{"pages":[{"image_id":"bbffe277-e94d-471a-8395-80abee113530-1","page":1,"lines":[{"cnt":[[236,245],[1833,245],[1833,296],[236,296]],"region":{"top_left_x":236,"top_left_y":244,"width":1597,"height":53},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fcb0052aa81b44be854457a0e2adbbaa","type":"text","conversion_output":true,"text":"Title: Long-term treatment outcome on symptomatic osteoarthritis in patients with a meniscal tear:","text_display":"Title: Long-term treatment outcome on symptomatic osteoarthritis in patients with a meniscal tear:","confidence":1,"confidence_rate":1},{"cnt":[[236,296],[1313,296],[1313,350],[236,350]],"region":{"top_left_x":236,"top_left_y":296,"width":1077,"height":55},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7beb29dc93374f2f88b28fa899035de0","type":"text","conversion_output":true,"text":"Statistical analysis plan for the 5-year follow-up of the ESCAPE trial","text_display":" Statistical analysis plan for the 5-year follow-up of the ESCAPE trial","confidence":0.51513671875,"confidence_rate":0.9911946899548226},{"cnt":[[236,389],[468,389],[468,432],[236,432]],"region":{"top_left_x":236,"top_left_y":388,"width":233,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cc8887e225043ee8117dd41b467e478","type":"text","conversion_output":true,"text":"NCT01850719","text_display":"\n\nNCT01850719","confidence":1,"confidence_rate":1},{"cnt":[[236,473],[565,473],[565,522],[236,522]],"region":{"top_left_x":236,"top_left_y":472,"width":330,"height":51},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d1cc3232c1f4343b524329af26a14d5","type":"text","conversion_output":true,"text":"Date: May \\(15{ }^{\\text {th }} 2021\\)","text_display":"\nDate: May \\(15{ }^{\\text {th }} 2021\\)","confidence":0.9681507863247971,"confidence_rate":0.9990484696735403},{"cnt":[[236,653],[1798,653],[1798,703],[236,703]],"region":{"top_left_x":236,"top_left_y":653,"width":1563,"height":50},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57d1192925a84922bbb200e6f9b7baae","type":"text","conversion_output":true,"text":"This statistical analysis plan was developed and published online a priori of the 5 year data analyses.","text_display":"\n\nThis statistical analysis plan was developed and published online a priori of the 5 year data analyses.","confidence":1,"confidence_rate":1},{"cnt":[[236,705],[1869,705],[1869,758],[236,758]],"region":{"top_left_x":236,"top_left_y":704,"width":1634,"height":55},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08027db3a54c4899825e4d2260c374ba","type":"text","conversion_output":true,"text":"With this document we aim to provide insight and transparency for our statistical analyses and reporting","text_display":" With this document we aim to provide insight and transparency for our statistical analyses and reporting","confidence":1,"confidence_rate":1},{"cnt":[[236,761],[466,761],[466,810],[236,810]],"region":{"top_left_x":236,"top_left_y":760,"width":231,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e517a9e3f7714c94ad7abc9f4ab33af1","type":"text","conversion_output":true,"text":"of our results.","text_display":" of our results.","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"bbffe277-e94d-471a-8395-80abee113530-2","page":2,"lines":[{"cnt":[[236,331],[990,331],[990,389],[236,389]],"region":{"top_left_x":236,"top_left_y":330,"width":755,"height":59},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d5342e59eea46f8bcae38926a10a281","type":"section_header","conversion_output":false,"children_ids":["e4de95ef596146f3aa913dfef1bb6b98"],"text":"","text_display":""},{"cnt":[[241,337],[986,337],[986,382],[241,382]],"region":{"top_left_x":240,"top_left_y":337,"width":747,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4de95ef596146f3aa913dfef1bb6b98","type":"text","conversion_output":true,"parent_id":"2d5342e59eea46f8bcae38926a10a281","text":"Statistical analysis plan of the 5 year follow up","text_display":"\n\n\\section*{Statistical analysis plan of the 5 year follow up}","confidence":0.9487795829772949,"confidence_rate":0.9990779907548722},{"cnt":[[361,425],[1835,425],[1835,471],[361,471]],"region":{"top_left_x":360,"top_left_y":425,"width":1475,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d6ca7fce6214ca89f00dc71eae0e461","type":"text","conversion_output":true,"text":"We will analyze the 5 -year follow up data following the intention-to-treat principle. To test for","text_display":"\n\nWe will analyze the 5 -year follow up data following the intention-to-treat principle. To test for","confidence":0.974609375,"confidence_rate":0.9997574017969119},{"cnt":[[241,520],[1846,520],[1846,565],[241,565]],"region":{"top_left_x":240,"top_left_y":519,"width":1606,"height":47},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"820dc7bcf750404f8e3b79e8fb5f21f3","type":"text","conversion_output":true,"text":"robustness of the results, we will also perform an as-treated analysis. In the intention-to-treat analysis,","text_display":" robustness of the results, we will also perform an as-treated analysis. In the intention-to-treat analysis,","confidence":1,"confidence_rate":1},{"cnt":[[241,612],[1532,612],[1532,660],[241,660]],"region":{"top_left_x":240,"top_left_y":612,"width":1292,"height":48},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da59c173b1244890a43bf2fd1113dfc5","type":"text","conversion_output":true,"text":"participants will be analyzed in two groups, according to their allocated treatment.","text_display":" participants will be analyzed in two groups, according to their allocated treatment.","confidence":1,"confidence_rate":1},{"cnt":[[365,705],[1876,705],[1876,750],[365,750]],"region":{"top_left_x":365,"top_left_y":704,"width":1511,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cfd1ede05494f578b9d447305a776de","type":"text","conversion_output":true,"text":"For the as-treated analysis, participants will be divided into three groups: 1) patients allocated to","text_display":"\n\nFor the as-treated analysis, participants will be divided into three groups: 1) patients allocated to","confidence":0.9810137218009913,"confidence_rate":0.9998191783129493},{"cnt":[[241,799],[1798,799],[1798,846],[241,846]],"region":{"top_left_x":240,"top_left_y":799,"width":1559,"height":48},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6335d5001a81408882f9a8a2267ed01d","type":"text","conversion_output":true,"text":"partial meniscectomy who indeed underwent surgery; 2) patients allocated to physical therapy who","text_display":" partial meniscectomy who indeed underwent surgery; 2) patients allocated to physical therapy who","confidence":0.9775390625,"confidence_rate":0.9997751042405244},{"cnt":[[241,889],[1846,889],[1846,939],[241,939]],"region":{"top_left_x":240,"top_left_y":889,"width":1606,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58bff6aa7a7a4d218d9f894d44c7ecce","type":"text","conversion_output":true,"text":"indeed completed 16 (or more) physical therapy sessions; and 3) patients allocated to physical therapy","text_display":" indeed completed 16 (or more) physical therapy sessions; and 3) patients allocated to physical therapy","confidence":0.9072265625,"confidence_rate":0.9991152728131285},{"cnt":[[241,984],[1768,984],[1768,1033],[241,1033]],"region":{"top_left_x":240,"top_left_y":983,"width":1529,"height":51},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2a1f1637d73483c92273b5007087907","type":"text","conversion_output":true,"text":"who underwent surgery during the study period. Participants who did not undergo their allocated","text_display":" who underwent surgery during the study period. Participants who did not undergo their allocated","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[238,1079],[1869,1079],[1869,1124],[238,1124]],"region":{"top_left_x":238,"top_left_y":1078,"width":1632,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"beb86220b25d4fccbcb8450fd091d650","type":"text","conversion_output":true,"text":"treatment (either APM or completion of physical therapy) will be discarded from the as-treated analysis.","text_display":" treatment (either APM or completion of physical therapy) will be discarded from the as-treated analysis.","confidence":1,"confidence_rate":1},{"cnt":[[236,1171],[1068,1171],[1068,1218],[236,1218]],"region":{"top_left_x":236,"top_left_y":1170,"width":832,"height":49},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7a1b6e5f84f4e0b89d34b89898c1991","type":"text","conversion_output":true,"text":"Their 5 year outcomes will be reported descriptively.","text_display":" Their 5 year outcomes will be reported descriptively.","confidence":0.9990236759185791,"confidence_rate":0.999983986997124},{"cnt":[[361,1263],[1863,1263],[1863,1313],[361,1313]],"region":{"top_left_x":360,"top_left_y":1263,"width":1503,"height":50},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f02cbe8af4344190b648c56a14ca0e34","type":"text","conversion_output":true,"text":"We will analyze binary outcomes with generalized estimating equation (GEE) with exchangeable","text_display":"\n\nWe will analyze binary outcomes with generalized estimating equation (GEE) with exchangeable","confidence":1,"confidence_rate":1},{"cnt":[[241,1358],[1882,1358],[1882,1405],[241,1405]],"region":{"top_left_x":240,"top_left_y":1357,"width":1643,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d812424568914a1daaa914ed45073f5c","type":"text","conversion_output":true,"text":"structure. We will perform GEE analyses to evaluate symptomatic knee OA from baseline to 5 year follow","text_display":" structure. We will perform GEE analyses to evaluate symptomatic knee OA from baseline to 5 year follow","confidence":0.9814541339874268,"confidence_rate":0.9998298326902371},{"cnt":[[241,1450],[1824,1450],[1824,1497],[241,1497]],"region":{"top_left_x":240,"top_left_y":1450,"width":1585,"height":48},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a933360e3744b919883f5772cf2b5c2","type":"text","conversion_output":true,"text":"up. Interaction effects of treatment (APM vs physical therapy) and time (baseline, 2 years and 5 years","text_display":" up. Interaction effects of treatment (APM vs physical therapy) and time (baseline, 2 years and 5 years","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[236,1543],[1779,1543],[1779,1592],[236,1592]],"region":{"top_left_x":236,"top_left_y":1542,"width":1543,"height":50},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb7f3b73ade2418f9548a8d3b396fa3b","type":"text","conversion_output":true,"text":"follow-up) will be calculated to test between-group differences in changes over time. The adjusted","text_display":" follow-up) will be calculated to test between-group differences in changes over time. The adjusted","confidence":0.9985356330871582,"confidence_rate":0.9999857725269791},{"cnt":[[241,1637],[1762,1637],[1762,1687],[241,1687]],"region":{"top_left_x":240,"top_left_y":1637,"width":1522,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38bacd93a1ba4816ac96913a0e7de944","type":"text","conversion_output":true,"text":"between-group difference will be assessed by adding potential confounders to the models. These","text_display":" between-group difference will be assessed by adding potential confounders to the models. These","confidence":1,"confidence_rate":1},{"cnt":[[241,1732],[1837,1732],[1837,1779],[241,1779]],"region":{"top_left_x":240,"top_left_y":1731,"width":1597,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50fd92f56b084382ae24e2258744bfdf","type":"text","conversion_output":true,"text":"potential confounders are BMI, age, baseline KL score, baseline pain during activities and frequency of","text_display":" potential confounders are BMI, age, baseline KL score, baseline pain during activities and frequency of","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[241,1826],[329,1826],[329,1871],[241,1871]],"region":{"top_left_x":240,"top_left_y":1826,"width":89,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42722ee4032c44369cf709d404c437e2","type":"text","conversion_output":true,"text":"pain.","text_display":" pain.","confidence":1,"confidence_rate":1},{"cnt":[[363,1916],[1850,1916],[1850,1966],[363,1966]],"region":{"top_left_x":363,"top_left_y":1916,"width":1487,"height":50},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f61b225aaa44e2c8cd9c968a40012cc","type":"text","conversion_output":true,"text":"Continuous outcome measures will be analyzed using linear mixed model analysis with random","text_display":"\n\nContinuous outcome measures will be analyzed using linear mixed model analysis with random","confidence":1,"confidence_rate":1},{"cnt":[[241,2011],[1820,2011],[1820,2058],[241,2058]],"region":{"top_left_x":240,"top_left_y":2010,"width":1580,"height":49},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea5a60c52e024a949beff730ff89918e","type":"text","conversion_output":true,"text":"intercept. We will define the overall crude intervention effects by a model with only treatment group","text_display":" intercept. We will define the overall crude intervention effects by a model with only treatment group","confidence":1,"confidence_rate":1},{"cnt":[[241,2103],[1734,2103],[1734,2151],[241,2151]],"region":{"top_left_x":240,"top_left_y":2103,"width":1494,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb1aff601bf34f5dac767ff9e823e90d","type":"text","conversion_output":true,"text":"and the baseline value of the outcome as independent variables. We will add time and time-by-","text_display":" and the baseline value of the outcome as independent variables. We will add time and time-by","confidence":1,"confidence_rate":1},{"cnt":[[236,2196],[1878,2196],[1878,2245],[236,2245]],"region":{"top_left_x":236,"top_left_y":2195,"width":1642,"height":51},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c645bd61e21345bc926e7250d1fa2b9c","type":"text","conversion_output":true,"text":"treatment interaction terms to specify crude intervention effects for each follow-up time point. Adjusted","text_display":"treatment interaction terms to specify crude intervention effects for each follow-up time point. Adjusted","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[241,2290],[1772,2290],[1772,2340],[241,2340]],"region":{"top_left_x":240,"top_left_y":2290,"width":1533,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6163826fa0de49bcad604eeacf7acc4c","type":"text","conversion_output":true,"text":"intervention effects will be calculated using similar models, expanded with the following potential","text_display":" intervention effects will be calculated using similar models, expanded with the following potential","confidence":1,"confidence_rate":1},{"cnt":[[241,2385],[1721,2385],[1721,2432],[241,2432]],"region":{"top_left_x":240,"top_left_y":2384,"width":1481,"height":49},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d7479b1167e4808b5c6aedaf09c51a0","type":"text","conversion_output":true,"text":"confounders as independent variables: level of OA at baseline using the Kellgren and Lawrence","text_display":" confounders as independent variables: level of OA at baseline using the Kellgren and Lawrence","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"bbffe277-e94d-471a-8395-80abee113530-3","page":3,"lines":[{"cnt":[[236,245],[1837,245],[1837,299],[236,299]],"region":{"top_left_x":236,"top_left_y":244,"width":1601,"height":55},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"651782749fe44bf0b167281fa29b59b7","type":"text","conversion_output":true,"text":"classification[7], baseline pain during weight bearing, BMI at baseline (three categories: \\(<25,25-30\\), or","text_display":"\nclassification[7], baseline pain during weight bearing, BMI at baseline (three categories: \\(<25,25-30\\), or","confidence":0.968040581792593,"confidence_rate":0.9997270854055713},{"cnt":[[236,335],[1858,335],[1858,391],[236,391]],"region":{"top_left_x":236,"top_left_y":335,"width":1623,"height":57},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68af1a3ce5374591b96940ed3f643b7c","type":"text","conversion_output":true,"text":"\\(30-35 kg / m 2)\\) and gender. In all models, physical therapy will be defined as the reference treatment. All","text_display":" \\(30-35 kg / m 2)\\) and gender. In all models, physical therapy will be defined as the reference treatment. All","confidence":0.993659496307373,"confidence_rate":0.999943712291653},{"cnt":[[236,430],[1863,430],[1863,483],[236,483]],"region":{"top_left_x":236,"top_left_y":429,"width":1627,"height":55},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90edc912818745ab856dec1f4e2a63d3","type":"text","conversion_output":true,"text":"analyses will be performed using IBM SPSS version 27 (IBM, Armonk, NY), and statistical significance will","text_display":" analyses will be performed using IBM SPSS version 27 (IBM, Armonk, NY), and statistical significance will","confidence":1,"confidence_rate":1},{"cnt":[[236,524],[703,524],[703,574],[236,574]],"region":{"top_left_x":236,"top_left_y":524,"width":467,"height":50},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fec2307786e04862b48951a642b30d69","type":"text","conversion_output":true,"text":"be assessed at the 0.05 level.","text_display":" be assessed at the 0.05 level.","confidence":0.99951171875,"confidence_rate":0.9999871474379078}],"page_height":2750,"page_width":2125,"languages_detected":[]}]}