"top_left_y":1909,"width":1116,"height":44},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"867f9b3689d94b1db886ae298c979240","type":"text","conversion_output":true,"text":"50-mg vials-Administer using either a polyvinyl chloride bag or glass vial and infusion set.","text_display":"\n50-mg vials-Administer using either a polyvinyl chloride bag or glass vial and infusion set.","confidence":0.99658203125,"confidence_rate":0.9999647034750034},{"cnt":[[455,2110],[1429,2110],[1429,2155],[455,2155]],"region":{"top_left_x":455,"top_left_y":2109,"width":974,"height":46},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"36bb3a61d52e4dfd835fd4ab1a5275b9","type":"text","conversion_output":true,"text":"No medication should be added to the infusion solutions that contain alteplase.","text_display":"\n\nNo medication should be added to the infusion solutions that contain alteplase.","confidence":1,"confidence_rate":1},{"cnt":[[455,2170],[1712,2170],[1712,2215],[455,2215]],"region":{"top_left_x":455,"top_left_y":2169,"width":1258,"height":47},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e09525c7ed9b4a1c97a712944da8d7f2","type":"text","conversion_output":true,"text":"For specifics regarding dosing and administration, please see the Activase full Prescribing Information.","text_display":"\nFor specifics regarding dosing and administration, please see the Activase full Prescribing Information.","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[455,2376],[862,2376],[862,2417],[455,2417]],"region":{"top_left_x":455,"top_left_y":2376,"width":407,"height":41},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f7ab228bf8b4afe96479573492656e8","type":"text","conversion_output":true,"text":"Alteplase-Genentech, Inc.","text_display":"\n\nAlteplase-Genentech, Inc.","confidence":0.9980480668600649,"confidence_rate":0.9999348740993154},{"cnt":[[455,2411],[904,2411],[904,2451],[455,2451]],"region":{"top_left_x":455,"top_left_y":2410,"width":450,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"323f42ca417d4b019f7e9da7ce5923c1","type":"text","conversion_output":true,"text":"73/Protocol ML29093, Version 3","text_display":"\n73/Protocol ML29093, Version 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ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-283","page":283,"lines":[{"cnt":[[812,374],[1422,374],[1422,475],[812,475]],"region":{"top_left_x":812,"top_left_y":373,"width":611,"height":102},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"516f3a580910468db368778157a10e17","type":"section_header","conversion_output":false,"children_ids":["cca60d47e9bc4c96a7400b80653a21a1","b83f426fd0cd492f8c7fa518ba6d66fd"],"text":"","text_display":""},{"cnt":[[984,378],[1218,378],[1218,428],[984,428]],"region":{"top_left_x":983,"top_left_y":378,"width":236,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cca60d47e9bc4c96a7400b80653a21a1","type":"text","conversion_output":true,"parent_id":"516f3a580910468db368778157a10e17","text":"Appendix 3","text_display":"\n\n\\section*{Appendix 3","confidence":1,"confidence_rate":1},{"cnt":[[816,421],[1418,421],[1418,471],[816,471]],"region":{"top_left_x":816,"top_left_y":421,"width":602,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b83f426fd0cd492f8c7fa518ba6d66fd","type":"text","conversion_output":true,"parent_id":"516f3a580910468db368778157a10e17","text":"Reconstitution of \\(5 0 - m g\\) Vials","text_display":" \\\\ Reconstitution of \\(5 0 - m g\\) Vials}","confidence":0.5145691322367805,"confidence_rate":0.9846670131573302},{"cnt":[[460,494],[1755,494],[1755,531],[460,531]],"region":{"top_left_x":459,"top_left_y":494,"width":1297,"height":37},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"337ea7401d744f598b88da7738fb73fd","type":"text","conversion_output":true,"text":"A single \\(50- mg\\) vial of Activase may be used to treat patients weighing up to 122 lbs or 55.5 kilograms. Reconstitute","text_display":"\n\nA single \\(50- mg\\) vial of Activase may be used to treat patients weighing up to 122 lbs or 55.5 kilograms. Reconstitute","confidence":0.9892780780792236,"confidence_rate":0.9999201526996633},{"cnt":[[460,529],[1751,529],[1751,561],[460,561]],"region":{"top_left_x":459,"top_left_y":528,"width":1292,"height":33},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9636e518bc3748d5acc4fbb80ccf8c05","type":"text","conversion_output":true,"text":"Activase immediately before administration, using aseptic technique at all times-including thorough hand washing","text_display":" Activase immediately before administration, using aseptic technique at all times-including thorough hand washing","confidence":0.9980475902557373,"confidence_rate":0.9999832965653107},{"cnt":[[460,559],[715,559],[715,591],[460,591]],"region":{"top_left_x":459,"top_left_y":558,"width":257,"height":33},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d9cc115e20f04c3f9a5734cc45d3dde1","type":"text","conversion_output":true,"text":"and the use of gloves.","text_display":" and the use of gloves.","confidence":1,"confidence_rate":1},{"cnt":[[559,1091],[655,1091],[655,1137],[559,1137]],"region":{"top_left_x":558,"top_left_y":1091,"width":98,"height":46},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d84006a1e01445c1915ccb07868f318f","type":"section_header","conversion_output":false,"children_ids":["b65a789f39d94a0d9e80f9fc3556efdf"],"text":"","text_display":""},{"cnt":[[563,1096],[651,1096],[651,1132],[563,1132]],"region":{"top_left_x":562,"top_left_y":1095,"width":89,"height":38},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b65a789f39d94a0d9e80f9fc3556efdf","type":"text","conversion_output":true,"parent_id":"d84006a1e01445c1915ccb07868f318f","text":"Step 1:","text_display":"\n\n\\section*{Step 1:}","confidence":1,"confidence_rate":1},{"cnt":[[597,1141],[1742,1141],[1742,1175],[597,1175]],"region":{"top_left_x":597,"top_left_y":1140,"width":1146,"height":36},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1ac70bee0d5b4e46af559176b53f8b17","type":"text","conversion_output":true,"text":"Assemble the \\(50- mg\\) vial of Actixase, the vial of Sterile Water for Injection (SWFI), USP (included with","text_display":"\n\nAssemble the \\(50- mg\\) vial of Actixase, the vial of Sterile Water for Injection (SWFI), USP (included with","confidence":0.9238650798797607,"confidence_rate":0.9993055987919767},{"cnt":[[597,1173],[1742,1173],[1742,1205],[597,1205]],"region":{"top_left_x":597,"top_left_y":1173,"width":1146,"height":33},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"560dffc5254c4140abfc92c8fedc2dbb","type":"text","conversion_output":true,"text":"the Activase package), a \\(50- mL\\) syringe, a large-bore needle (eg, 18-gauge), and alcohol wipes.Also,","text_display":" the Activase package), a \\(50- mL\\) syringe, a large-bore needle (eg, 18-gauge), and alcohol wipes.Also,","confidence":0.6024746683579327,"confidence_rate":0.9954041419822601},{"cnt":[[597,1199],[1399,1199],[1399,1231],[597,1231]],"region":{"top_left_x":597,"top_left_y":1198,"width":802,"height":34},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"78df95bdd5644a768c7491223d176cb1","type":"text","conversion_output":true,"text":"prepare a polyvinyl chloride bag or glass vial along with an infusion set","text_display":" prepare a polyvinyl chloride bag or glass vial along with an infusion set","confidence":0.9990234375,"confidence_rate":0.9999874739291208},{"cnt":[[559,1250],[655,1250],[655,1296],[559,1296]],"region":{"top_left_x":558,"top_left_y":1250,"width":98,"height":46},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3ab22c3b02dc48419960ef9ee3d01f3b","type":"section_header","conversion_output":false,"children_ids":["89c712c294b746dcb0baaf4865d92153"],"text":"","text_display":""},{"cnt":[[563,1259],[651,1259],[651,1291],[563,1291]],"region":{"top_left_x":562,"top_left_y":1258,"width":89,"height":34},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"89c712c294b746dcb0baaf4865d92153","type":"text","conversion_output":true,"parent_id":"3ab22c3b02dc48419960ef9ee3d01f3b","text":"Step 2:","text_display":"\n\n\\section*{Step 2:}","confidence":1,"confidence_rate":1},{"cnt":[[597,1300],[1755,1300],[1755,1334],[597,1334]],"region":{"top_left_x":597,"top_left_y":1299,"width":1159,"height":36},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0b17df861ee04e6d86a7df87ca09a599","type":"text","conversion_output":true,"text":"Remove the protective cap from the top of the Activase vial and the vial of SWFI. Swab the top of each","text_display":"\n\nRemove the protective cap from the top of the Activase vial and the vial of SWFI. Swab the top of each","confidence":1,"confidence_rate":1},{"cnt":[[597,1332],[1278,1332],[1278,1364],[597,1364]],"region":{"top_left_x":597,"top_left_y":1332,"width":682,"height":33},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f3ab290cfdd3474cb1a7929a1551ffe5","type":"text","conversion_output":true,"text":"vial with an alcohol wipe to reduce the risk of contamination","text_display":" vial with an alcohol wipe to reduce the risk of contamination","confidence":1,"confidence_rate":1},{"cnt":[[559,1388],[655,1388],[655,1429],[559,1429]],"region":{"top_left_x":558,"top_left_y":1387,"width":98,"height":42},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"dbf1cf4de7614e42b3623bf2c6faa6d6","type":"section_header","conversion_output":false,"children_ids":["9848135982c6407f9ff7ba3944fa39d1"],"text":"","text_display":""},{"cnt":[[563,1392],[651,1392],[651,1424],[563,1424]],"region":{"top_left_x":562,"top_left_y":1392,"width":89,"height":33},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9848135982c6407f9ff7ba3944fa39d1","type":"text","conversion_output":true,"parent_id":"dbf1cf4de7614e42b3623bf2c6faa6d6","text":"Step 3:","text_display":"\n\n\\section*{Step 3:}","confidence":1,"confidence_rate":1},{"cnt":[[597,1431],[1764,1431],[1764,1463],[597,1463]],"region":{"top_left_x":597,"top_left_y":1430,"width":1167,"height":34},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1ae6cb8711014321a703384a0897b662","type":"text","conversion_output":true,"text":"Withdraw \\(50- mL\\) of SWFI, without preservatives. Diluent is included. DO NOT USE Bacteriostatic Water","text_display":"\n\nWithdraw \\(50- mL\\) of SWFI, without preservatives. Diluent is included. DO NOT USE Bacteriostatic Water","confidence":0.9956104733286111,"confidence_rate":0.9999600081730661},{"cnt":[[597,1457],[806,1457],[806,1493],[597,1493]],"region":{"top_left_x":597,"top_left_y":1456,"width":209,"height":38},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2b299686a22c453b9c79ab3565855282","type":"text","conversion_output":true,"text":"for Injection, USP","text_display":" for Injection, USP","confidence":1,"confidence_rate":1},{"cnt":[[559,1517],[655,1517],[655,1558],[559,1558]],"region":{"top_left_x":558,"top_left_y":1516,"width":98,"height":42},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9e4892a58aa3443596042249d458d614","type":"section_header","conversion_output":false,"children_ids":["da6571e2923240b5b72364ee4cde30c2"],"text":"","text_display":""},{"cnt":[[563,1521],[651,1521],[651,1553],[563,1553]],"region":{"top_left_x":562,"top_left_y":1521,"width":89,"height":33},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"da6571e2923240b5b72364ee4cde30c2","type":"text","conversion_output":true,"parent_id":"9e4892a58aa3443596042249d458d614","text":"Step 4:","text_display":"\n\n\\section*{Step 4:}","confidence":1,"confidence_rate":1},{"cnt":[[597,1564],[1772,1564],[1772,1596],[597,1596]],"region":{"top_left_x":597,"top_left_y":1564,"width":1176,"height":33},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"805f722b92fd4065b2c772f03540a9a1","type":"text","conversion_output":true,"text":"Inject the \\(50- mL\\) into the \\(50- mg\\) Activase vial using a large-bore needle and syringe, directing the stream","text_display":"\n\nInject the \\(50- mL\\) into the \\(50- mg\\) Activase vial using a large-bore needle and syringe, directing the stream","confidence":0.998046875,"confidence_rate":0.9999839752526943},{"cnt":[[597,1590],[1714,1590],[1714,1622],[597,1622]],"region":{"top_left_x":597,"top_left_y":1589,"width":1118,"height":34},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7eb1d0d489034d729fbbefe65f2afc75","type":"text","conversion_output":true,"text":"into the lyophilized cake. DO NOT USE IF VACUUM IS NOT PRESENT. The syringe should not be","text_display":" into the lyophilized cake. DO NOT USE IF VACUUM IS NOT PRESENT. The syringe should not be","confidence":0.9960966110229492,"confidence_rate":0.9999583941944539},{"cnt":[[597,1620],[1755,1620],[1755,1652],[597,1652]],"region":{"top_left_x":597,"top_left_y":1619,"width":1159,"height":34},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d412ed961cd44764852f896b6eef6289","type":"text","conversion_output":true,"text":"primed with air during preparation and should be inserted into the Activase vial stopper. Slight foaming","text_display":" primed with air during preparation and should be inserted into the Activase vial stopper. Slight foaming","confidence":0.9970703125,"confidence_rate":0.9999730830463522},{"cnt":[[597,1650],[1747,1650],[1747,1682],[597,1682]],"region":{"top_left_x":597,"top_left_y":1650,"width":1150,"height":33},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f7351cd4fda448d8b82e8983f7381692","type":"text","conversion_output":true,"text":"upon reconstitution is normal. Let the solution stand undisturbed for several minutes to allow any large","text_display":" upon reconstitution is normal. Let the solution stand undisturbed for several minutes to allow any large","confidence":1,"confidence_rate":1},{"cnt":[[597,1680],[836,1680],[836,1712],[597,1712]],"region":{"top_left_x":597,"top_left_y":1680,"width":239,"height":33},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"911c1b3ba06c412ab8cdb6700d4cbea6","type":"text","conversion_output":true,"text":"bubbles to dissipate","text_display":" bubbles to dissipate","confidence":1,"confidence_rate":1},{"cnt":[[559,1732],[655,1732],[655,1777],[559,1777]],"region":{"top_left_x":558,"top_left_y":1731,"width":98,"height":46},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"70aa8aa6ed90449cac1ca15a721c72e4","type":"section_header","conversion_output":false,"children_ids":["f9216d96b5094a54a2d0078a50006558"],"text":"","text_display":""},{"cnt":[[563,1736],[651,1736],[651,1772],[563,1772]],"region":{"top_left_x":562,"top_left_y":1735,"width":89,"height":38},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f9216d96b5094a54a2d0078a50006558","type":"text","conversion_output":true,"parent_id":"70aa8aa6ed90449cac1ca15a721c72e4","text":"Step 5:","text_display":"\n\n\\section*{Step 5:}","confidence":1,"confidence_rate":1},{"cnt":[[597,1777],[1721,1777],[1721,1811],[597,1811]],"region":{"top_left_x":597,"top_left_y":1776,"width":1124,"height":36},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"39bbb7cc8fee451ba0de176fe6595aab","type":"text","conversion_output":true,"text":"Mix with a gentle swirl or slow inversion. 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ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-287","page":287,"lines":[{"cnt":[[490,372],[1740,372],[1740,513],[490,513]],"region":{"top_left_x":489,"top_left_y":371,"width":1252,"height":143},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e12b9f3afe4a4e6582fe00ca01d32c8f","type":"title","conversion_output":false,"children_ids":["ff41a2f9cf374926ac6739093a91c548","f740880a68c841e9afa23cae1763ac26","8eb06382a3354d6eade4dc8ae30306a0"],"text":"","text_display":""},{"cnt":[[980,378],[1218,378],[1218,428],[980,428]],"region":{"top_left_x":979,"top_left_y":378,"width":240,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff41a2f9cf374926ac6739093a91c548","type":"text","conversion_output":true,"parent_id":"e12b9f3afe4a4e6582fe00ca01d32c8f","text":"Appendix 6","text_display":"\n\n\\title{\nAppendix 6","confidence":1,"confidence_rate":1},{"cnt":[[498,421],[1734,421],[1734,471],[498,471]],"region":{"top_left_x":498,"top_left_y":421,"width":1236,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f740880a68c841e9afa23cae1763ac26","type":"text","conversion_output":true,"parent_id":"e12b9f3afe4a4e6582fe00ca01d32c8f","text":"Center for Epidemiologic Studies, Depression (CES-D) Scale,","text_display":" \\\\ Center for Epidemiologic Studies, Depression (CES-D) Scale,","confidence":0.9956097602844238,"confidence_rate":0.9999312538456676},{"cnt":[[1061,468],[1175,468],[1175,505],[1061,505]],"region":{"top_left_x":1061,"top_left_y":468,"width":115,"height":37},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8eb06382a3354d6eade4dc8ae30306a0","type":"text","conversion_output":true,"parent_id":"e12b9f3afe4a4e6582fe00ca01d32c8f","text":"NIMH","text_display":" NIMH\n}","confidence":1,"confidence_rate":1},{"cnt":[[468,546],[1781,546],[1781,578],[468,578]],"region":{"top_left_x":468,"top_left_y":545,"width":1314,"height":33},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3eca49c5374f4b3b8d9accc9b8bb7c25","type":"text","conversion_output":true,"text":"Below is a list of the ways you might have felt or behaved. Please tell me how often you have felt this way during the past week.","text_display":"\n\nBelow is a list of the ways you might have felt or behaved. Please tell me how often you have felt this way during the past 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\\multirow{3}{*}{} & \\multicolumn{4}{|c|}{During the Past} \\\\\n\\hline & \\multicolumn{4}{|l|}{Week} \\\\\n\\hline & Rarely or none of the time (less than 1 day) & Some or a little of the time (1-2 days) & Occasionally or a moderate amount of time (3-4 days) & Most or all of the time (5-7 days) \\\\\n\\hline 1. I was bothered by things that usually don't bother me. & □ & □ & □ & □ \\\\\n\\hline 2. I did not feel like eating; my appetite was poor. & □ & □ & □ & □ \\\\\n\\hline 3. I felt that I could not shake off the blues even with help from my family or friends. & □ & □ & □ & □ \\\\\n\\hline 4. I felt I was just as good as other people. & □ & □ & □ & □ \\\\\n\\hline 5. I had trouble keeping my mind on what I was doing. & □ & □ & □ & □ \\\\\n\\hline 6. I felt depressed. & □ & □ & □ & □ \\\\\n\\hline 7. I felt that everything I did was an effort. & □ & □ & □ & □ \\\\\n\\hline 8. I felt hopeful about the future. & □ & □ & □ & □ \\\\\n\\hline 9. I thought my life had been a failure. & □ & □ & □ & □ \\\\\n\\hline 10. I felt fearful. & □ & □ & □ & □ \\\\\n\\hline 11. My sleep was restless. & □ & □ & □ & □ \\\\\n\\hline 12. I was happy. & □ & □ & □ & □ \\\\\n\\hline 13. I talked less than usual. & □ & □ & □ & □ \\\\\n\\hline 14. I felt lonely. & □ & □ & □ & □ \\\\\n\\hline 15. People were unfriendly. & □ & □ & □ & □ \\\\\n\\hline 16. I enjoyed life. & □ & □ & □ & □ \\\\\n\\hline 17. I had crying spells. & □ & □ & □ & □ \\\\\n\\hline 18. I felt sad. & □ & □ & □ & □ \\\\\n\\hline 19. I felt that people dislike me. & □ & □ & □ & □ \\\\\n\\hline 20. I could not get \"going.\" & □ & □ & □ & □ \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multirow{3}{*}{} & \\multicolumn{4}{|c|}{During the Past} \\\\\n\\hline & \\multicolumn{4}{|l|}{Week} \\\\\n\\hline & Rarely or none of the time (less than 1 day) & Some or a little of the time (1-2 days) & Occasionally or a moderate amount of time (3-4 days) & Most or all of the time (5-7 days) \\\\\n\\hline 1. I was bothered by things that usually don't bother me. & □ & □ & □ & □ \\\\\n\\hline 2. I did not feel like eating; my appetite was poor. & □ & □ & □ & □ \\\\\n\\hline 3. I felt that I could not shake off the blues even with help from my family or friends. & □ & □ & □ & □ \\\\\n\\hline 4. I felt I was just as good as other people. & □ & □ & □ & □ \\\\\n\\hline 5. I had trouble keeping my mind on what I was doing. & □ & □ & □ & □ \\\\\n\\hline 6. I felt depressed. & □ & □ & □ & □ \\\\\n\\hline 7. I felt that everything I did was an effort. & □ & □ & □ & □ \\\\\n\\hline 8. I felt hopeful about the future. & □ & □ & □ & □ \\\\\n\\hline 9. I thought my life had been a failure. & □ & □ & □ & □ \\\\\n\\hline 10. I felt fearful. & □ & □ & □ & □ \\\\\n\\hline 11. My sleep was restless. & □ & □ & □ & □ \\\\\n\\hline 12. I was happy. & □ & □ & □ & □ \\\\\n\\hline 13. I talked less than usual. & □ & □ & □ & □ \\\\\n\\hline 14. I felt lonely. & □ & □ & □ & □ \\\\\n\\hline 15. People were unfriendly. & □ & □ & □ & □ \\\\\n\\hline 16. I enjoyed life. & □ & □ & □ & □ \\\\\n\\hline 17. I had crying spells. & □ & □ & □ & □ \\\\\n\\hline 18. I felt sad. & □ & □ & □ & □ \\\\\n\\hline 19. I felt that people dislike me. & □ & □ & □ & □ \\\\\n\\hline 20. 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Possible range of scores is zero to 60 , with the higher","confidence":0.54296875,"confidence_rate":0.9955522308889134},{"cnt":[[473,1908],[1051,1908],[1051,1940],[473,1940]],"region":{"top_left_x":472,"top_left_y":1907,"width":579,"height":34},"line":252,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c531960b95c3424f8c9cdf3bd7861195","type":"text","conversion_output":true,"text":"scores indicating the presence of more symptomatology.","text_display":" scores indicating the presence of more symptomatology.","confidence":1,"confidence_rate":1},{"cnt":[[460,2376],[853,2376],[853,2413],[460,2413]],"region":{"top_left_x":459,"top_left_y":2376,"width":394,"height":37},"line":253,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87937a679f0540288b7bbcc2e80e847b","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9980475902557373,"confidence_rate":0.9999348581824669},{"cnt":[[460,2413],[896,2413],[896,2447],[460,2447]],"region":{"top_left_x":459,"top_left_y":2412,"width":437,"height":36},"line":254,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd199894e56840b7b1f5410ac77a5567","type":"page_info","conversion_output":false,"text":"78/Protocol ML29093, Version 3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":255,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e6df1a982594fdcb94ccde2ca6beaf8","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922086966757888,"confidence_rate":0.9998796716383385},{"cnt":[[370,2608],[694,2608],[694,2643],[370,2643]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":35},"line":256,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91127049a2284fe2b9a6de8b62e4d1e6","type":"page_info","conversion_output":false,"text":"623/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-288","page":288,"lines":[{"cnt":[[612,378],[1622,378],[1622,477],[612,477]],"region":{"top_left_x":612,"top_left_y":378,"width":1011,"height":99},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bceca80f617477b82c2c0cfa6f4201b","type":"figure_label","conversion_output":false,"children_ids":["a4777a3b7886438a894a49ed1f8e472d","c8e78e1a678340468bf3aaef8b3f4946"],"text":"","text_display":""},{"cnt":[[984,382],[1218,382],[1218,428],[984,428]],"region":{"top_left_x":983,"top_left_y":382,"width":236,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4777a3b7886438a894a49ed1f8e472d","type":"text","conversion_output":false,"parent_id":"3bceca80f617477b82c2c0cfa6f4201b","text":"Appendix 7","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[614,423],[1618,423],[1618,471],[614,471]],"region":{"top_left_x":614,"top_left_y":423,"width":1004,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8e78e1a678340468bf3aaef8b3f4946","type":"text","conversion_output":false,"parent_id":"3bceca80f617477b82c2c0cfa6f4201b","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":"","confidence":0.9892807006835938,"confidence_rate":0.999804070743993},{"cnt":[[468,494],[1790,494],[1790,1970],[468,1970]],"region":{"top_left_x":468,"top_left_y":494,"width":1322,"height":1477},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"214aacfa90e24060a843cd0a7364984d","type":"table","conversion_output":true,"children_ids":["de9cace5f3a744dfb10c28863e057960","06eef9e45ba7422cbd7f94adf26f5788","4e15a5d27c1149dd90e6b7748049929b","47fb7d77f9ed4d2fbb93fb5ba8034ad2","f6bc9c50c3b74fee86b6c7e1da0336e8","458a6b1592a54bdea04b70d252f614e0","2d4cdce4b91944ebb9bfa70f10945f46","485235a71ede4ddda6a14bcd6d6faa48","d3be6f214dbf4a34bc1f800c5e1b28e9","b7076364081a4c678808217f6d0cf466","79c958957c04472f9eef4b8b2b21d878","1760083abeef4c5e863710d4660c9a1b","3ded1cf6e5194ab3abc585ffa4cc604f","96a9fe8e76314bd89746633e842e9316","9b8233ec6ff04522a974fd0ffa074f42","dbe44294219b4368a34e214e806d20d6","68a43c22d4ed4c6a843bfb909e64ca50","f086b74320bc4725bfd7e151aa3ecfb3","eb3ed29a774547eab0e2cbacdd3be70d","92f74aec792445c2b00978041403fedf","69d74b81456843f5b83bf023cf549886","7ac56fb90dcf46fcb2ebc5167e0e58e5","89d4c1bc0a0b4882a39b902eb2ff4da1","f94c792c7c4f4a9fb7c66f724b56c53c","cf655c0cd663403cb89b2f2508f3b657"],"selected_labels":["3bceca80f617477b82c2c0cfa6f4201b"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|l|}{Administer stroke scale items in the order listed. Record performance in each category aher each subscale exam. Do not go back and change scores. Follow directions provided for each exam technique. Scores should reflect what the patent does, not what the clinician thinks the patient can do. The dinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be coached (i.e., repeated requests to patient to make a special effort),} \\\\\n\\hline 1 & Has the subject had a stroke (either as the index event at randomization or as an outcome event)? If no, form is complete. & ◯ No\n◯ Yes \\\\\n\\hline 2 & \\begin{tabular}{l}\n(1a) Level of Consciousness \\\\\nThe investigator most choose a response, even if a ful evaluaton is prevented by such costacies as an endotracheal tute, language bamier, orotracheal traumabandages. A 3 is sooved only if the patient makes no movement (other than reflexive posturing) in response to noxlous stimulation. Coma score \\({ }^{+} 3^{+}\\).\n\\end{tabular} & ◯ 0=Alert; keenly responsive\n◯ \\(1=\\) Not alert, but arousable by minor stimulation to obey, answer or respond\n◯ \\(2=\\) Not alert, requires repeated stimulation to attend, or is obtunded and requires strong or painful stimulation to make movements (not stereotyped)\n◯ 3=Responds only with reflex motor or autonomic effects or totally unresponsive, flaccid, areflexic (Complete form using coma scoring) \\\\\n\\hline 3 & \\begin{tabular}{l}\n(1b) LOC Questions \\\\\nThe pabent is assed the month and his/her age. The answer must be correct - There is no partial creatif for being close. Aphasic and stuporous pasents who do not comprenend the questons will scope 2 . Patients unable to speas. because of endotracheal intubation, orotracheal trauma, severe dysartina from any cause, language barrer or any other probiem not secondary to aphasia are given a 1. It is important that only the inital answer be graded and that the examiner not \"helo\" the patient with verbal or non-vertal cues. Coma score \"2\"\n\\end{tabular} & ◯ \\(0=\\) Answers both questions correctly\n◯ 1=Answers one question correctly\n◯ 2=Answers neither question correctly \\\\\n\\hline 4 & \\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and ciose the eyes and then to gro and release the non-paretic nand. Substitute another one step command if the hands cannot De used. Credit is given if an unequivocal autempt is mace but not completed due to weakness. If the pasent does not respond to commund, the task should be demonstrated to them (partomine) and score the result (i.e. folows none, one or too commands) Patients with trauma, amputaton, or other physical impediments should be given subable cne-step communds. Ony the frost attenpt is scored. Coms score \"2\".\n\\end{tabular} & ◯ 0=Performs both tasks correctly\n◯ 1=Performs one task correctly\n◯ 2=Performs neither task correctly \\\\\n\\hline 5 & \\begin{tabular}{l}\n(2) Best Gaze \\\\\nOny horizontal eye movements will be tested. Voluntary or reflexte (Douldocephalle) eye movements will be scored but calonc testing is not done. If the patient has a confugate deviaton of the eyes trut can be overcome by voluntarly of reflexter activity, the score will be 1. F a patent has an solated pertpheral neve paresis (CN III, IV or VI) score a 1. Gaze is testable in all aphasio patents. Pacents alth ocular trauma, bandages, pre-evisting \\\\\n![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-288.jpg?height=22\\&width=564\\&top_left_y=1852\\&top_left_x=563) refexive movements and a choice made by the investigator. Estabiling eye contact and then moving aoout the pattent from sole to side will occasionaly darity the presence of a partal gaze paisy. Coma score as examined.\n\\end{tabular} & ◯ 0=Normal\n◯ \\(1=\\) Partial gaze palsy. This score is given when gaze is abnormal in one or both eyes, but where forced deviation or total gaze paresis are not present\n◯ \\(2=\\) Forced deviation, or total gaze paresis not overcome by the oculocephalic maneuver \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Appendix 7\nNational Institutes of Health Stroke Scale (NIHSS)}\n\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|l|}{Administer stroke scale items in the order listed. Record performance in each category aher each subscale exam. Do not go back and change scores. Follow directions provided for each exam technique. Scores should reflect what the patent does, not what the clinician thinks the patient can do. The dinician should record answers while administering the exam and work quickly. Except where indicated, the patient should not be coached (i.e., repeated requests to patient to make a special effort),} \\\\\n\\hline 1 & Has the subject had a stroke (either as the index event at randomization or as an outcome event)? If no, form is complete. & ◯ No\n◯ Yes \\\\\n\\hline 2 & \\begin{tabular}{l}\n(1a) Level of Consciousness \\\\\nThe investigator most choose a response, even if a ful evaluaton is prevented by such costacies as an endotracheal tute, language bamier, orotracheal traumabandages. A 3 is sooved only if the patient makes no movement (other than reflexive posturing) in response to noxlous stimulation. Coma score \\({ }^{+} 3^{+}\\).\n\\end{tabular} & ◯ 0=Alert; keenly responsive\n◯ \\(1=\\) Not alert, but arousable by minor stimulation to obey, answer or respond\n◯ \\(2=\\) Not alert, requires repeated stimulation to attend, or is obtunded and requires strong or painful stimulation to make movements (not stereotyped)\n◯ 3=Responds only with reflex motor or autonomic effects or totally unresponsive, flaccid, areflexic (Complete form using coma scoring) \\\\\n\\hline 3 & \\begin{tabular}{l}\n(1b) LOC Questions \\\\\nThe pabent is assed the month and his/her age. The answer must be correct - There is no partial creatif for being close. Aphasic and stuporous pasents who do not comprenend the questons will scope 2 . Patients unable to speas. because of endotracheal intubation, orotracheal trauma, severe dysartina from any cause, language barrer or any other probiem not secondary to aphasia are given a 1. It is important that only the inital answer be graded and that the examiner not \"helo\" the patient with verbal or non-vertal cues. Coma score \"2\"\n\\end{tabular} & ◯ \\(0=\\) Answers both questions correctly\n◯ 1=Answers one question correctly\n◯ 2=Answers neither question correctly \\\\\n\\hline 4 & \\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and ciose the eyes and then to gro and release the non-paretic nand. Substitute another one step command if the hands cannot De used. Credit is given if an unequivocal autempt is mace but not completed due to weakness. If the pasent does not respond to commund, the task should be demonstrated to them (partomine) and score the result (i.e. folows none, one or too commands) Patients with trauma, amputaton, or other physical impediments should be given subable cne-step communds. Ony the frost attenpt is scored. Coms score \"2\".\n\\end{tabular} & ◯ 0=Performs both tasks correctly\n◯ 1=Performs one task correctly\n◯ 2=Performs neither task correctly \\\\\n\\hline 5 & \\begin{tabular}{l}\n(2) Best Gaze \\\\\nOny horizontal eye movements will be tested. Voluntary or reflexte (Douldocephalle) eye movements will be scored but calonc testing is not done. If the patient has a confugate deviaton of the eyes trut can be overcome by voluntarly of reflexter activity, the score will be 1. F a patent has an solated pertpheral neve paresis (CN III, IV or VI) score a 1. Gaze is testable in all aphasio patents. Pacents alth ocular trauma, bandages, pre-evisting \\\\\n![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-288.jpg?height=22\\&width=564\\&top_left_y=1852\\&top_left_x=563) refexive movements and a choice made by the investigator. Estabiling eye contact and then moving aoout the pattent from sole to side will occasionaly darity the presence of a partal gaze paisy. Coma score as examined.\n\\end{tabular} & ◯ 0=Normal\n◯ \\(1=\\) Partial gaze palsy. 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obtunded","confidence":0.9603392948999954,"confidence_rate":0.9994457889087844},{"cnt":[[1221,954],[1768,954],[1768,981],[1221,981]],"region":{"top_left_x":1221,"top_left_y":953,"width":548,"height":29},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"21f0d4138a6d4259af8d437fe4a0504c","type":"text","conversion_output":false,"parent_id":"dbe44294219b4368a34e214e806d20d6","text":"and requires strong or painful stimulation to make movements","text_display":" and requires strong or painful stimulation to make movements","confidence":1,"confidence_rate":1},{"cnt":[[1221,980],[1377,980],[1377,1006],[1221,1006]],"region":{"top_left_x":1221,"top_left_y":979,"width":156,"height":27},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a74ac534fa3e4a16ae1f80fb07313768","type":"text","conversion_output":false,"parent_id":"dbe44294219b4368a34e214e806d20d6","text":"(not stereotyped)","text_display":" (not 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totally","confidence":0.99951171875,"confidence_rate":0.9999930228743673},{"cnt":[[1210,1042],[1735,1042],[1735,1071],[1210,1071]],"region":{"top_left_x":1210,"top_left_y":1042,"width":526,"height":30},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ceefb70609484e888f77436da89c7bfe","type":"text","conversion_output":false,"parent_id":"dbe44294219b4368a34e214e806d20d6","text":"unresponsive, flaccid, areflexic (Complete form using coma","text_display":" unresponsive, flaccid, areflexic (Complete form using coma","confidence":0.9951231479644775,"confidence_rate":0.9999224032856451},{"cnt":[[1210,1067],[1288,1067],[1288,1093],[1210,1093]],"region":{"top_left_x":1210,"top_left_y":1066,"width":78,"height":27},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9add0d7d144e49d69850c979dfd96f63","type":"text","conversion_output":false,"parent_id":"dbe44294219b4368a34e214e806d20d6","text":"scoring)","text_display":" 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LOC Questions \\\\\nThe pabent is assed the month and his/her age. The answer must be correct - There is no partial creatif for being close. Aphasic and stuporous pasents who do not comprenend the questons will scope 2 . Patients unable to speas. because of endotracheal intubation, orotracheal trauma, severe dysartina from any cause, language barrer or any other probiem not secondary to aphasia are given a 1. It is important that only the inital answer be graded and that the examiner not \"helo\" the patient with verbal or non-vertal cues. Coma score \"2\"\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(1b) LOC Questions \\\\\nThe pabent is assed the month and his/her age. The answer must be correct - There is no partial creatif for being close. Aphasic and stuporous pasents who do not comprenend the questons will scope 2 . Patients unable to speas. because of endotracheal intubation, orotracheal trauma, severe dysartina from any cause, language barrer or any other probiem not secondary to aphasia are given a 1. It is important that only the inital answer be graded and that the examiner not \"helo\" the patient with verbal or non-vertal cues. Coma score \"2\"\n\\end{tabular}","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.04090711024953595,"confidence_rate":0.9840889383709375},{"cnt":[[752,1154],[939,1154],[939,1183],[752,1183]],"region":{"top_left_x":751,"top_left_y":1154,"width":188,"height":29},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0c22c694702b4ef8b9b605a36aa3e31c","type":"text","conversion_output":false,"parent_id":"f086b74320bc4725bfd7e151aa3ecfb3","text":"(1b) LOC Questions","text_display":"(1b) LOC Questions","confidence":0.893606424331665,"confidence_rate":0.9951210780991776},{"cnt":[[550,1201],[1141,1201],[1141,1227],[550,1227]],"region":{"top_left_x":549,"top_left_y":1200,"width":592,"height":27},"line":55,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d8e02b27d264404aae98043f93454cb6","type":"text","conversion_output":false,"parent_id":"f086b74320bc4725bfd7e151aa3ecfb3","text":"The pabent is assed the month and his/her age. The answer must be correct","text_display":"\nThe pabent is assed the month and his/her age. The answer must be correct","confidence":0.22894374217200122,"confidence_rate":0.9812764915675495},{"cnt":[[562,1222],[1130,1222],[1130,1244],[562,1244]],"region":{"top_left_x":562,"top_left_y":1222,"width":568,"height":23},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8f439d57c8f14f53a69e67b80728ef8d","type":"text","conversion_output":false,"parent_id":"f086b74320bc4725bfd7e151aa3ecfb3","text":"- There is no partial creatif for being close. Aphasic and stuporous pasents","text_display":" - There is no partial creatif for being close. Aphasic and stuporous pasents","confidence":0.04090711024953595,"confidence_rate":0.9613061341867739},{"cnt":[[550,1242],[1141,1242],[1141,1265],[550,1265]],"region":{"top_left_x":549,"top_left_y":1241,"width":592,"height":24},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"022580d568ce41a2a7699e96388e7bea","type":"text","conversion_output":false,"parent_id":"f086b74320bc4725bfd7e151aa3ecfb3","text":"who do not comprenend the questons will scope 2 . Patients unable to speas.","text_display":" who do not comprenend the questons will scope 2 . Patients unable to speas.","confidence":0.18170867490827447,"confidence_rate":0.9796632465796903},{"cnt":[[558,1263],[1131,1263],[1131,1287],[558,1287]],"region":{"top_left_x":558,"top_left_y":1263,"width":573,"height":24},"line":58,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9a408195a5e343e3aab263fe78af3277","type":"text","conversion_output":false,"parent_id":"f086b74320bc4725bfd7e151aa3ecfb3","text":"because of endotracheal intubation, orotracheal trauma, severe dysartina","text_display":" because of endotracheal intubation, orotracheal trauma, severe dysartina","confidence":0.4758801866560144,"confidence_rate":0.9904023392484398},{"cnt":[[566,1282],[1126,1282],[1126,1306],[566,1306]],"region":{"top_left_x":566,"top_left_y":1282,"width":560,"height":24},"line":59,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"49dc27389891462481618f1b654a9351","type":"text","conversion_output":false,"parent_id":"f086b74320bc4725bfd7e151aa3ecfb3","text":"from any cause, language barrer or any other probiem not secondary to","text_display":" from any cause, language barrer or any other probiem not secondary to","confidence":0.5485864701400696,"confidence_rate":0.9919191732869704},{"cnt":[[558,1302],[1131,1302],[1131,1326],[558,1326]],"region":{"top_left_x":558,"top_left_y":1301,"width":573,"height":26},"line":60,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"40a88da2458b463596b90aac74658d20","type":"text","conversion_output":false,"parent_id":"f086b74320bc4725bfd7e151aa3ecfb3","text":"aphasia are given a 1. It is important that only the inital answer be graded","text_display":" aphasia are given a 1. It is important that only the inital answer be graded","confidence":0.5474097204328419,"confidence_rate":0.9925886165002841},{"cnt":[[555,1321],[1135,1321],[1135,1344],[555,1344]],"region":{"top_left_x":555,"top_left_y":1320,"width":581,"height":24},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0b46322ed8d24b23939a0f343d5e2514","type":"text","conversion_output":false,"parent_id":"f086b74320bc4725bfd7e151aa3ecfb3","text":"and that the examiner not \"helo\" the patient with verbal or non-vertal cues.","text_display":" and that the examiner not \"helo\" the patient with verbal or non-vertal cues.","confidence":0.08855095681210702,"confidence_rate":0.9705152989955845},{"cnt":[[779,1340],[909,1340],[909,1363],[779,1363]],"region":{"top_left_x":779,"top_left_y":1339,"width":130,"height":24},"line":62,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"45ab988acb924e7e97237532896767cd","type":"text","conversion_output":false,"parent_id":"f086b74320bc4725bfd7e151aa3ecfb3","text":"Coma score \"2\"","text_display":" Coma score \"2\"","confidence":0.902048729139949,"confidence_rate":0.9945890743468945},{"cnt":[[1153,1197],[1524,1197],[1524,1328],[1153,1328]],"region":{"top_left_x":1152,"top_left_y":1196,"width":372,"height":132},"line":63,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"eb3ed29a774547eab0e2cbacdd3be70d","type":"complex_cell","conversion_output":false,"parent_id":"214aacfa90e24060a843cd0a7364984d","children_ids":["d4e7c7d89a7c4e609c9dd5f2764a36f2","25483c2bd65b4c199b4d95ec53573f63","275e4aba3d9f4ee0ade2431f8b7978e1","2f7501808e5b4bec966c7bd270b38b7a","0154f9524ca646b18a4be4f13f23b8cf","42aecf5ce5204504991eecf6a3d3d1e8"],"text":"◯ \\(0=\\) Answers both questions correctly\n◯ 1=Answers one question correctly\n◯ 2=Answers neither question correctly","text_display":"◯ \\(0=\\) Answers both questions correctly\n◯ 1=Answers one question correctly\n◯ 2=Answers neither question correctly","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.7446566051803529,"confidence_rate":0.9954145930643108},{"cnt":[[1156,1201],[1191,1201],[1191,1236],[1156,1236]],"region":{"top_left_x":1155,"top_left_y":1200,"width":37,"height":37},"line":64,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d4e7c7d89a7c4e609c9dd5f2764a36f2","type":"form_field","conversion_output":false,"parent_id":"eb3ed29a774547eab0e2cbacdd3be70d","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1190,1209],[1509,1209],[1509,1237],[1190,1237]],"region":{"top_left_x":1189,"top_left_y":1208,"width":320,"height":30},"line":65,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"25483c2bd65b4c199b4d95ec53573f63","type":"text","conversion_output":false,"parent_id":"eb3ed29a774547eab0e2cbacdd3be70d","text":"\\(0=\\) Answers both questions correctly","text_display":" \\(0=\\) Answers both questions correctly","confidence":0.7988088130950928,"confidence_rate":0.9942567190187889},{"cnt":[[1156,1242],[1190,1242],[1190,1277],[1156,1277]],"region":{"top_left_x":1155,"top_left_y":1241,"width":35,"height":37},"line":66,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"275e4aba3d9f4ee0ade2431f8b7978e1","type":"form_field","conversion_output":false,"parent_id":"eb3ed29a774547eab0e2cbacdd3be70d","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1191,1252],[1495,1252],[1495,1281],[1191,1281]],"region":{"top_left_x":1191,"top_left_y":1252,"width":305,"height":30},"line":67,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2f7501808e5b4bec966c7bd270b38b7a","type":"text","conversion_output":false,"parent_id":"eb3ed29a774547eab0e2cbacdd3be70d","text":"1=Answers one question correctly","text_display":" 1=Answers one question correctly","confidence":0.7446566051803529,"confidence_rate":0.9920632286977784},{"cnt":[[1156,1285],[1190,1285],[1190,1322],[1156,1322]],"region":{"top_left_x":1155,"top_left_y":1285,"width":35,"height":38},"line":68,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0154f9524ca646b18a4be4f13f23b8cf","type":"form_field","conversion_output":false,"parent_id":"eb3ed29a774547eab0e2cbacdd3be70d","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1191,1296],[1523,1296],[1523,1325],[1191,1325]],"region":{"top_left_x":1191,"top_left_y":1296,"width":332,"height":29},"line":69,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"42aecf5ce5204504991eecf6a3d3d1e8","type":"text","conversion_output":false,"parent_id":"eb3ed29a774547eab0e2cbacdd3be70d","text":"2=Answers neither question correctly","text_display":" 2=Answers neither question correctly","confidence":0.9975600242614746,"confidence_rate":0.9999404174499809},{"cnt":[[490,1509],[517,1509],[517,1538],[490,1538]],"region":{"top_left_x":489,"top_left_y":1508,"width":29,"height":30},"line":70,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"92f74aec792445c2b00978041403fedf","type":"simple_cell","conversion_output":false,"parent_id":"214aacfa90e24060a843cd0a7364984d","text":"4","text_display":"4","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[542,1413],[1146,1413],[1146,1630],[542,1630]],"region":{"top_left_x":541,"top_left_y":1413,"width":605,"height":218},"line":71,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"69d74b81456843f5b83bf023cf549886","type":"complex_cell","conversion_output":false,"parent_id":"214aacfa90e24060a843cd0a7364984d","children_ids":["4e29f68b54ed4725bd6f5d9a20236a9a","08479c7da9644587953207f7d9d1e706","1fb0f618f59a4cfe991f7ead3bbe58c7","098a6c3ae3134c81bca7745d03ee83b2","e1d8dbba330f46f287e6b26d2a3a9b09","a87a9048dc2a45a98e264f9011641bff","4c41424b0b034bdf80341824bc229de1","e10636b9f8e840e8a56c53c46d450eb7","8a3341a45d0248579d9c780426072064"],"text":"\\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and ciose the eyes and then to gro and release the non-paretic nand. Substitute another one step command if the hands cannot De used. Credit is given if an unequivocal autempt is mace but not completed due to weakness. If the pasent does not respond to commund, the task should be demonstrated to them (partomine) and score the result (i.e. folows none, one or too commands) Patients with trauma, amputaton, or other physical impediments should be given subable cne-step communds. Ony the frost attenpt is scored. Coms score \"2\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(1c) LOC Commands \\\\\nThe patent is asked to open and ciose the eyes and then to gro and release the non-paretic nand. Substitute another one step command if the hands cannot De used. Credit is given if an unequivocal autempt is mace but not completed due to weakness. If the pasent does not respond to commund, the task should be demonstrated to them (partomine) and score the result (i.e. folows none, one or too commands) Patients with trauma, amputaton, or other physical impediments should be given subable cne-step communds. Ony the frost attenpt is scored. Coms score \"2\".\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.00906950382383206,"confidence_rate":0.9719176046625521},{"cnt":[[744,1419],[944,1419],[944,1448],[744,1448]],"region":{"top_left_x":743,"top_left_y":1418,"width":202,"height":30},"line":72,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4e29f68b54ed4725bd6f5d9a20236a9a","type":"text","conversion_output":false,"parent_id":"69d74b81456843f5b83bf023cf549886","text":"(1c) LOC Commands","text_display":"(1c) LOC Commands","confidence":0.9350900650024414,"confidence_rate":0.9969540833305071},{"cnt":[[547,1463],[1142,1463],[1142,1488],[547,1488]],"region":{"top_left_x":547,"top_left_y":1462,"width":595,"height":27},"line":73,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"08479c7da9644587953207f7d9d1e706","type":"text","conversion_output":false,"parent_id":"69d74b81456843f5b83bf023cf549886","text":"The patent is asked to open and ciose the eyes and then to gro and release","text_display":"\nThe patent is asked to open and ciose the eyes and then to gro and release","confidence":0.25755431858353256,"confidence_rate":0.9829753868939223},{"cnt":[[563,1484],[1127,1484],[1127,1508],[563,1508]],"region":{"top_left_x":563,"top_left_y":1484,"width":564,"height":24},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1fb0f618f59a4cfe991f7ead3bbe58c7","type":"text","conversion_output":false,"parent_id":"69d74b81456843f5b83bf023cf549886","text":"the non-paretic nand. Substitute another one step command if the hands","text_display":" the non-paretic nand. Substitute another one step command if the hands","confidence":0.282245851778678,"confidence_rate":0.9832750837121925},{"cnt":[[563,1503],[1130,1503],[1130,1527],[563,1527]],"region":{"top_left_x":563,"top_left_y":1503,"width":567,"height":24},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"098a6c3ae3134c81bca7745d03ee83b2","type":"text","conversion_output":false,"parent_id":"69d74b81456843f5b83bf023cf549886","text":"cannot De used. Credit is given if an unequivocal autempt is mace but not","text_display":" cannot De used. Credit is given if an unequivocal autempt is mace but not","confidence":0.08291636812676556,"confidence_rate":0.9685820441964932},{"cnt":[[546,1524],[1143,1524],[1143,1549],[546,1549]],"region":{"top_left_x":545,"top_left_y":1523,"width":599,"height":26},"line":76,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e1d8dbba330f46f287e6b26d2a3a9b09","type":"text","conversion_output":false,"parent_id":"69d74b81456843f5b83bf023cf549886","text":"completed due to weakness. If the pasent does not respond to commund, the","text_display":" completed due to weakness. If the pasent does not respond to commund, the","confidence":0.7679627000788886,"confidence_rate":0.9966209256241436},{"cnt":[[548,1544],[1139,1544],[1139,1569],[548,1569]],"region":{"top_left_x":548,"top_left_y":1544,"width":592,"height":25},"line":77,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a87a9048dc2a45a98e264f9011641bff","type":"text","conversion_output":false,"parent_id":"69d74b81456843f5b83bf023cf549886","text":"task should be demonstrated to them (partomine) and score the result (i.e.","text_display":" task should be demonstrated to them (partomine) and score the result (i.e.","confidence":0.11218516946190223,"confidence_rate":0.9726886907083973},{"cnt":[[557,1565],[1135,1565],[1135,1587],[557,1587]],"region":{"top_left_x":556,"top_left_y":1564,"width":580,"height":23},"line":78,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4c41424b0b034bdf80341824bc229de1","type":"text","conversion_output":false,"parent_id":"69d74b81456843f5b83bf023cf549886","text":"folows none, one or too commands) Patients with trauma, amputaton, or","text_display":" folows none, one or too commands) Patients with trauma, amputaton, or","confidence":0.00906950382383206,"confidence_rate":0.938425450260615},{"cnt":[[558,1585],[1130,1585],[1130,1609],[558,1609]],"region":{"top_left_x":558,"top_left_y":1585,"width":572,"height":24},"line":79,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e10636b9f8e840e8a56c53c46d450eb7","type":"text","conversion_output":false,"parent_id":"69d74b81456843f5b83bf023cf549886","text":"other physical impediments should be given subable cne-step communds.","text_display":" other physical impediments should be given subable cne-step communds.","confidence":0.021971901226803675,"confidence_rate":0.949713925236645},{"cnt":[[654,1604],[1037,1604],[1037,1628],[654,1628]],"region":{"top_left_x":653,"top_left_y":1604,"width":384,"height":24},"line":80,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8a3341a45d0248579d9c780426072064","type":"text","conversion_output":false,"parent_id":"69d74b81456843f5b83bf023cf549886","text":"Ony the frost attenpt is scored. Coms score \"2\".","text_display":" Ony the frost attenpt is scored. Coms score \"2\".","confidence":0.11307978441594839,"confidence_rate":0.9597084951095352},{"cnt":[[1153,1460],[1490,1460],[1490,1591],[1153,1591]],"region":{"top_left_x":1152,"top_left_y":1459,"width":338,"height":132},"line":81,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7ac56fb90dcf46fcb2ebc5167e0e58e5","type":"complex_cell","conversion_output":false,"parent_id":"214aacfa90e24060a843cd0a7364984d","children_ids":["3dd908077fc34b2facdba7839ee23cf2","c1b01f1d0cc34872bd1fa31c1fda97cb","7fd4c775f0604ca2a4c01b06186d6de8","a930695844b64523a453936cb14d07b7","55dc7bad175b4ee7979fa964ac3a6561","6a0248d8afc2412cb3098aec4f5612a2"],"text":"◯ 0=Performs both tasks correctly\n◯ 1=Performs one task correctly\n◯ 2=Performs neither task correctly","text_display":"◯ 0=Performs both tasks correctly\n◯ 1=Performs one task correctly\n◯ 2=Performs neither task correctly","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.35185657907277346,"confidence_rate":0.98687659889986},{"cnt":[[1156,1463],[1191,1463],[1191,1498],[1156,1498]],"region":{"top_left_x":1155,"top_left_y":1462,"width":37,"height":37},"line":82,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3dd908077fc34b2facdba7839ee23cf2","type":"form_field","conversion_output":false,"parent_id":"7ac56fb90dcf46fcb2ebc5167e0e58e5","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1191,1501],[1191,1470],[1476,1471],[1476,1502]],"region":{"top_left_x":1190,"top_left_y":1469,"width":287,"height":34},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c1b01f1d0cc34872bd1fa31c1fda97cb","type":"text","conversion_output":false,"parent_id":"7ac56fb90dcf46fcb2ebc5167e0e58e5","text":"0=Performs both tasks correctly","text_display":" 0=Performs both tasks correctly","confidence":0.8094197611687931,"confidence_rate":0.9941439463563242},{"cnt":[[1156,1506],[1190,1506],[1190,1540],[1156,1540]],"region":{"top_left_x":1155,"top_left_y":1506,"width":35,"height":35},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7fd4c775f0604ca2a4c01b06186d6de8","type":"form_field","conversion_output":false,"parent_id":"7ac56fb90dcf46fcb2ebc5167e0e58e5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1191,1516],[1460,1516],[1460,1544],[1191,1544]],"region":{"top_left_x":1191,"top_left_y":1515,"width":269,"height":30},"line":85,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a930695844b64523a453936cb14d07b7","type":"text","conversion_output":false,"parent_id":"7ac56fb90dcf46fcb2ebc5167e0e58e5","text":"1=Performs one task correctly","text_display":" 1=Performs one task correctly","confidence":0.35185657907277346,"confidence_rate":0.9697455915915913},{"cnt":[[1156,1550],[1190,1550],[1190,1584],[1156,1584]],"region":{"top_left_x":1155,"top_left_y":1549,"width":35,"height":35},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"55dc7bad175b4ee7979fa964ac3a6561","type":"form_field","conversion_output":false,"parent_id":"7ac56fb90dcf46fcb2ebc5167e0e58e5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1190,1559],[1487,1559],[1487,1587],[1190,1587]],"region":{"top_left_x":1189,"top_left_y":1559,"width":299,"height":28},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6a0248d8afc2412cb3098aec4f5612a2","type":"text","conversion_output":false,"parent_id":"7ac56fb90dcf46fcb2ebc5167e0e58e5","text":"2=Performs neither task correctly","text_display":" 2=Performs neither task correctly","confidence":0.8910369873046875,"confidence_rate":0.9969685688248592},{"cnt":[[490,1795],[517,1795],[517,1823],[490,1823]],"region":{"top_left_x":489,"top_left_y":1795,"width":29,"height":28},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"89d4c1bc0a0b4882a39b902eb2ff4da1","type":"simple_cell","conversion_output":false,"parent_id":"214aacfa90e24060a843cd0a7364984d","text":"5","text_display":"5","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[544,1681],[1146,1681],[1146,1940],[544,1940]],"region":{"top_left_x":544,"top_left_y":1680,"width":602,"height":261},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f94c792c7c4f4a9fb7c66f724b56c53c","type":"complex_cell","conversion_output":false,"parent_id":"214aacfa90e24060a843cd0a7364984d","children_ids":["9c8cef9968904990a0a97cc0044220fc","e43a31df033b4f8f988dca662820dec3","1650c4e51268419b8759163053700c3a","8bb7bbd8d277405e8fe5b561d5b14304","c323c48577e344609d405caf70f0a682","7c1c8d1c9329484184609565d48c30a7","03c15703d757436aa71da2018df3c471","930539b89919449aae63dfd56c58d49b","a870b3f0198b43babcf4492e5b25280d","c500ecc373ae4c14971f664a62278b0c","3e5395c5490946b98079ba398dc4a3b5"],"text":"\\begin{tabular}{l}\n(2) Best Gaze \\\\\nOny horizontal eye movements will be tested. Voluntary or reflexte (Douldocephalle) eye movements will be scored but calonc testing is not done. If the patient has a confugate deviaton of the eyes trut can be overcome by voluntarly of reflexter activity, the score will be 1. F a patent has an solated pertpheral neve paresis (CN III, IV or VI) score a 1. Gaze is testable in all aphasio patents. Pacents alth ocular trauma, bandages, pre-evisting \\\\\n![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-288.jpg?height=22\\&width=564\\&top_left_y=1852\\&top_left_x=563) refexive movements and a choice made by the investigator. Estabiling eye contact and then moving aoout the pattent from sole to side will occasionaly darity the presence of a partal gaze paisy. Coma score as examined.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(2) Best Gaze \\\\\nOny horizontal eye movements will be tested. Voluntary or reflexte (Douldocephalle) eye movements will be scored but calonc testing is not done. If the patient has a confugate deviaton of the eyes trut can be overcome by voluntarly of reflexter activity, the score will be 1. F a patent has an solated pertpheral neve paresis (CN III, IV or VI) score a 1. Gaze is testable in all aphasio patents. Pacents alth ocular trauma, bandages, pre-evisting \\\\\n![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-288.jpg?height=22\\&width=564\\&top_left_y=1852\\&top_left_x=563) refexive movements and a choice made by the investigator. Estabiling eye contact and then moving aoout the pattent from sole to side will occasionaly darity the presence of a partal gaze paisy. Coma score as examined.\n\\end{tabular}","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.02114610755325277,"confidence_rate":0.9771491416095393},{"cnt":[[774,1686],[917,1686],[917,1712],[774,1712]],"region":{"top_left_x":773,"top_left_y":1686,"width":144,"height":27},"line":90,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9c8cef9968904990a0a97cc0044220fc","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"(2) Best Gaze","text_display":"(2) Best Gaze","confidence":0.9990234375,"confidence_rate":0.9999457214926967},{"cnt":[[581,1730],[1108,1730],[1108,1756],[581,1756]],"region":{"top_left_x":581,"top_left_y":1729,"width":527,"height":27},"line":91,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e43a31df033b4f8f988dca662820dec3","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"Ony horizontal eye movements will be tested. Voluntary or reflexte","text_display":"\nOny horizontal eye movements will be tested. Voluntary or reflexte","confidence":0.421169628150444,"confidence_rate":0.9878947162368821},{"cnt":[[547,1752],[1141,1752],[1141,1775],[547,1775]],"region":{"top_left_x":547,"top_left_y":1751,"width":594,"height":24},"line":92,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1650c4e51268419b8759163053700c3a","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"(Douldocephalle) eye movements will be scored but calonc testing is not done.","text_display":" (Douldocephalle) eye movements will be scored but calonc testing is not done.","confidence":0.10666206036893387,"confidence_rate":0.9730753318694515},{"cnt":[[550,1772],[1138,1772],[1138,1795],[550,1795]],"region":{"top_left_x":549,"top_left_y":1772,"width":589,"height":24},"line":93,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8bb7bbd8d277405e8fe5b561d5b14304","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"If the patient has a confugate deviaton of the eyes trut can be overcome by","text_display":" If the patient has a confugate deviaton of the eyes trut can be overcome by","confidence":0.17419546870510033,"confidence_rate":0.9783921525517594},{"cnt":[[553,1790],[1138,1790],[1138,1816],[553,1816]],"region":{"top_left_x":552,"top_left_y":1789,"width":586,"height":27},"line":94,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c323c48577e344609d405caf70f0a682","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"voluntarly of reflexter activity, the score will be 1. F a patent has an solated","text_display":" voluntarly of reflexter activity, the score will be 1. F a patent has an solated","confidence":0.02114610755325277,"confidence_rate":0.9556455210297976},{"cnt":[[558,1812],[1130,1812],[1130,1838],[558,1838]],"region":{"top_left_x":558,"top_left_y":1811,"width":572,"height":27},"line":95,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7c1c8d1c9329484184609565d48c30a7","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"pertpheral neve paresis (CN III, IV or VI) score a 1. Gaze is testable in all","text_display":" pertpheral neve paresis (CN III, IV or VI) score a 1. Gaze is testable in all","confidence":0.35080421795345407,"confidence_rate":0.9873065309287973},{"cnt":[[577,1832],[1113,1832],[1113,1857],[577,1857]],"region":{"top_left_x":577,"top_left_y":1832,"width":537,"height":25},"line":96,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"03c15703d757436aa71da2018df3c471","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"aphasio patents. Pacents alth ocular trauma, bandages, pre-evisting","text_display":" aphasio patents. Pacents alth ocular trauma, bandages, pre-evisting","confidence":0.026643152977442314,"confidence_rate":0.9508962475729678},{"cnt":[[563,1853],[1127,1853],[1127,1873],[563,1873]],"region":{"top_left_x":563,"top_left_y":1852,"width":564,"height":22},"line":97,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"930539b89919449aae63dfd56c58d49b","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-288.jpg?height=22\\&width=564\\&top_left_y=1852\\&top_left_x=563)"},{"cnt":[[547,1870],[1143,1870],[1143,1895],[547,1895]],"region":{"top_left_x":547,"top_left_y":1870,"width":597,"height":26},"line":98,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a870b3f0198b43babcf4492e5b25280d","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"refexive movements and a choice made by the investigator. Estabiling eye","text_display":" refexive movements and a choice made by the investigator. Estabiling eye","confidence":0.047151879429982516,"confidence_rate":0.9611091555912147},{"cnt":[[550,1891],[1139,1891],[1139,1917],[550,1917]],"region":{"top_left_x":549,"top_left_y":1890,"width":591,"height":27},"line":99,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c500ecc373ae4c14971f664a62278b0c","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"contact and then moving aoout the pattent from sole to side will occasionaly","text_display":" contact and then moving aoout the pattent from sole to side will occasionaly","confidence":0.2516495218365187,"confidence_rate":0.9831106959127996},{"cnt":[[569,1913],[1119,1913],[1119,1936],[569,1936]],"region":{"top_left_x":568,"top_left_y":1912,"width":551,"height":24},"line":100,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3e5395c5490946b98079ba398dc4a3b5","type":"text","conversion_output":false,"parent_id":"f94c792c7c4f4a9fb7c66f724b56c53c","text":"darity the presence of a partal gaze paisy. Coma score as examined.","text_display":" darity the presence of a partal gaze paisy. Coma score as examined.","confidence":0.7183809754955611,"confidence_rate":0.995416712630314},{"cnt":[[1152,1714],[1772,1712],[1773,1915],[1153,1917]],"region":{"top_left_x":1152,"top_left_y":1712,"width":621,"height":205},"line":101,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cf655c0cd663403cb89b2f2508f3b657","type":"complex_cell","conversion_output":false,"parent_id":"214aacfa90e24060a843cd0a7364984d","children_ids":["921ad36d18124554b47242d565b0c12b","f884fb7ca874416791291c0cd748cbe8","2c2a88f1f0014bff8e585131f4149752","bd114fc103034431bcb0220f0f2c3d3c","aa39c76d40dc469faba3c711718738a6","9b05f1e0e9814af29c00c07875232d6f","92642b56ac1b4cf3b988ae0880b6e96c","4b450110e8d44df1b813473cf56688b8","1a948253c7f54644884e6d7933bbd5f3"],"text":"◯ 0=Normal\n◯ \\(1=\\) Partial gaze palsy. This score is given when gaze is abnormal in one or both eyes, but where forced deviation or total gaze paresis are not present\n◯ \\(2=\\) Forced deviation, or total gaze paresis not overcome by the oculocephalic maneuver","text_display":"◯ 0=Normal\n◯ \\(1=\\) Partial gaze palsy. This score is given when gaze is abnormal in one or both eyes, but where forced deviation or total gaze paresis are not present\n◯ \\(2=\\) Forced deviation, or total gaze paresis not overcome by the oculocephalic maneuver","cell_row":5,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.43359282320415754,"confidence_rate":0.9940974273250633},{"cnt":[[1156,1716],[1190,1716],[1190,1750],[1156,1750]],"region":{"top_left_x":1155,"top_left_y":1716,"width":35,"height":35},"line":102,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"921ad36d18124554b47242d565b0c12b","type":"form_field","conversion_output":false,"parent_id":"cf655c0cd663403cb89b2f2508f3b657","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1191,1727],[1282,1727],[1282,1750],[1191,1750]],"region":{"top_left_x":1191,"top_left_y":1727,"width":92,"height":24},"line":103,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f884fb7ca874416791291c0cd748cbe8","type":"text","conversion_output":false,"parent_id":"cf655c0cd663403cb89b2f2508f3b657","text":"0=Normal","text_display":" 0=Normal","confidence":0.8298335355950662,"confidence_rate":0.9857539750893961},{"cnt":[[1156,1757],[1190,1757],[1190,1791],[1156,1791]],"region":{"top_left_x":1155,"top_left_y":1757,"width":35,"height":35},"line":104,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2c2a88f1f0014bff8e585131f4149752","type":"form_field","conversion_output":false,"parent_id":"cf655c0cd663403cb89b2f2508f3b657","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1191,1768],[1768,1768],[1768,1797],[1191,1797]],"region":{"top_left_x":1191,"top_left_y":1768,"width":578,"height":29},"line":105,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bd114fc103034431bcb0220f0f2c3d3c","type":"text","conversion_output":false,"parent_id":"cf655c0cd663403cb89b2f2508f3b657","text":"\\(1=\\) Partial gaze palsy. This score is given when gaze is abnormal","text_display":" \\(1=\\) Partial gaze palsy. This score is given when gaze is abnormal","confidence":0.43359282320415754,"confidence_rate":0.9877862394447658},{"cnt":[[1218,1794],[1754,1794],[1754,1821],[1218,1821]],"region":{"top_left_x":1218,"top_left_y":1794,"width":537,"height":28},"line":106,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"aa39c76d40dc469faba3c711718738a6","type":"text","conversion_output":false,"parent_id":"cf655c0cd663403cb89b2f2508f3b657","text":"in one or both eyes, but where forced deviation or total gaze","text_display":" in one or both eyes, but where forced deviation or total gaze","confidence":0.9941489668563008,"confidence_rate":0.9999110915661991},{"cnt":[[1218,1820],[1430,1820],[1430,1846],[1218,1846]],"region":{"top_left_x":1218,"top_left_y":1819,"width":212,"height":27},"line":107,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9b05f1e0e9814af29c00c07875232d6f","type":"text","conversion_output":false,"parent_id":"cf655c0cd663403cb89b2f2508f3b657","text":"paresis are not present","text_display":" paresis are not present","confidence":0.9716796875,"confidence_rate":0.9989744880385678},{"cnt":[[1156,1845],[1190,1845],[1190,1881],[1156,1881]],"region":{"top_left_x":1155,"top_left_y":1844,"width":35,"height":38},"line":108,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"92642b56ac1b4cf3b988ae0880b6e96c","type":"form_field","conversion_output":false,"parent_id":"cf655c0cd663403cb89b2f2508f3b657","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1190,1855],[1738,1855],[1738,1884],[1190,1884]],"region":{"top_left_x":1189,"top_left_y":1855,"width":550,"height":30},"line":109,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4b450110e8d44df1b813473cf56688b8","type":"text","conversion_output":false,"parent_id":"cf655c0cd663403cb89b2f2508f3b657","text":"\\(2=\\) Forced deviation, or total gaze paresis not overcome by the","text_display":" \\(2=\\) Forced deviation, or total gaze paresis not overcome by the","confidence":0.6576980646032852,"confidence_rate":0.9936714838660994},{"cnt":[[1210,1883],[1432,1883],[1432,1911],[1210,1911]],"region":{"top_left_x":1210,"top_left_y":1882,"width":223,"height":30},"line":110,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1a948253c7f54644884e6d7933bbd5f3","type":"text","conversion_output":false,"parent_id":"cf655c0cd663403cb89b2f2508f3b657","text":"oculocephalic maneuver","text_display":" oculocephalic maneuver","confidence":0.96240234375,"confidence_rate":0.9985816483311218},{"cnt":[[460,2378],[853,2378],[853,2413],[460,2413]],"region":{"top_left_x":459,"top_left_y":2378,"width":394,"height":35},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"097e4679988d48f7bb72e545b5bde63e","type":"text","conversion_output":true,"text":"Alteplase-Genentech, Inc.","text_display":"\n\nAlteplase-Genentech, Inc.","confidence":0.9941489696502686,"confidence_rate":0.9998044119734548},{"cnt":[[460,2415],[896,2415],[896,2447],[460,2447]],"region":{"top_left_x":459,"top_left_y":2414,"width":437,"height":34},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb4d8b0702c84c9f8d1f32b14a04172f","type":"text","conversion_output":true,"text":"79/Protocol ML29093, Version 3","text_display":"\n79/Protocol ML29093, Version 3","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2df6dfa048c141678d7874ea66a78bd2","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9907509953584395,"confidence_rate":0.9998570557211897},{"cnt":[[372,2608],[694,2608],[694,2645],[372,2645]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":37},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16485aa65e6a4e7d99795c53a44f7c3f","type":"page_info","conversion_output":false,"text":"624/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-289","page":289,"lines":[{"cnt":[[610,374],[1622,374],[1622,479],[610,479]],"region":{"top_left_x":610,"top_left_y":373,"width":1013,"height":107},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04d29993a0ce49728de16c40f12059b6","type":"section_header","conversion_output":false,"children_ids":["240bcecf85754a31b3c3405bd29b06dc","26c9af79bd194e8da111f44478a840cb"],"text":"","text_display":""},{"cnt":[[928,382],[1304,382],[1304,428],[928,428]],"region":{"top_left_x":928,"top_left_y":382,"width":377,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"240bcecf85754a31b3c3405bd29b06dc","type":"text","conversion_output":true,"parent_id":"04d29993a0ce49728de16c40f12059b6","text":"Appendix 7 (cont.)","text_display":"\n\n\\section*{Appendix 7 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[614,425],[1618,425],[1618,473],[614,473]],"region":{"top_left_x":614,"top_left_y":425,"width":1004,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26c9af79bd194e8da111f44478a840cb","type":"text","conversion_output":true,"parent_id":"04d29993a0ce49728de16c40f12059b6","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":" National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.9931755065917969,"confidence_rate":0.999875500718753},{"cnt":[[460,522],[1807,522],[1807,2011],[460,2011]],"region":{"top_left_x":459,"top_left_y":522,"width":1348,"height":1489},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e0ff46a7aeff4c41bf70c75e511ad57e","type":"table","conversion_output":true,"children_ids":["b56a5f53442c44eeb2085eda4c0dbdf7","0b546dd312864835a7e3ee118580d91d","758e7340f7b740c9a35e3f13ee70388e","705b8fc938974ecf83d7f2883685d19b","4a2f048d581047b6a5a283b70791c023","57274133a6f9444fb038a1672ba519bd","34ecf488773044dfbc7397e550a406c3","05dff9381ae441a89aa1728c01875a1d","99f6edf9365a432ebfcc118f4d8fd8d2","cbd281d296c44ea1a63b910f25d317f6","90213f450ed24520807deb1ad0898a9a","6a76f1b1bacd4ce1a81c9f9d3008ccea","3a244c46716d4478ad2b019c260d4a7a","e2701cda79764bafbef1c845884eec06","1881f0c8b71848028cc6feb4bcfbc6e5","1f6af21fb6cd4585b85e19ded04d5868","8a6001467db64034886e77a6b7f986bd","e063b4cb7afd4f6c882794d0653f1368","70aa6a58ea89464391f5a16ad502facf","a62ef83964c14a239e85ec6badd6678b","15515d932cf542b6a5d38a149781f725","67dd4c840e484e59a8a828e8584c8342","550c78c8a835468585d0784830d80a65","a3e87d4acf1246e8a9e8f3fc0eb5e3e9","51be7fc8e7f84b39960814c26291240a"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline 8 & \\begin{tabular}{l}\n(3) Visual \\\\\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, but if they look at the side of the moving fingers appropriately, this can be scored as normal. If there is unliateral bilndness or enucleaton, visual frelds in the remaining eye are scored. Score 1 only if a clear-cut asymmetry, including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous sitmulaton is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22. Score as examined, using bilateral threat.\n\\end{tabular} & ◯ 0=No visual loss\n◯ \\(1=\\) Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral hemianopia (blind including cortical blindness) \\\\\n\\hline 7 & \\begin{tabular}{l}\n(4) Facial Palsy \\\\\nAsk, or use pantomime to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responsive or non-comprehending patent. If facial traumalbandages, orotracheal tude, tape or other physical barrier obscures the face, these should be removed to the extent possible. Coma Score \"3\".\n\\end{tabular} & ◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face) \\\\\n\\hline 8 & \\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the voice and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma Score \" 4 \"\n\\end{tabular} & ◯ \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ 1=Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f culed) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 9 & Explain if amputation or joint fusion (Motor Arm Left): & \\\\\n\\hline 10 & \\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the anms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the am tals before 10 seconds of the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomine but not noxious stimusation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 11 & Explain if amputation or joint fusion (Motor Arm Right): & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 8 & \\begin{tabular}{l}\n(3) Visual \\\\\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, but if they look at the side of the moving fingers appropriately, this can be scored as normal. If there is unliateral bilndness or enucleaton, visual frelds in the remaining eye are scored. Score 1 only if a clear-cut asymmetry, including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous sitmulaton is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22. Score as examined, using bilateral threat.\n\\end{tabular} & ◯ 0=No visual loss\n◯ \\(1=\\) Partial hemianopia\n◯ 2=Complete hemianopia\n◯ 3=Bilateral hemianopia (blind including cortical blindness) \\\\\n\\hline 7 & \\begin{tabular}{l}\n(4) Facial Palsy \\\\\nAsk, or use pantomime to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responsive or non-comprehending patent. If facial traumalbandages, orotracheal tude, tape or other physical barrier obscures the face, these should be removed to the extent possible. Coma Score \"3\".\n\\end{tabular} & ◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face) \\\\\n\\hline 8 & \\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the voice and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma Score \" 4 \"\n\\end{tabular} & ◯ \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ 1=Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f culed) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 9 & Explain if amputation or joint fusion (Motor Arm Left): & \\\\\n\\hline 10 & \\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the anms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the am tals before 10 seconds of the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomine but not noxious stimusation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 11 & Explain if amputation or joint fusion (Motor Arm Right): & 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Visual \\\\\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, but if they look at the side of the moving fingers appropriately, this can be scored as normal. If there is unliateral bilndness or enucleaton, visual frelds in the remaining eye are scored. Score 1 only if a clear-cut asymmetry, including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous sitmulaton is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22. Score as examined, using bilateral threat.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(3) Visual \\\\\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger counting or wsual threat as appropriate. Patient must be encouraged, but if they look at the side of the moving fingers appropriately, this can be scored as normal. If there is unliateral bilndness or enucleaton, visual frelds in the remaining eye are scored. Score 1 only if a clear-cut asymmetry, including quadrantanopla is found. If patent is bilnd from any cause score 3. Double simultaneous sitmulaton is performed at this point. If there is extinction patient recelves a 1 and the results are used to answer question 22. Score as examined, using bilateral threat.\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.08557720359079639,"confidence_rate":0.9900960376718745},{"cnt":[[814,547],[919,547],[919,572],[814,572]],"region":{"top_left_x":813,"top_left_y":546,"width":106,"height":27},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"679aed5156834825a544d3b2efe4d0fe","type":"text","conversion_output":false,"parent_id":"90213f450ed24520807deb1ad0898a9a","text":"(3) Visual","text_display":"(3) Visual","confidence":1,"confidence_rate":1},{"cnt":[[541,593],[1178,593],[1178,616],[541,616]],"region":{"top_left_x":540,"top_left_y":592,"width":638,"height":25},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9aebfd6a4f4d4b63bf4f858fdc4979c9","type":"text","conversion_output":false,"parent_id":"90213f450ed24520807deb1ad0898a9a","text":"Visual fields (upper and lower quadrants) are tested by confrontation, using finger","text_display":"\nVisual fields (upper and lower quadrants) are tested by confrontation, using finger","confidence":0.7082925041634581,"confidence_rate":0.9960883734980469},{"cnt":[[541,613],[1164,613],[1164,635],[541,635]],"region":{"top_left_x":540,"top_left_y":613,"width":625,"height":23},"line":18,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f88cfa8a14e542959556444b897f3601","type":"text","conversion_output":false,"parent_id":"90213f450ed24520807deb1ad0898a9a","text":"counting or wsual threat as appropriate. Patient must be encouraged, but if they","text_display":" counting or wsual threat as appropriate. Patient must be encouraged, but if they","confidence":0.08557720359079639,"confidence_rate":0.9714926225656011},{"cnt":[[541,632],[1192,632],[1192,654],[541,654]],"region":{"top_left_x":540,"top_left_y":632,"width":652,"height":23},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3967d8182eb04e9f82627da86f15cc54","type":"text","conversion_output":false,"parent_id":"90213f450ed24520807deb1ad0898a9a","text":"look at the side of the moving fingers appropriately, this can be scored as normal. If","text_display":" look at the side of the moving fingers appropriately, this can be scored as normal. If","confidence":0.7413873190884601,"confidence_rate":0.996717135669713},{"cnt":[[541,653],[1167,653],[1167,676],[541,676]],"region":{"top_left_x":540,"top_left_y":652,"width":628,"height":25},"line":20,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"576d9dc1505e46b28bc70456728ab35a","type":"text","conversion_output":false,"parent_id":"90213f450ed24520807deb1ad0898a9a","text":"there is unliateral bilndness or enucleaton, visual frelds in the remaining eye are","text_display":" there is unliateral bilndness or enucleaton, visual frelds in the remaining eye are","confidence":0.2287914078437818,"confidence_rate":0.9833789458444488},{"cnt":[[541,675],[1192,675],[1192,695],[541,695]],"region":{"top_left_x":540,"top_left_y":674,"width":652,"height":22},"line":21,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"43c11f9d4c4e4226ae5e60f4e330f740","type":"text","conversion_output":false,"parent_id":"90213f450ed24520807deb1ad0898a9a","text":"scored. Score 1 only if a clear-cut asymmetry, including quadrantanopla is found. If","text_display":" scored. Score 1 only if a clear-cut asymmetry, including quadrantanopla is found. If","confidence":0.7337378497879998,"confidence_rate":0.996640401047805},{"cnt":[[541,694],[1126,694],[1126,714],[541,714]],"region":{"top_left_x":540,"top_left_y":693,"width":587,"height":22},"line":22,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2ef04bf536cb4114839c6c135a50c9df","type":"text","conversion_output":false,"parent_id":"90213f450ed24520807deb1ad0898a9a","text":"patent is bilnd from any cause score 3. Double simultaneous sitmulaton is","text_display":" patent is bilnd from any cause score 3. 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If there is extinction patient recelves a 1 and the results are","confidence":0.8870279915798596,"confidence_rate":0.9987520424767933},{"cnt":[[541,733],[1102,733],[1102,755],[541,755]],"region":{"top_left_x":540,"top_left_y":733,"width":562,"height":23},"line":24,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6d6cde29e8cd4badb752b39c474f5c67","type":"text","conversion_output":false,"parent_id":"90213f450ed24520807deb1ad0898a9a","text":"used to answer question 22. Score as examined, using bilateral threat.","text_display":" used to answer question 22. 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Facial Palsy \\\\\nAsk, or use pantomime to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responsive or non-comprehending patent. If facial traumalbandages, orotracheal tude, tape or other physical barrier obscures the face, these should be removed to the extent possible. Coma Score \"3\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(4) Facial Palsy \\\\\nAsk, or use pantomime to encourage the patient to show teeth or raise eyebrows and close eyes. Score symmetry of grimace in response to noxlous stimull in the poorly responsive or non-comprehending patent. If facial traumalbandages, orotracheal tude, tape or other physical barrier obscures the face, these should be removed to the extent possible. Coma Score \"3\".\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.3067993171582661,"confidence_rate":0.9917073367967901},{"cnt":[[792,871],[941,871],[941,900],[792,900]],"region":{"top_left_x":791,"top_left_y":871,"width":150,"height":29},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"eb4062a1782b4f21a97cea68befbf09a","type":"text","conversion_output":false,"parent_id":"e2701cda79764bafbef1c845884eec06","text":"(4) Facial Palsy","text_display":"(4) Facial Palsy","confidence":1,"confidence_rate":1},{"cnt":[[539,918],[1172,918],[1172,941],[539,941]],"region":{"top_left_x":539,"top_left_y":917,"width":634,"height":24},"line":37,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3523d05885d041698597d5c152b6b76f","type":"text","conversion_output":false,"parent_id":"e2701cda79764bafbef1c845884eec06","text":"Ask, or use pantomime to encourage the patient to show teeth or raise eyebrows","text_display":"\nAsk, or use pantomime to encourage the patient to show teeth or raise eyebrows","confidence":0.6807594816071411,"confidence_rate":0.9953776292113244},{"cnt":[[541,939],[1170,939],[1170,961],[541,961]],"region":{"top_left_x":540,"top_left_y":939,"width":630,"height":23},"line":38,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0f92109f1b4745e1b992da1ff8674d94","type":"text","conversion_output":false,"parent_id":"e2701cda79764bafbef1c845884eec06","text":"and close eyes. Score symmetry of grimace in response to noxlous stimull in the","text_display":" and close eyes. Score symmetry of grimace in response to noxlous stimull in the","confidence":0.7792798417935289,"confidence_rate":0.997035532908094},{"cnt":[[541,959],[1133,959],[1133,982],[541,982]],"region":{"top_left_x":540,"top_left_y":958,"width":593,"height":24},"line":39,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c18e5941481a4b8d8e170629ae9b1a34","type":"text","conversion_output":false,"parent_id":"e2701cda79764bafbef1c845884eec06","text":"poorly responsive or non-comprehending patent. If facial traumalbandages,","text_display":" poorly responsive or non-comprehending patent. If facial traumalbandages,","confidence":0.3067993171582661,"confidence_rate":0.984965933656955},{"cnt":[[541,980],[1183,980],[1183,1004],[541,1004]],"region":{"top_left_x":540,"top_left_y":980,"width":644,"height":24},"line":40,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9e9883d4239640ea99faca406ea6838c","type":"text","conversion_output":false,"parent_id":"e2701cda79764bafbef1c845884eec06","text":"orotracheal tude, tape or other physical barrier obscures the face, these should be","text_display":" orotracheal tude, tape or other physical barrier obscures the face, these should be","confidence":0.35650934353496017,"confidence_rate":0.9883480204893679},{"cnt":[[541,999],[927,999],[927,1023],[541,1023]],"region":{"top_left_x":540,"top_left_y":999,"width":387,"height":24},"line":41,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2cb0638572a14ee48532990f0dceff2e","type":"text","conversion_output":false,"parent_id":"e2701cda79764bafbef1c845884eec06","text":"removed to the extent possible. Coma Score \"3\".","text_display":" removed to the extent possible. Coma Score \"3\".","confidence":0.446807025000453,"confidence_rate":0.9846265413342906},{"cnt":[[1201,829],[1785,829],[1785,1047],[1201,1047]],"region":{"top_left_x":1201,"top_left_y":828,"width":584,"height":220},"line":42,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1881f0c8b71848028cc6feb4bcfbc6e5","type":"complex_cell","conversion_output":false,"parent_id":"e0ff46a7aeff4c41bf70c75e511ad57e","children_ids":["3ef5576b2a744944a6fc20dbaa521555","1d2423206e8243c590897143d5a5f711","8262443b5aaf4ca3900327177bbbfdd5","6d8bfe0ccee44ee6806ee7773f1a4dcb","72823ff7491442fc8025af8bcbb7cbd3","582e27eeb962485fb98cdcb265506355","75d98b1d74b04e5aaac95e5dadebd045","945b0aeeb7c14ac1b2a980c7d653a244","f5658645d52e4166822eb7133821a7bb","0cf955a1f54d4e84aaf3c55ee2883867"],"text":"◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower face)","text_display":"◯ 0=Normal symmetrical movement\n◯ \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of smiling)\n◯ 2=Partial paralysis (total or near total paralysis of lower face)\n◯ 3=Complete paralysis of one or both sides (absence of facial movement in the upper and lower 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movement","confidence":0.9063449028307924,"confidence_rate":0.9971119620188668},{"cnt":[[1204,874],[1238,874],[1238,908],[1204,908]],"region":{"top_left_x":1203,"top_left_y":873,"width":35,"height":36},"line":45,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8262443b5aaf4ca3900327177bbbfdd5","type":"form_field","conversion_output":false,"parent_id":"1881f0c8b71848028cc6feb4bcfbc6e5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1239,885],[1759,885],[1759,912],[1239,912]],"region":{"top_left_x":1239,"top_left_y":884,"width":521,"height":29},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6d8bfe0ccee44ee6806ee7773f1a4dcb","type":"text","conversion_output":false,"parent_id":"1881f0c8b71848028cc6feb4bcfbc6e5","text":"\\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of","text_display":" \\(1=\\) Minor paralysis (flattened nasolabial fold, asymmetry of","confidence":0.5516266822814941,"confidence_rate":0.9906018419587327},{"cnt":[[1269,912],[1344,912],[1344,938],[1269,938]],"region":{"top_left_x":1269,"top_left_y":912,"width":76,"height":27},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"72823ff7491442fc8025af8bcbb7cbd3","type":"text","conversion_output":false,"parent_id":"1881f0c8b71848028cc6feb4bcfbc6e5","text":"smiling)","text_display":" smiling)","confidence":0.99951171875,"confidence_rate":0.9999624314366309},{"cnt":[[1204,939],[1238,939],[1238,974],[1204,974]],"region":{"top_left_x":1203,"top_left_y":939,"width":35,"height":35},"line":48,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"582e27eeb962485fb98cdcb265506355","type":"form_field","conversion_output":false,"parent_id":"1881f0c8b71848028cc6feb4bcfbc6e5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1237,950],[1781,950],[1781,978],[1237,978]],"region":{"top_left_x":1236,"top_left_y":950,"width":545,"height":28},"line":49,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"75d98b1d74b04e5aaac95e5dadebd045","type":"text","conversion_output":false,"parent_id":"1881f0c8b71848028cc6feb4bcfbc6e5","text":"2=Partial paralysis (total or near total paralysis of lower face)","text_display":" 2=Partial paralysis (total or near total paralysis of lower face)","confidence":0.98779296875,"confidence_rate":0.9998245561207684},{"cnt":[[1204,984],[1239,984],[1239,1019],[1204,1019]],"region":{"top_left_x":1203,"top_left_y":984,"width":37,"height":35},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"945b0aeeb7c14ac1b2a980c7d653a244","type":"form_field","conversion_output":false,"parent_id":"1881f0c8b71848028cc6feb4bcfbc6e5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1238,994],[1781,994],[1781,1020],[1238,1020]],"region":{"top_left_x":1237,"top_left_y":994,"width":544,"height":26},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f5658645d52e4166822eb7133821a7bb","type":"text","conversion_output":false,"parent_id":"1881f0c8b71848028cc6feb4bcfbc6e5","text":"3=Complete paralysis of one or both sides (absence of facial","text_display":" 3=Complete paralysis of one or both sides (absence of facial","confidence":1,"confidence_rate":1},{"cnt":[[1258,1019],[1612,1019],[1612,1047],[1258,1047]],"region":{"top_left_x":1258,"top_left_y":1018,"width":354,"height":30},"line":52,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0cf955a1f54d4e84aaf3c55ee2883867","type":"text","conversion_output":false,"parent_id":"1881f0c8b71848028cc6feb4bcfbc6e5","text":"movement in the upper and lower face)","text_display":" movement in the upper and lower face)","confidence":1,"confidence_rate":1},{"cnt":[[492,1264],[511,1264],[511,1290],[492,1290]],"region":{"top_left_x":491,"top_left_y":1264,"width":20,"height":27},"line":53,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1f6af21fb6cd4585b85e19ded04d5868","type":"simple_cell","conversion_output":false,"parent_id":"e0ff46a7aeff4c41bf70c75e511ad57e","text":"8","text_display":"8","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[541,1169],[1193,1169],[1193,1381],[541,1381]],"region":{"top_left_x":540,"top_left_y":1168,"width":653,"height":214},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8a6001467db64034886e77a6b7f986bd","type":"complex_cell","conversion_output":false,"parent_id":"e0ff46a7aeff4c41bf70c75e511ad57e","children_ids":["656a04ddde5040b38ae908fd1e9e7711","655eeb5e85be4220a17d238fd67a0f8e","26e79c9643414ed2ae94a5144f685be3","27d3be7c72dd428ba1460ebae97ac366","8917fbfaeb3e4c4ea27f3e8ec35a0a0f","459d566aa0bb4234891cfa1c710e7257","b52f394f2bbd4437931f930d1a163971","7b3f96a775fd4e2e982d14c4dc97e92a","4e236143146e4ba8a2534842e3e76835"],"text":"\\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the voice and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma Score \" 4 \"\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(5a) Motor Arm Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the arm falls before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the voice and pantomime but not noxious stimulation. Each imb is tested in tum, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma Score \" 4 \"\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.4468108460863144,"confidence_rate":0.9931121366412566},{"cnt":[[773,1171],[960,1171],[960,1200],[773,1200]],"region":{"top_left_x":772,"top_left_y":1171,"width":188,"height":29},"line":55,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"656a04ddde5040b38ae908fd1e9e7711","type":"text","conversion_output":false,"parent_id":"8a6001467db64034886e77a6b7f986bd","text":"(5a) Motor Arm Left","text_display":"(5a) Motor Arm Left","confidence":0.9460563659667969,"confidence_rate":0.997692120249451},{"cnt":[[553,1218],[1181,1218],[1181,1241],[553,1241]],"region":{"top_left_x":553,"top_left_y":1217,"width":628,"height":24},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"655eeb5e85be4220a17d238fd67a0f8e","type":"text","conversion_output":false,"parent_id":"8a6001467db64034886e77a6b7f986bd","text":"The limb is placed in the appropriate position: extend the arms (paims down) 90","text_display":"\nThe limb is placed in the appropriate position: extend the arms (paims down) 90","confidence":0.547793662953926,"confidence_rate":0.9927749429080626},{"cnt":[[546,1240],[1189,1240],[1189,1261],[546,1261]],"region":{"top_left_x":546,"top_left_y":1239,"width":643,"height":23},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"26e79c9643414ed2ae94a5144f685be3","type":"text","conversion_output":false,"parent_id":"8a6001467db64034886e77a6b7f986bd","text":"degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested","text_display":" degrees (if sitting) of 45 degrees (if supine) and the leg 30 degrees (always tested","confidence":0.8231349016255572,"confidence_rate":0.9979533060009497},{"cnt":[[568,1259],[1164,1259],[1164,1280],[568,1280]],"region":{"top_left_x":568,"top_left_y":1258,"width":597,"height":23},"line":58,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"27d3be7c72dd428ba1460ebae97ac366","type":"text","conversion_output":false,"parent_id":"8a6001467db64034886e77a6b7f986bd","text":"supine). Drift is scored if the arm falls before 10 seconds or the leg before 5","text_display":" supine). Drift is scored if the arm falls before 10 seconds or the leg before 5","confidence":0.8954554219617988,"confidence_rate":0.9987168374605995},{"cnt":[[568,1278],[1164,1278],[1164,1301],[568,1301]],"region":{"top_left_x":568,"top_left_y":1277,"width":597,"height":24},"line":59,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8917fbfaeb3e4c4ea27f3e8ec35a0a0f","type":"text","conversion_output":false,"parent_id":"8a6001467db64034886e77a6b7f986bd","text":"seconds. The aphasic patient is encouraged using urgency in the voice and","text_display":" seconds. The aphasic patient is encouraged using urgency in the voice and","confidence":0.47115182876586914,"confidence_rate":0.9903980005012075},{"cnt":[[546,1297],[1187,1297],[1187,1320],[546,1320]],"region":{"top_left_x":546,"top_left_y":1296,"width":642,"height":25},"line":60,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"459d566aa0bb4234891cfa1c710e7257","type":"text","conversion_output":false,"parent_id":"8a6001467db64034886e77a6b7f986bd","text":"pantomime but not noxious stimulation. Each imb is tested in tum, beginning with","text_display":" pantomime but not noxious stimulation. Each imb is tested in tum, beginning with","confidence":0.4468108460863144,"confidence_rate":0.9905668919431603},{"cnt":[[546,1319],[1187,1319],[1187,1342],[546,1342]],"region":{"top_left_x":546,"top_left_y":1318,"width":642,"height":24},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b52f394f2bbd4437931f930d1a163971","type":"text","conversion_output":false,"parent_id":"8a6001467db64034886e77a6b7f986bd","text":"the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or","text_display":" the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or","confidence":0.8795348910772224,"confidence_rate":0.9985424037347905},{"cnt":[[563,1338],[1170,1338],[1170,1361],[563,1361]],"region":{"top_left_x":562,"top_left_y":1337,"width":608,"height":24},"line":62,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7b3f96a775fd4e2e982d14c4dc97e92a","type":"text","conversion_output":false,"parent_id":"8a6001467db64034886e77a6b7f986bd","text":"hip can the examiner indicate no score and an explanation must be provided.","text_display":" hip can the examiner indicate no score and an explanation must be provided.","confidence":0.9985356330871582,"confidence_rate":0.9999816821659494},{"cnt":[[800,1360],[932,1360],[932,1377],[800,1377]],"region":{"top_left_x":800,"top_left_y":1359,"width":133,"height":19},"line":63,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4e236143146e4ba8a2534842e3e76835","type":"text","conversion_output":false,"parent_id":"8a6001467db64034886e77a6b7f986bd","text":"Coma Score \" 4 \"","text_display":" Coma Score \" 4 \"","confidence":0.5020893423954965,"confidence_rate":0.9717007586168322},{"cnt":[[1202,1126],[1784,1126],[1784,1431],[1202,1431]],"region":{"top_left_x":1202,"top_left_y":1126,"width":582,"height":305},"line":64,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e063b4cb7afd4f6c882794d0653f1368","type":"complex_cell","conversion_output":false,"parent_id":"e0ff46a7aeff4c41bf70c75e511ad57e","children_ids":["89096430ea904db7b89282352fdd9114","6dbf7fd804a54e778ff8bee90dec3b10","b8332647c52e4526b859457922168b68","aac355b427844d1ca9b5192a5ce02f28","2e662a28a8bb44bd865b46817346e8ce","840394792c524abb81285d6a3de0a03b","82136b2d52b0452583db9d039f3d4e5c","39a366fcbd5840f78a50202d19a1cb2f","b185d95350924128820e163b292c03cf","ab8fd9ab76a64477a5db42b3e6f5eb9b","803f1df42f204b14acc694fdb4c143d0","6cb68983897d49979cd4dd916af05da4","0139d9285ca44345adb4071bc3b1daf1","dfc0d2f32c9b422a991bf91bd6f2cd6e"],"text":"◯ \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ 1=Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f culed) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion","text_display":"◯ \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ 1=Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f culed) 90 degrees\n◯ 3=No effort against gravity, limb fails\n◯ 4=No movement\n◯ Amputation, joint fusion","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.3399416139693524,"confidence_rate":0.993590622785944},{"cnt":[[1204,1128],[1239,1128],[1239,1163],[1204,1163]],"region":{"top_left_x":1203,"top_left_y":1127,"width":37,"height":37},"line":65,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"89096430ea904db7b89282352fdd9114","type":"form_field","conversion_output":false,"parent_id":"e063b4cb7afd4f6c882794d0653f1368","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1239,1139],[1773,1139],[1773,1167],[1239,1167]],"region":{"top_left_x":1239,"top_left_y":1138,"width":534,"height":30},"line":66,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6dbf7fd804a54e778ff8bee90dec3b10","type":"text","conversion_output":false,"parent_id":"e063b4cb7afd4f6c882794d0653f1368","text":"\\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds","text_display":" \\(0=\\) No drift, limb holds 90 (or 45) degrees for full 10 seconds","confidence":0.8292329974019896,"confidence_rate":0.9974026275664597},{"cnt":[[1204,1171],[1239,1171],[1239,1207],[1204,1207]],"region":{"top_left_x":1203,"top_left_y":1171,"width":37,"height":36},"line":67,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b8332647c52e4526b859457922168b68","type":"form_field","conversion_output":false,"parent_id":"e063b4cb7afd4f6c882794d0653f1368","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1239,1182],[1781,1182],[1781,1211],[1239,1211]],"region":{"top_left_x":1239,"top_left_y":1182,"width":542,"height":29},"line":68,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"aac355b427844d1ca9b5192a5ce02f28","type":"text","conversion_output":false,"parent_id":"e063b4cb7afd4f6c882794d0653f1368","text":"1=Drift, limb holds 90 (or 45) degrees, but drifts down before","text_display":" 1=Drift, limb holds 90 (or 45) degrees, but drifts down before","confidence":0.6864430904388428,"confidence_rate":0.9946396758651911},{"cnt":[[1247,1210],[1541,1210],[1541,1233],[1247,1233]],"region":{"top_left_x":1247,"top_left_y":1209,"width":294,"height":24},"line":69,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2e662a28a8bb44bd865b46817346e8ce","type":"text","conversion_output":false,"parent_id":"e063b4cb7afd4f6c882794d0653f1368","text":"full 10 seconds; does not hit bed","text_display":" full 10 seconds; does not hit bed","confidence":0.99951171875,"confidence_rate":0.9999880878636791},{"cnt":[[1204,1240],[1239,1240],[1239,1272],[1204,1272]],"region":{"top_left_x":1203,"top_left_y":1239,"width":37,"height":34},"line":70,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"840394792c524abb81285d6a3de0a03b","type":"form_field","conversion_output":false,"parent_id":"e063b4cb7afd4f6c882794d0653f1368","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1238,1248],[1778,1248],[1778,1276],[1238,1276]],"region":{"top_left_x":1237,"top_left_y":1247,"width":542,"height":30},"line":71,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"82136b2d52b0452583db9d039f3d4e5c","type":"text","conversion_output":false,"parent_id":"e063b4cb7afd4f6c882794d0653f1368","text":"2=Some effort against gravity, limb cannot get to or maintain","text_display":" 2=Some effort against gravity, limb cannot get to or 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Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the anms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the am tals before 10 seconds of the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomine but not noxious stimusation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(5b) Motor Amm Right \\\\\nThe limb is placed in the appropriate position: extend the anms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested supine). Drift is scored if the am tals before 10 seconds of the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomine but not noxious stimusation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.1678295069248129,"confidence_rate":0.9925789288857544},{"cnt":[[767,1632],[968,1632],[968,1658],[767,1658]],"region":{"top_left_x":767,"top_left_y":1632,"width":201,"height":27},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"48904454abbe4478b42d80e7bc5fc18e","type":"text","conversion_output":false,"parent_id":"67dd4c840e484e59a8a828e8584c8342","text":"(5b) Motor Amm Right","text_display":"(5b) Motor Amm Right","confidence":0.9580078125,"confidence_rate":0.9982854975999765},{"cnt":[[553,1679],[1181,1679],[1181,1702],[553,1702]],"region":{"top_left_x":553,"top_left_y":1678,"width":628,"height":25},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a6b965d5ab994a1f93d15f1fa1b73a08","type":"text","conversion_output":false,"parent_id":"67dd4c840e484e59a8a828e8584c8342","text":"The limb is placed in the appropriate position: extend the anms (paims down) 90","text_display":"\nThe limb is placed in the appropriate position: extend the anms (paims down) 90","confidence":0.35459351328702804,"confidence_rate":0.9875863296505774},{"cnt":[[546,1698],[1187,1698],[1187,1721],[546,1721]],"region":{"top_left_x":546,"top_left_y":1697,"width":642,"height":25},"line":85,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"88f8da7267ba4d69bad254fd7baf1964","type":"text","conversion_output":false,"parent_id":"67dd4c840e484e59a8a828e8584c8342","text":"degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested","text_display":" degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested","confidence":0.571511563814056,"confidence_rate":0.9941281433251751},{"cnt":[[568,1720],[1164,1720],[1164,1743],[568,1743]],"region":{"top_left_x":568,"top_left_y":1719,"width":597,"height":24},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9a642edb3902402bb78edc3e12233433","type":"text","conversion_output":false,"parent_id":"67dd4c840e484e59a8a828e8584c8342","text":"supine). Drift is scored if the am tals before 10 seconds of the leg before 5","text_display":" supine). Drift is scored if the am tals before 10 seconds of the leg before 5","confidence":0.1678295069248129,"confidence_rate":0.978976443764025},{"cnt":[[568,1742],[1166,1742],[1166,1762],[568,1762]],"region":{"top_left_x":568,"top_left_y":1741,"width":598,"height":22},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b9fe4478315544c3aa3fdc15d72ca8bc","type":"text","conversion_output":false,"parent_id":"67dd4c840e484e59a8a828e8584c8342","text":"seconds. The aphasic patient is encouraged using urgency in the volce and","text_display":" seconds. The aphasic patient is encouraged using urgency in the volce and","confidence":0.9016950012273242,"confidence_rate":0.9986742263818889},{"cnt":[[544,1761],[1187,1761],[1187,1782],[544,1782]],"region":{"top_left_x":543,"top_left_y":1760,"width":645,"height":23},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3d42b66cf9184c2ba677696c622b5908","type":"text","conversion_output":false,"parent_id":"67dd4c840e484e59a8a828e8584c8342","text":"pantomine but not noxious stimusation. Each imb is tested in turn, beginning with","text_display":" pantomine but not noxious stimusation. Each imb is tested in turn, beginning with","confidence":0.6327917727682612,"confidence_rate":0.9946930404891683},{"cnt":[[546,1780],[1189,1780],[1189,1803],[546,1803]],"region":{"top_left_x":546,"top_left_y":1779,"width":643,"height":24},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9b7e134909774b3fbe758ec6607b0447","type":"text","conversion_output":false,"parent_id":"67dd4c840e484e59a8a828e8584c8342","text":"the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or","text_display":" the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or","confidence":0.49209579217395577,"confidence_rate":0.9919746279794576},{"cnt":[[563,1799],[1170,1799],[1170,1823],[563,1823]],"region":{"top_left_x":562,"top_left_y":1798,"width":608,"height":26},"line":90,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"68c8aa01677d4b2c91e3e2fc74cfce44","type":"text","conversion_output":false,"parent_id":"67dd4c840e484e59a8a828e8584c8342","text":"hip can the examiner indicate no score and an explanation must be provided.","text_display":" hip can the examiner indicate no score and an explanation must be 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seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint fusion","text_display":"◯ 0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds\n◯ \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before full 10 seconds; does not hit bed\n◯ 2=Some effort against gravity, limb cannot get to or maintain (f cued) 90 degrees\n◯ 3=No effort against gravity, limb falls\n◯ 4=No movement\n◯ Amputation, joint fusion","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.4146950929837816,"confidence_rate":0.9933374771679588},{"cnt":[[1204,1592],[1239,1592],[1239,1624],[1204,1624]],"region":{"top_left_x":1203,"top_left_y":1591,"width":37,"height":34},"line":93,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3cd7e8bf45514627ba515260ea3c11c5","type":"form_field","conversion_output":false,"parent_id":"550c78c8a835468585d0784830d80a65","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1239,1600],[1773,1600],[1773,1628],[1239,1628]],"region":{"top_left_x":1239,"top_left_y":1599,"width":534,"height":30},"line":94,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b489133738324bed9878ca7d64b3df42","type":"text","conversion_output":false,"parent_id":"550c78c8a835468585d0784830d80a65","text":"0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds","text_display":" 0 =No drift, limb holds 90 (or 45) degrees for full 10 seconds","confidence":0.4146950929837816,"confidence_rate":0.987849260599313},{"cnt":[[1204,1632],[1239,1632],[1239,1665],[1204,1665]],"region":{"top_left_x":1203,"top_left_y":1632,"width":37,"height":34},"line":95,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7d1f9ebb8b1742d1b80b3c07bdf9ba38","type":"form_field","conversion_output":false,"parent_id":"550c78c8a835468585d0784830d80a65","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1241,1642],[1781,1642],[1781,1669],[1241,1669]],"region":{"top_left_x":1240,"top_left_y":1641,"width":541,"height":29},"line":96,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1008a4bb2d444e67ab46d05708d2476a","type":"text","conversion_output":false,"parent_id":"550c78c8a835468585d0784830d80a65","text":"\\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before","text_display":" \\(1=\\) Drift, limb holds 90 (or 45) degrees, but drifts down before","confidence":0.9053194522857666,"confidence_rate":0.9985800460668548},{"cnt":[[1246,1669],[1541,1669],[1541,1694],[1246,1694]],"region":{"top_left_x":1246,"top_left_y":1669,"width":295,"height":25},"line":97,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0bf962cdd7754a36b136c4b2222dc972","type":"text","conversion_output":false,"parent_id":"550c78c8a835468585d0784830d80a65","text":"full 10 seconds; does not hit bed","text_display":" full 10 seconds; does not hit 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Right):","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[460,2378],[855,2378],[855,2413],[460,2413]],"region":{"top_left_x":459,"top_left_y":2378,"width":397,"height":35},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00ed45ccd5084fffa268e2a6bb004c8c","type":"text","conversion_output":true,"text":"Alteplase-Genentech, Inc.","text_display":"\n\nAlteplase-Genentech, Inc.","confidence":0.9941503966692835,"confidence_rate":0.9998044598113195},{"cnt":[[460,2415],[896,2415],[896,2447],[460,2447]],"region":{"top_left_x":459,"top_left_y":2414,"width":437,"height":34},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b0679003dd64df9baa677b1457e3e6b","type":"text","conversion_output":true,"text":"80/Protocol ML29093, Version 3","text_display":"\n80/Protocol ML29093, Version 3","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f1389404e9f4c1ba87a569e2ec6208e","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922086966757888,"confidence_rate":0.9998796716383385},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee89388f37b84050b0c142d713c77163","type":"page_info","conversion_output":false,"text":"625/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-290","page":290,"lines":[{"cnt":[[610,374],[1624,374],[1624,479],[610,479]],"region":{"top_left_x":610,"top_left_y":373,"width":1015,"height":107},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd500de4836a431dbd8a0438a2b06df3","type":"section_header","conversion_output":false,"children_ids":["b780378402ea42ca81f9aea6afb21b50","25512b5419a7495c8a9fa083e46ac54c"],"text":"","text_display":""},{"cnt":[[928,382],[1304,382],[1304,428],[928,428]],"region":{"top_left_x":928,"top_left_y":382,"width":377,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b780378402ea42ca81f9aea6afb21b50","type":"text","conversion_output":true,"parent_id":"dd500de4836a431dbd8a0438a2b06df3","text":"Appendix 7 (cont.)","text_display":"\n\n\\section*{Appendix 7 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[619,425],[1618,425],[1618,473],[619,473]],"region":{"top_left_x":618,"top_left_y":425,"width":1000,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25512b5419a7495c8a9fa083e46ac54c","type":"text","conversion_output":true,"parent_id":"dd500de4836a431dbd8a0438a2b06df3","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":" National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.9980478286743164,"confidence_rate":0.9999644719166708},{"cnt":[[464,524],[1800,524],[1800,2013],[464,2013]],"region":{"top_left_x":464,"top_left_y":524,"width":1337,"height":1490},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"03bc40a47f6842f4b18e8a311b203795","type":"table","conversion_output":true,"children_ids":["fdd656f0435c41dda6c0ed41e1107979","8c24d97bebc44e4fb75ee2a69f804844","014575fec7514ab99b393e9ecbb539f8","56b5544c996345e8b7a19f58d418250a","b3759874e0514114b309debd89183cc3","ab3fed2094ac409892fc3f5719707f02","76e7f1d0f3534ba0b5ba51656101a2ae","36a0b8ded87848999fc5cbf9903b9383","191f8a7c8ae545da94f66085d6d2a18b","2fe2d9f007314a97b2ac9848d428f918","b9138edb41f748c5aab3b72a6f5719fc","b1d47edf96394cd689770bc6480dc14e","acfcfbe417b1425baf1e0985f1031292","e0621de6d50a410cbf02643c1ed4f54f","b1705851f3dc4594a5d0eb6c256955f7","0d06380dd9694cefa2ce47cedf094d18","2a64adc94a27408dac1a3a6c2380a63f","678cf0c5677c43d5aa05718c6d3386f3","e7bd2821f1eb4a22b8dfa3fed383f4ee","ca9dce07e81946138a0543fd15120d43","b5a3dbb846474049b1024acd306a7145","134c2a18981942229f5f67f89fabc1b5","ee6e26bc78ed4312b7ef70974f2a9171","68eae6192b1f45c4afeb6e209b558f2e"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline 12 & \\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dorft Is scored if the arm falis before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimuiation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 13 & Explain if amputation/ joint fusion (Motor Leg Left): & \\\\\n\\hline 14 & \\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (If supine) and the leg 30 degrees (always tested suplne). Dritt is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \" 4 \".\n\\end{tabular} & ◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ 1=Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 15 & Explain if amputation/ joint fusion (Motor Leg Right): & \\\\\n\\hline 16 & \\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes operi. In case of visual defect, insure testing is done in intact visual field. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxla is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation or joint fusion, the examiner should record the score as untestable (UN), and ciearly write the explanation for this cholce. In case of bilndness, test by having the patient touch nose from extended arm postion. \\\\\nComa score \\({ }^{\\circ} 0^{\\circ}\\).\n\\end{tabular} & ◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion \\\\\n\\hline 17 & Explain if amputation or joint fusion (Limb Ataxia): & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 12 & \\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dorft Is scored if the arm falis before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimuiation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular} & ◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 13 & Explain if amputation/ joint fusion (Motor Leg Left): & \\\\\n\\hline 14 & \\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (If supine) and the leg 30 degrees (always tested suplne). Dritt is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \" 4 \".\n\\end{tabular} & ◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ 1=Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion \\\\\n\\hline 15 & Explain if amputation/ joint fusion (Motor Leg Right): & \\\\\n\\hline 16 & \\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes operi. In case of visual defect, insure testing is done in intact visual field. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxla is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation or joint fusion, the examiner should record the score as untestable (UN), and ciearly write the explanation for this cholce. In case of bilndness, test by having the patient touch nose from extended arm postion. \\\\\nComa score \\({ }^{\\circ} 0^{\\circ}\\).\n\\end{tabular} & ◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion \\\\\n\\hline 17 & Explain if amputation or joint fusion (Limb Ataxia): & \\\\\n\\hline\n\\end{tabular}","confidence":0.086693336048234,"confidence_rate":0.9975920479473379},{"cnt":[[487,524],[521,524],[521,2012],[487,2012]],"region":{"top_left_x":487,"top_left_y":524,"width":35,"height":1489},"line":5,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fdd656f0435c41dda6c0ed41e1107979","type":"table_column","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"","text_display":""},{"cnt":[[536,524],[1098,524],[1098,2012],[536,2012]],"region":{"top_left_x":536,"top_left_y":524,"width":563,"height":1489},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8c24d97bebc44e4fb75ee2a69f804844","type":"table_column","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"","text_display":""},{"cnt":[[1100,524],[1778,524],[1778,2014],[1100,2014]],"region":{"top_left_x":1099,"top_left_y":524,"width":679,"height":1490},"line":7,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"014575fec7514ab99b393e9ecbb539f8","type":"table_column","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"","text_display":""},{"cnt":[[464,584],[1801,584],[1801,870],[464,870]],"region":{"top_left_x":464,"top_left_y":584,"width":1337,"height":287},"line":8,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"56b5544c996345e8b7a19f58d418250a","type":"table_row","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"","text_display":""},{"cnt":[[464,947],[1800,947],[1800,981],[464,981]],"region":{"top_left_x":464,"top_left_y":946,"width":1336,"height":35},"line":9,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b3759874e0514114b309debd89183cc3","type":"table_row","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"","text_display":""},{"cnt":[[464,1064],[1801,1064],[1801,1351],[464,1351]],"region":{"top_left_x":464,"top_left_y":1064,"width":1337,"height":287},"line":10,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ab3fed2094ac409892fc3f5719707f02","type":"table_row","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"","text_display":""},{"cnt":[[464,1443],[1800,1443],[1800,1478],[464,1478]],"region":{"top_left_x":464,"top_left_y":1443,"width":1336,"height":35},"line":11,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"76e7f1d0f3534ba0b5ba51656101a2ae","type":"table_row","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"","text_display":""},{"cnt":[[464,1574],[1801,1574],[1801,1838],[464,1838]],"region":{"top_left_x":464,"top_left_y":1574,"width":1337,"height":264},"line":12,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"36a0b8ded87848999fc5cbf9903b9383","type":"table_row","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"","text_display":""},{"cnt":[[464,1929],[1800,1929],[1800,1966],[464,1966]],"region":{"top_left_x":464,"top_left_y":1929,"width":1336,"height":37},"line":13,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"191f8a7c8ae545da94f66085d6d2a18b","type":"table_row","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"","text_display":""},{"cnt":[[486,711],[519,711],[519,737],[486,737]],"region":{"top_left_x":485,"top_left_y":710,"width":34,"height":27},"line":14,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2fe2d9f007314a97b2ac9848d428f918","type":"simple_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"12","text_display":"12","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[537,606],[1094,604],[1095,843],[538,845]],"region":{"top_left_x":536,"top_left_y":604,"width":559,"height":242},"line":15,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b9138edb41f748c5aab3b72a6f5719fc","type":"complex_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","children_ids":["d134c89f23e84288a769432114cae869","549e4a413d8c4b7f8e8daaca146cfceb","d339152da1cc483f9362c16f90058166","6956f83fcb9344b086db210afe997f26","38ada0d7a1674b608784364dd4fba768","7a8f35db0e45465e81379c0527568db5","e4953beb598b4609b37ee4350ba185ce","bfa83649a6aa4bfda3e4ac88dceccc7d","65bdbe622a7f4d679b0c9c72bc7e38c4","7e10922c627344acba1fe6970a04b0fd"],"text":"\\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dorft Is scored if the arm falis before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimuiation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(6a) Motor Leg Left \\\\\nThe limb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30 degrees (always tested suplne). Dorft Is scored if the arm falis before 10 seconds or the leg before 5 seconds. The aphasic pattent is encouraged using urgency in the volce and pantomime but not noxious stimuiation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \"4\".\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.086693336048234,"confidence_rate":0.9908228124136548},{"cnt":[[726,611],[910,611],[910,639],[726,639]],"region":{"top_left_x":725,"top_left_y":611,"width":186,"height":28},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d134c89f23e84288a769432114cae869","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"(6a) Motor Leg Left","text_display":"(6a) Motor Leg Left","confidence":1,"confidence_rate":1},{"cnt":[[543,681],[543,656],[1089,658],[1089,682]],"region":{"top_left_x":543,"top_left_y":656,"width":546,"height":27},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"549e4a413d8c4b7f8e8daaca146cfceb","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"The limb is placed in the appropriate position: extend the arms (paims","text_display":"\nThe limb is placed in the appropriate position: extend the arms (paims","confidence":0.9225106988378888,"confidence_rate":0.9989251606476844},{"cnt":[[551,678],[1083,678],[1083,700],[551,700]],"region":{"top_left_x":551,"top_left_y":678,"width":533,"height":22},"line":18,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d339152da1cc483f9362c16f90058166","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30","text_display":" down) 90 degrees (if sitting) or 45 degrees (if supine) and the leg 30","confidence":0.6838837745649731,"confidence_rate":0.995261670271797},{"cnt":[[549,697],[1087,697],[1087,719],[549,719]],"region":{"top_left_x":548,"top_left_y":697,"width":540,"height":23},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6956f83fcb9344b086db210afe997f26","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"degrees (always tested suplne). Dorft Is scored if the arm falis before","text_display":" degrees (always tested suplne). Dorft Is scored if the arm falis before","confidence":0.086693336048234,"confidence_rate":0.9683361111205308},{"cnt":[[570,716],[1067,716],[1067,740],[570,740]],"region":{"top_left_x":570,"top_left_y":716,"width":497,"height":24},"line":20,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"38ada0d7a1674b608784364dd4fba768","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"10 seconds or the leg before 5 seconds. The aphasic pattent is","text_display":" 10 seconds or the leg before 5 seconds. The aphasic pattent is","confidence":0.6107778735941104,"confidence_rate":0.9928802211894903},{"cnt":[[570,740],[1063,740],[1063,761],[570,761]],"region":{"top_left_x":570,"top_left_y":739,"width":493,"height":23},"line":21,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7a8f35db0e45465e81379c0527568db5","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"encouraged using urgency in the volce and pantomime but not","text_display":" encouraged using urgency in the volce and pantomime but not","confidence":0.6916332565676351,"confidence_rate":0.9942556335813695},{"cnt":[[557,759],[1077,759],[1077,782],[557,782]],"region":{"top_left_x":556,"top_left_y":758,"width":521,"height":24},"line":22,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e4953beb598b4609b37ee4350ba185ce","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"noxious stimuiation. Each imb is tested in turn, beginning with the","text_display":" noxious stimuiation. Each imb is tested in turn, beginning with the","confidence":0.629642492652989,"confidence_rate":0.9935955535003758},{"cnt":[[559,778],[1077,778],[1077,801],[559,801]],"region":{"top_left_x":559,"top_left_y":777,"width":518,"height":24},"line":23,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bfa83649a6aa4bfda3e4ac88dceccc7d","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"non-paretic arm. Only in cases of amputation or joint fusion at the","text_display":" non-paretic arm. Only in cases of amputation or joint fusion at the","confidence":0.6944634749220313,"confidence_rate":0.9949486938882821},{"cnt":[[542,797],[1093,797],[1093,820],[542,820]],"region":{"top_left_x":541,"top_left_y":796,"width":552,"height":25},"line":24,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"65bdbe622a7f4d679b0c9c72bc7e38c4","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"shoulder or hip can the examiner indicate no score and an explanation","text_display":" shoulder or hip can the examiner indicate no score and an explanation","confidence":0.9229414206929505,"confidence_rate":0.9989169448645463},{"cnt":[[674,819],[962,819],[962,842],[674,842]],"region":{"top_left_x":674,"top_left_y":818,"width":288,"height":24},"line":25,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7e10922c627344acba1fe6970a04b0fd","type":"text","conversion_output":false,"parent_id":"b9138edb41f748c5aab3b72a6f5719fc","text":"must be provided. Coma score \"4\".","text_display":" must be provided. Coma score \"4\".","confidence":0.335816084622103,"confidence_rate":0.9716928043610998},{"cnt":[[1101,587],[1770,587],[1770,869],[1101,869]],"region":{"top_left_x":1101,"top_left_y":586,"width":669,"height":284},"line":26,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b1d47edf96394cd689770bc6480dc14e","type":"complex_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","children_ids":["d552432369d24098872923a4d14039f8","69d904b54eef4c708ab7026e75ec6cc8","94e6f0b3ba5b4a378052640652e4671a","b8c7b3a74903490b9a70633ce8aa388e","b22f5375368c49a7a3e69a061004221e","271ccae0bfa74a0c81030345c6df7b7e","e92cc36c0bd74fbdb2fb15c87e234b63","7de0dee4f54e47a3aad307fa82a6fb9e","af91e647dca54e128510abefedc9d0ea","68365c909daf4679b0cdec3f6af5dfba","8545f504fb704ba4994dfac39db27877","b6168f0bb7bf48cdb6dbc54ce17de6b5","53a2a37a98af4c2aa4a4a6c0a3722c1b"],"text":"◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion","text_display":"◯ 0=No drift, leg holds 30 degrees position for full 5 seconds\n◯ \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity, leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity; leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.6212785243988037,"confidence_rate":0.9971455953402185},{"cnt":[[1105,589],[1138,589],[1138,625],[1105,625]],"region":{"top_left_x":1105,"top_left_y":589,"width":33,"height":36},"line":27,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d552432369d24098872923a4d14039f8","type":"form_field","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1138,598],[1660,598],[1660,629],[1138,629]],"region":{"top_left_x":1137,"top_left_y":597,"width":524,"height":33},"line":28,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"69d904b54eef4c708ab7026e75ec6cc8","type":"text","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"0=No drift, leg holds 30 degrees position for full 5 seconds","text_display":" 0=No drift, leg holds 30 degrees position for full 5 seconds","confidence":0.9726946230512112,"confidence_rate":0.9996101450697904},{"cnt":[[1102,633],[1138,633],[1138,669],[1102,669]],"region":{"top_left_x":1102,"top_left_y":633,"width":36,"height":36},"line":29,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"94e6f0b3ba5b4a378052640652e4671a","type":"form_field","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,641],[1767,641],[1767,671],[1138,671]],"region":{"top_left_x":1137,"top_left_y":641,"width":630,"height":31},"line":30,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b8c7b3a74903490b9a70633ce8aa388e","type":"text","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"\\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed","text_display":" \\(1=\\) Drift, leg falls by the end of the 5 second period but does not hit bed","confidence":0.9951229095458984,"confidence_rate":0.9999396435218886},{"cnt":[[1104,674],[1138,674],[1138,710],[1104,710]],"region":{"top_left_x":1103,"top_left_y":674,"width":35,"height":36},"line":31,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b22f5375368c49a7a3e69a061004221e","type":"form_field","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,685],[1745,685],[1745,714],[1138,714]],"region":{"top_left_x":1137,"top_left_y":684,"width":608,"height":30},"line":32,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"271ccae0bfa74a0c81030345c6df7b7e","type":"text","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"2=Some effort against gravity, leg falls to bed by 5 seconds, but has","text_display":" 2=Some effort against gravity, leg falls to bed by 5 seconds, but has","confidence":0.7580409049987793,"confidence_rate":0.9964088282767717},{"cnt":[[1146,712],[1389,712],[1389,738],[1146,738]],"region":{"top_left_x":1146,"top_left_y":712,"width":243,"height":27},"line":33,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e92cc36c0bd74fbdb2fb15c87e234b63","type":"text","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"some effort against gravity","text_display":" some effort against gravity","confidence":1,"confidence_rate":1},{"cnt":[[1104,742],[1138,742],[1138,778],[1104,778]],"region":{"top_left_x":1103,"top_left_y":742,"width":35,"height":36},"line":34,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7de0dee4f54e47a3aad307fa82a6fb9e","type":"form_field","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,750],[1633,750],[1633,782],[1138,782]],"region":{"top_left_x":1137,"top_left_y":750,"width":497,"height":32},"line":35,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"af91e647dca54e128510abefedc9d0ea","type":"text","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"3=No effort against gravity; leg falls to bed immediately","text_display":" 3=No effort against gravity; leg falls to bed immediately","confidence":0.6212785243988037,"confidence_rate":0.9923523642802096},{"cnt":[[1102,783],[1137,783],[1137,817],[1102,817]],"region":{"top_left_x":1102,"top_left_y":783,"width":35,"height":35},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"68365c909daf4679b0cdec3f6af5dfba","type":"form_field","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,794],[1295,794],[1295,820],[1138,820]],"region":{"top_left_x":1137,"top_left_y":794,"width":158,"height":27},"line":37,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8545f504fb704ba4994dfac39db27877","type":"text","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"4=No movement","text_display":" 4=No movement","confidence":0.8614656443683089,"confidence_rate":0.9917497713419489},{"cnt":[[1102,827],[1137,827],[1137,861],[1102,861]],"region":{"top_left_x":1102,"top_left_y":826,"width":35,"height":35},"line":38,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b6168f0bb7bf48cdb6dbc54ce17de6b5","type":"form_field","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,838],[1352,838],[1352,866],[1138,866]],"region":{"top_left_x":1137,"top_left_y":837,"width":216,"height":30},"line":39,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"53a2a37a98af4c2aa4a4a6c0a3722c1b","type":"text","conversion_output":false,"parent_id":"b1d47edf96394cd689770bc6480dc14e","text":"Amputation, joint fusion","text_display":" Amputation, joint fusion","confidence":1,"confidence_rate":1},{"cnt":[[486,952],[519,952],[519,977],[486,977]],"region":{"top_left_x":485,"top_left_y":952,"width":34,"height":25},"line":40,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"acfcfbe417b1425baf1e0985f1031292","type":"simple_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"13","text_display":"13","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[641,951],[1093,951],[1093,980],[641,980]],"region":{"top_left_x":641,"top_left_y":950,"width":452,"height":30},"line":41,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e0621de6d50a410cbf02643c1ed4f54f","type":"simple_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"Explain if amputation/ joint fusion (Motor Leg Left):","text_display":"Explain if amputation/ joint fusion (Motor Leg Left):","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999915793372107},{"cnt":[[486,1192],[519,1192],[519,1217],[486,1217]],"region":{"top_left_x":485,"top_left_y":1192,"width":34,"height":25},"line":42,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b1705851f3dc4594a5d0eb6c256955f7","type":"simple_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"14","text_display":"14","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[540,1085],[1094,1085],[1094,1323],[540,1323]],"region":{"top_left_x":540,"top_left_y":1084,"width":555,"height":240},"line":43,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0d06380dd9694cefa2ce47cedf094d18","type":"complex_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","children_ids":["d9122c1ddac04da3962c5fdb708c92be","b33386426c234b43bdbe2724b94b1b80","ac201bce00244faaabeaeaa25e97b2e4","f74a36117791412e8bfa9d84a042a549","4422abe81ed148c4bf68e9a3d9839693","e0554e8702034c12a503f489c687fa0b","07f9c74a63f342f78f6644f1dc523f61","71f8e18c43e242aeb71f3ab852b5b45d","f08597ea9f5b49b2adea82b069346a50","3969068a209b47859f6c14f3c6b4ed17"],"text":"\\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (If supine) and the leg 30 degrees (always tested suplne). Dritt is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \" 4 \".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(6b) Motor Leg Right \\\\\nThe imb is placed in the appropriate position: extend the arms (paims down) 90 degrees (if sitting) or 45 degrees (If supine) and the leg 30 degrees (always tested suplne). Dritt is scored if the arm fals before 10 seconds or the leg before 5 seconds. The aphasic patient is encouraged using urgency in the volce and pantomime but not noxious stimulation. Each imb is tested in turn, beginning with the non-paretic arm. Only in cases of amputation or joint fusion at the shoulder or hip can the examiner indicate no score and an explanation must be provided. Coma score \" 4 \".\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.37407709255187543,"confidence_rate":0.9925342372131943},{"cnt":[[720,1091],[916,1091],[916,1120],[720,1120]],"region":{"top_left_x":720,"top_left_y":1091,"width":196,"height":30},"line":44,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d9122c1ddac04da3962c5fdb708c92be","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"(6b) Motor Leg Right","text_display":"(6b) Motor Leg Right","confidence":1,"confidence_rate":1},{"cnt":[[540,1138],[1087,1138],[1087,1161],[540,1161]],"region":{"top_left_x":540,"top_left_y":1137,"width":548,"height":25},"line":45,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b33386426c234b43bdbe2724b94b1b80","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"The imb is placed in the appropriate position: extend the arms (paims","text_display":"\nThe imb is placed in the appropriate position: extend the arms (paims","confidence":0.8680571494363676,"confidence_rate":0.9980896955245461},{"cnt":[[542,1157],[1077,1157],[1077,1182],[542,1182]],"region":{"top_left_x":541,"top_left_y":1156,"width":536,"height":26},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ac201bce00244faaabeaeaa25e97b2e4","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"down) 90 degrees (if sitting) or 45 degrees (If supine) and the leg 30","text_display":" down) 90 degrees (if sitting) or 45 degrees (If supine) and the leg 30","confidence":0.37407709255187543,"confidence_rate":0.9877840607045173},{"cnt":[[542,1179],[1081,1179],[1081,1202],[542,1202]],"region":{"top_left_x":541,"top_left_y":1178,"width":540,"height":24},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f74a36117791412e8bfa9d84a042a549","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"degrees (always tested suplne). Dritt is scored if the arm fals before","text_display":" degrees (always tested suplne). Dritt is scored if the arm fals before","confidence":0.5072475870620419,"confidence_rate":0.9909907479578197},{"cnt":[[543,1198],[1041,1198],[1041,1221],[543,1221]],"region":{"top_left_x":543,"top_left_y":1197,"width":499,"height":25},"line":48,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4422abe81ed148c4bf68e9a3d9839693","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"10 seconds or the leg before 5 seconds. The aphasic patient is","text_display":" 10 seconds or the leg before 5 seconds. The aphasic patient is","confidence":0.7598895202537133,"confidence_rate":0.9960284550016202},{"cnt":[[543,1220],[1033,1220],[1033,1243],[543,1243]],"region":{"top_left_x":543,"top_left_y":1219,"width":490,"height":24},"line":49,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e0554e8702034c12a503f489c687fa0b","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"encouraged using urgency in the volce and pantomime but not","text_display":" encouraged using urgency in the volce and pantomime but not","confidence":0.7826070772182392,"confidence_rate":0.9961772546463684},{"cnt":[[542,1239],[1063,1239],[1063,1262],[542,1262]],"region":{"top_left_x":541,"top_left_y":1238,"width":522,"height":25},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"07f9c74a63f342f78f6644f1dc523f61","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"noxious stimulation. Each imb is tested in turn, beginning with the","text_display":" noxious stimulation. Each imb is tested in turn, beginning with the","confidence":0.5716686153534939,"confidence_rate":0.9922634738499706},{"cnt":[[542,1258],[1060,1258],[1060,1281],[542,1281]],"region":{"top_left_x":541,"top_left_y":1257,"width":520,"height":25},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"71f8e18c43e242aeb71f3ab852b5b45d","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"non-paretic arm. Only in cases of amputation or joint fusion at the","text_display":" non-paretic arm. Only in cases of amputation or joint fusion at the","confidence":0.7105460456177322,"confidence_rate":0.9952651127803348},{"cnt":[[543,1277],[1093,1277],[1093,1302],[543,1302]],"region":{"top_left_x":543,"top_left_y":1277,"width":550,"height":25},"line":52,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f08597ea9f5b49b2adea82b069346a50","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"shoulder or hip can the examiner indicate no score and an explanation","text_display":" shoulder or hip can the examiner indicate no score and an explanation","confidence":0.5038528423756361,"confidence_rate":0.9907796484833847},{"cnt":[[543,1296],[827,1296],[827,1322],[543,1322]],"region":{"top_left_x":543,"top_left_y":1296,"width":284,"height":27},"line":53,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3969068a209b47859f6c14f3c6b4ed17","type":"text","conversion_output":false,"parent_id":"0d06380dd9694cefa2ce47cedf094d18","text":"must be provided. Coma score \" 4 \".","text_display":" must be provided. Coma score \" 4 \".","confidence":0.38664254943056586,"confidence_rate":0.9781434473441367},{"cnt":[[1101,1067],[1770,1067],[1770,1349],[1101,1349]],"region":{"top_left_x":1101,"top_left_y":1066,"width":669,"height":284},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2a64adc94a27408dac1a3a6c2380a63f","type":"complex_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","children_ids":["2ff0a6030482417395f272c2a218c421","2fd14dcc542d4daaa4dddb69ad6c4899","fde89f2e452f4d9d80ec73ef25b969f3","4f450d402b5b4fedb8d3ff3ba706bc94","34178dcdc63d4835a8e80a52f50e47ef","74fd8968d53241439a582cb5679b6979","ea3c2c8a289d4af285f089f01334b34d","123bab4f10e44ff59522eaadc0e347b7","c2ec6d598af244b59e81bf603e0f1716","33b32f2ad94347219b18c40a9d7ca31a","d69747d0ee21403e9e71291f59ec4deb","a8694e249c264e19960191bf24e2ed33","950c73a2273642a9a50017bc7cb8c6ec"],"text":"◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ 1=Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint fusion","text_display":"◯ \\(0=\\) No drift, leg holds 30 degrees position for full 5 seconds\n◯ 1=Drift, leg falls by the end of the 5 second period but does not hit bed\n◯ 2=Some effort against gravity; leg falls to bed by 5 seconds, but has some effort against gravity\n◯ 3=No effort against gravity, leg falls to bed immediately\n◯ 4=No movement\n◯ Amputation, joint 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position for full 5 seconds","confidence":0.672987234313041,"confidence_rate":0.9944376553626605},{"cnt":[[1104,1113],[1138,1113],[1138,1149],[1104,1149]],"region":{"top_left_x":1103,"top_left_y":1113,"width":35,"height":36},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fde89f2e452f4d9d80ec73ef25b969f3","type":"form_field","conversion_output":false,"parent_id":"2a64adc94a27408dac1a3a6c2380a63f","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,1122],[1767,1122],[1767,1153],[1138,1153]],"region":{"top_left_x":1137,"top_left_y":1121,"width":630,"height":32},"line":58,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4f450d402b5b4fedb8d3ff3ba706bc94","type":"text","conversion_output":false,"parent_id":"2a64adc94a27408dac1a3a6c2380a63f","text":"1=Drift, leg falls by the end of the 5 second period but does not hit bed","text_display":" 1=Drift, leg falls by the end of the 5 second period but does not hit 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has","confidence":0.5661296844482422,"confidence_rate":0.9926385009453678},{"cnt":[[1146,1192],[1389,1192],[1389,1218],[1146,1218]],"region":{"top_left_x":1146,"top_left_y":1192,"width":243,"height":27},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ea3c2c8a289d4af285f089f01334b34d","type":"text","conversion_output":false,"parent_id":"2a64adc94a27408dac1a3a6c2380a63f","text":"some effort against gravity","text_display":" some effort against 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immediately","confidence":0.9130859375,"confidence_rate":0.9985345381247832},{"cnt":[[1102,1263],[1137,1263],[1137,1297],[1102,1297]],"region":{"top_left_x":1102,"top_left_y":1263,"width":35,"height":35},"line":64,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"33b32f2ad94347219b18c40a9d7ca31a","type":"form_field","conversion_output":false,"parent_id":"2a64adc94a27408dac1a3a6c2380a63f","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,1274],[1295,1274],[1295,1300],[1138,1300]],"region":{"top_left_x":1137,"top_left_y":1274,"width":158,"height":27},"line":65,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d69747d0ee21403e9e71291f59ec4deb","type":"text","conversion_output":false,"parent_id":"2a64adc94a27408dac1a3a6c2380a63f","text":"4=No movement","text_display":" 4=No movement","confidence":0.9416241539474868,"confidence_rate":0.9966639619074763},{"cnt":[[1102,1307],[1138,1307],[1138,1344],[1102,1344]],"region":{"top_left_x":1102,"top_left_y":1307,"width":36,"height":37},"line":66,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a8694e249c264e19960191bf24e2ed33","type":"form_field","conversion_output":false,"parent_id":"2a64adc94a27408dac1a3a6c2380a63f","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,1318],[1352,1318],[1352,1347],[1138,1347]],"region":{"top_left_x":1137,"top_left_y":1317,"width":216,"height":30},"line":67,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"950c73a2273642a9a50017bc7cb8c6ec","type":"text","conversion_output":false,"parent_id":"2a64adc94a27408dac1a3a6c2380a63f","text":"Amputation, joint fusion","text_display":" Amputation, joint fusion","confidence":1,"confidence_rate":1},{"cnt":[[486,1446],[519,1446],[519,1473],[486,1473]],"region":{"top_left_x":485,"top_left_y":1446,"width":34,"height":28},"line":68,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"678cf0c5677c43d5aa05718c6d3386f3","type":"simple_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"15","text_display":"15","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[628,1446],[1093,1446],[1093,1476],[628,1476]],"region":{"top_left_x":627,"top_left_y":1446,"width":466,"height":31},"line":69,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e7bd2821f1eb4a22b8dfa3fed383f4ee","type":"simple_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"Explain if amputation/ joint fusion (Motor Leg Right):","text_display":"Explain if amputation/ joint fusion (Motor Leg Right):","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[486,1694],[519,1694],[519,1720],[486,1720]],"region":{"top_left_x":485,"top_left_y":1694,"width":34,"height":27},"line":70,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ca9dce07e81946138a0543fd15120d43","type":"simple_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"16","text_display":"16","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[540,1576],[1093,1576],[1093,1835],[540,1835]],"region":{"top_left_x":540,"top_left_y":1575,"width":553,"height":260},"line":71,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b5a3dbb846474049b1024acd306a7145","type":"complex_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","children_ids":["25359b8ac48a4456b75e00007be927d3","8a0722be64fa4522a92d2047293d35c2","86afbad3f25c4a44922593e5ce7a18b3","51f223da9fa6400189b8a0910c05960e","fa156ea65043428eb1d309f0341d5fcd","dc1e3e96466e485bba597f28c0a8c322","63b5477f76b347c7a07a641cf198a409","91967f1864724bd988a4c04b29d0b917","386971d8a1cc4839a9943cbdaf7a2214","995cbda227ba4cf3939d8f26dfada516","e9fc0a33ad3748829e8a589018765872"],"text":"\\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes operi. In case of visual defect, insure testing is done in intact visual field. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxla is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation or joint fusion, the examiner should record the score as untestable (UN), and ciearly write the explanation for this cholce. In case of bilndness, test by having the patient touch nose from extended arm postion. \\\\\nComa score \\({ }^{\\circ} 0^{\\circ}\\).\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(7) Limb Ataxia \\\\\nThis item is aimed at finding evidence of a unilateral cerebelar lesion. Test with eyes operi. In case of visual defect, insure testing is done in intact visual field. The finger-nose-finger and heel-shin tests are performed on both sides, and ataxla is scored only if present put of proportion to weakness. Ataxla is absent in the patient who cannot understand or is paralyzed. Only in the case of amputation or joint fusion, the examiner should record the score as untestable (UN), and ciearly write the explanation for this cholce. In case of bilndness, test by having the patient touch nose from extended arm postion. \\\\\nComa score \\({ }^{\\circ} 0^{\\circ}\\).\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.22991427390547867,"confidence_rate":0.9920099295725219},{"cnt":[[742,1579],[891,1579],[891,1609],[742,1609]],"region":{"top_left_x":742,"top_left_y":1578,"width":149,"height":31},"line":72,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"25359b8ac48a4456b75e00007be927d3","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"(7) Limb Ataxia","text_display":"(7) Limb Ataxia","confidence":1,"confidence_rate":1},{"cnt":[[543,1626],[1090,1626],[1090,1651],[543,1651]],"region":{"top_left_x":543,"top_left_y":1626,"width":548,"height":25},"line":73,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8a0722be64fa4522a92d2047293d35c2","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"This item is aimed at finding evidence of a unilateral cerebelar lesion.","text_display":"\nThis item is aimed at finding evidence of a unilateral cerebelar lesion.","confidence":0.904721430108261,"confidence_rate":0.9987004789447747},{"cnt":[[543,1648],[1090,1648],[1090,1674],[543,1674]],"region":{"top_left_x":543,"top_left_y":1648,"width":548,"height":26},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"86afbad3f25c4a44922593e5ce7a18b3","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"Test with eyes operi. In case of visual defect, insure testing is done in","text_display":" Test with eyes operi. In case of visual defect, insure testing is done in","confidence":0.46258443127641835,"confidence_rate":0.9901650139030165},{"cnt":[[566,1670],[1068,1670],[1068,1693],[566,1693]],"region":{"top_left_x":566,"top_left_y":1669,"width":503,"height":25},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"51f223da9fa6400189b8a0910c05960e","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"intact visual field. The finger-nose-finger and heel-shin tests are","text_display":" intact visual field. The finger-nose-finger and heel-shin tests are","confidence":0.3108479234556473,"confidence_rate":0.9839024797788719},{"cnt":[[554,1689],[1079,1689],[1079,1712],[554,1712]],"region":{"top_left_x":554,"top_left_y":1689,"width":526,"height":24},"line":76,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fa156ea65043428eb1d309f0341d5fcd","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"performed on both sides, and ataxla is scored only if present put of","text_display":" performed on both sides, and ataxla is scored only if present put of","confidence":0.7731980395942413,"confidence_rate":0.9964826378989021},{"cnt":[[554,1708],[1082,1708],[1082,1731],[554,1731]],"region":{"top_left_x":554,"top_left_y":1708,"width":528,"height":24},"line":77,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"dc1e3e96466e485bba597f28c0a8c322","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"proportion to weakness. Ataxla is absent in the patient who cannot","text_display":" proportion to weakness. Ataxla is absent in the patient who cannot","confidence":0.6659083366394043,"confidence_rate":0.9942895605509054},{"cnt":[[557,1727],[1079,1727],[1079,1752],[557,1752]],"region":{"top_left_x":556,"top_left_y":1727,"width":524,"height":25},"line":78,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"63b5477f76b347c7a07a641cf198a409","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"understand or is paralyzed. Only in the case of amputation or joint","text_display":" understand or is paralyzed. Only in the case of amputation or joint","confidence":0.7001851840428568,"confidence_rate":0.9950620869105703},{"cnt":[[546,1749],[1087,1749],[1087,1772],[546,1772]],"region":{"top_left_x":545,"top_left_y":1749,"width":543,"height":24},"line":79,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"91967f1864724bd988a4c04b29d0b917","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"fusion, the examiner should record the score as untestable (UN), and","text_display":" fusion, the examiner should record the score as untestable (UN), and","confidence":0.97412109375,"confidence_rate":0.9996408911137297},{"cnt":[[546,1771],[1089,1771],[1089,1791],[546,1791]],"region":{"top_left_x":545,"top_left_y":1770,"width":544,"height":22},"line":80,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"386971d8a1cc4839a9943cbdaf7a2214","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"ciearly write the explanation for this cholce. In case of bilndness, test","text_display":" ciearly write the explanation for this cholce. In case of bilndness, test","confidence":0.4564191144311156,"confidence_rate":0.9899946999041956},{"cnt":[[576,1790],[1057,1790],[1057,1813],[576,1813]],"region":{"top_left_x":575,"top_left_y":1789,"width":483,"height":25},"line":81,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"995cbda227ba4cf3939d8f26dfada516","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"by having the patient touch nose from extended arm postion.","text_display":" by having the patient touch nose from extended arm postion.","confidence":0.22991427390547867,"confidence_rate":0.9772922791024763},{"cnt":[[750,1809],[883,1809],[883,1830],[750,1830]],"region":{"top_left_x":750,"top_left_y":1809,"width":133,"height":21},"line":82,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e9fc0a33ad3748829e8a589018765872","type":"text","conversion_output":false,"parent_id":"b5a3dbb846474049b1024acd306a7145","text":"Coma score \\({ }^{\\circ} 0^{\\circ}\\).","text_display":"\nComa score \\({ }^{\\circ} 0^{\\circ}\\).","confidence":0.6044949703221559,"confidence_rate":0.9868409804493622},{"cnt":[[1102,1622],[1422,1622],[1422,1794],[1102,1794]],"region":{"top_left_x":1102,"top_left_y":1622,"width":320,"height":173},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"134c2a18981942229f5f67f89fabc1b5","type":"complex_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","children_ids":["ab80c04f7fd94ccf90dfa1ef3b62ae06","942da48391704d919b91a3c5ca84a460","367f1eb0885249caa4170e6d494a12c7","b2f2cbddcd68438dbff22ad099e6474f","a88bfecd2e434a48b8cffc612718111f","ff742b93dc33411bb52bc8723041d9d6","b44e9d25693f45a7bd6a0e36ca0c690c","45a40b94998b4179a7dde66c0b1c38cc"],"text":"◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion","text_display":"◯ \\(0=\\) Absent\n◯ 1 = Present in one limb\n◯ 2 = Present in two limbs\n◯ UN = amputation or joint fusion","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.76318359375,"confidence_rate":0.9952197084479893},{"cnt":[[1104,1624],[1138,1624],[1138,1659],[1104,1659]],"region":{"top_left_x":1103,"top_left_y":1623,"width":35,"height":36},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ab80c04f7fd94ccf90dfa1ef3b62ae06","type":"form_field","conversion_output":false,"parent_id":"134c2a18981942229f5f67f89fabc1b5","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1138,1634],[1242,1634],[1242,1660],[1138,1660]],"region":{"top_left_x":1137,"top_left_y":1634,"width":105,"height":27},"line":85,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"942da48391704d919b91a3c5ca84a460","type":"text","conversion_output":false,"parent_id":"134c2a18981942229f5f67f89fabc1b5","text":"\\(0=\\) Absent","text_display":" \\(0=\\) Absent","confidence":0.8664836220970074,"confidence_rate":0.9890365361951012},{"cnt":[[1105,1667],[1138,1667],[1138,1703],[1105,1703]],"region":{"top_left_x":1105,"top_left_y":1667,"width":33,"height":36},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"367f1eb0885249caa4170e6d494a12c7","type":"form_field","conversion_output":false,"parent_id":"134c2a18981942229f5f67f89fabc1b5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,1678],[1349,1678],[1349,1704],[1138,1704]],"region":{"top_left_x":1137,"top_left_y":1678,"width":213,"height":27},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b2f2cbddcd68438dbff22ad099e6474f","type":"text","conversion_output":false,"parent_id":"134c2a18981942229f5f67f89fabc1b5","text":"1 = Present in one limb","text_display":" 1 = Present in one limb","confidence":0.9951171875,"confidence_rate":0.9998187285658474},{"cnt":[[1105,1714],[1138,1714],[1138,1749],[1105,1749]],"region":{"top_left_x":1105,"top_left_y":1713,"width":33,"height":37},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a88bfecd2e434a48b8cffc612718111f","type":"form_field","conversion_output":false,"parent_id":"134c2a18981942229f5f67f89fabc1b5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,1722],[1358,1722],[1358,1748],[1138,1748]],"region":{"top_left_x":1137,"top_left_y":1721,"width":221,"height":27},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ff742b93dc33411bb52bc8723041d9d6","type":"text","conversion_output":false,"parent_id":"134c2a18981942229f5f67f89fabc1b5","text":"2 = Present in two limbs","text_display":" 2 = Present in two limbs","confidence":0.9873520873952657,"confidence_rate":0.9995455112276855},{"cnt":[[1105,1754],[1138,1754],[1138,1790],[1105,1790]],"region":{"top_left_x":1105,"top_left_y":1754,"width":33,"height":36},"line":90,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b44e9d25693f45a7bd6a0e36ca0c690c","type":"form_field","conversion_output":false,"parent_id":"134c2a18981942229f5f67f89fabc1b5","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1138,1764],[1419,1764],[1419,1791],[1138,1791]],"region":{"top_left_x":1137,"top_left_y":1764,"width":282,"height":28},"line":91,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"45a40b94998b4179a7dde66c0b1c38cc","type":"text","conversion_output":false,"parent_id":"134c2a18981942229f5f67f89fabc1b5","text":"UN = amputation or joint fusion","text_display":" UN = amputation or joint fusion","confidence":0.76318359375,"confidence_rate":0.9925209787882422},{"cnt":[[486,1935],[519,1935],[519,1962],[486,1962]],"region":{"top_left_x":485,"top_left_y":1934,"width":34,"height":28},"line":92,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ee6e26bc78ed4312b7ef70974f2a9171","type":"simple_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"17","text_display":"17","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[595,1935],[1041,1935],[1041,1963],[595,1963]],"region":{"top_left_x":594,"top_left_y":1934,"width":448,"height":30},"line":93,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"68eae6192b1f45c4afeb6e209b558f2e","type":"simple_cell","conversion_output":false,"parent_id":"03bc40a47f6842f4b18e8a311b203795","text":"Explain if amputation or joint fusion (Limb Ataxia):","text_display":"Explain if amputation or joint fusion (Limb Ataxia):","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[460,2378],[853,2378],[853,2413],[460,2413]],"region":{"top_left_x":459,"top_left_y":2378,"width":394,"height":35},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92d8dbf3383a4da28b2247e6039c9236","type":"text","conversion_output":true,"text":"Alteplase-Genentech, Inc.","text_display":"\n\nAlteplase-Genentech, Inc.","confidence":0.9941489696502686,"confidence_rate":0.9998044119734548},{"cnt":[[460,2415],[896,2415],[896,2447],[460,2447]],"region":{"top_left_x":459,"top_left_y":2414,"width":437,"height":34},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b662d8d5909945fa996bc0f36f2934fb","type":"text","conversion_output":true,"text":"81/Protocol ML29093, Version 3","text_display":"\n81/Protocol ML29093, Version 3","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a73c9c28eae4468b85b781eedb7db62","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9917227962366724,"confidence_rate":0.9998721366363669},{"cnt":[[372,2608],[694,2608],[694,2643],[372,2643]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":35},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a1f2a004b6b4929a424d233abead74a","type":"page_info","conversion_output":false,"text":"626/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-291","page":291,"lines":[{"cnt":[[610,374],[1626,374],[1626,479],[610,479]],"region":{"top_left_x":610,"top_left_y":373,"width":1017,"height":107},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c09e72a3e4b7433a8ab3d2b48f22d10b","type":"section_header","conversion_output":false,"children_ids":["2c61734537c642c7b5d7ebefca678c97","3ce482684ccf4b1e902fabf1ba63372f"],"text":"","text_display":""},{"cnt":[[928,382],[1304,382],[1304,432],[928,432]],"region":{"top_left_x":928,"top_left_y":382,"width":377,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c61734537c642c7b5d7ebefca678c97","type":"text","conversion_output":true,"parent_id":"c09e72a3e4b7433a8ab3d2b48f22d10b","text":"Appendix 7 (cont.)","text_display":"\n\n\\section*{Appendix 7 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[614,425],[1618,425],[1618,473],[614,473]],"region":{"top_left_x":614,"top_left_y":425,"width":1004,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ce482684ccf4b1e902fabf1ba63372f","type":"text","conversion_output":true,"parent_id":"c09e72a3e4b7433a8ab3d2b48f22d10b","text":"National Institutes of Health Stroke Scale (NIHSS)","text_display":" National Institutes of Health Stroke Scale (NIHSS)}","confidence":0.9776389163453132,"confidence_rate":0.999588904826212},{"cnt":[[460,520],[1772,520],[1772,1981],[460,1981]],"region":{"top_left_x":459,"top_left_y":519,"width":1314,"height":1462},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6ade78fdaaf840af9456722ca1d56077","type":"table","conversion_output":true,"children_ids":["54327ff106664f84937b692c040109be","fc21fc0c1ef44bf58192ad973bdf30b4","50bcf16e70b24e17be274be4d2072949","b8ad024a16e04c9eb49064af86077880","b7d78d5826214290a28da51c57d4df78","46f59881e598456cbed3290f1fba9940","8fc3933b55d74fcfb075ab5f58eff4da","e62da4de3bcc455baa168dc275bb24d6","29b1011bed884b89bb3e3a426bdd93f9","8909025b7181423c81b50e1441f11fc6","44ecb7e81b384eb29571d21a9bf31ef3","dd53b61c7bf14dc2bd44455f20746534","5b1a247865c64a33873b9d18b710e4af","3b57b400fd144c1dbcbdafd4fd8c6d14","73a3ba5d9d65434da303148303da48a7","7e5c149763ad4230b3b56f53efc00e20","7758d7082820489a8647e1b12316d653","5570e8583f85414f897004f6d473668d","6a40cf9e3ff64d9aafa9aadbd6b5ccc7","a2cbf6409bbb4b4fb9acc219f342953f","91eee42caa9149cfa2e65ce3e4aa8023","658d2fcb50ad4f81992c165368f993e0","83d6bc50cd964a3bab071805386dac65","f2346a5977274cf9bda679fff227d08d","333403db8e614b15900fb3e55a7a932a","90532ea685df45a1a4ef3aa59c33049b","a9a43d21597b474db32320de0d004c1c","baa44819cce34860871ac9d836713059"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline 18 & \\begin{tabular}{l}\n(8) Sensory \\\\\nSensation or girmace to pin prica when tested, or w/tholrawal from noxious stmusus in the colunded or aphasic patient. Only sensory loss attributed to stroke is soored as abonornal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, 'severe or total,' should only be given when a severe or total loss of sensation can be clearly demonstrated. Stuporous and aphasic patlents willing therefore probably score 1 or 0 . The pattent with brain stem stroke who has bilateral loss of sensation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (ftem 13-3) are arbiltrarlily given a 2 on this them. Coma Score \"2\".\n\\end{tabular} & ◯ \\(0=\\) Normali, no sensory loss\n◯ \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side; or there is a loss of superficial pain with pinprick but patent is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg \\\\\n\\hline 19 & \\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of information about comprehension will be oblained during the preceding sections of the examination. The patient is asked to desortbe what is happening in the altached ploture, to name the tems on the altached naming steet, and to read from the attached list of sentences. Comprehension is judged from responses here as well as to all of the commands in the preceding general neurrogical exam. If visual loss Interferes with the tests, ask the patient to identily objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to witte. The pattent in coma (question 13-3) will arditranty score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a soore of 3 should be used only if the patient is mute and follows no one stap commands. Coma Score \"3\".\n\\end{tabular} & ◯ \\(0=\\) No aphasia, normal\n◯ \\(1=\\) Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2=Severe aphasia; all communication is through fragmentary expression; great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension \\\\\n\\hline 20 & \\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be nomal an adequate sample of speech must be obtained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the ciartly of articulation of spontaneous speech can be rated. Only if the patlent is intubated or has other physical bamer to producing speech, may the them be not scored, and the examiner must cleany write an explanation. Do not tell the partent why helche is being tested. Coma Score \"2\"\n\\end{tabular} & ◯ 0=Normal\n◯ 1=Mild to moderate; patient slurs at least some words and at worst, can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mute/ anarthric\n◯ Intubated or other physical barrier. \\\\\n\\hline 21 & Explain if intubated or other physical barrier (Dysarthria): & \\\\\n\\hline 22 & \\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumplent information to Idently neglect may be obtained during the prior testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the cutaneous stimuli are normal, the score is nomial. If the patient has aphasla but does appear to athend to both sides, the score is nomial. The presence of visual spattal neglect or anosagnosia may also be taken as evidence of abnormally. Since the aboormally is scored only if present, the them is never untestable. Coma Score \"2\".\n\\end{tabular} & ◯ 0=No abnomality\n◯ \\(1=\\) Visual, tactile, auditory, spatial, or personal inattention or extinction to bilateral simultaneous stimulation in one of the sensory modalities\n◯ 2=Profound hemi-inattention or hemi-inattention to more than one modality; does not recognize own hand or onents to only one side of space \\\\\n\\hline 23 & Not applicable & \\\\\n\\hline 24 & \\begin{tabular}{l}\nName of assessor: \\\\\nThe assessor must be a study team member who has completed NIHSS certification.\n\\end{tabular} & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline 18 & \\begin{tabular}{l}\n(8) Sensory \\\\\nSensation or girmace to pin prica when tested, or w/tholrawal from noxious stmusus in the colunded or aphasic patient. Only sensory loss attributed to stroke is soored as abonornal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, 'severe or total,' should only be given when a severe or total loss of sensation can be clearly demonstrated. Stuporous and aphasic patlents willing therefore probably score 1 or 0 . The pattent with brain stem stroke who has bilateral loss of sensation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (ftem 13-3) are arbiltrarlily given a 2 on this them. Coma Score \"2\".\n\\end{tabular} & ◯ \\(0=\\) Normali, no sensory loss\n◯ \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side; or there is a loss of superficial pain with pinprick but patent is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg \\\\\n\\hline 19 & \\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of information about comprehension will be oblained during the preceding sections of the examination. The patient is asked to desortbe what is happening in the altached ploture, to name the tems on the altached naming steet, and to read from the attached list of sentences. Comprehension is judged from responses here as well as to all of the commands in the preceding general neurrogical exam. If visual loss Interferes with the tests, ask the patient to identily objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to witte. The pattent in coma (question 13-3) will arditranty score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a soore of 3 should be used only if the patient is mute and follows no one stap commands. Coma Score \"3\".\n\\end{tabular} & ◯ \\(0=\\) No aphasia, normal\n◯ \\(1=\\) Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2=Severe aphasia; all communication is through fragmentary expression; great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension \\\\\n\\hline 20 & \\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be nomal an adequate sample of speech must be obtained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the ciartly of articulation of spontaneous speech can be rated. Only if the patlent is intubated or has other physical bamer to producing speech, may the them be not scored, and the examiner must cleany write an explanation. Do not tell the partent why helche is being tested. Coma Score \"2\"\n\\end{tabular} & ◯ 0=Normal\n◯ 1=Mild to moderate; patient slurs at least some words and at worst, can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mute/ anarthric\n◯ Intubated or other physical barrier. \\\\\n\\hline 21 & Explain if intubated or other physical barrier (Dysarthria): & \\\\\n\\hline 22 & \\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumplent information to Idently neglect may be obtained during the prior testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the cutaneous stimuli are normal, the score is nomial. If the patient has aphasla but does appear to athend to both sides, the score is nomial. The presence of visual spattal neglect or anosagnosia may also be taken as evidence of abnormally. Since the aboormally is scored only if present, the them is never untestable. Coma Score \"2\".\n\\end{tabular} & ◯ 0=No abnomality\n◯ \\(1=\\) Visual, tactile, auditory, spatial, or personal inattention or extinction to bilateral simultaneous stimulation in one of the sensory modalities\n◯ 2=Profound hemi-inattention or hemi-inattention to more than one modality; does not recognize own hand or onents to only one side of space \\\\\n\\hline 23 & Not applicable & \\\\\n\\hline 24 & \\begin{tabular}{l}\nName of assessor: \\\\\nThe assessor must be a study team member who has completed NIHSS certification.\n\\end{tabular} & \\\\\n\\hline\n\\end{tabular}","confidence":0.041128479356387984,"confidence_rate":0.9965463185832322},{"cnt":[[484,522],[518,522],[518,1980],[484,1980]],"region":{"top_left_x":483,"top_left_y":521,"width":35,"height":1460},"line":5,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"54327ff106664f84937b692c040109be","type":"table_column","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[535,1980],[537,521],[1123,522],[1121,1981]],"region":{"top_left_x":535,"top_left_y":521,"width":588,"height":1460},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fc21fc0c1ef44bf58192ad973bdf30b4","type":"table_column","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[1127,519],[1760,519],[1760,1980],[1127,1980]],"region":{"top_left_x":1127,"top_left_y":519,"width":634,"height":1462},"line":7,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"50bcf16e70b24e17be274be4d2072949","type":"table_column","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[459,539],[1771,539],[1771,795],[459,795]],"region":{"top_left_x":459,"top_left_y":539,"width":1313,"height":256},"line":8,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b8ad024a16e04c9eb49064af86077880","type":"table_row","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[459,808],[1771,808],[1771,1107],[459,1107]],"region":{"top_left_x":459,"top_left_y":808,"width":1313,"height":299},"line":9,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b7d78d5826214290a28da51c57d4df78","type":"table_row","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[459,1125],[1771,1125],[1771,1363],[459,1363]],"region":{"top_left_x":459,"top_left_y":1124,"width":1313,"height":240},"line":10,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"46f59881e598456cbed3290f1fba9940","type":"table_row","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[460,1389],[1771,1389],[1771,1423],[460,1423]],"region":{"top_left_x":460,"top_left_y":1389,"width":1312,"height":35},"line":11,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8fc3933b55d74fcfb075ab5f58eff4da","type":"table_row","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[459,1460],[1771,1460],[1771,1683],[459,1683]],"region":{"top_left_x":459,"top_left_y":1460,"width":1313,"height":223},"line":12,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e62da4de3bcc455baa168dc275bb24d6","type":"table_row","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[459,1711],[1773,1711],[1773,1803],[459,1803]],"region":{"top_left_x":459,"top_left_y":1711,"width":1314,"height":92},"line":13,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"29b1011bed884b89bb3e3a426bdd93f9","type":"table_row","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[459,1875],[1771,1875],[1771,1969],[459,1969]],"region":{"top_left_x":459,"top_left_y":1874,"width":1313,"height":96},"line":14,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8909025b7181423c81b50e1441f11fc6","type":"table_row","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"","text_display":""},{"cnt":[[481,651],[516,651],[516,680],[481,680]],"region":{"top_left_x":480,"top_left_y":651,"width":37,"height":29},"line":15,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"44ecb7e81b384eb29571d21a9bf31ef3","type":"simple_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"18","text_display":"18","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9997558295653994},{"cnt":[[541,546],[1118,546],[1118,793],[541,793]],"region":{"top_left_x":540,"top_left_y":546,"width":578,"height":248},"line":16,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"dd53b61c7bf14dc2bd44455f20746534","type":"complex_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","children_ids":["6964e107e4b7458dbfdc6738e9241442","1a445908b75848e18cdaed4dcdb8de4d","e4b1787f4f5d458c8096e91142a58ac8","4c344753f2f54b2c91aa97e3b23e5e32","21fa9e26bfe345609cd484038ca4848b","854357f7fe4b49b3996231bc55d152d0","645be9dba38943d28b4f7a48a506160a","d7fa61db0ea94095bc7563e9cee26e30","6c98009b3e4c49ff848790c96507c06e","2b0230a7fb82441f8b535ede3a249ffc","e58cfb581ca84b9283c1380ab6143be8"],"text":"\\begin{tabular}{l}\n(8) Sensory \\\\\nSensation or girmace to pin prica when tested, or w/tholrawal from noxious stmusus in the colunded or aphasic patient. Only sensory loss attributed to stroke is soored as abonornal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, 'severe or total,' should only be given when a severe or total loss of sensation can be clearly demonstrated. Stuporous and aphasic patlents willing therefore probably score 1 or 0 . The pattent with brain stem stroke who has bilateral loss of sensation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (ftem 13-3) are arbiltrarlily given a 2 on this them. Coma Score \"2\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(8) Sensory \\\\\nSensation or girmace to pin prica when tested, or w/tholrawal from noxious stmusus in the colunded or aphasic patient. Only sensory loss attributed to stroke is soored as abonornal and the examiner should test as many body areas [arms (not hands), legs, trunk, face] as needed to accurately check for hemisensory loss. A score of 2, 'severe or total,' should only be given when a severe or total loss of sensation can be clearly demonstrated. Stuporous and aphasic patlents willing therefore probably score 1 or 0 . The pattent with brain stem stroke who has bilateral loss of sensation is scored 2. If the patent does not respond and is quadriplegic score 2. Patients in coma (ftem 13-3) are arbiltrarlily given a 2 on this them. Coma Score \"2\".\n\\end{tabular}","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.041128479356387984,"confidence_rate":0.9862220373624551},{"cnt":[[775,549],[886,549],[886,576],[775,576]],"region":{"top_left_x":775,"top_left_y":549,"width":111,"height":28},"line":17,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6964e107e4b7458dbfdc6738e9241442","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"(8) Sensory","text_display":"(8) Sensory","confidence":1,"confidence_rate":1},{"cnt":[[548,587],[1112,587],[1112,610],[548,610]],"region":{"top_left_x":547,"top_left_y":587,"width":566,"height":24},"line":18,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"1a445908b75848e18cdaed4dcdb8de4d","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"Sensation or girmace to pin prica when tested, or w/tholrawal from noxious","text_display":"\nSensation or girmace to pin prica when tested, or w/tholrawal from noxious","confidence":0.15939922687800945,"confidence_rate":0.9770232277136665},{"cnt":[[544,609],[1115,609],[1115,631],[544,631]],"region":{"top_left_x":543,"top_left_y":609,"width":573,"height":22},"line":19,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e4b1787f4f5d458c8096e91142a58ac8","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"stmusus in the colunded or aphasic patient. Only sensory loss attributed to","text_display":" stmusus in the colunded or aphasic patient. Only sensory loss attributed to","confidence":0.3297885242063541,"confidence_rate":0.9862293984399263},{"cnt":[[550,628],[1110,628],[1110,651],[550,651]],"region":{"top_left_x":550,"top_left_y":628,"width":560,"height":24},"line":20,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4c344753f2f54b2c91aa97e3b23e5e32","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"stroke is soored as abonornal and the examiner should test as many body","text_display":" stroke is soored as abonornal and the examiner should test as many body","confidence":0.30863456947149703,"confidence_rate":0.9846506351473184},{"cnt":[[552,650],[1107,650],[1107,670],[552,670]],"region":{"top_left_x":551,"top_left_y":649,"width":556,"height":22},"line":21,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"21fa9e26bfe345609cd484038ca4848b","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"areas [arms (not hands), legs, trunk, face] as needed to accurately check","text_display":" areas [arms (not hands), legs, trunk, face] as needed to accurately check","confidence":0.6061309080014226,"confidence_rate":0.9936018469791594},{"cnt":[[550,669],[1108,669],[1108,690],[550,690]],"region":{"top_left_x":550,"top_left_y":669,"width":559,"height":21},"line":22,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"854357f7fe4b49b3996231bc55d152d0","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"for hemisensory loss. A score of 2, 'severe or total,' should only be given","text_display":" for hemisensory loss. A score of 2, 'severe or total,' should only be given","confidence":0.5619148864885872,"confidence_rate":0.9928208331244999},{"cnt":[[565,688],[1093,688],[1093,709],[565,709]],"region":{"top_left_x":565,"top_left_y":688,"width":529,"height":21},"line":23,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"645be9dba38943d28b4f7a48a506160a","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"when a severe or total loss of sensation can be clearly demonstrated.","text_display":" when a severe or total loss of sensation can be clearly demonstrated.","confidence":0.7301337182270015,"confidence_rate":0.9957586472670924},{"cnt":[[554,707],[1107,707],[1107,730],[554,730]],"region":{"top_left_x":554,"top_left_y":707,"width":553,"height":24},"line":24,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d7fa61db0ea94095bc7563e9cee26e30","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"Stuporous and aphasic patlents willing therefore probably score 1 or 0 . The","text_display":" Stuporous and aphasic patlents willing therefore probably score 1 or 0 . The","confidence":0.04411989578573941,"confidence_rate":0.9647639921750009},{"cnt":[[548,729],[1112,729],[1112,750],[548,750]],"region":{"top_left_x":547,"top_left_y":729,"width":566,"height":21},"line":25,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6c98009b3e4c49ff848790c96507c06e","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"pattent with brain stem stroke who has bilateral loss of sensation is scored","text_display":" pattent with brain stem stroke who has bilateral loss of sensation is scored","confidence":0.9085815197315457,"confidence_rate":0.9988171117060113},{"cnt":[[552,748],[1107,748],[1107,769],[552,769]],"region":{"top_left_x":551,"top_left_y":748,"width":556,"height":21},"line":26,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2b0230a7fb82441f8b535ede3a249ffc","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"2. If the patent does not respond and is quadriplegic score 2. Patients in","text_display":" 2. If the patent does not respond and is quadriplegic score 2. Patients in","confidence":0.6133777003293324,"confidence_rate":0.9938320826855712},{"cnt":[[552,767],[1107,767],[1107,790],[552,790]],"region":{"top_left_x":551,"top_left_y":767,"width":556,"height":24},"line":27,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e58cfb581ca84b9283c1380ab6143be8","type":"text","conversion_output":false,"parent_id":"dd53b61c7bf14dc2bd44455f20746534","text":"coma (ftem 13-3) are arbiltrarlily given a 2 on this them. Coma Score \"2\".","text_display":" coma (ftem 13-3) are arbiltrarlily given a 2 on this them. Coma Score \"2\".","confidence":0.041128479356387984,"confidence_rate":0.9618321744171985},{"cnt":[[1130,574],[1760,574],[1760,771],[1130,771]],"region":{"top_left_x":1130,"top_left_y":573,"width":631,"height":199},"line":28,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5b1a247865c64a33873b9d18b710e4af","type":"complex_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","children_ids":["edb533fc9bdf4f6894d69c81f1df2fe1","c6e04b12e7ff42c298bf848cb6e0b4bc","a878079b91ae4823894755a77aee6d7f","c94fcaa70a7940c4b3835648e2da621a","240a374e98694d5989eec9fcceb4632b","4937d07a34ca4495acd31f3a95850184","a2b2f43e41de42838498f0717e8dd53f","12981be1345b4cb0a034b526cee3fbd6","ff1627dd53e246d2b91a6650b056e500"],"text":"◯ \\(0=\\) Normali, no sensory loss\n◯ \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side; or there is a loss of superficial pain with pinprick but patent is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg","text_display":"◯ \\(0=\\) Normali, no sensory loss\n◯ \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp or is dull on the affected side; or there is a loss of superficial pain with pinprick but patent is aware he/she is being touched\n◯ 2=Severe to total sensory loss; patient is not aware of being touched in the face, arm \\& leg","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.515784698412971,"confidence_rate":0.9928158382770843},{"cnt":[[1133,576],[1166,576],[1166,610],[1133,610]],"region":{"top_left_x":1132,"top_left_y":576,"width":34,"height":35},"line":29,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"edb533fc9bdf4f6894d69c81f1df2fe1","type":"form_field","conversion_output":false,"parent_id":"5b1a247865c64a33873b9d18b710e4af","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1166,587],[1402,587],[1402,613],[1166,613]],"region":{"top_left_x":1165,"top_left_y":587,"width":237,"height":27},"line":30,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c6e04b12e7ff42c298bf848cb6e0b4bc","type":"text","conversion_output":false,"parent_id":"5b1a247865c64a33873b9d18b710e4af","text":"\\(0=\\) Normali, no sensory loss","text_display":" \\(0=\\) Normali, no sensory loss","confidence":0.515784698412971,"confidence_rate":0.9788694820507722},{"cnt":[[1133,620],[1164,620],[1164,653],[1133,653]],"region":{"top_left_x":1132,"top_left_y":619,"width":33,"height":34},"line":31,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a878079b91ae4823894755a77aee6d7f","type":"form_field","conversion_output":false,"parent_id":"5b1a247865c64a33873b9d18b710e4af","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1168,631],[1755,631],[1755,654],[1168,654]],"region":{"top_left_x":1168,"top_left_y":630,"width":587,"height":25},"line":32,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c94fcaa70a7940c4b3835648e2da621a","type":"text","conversion_output":false,"parent_id":"5b1a247865c64a33873b9d18b710e4af","text":"\\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp","text_display":" \\(1=\\) Mild to moderate sensory loss; patient feels pinprick is less sharp","confidence":0.9378817214662147,"confidence_rate":0.9991337344188473},{"cnt":[[1185,655],[1751,655],[1751,681],[1185,681]],"region":{"top_left_x":1184,"top_left_y":655,"width":567,"height":27},"line":33,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"240a374e98694d5989eec9fcceb4632b","type":"text","conversion_output":false,"parent_id":"5b1a247865c64a33873b9d18b710e4af","text":"or is dull on the affected side; or there is a loss of superficial pain","text_display":" or is dull on the affected side; or there is a loss of superficial pain","confidence":0.9406721591949463,"confidence_rate":0.9991955790322624},{"cnt":[[1185,680],[1684,680],[1684,706],[1185,706]],"region":{"top_left_x":1184,"top_left_y":679,"width":501,"height":27},"line":34,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4937d07a34ca4495acd31f3a95850184","type":"text","conversion_output":false,"parent_id":"5b1a247865c64a33873b9d18b710e4af","text":"with pinprick but patent is aware he/she is being touched","text_display":" with pinprick but patent is aware he/she is being touched","confidence":0.6814756393432617,"confidence_rate":0.9938336906208151},{"cnt":[[1132,707],[1164,707],[1164,740],[1132,740]],"region":{"top_left_x":1131,"top_left_y":707,"width":34,"height":33},"line":35,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a2b2f43e41de42838498f0717e8dd53f","type":"form_field","conversion_output":false,"parent_id":"5b1a247865c64a33873b9d18b710e4af","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1166,718],[1688,718],[1688,741],[1166,741]],"region":{"top_left_x":1165,"top_left_y":718,"width":524,"height":24},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"12981be1345b4cb0a034b526cee3fbd6","type":"text","conversion_output":false,"parent_id":"5b1a247865c64a33873b9d18b710e4af","text":"2=Severe to total sensory loss; patient is not aware of being","text_display":" 2=Severe to total sensory loss; patient is not aware of being","confidence":0.99951171875,"confidence_rate":0.9999926000198329},{"cnt":[[1185,743],[1449,743],[1449,769],[1185,769]],"region":{"top_left_x":1184,"top_left_y":742,"width":266,"height":27},"line":37,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ff1627dd53e246d2b91a6650b056e500","type":"text","conversion_output":false,"parent_id":"5b1a247865c64a33873b9d18b710e4af","text":"touched in the face, arm \\& leg","text_display":" touched in the face, arm \\& leg","confidence":0.6117820739746094,"confidence_rate":0.9860586886108395},{"cnt":[[481,947],[516,947],[516,972],[481,972]],"region":{"top_left_x":480,"top_left_y":947,"width":37,"height":25},"line":38,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3b57b400fd144c1dbcbdafd4fd8c6d14","type":"simple_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"19","text_display":"19","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[538,810],[1122,810],[1122,1093],[538,1093]],"region":{"top_left_x":538,"top_left_y":809,"width":584,"height":285},"line":39,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"73a3ba5d9d65434da303148303da48a7","type":"complex_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","children_ids":["300fa5190ecb4c3ea37c48e20dc25756","5104adbc748b40f5a15bf6bd55cb2108","3e8970b5ad4441f4b335f221e360418c","94b8a3dbef394c51bdac30e9ad2d06df","ca1d5601bddb4fc59ea83c043506ae7d","748af76033a14f8a9f1a6a529f453989","2cb3ac07045f4f4b91b9bf5db03064fe","2751df81c9ff4cc98149e054ba5a5b31","0cdc559f285341499c2dd78077fc35d6","5c315c9142b24ef39c8531f6ec088161","99c321c657b040f0b6871869e3d68029","c422eb75b38c43f7abe379fe8d7540bc","8046c18d8c7b4502bcfd0719b06200f5"],"text":"\\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of information about comprehension will be oblained during the preceding sections of the examination. The patient is asked to desortbe what is happening in the altached ploture, to name the tems on the altached naming steet, and to read from the attached list of sentences. Comprehension is judged from responses here as well as to all of the commands in the preceding general neurrogical exam. If visual loss Interferes with the tests, ask the patient to identily objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to witte. The pattent in coma (question 13-3) will arditranty score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a soore of 3 should be used only if the patient is mute and follows no one stap commands. Coma Score \"3\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(9) Best Language \\\\\nA great deal of information about comprehension will be oblained during the preceding sections of the examination. The patient is asked to desortbe what is happening in the altached ploture, to name the tems on the altached naming steet, and to read from the attached list of sentences. Comprehension is judged from responses here as well as to all of the commands in the preceding general neurrogical exam. If visual loss Interferes with the tests, ask the patient to identily objects placed in the hand, repeat, and produce speech. The intubated patent should be asked to witte. The pattent in coma (question 13-3) will arditranty score 3 on this Item. The examiner must choose a score in the patient with stupor or limited cooperation but a soore of 3 should be used only if the patient is mute and follows no one stap commands. Coma Score \"3\".\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.20930191743127277,"confidence_rate":0.991678452366503},{"cnt":[[740,811],[919,811],[919,837],[740,837]],"region":{"top_left_x":740,"top_left_y":810,"width":179,"height":27},"line":40,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"300fa5190ecb4c3ea37c48e20dc25756","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"(9) Best Language","text_display":"(9) Best Language","confidence":1,"confidence_rate":1},{"cnt":[[541,849],[1118,849],[1118,872],[541,872]],"region":{"top_left_x":540,"top_left_y":849,"width":578,"height":24},"line":41,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5104adbc748b40f5a15bf6bd55cb2108","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"A great deal of information about comprehension will be oblained during the","text_display":"\nA great deal of information about comprehension will be oblained during the","confidence":0.21886040813337765,"confidence_rate":0.9811876880979463},{"cnt":[[557,871],[1102,871],[1102,894],[557,894]],"region":{"top_left_x":557,"top_left_y":870,"width":545,"height":25},"line":42,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3e8970b5ad4441f4b335f221e360418c","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"preceding sections of the examination. The patient is asked to desortbe","text_display":" preceding sections of the examination. The patient is asked to desortbe","confidence":0.6546640737738585,"confidence_rate":0.9944413876366281},{"cnt":[[574,890],[1085,890],[1085,913],[574,913]],"region":{"top_left_x":573,"top_left_y":890,"width":513,"height":24},"line":43,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"94b8a3dbef394c51bdac30e9ad2d06df","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"what is happening in the altached ploture, to name the tems on the","text_display":" what is happening in the altached ploture, to name the tems on the","confidence":0.355374588249036,"confidence_rate":0.9855340621335825},{"cnt":[[557,909],[1102,909],[1102,932],[557,932]],"region":{"top_left_x":557,"top_left_y":909,"width":545,"height":24},"line":44,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ca1d5601bddb4fc59ea83c043506ae7d","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"altached naming steet, and to read from the attached list of sentences.","text_display":" altached naming steet, and to read from the attached list of sentences.","confidence":0.8721295182661493,"confidence_rate":0.9982013913336707},{"cnt":[[565,928],[1093,928],[1093,951],[565,951]],"region":{"top_left_x":565,"top_left_y":928,"width":529,"height":24},"line":45,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"748af76033a14f8a9f1a6a529f453989","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"Comprehension is judged from responses here as well as to all of the","text_display":" Comprehension is judged from responses here as well as to all of the","confidence":0.4143492259672188,"confidence_rate":0.9880034148363608},{"cnt":[[568,950],[1093,950],[1093,971],[568,971]],"region":{"top_left_x":568,"top_left_y":950,"width":526,"height":21},"line":46,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2cb3ac07045f4f4b91b9bf5db03064fe","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"commands in the preceding general neurrogical exam. If visual loss","text_display":" commands in the preceding general neurrogical exam. If visual loss","confidence":0.526371459169697,"confidence_rate":0.9910020203992492},{"cnt":[[560,969],[1100,969],[1100,992],[560,992]],"region":{"top_left_x":559,"top_left_y":969,"width":542,"height":24},"line":47,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"2751df81c9ff4cc98149e054ba5a5b31","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"Interferes with the tests, ask the patient to identily objects placed in the","text_display":" Interferes with the tests, ask the patient to identily objects placed in the","confidence":0.5553081209356108,"confidence_rate":0.9927641802506091},{"cnt":[[546,988],[1112,988],[1112,1011],[546,1011]],"region":{"top_left_x":546,"top_left_y":988,"width":567,"height":24},"line":48,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0cdc559f285341499c2dd78077fc35d6","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"hand, repeat, and produce speech. The intubated patent should be asked","text_display":" hand, repeat, and produce speech. The intubated patent should be asked","confidence":0.926229719652838,"confidence_rate":0.9989787485296189},{"cnt":[[548,1007],[1112,1007],[1112,1031],[548,1031]],"region":{"top_left_x":547,"top_left_y":1007,"width":566,"height":24},"line":49,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5c315c9142b24ef39c8531f6ec088161","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"to witte. The pattent in coma (question 13-3) will arditranty score 3 on this","text_display":" to witte. The pattent in coma (question 13-3) will arditranty score 3 on this","confidence":0.20930191743127277,"confidence_rate":0.9817685065214979},{"cnt":[[541,1026],[1119,1026],[1119,1050],[541,1050]],"region":{"top_left_x":540,"top_left_y":1026,"width":580,"height":24},"line":50,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"99c321c657b040f0b6871869e3d68029","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"Item. The examiner must choose a score in the patient with stupor or limited","text_display":" Item. The examiner must choose a score in the patient with stupor or limited","confidence":0.891428005500809,"confidence_rate":0.9985821098422694},{"cnt":[[548,1048],[1115,1048],[1115,1071],[548,1071]],"region":{"top_left_x":547,"top_left_y":1048,"width":569,"height":24},"line":51,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c422eb75b38c43f7abe379fe8d7540bc","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"cooperation but a soore of 3 should be used only if the patient is mute and","text_display":" cooperation but a soore of 3 should be used only if the patient is mute and","confidence":0.8498127395629833,"confidence_rate":0.9980412069660776},{"cnt":[[636,1067],[1022,1067],[1022,1091],[636,1091]],"region":{"top_left_x":636,"top_left_y":1067,"width":387,"height":24},"line":52,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"8046c18d8c7b4502bcfd0719b06200f5","type":"text","conversion_output":false,"parent_id":"73a3ba5d9d65434da303148303da48a7","text":"follows no one stap commands. Coma Score \"3\".","text_display":" follows no one stap commands. Coma Score \"3\".","confidence":0.43770463376920776,"confidence_rate":0.9836115570491408},{"cnt":[[1129,822],[1759,822],[1759,1106],[1129,1106]],"region":{"top_left_x":1128,"top_left_y":821,"width":632,"height":285},"line":53,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7e5c149763ad4230b3b56f53efc00e20","type":"complex_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","children_ids":["0da1eab216bc4081be7854d2f9fbac1d","d2ed2d8c31ec4abca5341a327d035632","5153c65ce07f4e968568d92bfafcd29c","a750703d33044ec49d2ce3d59eb2f826","c894b9a549c643c685119b802c03f390","755908e67f604217944435e596f5ee58","5bb7dae5be7f4092b9be7e20fc58b7be","548df272f268406dbbce08369e455f3e","bf6a116499744cdeac85de2132ecc564","fd3bdea1778c43a891b678693ef91aa2","cb49d3e064b145f68a724dab7dcac299","48485db2097a486bab1735ca14e72dd7","ee8abbbdac40420f933c3947ae5156df"],"text":"◯ \\(0=\\) No aphasia, normal\n◯ \\(1=\\) Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2=Severe aphasia; all communication is through fragmentary expression; great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension","text_display":"◯ \\(0=\\) No aphasia, normal\n◯ \\(1=\\) Mild to moderate aphasia; some obvious loss of fluency or facility of comprehension without significant limitation on ideas expressed on form of expression\n◯ 2=Severe aphasia; all communication is through fragmentary expression; great need for inference, questioning, and guessing by the listener; listener carries burden of communication\n◯ 3=Mute, global aphasia; no usable speech or auditory comprehension","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.5304969035233658,"confidence_rate":0.9959870350163081},{"cnt":[[1130,826],[1166,826],[1166,860],[1130,860]],"region":{"top_left_x":1130,"top_left_y":825,"width":36,"height":36},"line":54,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0da1eab216bc4081be7854d2f9fbac1d","type":"form_field","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1166,837],[1362,837],[1362,861],[1166,861]],"region":{"top_left_x":1165,"top_left_y":836,"width":198,"height":26},"line":55,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d2ed2d8c31ec4abca5341a327d035632","type":"text","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"\\(0=\\) No aphasia, normal","text_display":" \\(0=\\) No aphasia, normal","confidence":0.5304969035233658,"confidence_rate":0.9749611584023327},{"cnt":[[1130,865],[1166,865],[1166,898],[1130,898]],"region":{"top_left_x":1130,"top_left_y":865,"width":36,"height":34},"line":56,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5153c65ce07f4e968568d92bfafcd29c","type":"form_field","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1166,876],[1756,876],[1756,902],[1166,902]],"region":{"top_left_x":1165,"top_left_y":876,"width":592,"height":27},"line":57,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a750703d33044ec49d2ce3d59eb2f826","type":"text","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"\\(1=\\) Mild to moderate aphasia; some obvious loss of fluency or facility","text_display":" \\(1=\\) Mild to moderate aphasia; some obvious loss of fluency or facility","confidence":0.9326681330333031,"confidence_rate":0.9990455812243736},{"cnt":[[1185,904],[1666,904],[1666,928],[1185,928]],"region":{"top_left_x":1184,"top_left_y":903,"width":483,"height":26},"line":58,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c894b9a549c643c685119b802c03f390","type":"text","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"of comprehension without significant limitation on ideas","text_display":" of comprehension without significant limitation on ideas","confidence":1,"confidence_rate":1},{"cnt":[[1185,927],[1475,927],[1475,951],[1185,951]],"region":{"top_left_x":1184,"top_left_y":926,"width":292,"height":26},"line":59,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"755908e67f604217944435e596f5ee58","type":"text","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"expressed on form of expression","text_display":" expressed on form of expression","confidence":1,"confidence_rate":1},{"cnt":[[1133,956],[1164,956],[1164,988],[1133,988]],"region":{"top_left_x":1132,"top_left_y":955,"width":33,"height":34},"line":60,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5bb7dae5be7f4092b9be7e20fc58b7be","type":"form_field","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1166,964],[1696,964],[1696,990],[1166,990]],"region":{"top_left_x":1165,"top_left_y":963,"width":532,"height":27},"line":61,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"548df272f268406dbbce08369e455f3e","type":"text","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"2=Severe aphasia; all communication is through fragmentary","text_display":" 2=Severe aphasia; all communication is through fragmentary","confidence":0.97021484375,"confidence_rate":0.9995201509801361},{"cnt":[[1185,991],[1740,991],[1740,1017],[1185,1017]],"region":{"top_left_x":1184,"top_left_y":991,"width":556,"height":26},"line":62,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bf6a116499744cdeac85de2132ecc564","type":"text","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"expression; great need for inference, questioning, and guessing","text_display":" expression; great need for inference, questioning, and guessing","confidence":0.99853515625,"confidence_rate":0.9999784426193857},{"cnt":[[1185,1016],[1674,1016],[1674,1039],[1185,1039]],"region":{"top_left_x":1184,"top_left_y":1015,"width":491,"height":24},"line":63,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"fd3bdea1778c43a891b678693ef91aa2","type":"text","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"by the listener; listener carries burden of communication","text_display":" by the listener; listener carries burden of communication","confidence":0.5609750747680664,"confidence_rate":0.9907194806411408},{"cnt":[[1132,1043],[1163,1043],[1163,1074],[1132,1074]],"region":{"top_left_x":1131,"top_left_y":1042,"width":32,"height":33},"line":64,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"cb49d3e064b145f68a724dab7dcac299","type":"form_field","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1166,1051],[1636,1051],[1636,1080],[1166,1080]],"region":{"top_left_x":1165,"top_left_y":1051,"width":472,"height":29},"line":65,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"48485db2097a486bab1735ca14e72dd7","type":"text","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"3=Mute, global aphasia; no usable speech or auditory","text_display":" 3=Mute, global aphasia; no usable speech or auditory","confidence":0.9970715045928955,"confidence_rate":0.9999485488352375},{"cnt":[[1185,1078],[1323,1078],[1323,1104],[1185,1104]],"region":{"top_left_x":1184,"top_left_y":1078,"width":139,"height":27},"line":66,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ee8abbbdac40420f933c3947ae5156df","type":"text","conversion_output":false,"parent_id":"7e5c149763ad4230b3b56f53efc00e20","text":"comprehension","text_display":" comprehension","confidence":1,"confidence_rate":1},{"cnt":[[481,1230],[516,1230],[516,1254],[481,1254]],"region":{"top_left_x":480,"top_left_y":1229,"width":37,"height":26},"line":67,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7758d7082820489a8647e1b12316d653","type":"simple_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"20","text_display":"20","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[538,1134],[1122,1134],[1122,1339],[538,1339]],"region":{"top_left_x":538,"top_left_y":1134,"width":584,"height":205},"line":68,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"5570e8583f85414f897004f6d473668d","type":"complex_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","children_ids":["7042eff06e2c418b804d0b19765efeee","b3d8ebb7e37e473a8b619563689398b2","09d95b2d5a3a466d814f2703385a8620","0954e04c91984401881d30e5dd1beb47","0b697236ffc940f296ddbeca8d70c507","b7f08c47d8f94fc8b5f14cb8d11e08da","68e600ed238d4465b3159d5612eff1eb","b33e744340e9457e947f59890727379a"],"text":"\\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be nomal an adequate sample of speech must be obtained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the ciartly of articulation of spontaneous speech can be rated. Only if the patlent is intubated or has other physical bamer to producing speech, may the them be not scored, and the examiner must cleany write an explanation. Do not tell the partent why helche is being tested. Coma Score \"2\"\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(10) Dysarthria \\\\\nIf patient is thought to be nomal an adequate sample of speech must be obtained by asking patient to read or repeat words from the attached list. If the patient has severe aphasia, the ciartly of articulation of spontaneous speech can be rated. Only if the patlent is intubated or has other physical bamer to producing speech, may the them be not scored, and the examiner must cleany write an explanation. Do not tell the partent why helche is being tested. Coma Score \"2\"\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.1250416394415256,"confidence_rate":0.9892730149518134},{"cnt":[[762,1147],[900,1147],[900,1175],[762,1175]],"region":{"top_left_x":761,"top_left_y":1146,"width":139,"height":30},"line":69,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"7042eff06e2c418b804d0b19765efeee","type":"text","conversion_output":false,"parent_id":"5570e8583f85414f897004f6d473668d","text":"(10) Dysarthria","text_display":"(10) Dysarthria","confidence":1,"confidence_rate":1},{"cnt":[[552,1196],[1107,1196],[1107,1219],[552,1219]],"region":{"top_left_x":551,"top_left_y":1195,"width":556,"height":24},"line":70,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b3d8ebb7e37e473a8b619563689398b2","type":"text","conversion_output":false,"parent_id":"5570e8583f85414f897004f6d473668d","text":"If patient is thought to be nomal an adequate sample of speech must be","text_display":"\nIf patient is thought to be nomal an adequate sample of speech must be","confidence":0.3202191828913505,"confidence_rate":0.9849313579340195},{"cnt":[[546,1215],[1115,1215],[1115,1237],[546,1237]],"region":{"top_left_x":546,"top_left_y":1214,"width":570,"height":23},"line":71,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"09d95b2d5a3a466d814f2703385a8620","type":"text","conversion_output":false,"parent_id":"5570e8583f85414f897004f6d473668d","text":"obtained by asking patient to read or repeat words from the attached list. If","text_display":" obtained by asking patient to read or repeat words from the attached list. If","confidence":0.9496115515224421,"confidence_rate":0.9993696832314041},{"cnt":[[554,1234],[1104,1234],[1104,1257],[554,1257]],"region":{"top_left_x":554,"top_left_y":1233,"width":551,"height":25},"line":72,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0954e04c91984401881d30e5dd1beb47","type":"text","conversion_output":false,"parent_id":"5570e8583f85414f897004f6d473668d","text":"the patient has severe aphasia, the ciartly of articulation of spontaneous","text_display":" the patient has severe aphasia, the ciartly of articulation of spontaneous","confidence":0.19974896469424688,"confidence_rate":0.9798179105986116},{"cnt":[[552,1253],[1107,1253],[1107,1276],[552,1276]],"region":{"top_left_x":551,"top_left_y":1252,"width":556,"height":25},"line":73,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0b697236ffc940f296ddbeca8d70c507","type":"text","conversion_output":false,"parent_id":"5570e8583f85414f897004f6d473668d","text":"speech can be rated. Only if the patlent is intubated or has other physical","text_display":" speech can be rated. Only if the patlent is intubated or has other physical","confidence":0.571737262205313,"confidence_rate":0.9930359158461376},{"cnt":[[541,1273],[1118,1273],[1118,1295],[541,1295]],"region":{"top_left_x":540,"top_left_y":1273,"width":578,"height":23},"line":74,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b7f08c47d8f94fc8b5f14cb8d11e08da","type":"text","conversion_output":false,"parent_id":"5570e8583f85414f897004f6d473668d","text":"bamer to producing speech, may the them be not scored, and the examiner","text_display":" bamer to producing speech, may the them be not scored, and the examiner","confidence":0.26487617601766567,"confidence_rate":0.9826717231126887},{"cnt":[[541,1294],[1119,1294],[1119,1317],[541,1317]],"region":{"top_left_x":540,"top_left_y":1293,"width":580,"height":25},"line":75,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"68e600ed238d4465b3159d5612eff1eb","type":"text","conversion_output":false,"parent_id":"5570e8583f85414f897004f6d473668d","text":"must cleany write an explanation. Do not tell the partent why helche is being","text_display":" must cleany write an explanation. Do not tell the partent why helche is being","confidence":0.1250416394415256,"confidence_rate":0.9749637565122643},{"cnt":[[729,1313],[930,1313],[930,1333],[729,1333]],"region":{"top_left_x":729,"top_left_y":1312,"width":201,"height":22},"line":76,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b33e744340e9457e947f59890727379a","type":"text","conversion_output":false,"parent_id":"5570e8583f85414f897004f6d473668d","text":"tested. Coma Score \"2\"","text_display":" tested. Coma Score \"2\"","confidence":0.9931788295585287,"confidence_rate":0.9997465306117058},{"cnt":[[1130,1126],[1759,1126],[1759,1361],[1130,1361]],"region":{"top_left_x":1130,"top_left_y":1126,"width":630,"height":235},"line":77,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","type":"complex_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","children_ids":["4e4b7a4c5b5f43aea5c14200a9db91fd","26346ed68530409f98f9922eb7d6592e","b9538d2647674c79b9d69d009ec43dcf","da40ac0a8dbd4133bdac0f581e9a2966","9961914358014f5da1feb6f4bc0e0e9d","f3243034928a40e9999f256ec1c91c16","02d1570c794a43ebab260b1c04cb7215","c599771fccd24127a46cb1994a2febdd","e092c790f6fc4e13b3a48064215361bf","4284152481824d9f9d4fcbb84e7bfba1","c23bda26666740328a1170b6b8318771"],"text":"◯ 0=Normal\n◯ 1=Mild to moderate; patient slurs at least some words and at worst, can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mute/ anarthric\n◯ Intubated or other physical barrier.","text_display":"◯ 0=Normal\n◯ 1=Mild to moderate; patient slurs at least some words and at worst, can be understood with some difficulty\n◯ 2=Severe; patient's speech is so slurred as to be unintelligible in the absence of or out of proportion to any dysphasia, or is mute/ anarthric\n◯ Intubated or other physical barrier.","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.5920439176261425,"confidence_rate":0.9982792525744459},{"cnt":[[1133,1130],[1164,1130],[1164,1163],[1133,1163]],"region":{"top_left_x":1132,"top_left_y":1130,"width":33,"height":33},"line":78,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4e4b7a4c5b5f43aea5c14200a9db91fd","type":"form_field","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"","text_display":"◯","subtype":"circle"},{"cnt":[[1166,1138],[1257,1138],[1257,1164],[1166,1164]],"region":{"top_left_x":1165,"top_left_y":1138,"width":93,"height":27},"line":79,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"26346ed68530409f98f9922eb7d6592e","type":"text","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"0=Normal","text_display":" 0=Normal","confidence":0.9616409528007352,"confidence_rate":0.9969957427686993},{"cnt":[[1133,1174],[1164,1174],[1164,1207],[1133,1207]],"region":{"top_left_x":1132,"top_left_y":1173,"width":33,"height":34},"line":80,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"b9538d2647674c79b9d69d009ec43dcf","type":"form_field","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1166,1182],[1751,1182],[1751,1208],[1166,1208]],"region":{"top_left_x":1165,"top_left_y":1181,"width":586,"height":27},"line":81,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"da40ac0a8dbd4133bdac0f581e9a2966","type":"text","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"1=Mild to moderate; patient slurs at least some words and at worst,","text_display":" 1=Mild to moderate; patient slurs at least some words and at worst,","confidence":0.8908488763863716,"confidence_rate":0.9983960033751726},{"cnt":[[1174,1207],[1511,1207],[1511,1232],[1174,1232]],"region":{"top_left_x":1173,"top_left_y":1206,"width":338,"height":27},"line":82,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"9961914358014f5da1feb6f4bc0e0e9d","type":"text","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"can be understood with some difficulty","text_display":" can be understood with some difficulty","confidence":1,"confidence_rate":1},{"cnt":[[1132,1237],[1166,1237],[1166,1269],[1132,1269]],"region":{"top_left_x":1131,"top_left_y":1236,"width":35,"height":34},"line":83,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f3243034928a40e9999f256ec1c91c16","type":"form_field","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1170,1247],[1732,1247],[1732,1273],[1170,1273]],"region":{"top_left_x":1169,"top_left_y":1247,"width":563,"height":27},"line":84,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"02d1570c794a43ebab260b1c04cb7215","type":"text","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"2=Severe; patient's speech is so slurred as to be unintelligible in","text_display":" 2=Severe; patient's speech is so slurred as to be unintelligible in","confidence":0.5920439176261425,"confidence_rate":0.9927462356125514},{"cnt":[[1196,1272],[1755,1272],[1755,1298],[1196,1298]],"region":{"top_left_x":1195,"top_left_y":1272,"width":560,"height":26},"line":85,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c599771fccd24127a46cb1994a2febdd","type":"text","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"the absence of or out of proportion to any dysphasia, or is mute/","text_display":" the absence of or out of proportion to any dysphasia, or is mute/","confidence":0.98876953125,"confidence_rate":0.9998386700633775},{"cnt":[[1196,1297],[1279,1297],[1279,1317],[1196,1317]],"region":{"top_left_x":1195,"top_left_y":1296,"width":84,"height":22},"line":86,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"e092c790f6fc4e13b3a48064215361bf","type":"text","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"anarthric","text_display":" anarthric","confidence":1,"confidence_rate":1},{"cnt":[[1132,1322],[1166,1322],[1166,1357],[1132,1357]],"region":{"top_left_x":1131,"top_left_y":1322,"width":35,"height":35},"line":87,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"4284152481824d9f9d4fcbb84e7bfba1","type":"form_field","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"","text_display":"\n◯","subtype":"circle"},{"cnt":[[1171,1332],[1471,1332],[1471,1358],[1171,1358]],"region":{"top_left_x":1171,"top_left_y":1332,"width":301,"height":26},"line":88,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c23bda26666740328a1170b6b8318771","type":"text","conversion_output":false,"parent_id":"6a40cf9e3ff64d9aafa9aadbd6b5ccc7","text":"Intubated or other physical barrier.","text_display":" Intubated or other physical barrier.","confidence":1,"confidence_rate":1},{"cnt":[[481,1395],[514,1395],[514,1419],[481,1419]],"region":{"top_left_x":480,"top_left_y":1394,"width":34,"height":26},"line":89,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"a2cbf6409bbb4b4fb9acc219f342953f","type":"simple_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"21","text_display":"21","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[582,1395],[1077,1395],[1077,1421],[582,1421]],"region":{"top_left_x":581,"top_left_y":1394,"width":496,"height":27},"line":90,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"91eee42caa9149cfa2e65ce3e4aa8023","type":"simple_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"Explain if intubated or other physical barrier (Dysarthria):","text_display":"Explain if intubated or other physical barrier (Dysarthria):","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9326171875,"confidence_rate":0.9989273377889406},{"cnt":[[481,1556],[516,1556],[516,1584],[481,1584]],"region":{"top_left_x":480,"top_left_y":1555,"width":37,"height":30},"line":91,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"658d2fcb50ad4f81992c165368f993e0","type":"simple_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","text":"22","text_display":"22","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[538,1470],[1121,1470],[1121,1666],[538,1666]],"region":{"top_left_x":538,"top_left_y":1469,"width":583,"height":198},"line":92,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"83d6bc50cd964a3bab071805386dac65","type":"complex_cell","conversion_output":false,"parent_id":"6ade78fdaaf840af9456722ca1d56077","children_ids":["bc86d0679c2f4c7abed9c7f72a5ee454","31c9b90c703d4e60a6837a8bf5e70a09","3d3b22bcc47145bdac333343dd074b4f","c7807a0367924f8b96c5b9406e35f8d8","3232ac749a574508b7322b043da9afb9","0e169013cbd14814b8ae8153a630da68","13d71a21b26044b8b9d7b10a250ad4c9","ec0946d3a40d4e51be2f9aa3dc4060a0"],"text":"\\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumplent information to Idently neglect may be obtained during the prior testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the cutaneous stimuli are normal, the score is nomial. If the patient has aphasla but does appear to athend to both sides, the score is nomial. The presence of visual spattal neglect or anosagnosia may also be taken as evidence of abnormally. Since the aboormally is scored only if present, the them is never untestable. Coma Score \"2\".\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n(11) Extinction and Inattention (Neglect) \\\\\nSumplent information to Idently neglect may be obtained during the prior testing. If the patient has a severe visual loss preventing visual double simultaneous stimulation, and the cutaneous stimuli are normal, the score is nomial. If the patient has aphasla but does appear to athend to both sides, the score is nomial. The presence of visual spattal neglect or anosagnosia may also be taken as evidence of abnormally. Since the aboormally is scored only if present, the them is never untestable. Coma Score \"2\".\n\\end{tabular}","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.09103163507967166,"confidence_rate":0.9880673924181446},{"cnt":[[653,1474],[1007,1474],[1007,1503],[653,1503]],"region":{"top_left_x":652,"top_left_y":1473,"width":356,"height":30},"line":93,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"bc86d0679c2f4c7abed9c7f72a5ee454","type":"text","conversion_output":false,"parent_id":"83d6bc50cd964a3bab071805386dac65","text":"(11) Extinction and Inattention (Neglect)","text_display":"(11) Extinction and Inattention (Neglect)","confidence":0.990234375,"confidence_rate":0.9997866831585708},{"cnt":[[552,1523],[1107,1523],[1107,1546],[552,1546]],"region":{"top_left_x":551,"top_left_y":1523,"width":556,"height":24},"line":94,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"31c9b90c703d4e60a6837a8bf5e70a09","type":"text","conversion_output":false,"parent_id":"83d6bc50cd964a3bab071805386dac65","text":"Sumplent information to Idently neglect may be obtained during the prior","text_display":"\nSumplent information to Idently neglect may be obtained during the prior","confidence":0.5243008270627351,"confidence_rate":0.9916494808804773},{"cnt":[[561,1542],[1096,1542],[1096,1565],[561,1565]],"region":{"top_left_x":561,"top_left_y":1542,"width":536,"height":24},"line":95,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3d3b22bcc47145bdac333343dd074b4f","type":"text","conversion_output":false,"parent_id":"83d6bc50cd964a3bab071805386dac65","text":"testing. If the patient has a severe visual loss preventing visual double","text_display":" testing. If the patient has a severe visual loss preventing visual double","confidence":0.7312861428234084,"confidence_rate":0.9959958527340202},{"cnt":[[541,1561],[1121,1561],[1121,1582],[541,1582]],"region":{"top_left_x":540,"top_left_y":1561,"width":581,"height":21},"line":96,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"c7807a0367924f8b96c5b9406e35f8d8","type":"text","conversion_output":false,"parent_id":"83d6bc50cd964a3bab071805386dac65","text":"simultaneous stimulation, and the cutaneous stimuli are normal, the score is","text_display":" simultaneous stimulation, and the cutaneous stimuli are normal, the score is","confidence":0.33743765707172835,"confidence_rate":0.9866775096007118},{"cnt":[[546,1580],[1112,1580],[1112,1604],[546,1604]],"region":{"top_left_x":546,"top_left_y":1580,"width":567,"height":24},"line":97,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"3232ac749a574508b7322b043da9afb9","type":"text","conversion_output":false,"parent_id":"83d6bc50cd964a3bab071805386dac65","text":"nomial. If the patient has aphasla but does appear to athend to both sides,","text_display":" nomial. If the patient has aphasla but does appear to athend to both sides,","confidence":0.09103163507967166,"confidence_rate":0.9704874068155535},{"cnt":[[544,1599],[1115,1599],[1115,1623],[544,1623]],"region":{"top_left_x":543,"top_left_y":1599,"width":573,"height":24},"line":98,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"0e169013cbd14814b8ae8153a630da68","type":"text","conversion_output":false,"parent_id":"83d6bc50cd964a3bab071805386dac65","text":"the score is nomial. The presence of visual spattal neglect or anosagnosia","text_display":" the score is nomial. The presence of visual spattal neglect or anosagnosia","confidence":0.42427836958672643,"confidence_rate":0.9892059504481501},{"cnt":[[559,1621],[1104,1621],[1104,1644],[559,1644]],"region":{"top_left_x":558,"top_left_y":1621,"width":547,"height":24},"line":99,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"13d71a21b26044b8b9d7b10a250ad4c9","type":"text","conversion_output":false,"parent_id":"83d6bc50cd964a3bab071805386dac65","text":"may also be taken as evidence of abnormally. Since the aboormally is","text_display":" may also be taken as evidence of abnormally. Since the aboormally is","confidence":0.3189173292092766,"confidence_rate":0.9844667897345022},{"cnt":[[563,1640],[1096,1640],[1096,1664],[563,1664]],"region":{"top_left_x":562,"top_left_y":1640,"width":535,"height":24},"line":100,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ec0946d3a40d4e51be2f9aa3dc4060a0","type":"text","conversion_output":false,"parent_id":"83d6bc50cd964a3bab071805386dac65","text":"scored only if present, the them is never untestable. Coma Score \"2\".","text_display":" scored only if present, the them is never untestable. 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of assessor: \\\\\nThe assessor must be a study team member who has completed mRS certification.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nName of assessor: \\\\\nThe assessor must be a study team member who has completed mRS certification.\n\\end{tabular}","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99365234375,"confidence_rate":0.999903924878707},{"cnt":[[587,1827],[755,1827],[755,1848],[587,1848]],"region":{"top_left_x":587,"top_left_y":1826,"width":169,"height":23},"line":36,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ee208873099e41538e57f4ee655a5e00","type":"text","conversion_output":false,"parent_id":"dd8d271d128d486ca8c84b8ab3447748","text":"Name of assessor:","text_display":"Name of 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9","confidence":1,"confidence_rate":1},{"cnt":[[799,520],[1435,520],[1435,571],[799,571]],"region":{"top_left_x":799,"top_left_y":519,"width":637,"height":53},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dbfdf0f35434befa8f11cf26e6fe44c","type":"text","conversion_output":true,"parent_id":"bc05410bdefb4ac6aaa52e7430c45c48","text":"Glasgow Outcome Scale (GOS)","text_display":" Glasgow Outcome Scale (GOS)}","confidence":0.9479207992553711,"confidence_rate":0.9983300108205071},{"cnt":[[546,645],[1704,645],[1704,677],[546,677]],"region":{"top_left_x":545,"top_left_y":644,"width":1159,"height":33},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b731af2f6ea9407bad442848afd8b72b","type":"text","conversion_output":true,"text":"Note: The scale presented here is based on the original article by Jennett and Bond. It has become common practice","text_display":"\n\nNote: The scale presented here is based on the original article by Jennett and Bond. It has become common practice","confidence":0.99609375,"confidence_rate":0.9999671106306055},{"cnt":[[546,675],[1708,675],[1708,707],[546,707]],"region":{"top_left_x":545,"top_left_y":674,"width":1164,"height":33},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0ba50b926b1340a78036f79591f96a6c","type":"text","conversion_output":true,"text":"in elinical trial administration, however, to use a modified version that places the scores in reverse order (i e., \"good","text_display":" in elinical trial administration, however, to use a modified version that places the scores in reverse order (i e., \"good","confidence":0.42465053602231045,"confidence_rate":0.9932255214482869},{"cnt":[[546,700],[1008,700],[1008,737],[546,737]],"region":{"top_left_x":545,"top_left_y":700,"width":463,"height":37},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8eb8133c27914df4b95a57156554893d","type":"text","conversion_output":true,"text":"recovery\" \\(=1\\), \"moderate disability\" \\(=2\\), etc.).","text_display":" recovery\" \\(=1\\), \"moderate disability\" \\(=2\\), etc.).","confidence":0.9907460119575262,"confidence_rate":0.9998424349198343},{"cnt":[[539,846],[1729,846],[1729,1521],[539,1521]],"region":{"top_left_x":539,"top_left_y":846,"width":1191,"height":676},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6091981225f44cb6b60253ddb44c09a2","type":"table","conversion_output":true,"children_ids":["ee4aff85c1334192a582a0a48b0b5811","e74fe21e0b254b1aa0ae87a4687737c0","d2519c69de744ae5b3a97d1608ac9006","9e55dfbef1844d249ab7d9a22bda5859","e7fe9cb228b7433e99d1aca1208a2a4e","4e93180dd0454a828fc609146b44e531","650ca83ac4634b81a139cddd1f1e8ac4","d3b5016a555b4886a46b1fb9fd9edec9","6846aef6cd8c4fec8a6838afce0be642","b4595460fad846cf86dbc4c7c60e7e21","c6fd7ee9174f4e50a695b06a396b88b1","6b1299873d9a4dcc96a96803e870b488","18ba8db8afa440f6ac2bce7f2e0eeff4","86894e28324b4c068729156aa29a21e7","b2b69dd044bc428f8c6550e468b00cf9","23df3f38ebf14890bba133a0b472ad06","5d0e64a8febc496d95caade2a4978940","6eb64ae8a2f64cb5b51573932ba20593","5ebfcaa06a53417baeba1a36d4d46072","27cee1ed07664b77a36a0a8911dd3907"],"text":"\\begin{tabular}{|l|l|}\n\\hline Score & Description \\\\\n\\hline 1 & DEATH \\\\\n\\hline 2 & PERSISTENT VEGETATIVE STATE Patient exhibits no obvious cortical function. \\\\\n\\hline 3 & SEVERE DISABILITY (Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both. \\\\\n\\hline 4 & MODERATE DISABILITY (Disabled but independent). Patient is independent as far as daily life is concerned. The disabilities found include varying degrees of dysphasia, hemiparesis, or ataxia, as well as intellectual and memory deficits and personality changes. \\\\\n\\hline 5 & GOOD RECOVERY Resumption of normal activities even though there may be minor neurological or psychological deficits. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Score & Description \\\\\n\\hline 1 & DEATH \\\\\n\\hline 2 & PERSISTENT VEGETATIVE STATE Patient exhibits no obvious cortical function. \\\\\n\\hline 3 & SEVERE DISABILITY (Conscious but disabled). Patient depends upon others for daily support due to mental or physical disability or both. \\\\\n\\hline 4 & MODERATE DISABILITY (Disabled but independent). 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The letter is L. You will have one minute. Ready? Begin.\" \\\\\nRecord the study participant's responses in the following table.\n\\end{tabular}} \\\\\n\\hline & Acceptable & & Acceptable \\\\\n\\hline 1. & □ & 21. & □ \\\\\n\\hline 2. & □ & 22. & □ \\\\\n\\hline 3. & □ & 23. & □ \\\\\n\\hline 4. & □ & 24. & □ \\\\\n\\hline 5. & □ & 25. & □ \\\\\n\\hline 6. & □ & 26. & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-296.jpg?height=37\\&width=33\\&top_left_y=1079\\&top_left_x=1626) \\\\\n\\hline 7. & □ & 27. & □ \\\\\n\\hline 8. & □ & 28. & □ \\\\\n\\hline 9. & □ & 29. & □ \\\\\n\\hline 10. & □ & 30. & □ \\\\\n\\hline 11. & □ & 31. & □ \\\\\n\\hline 12. & □ & 32. & □ \\\\\n\\hline 13. & □ & 33. & □ \\\\\n\\hline 14. & □ & 34. & □ \\\\\n\\hline 15. & □ & 35. & □ \\\\\n\\hline 16. & □ & 36. & □ \\\\\n\\hline 17. & □ & 37. & □ \\\\\n\\hline 18. & □ & 38. & □ \\\\\n\\hline 19. & □ & 39. & □ \\\\\n\\hline 20. & □ & 40. & □ \\\\\n\\hline \\multicolumn{4}{|c|}{\\begin{tabular}{l}\nTotal words generated: □ \\\\\nTotal acceptable words: □\n\\end{tabular}} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|}\n\\hline \\multicolumn{4}{|c|}{Letter L} \\\\\n\\hline \\multicolumn{4}{|c|}{\\begin{tabular}{l}\nInstruct the study participant as follows: \\\\\n\"I am going to say a letter and I want you to name, as fast as you can, as many words as you can think of which start with this letter. The letter is L. You will have one minute. Ready? Begin.\" \\\\\nRecord the study participant's responses in the following table.\n\\end{tabular}} \\\\\n\\hline & Acceptable & & Acceptable \\\\\n\\hline 1. & □ & 21. & □ \\\\\n\\hline 2. & □ & 22. & □ \\\\\n\\hline 3. & □ & 23. & □ \\\\\n\\hline 4. & □ & 24. & □ \\\\\n\\hline 5. & □ & 25. & □ \\\\\n\\hline 6. & □ & 26. & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-296.jpg?height=37\\&width=33\\&top_left_y=1079\\&top_left_x=1626) \\\\\n\\hline 7. & □ & 27. & □ \\\\\n\\hline 8. & □ & 28. & □ \\\\\n\\hline 9. & □ & 29. & □ \\\\\n\\hline 10. & □ & 30. & □ \\\\\n\\hline 11. & □ & 31. & □ \\\\\n\\hline 12. & □ & 32. & □ \\\\\n\\hline 13. & □ & 33. & □ \\\\\n\\hline 14. & □ & 34. & □ \\\\\n\\hline 15. & □ & 35. & □ \\\\\n\\hline 16. & □ & 36. & □ \\\\\n\\hline 17. & □ & 37. & □ \\\\\n\\hline 18. & □ & 38. & □ \\\\\n\\hline 19. & □ & 39. & □ \\\\\n\\hline 20. & □ & 40. & □ \\\\\n\\hline \\multicolumn{4}{|c|}{\\begin{tabular}{l}\nTotal words generated: □ \\\\\nTotal 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\\multicolumn{2}{|c|}{Learning Trials} & Delayed Recall Trial ( \\(20-25 min\\).) \\\\\n\\hline LION & Trial 1 & Trial 3 & Trial 4 \\\\\n\\hline EMERALD & & & \\\\\n\\hline & & & \\\\\n\\hline HORSE & & & \\\\\n\\hline TENT & & & \\\\\n\\hline SAPPHIRE & & & \\\\\n\\hline HOTEL & & & \\\\\n\\hline CAVE & & & \\\\\n\\hline OPAL & & & \\\\\n\\hline TIGER & & & \\\\\n\\hline PEARL & & & \\\\\n\\hline COW & & & \\\\\n\\hline HUT & & & \\\\\n\\hline Total correct responses = & & & \\\\\n\\hline & & & 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Credit only one item when people name the same animal at","confidence":0.9970703125,"confidence_rate":0.9999681093407484},{"cnt":[[490,984],[1132,984],[1132,1027],[490,1027]],"region":{"top_left_x":489,"top_left_y":983,"width":644,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e12729f7a904625af05e3f7a773e9e0","type":"text","conversion_output":true,"text":"different developmental stages (e.g., sheep, lamb).","text_display":" different developmental stages (e.g., sheep, lamb).","confidence":1,"confidence_rate":1},{"cnt":[[490,1051],[1712,1048],[1712,1096],[490,1098]],"region":{"top_left_x":489,"top_left_y":1048,"width":1224,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"296318aa52da40618acae064f792bcd1","type":"text","conversion_output":true,"text":"Note: These minimalist initial instructions date back to an early research study on verbal fluency","text_display":"\n\nNote: These minimalist initial instructions date back to an early research study on verbal fluency","confidence":1,"confidence_rate":1},{"cnt":[[490,1089],[1669,1089],[1669,1132],[490,1132]],"region":{"top_left_x":489,"top_left_y":1089,"width":1181,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7383bed4760744c392aa3d912284fae4","type":"text","conversion_output":true,"text":"in aging and dementia by Wilma Rosen (1980) in which subjects were instructed to \"give the","text_display":" in aging and dementia by Wilma Rosen (1980) in which subjects were instructed to \"give the","confidence":1,"confidence_rate":1},{"cnt":[[490,1126],[1661,1126],[1661,1171],[490,1171]],"region":{"top_left_x":489,"top_left_y":1125,"width":1172,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e38eecfe13a46c5b06c65f9c1c8a9d7","type":"text","conversion_output":true,"text":"names of as many animals as you can think of' for 60 seconds. These very brief instructions","text_display":" names of as many animals as you can think of' for 60 seconds. These very brief instructions","confidence":0.4104151725769043,"confidence_rate":0.9910445229761362},{"cnt":[[490,1164],[1644,1164],[1644,1205],[490,1205]],"region":{"top_left_x":489,"top_left_y":1164,"width":1155,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b331c0cea71847d19d64c41c154a8622","type":"text","conversion_output":true,"text":"have been subsequently used in several normative studies (e.g., Tombaugh et al., 1999 and","text_display":" have been subsequently used in several normative studies (e.g., Tombaugh et al., 1999 and","confidence":1,"confidence_rate":1},{"cnt":[[490,1197],[1644,1197],[1644,1240],[490,1240]],"region":{"top_left_x":489,"top_left_y":1196,"width":1155,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcc9b2d8dbed4edf8f38849326e88686","type":"text","conversion_output":true,"text":"Mayo's MOANS studies such as Lucas et al., 1998) and in some other recent studies of the","text_display":" Mayo's MOANS studies such as Lucas et al., 1998) and in some other recent studies of the","confidence":1,"confidence_rate":1},{"cnt":[[490,1233],[1588,1233],[1588,1278],[490,1278]],"region":{"top_left_x":489,"top_left_y":1233,"width":1099,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bb9e2b732784d4ba9f4d139dad28c10","type":"text","conversion_output":true,"text":"efficacy of verbal fluency as a diagnostic tool for dementia (e.g., Canning et al., 2004).","text_display":" efficacy of verbal fluency as a diagnostic tool for dementia (e.g., Canning et al., 2004).","confidence":1,"confidence_rate":1},{"cnt":[[490,2269],[1182,2269],[1182,2310],[490,2310]],"region":{"top_left_x":489,"top_left_y":2268,"width":693,"height":42},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"50244dbfecf6417c841a88e69a84985a","type":"page_info","conversion_output":false,"text":"12GEN130355_M29093_Animal 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Inc.","text_display":"","confidence":0.9883262466473752,"confidence_rate":0.9996086623730838},{"cnt":[[455,2411],[902,2411],[902,2451],[455,2451]],"region":{"top_left_x":455,"top_left_y":2410,"width":448,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b69581bbc4b4323b9f7d0d6417bd9f2","type":"page_info","conversion_output":false,"text":"94/Protocol ML29093, Version 3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f30d03a278ce49839eeb9928281950ee","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9917177988746166,"confidence_rate":0.9998720591219105},{"cnt":[[370,2608],[698,2608],[698,2649],[370,2649]],"region":{"top_left_x":369,"top_left_y":2608,"width":330,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cb473e96c984d54863e409a526bb8cd","type":"page_info","conversion_output":false,"text":"639/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-304","page":304,"lines":[{"cnt":[[713,357],[1523,357],[1523,458],[713,458]],"region":{"top_left_x":713,"top_left_y":356,"width":811,"height":102},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92a5c99343bb4eafb8df756c9ff769ea","type":"section_header","conversion_output":false,"children_ids":["7ae9da584cb84636b3cddb1a557d4edf","335639d6528843ccb9c21906ac23782b"],"text":"","text_display":""},{"cnt":[[911,361],[1321,361],[1321,410],[911,410]],"region":{"top_left_x":910,"top_left_y":360,"width":412,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ae9da584cb84636b3cddb1a557d4edf","type":"text","conversion_output":true,"parent_id":"92a5c99343bb4eafb8df756c9ff769ea","text":"Appendix 11 (cont.)","text_display":"\n\n\\section*{Appendix 11 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[718,404],[1517,404],[1517,453],[718,453]],"region":{"top_left_x":717,"top_left_y":403,"width":800,"height":51},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"335639d6528843ccb9c21906ac23782b","type":"text","conversion_output":true,"parent_id":"92a5c99343bb4eafb8df756c9ff769ea","text":"Cognitive and Behavioral Assessments","text_display":" \\\\ Cognitive and Behavioral Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[606,556],[1635,556],[1635,621],[606,621]],"region":{"top_left_x":605,"top_left_y":556,"width":1030,"height":65},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b73fc47825846d19c7358e3ea49f1ee","type":"section_header","conversion_output":false,"children_ids":["a119ced8c8674fa5939af45353d6c460"],"text":"","text_display":""},{"cnt":[[612,563],[1629,563],[1629,617],[612,617]],"region":{"top_left_x":612,"top_left_y":562,"width":1017,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a119ced8c8674fa5939af45353d6c460","type":"text","conversion_output":true,"parent_id":"1b73fc47825846d19c7358e3ea49f1ee","text":"G. Boston Naming Test (BNT) 15-Item Short Form","text_display":"\n\n\\section*{G. 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(used for fixing hair) & & & \\(\\_\\_\\_\\_\\) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-304.jpg?height=25\\&width=85\\&top_left_y=1099\\&top_left_x=1344) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 3. toothbrush. (used in the mouth) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-304.jpg?height=25\\&width=83\\&top_left_y=1238\\&top_left_x=1344) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 4. octopus (an ocean animal) & & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 5. bench (used for sitting) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 6. yolcano (a kind of mountain) & & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 7. canoe (used in the water) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-304.jpg?height=24\\&width=83\\&top_left_y=1786\\&top_left_x=1344) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 8. beaver \\(\\_\\_\\_\\_\\) (an animal) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-304.jpg?height=23\\&width=90\\&top_left_y=1924\\&top_left_x=1606) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline Item & Correct Response & Latency Seconds & Stimulus Cue & Phonemic Cue & Multiple Choice \\\\\n\\hline 1. house (home) (a kind of building) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 2. comb . . . . . . . . . . . (used for fixing hair) & & & \\(\\_\\_\\_\\_\\) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-304.jpg?height=25\\&width=85\\&top_left_y=1099\\&top_left_x=1344) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 3. toothbrush. (used in the mouth) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-304.jpg?height=25\\&width=83\\&top_left_y=1238\\&top_left_x=1344) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 4. octopus (an ocean animal) & & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 5. bench (used for sitting) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 6. yolcano (a kind of mountain) & & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 7. canoe (used in the water) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & ![](https://cdn.mathpix.com/cropped/528b53d6-37a2-475c-be9a-d1b60d0ac718-304.jpg?height=24\\&width=83\\&top_left_y=1786\\&top_left_x=1344) & \\(\\_\\_\\_\\_\\) \\\\\n\\hline 8. beaver \\(\\_\\_\\_\\_\\) (an animal) & & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & \\(\\_\\_\\_\\_\\) & 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The amount of assistance","confidence":1,"confidence_rate":1},{"cnt":[[460,1070],[1738,1070],[1738,1111],[460,1111]],"region":{"top_left_x":459,"top_left_y":1069,"width":1280,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5af8d5fdea744d53930f07226a089866","type":"text","conversion_output":true,"text":"provided will be recorded with assignment of a Functional Ambulation Category (FAC).","text_display":" provided will be recorded with assignment of a Functional Ambulation Category (FAC).","confidence":1,"confidence_rate":1},{"cnt":[[460,1109],[1025,1109],[1025,1149],[460,1149]],"region":{"top_left_x":459,"top_left_y":1108,"width":566,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee125499b7b94375aec945dcdf2d73b9","type":"text","conversion_output":true,"text":"See FAC for description of procedure.","text_display":" See FAC for description of procedure.","confidence":1,"confidence_rate":1},{"cnt":[[455,1160],[793,1160],[793,1205],[455,1205]],"region":{"top_left_x":455,"top_left_y":1160,"width":338,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f42d7718047643579eedd957ce6b3da4","type":"section_header","conversion_output":false,"children_ids":["cd791761912c48f18ace1d7ae0fc4ff2"],"text":"","text_display":""},{"cnt":[[460,1164],[788,1164],[788,1201],[460,1201]],"region":{"top_left_x":459,"top_left_y":1164,"width":330,"height":37},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd791761912c48f18ace1d7ae0fc4ff2","type":"text","conversion_output":true,"parent_id":"f42d7718047643579eedd957ce6b3da4","text":"Test Administration:","text_display":"\n\n\\section*{Test Administration:}","confidence":0.9985356330871582,"confidence_rate":0.9999413841121408},{"cnt":[[460,1220],[1712,1220],[1712,1261],[460,1261]],"region":{"top_left_x":459,"top_left_y":1220,"width":1254,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5bdb707f058c4df1ae535e181f8a3fdd","type":"text","conversion_output":true,"text":"Course Layout: The walking Course is established indoors on a level, non-carpeted","text_display":"\n\nCourse Layout: The walking Course is established indoors on a level, non-carpeted","confidence":1,"confidence_rate":1},{"cnt":[[460,1259],[1760,1259],[1760,1300],[460,1300]],"region":{"top_left_x":459,"top_left_y":1258,"width":1301,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12522b383daf44d1927993ffb950b80b","type":"text","conversion_output":true,"text":"surface measuring a length of 14 meters. The course is marked with tape at 0 meters, 2","text_display":" surface measuring a length of 14 meters. 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Instruct the subject in the goal of the 10 meter walk test while the subject is seated:","text_display":"\n1. Instruct the subject in the goal of the 10 meter walk test while the subject is seated:","confidence":1,"confidence_rate":1},{"cnt":[[524,1654],[1777,1654],[1777,1697],[524,1697]],"region":{"top_left_x":524,"top_left_y":1654,"width":1253,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"107682b2901548c0926fe7bbf60a4f27","type":"text","conversion_output":true,"text":"\"You are going to walk a distance of about \\(4 0\\) feet. We will repeat this distance","text_display":"\n\"You are going to walk a distance of about \\(4 0\\) feet. We will repeat this distance","confidence":0.9633965492248535,"confidence_rate":0.9995903018979437},{"cnt":[[524,1697],[1723,1697],[1723,1740],[524,1740]],"region":{"top_left_x":524,"top_left_y":1697,"width":1200,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e8cf0dab0204ad4bd7c1453de6d4714","type":"text","conversion_output":true,"text":"four times. The first two times will be completed at your comfortable pace,","text_display":" four times. The first two times will be completed at your comfortable pace,","confidence":1,"confidence_rate":1},{"cnt":[[524,1740],[1693,1740],[1693,1781],[524,1781]],"region":{"top_left_x":524,"top_left_y":1740,"width":1169,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5ce7089d1734afcb0dff423b0d35c5e","type":"text","conversion_output":true,"text":"the final two times you will walk as quickly and safely as you can. Do you","text_display":" the final two times you will walk as quickly and safely as you can. Do you","confidence":1,"confidence_rate":1},{"cnt":[[524,1783],[879,1783],[879,1824],[524,1824]],"region":{"top_left_x":524,"top_left_y":1783,"width":355,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db24d566993f45da8fa8f7a5c3ca9372","type":"text","conversion_output":true,"text":"have any questions?\"","text_display":" have any questions?\"","confidence":1,"confidence_rate":1},{"cnt":[[458,1841],[1257,1841],[1257,1882],[458,1882]],"region":{"top_left_x":457,"top_left_y":1841,"width":800,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d133b150756e4f4f9a7546faa999ffbd","type":"text","conversion_output":true,"text":"2. Demonstrate where you want the subject to walk.","text_display":"\n2. Demonstrate where you want the subject to walk.","confidence":1,"confidence_rate":1},{"cnt":[[460,1899],[1729,1899],[1729,1940],[460,1940]],"region":{"top_left_x":459,"top_left_y":1899,"width":1271,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"217c4d3989f94417bba83527c4249d61","type":"text","conversion_output":true,"text":"3. Walk the subject to the start line (0 meters). Provide the subject with the following","text_display":"\n3. Walk the subject to the start line (0 meters). Provide the subject with the following","confidence":0.8994629383087158,"confidence_rate":0.998861321593394},{"cnt":[[524,1938],[709,1938],[709,1979],[524,1979]],"region":{"top_left_x":524,"top_left_y":1937,"width":185,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e9f4a48c9f947dcb7e2c0758040f183","type":"text","conversion_output":true,"text":"instructions:","text_display":" instructions:","confidence":1,"confidence_rate":1},{"cnt":[[524,1998],[1764,1998],[1764,2039],[524,2039]],"region":{"top_left_x":524,"top_left_y":1998,"width":1240,"height":41},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4768123fe6564b839b0f37dfae4191c3","type":"text","conversion_output":true,"text":"\"You will walk at a comfortable pace to the chair.\" (DO NOT refer to the tape on","text_display":"\n\"You will walk at a comfortable pace to the chair.\" (DO NOT refer to the tape on","confidence":1,"confidence_rate":1},{"cnt":[[524,2041],[1278,2041],[1278,2082],[524,2082]],"region":{"top_left_x":524,"top_left_y":2041,"width":755,"height":41},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dbb33eaf10e4dee948929ee6f678bb2","type":"text","conversion_output":true,"text":"the floor.) The start command is \"Ready and Go\".","text_display":" the floor.) The start command is \"Ready and Go\".","confidence":1,"confidence_rate":1},{"cnt":[[458,2097],[1768,2097],[1768,2140],[458,2140]],"region":{"top_left_x":457,"top_left_y":2096,"width":1312,"height":44},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"876de4cb8637442fafe579d09ce72da4","type":"text","conversion_output":true,"text":"4. When you and the subject are ready, say \"Ready and Go\". If the subject starts too","text_display":"\n4. When you and the subject are ready, say \"Ready and Go\". If the subject starts too","confidence":1,"confidence_rate":1},{"cnt":[[524,2140],[786,2140],[786,2185],[524,2185]],"region":{"top_left_x":524,"top_left_y":2139,"width":263,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a90088a33db140d2bf54240d8eba6ccb","type":"text","conversion_output":true,"text":"early, start again.","text_display":" early, start again.","confidence":1,"confidence_rate":1},{"cnt":[[460,2376],[857,2376],[857,2413],[460,2413]],"region":{"top_left_x":459,"top_left_y":2376,"width":399,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3ab588f09fb48879d50b13ab69b47a2","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9975602623308077,"confidence_rate":0.9999185793588832},{"cnt":[[460,2413],[900,2413],[900,2447],[460,2447]],"region":{"top_left_x":459,"top_left_y":2412,"width":442,"height":36},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a855699cc92847d9973676dc7fa206e6","type":"page_info","conversion_output":false,"text":"98/Protocol ML29093, Version 3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0979a01a23249d3ba66c16910df030a","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9888066703372698,"confidence_rate":0.9998268388954964},{"cnt":[[372,2608],[694,2608],[694,2645],[372,2645]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":37},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1916f68472944ef7b1bab960d70108cb","type":"page_info","conversion_output":false,"text":"643/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-308","page":308,"lines":[{"cnt":[[911,357],[1321,357],[1321,451],[911,451]],"region":{"top_left_x":910,"top_left_y":356,"width":412,"height":96},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a4f938ea6264271850a3b80fe53d5de","type":"section_header","conversion_output":false,"children_ids":["9e6541d81d7e42daa8673f9aa687dc3b","7f5e19df245a40bbb434b37be7e7a8a3"],"text":"","text_display":""},{"cnt":[[915,361],[1313,361],[1313,410],[915,410]],"region":{"top_left_x":915,"top_left_y":360,"width":398,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e6541d81d7e42daa8673f9aa687dc3b","type":"text","conversion_output":true,"parent_id":"1a4f938ea6264271850a3b80fe53d5de","text":"Appendix 12 (cont.)","text_display":"\n\n\\section*{Appendix 12 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[920,406],[1313,406],[1313,449],[920,449]],"region":{"top_left_x":919,"top_left_y":406,"width":394,"height":44},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f5e19df245a40bbb434b37be7e7a8a3","type":"text","conversion_output":true,"parent_id":"1a4f938ea6264271850a3b80fe53d5de","text":"10 Meter Walk Test","text_display":" 10 Meter Walk Test}","confidence":0.998046875,"confidence_rate":0.9999111387285874},{"cnt":[[458,507],[1003,507],[1003,552],[458,552]],"region":{"top_left_x":457,"top_left_y":507,"width":547,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72393547a403455ba16cd85988e3f83e","type":"text","conversion_output":true,"text":"5. Instructions for Recording Time:","text_display":"\n5. Instructions for Recording Time:","confidence":0.99951171875,"confidence_rate":0.9999877900620892},{"cnt":[[511,563],[1704,563],[1704,608],[511,608]],"region":{"top_left_x":511,"top_left_y":562,"width":1193,"height":47},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dda9dc34ec5e4caab54c59f63ef20b76","type":"text","conversion_output":true,"text":"□ START the stopwatch when the subject's first foot crosses the plane of the 2","text_display":"\n□ START the stopwatch when the subject's first foot crosses the plane of the 2","confidence":0.9975595474243164,"confidence_rate":0.9999702024520788},{"cnt":[[567,610],[724,610],[724,647],[567,647]],"region":{"top_left_x":567,"top_left_y":610,"width":158,"height":37},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c2ad0b9e39e44aea875d9f1aff5c539","type":"text","conversion_output":true,"text":"meter line","text_display":" meter 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When the subject is ready, have them repeat the SAME PROCEDURE except they","text_display":"\n6. 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Subject Instructions for the last 2 trials:","text_display":"\n7. Subject Instructions for the last 2 trials:","confidence":1,"confidence_rate":1},{"cnt":[[524,1775],[1755,1775],[1755,1820],[524,1820]],"region":{"top_left_x":524,"top_left_y":1774,"width":1232,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afb97b9e14ad446b89f0a9daf3cd5da6","type":"text","conversion_output":true,"text":"\"You are going to walk the same distances for two additional trials as quickly","text_display":"\n\"You are going to walk the same distances for two additional trials as quickly","confidence":1,"confidence_rate":1},{"cnt":[[524,1818],[1412,1818],[1412,1861],[524,1861]],"region":{"top_left_x":524,"top_left_y":1817,"width":888,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"142f00511b894fecb2eea2b10866b614","type":"text","conversion_output":true,"text":"and as safely as you can. Do you have any questions?\"","text_display":" and as safely as you can. Do you have any questions?\"","confidence":0.9990234375,"confidence_rate":0.9999831546307154},{"cnt":[[458,1873],[1747,1873],[1747,1919],[458,1919]],"region":{"top_left_x":457,"top_left_y":1873,"width":1290,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0754b58299d84d5a93b6729e2f972054","type":"text","conversion_output":true,"text":"8. When the subject is ready, walk the subject to the start line (0 meters). Provide the","text_display":"\n8. When the subject is ready, walk the subject to the start line (0 meters). 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When you and the subject are ready, say \"Ready and Go\". If the subject starts too","text_display":"\n9. When you and the subject are ready, say \"Ready and Go\". If the subject starts too","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[524,2161],[952,2161],[952,2202],[524,2202]],"region":{"top_left_x":524,"top_left_y":2161,"width":428,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fd061dc3afe41cebbc72fb2f6bc11b8","type":"text","conversion_output":true,"text":"early, have them start again.","text_display":" early, have them start again.","confidence":1,"confidence_rate":1},{"cnt":[[460,2376],[857,2376],[857,2413],[460,2413]],"region":{"top_left_x":459,"top_left_y":2376,"width":399,"height":37},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bff33ea1f4af4716ba53ed9dc65d81ce","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9975602623308077,"confidence_rate":0.9999185793588832},{"cnt":[[460,2411],[900,2411],[900,2447],[460,2447]],"region":{"top_left_x":459,"top_left_y":2410,"width":442,"height":38},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d077843d4df449cbac0a89318c6382fd","type":"page_info","conversion_output":false,"text":"99/Protocol ML29093, Version 3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4046bfab3feb405daff897bef5f44283","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.992694120279225,"confidence_rate":0.9998871956188562},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8952052bc204cf79f887bae77f726c7","type":"page_info","conversion_output":false,"text":"644/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-309","page":309,"lines":[{"cnt":[[911,357],[1321,357],[1321,453],[911,453]],"region":{"top_left_x":910,"top_left_y":356,"width":412,"height":98},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ab287c1c7804e23a1324a7fa8f67d94","type":"section_header","conversion_output":false,"children_ids":["f1a3ea45e4d645ba97e0a7201455c2ae","b6d0afaa51c2426ba8f72f255590e4b6"],"text":"","text_display":""},{"cnt":[[915,361],[1313,361],[1313,410],[915,410]],"region":{"top_left_x":915,"top_left_y":360,"width":398,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1a3ea45e4d645ba97e0a7201455c2ae","type":"text","conversion_output":true,"parent_id":"3ab287c1c7804e23a1324a7fa8f67d94","text":"Appendix 12 (cont.)","text_display":"\n\n\\section*{Appendix 12 (cont.)","confidence":1,"confidence_rate":1},{"cnt":[[920,404],[1313,404],[1313,449],[920,449]],"region":{"top_left_x":919,"top_left_y":403,"width":394,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6d0afaa51c2426ba8f72f255590e4b6","type":"text","conversion_output":true,"parent_id":"3ab287c1c7804e23a1324a7fa8f67d94","text":"10 Meter Walk Test","text_display":" 10 Meter Walk Test}","confidence":0.986328125,"confidence_rate":0.9993744595609526},{"cnt":[[460,507],[1003,507],[1003,552],[460,552]],"region":{"top_left_x":459,"top_left_y":507,"width":545,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2719e50aae364b8aa9c22c3abdb30499","type":"text","conversion_output":true,"text":"10. Instructions for Recording Time:","text_display":"\n10. 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hemorrhage","confidence":1,"confidence_rate":1},{"cnt":[[460,2045],[831,2045],[831,2082],[460,2082]],"region":{"top_left_x":459,"top_left_y":2045,"width":373,"height":37},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"867a7a0037114ceeb09c4dab6351c9e9","type":"text","conversion_output":true,"text":"- Subdural hematoma","text_display":"\n- Subdural hematoma","confidence":1,"confidence_rate":1},{"cnt":[[460,2105],[853,2105],[853,2146],[460,2146]],"region":{"top_left_x":459,"top_left_y":2105,"width":394,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e3784b910b54a3aa152ecaea51efcd3","type":"text","conversion_output":true,"text":"- Subdural hemorrhage","text_display":"\n- Subdural hemorrhage","confidence":1,"confidence_rate":1},{"cnt":[[460,2161],[866,2161],[866,2202],[460,2202]],"region":{"top_left_x":459,"top_left_y":2161,"width":407,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fbc70980d2e4a32b1cbf88364cd5e9b","type":"text","conversion_output":true,"text":"- Thalamus hemorrhage","text_display":"\n- Thalamus hemorrhage","confidence":1,"confidence_rate":1},{"cnt":[[460,2219],[1042,2219],[1042,2262],[460,2262]],"region":{"top_left_x":459,"top_left_y":2219,"width":583,"height":44},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d7bfdaba6474106a275d2ac9e815286","type":"text","conversion_output":true,"text":"- Traumatic intracranial hemorrhage","text_display":"\n- Traumatic intracranial hemorrhage","confidence":1,"confidence_rate":1},{"cnt":[[458,2376],[857,2376],[857,2413],[458,2413]],"region":{"top_left_x":457,"top_left_y":2376,"width":401,"height":37},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"833faa15a72d4d5fa1d5ffe233e5a008","type":"page_info","conversion_output":false,"text":"Alteplase-Genentech, Inc.","text_display":"","confidence":0.9990236759185791,"confidence_rate":0.9999674404968648},{"cnt":[[460,2411],[917,2411],[917,2447],[460,2447]],"region":{"top_left_x":459,"top_left_y":2410,"width":459,"height":38},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25aa22d52c5f48daa335833e14e6d9e7","type":"page_info","conversion_output":false,"text":"101/Protocol ML29093, Version 3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b839ec6bfca9453983a30f4efad626c8","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9912368957975559,"confidence_rate":0.9998645979984966},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b278db67f25473f83246d88c7aab355","type":"page_info","conversion_output":false,"text":"646/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"528b53d6-37a2-475c-be9a-d1b60d0ac718-311","page":311,"lines":[{"cnt":[[980,374],[1248,374],[1248,432],[980,432]],"region":{"top_left_x":979,"top_left_y":373,"width":270,"height":59},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a18f01363a404d5782252f182da79fd2","type":"section_header","conversion_output":false,"children_ids":["8b166fefb624483da7f7ae53f5951c95"],"text":"","text_display":""},{"cnt":[[984,378],[1242,378],[1242,428],[984,428]],"region":{"top_left_x":983,"top_left_y":378,"width":259,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b166fefb624483da7f7ae53f5951c95","type":"text","conversion_output":true,"parent_id":"a18f01363a404d5782252f182da79fd2","text":"Appendix 14","text_display":"\n\n\\section*{Appendix 14}","confidence":1,"confidence_rate":1},{"cnt":[[501,417],[1734,417],[1734,518],[501,518]],"region":{"top_left_x":500,"top_left_y":416,"width":1234,"height":102},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3195bdbca0344391b38dda4bb0b32ecf","type":"section_header","conversion_output":false,"children_ids":["b7ae47e8ca77466f8fc10c648802dcd8","7d37bf6935c2442e93b4a7e349ba526a"],"text":"","text_display":""},{"cnt":[[505,421],[1729,421],[1729,471],[505,471]],"region":{"top_left_x":504,"top_left_y":421,"width":1226,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7ae47e8ca77466f8fc10c648802dcd8","type":"text","conversion_output":true,"parent_id":"3195bdbca0344391b38dda4bb0b32ecf","text":"World Health Organization (WHO) Toxicity Grading Scale for","text_display":"\n\n\\section*{World Health Organization (WHO) Toxicity Grading Scale for","confidence":1,"confidence_rate":1},{"cnt":[[675,466],[1560,466],[1560,513],[675,513]],"region":{"top_left_x":674,"top_left_y":466,"width":886,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d37bf6935c2442e93b4a7e349ba526a","type":"text","conversion_output":true,"parent_id":"3195bdbca0344391b38dda4bb0b32ecf","text":"Determining the Severity of Adverse Events","text_display":" Determining the Severity of Adverse Events}","confidence":1,"confidence_rate":1},{"cnt":[[503,559],[1760,559],[1760,2179],[503,2179]],"region":{"top_left_x":502,"top_left_y":558,"width":1258,"height":1621},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3c09c726b03b4719a28c5e2cbb0f5636","type":"table","conversion_output":true,"children_ids":["8ae833553f4c41238347fb9a719a164e","d2f43750f35445d4a5603490bcd2870e","6657a97b94544425b24d982676de798d","f59d60e61b454757a464c03cda111dc0","b3dda2c373f94d6283e55b1ef6737a20","fb0f0481cdb7446baa53ebf5142a456c","e1650ae5f46e4c2797c062291db82276","bc1b8a883b70485aac8a512b5ccd7e95","0c1ccab2439a4579b5ba3b5affec9756","9a52815dc23344bd8dfcbc065950b7c6","efc171ca99fc4720823a1393aedc79a2","994b23d0d0dc4363a33b6b2d873693be","1c2d2486dea34078ac697fbf9dc1851b","4cd763c35f184b1382f90d591479d2cf","ca9c28283be14d2eb729cec4e10ff598","e4a05565fc8044d2820a9a6bd055b1a5","a60c858172944244b7022c621397e423","a3f38def81ef4a62aa7bbd490c1bcc46","088498f04782427bb3c951e0ccefa87c","21781c332b924c2ab4c03334c6524fe9","e8fb219207644e8188f0f65948ef6413","2d56522485264fe889add288b5f50b05","08820077a1d345d3b421530bfb43db90","07c73009302f46d18c41926f618838f2","9cfb696fd0774987a855c3f35e4ed732","9d696b302bd041628cde66073ccf070a","7b68724dfd0348479edd7c31d053871c","5594fa4521274d5aa86acde376062a0f","12cd9a290348420a96ca52c8c7937898","bf6e24a36ef24cc69c2fbb5d8a6a5333","d6bfeb361d6f4208a4433a7e246b7742","e9d6f39b00da450b9347920bccb3e539","dfac93020d8043d9b1883f36e10bf246","e50be7ba9afc4f308316be0f03a78b73","3dbab02ab0244e159e855d15a98f17bd","e1219438d2c84f4ba857a12f0dd2c316","dc82484ac58847ad85dfa36d2be408ba","a2d30376e4574195906c36d79feb6a23","d948fc9edfbf48bf954c9fb809fd9227","a88ace83279341a7bc0ea3d01ae7c097","2966abfd23ec481ea18a0805b31a80c8","fef13a95de4a4add88defb638e75a8be","538a5b3c9fb64b768c77ead6e51bea93","dfbcc4e277254142b38eaad54f6e2cbb","4c10cc17763e440e9716765ff779e311","4fd58c1caecb40cb94daabff85ba223f","41c5f647a85f44b49391dea16f936655","b5a6bfcd302045a38bc26fd13992faa8","d6f5e24eceb54377a7fb64790938bc66","71d1733050b840a19e5b376a74d96f4e","b65f9b7aac004d20b047b70c88152b00","98db36c13a794f55b060209520b661d5","5d89b9f3504347939a5ee4d26a05c794","6168a21be09548a48ed0219aae6c8f1e","e672018e81a14289af2938b77b991476","cbeb093ad0b9418b861145404a86d8c0","f335ca07a26f40d48af7a457a428ac4a","7f311df905e14418b39fb9685d3740b4","3bccbb39e3fc414695c70cf604cca2db","b31f3781073c4fc18509a5d77b91e5ec","cbee761de0064a398f1338db518a0a12","a4e358ee6cc74c43ba1f7c5f80fe82b2","499ea35d2b3546a580b1b3ce1bbc0534","295bd26e9f104df281c02d9bdc4b61f7","9db42fc695ca4ababc7b360f00a9b4cd","3c715b72b58343cb8663fe9e01b04d2c","140e4be918874b7898018fd1bf14ace9","a4f9f0ec86574f82832f7639f602a532","7124f20347a1474eb0f3c9453715fd52","c953d5379a684f13a12ebf4c07ea46bc","6bb4b288f96b446b969102f4786e4ac5","af620a00ca144b7892da43b12e5b8e16","d1b3091de6c64e3382f7c69c3258b220","c117765157144fb3902dc63594d259e3","4f66b87eb9b6496ab5724d5e76ce8c3e","f3a7f0243284404289b7f410be65c9cc","44577374f7774107b0d1ca9179dfaa10","591586e18c834df29d73f9ec8ad799fa","7b4766790a7f431ca21862f0e829ca9f","84f5b0added846f3b895a28046ed2ffa","d284b2b2c10045e08c40e5e087c01dd4","ac5dfcd0005a46a0bd2ed655c4349f00","61129bc3045447c38014a7ae03a929d1","977408b41e0c4ab996d83c494fb3d25f","0de56cfb8e5c45ccb9b52976648d6727","42f70fad29c14960a99ab2bdc7a0a1ad","382c20a100984b0792e80237cbf035f3","899e281037384efb8df7654c34ecdd17","932acfba13eb4321b13a19965d71de3b","3d4a89318bfb4cd581108bb6d7018a7c","cc6e14db21f044f8aa583568747167ec","8187510be2444207bc233d92882b0d29","73865a80879d4e7899464bf113caf2aa","2d347d4cc94d40fab1f9a1db7d800e0b","910095810c97493582781d9a473ea709","27abb70d43fc4d9e9af7174db108888e","701e9de3c1684f11ae6ec83552c46a45","0f9e993919254e8fb150baff4d947571","6c746513b7784aec9ad83fd12d4e189b","2608ede1a7c645a6afcf174071b46130","5e9c43725ef54b8296c78083069b9ec8","2f564a5dc75741aa84224f372b6142eb","a21cda92fb2d4e019dcfb30c7a619d8a","75306f49d93149b69b3aaa26ce05ce14","204b0710795047bab07667ee9326ad7e","5753baaa29b141ffa8339c2c205e81fd","a3da5fedb591453e964a02d451110466","475ab237956545d9ba690100d7d93b5e","002278dd7a2140d69e91d2fa6ec8f957","f32181a699e54d5eb6f313a92bf24a6b","1e5458aa7187494cba574498daf74c21","f4a0b3f04b8443399461d0861da4bc15","b9bfcb94532d457fbc2d06c4ff6f7f55","935b77eedb4a44a195a72d52d726e98c","f85b2701b97c41dc81522464a24a6773","b69b5465160142dcaf6c8c572a631a23","5036a6453ca74672bbfbfc28957a9f78","d4ceb8b9a9fa4a55ba5323dc79eacf73","996ecb1636db4b238a69ff3db3054bca","2318e00e8b9f4c5da0e68c424a0b12d4","4995fe63de1343a5a2b035bde9a1e1e0","06ba3698f0444d75bd99f12118754ffe","780aa6ff6707436ba55474ef897d1340","2c24a75944044c35b6310f4900df5b61","b3d9f592165b434f8114a11ce25de464"],"text":"\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multicolumn{5}{|c|}{HEMATOLOGY} \\\\\n\\hline ITEM & Grade 1 Toxicity & Grade 2 Toxicity & Grade 3 Toxicity & Grade 4 Toxicity \\\\\n\\hline Hemoglobin & \\(9.5-10.5 gm / Dl\\) & \\(8.0-9.4 gm / Dl\\) & \\(6.5-7.9 gm / Dl\\) & \\(<6.5 gm / Dl\\) \\\\\n\\hline Absolute Neutrophil Count & \\(1000-1500 / mm ^{3}\\) & \\(750-999 / mm ^{3}\\) & \\(500-749 / mm ^{3}\\) & \\(<500 / mm ^{3}\\) \\\\\n\\hline Platelets & \\(75000-99000 / mm ^{3}\\) & \\(50000-74999 / mm ^{3}\\) & \\(20000-49000 / mm ^{3}\\) & \\(<20000 / mm ^{3}\\) \\\\\n\\hline Prothrombin Time (PT) & \\(1.01-1.25 \\times\\) ULN & \\(1.26-1.5 \\times\\) ULN & 1.51-3.0 × ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Activated Partial Thromboplastin (APPT) & 1.01-1.66x ULN & \\(1.67-2.33 \\times\\) ULN & 2.34-3 \\(\\times\\) ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Fibrinogen & 0.75-0.99X LLN & 0.50-0.74 × LL.N & 0.25-0.49 × LLN & \\(<0.25 \\times\\) LLN \\\\\n\\hline Fibrin Split Product & \\(20-40 mcg / ml\\) & \\(41-50 mcg / ml\\) & \\(51-60 mcg / ml\\) & \\(>60 mcg / ml\\) \\\\\n\\hline Methemoglobin & 5-9.9\\% & 10.0-14.9\\% & 15.0-19.9\\% & >20\\% \\\\\n\\hline \\multicolumn{5}{|c|}{LIVER ENZYMES} \\\\\n\\hline AST (SGOT) & \\(1.25-2.5 \\times\\) UL.N & \\(2.6-5 x\\) ULN & 5.1-10x ULN & \\(>10 x ULN\\) \\\\\n\\hline ALT (SGPT) & \\(1.25-2.5 \\times\\) ULN & 2.6-5x ULN & 5.1-10 x ULN & \\(>10 \\times\\) ULN \\\\\n\\hline GGT & 1.25-2.5 × ULN & 1.6-5 x ULN & \\(5.1-10 x\\) ULN & \\(>10 \\times ULN\\) \\\\\n\\hline Alkaline Phosphatase & 125-2.5x ULN & \\(1.6-5 x\\) ULN & \\(5.1-10 x\\) ULN & \\(>10 x\\) ULN \\\\\n\\hline Amylase & \\(1.1-1.5 \\times\\) ULN & \\(1.6-2.0 \\times\\) UL.N & 2.1-5.0x ULN & \\(>5.1 \\times ULN\\) \\\\\n\\hline \\multicolumn{5}{|c|}{CHEMISTRIES} \\\\\n\\hline Hyponatremia & \\(130-135 mEq / L\\) & \\(123-129 mEq / L\\) & \\(116-122 mEq / L\\) & <116 or mental status changes or seizures \\\\\n\\hline Hypernatremia & \\(146-150 mBq / L\\) & \\(151-157 mEq / L\\) & \\(158-165 mEq / L\\). & \\(>165 mEq / L\\) or mental status changes or seizures \\\\\n\\hline Hypokalemia & \\(3.0-3.4 mEq / L\\) & \\(2.5 \\cdot 2.9 mEq / L\\) & \\(2.0-2.4 mEq / L\\) or intensive replacement Rx required or hospitalization required. & \\(<2.0 mEq / L\\) or paresis or ileus or life-threatening arrhythmua \\\\\n\\hline Hyperkalemia & \\(5.6-6.0 mEq / L\\) & \\(6.1-6.5 mEq / L\\) & \\(6.6-7.0 mEq / l\\) & \\(>7.0 mEq / L\\) or life-threatening arrhythmia \\\\\n\\hline Hypoglycemia & \\(55-64 mg / dL\\) & \\(40-54 mg / dL\\) & \\(30-39 mg / dL\\) & \\(<30 mg / dL\\) or mental status changes or coma \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multicolumn{5}{|c|}{HEMATOLOGY} \\\\\n\\hline ITEM & Grade 1 Toxicity & Grade 2 Toxicity & Grade 3 Toxicity & Grade 4 Toxicity \\\\\n\\hline Hemoglobin & \\(9.5-10.5 gm / Dl\\) & \\(8.0-9.4 gm / Dl\\) & \\(6.5-7.9 gm / Dl\\) & \\(<6.5 gm / Dl\\) \\\\\n\\hline Absolute Neutrophil Count & \\(1000-1500 / mm ^{3}\\) & \\(750-999 / mm ^{3}\\) & \\(500-749 / mm ^{3}\\) & \\(<500 / mm ^{3}\\) \\\\\n\\hline Platelets & \\(75000-99000 / mm ^{3}\\) & \\(50000-74999 / mm ^{3}\\) & \\(20000-49000 / mm ^{3}\\) & \\(<20000 / mm ^{3}\\) \\\\\n\\hline Prothrombin Time (PT) & \\(1.01-1.25 \\times\\) ULN & \\(1.26-1.5 \\times\\) ULN & 1.51-3.0 × ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Activated Partial Thromboplastin (APPT) & 1.01-1.66x ULN & \\(1.67-2.33 \\times\\) ULN & 2.34-3 \\(\\times\\) ULN & \\(>3 \\times\\) ULN \\\\\n\\hline Fibrinogen & 0.75-0.99X LLN & 0.50-0.74 × LL.N & 0.25-0.49 × LLN & \\(<0.25 \\times\\) LLN \\\\\n\\hline Fibrin Split Product & \\(20-40 mcg / ml\\) & \\(41-50 mcg / ml\\) & \\(51-60 mcg / ml\\) & \\(>60 mcg / ml\\) \\\\\n\\hline Methemoglobin & 5-9.9\\% & 10.0-14.9\\% & 15.0-19.9\\% & >20\\% \\\\\n\\hline \\multicolumn{5}{|c|}{LIVER ENZYMES} \\\\\n\\hline AST (SGOT) & \\(1.25-2.5 \\times\\) UL.N & \\(2.6-5 x\\) ULN & 5.1-10x ULN & \\(>10 x ULN\\) \\\\\n\\hline ALT (SGPT) & \\(1.25-2.5 \\times\\) ULN & 2.6-5x ULN & 5.1-10 x ULN & \\(>10 \\times\\) ULN \\\\\n\\hline GGT & 1.25-2.5 × ULN & 1.6-5 x ULN & \\(5.1-10 x\\) ULN & \\(>10 \\times ULN\\) \\\\\n\\hline Alkaline Phosphatase & 125-2.5x ULN & \\(1.6-5 x\\) ULN & \\(5.1-10 x\\) ULN & \\(>10 x\\) ULN \\\\\n\\hline Amylase & \\(1.1-1.5 \\times\\) ULN & \\(1.6-2.0 \\times\\) UL.N & 2.1-5.0x ULN & \\(>5.1 \\times ULN\\) \\\\\n\\hline \\multicolumn{5}{|c|}{CHEMISTRIES} \\\\\n\\hline Hyponatremia & \\(130-135 mEq / L\\) & \\(123-129 mEq / L\\) & \\(116-122 mEq / L\\) & <116 or mental status changes or seizures \\\\\n\\hline Hypernatremia & \\(146-150 mBq / L\\) & \\(151-157 mEq / L\\) & \\(158-165 mEq / L\\). & \\(>165 mEq / L\\) or mental status changes or seizures \\\\\n\\hline Hypokalemia & \\(3.0-3.4 mEq / L\\) & \\(2.5 \\cdot 2.9 mEq / L\\) & \\(2.0-2.4 mEq / L\\) or intensive replacement Rx required or hospitalization required. & \\(<2.0 mEq / L\\) or paresis or ileus or life-threatening arrhythmua \\\\\n\\hline Hyperkalemia & \\(5.6-6.0 mEq / L\\) & \\(6.1-6.5 mEq / L\\) & \\(6.6-7.0 mEq / l\\) & \\(>7.0 mEq / L\\) or life-threatening arrhythmia \\\\\n\\hline Hypoglycemia & \\(55-64 mg / dL\\) & \\(40-54 mg / dL\\) & \\(30-39 mg / dL\\) & \\(<30 mg / dL\\) or mental status changes or coma 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Rx required & requires acute Rx; No hospitalization & requires hospitalization \\\\\n\\hline Hypotension & transient orthostatic hypotension, No Rx & symptoms correctable with oral fluids Rx & requires IV fluids, no hospitalization required & requires hospitalization \\\\\n\\hline Pericarditis & minimal effusion & mild/moderate asymptomatic effusion, no Rx & symptomatic effusion: pain; EKG changes & tamponade; pericardiocentesis or surgery required \\\\\n\\hline Hemorrhage, Blood Loss & microscopic/occult & mild, no transfusion & gross blood loss, 1-2 units transfused & massive blood loss; \\(>3\\) units transfused \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multicolumn{5}{|l|}{CHEMISTRIES (continued)} \\\\\n\\hline Hyperglycemia (note if fasting) & \\(116-160 mg / dL\\) & \\(161-250 mg / dL\\) & \\(251.500 mg / dL\\) & \\(>500 mg / dL\\). or ketoacidosis or seizures \\\\\n\\hline Hypocalcemia (corrected for albumin) & \\(8.4-7.8 mg / dL\\) & \\(7.7-7.0 mg / dL\\). & \\(6.9-6.1 mg / dL\\) & \\(<6.1 mg / dL\\) or life threatening arrhythmia or tetany \\\\\n\\hline Hypercalcemia (correct for albumin) & \\(10.6-11.5 mg / dL\\) & \\(11.6-12.5 mg / dL\\) & \\(12.6-13.5 mg / dL\\) & \\(>13.5 mg / dL\\) life-threatening arrhythmia \\\\\n\\hline Hypomagnesemua & \\(1.4-1.2 mEq / L\\) & \\(1.1-0.9 mEq / L\\) & \\(0.8-0.6 mEq / L\\) & \\(<0.6 mEq / L\\) or lifethreatening arrhythmia \\\\\n\\hline Hypophosphatemia & \\(2.0-2.4 mg / dL\\). & \\(1.5-1.9 mg / dL\\) or replacement Rx required & \\(1.0-1.4 mg / dL\\) mtensive Rx or hospitalization required & \\(<1.0 mg / dL\\) or lifethreatening arrhythmia \\\\\n\\hline Hyperbilirubinemia & 1.1-1.5xULN & 1.6-2.5 x ULN & \\(2.6-5 x\\) ULN & > 5xULN \\\\\n\\hline BUN & 1,25-2,5x ulN & 2.6-5 x ULN & \\(5.1-10 \\times\\) ULN & > 10 xulN \\\\\n\\hline Creatinine & \\(1.1 \\times 1.5 \\times\\) ULN & 1.6-3.0x ULN & 3.1-6 x ULN & \\(>6 \\times\\) ULN or required dialysis \\\\\n\\hline \\multicolumn{5}{|c|}{URINALYSIS} \\\\\n\\hline Proteinuria & \\(l +\\) or \\(<0.3 \\%\\) or \\(<3 g / L\\) or \\(200 mg -1 gm\\) loss/day & 2-3+or 0.3-1.0\\% or \\(3-10 g / L 1-2 gm\\) loss/day & \\(4+\\) or \\(>1.0 \\%\\) or \\(>10\\) g/L \\(2-3.5 gm\\) loss/day & nephrotic syndrome or \\(>3.5 gm\\) loss/day \\\\\n\\hline Hematuria & microscopic only & gross, no clots & gross + clots & obstructive or required transfusion \\\\\n\\hline \\multicolumn{5}{|l|}{CARDIAC DYSFUNCTION} \\\\\n\\hline Cardiac Rhythm & & asymptomatic, transient signs, no Rx required & recurrent/persistent; No Rx required & requires treatment \\\\\n\\hline Hypertension & transient inc. \\(>20 mm\\); no Rx & recurrent, chronic, > 20 mm . 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\\multicolumn{5}{|c|}{RESPIRATORY} \\\\\n\\hline Cough & transient- no Rx & treatment associated cough local Rx & uncontrolled & \\\\\n\\hline Bronchospasm, Acute & transient, no Rx \\(<80 \\%-70 \\%\\) FEV \\(_{1}\\) (or peal flow) & requires Rx normalizes with bronchodilator: FEV \\({ }_{1} 50 \\%\\) - 70\\% (or peak Flow) & no normalization with bronchodilator: \\(FEV _{1}\\) 25\\% - 50\\% (or peak flow retractions) & cyanosis \\(FEV _{1}\\) <25\\% (or peak flow) or intubated \\\\\n\\hline \\multicolumn{5}{|l|}{GASTROINTESTINAL} \\\\\n\\hline Stomatitis & mild discomfort, no limits on activity & some limits on eating/drinking & eating/talking very limited & requires IV fluids \\\\\n\\hline Nausea & mild discomfort, maintains reasonable intake & moderate disconfort; intake decreased significantly; some activity limited & severe discomfort, no significant intake: activities limited & minimal fluid intake \\\\\n\\hline Vomiting & transient emesis & occasional/moderate vomiting & orthostatic hypotension or IV fluids required & hypotensive shock or hospitalization required for IV fluid therapy \\\\\n\\hline Constipation & mild & moderate & severe & distensions w/vomiting \\\\\n\\hline Diarrhea & transient 3-4 loose stools/day & 5-7 loose stools/day & orthostatic hypotension or >7 loose stools/day or required IV fluids & hypotensive shock or hospitalization for IV fluid therapy required \\\\\n\\hline \\multicolumn{5}{|l|}{NEURO \\& NEUROMUSCULAR} \\\\\n\\hline Neuro-Cerebellar & slight incoordination dysdiadochokinesis & intention tremor, dysmetria, slurred speech; nystagmus & locomotor ataxia & incapacitated \\\\\n\\hline Mood & mild anxiety or depression & moderate anxiety or depression and therapy required & severe anxiety or depression or mania; needs assistance & acute psychosis: incapacitated, requires hospitalization \\\\\n\\hline Neuro Control (ADL = activities of daily living) & mild difficulty concentrating; no Rx; mild confusion/agitation: ADL unaffected & moderate confusion/agitation some limitation of ADL, minimal Rx & severe confusion/agitation needs assistance for ADL; therapy required & toxic psychosis; hospitalization \\\\\n\\hline Muscle Strength & subjective weakness no objective symptoms/ signs & mild objective signs/symptoms no decrease in function & objective weakness function limited & paralysis \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multicolumn{5}{|c|}{RESPIRATORY} \\\\\n\\hline Cough & transient- no Rx & treatment associated cough local Rx & uncontrolled & \\\\\n\\hline Bronchospasm, Acute & transient, no Rx \\(<80 \\%-70 \\%\\) FEV \\(_{1}\\) (or peal flow) & requires Rx normalizes with bronchodilator: FEV \\({ }_{1} 50 \\%\\) - 70\\% (or peak Flow) & no normalization with bronchodilator: \\(FEV _{1}\\) 25\\% - 50\\% (or peak flow retractions) & cyanosis \\(FEV _{1}\\) <25\\% (or peak flow) or intubated \\\\\n\\hline \\multicolumn{5}{|l|}{GASTROINTESTINAL} 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