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Anesthetic properties are likely mediated by depression of NMDA receptor neuro-","text_display":" anesthetics. 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The management of newborn","text_display":" pathways are present in the fetus as early as 22 weeks of gestation \\({ }^{2}\\). The management of newborn","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[192,1352],[1802,1352],[1802,1400],[192,1400]],"region":{"top_left_x":191,"top_left_y":1352,"width":1612,"height":49},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d6326551e0a446f2a0b6a2505be182bc","type":"text","conversion_output":true,"text":"pain by pharmacological or non-pharmacological means was the subject of a consensus by the","text_display":" pain by pharmacological or non-pharmacological means was the subject of a consensus by the","confidence":0.9926791191101074,"confidence_rate":0.999922657622139},{"cnt":[[192,1412],[1661,1412],[1661,1464],[192,1464]],"region":{"top_left_x":191,"top_left_y":1411,"width":1470,"height":54},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"33eb274806f649e1ab549d9aca292b74","type":"text","conversion_output":true,"text":"American Academy of Pediatrics and the Canadian Pediatric Society in \\(2000{ }^{3}\\). A large","text_display":" American Academy of Pediatrics and the Canadian Pediatric Society in \\(2000{ }^{3}\\). A large","confidence":0.7455166604572696,"confidence_rate":0.9970379531488917},{"cnt":[[192,1480],[1857,1480],[1857,1528],[192,1528]],"region":{"top_left_x":191,"top_left_y":1480,"width":1667,"height":49},"line":19,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"bfe5c7c4064141d6b7c7a39b9c53aed3","type":"text","conversion_output":true,"text":"observational study conducted in the Paris region in 2005-2006 reports that the median number of","text_display":" observational study conducted in the Paris region in 2005-2006 reports that the median number of","confidence":0.9990236759185791,"confidence_rate":0.9999903287497746},{"cnt":[[192,1544],[1761,1544],[1761,1597],[192,1597]],"region":{"top_left_x":191,"top_left_y":1544,"width":1571,"height":53},"line":20,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"6b051a1b94d54bc1912b5172b137ab21","type":"text","conversion_output":true,"text":"painful procedures in neonatal intensive care units is 16 per child per day of hospitalization \\({ }^{4}\\).","text_display":" painful procedures in neonatal intensive care units is 16 per child per day of hospitalization \\({ }^{4}\\).","confidence":1,"confidence_rate":1},{"cnt":[[192,1613],[1848,1613],[1848,1661],[192,1661]],"region":{"top_left_x":191,"top_left_y":1612,"width":1658,"height":49},"line":21,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2daa0e43984c4603a1c302a8429d7235","type":"text","conversion_output":true,"text":"Beyond its ethically obvious nature, the management of newborn pain is important at many levels.","text_display":" Beyond its ethically obvious nature, the management of newborn pain is important at many levels.","confidence":1,"confidence_rate":1},{"cnt":[[192,1681],[1738,1681],[1738,1727],[192,1727]],"region":{"top_left_x":191,"top_left_y":1681,"width":1548,"height":46},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"16d6180073dd4ebda580c997bcfa7e8d","type":"text","conversion_output":true,"text":"Repeated exposure to pain during the neonatal period has adverse consequences on brain","text_display":" Repeated exposure to pain during the neonatal period has adverse consequences on brain","confidence":1,"confidence_rate":1},{"cnt":[[192,1741],[1816,1741],[1816,1793],[192,1793]],"region":{"top_left_x":191,"top_left_y":1740,"width":1626,"height":54},"line":23,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"3bbccfa1b25d40c9863ce663b58b1d19","type":"text","conversion_output":true,"text":"development \\({ }^{5}\\). 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In addition, laryngoscopy deforms the larynx and upper airways","text_display":" intraventricular hemorrhage \\({ }^{16}\\). In addition, laryngoscopy deforms the larynx and upper airways","confidence":0.97412109375,"confidence_rate":0.9997616678889252},{"cnt":[[192,281],[1866,281],[1866,331],[192,331]],"region":{"top_left_x":191,"top_left_y":280,"width":1676,"height":52},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e7cf380fa36c40d38c02e30d353f9a9a","type":"text","conversion_output":true,"text":"causing activation of the sympathetic and parasympathetic system responsible for bradycardia and","text_display":" causing activation of the sympathetic and parasympathetic system responsible for bradycardia and","confidence":1,"confidence_rate":1},{"cnt":[[192,338],[806,338],[806,395],[192,395]],"region":{"top_left_x":191,"top_left_y":338,"width":616,"height":58},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9abe727bfe8f410e986587fccefa06c8","type":"text","conversion_output":true,"text":"increased intra-thoracic pressure \\({ }^{17}\\).","text_display":" increased intra-thoracic pressure \\({ }^{17}\\).","confidence":0.986328125,"confidence_rate":0.9997402941866749},{"cnt":[[315,411],[1839,411],[1839,461],[315,461]],"region":{"top_left_x":315,"top_left_y":411,"width":1524,"height":51},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"752def26b83548c291777a99b4cbd217","type":"text","conversion_output":true,"text":"Reasons for not using analgesia may include lack of familiarity with premedication, fear of","text_display":"\n\nReasons for not using analgesia may include lack of familiarity with premedication, fear of","confidence":1,"confidence_rate":1},{"cnt":[[192,477],[1866,477],[1866,528],[192,528]],"region":{"top_left_x":191,"top_left_y":477,"width":1676,"height":51},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a92ccedc0ef94b1dabc841eaf26421a1","type":"text","conversion_output":true,"text":"adverse effects, lack of sufficient evidence of efficacy, or lack of consensus on the optimal regimen","text_display":" adverse effects, lack of sufficient evidence of efficacy, or lack of consensus on the optimal regimen","confidence":1,"confidence_rate":1},{"cnt":[[192,544],[1761,544],[1761,592],[192,592]],"region":{"top_left_x":191,"top_left_y":543,"width":1571,"height":49},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"54251719d0584ca19f9d099d6b6aa032","type":"text","conversion_output":true,"text":"of premedication. Several therapeutic classes have been evaluated for premedication before","text_display":" of premedication. Several therapeutic classes have been evaluated for premedication before","confidence":1,"confidence_rate":1},{"cnt":[[192,603],[1789,603],[1789,660],[192,660]],"region":{"top_left_x":191,"top_left_y":603,"width":1598,"height":58},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8a19ad3390014ca681749332219c2bc8","type":"text","conversion_output":true,"text":"intubation and have been the subject of a recent comprehensive review \\({ }^{18}\\). Barbiturates do not","text_display":" intubation and have been the subject of a recent comprehensive review \\({ }^{18}\\). Barbiturates do not","confidence":0.99755859375,"confidence_rate":0.9999775746428119},{"cnt":[[192,667],[1750,667],[1750,724],[192,724]],"region":{"top_left_x":191,"top_left_y":667,"width":1559,"height":58},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"fc0f900776194365978dc992d590fcff","type":"text","conversion_output":true,"text":"diminish the occurrence of desaturations \\({ }^{17,19}\\). Midazolam seems dangerous if used alone \\({ }^{20}\\).","text_display":" diminish the occurrence of desaturations \\({ }^{17,19}\\). Midazolam seems dangerous if used alone \\({ }^{20}\\).","confidence":0.994631290435791,"confidence_rate":0.9999543809314726},{"cnt":[[192,736],[1843,736],[1843,788],[192,788]],"region":{"top_left_x":191,"top_left_y":735,"width":1653,"height":54},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b4bb32d2aeea4778809caa5c8aa0f764","type":"text","conversion_output":true,"text":"Opioids used without a neuromuscular blockerare associated with frequent desaturations \\({ }^{21,22}\\). On","text_display":" Opioids used without a neuromuscular blockerare associated with frequent desaturations \\({ }^{21,22}\\). On","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[192,809],[1853,809],[1853,854],[192,854]],"region":{"top_left_x":191,"top_left_y":808,"width":1662,"height":47},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"96802f7de1904ba2855f6e29b3251fba","type":"text","conversion_output":true,"text":"the other hand, the combination of opioid and a neuromuscular blocker improves the conditions of","text_display":" the other hand, the combination of opioid and a neuromuscular blocker improves the conditions of","confidence":1,"confidence_rate":1},{"cnt":[[192,866],[1780,866],[1780,921],[192,921]],"region":{"top_left_x":191,"top_left_y":865,"width":1589,"height":56},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a69467c90d954bce8f01bf72afbeaa14","type":"text","conversion_output":true,"text":"intubation \\({ }^{22}\\). This opioid+neuromuscular blocker combination is therefore considered the gold","text_display":" intubation \\({ }^{22}\\). This opioid+neuromuscular blocker combination is therefore considered the gold","confidence":0.9990236759185791,"confidence_rate":0.9999910385631244},{"cnt":[[192,932],[982,932],[982,989],[192,989]],"region":{"top_left_x":191,"top_left_y":932,"width":792,"height":58},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a6ff215093b9491d867d2d8637601698","type":"text","conversion_output":true,"text":"standard of premedication before intubation \\({ }^{23}\\).","text_display":" standard of premedication before intubation \\({ }^{23}\\).","confidence":1,"confidence_rate":1},{"cnt":[[315,1005],[1750,1005],[1750,1053],[315,1053]],"region":{"top_left_x":315,"top_left_y":1005,"width":1435,"height":49},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"655b0b9c24f94c76a1ad692f0b69d23c","type":"text","conversion_output":true,"text":"Propofol is a diisopropylphenol which has many theoretical advantages. Its activity is","text_display":"\n\nPropofol is a diisopropylphenol which has many theoretical advantages. Its activity is","confidence":1,"confidence_rate":1},{"cnt":[[192,1069],[1848,1069],[1848,1117],[192,1117]],"region":{"top_left_x":191,"top_left_y":1069,"width":1658,"height":49},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b193063b329448a8b65a2adf4dacd619","type":"text","conversion_output":true,"text":"observed in less than a minute after intravenous administration. The duration of action is brief, the","text_display":" observed in less than a minute after intravenous administration. The duration of action is brief, the","confidence":1,"confidence_rate":1},{"cnt":[[192,1133],[1855,1133],[1855,1186],[192,1186]],"region":{"top_left_x":191,"top_left_y":1133,"width":1664,"height":53},"line":16,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f23b5e581ee546a380f6cce80bd5cbe3","type":"text","conversion_output":true,"text":"half-life in adults is 1.8 to 4.1 minutes \\({ }^{24}\\). The preparation of this drug is fast and easy because it is","text_display":" half-life in adults is 1.8 to 4.1 minutes \\({ }^{24}\\). The preparation of this drug is fast and easy because it is","confidence":0.99951171875,"confidence_rate":0.9999961543341811},{"cnt":[[192,1202],[1862,1202],[1862,1250],[192,1250]],"region":{"top_left_x":191,"top_left_y":1201,"width":1671,"height":49},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"dde59a3677544899ba766f62a9ecdedd","type":"text","conversion_output":true,"text":"not necessary to dilute it, which decreases the risk of error. This drugcan be used alone because it","text_display":" not necessary to dilute it, which decreases the risk of error. This drugcan be used alone because it","confidence":0.9951171875,"confidence_rate":0.9999533842067715},{"cnt":[[192,1261],[1869,1261],[1869,1318],[192,1318]],"region":{"top_left_x":191,"top_left_y":1260,"width":1678,"height":59},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"11ed1ba326c94e418311be787be70e64","type":"text","conversion_output":true,"text":"has no vagolytic action. It decreases the pharyngeal reflex and muscle tone facilitating intubation \\({ }^{25}\\)","text_display":" has no vagolytic action. It decreases the pharyngeal reflex and muscle tone facilitating intubation \\({ }^{25}\\)","confidence":0.998046875,"confidence_rate":0.9999826989564276},{"cnt":[[192,1334],[1702,1334],[1702,1382],[192,1382]],"region":{"top_left_x":191,"top_left_y":1334,"width":1511,"height":49},"line":19,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"aea5529903c34ad5a5a977f8cb6b0d98","type":"text","conversion_output":true,"text":"and allows the maintenance of spontaneous breathing. Although it is not an analgesic, its","text_display":" and allows the maintenance of spontaneous breathing. Although it is not an analgesic, its","confidence":1,"confidence_rate":1},{"cnt":[[192,1400],[1871,1400],[1871,1448],[192,1448]],"region":{"top_left_x":191,"top_left_y":1400,"width":1680,"height":49},"line":20,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"fbb3b798437a46038b8d5a58a3a69cbb","type":"text","conversion_output":true,"text":"effectiveness has been proven in many studies in children. It is commonly used as a premedication","text_display":" effectiveness has been proven in many studies in children. It is commonly used as a premedication","confidence":1,"confidence_rate":1},{"cnt":[[192,1457],[1821,1457],[1821,1512],[192,1512]],"region":{"top_left_x":191,"top_left_y":1457,"width":1630,"height":56},"line":21,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b69ccf47b3dc4b818222395a001c50da","type":"text","conversion_output":true,"text":"for bronchial \\({ }^{26}\\) or digestive \\({ }^{27}\\) fibroscopy in children. Propofol has also been shown to be effective","text_display":" for bronchial \\({ }^{26}\\) or digestive \\({ }^{27}\\) fibroscopy in children. Propofol has also been shown to be effective","confidence":1,"confidence_rate":1},{"cnt":[[192,1531],[1821,1531],[1821,1579],[192,1579]],"region":{"top_left_x":191,"top_left_y":1530,"width":1630,"height":49},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0690fd2986114a548957341e1718a9c4","type":"text","conversion_output":true,"text":"for difficult intubations, for intubation in patients with vigil coma and for insertion of laryngeal and","text_display":" for difficult intubations, for intubation in patients with vigil coma and for insertion of laryngeal and","confidence":1,"confidence_rate":1},{"cnt":[[192,1590],[578,1590],[578,1647],[192,1647]],"region":{"top_left_x":191,"top_left_y":1589,"width":387,"height":59},"line":23,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0ceb8c63cded47d682fb986945697545","type":"text","conversion_output":true,"text":"pharyngeal masks \\({ }^{28,29}\\).","text_display":" pharyngeal masks \\({ }^{28,29}\\).","confidence":1,"confidence_rate":1},{"cnt":[[315,1665],[1793,1665],[1793,1711],[315,1711]],"region":{"top_left_x":315,"top_left_y":1665,"width":1479,"height":46},"line":24,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"bdd794c972224265b7b4337962693490","type":"text","conversion_output":true,"text":"The use of propofol is common in adults and children, in intensive care and anesthesia.","text_display":"\n\nThe use of propofol is common in adults and children, in intensive care and anesthesia.","confidence":1,"confidence_rate":1},{"cnt":[[192,1732],[1832,1732],[1832,1780],[192,1780]],"region":{"top_left_x":191,"top_left_y":1731,"width":1642,"height":49},"line":25,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"888f58d6802144d4bbeadbecbc2e8501","type":"text","conversion_output":true,"text":"Reported adverse reactions of propofol are mild injection pain and systemic hypotension. From a","text_display":" Reported adverse reactions of propofol are mild injection pain and systemic hypotension. From a","confidence":1,"confidence_rate":1},{"cnt":[[192,1796],[1802,1796],[1802,1843],[192,1843]],"region":{"top_left_x":191,"top_left_y":1795,"width":1612,"height":49},"line":26,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"34822d9fa8244c33b1628724145da5fc","type":"text","conversion_output":true,"text":"hemodynamic point of view, propofol decreases cardiac pre-load and post-load that can lead to","text_display":" hemodynamic point of view, propofol decreases cardiac pre-load and post-load that can lead to","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[192,1855],[1866,1855],[1866,1912],[192,1912]],"region":{"top_left_x":191,"top_left_y":1854,"width":1676,"height":59},"line":27,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"dbc5b0b60b914f43a304948e3b655a2b","type":"text","conversion_output":true,"text":"systemic hypotension due to a decrease in sympathetic tone and vascular resistance \\({ }^{30}\\) without any","text_display":" systemic hypotension due to a decrease in sympathetic tone and vascular resistance \\({ }^{30}\\) without any","confidence":1,"confidence_rate":1},{"cnt":[[192,1923],[1821,1923],[1821,1976],[192,1976]],"region":{"top_left_x":191,"top_left_y":1923,"width":1630,"height":53},"line":28,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"3eadde873f3b40d6ab79b6c895433101","type":"text","conversion_output":true,"text":"change in myocardial contractility \\({ }^{31}\\). In most cases, hypotension is brief without requiring volume","text_display":" change in myocardial contractility \\({ }^{31}\\). In most cases, hypotension is brief without requiring volume","confidence":1,"confidence_rate":1},{"cnt":[[192,1987],[1871,1987],[1871,2042],[192,2042]],"region":{"top_left_x":191,"top_left_y":1987,"width":1680,"height":56},"line":29,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"838dccf4d7334442a76018b558329e4f","type":"text","conversion_output":true,"text":"expansion \\({ }^{32}\\). In the respiratory system, it has been shown that propofol can reduce the diameter of","text_display":" expansion \\({ }^{32}\\). In the respiratory system, it has been shown that propofol can reduce the diameter of","confidence":1,"confidence_rate":1},{"cnt":[[192,2051],[1871,2051],[1871,2108],[192,2108]],"region":{"top_left_x":191,"top_left_y":2051,"width":1680,"height":58},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"5a0d3e055f21482f868f8b65d25bb1fa","type":"text","conversion_output":true,"text":"the airways; this effect is completely reversible with continuous positive airway ventilation \\({ }^{33}\\). In less","text_display":" the airways; this effect is completely reversible with continuous positive airway ventilation \\({ }^{33}\\). In less","confidence":1,"confidence_rate":1},{"cnt":[[192,2124],[1780,2124],[1780,2172],[192,2172]],"region":{"top_left_x":191,"top_left_y":2124,"width":1589,"height":49},"line":31,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c8c6c4054c96490b82dde1a51c746b5f","type":"text","conversion_output":true,"text":"than \\(2 \\%\\) of children undergoing endoscopy of the upper airway spontaneous ventilation under","text_display":" than \\(2 \\%\\) of children undergoing endoscopy of the upper airway spontaneous ventilation under","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[192,2184],[1871,2184],[1871,2239],[192,2239]],"region":{"top_left_x":191,"top_left_y":2183,"width":1680,"height":56},"line":32,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"dbd34b3866014cb0bd1e7ae0abe48e47","type":"text","conversion_output":true,"text":"propofol, spontaneously resolving episodes of desaturation have been reported \\({ }^{34}\\). Only continuous","text_display":" propofol, spontaneously resolving episodes of desaturation have been reported \\({ }^{34}\\). Only continuous","confidence":1,"confidence_rate":1},{"cnt":[[192,2257],[1839,2257],[1839,2305],[192,2305]],"region":{"top_left_x":191,"top_left_y":2256,"width":1648,"height":49},"line":33,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"06433d9387eb454882c8e6fcb768bb66","type":"text","conversion_output":true,"text":"intravenous infusion of propofol at a dose greater than \\(5 mg / kg / h\\) has been associated in adults","text_display":" intravenous infusion of propofol at a dose greater than \\(5 mg / kg / h\\) has been associated in adults","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[192,2323],[1656,2323],[1656,2369],[192,2369]],"region":{"top_left_x":191,"top_left_y":2323,"width":1466,"height":46},"line":34,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1beed63ff7354182a615e668849d9171","type":"text","conversion_output":true,"text":"and children with severe complications associating zinc deficiency, metabolic acidosis,","text_display":" and children with severe complications associating zinc deficiency, metabolic acidosis,","confidence":1,"confidence_rate":1},{"cnt":[[192,2380],[1745,2380],[1745,2437],[192,2437]],"region":{"top_left_x":191,"top_left_y":2380,"width":1555,"height":58},"line":35,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"26145dc63de1492fbf57224920c4a1b3","type":"text","conversion_output":true,"text":"rhabdomyolysis, hyperkalemia and renal failure that may lead to deaths \\({ }^{35}\\). Finally, maternal","text_display":" rhabdomyolysis, hyperkalemia and renal failure that may lead to deaths \\({ }^{35}\\). Finally, maternal","confidence":1,"confidence_rate":1},{"cnt":[[192,2453],[1775,2453],[1775,2501],[192,2501]],"region":{"top_left_x":191,"top_left_y":2453,"width":1584,"height":49},"line":36,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"341f853dc08f4018a25486c8ee8139d8","type":"text","conversion_output":true,"text":"anesthesia with propofol for caesarean sections does not significantly alter the Apgar score in","text_display":" anesthesia with propofol for caesarean sections does not significantly alter the Apgar score in","confidence":1,"confidence_rate":1},{"cnt":[[192,2513],[1094,2513],[1094,2570],[192,2570]],"region":{"top_left_x":191,"top_left_y":2512,"width":904,"height":58},"line":37,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"41a135e3361f4c5db54e044be7f175e2","type":"text","conversion_output":true,"text":"neonates compared to other analgesic protocols \\({ }^{36,37}\\).","text_display":" neonates compared to other analgesic protocols \\({ }^{36,37}\\).","confidence":1,"confidence_rate":1},{"cnt":[[1846,2755],[1878,2755],[1878,2794],[1846,2794]],"region":{"top_left_x":1845,"top_left_y":2754,"width":33,"height":40},"line":38,"column":0,"font_size":23,"is_printed":true,"is_handwritten":false,"id":"2c3dd73318a24ca5b1feaff9d41aeb23","type":"page_info","conversion_output":false,"text":"ᄃ","text_display":"","confidence":0.6151721477508545,"confidence_rate":0.922216264670465}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-06","page":6,"lines":[{"cnt":[[315,148],[1775,148],[1775,196],[315,196]],"region":{"top_left_x":315,"top_left_y":148,"width":1460,"height":49},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"fd1e0620e2e947569860739278db197e","type":"text","conversion_output":true,"text":"Several animal studies have been conducted on the possible neurotoxicity of propofol.","text_display":"\n\nSeveral animal studies have been conducted on the possible neurotoxicity of propofol.","confidence":1,"confidence_rate":1},{"cnt":[[192,215],[1757,215],[1757,263],[192,263]],"region":{"top_left_x":191,"top_left_y":214,"width":1566,"height":49},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"cfc0b4e390fb4204917b70917b0d9465","type":"text","conversion_output":true,"text":"Indeed, propofol positively modulates the inhibitory function of GABA (gamma-amino-butyric","text_display":" Indeed, propofol positively modulates the inhibitory function of GABA (gamma-amino-butyric","confidence":1,"confidence_rate":1},{"cnt":[[192,279],[1862,279],[1862,331],[192,331]],"region":{"top_left_x":191,"top_left_y":278,"width":1671,"height":54},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c606ffac4e814911aa7a05354321ee73","type":"text","conversion_output":true,"text":"acid)neurotransmitters causing a GABA accumulation by inhibition of reuptake and is an NMDA (N","text_display":" acid)neurotransmitters causing a GABA accumulation by inhibition of reuptake and is an NMDA (N","confidence":1,"confidence_rate":1},{"cnt":[[192,343],[1871,343],[1871,395],[192,395]],"region":{"top_left_x":191,"top_left_y":342,"width":1680,"height":54},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"aa2d297d1dd24d4f882dcd64cabbafe0","type":"text","conversion_output":true,"text":"methyl D aspartate) receptor antagonist. In murine models, NMDA antagonists can induce massive","text_display":" methyl D aspartate) receptor antagonist. In murine models, NMDA antagonists can induce massive","confidence":1,"confidence_rate":1},{"cnt":[[192,407],[1661,407],[1661,461],[192,461]],"region":{"top_left_x":191,"top_left_y":406,"width":1470,"height":56},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"203a1d30e297421e8e7a02f4d52048b2","type":"text","conversion_output":true,"text":"neurodegeneration by apoptosis \\({ }^{38}\\). However, these events are dependent on the dose","text_display":" neurodegeneration by apoptosis \\({ }^{38}\\). However, these events are dependent on the dose","confidence":1,"confidence_rate":1},{"cnt":[[192,477],[1821,477],[1821,528],[192,528]],"region":{"top_left_x":191,"top_left_y":477,"width":1630,"height":51},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ac3707d752634251b71197b6e539f90a","type":"text","conversion_output":true,"text":"administered, the chosen injection schedule (single dose or continuous infusion), the duration of","text_display":" administered, the chosen injection schedule (single dose or continuous infusion), the duration of","confidence":1,"confidence_rate":1},{"cnt":[[192,539],[1816,539],[1816,592],[192,592]],"region":{"top_left_x":191,"top_left_y":539,"width":1626,"height":53},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8c9758918e0241818ff0847ec626f722","type":"text","conversion_output":true,"text":"exposure, stage of development and other anesthetic agents administered simultaneously \\({ }^{39}\\). Al-","text_display":" exposure, stage of development and other anesthetic agents administered simultaneously \\({ }^{39}\\). Al","confidence":1,"confidence_rate":1},{"cnt":[[192,612],[1766,612],[1766,660],[192,660]],"region":{"top_left_x":191,"top_left_y":612,"width":1575,"height":49},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1c8fe57d7078460babbe76bd9d88d31d","type":"text","conversion_output":true,"text":"Jadhari et al. in a dose-response study showed that exposure of neuronal growth cones from","text_display":"Jadhari et al. in a dose-response study showed that exposure of neuronal growth cones from","confidence":1,"confidence_rate":1},{"cnt":[[192,676],[1859,676],[1859,724],[192,724]],"region":{"top_left_x":191,"top_left_y":676,"width":1669,"height":49},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2c0d2115229245aaa312c6bbd4313361","type":"text","conversion_output":true,"text":"chicken embryos resulted in collapse of these embryos, which was reversible if the dose used was","text_display":" chicken embryos resulted in collapse of these embryos, which was reversible if the dose used was","confidence":1,"confidence_rate":1},{"cnt":[[192,736],[1812,736],[1812,788],[192,788]],"region":{"top_left_x":191,"top_left_y":735,"width":1621,"height":54},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8e0aea8ed73e4f90ab351363369abc09","type":"text","conversion_output":true,"text":"low and the exposure time was short \\({ }^{39}\\). The toxic doses used in this study are much higher than","text_display":" low and the exposure time was short \\({ }^{39}\\). The toxic doses used in this study are much higher than","confidence":0.9970703125,"confidence_rate":0.9999735680300983},{"cnt":[[192,809],[1869,809],[1869,857],[192,857]],"region":{"top_left_x":191,"top_left_y":808,"width":1678,"height":49},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"5adb8edede2f499f87c0ae0fb6b9ee9c","type":"text","conversion_output":true,"text":"the doses used in humans. Vutskits et al identified an impairment of dendritic growth of rat neurons","text_display":" the doses used in humans. Vutskits et al identified an impairment of dendritic growth of rat neurons","confidence":1,"confidence_rate":1},{"cnt":[[192,868],[1729,868],[1729,921],[192,921]],"region":{"top_left_x":191,"top_left_y":868,"width":1539,"height":53},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7ba0622f95814033b99f30532d08f252","type":"text","conversion_output":true,"text":"in vitro at doses considered clinically relevant \\({ }^{40}\\). In contrast, propofol has beneficial effects","text_display":" in vitro at doses considered clinically relevant \\({ }^{40}\\). In contrast, propofol has beneficial effects","confidence":0.9990234375,"confidence_rate":0.9999913536688149},{"cnt":[[192,941],[1789,941],[1789,989],[192,989]],"region":{"top_left_x":191,"top_left_y":941,"width":1598,"height":49},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"29e8c9f6d0c648a4a6d45d92d791be1c","type":"text","conversion_output":true,"text":"described by its antioxidant properties in the adult animal where a model of cerebral ischemia-","text_display":" described by its antioxidant properties in the adult animal where a model of cerebral ischemia","confidence":1,"confidence_rate":1},{"cnt":[[192,998],[1807,998],[1807,1053],[192,1053]],"region":{"top_left_x":191,"top_left_y":998,"width":1616,"height":56},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"50fc67928e72474fbd23fe2ef1dadac9","type":"text","conversion_output":true,"text":"reperfusion is observed to decrease neuronal apoptosis \\({ }^{41}\\). The mechanism of action involves a","text_display":"reperfusion is observed to decrease neuronal apoptosis \\({ }^{41}\\). The mechanism of action involves a","confidence":1,"confidence_rate":1},{"cnt":[[192,1065],[1741,1065],[1741,1117],[192,1117]],"region":{"top_left_x":191,"top_left_y":1064,"width":1550,"height":54},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b5bf7a5c6d4542d0a9056317aa8a5f09","type":"text","conversion_output":true,"text":"decrease in lipid peroxidation \\({ }^{42}\\) and a decrease in the amount of free radicals \\({ }^{43}\\). In animals,","text_display":" decrease in lipid peroxidation \\({ }^{42}\\) and a decrease in the amount of free radicals \\({ }^{43}\\). In animals,","confidence":1,"confidence_rate":1},{"cnt":[[192,1138],[1843,1138],[1843,1186],[192,1186]],"region":{"top_left_x":191,"top_left_y":1137,"width":1653,"height":49},"line":16,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d59bff71660140619f09586ba581ba42","type":"text","conversion_output":true,"text":"propofol also has immunomodulatory effects. There is a decrease in mortality in anesthetized rats","text_display":" propofol also has immunomodulatory effects. There is a decrease in mortality in anesthetized rats","confidence":1,"confidence_rate":1},{"cnt":[[192,1197],[1830,1197],[1830,1250],[192,1250]],"region":{"top_left_x":191,"top_left_y":1197,"width":1639,"height":53},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"38a4c72b97034dd4b6402f35b3f2751e","type":"text","conversion_output":true,"text":"after induction of septic shock by bacterial endotoxin \\({ }^{44}\\). Propofol decreases the synthesis of pro-","text_display":" after induction of septic shock by bacterial endotoxin \\({ }^{44}\\). Propofol decreases the synthesis of pro","confidence":0.99560546875,"confidence_rate":0.9999617032065153},{"cnt":[[192,1261],[1793,1261],[1793,1318],[192,1318]],"region":{"top_left_x":191,"top_left_y":1260,"width":1603,"height":59},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ed990bceede64d42a6a01c639bc8ff1d","type":"text","conversion_output":true,"text":"inflammatory cytokines (TNFa and IL-6) in vivo and in vitro \\({ }^{45}\\). It alters the immune functions of","text_display":"inflammatory cytokines (TNFa and IL-6) in vivo and in vitro \\({ }^{45}\\). It alters the immune functions of","confidence":0.755859375,"confidence_rate":0.9975260746609765},{"cnt":[[192,1327],[1766,1327],[1766,1382],[192,1382]],"region":{"top_left_x":191,"top_left_y":1327,"width":1575,"height":56},"line":19,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"36e8e1e3eb614d65ab9282842bb4a7e0","type":"text","conversion_output":true,"text":"monocytes and polymorphonuclear neutrophils \\({ }^{46}\\). It has a protective effect on the lungs after","text_display":" monocytes and polymorphonuclear neutrophils \\({ }^{46}\\). It has a protective effect on the lungs after","confidence":1,"confidence_rate":1},{"cnt":[[192,1393],[1037,1393],[1037,1451],[192,1451]],"region":{"top_left_x":191,"top_left_y":1393,"width":847,"height":58},"line":20,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"da449ef8b69744eb8043ddad17973823","type":"text","conversion_output":true,"text":"experimental induction of ARDS with oleic acid \\({ }^{47}\\).","text_display":" experimental induction of ARDS with oleic acid \\({ }^{47}\\).","confidence":1,"confidence_rate":1},{"cnt":[[315,1467],[1775,1467],[1775,1515],[315,1515]],"region":{"top_left_x":315,"top_left_y":1466,"width":1460,"height":49},"line":21,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"11e68756a84b4c6aa78ace5d597d3b67","type":"text","conversion_output":true,"text":"The interpretation of such experimental results is delicate and experts recommend the","text_display":"\n\nThe interpretation of such experimental results is delicate and experts recommend the","confidence":1,"confidence_rate":1},{"cnt":[[192,1526],[1793,1526],[1793,1579],[192,1579]],"region":{"top_left_x":191,"top_left_y":1525,"width":1603,"height":54},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0059b690ded14e568978b709c76a8e0e","type":"text","conversion_output":true,"text":"utmost caution in the transposition of animal data to humans \\({ }^{48}\\). All families of anesthetic drugs","text_display":" utmost caution in the transposition of animal data to humans \\({ }^{48}\\). All families of anesthetic drugs","confidence":1,"confidence_rate":1},{"cnt":[[192,1599],[1750,1599],[1750,1647],[192,1647]],"region":{"top_left_x":191,"top_left_y":1599,"width":1559,"height":49},"line":23,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b10c642fcb134705b88859ea12b66e1d","type":"text","conversion_output":true,"text":"(opioids, benzodiazepines, GABA agonists, NMDA antagonists) have been implicated in the","text_display":" (opioids, benzodiazepines, GABA agonists, NMDA antagonists) have been implicated in the","confidence":1,"confidence_rate":1},{"cnt":[[192,1658],[1825,1658],[1825,1711],[192,1711]],"region":{"top_left_x":191,"top_left_y":1658,"width":1635,"height":53},"line":24,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"93739ac501d24556b1155b93a112fc32","type":"text","conversion_output":true,"text":"development of brain development disorders \\({ }^{48,49}\\). However, the fight against pain must remain a","text_display":" development of brain development disorders \\({ }^{48,49}\\). However, the fight against pain must remain a","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[192,1732],[1743,1732],[1743,1780],[192,1780]],"region":{"top_left_x":191,"top_left_y":1731,"width":1552,"height":49},"line":25,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"34d0e80eee6d44b1bbbe05b5e94453d0","type":"text","conversion_output":true,"text":"priority in Neonatology while ensuring a rigorous and long-term evaluation of new practices.","text_display":" priority in Neonatology while ensuring a rigorous and long-term evaluation of new practices.","confidence":1,"confidence_rate":1},{"cnt":[[315,1859],[1807,1859],[1807,1910],[315,1910]],"region":{"top_left_x":315,"top_left_y":1859,"width":1492,"height":51},"line":26,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"247e65ff4abf4cbf94148debcc22ac66","type":"text","conversion_output":true,"text":"Researchers in San Diego and Dartmouth have previously studied the value of adding a","text_display":"\n\nResearchers in San Diego and Dartmouth have previously studied the value of adding a","confidence":1,"confidence_rate":1},{"cnt":[[192,1923],[1823,1923],[1823,1976],[192,1976]],"region":{"top_left_x":191,"top_left_y":1923,"width":1632,"height":53},"line":27,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b9cdf7cd0ebf4c7b85a6e4c81966ba3b","type":"text","conversion_output":true,"text":"fast-acting neuromuscular blocker to an opioid before intubation in an open randomized study \\({ }^{22}\\).","text_display":" fast-acting neuromuscular blocker to an opioid before intubation in an open randomized study \\({ }^{22}\\).","confidence":1,"confidence_rate":1},{"cnt":[[192,1994],[1871,1994],[1871,2040],[192,2040]],"region":{"top_left_x":191,"top_left_y":1994,"width":1680,"height":46},"line":28,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"00795605a3b947cfabca0fd1efa31426","type":"text","conversion_output":true,"text":"The atropine-fentanyl combination was compared to the atropine-fentanyl-mivacurium combination.","text_display":" The atropine-fentanyl combination was compared to the atropine-fentanyl-mivacurium combination.","confidence":1,"confidence_rate":1},{"cnt":[[192,2061],[1825,2061],[1825,2108],[192,2108]],"region":{"top_left_x":191,"top_left_y":2060,"width":1635,"height":49},"line":29,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"57dcd64db1244c3e9dd7d75587c08fc3","type":"text","conversion_output":true,"text":"The results of this study showed that the use of neuromuscular blocker combined with analgesia","text_display":" The results of this study showed that the use of neuromuscular blocker combined with analgesia","confidence":1,"confidence_rate":1},{"cnt":[[192,2124],[1839,2124],[1839,2172],[192,2172]],"region":{"top_left_x":191,"top_left_y":2124,"width":1648,"height":49},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"344603908aec4e64a7527f547198e7bb","type":"text","conversion_output":true,"text":"and anti-cholinergic decreased the time and number of attempts needed to intubate (confirmation","text_display":" and anti-cholinergic decreased the time and number of attempts needed to intubate (confirmation","confidence":1,"confidence_rate":1},{"cnt":[[192,2188],[1796,2188],[1796,2239],[192,2239]],"region":{"top_left_x":191,"top_left_y":2188,"width":1605,"height":51},"line":31,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"4de2b4b66920465586164a1c4fb9980a","type":"text","conversion_output":true,"text":"of the secondary hypothesis) without significantly decreasing episodes of saturation lower than","text_display":" of the secondary hypothesis) without significantly decreasing episodes of saturation lower than","confidence":1,"confidence_rate":1},{"cnt":[[192,2257],[1775,2257],[1775,2305],[192,2305]],"region":{"top_left_x":191,"top_left_y":2256,"width":1584,"height":49},"line":32,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9f1e61251ae04798b4f98890b0d1fd47","type":"text","conversion_output":true,"text":"\\(75 \\%\\) (reversal of the main hypothesis). In the mivacurium group ( \\(n =21\\), mean weight: 1560 g ,","text_display":" \\(75 \\%\\) (reversal of the main hypothesis). In the mivacurium group ( \\(n =21\\), mean weight: 1560 g ,","confidence":0.9990236759185791,"confidence_rate":0.9999909555872323},{"cnt":[[192,2323],[1761,2323],[1761,2369],[192,2369]],"region":{"top_left_x":191,"top_left_y":2323,"width":1571,"height":46},"line":33,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"6b656b3f6af144afacae034321f8a3f9","type":"text","conversion_output":true,"text":"mean age adjusted 31SA), 29\\% of children experienced a desaturation episode \\(<75 \\%\\) with a","text_display":" mean age adjusted 31SA), 29\\% of children experienced a desaturation episode \\(<75 \\%\\) with a","confidence":0.9762582937255502,"confidence_rate":0.9997471048005327},{"cnt":[[192,2389],[1741,2389],[1741,2437],[192,2437]],"region":{"top_left_x":191,"top_left_y":2389,"width":1550,"height":49},"line":34,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d3535e8d7397443bbff8a694222a40ab","type":"text","conversion_output":true,"text":"duration greater than 30 s . The total duration of the procedure was \\(31 \\%\\) shorter in the group","text_display":" duration greater than 30 s . The total duration of the procedure was \\(31 \\%\\) shorter in the group","confidence":0.91259765625,"confidence_rate":0.9991375402578204},{"cnt":[[192,2453],[1734,2453],[1734,2501],[192,2501]],"region":{"top_left_x":191,"top_left_y":2453,"width":1543,"height":49},"line":35,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"79ac41983fe44d77a6bbdbb2d0799d6f","type":"text","conversion_output":true,"text":"receiving neuromuscular blocker and the total duration of laryngoscopy decreased by \\(41 \\%\\).","text_display":" receiving neuromuscular blocker and the total duration of laryngoscopy decreased by \\(41 \\%\\).","confidence":1,"confidence_rate":1},{"cnt":[[315,2522],[1761,2522],[1761,2570],[315,2570]],"region":{"top_left_x":315,"top_left_y":2521,"width":1447,"height":49},"line":36,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9cb88d2a6c064c24ab6eabbf27378ea6","type":"text","conversion_output":true,"text":"Créteil's team carried out a prospective study for the evaluation of premedication with","text_display":"\n\nCréteil's team carried out a prospective study for the evaluation of premedication with","confidence":0.9794921875,"confidence_rate":0.9997772181782927},{"cnt":[[192,2586],[1859,2586],[1859,2634],[192,2634]],"region":{"top_left_x":191,"top_left_y":2585,"width":1669,"height":49},"line":37,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a1d921e97d374bfe9874a316d0491ebd","type":"text","conversion_output":true,"text":"atropine, sufentanil and atracurium in newborns with less than 32 SA and / or less than 1500g (n =","text_display":" atropine, sufentanil and atracurium in newborns with less than 32 SA and / or less than 1500g (n =","confidence":0.6011643709362194,"confidence_rate":0.9952106858352244},{"cnt":[[1841,2755],[1878,2755],[1878,2792],[1841,2792]],"region":{"top_left_x":1841,"top_left_y":2754,"width":37,"height":38},"line":38,"column":0,"font_size":23,"is_printed":true,"is_handwritten":false,"id":"4023f3d77c9c4b0d9783e337f3ec6671","type":"page_info","conversion_output":false,"text":"6","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-07","page":7,"lines":[{"cnt":[[192,148],[1848,148],[1848,196],[192,196]],"region":{"top_left_x":191,"top_left_y":148,"width":1658,"height":49},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"6b64160a1740468faf0ff6f63ce13c16","type":"text","conversion_output":true,"text":"35 intubations, median birth weight: 850 g , mean gestational age at birth: 27.6 weeks, median age","text_display":"\n\n35 intubations, median birth weight: 850 g , mean gestational age at birth: 27.6 weeks, median age","confidence":0.99853515625,"confidence_rate":0.9999866735644114},{"cnt":[[190,206],[1775,206],[1775,263],[190,263]],"region":{"top_left_x":189,"top_left_y":205,"width":1586,"height":58},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"43b804faeed5410f87c3ad0c904efb75","type":"text","conversion_output":true,"text":"at intubation: 10 days, (IQR [4-16]) \\({ }^{50}\\).The intubation conditions reported by the operator were","text_display":" at intubation: 10 days, (IQR [4-16]) \\({ }^{50}\\).The intubation conditions reported by the operator were","confidence":0.9853830130347774,"confidence_rate":0.9998708428356244},{"cnt":[[190,279],[1789,279],[1789,331],[190,331]],"region":{"top_left_x":189,"top_left_y":278,"width":1600,"height":54},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"52089aee834940f59530e2d102a44461","type":"text","conversion_output":true,"text":"\"good or excellent\" in \\(94 \\%\\) of cases and the success rate at the first attempt of \\(75 \\%\\). However,","text_display":" \"good or excellent\" in \\(94 \\%\\) of cases and the success rate at the first attempt of \\(75 \\%\\). However,","confidence":0.8927847584709525,"confidence_rate":0.9989306687547739},{"cnt":[[192,347],[1757,347],[1757,395],[192,395]],"region":{"top_left_x":191,"top_left_y":347,"width":1566,"height":49},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9efbed65497d46818416797816d57d87","type":"text","conversion_output":true,"text":"desaturations below \\(80 \\%\\) lasting at least one minute were observed in one out of two cases.","text_display":" desaturations below \\(80 \\%\\) lasting at least one minute were observed in one out of two cases.","confidence":0.9824959910474718,"confidence_rate":0.9998198221971759},{"cnt":[[192,411],[1768,411],[1768,461],[192,461]],"region":{"top_left_x":191,"top_left_y":411,"width":1578,"height":51},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e633c1a32581489582f2cd976e26b928","type":"text","conversion_output":true,"text":"Episodes of desaturation are therefore a common adverse event in this population during the","text_display":" Episodes of desaturation are therefore a common adverse event in this population during the","confidence":1,"confidence_rate":1},{"cnt":[[192,477],[1741,477],[1741,528],[192,528]],"region":{"top_left_x":191,"top_left_y":477,"width":1550,"height":51},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"bf2795c0deba4240802c706aadad94f1","type":"text","conversion_output":true,"text":"intubation procedure with the atropine-opioid-neuromuscular blocker combination. The time","text_display":" intubation procedure with the atropine-opioid-neuromuscular blocker combination. The time","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[192,544],[1873,544],[1873,594],[192,594]],"region":{"top_left_x":191,"top_left_y":543,"width":1683,"height":51},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"5efba3ecc403483283cb0a96568412c1","type":"text","conversion_output":true,"text":"required to prepare drugs is another disadvantage of this triple therapy since Ghanta et al. reported","text_display":" required to prepare drugs is another disadvantage of this triple therapy since Ghanta et al. reported","confidence":0.93505859375,"confidence_rate":0.9993667469616127},{"cnt":[[192,603],[1812,603],[1812,660],[192,660]],"region":{"top_left_x":191,"top_left_y":603,"width":1621,"height":58},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2aea6907fa274418bccd4ea1bb84b24b","type":"text","conversion_output":true,"text":"a preparation time of 960 seconds \\((900\\) to \\(1200 s){ }^{51}\\). It is necessary to dilute the three products,","text_display":" a preparation time of 960 seconds \\((900\\) to \\(1200 s){ }^{51}\\). It is necessary to dilute the three products,","confidence":0.6259568796516124,"confidence_rate":0.996070984299905},{"cnt":[[192,676],[1784,676],[1784,724],[192,724]],"region":{"top_left_x":191,"top_left_y":676,"width":1594,"height":49},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7648948a4a274f719fd8fc4838572fd8","type":"text","conversion_output":true,"text":"each dilution exposing to a risk of error. Other notable adverse effects include the induction of","text_display":" each dilution exposing to a risk of error. Other notable adverse effects include the induction of","confidence":1,"confidence_rate":1},{"cnt":[[192,740],[1839,740],[1839,790],[192,790]],"region":{"top_left_x":191,"top_left_y":740,"width":1648,"height":51},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ec0d1686875e42308861d0006316fb4b","type":"text","conversion_output":true,"text":"thoracic rigidity or laryngospasm by fentanyl and its derivatives, making mechanical ventilation or","text_display":" thoracic rigidity or laryngospasm by fentanyl and its derivatives, making mechanical ventilation or","confidence":1,"confidence_rate":1},{"cnt":[[192,804],[1709,804],[1709,857],[192,857]],"region":{"top_left_x":191,"top_left_y":804,"width":1518,"height":53},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9ff77017d5314aac88812eeeabace453","type":"text","conversion_output":true,"text":"intubation more difficult \\({ }^{52}\\). The neuromuscular blockers, in turn, induce prolonged muscle","text_display":" intubation more difficult \\({ }^{52}\\). The neuromuscular blockers, in turn, induce prolonged muscle","confidence":1,"confidence_rate":1},{"cnt":[[192,873],[1743,873],[1743,921],[192,921]],"region":{"top_left_x":191,"top_left_y":872,"width":1552,"height":49},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"3c124e516d354c1aa7a237311f24fc0d","type":"text","conversion_output":true,"text":"relaxation and apnea requiring rapid initiation of assisted ventilation. But they do not always","text_display":" relaxation and apnea requiring rapid initiation of assisted ventilation. But they do not always","confidence":1,"confidence_rate":1},{"cnt":[[192,932],[1704,932],[1704,989],[192,989]],"region":{"top_left_x":191,"top_left_y":932,"width":1514,"height":58},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"aeec4d454c784b828f3f989c6411ee1d","type":"text","conversion_output":true,"text":"prevent the occurrence of chest blocking phenomena induced by sufentanil \\({ }^{50}\\). These two","text_display":" prevent the occurrence of chest blocking phenomena induced by sufentanil \\({ }^{50}\\). These two","confidence":0.92431640625,"confidence_rate":0.9992287207756109},{"cnt":[[192,1005],[1862,1005],[1862,1053],[192,1053]],"region":{"top_left_x":191,"top_left_y":1005,"width":1671,"height":49},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c909690bfea8461d859b4d1a062779c7","type":"text","conversion_output":true,"text":"phenomena can contribute to the occurrence of episodes of prolonged and/or severe desaturation.","text_display":" phenomena can contribute to the occurrence of episodes of prolonged and/or severe desaturation.","confidence":0.9990234375,"confidence_rate":0.999990229651252},{"cnt":[[315,1071],[1802,1071],[1802,1119],[315,1119]],"region":{"top_left_x":315,"top_left_y":1071,"width":1488,"height":49},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"25b6ed5177fd462fb1e986ae08113a5d","type":"text","conversion_output":true,"text":"In neonates, the only prospective randomized trial evaluating propofol as premedication","text_display":"\n\nIn neonates, the only prospective randomized trial evaluating propofol as premedication","confidence":1,"confidence_rate":1},{"cnt":[[192,1133],[1812,1133],[1812,1186],[192,1186]],"region":{"top_left_x":191,"top_left_y":1133,"width":1621,"height":53},"line":16,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"6e7521e0b0e942a0bc85eba139f9ab6c","type":"text","conversion_output":true,"text":"before intubation was performed in an Australian center \\({ }^{51}\\). The hypothesis was that by allowing","text_display":" before intubation was performed in an Australian center \\({ }^{51}\\). The hypothesis was that by allowing","confidence":1,"confidence_rate":1},{"cnt":[[192,1202],[1734,1202],[1734,1250],[192,1250]],"region":{"top_left_x":191,"top_left_y":1201,"width":1543,"height":49},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a3b01407c9fb42698ae38290bf72fe01","type":"text","conversion_output":true,"text":"spontaneous breathing, the propofol-treated group would have fewer apneas and therefore","text_display":" spontaneous breathing, the propofol-treated group would have fewer apneas and therefore","confidence":1,"confidence_rate":1},{"cnt":[[192,1270],[1871,1270],[1871,1318],[192,1318]],"region":{"top_left_x":191,"top_left_y":1270,"width":1680,"height":49},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b928730d1cdc4438a8a190c8df78317a","type":"text","conversion_output":true,"text":"potentially fewer episodes of hypoxemia during the procedure. The authors compared propofol at a","text_display":" potentially fewer episodes of hypoxemia during the procedure. The authors compared propofol at a","confidence":1,"confidence_rate":1},{"cnt":[[192,1334],[1720,1334],[1720,1382],[192,1382]],"region":{"top_left_x":191,"top_left_y":1334,"width":1530,"height":49},"line":19,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"164a47d380f640dead6819e477c1e310","type":"text","conversion_output":true,"text":"dose of \\(2.5 mg / kg\\) renewable as needed ( \\(n =33\\) ) to a morphine-atropine-suxamethonium","text_display":" dose of \\(2.5 mg / kg\\) renewable as needed ( \\(n =33\\) ) to a morphine-atropine-suxamethonium","confidence":0.9868226051330566,"confidence_rate":0.999869959563078},{"cnt":[[192,1403],[1816,1403],[1816,1451],[192,1451]],"region":{"top_left_x":191,"top_left_y":1402,"width":1626,"height":49},"line":20,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"456ed229e8ee4bd38314bf45c4f0e4b8","type":"text","conversion_output":true,"text":"combination ( \\(n =30\\) ) in neonates born at 25 to 31 weeks of gestation, with birth weights ranging","text_display":" combination ( \\(n =30\\) ) in neonates born at 25 to 31 weeks of gestation, with birth weights ranging","confidence":0.9931640625,"confidence_rate":0.9999392991029855},{"cnt":[[192,1467],[1832,1467],[1832,1515],[192,1515]],"region":{"top_left_x":191,"top_left_y":1466,"width":1642,"height":49},"line":21,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a6b6f76c4bfe41a49d5a458dbc749b85","type":"text","conversion_output":true,"text":"from 759 to 1612 g , intubation weight from 810 to 1972 g , and age at intubation from 1 to 33 days.","text_display":" from 759 to 1612 g , intubation weight from 810 to 1972 g , and age at intubation from 1 to 33 days.","confidence":1,"confidence_rate":1},{"cnt":[[192,1531],[1843,1531],[1843,1579],[192,1579]],"region":{"top_left_x":191,"top_left_y":1530,"width":1653,"height":49},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2597132432714882ab19402a65127faf","type":"text","conversion_output":true,"text":"The results showed that sufficient muscle relaxation or sleep was achieved in 60 seconds in each","text_display":" The results showed that sufficient muscle relaxation or sleep was achieved in 60 seconds in each","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[192,1599],[1802,1599],[1802,1647],[192,1647]],"region":{"top_left_x":191,"top_left_y":1599,"width":1612,"height":49},"line":23,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"41c4b0492c044ff1a1bfd47da021e090","type":"text","conversion_output":true,"text":"group and that the intubation time was significantly shorter in the \"propofol\" group (120s versus","text_display":" group and that the intubation time was significantly shorter in the \"propofol\" group (120s versus","confidence":0.9599609375,"confidence_rate":0.9995994656720416},{"cnt":[[192,1665],[1775,1665],[1775,1711],[192,1711]],"region":{"top_left_x":191,"top_left_y":1665,"width":1584,"height":46},"line":24,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"066542f98cb04ff8a0bb86661fe5f207","type":"text","conversion_output":true,"text":"260s). No difference in blood pressure and heart rate was observed between the groups. The","text_display":" 260s). No difference in blood pressure and heart rate was observed between the groups. The","confidence":1,"confidence_rate":1},{"cnt":[[192,1732],[1793,1732],[1793,1780],[192,1780]],"region":{"top_left_x":191,"top_left_y":1731,"width":1603,"height":49},"line":25,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"de90284fa2ff420a87e76ef4c87cbf0a","type":"text","conversion_output":true,"text":"median minimum oxygen saturation values during the procedure were significantly lower in the","text_display":" median minimum oxygen saturation values during the procedure were significantly lower in the","confidence":1,"confidence_rate":1},{"cnt":[[192,1796],[1745,1796],[1745,1843],[192,1843]],"region":{"top_left_x":191,"top_left_y":1795,"width":1555,"height":49},"line":26,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2c1bea82143949beb1730438b519071b","type":"text","conversion_output":true,"text":"\"morphine-atropine-suxamethonium\" group ( 60 versus \\(80 \\%\\) ). However, this minimum single","text_display":" \"morphine-atropine-suxamethonium\" group ( 60 versus \\(80 \\%\\) ). However, this minimum single","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[192,1859],[1793,1859],[1793,1910],[192,1910]],"region":{"top_left_x":191,"top_left_y":1859,"width":1603,"height":51},"line":27,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f09738f51490406eb3a21f26f1d5d248","type":"text","conversion_output":true,"text":"saturation value does not necessarily indicate the duration or severity of hypoxia. The onset of","text_display":" saturation value does not necessarily indicate the duration or severity of hypoxia. The onset of","confidence":1,"confidence_rate":1},{"cnt":[[192,1928],[1848,1928],[1848,1976],[192,1976]],"region":{"top_left_x":191,"top_left_y":1928,"width":1658,"height":48},"line":28,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"174214e16ad34b4cb8ee4694dbdee1b7","type":"text","conversion_output":true,"text":"anesthesia was faster in the \"propofol\" group ( 780 vs 1425s) and no serious adverse events were","text_display":" anesthesia was faster in the \"propofol\" group ( 780 vs 1425s) and no serious adverse events were","confidence":0.7705027610063553,"confidence_rate":0.9974962929693592},{"cnt":[[192,1994],[1594,1994],[1594,2045],[192,2045]],"region":{"top_left_x":191,"top_left_y":1994,"width":1404,"height":51},"line":29,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"cf5e77d8ad7f448da152edd514aad327","type":"text","conversion_output":true,"text":"observed during the study, including no grade III or IV intraventricular hemorrhage.","text_display":" observed during the study, including no grade III or IV intraventricular hemorrhage.","confidence":1,"confidence_rate":1},{"cnt":[[315,2061],[1789,2061],[1789,2108],[315,2108]],"region":{"top_left_x":315,"top_left_y":2060,"width":1474,"height":49},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"fd30b9dc3656466887455c49a394c0e0","type":"text","conversion_output":true,"text":"Other descriptive studies have been published on the use of propofol as premedication","text_display":"\n\nOther descriptive studies have been published on the use of propofol as premedication","confidence":1,"confidence_rate":1},{"cnt":[[192,2124],[1830,2124],[1830,2177],[192,2177]],"region":{"top_left_x":191,"top_left_y":2124,"width":1639,"height":54},"line":31,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1068b3b5ca59476bb0771e6b42ebb7c8","type":"text","conversion_output":true,"text":"before neonatal intubation. Papoff et al. reported the use of fentanyl ( \\(1.5 \\mu g / kg\\) in 1 minute) and","text_display":" before neonatal intubation. Papoff et al. reported the use of fentanyl ( \\(1.5 \\mu g / kg\\) in 1 minute) and","confidence":0.9902691231691538,"confidence_rate":0.9999149729088278},{"cnt":[[192,2184],[1830,2184],[1830,2241],[192,2241]],"region":{"top_left_x":191,"top_left_y":2183,"width":1639,"height":58},"line":32,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"5a5659329e4f4945ad00e60cf38d5cd9","type":"text","conversion_output":true,"text":"propofol ( \\(2 mg / kg\\) in 20 seconds) in 21 term or near term neonates \\({ }^{53}\\). The intubation conditions","text_display":" propofol ( \\(2 mg / kg\\) in 20 seconds) in 21 term or near term neonates \\({ }^{53}\\). The intubation conditions","confidence":0.9786097593605518,"confidence_rate":0.9998284089504218},{"cnt":[[192,2257],[1812,2257],[1812,2305],[192,2305]],"region":{"top_left_x":191,"top_left_y":2256,"width":1621,"height":49},"line":33,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ba2118eb1ae441059e2769cfae1c3058","type":"text","conversion_output":true,"text":"were good despite the occurrence of abrupt desaturations ( \\(>60 \\%\\) ) in 7 cases. In the majority of","text_display":" were good despite the occurrence of abrupt desaturations ( \\(>60 \\%\\) ) in 7 cases. In the majority of","confidence":0.9246328092616046,"confidence_rate":0.9992679448753373},{"cnt":[[192,2323],[1843,2323],[1843,2371],[192,2371]],"region":{"top_left_x":191,"top_left_y":2323,"width":1653,"height":49},"line":34,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"41110d96f7e04021a6c5d6d4a3bc992c","type":"text","conversion_output":true,"text":"these cases, these desaturations were accompanied by a drop in blood pressure (undefined) that","text_display":" these cases, these desaturations were accompanied by a drop in blood pressure (undefined) that","confidence":0.9951171875,"confidence_rate":0.9999505590770232},{"cnt":[[192,2389],[1830,2389],[1830,2437],[192,2437]],"region":{"top_left_x":191,"top_left_y":2389,"width":1639,"height":49},"line":35,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8cee508d77524ba8809bca6bfa8e962b","type":"text","conversion_output":true,"text":"the authors treated with the administration of \\(10 ml / kg\\) of normal saline bolus. In conclusion, the","text_display":" the authors treated with the administration of \\(10 ml / kg\\) of normal saline bolus. In conclusion, the","confidence":0.99560546875,"confidence_rate":0.9999603231692639},{"cnt":[[192,2453],[1167,2453],[1167,2497],[192,2497]],"region":{"top_left_x":191,"top_left_y":2453,"width":977,"height":44},"line":36,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e67c9e8e60eb4138aeb08e6f0e77ecf9","type":"text","conversion_output":true,"text":"authors considered this association as safe and effective.","text_display":" authors considered this association as safe and effective.","confidence":1,"confidence_rate":1},{"cnt":[[315,2522],[1871,2522],[1871,2570],[315,2570]],"region":{"top_left_x":315,"top_left_y":2521,"width":1556,"height":49},"line":37,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"eb04d5c3326c4802891648c7f6762e3f","type":"text","conversion_output":true,"text":"More recently, Welzing et al. published a pilot study of 13 newborns less than 8 hours of life","text_display":"\n\nMore recently, Welzing et al. published a pilot study of 13 newborns less than 8 hours of life","confidence":0.9980478286743164,"confidence_rate":0.999981389894164},{"cnt":[[192,2581],[1761,2581],[1761,2634],[192,2634]],"region":{"top_left_x":191,"top_left_y":2581,"width":1571,"height":53},"line":38,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e064d3840bd44b668414cd171e76eb49","type":"text","conversion_output":true,"text":"eligible for the INSURE procedure (INtubation SUrfactant Extubation) \\({ }^{54}\\). This pilot study was","text_display":" eligible for the INSURE procedure (INtubation SUrfactant Extubation) \\({ }^{54}\\). This pilot study was","confidence":1,"confidence_rate":1},{"cnt":[[1841,2755],[1878,2755],[1878,2794],[1841,2794]],"region":{"top_left_x":1841,"top_left_y":2754,"width":37,"height":40},"line":39,"column":0,"font_size":23,"is_printed":true,"is_handwritten":false,"id":"49f7a2d777bf47c584dc52eb3b266a41","type":"page_info","conversion_output":false,"text":"7","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-08","page":8,"lines":[{"cnt":[[192,148],[1793,148],[1793,196],[192,196]],"region":{"top_left_x":191,"top_left_y":148,"width":1603,"height":49},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f78f158bbdd548b8b19f531f20324f87","type":"text","conversion_output":true,"text":"prematurely interrupted due to the frequency of arterial hypotension defined by a mean arterial","text_display":"\nprematurely interrupted due to the frequency of arterial hypotension defined by a mean arterial","confidence":1,"confidence_rate":1},{"cnt":[[192,215],[1830,215],[1830,263],[192,263]],"region":{"top_left_x":191,"top_left_y":214,"width":1639,"height":49},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e6e6b303e7f54e2db5e2656f773360f5","type":"text","conversion_output":true,"text":"blood pressure \\(<25 mm Hg\\). Propofol was administered as a bolus dose of \\(1 mg / kg\\) in the first 6","text_display":" blood pressure \\(<25 mm Hg\\). Propofol was administered as a bolus dose of \\(1 mg / kg\\) in the first 6","confidence":0.6642196211032569,"confidence_rate":0.996320817007132},{"cnt":[[192,279],[1750,279],[1750,331],[192,331]],"region":{"top_left_x":191,"top_left_y":278,"width":1559,"height":54},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"51104577083742069c926ca0fee11be2","type":"text","conversion_output":true,"text":"patients and over 60 seconds in the 7 following. In the first phase (bolus), 3 out of 6 patients","text_display":" patients and over 60 seconds in the 7 following. In the first phase (bolus), 3 out of 6 patients","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[192,343],[1780,343],[1780,395],[192,395]],"region":{"top_left_x":191,"top_left_y":342,"width":1589,"height":54},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e590220cd69f4f8d98efb1614092b4e8","type":"text","conversion_output":true,"text":"experienced hypotension \\(<25 mmHg 10\\) minutes after administration. In the second phase (1-","text_display":" experienced hypotension \\(<25 mmHg 10\\) minutes after administration. In the second phase (1","confidence":0.99365234375,"confidence_rate":0.9999350236591895},{"cnt":[[192,411],[1775,411],[1775,461],[192,461]],"region":{"top_left_x":191,"top_left_y":411,"width":1584,"height":51},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7d5ee283ce984a3fbff30743e2b988c0","type":"text","conversion_output":true,"text":"minute injection), two patients experienced hypotension \\(<25 mm Hg\\). In these 7 infants, mean","text_display":"minute injection), two patients experienced hypotension \\(<25 mm Hg\\). In these 7 infants, mean","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[192,477],[1750,477],[1750,528],[192,528]],"region":{"top_left_x":191,"top_left_y":477,"width":1559,"height":51},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"983153b23412473baaeb45fdf005f5a6","type":"text","conversion_output":true,"text":"pressure decreased from 37 mmHg to 28 mmHg 5 minutes after propofol administration. No","text_display":" pressure decreased from 37 mmHg to 28 mmHg 5 minutes after propofol administration. No","confidence":1,"confidence_rate":1},{"cnt":[[192,544],[1770,544],[1770,592],[192,592]],"region":{"top_left_x":191,"top_left_y":543,"width":1580,"height":49},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1e3f5acf9f454e3eb1c63c18364c2c96","type":"text","conversion_output":true,"text":"significant changes in heart rate and O 2 saturation were observed. No complications such as","text_display":" significant changes in heart rate and O 2 saturation were observed. No complications such as","confidence":1,"confidence_rate":1},{"cnt":[[192,612],[1839,612],[1839,660],[192,660]],"region":{"top_left_x":191,"top_left_y":612,"width":1648,"height":49},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b696eacf982f4ac8af6d6c9af114bb7a","type":"text","conversion_output":true,"text":"intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, retinopathy or","text_display":" intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, retinopathy or","confidence":1,"confidence_rate":1},{"cnt":[[192,676],[1841,676],[1841,724],[192,724]],"region":{"top_left_x":191,"top_left_y":676,"width":1651,"height":49},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ba3b722fe8ad439c88bd9132b69d7d53","type":"text","conversion_output":true,"text":"bronchopulmonary dysplasia were observed in the 13 children who participated in the study. 85\\%","text_display":" bronchopulmonary dysplasia were observed in the 13 children who participated in the study. 85\\%","confidence":0.89013671875,"confidence_rate":0.9988596682075035},{"cnt":[[192,740],[1510,740],[1510,788],[192,788]],"region":{"top_left_x":191,"top_left_y":740,"width":1319,"height":49},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ccb5de5c1edb4b58bc7d943d03920760","type":"text","conversion_output":true,"text":"of intubations were performed under conditions deemed \"good\" or \"excellent\".","text_display":" of intubations were performed under conditions deemed \"good\" or \"excellent\".","confidence":0.9912109375,"confidence_rate":0.999891019344705},{"cnt":[[315,800],[1871,800],[1871,857],[315,857]],"region":{"top_left_x":315,"top_left_y":799,"width":1556,"height":58},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c2b689bb85eb4f5d83752b7201bcbf13","type":"text","conversion_output":true,"text":"In 2013, Simons et al. published their experience with propofol in 62 neonatal intubations \\({ }^{55}\\).","text_display":"\n\nIn 2013, Simons et al. published their experience with propofol in 62 neonatal intubations \\({ }^{55}\\).","confidence":0.9477791786193848,"confidence_rate":0.9995254777734579},{"cnt":[[190,873],[1830,873],[1830,921],[190,921]],"region":{"top_left_x":189,"top_left_y":872,"width":1641,"height":49},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"37df3fc18ef3447bbb6a7bfee619e6de","type":"text","conversion_output":true,"text":"The initial dose of \\(2 mg / kg\\) was sufficient for \\(37 \\%\\) of patients. Hypotension occurred in \\(39 \\%\\) and","text_display":" The initial dose of \\(2 mg / kg\\) was sufficient for \\(37 \\%\\) of patients. Hypotension occurred in \\(39 \\%\\) and","confidence":0.9956102357245982,"confidence_rate":0.9999614092746348},{"cnt":[[192,941],[1713,941],[1713,989],[192,989]],"region":{"top_left_x":191,"top_left_y":941,"width":1523,"height":49},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"078144f0845a410aac9be2a9ede8405b","type":"text","conversion_output":true,"text":"was more common in the first day of life. However, the diversity of associated pathologies","text_display":" was more common in the first day of life. However, the diversity of associated pathologies","confidence":1,"confidence_rate":1},{"cnt":[[192,1005],[1711,1005],[1711,1053],[192,1053]],"region":{"top_left_x":191,"top_left_y":1005,"width":1520,"height":49},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"aa5b1f8901664ac591ed5856a484a34a","type":"text","conversion_output":true,"text":"(necrotizing enterocolitis, sepsis) could potentially have increased the risk of hypotension.","text_display":" (necrotizing enterocolitis, sepsis) could potentially have increased the risk of hypotension.","confidence":1,"confidence_rate":1},{"cnt":[[315,1069],[1647,1069],[1647,1119],[315,1119]],"region":{"top_left_x":315,"top_left_y":1069,"width":1333,"height":51},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e6aa6c3969a3408b82dce48be14def84","type":"text","conversion_output":true,"text":"Between March 2007 and December 2008, the NICU at the Centre Hospitalier","text_display":"\n\nBetween March 2007 and December 2008, the NICU at the Centre Hospitalier","confidence":1,"confidence_rate":1},{"cnt":[[192,1138],[1766,1138],[1766,1186],[192,1186]],"region":{"top_left_x":191,"top_left_y":1137,"width":1575,"height":49},"line":16,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"dd63903b32694852b13adfef557bff3a","type":"text","conversion_output":true,"text":"Intercommunal de Creteil conducted an observational study of 33 intubations with propofol in","text_display":" Intercommunal de Creteil conducted an observational study of 33 intubations with propofol in","confidence":1,"confidence_rate":1},{"cnt":[[192,1197],[1752,1197],[1752,1250],[192,1250]],"region":{"top_left_x":191,"top_left_y":1197,"width":1562,"height":53},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"37ba5c3e063441e5b12021648713e5d6","type":"text","conversion_output":true,"text":"infantsborn after 32 weeks of gestation \\({ }^{56}\\). The dose of \\(2.5 mg / kg\\) was administered over 60","text_display":" infantsborn after 32 weeks of gestation \\({ }^{56}\\). The dose of \\(2.5 mg / kg\\) was administered over 60","confidence":1,"confidence_rate":1},{"cnt":[[192,1270],[1732,1270],[1732,1318],[192,1318]],"region":{"top_left_x":191,"top_left_y":1270,"width":1541,"height":49},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9961974c7e4a48d3a0579ddfcd191eba","type":"text","conversion_output":true,"text":"seconds and could be repeated if necessary. Intubation conditions were rated as \"good\" or","text_display":" seconds and could be repeated if necessary. Intubation conditions were rated as \"good\" or","confidence":0.9985356330871582,"confidence_rate":0.9999844103327336},{"cnt":[[192,1334],[1830,1334],[1830,1384],[192,1384]],"region":{"top_left_x":191,"top_left_y":1334,"width":1639,"height":51},"line":19,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"340fe1efbfe54dbaaf722b4a509bfab5","type":"text","conversion_output":true,"text":"\"excellent\" in \\(91 \\%\\) of cases. Desaturation <80\\% for at least 1 minute occurred in 17 cases ( \\(52 \\%\\) )","text_display":" \"excellent\" in \\(91 \\%\\) of cases. Desaturation <80\\% for at least 1 minute occurred in 17 cases ( \\(52 \\%\\) )","confidence":0.3921489945285548,"confidence_rate":0.9918221011900311},{"cnt":[[192,1403],[1812,1403],[1812,1451],[192,1451]],"region":{"top_left_x":191,"top_left_y":1402,"width":1621,"height":49},"line":20,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"014a47387438494f8137868a9636a160","type":"text","conversion_output":true,"text":"and bradycardia <100/min for at least 1 minute in 5 cases ( \\(15 \\%\\) ). Mean arterial blood pressure","text_display":" and bradycardia <100/min for at least 1 minute in 5 cases ( \\(15 \\%\\) ). Mean arterial blood pressure","confidence":0.6877738232069041,"confidence_rate":0.996571987807837},{"cnt":[[192,1467],[1812,1467],[1812,1515],[192,1515]],"region":{"top_left_x":191,"top_left_y":1466,"width":1621,"height":49},"line":21,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"aa59d175a1004654858e086acfda0c3c","type":"text","conversion_output":true,"text":"decreased at 5 and 10 minutes after injection (respectively -6.6 and -9.9 mmHg ) but normalized","text_display":" decreased at 5 and 10 minutes after injection (respectively -6.6 and -9.9 mmHg ) but normalized","confidence":1,"confidence_rate":1},{"cnt":[[192,1531],[1850,1531],[1850,1579],[192,1579]],"region":{"top_left_x":191,"top_left_y":1530,"width":1660,"height":49},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"95f3dccaa1a44b5aa0dcc1faf9ce009f","type":"text","conversion_output":true,"text":"spontaneously 15 minutes after injection. No significant changes in heart rate were observed. The","text_display":" spontaneously 15 minutes after injection. No significant changes in heart rate were observed. The","confidence":1,"confidence_rate":1},{"cnt":[[192,1599],[1843,1599],[1843,1647],[192,1647]],"region":{"top_left_x":191,"top_left_y":1599,"width":1653,"height":49},"line":23,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e84ac5d126f74664aae034da5f0a8509","type":"text","conversion_output":true,"text":"identified risk factors for onset of desaturation were lower pre-intubation SpO 2 ( \\(93 \\%\\) vs \\(98 \\%\\) ) and","text_display":" identified risk factors for onset of desaturation were lower pre-intubation SpO 2 ( \\(93 \\%\\) vs \\(98 \\%\\) ) and","confidence":0.5665108328616597,"confidence_rate":0.9951131943381566},{"cnt":[[192,1663],[1049,1663],[1049,1713],[192,1713]],"region":{"top_left_x":191,"top_left_y":1663,"width":858,"height":51},"line":24,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"859146ba606544e49a0754f5198efebc","type":"text","conversion_output":true,"text":"longer duration of intubation ( 394 sec vs 167 sec ).","text_display":" longer duration of intubation ( 394 sec vs 167 sec ).","confidence":0.7983552439721209,"confidence_rate":0.9966936895002314},{"cnt":[[187,1828],[1656,1828],[1656,1891],[187,1891]],"region":{"top_left_x":187,"top_left_y":1827,"width":1470,"height":65},"line":25,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"d3ac806cdd7a4eaca6202e152d6eb416","type":"section_header","conversion_output":false,"children_ids":["a2a9326a52834444936e1cfc12cb2cdf"],"text":"","text_display":""},{"cnt":[[192,1834],[1649,1834],[1649,1885],[192,1885]],"region":{"top_left_x":191,"top_left_y":1834,"width":1459,"height":51},"line":26,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"a2a9326a52834444936e1cfc12cb2cdf","type":"text","conversion_output":true,"parent_id":"d3ac806cdd7a4eaca6202e152d6eb416","text":"Predictable benefits and risks known to patients who are eligible for research","text_display":"\n\n\\section*{Predictable benefits and risks known to patients who are eligible for research}","confidence":1,"confidence_rate":1},{"cnt":[[192,1933],[1782,1933],[1782,1983],[192,1983]],"region":{"top_left_x":191,"top_left_y":1932,"width":1591,"height":51},"line":27,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"6f2e7d697dd541c1b203823436bc2b4c","type":"text","conversion_output":true,"text":"The expected benefit for infants participating in this study is the systematic administration of a","text_display":"\n\nThe expected benefit for infants participating in this study is the systematic administration of a","confidence":0.9975595474243164,"confidence_rate":0.9999762776082356},{"cnt":[[192,2001],[1798,2001],[1798,2049],[192,2049]],"region":{"top_left_x":191,"top_left_y":2001,"width":1607,"height":49},"line":28,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"abbf8ae33d704100b0f9afb8eb8b10e1","type":"text","conversion_output":true,"text":"premedication before tracheal intubation except forlife-threatening situations. These infants will","text_display":" premedication before tracheal intubation except forlife-threatening situations. These infants will","confidence":1,"confidence_rate":1},{"cnt":[[192,2065],[1403,2065],[1403,2113],[192,2113]],"region":{"top_left_x":191,"top_left_y":2065,"width":1212,"height":49},"line":29,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7018077d96174039a726dab0e13bd179","type":"text","conversion_output":true,"text":"also benefit from sustained surveillance during and after the procedure.","text_display":" also benefit from sustained surveillance during and after the procedure.","confidence":1,"confidence_rate":1},{"cnt":[[192,2134],[1761,2134],[1761,2179],[192,2179]],"region":{"top_left_x":191,"top_left_y":2133,"width":1571,"height":47},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"00f1292b33ae46de993b453df2810b6d","type":"text","conversion_output":true,"text":"The expected risks are those commonly described during tracheal intubation in the newborn:","text_display":"\n\nThe expected risks are those commonly described during tracheal intubation in the newborn:","confidence":1,"confidence_rate":1},{"cnt":[[192,2198],[1775,2198],[1775,2246],[192,2246]],"region":{"top_left_x":191,"top_left_y":2197,"width":1584,"height":49},"line":31,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"58286bdc622a471196577dde9b220d3e","type":"text","conversion_output":true,"text":"bradycardia, desaturation, trauma to the upper airways. Premedication should avoid pain and","text_display":" bradycardia, desaturation, trauma to the upper airways. Premedication should avoid pain and","confidence":1,"confidence_rate":1},{"cnt":[[192,2266],[1802,2266],[1802,2310],[192,2310]],"region":{"top_left_x":191,"top_left_y":2266,"width":1612,"height":44},"line":32,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"aeaac8aa04bf4de2ba871772fabc74bd","type":"text","conversion_output":true,"text":"discomfort, but expose children to the theoretical risk of chest stiffness and low blood pressure.","text_display":" discomfort, but expose children to the theoretical risk of chest stiffness and low blood pressure.","confidence":1,"confidence_rate":1},{"cnt":[[192,2323],[1825,2323],[1825,2378],[192,2378]],"region":{"top_left_x":191,"top_left_y":2323,"width":1635,"height":56},"line":33,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7b49922ae24a46d38524a599e44d762a","type":"text","conversion_output":true,"text":"The interpretation of arterial hypotension in preterm infants is extremely difficult \\({ }^{57}\\). Indeed, it has","text_display":" The interpretation of arterial hypotension in preterm infants is extremely difficult \\({ }^{57}\\). Indeed, it has","confidence":1,"confidence_rate":1},{"cnt":[[192,2396],[1748,2396],[1748,2442],[192,2442]],"region":{"top_left_x":191,"top_left_y":2396,"width":1557,"height":46},"line":34,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"fc04410109d648ecb990c6b9f84f3ff9","type":"text","conversion_output":true,"text":"been shown that the correlation between blood pressure and cardiac output is poor in these","text_display":" been shown that the correlation between blood pressure and cardiac output is poor in these","confidence":1,"confidence_rate":1},{"cnt":[[192,2456],[1848,2456],[1848,2511],[192,2511]],"region":{"top_left_x":191,"top_left_y":2455,"width":1658,"height":56},"line":35,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"af4516ac9d0246b899a379edec820f1e","type":"text","conversion_output":true,"text":"children \\({ }^{58}\\). Upper vena cava flow was more predictive of neurodevelopmental outcome at 3 years","text_display":" children \\({ }^{58}\\). Upper vena cava flow was more predictive of neurodevelopmental outcome at 3 years","confidence":1,"confidence_rate":1},{"cnt":[[192,2522],[1738,2522],[1738,2579],[192,2579]],"region":{"top_left_x":191,"top_left_y":2521,"width":1548,"height":59},"line":36,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d26ec4b979db4193957f3cd4537a9fe8","type":"text","conversion_output":true,"text":"than arterial hypotension in premature infants \\({ }^{59}\\). However, routine measurement is difficult,","text_display":" than arterial hypotension in premature infants \\({ }^{59}\\). However, routine measurement is difficult,","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[192,2595],[672,2595],[672,2643],[192,2643]],"region":{"top_left_x":191,"top_left_y":2595,"width":481,"height":49},"line":37,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"6eb4310f97e348efacab936f6519b3be","type":"text","conversion_output":true,"text":"especially during intubation.","text_display":" especially during intubation.","confidence":1,"confidence_rate":1},{"cnt":[[1841,2755],[1878,2755],[1878,2792],[1841,2792]],"region":{"top_left_x":1841,"top_left_y":2754,"width":37,"height":38},"line":38,"column":0,"font_size":23,"is_printed":true,"is_handwritten":false,"id":"9d4b41dd77cd46dfbaf69baf467523ea","type":"page_info","conversion_output":false,"text":"R","text_display":"","confidence":0.1961669921875,"confidence_rate":0.7622620915585067}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-09","page":9,"lines":[{"cnt":[[315,148],[1711,148],[1711,194],[315,194]],"region":{"top_left_x":315,"top_left_y":148,"width":1396,"height":47},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2fb2f62535d14cff863fa1de0b2382ae","type":"text","conversion_output":true,"text":"Concerning neurodevelopmental outcome, no evidence in human clinical research","text_display":"\n\nConcerning neurodevelopmental outcome, no evidence in human clinical research","confidence":1,"confidence_rate":1},{"cnt":[[192,215],[1720,215],[1720,263],[192,263]],"region":{"top_left_x":191,"top_left_y":214,"width":1530,"height":49},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"582398ac657f4bd19ce222a2981216a8","type":"text","conversion_output":true,"text":"(exclusively retrospective data) allows to fear a possible toxicity of non-surgical anesthetic","text_display":" (exclusively retrospective data) allows to fear a possible toxicity of non-surgical anesthetic","confidence":1,"confidence_rate":1},{"cnt":[[190,274],[1761,274],[1761,331],[190,331]],"region":{"top_left_x":189,"top_left_y":274,"width":1573,"height":58},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"058dc09dea914654a17b5f0af67190ab","type":"text","conversion_output":true,"text":"treatment in neonates hospitalized in \\(NICU ^{48,60,61}\\). However, short and long term neurological","text_display":" treatment in neonates hospitalized in \\(NICU ^{48,60,61}\\). However, short and long term neurological","confidence":0.9892714023590088,"confidence_rate":0.9999036960302387},{"cnt":[[192,343],[692,343],[692,395],[192,395]],"region":{"top_left_x":191,"top_left_y":342,"width":502,"height":54},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f54233b66eed42df818d44ef8b2dbee2","type":"text","conversion_output":true,"text":"monitoring will be performed.","text_display":" monitoring will be performed.","confidence":1,"confidence_rate":1},{"cnt":[[183,507],[1761,507],[1761,628],[183,628]],"region":{"top_left_x":182,"top_left_y":507,"width":1580,"height":122},"line":5,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"2022124599be4e6c852bc3c0b127823f","type":"section_header","conversion_output":false,"children_ids":["dfe01f5b196b4036a06ab7e7f01dc470","dc9acfc46c6c40198b52e740c0481fcb"],"text":"","text_display":""},{"cnt":[[192,516],[1752,516],[1752,569],[192,569]],"region":{"top_left_x":191,"top_left_y":516,"width":1562,"height":53},"line":6,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"dfe01f5b196b4036a06ab7e7f01dc470","type":"text","conversion_output":true,"parent_id":"2022124599be4e6c852bc3c0b127823f","text":"Description and justification of the route of administration, dosage, administration","text_display":"\n\n\\section*{Description and justification of the route of administration, dosage, administration","confidence":0.9985356330871582,"confidence_rate":0.9999835345159404},{"cnt":[[192,571],[873,571],[873,624],[192,624]],"region":{"top_left_x":191,"top_left_y":571,"width":682,"height":53},"line":7,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"dc9acfc46c6c40198b52e740c0481fcb","type":"text","conversion_output":true,"parent_id":"2022124599be4e6c852bc3c0b127823f","text":"schedule and duration of treatment","text_display":" schedule and duration of treatment}","confidence":1,"confidence_rate":1},{"cnt":[[192,690],[1711,690],[1711,738],[192,738]],"region":{"top_left_x":191,"top_left_y":689,"width":1520,"height":49},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"596acaf7a1074d5997c09d40e167b156","type":"text","conversion_output":true,"text":"The drugs studied are strictly reserved for the intravenous route. These treatments will be","text_display":"\n\nThe drugs studied are strictly reserved for the intravenous route. These treatments will be","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[192,754],[1720,754],[1720,806],[192,806]],"region":{"top_left_x":191,"top_left_y":753,"width":1530,"height":54},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"bdc8762bbb244ad28653472f2a5ede36","type":"text","conversion_output":true,"text":"evaluated for a single episode of intubation corresponding to a single administration of the","text_display":" evaluated for a single episode of intubation corresponding to a single administration of the","confidence":1,"confidence_rate":1},{"cnt":[[192,822],[391,822],[391,866],[192,866]],"region":{"top_left_x":191,"top_left_y":822,"width":200,"height":44},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"4d12e5231ce54fd6bd1cbc6580bda49a","type":"text","conversion_output":true,"text":"treatments.","text_display":" treatments.","confidence":1,"confidence_rate":1},{"cnt":[[185,879],[605,879],[605,943],[185,943]],"region":{"top_left_x":185,"top_left_y":879,"width":421,"height":65},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0590ee1787ee40828c62f7e860a13461","type":"section_header","conversion_output":false,"children_ids":["b590a1fb66df436bbb661479cb3ef465"],"text":"","text_display":""},{"cnt":[[192,886],[596,886],[596,934],[192,934]],"region":{"top_left_x":191,"top_left_y":886,"width":406,"height":49},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b590a1fb66df436bbb661479cb3ef465","type":"text","conversion_output":true,"parent_id":"0590ee1787ee40828c62f7e860a13461","text":"Determination of doses","text_display":"\n\n\\section*{Determination of doses}","confidence":1,"confidence_rate":1},{"cnt":[[190,950],[1862,950],[1862,1003],[190,1003]],"region":{"top_left_x":189,"top_left_y":950,"width":1673,"height":53},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f7020dc9924c43a4aa4fa81ccefaac49","type":"text","conversion_output":true,"text":"All children will receive atropine at a dose of \\(0.02 mg / kg\\) IVD, ie \\(0.08 ml / kg\\) of the 1 ml solution =","text_display":"\n\nAll children will receive atropine at a dose of \\(0.02 mg / kg\\) IVD, ie \\(0.08 ml / kg\\) of the 1 ml solution =","confidence":0.8474735935385524,"confidence_rate":0.9986874050780802},{"cnt":[[190,1019],[1821,1019],[1821,1067],[190,1067]],"region":{"top_left_x":189,"top_left_y":1018,"width":1632,"height":49},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d1ad8bf04b574f52bc60f6e9c46e93bf","type":"text","conversion_output":true,"text":"0.25 mg . This dose is routinely used in pre-anesthesia to prevent vagal bradycardias associated","text_display":" 0.25 mg . This dose is routinely used in pre-anesthesia to prevent vagal bradycardias associated","confidence":1,"confidence_rate":1},{"cnt":[[190,1078],[1839,1078],[1839,1135],[190,1135]],"region":{"top_left_x":189,"top_left_y":1078,"width":1650,"height":58},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c71aba59d5d94ffabf5a3cd64d15bb14","type":"text","conversion_output":true,"text":"with the use of neuromuscular blockers \\({ }^{62}\\). Atropine will be routinely administered to prevent vagal","text_display":" with the use of neuromuscular blockers \\({ }^{62}\\). Atropine will be routinely administered to prevent vagal","confidence":1,"confidence_rate":1},{"cnt":[[192,1142],[939,1142],[939,1199],[192,1199]],"region":{"top_left_x":191,"top_left_y":1142,"width":748,"height":58},"line":16,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"fa1d44b09e654297b69d4bb3b6782dc1","type":"text","conversion_output":true,"text":"stimulation associated with laryngoscopy \\({ }^{63}\\).","text_display":" stimulation associated with laryngoscopy \\({ }^{63}\\).","confidence":0.99951171875,"confidence_rate":0.999991860024828},{"cnt":[[192,1215],[1825,1215],[1825,1266],[192,1266]],"region":{"top_left_x":191,"top_left_y":1215,"width":1635,"height":51},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1a291164a8ad4b0cbd7bc77d64569403","type":"text","conversion_output":true,"text":"Regarding propofol, the dose of \\(2.5 mg / kg\\) was used for intubation of the preterm infant with no","text_display":"\n\nRegarding propofol, the dose of \\(2.5 mg / kg\\) was used for intubation of the preterm infant with no","confidence":1,"confidence_rate":1},{"cnt":[[192,1275],[1862,1275],[1862,1332],[192,1332]],"region":{"top_left_x":191,"top_left_y":1274,"width":1671,"height":58},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8b87f377251b4d20a39a4d4db42eb531","type":"text","conversion_output":true,"text":"significant side effects, especially hemodynamic \\({ }^{51}\\). This study allowed a second injection of 2.5 mg","text_display":" significant side effects, especially hemodynamic \\({ }^{51}\\). This study allowed a second injection of 2.5 mg","confidence":1,"confidence_rate":1},{"cnt":[[190,1343],[1766,1343],[1766,1396],[190,1396]],"region":{"top_left_x":189,"top_left_y":1343,"width":1577,"height":53},"line":19,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"747d84a3217242208f7026a4b4f66b85","type":"text","conversion_output":true,"text":"/ kg in case of failure of the first dose, which was necessary in \\(24 \\%\\) of cases \\({ }^{64}\\). In addition, a","text_display":" / kg in case of failure of the first dose, which was necessary in \\(24 \\%\\) of cases \\({ }^{64}\\). In addition, a","confidence":0.985399927245453,"confidence_rate":0.9998732174970224},{"cnt":[[192,1412],[1859,1412],[1859,1464],[192,1464]],"region":{"top_left_x":191,"top_left_y":1411,"width":1669,"height":54},"line":20,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"aa8ef603d6644c9aad42c0aabfa622cf","type":"text","conversion_output":true,"text":"pharmacological study in the term and premature newborn showed that a single injection of \\(3 mg /\\)","text_display":" pharmacological study in the term and premature newborn showed that a single injection of \\(3 mg /\\)","confidence":0.9752426147460938,"confidence_rate":0.9997518228475633},{"cnt":[[192,1471],[1848,1471],[1848,1528],[192,1528]],"region":{"top_left_x":191,"top_left_y":1471,"width":1658,"height":58},"line":21,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7a8fbcc0250a4405b68bd9c57cda6794","type":"text","conversion_output":true,"text":"kg resulted in rapid elimination of the product \\({ }^{65}\\). This same study established a slower elimination","text_display":" kg resulted in rapid elimination of the product \\({ }^{65}\\). This same study established a slower elimination","confidence":0.97216796875,"confidence_rate":0.9997566961368488},{"cnt":[[192,1544],[1862,1544],[1862,1594],[192,1594]],"region":{"top_left_x":191,"top_left_y":1544,"width":1671,"height":51},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"66ede04a905743449f2bf48b0032f990","type":"text","conversion_output":true,"text":"of the product in premature infants and children less than 10 days old. However, the occurrence of","text_display":" of the product in premature infants and children less than 10 days old. However, the occurrence of","confidence":0.98046875,"confidence_rate":0.9998139370727239},{"cnt":[[192,1610],[1862,1610],[1862,1661],[192,1661]],"region":{"top_left_x":191,"top_left_y":1610,"width":1671,"height":51},"line":23,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"838e03dbf46545e2ba0d21e15f2550fc","type":"text","conversion_output":true,"text":"spontaneously resolving hypotension has been reported at a dose of \\(1 mg / kg\\) in children younger","text_display":" spontaneously resolving hypotension has been reported at a dose of \\(1 mg / kg\\) in children younger","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[192,1670],[1839,1670],[1839,1725],[192,1725]],"region":{"top_left_x":191,"top_left_y":1669,"width":1648,"height":56},"line":24,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b7e17a20dc1c4bfd80e0332007bc9c07","type":"text","conversion_output":true,"text":"than 8 hours \\({ }^{54}\\). Therefore, for the current study, a dose of \\(1 mg / kg\\) is proposed, ie \\(0.1 ml / kg\\) of","text_display":" than 8 hours \\({ }^{54}\\). Therefore, for the current study, a dose of \\(1 mg / kg\\) is proposed, ie \\(0.1 ml / kg\\) of","confidence":1,"confidence_rate":1},{"cnt":[[192,1741],[1866,1741],[1866,1793],[192,1793]],"region":{"top_left_x":191,"top_left_y":1740,"width":1676,"height":54},"line":25,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d9ad96c50b534a8dae387ae85339c6c6","type":"text","conversion_output":true,"text":"propofol 1\\% in infants under 1000 g and \\(2.5 mg / kg\\), ie \\(0.25 ml / kg\\) of propofol 1\\% in children over","text_display":" propofol 1\\% in infants under 1000 g and \\(2.5 mg / kg\\), ie \\(0.25 ml / kg\\) of propofol 1\\% in children over","confidence":0.7046328192109286,"confidence_rate":0.9971578803473757},{"cnt":[[192,1809],[1830,1809],[1830,1857],[192,1857]],"region":{"top_left_x":191,"top_left_y":1809,"width":1639,"height":49},"line":26,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"881e844f0a5e4f41b0091d02f5f288eb","type":"text","conversion_output":true,"text":"1000 g , slow IV over 1 minute. If a satisfactory sedation (see criteria in chapter \"Methods\") is not","text_display":" 1000 g , slow IV over 1 minute. If a satisfactory sedation (see criteria in chapter \"Methods\") is not","confidence":1,"confidence_rate":1},{"cnt":[[192,1873],[1857,1873],[1857,1926],[192,1926]],"region":{"top_left_x":191,"top_left_y":1873,"width":1667,"height":53},"line":27,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c2550da09bb5475fab4a5178eec04927","type":"text","conversion_output":true,"text":"obtained an additional dose of \\(1 mg / kg\\) (ie \\(3.5 mg / kg\\) maximum cumulative dose), or \\(0.1 ml / kg\\),","text_display":" obtained an additional dose of \\(1 mg / kg\\) (ie \\(3.5 mg / kg\\) maximum cumulative dose), or \\(0.1 ml / kg\\),","confidence":1,"confidence_rate":1},{"cnt":[[192,1942],[1875,1942],[1875,1990],[192,1990]],"region":{"top_left_x":191,"top_left_y":1941,"width":1685,"height":49},"line":28,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"aa335bd6f74e44018867d726b610e9f0","type":"text","conversion_output":true,"text":"may be administered. Propofol \\(1 \\%\\) will be increased to a volume of 1 ml in children under 1000 g to","text_display":" may be administered. Propofol \\(1 \\%\\) will be increased to a volume of 1 ml in children under 1000 g to","confidence":0.81298828125,"confidence_rate":0.9982167764586692},{"cnt":[[192,2006],[1492,2006],[1492,2056],[192,2056]],"region":{"top_left_x":191,"top_left_y":2005,"width":1301,"height":51},"line":29,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"27f6ef93e6be4c118103b4e5c5aa5215","type":"text","conversion_output":true,"text":"allow injection over 60 seconds. It will be used pure for children over 1000 g .","text_display":" allow injection over 60 seconds. It will be used pure for children over 1000 g .","confidence":0.998046875,"confidence_rate":0.9999789783410032},{"cnt":[[315,2070],[1862,2070],[1862,2122],[315,2122]],"region":{"top_left_x":315,"top_left_y":2069,"width":1547,"height":54},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"22b8b763e5ba454a9056c5b23f6d963e","type":"text","conversion_output":true,"text":"If a patient is randomized to the atropine-sufentanil-atracurium group, he or she will receive","text_display":"\n\nIf a patient is randomized to the atropine-sufentanil-atracurium group, he or she will receive","confidence":1,"confidence_rate":1},{"cnt":[[192,2138],[1834,2138],[1834,2186],[192,2186]],"region":{"top_left_x":191,"top_left_y":2138,"width":1644,"height":49},"line":31,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"aa2de6e1265b497988a02aa37c583ea2","type":"text","conversion_output":true,"text":"atracurium after atropine to prevent the risk of sufentanil-related chest rigidity. A dose of \\(0.3 mg /\\)","text_display":" atracurium after atropine to prevent the risk of sufentanil-related chest rigidity. A dose of \\(0.3 mg /\\)","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[192,2202],[1853,2202],[1853,2255],[192,2255]],"region":{"top_left_x":191,"top_left_y":2202,"width":1662,"height":53},"line":32,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8f5fc800c44049fcbd83fa562612aabc","type":"text","conversion_output":true,"text":"kg of atracurium will be used. The dose of \\(0.5 mg / kg\\) has been shown to be effective in neonates","text_display":" kg of atracurium will be used. The dose of \\(0.5 mg / kg\\) has been shown to be effective in neonates","confidence":0.87060546875,"confidence_rate":0.9987410988245237},{"cnt":[[192,2262],[1720,2262],[1720,2319],[192,2319]],"region":{"top_left_x":191,"top_left_y":2261,"width":1530,"height":58},"line":33,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c75eab36387941debb8aef678e8ef2ad","type":"text","conversion_output":true,"text":"\\({ }^{66,67}\\), as is the dose of \\(0.3 mg / kg\\) in only 10 patients \\({ }^{67}\\). Efficient dose-finding studies have","text_display":" \\({ }^{66,67}\\), as is the dose of \\(0.3 mg / kg\\) in only 10 patients \\({ }^{67}\\). Efficient dose-finding studies have","confidence":1,"confidence_rate":1},{"cnt":[[192,2328],[1837,2328],[1837,2385],[192,2385]],"region":{"top_left_x":191,"top_left_y":2327,"width":1646,"height":58},"line":34,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f9cd7b040a3f484388d9c6fa68f290dc","type":"text","conversion_output":true,"text":"established an effective dose range of 0.3 to \\(0.7 mg / kg\\) in neonates \\({ }^{68,69}\\). Finally, the occurrence","text_display":" established an effective dose range of 0.3 to \\(0.7 mg / kg\\) in neonates \\({ }^{68,69}\\). Finally, the occurrence","confidence":1,"confidence_rate":1},{"cnt":[[192,2394],[1848,2394],[1848,2451],[192,2451]],"region":{"top_left_x":191,"top_left_y":2394,"width":1658,"height":58},"line":35,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a3bf2776db8d443c86721fb35ab0e7f3","type":"text","conversion_output":true,"text":"of rare accidents in the United Kingdom has recommended a dose of \\(0.25 mg / kg\\) in newborns \\({ }^{70}\\).","text_display":" of rare accidents in the United Kingdom has recommended a dose of \\(0.25 mg / kg\\) in newborns \\({ }^{70}\\).","confidence":0.9990234375,"confidence_rate":0.9999915772798866},{"cnt":[[192,2467],[1839,2467],[1839,2517],[192,2517]],"region":{"top_left_x":191,"top_left_y":2467,"width":1648,"height":51},"line":36,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9e31a572023a4f3fa564fe45b03f6fbf","type":"text","conversion_output":true,"text":"We propose for this study a dose of \\(0.3 mg / kg\\) corresponding to the local experience at Créteil's","text_display":" We propose for this study a dose of \\(0.3 mg / kg\\) corresponding to the local experience at Créteil's","confidence":1,"confidence_rate":1},{"cnt":[[192,2527],[1848,2527],[1848,2584],[192,2584]],"region":{"top_left_x":191,"top_left_y":2526,"width":1658,"height":58},"line":37,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"eb5432893bc5427f9d69700a9045473f","type":"text","conversion_output":true,"text":"\\(NICU ^{50}\\). The atracurium besilate will be diluted according to the following modality: \\(1 ml =10 mg\\) in","text_display":" \\(NICU ^{50}\\). The atracurium besilate will be diluted according to the following modality: \\(1 ml =10 mg\\) in","confidence":1,"confidence_rate":1},{"cnt":[[192,2597],[1761,2597],[1761,2648],[192,2648]],"region":{"top_left_x":191,"top_left_y":2597,"width":1571,"height":51},"line":38,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"96df06599ed648bc85eae5d5c94a2d1a","type":"text","conversion_output":true,"text":"9 ml of D5\\% resulting in a solution diluted to \\(1 ml =1 mg .0 .3 ml / kg\\) (ie \\(0.3 mg / kg\\) ) of the IV","text_display":" 9 ml of D5\\% resulting in a solution diluted to \\(1 ml =1 mg .0 .3 ml / kg\\) (ie \\(0.3 mg / kg\\) ) of the IV","confidence":0.9951226694975048,"confidence_rate":0.999958566421992},{"cnt":[[1841,2755],[1878,2755],[1878,2794],[1841,2794]],"region":{"top_left_x":1841,"top_left_y":2754,"width":37,"height":40},"line":39,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"70cd9412381c43469379fc10b6b8d4b1","type":"page_info","conversion_output":false,"text":"o","text_display":"","confidence":0.3558838367462158,"confidence_rate":0.841817682646675}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-10","page":10,"lines":[{"cnt":[[192,151],[1853,151],[1853,194],[192,194]],"region":{"top_left_x":191,"top_left_y":150,"width":1662,"height":45},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"6ecbc661f285485d88217e1532453cf3","type":"text","conversion_output":true,"text":"diluted solution over 30 seconds will therefore be administered. In case of insufficient sedation, an","text_display":"\ndiluted solution over 30 seconds will therefore be administered. In case of insufficient sedation, an","confidence":1,"confidence_rate":1},{"cnt":[[192,215],[1843,215],[1843,263],[192,263]],"region":{"top_left_x":191,"top_left_y":214,"width":1653,"height":49},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"5acf97dbc6d949418ed634df9c5ff5a7","type":"text","conversion_output":true,"text":"additional dose of \\(0.1 ml / kg\\) (ie \\(0.1 mg / kg\\) ) may be administered after the injection of sufentanil.","text_display":" additional dose of \\(0.1 ml / kg\\) (ie \\(0.1 mg / kg\\) ) may be administered after the injection of sufentanil.","confidence":0.99951171875,"confidence_rate":0.9999959300041316},{"cnt":[[192,283],[1812,283],[1812,327],[192,327]],"region":{"top_left_x":191,"top_left_y":283,"width":1621,"height":44},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"371de991ab364b53b6e0468974dfb6b2","type":"text","conversion_output":true,"text":"Finally sufentanil will be injected. The loading dose of \\(0.2 \\mu g / kg\\) has been reported twice in the","text_display":" Finally sufentanil will be injected. The loading dose of \\(0.2 \\mu g / kg\\) has been reported twice in the","confidence":1,"confidence_rate":1},{"cnt":[[192,340],[1848,340],[1848,393],[192,393]],"region":{"top_left_x":191,"top_left_y":340,"width":1658,"height":53},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f01d36df01474407ba7189219409b2d7","type":"text","conversion_output":true,"text":"literature in neonates \\({ }^{71,72}\\), with both efficacy and good tolerance. In addition, it is regularly used in","text_display":" literature in neonates \\({ }^{71,72}\\), with both efficacy and good tolerance. In addition, it is regularly used in","confidence":1,"confidence_rate":1},{"cnt":[[192,407],[1834,407],[1834,459],[192,459]],"region":{"top_left_x":191,"top_left_y":406,"width":1644,"height":54},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"5b79a8c4b03a49edba8745a320eb6126","type":"text","conversion_output":true,"text":"Créteil's NICU \\({ }^{50}\\). Very high doses ( 5 to \\(15 \\mu g / kg\\) ) were administered in neonatal cardiac surgery","text_display":" Créteil's NICU \\({ }^{50}\\). Very high doses ( 5 to \\(15 \\mu g / kg\\) ) were administered in neonatal cardiac surgery","confidence":0.9956073760986328,"confidence_rate":0.9999650617229014},{"cnt":[[192,480],[1857,480],[1857,525],[192,525]],"region":{"top_left_x":191,"top_left_y":479,"width":1667,"height":47},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e3d6456b4f9546f098b1ad3b3011cd78","type":"text","conversion_output":true,"text":"with good tolerability and improvement in operative follow-up compared to the morphine-halothane","text_display":" with good tolerability and improvement in operative follow-up compared to the morphine-halothane","confidence":1,"confidence_rate":1},{"cnt":[[192,539],[1748,539],[1748,592],[192,592]],"region":{"top_left_x":191,"top_left_y":539,"width":1557,"height":53},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"552a5741ea3e467499a8c3bffee03b8f","type":"text","conversion_output":true,"text":"group \\({ }^{73}\\). However, in view of the pharmacokinetic peculiarities of extremely low birth weight","text_display":" group \\({ }^{73}\\). However, in view of the pharmacokinetic peculiarities of extremely low birth weight","confidence":1,"confidence_rate":1},{"cnt":[[192,612],[1862,612],[1862,660],[192,660]],"region":{"top_left_x":191,"top_left_y":612,"width":1671,"height":49},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"009b2d3a52fa40d8be4de7dd6aaaa7e7","type":"text","conversion_output":true,"text":"neonates, a dose of \\(0.1 \\mu g / kg\\) should be used in infants \\(<1000 g\\) and \\(0.2 \\mu g / kg\\) in infants \\(>1000\\)","text_display":" neonates, a dose of \\(0.1 \\mu g / kg\\) should be used in infants \\(<1000 g\\) and \\(0.2 \\mu g / kg\\) in infants \\(>1000\\)","confidence":0.9990236759185791,"confidence_rate":0.999991791621956},{"cnt":[[192,676],[1793,676],[1793,724],[192,724]],"region":{"top_left_x":191,"top_left_y":676,"width":1603,"height":49},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"184e2f97ca5f4eeb9b6cf9b98b9a6f1b","type":"text","conversion_output":true,"text":"g . Sufentanil will first be diluted according to the following scheme: dilute \\(1 ml =5 \\mu g\\) in 4 ml of","text_display":" g . Sufentanil will first be diluted according to the following scheme: dilute \\(1 ml =5 \\mu g\\) in 4 ml of","confidence":0.6806187971960753,"confidence_rate":0.9967446922554137},{"cnt":[[192,742],[1752,742],[1752,788],[192,788]],"region":{"top_left_x":191,"top_left_y":742,"width":1562,"height":47},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"76fde2bf495a4e70a515a44532642011","type":"text","conversion_output":true,"text":"D5\\% resulting in a solution diluted to \\(1 ml =1 \\mu g .0 .1\\) or \\(0.2 ml / kg (0.1\\) or \\(0.2 \\mu g / kg )\\) of the","text_display":" D5\\% resulting in a solution diluted to \\(1 ml =1 \\mu g .0 .1\\) or \\(0.2 ml / kg (0.1\\) or \\(0.2 \\mu g / kg )\\) of the","confidence":0.9534651175253079,"confidence_rate":0.9995962473078309},{"cnt":[[192,809],[1862,809],[1862,854],[192,854]],"region":{"top_left_x":191,"top_left_y":808,"width":1671,"height":47},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f876b2c68f044c3ea2eec2aff9cecfa1","type":"text","conversion_output":true,"text":"diluted IV solution will be administered depending on the weight groups over 60 seconds to reduce","text_display":" diluted IV solution will be administered depending on the weight groups over 60 seconds to reduce","confidence":1,"confidence_rate":1},{"cnt":[[192,873],[1725,873],[1725,921],[192,921]],"region":{"top_left_x":191,"top_left_y":872,"width":1534,"height":49},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d84989fe341b4b07ad371bc77aca0e08","type":"text","conversion_output":true,"text":"the risk of thoracic rigidity. In the group of infants \\(<1000 g\\), the volume of the syringe will be","text_display":" the risk of thoracic rigidity. In the group of infants \\(<1000 g\\), the volume of the syringe will be","confidence":0.9970703125,"confidence_rate":0.9999728338186853},{"cnt":[[192,941],[1757,941],[1757,989],[192,989]],"region":{"top_left_x":191,"top_left_y":941,"width":1566,"height":49},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f95f43ce90244ff4a9bfcf75e86495f2","type":"text","conversion_output":true,"text":"increased to 1 ml to allow injection over 60 seconds. In infants> 1000 g , the drug will be used","text_display":" increased to 1 ml to allow injection over 60 seconds. In infants> 1000 g , the drug will be used","confidence":0.9707438945770264,"confidence_rate":0.9997395725155673},{"cnt":[[192,1007],[1090,1007],[1090,1053],[192,1053]],"region":{"top_left_x":191,"top_left_y":1007,"width":899,"height":47},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d562dea210c347f4a20ff901300a49b2","type":"text","conversion_output":true,"text":"diluted according to the above-mentioned modalities.","text_display":" diluted according to the above-mentioned modalities.","confidence":1,"confidence_rate":1},{"cnt":[[315,1071],[1834,1071],[1834,1117],[315,1117]],"region":{"top_left_x":315,"top_left_y":1071,"width":1520,"height":47},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a51165b05f1947d2b8189baaf603bc2d","type":"text","conversion_output":true,"text":"With regard to the placebo for the studied drugs, the volumes of normal saline used in the","text_display":"\n\nWith regard to the placebo for the studied drugs, the volumes of normal saline used in the","confidence":0.9990234375,"confidence_rate":0.9999897154250147},{"cnt":[[192,1138],[1843,1138],[1843,1186],[192,1186]],"region":{"top_left_x":191,"top_left_y":1137,"width":1653,"height":49},"line":16,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a37a0c042b624ab185e62780691176ab","type":"text","conversion_output":true,"text":"propofol arm ( 0.5 ml maximum cumulative volume in children \\(<1000 g\\) and \\(0.6 ml / kg\\) in children>","text_display":" propofol arm ( 0.5 ml maximum cumulative volume in children \\(<1000 g\\) and \\(0.6 ml / kg\\) in children>","confidence":0.8539296055678278,"confidence_rate":0.998651281982623},{"cnt":[[194,1202],[1869,1202],[1869,1250],[194,1250]],"region":{"top_left_x":194,"top_left_y":1201,"width":1675,"height":49},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"742554366a174283b15a86c1c51d8502","type":"text","conversion_output":true,"text":"1000 g ) are considered negligible and without any effect on the blood volume or ionogram because","text_display":" 1000 g ) are considered negligible and without any effect on the blood volume or ionogram because","confidence":0.9819583813659847,"confidence_rate":0.9998232549122553},{"cnt":[[192,1270],[1841,1270],[1841,1318],[192,1318]],"region":{"top_left_x":191,"top_left_y":1270,"width":1651,"height":49},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2f6ed7cc3e554e08935a1dc503a5d827","type":"text","conversion_output":true,"text":"they are lower than the flushing volumes currently used in daily practice. The volume of intralipids","text_display":" they are lower than the flushing volumes currently used in daily practice. The volume of intralipids","confidence":1,"confidence_rate":1},{"cnt":[[192,1334],[1869,1334],[1869,1382],[192,1382]],"region":{"top_left_x":191,"top_left_y":1334,"width":1678,"height":49},"line":19,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"eb72c7832bb44dca98047fe330bdc519","type":"text","conversion_output":true,"text":"\\(20 \\%\\) used in the sufentanil + atracurium arm represents a maximum of \\(0.2 ml / kg (<1000 g)\\) or 0.35","text_display":" \\(20 \\%\\) used in the sufentanil + atracurium arm represents a maximum of \\(0.2 ml / kg (<1000 g)\\) or 0.35","confidence":0.8777465940814827,"confidence_rate":0.9988152719430259},{"cnt":[[192,1400],[1857,1400],[1857,1451],[192,1451]],"region":{"top_left_x":191,"top_left_y":1400,"width":1667,"height":51},"line":20,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"51a84eba1ee84740851a44d97f517272","type":"text","conversion_output":true,"text":"\\(ml / kg (>1000 g)\\) cumulative volume. These intakes correspond respectively to \\(0.04 g / kg (<1000\\)","text_display":" \\(ml / kg (>1000 g)\\) cumulative volume. These intakes correspond respectively to \\(0.04 g / kg (<1000","confidence":0.9897718266583979,"confidence_rate":0.9999030156415842},{"cnt":[[192,1467],[1752,1467],[1752,1515],[192,1515]],"region":{"top_left_x":191,"top_left_y":1466,"width":1562,"height":49},"line":21,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a3ac9fcb302043ea905b9de857ad9351","type":"text","conversion_output":true,"text":"\\(g )\\) and \\(0.07 g / kg\\) of purified soybean oil. These minimal intakes do not affect global nutrient","text_display":" g )\\) and \\(0.07 g / kg\\) of purified soybean oil. These minimal intakes do not affect global nutrient","confidence":0.5567032005637884,"confidence_rate":0.9945913184427019},{"cnt":[[192,1531],[1021,1531],[1021,1579],[192,1579]],"region":{"top_left_x":191,"top_left_y":1530,"width":831,"height":49},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"22bc7d83fe024738bc052ea907ac0323","type":"text","conversion_output":true,"text":"intakes of the order of 2 to \\(3 g / kg / 24 h\\) of lipids.","text_display":" intakes of the order of 2 to \\(3 g / kg / 24 h\\) of lipids.","confidence":1,"confidence_rate":1},{"cnt":[[187,1700],[1798,1700],[1798,1814],[187,1814]],"region":{"top_left_x":187,"top_left_y":1699,"width":1611,"height":115},"line":23,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"3922b041b4694afc820675eb6644a2d0","type":"section_header","conversion_output":false,"children_ids":["170167feebe745fa8523b36d68885734","f3fdc015ee6d43a989726b036bf78218"],"text":"","text_display":""},{"cnt":[[194,1704],[1793,1704],[1793,1752],[194,1752]],"region":{"top_left_x":194,"top_left_y":1704,"width":1600,"height":49},"line":24,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"170167feebe745fa8523b36d68885734","type":"text","conversion_output":true,"parent_id":"3922b041b4694afc820675eb6644a2d0","text":"Declaration of compliance with the protocol, good clinical practices and the legal and","text_display":"\n\n\\section*{Declaration of compliance with the protocol, good clinical practices and the legal and","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[192,1759],[747,1759],[747,1807],[192,1807]],"region":{"top_left_x":191,"top_left_y":1758,"width":556,"height":49},"line":25,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"f3fdc015ee6d43a989726b036bf78218","type":"text","conversion_output":true,"parent_id":"3922b041b4694afc820675eb6644a2d0","text":"regulatory provisions in force","text_display":" regulatory provisions in force}","confidence":0.998046875,"confidence_rate":0.9999441434218709},{"cnt":[[192,1878],[1862,1878],[1862,1921],[192,1921]],"region":{"top_left_x":191,"top_left_y":1877,"width":1671,"height":45},"line":26,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"10e387622717417cab91de2e0f48191e","type":"text","conversion_output":true,"text":"The participating investigators undertake to respect the study protocol and to comply with the good","text_display":"\n\nThe participating investigators undertake to respect the study protocol and to comply with the good","confidence":1,"confidence_rate":1},{"cnt":[[192,1942],[1624,1942],[1624,1987],[192,1987]],"region":{"top_left_x":191,"top_left_y":1941,"width":1434,"height":47},"line":27,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"32c942eaf6ab4512aa64f6c36036cd24","type":"text","conversion_output":true,"text":"practices in force. The legal and regulatory provisions in force will also be respected.","text_display":" practices in force. The legal and regulatory provisions in force will also be respected.","confidence":1,"confidence_rate":1},{"cnt":[[192,2006],[1722,2006],[1722,2054],[192,2054]],"region":{"top_left_x":191,"top_left_y":2005,"width":1532,"height":49},"line":28,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"83c3bf831fdd430f82659850bfd0abfd","type":"text","conversion_output":true,"text":"The choice of the atropine-opioid-neuromuscular blocker combination for the control group","text_display":"\n\nThe choice of the atropine-opioid-neuromuscular blocker combination for the control group","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[192,2065],[1789,2065],[1789,2122],[192,2122]],"region":{"top_left_x":191,"top_left_y":2065,"width":1598,"height":58},"line":29,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8394af5fa9bd4ff09e17b5d50146c592","type":"text","conversion_output":true,"text":"corresponds to the recommendations of the literature \\(14,18,23\\). The choice of atropine-propofol is","text_display":" corresponds to the recommendations of the literature \\(14,18,23\\). The choice of atropine-propofol is","confidence":0.6201171875,"confidence_rate":0.9955021569873971},{"cnt":[[192,2131],[1711,2131],[1711,2186],[192,2186]],"region":{"top_left_x":191,"top_left_y":2131,"width":1520,"height":56},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f017e2d91d424a93ab5ef41f2f3b1e05","type":"text","conversion_output":true,"text":"based on the pharmacological properties of propofol and the encouraging literature \\({ }^{51,55,56}\\).","text_display":" based on the pharmacological properties of propofol and the encouraging literature \\({ }^{51,55,56}\\).","confidence":0.99365234375,"confidence_rate":0.9999410398096767},{"cnt":[[192,2307],[1012,2307],[1012,2360],[192,2360]],"region":{"top_left_x":191,"top_left_y":2307,"width":821,"height":53},"line":31,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"9efb2c7be0104156b0a503bc4717add8","type":"section_header","conversion_output":false,"children_ids":["b406f547b9ff432ca034ec5dd4150cb5"],"text":"","text_display":""},{"cnt":[[194,2312],[1007,2312],[1007,2360],[194,2360]],"region":{"top_left_x":194,"top_left_y":2311,"width":814,"height":49},"line":32,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"b406f547b9ff432ca034ec5dd4150cb5","type":"text","conversion_output":true,"parent_id":"9efb2c7be0104156b0a503bc4717add8","text":"Description of the population to be studied","text_display":"\n\n\\section*{Description of the population to be studied}","confidence":1,"confidence_rate":1},{"cnt":[[192,2410],[1775,2410],[1775,2456],[192,2456]],"region":{"top_left_x":191,"top_left_y":2410,"width":1584,"height":46},"line":33,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b3083582e11741d98120b2cafdaec3e6","type":"text","conversion_output":true,"text":"The study will include all premature or term neonates requiring tracheal intubation outside the","text_display":"\n\nThe study will include all premature or term neonates requiring tracheal intubation outside the","confidence":1,"confidence_rate":1},{"cnt":[[192,2476],[1780,2476],[1780,2524],[192,2524]],"region":{"top_left_x":191,"top_left_y":2476,"width":1589,"height":49},"line":34,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c5d0c8e5b9454a72be480efe6f589c61","type":"text","conversion_output":true,"text":"context of the vital emergency and not presenting a contraindication to the use of the different","text_display":" context of the vital emergency and not presenting a contraindication to the use of the different","confidence":1,"confidence_rate":1},{"cnt":[[192,2540],[1784,2540],[1784,2588],[192,2588]],"region":{"top_left_x":191,"top_left_y":2540,"width":1594,"height":49},"line":35,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"edba1c4bae644c389fc061e57caaee76","type":"text","conversion_output":true,"text":"experimental treatments (see criteria for non-inclusion). These children will be divided into two","text_display":" experimental treatments (see criteria for non-inclusion). These children will be divided into two","confidence":1,"confidence_rate":1},{"cnt":[[192,2609],[1158,2609],[1158,2652],[192,2652]],"region":{"top_left_x":191,"top_left_y":2608,"width":968,"height":45},"line":36,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"5736cb1161904b3db29d4dbcb05d9c10","type":"text","conversion_output":true,"text":"groups according to their weight at the time of intubation.","text_display":" groups according to their weight at the time of intubation.","confidence":1,"confidence_rate":1},{"cnt":[[1823,2755],[1878,2755],[1878,2794],[1823,2794]],"region":{"top_left_x":1822,"top_left_y":2754,"width":56,"height":40},"line":37,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"3d46f9ea13f64f43a3b4db6b13ab34e7","type":"page_info","conversion_output":false,"text":"10","text_display":"","confidence":0.6470651626586914,"confidence_rate":0.804403606816063}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-11","page":11,"lines":[{"cnt":[[1823,2755],[1869,2755],[1869,2789],[1823,2789]],"region":{"top_left_x":1822,"top_left_y":2754,"width":47,"height":36},"line":1,"column":0,"font_size":23,"is_printed":true,"is_handwritten":false,"id":"47a8728dd6b14808a3e5331674bad381","type":"page_info","conversion_output":false,"text":"\\(11\\)","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-12","page":12,"lines":[{"cnt":[[185,302],[733,302],[733,372],[185,372]],"region":{"top_left_x":185,"top_left_y":301,"width":549,"height":72},"line":1,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"7bfcffa7919c47f1ab299e905e6da52d","type":"section_header","conversion_output":false,"children_ids":["0a79419f45a74cd1b939a5e5c48071a3"],"text":"","text_display":""},{"cnt":[[192,306],[729,306],[729,368],[192,368]],"region":{"top_left_x":191,"top_left_y":306,"width":538,"height":62},"line":2,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"0a79419f45a74cd1b939a5e5c48071a3","type":"text","conversion_output":true,"parent_id":"7bfcffa7919c47f1ab299e905e6da52d","text":"Purpose 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aim is to compare two premedications: atropine-propofol and atropine-atracurium-sufentanil","text_display":"\n\nThe aim is to compare two premedications: atropine-propofol and atropine-atracurium-sufentanil","confidence":1,"confidence_rate":1},{"cnt":[[192,605],[1807,605],[1807,653],[192,653]],"region":{"top_left_x":191,"top_left_y":605,"width":1616,"height":49},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"4844415f1821455f99043d4fce41981c","type":"text","conversion_output":true,"text":"regarding desaturationsduring neonatal tracheal intubation on one hand, and regarding efficacy","text_display":" regarding desaturationsduring neonatal tracheal intubation on one hand, and regarding 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In case of intubation in an eligible infant with signed parental consent, the","text_display":" be given to the parents. In case of intubation in an eligible infant with signed parental consent, the","confidence":1,"confidence_rate":1},{"cnt":[[192,1978],[1757,1978],[1757,2024],[192,2024]],"region":{"top_left_x":191,"top_left_y":1978,"width":1566,"height":46},"line":29,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"800e3be0c93042d8a736b5721feb3217","type":"text","conversion_output":true,"text":"child will be included in the study and the parents will be notified according to the usual local","text_display":" child will be included in the study and the parents will be notified according to the usual local","confidence":1,"confidence_rate":1},{"cnt":[[192,2042],[1330,2042],[1330,2090],[192,2090]],"region":{"top_left_x":191,"top_left_y":2042,"width":1139,"height":49},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"19fb0b009b5c4da8ad59f13fbc8dbbfd","type":"text","conversion_output":true,"text":"practices (telephone call or interview, immediately or after a delay).","text_display":" practices (telephone call or interview, immediately or after a delay).","confidence":1,"confidence_rate":1},{"cnt":[[190,2147],[482,2147],[482,2195],[190,2195]],"region":{"top_left_x":189,"top_left_y":2147,"width":294,"height":49},"line":31,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"92cf02237c3d4e16bb9d27343f1b87e5","type":"section_header","conversion_output":false,"children_ids":["3d0e9496f19240448ccf93e427139672"],"text":"","text_display":""},{"cnt":[[194,2152],[480,2152],[480,2191],[194,2191]],"region":{"top_left_x":194,"top_left_y":2151,"width":286,"height":40},"line":32,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"3d0e9496f19240448ccf93e427139672","type":"text","conversion_output":true,"parent_id":"92cf02237c3d4e16bb9d27343f1b87e5","text":"Data collection","text_display":"\n\n\\section*{Data collection}","confidence":1,"confidence_rate":1},{"cnt":[[192,2248],[1841,2248],[1841,2296],[192,2296]],"region":{"top_left_x":191,"top_left_y":2247,"width":1651,"height":49},"line":33,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7874a00730344659b9624f753d5ab8c0","type":"text","conversion_output":true,"text":"A team member who will not be directly involved in the intubation procedure will be designated as","text_display":"\n\nA team member who will not be directly involved in the intubation procedure will be designated as","confidence":1,"confidence_rate":1},{"cnt":[[192,2316],[1318,2316],[1318,2360],[192,2360]],"region":{"top_left_x":191,"top_left_y":2316,"width":1128,"height":44},"line":34,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0c3872f3e6bb4c97a77f0d6f77b15ee8","type":"text","conversion_output":true,"text":"an \"observer\". He/she will be responsible for the collection of data.","text_display":" an \"observer\". He/she will be responsible for the collection of data.","confidence":1,"confidence_rate":1},{"cnt":[[192,2380],[1761,2380],[1761,2428],[192,2428]],"region":{"top_left_x":191,"top_left_y":2380,"width":1571,"height":49},"line":35,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c1b6ce607bae4a1a9c12f4ef505f054b","type":"text","conversion_output":true,"text":"The child's birth date, age and corrected age, birth weight and current weight, sex, 5 minutes","text_display":"\n\nThe child's birth date, age and corrected age, birth weight and current weight, sex, 5 minutes","confidence":1,"confidence_rate":1},{"cnt":[[192,2444],[1857,2444],[1857,2492],[192,2492]],"region":{"top_left_x":191,"top_left_y":2444,"width":1667,"height":49},"line":36,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a26294b8dc924ad58e9389e7ed1b5e58","type":"text","conversion_output":true,"text":"Apgar score, reason for intubation, personal history of intubation and last cranial ultrasound will be","text_display":" Apgar score, reason for intubation, personal history of intubation and last cranial ultrasound will be","confidence":1,"confidence_rate":1},{"cnt":[[192,2513],[1823,2513],[1823,2556],[192,2556]],"region":{"top_left_x":191,"top_left_y":2512,"width":1632,"height":45},"line":37,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b27394753e7c43d79313ff771c36bf0d","type":"text","conversion_output":true,"text":"recorded before the start of the procedure. If the child had nocranial ultrasound performed within","text_display":" recorded before the start of the procedure. If the child had nocranial ultrasound performed within","confidence":1,"confidence_rate":1},{"cnt":[[192,2577],[1263,2577],[1263,2625],[192,2625]],"region":{"top_left_x":191,"top_left_y":2576,"width":1073,"height":49},"line":38,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2fe21018b10b48978d5e92182739936e","type":"text","conversion_output":true,"text":"the previous 7 days, one should be performed before inclusion.","text_display":" the previous 7 days, one should be performed before inclusion.","confidence":1,"confidence_rate":1},{"cnt":[[1823,2755],[1873,2755],[1873,2787],[1823,2787]],"region":{"top_left_x":1822,"top_left_y":2754,"width":52,"height":33},"line":39,"column":0,"font_size":23,"is_printed":true,"is_handwritten":false,"id":"b6a033f3b90e4c568641825c685b8cec","type":"page_info","conversion_output":false,"text":"12","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-14","page":14,"lines":[{"cnt":[[192,148],[1841,148],[1841,194],[192,194]],"region":{"top_left_x":191,"top_left_y":148,"width":1651,"height":47},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"966292080b7a4343be03bfcacc4f5b4e","type":"text","conversion_output":true,"text":"The collection of the physiological parameters will begin 1 minute before the first injection and will","text_display":"\n\nThe collection of the physiological parameters will begin 1 minute before the first injection and will","confidence":1,"confidence_rate":1},{"cnt":[[192,215],[1812,215],[1812,263],[192,263]],"region":{"top_left_x":191,"top_left_y":214,"width":1621,"height":49},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a514d95eb35a4cac990698b3f3f4f8ec","type":"text","conversion_output":true,"text":"be continued one hour after. Heart rate, pulse oximetry and blood pressure will be obtained one","text_display":" be continued one hour after. Heart rate, pulse oximetry and blood pressure will be obtained one","confidence":1,"confidence_rate":1},{"cnt":[[192,281],[1866,281],[1866,331],[192,331]],"region":{"top_left_x":191,"top_left_y":280,"width":1676,"height":52},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ad7dab67e73548dbb1e311da441269c3","type":"text","conversion_output":true,"text":"minute prior to injection of the first drug (atropine) and will be used as the baseline. Throughout the","text_display":" minute prior to injection of the first drug (atropine) and will be used as the baseline. Throughout the","confidence":1,"confidence_rate":1},{"cnt":[[192,347],[1834,347],[1834,395],[192,395]],"region":{"top_left_x":191,"top_left_y":347,"width":1644,"height":49},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8cefae5d6e234ddfb3968c14613b4abd","type":"text","conversion_output":true,"text":"procedure, heart rate, transcutaneous CO 2 partial pressure \\(( TcPCO 2)\\) and oxygen saturation will","text_display":" procedure, heart rate, transcutaneous CO 2 partial pressure \\(( TcPCO 2)\\) and oxygen saturation will","confidence":0.33978468272835016,"confidence_rate":0.9903224190703523},{"cnt":[[192,413],[1738,413],[1738,459],[192,459]],"region":{"top_left_x":191,"top_left_y":413,"width":1548,"height":47},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a1ea95f38d8a45cdac863bb58d9b136a","type":"text","conversion_output":true,"text":"be monitored continuously and blood pressure will be measured every three minutes by the","text_display":" be monitored continuously and blood pressure will be measured every three minutes by the","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[192,480],[1743,480],[1743,528],[192,528]],"region":{"top_left_x":191,"top_left_y":479,"width":1552,"height":49},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"dd0761aa9bf24202a8e62b5bc8ed3045","type":"text","conversion_output":true,"text":"monitoring system used in each service. O 2 saturation will be measured by oximeters using","text_display":" monitoring system used in each service. O 2 saturation will be measured by oximeters using","confidence":0.9585161209106445,"confidence_rate":0.9995764007660689},{"cnt":[[192,539],[1732,539],[1732,592],[192,592]],"region":{"top_left_x":191,"top_left_y":539,"width":1541,"height":53},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"05d604648e6f4f8baf0203f18a6e9bf6","type":"text","conversion_output":true,"text":"Masimo technology \\({ }^{74}\\) in all participating centers. Heart rate, blood pressure, O2 saturation,","text_display":" Masimo technology \\({ }^{74}\\) in all participating centers. Heart rate, blood pressure, O2 saturation,","confidence":0.56201171875,"confidence_rate":0.9946787216008613},{"cnt":[[192,612],[1862,612],[1862,660],[192,660]],"region":{"top_left_x":191,"top_left_y":612,"width":1671,"height":49},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"afc2237879d94613a95b48f515c6c527","type":"text","conversion_output":true,"text":"TcPCO2, cerebral activity via cerebral oximetry and ventilatory constants will be recorded 1 minute","text_display":" TcPCO2, cerebral activity via cerebral oximetry and ventilatory constants will be recorded 1 minute","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[192,676],[1748,676],[1748,724],[192,724]],"region":{"top_left_x":191,"top_left_y":676,"width":1557,"height":49},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f79b0c38049d45a5877f039af40c795e","type":"text","conversion_output":true,"text":"before the first injection, then \\(3,6,9,12,15,30,45\\) and 60 minutes after the start of the first","text_display":" before the first injection, then \\(3,6,9,12,15,30,45\\) and 60 minutes after the start of the first","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[192,745],[350,745],[350,788],[192,788]],"region":{"top_left_x":191,"top_left_y":744,"width":159,"height":45},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7869d02b000d4cc0a7c52c4f91bb27c2","type":"text","conversion_output":true,"text":"injection.","text_display":" injection.","confidence":1,"confidence_rate":1},{"cnt":[[192,809],[1862,809],[1862,854],[192,854]],"region":{"top_left_x":191,"top_left_y":808,"width":1671,"height":47},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"6ea77db9e31244e9b69bec093193f800","type":"text","conversion_output":true,"text":"The observer will collect vital parameters before the procedure and then, during the procedure, the","text_display":"\n\nThe observer will collect vital parameters before the procedure and then, during the procedure, the","confidence":1,"confidence_rate":1},{"cnt":[[192,873],[1766,873],[1766,921],[192,921]],"region":{"top_left_x":191,"top_left_y":872,"width":1575,"height":49},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a3f183f6443d419fbd84c020e328b236","type":"text","conversion_output":true,"text":"lowest heart rate, lowest saturation and the lowest and highest arterial pressures. He/she will","text_display":" lowest heart rate, lowest saturation and the lowest and highest arterial pressures. He/she will","confidence":1,"confidence_rate":1},{"cnt":[[192,941],[1843,941],[1843,989],[192,989]],"region":{"top_left_x":191,"top_left_y":941,"width":1653,"height":49},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"44103f0061f4410b8408d63fd9ce581d","type":"text","conversion_output":true,"text":"measure the duration of intubation, the recovery time of spontaneous ventilation and the recovery","text_display":" measure the duration of intubation, the recovery time of spontaneous ventilation and the recovery","confidence":0.9975595474243164,"confidence_rate":0.999976045038553},{"cnt":[[192,1005],[1843,1005],[1843,1053],[192,1053]],"region":{"top_left_x":191,"top_left_y":1005,"width":1653,"height":49},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"339750d7e3f94cee821a91999a28cfcf","type":"text","conversion_output":true,"text":"time of spontaneous movements after the first drug injection. By controlling on the central monitor","text_display":" time of spontaneous movements after the first drug injection. By controlling on the central monitor","confidence":1,"confidence_rate":1},{"cnt":[[192,1071],[1816,1071],[1816,1117],[192,1117]],"region":{"top_left_x":191,"top_left_y":1071,"width":1626,"height":47},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"af07556eda2c4110885f6d847c9e53a4","type":"text","conversion_output":true,"text":"recordings, he/she will confirm the occurrence of the primary outcome (desaturation of less than","text_display":" recordings, he/she will confirm the occurrence of the primary outcome (desaturation of less than","confidence":0.8173828125,"confidence_rate":0.99800547947602},{"cnt":[[192,1138],[1784,1138],[1784,1183],[192,1183]],"region":{"top_left_x":191,"top_left_y":1137,"width":1594,"height":47},"line":16,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a802121919e6481294a05e8c443bd931","type":"text","conversion_output":true,"text":"\\(80 \\%\\) for at least 60 seconds). This recording of physiological data will be stored and printed or","text_display":" \\(80 \\%\\) for at least 60 seconds). This recording of physiological data will be stored and printed or","confidence":0.99658203125,"confidence_rate":0.9999667595490823},{"cnt":[[192,1202],[1816,1202],[1816,1250],[192,1250]],"region":{"top_left_x":191,"top_left_y":1201,"width":1626,"height":49},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"81a6c970cbc6453c9b4699c24e2fed21","type":"text","conversion_output":true,"text":"saved in a digital format as source data. If no record can be made, the handwritten record sheet","text_display":" saved in a digital format as source data. If no record can be made, the handwritten record sheet","confidence":1,"confidence_rate":1},{"cnt":[[192,1270],[1085,1270],[1085,1318],[192,1318]],"region":{"top_left_x":191,"top_left_y":1270,"width":895,"height":49},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"72090b5e732f420fba8ea98c601436e9","type":"text","conversion_output":true,"text":"completed by the observer will serve as source data.","text_display":" completed by the observer will serve as source data.","confidence":1,"confidence_rate":1},{"cnt":[[192,1334],[1766,1334],[1766,1382],[192,1382]],"region":{"top_left_x":191,"top_left_y":1334,"width":1575,"height":49},"line":19,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"52754a23bb7a4f778461398ee88cfb42","type":"text","conversion_output":true,"text":"The time will be measured from the insertion at the last ablation of the laryngoscope form the","text_display":"\n\nThe time will be measured from the insertion at the last ablation of the laryngoscope form the","confidence":1,"confidence_rate":1},{"cnt":[[192,1403],[1757,1403],[1757,1448],[192,1448]],"region":{"top_left_x":191,"top_left_y":1402,"width":1566,"height":47},"line":20,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a7f6706ced0c448b99686d46d928d6e2","type":"text","conversion_output":true,"text":"mouth after the success of the intubation. Intubation will be considered successful by clinical","text_display":" mouth after the success of the intubation. Intubation will be considered successful by clinical","confidence":1,"confidence_rate":1},{"cnt":[[192,1467],[1830,1467],[1830,1515],[192,1515]],"region":{"top_left_x":191,"top_left_y":1466,"width":1639,"height":49},"line":21,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"df182edd5c9740d8a4478809d5fda765","type":"text","conversion_output":true,"text":"confirmation of bilateral lung sounds on auscultation, increased heart rate and saturation, and by","text_display":" confirmation of bilateral lung sounds on auscultation, increased heart rate and saturation, and by","confidence":1,"confidence_rate":1},{"cnt":[[192,1531],[1807,1531],[1807,1579],[192,1579]],"region":{"top_left_x":191,"top_left_y":1530,"width":1616,"height":49},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"3bf5e3f020104732860b4a98777d3fcc","type":"text","conversion_output":true,"text":"the presence of an inspiratory and expiratory curve obtained through the respirator's spirometry","text_display":" the presence of an inspiratory and expiratory curve obtained through the respirator's spirometry","confidence":1,"confidence_rate":1},{"cnt":[[192,1599],[1631,1599],[1631,1647],[192,1647]],"region":{"top_left_x":191,"top_left_y":1599,"width":1441,"height":49},"line":23,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"cd48719cf6774462b53f8d067b191bae","type":"text","conversion_output":true,"text":"sensor. In both groups, the duration of action of the drugs administered will be noted.","text_display":" sensor. In both groups, the duration of action of the drugs administered will be noted.","confidence":1,"confidence_rate":1},{"cnt":[[192,1665],[1784,1665],[1784,1711],[192,1711]],"region":{"top_left_x":191,"top_left_y":1665,"width":1594,"height":46},"line":24,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7b77572c78da45359cc88d85f0934111","type":"text","conversion_output":true,"text":"A standardized collection sheet will indicate the level of training of the operator, the number of","text_display":"\n\nA standardized collection sheet will indicate the level of training of the operator, the number of","confidence":1,"confidence_rate":1},{"cnt":[[192,1732],[1720,1732],[1720,1780],[192,1780]],"region":{"top_left_x":191,"top_left_y":1731,"width":1530,"height":49},"line":25,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0d9b0ce6ea5047d59200a712a56bec43","type":"text","conversion_output":true,"text":"attempts for each operator, the total number of attempts required and the existence of any","text_display":" attempts for each operator, the total number of attempts required and the existence of any","confidence":1,"confidence_rate":1},{"cnt":[[192,1796],[1419,1796],[1419,1843],[192,1843]],"region":{"top_left_x":191,"top_left_y":1795,"width":1228,"height":49},"line":26,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2a7d069410204a579df76b85e414019d","type":"text","conversion_output":true,"text":"complications such as thoracic stiffness, lacerations of the mouth or lips.","text_display":" complications such as thoracic stiffness, lacerations of the mouth or lips.","confidence":1,"confidence_rate":1},{"cnt":[[192,1859],[1752,1859],[1752,1910],[192,1910]],"region":{"top_left_x":191,"top_left_y":1859,"width":1562,"height":51},"line":27,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"19bb212a1477461cb74aa8f0efdcdefd","type":"text","conversion_output":true,"text":"For neurological surveillance, aHUS will be performed within 7 days of intubation and will be","text_display":"\n\nFor neurological surveillance, aHUS will be performed within 7 days of intubation and will be","confidence":1,"confidence_rate":1},{"cnt":[[192,1928],[1720,1928],[1720,1976],[192,1976]],"region":{"top_left_x":191,"top_left_y":1928,"width":1530,"height":48},"line":28,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"816b10219c5a4cae83f480acf11137fd","type":"text","conversion_output":true,"text":"compared to the pre-intubation examination if it exists. The follow-up of the children will be","text_display":" compared to the pre-intubation examination if it exists. The follow-up of the children will be","confidence":1,"confidence_rate":1},{"cnt":[[192,1994],[1752,1994],[1752,2040],[192,2040]],"region":{"top_left_x":191,"top_left_y":1994,"width":1562,"height":46},"line":29,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"3a3fb805e60540318201bbb89322f489","type":"text","conversion_output":true,"text":"performed in each unit during outpatient visits at the corrected ages of one and two years. A","text_display":" performed in each unit during outpatient visits at the corrected ages of one and two years. A","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[192,2061],[1679,2061],[1679,2108],[192,2108]],"region":{"top_left_x":191,"top_left_y":2060,"width":1489,"height":49},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"dd1f4deacdc44669b243ef57e682d98c","type":"text","conversion_output":true,"text":"questionnaire corresponding to the French version of the questionnaire Age and Stages","text_display":" questionnaire corresponding to the French version of the questionnaire Age and Stages","confidence":1,"confidence_rate":1},{"cnt":[[192,2120],[1823,2120],[1823,2172],[192,2172]],"region":{"top_left_x":191,"top_left_y":2119,"width":1632,"height":54},"line":31,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"51f2083700fe4df5a94da8c120de7e70","type":"text","conversion_output":true,"text":"Questionnaire (ASQ) \\({ }^{75}\\) will then be completed. In the absence of outpatient visits, parents will be","text_display":" Questionnaire (ASQ) \\({ }^{75}\\) will then be completed. In the absence of outpatient visits, parents will be","confidence":1,"confidence_rate":1},{"cnt":[[192,2188],[1656,2188],[1656,2239],[192,2239]],"region":{"top_left_x":191,"top_left_y":2188,"width":1466,"height":51},"line":32,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d37c9041984f428eb338c4f32a1566e1","type":"text","conversion_output":true,"text":"called by telephone at the same dates and asked to complete the same questionnaire.","text_display":" called by telephone at the same dates and asked to complete the same questionnaire.","confidence":1,"confidence_rate":1},{"cnt":[[187,2291],[441,2291],[441,2346],[187,2346]],"region":{"top_left_x":187,"top_left_y":2291,"width":254,"height":56},"line":33,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"b08ab0bdbf0d4f159d5e7e3496dd2aad","type":"section_header","conversion_output":false,"children_ids":["031be6a9dcfa4248a784642c922aedd1"],"text":"","text_display":""},{"cnt":[[192,2298],[436,2298],[436,2341],[192,2341]],"region":{"top_left_x":191,"top_left_y":2298,"width":246,"height":44},"line":34,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"031be6a9dcfa4248a784642c922aedd1","type":"text","conversion_output":true,"parent_id":"b08ab0bdbf0d4f159d5e7e3496dd2aad","text":"Intervention","text_display":"\n\n\\section*{Intervention}","confidence":1,"confidence_rate":1},{"cnt":[[192,2396],[1871,2396],[1871,2442],[192,2442]],"region":{"top_left_x":191,"top_left_y":2396,"width":1680,"height":46},"line":35,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"66c2628e1b7d40f9be75aa400df7cd72","type":"text","conversion_output":true,"text":"After randomization and when the drugs are ready for use, the patient will be equipped with a pulse","text_display":"\n\nAfter randomization and when the drugs are ready for use, the patient will be equipped with a pulse","confidence":1,"confidence_rate":1},{"cnt":[[192,2463],[1839,2463],[1839,2511],[192,2511]],"region":{"top_left_x":191,"top_left_y":2462,"width":1648,"height":49},"line":36,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"10e461e5652249828a0d508ee79c08be","type":"text","conversion_output":true,"text":"oxymetry sensor on his right hand. He/she will be positioned in the incubator and pre-oxygenated","text_display":" oxymetry sensor on his right hand. He/she will be positioned in the incubator and pre-oxygenated","confidence":0.998046875,"confidence_rate":0.9999806434067887},{"cnt":[[192,2527],[1729,2527],[1729,2574],[192,2574]],"region":{"top_left_x":191,"top_left_y":2526,"width":1539,"height":49},"line":37,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"6eddec523f9b48c1870670f053af61ee","type":"text","conversion_output":true,"text":"thanks to an artificial ventilation system connected to a face mask and delivering a positive","text_display":" thanks to an artificial ventilation system connected to a face mask and delivering a positive","confidence":1,"confidence_rate":1},{"cnt":[[192,2595],[1848,2595],[1848,2643],[192,2643]],"region":{"top_left_x":191,"top_left_y":2595,"width":1658,"height":49},"line":38,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"df6a3a56f41e4ab7a174deb18024e817","type":"text","conversion_output":true,"text":"expiratory pressure (PEP): respirator or bag equipped with a PEEP valve, with an \\(FiO _{2}\\) allowing to","text_display":" expiratory pressure (PEP): respirator or bag equipped with a PEEP valve, with an \\(FiO _{2}\\) allowing to","confidence":0.99560546875,"confidence_rate":0.9999617032065153},{"cnt":[[1823,2755],[1878,2755],[1878,2792],[1823,2792]],"region":{"top_left_x":1822,"top_left_y":2754,"width":56,"height":38},"line":39,"column":0,"font_size":23,"is_printed":true,"is_handwritten":false,"id":"a612dcb9a87744d695905f90faf5e1b0","type":"page_info","conversion_output":false,"text":"14","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-15","page":15,"lines":[{"cnt":[[192,148],[1704,148],[1704,196],[192,196]],"region":{"top_left_x":191,"top_left_y":148,"width":1514,"height":49},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"57d2e5e86a3c4877a616c6b8fd891273","type":"text","conversion_output":true,"text":"obtain an \\(SpO _{2} \\geq 95 \\%\\). The intubation will be performed by ajunior or senior doctor with a","text_display":"\nobtain an \\(SpO _{2} \\geq 95 \\%\\). The intubation will be performed by ajunior or senior doctor with a","confidence":0.9956114260718323,"confidence_rate":0.9999585081062292},{"cnt":[[192,215],[1750,215],[1750,263],[192,263]],"region":{"top_left_x":191,"top_left_y":214,"width":1559,"height":49},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"555199bff78e48e6af49f4b4308bca64","type":"text","conversion_output":true,"text":"laryngoscope and an appropriately sized endotracheal tube (ETT)through the orotracheal or","text_display":" laryngoscope and an appropriately sized endotracheal tube (ETT)through the orotracheal or","confidence":1,"confidence_rate":1},{"cnt":[[192,283],[1802,283],[1802,327],[192,327]],"region":{"top_left_x":191,"top_left_y":283,"width":1612,"height":44},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a22a89bf7c8f41f0ac277a06fed0319c","type":"text","conversion_output":true,"text":"nasotracheal route according to usual local practices. The common practice in the departments","text_display":" nasotracheal route according to usual local practices. The common practice in the departments","confidence":1,"confidence_rate":1},{"cnt":[[192,347],[1853,347],[1853,393],[192,393]],"region":{"top_left_x":191,"top_left_y":347,"width":1662,"height":46},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7ba46b62d8804d46a1e2a76d10d0e210","type":"text","conversion_output":true,"text":"participating in the study is to use the nasotracheal route as first-line and to favor junior doctors as","text_display":" participating in the study is to use the nasotracheal route as first-line and to favor junior doctors as","confidence":1,"confidence_rate":1},{"cnt":[[192,416],[1848,416],[1848,459],[192,459]],"region":{"top_left_x":191,"top_left_y":415,"width":1658,"height":45},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ef8f278e92614b5dbdb04ffff58fe2ef","type":"text","conversion_output":true,"text":"the first operator if the condition of the child allows it and under the supervision of a Senior doctor.","text_display":" the first operator if the condition of the child allows it and under the supervision of a Senior doctor.","confidence":1,"confidence_rate":1},{"cnt":[[192,480],[1793,480],[1793,525],[192,525]],"region":{"top_left_x":191,"top_left_y":479,"width":1603,"height":47},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c0fc6af597a141dabc0179555a4f94b7","type":"text","conversion_output":true,"text":"In case of failure, the second operator is usually a senior. There will be no rule imposed on the","text_display":" In case of failure, the second operator is usually a senior. There will be no rule imposed on the","confidence":1,"confidence_rate":1},{"cnt":[[192,544],[1839,544],[1839,592],[192,592]],"region":{"top_left_x":191,"top_left_y":543,"width":1648,"height":49},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"82a9885aede24ad5b6dd5bbd9daad377","type":"text","conversion_output":true,"text":"sequence of the operators because this trial aims to compare the premedications under the usual","text_display":" sequence of the operators because this trial aims to compare the premedications under the usual","confidence":1,"confidence_rate":1},{"cnt":[[192,612],[1853,612],[1853,660],[192,660]],"region":{"top_left_x":191,"top_left_y":612,"width":1662,"height":49},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"27a670fadb374ce58a7365235ac4935c","type":"text","conversion_output":true,"text":"conditions of practice of the neonatal intubations. However, the level of experience of the operator","text_display":" conditions of practice of the neonatal intubations. However, the level of experience of the operator","confidence":1,"confidence_rate":1},{"cnt":[[192,676],[1729,676],[1729,724],[192,724]],"region":{"top_left_x":191,"top_left_y":676,"width":1539,"height":49},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"adebd0e5108d4190b3782a0f73a57f6b","type":"text","conversion_output":true,"text":"\\(( s )\\) will be collected in order to allow a possible adjustment to this criterion if the distribution","text_display":" \\(( s )\\) will be collected in order to allow a possible adjustment to this criterion if the distribution","confidence":0.6301345825195312,"confidence_rate":0.9956526671343188},{"cnt":[[192,745],[729,745],[729,788],[192,788]],"region":{"top_left_x":191,"top_left_y":744,"width":538,"height":45},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1dbb284f365c4fb890a674e7069fbc6e","type":"text","conversion_output":true,"text":"between the groups is different.","text_display":" between the groups is different.","confidence":1,"confidence_rate":1},{"cnt":[[192,1110],[1898,1110],[1898,2680],[192,2680]],"region":{"top_left_x":191,"top_left_y":1110,"width":1708,"height":1570},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"5ed811a13ce84cb08aa41a179904aeeb","type":"table","conversion_output":true,"children_ids":["eec4873856334f32a0feeee6c2c2e8a6","e0831072246c469c85cf818722d5cd22","cdefc75ce20748dfb848f777a48132c0","5c40f9b946314f5eaec8158b64de603e","bdc98c6b9fc945349199188a06b7aa56","6fbaf21c4e36480ba5647eaee0657392","e100be3fbb804f8da745a5e44abfcfdb","f9fe07f7b0b94ca2935c9a02956c96bb","6c8c340f838142d6aa91a4499757d8ed","f9270a62224c487492f2c41a90a4c3bd","6d96ebf43d6644cdab9e6873733cb1fb","f1997ad90e844fc4a49dd444c3ea8ee5","d7b521641bea4a6bb0c8b5fa4c00df46","b7e1ee04a3d44cbea4cf22ab38447f8b","eae9c52e75af471dac02995380a03964","97c5a4c11c424504903cbccf3566ec52","27c60513e894407aacb914dd7f93bfea","5a26c4ba655d44ab8e91b394313d0397","f5576b7d55d54623ab85b5082b6907de","94dfd21988cc4bca84ad6c3210e4391a","d3d5ad60ce7b4790ae111a7dee342950","2cb36a18b47d4ac5834adcc21578b586","90b4d2caf01f449aa087a9c7d2e9b9fa","3ffdaf1bf49b464ab9b7716a4d29a41b","943de049f5784c7b8df1f0ea5eef388b","4cf5a56bf4064b8eb6d423e5fc4729cb","abd72ca445be44b5b9acbb3ae79aa873","a5368f1426d5494f86977c1f83fff545","033454f2d9e94912ad7984dfa93fdeac"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|c|}{weight \\(\\leq 1000 g\\)} \\\\\n\\hline Syringe & SufTrac group & Prop Group \\\\\n\\hline \\(N ^{\\circ} 1\\) & Atropine \\((1 ml =250 \\mu g) 20 \\mu g / kg 0.08 ml / kg\\) IV bolus & Atropine \\((1 ml =250 \\mu g): 20 \\mu g / kg 0,08 ml / kg\\) IV bolus \\\\\n\\hline \\(N ^{\\circ} 2\\) Prepare syringe \\(n^{\\circ} 5\\) simultaneously & Atracurium \\(1 ml =10 mg +9 ml 5 \\% D\\) : \\(0.3 mg / kg\\) -> \\(1 ml =1 mg : 0.3 ml / kg\\) of the dilution IV 30 sec & Normal saline \\(1 ml +9 ml\\) 5\\%D \\(0.3 ml / kg\\) of the dilution IV 30 sec \\\\\n\\hline \\(N ^{\\circ} 3\\) & \\begin{tabular}{l}\nSufentanil \\(1 ml =5 \\mu g+4 ml 5 \\% D : 0.1 \\mu g / kg\\) \\\\\n\\(->1 ml =1 \\mu g: 0,1 ml / kg\\) of the dilution The volume of the syringe will be increased to 1 ml with 5\\%D to allow injection over 60 seconds\n\\end{tabular} & \\begin{tabular}{l}\nNormal saline \\(1 ml +4 ml\\) 5\\%D \\\\\n\\(0.1 ml / kg\\) de la dilution \\\\\nThe volume of the syringe will be increased to 1 ml with 5\\%D to allow injection over 60 seconds\n\\end{tabular} \\\\\n\\hline \\(N ^{\\circ} 4\\) Prepare syringe \\(n^{\\circ} 6\\) simultaneously & Intralipids 20\\%: \\(0.1 ml / kg\\) Increase the volume of the syringe with 5\\%D for injection over 60 seconds, without exceeding 5 times the initial volume of the syringe & Propofol \\(1 \\%: 1 mg / kg 0.1 ml / kg\\) Increase the volume of the syringe with 5\\%D for injection over 60 seconds, without exceeding 5 times the initial volume of the syringe \\\\\n\\hline \\(N ^{\\circ} 5\\) & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 2\\) : 0.1 ml/kg & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 2: 0.1\\) ml/kg \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|c|}{weight \\(\\leq 1000 g\\)} \\\\\n\\hline Syringe & SufTrac group & Prop Group \\\\\n\\hline \\(N ^{\\circ} 1\\) & Atropine \\((1 ml =250 \\mu g) 20 \\mu g / kg 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ml/kg","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.5653600987898244,"confidence_rate":0.9961740281558219},{"cnt":[[546,2482],[939,2482],[939,2526],[546,2526]],"region":{"top_left_x":545,"top_left_y":2482,"width":395,"height":45},"line":81,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1c6bb6c208074b49b786ca71dee3fbc7","type":"text","conversion_output":false,"parent_id":"a5368f1426d5494f86977c1f83fff545","text":"If re-injection required :","text_display":"If re-injection required :","confidence":0.99169921875,"confidence_rate":0.9997311514824022},{"cnt":[[546,2547],[1193,2547],[1193,2593],[546,2593]],"region":{"top_left_x":545,"top_left_y":2546,"width":648,"height":47},"line":82,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8ca2c030cc7a482da75e1cd0b795a96a","type":"text","conversion_output":false,"parent_id":"a5368f1426d5494f86977c1f83fff545","text":"Same dilution as syringe \\(N ^{\\circ} 2\\) : 0.1","text_display":" Same dilution as syringe \\(N ^{\\circ} 2\\) : 0.1","confidence":0.5653600987898244,"confidence_rate":0.9888800843780199},{"cnt":[[546,2611],[640,2611],[640,2660],[546,2660]],"region":{"top_left_x":545,"top_left_y":2611,"width":95,"height":49},"line":83,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"de1e68c3e9a042dd92d1c03759c8fde3","type":"text","conversion_output":false,"parent_id":"a5368f1426d5494f86977c1f83fff545","text":"ml/kg","text_display":" ml/kg","confidence":0.99951171875,"confidence_rate":0.9999511611428449},{"cnt":[[1209,2478],[1888,2478],[1888,2660],[1209,2660]],"region":{"top_left_x":1208,"top_left_y":2477,"width":680,"height":183},"line":84,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"033454f2d9e94912ad7984dfa93fdeac","type":"complex_cell","conversion_output":false,"parent_id":"5ed811a13ce84cb08aa41a179904aeeb","children_ids":["2b181f120625443ab48d97184266dfe0","f0a8bdd330034470bd8bdff3e08fdd7d","b54bcca568d74943b743da9d8c07cc64"],"text":"If re-injection required : Same dilution as syringe \\(N ^{\\circ} 2: 0.1\\) ml/kg","text_display":"If re-injection required : Same dilution as syringe \\(N ^{\\circ} 2: 0.1\\) ml/kg","cell_row":6,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.77197265625,"confidence_rate":0.9961874588847236},{"cnt":[[1213,2482],[1612,2482],[1612,2531],[1213,2531]],"region":{"top_left_x":1213,"top_left_y":2482,"width":399,"height":49},"line":85,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2b181f120625443ab48d97184266dfe0","type":"text","conversion_output":false,"parent_id":"033454f2d9e94912ad7984dfa93fdeac","text":"If re-injection required :","text_display":"If re-injection required :","confidence":0.77197265625,"confidence_rate":0.9916861672104121},{"cnt":[[1213,2547],[1883,2547],[1883,2593],[1213,2593]],"region":{"top_left_x":1213,"top_left_y":2546,"width":671,"height":47},"line":86,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f0a8bdd330034470bd8bdff3e08fdd7d","type":"text","conversion_output":false,"parent_id":"033454f2d9e94912ad7984dfa93fdeac","text":"Same dilution as syringe \\(N ^{\\circ} 2: 0.1\\)","text_display":" Same dilution as syringe \\(N ^{\\circ} 2: 0.1\\)","confidence":0.866666316986084,"confidence_rate":0.9968939371487705},{"cnt":[[1213,2611],[1310,2611],[1310,2660],[1213,2660]],"region":{"top_left_x":1213,"top_left_y":2611,"width":98,"height":49},"line":87,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b54bcca568d74943b743da9d8c07cc64","type":"text","conversion_output":false,"parent_id":"033454f2d9e94912ad7984dfa93fdeac","text":"ml/kg","text_display":" ml/kg","confidence":1,"confidence_rate":1},{"cnt":[[1823,2755],[1873,2755],[1873,2787],[1823,2787]],"region":{"top_left_x":1822,"top_left_y":2754,"width":52,"height":33},"line":88,"column":0,"font_size":23,"is_printed":true,"is_handwritten":false,"id":"bd0d21de4b5f4180b6e2d3951d25c00a","type":"page_info","conversion_output":false,"text":"15","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-16","page":16,"lines":[{"cnt":[[187,142],[1898,142],[1898,354],[187,354]],"region":{"top_left_x":187,"top_left_y":141,"width":1712,"height":214},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b300163391b845fbbe3e4844e6c45ac5","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|}\n\\hline\\(N^{\\circ} 6\\) & \\begin{tabular}{l} \nIf re-injection required : \\\\\nSame dilution as syringe \\(N^{\\circ} 4: 0.1\\) \\\\\n\\(ml / kg\\)\n\\end{tabular} & \\begin{tabular}{l} \nIf re-injection required : \\\\\nSame dilution as syringe \\(N^{\\circ} 4: 0.1\\) \\\\\n\\(ml / kg\\)\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline\\(N^{\\circ} 6\\) & \\begin{tabular}{l} \nIf re-injection required : \\\\\nSame dilution as syringe \\(N^{\\circ} 4: 0.1\\) \\\\\n\\(ml / kg\\)\n\\end{tabular} & \\begin{tabular}{l} \nIf re-injection required : \\\\\nSame dilution as syringe \\(N^{\\circ} 4: 0.1\\) \\\\\n\\(ml / kg\\)\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.2887629267475502,"confidence_rate":0.9946139083724161},{"cnt":[[190,352],[1711,352],[1711,400],[190,400]],"region":{"top_left_x":189,"top_left_y":351,"width":1522,"height":49},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e61bda4754e04f4aaddf13c7cfe6ab45","type":"text","conversion_output":true,"text":"The children will be randomized and 6 syringes will be prepared for each child: 4 syringes","text_display":"\n\nThe children will be randomized and 6 syringes will be prepared for each child: 4 syringes","confidence":1,"confidence_rate":1},{"cnt":[[192,416],[1295,416],[1295,464],[192,464]],"region":{"top_left_x":191,"top_left_y":415,"width":1105,"height":49},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9c1c490a28f74804a68c5a2b6d1b9c79","type":"text","conversion_output":true,"text":"corresponding to the initial injections, 2 syringes for re-injections.","text_display":" corresponding to the initial injections, 2 syringes for re-injections.","confidence":1,"confidence_rate":1},{"cnt":[[192,482],[1684,482],[1684,532],[192,532]],"region":{"top_left_x":191,"top_left_y":482,"width":1493,"height":51},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7beaee2d7dc84653852e4fd094b46100","type":"text","conversion_output":true,"text":"The contents of the syringes are illustrated in the following tables according to weight at","text_display":"\n\nThe contents of the syringes are illustrated in the following tables according to weight at","confidence":1,"confidence_rate":1},{"cnt":[[192,548],[450,548],[450,592],[192,592]],"region":{"top_left_x":191,"top_left_y":548,"width":260,"height":44},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a82c7a520458435a9f328d3485dd7416","type":"text","conversion_output":true,"text":"randomization:","text_display":" randomization:","confidence":1,"confidence_rate":1},{"cnt":[[1823,2755],[1875,2755],[1875,2792],[1823,2792]],"region":{"top_left_x":1822,"top_left_y":2754,"width":54,"height":38},"line":6,"column":0,"font_size":23,"is_printed":true,"is_handwritten":false,"id":"bbe1471eb05346329af6ec22e1b1c597","type":"page_info","conversion_output":false,"text":"16","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-17","page":17,"lines":[{"cnt":[[128,57],[1837,57],[1837,1768],[128,1768]],"region":{"top_left_x":127,"top_left_y":57,"width":1710,"height":1712},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2b730a00ab09419d962ef4454abc311b","type":"table","conversion_output":true,"children_ids":["20e980f55ebb46ac81b9db9830428b23","170e215ff0854ce3a1d920ebd7e2d797","0257d4c245a647e79e1d5a06ca3c108f","b46c55053add4722bcd589b1c3580c1e","473a02dbd8fe4e4d9adec30e100c52b0","d9f6afaf3b2b4f8b985a7ba928e938b7","7fc7114bc94b4801ab0c21825ddfbf4f","c3b3037046ce40658c627e30d0dfa10e","e2af2be5e08b4044a5ea10c0d8b27683","2be609a197fa40d8984374d43c34b4e5","99b35d70ef074716a85fb337b7d0afa2","1a06096621cc47c4b73f1dd92d4b4d24","470206a79497427fb8a47e8db7cf4cb2","8b54dec1b74748548e5ffdcc3e9ab546","cebc50ae56554254a8c92eaa6716e529","c955cfbfdc054a6daeaa89d20aed787c","c74fc14b2f5f48dd95d52582df88a18f","3bcb0ab264134326ad033663ed419b44","f666f4300648439d81cf041e200602e2","77eb0fc90aab48bab64db4160951509f","002311b94dc6419a8f4654f8f77720b1","7b9071b32c16493fab32901c425b0c5b","17967d759eac4f6a8286476a8b0c9574","18fd7499e9a04ad2a450f66c29dafc86","0dbd8537c4794c49875e5f301c55c9d7","b366a11eecb94662ad9ee9db58bc3c2a","052ae99885e94c078b367689ff80fb32","10a027ac9cf4452386ab1f1bfa0b739d","7245bec567554ff3b935a28f4cabe258","d18f03e5e68043a4b893476b01c5f5a7","96525a1858fe4aa6be6bc033bd9ec82a"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Syringe & SufTrac group & Prop Group \\\\\n\\hline \\(N ^{\\circ} 1\\) & Atropine \\((1 ml =250 \\mu g) 20 \\mu g / kg 0.08 ml / kg\\) IV bolus & Atropine \\((1 ml =250 \\mu g): 20 \\mu g / kg 0,08 ml / kg\\) IV bolus \\\\\n\\hline \\(N ^{\\circ} 2\\) Prepare syringe \\(n^{\\circ} 5\\) simultaneously & Atracurium \\(1 ml =10 mg +9 ml 5 \\% D\\) : \\(0.3 mg / kg\\) - \\(>1 ml =1 mg : 0.3 ml / kg\\) of the dilution IV 30 sec & Normal saline \\(1 ml +9 ml\\) 5\\%D \\(0.3 ml / kg\\) of the dilution IV 30 sec \\\\\n\\hline \\(N ^{\\circ} 3\\) & \\begin{tabular}{l}\nSufentanil \\(1 ml =5 \\mu g+4 ml 5 \\% D 0.2 \\mu g / kg\\) \\\\\n\\(->1 ml =1 \\mu g: 0.2 ml / kg\\) of the dilution The volume of the syringe will be increased to 1 ml with 5\\%D to allow injection over 60 seconds\n\\end{tabular} & \\begin{tabular}{l}\nNormal saline \\(1 ml +4 ml\\) 5\\%D \\(0.2 ml / kg\\) of the dilution \\\\\nThe volume of the syringe will be increased to 1 ml with 5\\%D to allow injection over 60 seconds\n\\end{tabular} \\\\\n\\hline \\(N ^{\\circ} 4\\) Prepare syringe \\(n^{\\circ} 6\\) simultaneously & Intralipids 20\\%: \\(0.25 ml / kg\\) Increase the volume of the syringe with 5\\%D for injection over 60 seconds, without exceeding 5 times the initial volume of the syringe & Propofol 1\\%: \\(2.5 mg / kg 0.25 ml / kg\\) Increase the volume of the syringe with \\(5 \\%\\) D for injection over 60 seconds, without exceeding 5 times the initial volume of the syringe \\\\\n\\hline \\(N ^{\\circ} 5\\) & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 2\\) : 0.1 ml/kg & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 2\\) : 0.1 ml/kg \\\\\n\\hline \\(N ^{\\circ} 6\\) & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 4\\) : 0.1 ml/kg & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 4\\) : 0.1 ml/kg \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Syringe & SufTrac group & Prop Group \\\\\n\\hline \\(N ^{\\circ} 1\\) & Atropine \\((1 ml =250 \\mu g) 20 \\mu g / kg 0.08 ml / kg\\) IV bolus & Atropine \\((1 ml =250 \\mu g): 20 \\mu g / kg 0,08 ml / kg\\) IV bolus \\\\\n\\hline \\(N ^{\\circ} 2\\) Prepare syringe \\(n^{\\circ} 5\\) simultaneously & Atracurium \\(1 ml =10 mg +9 ml 5 \\% D\\) : \\(0.3 mg / kg\\) - \\(>1 ml =1 mg : 0.3 ml / kg\\) of the dilution IV 30 sec & Normal saline \\(1 ml +9 ml\\) 5\\%D \\(0.3 ml / kg\\) of the dilution IV 30 sec \\\\\n\\hline \\(N ^{\\circ} 3\\) & \\begin{tabular}{l}\nSufentanil \\(1 ml =5 \\mu g+4 ml 5 \\% D 0.2 \\mu g / kg\\) \\\\\n\\(->1 ml =1 \\mu g: 0.2 ml / kg\\) of the dilution The volume of the syringe will be increased to 1 ml with 5\\%D to allow injection over 60 seconds\n\\end{tabular} & \\begin{tabular}{l}\nNormal saline \\(1 ml +4 ml\\) 5\\%D \\(0.2 ml / kg\\) of the dilution \\\\\nThe volume of the syringe will be increased to 1 ml with 5\\%D to allow injection over 60 seconds\n\\end{tabular} \\\\\n\\hline \\(N ^{\\circ} 4\\) Prepare syringe \\(n^{\\circ} 6\\) simultaneously & Intralipids 20\\%: \\(0.25 ml / kg\\) Increase the volume of the syringe with 5\\%D for injection over 60 seconds, without exceeding 5 times the initial volume of the syringe & Propofol 1\\%: \\(2.5 mg / kg 0.25 ml / kg\\) Increase the volume of the syringe with \\(5 \\%\\) D for injection over 60 seconds, without exceeding 5 times the initial volume of the syringe \\\\\n\\hline \\(N ^{\\circ} 5\\) & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 2\\) : 0.1 ml/kg & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 2\\) : 0.1 ml/kg \\\\\n\\hline \\(N ^{\\circ} 6\\) & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 4\\) : 0.1 ml/kg & If re-injection required : Same dilution as syringe \\(N ^{\\circ} 4\\) : 0.1 ml/kg \\\\\n\\hline\n\\end{tabular}","confidence":0.5165470463816746,"confidence_rate":0.9980630579199763},{"cnt":[[136,57],[468,57],[468,1770],[136,1770]],"region":{"top_left_x":136,"top_left_y":57,"width":332,"height":1714},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"20e980f55ebb46ac81b9db9830428b23","type":"table_column","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[470,57],[1145,57],[1145,1768],[470,1768]],"region":{"top_left_x":470,"top_left_y":57,"width":675,"height":1711},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"170e215ff0854ce3a1d920ebd7e2d797","type":"table_column","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[1142,57],[1833,57],[1833,1770],[1142,1770]],"region":{"top_left_x":1142,"top_left_y":57,"width":692,"height":1714},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0257d4c245a647e79e1d5a06ca3c108f","type":"table_column","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[127,103],[1838,103],[1838,156],[127,156]],"region":{"top_left_x":127,"top_left_y":103,"width":1711,"height":54},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b46c55053add4722bcd589b1c3580c1e","type":"table_row","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[127,170],[1838,170],[1838,292],[127,292]],"region":{"top_left_x":127,"top_left_y":169,"width":1711,"height":123},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"473a02dbd8fe4e4d9adec30e100c52b0","type":"table_row","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[127,301],[1838,301],[1838,561],[127,561]],"region":{"top_left_x":127,"top_left_y":301,"width":1711,"height":261},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d9f6afaf3b2b4f8b985a7ba928e938b7","type":"table_row","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[127,566],[1838,566],[1838,955],[127,955]],"region":{"top_left_x":127,"top_left_y":565,"width":1711,"height":390},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7fc7114bc94b4801ab0c21825ddfbf4f","type":"table_row","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[127,964],[1838,964],[1838,1353],[127,1353]],"region":{"top_left_x":127,"top_left_y":964,"width":1711,"height":390},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c3b3037046ce40658c627e30d0dfa10e","type":"table_row","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[127,1360],[1838,1360],[1838,1556],[127,1556]],"region":{"top_left_x":127,"top_left_y":1360,"width":1711,"height":196},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e2af2be5e08b4044a5ea10c0d8b27683","type":"table_row","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[127,1561],[1838,1561],[1838,1759],[127,1759]],"region":{"top_left_x":127,"top_left_y":1560,"width":1711,"height":199},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2be609a197fa40d8984374d43c34b4e5","type":"table_row","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"","text_display":""},{"cnt":[[228,108],[378,108],[378,154],[228,154]],"region":{"top_left_x":228,"top_left_y":107,"width":150,"height":47},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"99b35d70ef074716a85fb337b7d0afa2","type":"simple_cell","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"Syringe","text_display":"Syringe","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[670,108],[940,108],[940,151],[670,151]],"region":{"top_left_x":670,"top_left_y":107,"width":270,"height":45},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1a06096621cc47c4b73f1dd92d4b4d24","type":"simple_cell","conversion_output":false,"parent_id":"2b730a00ab09419d962ef4454abc311b","text":"SufTrac 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This product will be deconditioned in","text_display":" (Frésenius Kasbi) used for parenteral nutrition in newborns. This product will be deconditioned in","confidence":1,"confidence_rate":1},{"cnt":[[192,484],[1821,484],[1821,528],[192,528]],"region":{"top_left_x":191,"top_left_y":484,"width":1630,"height":44},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c0c37723c0cc44779c51daf8db5302da","type":"text","conversion_output":true,"text":"sterile conditions by Baccinex and reconditioned in sterile conditions in 50 ml vials. Baccinex will","text_display":" sterile conditions by Baccinex and reconditioned in sterile conditions in 50 ml vials. 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The \"heads\" of sufentanil and","text_display":" constituting respectively the placebo for sufentanil and atracurium. 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For long-term follow-up, data collection is planned up to two-years corrected","text_display":" first drug injection. 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Protocol.","confidence":1,"confidence_rate":1},{"cnt":[[187,1115],[1732,1115],[1732,1172],[187,1172]],"region":{"top_left_x":187,"top_left_y":1114,"width":1545,"height":58},"line":14,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"168eddc23b954701a947b70e94e97a5e","type":"section_header","conversion_output":false,"children_ids":["f1e11d22520148498147c7a8830b3e4d"],"text":"","text_display":""},{"cnt":[[192,1119],[1727,1119],[1727,1167],[192,1167]],"region":{"top_left_x":191,"top_left_y":1119,"width":1536,"height":49},"line":15,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"f1e11d22520148498147c7a8830b3e4d","type":"text","conversion_output":true,"parent_id":"168eddc23b954701a947b70e94e97a5e","text":"Medicinal products and treatments authorized and prohibited under the Protocol","text_display":"\n\n\\section*{Medicinal products and treatments authorized and prohibited under the Protocol}","confidence":1,"confidence_rate":1},{"cnt":[[192,1220],[1869,1220],[1869,1268],[192,1268]],"region":{"top_left_x":191,"top_left_y":1219,"width":1678,"height":49},"line":16,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9b3bf457886a47c5af69bce6a0840732","type":"text","conversion_output":true,"text":"Administration of a sedative or anesthetic treatment within 24 hours prior to intubation constitutes a","text_display":"\n\nAdministration of a sedative or anesthetic treatment within 24 hours prior to intubation constitutes a","confidence":1,"confidence_rate":1},{"cnt":[[192,1288],[765,1288],[765,1336],[192,1336]],"region":{"top_left_x":191,"top_left_y":1288,"width":575,"height":49},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ecb7352c959144e89dfae3e09863ace2","type":"text","conversion_output":true,"text":"non-inclusion criteria in the study.","text_display":" non-inclusion criteria in the study.","confidence":1,"confidence_rate":1},{"cnt":[[192,1352],[1873,1352],[1873,1398],[192,1398]],"region":{"top_left_x":191,"top_left_y":1352,"width":1683,"height":47},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"4211ffb081e842219a9610b91497abe6","type":"text","conversion_output":true,"text":"The administration of a morphine agonist-antagonist treatment is contraindicated within 24 hours of","text_display":"\n\nThe administration of a morphine agonist-antagonist treatment is contraindicated within 24 hours of","confidence":1,"confidence_rate":1},{"cnt":[[192,1416],[359,1416],[359,1460],[192,1460]],"region":{"top_left_x":191,"top_left_y":1416,"width":168,"height":44},"line":19,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"df93af94cedb421cbcde40cd471cf715","type":"text","conversion_output":true,"text":"inclusion.","text_display":" 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In the absence of extreme agitation","text_display":"\n\nAny treatment deemed necessary for the patient is permitted. In the absence of extreme agitation","confidence":1,"confidence_rate":1},{"cnt":[[192,1549],[1816,1549],[1816,1597],[192,1597]],"region":{"top_left_x":191,"top_left_y":1548,"width":1626,"height":49},"line":21,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"760181946a5a4b85a02ef1d22fab6414","type":"text","conversion_output":true,"text":"or obvious pain, no sedative or anesthetic treatment should be administered within 1 hour of the","text_display":" or obvious pain, no sedative or anesthetic treatment should be administered within 1 hour of the","confidence":1,"confidence_rate":1},{"cnt":[[192,1617],[473,1617],[473,1665],[192,1665]],"region":{"top_left_x":191,"top_left_y":1617,"width":282,"height":49},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"bd0d5c9bdc79440d86c147d078e0e349","type":"text","conversion_output":true,"text":"study treatment.","text_display":" study 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be recorded during the study by direct observation.","confidence":1,"confidence_rate":1},{"cnt":[[192,2083],[1647,2083],[1647,2131],[192,2131]],"region":{"top_left_x":191,"top_left_y":2083,"width":1457,"height":49},"line":29,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d9abb3d0f5cd445b8f7f396803def04a","type":"text","conversion_output":true,"text":"Given the uniqueness of the administration, no compliance problems are to be feared.","text_display":"\nGiven the uniqueness of the administration, no compliance problems are to be feared.","confidence":1,"confidence_rate":1},{"cnt":[[192,2150],[1839,2150],[1839,2195],[192,2195]],"region":{"top_left_x":191,"top_left_y":2149,"width":1648,"height":47},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0179024dc07b4ca295400c68733445b7","type":"text","conversion_output":true,"text":"The remaining quantities of unused product will be disposed of and empty vials will be sent to the","text_display":"\nThe remaining quantities of unused product will be disposed of and empty vials will be sent to the","confidence":1,"confidence_rate":1},{"cnt":[[192,2216],[1343,2216],[1343,2264],[192,2264]],"region":{"top_left_x":191,"top_left_y":2215,"width":1153,"height":49},"line":31,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1e4e88c1bf0c4ca498060f543ab1d634","type":"text","conversion_output":true,"text":"local pharmacies at each center for posting and tracking of batches.","text_display":" local pharmacies at each center for posting and tracking of batches.","confidence":1,"confidence_rate":1},{"cnt":[[187,2316],[978,2316],[978,2373],[187,2373]],"region":{"top_left_x":187,"top_left_y":2316,"width":791,"height":58},"line":32,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"7ff9633b555c427cb3b17a7833bd7b08","type":"section_header","conversion_output":false,"children_ids":["472b21fbc9da48bb9e98704930864fea"],"text":"","text_display":""},{"cnt":[[192,2319],[971,2319],[971,2369],[192,2369]],"region":{"top_left_x":191,"top_left_y":2318,"width":780,"height":51},"line":33,"column":0,"font_size":37,"is_printed":true,"is_handwritten":false,"id":"472b21fbc9da48bb9e98704930864fea","type":"text","conversion_output":true,"parent_id":"7ff9633b555c427cb3b17a7833bd7b08","text":"Storage conditions of experimental drugs","text_display":"\n\n\\section*{Storage conditions of experimental 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It can also be stored at \\(+4^{\\circ} C\\), at","text_display":"\n\nPropofol can be stored at a temperature not exceeding \\(25^{\\circ} C\\). It can also be stored at \\(+4^{\\circ} C\\), at","confidence":0.8744444309268147,"confidence_rate":0.9989357529799182},{"cnt":[[192,2485],[1839,2485],[1839,2533],[192,2533]],"region":{"top_left_x":191,"top_left_y":2485,"width":1648,"height":49},"line":35,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"d2c51daf7cb04f0fa6258b56f6a615da","type":"text","conversion_output":true,"text":"which temperature its stability is 36 months. It must be used within 6 hours of its preparation. The","text_display":" which temperature its stability is 36 months. It must be used within 6 hours of its preparation. The","confidence":0.9990236759185791,"confidence_rate":0.9999912000297451},{"cnt":[[192,2549],[829,2549],[829,2597],[192,2597]],"region":{"top_left_x":191,"top_left_y":2549,"width":639,"height":49},"line":36,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a62c427ff39d4e86a991a2919088f285","type":"text","conversion_output":true,"text":"unused quantity should be discarded.","text_display":" unused quantity should be discarded.","confidence":1,"confidence_rate":1},{"cnt":[[190,2616],[1866,2616],[1866,2664],[190,2664]],"region":{"top_left_x":189,"top_left_y":2615,"width":1678,"height":49},"line":37,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"4390c515f97b4bd0a20d7544247126e5","type":"text","conversion_output":true,"text":"Atropine can be stored at room temperature or between \\(+4^{\\circ} C\\) and \\(+8^{\\circ} C\\) (lab advice Aguettant).","text_display":"\n\nAtropine can be stored at room temperature or between \\(+4^{\\circ} C\\) and \\(+8^{\\circ} C\\) (lab advice Aguettant).","confidence":0.9990236759185791,"confidence_rate":0.9999919934665097},{"cnt":[[1823,2755],[1878,2755],[1878,2794],[1823,2794]],"region":{"top_left_x":1822,"top_left_y":2754,"width":56,"height":40},"line":38,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b90183151b8e47d7b55dca3a38e0a8b9","type":"page_info","conversion_output":false,"text":"つマ","text_display":"","confidence":0.75921630859375,"confidence_rate":0.961411607467962}],"page_height":2924,"page_width":2066,"languages_detected":[]},{"image_id":"8dcc45e4-876c-4c3a-b86c-8f113a99c45c-24","page":24,"lines":[{"cnt":[[192,148],[1853,148],[1853,196],[192,196]],"region":{"top_left_x":191,"top_left_y":148,"width":1662,"height":49},"line":1,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1fcf3f5fcb3e47c9baca7b2c8f47f59e","type":"text","conversion_output":true,"text":"Sufentanil may be stored at room temperature at a temperature not exceeding \\(25^{\\circ} C\\). It should be","text_display":"\n\nSufentanil may be stored at room temperature at a temperature not exceeding \\(25^{\\circ} C\\). It should be","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[192,215],[1574,215],[1574,263],[192,263]],"region":{"top_left_x":191,"top_left_y":214,"width":1383,"height":49},"line":2,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"cbc19122473b4ba19bbf9c2371782f69","type":"text","conversion_output":true,"text":"used within 24 hours of its preparation. The unused quantity should be discarded.","text_display":" used within 24 hours of its preparation. The unused quantity should be discarded.","confidence":1,"confidence_rate":1},{"cnt":[[187,279],[1807,279],[1807,331],[187,331]],"region":{"top_left_x":187,"top_left_y":278,"width":1620,"height":54},"line":3,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7fa5de6071fb496da92fd3e84bd127ab","type":"text","conversion_output":true,"text":"Atracurium should be stored in the refrigerator (between \\(+2^{\\circ} C\\) and \\(+8^{\\circ} C\\) ) and should not be","text_display":"\n\nAtracurium should be stored in the refrigerator (between \\(+2^{\\circ} C\\) and \\(+8^{\\circ} C\\) ) and should not be","confidence":0.9775390625,"confidence_rate":0.9998122736039274},{"cnt":[[187,343],[1725,343],[1725,395],[187,395]],"region":{"top_left_x":187,"top_left_y":342,"width":1538,"height":54},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0ba520cd4e314f049b0dde6bb08f310a","type":"text","conversion_output":true,"text":"frozen. 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The unused quantity should be discarded.","confidence":1,"confidence_rate":1},{"cnt":[[192,477],[1807,477],[1807,528],[192,528]],"region":{"top_left_x":191,"top_left_y":477,"width":1616,"height":51},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b3643e30e8e04820acbd00244fb2649b","type":"text","conversion_output":true,"text":"Lavoisier sodium chloride 0.9 per cent solution for injection, packaged in glass vials requires no","text_display":" Lavoisier sodium chloride 0.9 per cent solution for injection, packaged in glass vials requires no","confidence":1,"confidence_rate":1},{"cnt":[[192,544],[674,544],[674,592],[192,592]],"region":{"top_left_x":191,"top_left_y":543,"width":483,"height":49},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8acce8950df64704b63cdb6c9e99cf72","type":"text","conversion_output":true,"text":"special storage precautions.","text_display":" special storage precautions.","confidence":1,"confidence_rate":1},{"cnt":[[190,608],[1419,608],[1419,660],[190,660]],"region":{"top_left_x":189,"top_left_y":607,"width":1230,"height":54},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"66d60329836b4619a65b7ef7e8da4749","type":"text","conversion_output":true,"text":"Intralipids 20\\% Fresenius must be stored at a temperature below \\(25^{\\circ} C\\).","text_display":"\n\nIntralipids 20\\% Fresenius must be stored at a temperature below \\(25^{\\circ} C\\).","confidence":1,"confidence_rate":1},{"cnt":[[187,672],[1866,672],[1866,724],[187,724]],"region":{"top_left_x":187,"top_left_y":671,"width":1680,"height":54},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8dad688a44c4408694b2e185617d3be2","type":"text","conversion_output":true,"text":"The study kits will therefore be stored between \\(+2^{\\circ} C\\) and \\(+8^{\\circ} C\\) in a locked refrigerator provided","text_display":"\nThe study kits will therefore be stored between \\(+2^{\\circ} C\\) and \\(+8^{\\circ} C\\) in a locked refrigerator provided","confidence":0.5330657958984375,"confidence_rate":0.9950195041795331},{"cnt":[[190,740],[1862,740],[1862,790],[190,790]],"region":{"top_left_x":189,"top_left_y":740,"width":1673,"height":51},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"df0cb9b79c5a49a091ba578e9b8cf871","type":"text","conversion_output":true,"text":"to the centers by the sponsor for study purposes. The key of this refrigerator will be kept and made","text_display":" to the centers by the sponsor for study purposes. The key of this refrigerator will be kept and made","confidence":1,"confidence_rate":1},{"cnt":[[190,806],[1825,806],[1825,857],[190,857]],"region":{"top_left_x":189,"top_left_y":806,"width":1637,"height":51},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c887b0a9589149e08331356fc33436c1","type":"text","conversion_output":true,"text":"available in each pharmacy for internal use according to the same modalities as the key allowing","text_display":" available in each pharmacy for internal use according to the same modalities as the key allowing","confidence":0.99853515625,"confidence_rate":0.9999854860688677},{"cnt":[[187,873],[596,873],[596,921],[187,921]],"region":{"top_left_x":187,"top_left_y":872,"width":410,"height":49},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1ecc9735514243078e9017eeac060951","type":"text","conversion_output":true,"text":"the access to narcotics.","text_display":" the access to narcotics.","confidence":1,"confidence_rate":1},{"cnt":[[187,937],[1816,937],[1816,989],[187,989]],"region":{"top_left_x":187,"top_left_y":936,"width":1630,"height":54},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1e147586a6644a65a079e9ca9270898e","type":"text","conversion_output":true,"text":"Within Theradis Pharma, under the procedure \"Management of narcotic drugs and psychotropic","text_display":"\n\nWithin Theradis Pharma, under the procedure \"Management of narcotic drugs and psychotropic","confidence":1,"confidence_rate":1},{"cnt":[[190,1005],[318,1005],[318,1053],[190,1053]],"region":{"top_left_x":189,"top_left_y":1005,"width":129,"height":49},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"f076504e2e7542f882c8a313a31d6fff","type":"text","conversion_output":true,"text":"drugs\":","text_display":" drugs\":","confidence":1,"confidence_rate":1},{"cnt":[[187,1067],[1738,1067],[1738,1122],[187,1122]],"region":{"top_left_x":187,"top_left_y":1066,"width":1552,"height":56},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"70e0b1a26425454fab7c241bfef1fd9d","type":"text","conversion_output":true,"text":"The narcotics are stored in a locked area, access to which is protected by a grid. This room","text_display":"\nThe narcotics are stored in a locked area, access to which is protected by a grid. This room","confidence":1,"confidence_rate":1},{"cnt":[[187,1133],[1761,1133],[1761,1186],[187,1186]],"region":{"top_left_x":187,"top_left_y":1133,"width":1575,"height":53},"line":16,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"daf8f2d58b2a44449b5136b67205cc95","type":"text","conversion_output":true,"text":"contains nothing but narcotics. It is also equipped with a refrigerator and a freezer for special","text_display":" contains nothing but narcotics. 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The randomization is stratified on the weight of the child at the time of","text_display":" analysis (all other variables). The randomization is stratified on the weight of the child at the time of","confidence":1,"confidence_rate":1},{"cnt":[[192,1019],[1866,1019],[1866,1067],[192,1067]],"region":{"top_left_x":191,"top_left_y":1018,"width":1676,"height":49},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"48bf71abb965413c8b1c57484052a2d8","type":"text","conversion_output":true,"text":"intubation and on center, the two groups will be not be compared for these characteristics because","text_display":" intubation and on center, the two groups will be not be compared for these characteristics because","confidence":0.998046875,"confidence_rate":0.9999810192594005},{"cnt":[[192,1087],[699,1087],[699,1135],[192,1135]],"region":{"top_left_x":191,"top_left_y":1087,"width":509,"height":49},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"5b9e8644941e424ea27f05a7e0cca086","type":"text","conversion_output":true,"text":"of the randomization 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intubation","confidence":1,"confidence_rate":1},{"cnt":[[192,1348],[1752,1348],[1752,1396],[192,1396]],"region":{"top_left_x":191,"top_left_y":1347,"width":1562,"height":49},"line":17,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c262cee6d66e4668baf2ac28a6dad042","type":"text","conversion_output":true,"text":"and number of intubation attempts) and analysis of variance (for total duration of intubation).","text_display":" and number of intubation attempts) and analysis of variance (for total duration of intubation).","confidence":1,"confidence_rate":1},{"cnt":[[190,1416],[1821,1416],[1821,1464],[190,1464]],"region":{"top_left_x":189,"top_left_y":1416,"width":1632,"height":49},"line":18,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"629fb07976bf4ac2aa0cc814a7f94783","type":"text","conversion_output":true,"text":"A subgroup analysis according to weight categories will be performed if the interaction test (chi2","text_display":" A 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worsening of head","confidence":1,"confidence_rate":1},{"cnt":[[192,2275],[1706,2275],[1706,2323],[192,2323]],"region":{"top_left_x":191,"top_left_y":2275,"width":1516,"height":49},"line":30,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"65ec0ab26c8d466fa78ee09fc3470a03","type":"text","conversion_output":true,"text":"ultrasound, the analysis will be conducted according to the intent to treat principle using a","text_display":" ultrasound, the analysis will be conducted according to the intent to treat principle using a","confidence":1,"confidence_rate":1},{"cnt":[[192,2339],[1839,2339],[1839,2387],[192,2387]],"region":{"top_left_x":191,"top_left_y":2339,"width":1648,"height":49},"line":31,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"37b93e65b6cc4503a775742fcc9f9f82","type":"text","conversion_output":true,"text":"generalized mixed model with a log-binomial distribution adjusted on weight at inclusion \\((\\leq 1000 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Generalized linear mixed models are an","text_display":" (exchangeable within-center correlation structure). 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For the primary outcome, which","text_display":"\nspecify the distribution of the variable to explain (ie, the outcome). 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No other funding was requested for this study. The application for","text_display":" supplement in September 2014. No other funding was requested for this study. The application for","confidence":1,"confidence_rate":1},{"cnt":[[190,484],[1802,484],[1802,535],[190,535]],"region":{"top_left_x":189,"top_left_y":484,"width":1614,"height":51},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0e35d275b90745958b523df9c909c9f9","type":"text","conversion_output":true,"text":"funding included in this study takes into account the cost of medical and paramedical time in all","text_display":" funding included in this study takes into account the cost of medical and paramedical time in all","confidence":1,"confidence_rate":1},{"cnt":[[192,548],[1704,548],[1704,601],[192,601]],"region":{"top_left_x":191,"top_left_y":548,"width":1514,"height":53},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"150ab7650fb3477398fa5655f7e849de","type":"text","conversion_output":true,"text":"centers (two full-time equivalents for the entire study), the cost of the CRA and its regular","text_display":" centers (two full-time equivalents for the entire study), the cost of the CRA and its regular","confidence":1,"confidence_rate":1},{"cnt":[[192,617],[1793,617],[1793,665],[192,665]],"region":{"top_left_x":191,"top_left_y":616,"width":1603,"height":49},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9d5fac129e964337bb593e609a72f37c","type":"text","conversion_output":true,"text":"movements. 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CRC monitors from CHI Créteil will monitor the study.","text_display":"\nThe CRA of each site will ensure data entry. CRC monitors from CHI Créteil will monitor the study.","confidence":1,"confidence_rate":1},{"cnt":[[192,1010],[1866,1010],[1866,1062],[192,1062]],"region":{"top_left_x":191,"top_left_y":1009,"width":1676,"height":54},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"b9f25bc432714819b73526071962ef69","type":"text","conversion_output":true,"text":"Insurance has been taken out in accordance with the provisions of article L.1121-10 of the Code of","text_display":" Insurance has been taken out in accordance with the provisions of article L.1121-10 of the Code of","confidence":0.98095703125,"confidence_rate":0.9998133511944108},{"cnt":[[192,1074],[1122,1074],[1122,1126],[192,1126]],"region":{"top_left_x":191,"top_left_y":1073,"width":931,"height":54},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7e5fa8d92a9945b786a528d4873b0044","type":"text","conversion_output":true,"text":"Public Health. 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A representative of ACTIV will also be","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[192,1544],[528,1544],[528,1594],[192,1594]],"region":{"top_left_x":191,"top_left_y":1544,"width":337,"height":51},"line":22,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9505a43c908c409caebaa3f01ad0f66e","type":"text","conversion_output":true,"text":"among the authors.","text_display":" among the authors.","confidence":1,"confidence_rate":1},{"cnt":[[187,1645],[633,1645],[633,1706],[187,1706]],"region":{"top_left_x":187,"top_left_y":1644,"width":446,"height":63},"line":23,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"8ab3e7a28c3f498ca048eeeec6eca043","type":"section_header","conversion_output":false,"children_ids":["9bc8bf58e02b4effb67b89a3caf5cc79"],"text":"","text_display":""},{"cnt":[[192,1649],[626,1649],[626,1702],[192,1702]],"region":{"top_left_x":191,"top_left_y":1649,"width":435,"height":53},"line":24,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"9bc8bf58e02b4effb67b89a3caf5cc79","type":"text","conversion_output":true,"parent_id":"8ab3e7a28c3f498ca048eeeec6eca043","text":"Feasibility of the study","text_display":"\n\n\\section*{Feasibility of the study}","confidence":1,"confidence_rate":1},{"cnt":[[192,1750],[1711,1750],[1711,1798],[192,1798]],"region":{"top_left_x":191,"top_left_y":1749,"width":1520,"height":49},"line":25,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"603c1ac114fe4ce89ac3c2292810b9d7","type":"text","conversion_output":true,"text":"Each participating center has a high annual recruitment. They all have solid experience in","text_display":"\n\nEach participating center has a high annual recruitment. They all have solid experience in","confidence":1,"confidence_rate":1},{"cnt":[[192,1814],[1711,1814],[1711,1866],[192,1866]],"region":{"top_left_x":191,"top_left_y":1813,"width":1520,"height":54},"line":26,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2acfd2c673634e2492af2fbc796a753c","type":"text","conversion_output":true,"text":"multicenter clinical trials. In the prospective study carried out in Creteil's NICU in 2007, 35","text_display":" multicenter clinical trials. 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It can therefore be estimated that in each center - the number of annual","text_display":" intubations per year. 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This rate appears to be","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[192,2211],[1843,2211],[1843,2259],[192,2259]],"region":{"top_left_x":191,"top_left_y":2211,"width":1653,"height":49},"line":32,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"2dfcd9bedb36469597649bee27b6a415","type":"text","conversion_output":true,"text":"reasonably achievable given the experience of each of the participating centers. In each center, a","text_display":" reasonably achievable given the experience of each of the participating centers. 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These research technicians will also be","text_display":" information to parents of potentially eligible children. 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Vanlersberghe C, Camu F. Propofol. Handb Exp Pharmacol. 2008(182):227-252.","text_display":"\n1. Vanlersberghe C, Camu F. Propofol. Handb Exp Pharmacol. 2008(182):227-252.","confidence":1,"confidence_rate":1},{"cnt":[[187,468],[1798,468],[1798,519],[187,519]],"region":{"top_left_x":187,"top_left_y":468,"width":1611,"height":51},"line":4,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0af386ddc81d4b1c85ba06e05da830de","type":"text","conversion_output":true,"text":"2. Bhutta AT, Anand KJ. Vulnerability of the developing brain. Neuronal mechanisms. Clin","text_display":"\n2. Bhutta AT, Anand KJ. Vulnerability of the developing brain. Neuronal mechanisms. Clin","confidence":1,"confidence_rate":1},{"cnt":[[315,535],[843,535],[843,583],[315,583]],"region":{"top_left_x":315,"top_left_y":534,"width":528,"height":49},"line":5,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a911614d453e40f888a35b7019281e88","type":"text","conversion_output":true,"text":"Perinatol. 2002;29(3):357-372.","text_display":" Perinatol. 2002;29(3):357-372.","confidence":1,"confidence_rate":1},{"cnt":[[190,599],[1780,599],[1780,651],[190,651]],"region":{"top_left_x":189,"top_left_y":598,"width":1591,"height":54},"line":6,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"e46e42587dfe4cd78edbf5b129aef74f","type":"text","conversion_output":true,"text":"3. Prevention and management of pain and stress in the neonate. American Academy of","text_display":"\n3. Prevention and management of pain and stress in the neonate. American Academy of","confidence":1,"confidence_rate":1},{"cnt":[[315,667],[1670,667],[1670,715],[315,715]],"region":{"top_left_x":315,"top_left_y":667,"width":1355,"height":49},"line":7,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"0a4ea027aaaf4cefb38ee40a9878abf6","type":"text","conversion_output":true,"text":"Pediatrics. Committee on Fetus and Newborn. Committee on Drugs. Section on","text_display":" Pediatrics. Committee on Fetus and Newborn. Committee on Drugs. Section on","confidence":1,"confidence_rate":1},{"cnt":[[315,731],[1786,731],[1786,781],[315,781]],"region":{"top_left_x":315,"top_left_y":730,"width":1472,"height":52},"line":8,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"1f10e3a728c74f29886c1c71e7a7fe1b","type":"text","conversion_output":true,"text":"Anesthesiology. Section on Surgery. Canadian Paediatric Society. Fetus and Newborn","text_display":" Anesthesiology. Section on Surgery. Canadian Paediatric Society. Fetus and Newborn","confidence":1,"confidence_rate":1},{"cnt":[[315,800],[1087,800],[1087,848],[315,848]],"region":{"top_left_x":315,"top_left_y":799,"width":773,"height":49},"line":9,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"a14f413ef9974de98835ef0bc48166aa","type":"text","conversion_output":true,"text":"Committee. Pediatrics. 2000;105(2):454-461.","text_display":" Committee. Pediatrics. 2000;105(2):454-461.","confidence":1,"confidence_rate":1},{"cnt":[[187,863],[1873,863],[1873,916],[187,916]],"region":{"top_left_x":187,"top_left_y":863,"width":1687,"height":54},"line":10,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"bb30149ba8cf4eb1b892341a9fffbcc7","type":"text","conversion_output":true,"text":"4. Carbajal R, Rousset A, Danan C, et al. Epidemiology and treatment of painful procedures in","text_display":"\n4. Carbajal R, Rousset A, Danan C, et al. Epidemiology and treatment of painful procedures in","confidence":0.9956097602844238,"confidence_rate":0.9999551040168622},{"cnt":[[315,927],[1320,927],[1320,980],[315,980]],"region":{"top_left_x":315,"top_left_y":927,"width":1006,"height":53},"line":11,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"ffcd3df316ae4866a4a93bb292769c03","type":"text","conversion_output":true,"text":"neonates in intensive care units. Jama. 2008;300(1):60-70.","text_display":" neonates in intensive care units. Jama. 2008;300(1):60-70.","confidence":1,"confidence_rate":1},{"cnt":[[190,996],[1720,996],[1720,1044],[190,1044]],"region":{"top_left_x":189,"top_left_y":995,"width":1532,"height":49},"line":12,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"96e5efbd191140f79d2471b3331d4994","type":"text","conversion_output":true,"text":"5. Anand KJ. Effects of perinatal pain and stress. Prog Brain Res. 2000;122:117-129.","text_display":"\n5. Anand KJ. Effects of perinatal pain and stress. Prog Brain Res. 2000;122:117-129.","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[190,1062],[1722,1062],[1722,1110],[190,1110]],"region":{"top_left_x":189,"top_left_y":1062,"width":1534,"height":49},"line":13,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"c0b4c77481ac4e72a6b3cdd831e54674","type":"text","conversion_output":true,"text":"6. Buskila D, Neumann L, Zmora E, Feldman M, Bolotin A, Press J. Pain sensitivity in","text_display":"\n6. Buskila D, Neumann L, Zmora E, Feldman M, Bolotin A, Press J. Pain sensitivity in","confidence":1,"confidence_rate":1},{"cnt":[[315,1128],[1743,1128],[1743,1176],[315,1176]],"region":{"top_left_x":315,"top_left_y":1128,"width":1428,"height":49},"line":14,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"4846c5ec14014203b6fcedde9b846e14","type":"text","conversion_output":true,"text":"prematurely born adolescents. Arch Pediatr Adolesc Med. 2003;157(11):1079-1082.","text_display":" prematurely born adolescents. Arch Pediatr Adolesc Med. 2003;157(11):1079-1082.","confidence":1,"confidence_rate":1},{"cnt":[[190,1192],[1859,1192],[1859,1245],[190,1245]],"region":{"top_left_x":189,"top_left_y":1192,"width":1671,"height":53},"line":15,"column":0,"font_size":30,"is_printed":true,"is_handwritten":false,"id":"7a5bf579dd764127ab81eeac3be72fea","type":"text","conversion_output":true,"text":"7. Grunau RE, Whitfield MF, Petrie J. Children's judgements about pain at age \\(8-10\\) years: do","text_display":"\n7. Grunau RE, Whitfield MF, Petrie J. 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